WO2005123780A3
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
Abstract
The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and/or the serum half-life in comparison to the unmodified antibody.
Term
No projected expiry on record.
- Priority
- Filed
- Published
- Today
Every citation, both ways
| Document | Relation | Office | Cited during |
|---|---|---|---|
| US2002142000A1 | Cites | United States of America | International search |
| US6197297B1 | Cites | United States of America | International search |
| US6388487B1 | Cites | United States of America | International search |
| US7163681B2 | Cites | United States of America | International search |
62 members in 18 offices
Priority claims6
| Document | Office | Kind | Date |
|---|---|---|---|
| 2004011213 | United States of America | W | |
| 82230004 | United States of America | A | |
| 10822300 | – | – | – |
| PCTUS2004011213 | – | – | – |
| US20040822300 | – | – | – |
| WO2004US11213 | – | – | – |
Members62
| Document | Office | Kind | |
|---|---|---|---|
| CA2502904A1 | Canada | A1 | |
| WO2004035752A2 | World Intellectual Property Organization (WIPO) | A2 | |
| AU2003286467A1 | Australia | A1 | |
| AU2004231078A1 | Australia | A1 | |
| CA2522331A1 | Canada | A1 | |
| WO2004092219A2 | World Intellectual Property Organization (WIPO) | A2 | |
| US2005014934A1 | United States of America | A1 | |
| US2005032114A1 | United States of America | A1 | |
| WO2004092219A3 | World Intellectual Property Organization (WIPO) | A3 | |
| CA2545539A1 | Canada | A1 | |
| WO2005037867A1 | World Intellectual Property Organization (WIPO) | A1 | |
| WO2004035752A3 | World Intellectual Property Organization (WIPO) | A3 | |
| WO2005037867B1 | World Intellectual Property Organization (WIPO) | B1 | |
| EP1562972A2 | European Patent Office (EPO) | A2 | |
| US2005226864A1 | United States of America | A1 | |
| US2005276799A1 | United States of America | A1 | |
| WO2005123780A2 | World Intellectual Property Organization (WIPO) | A2 | |
| EP1615955A2 | European Patent Office (EPO) | A2 | |
| KR20060022231A | Republic of Korea | A | |
| BRPI0409269A | Brazil | A | |
| JP2006512087A | Japan | A | |
| MXPA05010902A | Mexico | A | |
| EP1562972A4 | European Patent Office (EPO) | A4 | |
| EP1673395A1 | European Patent Office (EPO) | A1 | |
| CN1798767A | China | A | |
| US7217797B2 | United States of America | B2 | |
| US7217798B2 | United States of America | B2 | |
| JP2007525171A | Japan | A | |
| JP2007531707A | Japan | A | |
| WO2005123780A3This record | World Intellectual Property Organization (WIPO) | A3 | |
| US7361740B2 | United States of America | B2 | |
| US7365168B2 | United States of America | B2 | |
| US2008287657A1 | United States of America | A1 | |
| AU2003286467B2 | Australia | B2 | |
| US7732570B2 | United States of America | B2 | |
| EP1562972B1 | European Patent Office (EPO) | B1 | |
| AT480562T | Austria | T | |
| ATE480562T1 | Austria | T1 | |
| DE60334141D1 | Germany | D1 | |
| PT1562972E | Portugal | E | |
| DK1562972T3 | Denmark | T3 | |
| SI1562972T1 | Slovenia | T1 | |
| ES2350202T3 | Spain | T3 | |
| CN1798767B | China | B | |
| JP2011052012A | Japan | A | |
| JP4685764B2 | Japan | B2 | |
| AU2004231078B2 | Australia | B2 | |
| US2011183412A1 | United States of America | A1 | |
| JP4768439B2 | Japan | B2 | |
| KR101157845B1 | Republic of Korea | B1 | |
| EP1615955B1 | European Patent Office (EPO) | B1 | |
| DK1615955T3 | Denmark | T3 | |
| PT1615955E | Portugal | E | |
| ES2394088T3 | Spain | T3 | |
| SI1615955T1 | Slovenia | T1 | |
| ES2394088T8 | Spain | T8 | |
| PL1615955T3 | Poland | T3 | |
| CA2502904C | Canada | C | |
| CA2522331C | Canada | C | |
| US8624007B2 | United States of America | B2 | |
| CY1110877T1 | Cyprus | T1 | |
| CY1113400T1 | Cyprus | T1 |
6 legal events, as 2 offices reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | Office | |
|---|---|---|---|
| Ep: pct application non-entry in european phase122 | 122 | WO | |
| Non-entry into the national phaseNENP | NENP | DE | |
| Wipo information: withdrawn in national officeWithdrawnWWW | WWW | WO | |
| Ep: the epo has been informed by wipo that ep was designated in this application121 | 121 | WO | |
| Designated statesAK | AK | WO | |
| Designated countries for regional patentsAL | AL | WO |
Numbers
- Publication
- 2005/123780
- Publication, DOCDB
- 2005123780
- Publication, EPODOC
- WO2005123780
- Application
- 11996
- Application, DOCDB
- 2005011996
- Application, EPODOC
- WO2005US11996
Titles2
- English
- ALTERATION OF FCRN BINDING AFFINITIES OR SERUM HALF-LIVES OF ANTIBODIES BY MUTAGENESIS
- French
- MODIFICATION DES AFFINITES DE LIAISON POUR LE FCRN OU DE LA DEMI-VIE SERIQUE D'ANTICORPS PAR MUTAGENESE
Classification
- CPC, 9
- C07K16/00
- C07K16/249
- C07K16/2809
- C07K16/2833
- C07K16/2866
- C07K2317/21
- C07K2317/34
- C07K2317/52
- C07K2317/732
- IPC, 5
- A61K39 395
- C07K16 00
- C07K16 24
- C07K16 28
- C07K16 44
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