Nova Patents
SI2145002T1

Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells

Abstract

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Term

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32 claims: 1 independent, 31 dependent

  1. 1
    Bacterial - derived, intact minicelice that encompass the functional nucleic acids are free of the plasmid for the in vivo delivery into mammalian cells PATENT APPLICATIONS 1. A composition comprising (a) a plurality of intact, bakterijsko- obtained minicelic, wherein each of said plurality minicelica encompasses regulatory RNA that is packaged into said minicelici, and (b) a pharmaceutically acceptable carrier therefor, wherein the absence of said minicelic construct for in situ expression of these regulatory RNA, where the mentioned reguiatorna RNA selected from the group consisting of siRNA, miRNA and shRNA, and wherein said plurality comprises a therapeutically effective amount of said regulatory RNA.
  2. 32
    The method according to any one of claims 28 to 31, wherein the incubation is carried out in a buffer in saline solution.
Independent claims2