Nova Patents
PL323256A1

Angiostatin fragments and angiostatin aggregate and method of using them

Abstract

Fragments and an aggregate form of an endothelial cell proliferation inhibitor and methods of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to krinkle structures occurring within the endothial cell proliferation inhibitor. Angiostatin is also prepared in an aggregate form. The endothelial cell inhibiting activity of the angiostatin fragments and the aggregate angiostatin provide a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.

Term

Term ended

Projected expiry passed 26 April 2016, 10.4 years ago.

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113 members in 24 offices

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DocumentOfficeKindDate
42974395United States of AmericaA
42974395United States of AmericaA
60559896United States of AmericaA
60559896United States of AmericaA
61278896United States of AmericaA
61278896United States of AmericaA
429743–––
605598–––
612788–––
US19950429743–––
US19960605598–––
US19960612788–––

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