WO2016164609A3
Production of oversized adeno-associated vectors
Abstract
Provided herein are methods for producing an adeno-associated virus (AAV) particle containing an oversized recombinant AAV genome (e.g., greater than 4.7 kb). In some aspects, the invention provides AAV particles and AAV vectors comprising oversized rAAV genomes. Producer cell lines to produce AAV particles comprising oversized genomes are also provided.
Term
No projected expiry on record.
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Every citation, both ways
| Document | Relation | Office | Category | Cited during | Relevant claims |
|---|---|---|---|---|---|
| WO0127303A1 | Cites | World Intellectual Property Organization (WIPO) | A | International search | 1-174 |
| US2004092008A1 | Cites | United States of America | A | International search | 1-174 |
| US2007042462A1 | Cites | United States of America | A | International search | 1-174 |
| WO2014064277A1 | Cites | World Intellectual Property Organization (WIPO) | X | International search | 36,106,109-119,121,123-126,129,132,133,135-147,149,151-154,157,168,169 |
| WO2015038625A1 | Cites | World Intellectual Property Organization (WIPO) | XI | International search | 36,136-145,149-156,168,169,174 |
| ZHENHUA YUAN ET AL: "A Versatile Adeno-Associated Virus Vector Producer Cell Line Method for Scalable Vector Production of Different Serotypes", HUMAN GENE THERAPY, vol. 22, no. 5, 1 May 2011 (2011-05-01), US, pages 613 - 624, XP055312398, ISSN: 1043-0342, DOI: 10.1089/hum.2010.241 | Non-patent | – | – | International search | – |
| R. SARKAR: "Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype", BLOOD, vol. 103, no. 4, 23 October 2003 (2003-10-23), US, pages 1253 - 1260, XP055312225, ISSN: 0006-4971, DOI: 10.1182/blood-2003-08-2954 | Non-patent | – | – | International search | – |
| HUI LU ET AL: "Complete Correction of Hemophilia A with Adeno-Associated Viral Vectors Containing a Full-Size Expression Cassette", HUMAN GENE THERAPY, vol. 19, no. 6, 1 June 2008 (2008-06-01), US, pages 648 - 654, XP055311436, ISSN: 1043-0342, DOI: 10.1089/hum.2007.0182 | Non-patent | – | – | International search | – |
| ZHIJIAN WU ET AL: "Effect of Genome Size on AAV Vector Packaging", MOLECULAR THERAPY, vol. 18, no. 1, 1 January 2010 (2010-01-01), GB, pages 80 - 86, XP055235504, ISSN: 1525-0016, DOI: 10.1038/mt.2009.255 | Non-patent | – | – | International search | – |
| WILLIAM E. GROSE ET AL: "Homologous Recombination Mediates Functional Recovery of Dysferlin Deficiency following AAV5 Gene Transfer", PLOS ONE, vol. 7, no. 6, 15 June 2012 (2012-06-15), pages e39233, XP055074203, DOI: 10.1371/journal.pone.0039233 | Non-patent | – | – | International search | – |
| ZIYING YAN ET AL: "Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers", HUMAN GENE THERAPY, vol. 26, no. 6, 11 March 2015 (2015-03-11), US, pages 334 - 346, XP055308423, ISSN: 1043-0342, DOI: 10.1089/hum.2015.001 | Non-patent | – | – | International search | – |
| JOHN MARTIN ET AL: "Generation and Characterization of Adeno-Associated Virus Producer Cell Lines for Research and Preclinical Vector Production", HUMAN GENE THERAPY METHODS, vol. 24, no. 4, 1 August 2013 (2013-08-01), pages 253 - 269, XP055312388, ISSN: 1946-6536, DOI: 10.1089/hgtb.2013.046 | Non-patent | – | – | International search | – |
| SIRKKA KYOSTIO-MOORE ET AL: "The impact of minimally oversized adeno-associated viral vectors encoding human factor VIII on vector potency in vivo", MOLECULAR THERAPY - METHODS & CLINICAL DEVELOPMENT, vol. 3, 1 January 2016 (2016-01-01), pages 16006, XP055311906, DOI: 10.1038/mtm.2016.6 | Non-patent | – | – | International search | – |
| NAMBIAR BINDU ET AL: "Evaluation of Producer Cell Line Platform for Production of Oversized AAV-FVIII Vectors", MOLECULAR THERAPY, vol. 24, no. Suppl. 1, May 2016 (2016-05-01), & 19TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-GENE-AND-CELL-THERAPY (ASGCT); WASHINGTON, DC, USA; MAY 04 -07, 2016, pages S40, XP002763219 | Non-patent | – | – | International search | – |
63 members in 31 offices; this record represents the family
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| CA2982123A1 | Canada | A1 | |
| WO2016164609A2 | World Intellectual Property Organization (WIPO) | A2 | |
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| WO2016164609A3This record | World Intellectual Property Organization (WIPO) | A3 | |
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| TWI707951B | Taiwan Province of China | B | |
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| PL3280799T3 | Poland | T3 | |
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| KR102848324B1 | Republic of Korea | B1 | |
| KR20250126875A | Republic of Korea | A |
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| Wipo information: withdrawn in national officeWithdrawnWWW | WWW | WO | |
| Wipo information: published in national officeWWP | WWP | WO | |
| Wipo information: divisional of initial pct applicationWWD | WWD | WO | |
| Entry into the national phaseENP | ENP | BR | |
| Ep: the epo has been informed by wipo that ep was designated in this application121 | 121 | WO | |
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| Pct publication - request for entry into the national phase [chapter 1.1 patent gazette]B01A | B01A | BR | |
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Numbers
- Publication
- 2016/164609
- Application
- 26486
Titles2
- English
- PRODUCTION OF OVERSIZED ADENO-ASSOCIATED VECTORS
- French
- PRODUCTION DE VECTEURS ADÉNO-ASSOCIÉS SURDIMENSIONNÉS
Classification
- CPC, 9
- C12N7/00
- C12N15/86
- C07K14/755
- C12N2750/14152
- C12N2750/14143
- A61P21/00
- A61P11/00
- A61K38/1709
- C12N2710/10041
- IPC, 4
- C12N7 00
- A61K48 00
- C12N5 10
- C12N15 864
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