Nova Patents
EP1518864A3

Antibody against rhesus D

Abstract

The present invention relates to a monoclonal antibody having at its glycosylation site (Asn 297) of Fcγ glycan structures of the biantennary type, with short chains, low sialylation, mannoses and GIcNAc of the non-intermediate terminal attachment point and a rate of less than 65% fucose.

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Projected expiry passed 12 April 2021, 5.5 years ago.

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Citations
DocumentRelationOfficeCategoryCited duringRelevant claims
WO9954342A1CitesWorld Intellectual Property Organization (WIPO)XSearch report1-10
WRIGHT A ET AL: "Effect of glycosylation on antibody function: implications for genetic engineering", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 15, no. 1, 1 January 1997 (1997-01-01), pages 26 - 32, XP004016809, ISSN: 0167-7799Non-patentSearch report
KLEIN PHILIPPE ET AL: "Human recombinant anti-Rh(D) monoclonal antibodies: Improvement of biological properties by in vitro class-switch.", HUMAN ANTIBODIES, vol. 8, no. 1, 1997, pages 17 - 25, XP001015726, ISSN: 1093-2607Non-patentSearch report
HADLEY, A. G. ET AL: "The functional activity of Fc.gamma.RII and Fc.gamma.RIII on subsets of human lymphocytes", IMMUNOLOGY, vol. 76, no. 3, 1992, pages 446 - 451, XP001015733Non-patentSearch report
PATERSON T ET AL: "Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies", IMMUNOTECHNOLOGY,NL,ELSEVIER SCIENCE PUBLISHERS BV, vol. 4, no. 1, 1 June 1998 (1998-06-01), pages 37 - 47, XP004127385, ISSN: 1380-2933Non-patentSearch report