Injection device with an improved metering member and a pre-tensioned ejection spring

0001The invention relates to an injection device for administering a fluid product, in particular a medicament, such. As insulin for diabetes therapy. In particular, the invention relates to a drive and metering device for such an injection device.

0002The term "drug" here includes any flowable medical formulation which is suitable for the controlled administration by an agent such. As a cannula or hollow needle, through, for example, comprising a liquid, a solution, gel or fine suspension which (s) containing one or more active pharmaceutical ingredients. Medicament may be a composition comprising a single active ingredient or a pre-mixed or co-formulated composition by more active compounds from a single container. Medication includes drugs such as peptides (eg, insulin, insulin-containing medications, GLP-1 containing and derived or analogous preparations), proteins and hormones, biologically derived or active agents, active substances based on hormones or genes Nährformulierungen, enzymes and other substances in both solid (suspended) or liquid form but also polysaccharides, vaccines, DNA or RNA or Oglionukleotide, antibodies or parts of antibodies and suitable basic materials and excipients.

0003The invention is a development of the invention from the <patcit id="pcit0001" dnum="WO2013144021A1"><text>WO 2013/144021 A1</text></patcit>,

0004It is an object of the invention to provide a drive and metering device for an injection device for administration of a liquid product, the simple use of the device, in particular a single dose setting allows the user and yet allows a compact design.

0005The object is solved by the features of claim 1. Advantageous developments emerge from the dependent claims, the description and the figures.

0006The invention relates to a drive mechanism for an injection device for administering a liquid medicament or product. The drive mechanism comprises a housing. The housing is preferably sleeve-shaped and / or elongated. The housing may be, for. Example, extending along its longitudinal axis.

0007The housing can optionally house product containers or make the product container itself. The housing may be one or more parts. For example, the housing may form a proximal housing part which comprises the drive and metering device or has. The housing may further comprise a product container holder of the product container, such. As a carpule, receives and is connected to the housing or the proximal housing part. This compound may be such that the product container holder and the housing or the proximal housing portion after bonding insoluble, ie, can only be released by destruction of connecting elements. Such a solution is particularly important in disposable injection devices an advantage that the product contained in the product container is distributed in full after, be disposed of as a whole. Alternatively, the product container holder can also be releasably attached to the housing, whereby it is possible, although less preferred, where appropriate, to use the drive and metering several times, that is to exchange an empty product container to a filled product container.

0008The housing is preferably adapted to be gripped by the user of the device. In particular, the housing may have a substantially cylindrical shape. The housing can, for. Example, comprise a pointing device, in particular a window by means of, or through which a currently set dose, preferably, can be read from a scale of a dose Activate setting element.

0009In a first aspect, the, for example, the invention further advantageously forms, comprising the drive and metering device that forms an injection device in particular together with the product container next to a housing, a dose display element, over its periphery a dosage scale is disposed. The dose indicator element may be annular, for. Example, in cross-section. The dose indicator may be a dose indicator barrel or a dose indicator ring z. B.. The dose scale may extend over the circumference of the dose indicator element, preferably helically, extend. The dose scale preferably comprises a plurality of values, which are disposed lined up and result in the dose scale. Preferably, numerical values ​​indicating the desired product dose in International Units (IU) or in milligrams.

0010Alternatively, the dose can scale without pitch over the circumference of the dose display element, such as. For example, the dose indicator ring, can be arranged, whereby then repeat the scale values ​​according to a rotation of the dosage indicator member. At a dose scale with slope, ie a helical dose scale, the dose indicator, in particular, the dose indicator barrel can be rotated more than one revolution, without a repeat of the scale values, whereby the scale values ​​can be displayed advantageously greater or more scale values.

0011The drive and metering device further comprises a pointing device, whereby the dose indicator element for setting the dose to be administered, is rotatable relative to the pointing device and in particular about a pivot axis, which preferably corresponds to the longitudinal axis of the drive and metering device and / or of the dose display element. This may be a pure rotational movement, ie a rotational movement without axial movement superimposed act. Preferably, the rotational movement is superimposed on an axial movement, whereby the dose indicator element for setting the dose to be administered can be screwed relative to the pointing device. A screwable dose indicator can be advantageously combined with a helical dose scale, the screwing and the dose scale advantageously have the same slope. A rotatable without axial movement of the dose indicator can be advantageously combined with a gradient free dose scale.

0012By the pointing device which is preferably formed on the housing, a value of the dose scale is read corresponding to the set dose. The pointing device may, for. Example, a window that can be formed by an opening in the housing or by a transparent insert. Alternatively or optionally, the pointing device can be an arrow or may have an arrow z. B. in addition to the window marks the value of the dose scale corresponding to the set dose. This is z. B. advantageous if there is another value at least partially appear in the window to make sure a clear dose selection. The pointer can, for. Example, a projection or a print or a notch or the like.

0013The drive and metering device comprises a metering member, which is for example designed as a control button and can be optionally referred to as the dosage setting member. The dosing member is preferably of the user (patient, physician, medical auxiliaries) of the drive and metering tangible and preferably forms an outer, especially externally accessible surface of the drive and metering. For setting the distributable or dose to be administered the dosing member is preferably grasped by the user and relative to the housing and in particular of the pointing device about a pivot axis, which preferably corresponds to the longitudinal axis of the elongated example designed drive and metering twisted. The dosing member is preferably connected axially fixed to the housing, immovable in particular along a longitudinal axis of the housing, whereby advantageously the intuitive handling of the device is facilitated by the user, since he only needs a rotational movement of the dosing run for dose adjustment.

0014In particular, the dose indicator, at least during dose titration rotationally but be axially slidably connected or coupled to the dosing example. For intuitive operation, it is advantageous if the dose indicator is also rotated with rotation of the dosing member to a rotation angle to this rotational angle.

0015The drive and metering device may comprise an actuator for example in the form of an actuating knob. The actuator may form an outer surface of the drive and metering device and / or be accessible from outside. The actuator may be formed or forming this end at the proximal, especially the rear end of the drive and metering. The actuator can be operated in this way advantageously with the thumb of the hand which grasps the housing, press in particular. By releasing the actuator, the actuator can be stopped. Under "press" is the displacement of the actuator understood in the drive and metering, particularly in the distal direction, whereby in particular a product delivery can be effected. The actuator is advantageously displaceable relative to the dosing member and may be axially slidably received in particular of the dosing member.

0016The actuator may advantageously against the force of a spring, in particular a reset or clutch spring displaced, in particular, be operable, which this spring is tensioned. By releasing this spring can reset the actuator, particularly relative to the dosing member, particularly in the proximal direction or from the drive and metering out move.

0017The drive and metering device further comprises a bearing element, by which the dose indicator element is in an engaged. This engagement advantageously causes the rotational or screwing movement of the dosage indicator member relative to the pointing device. For example, the engagement between dose indicator element and the bearing element can be a threaded engagement. In particular, the bearing element has an external thread and the dose indicator element may have an internal thread, and these threads engage with each other and thereby cause the dose display element is screwed relatively to the bearing member.

0018In particular, the dose display element between a maximum dose position and a zero dose position is reciprocally rotatable or screwable. In the zero dose position is advantageous, the dose or number "0" on the pointing device to be read. In the maximum dose position can be read advantageously the maximum distributable with the drive and metering product dosage.

0019In the zero dose position can be locked against rotation in one direction of rotation the dose indicator, namely, the direction of rotation, which would cause a dose is set less than zero. In the zero dose position, the dose indicator member may preferably be moved in the direction of rotation which causes an increase of the dose. In the maximum dose position the dose indicator is preferably against the rotation in one direction of rotation, namely, in the direction of rotation, which would cause the measurement of the dose over the maximum settable dose addition, blocked. The dose indicator member can be rotated in the maximum dose position, in particular only in the direction of rotation that causes a reduction of the product dose.

0020The dose indicator element may. For example, comprise a stop which abuts in the zero dose position to a counter-stop, thus preventing the rotation in one direction of rotation. The same or an additional attachment of the dose indicator element can prevent rotation of the dosage indicator member over the maximum dose addition. In particular, this may be another counter-attack, namely a maximum dose counter stop be provided. Accordingly, the other counter-stop can be called a zero dose counter stop. The dose indicator can therefore have a zero dose stop for the zero dose counter stop and a maximum dosage stop for the maximum dose counter stop. Preferably, the stop or stops circumferentially and / or axially acting.

0021The drive and metering device according to the first aspect may be preferably such that the bearing element is displaceable relative to the housing and along the rotational axis, in particular in the distal direction together with the dose display element. This aspect may further training aspect described advantageously the drive and metering for a second herein. Alternatively, the dosage indicator member may have a thread which is in engagement with the housing. Thus, the dose indicator can indeed screw relative to the housing back and forth, but do not move independently of the screw movement with a particularly pure axial movement.

0022Preferably, the actuator is coupled to the bearing element, that a displacement of the actuator relative to the housing and / or the dosing member causes a displacement of the bearing element relative to the housing and / or the dosing member, in particular along the longitudinal axis of the drive and metering device.

0023The fact that the dose display element according to the invention in engagement with the bearing element and the bearing element can be moved relative to the housing and along the rotational axis, also the dose indicator can be relative to the housing and along the axis of rotation independent of the rotational or screwing movement, which the dose display element performs during dose setting, move. The drive and metering device according to the second aspect can basically also be advantageously combined with the alternate dose indicator element in the threaded engagement with the housing or a housing-fixed member. In this alternative, the bearing element may be formed by the housing or may be part of the housing, wherein the bearing element then rotating z. B. and axially fixed with respect to the rest of the housing may be.

0024Advantageously can be read on the pointing device and / or the dose indicator that the bearing element has been moved together with the dose indicator. This can be controlled by the user, in the operating state of the drive and metering is, ie whether the drive and metering in particular operates the actuator for a distribution or is unconfirmed.

0025In a preferred variant may be slidable relative to the pointing device, the housing and along the rotation axis together with the dose display element, the actuator and / or the bearing element. In the pointing device, especially in the windows of the pointing device may appear different from the dose scale marks when the bearing element is moved. The marking is preferably arranged on the dose indicator. If the bearing element is not displaced, particularly the drive and metering of the product distribution is unconfirmed, the marking may be located outside of the pointing device, be obscured such. B. by a housing or another element. If the bearing element displaced, particularly the drive and metering of the product release is pressed, the marker can emerge from the covered area, so that they appear in particular at or pointing device or can be read. If the actuation of the drive and metering device is interrupted or finished, the bearing member can return to the original position, whereby the label is preferably removed from the range of the pointing device and in particular concealed.

0026In an alternative variant may be displaceable relative to the housing and along the rotational axis of the actuating member and / or the bearing element together with the dose display element and the pointing device. The pointing device may, for. Example, be a diaphragm or at least fulfill the function of a diaphragm. For example, the pointing device can be fixed at least axially, preferably be rotatably connected to the bearing element. Basically, the bearing element can make the pointing device. Of course, it is also possible that the pointing device is a separate part from the bearing element. The pointing device may be a sleeve-like z. B..

0027In this variation can effect the displacement of the bearing element, that in the area of ​​the pointing device different from the dose scale mark appears, which is arranged or formed at or on the pointing device. For example, may be disposed within the housing, the pointing device. The marking of the pointing device may be hidden in de-energized condition of the drive and metering of the housing or another element. If the drive and metering, in particular, the actuator is actuated, so that the dose indicator moves with the pointing device, the label may emerge from its cover, so that the marking is erblickbar or read. If the operation is interrupted or stopped, the dose display element can be moved back together with the pointing device and the bearing element in its initial position so that the label is again arranged under the cover.

0028Generally preferred a spring, in particular a clutch or restoring spring can be tensioned in the operation of the drive and metering for a product delivery. In other words, the bearing element can be displaced in the operation against the force of a particular such a spring, in particular from an unactuated position to an actuated position. The spring may be a helical or spiral spring, for. Example, which acts as a compression spring. This spring also causes the pause or stop the operation of the bearing element is in its initial position or unconfirmed position reset. In particular, the storage element is displaced in the operation in the distal direction. By means of the spring is the bearing element displaced in the proximal direction back when the operation is interrupted or terminated.

0029The operation of the actuator causes in particular, that the bearing element is displaced along with the dosage indicator member relative to the housing and along the axis of rotation. In a broader sense the actuation of the actuator may cause a propulsion member whose distal end is intended to act on a piston of the fastened or fastenable to the drive and metering product container in the distal direction, in particular the dispensing direction is moved. The actuator may, for. Example, at the proximal, ie the rear end of the drive and metering can be arranged or form the proximal end of the drive and metering. Alternatively it can be arranged laterally on the housing and / or between the distal end and the proximal end of the drive and metering device, the actuating element. In general it can be formed in the manner of an actuating knob the actuator. The actuating member is preferably moved relative to the housing or the dosing member during actuation. Specifically, the user of the device, the actuator advantageously for example with the thumb of his hand, which surrounds the housing of the drive and metering press.

0030The actuator is preferably connected to the bearing element such that it moves the bearing element upon actuation, in particular via a coupling member which z. B. axially fixed and can be rotatably connected to the bearing element.

0031In general preferred embodiments may cause the operation of the actuator, that the dose display element relative to or rotated on the bearing element or the housing, in particular screwed, in particular in a direction that is at the rotational movement of the pointing device moving past values ​​of the dose scale count back. Preferably are the angle of rotation of the dosage indicator member and the delivery stroke of the driving member in a proportional relation, in particular at any time during the dose distribution. This can be realized, the back one in the dose distribution, until it finally reached the value 0, the distribution of this dose is then finished with a real-time display. If the actuation of the release during the turning back of the dose display element is interrupted, the dose indicator displays the required yet for the release of these dose remaining amount.

0032In a variant, the drive and metering device be configured such that is required for the turning back of the dose display element and / or the displacement of the driving member in the distal direction energy manually applied in particular by a force acting on the actuator force of the user. For example, the dosage setting member, in particular the dosing of the proximal end of the housing for a dose adjustment may be unscrewed, while being scaled back to the dose distribution under operation of the actuator in the housing.

0033In a preferred alternative variant, the drive and metering device be configured such that the energy required for the turning back of the dose display element and / or the displacement of the driving member in the distal direction automatically, in particular by a spring contained in the drive and metering device, in particular dispensing spring in which the required energy is stored or can be, provided. For example, can be dispensed stored in the dispensing spring spring energy upon operation of the actuator to the dose display element and / or the propulsion member, so that the dose display element is turned back and the propulsion member are shifted in the distal direction. The dispensing spring may be coupled with the dosing z. B. that a rotation of the dosing member biases the dispensing spring during dose setting. The spring can then save the required for the dose of energy.

0034In a preferred alternative, the spring may be biased at delivery of the drive and metering already with so much energy that the energy is sufficient for multiple distributions of product dosage, in particular for the distribution of the total is sufficient from the product container distributable product. In this alternative, the dosing be decoupled at the dose setting by the spring, that is not to be so coupled to the dispensing spring, that a rotation of the dosing member causes a tensioning of the spring. This can be turned with much less effort, the dosing for the user in the dose setting.

0035The dosing member, particularly the dosing button, the actuator, in particular surrounding or take actuator button. Thus, the dosing member and the actuating member may form the proximal end of the drive and metering device. Preferably, the actuating member for actuating is displaceable relative to the dosing member.

0036In embodiments in which the energy required for the dividend will be provided automatically, the dosing may be preferably relatively, in particular on the housing but axially be rotatable.

0037In a second aspect, of the particular starting the present invention and which can be combined with features of the first aspect, in particular with or without the feature that the bearing element is displaceable relative to the housing and along the rotation axis together with the dose display element, the drive can be - and metering have a propulsion member whose distal end is provided on a piston, particularly indirectly or preferably to act immediately. The piston may be part of an attached or fastened to the drive and dosing product container, such. As a carpule. The propulsion member may be referred to in a broader sense as a piston rod, wherein the propulsion member may not necessarily be solid, but hollow, such. As can be configured sleeve-shaped. At the distal end of the driving member, an optional z. B. rotatable flange be formed, which presses against the piston. Generally, it is preferred that the distal end of the tunneling member pushes against the piston. The propulsion member is preferably displaceable relative to the housing along the longitudinal axis of the drive and metering device.

0038The drive and metering, an abutment, preferably a guide, said the propulsion member is movable relative to the abutment and preferably also relative to the guide in one direction, particularly in the distal direction or in the dispensing to a distribution of the set product dose cause. Preferably, the propulsion member may by or on the guide, to be guided along the longitudinal axis of the drive and metering straight or axially. In particular, the propulsion member may be rotationally fixed relative to the abutment and / or the management and / or the housing. In an alternative embodiment, the propulsion member may be relatively combined with the abutment or the housing with a longitudinal movement rotatable, that is, to the abutment to be screwed relatively, although less preferred. In general, the guide and / or the abutment sleeve-shaped of the housing, in particular a sleeve-shaped housing part or for example, fixed to the housing element are formed.

0039The propulsion member and the guide, in particular formed by the housing, for example, in a direct or via an intermediate member in an indirect be engaged, which prevents rotation of the driving member relative to the abutment or the housing, but an axial movement or a screw movement of the driving member relative to the abutment or the housing permits. The guide may be an axial guide or a thread with a non-self-locking thread pitch z. B..

0040The guide or the abutment and / or the guide housing forming section, in particular an inner sleeve may preferably surround the spurring member, its sleeve-shaped surround and / or fixed to the housing such. B. or be formed by the housing. An annular gap may be formed between this sleeve-shaped housing portion and an outer, also preferably sleeve-shaped housing part, which has the advantage that an existing optional dose display element, in particular dose indicator barrel may be received therein. This causes the length of the drive and metering device can be kept low.

0041In the second aspect, the drive and metering example, at least one such exhibit one, two or three, acting between the driving member or a rotational member and the abutment and especially arranged dispensing spring. Exactly. The at least one spring can be supported z. B. to the propulsion member and / or the abutment. For example, the z. B. can be supported only dispensing spring with its distal end to the driving element and with its proximal end to the abutment. In particular, the at least one dispensing spring may be disposed within the guide or the guide forming sleeve-shaped housing part. Is the advancing sleeve-shaped member, the at least one dispensing spring may be arranged inside the propulsion member. Alternatively, a first dispensing spring and a second dispensing spring may be arranged in particular between the kinematic propulsion member and the guide or the guide forming sleeve-shaped housing part. The first dispensing spring may, for. Example, surrounding the second dispensing spring, or vice versa. In particular, the second dispensing spring may be arranged concentrically with the first dispensing spring. The first dispensing spring and the second dispensing spring may be connected in parallel or in series z. B.. Parallel Ausschüttfedern entail that the first and second dispensing spring can support each with its distal end to the driving member and each having its proximal end to the abutment. This can add up to a total spring constant, the spring constants of the first and second dispensing spring. Connected in series Ausschüttfedern in particular means that the distal end of one of first and second dispensing spring pushes against the proximal end of the other of first and second dispensing spring, in particular directly or preferably indirectly, such as. For example, via the intermediate member. For example, is based on the first dispensing spring on the abutment and the intermediate member and the second dispensing spring on the intermediate member and the driving member. For example, may be located distal to the proximal end of the second dispensing spring, the distal end of the first dispensing spring. Because of the link, the spring force of the first spring of the distal end can be transmitted to the proximal end of the second dispensing spring. In particular, the intermediate member may be sleeve-shaped and be disposed in an annular gap between the first and second dispensing spring. Series-connected Ausschüttfedern allow for a relatively long travel a relatively constant spring force.

0042For example, can be a helical or coil spring, the at least one dispensing spring, in particular the first and second dispensing spring which acts as a compression spring or as a torsion spring. The at least one dispensing spring is biased and acts on the driving member, which she tries to the abutment in the distal direction to shift the propulsion member relative ie in the dispensing direction. The at least one dispensing spring is particularly biased in the delivery state of the drive and metering device with so much energy that they can distribute that particular in several distributions of individual product doses, the maximum from the product container or a total distributable amount of product in several individual distributions. The drive and metering device is designed so that after each individual dividend or distribution of the product dose, the next dose is distributable readjusted. Unlike embodiments in which a dispensing spring is newly biased at each dose setting, a simpler dosage adjustment may be achieved by the pre-tensioned with the energy required for the distribution of the maximum distributable from the product container product Volume spring, as the relative to dose to the housing rotatable dosing member is rotatably easier then because the spring does not need to be biased at the dose setting. This increases the ease of use for the user of the device.

0043The drive and metering device may further comprise a rotary member whose rotation causes the drive spring releases energy to the driving member, whereby the driving member is moved in the distal direction. The rotary member preferably takes over the function of a control member, wherein rotation of the rotation member about a certain angle of rotation causes the advance of the driving member about a particular delivery stroke. By selectively enabling or disabling rotation of the rotary member relative to the housing of the drive spring can be accepted that it can move the driving member relative to the abutment in the distal direction or can not move. In particular, the rotary member may be coupled with the actuator that it is released on actuation of the actuator for a product delivery for rotation relative to the housing and is locked in case of non operation of the actuator for rotation relative to the housing. In particular, can be disposed between actuator and rotary member at least one coupling, which causes the enabling and disabling the rotation of the rotation member relative to the housing.

0044Advantageously, the at least one clutch by actuating the Betätigungsg song the rotation of the rotation member relative to the housing to release and block by releasing the actuating member, the rotation of the rotary member relative to the housing.

0045According to a first sub-aspect, the at least one spring comprise a first helical compression spring and a second helical compression spring being supported, the first compression spring to the abutment and an intermediate member and the second compression spring on the intermediate member and the propulsion member. The intermediate member, the driving member rotatably coupled to the housing. The first compression spring can be supported at its distal end, for example, on the intermediate member, and its proximal end, for example on the abutment. The second compression spring may be supported with its distal end, for example, on the driving member and with its proximal end, for example, on the intermediate member. Specifically, the first compression spring and the second compression spring are connected in series. Under a pressure spring is meant acting as a compression spring helical spring. The intermediate member may be annular, for example, and surrounded the propulsion member. In particular, the intermediate member may be disposed in an annular gap between an inner sleeve of the housing which forms the guide, and the driving member.

0046In particular, the intermediate member with the housing, in particular the inner sleeve and / or the guide in such a procedure may be that the intermediate member is displaceable relative to the housing along the longitudinal axis and rotationally about the longitudinal axis. The intermediate member may be connected to the driving member in such an engagement that the intermediate member is displaceable relative to the driving member along the longitudinal axis and rotationally about the longitudinal axis. In this way the propulsion element is secured against rotating, connected or coupled to the housing via the intermediate member.

0047The intermediate member is preferably located in a floating position between the first spring and the second spring, which means that the position of the link is such that the force exerted by the first spring and the second spring to the intermediate member forces cancel each other out.

0048For example, the first compression spring surrounding the driving member and the second compression spring surrounding the spurring member. This means that the first compression spring and the second compression spring may be disposed in the annular gap between the inner sleeve of the housing and the propulsion member. For example, the outer diameter of the first pressure spring may be larger than the outer diameter of the second compression spring. This can be optimized in terms of a space-saving design with the first pressure spring with respect to a high spring constant and to the second pressure spring.

0049For example, the first compression spring surrounding the driving member and the driving member surrounding the second compression spring. The first pressure spring may be disposed in the annular gap between the housing, in particular of the inner sleeve, and the tunneling member. The second compression spring may be disposed in the annular gap between the rotary member and driving member. This allows at least for the area in which the second compression spring is arranged, achieve a space-saving design.

0050The intermediate member may extend through an elongated and extends along the longitudinal axis extending slot in the wall of the tubular driving member. The slot can thereby simultaneously serve as a guide or as a longitudinal guide for the intermediate member to the driving member. The first spring can be supported on the member of the intermediate portion which is located outside the propulsion member, wherein the second compression spring can be supported on the portion of the intermediate member itself, which is located within the driving member. The intermediate member is or will be displaced during the product distribution in the slot or shifted.

0051Generally preferred are the second compression spring distally of the first compression spring is arranged. In particular, the distal end of the first compression spring the proximal end of the second compression spring may be disposed distally.

0052The second compression spring may preferably have a smaller outer diameter than the inner wall of the product container, on which the piston of the product container abuts slidably. Due to the small outer diameter can be advantageously achieved that an accidental contact of the spring is prevented by a sufficient distance from the inner wall.

0053The second compression spring may be arranged so that it is located in the product container when the piston rod for distribution of the product is shifted to the product container.

0054The intermediate member may be adjusted in relation to the product container with respect to its position so that it is spaced along the longitudinal axis from a proximal end of the product container or the proximal end of the product container touched when the from the product container maximum distributable amount of product is distributed. If the connecting rod does not touch the proximal end of the product container during product delivery, it is ensured that both compression springs contribute to drive the plunger. If the intermediate member comes into contact with the distal end of the product container during product delivery, only the second compression spring may contribute to the distribution, which may well be of advantage in particular applications.

0055In a second sub-aspect may have a shoulder, the propulsion member, on which a spring, in particular with its distal end is supported at least. The at least one spring may be a single compression spring, that is, a spiral spring acting as a compression spring to be. A distally of the shoulder along the longitudinal axis extending portion of the propulsion member may comprise a measured along the longitudinal axis length which is greater than the existing between the proximal end of the product container and the piston distance when the piston is in the position in which the in the product container maximum distributable amount of product is distributed. In this embodiment may be arranged only in the area proximal to the shoulder, the compression spring need be being arranged in the area distal to the shoulder no further spring. This can be especially beneficial to ensure that the area can be designed to save space distal to the shoulder.

0056In particular, the shoulder in a rotationally fixed and axially displaceable engagement with the housing can be. For example, the shoulder firmly connect an inner sleeve of the driving member and an outer sleeve of the driving member, said at least one pressure spring may be disposed in the annular gap formed between the inner sleeve and the outer sleeve or is. For example, may be the outer sleeve in a rotationally fixed and axially displaceable engagement with the housing, in particular the inner sleeve of the housing or the guide. In this way, a rotation of the driving member is prevented relative to the housing, but a displacement along the longitudinal axis allowed.

0057In a third sub-aspect, the at least one spring, a torsion spring, in particular, be a spirally wound ribbon-like material from a spring which is supported on the rotary member and the abutment. Such a spring may be referred to as a spiral or clock spring. The prestressed torsion spring generates a torque between rotary member and the abutment, the torque being tried that rotary member to rotate relative to the abutment or the housing about the longitudinal axis. The torsion spring and preferably also the abutment for the torsion spring, on which supports the torsion spring, may be one to the housing along the longitudinal axis of sliding bearing element, which is provided with a dosage indicator member in a threaded engagement, arranged relative a dose display element and / or distally. For the embodiment of the dose display element and the bearing element is made to the rest of the specification of this application.

0058In the third sub-aspect, the rotation member may be rotatably and axially slidably connected to the propulsion member. The rotary member may be a sleeve-like, for example, and surrounded the propulsion member. The propulsion member and the rotary member may be connected so that the rotary member in a rotationally fixed with respect to the driving member and is axially displaceable. The propulsion member may then be, for example, with its external thread in a threaded engagement with the housing or a housing-fixed member. Upon rotation of the rotary member, the driving member is screwed to the thread of the housing or the housing-fixed member along the longitudinal axis, whereby the recordable product distribution can be made, ie, the piston can be moved in the product container in the distal direction.

0059Characterized in that the rotary member surrounds the driving member, the driving member may, for example, rod-shaped, in particular designed as a piston rod, whereby it maintains a sufficient distance from the inner wall of the product container when the propulsion member is displaced into the product container.

0060Generally preferred are the angle of rotation of the rotary member may be proportional to the delivery stroke of the piston or of the propulsion member. This can be achieved by selectively blocking or releasing the rotary member.

0061Advantageously, the rotary member may be in engagement, in particular a threaded engagement with the driving member. By the thread pitch of this thread engagement is achieved that such. As relative to the housing, the propulsion member is displaced from the dispensing spring by a stroke in one complete revolution of the rotary member, which corresponds to the thread pitch.

0062For example, the rotary member can be a threaded rod and the driving member having a threaded nut or be, the thread of the threaded nut engages in the thread of the threaded rod.

0063In an alternative example, the rotation member is a threaded nut and the propulsion member may comprise a threaded rod or with the thread of the threaded nut engages in the thread of the threaded rod.

0064Preferably, the rotary member is axially fixed with respect to the housing or may at least in one, preferably in the distal direction axially fixed to the housing or a housing-fixed member, such as. For example, support the abutment.

0065It is advantageous that the rotary member during setting of a dose, that is connected to the housing in the unactuated state, in particular by means of the at least one clutch, in particular a rotationally fixed manner to a first clutch and, during the actuation of the device for dispensing the product dose is rotated relative to the housing is or rotatable. The dose display element, in particular the dose indicator barrel may optionally be in a threaded engagement with the housing or a housing-fixed member.

0066The dose indicator, in particular the dose indicator barrel may be damaged during setting of a dose, that the drive and metering device or of the actuator to be rotatable relative to the rotary member in the unactuated state. Preferably, the dose indicating member during actuation of the device relative rotation with respect to pouring of the product dosage to the rotary member and, for example, movable axially or in rotation with the rotary member connected, in particular with the at least one clutch, in particular a second clutch.

0067Advantageously, causing at the dose distribution, that is, during the actuation of the actuator, the dispensing spring, the dosage indicator member back screwed to its zero dose position, in particular via the rotary member, preferably via a coupling member which is preferably arranged rotationally fixed but axially displaceable with respect to the dose display element. In particular, the coupling member and the dose indicator element in a rotationally fixed engagement can be that permits axial movement between the dose display element and coupling member. This intervention can, for. Instance, be effected by means of a longitudinal guide. Preferably, the coupling member is axially fixedly but rotatably to the bearing element.

0068The first clutch may be disposed kinematically between the housing, in particular the bearing element, and the rotary member. The first clutch is engaged during adjustment of the product dose or in the non-actuated operating member, whereby the rotary member is rotationally fixed relative to the housing. During product distribution or operated actuator, the first clutch is disengaged, whereby the rotary member is rotatable relative to the housing.

0069The first clutch may include a first coupling structure, which is rotationally connected to the housing, is formed in particular by the housing or the bearing element, and a second coupling structure that rotationally connected to the rotary member, in particular formed by the rotary member having. The first coupling structure may be a set of teeth or have, wherein the second coupling structure may be or include a gearing. The toothings of the first coupling structure and the second coupling structure may engage form-locking in the engaged first clutch. The first coupling structure may be an external toothing, wherein the second coupling structure may be an internal toothing. Alternatively, the first coupling structure may be an internal toothing, wherein the second coupling structure may be an external toothing.

0070The second clutch may be disposed between a sleeve-shaped coupling member which is connected, for example rotatably and axially to the bearing element, in particular can be in an engaged, and the rotation member. The second clutch is disengaged during adjustment of the product dose or in the non-actuated operating member, whereby the coupling member is permitted to be rotated relative to the rotary member. While the product delivery or operated actuator, the second clutch is engaged. Hereby is achieved in particular in that the rotary member and the coupling member are rotationally connected. The coupling member may thus be rotated by the rotary member. The second clutch, a third clutch structure which is secured against rotation is connected to the coupling member is in particular formed by the coupling member and a fourth coupling structure that is rotationally connected to the rotary member, in particular formed by the rotary member, include. The third coupling structure may be a set of teeth or have, said fourth coupling structure may be or include a gearing. The teeth of the third and fourth coupling structure can form-fitting mesh when the second clutch is engaged. For example, the third coupling structure may be an internal toothing, wherein the fourth coupling structure may be an external toothing. Alternatively, the third coupling structure may be an external toothing, wherein the fourth coupling structure may be an internal toothing.

0071Basically, the teeth for the second coupling structure and the fourth coupling structure may be separate from each other toothings. Preferably, the second coupling structure and the fourth coupling structure may be formed by a common gearing.

0072Specifically, the first and the second clutch can be coordinated so that the actuating member between the unactuated position and the actuated position can assume a, for example, first intermediate position, in which the first clutch is engaged and the second clutch is engaged. This advantageous effect that the rotation of the coupling member is released only by the drive spring, when it is ensured that the rotary member rotatably coupled to the coupling member. This advantageously avoids a malfunction of the device, which could occur when the second clutch is not engaged and the first clutch is already disengaged.

0073The drive and metering device preferably includes a third clutch which is arranged between the dosage setting member and the coupling member. The third clutch is engaged during adjustment of the product dose or in the non-actuated operating member, whereby the coupling member and the dosage setting member are secured against rotation in relation to each other. During product distribution or operated actuator, the third clutch is disengaged, whereby the coupling member is rotatable relative to the dosage setting member by means of the pre-stressed drive spring.

0074The third clutch, a fifth clutch structure which is rotationally connected to the dosage setting member, in particular is formed by the dosage setting member, and a sixth coupling structure which rotationally connected to the coupling member is in particular formed by the coupling member comprise. The fifth coupling structure may be a gear or have, said sixth coupling structure may be or include a gearing. The teeth of the fifth coupling structure and the sixth coupling structure can form-fitting mesh when the third clutch is engaged. The fifth coupling structure may be an internal toothing, wherein the sixth clutch structure may be an external toothing. Alternatively, the fifth clutch structure may be an external toothing, wherein the sixth clutch structure may be an internal toothing.

0075Specifically, the first and the third clutch can be coordinated so that the actuating member between the unactuated position and the actuated position can assume a, for example second, intermediate position, in which engaged, the first clutch and the third clutch are engaged.

0076Preferably, the drive and metering device may comprise a fourth clutch which is interposed between, and in particular arranged kinematically between the dosage setting member and the housing. The fourth clutch is disengaged during adjustment of the product dose or in the non-actuated operating member, whereby the dose setting member is rotatable relative to the housing. During product distribution or actuated actuating member, the fourth clutch is engaged, whereby the dose setting member is rotationally fixed relative to the housing. Generally it is preferred that the dosage setting member is rotationally fixed while the product distribution relative to the housing.

0077The third clutch, a seventh coupling structure which rotationally connected to the housing, in particular formed by the housing and an eighth coupling structure which rotationally connected to the dosage setting member, in particular of the dosage setting member or to the actuating member which permanently rotationally fixed, for example with the dose setting member may be connected, is formed having. The seventh coupling structure may be a gear or, said eighth coupling structure may be or include a gearing. The teeth of the seventh coupling structure and the eighth coupling structure can engage positively locking in the engaged third coupling. The seventh coupling structure may be an external toothing, wherein the eighth coupling structure may be an internal toothing. Alternatively, the seventh coupling structure may be an internal toothing, wherein the eighth coupling structure may be an external toothing.

0078In general preferred embodiments such. As can the dose indicator has a stop, have a zero dose stop which is moved away from a counter-stop, in particular a zero dose counter stop if a dose increase is made, and is moved towards the counter-stop, when a dose reduction shall be made or if the device is operated for the distribution of the set product dose.

0079In particular, the dose indicator can while adjusting the product dosage, ie increasing the dose and dose reduction, be decoupled at least in rotation of said rotary member and be for dispensing the dose of product as coupled with the actuation of the device with the rotary member such that rotation of the rotary member causes the dose indicator to the counter-stop, that is the zero dose stop is moved to the zero dose counter stop out. Are the zero dose stop and zero dose counter stop in a stop or a contact is thereby prevented and in particular via the second clutch, a rotation of the rotary member and thus a further advancement of the driving member relative to the housing.

0080In advantageous developments, the drive and metering a mechanism for preventing setting of a dose which exceeds the amount of drug in the product container comprise. In particular, this mechanism can block the rotation of the dosing member in a direction which would cause an increase in dose, in particular also when the maximum dose stop of the dose display element and the maximum dose counter-stop are not yet in engagement, or when in the pointing device, a dose will be displayed which is smaller than the maximum adjustable product dosage. The mechanism thus prevents a dose can be adjusted, which exceeds the remaining quantity of the product contained in the product container, whereby the risk of misuse of the drive and metering device is reduced. The mechanism may, for. Example, have a limiter which is mounted between two parts, one of which rotates relative to the other during dose titration and, that is, the dose distribution does not rotate during actuation. For example, the limiter between the dosage setting member, which can in particular be configured as a dose setting knob or dose dial sleeve, and the housing or a housing-fixed member may be arranged. The limiter, the dosage setting member and the housing can be coupled to each other so that a relative rotation, in particular during dose setting, between the dosage setting member and the housing causes the limiter to a stop position moved toward, wherein the limiter prevents setting of a dose which exceeds the amount of a product in the product container. Examples of suitable limiters accordingly be in the<patcit id="pcit0002" dnum="WO2010149209A"><text>WO 2010/149209</text></patcit> or in the <patcit id="pcit0003" dnum="WO0119434A1"><text>WO 01/19434 A1</text></patcit>, In particular in the <figref idrefs="f0003">figure 3</figref> disclosed. For example, the limiter having an internal thread which is in engagement with an external thread of the housing. In particular, the limiter may have on its outer side a longitudinal guide with which it is in engagement with the dose setting member, such that the dosage setting member is relatively rotatably to the limiter. Alternatively, the housing having longitudinal guide for the limiter, so that the limiter relative to the housing is rotationally fixed and the limiter can a thread, in particular having external thread which engages a thread, in particular internal threads of the dosage setting member.

0081The stop position is defined by a stop for the limiter, the stop can be formed by the housing or the dosage setting member or a housing-fixed at least axially or circumferentially means. Are the limiter and the abutment in a contact, rotation of the dose setting member is in a rotational direction which would cause an increase of the dosage no longer possible or blocked.

0082In general preferred developments, in particular the first and second aspects, the drive and metering may comprise at least one signal generation mechanism which is adapted to the dose setting and / or the product distribution to be produced during an audible and / or tactile signal, in particular mechanically,. Such a signal can be in particular recognized as a click signal. For example, a (first) signal generation mechanism can be provided which can be the signal generated during dose titration and optional called Dosierklickeinrichtung. Further, another (second) signal generating mechanism may be provided, which can be the signal generated during the product distribution and, optionally, referred to as Ausschüttklickeinrichtung. Alternatively, a (common) signal generation mechanism can be provided which generates the signal during dose titration and during product delivery.

0083The signal generating mechanism may be located generally between two parts that move relative to each other during dose setting and / or the product distribution, especially turning. One of the parts can comprise, for example a resiliently arranged locking member, engages in the a z. B. over the circumference arranged teeth of the other of the two parts. If a part is rotated relative to the other, the latching element can slide over the teeth and thereby generate the signal. The teeth may be formed from an inner periphery or an outer periphery or an end surface of the part.

0084The signal generating mechanism for dose adjustment can be particularly formed between coupling member and support member or rotating member. Preferably, the coupling member rotates relative to the bearing element or the rotary member, whereby a signal generating mechanism is formed, which produces the signal during dose setting during dose setting. The coupling member, the latching member and the rotary member or the bearing element, the toothing, in which engages the locking member form. The teeth may be the gearing eg. B. forming the second and / or fourth coupling structure.

0085The signal generation mechanism of the product distribution may be particularly formed between coupling member and actuator or dosing. For example, the actuator the toothing, in particular internal toothing, and the coupling member or rotationally fixed to the coupling member connected clicker form the locking member. Preferably, rotates the coupling member, while, in particular, only during the product distribution relative to the operating member or the dose member, whereby a signal generating mechanism is formed, which produces the signal during the product distribution.

0086The invention has been described with reference to several advantageous embodiments. In the following, advantageous embodiments are described with reference to figures. The features disclosed herein form the subject of claims, in particular the independent claims, especially individually and in any combination with the claims or / and the foregoing description, advantageously develop. Show it:<dl id="dl0001" compact="compact"><dt>figure 1</dt><dd>different views of a first embodiment of a drive and metering device according to the invention,</dd><dt>figure 2</dt><dd>different representations of a second embodiment of a drive and metering device according to the invention, </dd><dt>figure 3</dt><dd>different views of a third embodiment of a drive and metering device according to the invention and</dd><dt>figure 4</dt><dd>different views of a fourth embodiment of a drive and metering device according to the invention.</dd></dl>

0087The drive and metering device comprises according to the first to fourth embodiments, a sleeve-shaped housing 4 having an outer sleeve 4b, which is by the user with one hand can be gripped. The housing 4 further comprises an inner sleeve 4a, which forms an abutment 4i and is arranged concentrically to the outer sleeve 4b. Inner sleeve and outer sleeve 4a 4b are connected to one another via an annular web. 4a between the outer sleeve 4b, and the inner sleeve an annular gap is formed, in which a dose display element 10, which in particular as a dose indicator barrel, that is configured sleeve-shaped, a bearing element 9 and a coupling member 2, which is sleeve-shaped and can be particularly referred to as display clutch disposed, are.

0088At the distal end of the housing 4 is a sleeve-shaped product container receptacle 5 is arranged from a preferably transparent material, in which a product container 14 is received in the form of a carpule. The product container 14 is connected by means of the product container receptacle 5 unreleasably to the housing 4 so that the drive and metering in particular together with the product container receptacle 5 and the product container 14 constitutes a disposable injection device which is discarded after complete emptying of the product container 14 as a whole. The product container 14 has at its distal end to a septum 14b, which can be attached by a distal through the end of the product container 14 or the product container receptacle 5 needle is pierced. In the product container 14, a piston 14a accommodated, wherein the distributable product between the septum and the piston 14b is arranged 14a. A displacement of the piston 14a toward septum or in the distal direction, thus dispensing direction, triggers the release of the product contained in the product container 14th There may be a cap (not shown) may be provided which is mountable on the product container receptacle 5, and is removed prior to the injection of a dose.

0089The drive and metering device comprises a driving member and a rotary member 8 first The propulsion element 8 is arranged such that a distal end 8g act on the piston 14a, in particular against the piston 14a can push. The rotary member 1 is axially fixed relative to the housing 4 and rotatable about the longitudinal axis L. The rotary member 1 and the driving member 8 are coupled to one another or engage in one another such that rotation of the rotational member 1 relative to the housing 4 and / or to the driving member 8, a movement of the driving member 8 along the longitudinal axis L in the distal direction to shift the piston 14a causes.

0090The rotary member 1 has at its proximal end to an enlarged diameter, in particular in the form of a widened head. At the head of an external toothing are arranged parallel to the longitudinal axis L forming teeth, which serve as second and / or fourth coupling structure 1b as will be described below. On the head, an annular, from diametrically opposite the head reduced friction surface is arranged with a protruding into contact inwards, for example, an abutment is 4i forming annular web of the housing. 4 Due to the reduced diameter of the annular friction surface of the point of application of the resultant force is displaced closer to the longitudinal axis L out, whereby the friction torque between the rotary member 1 and housing 4 is reduced.

0091The drive and metering device according to the first to fourth embodiment, at least a dispensing spring 11; 11a, 11b. The at least one dispensing spring 11; 11a, 11b is in the delivery, that is so strongly biased in the delivery state of the drive and metering that sufficient energy stored in it, completely throwing out the product contained in the product container 14 substantially, especially with several individual distributions between each new dose adjustment is made. The advantage of the at least one prestressed spring 11; 11a, 11b is that the at least one spring 11; 11a, 11b, for example, must not be stretched during dose titration, whereby a power-saving, ie simple dose adjustment can be undertaken for the user of the device.

0092The at least one dispensing spring 11; 11a, 11b is formed as a helical or spiral spring in the first to third embodiments, which acts as a compression spring and strives the abutment 4i and the driving member 8 to press apart, that is, the driving member 8 in the distal direction relative to the housing 4 to move.

0093The housing 4, in particular the inner sleeve 4a and a sleeve-shaped driving member 8, which can also be referred to as a follower are rotationally fixed relative to each other and axially slidably coupled. The propulsion member 8 is rotationally fixed relative to the housing 4 and axially displaceable along the longitudinal axis L.

0094The rotary member 1 is formed as a threaded rod, forming an external thread 1a and is provided with an internal thread of the sleeve-shaped driving member 8 in a threaded engagement. The pitch of the thread of the threaded engagement between the driving member 8 and the rotary member 1 is so great that no self-locking of the threaded engagement occurs, that is, the rotary member 1 due to the force acting along the longitudinal axis L of axial force of the dispensing spring 11relativ to the driving member 8 about the longitudinal axis L rotatable or rotatable.

0095The housing 4, in particular the proximal end of the inner sleeve 4a forms the abutment 4i for the at least one dispensing spring 11; 11a, 11b, which is supported on the abutment 4i and the area of ​​the distal end of the tunneling member eighth The at least one spring 11; 11a, 11b is in the third embodiment (<figref idrefs="f0003">figure 3</figref>) A single spring and in the first and second embodiments (<figref idrefs="f0001">figures 1</figref> and <figref idrefs="f0002">2</figref>) A first spring 11a and a second spring 11b. The first spring 11a and second spring 11b are connected in series.

0096In the third embodiment (<figref idrefs="f0003">figure 3</figref>) Supports the spring 11 with its distal end to an annular web, in particular the shoulder 8g, the propulsion element 8 from which firmly connects an outer sleeve and an inner sleeve 8b of the propulsion member. 8 The spring 11 is supported at its proximal end to the housing 4 and formed by inwardly projecting annular web, which forms the abutment 4i. The spring 11 is disposed in the annular gap between the outer sleeve and the inner sleeve propulsive 8b of the member 8 at least partially. The inner sleeve propulsive 8b of the member 8 has the inner thread 8c for threaded engagement with the rotary member the first The propulsion member 8, in particular the outer sleeve and the housing 4, in particular the inner sleeve 4a engage into each other so that the driving member 8 is rotationally fixed relative to the housing 4 about the longitudinal axis L and is displaceable along the longitudinal axis L. 4a between the inner sleeve and the driving member 8 and the outer sleeve is a guide by at least one longitudinal rib 8a and at least one longitudinal guide 4c formed which prevents rotation of the driving member 8 relative to the housing 4, and an axial movement of the driving member 8 relative to the casing 4 allowed. The longitudinal rib 8a is preferably formed by the outer sleeve of the driving member. 8 The propulsion member 8 has the inner sleeve 8b which the inner thread 8a in this example has at its proximal end which engages in the outer thread 1a of the designed as a threaded bar rotating member first

0097The annular web, in particular the shoulder 8g, of the propulsion member 8 is based on the measured along the longitudinal axis L total length of the driving member 8 in the proximal half, in particular in the proximal third of the driving member 8 is arranged. The measured along the longitudinal axis L distance between the distal end of the driving member 8 and the annular rib of the driving member 8 is preferably greater than the distance measured along the longitudinal axis L distance between the piston 14a and the proximal end of the product container 14 when the piston 14a in the position is, in which the product from the container maximum distributable amount of product is distributed, ie essentially completely empty product containers. This prevents advantageous that the annular rib abuts against the proximal end of the product container 14 or at least moved into the product container fourteenth

0098In the first and the second embodiment (<figref idrefs="f0001">figures 1</figref> and <figref idrefs="f0002">2</figref>) When the first spring 11 having its proximal end attached to the annular web formed by the housing 4 and projecting inwardly from, which forms the abutment 4a. The spring 11 is supported at its distal end to a particular annular, the spurring member 8 preferably surrounding intermediate member 11c. The second spring 11b is supported at its distal end to an annular rib or annular collar, for example in the area of ​​the distal end 8d of the driving member 8 from. The second spring 11b is supported with its proximal end to the intermediate member 11c. The intermediate member 11c couples the driving member 8 and the housing 4 so that the driving member 8 is slidable relative to the housing 4 along the longitudinal axis L and against rotation about the longitudinal axis L. The intermediate member 11c and the inner sleeve 4a of the housing 4 engage each other so that the intermediate member 11c in a rotationally fixed and axially displaceable in relation to the housing. 4 The intermediate member 11c and the driving member 8 engage each other so that the intermediate member 11c slidable relative to the driving member 8 along the longitudinal axis L and to the longitudinal axis L is rotationally fixed.

0099The second spring 11b has an outer diameter which is smaller than the outer diameter of the first spring 11a. This can ensure that the area of ​​the propulsion member 8 and the first spring 11b, which is shifted the product distribution in the product bin 14 has sufficient spacing from the piston 14a leading the inner wall of the product container fourteenth The proximal end of the second spring 11b is disposed distally of the distal end of the first spring 11a.

0100The intermediate member 11c is arranged so that it is spaced along the longitudinal axis L from a proximal end of the product container 14 when the from the product container 14 maximum distributable amount of product is distributed, that is, at substantially completely empty product container 14. This ensures that the first and second springs 11a, 11b are involved until full product delivery on Ausschüttprozess.

0101In the first embodiment surrounds the first spring 11a, the propulsion member 8, wherein the second spring 11b, the driving member 8 surrounds. In other words, the first spring 11a and second spring 11b are arranged in the annular gap formed between the driving member 8 and the inner sleeve 4a of the housing 4th This arrangement allows a particularly simple mounting of the drive and metering.

0102In the second embodiment (<figref idrefs="f0002">figure 2</figref>) Surrounds the first spring 11a, the propulsion member 8, wherein the propulsion member 8 surrounds the second spring 11b. The first spring 11a is otherwise expressed in the annular gap between the inner sleeve 4a and the driving member 8 is arranged. The second spring 11b is arranged in the annular gap formed between the rotary member 1 and the spurring member eighth The sleeve-shaped driving member 8 has at least one elongated, parallel to the longitudinal axis L extending slot 8f, through which the intermediate member 11c engages and in which the intermediate member 11c is displaced. Advantageously, the first spring 11a and second spring 11b can be supported on the intermediate member 11c. The slot 8f can advantageously serve for the rotationally fixed and axially movable engagement of the link 11c with the driving member. 8

0103In that in <figref idrefs="f0004">figure 4</figref> fourth embodiment shown, the rotary member 1 sleeve-shaped and surrounds the elongate, in particular as a threaded rod formed spurring member 8. The driving member 8 and the rotary member 1 reach inside each other so that the driving member 8 with respect to the rotational member 1 rotatably about the longitudinal axis L and along the longitudinal axis L is displaceable. The propulsion member 8 has an outer thread which is in threaded engagement with an internal thread of the housing. 4 Rotation of the rotational member 1 relative to the housing 4 causes rotation of the driving member 8, whereby the driving member 8 is screwed onto the housing 4 along the longitudinal axis L.

0104The spring 11 is in the fourth embodiment of a band-shaped material spiral coiled spring acting as a torsion or torsion spring. Such springs are also referred to as a watch springs.

0105The spring 11 is supported with one end on the rotary member 1 and the other end to the housing 4 or the housing-fixed housing insert which forms the inner sleeve 4a decreases. The inner sleeve 4a is connected by an annular web with the housing 4 and the outer sleeve 4b, with the spring 11 distal to the annular web is disposed. The spring 11 is in particular distally of a dosage indicator member 10 and / or a bearing element 9 is arranged. The bearing element 9 and / or the dose display element 10 are disposed proximally of the annular web. The spring 11 is disposed between the annular web connecting the inner sleeve to the outer sleeve 4a 4b and the annular web, which aufwiest the internal thread for the threaded engagement with the driving member eighth This arrangement allows particularly advantageous that the torque generated by the spring 11 is passed directly as possible to the product during distribution in the driving member. 8

0106Particularly preferably, the outer diameter of the spring 11 is greater than the inside diameter 4a of the sleeve-shaped portion.

0107It is again a general reference to the first to fourth embodiments. By rotating the rotational member 1 relative to the housing 4 and the driving member 8, the spring 11 can move the driving member 8 by a delivery stroke in the distal direction which is proportional to the rotation angle of the rotary member the first By selectively blocking and releasing the rotary member 1, which can be effected by pressing a configured as operating knob actuator 7, the movement of the driving member 8 relative to the housing 4, ie the delivery stroke of the driving member 8 are controlled in an advantageous manner.

0108The drive and metering device further has a bearing element 9, which can also be referred to as a display drum bearing member and relative to the housing 4 in a rotationally fixed but along the longitudinal axis L is slidably disposed. The bearing element 9 is sleeve-shaped and preferably surrounds the inner sleeve 4a of the housing 4, whereby in particular the outer sleeve surrounds the support member 4b. 9 The bearing element 9 is prevented in an engagement with the housing 4, in particular the inner sleeve 4a, which permits a longitudinal movement of the bearing element 9 relative to the housing 4, but a rotary motion. The procedure can be formed by a longitudinal guide 9f between the bearing element 9 and the inner sleeve 4a.

0109The bearing element 9 has a thread 9a, in particular an external thread, into which a thread 10e, in particular an internal thread, the dose indicator member 10 engages. By this threaded engagement, the display element 10 is relatively screwed to the bearing element. 9

0110The illustrated embodiments comprise a signal generating mechanism for dose adjustment (Dosierklickeinrichtung) and a signal generating mechanism for delivering the product (Ausschüttklickeinrichtung), each generating an audible and / or tactile signal when the dose setting or in the product distribution.

0111The Ausschüttklickeinrichtung has an annular clicker 15, which is arranged in the operating member 7 and having a locking member which are in an extending over the circumference of inner teeth resilient or resiliently engages 7b of the operating member 7 .. The clicker 15 and the coupling member 2 in a non-rotating about the longitudinal axis L engagement, so that the clicker 15 is rotated from the coupling member 2 when the coupling member 2 is rotated relative to the housing 4 about the longitudinal axis L. Rotation of the sleeve-shaped coupling member 2 relative to the housing 4 and / or the actuator 7 causes the locking member of the clicker 15 snaps over the internal teeth 7b and thereby generates the audio and / or tactile signal.

0112The Dosierklickeinrichtung comprises a on the coupling member 2 formed resiliently engaging member which engages in the outer toothing, which forms the second coupling structure 1b. The coupling member 2 rotates during dose setting relative to the rotary member 1, whereby the locking member 2c engaged about the second coupling structure 1b, thereby generating the audible and / or tactile signal during dose setting. The external toothing is designed, in particular, the distance between the teeth that they and the setting of discrete dose-proportional angular steps and / or the generation of a slight resistance at the dose adjustment and / or the generation of audible or tactile signal, such as an audible tactile clicks when the dose setting enables

0113The dose display element 10 is non-rotatably but axially displaceably connected to the coupling member 2, in particular in an engaged. This engagement comprises a longitudinal guide 2a, which causes the dose indicator member 10 relative-rotatably to the coupling member 2, but is axially displaceable. A rotation of the coupling member 2 relative to the bearing element 9 causes, due to the rotationally fixed connection between the coupling member 2 and dosage indicator member 10, that the dosage indicator member 10 is also rotated and is screwed due to the threaded engagement in the thread 9a of the bearing element 9 along, in particular in addition to the result of the latches generated clicks.

0114The dose indicator 10 has on its outer periphery on a correspondingly the pitch of the thread 10e helically ersteckende dose scale, comprising a plurality of successively arranged scale values. In the example shown can be adjusted with the drive and metering a maximum dose of 80 IU, the scale of 0 to 80 range and the dose values ​​are given in increments of two.

0115The dose indicator 10 has at its proximal end as a pioneering and circumferentially acting stop surface, which is referred to as zero dose stop. The dose indicator 10 has at its, for example the proximal end opposite, distal end a forwardly and circumferentially acting stop surface on which is referred to as maximum dosage stop.

0116The Dosisanzeigelement 10 is secured to the bearing element 9 between a zero dose position and a maximum dose position back and forth screw. In the zero dose position of the zero dose stop prevented in cooperation with a carrier formed from the housing 4 zero dose counter stop the rotation of the dose display element 10 in a first rotational direction, namely a direction of rotation that would cause a smaller dose than zero is set. In this zero dose position, the dose indicator element 10 in the opposite, ie, the second direction of rotation rotatable.

0117In the maximum dose position of the maximum dosage stop prevents the interaction with a maximum dose counter stop, which is formed by the bearing element 9, the rotation of the dose display element 10 in the second rotational direction, which would cause an increase in the dose above the maximum configured value addition. The rotation in the first rotational direction is possible in the maximum dose position. Although the maximum dose counter stop is formed by the bearing element 9, can be differently optionally formed by this example, the maximum dose counter stop of the housing. 4 The zero dose counter stop can be differently formed from the illustrated example of the bearing element. 9

0118The housing 4 has a pointing device 4d in the form of a window on which gives a view of the scale of the dose display element 10 free. On the housing 4 a dosing member 3 is rotatably supported but axially fixed in the form of a dosing button. For this purpose, the housing 4 has an annular groove 4g, into which in particular engages an annular shoulder of the dosing third The dosing member 3 has on its outer circumference a handle structure 3b, which makes it easier for the user of the device, the dosing member 3 to rotate relative to the housing. 4 In the unactuated state of the device a rotation of the dosing member 3 causes rotation or screwing movement of the dosage indicator member 10, so that the desired dose is set and in the pointing device 4d read.

0119At the dosing member 3, an actuator 7 is arranged in the form of an actuating button, which to the dosing member 3 for actuation of the device to the product distribution is relatively movable, in particular along the longitudinal axis L. The operating member 7 forms the proximal end of the device and by the thumb the hand of the user which grips the housing 4, operable in a simple manner, in particular relative to the housing 4 and / or to the dosing member 3 slidably. The coupling member 2 is fixed relative to the actuator 7, in particular in dissolved Dosierkupplung 2b, 3c, rotatably and axially. Preferably, the actuator 7 is axially fixed but rotatably snapped with the coupling member. 2

0120The drive and metering device further comprises a reset or clutch spring 12 which is tensioned during the pressing, in particular pressures of the actuating member 7, and which resets the bearing element 9 and / or the operating member 7 in its inoperative position when the actuating member 7 is unconfirmed. An operation of the actuator 7 causes besides its axial displacement also the axial displacement of the bearing element 9 along the longitudinal axis L. The spring 12 is supported at its distal end, preferably at the dosing member 3 and with its proximal end preferably to the actuator 7 from. The spring 12 is preferably a helical or spiral spring acting as a compression spring.

0121The dosing member 3 is rotationally fixed relative to the actuator. 7 The actuator 7 engages through an inwardly protruding shoulder of the dosing member 3. At the distal end of the preferably pot-shaped designed actuator 7 is an eighth coupling structure 7a formed in the form of an external toothing, which 7 4h by operation of the actuator with a formed on the housing 4 seventh coupling structure is coupled in the form of an internal toothing, in particular at the proximal end of the housing 4, into engagement, whereby the dosing member 3 is rotationally fixed with respect to the housing. 4 This causes in-actuated device comprises a dose setting, ie a rotation of the dosing member 3 to the housing 4 is relatively not possible, but only when the actuator 7 is unconfirmed. The seventh and eighth coupling structure 4H, 7a form a fourth clutch 4H, 7a.

0122Between the dosing member 3 and the coupling member 2, a third clutch 2b, 3c is formed, the dosing member 3 forms a sixth clutch structure 3c of the third clutch 2b, 3c, in particular on the inwardly projecting shoulder. The sixth coupling structure 3c is engaged in the non-operated actuator 7 in rotation to a formed as an external toothing on the coupling member 2 fifth clutch structure 2b of the third clutch 2b, 3c. In the non-actuated state of the actuator 7, the third clutch 2b, 3c is engaged. The third clutch 2b, 3c can be referred to as Dosierkupplung that at the dose setting, that is engaged in the non-actuated actuating member 7 and and at the dose distribution, that is disengaged when actuated actuator 7, wherein the third clutch 2b, 3 transmits torque in the coupled state when disengaged does not transmit torque. The third clutch 2b, 3c is disengaged by a displacement of the coupling member 2 relative to the housing 4, in particular due to the operation of the actuator. 7

0123The bearing element 9 has, at its proximal end on the inner circumference to a first coupling structure 9e which is formed by means disposed on the periphery of inner toothing, which are connected to the second coupling structure 1b forming toothing of the rotary member 1 in an engaged, in particular in the non-actuated actuating member. 7 the first coupling structure 9e and the second coupling structure 1b constitute a first clutch 1b, 9e. If the clutch structure 9e, interlock 1b, ie, the clutch 1b, 9e is engaged, the rotary member 1 is rotationally fixed in relation to the housing. 4 The coupling member 2 further comprises a third clutch structure 2d to an inner periphery, which has a arranged over the circumference of inner toothing. The third clutch structure 2d is arranged so that it passes upon actuation of the actuator 7 in a rotationally fixed engagement with the rotary member 1, in particular with the second coupling structure 1b or, alternatively, a separate from the second coupling structure 1b, but not shown in these examples, the fourth coupling structure , The third clutch structure 2b and second or fourth clutch structure 1b form a second clutch 1b, 2d.

0124While the operating member 7 is shifted for actuation relative to the dosing member 3 along the longitudinal axis L, in addition, the second clutch 1b, 2d is engaged. By further displacement of the actuating member 7 relative to the dosing member 3, the first clutch 1b is engaged 9e. Before, after or simultaneously with the disengagement of the first clutch 1b, 9e, the third clutch 2b, 3c is disengaged. and / or the fourth clutch 4H, 7a engaged.

0125In particular in that the first coupling structure 9e is disengaged from the second coupling structure 1b, the at least one dispensing spring 11; 11a 11b, relax, whereby the rotary member 1 is rotated relative to the housing 4 and due to the engagement of the second clutch structure 1b with the third coupling structure 2d, the coupling member 2 and thus the dose display element 10 can be rotated relative to the housing 4, whereby the dose indicator 10 screwed to its zero dose position and the propulsion member 8 to extending distance between zero dosage stopper 10c and zero dose counter stop 4f is moved to a delivery stroke relative to the housing 4 in the distal direction proportional particular circumferentially. The rotation of the coupling member 2 causes relative to the operating member 7, that the locking members of the clicker 15 7b via the teeth rest in particular in a dose-proportional angular increments and thereby produce the audible and / or tactile signal.

0126The drive and metering device comprises a Dosisbegrenzer in the shape of a ring, a ring segment or a nut having on its inner circumference a thread which engages 4e in a disposed on an outer periphery of the housing 4 thread, so that the Dosisbegrenzer relative to the housing 4 can be screwed. On the outer periphery, the Dosisbegrenzer an engaging member on which engages in a longitudinal guide 3a on the inner circumference of the dosing member 3, so that the Dosisbegrenzer relative to the dosing member 3 rotatably but axially displaced. At the dosing member 3 or the housing 4 a stop lug is formed, from which the Dosisbegrenzer spaced in proportion to the maximum distributable from the product container 14 product quantity. Since the dose setting the dosing member 3 is rotated relative to the housing 4 and is not twisted at a dose distribution, a counter can be formed by the Dosisbegrenzer which adds the already released single doses and the currently set dosage and accordingly ever closer to the stop lug of dosing member 3 or the housing 4 approaches. A dose increase causes the Dosisbegrenzer is moved to the stop lug back. Dose reduction causes the Dosisbegrenzer is moved from the stop lug away. If the specified in the product container 14 remaining dose less than the maximum adjustable with the drive and metering dose unit of Dosisbegrenzer in contact with the stop means, so that a rotation of the dosing member 3 relative to the housing 4 in a direction of rotation, raising a the dose would have the consequence is blocked.

0127The system of the first clutch 1b, 9e and second clutch 1b, 2d may also be referred to as Ausschüttkupplung.

0128In the <figref idrefs="f0001 f0002 f0003">Figures 1 to 3</figref> the drive and metering device which may also be referred as an injection device, shown in its initial or delivery condition, in particular before a first use. The in the PD 4d Displaying product dosage is 0. An actuation of the actuator 7 would mean that no dose is distributed. The Dosisbegrenzer has a distance to the stop lug on which is proportional to the quantity of product contained or distributable in the product container 14 is such. As 300 IU

0129For setting the product dose, the dose setting member 3 is rotated relative to the housing 4, whereby, due to the engaged clutch third 2b, 3c, the coupling member 2 and thus the dose display element 10 can be rotated relative to the housing. 4 In this case, the dose indicator 10 screwed along the bearing element 9 due to the threaded engagement of the thread with the thread 10e 9a. In particular, the distance between the zero dose stop and the zero dose counter stop is increased in proportion to the dose 4d shown in the pointing device. In addition, provides an audible and tactile signal during the rotation due to the Überrastens the latching members via the gear teeth 1b.

0130If a maximum settable dose has been established, such as 80 IU, which are then 4d read in the PD, is a further dose escalation is not possible due to the cooperation, in particular the contact of the maximum dose stopper with the maximum dose counter stop. The Dosisbegrenzer is equivalent to 80 IU wide zoom moved or shifted to the stop lug.

0131For distribution of the set and indicated dose the actuator 7 is actuated, in particular pressed, ie relative to the housing 4 and the dosing member 3 is displaced in the distal direction, whereby the coupling member 2 and the bearing element 9 as well as the dosage indicator member 10 relative to the housing 4 in distal direction to be moved, in particular against the force of the coupling or reset spring 12th

0132The actuation of the actuator 7 causes the second clutch 1b, 2d engages and the first clutch 1b, 9e disengages, so that the rotary member 1 is no longer rotationally fixed in relation to the housing 4, but is rotatable and with respect to the coupling member 2 and the dose display element 10 is rotationally fixed. The actuation of the actuator 7 also causes the third clutch 2b, 3c disengaged and the fourth clutch 4H, 7a is engaged. In the actuated condition of the actuator 7, the rotary member 1 is rotationally fixed relative to the dose display element 10, whereby the rotary member 1 and the dosage indicator member 10 can rotate relative to the housing 4 together. Through the power of the at least one dispensing spring 11; 11a, 11b stored energy to the driving member 8 is 8 causes, due to the threaded engagement of the propulsion member to the rotary member 1, a rotation of the rotary member 1 and the dose indicator element 10 relative to the housing 4, whereby the dose indicator element 10 back screwed to the bearing element 9 in the direction of zero dose position, and wherein the displayed in the PD 14d dose decrements. At the same time the driving member 8 of the at least one dispensing spring 11; 11a, 11b moves relative to the housing 4 in the distal direction to the delivery stroke, which is proportional to the dose previously set. If the dose display element 10 has reached its zero dose position is paid the previously set dose or single dose. Lets the user, the actuator 7 going on, sets the coupling or reset spring 12, the actuator 7, the coupling member 2, the bearing element 9 and the dose indicator 10 back. At reset, the said items will be moved relative to the housing 4 or the dosing member 3 in the proximal direction.

0133When resetting of the device by means of the spring 12, the first clutch 1b, 9e engaged and the second clutch 1b, 2d disengages. The rotary member 1 is once again in a rotationally fixed in relation to the housing 4, wherein the dosing member 3 to the housing 4 and / or the pointing device 4d and / or the rotary member 1 along with the dosage indicator member 10 rotatable relative to a new setting of a product dose or single dose , Resetting Further, the fourth clutch 4H, 7a disengaged and the third clutch 2b, 3c is engaged, whereby the dosing member 3 to the coupling member 2 and the dose indicator 10 is relatively rotatably.

0134Examples Assume after several administrations are still 76 IU contained in the product container 14th With the drive and metering up to 80 IU were adjustable. Since the Dosisbegrenzer is already at 76 IU in contact with the stop means, the dosing member 3 for rotation in the second direction, which would cause an increase in the dose, inhibited. However, the reduction of the dose is made possible by rotating the dosing member 3 in the first rotational direction.

0135By operating the actuator 7, the dose 4d shown in the PD is distributed. Since then, the product container 14 is completely emptied, the drive and metering or injection device is disposed of as a whole. There thus is a single-use injection device. Basically herein shown drive and metering devices but can be applied where a deflated product container 14 is replaced with a new well in conjunction with reusable injection devices.<tables id="tabl0001" num="0001"><table frame="none"><title><b>LIST OF REFERENCE NUMBERS</b></title><tgroup cols="4" colsep="0" rowsep="0"><colspec colnum="1" colname="col1" colwidth="13mm" /><colspec colnum="2" colname="col2" colwidth="75mm" /><colspec colnum="3" colname="col3" colwidth="13mm" /><colspec colnum="4" colname="col4" colwidth="66mm" /><tbody><row><entry>1</entry><entry morerows="1">Rotary member / threaded rod / nut</entry><entry>8d</entry><entry>distal end</entry></row><row><entry>8e</entry><entry>threaded rod</entry></row><row><entry>1a</entry><entry>external thread</entry><entry>8f</entry><entry>slot</entry></row><row><entry>1b</entry><entry>second and / or fourth coupling structure / tooth</entry><entry>8g</entry><entry>Shoulder / ring web</entry></row><row><entry>9</entry><entry>bearing element</entry></row><row><entry>2</entry><entry>Coupling member / display clutch</entry><entry>9a</entry><entry>external thread</entry></row><row><entry>2a</entry><entry>longitudinal guide</entry><entry>9e</entry><entry>first clutch structure / teeth</entry></row><row><entry>2 B</entry><entry>fifth clutch structure</entry><entry>9f</entry><entry>longitudinal guide</entry></row><row><entry>2c</entry><entry>detent member</entry></row><row><entry>2d</entry><entry>third clutch structure</entry><entry>10</entry><entry>Dose indicator / dose indicator barrel</entry></row><row><entry>3</entry><entry>Dosing / dosing / dosage setting</entry><entry>10e</entry><entry>internal thread</entry></row><row><entry>3a</entry><entry>longitudinal guide</entry><entry>11</entry><entry morerows="1">Spring / dispensing spring / compression spring / torsion</entry></row><row><entry>3b</entry><entry>handle structure</entry></row><row><entry>3c</entry><entry>sixth clutch structure</entry><entry>11a</entry><entry>first dispensing spring</entry></row><row><entry>11b</entry><entry>second dispensing spring</entry></row><row><entry>4</entry><entry>housing</entry><entry>11c</entry><entry>intermediate member</entry></row><row><entry>4a</entry><entry>inner sleeve</entry></row><row><entry>4b</entry><entry>outer sleeve</entry><entry>12</entry><entry morerows="1">Spring / reset or clutch spring</entry></row><row><entry>4c</entry><entry>longitudinal guide</entry></row><row><entry>4d</entry><entry>PD / window</entry></row><row><entry>4e</entry><entry>Thread / external thread</entry><entry>14</entry><entry>Product container / carpule</entry></row><row><entry>4g</entry><entry>groove</entry><entry>14a</entry><entry>piston</entry></row><row><entry>4h</entry><entry>seventh coupling structure / internal gear 4i abutment</entry><entry>14b</entry><entry>septum</entry></row><row><entry>15</entry><entry>Klicker</entry></row><row><entry>5</entry><entry>Product container receptacle</entry></row><row><entry>1b, 9e</entry><entry>first clutch</entry></row><row><entry>7</entry><entry>Actuator / actuator button</entry><entry>1b, 2d</entry><entry>second clutch</entry></row><row><entry>7a</entry><entry morerows="1">eighth coupling structure / external toothing</entry><entry>2b, 3c</entry><entry>third clutch</entry></row><row><entry>4h, 7a</entry><entry>fourth clutch</entry></row><row><entry>7b</entry><entry>internal gearing</entry></row><row><entry>8th</entry><entry>Spurring member / follower</entry></row><row><entry>8a</entry><entry>longitudinal rib</entry></row><row><entry>8b</entry><entry>inner sleeve</entry></row><row><entry>8c</entry><entry>/ Female</entry></row></tbody></tgroup></table></tables>