Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
Abstract
The present invention provides a pharmaceutically acceptable salt of a compound of formula (I) wherein R1 is, among other things, a C2-C4 alkenyl group, R2 is, among others, hydrogen, R3 and R4 are, independently of one another, hydrogen, R5 is, among other things, hydrogen, R6 is, among others, hydrogen, R9 is, among others, hydrogen, R10 and R11 are, independently of one another, hydrogen, hydroxy and halo. The present invention also provides pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier, and the use of the present invention for the preparation of a medicament for the preparation of a RNA-dependent RNA virus polymerase inhibitor or for inhibiting RNA-dependent RNA virus replication. HE
Term
Term ended
Expired 18 January 2022, 4.7 years ago.
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89 members in 36 offices
Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 26331301 | United States of America | P | |
| 28206901 | United States of America | P | |
| 29932001 | United States of America | P | |
| 34452801 | United States of America | P |
Members89
| Document | Office | Kind | |
|---|---|---|---|
| CA2433878A1 | Canada | A1 | |
| WO02057287A2 | World Intellectual Property Organization (WIPO) | A2 | |
| WO02057425A2 | World Intellectual Property Organization (WIPO) | A2 | |
| CA2434386A1 | Canada | A1 | |
| US2002147160A1 | United States of America | A1 | |
| WO02057287A3 | World Intellectual Property Organization (WIPO) | A3 | |
| IS6860A | Iceland | A | |
| NO20033289D0 | Norway | D0 | |
| NO20033289L | Norway | L | |
| EE200300338A | Estonia | A | |
| EP1355916A2 | European Patent Office (EPO) | A2 | |
| SK9322003A3 | Slovakia | A3 | |
| IL156641A0 | Israel | A0 | |
| KR20040002854A | Republic of Korea | A | |
| BR0206614A | Brazil | A | |
| US2004067901A1 | United States of America | A1 | |
| CZ20032005A3 | Czechia | A3 | |
| US2004072788A1 | United States of America | A1 | |
| EA200300819A1 | Eurasian Patent Organization (EAPO) | A1 | |
| CN1498221A | China | A | |
| US2004110717A1 | United States of America | A1 | |
| HU0400726A2 | Hungary | A2 | |
| HUP0400726A2 | Hungary | A2 | |
| AR035736A1 | Argentina | A1 | |
| JP2004520367A | Japan | A | |
| ZA200305078B | South Africa | B | |
| US6777395B2 | United States of America | B2 | |
| BG108000A | Bulgaria | A | |
| JP2004532184A | Japan | A | |
| PL363216A1 | Poland | A1 | |
| MXPA03006514A | Mexico | A | |
| NZ526703A | New Zealand | A | |
| HK1066014A | Hong Kong, China | A | |
| HK1066014A1 | Hong Kong, China | A1 | |
| WO02057425A3 | World Intellectual Property Organization (WIPO) | A3 | |
| EP1539188A2 | European Patent Office (EPO) | A2 | |
| HRP20030565A2 | Croatia | A2 | |
| GEP20053601B | Georgia | B | |
| UA73843C2 | Ukraine | C2 | |
| US2005272676A1 | United States of America | A1 | |
| AU2002243791B2 | Australia | B2 | |
| CN1267446C | China | C | |
| TWI261056B | Taiwan Province of China | B | |
| US7105499B2 | United States of America | B2 | |
| US2006205686A1 | United States of America | A1 | |
| AU2002243600B2 | Australia | B2 | |
| EP1707571A1 | European Patent Office (EPO) | A1 | |
| US7125855B2 | United States of America | B2 | |
| EA007491B1 | Eurasian Patent Organization (EAPO) | B1 | |
| US2006264390A1 | United States of America | A1 | |
| CA2434386C | Canada | C | |
| EP1355916B1 | European Patent Office (EPO) | B1 | |
| DE60217465D1 | Germany | D1 | |
| US7202224B2 | United States of America | B2 | |
| PT1355916E | Portugal | E | |
| SI1355916T1 | Slovenia | T1 | |
| DK1355916T3 | Denmark | T3 | |
| JP3914156B2 | Japan | B2 | |
| HU0400726A3 | Hungary | A3 | |
| HUP0400726A3 | Hungary | A3 | |
| ES2278009T3 | Spain | T3 | |
| JP2007224045A | Japan | A | |
| DE60217465T2 | Germany | T2 | |
| US2007275912A1 | United States of America | A1 | |
| MY134070A | Malaysia | A | |
| KR100828453B1 | Republic of Korea | B1 | |
| IS2449B | Iceland | B | |
| CA2433878C | Canada | C | |
| NO326431B1 | Norway | B1 | |
| SK286630B6 | Slovakia | B6 | |
| RS50236B | Serbia | B | |
| EP1539188A4 | European Patent Office (EPO) | A4 | |
| PL207405B1 | Poland | B1 | |
| EP2360166A1 | European Patent Office (EPO) | A1 | |
| EP1707571B1 | European Patent Office (EPO) | B1 | |
| AT526339TThis record | Austria | T | |
| ATE526339T1 | Austria | T1 | |
| EP2399588A1 | European Patent Office (EPO) | A1 | |
| HRP20030565B1 | Croatia | B1 | |
| BG66207B1 | Bulgaria | B1 | |
| JP4931683B2 | Japan | B2 | |
| US2012165515A1 | United States of America | A1 | |
| US8481712B2 | United States of America | B2 | |
| EE05709B1 | Estonia | B1 | |
| US2014309412A1 | United States of America | A1 | |
| EP1539188B1 | European Patent Office (EPO) | B1 | |
| ES2532836T3 | Spain | T3 | |
| US2017183373A1 | United States of America | A1 | |
| EP2399588B1 | European Patent Office (EPO) | B1 |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Ceased as to paragraph 5 lit. 3 law introducing patent treatiesCeasedRER | RER |
Numbers
- Application
- 6076021
Titles2
- German
- NUKLEOSIDDERIVATE ALS INHIBITOREN DER RNA- ABHÄNGIGEN VIRALEN RNA-POLYMERASE
- English
- NUCLEOSIDE DERIVATIVES AS INHIBITORS OF THE RNA-DEPENDENT VIRAL RNA POLYMERASE
Classification
- CPC, 20
- C07H19/14
- C07H19/16
- A61K9/4858
- A61K31/7056
- A61K31/7064
- A61K31/7076
- A61K38/21
- A61K45/06
- A61P1/16
- A61P31/00
- A61P31/14
- A61P43/00
- C07D473/00
- C07D487/04
- C07H19/00
- C07H19/06
- C07H19/10
- C07H19/12
- C07H19/20
- Y02P20/582
- IPC, 34
- C07D487 04
- C07H19 14
- A61K31 519
- A61K31 70
- A61K31 7052
- A61K31 706
- A61K31 7064
- A61K31 7068
- A61K31 7076
- A61K31 708
- A61K31 7105
- A61K31 712
- A61K38 21
- A61K45 00
- A61K45 06
- A61P1 16
- A61P31 14
- A61P43 00
- C07D473 00
- C07D487 02
- C07H
- C07H19 00
- C07H19 04
- C07H19 048
- C07H19 06
- C07H19 067
- C07H19 09
- C07H19 10
- C07H19 16
- C07H19 167
- C07H19 173
- C07H19 19
- C07H19 20
- C12N