Nova Patents
PL383331A1

Peg-urate oxidase conjugates and use thereof

Abstract

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75 % of the uricolytic activity of the unmodified enzyme.

Term

Term ended

Projected expiry passed 2 August 2019, 7.1 years ago.

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188 members in 28 offices

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Priority claims
DocumentOfficeKindDate
13039298United States of AmericaA
13039298United States of AmericaA
US19980130392–––

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CA2338665A1CanadaA1
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WO0007629A2World Intellectual Property Organization (WIPO)A2
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BR9912974ABrazilA
EP1100542A2European Patent Office (EPO)A2
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KR20010072287ARepublic of KoreaA
CA2398679A1CanadaA1
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AU4997501AAustraliaA
CN1322141AChinaA
HU0103003A2HungaryA2
HUP0103003A2HungaryA2
PL346224A1PolandA1
PL383331A1This recordPolandA1
HK1037330A1Hong Kong, ChinaA1
WO0159078A3World Intellectual Property Organization (WIPO)A3
IL141220D0IsraelD0
ZA200101814BSouth AfricaB
JP2002522399AJapanA
BR0108386ABrazilA
EP1254237A2European Patent Office (EPO)A2
KR20020087934ARepublic of KoreaA
MXPA02007545AMexicoA
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IL151065D0IsraelD0
ZA200207206BSouth AfricaB
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AT298251TAustriaT
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DE69925917D1GermanyD1
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IL151065AIsraelA
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PL202799B1PolandB1
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JP2009254376AJapanA
EP2158923A1European Patent Office (EPO)A1
TWI322184BTaiwan Province of ChinaB
EP1254237B1European Patent Office (EPO)B1
AT463576TAustriaT
ATE463576T1AustriaT1
DE60141742D1GermanyD1
US7723089B2United States of AmericaB2
PT1254237EPortugalE
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