Method of steroid derivatives preparation

The invention has relation to the steroid derivatives, especially, to the compound of general formula (I)in which R1 represents-N-(C1-C4)-alkyl dihydraindolyl, pyridinyl, phenyl, substituted by di(C1-C4)-alkylaminogroup or by di-(C1-C4)-alkyl group (in which nitrogen may be oxydired), by pyrollidin, di-(C1-C4)-alkylamino-(C1-C4)-alkylaky-or trimetil sylyl group;R2 - CH3, C2H5; R3-OH, CH3O, ethinyl, carbonyl, -C-NOH;R4-H, (C2-C4)-alkenyl, (C3-C6)-alkaden (C2-C6)-alkinyl (may be substituted by halogen, C6H5,(CH3)3 SI, lowert alkenyl); B and C form double bond or epoxy group, which have pharmocological valuable properties.The purpose of invention is creation of new substances with indis tinctive activity for given class.Synthesis is lead from corresponding ketal (A-ketal group, which may be cyclic or noncyclic), which is degradated by cationexchanged sulforesin or Hcl. The obtaining product incase of necesity is treated by hydroxylamine or if R1-di (C1-C4)-alkyl-amino-(C1-C4)-alkylphenyl, is oxydized for example metafluorineoxobenzoic acid with obtaining of substance of special destination, containing group, oxydired in nitrogen position and 9,10-epoxygroup.The new substances manifest the pronounced affinity as regards glucokorticosteroid and progestogenic receptor in the absence of the activity on the mineralkortikoid and estrogenic receptor having toxicity 100mg/kg of DL50.