Nova Patents
CA2219081A1

Angiostatin fragments and aggregate angiostatin and methods of use

Abstract

Fragments and an aggregate form of an endothelial cell proliferation inhibitor and methods of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to krinkle structures occurring within the endothial cell proliferation inhibitor. Angiostatin is also prepared in an aggregate form. The endothelial cell inhibiting activity of the angiostatin fragments and the aggregate angiostatin provide a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated diases.

Term

Term ended

Projected expiry passed 26 April 2016, 10.4 years ago.

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113 members in 24 offices

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Priority claims
DocumentOfficeKindDate
42974395United States of AmericaA
42974395United States of AmericaA
60559896United States of AmericaA
60559896United States of AmericaA
61278896United States of AmericaA
61278896United States of AmericaA
9605856United States of AmericaW
9605856United States of AmericaW
08429743–––
08605598–––
08612788–––
PCTUS9605856–––
US19950429743–––
US19960605598–––
US19960612788–––
WO1996US05856–––

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NO964598D0NorwayD0
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WO9635774A2World Intellectual Property Organization (WIPO)A2
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EP0758390A1European Patent Office (EPO)A1
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CZ312296A3CzechiaA3
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CN1636594AChinaA
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EP0758390B1European Patent Office (EPO)B1
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DE69535405D1GermanyD1
EP1783215A1European Patent Office (EPO)A1
EP0824546B1European Patent Office (EPO)B1
AT368051TAustriaT
DE69637179D1GermanyD1
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