EP1997484A3

Method of identifying GLP-1 secretagogues

Abstract

The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject over that provided by the amount of the GPR119 agonist or the amount of the DPP-FV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-1 level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-1 secretagogues.

EP1997484A3, drawing sheet 1 — Sheet 1 of 1

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Citations
Document	Relation	Office	Category	Cited during	Relevant claims
WO0031258A2	Cites	World Intellectual Property Organization (WIPO)	A	Search report	1-23
WO0050562A2	Cites	World Intellectual Property Organization (WIPO)	A	Search report	1-23
WO0187929A2	Cites	World Intellectual Property Organization (WIPO)	A	Search report	1-23
EP1338651A1	Cites	European Patent Office (EPO)	X	Search report	1-23
EP1538217A1	Cites	European Patent Office (EPO)	PAPX	Search report	1-23
WO2004065380A1	Cites	World Intellectual Property Organization (WIPO)	X	Search report	1-23
WO2004076413A2	Cites	World Intellectual Property Organization (WIPO)	DX	Search report	1-23
WO2005007647A1	Cites	World Intellectual Property Organization (WIPO)	PX	Search report	17-19
WO2006086727A2	Cites	World Intellectual Property Organization (WIPO)	E	Search report	1-23
WO2007120689A2	Cites	World Intellectual Property Organization (WIPO)	E	Search report	1,4-8,17-23
US6468756B1	Cites	United States of America	AX	Search report	1-23
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BRUBAKER P L ET AL: "Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line.", ENDOCRINOLOGY. OCT 1998, vol. 139, no. 10, October 1998 (1998-10-01), pages 4108 - 4114, XP002403176, ISSN: 0013-7227	Non-patent	–	–	Search report	–
DRUCKER DANIEL J: "Enhancing incretin action for the treatment of type 2 diabetes.", DIABETES CARE. OCT 2003, vol. 26, no. 10, October 2003 (2003-10-01), pages 2929 - 2940, XP002386376, ISSN: 0149-5992	Non-patent	–	–	Search report	–
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MAYET S ET AL: "GPR119 activation increases glucose-dependent insulin secretion in insulin-producing cells and isolated rat islets", DIABETOLOGIA, SPRINGER, BERLIN, DE, vol. 48, no. Suppl. 1, 1 September 2005 (2005-09-01), pages A166, XP002449852, ISSN: 0012-186X	Non-patent	–	–	Search report	–
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FYFE MATTHEW ET AL: "Discovery of novel, orally active, synthetic GPR119 agonists as potential agents for treatment of obesity and associated metabolic disorders", DIABETES, AMERICAN DIABETES ASSOCIATION, US, vol. 55, no. suppl. 1, 1 June 2006 (2006-06-01), pages A81, XP009089696, ISSN: 0012-1797	Non-patent	–	–	Search report	–
HIRASAWA AKIRA ET AL: "Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 11, no. 1, 1 January 2005 (2005-01-01), pages 90 - 94, XP002410251, ISSN: 1078-8956	Non-patent	–	–	Search report	–
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129 members in 38 offices

This recordMember, by publication datePriority claim28 more offices are in the list below

Priority claims7

Priority claims
Document	Office	Kind	Date
643086P	United States of America	–	2005-01-10
64308605	United States of America	P	2005-01-10
683172P	United States of America	–	2005-05-19
68317205	United States of America	P	2005-05-19
726880P	United States of America	–	2005-10-14
72688005	United States of America	P	2005-10-14
06717678	European Patent Office (EPO)	A	2006-01-09

Members129

Family members, oldest first
Document	Office	Kind
US2006154866A1	United States of America	A1	2006-07-13
AU2006205164A1	Australia	A1	2006-07-20
CA2593427A1	Canada	A1	2006-07-20
CA2654733A1	Canada	A1	2006-07-20
WO2006076231A2	World Intellectual Property Organization (WIPO)	A2	2006-07-20
DOP2006000008A	Dominican Republic	A	2006-08-31
GT200600004A	Guatemala	A	2006-09-11
WO2006076231A8	World Intellectual Property Organization (WIPO)	A8	2006-09-21
PE20061116A1	Peru	A1	2006-10-12
TW200637534A	Taiwan Province of China	A	2006-11-01
WO2006076231A3	World Intellectual Property Organization (WIPO)	A3	2007-01-18
AR052082A1	Argentina	A1	2007-02-28
EP1758565A2	European Patent Office (EPO)	A2	2007-03-07
US2007072803A1	United States of America	A1	2007-03-29
US2007072804A1	United States of America	A1	2007-03-29
HK1096537A1	Hong Kong, China	A1	2007-06-01
EP1808168A1	European Patent Office (EPO)	A1	2007-07-18
HK1100353A1	Hong Kong, China	A1	2007-09-21
NO20073816L	Norway	L	2007-09-27
NO20101746L	Norway	L	2007-09-27
KR20070095400A	Republic of Korea	A	2007-09-28
IL184364A0	Israel	A0	2007-10-31
MX2007008376A	Mexico	A	2008-01-11
CN101128192A	China	A	2008-02-20
EA200701469A1	Eurasian Patent Organization (EAPO)	A1	2008-02-28
BRPI0606727A	Brazil	A	2008-03-11
NI200700174A	Nicaragua	A	2008-05-09
JP2008110964A	Japan	A	2008-05-15
JP4118323B1	Japan	B1	2008-07-16
JP2008526235A	Japan	A	2008-07-24
ZA200705470B	South Africa	B	2008-07-30
JP2008195733A	Japan	A	2008-08-28
JP2008220374A	Japan	A	2008-09-25
JP2008220375A	Japan	A	2008-09-25
JP2008239623A	Japan	A	2008-10-09
EP1997484A2	European Patent Office (EPO)	A2	2008-12-03
PA8659301A1	Panama	A1	2008-12-18
CN101332303A	China	A	2008-12-31
EP1997484A3This record	European Patent Office (EPO)	A3	2009-02-11
JP4221444B2	Japan	B2	2009-02-12
JP4237243B2	Japan	B2	2009-03-11
EP1758565B1	European Patent Office (EPO)	B1	2009-05-13
AT431139T	Austria	T	2009-05-15
ATE431139T1	Austria	T1	2009-05-15
EP1808168B1	European Patent Office (EPO)	B1	2009-06-03
AT432693T	Austria	T	2009-06-15
ATE432693T1	Austria	T1	2009-06-15
DE602006006765D1	Germany	D1	2009-06-25
EA011883B1	Eurasian Patent Organization (EAPO)	B1	2009-06-30
DE602006007093D1	Germany	D1	2009-07-16
CR9220A	Costa Rica	A	2009-07-31
AU2009202898A1	Australia	A1	2009-08-06
AU2009202900A1	Australia	A1	2009-08-06
PT1758565E	Portugal	E	2009-08-19
PT1808168E	Portugal	E	2009-08-25
HRP20090403T1	Croatia	T1	2009-08-31
DK1758565T3	Denmark	T3	2009-09-07
HRP20090446T1	Croatia	T1	2009-09-30
DK1808168T3	Denmark	T3	2009-10-05
ES2327268T3	Spain	T3	2009-10-27
PL1758565T3	Poland	T3	2009-10-30
SI1758565T1	Slovenia	T1	2009-10-31
SI1808168T1	Slovenia	T1	2009-10-31
ES2327872T3	Spain	T3	2009-11-04
EP2116235A1	European Patent Office (EPO)	A1	2009-11-11
PL1808168T3	Poland	T3	2009-11-30
AU2009202900B2	Australia	B2	2010-02-11
AU2009202898B2	Australia	B2	2010-02-18
SG158876A1	Singapore	A1	2010-02-26
AU2009202900B8	Australia	B8	2010-06-03
US2010137293A1	United States of America	A1	2010-06-03
PE20100398A1	Peru	A1	2010-06-07
KR20100072085A	Republic of Korea	A	2010-06-29
UA91698C2	Ukraine	C2	2010-08-25
US7803753B2	United States of America	B2	2010-09-28
US7803754B2	United States of America	B2	2010-09-28
NZ556219A	New Zealand	A	2010-09-30
CL2010000565A1	Chile	A1	2010-10-15
RS51127B	Serbia	B	2010-10-31
RS51174B	Serbia	B	2010-10-31
US2010285494A1	United States of America	A1	2010-11-11
US2010285495A1	United States of America	A1	2010-11-11
US2010286111A1	United States of America	A1	2010-11-11
US2010286153A1	United States of America	A1	2010-11-11
US2010286168A1	United States of America	A1	2010-11-11
US2010286172A1	United States of America	A1	2010-11-11
US2010291589A1	United States of America	A1	2010-11-18
US2010298333A1	United States of America	A1	2010-11-25
KR20100129328A	Republic of Korea	A	2010-12-08
NZ578502A	New Zealand	A	2011-01-28
NZ587368A	New Zealand	A	2011-01-28
KR101016890B1	Republic of Korea	B1	2011-02-22
NZ578504A	New Zealand	A	2011-02-25
EP2322150A2	European Patent Office (EPO)	A2	2011-05-18
EP2322151A2	European Patent Office (EPO)	A2	2011-05-18
EP2322152A1	European Patent Office (EPO)	A1	2011-05-18
EP2322156A1	European Patent Office (EPO)	A1	2011-05-18
EP2322157A1	European Patent Office (EPO)	A1	2011-05-18
US8003597B2	United States of America	B2	2011-08-23
CA2654733C	Canada	C	2011-09-06

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2009-03-27	Requests to designate patent in hong kongDE	DE	HK
2009-03-04	First examination report despatched17Q	17Q	EP
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Method of identifying GLP-1 secretagogues

Abstract

Term

Priority claims7

Members129

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Titles3

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Designated states36