Azaindole derivatives, use thereof and pharmaceutical composition containing the same
11 claims: 1 independent, 10 dependent
- 1PATENTOVÉ NÁROKY sa t ý m, 1. Farmaceutická kompozícia, vyzná že obsahuje účinné množstvo selektívneho ΡΡ čuj ú c a inhibítora kinázy, ktorým je zlúčenina všeobecného vzorca I (I) kde R 1 je arylová skupina alebo heteroarylová skupina každá prípadne substituovaná jednou alebo niekoľkými skupinami vybranými zo skupiny, ktorú tvorí acylová skupina, alkyléndioxyskupina, alkenylová skupina, alkenyloxyskupina, alkinylová skupina, arylová skupina, kyanoskupina, atóm halogénu, hydroxylová skupina, heteroarylová skupina, heterocykloalkylová skupina, nitroskupina, skupina R 4 , skupina -C(=0)-NY 1 Y 2 , skupina -C(=O)-OR 5 , skupina -ΝΥ Χ Υ 2 , skupina -N (R 6 )-C (=0)-R 7 , skupina -N (R 6 )-C (=0)-NY 3 Y 4 , skupina -N (R 6 )-C (=0)-OR 7 , skupina -N (R 6 )-SO2-R 7 , skupina -N (R 6 )-SO2-NY 3 Y 4 , skupina -SO 2 -NY 1 Y 2 a skupina -Z 2 R 4 ;R 2 je atóm vodíka, acylová skupina, kyanoskupina, atóm halogénu, nižšia alkenylová skupina alebo nižšia alkylová skupina prípadne substituovaná substituentom vybraným zo skupiny, ktorú tvorí kyanoskupina, heteroarylová skupina, heterocykloalkylová skupina, skupina -Z^ 8 , skupina -C (=0)-NY 3 Y 4 , skupina -CO2R 8 , skupina -NY 3 Y 4 , skupina -N (R 6 )-C (=0)-R 7 , skupina -N (R 6 )-C (=0)-NY 3 Y 4 , skupina -N (R 6 )-C (=0)-OR 7 , skupina -N (R 6 ) — S02—R 7 , skupina -N (R 6 )-SO 2 -NY 3 Y 4 a jeden alebo niekoľko atómov halogénu;298 R 3 je atóm vodíka, arylová skupina, kyanoskupina, atóm halogénu, heteroarylová skupina, nižšia alkylová skupina, skupina -C(=O)-OR 5 alebo skupina -C(=O)-NY 3 Y;R 4 je alkylová skupina, cykloalkylová skupina alebo cykloalkylalkylová skupina každá prípadne substituovaná substituentom vybraným zo skupiny, ktorú tvorí arylová skupina, cykloalkylová skupina, kyanoskupina, heterocykloalkylová 6- alebo 7-členný -C (=0)-NY 3 Y 2 , skupina -N (R 6 ) -C (=0) -R 7 , — 7 atóm halogénu, heteroarylová skupina, jej 5-, skupina skupina, skupina -CHO (alebo skupina -N (R 6 )-SO2-R 7 , skupina -N (R 6 )-SO2-NY 3 Y 4 , alebo niekoľko skupín vybraných hydroxylová skupina a karboxylová cyklický acetálový derivát), -C(=O)-OR 5 , skupina -NY^ 2 , skupina -N (R 6 )-C (=0)-NY 3 Y 4 , skupina skupina -OR 7 a jedna zo skupiny, ktorú tvorí skupina;R 5 je atóm vodíka, alkylová skupina, alkenylová skupina, arylová skupina, arylalkylová skupina, heteroarylová skupina alebo heteroarylalkylová skupina;R 6 je atóm vodíka alebo nižšia alkylová skupina;R 7 je alkylová skupina, arylová skupina, arylalkylová skupina, cykloalkylová skupina, cykloalkylalkylová skupina, heteroarylová skupina, heteroarylalkylová skupina, heterocykloalkylová skupina alebo heterocykloalkylalkylová skupina;R 8 je atóm vodíka alebo nižšia alkylová skupina;X 1 je atóm dusíka, skupina CH, skupina C-halogén, skupina C-CN, skupina C-R 7 , skupina C-NY 3 Y 4 , skupina C-OH, skupina C-Z 2 R 7 , skupina C-C(=0)-0R 5 , skupina C-C (=0)-NY 3 Y 4 , skupina C-N(R 8 )-C(=0)-R 7 , skupina C-SO2-NY 3 Y 4 , skupina C-N (R 8 )-SO2-R 7 , C-alkenylová skupina, C-alkinylová skupina alebo skupina C-NO 2 ;Y 1 a Y 2 sú nezávisle od seba atóm vodíka, alkenylová skupina, arylová skupina, cykloalkylová skupina, heteroarylová sku pina alebo alkylová skupina prípadne substituovaná jednou 299 alebo niekoľkými skupinami vybranými zo skupiny, ktorú tvorí arylová skupina, atóm halogénu, heteroarylová skupina, hydroxylová skupina, skupina -C (=0)-NY 3 Y 4 , skupina -C(=O)-OR 5 , skupina -NY 3 Y 4 , skupina -N (R 6 )-C (=0)-R 7 , skupina -N(R 6 )-C (=0)-NY 3 Y 4 , skupina -N (R 6 )-SO2-R 7 , skupina -N (R 6 )-SO2-NY 3 Y 4 a skupina -OR ;alebo môže skupina -NY Y tvoriť cyklický amín;Y 3 a Y 4 sú nezávisle od seba atóm vodíka, alkenylová skupina, alkylová skupina, arylová skupina, arylalkylová skupina, cykloalkylová skupina, heteroarylová skupina alebo heteroarylalkylová skupina;alebo môže skupina -NY 3 Y 4 tvoriť cyklický amín;Z 1 je atóm kyslíka alebo atóm síry;Z 2 je atóm kyslíka alebo skupina S(0) n ;n je 0 alebo celé číslo 1 alebo 2;s podmienkou, že ak R 1 je substituovaná arylová skupina, R 2 je nižšia alkylová skupina substituovaná skupinou -C(=0)-NY 3 Y 4 , -N (R 6 )-C (=0)-R 7 alebo -N (R 6 )-C (=0)-NY 3 Y 4 a R 3 je atóm vodíka, atóm halogénu alebo nižšia alkylová skupina, potom X 1 je iné než skupina CH;a jej zodpovedajúce N-oxidy, jej proliečivá, jej kyselinové bioizostéry;a farmaceutický prijateľné soli a solváty, napríklad hydráty, týchto zlúčenín a ich N-oxidy a ich proliečivá a ich kyselinové bioizostéry;spolu s jedným alebo niekoľkými farmaceutický prijateľnými nosičmi alebo vehikulami.
- 2Zlúčeniny všeobecného vzorce I podľa nároku 1, okrem nasledovných zlúčenín:2-fenyl-lH-pyrolo[2,3-b]pyridín, 2-(4-brómfenyl)-3-metyl-lH-pyrolo[2,3-b]pyridín, 300 metylester kyseliny 4-(3-metyl-lH-pyrolo[2,3-b]pyridin-2-yl)benzoovej, 2-(4-chlórfenyl)-lH-pyrolo[2,3-b]pyridín, 2-(4-metoxyfenyl)-IH-pyrolo[2,3-b]pyridín, 5- metyl-2-fenyl-lH-pyrolo[2,3-b]pyridín, 4-metyl-2-fenyl-lH-pyrolo[2,3-b]pyridín, 2-(pyrid-3-yl)-lff-pyrolo[2,3-b]pyridín, kyselina 4-(3-metyl-ltt-pyrolo[2,3-b]pyrid-2-yl)benzoová, 2-(4-metoxyfenyl)-3-metyl-lH-pyrolo[2,3-b]pyridín, 2-(4-metylfenyl)-3-metyl-lH-pyrolo[2,3-b]pyridín, izopropylester kyseliny 4-(3-metyl-lH-pyrolo[2,3-b]pyrid-2-yl)benzoovej kyseliny, 2- f enyl-3-metyl-l/í-pyrolo [2,3-b] pyridín, 6- fenyl-5H-pyrolo[2,3-b]pyrazín, 6-(4-metoxyfenyl)-5H-pyrolo[2,3-b]pyrazín, 6-(4-chlórfenyl)-5H-pyrolo[2,3-b]pyrazín, 6- (2-chlórfenyl)-5H-pyrolo[2,3-b]pyrazín,
- 33- metyl-6-fenyl-5H-pyrolo ['2, 3-b] pyrazín, 2-metyl-6-fenyl-5fí-pyrolo[2,3-b]pyrazín, a 7- metyl-6-fenyl-5H-pyrolo[2,3-b]pyrazín. 3. Zlúčenina podľa nároku 2, kde R 1 je prípadne substituovaná heteroarylová skupina.
- 4Zlúčenina podľa nároku 3, kde R 1 je prípadne substituovaná 301 azaheteroarylová skupina.
- 5Zlúčenina podľa nároku 2, kde R 1 je prípadne substituovaná indolylová skupina, prípadne substituovaná furylová skupina, prípadne substituovaná pyridylová skupina, prípadne substituovaná pyrolylová skupina, prípadne substituovaná pyrazolylová skupina, prípadne substituovaná chinolylová skupina, prípadne substituovaná izochinolylová skupina, prípadne substituovaná imidazolylová skupina, prípadne substituovaná indazolylová skupina, prípadne substituovaná indolizinylová skupina, prípadne substituovaná tetrahydroindolizinylová skupina alebo prípadne substituovaná indazolinylová skupina.
- 6Zlúčenina podľa ktoréhokoľvek z nárokov 3 až 5, kde prípadnými substituentami v rámci skupiny R 1 sú jedna alebo viac skupín vybraných zo skupiny, ktorú tvorí alkyléndioxyskupina, alkenylová skupina, alkenyloxyskupina, arylová skupina, karboxylová skupina alebo kyselinový bioizostér, kyanoskupina, atóm halogénu, hydroxylová skupina, heteroarylová skupina, heterocykloalkylová skupina, skupina R 4 , skupina -C(=O)-R 4 , skupina -C (=0)-ΝΥ Χ Υ 2 , skupina -C(=O)-OR 5 , skupina -ΝΥ Χ Υ 2 a skupina -OR 4 .
- 7Zlúčenina podľa nároku 2, kde R 1 je prípadne substituovaná arylová skupina.
- 8Zlúčenina podľa nároku 7, kde R 1 je fenylová skupina substituovaná jednou alebo viacerými skupinami vybranými zo skupiny, ktorú tvorí alkyléndioxyskupina, atóm halogénu, skupina R 4 , skupina -NY X Y 2 a skupina -OR 4 .
- 9Zlúčenina podľa ktoréhokoľvek z nárokov 2 až 8, kde R 2 je atóm vodíka.
- 10Zlúčenina podľa ktoréhokoľvek z nárokov 2 až 8, kde R 2 je 302 atóm halogénu.
- 11Zlúčenina podlá ktoréhokoľvek z nárokov 2 až 8, kde R 2 je nižšia alkylová skupina pripadne substituovaná karboxylovou skupinou, kyanoskupinou, atómom halogénu, hydroxylovou skupinou, tetrazolylovou skupinou alebo skupinou -CONY 3 Y 4 . prípadne substituovaná arylová skupina. nižšia alkylová skupina. 17. Zlúčenina podľa ktoréhokoľvek nárokov až 16, kde X 1 je atóm dusíka. 18. Zlúčenina podľa ktoréhokoľvek nárokov až 16, kde X 1 je skupina CH. 19. Zlúčenina podľa ktoréhokoľvek nárokov až 16, kde X 1 je C-nižšia alkoxyskupina. C-arylová skupina. 20. Zlúčenina podľa ktoréhokoľvek z nárokov až 16, kde X 1 je 303 21. Zlúčenina podlá ktoréhokolvek z nárokov 2 až 16, kde X 1 je skupina C-Cl. 22. Zlúčenina podľa ktoréhokoľvek z nárokov 2 až 16, kde X 1 je skupina C-CN. 23. Zlúčenina všeobecného vzorce ľa (ľa) kde R 2 , R 3 a X 1 sú definované ako v nároku 1; R 9 je atóm vodíka, skupina R 4 , alkenylová skupina alebo heterocykloalkylová skupina; R 10 je alkenyloxyskupina, karboxylová skupina alebo kyselinový bioizostér, kyanoskupina, atóm halogénu, hydroxylová skupina, heteroarylová skupina, skupina R 4 , skupina -C(=O)-R 4 , skupina -C (=0)-NY 1 Y 2 , skupina -OR 4 , skupina -N (R 6 )-C (=0)-R 7 , skupina -N (R 6 )-SO 2 -R 7 alebo skupina -NY X Y 2 ; a p je 0 alebo celé číslo 1 alebo 2; a jej proliečivá a farmaceutický prijateľné soli a solváty, na príklad hydráty, zlúčenín všeobecného vzorca la a ich proliečiv; 24. Zlúčenina podľa nároku 23, kde R 2 je atóm vodíka. 25. Zlúčenina podľa nároku 23 alebo 24, kde R 3 je atóm vodíka, prípadne substituovaná arylová skupina alebo nižšia alkylová 304 skupina. 26. Zlúčenina podía ktoréhokoľvek z nárokov 23 až 25, kde X 1 je skupina CH, C-nižšia alkoxyskupina, C-arylová skupina, C-atóm halogénu, skupina C-CN alebo atóm dusíka. 27. Zlúčenina podľa ktoréhokoľvek z nárokov 23 až 26, kde R 9 je:(i) atóm vodíka;(ii) alkylová skupina obsahujúca 1 až 4 atómy uhlíka;(vi) cykloalkylalkylová skupina substituovaná hydroxylovou skupinou . 28. Zlúčenina podľa ktoréhokoľvek z nárokov 23 až 27, kde R 10 je: (i) hydroxylová skupina;(ii) skupina -OR 4 , kde R 4 je alkylová skupina;(iii) skupina -OR 4 , kde R 4 je alkylová skupina alebo cykloalkylalkylová skupina, každá z týchto skupín je substituovaná jednou alebo niekoľkými hydroxylovými skupinami;(iv) skupina -OR 4 , kde R 4 je alkylová skupina substituovaná jednou alebo niekoľkými alkoxyskupinami;(v) skupina -OR 4 , kde R 4 je alkylová skupina alebo cykloalkýlová 305 skupina, každá z týchto skupín je substituovaná jednou alebo niekoľkými karboxylovými skupinami;(vi) skupina -OR 4 , kde R 4 je cykloalkylová skupina substituovaná skupinou -C(=0)-NY 3 Y 2 ;(vii) skupina -N (R 6 )-C (=0)-R 7 ;(viii) skupina -CONY^ 2 ;(ix) karboxylová skupina;(x) alkylová skupina substituovaná karboxylovou skupinou;(xi) heteroarylová skupina;(xii) skupina -C(=0)-R 4 , kde R 4 je alkylová skupina;alebo (xiii) tetrazolylová skupina alebo N-metyltetrazolylová skupina. 29. Zlúčenina podľa nároku 28, kde R 10 je viazaná v polohe 5 indolylového kruhu. 30. Zlúčenina všeobecného vzorca Ib (Ib) kde R 2 , R 3 , R 9 , R 10 , X 1 a p sú definované ako v nároku 23, a jej proliečivá a farmaceutický prijateľné .soli a solváty, napríklad hydráty, zlúčenín všeobecného vzorca Ib a ich proliečiv. 31. Zlúčenina podľa nároku 30, kde R 2 je atóm vodíka. 306 32. Zlúčenina podía nároku 30 alebo 31, kde R 3 je atóm vodíka, prípadne substituovaná arylová skupina alebo nižšia alkylová skupina. 33. Zlúčenina podía ktoréhokoľvek z nárokov 30 až 32, kde X 1 je skupina CH, C-nižšia alkoxyskupina, C-arylová skupina, skupina C-halogén, skupina C-CN alebo atóm dusíka. 34. Zlúčenina podľa ktoréhokoľvek z nárokov 30 až 33, kde R 9 je atóm vodíka alebo alkylová skupina obsahujúca 1 až 4 atómy uhlíka. 35. Zlúčenina podľa ktoréhokoľvek z nárokov 30 až 34, kde p je 36. Zlúčenina všeobecného vzorca Ic (Ic) kde R 2 , R 3 , R 9 , R 10 , X 1 a p sú definované ako v nároku 23, a jej proliečivá a farmaceutický prijateľné soli a solváty, napríklad hydráty, zlúčenín všeobecného vzorca Ic a ich prol'iečiv. 37. Zlúčenina podľa nároku 36, kde R 2 je atóm vodíka. 38. Zlúčenina podľa nároku 36 alebo 37, kde R 3 je atóm vodíka, prípadne substituovaná arylová skupina alebo nižšia alkylová skupina. 39. Zlúčenina podía ktoréhokoľvek z nárokov 36 až 38, kde X 1 je skupina CH, C-nižšia alkoxyskupina, C-arylová skupina, skupina 307 C-halogén, skupina C-CN alebo atóm dusíka. 40. Zlúčenina podľa ktoréhokoľvek z nárokov 36 až 39, kde R 9 je atóm vodíka alebo alkylová skupina obsahujúca 1 až 4 atómy uhlíka. 41. Zlúčenina podľa ktoréhokoľvek z nárokov 36 až 40, kde p je 1. 42. Zlúčenina podľa ktoréhokoľvek z nárokov 36 až 41, kde R 10 je arylová skupina. 43. Zlúčenina podlá nároku 42, kde R 10 je viazaná v polohe 4 pyrolového kruhu. 44 . Zlúčenina podľa nároku 2 všeobecného vzorca Id H (Id) kde R 2 , R 3 , R 10 , X 1 a p sú definované ako v nároku 23, a jej proliečivá a farmaceutický prijateľné soli a solváty, napríklad hydráty, zlúčenín všeobecného vzorca Id a ich proliečiv. 45. Zlúčenina podľa nároku 44, kde R 2 je atóm vodíka, nižšia alkylová skupina, nižšia alkylová skupina substituovaná skupinou -CONY 3 Y 4 , nižšia alkylová skupina substituovaná karboxylovou skupinou, nižšia alkylová skupina substituovaná tetrazolylovou skupinou alebo nižšia alkylová skupina substituovaná hydroxylovou skupinou. 46. Zlúčenina podľa nárokov 44 alebo 45, kde R 3 je atóm vodíka, 308 pripadne substituovaná arylová skupina alebo nižšia alkylová skupina. 47. Zlúčenina podľa ktoréhokoľvek z nárokov 44 až 46, kde X 1 je skupina CH, C-nižšia alkoxyskupina, C-arylová skupina, skupina C-halogén, skupina C-CN alebo atóm dusíka. 48. Zlúčenina podľa ktoréhokoľvek z nárokov 44 až 47, kde p je 1. 49. Zlúčenina podľa ktoréhokoľvek z nárokov 44 až 48, kde R 10 je alkylová skupina. 50. Zlúčenina podľa nároku 49, kde R 10 je viazaná v polohe 4 fenylového kruhu. 51. Zlúčenina podľa nároku 2, vybraná zo skupiny, ktorú tvorí: 6- (5-metoxy-l-metyl-lH-indol-3-yl) -5/í-pyrolo [2,3-b]pyrazín;amid kyseliny 1-[l-metyl-3-(lH-pyrolo[2,3-b]pyrid-2-yl)-1Hindol-5-yloxy]cyklobutánkarboxylovej;2-(5-metoxy-1-metyl-lH-indol-3-yl)-lH-pyrolo[2,3-b]pyridín-4karbonitril;{1-[l-metyl-3-(5H-pyrolo[2,3-b] pyrazin-6-yl)-lH-indbl-5-yloxy]cyklobutyl}metanol;a jej proliečivá a farmaceutický prijateľné soli a solváty týchto zlúčenín a ich proliečiv. 52. Zlúčenina podľa nároku 2 alebo zodpovedajúce proliečivo alebo farmaceutický prijateľná soľ alebo solvát tejto zlúčeniny alebo jej proliečivá, na použitie na liečenie. 309 53. Zlúčenina podlá nároku 2 alebo zodpovedajúce proliečivo alebo farmaceutický prijateľná soľ alebo solvát tejto zlúčeniny alebo jej proliečiva, na použitie na liečenie pacienta trpiaceho alebo ohrozeného stavmi, ktoré sa môžu zlepšiť podávaním inhibítora katalytickej aktivity Syk kinázy. 54. Kompozícia podľa nároku 1, vyznaču ú c a sa tým, že sa použije na liečenie pacienta trpiaceho alebo ohrozeného stavmi, ktoré sa môžu zlepšiť podávaním inhibítora katalytickej aktivity Syk kinázy. 55. Kompozícia podľa nároku 1, vyznaču ú c a sa tým, že sa použije na liečenie zápalových ochorení. 56. Kompozícia podľa nároku 1, vy 57. 58. m, že sa použije na Kompozícia podľa m, že sa použije na Kompozícia podľa m, že sa použije na liečenie nároku liečenie nároku liečenie astmy. 1, vy psoriázy. 1, v zápalu y kĺbu. takejto zlúčeniny alebo jej proliečiva, na výrobu liečiva na liečenie pacienta trpiaceho alebo ohrozeného stavmi, ktoré sa 310 môžu zlepšiť podávaním inhibítora katalytickej aktivity Syk kinázy. 62. Použitie zlúčeniny podľa nároku 2 alebo zodpovedajúceho proliečiva alebo farmaceutický prijateľnej, soli alebo solvátu takejto zlúčeniny alebo jej proliečiva, na výrobu liečiva na liečenie astmy. 63. Použitie zlúčeniny podľa nároku 2 alebo zodpovedajúceho proliečiva alebo farmaceutický prijateľnej soli alebo solvátu takejto zlúčeniny alebo jej proliečiva, na výrobu liečiva na liečenie psoriázy. 64. Použitie zlúčeniny podľa nároku 2 alebo zodpovedajúceho proliečiva alebo farmaceutický prijateľnej soli alebo solvátu takejto zlúčeniny alebo jej proliečiva, na výrobu liečiva na liečenie zápalu kĺbu. 65. Použitie zlúčeniny podľa nároku 2 alebo zodpovedajúceho proliečiva alebo farmaceutický prijateľnej soli alebo solvátu takejto zlúčeniny alebo jej proliečiva, na výrobu liečiva na liečenie zápalového ochorenia čriev. 66. Použitie zlúčeniny podľa nároku 2 alebo zodpovedajúceho proliečiva alebo farmaceutický prijateľnej soli alebo solvátu takejto zlúčeniny alebo jej proliečiva, na výrobu liečiva na liečenie rakoviny. 67. Spôsob liečenia človeka alebo živočícha trpiaceho alebo ohrozeného stavmi, ktoré sa môžu zlepšiť podávaním inhibítora Syk kinázy tomuto pacientovi, vyznačujúci sa tým, že zahŕňa podávanie účinného množstva zlúčeniny podľa nároku 2 alebo zodpovedajúceho proliečiva alebo farmaceutický prijateľnej soli alebo solvátu tejto zlúčeniny alebo jej proliečiva tomuto 311 pacientovi. 68. Zlúčenina podlá uvedených nárokov, ktorou je zlúčenina uvedená v príkladoch.
Independent claims11
5,420 paragraphs in 13,257 sections, as filed
Technical field
The present invention relates to substituted azaindoles, their preparation, pharmaceutical compositions containing them and their pharmaceutical use in the treatment of diseases that may be affected by the inhibition of protein kinases.
BACKGROUND OF THE INVENTION
Protein kinases are involved in signaling that directs cell activation, growth and differentiation in response to extracellular mediators and environmental changes. In general, these kinases are divided into several groups; some preferably phosphorylate serine and / or threonine residues and some preferably phosphorylate tyrosine residues [SK Hanks and T. Hunter, FASEB J., 9, 576-596 (1995)]. Serine / threonine kinases include, for example, protein kinase C isoforms [AC Newton, J. Biol. Chem., 270, 28495-28498 (1995)] and a group of cyclin-dependent kinases such as cdc2 [J. Pins, Trends in Biochemical Sciences, 18, 195-197 (1995)]. Tyrosine kinases include membrane growth factor receptors such as epidermal growth factor receptor [S. Iwashita and M. Kobayashi, Celular Signaling, 4, 123-132 (1992)] and cytosolic non-receptor kinases such as p56tck, p59fYn, ZAP-70 and csk kinases [C. Chan et al., Ann. Rev. Immunol., 12, 555-592 (1994)].
Too high protein kinase activity occurs in a variety of diseases resulting from abnormal cell function, which may arise directly or indirectly, for example, by failure of the proper kinase control mechanism, in conjunction with, for example, mutation, overexpression, or inappropriate enzyme activation; or is caused by low production or overproduction of cytokines or growth factors that also participate in downstream or upstream kinase signaling. In all these cases, selective inhibition of kinase action may have a beneficial effect.
Syk is a 72 kDa cytoplasmic protein tyrosine kinase that is expressed by various hematopoietic cells and is a key element of some cascades that link antigen receptors and cellular responses. Therefore, Syk plays a central role in signaling the high affinity IgE receptor, FcεR1, in mast cells and in signaling the receptor antigen in T and B lymphocytes. Signal transduction pathways have common features in mast cells and T and B cells. The ligand binding domain of the receptor does not have intrinsic tyrosine kinase activity, but interacts with transfer subunits that contain immunoreceptor tyrosine activation motifs (ITAM) [M.
Ret, Nature, 338, 383-384 (1989)]. These motifs are present in both the β-γ subunits of the FcsR1, the ξ-subunit of the T cell receptor (TCR), and the IgGa and IgGP subunits of B cell receptors (BCR). [NS van Oers and A. Weiss, Seminars in Immunology, 7, 227-236 (1995)]. After antigen binding and multimerization, ITAM residues are phosphorylated by Src family protein tyrosine kinases. Syk belongs to a unique family of tyrosine kinases having two tandem domains of Src homology 2 (SH2) and a C-terminal catalytic domain. These SH2 domains bind with high affinity to ITAM, and this SH2-mediated association of Syk with an activated receptor stimulates Syk kinase activity and localizes Syk in the plasma membrane.
In Syk deficient mice mast cell degranulation is inhibited, suggesting that this is an important target for the development of mast cell stabilizing agents [PS Costelo, Oncogene, 13, 2595-2605 (1996)]. Similar studies have shown a critical role for Syk in BCR and TCR signaling [AM Cheng, Nature, 378, 303-306 (1995) and DH Chu et al., Immunological Reviews, 165, 167-180 (1998)]. Syk is also involved in eosinophil survival in response to IL-5 and GM-CSF [S. Yousefi et al., J. Exp. Med., 183,1407-1414 (1996)]. Despite the key role in signaling in mast cells, BCR and T cells, little is known about the mechanism by which Syk transmits downstream effectors. Two adapter proteins have been shown to be Syk substrates in B cells and mast cells, BLNK (B cell connecting protein, SLP-65) and SLP-76, which have been postulated to link Syk to downstream effectors [M. Ishiai et al., Immunity, 10, 117-125 (1999) and LR Hendricks-Taylor et al., J. Biol. Chem., 272, 1363-1367 (1997)]. Furthermore, Syk appears to play an important role in the CD40 signaling pathway, which plays an important role in B cell proliferation [M. Faris et al., J. Exp. Med., 179, 1923-1931 (1994)].
Syk is further involved in the activation of platelets stimulated with low affinity IgG receptor (Fc gamma-RIIA) or stimulated with collagen [F. Yanaga et al., Biochem. J., 311 (Pt.2), 471-478 (1995)].
Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase that participates in integrin-mediated signal transduction pathways. FAK is co-localized with integrins at focal contact sites, and activation of FAK and its tyrosine phosphorylation has been shown to depend on the binding of integrins to their extracellular ligands in a number of cell types. The results of some studies support the hypothesis that FAK inhibitors might be useful in the treatment of cancer. For example, FAK deficient cells migrate poorly in response to chemotactic signals, and high expression of the C-terminal domain of FAK blocks proliferation as well as chemotactic migration [Sieg et al., J. Cell Science, 112, 2677-2691 (1999); A. Richardson and T. Parsons, Cell, 97, 221-231 (1997)]; moreover, tumor cells treated with FAK antisense oligonucleotides lose their attachment and undergo apoptosis [Xu et al., Cell Growth Differ., 4, 413-418 (1996)]. FAK overexpression has been reported to occur in prostate, breast, thyroid, colon and lung cancer. FAK expression level correlates directly with tumors that are characterized by the most aggressive phenotype.
Of particular importance for embryonic development and organogenesis is anogenogenesis or the formation of new vessels by budding from pre-existing vasculature. Abnormally developed neovascularization occurs in rheumatoid arthritis, diabetic retinopathy and during tumor development [Folkman, Nat. Med., 1, 27-31 (1995)]. Angiogenesis is a complex multistep process that involves activation, migration, proliferation and survival of endothelial cells. A number of tumor angiogenesis studies in the last twenty years have defined a number of therapeutic targets including kinases, proteases, and integrins, which have led to the discovery of a number of new anti-angiogenic agents including KDR inhibitors, some of which are already clinically tested [Jekunen et al. 23, 263-286 (1997)]. Angiogenesis inhibitors can be used in the first line as support, as well as preventive in the onset or recurrence of malignancies.
Some proteins have been found in yeast and in Drosophila that are involved in chromosome segregation and spindle formation. The disruption of these proteins leads to poor chromosome segregation and monopolar or disrupted spindles. These kinases include the Ipli and aurora kinases of S. cerevisiae and drozophile, which are required for centrosome separation and chromosome segregation. Several laboratories have recently cloned and characterized one human homologue of yeast Ipli. This kinase referred to as Aurora2, STK15 or BTAK belongs to the serine / threonine kinase family. Bischoff et al. have shown that Aurora2 is an oncogene and is widespread in human colorectal tumors [EMBO J, 17, 3052-3065 (1998)] and has also been shown in epithelial tumors such as breast cancer.
SUMMARY OF THE INVENTION
A new class of substituted azaindoles has now emerged which have significant pharmaceutical properties, in particular the ability to inhibit protein kinases, more particularly the ability to selectively inhibit Syk kinase.
Therefore, one object of the present invention is a pharmaceutical composition comprising a compound of Formula I
<img file="SK9012002A3_D0001.tif" />
(I) where
R<sup>1</sup> is aryl or heteroaryl each optionally substituted with one or more groups selected from the group consisting of acyl, alkylenedioxy, alkenyl, alkenyloxy, alkynyl, aryl, cyano, halogen, hydroxyl, heteroaryl, heterocycloalkyl, nitro , group R<sup>4</sup>, -C (= O) -NY4<sup>2</sup>, -C (= O) -OR<sup>5</sup>, -NY4<sup>2</sup>, the group -N (R<sup>6</sup>) -C (= O) -R<sup>7</sup>, the group -N (R<sup>6</sup>) -C (= O) -NY<sup>3</sup>Y<sup>4</sup>, the group -N (R<sup>6</sup>) -C (-O) -OR<sup>7</sup>, the group -N (R<sup>6</sup>) -SO 2 R<sup>7</sup>, the group -N (R<sup>6</sup>) -SO2-NY<sup>3</sup>Y<sup>4</sup>, -SO group<sub>2</sub>-NY<sup>1</sup>Y<sup>2</sup> and -Z<sup>2</sup>R<sup>4</sup>;
R<sup>2</sup> is a hydrogen atom, an acyl group, a cyano group, a halogen atom, a lower alkenyl group or a lower alkyl group optionally substituted with a substituent selected from the group consisting of cyano, heteroaryl, heterocycloalkyl, -Z<sup>1</sup>R<sup>8</sup>, -C (= O) -NY<sup>3</sup>Y<sup>4</sup>, -CO 2 R group<sup>8</sup>, -NY group<sup>3</sup>Y<sup>4</sup>, the group -N (R<sup>6</sup>) -C (= O) -R<sup>7</sup>, the group -N (R<sup>6</sup>) -C (= O) -NY<sup>3</sup>Y<sup>4</sup>, the group -N (R<sup>6</sup>) -C (= O) -OR<sup>7</sup>, -N (R 0) -SO 2 -R<sup>7</sup>, the group -N (R<sup>6</sup>) -SO<sub>2</sub>-NY<sup>3</sup>Y<sup>4</sup> and one or more halogen atoms;
R<sup>3</sup> is hydrogen, aryl, cyano, halogen, heteroaryl, lower alkyl, -C (= O) -OR<sup>5</sup> or -C (= O) -NY<sup>3</sup>Y;
R<sup>4</sup> is an alkyl, cycloalkyl or cycloalkylalkyl group, each optionally substituted with a substituent selected from the group consisting of aryl, cycloalkyl, cyano, halogen, heteroaryl, heterocycloalkyl, -CHO (or 5-, 6-, or an alkyl group thereof); 7-membered cyclic acetal derivative), -C (= O) -NY2<sup>2</sup>, -C (= O) -OR<sup>5</sup>, -NY group<sup>1</sup>Y<sup>2</sup>, the group -N (R<sup>6</sup>) -C (= O) -R<sup>7</sup>, the group -N (R<sup>6</sup>) -C (= O) -NY<sup>3</sup>Y<sup>4</sup>, the group -N (R<sup>6</sup>) -SO 2 R<sup>7</sup>, the group -N (R<sup>6</sup>) -SO2-NY<sup>3</sup>Y<sup>4</sup>, -OR group<sup>7</sup> and one or more groups selected from the group consisting of hydroxyl and carboxyl;
R<sup>5</sup> is hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl;
R c is hydrogen or lower alkyl;
R<sup>7</sup> is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, hetero. aryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;
R<sup>8</sup> is hydrogen or lower alkyl;
X<sup>1</sup> is nitrogen, CH, C-halogen, C-CN, CR<sup>7</sup>, C-NY<sup>3</sup>Y<sup>4</sup>, group C-OH, group CZ<sup>2</sup>R<sup>7</sup>, CC (= O) -OR<sup>5</sup>, CC (= O) -NY<sup>3</sup>Y<sup>4</sup>, CN (R<sup>8</sup>) -C (= O) -R<sup>7</sup>, group C-SO2-NY<sup>3</sup>Y<sup>4</sup>, CN (R<sup>8</sup>) -SO 2 -R<sup>7</sup>, C-alkenyl, C-alkynyl or C-NO<sub>2</sub>;
Y<sup>1</sup> and Y<sup>2</sup> are independently hydrogen, alkenyl, aryl, cycloalkyl, heteroaryl or alkyl optionally substituted by one or more groups selected from the group consisting of aryl, halogen, heteroaryl, hydroxyl, -C (= 0) -NY<sup>3</sup>Y<sup>4</sup>, -C (= O) -OR<sup>5</sup>, -NY group<sup>3</sup>Y<sup>4</sup>, the group -N (R<sup>6</sup>) -C (= O) -R<sup>7</sup>, the group -N (R<sup>6</sup>) -C (= O) -NY<sup>3</sup>Y<sup>4</sup>, the group -N (R<sup>6</sup>) -SO 2 R<sup>7</sup>, the group -N (R<sup>6</sup>) -SO2-NY<sup>3</sup>Y<sup>4</sup> and -OR<sup>7</sup>; or the group -NY<sup>1</sup>Y<sup>2</sup> to form a cyclic amine;
Y<sup>3</sup> and Y<sup>4</sup> are, independently of one another, a hydrogen atom, an alkenyl group, an alkyl group, an aryl group, an arylalkyl group, a cycloalkyl group, a heteroaryl group or a heteroarylalkyl group; or the group -NY<sup>3</sup>Y<sup>4</sup> to form a cyclic amine;
<td>FROM<sup>1</sup></td><td>is an</td><td>atom</td><td>oxygen or</td><td>a sulfur atom;</td>
<td>from<sup>2</sup></td><td>is an</td><td>atom</td><td>oxygen or</td><td>Group S (0)<sub>n</sub>;</td>
<td>N</td><td>is an</td><td>number</td><td>0 or whole</td><td>number 1 or 2;</td>
and their corresponding N-oxides, their prodrugs, their acid bioisosteres; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds and their N-oxides and prodrugs thereof and their acidic bioisomers; together with one or more pharmaceutically acceptable carriers or excipients.
A further object of the invention are compounds of formula I as defined above, excluding compounds selected from the group consisting of:
2-phenyl-1H-pyrrolo [2,3-b] pyridine,
2- (4-bromophenyl) -3-methyl-1H-pyrrolo [2,3-b] pyridine, 4- (3-methyl-1H-pyrrolo [2,3-b] pyrid-2-yl) benzoic acid methyl ester .
2- (4-chlorophenyl) -lH-pyrrolo [2,3-b] pyridine,
2- (4-methoxyphenyl) -lH-pyrrolo [2,3-b] pyridine,
5-methyl-2-phenyl-lH-pyrrolo [2,3-b] pyridine,
4-methyl-2-phenyl-lH-pyrrolo [2,3-b] pyridine,
2- (pyrid-3-yl) -1H-pyrrolo [2,3-b] pyridine, 4- (3-methyl-1H-pyrrolo [2,3-b] pyrid-2-yl) benzoic acid,
2- (4-methoxyphenyl) -3-methyl-1H-pyrrolo [2,3-b] pyridine,
2- (4-methylphenyl) -3-methyl-1H-pyrrolo [2,3-b] pyridine, 4- (3-methyl-1H-pyrrolo [2,3-b] pyridine-2-isopropyl ester) yl) benzoic acid,
2-phenyl-3-methyl-1H-pyrrolo [2,3-b] pyridine,
5-bromo-2-phenyl-3-methyl-1H-pyrrolo [2,3-b] pyridine,
6-chloro-2-phenyl-1H-pyrrolo [2,3-b] pyridine,
6-chloro-4-methyl-2-phenyl-lH-pyrrolo [2,3-b] pyridine,
4-methyl-2-phenyl-1H-pyrrolo [2,3-b] pyrid-3-ylcarboxaldehyde, (2-phenyl-1H-pyrrolo [2,3-b] pyrid-3-yl) acetonitrile,
2-phenyl-3- (prop-l-enyl) -lH-pyrrolo [2,3-b] pyridine,
4-methyl-2-phenyl-1H-pyrrolo [2,3-b] pyrid-3-ylcarboxaldehyde, dimethyl (2-phenyl-1H-pyrrolo [2,3-b] pyrid-3-ylmethyl) amine, 2,2'-diphenyl-1H, 1'H-3,3'-bi (pyrrolo [2,3-b] pyridinyl),
2- (2-phenyl-1H-pyrrolo [2,3-b] pyrid-3-yl) acetamide,
3-allyl-2-phenyl-1H-pyrrolo [2,3-b] pyridine, (2-phenyl-1H-pyrrolo [2,3-b] pyrid-3-yl) acetonitrile,
2-phenyl-1H-pyrrolo [2,3-b] pyridine-3-carboxaldehyde,
3- (morpholin-4-yl) methyl-2-phenyl-1H-pyrrolo [2,3-b] pyridine,
N- [2- (2-phenyl-lH-pyrrolo [2,3-b] pyridin-3-yl) ethyl] acetamide,
6-phenyl-5H-pyrrolo [2,3-b] pyrazine,
6- (4-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine,
6- (4-chlorophenyl) -5H-pyrrolo [2,3-b] pyrazine,
6- (2-chlorophenyl) -5H-pyrrolo [2,3-b] pyrazine,
3-methyl-6-phenyl-5H-pyrrolo [2,3-b] pyrazine,
2-methyl-6-phenyl-5 H -pyrrolo [2,3- b] pyrazine, a
I
7-methyl-6-phenyl-5H-pyrrolo [2,3-b] pyrazine.
As used herein, the term "compounds of the present invention (and equivalents thereof) refers to compounds of formula I as described above, and includes, as the context requires, prodrugs, pharmaceutically acceptable salts and solvates, for example hydrates. Similarly, in the case of intermediates, whether claimed separately or not, the salts and solvates thereof are also contemplated. For the sake of clarity, they are sometimes included in the text where the context permits, but these examples are purely illustrative and do not exclude other cases.
Unless otherwise stated, the terms in the description have the following meanings:
“The patient refers to both human and other mammals.
"An acidic bioisoster is a group characterized by ehematic and physical similarity that leads to very similar biological properties to a carboxyl group [see Lipinski," Bioisosterism in Drug Design, Annual Reports in Medicinal Chemistry, 21, 283 (1986); Yun, & quot; Application of Bioisosterism to New Drug Design, Hwahak Sekye, 33, 576-579 (1993);
Zhao, “Bioisosteric Replacement and Development of Lead Compounds in Drug Design, Huaxue Tongbao, 1995, 34-38; Graham, "Theoretical Studies Applied to Drug Design: Ab initio Electronic Distributions in Bioisosteres, Theochem, 343, 105-109 (1995)].
Examples of suitable acid bioisomers are the group -C (= O) -NHOH, the group -C (= O) -CH<sub>2</sub>OH, -C (= O) -CH<sub>2</sub>SH, -C (= O) -NH-CN, sulfo, phosphono, alkylsulfonylcarbamoyl, tetrazolyl, arylsulfonylcarbamoyl, heteroarylsulfonylcarbamoyl, N-methoxycarbamoyl, 3-hydroxy-3-cyclobutene-1,2-dione, 3 5-dioxo-1,2,4-oxadiazolidinyl or heterocyclic phenols such as 3-hydroxyisoxazolyl and 3-hydroxy-1-methylpyrazolyl.
"Acyl is an H-CO- group or an alkyl-CO- group, the alkyl group of which is defined below.
"Acylamino is an acyl-ΝΗ- group whose acyl group is as previously defined.
"Alkenyl is an aliphatic hydrocarbon group containing a carbon-carbon double bond and which may be straight or branched with 2 to 15 carbon atoms in the chain. Preferred alkenyl groups have 2 to 12 carbon atoms in the chain; more preferably 2 to 6 carbon atoms in the chain (for example 2 to 4 carbon atoms). "Branched means that one or more lower alkyl groups, such as methyl, ethyl or propyl, are attached to a linear chain, in this case a linear alkenyl group. "A lower alkenyl group is a group that contains 2 to 4 carbon atoms in the chain, which may be straight or branched. Examples of alkenyl groups are ethenyl, propenyl, n-butenyl, isobutenyl, 3-methylbut-2-enyl, n-pentenyl, heptenyl, octenyl, cyclohexylbutenyl and decenyl.
"Alkenyloxy" means an alkenyl-Ο- group whose alkenyl group has already been defined. An exemplary alkenyloxy group is allyloxy.
"Alkoxy" is an alkyl-Ο- group, the alkyl group of which is defined below. An exemplary alkoxy group is difluoromethoxy, methoxy, trifluoromethoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy and heptoxy.
"Alkoxycarbonyl" is an alkyl-O-CO- group, the alkyl group of which is defined below. An exemplary alkoxycarbonyl group is methoxycarbonyl and ethoxycarbonyl.
"Unless otherwise stated, an alkyl group is an aliphatic hydrocarbon group which may be straight or branched and may have from 1 to 15 carbon atoms in the chain and optionally substituted by one or more halogen atoms. Preferred alkyl groups have 1 to 6 carbon atoms. "A lower alkyl group such as a group or part of a lower alkoxy group, a lower alkylthio group, a lower alkylsulfinyl group or a lower alkylsulfonyl group, unless otherwise specified, is an aliphatic hydrocarbon group which may have a straight or branched chain of 1 to 4 carbon atoms. Exemplary alkyl groups include methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, n-pentyl, 3-pentyl, heptyl, octyl, nonyl, decyl and dodecyl. An exemplary alkyl group substituted with one or more halogen atoms is a trifluoromethyl group.
"Alkylene is an aliphatic divalent group derived from a straight or branched alkyl group as defined above. Exemplary alkylene groups are methylene, ethylene and trimethylene.
"Alkylenedioxy is -O-alkylene-O-, wherein the alkylene group is as previously defined. Examples of alkylenedioxy groups are methylenedioxy and ethylendioxy.
"An alkylsulfinyl group is an alkyl-SO- group whose alkyl group has already been defined. Preferred alkylsulfinyl groups are those wherein the alkyl group contains 1 to 4 carbon atoms.
"An alkylsulfonyl group is an alkyl-SO group<sub>2</sub>- whose alkyl group is as previously defined. Preferred alkylsulfonyl groups are those wherein the alkyl group contains 1 to 4 carbon atoms.
"Alkylsulfonylcarbamoyl is an alkyl-SO 2 -NH-C (= O) - group whose alkyl group is as previously defined. Preferred alkylsulfonylcarbamoyl groups are those wherein the alkyl group contains 1 to 4 carbon atoms.
"Alkylthio is an alkyl-S- group whose alkyl group is as previously defined. Exemplary alkylthio are methylthio, ethylthio, isopropylthio and heptylthio.
"An alkynyl group is an aliphatic hydrocarbon group containing a carbon-carbon triple bond and which may be straight or branched and may contain 2 to 15 carbon atoms in the chain. Preferred alkynyl groups have 2 to 12 carbon atoms in the chain, more preferably 2 to 6 carbon atoms (for example 2 to 4 carbon atoms). Exemplary alkynyl groups are ethynyl, propynyl, n-butynyl, isobutinyl, 3-methylbut-2-ynyl and n-pentinyl.
“Aroyl is. an aryl-CO- group, the aryl group of which is defined below. Exemplary of the aroyl group are benzoyl and 1- and 2-naphthoyl.
"Aroylamino is an aroyl-ΝΗ- group whose aroyl group has already been defined.
"An aryl group as a group or part of a group is:
(i) an optionally substituted monocyclic or multicyclic aromatic carbocyclic group having 6 to 14 carbon atoms, such as phenyl or naphthyl; or (ii) an optionally substituted partially saturated multicyclic aromatic carbocyclic group, wherein the aryl group and the cycloalkyl or cycloalkenyl group are joined to form a cyclic structure such as a tetrahydronaphthyl, indenyl or indanyl ring.
Unless otherwise indicated, the aryl group may be substituted with one or more aryl group substituents, which may be the same or different, wherein the "aryl group substituent" may be, for example, acyl, acylamino, alkoxy, alkoxycarbonyl, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, alkylsulfonyl. alkylthio, aroyl, aroylamino, aryl, arylalkyloxy, arylalkyloxycarbonyl, arylalkylthio, aryloxy, aryloxycarbonyl, arylsulfinyl, arylsulfonyl, arylthio, carboxy (or acidic bioisoster), cyano, halogen, heteroaroyl, heteroaryl, heteroaryl, heteroarylalkyloxy, heteroarylalkyloxy, heteroarylalkyloxy, arylsulfonyl, heteroarylalkyloxy, arylsulfinyl, arylsulfinyl, arylsulfonyl, arylsulfonyl, arylsulfonyl, NY<sup>3</sup>Y<sup>4</sup>, -CONY group<sup>3</sup>Y<sup>4</sup>, -SO group<sub>2</sub>NY<sup>3</sup>Y<sup>4</sup>, -NY<sup>3</sup>-C (= O) -alkyl, -NY<sup>3</sup>SO2-alkyl or alkyl optionally substituted by aryl, heteroaryl, hydroxyl or -NY<sup>3</sup>Y<sup>4</sup>.
"Arylalkyl is an arylalkyl- group whose aryl and alkyl groups are as previously defined. Preferred arylalkyl groups contain alkyl groups having 1 to 4 carbon atoms. Exemplary arylalkyl groups are benzyl, 2-phenethyl and naphthalenomethyl.
"Arylalkyloxy is an arylalkyl-Ο- group whose arylalkyl group has already been defined. An exemplary arylalkyloxy group is benzyloxy and 1- or 2-naphthalenemethoxy.
"Arylalkyloxycarbonyl is an arylalkyl-O-CO- group whose arylalkyl group is as defined above. An exemplary arylalkyloxycarbonyl group is benzyloxycarbonyl.
"Arylalkylthio is an arylalkyl-S- group whose arylalkyl group has already been defined. An exemplary arylalkylthio group is benzylthio.
"Aryloxy" is an aryl-Ο- group whose aryl group has already been defined. Exemplary aryloxy groups are phenoxy and naphthoxy, each of which may be optionally substituted.
"Aryloxycarbonyl is an aryl-OC (= O) - group whose aryl group has already been defined. An exemplary aryloxycarbonyl group is a phenoxycarbonyl group and a naphthoxycarbonyl group.
"Arylsulfinyl is an aryl-SO- group whose aryl group is as previously defined.
Arylsulfonyl is aryl-SO<sub>2</sub>- whose aryl group has already been defined.
Arylsulfonylcarbamoyl is aryl-SO<sub>2</sub>-NH-C (= O) -, the aryl group of which has already been defined.
"Arylthio is an aryl-S- group whose aryl group is as previously defined. Exemplary arylthio are phenylthio and naphthylthio.
"Azaheteroaryl is an aromatic carbocyclic group containing 5 to 10 ring atoms, one of which is a nitrogen atom and the others selected from the group consisting of a carbon atom, an oxygen atom, a sulfur atom and a nitrogen atom. Examples of azaheteroaryl groups are benzimidazolyl, imidazolyl, indazolinyl, indolyl, indolyl, isoquinolyl, pyridyl, pyrimidinyl, pyrrolyl, quinolyl, quinazolinyl and tetrahydroindolizinyl.
"A cyclic amine is a 3- to 8-membered monocyclic cycloalkyl ring system wherein one of the ring carbon atoms is replaced by a nitrogen atom and which:
(i) it may also contain other heteroatom-containing groups such as oxygen, sulfur, SO2<sub>2</sub> or NY<sup>7</sup> (where Y<sup>7 </sup>is hydrogen, alkyl, aryl, arylalkyl, -C (= O) -R<sup>7</sup>, -C (= O) -OR<sup>7</sup> or -SO<sub>2</sub>R<sup>7</sup>); and (ii) may be linked to another aryl group (e.g., phenyl), heteroaryl (e.g., pyridyl), heterocycloalkyl or cycloalkyl to form a bicyclic or tricyclic ring system. Exemplary cyclic amines are pyrrolidine, piperidine, morpholine, piperazine, indoline, pyrindoline, tetrahydroquinoline and the like.
"A cycloalkenyl group is a non-aromatic monocyclic or multicyclic ring system containing at least one C 3 -C 10 carbon-carbon double bond. An exemplary monocyclic cycloalkenyl ring is cyclopentenyl, cyclohexenyl and cycloheptenyl.
"A cycloalkyl group is a saturated monocyclic or bicyclic ring system containing 3 to 10 carbon atoms optionally substituted with an oxo group. An exemplary monocyclic cycloalkyl ring is a C 3 -C 8 cycloalkyl group such as a cyclopropyl group, a cyclopentyl group, a cyclohexyl group, and a cycloheptyl group.
"Cycloalkylalkyl" is a cycloalkylalkyl- group whose cycloalkyl and alkyl groups have already been defined. Exemplary monocyclic cycloalkylalkyl groups are cyclopropylmethyl, cyclopentylmethyl, cyclohexylmethyl and cycloheptylmethyl.
"A halogen atom refers to a fluorine atom, a chlorine atom, a bromine atom or an iodine atom. Fluorine and chlorine atoms are preferred.
"Heteroaroyl is a heteroaryl-C (= O) - group, the heteroaryl group of which is defined below. An exemplary heteroaryl group is pyridylcarbonyl.
"Heteroaroylamino" is a heteroaroyl-NH- group, the heteroaryl group of which is defined below.
"A heteroaryl group as a group or part of a group is:
(i) an optionally substituted aromatic monocyclic or multicyclic organic group of 5 to 10 ring atoms, one or more of which is an element other than carbon, such as nitrogen, oxygen or sulfur (examples of such groups are benzimidazolyl, benzothiazolyl, furyl, imidazolyl, indolyl, indolizinyl, isoxazolyl, isoquinolyl, isothiazolyl, oxadiazolyl, pyrazinyl, pyridazinyl, pyrazolyl, pyridyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolinyl, quinolyl, 1,3,4-thiadiazolyl, thiazolyl, thienyl and triazolyl, which are optionally substituted, if not mentioned otherwise, one or more aryl substituents as defined above);
(ii) an optionally substituted partially saturated multicyclic heterocarbocyclic group whose heteroaryl group and cycloalkyl group or cycloalkenyl group are joined to form a cyclic structure (examples of such groups are pyrindanyl groups optionally substituted with one or more "aryl substituents" as defined above, unless otherwise stated). Optional substituents are, unless otherwise indicated, one or more "aryl groups" as defined above.
"Heteroarylalkyl is a heteroarylalkyl- group, the heteroaryl group and the alkyl group of which have already been defined. Preferred heteroarylalkyl groups contain alkyl groups having 1 to 4 carbon atoms. An exemplary heteroarylalkyl group is pyridylmethyl.
"Heteroarylalkyloxy is a heteroarylalkyl-O- group whose heteroarylalkyl group has already been defined. An exemplary heteroaryloxy group is an optionally substituted pyridylmethoxy group.
"Heteroaryloxy" is a heteroaryl-Ο- group whose heteroaryl group has already been defined. An exemplary heteroaryloxy group is an optionally substituted pyridyloxy group.
"Heteroarylsulfonylcarbamoyl group is a heteroaryl-SO 2 -NH-C (= O) group whose heteroaryl group has already been defined.
"Heterocycloalkyl is:
(i) a cycloalkyl group having 3 to 7 ring atoms of which is one or more heteroatoms or heteroatom containing groups selected from the group consisting of oxygen, sulfur and NY<sup>7</sup>, and optionally substituted by oxo;
(ii) a partially saturated multicyclic heterocarbocyclic group, wherein each aryl (or heteroaryl) ring may optionally be substituted with one or more "aryl substituents" and a heterocycloalkyl group linked to each other to form a cyclic structure. Examples of such groups are chromanyl, dihydrobenzofuryl, indolinyl and pyrindolinyl.
"Heterocycloalkylalkyl" is a heterocycloalkylalkyl- group whose heterocycloalkyl and alkyl groups have already been defined.
"A prodrug is a compound that can be converted in vivo by metabolic means (e.g., hydrolysis) to a compound of Formula I, including its N-oxides. For example, an ester of a compound of formula I containing a hydroxyl group can be converted into the parent compound by in vivo hydrolysis. Alternatively, an ester of a compound of formula (I) containing a carboxyl group can be converted into the parent compound by in vivo hydrolysis.
Suitable esters of the compounds of formula I containing a hydroxyl group are, for example, acetates, citrates, lactates, tartrates, malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-p-hydroxynaphthoates, gentisates, isethionates , methanesulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, cyclohexylsulfamates and quinates.
Suitable esters of compounds of formula I containing a carboxyl group are described, for example, in FJ Leinweber, Drug Metab. Res., 18, 379 (1987).
Suitable esters of the compounds of formula I containing -L<sup>1</sup>Both the -Y carboxyl group and the hydroxyl group are lactones formed by the elimination of water from said carboxyl group and the hydroxyl group. Examples of such lactones are caprolactones and butyrolactones.
A suitable group of esters of the compounds of formula I containing a hydroxyl group can be prepared from the acids described by Bundgaard et al., J. Med. Chem., 32, 2503-2507 (1989) and include substituted (aminomethyl) benzoates, for example dialkylaminomethylbenzoates, in which two alkyl groups may be either linked and / or interrupted by an oxygen atom or optionally substituted nitrogen atom, for example an alkylated nitrogen atom, more specifically (morpholinomethyl) benzoates, for example 3- or 4- (morpholinomethyl) benzoates and (4-alkylpiperazin-1-yl) benzoates, for example 3- or 4- (4-alkylpiperazin-1-yl) benzoates.
If the compounds of the present invention contain a carboxyl group or are a sufficiently acidic bioisoster, they may form base addition salts which are more suitable for use; in practice, the use of a salt is actually equivalent to the use of a free acid. Bases which can be used for the preparation of basic addition salts suitably include those which, by reaction with the free acids, form pharmaceutically acceptable salts, i. salts whose cations are non-toxic to patients at a pharmaceutical dose such that the beneficial inhibitory effects of the inherent free base are not impaired by cationic side effects. The pharmaceutically acceptable salts of the alkali and alkaline earth metals of the present invention are derived from the following bases: sodium hydride, sodium hydroxide, potassium hydroxide, calcium hydroxide, aluminum hydroxide, lithium hydroxide, magnesium hydroxide, zinc hydroxide, ammonia, ethylenediamine, N-methylglucamine, lysine, arginine, ornithine, choline, N, N'-dibenzylethylenediamine, diethyl amine , procaine, N-benzylphenethylamine, diethylamine, piperazine, tris (hydroxymethyl) aminomethane, tetramethylammonium hydroxide and the like.
Certain compounds of the present invention are basic and suitable for use in the form of the free base or a pharmaceutically acceptable acid addition salt thereof.
Acid addition salts are more suitable for use, and in practice the use of salt is essentially equivalent to the use of the free base. Acids which can be used to prepare acid addition salts suitably include those which, by reaction with the free base, provide pharmaceutically acceptable salts, i.e. salts whose anions are non-toxic to the patient in a pharmaceutical dosage of salt, so that the beneficial inhibitory effects of the free base are not impaired. side effects of anions. While pharmaceutically acceptable salts of said basic compounds are preferred, all customary acid addition salts are suitable as the free base source, although the particular salt itself is only desirable as an intermediate, such as when the salt is formed for purification and identification purposes only or when is used as an intermediate for the preparation of pharmaceutically acceptable salts by ion exchange. The pharmaceutically acceptable salts of the present invention are derived from mineral and organic acids and include hydrohalides such as hydrochlorides and hydrobromides, sulfates, phosphates, nitrates, sulfamates, acetates, citrates, lactates, tartrates, malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-p-hydroxynaphthoates, gentisates, isethionates, di-p-toluyl tartrates, methanesulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, cyclohexylsulfamates and quinates.
The salts of the present invention are suitable both as active compounds and for purification purposes, for example by utilizing the solubility differences between the salt and the parent compound, by-products and / or starting materials by techniques well known to those skilled in the art.
With reference to the above general formula I, the following groups are preferred:
R<sup>1</sup> in particular, an optionally substituted heteroaryl group, in particular an optionally substituted azaheteroaryl group, may be present. An exemplary example of optionally substituted azaheteroaryl<sub>from </sub>The groups are indolyl, furyl, pyridyl, pyrrolyl, pyrazolyl, quinolyl, isoquinolyl, imidazolyl, indazolyl, indolizinyl, tetrahydroindolizinyl and indazolinyl. Optional substituents are one or more groups selected from the group consisting of alkylenedioxy, alkenyl, alkenyloxy, aryl, carboxyl (or bioisoster thereof), cyano21, halogen, hydroxyl, heteroaryl, heterocycloalkyl, R<sup>4</sup>, -C (= O) -R<sup>4</sup>, -C (= O) -NY<sup>1</sup>Y<sup>2</sup>, -NY group<sup>1</sup>Y<sup>2</sup> and -OR<sup>4</sup>. Group R<sup>1</sup> is more preferably an optionally substituted indolyl group, an optionally substituted indolizinyl group or an optionally substituted pyrrolyl group, and in particular an optionally substituted indol-3-yl group, indolizin-1-yl group or an optionally substituted pyrrol-3-yl group.
R<sup>1</sup> it may also be in particular an optionally substituted aryl group, in particular an optionally substituted phenyl group. Optional substituents are one or more groups selected from the group consisting of alkylenedioxy, halogen, R<sup>4</sup>, -YY ^ group<sup>2</sup> and -OR<sup>4</sup>. Group R<sup>1</sup> is even more advantageous
4-substituted phenyl, more particularly 4-tert-butylphenyl.
R<sup>2</sup> in particular, it may be a hydrogen atom.
R<sup>2</sup> it may also be in particular a halogen atom.
R<sup>2</sup> in particular, it may also be a lower alkyl group optionally substituted by a carboxyl group, a cyano group, a halogen atom, a hydroxyl group, a tetrazolyl group or a -CONY group<sup>3</sup>Y<sup>4</sup>.
R<sup>2</sup> it may also be in particular a lower alkenyl group.
R<sup>3</sup> in particular, it may also be a hydrogen atom.
R<sup>3</sup> it may also be in particular an optionally substituted aryl group, in particular an optionally substituted phenyl group.
R<sup>3</sup> it may also in particular be a lower alkyl group, for example a methyl group.
X<sup>1</sup> it may also be in particular a nitrogen atom.
X<sup>1</sup> it may also be in particular CH.
X<sup>1</sup> it may also be in particular C-lower alkoxy, in particular C-OCH 3.
X<sup>1</sup> it may also be in particular a C-aryl group, in particular a C-phenyl group.
X<sup>1</sup> it may in particular also be a C-halogen atom, in particular a C-Cl group.
X<sup>1</sup> it may also in particular be a C-CN group.
It is to be understood that the present invention covers all suitable combinations of the particular and preferred groups disclosed herein.
A particularly preferred class of compounds of the present invention are those of formula Ia
<img file="SK9012002A3_D0002.tif" />
where
R<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> have already been defined;
R<sup>9</sup> is a hydrogen atom, a R group<sup>4</sup>, alkenyl or heterocycloalkyl;
R<sup>10</sup> is alkenyloxy, carboxyl (or bioisoster thereof), cyano, halogen, hydroxyl, heteroaryl, R<sup>4</sup>, -C (= O) -R<sup>4</sup>, -C (= O) -NY<sup>X</sup>Y<sup>2</sup>, -OR group<sup>4</sup>, the group -N (R<sup>6</sup>) -C (= O) -R<sup>7</sup>, the group -N (R<sup>6</sup>) -SO 2 R<sup>7</sup> or -NY<sup>X</sup>Y<sup>2</sup>; and p is 0 or an integer of 1 or 2;
and prodrugs thereof, and pharmaceutically acceptable salts and solvates thereof, for example, hydrates, compounds of formula Ia, and prodrugs thereof.
Preference is given to compounds of the formula Ia in which R @ 1<sup>2</sup> is a hydrogen atom.
Preference is given to compounds of the formula Ia in which R @ 1<sup>3</sup> is hydrogen, optionally substituted aryl (e.g., phenyl). <sup>:</sup> or a lower alkyl group (for example a methyl group), in particular a hydrogen atom.
Preferred are compounds of formula Ia wherein X<sup>1</sup> is CH, C-lower alkoxy (e.g. C-OCH<sub>3</sub>), C-aryl (for example C-phenyl), C-halogen (for example C-Cl), C-CN or nitrogen.
Preference is given to compounds of the formula Ia in which R @ 1<sup>9</sup> is an:
(i) a hydrogen atom;
(ii) an alkyl group containing 1 to 4 carbon atoms [e.g. (iii) an alkyl group containing a bold hydroxyl group -CH<sub>2</sub>CH<sub>2</sub>OH or -CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>OH];
1-4 carbon atoms [e.g., substi-CH2OH, 1-4 carbon atoms (iv) alkyl group containing bold -N (R)<sup>6</sup>C (= O) -R<sup>7</sup> [e.g. -CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>NHC (= O) CH 3];
(v) alkyl having 1 to 4 carbon atoms substituted<sub>2</sub> is -C (= O) -NY<sup>1</sup>Y<sup>2</sup> [for example —CH<sub>2</sub>—C (= O) —YC];
or (vi) a cycloalkylalkyl group substituted with a hydroxyl group<sub>2</sub>C-CH<sub>2</sub>
II nou [e.g. —C — CH<sub>2</sub> ]·
CH<sub>2</sub>OH
Particularly preferred are compounds of formula Ia wherein R @ 1<sup>9</sup> is hydrogen or -CH<sub>3</sub>.
Particularly preferred are compounds of formula Ia wherein R @ 1<sup>10 </sup>is an:
(i) a hydroxyl group;
(ii) -OR<sup>4</sup>where R<sup>4</sup> is alkyl [e.g., -OCH 3];
(iii) -OR<sup>4</sup>where R<sup>4</sup> is an alkyl or cycloalkylalkyl group substituted with one or more hydroxyl groups [e.g. -OCH group]<sub>2</sub>CH<sub>2</sub>OH, -OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>OH
H<sub>?</sub>C-CH
II
-OCH (CH<sub>3</sub>) CH<sub>2</sub>OH, -OCH<sub>2</sub>CH (OH) CH<sub>3</sub>, C - CH - OCH (OH) CH<sub>2</sub>OH or
I ch<sub>2</sub>oh
OCH<sub>2</sub>CH (OH) CH<sub>2</sub>OH];
(iv) -OR<sup>4</sup>where R<sup>4</sup> is an alkyl group substituted with one or more alkoxy groups [e.g., -OCH (CH<sub>3</sub>) CH<sub>2</sub>OCH<sub>3</sub>] ;
(v) -OR<sup>4</sup>where R<sup>4</sup> is an alkyl or cycloalkyl group substituted with one or more carboxyl groups;
H<sub>2</sub>C-CH<sub>2</sub>
I pins [e.g. -OCH<sub>2</sub>WHAT<sub>2</sub>H, -OCH (CH<sub>3</sub>) WHAT<sub>2</sub>H or __q_ς_qu];
I
WHAT<sub>2</sub>H (vi) -OR<sup>4</sup>where R<sup>4</sup> the cycloalkyl group is substituted
H<sub>2</sub>C-CH<sub>2</sub> -C (= O) -NY<sup>1</sup>Y<sup>2</sup> [for example, __q_q_or
I <sup>2</sup> CON<sub>2</sub> h<sub>2</sub>C = CH<sub>2</sub> -O-C-CH<sub>2</sub>
CONHCH 3 (vii) -N (R 3);<sup>5</sup>) -C (= O) -R<sup>7</sup> [e.g. -NHC (= O) CH<sub>3</sub>] ;
<td>(viii) group</td><td>CON<sup>1</sup>Y<sup>2</sup> [e.g., -CONH<sub>2</sub>, -CONHCH<sub>3</sub>,</td>
<td>-CONHCH (CH<sub>2</sub>OH) <sub>2</sub>,</td><td>-CONHCH<sub>2</sub>CH<sub>2</sub>OH, -CONHC (CH<sub>3</sub>) 2CH2OH, -CONHCH2CHOCH3,</td>
<td>-CONHCH<sub>2</sub>CH<sub>2</sub>WHAT<sub>2</sub>H,</td><td>-CONHCH<sub>2</sub>CH<sub>2</sub>CON<sub>2</sub> or CONH— / Ί j.</td>
(ix) a carboxyl group;
(x) an alkyl group substituted with a carboxyl group [eg, -CH<sub>2</sub>CH<sub>2</sub>WHAT<sub>2</sub>H];
(xi) heteroaryl [e.g.
<img file="SK9012002A3_D0003.tif" />
dyl group];
(xii) -C (= O) -R<sup>4</sup>where R<sup>4</sup> is an alkyl group [e.g., -C (= O) -CH<sub>3</sub>].
Particularly preferred are compounds of formula Ia wherein R @ 1<sup>10</sup> is an
H, C — CH, II —OCH<sub>3</sub>, —O — C — CH,
I CH<sub>2</sub>OH
H, C-CH, H, C-CH<sub>2</sub>
II II —O — C — CH, or —O — C — CH<sub>2</sub>
II co<sub>2</sub>h conh<sub>2</sub>
When p is 1, R is<sup>10</sup> it is suitably attached at position 5 of the indyl ring.
If p is a number 2, the groups are R<sup>10</sup> suitably attached at positions 6 of the indolyl ring.
A preferred group of compounds of the present invention are those compounds of formula Ia wherein:
R<sup>2</sup> is hydrogen;
R<sup>3</sup> is a hydrogen atom, an optionally substituted aryl group (for example a phenyl group) or a lower alkyl group (for example a methyl group), in particular a hydrogen atom;
X<sup>1</sup> is CH, C- (lower alkoxy) [especially C-OCH 3], C- (aryl) [especially C- (phenyl)], C- (halogen) [especially C-Cl] or C -CN;
R<sup>9</sup> is an:
(i) a hydrogen atom; (ii) a C 1 -C 4 alkyl group [e.g., -CH<sub>3</sub>(iii) a C 1-4 alkyl group substituted with a hydroxyl group [e.g. -CH<sub>2</sub>OH, -CH<sub>2</sub>CH<sub>2</sub>OH or -CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>(Iv) an alkyl group having from 1 to 4 carbon atoms substituted with an -N (R 6) group;<sup>5</sup>C (= O) -R<sup>7</sup> [e.g. -CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>NHC (= O) CH<sub>3</sub>(v) an alkyl group containing 1 to 4 carbon atoms substituted with a -C (= O) -NY group<sup>1</sup>Y<sup>2</sup> [for example —CH<sub>2</sub>—C (= O) —N0], or (vi) a cycloalkylalkyl group substituted with a hydroxyl group<sub>2</sub>C-CH<sub>2</sub> [e.g. —C — CH<sub>2</sub> ] ;
R<sup>10</sup> is an:
ch<sub>2</sub>oh (i) a hydroxyl group, (ii) a -OR group<sup>4</sup>where R<sup>4</sup> is an alkyl group [e.g. -OCH<sub>3</sub>(iii) -OR<sup>4</sup>where R<sup>4</sup> is an alkyl or cycloalkylalkyl group substituted with one or more hydroxyl groups [e.g. -OCH<sub>2</sub>CH<sub>2</sub>OH, -OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>OH, -OCH<sub>2</sub>CH (OH) CH<sub>2</sub>OH, -OCH<sub>2</sub>CH (OH) CH<sub>3</sub>, -OCH (CH<sub>3</sub>) CH<sub>2</sub>OH or h<sub>2</sub>C = CH<sub>2</sub>
II, -O-C-CH<sub>2</sub><sup>J</sup> 'ch<sub>2</sub>oh (iv) -OR<sup>4</sup>where R<sup>4</sup> is an alkyl group substituted with one or more alkoxy groups [e.g., -CH (CH<sub>3</sub>) CH<sub>2</sub>OCH<sub>3</sub>], (v) -OR<sup>4</sup>where R<sup>4</sup> is an alkyl or cycloalkyl group substituted with one or more carboxyl groups
H<sub>2</sub>C-CH<sub>2</sub> pins [e.g., -OCH<sub>2</sub>WHAT<sub>2</sub>H, -OCH (CH<sub>3</sub>) WHAT<sub>2</sub>H or -q-q-L];
I co<sub>2</sub>h (vi) -OR<sup>4</sup>where R<sup>4</sup> is cycloalkyl substituted with -C (= O) -NY<sup>1</sup>Y<sup>2</sup> [for example, or —O — C — CH<sub>2</sub>
I CONH<sub>2</sub>
H<sub>?</sub>C-CH<sub>?</sub> ii, —o — c — ch<sub>2</sub><sup>j</sup> 'conhch<sub>3</sub> (vii) the group -N (R 11);<sup>6</sup>) -C (= O) -R<sup>7</sup> [e.g. -NHC (= O) CH<sub>3</sub>] ;
(viii) -CONY group<sup>X</sup>Y<sup>2</sup> [e.g., -CONH<sub>2</sub>, -CONHCH<sub>3</sub>, -CONHCH (CH<sub>2</sub>OH) <sub>2</sub>, -CONHCH<sub>2</sub>CH<sub>2</sub>OH, -CONHC (CH<sub>3</sub>) <sub>2</sub>CH<sub>2</sub>OH, -CONHCH<sub>2</sub>CKD<sub>3</sub>,
-CONHCH<sub>2</sub>CH<sub>2</sub>WHAT<sub>2</sub>H, -CONHCH<sub>2</sub>CH<sub>2</sub>CON<sub>2</sub> or
<img file="SK9012002A3_D0004.tif" />
(ix) a carboxyl group, (x) an alkyl group substituted with a carboxyl group [e.g. -CH<sub>2</sub>CH<sub>2</sub>WHAT<sub>2</sub>H], (xi) heteroaryl [e.g.
<img file="SK9012002A3_D0005.tif" />
or pyridyl], (xii) -C (= O) -R<sup>4</sup>where R<sup>4</sup> is an alkyl group [e.g. -C (= O) -CH<sub>3</sub>], or (xii) a tetrazolyl group or an N-methyltetrazolyl group;
when p is 1, then R is<sup>10</sup> attached at the 5-position of the indolyl ring and when p is 2, then R is<sup>10</sup> attached at positions 5 and 6 of the indolyl ring;
and the corresponding N-oxides and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds, and N-oxides and prodrugs thereof.
Another preferred group of compounds of the present invention are those compounds of formula (Ia) wherein
R 'is hydrogen;
R<sup>J</sup> is hydrogen or lower alkyl (e.g. methyl), especially hydrogen;
X<sup>1</sup> is nitrogen;
R<sup>?</sup> is (i) a hydrogen atom, (ii) an alkyl group containing 1 to 4 carbon atoms [e.g. -CH<sub>3</sub>(iii) a C 1-4 alkyl group substituted with a hydroxyl group [e.g. -CH<sub>2</sub>OH, -CH<sub>2</sub>CH<sub>2</sub>OH or -CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>(Iv) an alkyl group having from 1 to 4 carbon atoms substituted with an -N (R 6) group;<sup>6</sup>C (= O) -R<sup>7</sup> [e.g., -CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>NH-C (= O) CH<sub>3</sub>(v) C 1-4 alkyl substituted by -C (= O) -NY<sup>1</sup>Y<sup>2</sup> [for example —CH<sub>2</sub>—C (= O) —N0], or (vi) a hydroxy-substituted cycloalkylalkyl group;
H<sub>2</sub>C-CH<sub>2</sub> pin [e.g. —C — CH<sub>2</sub>
CH<sub>2</sub>OH
<img file="SK9012002A3_D0006.tif" />
(i) a hydroxyl group, (ii) a -OR group<sup>4</sup>where R<sup>4</sup> is an alkyl group [e.g., -OCH 3], (iii) -OR<sup>4</sup>where R<sup>4</sup> is an alkyl or cycloalkylalkyl group substituted with one or more hydroxyl groups [e.g. -OCH<sub>2</sub>CH<sub>2</sub>OH, -OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>OH, -OCH<sub>2</sub>CH (OH) CH<sub>2</sub>OH, -OCH<sub>2</sub>CH (OH) CH<sub>3</sub>, -OCH (CH<sub>3</sub>) CH<sub>2</sub>OH or
H? C-CH?
II <sup>2</sup> .
-O-C-CH<sub>2</sub> J '
I ch<sub>2</sub>oh (iv) -OR<sup>4</sup>wherein R<sup>4</sup> is an alkyl group substituted with one or more alkoxy groups [e.g. -OCH (CH<sub>3</sub>(CH 2 OCH 3), (v) -OR<sup>4</sup>where R<sup>4</sup> is an alkyl or cycloalkyl group substituted with one or more carboxyl groups;
H, -CH<sub>2</sub>
II pins [e.g. -OCH<sub>2</sub>WHAT<sub>2</sub>H, -OCH (CH<sub>3</sub>) WHAT<sub>2</sub>H or __q_q_qh<sub>2</sub> ];
WHAT<sub>2</sub>H (vi) -OR<sup>4</sup>where R<sup>4</sup> is a cycloalkyl group substituted
-C (= O) -NY<sup>1</sup>Y<sup>2</sup> [e.g. CH<sub>2 and</sub>]_<sub>e</sub>b<sub>0</sub> O-C-CH,
I CONH<sub>2</sub>
H<sub>?</sub>C-cho
II 1 —0 — C — ch<sub>2</sub><sup>j</sup> ·
CONHCH<sub>3</sub> (vii) the group -N (R 11);<sup>6</sup>) -C (= O) -R<sup>7</sup> [e.g. -NHC (= O) CH<sub>3</sub>] ;
(viii) -CONYV group [e.g. -CONH<sub>2</sub>, -CONHCH 3, -CONHCH (CH<sub>2</sub>OH)<sub>2</sub>, -CONHCH 2 CH 2 OH, -CONHC (CH<sub>3</sub>)<sub>2</sub>CH<sub>2</sub>OH, -CONHCH<sub>2</sub>CHOCrt<sub>3</sub>,
-CONHCH<sub>2</sub>CH<sub>2</sub>WHAT<sub>2</sub>H, -CONHCH<sub>2</sub>CH<sub>2</sub>CON<sub>2</sub> or
<img file="SK9012002A3_D0007.tif" />
(ix) a carboxyl group, (x) an alkyl group substituted with a carboxyl group [e.g. -CH<sub>2</sub>CH<sub>2</sub>WHAT<sub>2</sub>H], (xi) heteroaryl [e.g.
<img file="SK9012002A3_D0008.tif" />
yl], (xii) -C (= O) -R<sup>4</sup>where R<sup>4</sup> is an alkyl group [e.g. -C (= O) -CH<sub>3</sub>], or (xii) a tetrazolyl group or an N-methyltetrazolyl group; when p is 1, then R is<sup>10</sup> attached at the 5-position of the indolyl ring and when p is 2, then R is<sup>10</sup> attached at positions 5 and 6 of the indolyl ring;
and the corresponding N-oxides and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds, and N-oxides and prodrugs thereof.
Another suitable group of compounds of the present invention are compounds of formula Ib:
<img file="SK9012002A3_D0009.tif" />
<img file="SK9012002A3_D0010.tif" />
<img file="SK9012002A3_D0011.tif" />
(Ib) wherein R<sup>2</sup>, R<sup>3</sup>, R<sup>9</sup>, R<sup>10</sup>, X<sup>1</sup> and p are as defined above and their prodrugs and pharmaceutically acceptable salts and solvates (e.g. hydrates) of the compounds of formula (Ib) and their prodrugs.
Preferred are compounds of formula Ib, wherein R is hydrogen.
Preference is given to compounds of the general formula Ib, in which R @ 1<sup>3</sup> is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), and especially hydrogen.
Preferred are compounds of formula Ib, wherein X<sup>1</sup> is CH, C-lower alkoxy (e.g. C-OCH<sub>3</sub>), C-aryl (for example C-phenyl), C-halogen (for example C-Cl), C-CN or nitrogen.
Preference is given to compounds of the general formula Ib, in which R @ 1<sup>9</sup> is a hydrogen atom.
Preferred are those compounds of formula (Ib) wherein R 1 is R 2<sup>9</sup> is an alkyl group having 1 to 4 carbon atoms [e.g. -CH 3].
Preferred are compounds of formula Ib, wherein 0 is.
A preferred group of compounds of the present invention are those compounds of formula (Ib) wherein
R<sup>2</sup> is hydrogen;
R<sup>3</sup> is a hydrogen atom, an optionally substituted aryl group (for example a phenyl group) or a lower alkyl group (for example a methyl group), in particular a hydrogen atom;
X<sup>1</sup> is CH, C- (lower alkoxy) [especially C-OCH 3], C-aryl [especially C-phenyl], C-halogen [especially C-Cl] or C-CN;
R<sup>9</sup> is hydrogen or (C1-C4) -alkyl [e.g. -CH3];
p is zero;
and the corresponding N-oxides and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of these compounds and their N-oxides and prodrugs.
Another preferred group of compounds of the present invention are those compounds of formula (Ib) wherein
R<sup>2</sup> is hydrogen;
R<sup>3</sup> is hydrogen or lower alkyl (e.g. methyl), especially hydrogen;
X<sup>1</sup> is nitrogen;
R<sup>9</sup> is a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms [e.g., -CH<sub>3</sub>] ;
p is zero;
and the corresponding N-oxides and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds, and N-oxides and prodrugs thereof.
Another group of suitable compounds of the present invention are compounds of formula Ic
<img file="SK9012002A3_D0012.tif" />
(Ic) where R<sup>2</sup>, R<sup>3</sup>, R<sup>9</sup>, R<sup>10</sup>, X<sup>1</sup> and p are as defined above, and prodrugs thereof and pharmaceutically acceptable salts and solvates (e.g., hydrates) of the compounds of formula (Ic) and prodrugs thereof.
Preference is given to compounds of the general formula Ic, wherein R is<sup>2</sup> is a hydrogen atom.
Preference is given to compounds of the general formula Ic, wherein R is<sup>3</sup> is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen.
Preferred are compounds of formula Ic wherein X<sup>1</sup> is CH, C- (lower alkoxy) (e.g. C-OCH 3), C- (aryl) (e.g. C-phenyl), C-halogen (e.g. C-Cl), C-CN or nitrogen atom.
Preference is also given to compounds of the general formula (Ic) in which R @ 1<sup>9</sup> is an alkyl group having 1 to 4 carbon atoms [e.g., -CH<sub>3</sub>] .
Preferred are compounds of formula Ic wherein p is 1.
Preference is given to compounds of the general formula Ic, wherein R is<sup>10</sup> is aryl [e.g., phenyl] and R<sup>10</sup> is suitably attached at position 4 of the pyrrole ring.
A preferred group of compounds of the present invention are those compounds of formula (Ic) wherein
R<sup>2</sup> is hydrogen;
R<sup>3</sup> is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen;
X<sup>1</sup> is CH, C- (lower alkoxy) [especially C-OCH 3], C- (aryl) [especially C-phenyl], C-halogen [especially C-Cl] or C-CN;
R<sup>9</sup> is (1-4C) alkyl [e.g., -CH 3];
P is 1;
R<sup>10</sup> is an aryl group [e.g., a phenyl group] and an aryl group
R<sup>10</sup> it is attached in position 4 of the pyrrole ring;
and the corresponding N-oxides, and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds, and N-oxides and prodrugs thereof.
Group R<sup>3</sup> is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen; group X<sup>1 </sup>is CH, C- (lower alkoxy) [especially C-OCH 3], C-aryl [especially C-phenyl], C-halogen [especially C-Cl] or C-CN.
Another preferred class of compounds of the present invention35
<td>lezu</td><td>They are</td><td>compounds of formula</td><td>Ic where</td>
<td>R<sup>2</sup></td><td>is an</td><td>a hydrogen atom;</td><td></td>
<td>R<sup>3</sup></td><td>is an</td><td>a hydrogen atom;</td><td></td>
<td>X<sup>1</sup></td><td>is an</td><td>a nitrogen atom;</td><td></td>
<td>R<sup>9</sup></td><td>is an</td><td>alkyl group containing</td><td>1-4 carbon atoms [e.g.</td>
<td></td><td colspan="2">clade -CH 3];</td><td></td>
<td>P</td><td>is an</td><td> 1;</td><td></td>
<td>R<sup>10</sup></td><td>is an</td><td>aryl group [e.g.</td><td>phenyl] and R 1<sup>10</sup> is an</td>
<td></td><td colspan="2">connected in position 4 pyrrole</td><td>ring;</td>
and the corresponding N-oxides, and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds, and N-oxides and prodrugs thereof.
Another suitable group of compounds of the present invention are compounds of formula Id:
<img file="SK9012002A3_D0013.tif" />
(R<sup>10</sup>)
<img file="SK9012002A3_D0014.tif" />
(Id) where R<sup>2</sup>, R<sup>3</sup>, R<sup>10</sup>, X<sup>1</sup> and p are as previously defined, and their prodrugs and pharmaceutically acceptable salts and solvates (e.g. hydrates) of the compound. and the prodrugs thereof.
Preferred are compounds of formula Id wherein
R<sup>2</sup> is hydrogen, lower alkyl (e.g. methyl), lower alkyl substituted by -CONY<sup>3</sup>Y<sup>4</sup> (e.g., -CH<sub>2</sub>CH<sub>2</sub>CONH2 or -CH2CH2CONHCH3), a lower alkyl group substituted with a carboxyl group (e.g., -CH2CH2CO2H), a lower alkyl group substituted with a tetrazolyl group [e.g.
<img file="SK9012002A3_D0015.tif" />
or a lower alkyl group substituted with a hydroxyl group [e.g., -CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>OH].
Preferred are compounds of formula 1d wherein R 1 is R 2<sup>3</sup> is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen.
Preferred are compounds of formula 1d wherein X<sup>1</sup> is CH, C- (lower alkoxy) (e.g. C-OCH<sub>3</sub>), C-aryl (for example C-phenyl), C-halogen (for example C-Cl), C-CN or nitrogen.
Preferred are compounds of formula 1d wherein p is 1.
Preferred are compounds of formula 1d wherein R 1 is R 2<sup>10</sup> is an alkyl group [e.g., tert-butyl group]. Group R<sup>10</sup> is suitably connected in position 4.
A preferred group of compounds of the present invention are those compounds of formula (Id) wherein:
R<sup>2</sup> is hydrogen, lower alkyl (e.g. methyl), lower alkyl substituted by -CONY<sup>3</sup>Y<sup>4</sup> (e.g., -CH<sub>2</sub>CH<sub>2</sub>CON<sub>2</sub> or -CH<sub>2</sub>CH<sub>2</sub>CONHCH<sub>3</sub>), a lower alkyl group substituted with a carboxyl group (e.g., an alkyl group substituted with a -CH<sub>2</sub>CH<sub>2</sub>WHAT<sub>2</sub>H), a different tetrazolyl group [to or lower alkyl group]
<img file="SK9012002A3_D0016.tif" />
to a substituted hydroxyl group [e.g.
CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>OH];
R<sup>3</sup> is a hydrogen atom, an optionally substituted aryl group (for example a phenyl group) or a lower alkyl group (for example a methyl group), in particular a hydrogen atom;
X<sup>1</sup> is CH, C- (lower alkoxy) [especially C-OCH 3], C-aryl [especially C-phenyl], C-halogen [especially C-Cl] or C-CN;
P is 1;
R<sup>10</sup> is an alkyl group [e.g., a tert-butyl group] and R 1<sup>10 </sup>it is connected in position 4;
and the corresponding N-oxides and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds, and N-oxides and prodrugs thereof.
Another preferred group of compounds of the present invention are those compounds of formula Id wherein
R<sup>2</sup> is hydrogen, lower alkyl (e.g. methyl), lower alkyl substituted by -CONY<sup>3</sup>Y<sup>1</sup>(e.g., -CH<sub>2</sub>CH<sub>2</sub>CON<sub>2</sub> or -CH<sub>2</sub>CH<sub>2</sub>CONHCH 3), a lower alkyl group substituted with a carboxyl group (e.g., -CH<sub>2</sub>CH<sub>2</sub>WHAT<sub>2</sub>H), a lower alkyl group substituted with a tetrazolyl group (na-
<img file="SK9012002A3_D0017.tif" />
] or a lower alkyl group substituted with a hydroxyl group [e.g., -CH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>OH];
R<sup>3</sup> is hydrogen;
X<sup>1</sup> is nitrogen;
p is 1;
R<sup>10</sup> is an alkyl group [e.g., a tert-butyl group] and R 1<sup>10 </sup>it is connected in position 4;
and the corresponding N-oxides and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds, and N-oxides and prodrugs thereof. '
Particular compounds of formula Ia of the present invention are selected from compounds formed by joining a carbon atom (C *) of one of the azaindole fragments (A 1 to A28) shown in Table 1 with a carbon atom (* C) of a five membered ring of one of the fragments (B 1 to B19) and coupling the carbon atom (C *) of the phenyl ring of one of the fragments (BI-B19) shown in Table 2 with an oxygen atom (* O) of one of the fragments (C1-C19) shown in Table 3.
Particular compounds of formula Ia of the present invention are selected from compounds formed by joining a carbon atom (C *) of one of the azaindole fragments (A 1 to A28) shown in Table 1 with a carbon atom (* C) of a five membered ring of one of the fragments (B 1 to B19) shown in Table 2, and by linking the carbon atom (C *) of the phenyl ring of one of the fragments (BI-B19) shown in Table 2 with the carbon atom (* C) of one of the fragments (C20-C44) shown in Table 3.
Particular compounds of formula Ia of the present invention are selected from compounds formed by joining a carbon atom (C *) of one of the azaindole fragments (A 1 to A28) shown in Table 1 with a carbon atom (* C) of a five membered ring of one of the fragments (B 1 to B19) shown in Table 2 and by joining the carbon atom (C *) of the phenyl ring of one of the fragments (BI-B19) shown in Table 2 with the nitrogen atom (* N) of the fragment (C45) or hydrogen (* H, fragment (C46)) in Table 3.
Particular compounds of formula Ib according to the present invention are selected from compounds formed by joining a carbon atom (C *) of one of the azaindole fragments (A1 to A28) listed in Table 1 with a carbon atom (* C) in a five membered ring of one of the indolizine fragments (B20). or B21) listed in Table 2 and by joining a carbon (C *) atom in a six membered ring of one of the indolizine fragments (B20 or B21) listed in Table 2 with (i) an oxygen atom (* 0) of one of the fragments (C1 to C19), (ii) a carbon atom (* C) of one of the fragments (C20 to C42), (iii) a nitrogen atom (* N) of fragment (C45), or (iv) a hydrogen atom (* H, fragment (C46)) listed in Table 3.
Particular compounds of the present invention of formula (1b) are also selected from compounds formed by joining the carbon atom (C *) of one of the azaindole fragments (A1 to A28) listed in Table 1 with the carbon atom (* C) of the indolizine fragment (B22) shown in Table 2 .
Particular compounds of the present invention of formula Ic are selected from compounds formed by combining the carbon atom (C *) of one of the azaindole fragments (A 1 to A28) listed in Table 1 with a carbon atom (* C) of one of the pyrrole fragments (B23 to B32) in Table 2.
Particular compounds of the present invention of general formula Id are selected from compounds formed by joining a carbon atom (C *) of one of the azaindole fragments (A29 to A41) shown in Table 1 with a carbon atom (* C) of one of the fragments (B33 to B44) Table 2.
Table 1
<img file="SK9012002A3_D0018.tif" />
<img file="SK9012002A3_D0019.tif" />
<img file="SK9012002A3_D0020.tif" />
<img file="SK9012002A3_D0021.tif" />
Table 2
<td>BI</td><td>R - C * N, N \ ch<sub>3</sub></td><td>B2</td><td>* Cr \ __ / \ H</td>
<td>B3</td><td>.— C *</td><td>B4</td><td>C *</td>
<td></td><td>j!</td><td></td><td>J /</td>
<td></td><td> *<sup>C</sup>'\<sub>sr =</sub>y</td><td></td><td>* C \ __ /</td>
<td></td><td>'N</td><td></td><td>in</td>
<td></td><td> \</td><td></td><td> \</td>
<td></td><td>ch<sub>2</sub>ch<sub>3</sub></td><td></td><td>ch<sub>2</sub>oh</td>
<td>B5</td><td>R *</td><td>B6</td><td>c *</td>
<td></td><td>j</td><td></td><td>J / X \</td>
<td></td><td>Q</td><td></td><td></td>
<td></td><td></td><td></td><td></td>
<td></td><td> \</td><td></td><td> \</td>
<td></td><td>ch<sub>2</sub>ch<sub>2</sub>oh</td><td></td><td>ch<sub>2</sub>ch<sub>2</sub>ch<sub>2</sub>oh</td>
<td>B7</td><td></td><td>B8</td><td>.-A *</td>
<td></td><td></td><td></td><td>J / X</td>
<td></td><td></td><td></td><td>* C ^ \ /</td>
<td></td><td>/ C *</td><td></td><td></td>
<td></td><td></td><td></td><td></td>
<td></td><td></td><td></td><td> \</td>
<td></td><td></td><td></td><td>CH,</td>
<td></td><td>u / N \</td><td></td><td></td>
<td></td><td>ch<sub>2</sub>ch<sub>2</sub>ch<sub>2</sub>NHCOCH<sub>3</sub></td><td></td><td>n</td>
<td></td><td></td><td></td><td>m</td>
<td>B9</td><td></td><td>B10</td><td>/ - C *</td>
<td></td><td>c *</td><td></td><td>FŽ</td>
<td></td><td></td><td></td><td></td>
<td></td><td></td><td></td><td>t / N \</td>
<td></td><td>N</td><td></td><td>CH.</td>
<td></td><td>\ CH, O 2 z</td><td></td><td>'r about</td>
<td></td><td>NH,</td><td></td><td>í \</td>
<td></td><td></td><td></td><td>OH</td>
<td></td><td></td><td></td><td>^ OH</td>
<td>Bil</td><td><sup>C</sup>* N \<sup>CH</sup>2 ° = < N -<sub>H </sub>C - OH</td><td>B12</td><td>• tp</td>
<td>B13</td><td>r ~<sup>Q</sup>* ^ CH ^ _3<sub>2</sub>OH</td><td>B14</td><td>I-<sup>C</sup>* * C ^ \ __./ \ OH Á</td>
<td>B15</td><td>/ C * * C \ __ / gB<sup>C1</sup> \</td><td>B16</td><td>, C * \ ch<sub>3</sub></td>
<td>B17</td><td>\ H</td><td>B18</td><td>A * \ ch<sub>3</sub></td>
<td>B19</td><td>TV \ * 'íTV<sup>7</sup>\ H</td><td>B20</td><td>A ^<sup>C</sup>* * cX J | ^ /<sup>N</sup>—</td>
<img file="SK9012002A3_D0022.tif" />
<td>B31</td><td>ý ' 'N '1</td><td>B32</td><td>JJ 'U \</td>
<td>B33</td><td>F ~ \ _ * C 7 — CMe<sub>q</sub> \=/</td><td>B34</td><td></td>
<td>B35</td><td> -77</td><td>B36</td><td> -77</td>
<td>B37</td><td>7 \ Γ ~ \ ★ C \ / —N \ __ / 0</td><td>B38</td><td></td>
<td>B39</td><td>/ * C 7 - N \ = / \</td><td>B40</td><td>ABOUT\</td>
<td>B41</td><td>* c 7 — o</td><td>B42</td><td>* C 7 — C ~ N</td>
<td>B43</td><td> *<sup>C</sup>YPA</td><td>B44</td><td>/ - OH 0- ' H * Q - - Q \ = J \</td>
Table 3
<td>Cl</td><td>* O-ch<sub>3</sub></td><td>C2</td><td>HO</td><td> — 0</td>
<td>C3</td><td>/ - OH * 0- '</td><td>C4</td><td> *0—'</td><td>OH</td>
<img file="SK9012002A3_D0023.tif" />
<td>C27</td><td>WITH ABOUT about /-' II / * C-NH</td><td>C28</td><td>0 II * C — OH</td>
<td>C29</td><td>0 II * C-NH<sub>2</sub></td><td>C30</td><td>0 II * c - NH HO-- '' OH</td>
<td>C31</td><td>0 II * C-NH λλ.</td><td>C32</td><td>0 II ★ C — NH The HO OH</td>
<td>C33</td><td>0 II * C — NH J-Λ HO-- 'OH</td><td>C34</td><td>0 II * C-NH-CH<sub>2</sub>CH<sub>2</sub>OH</td>
<td>C35</td><td> /<sup>N</sup>< * CN W / N — N \</td><td>C36</td><td>H * c N WHN-N</td>
<td>C37</td><td></td><td>C38</td><td> /<sup>N</sup>\ * C ABOUT</td>
<td>C39</td><td>* C<sup>A</sup>NM</td><td>C40</td><td>of x ° *<sup>C</sup>\\ J <sup>N</sup> \ ..</td>
<td>C41</td><td>* CH-NH-SO<sub>2</sub>CH<sub>3</sub></td><td>C42</td><td>ch<sub>3</sub>* C ~ OH 1 ch<sub>3</sub></td>
<td>C43</td><td>H 1 * C-OH 1 ch<sub>3</sub></td><td>C44</td><td>ch *<sub>2</sub>NH-CO-NHCH<sub>2</sub>ch<sub>3</sub></td>
<td>C45</td><td>* NH- 0</td><td>C46</td><td>H</td>
Particularly preferred examples of fragments "A," B, and "C" are set forth in the description below:
A1-B1-C1;
A1-B1-C7;
A1-B1-C13;
A1-B1-C19;
A1-B1-C25;
A1-B1-C31;
A1-B1-C37;
A1-B1-C43;
A2-B1-C3;
A2-B1-C9;
A2-B1-C15;
A2-B1-C21;
A2-B1-C27;
A2-B1-C33;
A2-B1-C39;
A2-B1-C45;
A3-B1-C5;
A3-B1-C11;
A3-B1-C17;
A3-B1-C23;
A3-B1-C29;
A3-B1-C35;
A3-B1-C41;
A4-B1-C1;
A4-B1-C7;
A4-B1-C13;
A4-B1-C19;
A4-B1-C25;
A4-B1-C31;
A4-B1-C37;
A4-B1-C43;
A5-B1-C3;
A5-B1-C9;
A5-B1-C15;
A5-B1-C21;
A5-B1-C27;
A5-B1-C33;
A5-B1-C39;
A5-BI-C45;
A6-B1-C5;
A6-B1-C11;
A6-B1-C17;
A6-B1-C23;
A6-B1-C29;
A6-B1-C35;
A6-B1-C41;
A7-B1-C1;
A7-B1-C7;
A7-B1-C13;
A7-B1-C19;
A7-B1-C25;
A7-B1-C31;
A7-B1-C37;
A7-B1-C43;
A8-B1-C3;
A8-B1-C9;
A8-B1-C15;
A8-B1-C21;
A1-B1-C2;
A1-B1-C8;
A1-B1-C14;
A1-B1-C20;
A1-B1-C26;
A1-B1-C32;
A1-B1-C38;
A1-B1-C44; A2-B1-C4;
A2-B1-C10;
A2-B1-C16;
A2-B1-C22;
A2-B1-C28;
A2-B1-C34;
A2-B1-C40;
A2-B1-C46;
A3-B1-C6;
A3-B1-C12;
A3-B1-C18;
A3-B1-C24;
A3-B1-C30;
A3-B1-C36;
A3-B1-C42;
A4-B1-C2;
A4-B1-C8;
A4-B1-C14;
A4-B1-C20;
A4-B1-C26;
A4-B1-C32;
A4-B1-C38;
A4-B1-C44;
A5-B1-C4;
A5-B1-C10;
A5-B1-C16;
A5-B1-C22;
A5-B1-C28;
A5-B1-C34;
A5-B1-C40;
A5-B1-C46;
A6-B1-C6;
A6-B1-C12;
A6-B1-C18;
A6-B1-C24;
A6-B1-C30;
A6-B1-C36;
A6-B1-C42;
A7-B1-C2;
A7-B1-C8;
A7-B1-C14;
A7-B1-C20;
A7-B1-C26;
A7-B1-C32;
A7-B1-C38;
A7-B1-C44;
A8-B1-C4;
A8-B1-C10;
A8-B1-C16;
A8-B1-C22;
A1-B1-C3;
A1-B1-C9;
A1-B1-C15;
A1-B1-C21;
A1-B1-C27;
A1-B1-C33;
A1-B1-C39;
A1-B1-C45;
A2-B1-C5;
A2-B1-C11;
A2-B1-C17;
A2-B1-C23;
A2-B1-C29;
A2-B1-C35;
A2-B1-C41;
A3-B1-C1;
A3-B1-C7;
A3-B1-C13;
A3-B1-C19;
A3-B1-C25;
A3-B1-C31;
A3-B1-C37;
A3-B1-C43;
A4-B1-C3;
A4-B1-C9;
A4-B1-C15;
A4-B1-C21;
A4-B1-C27;
A4-B1-C33;
A4-B1-C39;
A4-B1-C45; A5-B1-C5; .
A5-B1-C11;
A5-B1-C17;
A5-B1-C23;
A5-B1-C29;
A5-B1-C35;
A5-B1-C41;
A6-B1-C1;
A6-B1-C7;
A6-B1-C13;
A6-B1-C19;
A6-B1-C25;
A6-B1-C31;
A6-B1-C37;
A6-B1-C43;
A7-B1-C3;
A7-B1-C9;
A7-B1-C15;
A7-B1-C21;
A7-B1-C27;
A7-B1-C33;
A7-B1-C39;
A7-B1-C45;
A8-B1-C5;
A8-B1-C11;
A8-B1-C17;
A8-B1-C23;
A1-B1-C4;
A1-B1-C10;
A1-B1-C16;
A1-B1-C22;
A1-B1-C28;
A1-B1-C34;
A1-B1-C40;
A1-B1-C46;
A2-B1-C6;
A2-B1-C12;
A2-B1-C18;
A2-B1-C24;
A2-B1-C30;
A2-B1-C36;
A2-B1-C42;
A3-B1-C2;
A3-B1-C8;
A3-B1-C14;
A3-B1-C20;
A3-B1-C26;
A3-B1-C32;
A3-B1-C38;
A3-B1-C44;
A4-B1-C4;
A4-B1-C10;
A4-B1-C16;
A4-B1-C22;
A4-B1-C28;
A4-B1-C34;
A4-B1-C40;
A4-B1-C46;
A5-B1-C6;
A5-B1-C12;
A5-B1-C18;
A5-B1-C24;
A5-B1-C30;
A5-B1-C36;
A5-B1-C42;
A6-B1-C2;
A6-B1-C8;
A6-B1-C14;
A6-B1-C20;
A6-B1-C26;
A6-B1-C32;
A6-B1-C38;
A6-B1-C44;
A7-B1-C4;
A7-B1-C10;
A7-B1-C1S;
A7-B1-C22;
A7-B1-C28;
A7-B1-C34;
A7-B1-C40;
A7-B1-C46;
A8-B1-C6;
A8-B1-C12;
A8-B1-C18;
A8-B1-C24;
A1-B1-C5;
A1-B1-C11;
A1-B1-C17;
A1-B1-C23;
A1-B1-C29;
A1-B1-C35;
A1-B1-C41;
A2-B1-C1;
A2-B1-C7;
A2-B1-C13;
A2-B1-C19;
A2-B1-C25;
A2-B1-C31;
A2-B1-C37;
A2-B1-C43;
A3-B1-C3;
A3-B1-C9;
A3-B1-C15;
A3-B1-C21;
A3-B1-C27;
A3-B1-C33;
A3-B1-C39;
A3-B1-C45; A4-B1-C5;
A4-B1-C11;
A4-B1-C17;
A4-B1-C23;
A4-B1-C29;
A4-B1-C35;
A4-B1-C41;
A5-B1-C1;
A5-B1-C7;
A5-B1-C13;
A5-B1-C19;
A5-B1-C25;
A5-B1-C31;
A5-B1-C37;
A5-B1-C43;
A6-B1-C3;
A6-B1-C9;
A6-B1-C15;
A6-B1-C21;
A6-B1-C27;
A6-B1-C33;
A6-B1-C39;
A6-B1-C45;
A7-B1-C5;
A7-B1-C1I;
A7-B1-C17;
A7-B1-C23;
A7-B1-C29;
A7-B1-C35;
A7-B1-C41;
A8-B1-C1;
A8-B1-C7;
A8-B1-C13;
A8-B1-C19;
A8-B1-C25;
A1-B1-C6;
A1-B1-C12;
A1-B1-C18;
A1-B1-C24;
A1-B1-C30;
A1-B1-C36;
A1-B1-C42;
A2-B1-C2;
A2-B1-C8;
A2-B1-C14;
A2-B1-C20;
A2-B1-C26;
A2-B1-C32;
A2-B1-C38;
A2-B1-C44;
A3-B1-C4;
A3-B1-C10;
A3-B1-C16;
A3-B1-C22;
A3-B1-C28;
A3-B1-C34;
A3-B1-C40;
A3-B1-C46; A4-B1-C6;
A4-B1-C12;
A4-B1-C18;
A4-B1-C24;
A4-B1-C30;
A4-B1-C36;
A4-B1-C42;
A5-B1-C2;
A5-B1-C8;
A5-B1-C14;
A5-B1-C20;
A5-31-C26;
A5-B1-C32;
A5-B1-C38;
A5-B1-C44; A6-31-C4;
A6-B1-C10;
A6-B1-C16;
A6-B1-C22;
A6-B1-C28;
A6-B1-C34;
A6-B1-C40;
A6-B1-C46;
A7-B1-C6;
A7-B1-C12;
A7-B1-C18;
A7-B1-C24;
A7-B1-C30;
A7-B1-C36;
A7-B1-C42;
A8-B1-C2;
A8-B1-C8;
A8-B1-C14;
A8-B1-C20;
A8-B1-C26;
A8-B1-C27;
A8-B1-C33;
A8-B1-C39;
A8-B1-C45;
A9-B1-C5;
A9-B1-C11;
A9-B1-C17;
A9-B1-C23;
A9-B1-C29;
A9-B1-C35;
A9-B1-C41;
A10-B1-C1;
A10-B1-C7;
A10-B1-C13;
A10-B1-C19;
A10-B1-C25;
A10-B1-C31;
A10-B1-C37;
A10-B1-C43;
A11-B1-C3;
A11-B1-C9;
A11-B1-C15;
A11-B1-C21;
A11-B1-C27;
A11-B1-C33;
A11-B1-C39;
A11-B1-C45; A12-B1-C5;
A12-B1-C11;
A12-B1-C17;
A12-B1-C23;
A12-B1-C29;
A12-B1-C35;
A12-B1-C41;
A13-B1-C1;
A13-B1-C7;
A13-B1-C13;
A13-B1-C19;
A13-B1-C25;
A13-B1-C31;
A13-B1-C37;
A13-B1-C43;
A14-B1-C3;
A14-B1-C9;
A14-B1-C15;
A14-B1-C21;
A14-B1-C27;
A14-B1-C33;
A14-B1-C39;
A14-B1-C45;
A15-B1-C5;
A15-B1-C11;
A15-B1-C17;
A15-B1-C23;
A15-B1-C29;
A15-B1-C35;
A15-B1-C41;
A16-B1-C1;
A16-B1-C7;
A16-B1-C13;
A16-B1-C19;
A16-B1-C25;
A16-B1-C31;
A8-B1-C28;
A8-B1-C34;
A8-B1-C4O;
A8-B1-C46;
A9-B1-C6;
A9-B1-C12;
A9-B1-C18;
A9-B1-C24;
A9-B1-C30;
A9-B1-C36;
A9-B1-C42;
A10-B1-C2;
A10-B1-C8;
A10-B1-C14;
A10-B1-C20;
A10-B1-C26;
A10-B1-C32;
A10-B1-C38;
A1O-B1-C44;
A11-B1-C4;
A11-B1-C1O;
A11-B1-C16;
A11-B1-C22;
A11-B1-C28;
A11-B1-C34;
A11-B1-C40;
A11-B1-C46;
A12-B1-C6;
A12-B1-C12;
A12-B1-C18;
A12-B1-C24
A12-B1-C30;
A12-B1-C36;
A12-B1-C42;
A13-B1-C2;
A13-B1-C8;
A13-B1-C14;
A13-B1-C2O;
A13-B1-C26;
A13-B1-C32;
A13-B1-C38;
A13-B1-C44;
A14-B1-C4;
A14-B1-C1O;
A14-B1-C16;
A14-B1-C22;
A14-B1-C28;
A14-B1-C34-;
A14-B1-C4O;
A14-B1-C46;
A15-B1-C6;
A15-B1-C12;
A15-B1-C18;
A15-B1-C24;
A15-B1-C3o;
A15-B1-C36;
A15-B1-C42;
A16-B1-C2;
A16-B1-C8;
A16-B1-C14;
A16-B1-C20;
A16-B1-C26;
A16-B1-C32;
A8-B1-C29;
A8-B1-C35;
A8-B1-C41;
A9-B1-C1;
A9-B1-C7;
A9-B1-C13;
A9-B1-C19;
A9-B1-C25;
A9-B1-C31;
A9-B1-C37;
A9-B1-C43;
A10-B1-C3;
A10-B1-C9;
A10-B1-C15;
A10-B1-C21;
A10-B1-C27;
A10-B1-C33;
A10-B1-C39;
A1O-B1-C45;
A1i-B1-C5;
A11-B1-C11;
A11-B1-C17;
A11-B1-C23;
A11-B1-C29;
A11-B1-C35;
A11-B1-C41;
A12-B1-C1;
A12-B1-C7;
A12-B1-C13;
A12-B1-C19;
A12-B1-C25;
A12-B1-C31;
A12-B1-C37;
A12-B1-C43;
A13-B1-C3;
A13-B1-C9;
A13-B1-C15;
A13-B1-C21;
A13-B1-C27;
A13-B1-C33;
A13-B1-C39;
A13-B1-C45;
A14-B1-C5;
A14-B1-C11;
A14-B1-C17;
A14-B1-C23;
A14-B1-C29;
A14-B1-C35;
A14-B1-C41;
A15-B1-C1;
A15-B1-C7;
A15-B1-C13;
A15-B1-C19;
A15-B1-C25;
A15-B1-C31;
A15-B1-C37;
A15-B1-C43;
A16-B1-C3;
A16-B1-C9;
A16-B1-C15;
A16-B1-C21;
A16-B1-C27;
A16-B1-C33;
A8-B1-C3o;
A8-B1-C36;
A8-B1-C42;
A9-B1-C2;
A9-B1-C8;
A9-B1-C14;
A9-B1-C20;
A9-B1-C26;
A9-B1-C32;
A9-B1-C38;
A9-B1-C44;
A1O-B1-C4;
A10-B1-C10;
A10-B1-C16;
A10-B1-C22;
A10-B1-C28;
A10-B1-C34;
A10-B1-C40;
A1O-B1-C46;
A11-B1-C6;
A11-B1-C12;
A11-B1-C18;
A11-B1-C24;
A11-B1-C30;
A11-B1-C36;
A11-B1-C42;
A12-B1-C2;
A12-B1-C8;
A12-B1-C14;
A12-B1-C20;
A12-B1-C26;
A12-B1-C32;
A12-B1-C38;
A12-B1-C44;
A13-B1-C4;
A13-B1-C1O;
A13-B1-C16;
A13-B1-C22;
A13-B1-C28;
A13-B1-C34;
A13-B1-C4O;
A13-B1-C46; A14-B1-C6;
A14-B1-C12;
A14-B1-C18;
A14-B1-C24;
A14-B1-C3o;
A14-B1-C36;
A14-B1-C42;
A15-B1-C2;
A15-B1-C8;
A15-B1-C14;
A15-B1-C20;
A15-B1-C26;
A15-B1-C32;
A15-B1-C38;
A15-B1-C44;
A16-B1-C4;
A16-B1-C10;
A16-B1-C16;
A16-B1-C22;
A16-B1-C28;
A16-B1-C34;
A8-B1-C31;
A8-B1-C37;
A8-B1-C43;
A9-B1-C3;
A9-B1-C9;
A9-B1-C15;
A9-B1-C21;
A9-B1-C27;
A9-B1-C33;
A9-B1-C39;
A9-B1-C45;
A10-B1-C5;
A1O-B1-C11;
A10-B1-C17;
A10-B1-C23;
A10-B1-C29;
A10-B1-C35;
A1O-B1-C41;
A11-B1-C1;
A11-B1-C7;
A11-B1-C13;
A11-B1-C19;
A11-B1-C25;
A11-B1-C31;
A11-B1-C37;
A11-B1-C43;
A12-B1-C3;
A12-B1-C9;
A12-B1-C15; A12-B1-C21;
A12-B1-C27;
A12-B1-C33;
A12-B1-C39;
A12-B1-C45;
A13-B1-C5;
A13-B1-C11;
A13-B1-C17;
A13-B1-C23;
A13-B1-C29;
A13-B1-C35; A13-B1-C41;
A14-B1-C1;
A14-B1-C7;
A14-B1-C13;
A14-B1-C19;
A14-B1-C25;
A14-B1-C31;
A14-B1-C37;
A14-B1-C43;
A15-B1-C3;
A15-B1-C9;
A15-B1-C15;
A15-B1-C21;
A15-B1-C27;
A15-B1-C33;
A15-B1-C39;
A15-B1-C45;
A16-B1-C5;
A16-B1-C11;
A16-B1-C17;
A16-B1-C23;
A16-BI-C29;
A16-B1-C35;
A8-B1-C32;
A8-B1-C38;
A8-B1-C44;
A9-B1-C4;
A9-B1-C10;
A9-B1-C16;
A9-B1-C22;
A9-B1-C28;
A9-B1-C34;
A9-B1-C40;
A9-B1-C46;
A1O-B1-C6;
A10-B1-C12;
A10-B1-C18;
A10-B1-C24;
A10-B1-C30;
A10-B1-C36;
A10-B1-C42;
A11-B1-C2;
A11-B1-C8;
A11-B1-C14;
A11-B1-C2O;
A11-B1-C26;
A11-B1-C32;
A11-B1-C38;
A11-B1-C44;
A12-B1-C4;
A12-B1-C10;
A12-B1-C16;
A12-B1-C22;
A12-B1-C28;
A12-B1-C34;
A12-B1-C4O;
A12-B1-C46;
A13-B1-C6;
A13-B1-C12;
A13-B1-C18;
A13-B1-C24;
A13-B1-C3o;
A13-B1-C36;
A13-B1-C42;
A14-B1-C2;
A14-B1-C8;
A14-B1-C14;
A14-B1-C20;
A14-B1-C26;
A14-B1-C32;
A14-B1-C38;
A14-B1-C44;
A15-B1-C4;
A15-B1-C10;
A15-B1-C16;
A15-B1-C22;
A15-B1-C28; A15-B1-C34; A15-B1-C40; A15-B1-C46;
A16-B1-C6;
A16-B1-C12;
A16-B1-C18;
A16-B1-C24;
A16-B1-C30;
A16-B1-C36;
A16-B1-C37; A16-B1-C43; A17-B1-C3;
A17-B1-C9;
A17-B1-C15;
A17-B1-C21;
A17-B1-C27;
A17-B1-C33;
A17-B1-C39;
A17-B1-C45; A18-B1-C5;
A18-B1-C11;
A18-B1-C17;
A18-B1-C23;
A18-B1-C29;
A18-B1-C35;
A18-B1-C41;
A19-B1-C1;
A19-B1-C7;
A19-B1-C13;
A19-B1-C19;
A19-B1-C25;
A19-B1-C31;
A19-B1-C37;
A19-B1-C43;
A20-B1-C3;
A20-B1-C9;
A20-B1-C15;
A20-B1-C21;
A20-B1-C27;
A20-B1-C33;
A20-B1-C39;
A20-B1-C45;
A21-B1-C5;
A21-B1-C11;
A21-B1-C17;
A21-B1-C23;
A21-B1-C29;
A21-B1-C35;
A21-B1-C41; A22-B1-C1;
A22-B1-C7;
A22-B1-C13;
A22-B1-C19;
A22-B1-C25;
A22-B1-C31;
A22-B1-C37;
A22-B1-C43;
A23-B1-C3;
A23-B1-C9;
A23-B1-C15;
A23-B1-C21;
A23-B1-C27;
A23-B1-C33;
A23-B1-C39;
A23-B1-C45; A24-B1-C5;
A24-B1-C11;
A24-B1-C17;
A24-B1-C23;
A24-B1-C29;
A24-B1-C35;
A24-B1-C41;
A16-B1-C38; A16-B1-C44; A17-B1-C4;
A17-B1-C10;
A17-B1-C16;
A17-B1-C22;
A17-B1-C28; A17-B1-C34; A17-B1-C40;
A17-B1-C46;
A18-B1-C6;
A18-B1-C12;
A18-B1-C18; A18-B1-C24; A18-B1-C30;
A18-B1-C36;
A18-B1-C42;
A19-B1-C2;
A19-B1-C8;
A19-B1-C14;
A19-B1-C20;
A19-B1-C26; AL9-B1-C32; A19-B1-C38; A19-B1-C44; A20-B1-C4;
A20-B1-C10;
A20-B1-C16;
A20-B1-C22;
A20-B1-C28;
A20-B1-C34;
A20-B1-C40;
B1-A20-C46;
A21-B1-C6;
A21-B1-C12;
A21-B1-C18;
A21-B1-C24;
A21-B1-C30;
A21-B1-C36;
A21 B1-C42;
A22-B1-C2;
A22-B1-C8;
A22-B1-C14;
A22-B1-C20;
A22-B1-C26;
A22-B1-C32;
A22-B1-C38;
A22-B1-C44 ·;
A23-B1-C4;
A23-B1-C10;
A23-B1-C16;
A23-B1-C22;
A23-B1-C28;
A23-B1-C34;
A23-B1-C40;
A23-B1-C4S;
A24-B1-C6;
A24-B1-C12;
A24-B1-C18;
A24-B1-C24;
A24-B1-C30;
A24-B1-C36;
A24-B1-C42;
A16-B1-C39;
A16-B1-C45;
A17-B1-C5;
A17-B1-C11;
A17-B1-C17;
A17-B1-C23;
A17-B1-C29;
A17-B1-C35;
A17-B1-C41;
A18-B1-C1;
A18-B1-C7;
A18-B1-C13;
A18-B1-C19;
A18-B1-C25;
A18-B1-C31;
A18-B1-C37;
A18-B1-C43;
A19-B1-C3;
A19-B1-C9;
A19-B1-C15;
A19-B1-C21;
A19-B1-C27;
A19-B1-C33;
A19-B1-C39;
A19-B1-C45;
A20-B1-C5;
A20-B1-C11;
A20-B1-C17;
A20-B1-C23;
A20-B1-C29;
A20-B1-C35;
A20-B1-C41;
A21-B1-C1;
A21-B1-C7;
A21-B1-C13;
A21-B1-C19;
A21-B1-C25;
A21-B1-C31;
A21-B1-C37;
A21-B1-C43;
A22-B1-C3;
A22-B1-C9;
A22-B1-C15;
A22-B1-C21;
A22-B1-C27;
A22-B1-C33;
A22-B1-C39;
A22-B1-C45;
A23-B1-C5;
A23-B1-C11;
A23-B1-C17;
A23-B1-C23;
A23-B1-C29;
A23-B1-C35;
A23-B1-C41;
A24-B1-C1;
A24-B1-C7;
A24-B1-C13;
A24-B1-C19;
A24-B1-C25;
A24-B1-C31;
A24-B1-C37;
A24-B1-C43;
A16-B1-C40;
A16-B1-C46;
A17-B1-C6;
A17-B1-C12;
A17-B1-C18;
A17-B1-C24;
A17-B1-C30;
A17-B1-C36;
A17-B1-C42;
A18-B1-C2; '
A18-B1-C8;
A18-B1-C14;
A18-B1-C20;
A18-B1-C26;
A18-B1-C32;
A18-B1-C38;
A18-B1-C44;
A19-B1-C4;
A19-B1-C10;
A19-B1-C16;
A19-B1-C22;
A19-B1-C28;
A19-B1-C34;
A19-B1-C40;
A19-B1-C46;
A20-B1-C6;
A20-B1-C12;
A20-B1-C18;
A20-B1-C24;
A20-B1-C30;
A20-B1-C36;
A20-B1-C42;
A21-B1-C2;
A21-B1-C8;
A21-B1-C14;
A21-B1-C20;
A21-B1-C26;
A21-B1-C32;
A21-B1-C38;
A21-B1-C44;
A22-B1-C4;
A22-B1-C10;
A22-B1-C16;
A22-B1-C22;
A22-B1-C28;
A22-B1-C34;
A22-B1-C40;
A22-B1-C46;
A23-B1-C6;
A23-B1-C12;
A23-B1-C18;
A23-B1-C24;
A23-B1-C30;
A23-B1-C36;
A23-B1-C42;
A24-B1-C2;
A24-B1-C8;
A24-B1-C14;
A24-B1-C20;
A24-B1-C26;
A24-B1-C32;
A24-B1-C38;
A24-B1-C44;
A16-B1-C41;
A17-B1-C1;
A17-B1-C7;
A17-B1-C13;
A17-B1-C19;
A17-B1-C25;
A17-B1-C31;
A17-B1-C37;
A17-B1-C43;
A18-B1-C3;
A18-B1-C9;
A18-B1-C15;
A18-B1-C21;
A18-B1-C27;
A18-B1-C33;
A18-B1-C39;
A18-B1-C45;
A19-B1-C5;
A19-B1-C11;
A19-B1-C17;
A19-B1-C23;
A19-B1-C29;
A19-B1-C35;
A19-B1-C41;
A20-B1-C1;
A20-B1-C7;
A20-B1-C13;
A20-B1-C19;
A20-B1-C25;
A20-B1-C31;
A20-B1-C37;
A20-B1-C43;
A21-B1-C3;
A21-B1-C9;
A21-B1-C15;
A21-B1-C21;
A21-B1-C27;
A21-B1-C33;
A21-B1-C39;
A21-B1-C45;
A22-B1-C5;
A22-B1-C11;
A22-B1-C17;
A22-B1-C23;
A22-B1-C29;
A22-B1-C35;
A22-B1-C41;
A23-B1-C1;
A23-B1-C7;
A23-B1-C13;
A23-B1-C19;
A23-B1-C25;
A23-B1-C31;
A23-B1-C37;
A23-B1-C43;
A24-B1-C3;
A24-B1-C9;
A24-B1-C15;
A24-B1-C21;
A24-B1-C27;
A24-B1-C33;
A24-B1-C39;
A24-B1-C45;
A16-B1-C42;
A17-B1-C2;
A17-B1-C8;
A17-B1-C14;
A17-B1-C20;
A17-B1-C26;
A17-B1-C32;
A17-B1-C38;
A17-B1-C44;
A18-B1-C4;
A18-B1-C10;
A18-B1-C16;
A18-31-C22;
A18-31-C28;
A18-31-C34;
A18-B1-C40;
A18-31-C46;
A19-31-C6;
A19-B1-C12;
A19-B1-C18;
A19-B1-C24;
A19-B1-C30;
A19-B1-C36;
A19-B1-C42;
A20-B1-C2;
A20-B1-C8;
A20-B1-C14;
A20-B1-C20;
A20-B1-C26;
A20-B1-C32;
A20-B1-C38;
A20-B1-C44; A21-31-C4;
A21-31-C10;
A21-31-C16;
A21-B1-C22;
A21-B1-C28;
A21-B1-C34;
A21-B1-C40;
A21-B1-C46;
A22-B1-C6;
A22-B1-C12;
A22-B1-C18;
A22-B1-C24;
A22-B1-C30;
A22-B1-C36;
A22-B1-C42;
A23-31-C2;
A23-B1-C8;
A23-B1-C14;
A23-B1-C20;
A23-B1-C26;
A23-B1-C32;
A23-B1-C38;
A23-31-C44; A24-B1-C4;
A24-B1-C10;
A24-B1-C16;
A24-31-C22;
A24-B1-C28;
A24-B1-C34;
A24-B1-C40;
A24-B1-C46;
A25-B1-C1;
A25-B1-C7;
A25-B1-C13;
A25-B1-C19;
A25-B1-C25;
A25-B1-C31;
A25-B1-C37;
A25-B1-C43;
A26-B1-C3;
A26-B1-C9;
A26-B1-C15;
A26-B1-C21;
A26-B1-C27;
A26-B1-C33;
A26-B1-C39;
A26-B1-C45;
A27-B1-C5;
A27-B1-C11;
A27-B1-C17;
A27-B1-C23;
A27-B1-C29;
A27-B1-C35;
A27-B1-C41; A28-B1-C1; A28-B1-C7;
A28-B1-C13;
A28-B1-C19;
A28-B1-C25;
A28-B1-C31;
A28-B1-C37;
A28-B1-C43;
A1-B2-C3;
A1-B2-C9;
A1-B2-C15 ;. A1-B2-C21; A1-B2-C27; A1-B2-C33;
A1-B2-C39;
A1-B2-C45;
A2-B2-C5;
A2-B2-C11;
A2-B2-C17;
A2-B2-C23;
A2-B2-C29;
A2-B2-C35;
A2-B2-C41;
A3-B2-C1;
A3-B2-C7;
A3-B2-C13;
A3-B2-C19;
A3-B2-C25;
A3-B2-C31;
A3-B2-C37;
A3-B2-C43;
A4-B2-C3;
A4-32-C9;
A4-B2-C15;
A4-32-C21;
A4-B2-C27;
A4-B2-C33;
A4-B2-C39;
A4-B2-C45;
A5-B2-C5;
A25-B1-C2;
A25-B1-C8;
A25-B1-C14;
A25-B1-C20;
A25-B1-C26;
A25-B1-C32;
A25-B1-C38;
A25-B1-C44;
A26-B1-C4;
A26-B1-C10;
A26-B1-C16;
A26-B1-C22;
A26-B1-C28;
A26-B1-C34;
A26-B1-C40;
A26-B1-C46;
A27-B1-C6;
A27-B1-C12;
A27-B1-C18;
A27-B1-C24;
A27-B1-C30;
A27-B1-C36; A27-B1-C42; A28-B1-C2;
A28-B1-C8;
A28-B1-C14;
A28-B1-C20;
A28-B1-C26;
A28-B1-C32;
A28-B1-C38;
A28-B1-C44; A1-B2-C4;
A1-B2-C10;
A1-B2-C16;
A1-B2-C22;
A1-B2-C28;
A1-B2-C34;
A1-B2-C40;
A1-B2-C46;
A2-B2-C6;
A2-B2-C12;
A2-B2-C18;
A2-B2-C24;
A2-B2-C30;
A2-B2-C36;
A2-B2-C42; A3-B2-C2;
A3-B2-C8;
A3-B2-C14;
A3-B2-C20;
A3-B2-C26;
A3-B2-C32;
A3-B2-C38;
A3-B2-C44;
A4-B2-C4;
A4-B2-C10;
A4-B2-C16;
A4-B2-C22;
A4-B2-C28;
A4-B2-C34;
A4-B2-C40;
A4-B2-C46;
A5-B2-C6;
A25-B1-C3;
A25-B1-C9;
A25-B1-C15;
A25-B1-C21;
A25-B1-C27;
A25-B1-C33;
A25-B1-C39;
A25-B1-C45;
A26-B1-C5;
A26-B1-C11;
A26-B1-C17;
A26-B1-C23;
A26-B1-C29;
A26-B1-C35;
A26-B1-C41;
A27-B1-C1;
A27-B1-C7;
A27-B1-C13;
A27-B1-C19;
A27-B1-C25;
A27-B1-C31;
A27-B1-C37;
A27-B1-C43;
A28-B1-C3;
A28-B1-C9;
A28-B1-C15;
A28-B1-C21;
A28-B1-C27;
A28-B1-C33;
A28-B1-C39;
A28-B1-C45;
A1-B2-C5;
A1-B2-C11;
A1-B2-C17;
A1-B2-C23;
A1-B2-C29;
A1-B2-C35;
A1-B2-C41;
A2-B2-C1;
A2-B2-C7;
A2-B2-C13;
A2-B2-C19;
A2-B2-C25;
A2-B2-C31;
A2-B2-C37;
A2-B2-C43;
A3-B2-C3;
A3-B2-C9;
A3-B2-C15;
A3-B2-C21;
A3-B2-C27;
A3-B2-C33;
A3-B2-C39;
A3-B2-C45;
A4-B2-C5;
A4-B2-C11;
A4-B2-C17;
A4-B2-C23;
A4-B2-C29;
A4-B2-C35;
A4-B2-C41;
A5-B2-C1;
A5-B2-C7;
A25-B1-C4;
A25-B1-C10; A25-B1-C16; A25-B1-C22; A25-B1-C28; A25-B1-C34; A25-B1-C40; A25-B1-C46; A26-B1-C6;
A26-B1-C12; A26-B1-C18; A26-B1-C24; A26-B1-C30; A26-B1-C36; A26-B1-C42; A27-B1-C2; A27-B1-C8;
A27-B1-C14; A27-B1-C20; A27-B1-C26; A27-B1-C32; A27-B1-C38; A27-B1-C44; A28-B1-C4;
A28-B1-C10; A28-B1-C16; A28-B1-C22; A28-B1-C28; A28-B1-C34; A28-B1-C40; A28-B1-C46; A1-B2-C6;
A1-B2-C12; A1-B2-C18; A1-B2-C24;
A1-B2-C30;
A1-E2-C36; A1-B2-C42; A2-B2-C2; A2-B2-C8;
A2-B2-C14; A2-B2-C20; A2-B2-C26; A2-B2-C32; A2-B2-C38; A2-B2-C44; A3-B2-C4;
A3-B2-C10;
A3-B2-C16;
A3-B2-C22;
A3-B2-C28;
A3-B2-C34;
A3-B2-C40;
A3-B2-C46;
A4-B2-C6;
A4-B2-C12; A4-B2-C18; A4-B2-C24; A4-B2-C30; A4-B2-C36; A4-B2-C42;
A5-B2-C2; A5-B2-C8;
A25-B1-C5;
A25-B1-C11;
A25-B1-C17;
A25-B1-C23;
A25-B1-C29;
A25-B1-C35;
A25-B1-C41;
A26-B1-C1;
A26-B1-C7;
A26-B1-C13;
A26-B1-C19;
A26-B1-C25;
A26-B1-C31;
A26-B1-C37;
A26-B1-C43;
A27-B1-C3;
A27-B1-C9;
A27-B1-C15;
A27-B1-C21;
A27-B1-C27;
A27-B1-C33;
A27-B1-C39;
A27-B1-C45;
A28-B1-C5;
A28-B1-C11;
A28-B1-C17;
A28-B1-C23;
A28-B1-C29;
A28-B1-C35;
A28-B1-C41;
A1-B2-C1;
A1-B2-C7;
A1-B2-C13;
A1-B2-C19;
A1-B2-C25;
A1-B2-C31;
A1-B2-C37;
A1-B2-C43;
A2-B2-C3;
A2-B2-C9;
A2-B2-C15;
A2-B2-C21;
A2-B2-C27;
A2-B2-C33;
A2-B2-C39; '
A2-B2-C45;
A3-B2-C5;
A3-B2-C11;
A3-B2-C17;
A3-B2-C23;
A3-B2-C29;
A3-B2-C35;
A3-B2-C41;
A4-B2-C1;
A4-B2-C7;
A4-B2-C13;
A4-B2-C19;
A4-B2-C25;
A4-B2-C31;
A4-B2-C37;
A4-B2-C43;
A5-B2-C3;
A5-B2-C9;
A25-B1-C6;
A25-B1-C12;
A25-B1-C18;
A25-B1-C24;
A25-B1-C30;
A25-B1-C36;
A25-B1-C42;
A26-B1-C2;
A26-B1-C8;
Α26-B1-C14;
A26-B1-C20;
A26-BI-C26;
A26-B1-C32;
A26-B1-C38;
A26-B1-C44;
A27-B1-C4;
A27-B1-C10;
A27-B1-C16;
A27-B1-C22;
A27-B1-C28;
A27-B1-C34;
A27-B1-C40;
A27-B1-C46;
A28-B1-C6;
A28-B1-C12;
A28-B1-C18;
A28-B1-C24;
A28-B1-C30;
A28-B1-C36;
A28-B1-C42;
A1-B2-C2;
A1-B2-C8;
A1-B2-C14;
A1-B2-C20;
A1-B2-C26 ;.
A1-B2-C32;
A1-B2-C38;
A1-B2-C44;
A2-B2-C4;
A2-B2-C10;
A2-B2-C16;
A2-B2-C22;
A2-B2-C28;
A2-B2-C34; '
A2-B2-C40;
A2-B2-C46;
A3-B2-C6;
A3-B2-C12;
A3-B2-C18;
A3-B2-C24;
A3-B2-C30;
A3-B2-C36;
A3-B2-C42;
A4-B2-C2;
A4-B2-C8;
A4-B2-C14;
A4-B2-C20;
A4-B2-C26;
A4-B2-C32;
A4-B2-C38;
A4-B2-C44;
A5-B2-C4;
A5-B2-C10;
A5-B2-C11;
A5-B2-C17;
A5-B2-C23;
A5-B2-C29;
A5-B2-C35;
A5-B2-C41;
A6-B2-C1;
A6-B2-C7;
A6-B2-C13;
A6-B2-C19;
A6-B2-C25;
A6-B2-C31;
A6-B2-C37;
A6-B2-C43;
A7-B2-C3;
A7-B2-C9;
A7-B2-C15;
A7-B2-C21;
A7-B2-C27;
A7-B2-C33;
A7-B2-C39;
A7-B2-C45;
A8-B2-C5;
A8-B2-C11;
A8-C17-B 2;
A8-B2-C23;
A8-B2-C29;
A8-B2-C35;
A8-B2-C41;
A9-B2-C1;
A9-B2-C7;
A9-B2-C13;
A9-B2-C19;
A9-B2-C25;
A9-B2-C31;
A9-B2-C37;
A9-B2-C43;
A10-B2-C3;
A10-B2-C9;
A10-B2-C15;
A10-B2-C21;
A10-B2-C27;
A10-B2-C33;
A10-B2-C39;
A10-B2-C45;
A11-B2-C5;
A11-B2-C11;
A11-B2-C17;
A11-B2-C23;
A11-B2-C29;
A11-B2-C35;
A11-B2-C41;
A12-B2-C1;
A12-B2-C7;
A12-B2-C13;
A12-B2-C19;
A12-B2-C25;
A12-B2-C31;
A12-B2-C37;
A12-B2-C43;
A13-B2-C3;
A13-B2-C9;
A13-B2-C15;
A5-B2-C12;
A5-B2-C18;
A5-B2-C24;
A5-B2-C30;
A5-B2-C36;
A5-B2-C42;
A6-B2-C2;
A6-B2-C8;
A6-B2-C14;
A6-B2-C20;
A6-B2-C26;
A6-B2-C32;
A6-B2-C38;
A6-B2-C44;
A7-B2-C4;
A7-B2-C10;
A7-B2-C16;
A7-B2-C22;
A7-B2-C28;
A7-B2-C34;
A7-B2-C40;
A7-B2-C46;
A8-B2-C6;
A8-B2-C12;
A8-B2-C18;
A8-B2-C24;
A8-B2-C30;
A8-B2-C36;
A8-B2-C42;
A9-B2-C2;
A9-B2-C8;
A9-B2-C14;
A9-B2-C20;
A9-B2-C26;
A9-B2-C32;
A9-B2-C38;
A9-B2-C44;
A10-B2-C4;
A10-B2-C10;
A10-B2-C16;
A10-B2-C22;
A10-B2-C28;
A10-B2-C34;
A10-B2-C40;
A10-B2-C46;
A11-B2-C6;
A11-B2-C12;
A11-B2-C18;
A11-B2-C24;
A11-B2-C30;
A11-B2-C36;
A11-B2-C42;
A12-B2-C2;
A12-B2-C8;
A12-B2-C14;
A12-B2-C20;
A12-B2-C26;
A12-B2-C32;
A12-B2-C38;
A12-B2-C44;
A13-B2-C4;
A13-B2-C10;
A13-B2-C16;
A5-B2-C13;
A5-B2-C19;
A5-B2-C25;
A5-B2-C31;
A5-B2-C37;
A5-B2-C43;
A6-B2-C3;
A6-B2-C9;
A6-B2-C15;
A6-B2-C21;
A6-B2-C27;
A6-B2-C33;
A6-B2-C39;
A6-B2-C45;
A7-B2-C5;
A7-B2-C11;
A7-B2-C17;
A7-B2-C23;
A7-B2-C29;
A7-B2-C35;
A7-B2-C41;
A8-B2-C1;
A8-B2-C7;
A8-B2-C13;
A8-B2-C19;
A8-B2-C25;
A8-B2-C31;
A8-B2-C37;
A8-B2-C43;
A9-B2-C3;
A9-B2-C9;
A9-B2-C15;
A9-B2-C21;
A9-B2-C27;
A9-B2-C33;
A9-B2-C39;
A9-B2-C45;
A10-B2-C5;
A10-B2-C11;
A10-B2-C17;
A10-B2-C23;
A10-B2-C29;
A10-B2-C35;
A10-B2-C41;
A11-B2-C1;
A11-B2-C7;
A11-B2-C13;
A11-B2-C19;
A11-B2-C25;
A11-B2-C31;
A11-B2-C37;
A11-B2-C43;
A12-B2-C3;
A12-B2-C9;
A12-B2-C15;
A12-B2-C21;
A12-B2-C27;
A12-B2-C33;
A12-B2-C39;
A12-B2-C45;
A13-B2-C5;
A13-B2-C11;
A13-B2-C17;
A5-B2-C14;
A5-B2-C20;
A5-B2-C26;
A5-B2-C32;
A5-B2-C38; A5-B2-C44; A6-B2-C4;
A6-B2-C10;
A6-B2-C16;
A6-B2-C22;
A6-B2-C28;
A6-B2-C34;
A6-B2-C40;
A6-B2-C46;
A7-B2-C6;
A7-B2-C12;
A7-B2-C18;
A7-B2-C24;
A7-B2-C30;
A7-B2-C36;
A7-B2-C42;
A8-B2-C2;
A8-B2-C8;
A8-B2-C14;
A8-B2-C20;
A8-B2-C26;
A8-B2-C32;
A8-B2-C38;
A8-B2-C44;
A9-B2-C4;
A9-B2-C10;
A9-B2-C16;
A9-B2-C22;
A9-B2-C28; A9-B2-C34; A9-B2-C40; A9-B2-C46;
A10-B2-C6;
A10-B2-C12; A10-B2-C18; A10-B2-C24; A10-B2-C30; A10-B2-C36;
A10-B2-C42;
A11-B2-C2;
A11-B2-C8;
A11-B2-C14;
A11-B2-C20;
A11-B2-C26;
A11-B2-C32;
A11-B2-C38;
A11-B2-C44; A12-B2-C4;
A12-B2-C10;
A12-B2-C16;
A12-B2-C22;
A12-B2-C28;
A12-B2-C34;
A12-B2-C40;
A12-B2-C4'6;
A13-B2-C6;
A13-B2-C12;
A13-B2-C18;
A5-B2-C15;
A5-B2-C21;
A5-B2-C27;
A5-B2-C33;
A5-B2-C39;
A5-B2-C45;
A6-B2-C5;
A6-B2-C11;
A6-B2-C17;
A6-B2-C23;
A6-B2-C29;
A6-B2-C35;
A6-B2-C41;
A7-B2-C1;
A7-B2-C7;
A7-B2-C13;
A7-B2-C19;
A7-B2-C25;
A7-B2-C31;
A7-B2-C37;
A7-B2-C43;
A8-B2-C3;
A8-B2-C9;
A8-B2-C15;
A8-B2-C21;
A8-B2-C27;
A8-B2-C33;
A8-B2-C39;
A8-B2-C45;
A9-B2-C5;
A9-B2-C11;
A9-B2-C17;
A9-B2-C23;
A9-B2-C29;
A9-B2-C35;
A9-B2-C41;
A10-B2-C1;
A10-B2-C7;
A10-B2-C13;
A10-B2-C19;
A10-B2-C25;
A10-B2-C31;
A10-B2-C37;
A10-B2-C43;
A11-B2-C3; '
A11-B2-C9;
A11-B2-C15;
A11-B2-C21;
A11-B2-C27;
A11-B2-C33;
A11-B2-C39;
A11-B2-C45; A12-B2-C5;
A12-B2-C11;
A12-B2-C17;
A12-B2-C23;
A12-B2-C29;
A12-B2-C35;
A12-B2-C41;
A13-B2-C1;
A13-B2-C7;
A13-B2-C13;
A13-B2-C19;
A5-B2-C16;
A5-B2-C22;
A5-B2-C28;
A5-B2-C34;
A5-B2-C40;
A5-B2-C46;
A6-B2-C6;
A6-B2-C12;
A6-B2-C18;
A6-B2-C24;
A6-B2-C30;
A6-B2-C36;
A6-B2-C42;
A7-B2-C2;
A7-B2-C8;
A7-B2-C14;
A7-B2-C20;
A7-B2-C26;
A7-B2-C32;
A7-B2-C38;
A7-B2-C44;
A8-B2-C4;
A8-B2-C10;
A8-B2-C16;
A8-B2-C22;
A8-B2-C28;
A8-B2-C34;
A8-B2-C40;
A8-B2-C46;
A9-B2-C6;
A9-B2-C12;
A9-B2-C18; A9-B2-C24; A9-B2-C30;
• A9-B2-C36;
A9-B2-C42; .
A10-B2-C2;
A10-B2-C8;
A10-B2-C14;
A10-B2-C20;
A10-B2-C26;
A10-B2-C32;
A10-32-C38;
A10-B2-C44;
A11-B2-C4;
A11-B2-C10;
A11-B2-C16;
A11-B2-C22;
A11-B2-C28;
A11-B2-C34;
A11-B2-C40;
A11-B2-C46;
A12-B2-C6;
A12-B2-C12;
A12-B2-C18;
A12-B2-C24;
A12-B2-C30;
A12-B2-C36;
A12-B2-C42;
A13-B2-C2;
A13-B2-C8;
A13-B2-C14;
A13-B2-C20;
A13-B2-C21;
A13-B2-C27;
A13-B2-C33;
A13-B2-C39;
A13-B2-C45; A14-B2-C5;
A14-B2-C11;
A14-B2-C17;
A14-B2-C23;
A14-B2-C29;
A14-B2-C35;
A14-B2-C41;
A15-B2-C1;
A15-B2-C7;
A15-B2-C13;
A15-B2-C19;
A15-B2-C25;
A15-B2-C31;
A15-B2-C37;
A15-B2-C43;
A16-B2-C3;
A16-B2-C9;
A16-B2-C15;
A16-B2-C21;
A16-B2-C27;
A16-B2-C33;
A16-B2-C39;
A16-B2-C45; A17-B2-C5;
A17-B2-C11;
A17-B2-C17;
A17-B2-C23;
A17-B2-C29;
A17-B2-C35;
A17-B2-C41;
A18-B2-C1;
A18-B2-C7;
A18-B2-C13;
A18-B2-C19;
A18-B2-C25;
A18-B2-C31;
A18-B2-C37;
A18-B2-C43; A19-B2-C3;
A19-B2-C9;
A19-B2-C15;
A19-B2-C21;
A19-B2-C27;
A19-B2-C33;
A19-B2-C39;
A19-B2-C45; A20-B2-C5;
A20-B2-C11;
A20-B2-C17;
A20-B2-C23;
A20-B2-C29;
A20-B2-C35;
A20-B2-C41;
A21-B2-C1;
A21-B2-C7;
A21-B2-C13;
A21-B2-C19;
A21-B2-C25;
A13-B2-C22;
A13-B2-C28;
A13-B2-C34;
A13-B2-C40;
A13-B2-C46;
A14-B2-C6;
A14-B2-C12;
A14-B2-C18;
A14-B2-C24;
A14-B2-C30;
A14-B2-C36;
A14-B2-C42;
A15-B2-C2;
A15-B2-C8;
A15-B2-C14;
A15-B2-C20;
A15-B2-C26;
A15-B2-C32;
A15-B2-C38;
A15-B2-C44;
A16-B2-C4;
A16-B2-C10;
A16-B2-C16;
A16-B2-C22;
A16-B2-C28;
A16-B2-C34;
A16-B2-C40;
A16-B2-C46;
A17-B2-C6;
A17-B2-C12;
A17-B2-C18;
A17-B2-C24;
A17-B2-C30;
A17-B2-C36;
A17-B2-C42;
A18-B2-C2;
A18-B2-C8;
A18-B2-C14;
A18-B2-C20;
A18-B2-C26;
A18-B2-C32;
A18-B2-C38;
A18-B2-C44;
A19-B2-C4;
A19-B2-C10;
A19-B2-C16;
A19-B2-C22;
A19-B2-C28 ';
A19-B2-C34;
A19-B2-C40;
A19-B2-C46;
A20-B2-C6;
A20-B2-C12;
A20-B2-C18;
A20-B2-C24;
A20-B2-C30;
A20-B2-C36;
A20-B2-C42;
A21-B2-C2;
A21-B2-C8;
A21-B2-C14;
A21-B2-C20;
A21-B2-C26;
A13-B2-C23;
A13-B2-C29;
A13-B2-C35;
A13-B2-C41;
A14-B2-C1;
A14-B2-C7;
A14-B2-C13;
A14-B2-C19;
A14-B2-C25;
A14-B2-C31;
A14-B2-C37;
A14-B2-C43;
A15-B2-C3;
A15-B2-C9;
A15-B2-C15;
A15-B2-C21;
A15-B2-C27;
A15-B2-C33;
A15-B2-C39;
A15-B2-C45;
A16-B2-C5;
A16-B2-C11;
A16-B2-C17;
A16-B2-C23;
A16-B2-C29;
A16-B2-C35;
A16-B2-C41;
A17-B2-C1; '
A17-B2-C7;
A17-B2-C13;
A17-B2-C19;
A17-B2-C25;
A17-B2-C31;
A17-B2-C37;
A17-B2-C43;
A18-B2-C3;
A18-B2-C9;
A18-B2-C15;
A18-B2-C21;
A18-B2-C27;
A18-B2-C33;
A18-B2-C39;
A18-B2-C45; A19-B2-C5;
A19-B2-C11;
A19-B2-C17;
A19-B2-C23;
A19-B2-C29;
A19-B2-C35;
A19-B2-C41;
A20-B2-C1;
A20-B2-C7;
A20-B2-C13;
A20-B2-C19;
A20-B2-C25;
A20-B2-C31;
A20-B2-C37;
A20-B2-C43;
A21-B2-C3;
A21-B2-C9;
A21-B2-C15;
A21-B2-C21;
A21-B2-C27;
A13-B2-C24;
A13-B2-C30;
A13-B2-C36;
A13-B2-C42;
A14-B2-C2;
A14-B2-C8;
A14-B2-C14;
A14-B2-C20;
A14-B2-C26;
A14-B2-C32;
A14-B2-C38;
A14-B2-C44;
A15-B2-C4;
A15-B2-C10;
A15-B2-C16;
A15-B2-C22;
A15-B2-C28;
A15-B2-C34;
A15-B2-C40;
A15-B2-C46;
A16-B2-C6;
A16-B2-C12;
A16-B2-C18;
A16-B2-C24;
A16-B2-C30;
A16-B2-C36;
A16-B2-C42;
A17-B2-C2;
A17-B2-C8;
A17-B2-C14;
A17-B2-C20;
A17-B2-C26;
A17-B2-C32;
A17-B2-C38;
A17-B2-C44;
A18-B2-C4;
A18-B2-C10;
A18-B2-C16;
A18-B2-C22;
A18-B2-C28;
A18-B2-C34;
A18-B2-C40;
A18-B2-C46;
A19-B2-C6;
A19-B2-C12;
A19-B2-C18;
A19-B2-C24;
A19-B2-C30;
A19-B2-C36;
A19-B2-C42;
A20-B2-C2;
A20-B2-C8;
A20-B2-C14;
A20-B2-C20;
A20-B2-C26;
A20-B2-C32;
A20-B2-C38;
A20-B2-C44;
A21-B2-C4;
A21-B2-C10;
A21-B2-C16;
A21-B2-C22;
A21-B2-C28;
A13-B2-C25;
A13-B2-C31;
A13-B2-C37;
A13-B2-C43;
A14-B2-C3;
A14-B2-C9;
A14-B2-C15;
A14-B2-C21;
A14-B2-C27;
A14-B2-C33;
A14-B2-C39;
A14-B2-C45;
A15-B2-C5;
A15-B2-C11;
A15-B2-C17;
A15-B2-C23;
A15-B2-C29;
A15-B2-C35;
A15-B2-C41;
A16-B2-C1;
A16-B2-C7;
A16-B2-C13;
A16-B2-C19;
A16-B2-C25;
A16-B2-C31;
A16-B2-C37;
A16-B2-C43;
A17-B2-C3;
A17-B2-C9;
A17-B2-C15;
A17-B2-C21;
A17-B2-C27;
A17-B2-C33;
A17-B2-C39;
A17-B2-C45; A18-B2-C5;
A18-B2-C11;
A18-B2-C17;
A18-B2-C23;
A18-B2-C29;
A18-B2-C35;
A18-B2-C41;
A19-B2-C1;
A19-B2-C7;
A19-B2-C13;
A19-B2-C19;
A19-B2-C25;
A19-B2-C31;
A19-B2-C37;
A19-B2-C43;
A20-B2-C3;
A20-B2-C9;
A20-B2-C15;
A20-B2-C21;
A20-B2-C27;
A20-B2-C33;
A20-B2-C39;
A20-B2-C45;
A21-B2-C5;
A21-B2-C11;
A21-B2-C17;
A21-B2-C23;
A21-B2-C29;
A13-B2-C26;
A13-B2-C32;
A13-B2-C38;
A13-B2-C44; A14-B2-C4;
A14-B2-C10;
A14-B2-C16;
A14-B2-C22;
A14-B2-C28;
A14-B2-C34;
A14-B2-C40;
A14-B2-C46;
A15-B2-C6;
A15-B2-C12;
A15-B2-C18;
A15-B2-C24;
A15-B2-C30;
A15-B2-C36;
A15-B2-C42;
A16-B2-C2;
A16-B2-C8;
A16-B2-C14;
A16-B2-C20;
A16-B2-C26;
A16-B2-C32;
A16-B2-C38;
A16-B2-C44;
A17-B2-C4;
A17-B2-C10;
A17-B2-C16;
A17-B2-C22;
A17-B2-C28;
A17-B2-C34;
A17-B2-C40;
A17-B2-C46;
A18-B2-C6;
A18-B2-C12;
A18-B2-C18;
A18-B2-C24;
A18-32-C30;
A18-B2-C36;
A18-B2-C42;
A19-B2-C2;
A19-B2-C8;
A19-B2-C14;
A19-B2-C20;
A19-B2-C26;
A19-B2-C32;
A19-B2-C38;
A19-B2-C44;
A20-B2-C4;
A20-B2-C10;
A20-B2-C16;
A20-B2-C22;
A20-B2-C28;
A20-B2-C34;
A20-B2-C40;
A20-B2-C46;
A21-B2-C6;
A21-B2-C12;
A21-B2-C18;
A21-B2-C24;
A21-B2-C30;
A21-B2-C31;
A21-B2-C37;
A21-B2-C43;
A22-B2-C3;
A22-B2-C9;
A22-B2-C15;
A22-B2-C21;
A22-B2-C27;
A22-B2-C33;
A22-B2-C39;
A22-B2-C45; A23-B2-C5;
A23-B2-C11;
A23-B2-C17;
A23-B2-C23;
A23-B2-C29;
A23-B2-C35;
A23-B2-C41;
A24-B2-C1;
A24-B2-C7;
A24-B2-C13;
A24-B2-C19;
A24-B2-C25;
A24-B2-C31;
A24-B2-C37;
A24-B2-C43;
A25-B2-C3;
A25-B2-C9;
A25-B2-C15;
A25-B2-C21;
A25-B2-C27;
A25-B2-C33;
A25-B2-C39;
A25-B2-C45; A26-B2-C5;
A26-B2-C11;
A26-B2-C17;
A26-B2-C23;
A26-B2-C29;
A26-B2-C35;
A26-B2-C41;
A27-B2-C1;
Α27-B2-C7;
A27-B2-C13;
A27-B2-C19;
A27-B2-C25;
A27-B2-C31;
A27-B2-C37;
A27-B2-C43;
A28-B2-C3;
A28-B2-C9;
A28-B2-C15;
A28-B2-C21;
A28-B2-C27;
A28-B2-C33;
A28-B2-C39;
A28-B2-C45; A1-B3-C5;
A1-B3-C11;
A1-B3-C17;
A1-B3-C23;
A1-B3-C29;
A1-B3-C35;
A21-B2-C32;
A21-B2-C38;
A21-B2-C44; A22-B2-C4;
A22-B2-C10;
A22-B2-C16;
A22-B2-C22;
A22-B2-C28;
A22-B2-C34;
A22-B2-C40;
A22-B2-C46;
A23-B2-C6;
A23-B2-C12;
A23-B2-C18;
A23-B2-C24;
A23-B2-C30;
A23-B2-C36;
A23-B2-C42;
A24-B2-C2;
A24-B2-C8;
A24-B2-C14;
A24-B2-C20;
A24-B2-C26;
A24-B2-C32;
A24-B2 C38-;
A24-B2-C44;
A25-B2-C4; <sup>1</sup>
A25-B2-C10;
A25-B2-C16;
A25-B2-C22;
A25-B2-C28;
A25-B2-C34;
A25-B2-C40;
A25-B2-C46;
A26-B2-C6;
A26-B2-C12;
A26-B2-C18;
A26-B2-C24;
A26-B2-C30;
A26-B2-C36;
A26-B2-C42;
A27-B2-C2;
A27-B2-C8;
A27-B2-C14;
A27-B2-C20;
A27-B2-C26;
A27-B2-C32;
A27-B2-C38;
A27-B2-C44;
A28-B2-C4;
A28-B2-C10;
A28-B2-C16;
A28-B2-C22;
A28-B2-C28;
A28-B2-C34;
A28-B2-C40;
A28-B2-C46;
A1-B3-C6;
A1-B3-C12;
A1-B3-C18;
A1-B3-C24;
A1-B3-C30;
A1-B3-C36;
A21-B2-C33;
A21-B2-C39;
A21-B2-C45;
A22-B2-C5;
A22-B2-C11;
A22-B2-C17;
A22-B2-C23;
A22-B2-C29;
A22-B2-C35;
A22-B2-C41;
A23-B2-C1 ;.
A23-B2-C7;
A23-B2-C13;
A23-B2-C19;
A23-B2-C25;
A23-B2-C31;
A23-B2-C37;
A23-B2-C43;
A24-B2-C3;
A24-B2-C9;
A24-B2-C15;
A24-B2-C21;
A24-B2-C27;
A24-B2-C33;
A24-B2-C39;
A24-B2-C45; A25-B2-C5;
A25-B2-C11;
A25-B2-C17;
A25-B2-C23;
A25-B2-C29;
A25-B2-C35;
A25-B2-C41;
A26-B2-C1;
A26-B2-C7;
A26-B2-C13;
A26-B2-C19;
A26-B2-C25;
A26-B2 -C 31;
A26-B2-C37;
A26-B2-C43;
A27-B2-C3;
A27-B2-C9;
A27-B2-C15;
A27-B2-C21;
A27-B2-C27;
A27-B2-C33;
A27-B2-C39;
A27-B2-C45; A28-B2-C5;
A28-B2-C11;
A28-B2-C17;
A28-B2-C23;
A28-B2-C29;
A28-B2-C35;
A28-B2-C41;
A1-B3-C1;
A1-B3-C7;
A1-B3-C13;
A1-B3-C19;
A1-B3-C25;
A1-B3-C31;
A1-B3-C37;
A21-B2-C34;
A21-B2-C40;
A21-B2-C46;
A22-B2-C6;
A22-B2-C12;
A22-B2-C18;
A22-B2-C24;
A22-B2 -C 30;
A22-B2-C36;
A22-B2-C42;
A23-B2-C2;
A23-B2-C8;
A23-B2-C 14;
A23-B2-C20;
A23-B2-C26;
A23-B2-C32;
A23-B2-C38;
A23-B2-C44;
A24-B2-C4;
A24-B2-C10;
A24-B2-C16;
A24-B2-C22;
A24-B2-C28;
A24-B2-C34;
A24-B2-C40;
A24-B2-C46;
A25-B2-C6;
A25-B2-C12;
A25-B2-C 18;
A25-B2-C24;
A25-B2-C30;
A25-B2-C36;
A25-B2-C42;
A26-B2-C2;
A26-B2-C8;
A26-B2-C14;
A26-B2-C20;
A26-B2-C26;
A26-B2-C32;
A26-B2-C38;
A26-B2-C44;
A27-B2-C4;
A27-B2-C10;
A27-B2-C16;
A27-B2-C22;
A27-B2-C28;
A27-B2-C34;
A27-B2-C40;
A27-B2-C46;
A28-B2-C6;
A28-B2-C12;
A28-B2-C 18;
A28-B2-C24;
A28-B2-C30;
A28-B2-C36;
A28-B2-C42;
A1-B3-C2;
A1-B3-C8;
A1-B3-C14;
A1-B3-C20;
A1-B3-C26;
A1-B3-C32;
A1-B3-C38;
A21-B2-C35;
A21-B2-C41;
A22-B2-C1;
A22-B2-C7;
A22-B2-C13;
A22-B2-C19;
A22-B2-C25;
A22-B2-C31;
A22-B2-C37;
A22-B2-C43;
A23-B2-C3;
A23-B2-C9;
A23-B2-C15;
A23-B2-C21;
A23-B2-C27;
A23-B2-C33;
A23-B2-C39;
A23-B2-C45;
A24-B2-C5;
A24-B2-C11;
A24-B2-C17;
A24-B2-C23;
A24-B2-C29;
A24-B2-C35;
A24-B2-C41;
A25-B2-C1;
A25-B2-C7;
A25-B2-C13;
A25-B2-C19;
A25-B2-C25;
A25-B2-C31;
A25-B2-C37;
A25-B2-C43;
A26-B2-C3;
A26-B2-C9;
A26-B2-C15;
A26-B2-C21;
A26-B2-C27;
A26-B2-C33;
A26-B2-C39;
A26-B2-C45;
A27-B2-C5;
A27-B2-C11;
A27-B2-C17;
A27-B2-C23;
A27-B2-C29;
A27-B2-C35;
A27-B2-C41;
A28-B2-C1;
A28-B2-C7;
A28-B2-C13;
A28-B2-C19;
A28-B2-C25;
A28-B2-C31;
A28-B2-C37;
A28-B2-C43;
A1-B3-C3;
A1-B3-C9;
A1-B3-C15;
A1-B3-C21;
A1-B3-C27;
A1-B3-C33;
A1-B3-C39;
A21-B2-C36;
A21-B2-C42;
A22-B2-C2;
A22-B2-C8;
A22-B2-C14;
A22-B2-C20;
A22-B2-C26;
A22-B2-C32;
A22-B2-C38;
A22-B2-C44; A23-B2-C4;
A23-B2-C10;
A23-B2-C16;
A23-B2-C22;
A23-B2-C28; A23-B2-C34;
A23-B2-C40;
A23-B2-C46;
A24-B2-C6;
A24-B2-C12;
A24-B2-C18;
A24-B2-C24;
A24-B2-C30;
A24-B2-C36;
A24-B2-C42;
A25-B2-C2;
A25-B2-C8;
A25-B2-C14;
A25-B2-C20;
A25-B2-C26;
A25-B2-C32;
-A25-B2 C38;
A25-B2-C44;
A26-B2-C4;
A26-B2-C10;
A26-B2-C16;
A26-B2-C22;
A26-B2-C28;
A26-B2-C34;
A26-B2-C40;
A26-B2-C46;
A27-B2-C6;
A27-B2-C12;
A27-B2-C18;
A27-B2-C24;
A27-B2-C30;
A27-B2-C36;
-B2-A27 C42;
A28-B2-C2;
A28-B2-C8;
A28-B2-C14;
A28-B2-C20;
A28-B2-C26;
A28-B2-C32;
A28-B2-C38;
A28-B2-C44; A1-B3-C4;
A1-B3-C10;
A1-B3-C16;
A1-B3-C22;
A1-B3-C28;
A1-B3-C34;
A1-B3-C40;
A1-B3-C41; A2-B3-C1; A2-B3-C7;
A2-B3-C13;
A2-B3-C19;
A2-B3-C25;
A2-B3-C31;
A2-B3-C37;
A2-B3-C43;
A3-B3-C3;
A3-B3-C9;
A3-B3-C15;
A3-B3-C21;
A3-B3-C27;
A3-B3-C33;
A3-B3-C39;
A3-B3-C45;
A4-B3-C5;
A4-B3-C11;
A4-B3-C17;
A4-B3-C23;
A4-B3-C29;
A4-B3-C35;
A4-B3-C41;
A5-B3-C1;
A5-B3-C7;
A5-B3-C13;
A5-B3-C19;
A5-B3-C25;
A5-B3-C31;
A5-B3-C37;
A5-B3-C43;
A6-B3-C3;
A6-B3-C9;
A6-B3-C15;
A6-B3-C21;
A6-B3-C27;
A6-B3-C33;
A6-B3-C39;
A6-B3-C45; A7-B3-C5;
A7-B3-C11;
A7-B3-C17;
A7-B3-C23;
A7-B3-C29;
A7-B3-C35;
A7-B3-C41;
A8-B3-C1;
A8-B3-C7;
A8-B3-C13;
A8-B3-C19;
A8-B3-C25;
A8-B3-C31;
A8-B3-C37;
A8-B3-C43;
A9-B3-C3;
A9-B3-C9;
A9-B3-C15;
A9-B3-C21;
-B3-A9 C27;
A9-B3-C33;
A9-B3-C39;
A9-B3-C45;
A1-B3-C42;
A2-B3-C2;
A2-B3-C8;
A2-B3-C14;
A2-B3-C20;
A2-B3-C26;
A2-B3-C32;
A2-B3-C38;
A2-B3-C44; A3-B3-C4;
A3-B3-C10;
A3-B3-C16;
A3-B3-C22;
A3-B3-C28; A3-B3-C34; A3-B3-C40; A3-B3-C46;
A4-B3-C6;
A4-B3-C12;
A4-B3-C18;
A4-B3-C24;
A4-B3-C30;
A4-B3-C36;
A4-B3-C42;
A5-B3-C2;
A5-B3-C8;
A5-B3-C14;
A5-B3-C20;
A5-B3-C26;
A5-B3-C32;
A5-B3-C38;
A5-B3-C44; A6-B3-C4;
A6-B3-C10;
A6-B3-C16;
A6-B3-C22;
A6-B3-C28;
A6-B3-C34;
A6-B3-C40;
A6-B3-C46; A7-B3-C6;
A7-B3-C12;
A7-B3-C18;
A7-B3-C24;
A7-B3-C30; A7-B3-C36 ;. A7-B3-C42;
A8-B3-C2;
A8-B3-C8;
A8-B3-C14;
A8-B3-C20;
A8-B3-C26;
A8-B3-C32;
A8-B3-C38;
A8-B3-C44; A9-B3-C4;
A9-B3-C10;
A9-B3-C16;
A9-B3-C22;
A9-B3-C28;
A9-B3-C34;
A9-B3-C40;
A9-B3-C46;
A1-B3-C43;
A2-B3-C3;
A2-B3-C9;
A2-B3-C15;
A2-B3-C21;
A2-B3-C27;
A2-B3-C33;
A2-B3-C39;
A2-B3-C45; A3-B3-C5;
A3-B3-C11;
A3-B3-C17;
A3-B3-C23;
A3-B3-C29;
A3-B3-C35;
A3-B3-C41;
A4-B3-C1;
A4-B3-C7;
A4-B3-C13;
A4-B3-C19;
A4-B3-C25;
A4-B3-C31;
A4-B3-C37;
A4-B3-C43;
A5-B3-C3;
A5-B3-C9;
A5.-B3-C15;
A5-B3-C21;
A5-B3-C27;
A5-B3-C33;
A5-B3-C39;
A5-B3-C45;
A6-B3-C5;
A6-B3-C11;
A6-B3-C17;
A6-B3-C23;
A6-B3-C29;
A6-B3-C35;
A6-B3-C41;
A7-B3-C1;
A7-B3-C7;
A7-B3-C13;
A7-B3-C19;
A7-B3-C25;
A7-B3-C31;
A7-B3-C37;
A7-B3-C43;
A8-B3-C3;
A8-B3-C9;
A8-B3-C15;
A8-B3-C21;
A8-B3-C27;
A8-B3-C33;
A8-B3-C39;
A8-B3-C45; A9-B3-C5;
A9-B3-C11;
A9-B3-C17;
A9-B3-C23;
A9-B3-C29;
A9-B3-C35;
A9-B3-C41;
A10-B3-C1;
A1-B3-C44; A2-B3-C4;
A2-B3-C10;
A2-B3-C16;
A2-B3-C22;
A2-B3-C28;
A2-B3-C34;
A2-B3-C40;
A2-B3-C46; A3-B3-C6;
A3-B3-C12;
A3-B3-C18;
A3-B3-C24;
A3-B3-C30;
A3-B3-C36;
A3-B3-C42;
A4-B3-C2;
A4-B3-C8;
A4-B3-C14;
A4-B3-C20;
A4-B3-C26;
A4-B3-C32;
A4-B3-C38;
A4-B3-C44; A5-B3-C4;
A5-B3-C10;
A5-B3-C16;
A5-B3-C22;
A5-B3-C28;
A5-B3-C34;
A5-B3-C40;
A5-B3-C46; A6-B3-C6;
A6-B3-C12;
A6-B3-C18;
A6-B3-C24;
A6-B3-C30;
A6-B3-C36;
A6-B3-C42;
A7-B3-C2;
A7-B3-C8;
A7-B3-C14;
A7-B3-C20;
A7-B3-C26;
A7-B3-C32;
A7-B3-C38;
A7-B3-C44;
A8-B3-C4;
A8-B3-C10;
A8-B3-C16;
A8-B3-C22;
A8-B3-C28;
A8-B3-C34;
A8-B3-C40;
A8-B3-C46; A9-B3-C6;
A9-B3-C12;
A9-B3-C18;
A9-B3-C24;
A9-B3-C30;
A9-B3-C36;
A9-B3-C42;
A10-B3-C2;
A1-B3-C45;
A2-B3-C5;
A2-B3-C11;
A2-B3-C17;
A2-B3-C23;
A2-B3-C29;
A2-B3-C35;
A2-B3-C41;
A3-B3-C1;
A3-B3-C7;
A3-B3-C13;
A3-B3-C19;
A3-B3-C25;
A3-B3-C31;
A3-B3-C37;
A3-B3-C43;
A4-B3-C3;
A4-B3-C9;
A4-B3-C15;
A4-B3-C21;
A4-B3-C27;
A4-B3-C33;
A4-B3-C39;
A4-B3-C45;
A5-B3-C5;
A5-B3-C11;
A5-B3-C17;
A5-B3-C23;
A5-B3-C29;
A5-B3-C35;
A5-B3-C41;
A6-B3-C1;
A6-B3-C7;
A6-B3-C13;
A6-B3-C19;
A6-B3-C25;
A6-B3-C31;
A6-B3-C37;
A6-B3-C43;
A7-B3-C3;
A7-B3-C9;
A7-B3-C15;
A7-B3-C21;
A7-B3-C27;
A7-B3-C33;
A7-B3-C39;
A7-B3-C45;
A8-B3-C5;
A8-B3-C11;
A8-B3-C17;
A8-B3-C23;
A8-B3-C29;
A8-B3-C35;
A8-B3-C41;
A9-B3-C1;
A9-B3-C7;
A9-B3-C13;
A9-B3-C19;
A9-B3-C25;
A9-B3-C31;
A9-B3-C37;
A9-B3-C43;
A10-B3-C3;
A1-B3-C46;
A2-B3-C6;
A2-B3-C12;
A2-B3-C18;
A2-B3-C24;
A2-B3-C30;
A2-B3-C36;
A2-B3-C42;
A3-B3-C2;
A3-B3-C8;
A3-B3-C14;
A3-B3-C20;
A3-B3-C26;
A3-B3-C32;
A3-B3-C38;
A3-B3-C44;
A4-B3-C4;
A4-B3-C10;
A4-B3-C16;
A4-B3-C22;
A4-B3-C28;
A4-B3-C34;
A4-B3-C40;
A4-B3-C46;
A5-B3-C6;
A5-B3-C12;
A5-B3-C18;
A5-B3-C24;
A5-B3-C30;
A5-B3-C36;
A5-B3-C42;
A6-B3-C2;
A6-B3-C8;
A6-B3-C14;
A6-B3-C20;
A6-B3-C26;
A6-B3-C32;
A6-B3-C38;
A6-B3-C44;
A7-B3-C4;
A7-B3-C10;
A7-B3-C16;
A7-B3-C22;
A7-B3-C28;
A7-B3-C34;
A7-B3-C40;
A7-B3-C46;
A8-B3-C6;
A8-B3-C12;
A8-B3-C18;
A8-B3-C24;
A8-B3-C30;
A8-B3-C36;
A8-B3-C42;
A9-B3-C2;
A9-B3-C8;
A9-B3-C14;
A9-B3-C20;
A9-B3-C26;
A9-B3-C32;
A9-B3-C38;
A9-B3-C44;
A10-B3-C4;
A10-B3-C5;
A10-B3-C11;
A10-B3-C17;
A10-B3-C23;
A10-B3-C29;
A10-B3-C35;
A10-B3-C41;
A11-B3-C1;
A11-B3-C7;
A11-B3-C13;
A11-B3-C19;
A11-B3-C25;
A11-B3-C31;
A11-B3-C37;
A11-B3-C43;
A12-B3-C3;
A12-B3-C9;
A12-B3-C15;
A12-B3-C21;
A12-B3-C27;
A12-B3-C33;
A12-B3-C39;
A12-B3-C45;
A13-B3-C5;
A13-B3-C11;
A13-B3-C17;
A13-B3-C23;
A13-B3-C29;
A13-B3-C35;
A13-B3-C41;
A14-B3-C1;
A14-B3-C7;
A14-B3-C13;
A14-B3-C19;
A14-B3-C25;
A14-B3-C31;
'A14-B3-C37;
A14-B3-C43;
A15-B3-C3;
A15-B3-C9;
A15-B3-C15;
A15-B3-C21;
A15-B3-C27;
A15-B3-C33;
A15-B3-C39;
A15-B3-C45; A16-B3-C5;
A16-B3-C11;
A16-B3-C17;
A16-B3-C23;
A16-B3-C29;
A16-B3-C35;
A16-B3-C41;
A17-B3-C1;
A17-B3-C7;
A17-B3-C13;
A17-B3-C19;
A17-B3-C25;
A17-B3-C31;
A17-B3-C37;
A17-B3-C43;
A18-B3-C3;
A18-B3-C9;
A10-B3-C6;
A10-B3-C12;
A10-B3-C18;
A10-B3-C24;
A10-B3-C30;
A10-B3-C36;
A10-B3-C42;
A11-B3-C2;
A11-B3-C8;
A11-B3-C14;
A11-B3-C20;
A11-B3-C26;
A11-B3-C32;
A11-B3-C38;
A11-B3-C44;
A12-B3-C4;
A12-B3-C10;
A12-B3-C16;
A12-B3-C22;
A12-B3-C28;
A12-B3-C34;
A12-B3-C40;
A12-B3-C46;
A13-B3-C6;
A13-B3-C12;
A13-B3-C18;
A13-B3-C24;
A13-B3-C30;
A13-B3-C36;
A13-B3-C42;
A14-B3-C2;
A14-B3-C8;
A14-B3-C14;
A14-B3-C20;
A14-B3-C26;
A14-B3-C32;
A14-B3-C38;
A14-B3-C44;
A15-B3-C4;
A15-B3-C10;
A15-B3-C16;
A15-B3-C22;
A15-B3-C28;
A15-B3-C34;
A15-B3-C40;
A15-B3-C46;
A16-B3-C6;
A16-B3-C12;
A16-B3-C18;
A16-B3-C24;
A16-B3-C30;
A16-B3-C36;
A16-B3-C42;
A17-B3-C2;
A17-B3-C8;
A17-B3-C14;
A17-B3-C20;
A17-B3-C26;
A17-B3-C32;
A17-B3-C38;
A17-B3-C44;
A18-B3-C4;
A18-B3-C10;
A10-B3-C7;
A10-B3-C13;
A10-B3-C19;
A10-B3-C25;
A10-B3-C31;
A10-B3-C37;
A10-B3-C43;
A11-B3-C3;
A11-B3-C9;
A11-B3-C15;
A11-B3-C21;
A11-B3-C27;
A11-B3-C33;
A11-B3-C39;
A11-B3-C45;
A12-B3-C5;
A12-B3-C11;
A12-B3-C17;
A12-B3-C23;
A12-B3-C29;
A12-B3-C35;
A12-B3-C41;
A13-B3-C1;
A13-B3-C7;
A13-B3-C13;
A13-B3-C19;
A13-B3-C25;
A13-B3-C31;
A13-B3-C37;
A13-B3-C43;
A14-B3-C3;
A14-B3-C9;
A14-B3-C15;
A14-B3-C21;
A14-B3-C27;
A14-B3-C33;
A14-B3-C39;
A14-B3-C45;
A15-B3-C5;
A15-B3-C11;
A15-B3-C17;
A15-B3-C23;
A15-B3-C29;
A15-B3-C35;
A15-B3-C41;
A16-B3-C1;
A16-B3-C7;
A16-B3-C13;
A16-B3-C19;
A16-B3-C25;
A16-B3-C31;
A16-B3-C37;
A16-B3-C43;
A17-B3-C3;
A17-B3-C9;
A17-B3-C15;
A17-B3-C21;
A17-B3-C27;
A17-B3-C33;
A17-B3-C39;
A17-B3-C45;
A18-B3-C5;
A18-B3-C11;
A10-B3-C8;
A10-B3-C14;
A10-B3-C20;
A10-B3-C26;
A10-B3-C32;
A10-B3-C38;
A10-B3-C44; A11-B3-C4;
A11-B3-C10 ;.
A11-B3-C16;
A11-B3-C22;
A11-B3-C28;
A11-B3-C34;
A11-B3-C40;
A11-B3-C46;
A12-B3-C6;
A12-B3-C12;
A12-B3-C18;
A12-B3-C24;
A12-B3-C30;
A12-B3-C36;
A12-B3-C42;
A13-B3-C2;
A13-B3-C8;
A13-B3-C14;
A13-B3-C20;
A13-B3-C26;
A13-B3-C32;
A13-B3-C38;
A13-B3-C44;
A14-B3-C4;
A14-B3-C10;
A14-B3-C16;
A14-B3-C22;
A14-B3-C28;
A14-B3-C34;
A14-B3-C40;
A14-B3-C46;
A15-B3-C6;
A15-B3-C12;
A15-B3-C18;
A15-B3-C24;
A15-B3-C30;
A15-B3-C36;
A15-B3-C42;
A16-B3-C2;
A16-B3-C8;
A16-B3-C14;
A16-B3-C20;
A16-B3-C26;
A16-B3-C32;
A16-B3-C38;
A16-B3-C44;
A17-B3-C4;
A17-B3-C10;
A17-B3-C16;
A17-B3-C22;
A17-B3-C28;
A17-B3-C34;
A17-B3-C40;
A17-B3-C46;
A18-B3-C6;
A18-B3-C12;
A10-B3-C9;
A10-B3-C15;
A10-B3-C21;
A10-B3-C27;
A10-B3-C33;
A10-B3-C39;
A10-33-C45;
A11-B3-C5;
A11-B3-C11;
A11-B3-C17;
A11-B3-C23;
A11-B3-C29;
A11-B3-C35;
A11-B3-C41;
A12-B3-C1;
A12-33-C7;
A12-33-C13;
A12-B3-C19;
A12-B3-C25;
A12-B3-C31;
A12-B3-C37;
A12-B3-C43;
A13-B3-C3;
A13-33-C9;
A13-B3-C15;
A13-B3-C21;
A13-B3-C27;
A13-B3-C33;
A13-B3-C39;
A13-33-C45;
A14-B3-C5;
A14-B3-C11;
A14-33-C17;
A14-B3-C23;
A14-B3-C29;
A14-B3-C35;
A14-33-C41;
A15-B3-C1;
A15-B3-C7;
A15-B3-C13;
A15-B3-C19;
A15-B3-C25;
A15-B3-C31;
A15-B3-C37;
A15-B3-C43;
A16-B3-C3;
A16-B3-C9;
A16-B3-C15;
A16-B3-C21;
A16-B3-C27;
A16-B3-C33;
A16-B3-C39;
A16-33-C45;
A17-B3-C5;
A17-B3-C11;
A17-B3-C17;
A17-B3-C23;
A17-B3-C29;
A17-B3-C35;
A17-B3-C41;
A18-B3-C1;
A18-B3-C7;
A18-B3-C13;
A10-B3-C10;
A10-B3-C16;
A10-B3-C22;
A10-B3-C28;
A10-B3-C34;
A10-B3-C40;
A10-B3-C46;
A11-B3-C6;
A11-B3-C12;
A11-B3-C18;
A11-B3-C24;
A11-B3-C30;
A11-B3-C36;
A11-B3-C42;
A12-33-C2;
A12-B3-C8;
A12-B3-C14;
A12-B3-C20;
A12-B3-C26;
A12-B3-C32;
A12-B3-C38;
A12-B3-C44;
A13-B3-C4;
A13-33-C10;
A13-B3-C16;
A13-33-C22;
A13-33-C28;
A13-B3-C34;
A13-B3-C40;
A13-33-C46;
A14-B3-C6;
A14-B3-C12;
A14-33-C18;
A14-33-C24;
A14-B3-C30;
A14-B3-C36;
A14-B3-C42;
A15-B3-C2;
A15-33-C8;
A15-B3-C14;
A15-B3-C20;
A15-B3-C26;
A15-33-C32;
A15-B3-C38;
A15-B3-C44;
A16-B3-C4;
A16-B3-C10;
A16-B3-C16;
A16-B3-C22;
A16-B3-C28;
A16-B3-C34;
A16-33-C40;
A16-B3-C46;
A17-33-C6;
A17-B3-C12;
A17-B3-C18;
A17-B3-C24;
A17-B3-C30;
A17-B3-C36;
A17-B3-C42;
A18-B3-C2;
A18-B3-C8;
A18-33-C14;
A18-B3-C15;
A18-B3-C21;
A18-B3-C27;
A18-B3-C33;
A18-B3-C39;
A18-B3-C45;
A19-B3-C5;
A19-B3-C11;
A19-B3-C17;
A19-B3-C23;
A19-B3-C29;
A19-B3-C35;
A19-B3-C41;
A20-B3-C1;
A20-B3-C7;
A20-B3-C13;
A20-B3-C19;
A20-B3-C25;
A20-B3-C31;
A20-B3-C37;
A20-B3-C43;
A21-B3-C3;
A21-B3-C9;
A21-B3-C15;
A21-B3-C21;
A21-B3-C27;
A21-B3-C33;
A21-B3-C39;
A21-B3-C45;
A22-B3-C5;
A22-B3-C11;
A22-B3-C17;
A22-B3-C23;
A22-B3-C29;
A22-B3-C35;
A22-B3-C41;
A23-B3-C1;
A23-B3-C7;
A23-B3-C13;
A23-B3-C19;
A23-B3-C25;
A23-B3-C31;
A23-B3-C37;
A23-B3-C43;
A24-B3-C3;
A24-B3-C9;
A24-B3-C15;
A24-B3-C21;
A24-B3-C27;
A24-B3-C33;
A24-B3-C39;
A24-B3-C45;
A25-B3-C5;
A25-B3-C11;
A25-B3-C17;
A25-B3-C23;
A25-B3-C29;
A25-B3-C35;
A25-B3-C41;
A26-B3-C1;
A26-B3-C7;
A26-B3-C13;
A26-B3-C19;
A18-B3-C16;
A18-B3-C22;
A18-B3-C28;
A18-B3-C34;
A18-B3-C40;
A18-B3-C46;
A19-B3-C6;
A19-B3-C12;
A19-B3-C18;
A19-B3-C24;
A19-B3-C30;
A19-B3-C36;
A19-B3-C42;
A20-B3-C2;
A20-B3-C8;
A20-B3-C14;
A20-B3-C20;
A20-B3-C26;
A20-B3-C32;
A20-B3-C38;
A20-B3-C44;
A21-B3-C4;
A21-B3-CI0;
A21-B3-C16;
A21-B3-C22;
A21-B3-C28;
A21-B3-C34;
A21-B3-C40;
A21-B3-C46;
A22-B3-C6;
A22-B3-C12;
A22-B3-C18;
A22-B3-C24;
A22-B3-C30;
A22-B3-C36;
A22-B3-C42;
A23-B3-C2;
A23-B3-C8;
A23-B3-C14;
A23-B3-C20;
A23-B3-C26;
A23-B3-C32;
A23-B3-C38;
A23-B3-C44;
A24-B3-C4;
A24-B3-C10;
A24-B3-C16;
A24-B3-C22;
A24-B3-C28;
A24-B3-C34;
A24-B3-C40;
A24-B3-C46;
A25-B3-C6;
A25-B3-C12;
A25-B3-C18;
A25-B3-C24;
A25-B3-C30;
A25-B3-C36;
A25-B3-C42;
A26-B3-C2;
A26-B3-C8;
A26-B3-C14;
A26-B3-C20;
A18-B3-C17;
A18-B3-C23;
A18-B3-C29;
A18-B3-C35;
A18-B3-C41;
A19-B3-C1;
A19-B3-C7;
A19-B3-C13;
A19-B3-C19;
A19-B3-C25;
A19-B3-C31;
A19-B3-C37;
A19-B3-C43;
A20-B3-C3;
A20-B3-C9;
A20-B3-C15;
A20-B3-C21;
A20-B3-C27;
A20-B3-C33;
A20-B3-C39;
A20-B3-C45;
A21-B3-C5;
A21-B3-C11;
A21-B3-C17;
A21-B3-C23;
A21-B3-C29;
A21-B3-C35;
A21-B3-C41;
A22-B3-C1;
A22-B3-C7;
A22-B3-C13;
A22-B3-C19;
A22-B3-C25;
A22-B3-C31;
A22-B3-C37;
A22-B3-C43;
A23-B3-C3;
A23-B3-C9;
A23-B3-C15;
A23-B3-C21;
A23-B3-C27;
A23-B3-C33;
A23-B3-C39;
A23-B3-C45; A24-B3-C5;
A24-B3-C11;
A24-B3-C17;
A24-B3-C23;
A24-B3-C29;
A24-B3-C35;
A24-B3-C41;
A25-B3-C1;
A25-B3-C7;
A25-B3-C13;
A25-B3-C19;
A25-B3 -C 25;
A25-B3-C31;
A25-B3-C37;
A25-B3-C43;
A26-B3-C3;
A26-B3-C9;
A26-B3-C15;
A26-B3-C21;
A18-B3-C18;
A18-B3-C24;
A18-B3-C30;
A18-B3-C36;
A18-B3-C42;
A19-B3-C2;
A19-B3-C8;
A19-B3-C14;
A19-B3-C20;
A19-B3-C26;
A19-B3-C32;
A19-B3-C38;
A19-B3-C44; A20-B3-C4;
A20-B3-C10;
A20-B3-C16;
A20-B3-C22;
A20-B3-C28;
A20-B3-C34;
A20-B3-C40;
A20-B3-C46;
A21-B3-C6;
A21-B3-C12;
A21-B3-C18;
A21-B3-C24;
A21-B3-C30;
A21-B3-C36;
A21-B3-C42;
A22-B3-C2,
A22-B3-C8;
A22-B3-C14;
A22-B3-C20;
A22-B3-C26;
A22-B3-C32;
A22-B3-C38;
A22-B3-C44;
A23-B3-C4;
A23-B3-C10;
A23-B3-C16;
A23-B3-C22;
A23-B3-C28;
A23-B3-C34;
A23-B3-C40;
A23-B3-C46; A24-B3-C6;
A24-B3-C12;
A24-B3-C18;
A24-B3-C24;
A24-B3-C30;
A24-B3-C36;
A24-B3-C42;
A25-B3-C2;
A25-B3-C8;
A25-B3-C14;
A25-B3-C20;
A25-B3-C26;
A25-B3-C32;
A25-B3-C38;
A25-B3-C44; A26-B3-C4;
A26-B3-C10;
A26-B3-C16;
A26-B3-C22;
A18-B3-C19;
A18-B3-C25;
A18-B3-C31;
A18-B3-C37;
A18-B3-C43;
A19-B3-C3;
A19-B3-C9;
A19-B3-C15;
A19-B3-C21;
A19-B3-C27;
A19-B3-C33;
A19-B3-C39;
A19-B3-C45; A20-B3-C5;
A20-B3-C11;
A20-B3-C17;
A20-B3-C23;
A20-B3-C29;
A20-B3-C35;
A20-B3-C41;
A21-B3-C1;
A21-B3-C7;
A21-B3-C13;
A21-B3-C19;
A21-B3-C25;
A21-E3-C31;
A21-B3-C37;
A21-B3-C43;
A22-B3-C3;
A22-B3-C9;
A22-B3-C15;
A22-B3-C21;
A22-B3-C27;
A22-B3-C33;
A22-B3-C39;
A22-B3-C45; A23-B3-C5;
A23-B3-C11;
A23-B3-C17;
A23-B3-C23;
A23-B3-C29;
A23-B3-C35;
A23-B3-C41;
A24-B3-C1;
A24-B3-C7;
A24-B3-C13;
A24-B3-C19;
A24-B3-C25;
A24-B3-C31;
A24-B3-C37;
A24-B3-C43;
A25-B3-C3;
A25-B3-C9;
A25-B3-C15;
A25-B3-C21;
A25-B3-C27;
A25-B3-C33;
A25-B3-C39;
A25-B3-C45;
A26-B3-C5;
A26-B3-C11;
A26-B3-C17;
A26-B3-C23;
A18-B3-C20;
A18-B3-C26;
A18-B3-C32;
A18-B3-C38;
A18-B3-C44;
A19-B3-C4;
A19-B3-C10;
A19-B3-C16;
A19-B3-C22;
A19-B3-C28;
A19-B3-C34;
A19-B3-C40;
A19-B3-C46;
A20-B3-C6;
A20-B3-C12;
A20-B3-C18;
A20-B3-C24;
A20-B3-C30;
A20-B3-C36;
A20-B3-C42;
A21-B3-C2;
A21-B3-C8;
A21-B3-C14;
A21-B3-C20;
A21-B3-C26;
A21-B3-C32;
A21-B3-C38;
A21-B3-C44;
A22-B3-C4;
A22-B3-C10;
A22-B3-C16;
A22-53-C22;
A22-B3-C28;
A22-B3-C34;
A22-B3-C40;
A22-B3-C46; A23-B3-C6;
A23-B3-C12;
A23-B3-C18;
A23-B3-C24;
A23-B3-C30;
A23-B3-C36;
A23-B3-C42;
A24-B3-C2;
A24-B3-C8;
A24-B3-C14;
A24-B3-C20;
A24-B3-C26;
A24-B3-C32;
A24-B3-C38;
A24-B3-C44; A25-B3-C4;
A25-B3-C10;
A25-B3-C16;
A25-B3-C22;
A25-B3-C28;
A25-B3-C34;
A25-B3-C40;
A25-B3-C46;
A26-B3-C6;
A26-B3-C12;
A26-B3-C18;
A26-B3-C24;
A26-B3-C25;
A26-B3-C31;
A26-B3-C37;
A26-B3-C43;
A27-B3-C3;
A27-B3-C9;
A27-B3-C15;
A27-B3-C21;
A27-B3-C27;
A27-B3-C33;
A27-B3-C39;
A27-B3-C45;
A28-B3-C5;
A28-B3-C11;
A28-B3-C17;
A28-B3-C23;
A28-B3-C29;
A28-B3-C35;
A28-B3-C41;
A1-B4-C1;
A1-B4-C7;
A1-B4-C13;
A1-B4-C19;
A1-B4-C25;
A1-B4-C31;
A1-B4-C37;
A1-B4-C43;
A2-B4-C3;
A2-B4-C9;
A2-B4-C15;
A2-B4-C21;
A2-B4-C27;
A2-B4-C33;
A2-B4-C39;
A2-B4-C45;
A3-B4-C5;
A3-B4-C11;
A3-B4-C17;
A3-B4-C23;
A3-B4-C29;
A3-B4-C35;
A3-B4-C41;
A4-B4-C1;
A4-B4-C7;
A4-B4-C13;
A4-B4-C19;
A4-B4-C25;
A4-B4-C31;
A4-B4-C37;
A4-B4-C43;
A5-B4-C3;
A5-B4-C9;
A5-B4-C15;
A5-B4-C21;
A5-B4-C27;
A5-B4-C33;
A5-B4-C39;
A5-B4-C45;
A6-B4-C5;
A6-B4-C11;
A6-B4-C17;
A6-B4-C23;
A6-B4-C29;
A26-B3-C26;
A26-B3-C32; A26-B3-C38; A26-B3-C44;
A27-B3-C4;
A27-B3-C10;
A27-B3-C16;
A27-B3-C22;
A27-B3-C28;
A27-B3-C34;
A27-B3-C40;
A27-B3-C46;
A28-B3-C6;
A28-B3-C12;
A28-B3-C18;
A28-B3-C24;
A28-B3-C30;
A28-B3-C36;
A28-B3-C42;
A1-B4-C2;
A1-B4-C8;
A1-B4-C14;
A1-B4-C20;
A1-B4-C26;
A1-B4-C32;
A1-B4-C38;
A1-B4-C44;
A2-B4-C4;
A2-B4-C10;
A2-B4-C16;
A2-B4-C22;
A2-B4-C28;
A2-B4-C34;
A2-B4-C40;
A2-B4-C46;
A3-B4-C6;
A3-B4-C12;
A3-B4-C18; A3-B4-C24;
A3-B4-C30;
A3-B4-C36;
A3-B4-C42;
A4-B4-C2;
A4-B4-C8;
A4-B4-C14;
A4-B4-C2O;
A4-B4-C26;
A4-B4-C32; '
A4-B4-C38;
A4-B4-C44;
A5-B4-C4;
A5-B4-C1O;
A5-B4-C16;
A5-B4-C22;
B4-A5-C28;
A5-B4-C34;
A5-B4-C4O;
A5-B4-C46;
A6-B4-C6;
A6-B4-C12;
A6-B4-C18;
A6-B4-C24;
A6-B4-C30;
A26-B3-C27;
A26-B3-C33;
A26-B3-C39;
A26-B3-C45;
A27-B3-C5;
A27-B3-C11;
A27-B3-C17;
A27-B3-C23;
A27-B3-C29;
A27-B3-C35;
A27-B3-C41;
A28-B3-C1;
A28-B3-C7;
A28-B3-C13;
A28-B3-C19;
A28-B3-C25;
A28-B3-C31;
A28-B3-C37;
A28-B3-C43;
A1-B4-C3;
A1-B4-C9;
A1-B4-C15;
A1-B4-C21;
A1-B4-C27;
A1-B4-C33;
A1-B4-C39;
A1-B4-C45;
A2-B4-C5;
A2-B4-C11;
A2-B4-C17;
A2-B4-C23;
A2-B4-C29;
A2-B4-C35;
A2-B4-C41;
A3-B4-C1;
A3-B4-C7;
A3-B4-C13;
A3-B4-C19;
A3-B4-C25;
A3-B4-C31;
A3-B4-C37;
A3-B4-C43;
A4-B4-C3;
A4-B4-C9;
A4-B4-C15;
A4-B4-C21;
A4-B4-C27;
A4-B4-C33;
A4-B4-C39;
A4-B4-C45;
A5-B4-C5;
A5-B4-C11;
A5-B4-C17;
A5-B4-C23;
A5-B4-C29;
A5-B4-C35;
A5-B4-C41;
A6-B4-C1;
A6-B4-C7;
A6-B4-C13;
A6-B4-C19;
A6-B4-C25;
A6-B4-C31;
A26-B3-C28;
A26-B3-C34;
A26-B3-C40;
A26-B3-C46; A27-B3-C6;
A27-B3-C12;
A27-B3-C18;
A27-B3-C24;
A27-B3-C30;
A27-B3-C36;
A27-B3-C42;
A28-B3-C2;
A28-B3-C8;
A28-B3-C14;
A28-B3-C20;
A28-B3-C26;
A28-B3-C32;
A28-B3-C38;
A28-B3-C44;
A1-B4-C4;
A1-B4-C10;
A1-B4-C16;
A1-B4-C22;
A1-B4-C28;
A1-B4-C34;
A1-B4-C40;
A1-B4-C46;
A2-B4-C6;
A2-B4-C12;
A2-B4-C18;
A2-B4-C24;
A2-B4-C30;
A2-B4-C36;
A2-B4-C42;
A3-B4-C2;
A3-B4-C8;
A3-B4-C14;
A3-B4-C20;
A3-B4-C26;
A3-B4-C32;
A3-B4-C38;
A3-B4-C44;
A4-B4-C4;
A4-B4-C10;
A4-B4-C16;
A4-B4-C22;
A4-B4-C28;
A4-B4-C34;
A4-B4-C40;
A4-B4-C46;
A5-B4-C6;
A5-B4-C12;
A5-B4-C18; A5-B4-C24;
A5-B4-C30;
A5-B4-C36;
A5-B4-C42;
A6-B4-C2;
A6-B4-C8;
A6-B4-C14;
A6-B4-C20;
A6-B4-C26;
A6-B4-C32;
A26-B3-C29;
A26-B3-C35;
A26-B3-C41;
A27-B3-C1;
A27-B3-C7;
A27-B3-C13;
A27-B3-C19;
A27-B3-C25;
A27-B3-C31;
A27-B3-C37;
A27-B3-C43;
A28-B3-C3;
A28-B3-C9;
A28-B3-C15;
A28-B3-C21;
A28-B3-C27;
A28-B3-C33;
A28-B3-C39;
A28-B3-C45;
A1-B4-C5;
A1-B4-C11;
A1-B4-C17;
A1-B4-C23;
A1-B4-C29;
A1-B4-C35;
A1-B4-C41;
A2-34-C1;
A2-B4-C7;
A2-B4-C13;
A2-B4-C19;
A2-B4-C25;
A2-B4-C31;
A2-34-C37;
A2-B4-C43;
A3-34-C3;
A3-B4-C9;
A3-34-C15;
A3-34-C21;
A3-B4-C27;
A3-B4-C33;
A3-B4-C39;
A3-B4-C45;
A4-34-C5;
A4-B4-C11;
A4-34-C17;
A4-34-C23;
A4-34-C29;
A4-34-C35;
A4-34-C41;
A5-B4-C1;
A5-34-C7;
A5-B4-C13;
A5-B4-C19;
A5-34-C25;
A5-B4-C31;
A5-B4-C37;
A5-B4-C43;
A6-B4-C3;
A6-B4-C9;
A6-B4-C15;
A6-B4-C21;
A6-B4-C27;
A6-B4-C33;
A26-B3-C30;
A26-B3-C36;
A26-B3-C42;
A27-B3-C2;
A27-B3-C8;
A27-B3-C14;
A27-B3-C20;
A27-B3-C26;
A27-B3-C32;
A27-B3-C38;
A27-B3-C44;
A28-B3-C4;
A28-B3-C10;
A28-B3-C16;
A28-B3-C22;
A28-B3-C28;
A28-B3-C34;
A28-B3-C40;
A28-B3-C46;
A1-B4-C6;
A1-B4-C12;
A1-B4-C18;
A1-B4-C24;
A1-B4-C30;
A1-B4-C36;
A1-B4-C42;
A2-B4-C2;
A2-B4-C8;
A2-B4-C14;
A2-B4-C20;
A2-B4-C26;
A2-B4-C32;
A2-B4-C38;
A2-B4-C44;
A3-B4-C4;
A3-B4-C10;
A3-B4-C16;
A3-B4-C22;
A3-B4-C28;
A3-B4-C34;
A3-B4-C4O;
A3-B4-C46;
A4-B4-C6;
A4-B4-C12;
A4-B4-C18; A4-B4-C24;
A4-B4-C3o;
A4-B4-C36;
A4-B4-C42;
A5-B4-C2;
A5-B4-C8;
A5-B4-C14;
A5-B4-C20;
A5-B4-C26;
A5-B4-C32;
A5-B4-C38;
A5-B4-C44;
A6-B4-C4;
A6-B4-C10;
A6-B4-C16;
A6-B4-C22;
A6-B4-C28;
A6-B4-C34;
A6-B4-C35;
A6-B4-C41;
A7-B4-C1;
A7-B4-C7;
A7-B4-C13;
A7-B4-C19;
A7-B4-C25;
A7-B4-C31;
A7-B4-C37;
A7-B4-C43;
A8-B4-C3;>
A8-B4-C9;
A8-B4-C15;
A8-B4-C21;
A8-B4-C27;
A8-B4-C33;
The A8-B4-C39;
A8-B4-C45;
A9-B4-C5;
A9-B4-C11;
A9-B4-C17;
A9-B4-C23;
A9-B4-C29;
A9-B4-C35;
A9-B4-C41;
A10-B4-C1;
A10-B4-C7;
A10-B4-C13;
A10-B4-C19;
A10-B4-C25;
A10-B4-C31;
A10-B4-C37;
A10-B4-C43;
A11-B4-C3;
A11-B4-C9;
A11-B4-C15;
A11-B4-C21;
A11-B4-C27;
A11-B4-C33;
A11-B4-C39;
A11-B4-C45;
A12-B4-C5;
A12-B4-C11;
A12-B4-C17;
A12-B4-C23;
A12-B4-C29;
A12-B4-C35;
A12-B4-C41;
A13-B4-C1;
A13-B4-C7;
A13-B4-C13;
A13-B4-C19;
A13-B4-C25;
A13-B4-C31;
A13-B4-C37;
A13-B4-C43;
A14-B4-C3;
A14-B4-C9;
A14-B4-C15;
A14-B4-C21;
A14-B4-C27;
A14-B4-C33;
A14-B4-C39;
A6-B4-C36;
A6-B4-C42;
A7-B4-C2;
A7-B4-C8;
A7-B4-C14;
A7-B4-C20;
A7-B4-C26;
A7-B4-C32;
A7-B4-C38;
A7-B4-C44;
A8-B4-C4;
A8-B4-C10;
A8-B4-C16;
A8-B4-C22;
A8-B4-C28; A8-B4-C34;
A8-B4-C40;
A8-B4-C46;
A9-B4-C6;
A9-B4-C12;
A9-B4-C18;
? 9 B4-C24;
A9-B4-C30;
A9-B4-C36;
A9-B4-C42;
A10-B4-C2;
A10-B4-C8;
A1O-B4-C14;
A10-B4-C20;
A10-B4-C26;
A10-B4-C32;
A10-B4-C38;
A10-B4-C44;
A11-B4-C4;
A11-B4-C10;
A11-B4-C16;
A11-B4-C22;
A11-B4-C28;
A11-B4-C34;
A11-B4-C40;
A11-B4-C46;
A12-B4-C6;
A12-B4-C12;
A12-B4-C18;
A12-B4-C24;
A12-B4-C30;
A12-B4-C36;
A12-B4-C42;
A13-B4-C2;
A13-B4-C8;
A13-B4-C14;
A13-B4-C20;
A13-B4-C26;
A13-B4-C32;
A13-B4-C38;
A13-B4-C44; A14-B4-C4;
A14-B4-C10;
A14-B4-C16;
A14-B4-C22;
A14-B4-C28;
A14-B4-C34;
A14-B4-C4O;
A6-B4-C37;
A6-B4-C43;
A7-B4-C3;
A7-B4-C9;
A7-B4-C15;
A7-B4-C21;
A7-B4-C27;
A7-B4-C33;
A7-B4-C39;
A7-B4-C45;
A8-B4-C5;
A8-B4-C11;
A8-B4-C17;
A8-B4-C23;
A8-B4-C29;
A8-B4-C35;
A8-B4-C41;
A9-B4-C1;
A9-B4-C7;
A9-B4-C13;
A9-B4-C19;
A9-B4-C25;
A9-B4-C31;
A9-B4-C37;
A9-B4-C43;
A10-B4-C3;
A10-B4-C9;
A10-B4-C15;
A1O-B4-C2I;
A10-B4-C27;
A10-B4-C33;
A10-B4-C39;
A10-B4-C45;
A11-B4-C5;
A11-B4-C11;
A11-B4-C17;
A11-B4-C23;
A11-B4-C29;
A11-B4-C35;
A11-B4-C41;
A12-B4-C1;
A12-B4-C7;
A12-B4-C13;
A12-B4-C19;
A12-B4-C25;
A12-B4-C31;
A12-B4-C37;
A12-B4-C43;
A13-B4-C3;
A13-B4-C9;
A13-B4-C15;
A13-B4-C21;
A13-B4-C27;
A13-B4-C33;
A13-B4-C39;
A13-B4-C45;
A14-B4-C5;
A14-B4-C11;
A14-B4-C17;
A14-B4-C23;
A14-B4-C29;
A14-B4-C35;
A14-B4-C41;
A6-B4-C38; A6-B4-C44; A7-B4-C4;
A7-B4-C10;
A7-B4-C16;
A7-B4-C22;
A7-B4-C28;
A7-B4-C34;
A7-B4-C40;
A7-B4-C46;
A8-B4-C6;
A8-B4-C12;
A8-B4-C18;
A8-B4-C24;
A8-B4-C30;
A8-B4-C36;
A8-B4-C42;
A9-B4-C2;
A9-B4-C8;
A9-B4-C14;
A9-B4-C20;
A9-B4-C26;
A9-B4-C32;
A9-B4-C38;
A9-B4-C44;
A10-B4-C4;
A10-B4-C10;
A10-B4-C16;
A10-B4-C22;
A10-B4-C28;
A10-B4-C34;
A10-B4-C40;
A10-B4-C46;
A11-B4-C6;
A11-B4-C12;
A11-B4-C18;
A11-B4-C24;
A11-B4-C30;
A11-B4-C36;
A11-B4-C42;
A12-B4-C2;
A12-B4-C8;
A12-B4-C14;
A12-B4-C20;
A12-B4-C26;
A12-B4-C32;
A12-B4-C38;
A12-B4-C44; A13-B4-C4;
A13-B4-C10;
A13-B4-C16;
A13-B4-C22;
A13-B4-C28;
A13-B4-C34;
A13-B4-C40;
A13-B4-C46; A14-B4-C6;
A14-B4-C12;
A14-B4-C18;
A14-B4-C24;
A14-B4-C30;
A14-B4-C36;
A14-B4-C42;
A6-B4-C39;
A6-B4-C45;
A7-B4-C5;
A7-B4-C11;
A7-B4-C17;
A7-B4-C23;
A7-B4-C29;
A7-B4-C35;
A7-B4-C41;
A8-B4-C1;
A8-B4-C7;
A8-B4-C13;
A8-B4-C19;
A8-B4-C25;
A8-B4-C31;
A8-B4-C37;
A8-B4-C43;
A9-B4-C3;
A9-B4-C9;
A9-B4-C15;
A9-B4-C21;
A9-B4-C27;
A9-B4-C33;
A9-B4-C39;
A9-B4-C45;
A10-B4-C5;
A10-B4-C11;
A10-B4-C17;
A10-B4-C23;
A10-B4-C29;
A10-B4-C35;
A10-B4-C41;
A11-B4-C1;
A11-B4-C7;
A11-B4-C13;
A11-B4-C19;
A11-B4-C25;
A11-B4-C31;
AU-B4-C37;
A11-B4-C43;
A12-B4-C3;
A12-B4-C9;
A12-B4-C15;
A12-B4-C21;
A12-B4-C27;
A12-B4-C33;
A12-B4-C39;
A12-B4-C45;
A13-B4-C5;
A13-B4-C11;
A13-B4-C17;
A13-B4-C23;
A13-B4-C29;
A13-B4-C35;
A13-B4-C41;
A14-B4-C1;
A14-B4-C7;
A14-B4-C13;
A14-B4-C19;
A14-B4-C25;
A14-B4-C31;
A14-B4-C37;
A14-B4-C43;
A6-B4-C40;
A6-B4-C46; A7-B4-C6; A7-B4-C12; A7-B4-C18; A7-B4-C24; A7-B4-C30; A7-B4-C36; A7-B4-C42; A8-B4-C2;
A8-B4-C8;
A8-B4-C14; A8-B4-C20; A8-B4-C26; A8-B4-C32; A8-B4-C38; A8-B4-C44; A9-B4-C4; A9-B4-C10; A9-B4-C16; A9-B4-C22; A9-B4-C28; A9-B4-C34; A9-B4-C40; A9-B4-C46;
A10-B4-C6;
A10-B4-C12; A10-B4-C18; A10-B4-C24; A10-B4-C30; A10-B4-C36; A10-B4-C42; A11-B4-C2; A11-B4-C8;
A11-B4-C14; A11-B4-C20; A11-B4-C26; A11-B4-C32; A11-B4-C38; A11-B4-C44; A12-B4-C4;
A12-B4-C10;
A12-B4-C16;
A12-B4-C22; A12-B4-C28; A12-B4-C34; A12-B4-C40; A12-B4-C46; A13-B4-C6;
A13-B4-C12;
A13-B4-C18;
A13-B4-C24; A13-B4-C30; A13-B4-C36; A13-B4-C42; A14-B4-C2; A14-B4-C8;
A14-B4-C14;
A14-B4-C20;
A14-B4-C26;
A14-B4-C32;
A14-B4-C38;
A14-B4-C44;
A14-B4-C45;
A15-B4-C5;
A15-B4-C11;
A15-B4-C17;
A15-B4-C23;
A15-B4-C29;
A15-B4-C35;
A15-B4-C41;
A16-B4-C1;
A16-B4-C7;
A16-B4-C13;
A16-B4-C19;
A16-B4-C25;
A16-B4-C31;
A16-B4-C37;
A16-B4-C43;
A17-B4-C3;
A17-B4-C9;
A17-B4-C15;
A17-B4-C21;
A17-B4-C27;
A17-B4-C33;
A17-B4-C39;
A17-B4-C45;
A18-B4-C5;
A18-B4-C11;
A18-B4-C17;
A18-B4-C23;
A18-B4-C29;
A18-B4-C35;
A18-B4-C41;
A19-B4-C1;
A19-B4-C7;
A19-B4-C13;
A19-B4-C19;
A19-B4-C25;
A19-B4-C31;
A19-B4-C37;
A19-B4-C43;
A20-B4-C3;
A20-B4-C9;
A20-B4-C15;
A20-B4-C21;
A20-B4-C27;
A20-B4-C33;
A20-B4-C39;
A20-B4-C45;
A21-B4-C5;
A21-B4-C11;
A21-B4-C17;
A21-B4-C23;
A21-B4-C29;
A21-B4-C35;
A21-B4-C41;
A22-B4-C1;
A22-B4-C7;
A22-B4-C13;
A22-B4-C19;
A22-B4-C25;
A22-B4-C31;
A22-B4-C37;
A22-B4-C43;
A23-B4-C3;
A14-B4-C46;
A15-B4-C6;
A15-B4-C12;
A15-B4-C18;
A15-B4-C24;
A15-B4-C30;
A15-B4-C36;
A15-B4-C42;
A16-B4-C2;
A16-B4-C8;
A16-B4-C14;
A16-B4-C20;
A16-B4-C26;
A16-B4-C32;
A16-B4-C38;
A16-B4-C44;
A17-B4-C4;
A17-B4-C10;
A17-B4-C16;
A17-B4-C22; A17-B4-C28; A17-B4-C34;
A17-B4-C40;
A17-B4-C46;
A18-B4-C6;
A18-B4-C12;
A18-B4-C18;
A18-B4-C24;
A18-B4-C30;
A18-B4-C36;
A18-B4-C42;
A19-B4-C2;
A19-B4-C8;
A19-B4-C14;
A19-B4-C20;
A19-B4-C26;
A19-B4-C32;
A19-B4-C38;
A19-B4-C44;
A20-B4-C4;
A20-B4-C10;
A20-B4-C16;
A20-B4-C22;
A20-B4-C28;
A20-B4-C34;
A20-B4-C40;
A20-B4-C46;
A21-B4-C6; ·
A21-B4-C12;
A21-B4-C18;
A21-B4-C24;
A21-B4-C30;
A21-B4-C36;
A21-B4-C42;
A22-B4-C2;
A22-B4-C8;
A22-B4-C14;
A22-B4-C20;
A22-B4-C26;
A22-B4-C32;
A22-B4-C38;
A22-B4-C44;
A23-B4-C4;
A15-B4-C1;
A15-B4-C7;
A15-B4-C13;
A15-B4-C19;
A15-B4-C25;
A15-B4-C31;
A15-B4-C37;
A15-B4-C43;
A16-B4-C3;
A16-B4-C9;
A16-B4-C15;
A16-B4-C21;
A16-B4-C27;
A16-B4-C33;
A16-B4-C39;
A16-B4-C45; A17-B4-C5;
A17-B4-C11;
A17-B4-C17;
A17-B4-C23;
A17-B4-C29;
A17-B4-C35;
A17-B4-C41;
A18-B4-C1;
A18-B4-C7;
A18-B4-C13;
A18-B4-C19;
A18-B4-C25;
A18-B4-C31;
A18-B4-C37;
A18-B4-C43;
A19-B4-C3;
A19-B4-C9;
A19-B4-C15;
A19-B4-C21;
A19-B4-C27;
A19-B4-C33;
A19-B4-C39;
A19-B4-C45; A20-B4-C5;
A20-B4-C11;
A20-B4-C17;
A20-B4-C23;
A20-B4-C29;
A20-B4-C35;
A20-B4-C41;
A21-B4-C1;
A21-B4-C7;
A21-B4-C13;
A21-B4-C19;
A21-B4-C25;
A21-B4-C31;
A21-B4-C37;
A21-B4-C43;
A22-B4-C3;
A22-B4-C9;
A22-B4-C15;
A22-B4-C21;
A22-B4-C27;
A22-B4-C33;
A22-B4-C39;
A22-B4-C45;
A23-B4-C5;
A15-B4-C2;
A15-B4-C8;
A15-B4-C14;
A15-B4-C20;
A15-B4-C26;
A15-B4-C32;
A15-B4-C38;
A15-B4-C44;
A16-B4-C4;
A16-B4-C10;
A16-B4-C16;
A16-B4-C22;
A16-B4-C28;
A16-B4-C34;
A16-B4-C40;
A16-B4-C46;
A17-B4-C6;
A17-B4-C12;
A17-B4-C18;
A17-B4-C24;
A17-B4-C30;
A17-B4-C36;
A17-B4-C42;
A18-B4-C2;
A18-B4-C8;
A18-B4-C14;
A18-B4-C20;
A18-B4-C26;
A18-B4-C32;
A18-B4-C38;
A18-B4-C44;
A19-B4-C4;
A19-B4-C10;
A19-B4-C16;
A19-B4-C22;
A19-B4-C28;
A19-B4-C34;
A19-B4-C40;
A19-B4-C46;
A20-B4-C6;
A20-B4-C12;
A20-B4-C18;
A20-B4-C24;
A20-B4-C30;
A20-B4-C36;
A20-B4-C42;
A21-B4-C2;
A21-B4-C8;
A21-B4-C14;
A21-B4-C20;
A21-B4-C26;
A21-B4-C32;
A21-B4-C38;
A21-B4-C44; A22-B4-C4;
A22-B4-C10;
A22-B4-C16;
A22-B4-C22;
A22-B4-C28;
A22-B4-C34;
A22-B4-C40;
A22-B4-C46;
A23-B4-C6;
A15-B4-C3;
A15-B4-C9;
A15-B4-C15;
A15-B4-C21;
A15-B4-C27;
A15-B4-C33;
A15-B4-C39;
A15-B4-C45; A16-B4-C5;
A16-B4-C11;
A16-B4-C17;
A16-B4-C23;
A16-B4-C29;
A16-B4-C35;
A16-B4-C41;
A17-B4-C1;
A17-B4-C7;
A17-B4-C13;
A17-B4-C19;
A17-B4-C25;
A17-B4-C31;
A17-B4-C37;
A17-B4-C43;
A18-B4-C3;
A18-B4-C9;
A18-B4-C15;
A18-B4-C21;
A18-B4-C27;
A18-B4-C33;
A18-B4-C39;
A18-B4-C45;
A19-B4-C5;
A19-B4-C11;
A19-B4-C17;
A19-B4-C23;
A19-B4-C29;
A19-B4-C35;
A19-B4-C41;
A20-B4-C1;
A20-B4-C7;
A20-B4-C13;
A20-B4-C19;
A20-B4-C25;
A20-B4-C31;
A20-B4-C37;
A20-B4-C43;
A21-B4-C3;
A21-B4-C9;
A21-B4-C15;
A21-B4-C21;
A21-B4-C27;
A21-B4-C33;
A21-B4-C39;
A21-B4-C45;
A22-B4-C5;
A22-B4-C11;
A22-B4-C17;
A22-B4-C23;
A22-B4-C29;
A22-B4-C35;
A22-B4-C41;
A23-B4-C1;
A23-B4-C7;
A15-B4-C4;
A15-B4-C10;
A15-B4-C16;
A15-B4-C22;
A15-B4-C28;
A15-B4-C34;
A15-B4-C40;
A15-B4-C46;
A16-B4-C6;
A16-B4-C12;
A16-B4-C18;
A16-B4-C24;
A16-B4-C30;
A16-B4-C36;
A16-B4-C42;
A17-B4-C2;
A17-B4-C8;
A17-B4-C14;
A17-B4-C20;
A17-B4-C26;
A17-B4-C32;
A17-B4-C38;
A17-B4-C44; A18-B4-C4;
A18-B4-C10;
A18-B4-C16;
A18-B4-C22;
A18-B4-C28;
A18-E4-C34;
A18-B4-C40;
A18-B4-C46;
A19-B4-C6;
A19-B4-C12;
A19-E4-C18;
A19-B4-C24;
A19-B4-C30;
A19-B4-C36;
A19-B4-C42;
A20-B4-C2;
A20-B4-C8;
A20-B4-C14;
A20-B4-C20;
A20-E4-C26;
A20-B4-C32;
A20-B4-C38;
A20-B4-C44;
A21-B4-C4;
A21-B4-C10;
A21-B4-C16;
A21-B4-C22;
A21-B4-C28;
A21-B4-C34;
A21-B4-C40;
A21-B4-C46;
A22-B4-C6;
A22-B4-C12;
A22-B4-C18;
A22-B4-C24;
A22-B4-C30;
A22-B4-C36;
A22-B4-C42;
A23-B4-C2;
A23-B4-C8;
A23-B4-C9;
A23-B4-C15;
A23-B4-C21;
A23-B4-C27;
A23-B4-C33;
A23-B4-C39;
A23-B4-C45; A24-B4-C5; A24-B4-C11; A24-B4-C17; A24-B4-C23; A24 B4--C 29; A24-B4-C35;
A24-B4-C41;
A25-B4-C1;
A25-B4-C7;
A25-B4-C13;
A25-B4-C19;
A25-B4-C25;
A25-B4-C31;
A25-B4-C37;
A25-B4-C43;
A26-B4-C3;
A26-B4-C9;
A26-B4-C15;
A26-B4-C21;
A26-B4-C27;
A26-B4-C33;
A26-B4-C39;
A26-B4-C45;
A27-B4-C5;
A27-B4-C11;
A27-B4-C17;
A27-B4-C23;
A27-B4-C29;
A27-B4-C35;
A27-B4-C41;
A28-B4-C1;
A28-B4-C7;
A28-B4-C13;
A28-B4-C19;
A28-B4-C25;
A28-B4-C31;
A28-B4-C37;
A28-B4-C43;
A1-B5-C3;
A1-B5-C9;
A1-B5-CI5;
A1-B5-C21;
A1-B5-C27;
A1-B5-C33;
A1-B5-C39;
A1-B5-C45;
A2-B5-C5;
A2-B5-C11;
A2-B5-C17;
A2-B5-C23;
A2-B5-C29;
A2-B5-C35;
A2-B5-C41;
A3-B5-C1;
A3-B5-C7;
A3-B5-C13;
A23-B4-C10;
A23-B4-C16;
A23-B4-C22;
A23-B4-C28;
A23-B4-C34;
A23-B4-C40;
A23-B4-C46;
A24-B4-C6;
A24-B4-C12;
A24-B4-C18;
A24-B4-C24;
A24-B4-C30;
A24-B4-C36;
A24-B4-C42;
A25-B4-C2;
A25-B4-C8;
A25-B4-C14;
A25-B4-C20;
A25-B4-C26;
A25-B4-C32;
A25-B4-C38;
A25-B4-C44;
A26-B4-C4;
A26-B4-C10;
A26-B4-C16;
A26-B4-C22;
A26-B4-C28;
A26-B4-C34;
A26-B4-C40;
A26-B4-C46;
A27-B4-C6;
A27-B4-C12;
A27-B4-C18;
A27-B4-C24;
A27-B4-C30;
A27-B4-C36;
A27-B4-C42;
A28-B4-C2;
A28-B4-C8;
A28-B4-C14;
A28-B4-C20;
A28-B4-C26;
A28-B4-C32;
A28-B4-C38;
A28-B4-C44;
A1-B5-C4;
A1-B5-C10;
A1-B5-C16; '
A1-B5-C22;
A1-B5-C28;
A1-B5-C34;
A1-B5-C4O;
A1-B5-C46;
A2-B5-C6;
A2-B5-C12;
A2-B5-C18;
A2-B5-C24;
A2-B5-C30;
A2-B5-C36;
A2-B5-C42;
A3-B5-C2;
A3-B5-C8;
A3-B5-C14;
A23-B4-C11;
A23-B4-C17;
A23-B4-C23;
A23-B4-C29;
A23-B4-C35;
A23-B4-C41;
A24-B4-C1;
A24-B4-C7;
A24-B4-C13;
A24-B4-C19;
A24-B4-C25;
A24-B4-C31;
A24-B4-C37;
A24-B4-C43;
A25-B4-C3;
A25-B4-C9;
A25-B4-C15;
A25-B4-C21;
A25-B4-C27;
A25-B4-C33;
A25-B4-C39;
A25-B4-C45;
A26-B4-C5;
A26-B4-C11;
A26-B4-C17;
A26-B4-C23;
A26-B4-C29;
A26-B4-C35;
A26-B4-C41;
A27-B4-C1;
A27-B4-C7;
A27-B4-C13;
A27-B4-C19;
A27-B4-C25;
A27-B4-C31;
A27-B4-C37;
A27-B4-C43;
A28-B4-C3;
A28-B4-C9;
A28-B4-C15;
A28-B4-C21;
A28-B4-C27;
A28-B4-C33;
A28-B4-C39;
A28-B4-C45; A1-B5-C5;
A1-B5-C11;
A1-B5-C17;
A1-B5-C23;
A1-B5-C29;
A1-B5-C35;
A1-B5-C41;
A2-B5-C1;
A2-B5-C7;
A2-B5-C13;
A2-B5-C19;
A2-B5-C25;
A2-B5-C31;
A2-B5-C37;
A2-B5-C43;
A3-B5-C3;
A3-B5-C9;
A3-B5-C15;
A23-B4-C12; A23-B4-C18; A23-B4-C24;
A23-B4-C30;
A23-B4-C36;
A23-B4-C42;
A24-B4-C2;
A24-B4-C8;
A24-B4-C14;
A24-B4-C20;
A24-B4-C26;
A24-B4-C32;
A24-B4-C38;
A24-B4-C44;
A25-B4-C4;
A25-B4-C10;
A25-B4-C16;
A25-B4-C22;
A25-B4-C28;
A25-B4-C34;
A25-B4-C40;
A25-B4-C46;
A26-B4-C6;
A26-B4-C12;
A26-B4-C18;
A26-B4-C24;
A26-B4-C30;
A26-B4-C36;
A26-B4-C42;
A27-B4-C2;
A27-B4-C8;
A27-B4-C14;
A27-B4-C20;
A27-B4-C26;
A27-B4-C32;
A27-B4-C38;
A27-B4-C44; A28-B4-C4;
A28-B4-C10;
A28-B4-C16;
A28-B4-C22;
A28-B4-C28;
A28-B4-C34;
A28-B4-C40;
A28-B4-C46;
A1-B5-C6;
A1-B5-C12;
A1-B5-C18;
A1-B5-C24;
A1-B5-C30;
A1-B5-C36;
A1-B5-C42;
A2-B5-C2;
A2-B5-C8;
A2-B5-C14;
A2-B5-C20;
A2-B5-C26;
A2-B5-C32;
A2-B5-C38;
A2-B5-C44;
A3-B5-C4;
A3-B5-C10;
A3-B5-C16;
A23-B4-C13;
A23-B4-C19;
A23-B4-C25;
A23-B4-C31;
A23-B4-C37;
A23-B4-C43;
A24-B4-C3;
A24-B4-C9;
A24-B4-C15;
A24-B4-C21;
A24-B4-C27;
A24-B4-C33;
A24-B4-C39;
A24-B4-C45;
A25-B4-C5;
A25-B4-C11;
A25-B4-C17;
A25-B4-C23;
A25-B4-C29;
A25-B4-C35;
A25-B4-C41;
A26-B4-C1;
A26-B4-C7;
A26-B4-C13;
A26-B4-C19;
A26-B4-C25;
A26-B.4-C31;
A26-B4-C37;
A26-B4-C43;
A27-B4-C3;
A27-B4-C9;
A27-B4-C15;
A27-B4-C21;
A27-B4-C27;
A27-B4-C33;
A27-B4-C39;
A27-B4-C45;
A28-B4-C5;
A28-B4-C11;
A28-B4-C17;
A28-B4-C23;
A28-B4-C29;
A28-B4-C35;
A28-B4-C41;
A1-B5-C1;
A1-B5-C7;
A1-B5-C13;
A1-B5-C19;
A1-B5-C25;
A1-B5-C31;
A1-B5-C37;
A1-B5-C43;
A2-B5-C3;
A2-B5-C9;
A2-B5-C15;
A2-B5-C21;
A2-B5-C27;
A2-B5-C33;
A2-B5-C39;
A2-B5-C45;
A3-B5-C5;
A3-B5-C11;
A3-B5-C17;
A23-B4-C14;
A23-B4-C20;
A23-B4-C26;
A23-B4-C32;
A23-B4-C38;
A23-B4-C44;
A24-B4-C4;
A24-B4-C10;
A24-B4-C16;
A24-B4-C22;
A24-B4-C28;
A24-B4-C34;
A24-B4-C40;
A24-B4-C46;
A25-B4-C6;
A25-B4-C12;
A25-B4-C18;
A25-B4-C24;
A25-B4-C30;
A25-B4-C36;
A25-B4-C42;
A26-B4-C2;
A26-B4-C8;
A26-B4-C14;
A26-B4-C20;
A26-B4-C26;
A26-B4-C32;
A26-B4-C38;
A26-B4-C44;
A27-B4-C4;
A27-B4-C10;
A27-B4-C16;
A27-B4-C22;
A27-B4-C28;
A27-B4-C34;
A27-B4-C40;
A27-B4-C46;
A28-B4-C6;
A28-B4-C12;
A28-B4-C18;
A28-B4-C24;
A28-B4-C30;
A28-B4-C36;
A28-B4-C42;
A1-B5-C2;
A1-B5-C8;
A1-B5-C14;
A1-B5-C20;
A1-B5-C26;
A1-B5-C32;
A1-B5-C38;
A1-B5-C44;
A2-B5-C4;
A2-B5-C10;
A2-B5-C16;
A2-B5-C22;
A2-B5-C28;
A2-B5-C34;
A2-B5-C40;
A2-B5-C46;
A3-B5-C6;
A3-B5-C12;
A3-B5-C18;
A3-B5-C19;
A3-B5-C25;
A3-B5-C31;
A3-B5-C37;
A3-B5-C43;
A4-B5-C3;
A4-B5-C9;
A4-B5-C15;
A4-B5-C21;
A4-B5-C27;
A4-B5-C33;
A4-B5-C39;
A4-B5-C45;
A5-B5-C5;
A5-B5-C11;
A5-B5-C17;
A5-B5-C23;
A5-B5-C29;
A5-B5-C35;
A5-B5-C41;
A6-B5-C1;
A6-B5-C7;
A6-B5-C13;
A6-B5-C19;
A6-B5-C25;
A6-B5-C31;
A6-B5-C37;
A6-B5-C43;
A7-B5-C3;
A7-B5-C9;
A7-B5-C15;
A7-B5-C21;
A7-B5-C27;
A7-B5-C33;
A7-B5-C39;
A7-B5-C45;
A8-B5-C5;
A8-B5-C11;
A8-B5-C17;
A8-B5-C23;
A8-B5-C29;
A8-B5-C35;
A8-B5-C41;
A9-B5-C1;
A9-B5-C7;
A9-B5-C13;
A9-B5-C19;
A9-B5-C25;
A9-B5-C31;
A9-B5-C37;
A9-B5-C43;
A10-B5-C3;
A10-B5-C9;
A10-B5-C15;
A10-B5-C21;
A10-B5-C27;
A10-B5-C33;
A10-B5-C39;
A10-B5-C45;
A11-B5-C5;
A11-B5-C11;
A11-B5-C17;
A11-B5-C23;
A3-B5-C20;
A3-B5-C26;
A3-B5-C32;
A3-B5-C38;
A3-B5-C44;
A4-B5-C4;
A4-B5-C10;
A4-B5-C16;
A4-B5-C22;
A4-B5-C28;
A4-B5-C34;
A4-B5-C40;
A4-B5-C46;
A5-B5-C6;
A5-B5-C12;
A5-B5-C18;
A5-B5-C24;
A5-B5-C30;
A5-B5-C36;
A5-B5-C42;
A6-B5-C2;
A6-B5-C8;
A6-B5-C14;
A6-B5-C20;
A6-B5-C26;
A6-B5-C32;
A6-B5-C38;
A6-B5-C44;
A7-B5-C4;
A7-B5-C10;
A7-B5-C16;
A7-B5-C22;
A7-B5-C28;
A7-B5-C34;
A7-B5-C40;
A7-B5-C46;
A8-B5-C6;
A8-B5-C12;
A8-B5-C18;
A8-B5-C24;
A8-B5-C30;
A8-B5-C36;
A8-B5-C42;
A9-B5-C2;
A9-B5-C8;
A9-B5-C14;
A9-B5-C20;
A9-B5-C26; '
A9-B5-C32;
A9-B5-C38;
A9-B5-C44;
A10-B5-C4;
A10-B5-C10;
A10-B5-C16;
A10-B5-C22;
A10-B5-C28;
A10-B5-C34;
A10-B5-C40;
A10-B5-C46;
A11-B5-C6;
A11-B5-C12;
A11-B5-C18;
A11-B5-C24;
A3-B5-C21;
A3-B5-C27;
A3-B5-C33;
A3-B5-C39;
A3-B5-C45;
A4-B5-C5;
A4-B5-C11;
A4-B5-C17;
A4-B5-C23;
A4-B5-C29;
A4-B5-C35;
A4-B5-C41;
A5-B5-C1;
A5-B5-C7;
A5-B5-C13;
A5-B5-C19;
A5-B5-C25;
A5-B5-C31;
A5-B5-C37;
A5-B5-C43;
A6-B5-C3;
A6-B5-C9;
A6-B5-C15;
A6-B5-C21;
A6-B5-C27;
A6-B5-C33;
A6-B5-C39;
A6-B5-C45;
A7-B5-C5;
A7-B5-C11;
A7-B5-C17;
A7-B5-C23;
A7-B5-C29;
A7-B5-C35;
A7-B5-C41;
A8-B5-C1;
A8-B5-C7;
A8-B5-C13;
A8-B5-C19;
A8-B5-C25;
A8-B5-C31;
A8-B5-C37;
A8-B5-C43;
A9-B5-C3;
A9-B5-C9;
A9-B5-C15;
A9-B5-C21;
A9-B5-C27;
A9-B5-C33;
A9-B5-C39;
A9-B5-C45;
A10-B5-C5;
A10-B5-C11;
A10-B5-C17;
A10-B5-C23;
A10-B5-C29;
A10-B5-C35;
A10-B5-C41;
A11-B5-C1;
A11-B5-C7;
A11-B5-C13;
A11-B5-C19;
A11-B5-C25;
A3-B5-C22;
A3-B5-C28;
A3-B5-C34;
A3-B5-C40;
A3-B5-C46;
A4-B5-C6;
A4-B5-C12;
A4-B5-C18;
A4-B5-C24;
A4-B5-C30;
A4-B5-C36;
A4-B5-C42;
A5-B5-C2;
A5-B5-C8;
A5-B5-C14;
A5-B5-C20;
A5-B5-C26;
A5-B5-C32;
A5-B5-C38;
A5-B5-C44;
A6-B5-C4;
A6-B5-C10;
A6-B5-C16;
A6-B5-C22;
A6-B5-C28;
A6-B5-C34;
A6-B5-C40;
A6-B5-C46;
A7-B5-C6;
A7-B5-C12;
A7-B5-C18;
A7-B5-C24;
A7-B5-C30;
A7-B5-C36;
A7-B5-C42; A8-B5-C2; A8-B5-C8;
A8-B5-C14;
A8-B5-C20;
A8-B5-C26;
A8-B5-C32;
A8-B5-C38;
A8-B5-C44;
A9-B5-C4;
A9-B5-C10;
A9-B5-C16;
A9-B5-C22;
A9-B5-C28;
A9-B5-C34;
A9-B5-C40;
A9-B5-C46;
A10-B5-C6;
A10-B5-C12;
A10-B5-C18;
A10-B5-C24;
A10-B5-C30;
A10-B5-C36;
A10-B5-C42;
A11-B5-C2;
A11-B5-C8;
A11-B5-C14;
A11-B5-C20;
A11-B5-C26;
A3-B5-C23;
A3-B5-C29;
A3-B5-C35;
A3-B5-C41;
A4-B5-C1;
A4-B5-C7;
A4-B5-C13;
A4-B5-C19;
A4-B5-C25;
A4-B5-C31;
A4-B5-C37;
A4-B5-C43;
A5-B5-C3;
A5-B5-C9;
A5-B5-C15;
A5-B5-C21;
A5-B5-C27;
A5-B5-C33;
A5-B5-C39;
A5-B5-C45;
A6-B5-C5;
A6-B5-C11;
A6-B5-C17;
A6-B5-C23;
A6-B5-C29;
A6-B5-C35;
A6-B5-C41;
A7-B5-C1;
A7-B5-C7;
A7-B5-C13;
A7-B5-C19;
A7-B5-C25;
A7-B5-C31;
A7-B5-C37;
A7-B5-C43;
A8-B5-C3;
A8-B5-C9;
A8-B5-C15;
A8-B5-C21;
A8-B5-C27;
A8-B5-C33;
A8-B5-C39;
A8-B5-C45;
A9-B5-C5;
A9-B5-C11;
A9-B5-C17;
A9-B5-C23;
A9-B5-C29;
A9-B5-C35;
A9-B5-C41;
A10-B5-C1;
A10-B5-C7;
A10-B5-C13;
A10-B5-C19;
A10-B5-C25;
A10-B5-C31;
A10-B5-C37;
A10-B5-C43;
A11-B5-C3;
A11-B5-C9;
A11-B5-C15;
A11-B5-C21;
A11-B5-C27;
A3-B5-C24;
A3-B5-C30;
A3-B5-C36;
A3-B5-C42;
A4-B5-C2;
A4-B5-C8;
A4-B5-C14;
A4-B5-C20;
A4-B5-C26;
A4-B5-C32;
A4-B5-C38;
A4-B5-C44;
A5-B5-C4;
A5-B5-C10;
A5-B5-C16;
A5-B5-C22;
A5-B5-C28;
A5-B5-C34;
A5-B5-C40;
A5-B5-C46;
A6-B5-C6;
A6-B5-C12;
A6-B5-C18;
A6-B5-C24;
A6-B5-C30;
A6-B5-C36;
A6-B5-C42;
A7-B5-C2;
A7-B5-C8;
A7-B5-C14;
A7-B5-C20;
A7-B5-C26;
A7-B5-C32;
A7-B5-C38;
A7-B5-C44;
A8-B5-C4;
A8-B5-C10;
A8-B5-C16;
A8-B5-C22;
A8-B5-C28;
A8-B5-C34;
A8-B5-C40;
A8-B5-C46;
A9-B5-C6;
A9-B5-C12;
A9-B5-C18;
A9-B5-C24;
A9-B5-C30;
A9-B5-C36;
A9-B5-C42;
A10-B5-C2;
A10-B5-C8;
A1O-B5-C14;
A10-B5-C20;
A10-B5-C26;
A10-B5-C32;
A10-B5-C38;
A10-B5-C44;
A11-B5-C4;
A11-B5-C10;
A11-B5-C16;
A11-B5-C22;
A11-B5-C28;
A11-B5-C29;
A11-B5-C35;
A11-B5-C41;
A12-B5-C1;
A12-B5-C7;
A12-B5-C13;
A12-B5-C19;
A12-B5-C25;
A12-B5-C31;
A12-B5-C37;
A12-B5-C43;
A13-B5-C3;
A13-B5-C9;
A13-B5-C15;
A13-B5-C21;
A13-B5-C27;
A13-B5-C33;
A13-B5-C39;
A13-B5-C45; A14-B5-C5;
A14-B5-C11;
A14-B5-C17;
A14-B5-C23;
A14-B5-C29;
A14-B5-C35;
A14-B5-C41;
A15-B5-C1;
A15-B5-C7;
A15-B5-C13;
A15-B5-C19;
A15-B5-C25;
A15-B5-C31;
A15-B5-C37;
A15-B5-C43;
A16-B5-C3;
A16-B5-C9;
A16-B5-C15;
A16-B5-C21;
A16-B5-C27;
A16-B5-C33;
A16-B5-C39;
A16-B5-C45;
A17-B5-C5;
A17-B5-C11;
A17-B5-C17;
A17-B5-C23;
A17-B5-C29;
A17-B5-C35;
A17-B5-C41;
A18-B5-C1;
A18-B5-C7;
A18-B5-C13;
A18-B5-C19;
A18-B5-C25;
A18-B5-C31;
A18-B5-C37;
A18-B5-C43;
A19-B5-C3;
A19-B5-C9;
A19-B5-C15;
A19-B5-C21;
A19-B5-C27;
A19-B5-C33;
A11-B5-C30;
A11-B5-C36;
A11-B5-C42;
A12-B5-C2;
A12-B5-C8;
A12-B5-C14;
A12-B5-C20;
A12-B5-C26;
A12-B5-C32;
A12-B5-C38;
A12-B5-C44; A13-B5-C4;
A13-B5-C10;
A13-B5-C16;
A13-B5-C22;
A13-B5-C28;
A13-B5-C34;
A13-B5-C40;
A13-B5-C46; A14-B5-C6;
A14-B5-C12;
A14-B5-C18;
A14-B5-C24;
A14-B5-C3o;
A14-B5-C36;
A14-B5-C42;
A15-B5-C2;
A15-B5-C8;
A15-B5-C14;
A15-B5-C20;
A15-B5-C26;
A15-B5-C32;
A15-B5-C38;
A15-B5-C44;
A16-B5-C4;
A16-B5-C10;
A16-B5-C16;
A16-B5-C22;
A16-B5-C28;
A16-B5-C34;
A16-B5-C40;
A16-B5-C46;
A17-B5-C6;
A17-B5-C12;
A17-B5-C18;
A17-B5-C24;
A17-B5-C30;
A17-B5-C36;
A17-B5-C42;
A18-B5-C2;
A18-B5-C8;
A18-B5-C14;
A18-B5-C20;
A18-B5-C26;
A18-B5-C32;
A18-B5-C38;
A18-B5-C44; A19-B5-C4;
A19-B5-C10;
A19-B5-C16;
A19-B5-C22;
A19-B5-C28;
A19-B5-C34;
A11-B5-C31;
A11-B5-C37;
A11-B5-C43;
A12-B5-C3;
A12-B5-C9;
A12-B5-C15;
A12-B5-C21;
A12-B5-C27;
A12-B5-C33;
A12-B5-C39;
A12-B5-C45; A13-B5-C5;
A13-B5-C11;
A13-B5-C17;
A13-B5-C23;
A13-B5-C29;
A13-B5-C35;
A13-B5-C41;
A14-B5-C1;
A14-B5-C7;
A14-B5-C13;
A14-B5-C19;
A14-B5-C25;
A14-B5-C31;
A14-B5-C37;
A14-B5-C43;
A15-B5-C3;
A15-B5-C9;
A15-B5-C15;
A15-B5-C21;
A15-B5-C27;
A15-B5-C33;
A15-B5-C39;
A15-B5-C45;
A16-B5-C5;
A16-B5-C11;
A16-B5-C17;
A16-B5-C23;
A16-B5-C29;
A16-B5-C35;
A16-B5-C41;
A17-B5-C1;
A17-B5-C7;
A17-B5-C13;
A17-B5-C19;
A17-B5-C25;
A17-B5-C31;
A17-B5-C37;
A17-B5-C43;
A18-B5-C3;
A18-B5-C9;
A18-B5-C15;
A18-B5-C21;
A18-B5-C27;
A18-B5-C33;
A18-B5-C39;
A18-B5-C45;
A19-B5-C5;
A19-B5-C11;
A19-B5-C17;
A19-B5-C23;
A19-B5-C29;
A19-B5-C35;
A11-B5-C32;
A11-B5-C38;
A11-B5-C44; A12-B5-C4;
A12-B5-C10;
A12-B5-C16;
A12-B5-C22;
A12-B5-C28;
A12-B5-C34;
A12-B5-C40;
A12-B5-C46;
A13-B5-C6;
A13-B5-C12;
A13-B5-C18;
A13-B5-C24;
A13-B5-C30;
A13-B5-C36;
A13-B5-C42;
A14-B5-C2;
A14-B5-C8;
A14-B5-C14;
A14-B5-C20;
A14-B5-C26;
A14-B5-C32;
A14-B5-C38;
A14-B5-C44;
A15-B5-C4;
A15-B5-C10;
A15-B5-C16;
A15-B5-C22;
A15-B5-C28;
A15-B5-C34;
A15-B5-C40;
A15-B5-C46;
A16-B5-C6;
A16-B5-C12;
A16-B5-C18;
A16-B5-C24;
A16-B5-C30;
A16-B5-C36;
A16-B5-C42;
A17-B5-C2;
A17-B5-C8;
A17-B5-C14;
A17-B5-C20;
A17-B5-C26;
A17-B5-C32;
A17-B5-C38;
A17-B5-C44;
A18-B5-C4;
A18-B5-C10;
A18-B5-C16;
A18-B5-C22;
A18-B5-C28;
A18-B5-C34;
A18-B5-C40;
A18-B5-C46;
A19-B5-C6;
A19-B5-C12;
A19-B5-C18;
A19-B5-C24;
A19-B5-C30;
A19-B5-C36;
A11-B5-C33;
A11-B5-C39;
A11-B5-C45; A12-B5-C5;
A12-B5-C11;
A12-B5-C17;
A12-B5-C23;
A12-B5-C29;
A12-B5-C35;
A12-B5-C41;
A13-B5-C1;
A13-B5-C7;
A13-B5-C13;
A13-B5-C19;
A13-B5-C25;
A13-B5-C31;
A13-B5-C37;
A13-B5-C43;
A14-B5-C3;
A14-B5-C9;
A14-B5-C15;
A14-B5-C21;
A14-B5-C27;
A14-B5-C33;
A14-B5-C39;
A14-B5-C45;
A15-B5-C5;
A15-B5-C11;
A15-B5-C17;
A15-B5-C23;
A15-B5-C29;
A15-B5-C35;
A15-B5-C41;
A16-B5-C1;
A16-B5-C7;
A16-B5-C13;
A16-B5-C19;
A16-B5-C25;
A16-B5-C31;
A16-B5-C37;
A16-B5-C43;
A17-B5-C3;
A17-B5-C9;
A17-B5-C15;
A17-B5-C21;
A17-B5-C27;
A17-B5-C33;
A17-B5-C39;
A17-B5-C45;
A18-B5-C5;
A18-B5-C11;
A18-B5-C17;
A18-B5-C23;
A18-B5-C29;
A18-B5-C35;
A18-B5-C41;
A19-B5-C1;
A19-B5-C7;
A19-B5-C13;
A19-B5-C19;
A19-B5-C25;
A19-B5-C31;
A19-B5-C37;
A11-B5-C34;
A11-B5-C40;
A11-B5-C46; A12-B5-C6;
A12-B5-C12;
A12-B5-C18;
A12-B5-C24;
A12-B5-C30;
A12-B5-C36;
A12-B5-C42;
A13-B5-C2;
A13-B5-C8;
A13-B5-C14;
A13-B5-C20;
A13-B5-C26;
A13-B5-C32;
A13-B5-C38;
A13-B5-C44; A14-B5-C4;
A14-B5-C10;
A14-B5-C16;
A14-B5-C22;
A14-B5-C28;
A14-B5-C34;
A14-B5-C40;
A14-B5-C46;
A15-B5-C6;
A15-B5-C12;
A15-B5-C18;
A15-B5-C24;
A15-B5-C30;
A15-B5-C36;
A15-B5-C42;
A16-B5-C2;
A16-B5-C8;
A16-B5-C14;
A16-B5-C20;
A16-E5-C26;
A16-B5-C32;
A16-B5-C38;
A16-35-C44; A17-B5-C4;
A17-B5-C10;
A17-B5-C16;
A17-B5-C22;
A17-B5-C28;
A17-B5-C34;
A17-B5-C40;
A17-B5-C46; A18-B5-C6;
A18-B5-C12;
A18-B5-C18;
A18-B5-C24;
A18-B5-C30;
A18-B5-C36;
A18-B5-C42;
A19-B5-C2;
A19-B5-C8;
A19-B5-C14;
A19-B5-C20;
A19-B5-C26;
A19-B5-C32;
A19-B5-C38;
A19-B5-C39;
A19-B5-C45;
A20-B5-C5;
A20-B5-C11;
A20-B5-C17;
A20-B5-C23;
A20-B5-C29;
A20-B5-C35;
A20-B5-C41;
A21-B5-C1;
A21-B5-C7;
A21-B5-C13;
A21-B5-C19;
A21-B5-C25;
A21-B5-C31;
A21-B5-C37;
A21-B5-C43;
A22-B5-C3;
A22-B5-C9;
A22-B5-C15;
A22-B5-C21;
A22-B5-C27;
A22-B5-C33;
A22-B5-C39;
A22-B5-C45;
A23-B5-C5;
A23-B5-C11;
A23-B5-C17;
A23-B5-C23;
A23-B5-C29;
A23-B5-C35;
A23-B5-C41;
A24-B5-C1;
A24-B5-C7;
A24-B5-C13;
A24-B5-C19;
A24-B5-C25;
A24-B5-C31;
A24-B5-C37;
A24-B5-C43;
A25-B5-C3;
A25-B5-C9;
A25-B5-C15;
A25-B5-C21;
A25-B5-C27;
A25-B5-C33;
A25-B5-C39;
A25-B5-C45;
A26-B5-C5;
A26-B5-C11;
A26-B5-C17;
A26-B5-C23;
A26-B5-C29;
A26-B5-C35;
A26-B5-C41;
A27-B5-C1;
A27-B5-C7;
A27 B5-C13;
A27-B5-C19;
A27-B5-C25;
A27-B5-C31;
A27-B5-C37;
A27-B5-C43;
A19-B5-C40;
A19-B5-C46;
A20-B5-C6;
A20-B5-C12;
A20-B5-C18;
A20-B5-C24;
A20-B5-C30;
A20-B5-C36;
A20-B5-C42;
A21-B5-C2;
A21-B5-C8;
A21-B5-C14;
A21-B5-C20;
A21-B5-C26;
A21-B5-C32;
A21-B5-C38;
A21-B5-C44;
A22-B5-C4;
A22-B5-C10;
A22-B5-C16;
A22-B5-C22;
A22-B5-C28;
A22-B5-C34;
A22-B5-C40;
A22-B5-C46;
A23-B5-C6;
A23-B5-C12;
A23-B5-C18;
A23-B5-C24;
A23-B5-C30;
A23-B5-C36;
A23-B5-C42;
A24-B5-C2;
A24-B5-C8;
A24-B5-C14;
A2'4-B5-C20;
A24-B5-C26;
A24-B5-C32;
A24-B5-C38;
A24-B5-C44;
A25-B5-C4;
A25-B5-C10;
A25-B5-C16;
A25-B5-C22;
A25-B5-C28;
A25-B5-C34;
A25-B5-C40;
A25-B5-C46;
A26-B5-C6;
A26-B5-C12;
A26-B5-C18;
A26-B5-C24;
A26-B5-C30;
A26-B5-C36;
A26-B5-C42;
A27-B5-C2;
A27-B5-C8;
A27-B5-C14;
A27-B5-C20;
A27-B5-C26;
A27-B5-C32;
A27-B5-C38;
A27-B5-C44;
A19-B5-C41;
A20-B5-C1;
A20-B5-C7;
A20-B5-C13;
A20-B5-C19;
A20-B5-C25;
A20-B5-C31;
A20-B5-C37;
A20-B5-C43;
A21-B5-C3;
A21-B5-C9;
A21-B5-C15;
A21-B5-C21;
A21-B5-C27;
A21-B5-C33;
A21-B5-C39;
A21-B5-C45;
A22-B5-C5;
A22-B5-C11;
A22-B5-C17;
A22-B5-C23;
A22-B5-C29;
A22-B5-C35;
A22-B5-C41;
A23-B5-C1;
A23-B5-C7;
A23-B5-C13;
A23-B5-C19;
A23-B5-C25;
A23-B5-C31;
A23-B5-C37;
A23-B5-C43;
A24-B5-C3;
A24-B5-C9;
A24-B5-C15;
A24-B5-C21;
A24-B5-C27;
A24-B5-C33;
A24-B5-C39;
A24-B5-C45;
A25-B5-C5;
A25-B5-C11;
A25-B5-C17;
A25-B5-C23;
A25-B5-C29;
A25-B5-C35;
A25-B5-C41;
A26-B5-C1;
A26-B5-C7;
A26-B5-C13;
A26-B5-C19;
A26-B5-C25;
A26-B5-C31;
A26-B5-C37;
A26-B5-C43;
A27-B5-C3;
A27-B5-C9;
A27-B5-C15;
A27-B5-C21;
A27-B5-C27;
A27-B5-C33;
A27-B5-C39;
A27-B5-C45;
A19-B5-C42;
A20-B5-C2;
A20-B5-C8;
A20-B5-C14;
A20-B5-C20;
A20-B5-C26;
A20-B5-C32;
A20-B5-C38;
A20-B5-C44; A21-B5-C4;
A21-B5-C10;
A21-B5-C16;
A21-B5-C22;
A21-B5-C28;
A21-B5-C34;
A21-B5-C40;
A21-B5-C46;
A22-B5-C6;
A22-B5-C12;
A22-B5-C18;
A22-B5-C24;
A22-B5-C30;
A22-B5-C36;
A22-B5-C42;
A23-B5-C2;
A23-B5-C8;
A23-B5-C14;
A23-B5-C20;
A23-B5-C26;
A23-B5-C32;
A23-B5-C38;
A23-B5-C44;
A24-B5-C4;
A24-B5-C10;
A24-B5-C16;
A24-B5-C22;
A24-B5-C28;
A24-B5-C34;
A24-B5-C40;
A24-B5-C46;
A25-B5-C6;
A25-B5-C12;
A25-B5-C18;
A25-B5-C24;
A25-B5-C30;
A25-B5-C36;
A25-B5-C42;
A26-B5-C2;
A26-B5-C8;
A26-B5-C14;
A26-B5-C20;
A26-B5-C26;
A26-B5-C32;
A26-B5-C38;
A26-B5-C44;
A27-B5-C4;
A27-B5-C10;
A27-B5-C16;
A27-B5-C22;
A27-B5-C28;
A27-B5-C34;
A27-B5-C40;
A27-B5-C46;
A19-B5-C43;
A20-B5-C3;
A20-B5-C9;
A20-B5-C15;
A20-B5-C21;
A20-B5-C27;
A20-B5-C33;
A20-B5-C39;
A20-B5-C45;
A21-B5-C5;
A21-B5-C11;
A21-B5-C17;
A21-B5-C23;
A21-B5-C29;
A21-B5-C35;
A21-B5-C41;
A22-B5-C1;
A22-B5-C7;
A22-B5-C13;
A22-B5-C19;
A22-B5-C25;
A22-B5-C31;
A22-B5-C37;
A22-B5-C43;
A23-B5-C3;
A23-B5-C9;
A23-B5-C15;
A23-B5-C21;
A23-B5-C27;
A23-B5-C33;
A23-B5-C39;
A23-B5-C45;
A24-B5-C5;
A24-B5-C11;
A24-B5-C17;
A24-B5-C23;
A24-B5-C29;
A24-B5-C35;
A24-B5-C41;
A25-B5-C1;
A25-B5-C7;
A25-B5-C13;
A25-B5-C19;
A25-B5-C25;
A25-B5-C31;
A25-B5-C37;
A25-B5-C43;
A26-B5-C3;
A26-B5-C9;
A26-B5-C15;
A26-B5-C21;
A26-B5-C27;
A26-B5-C33;
A26-B5-C39;
A26-B5-C45; A27-B5-C5;
A27-B5-C11;
A27-B5-C17;
A27-B5-C23;
A27-B5-C29;
A27-B5-C35;
A27-B5-C41;
A28-B5-C1;
A19-B5-C44;
A20-B5-C4;
A20-B5-C10;
A20-B5-C16;
A20-B5-C22;
A20-B5-C28;
A20-B5-C34;
A20-B5-C40;
A20-B5-C46; A21-B5-C6;
A21-B5-C12;
A21-B5-C18;
A21-B5-C24;
A21-B5-C30;
A21-B5-C36;
A21-B5-C42;
A22-B5-C2;
A22-B5-C8;
A22-B5-C14;
A22-B5-C20;
A22-B5-C26;
A22-B5-C32;
A22-B5-C38;
A22-B5-C44; A23-B5-C4;
A23-B5-C10;
A23-B5-C16;
A23-B5-C22;
A23-B5-C28;
A23-B5-C34;
A23-B5-C40;
A23-B5-C46; A24-B5-C6;
A24-B5-C12;
A24-B5-C18;
A24-B5-C24;
A24-B5-C30;
A24-B5-C36;
A24-B5-C42;
A25-B5-C2;
A25-B5-C8;
A25-B5-C14;
A25-B5-C20;
A25-B5-C26;
A25-B5-C32;
A25-B5-C38;
A25-B5-C44; A26-B5-C4;
A26-B5-C10;
A26-B5-C16;
A26-B5-C22;
A26-B5-C28;
A26-B5-C34;
A26-B5-C40;
A26-B5-C46; A27-B5-C6;
A27-B5-C12;
A27-B5-C18;
A27-B5-C24;
A27-B5-C30;
A27-B5-C36;
A27-B5-C42;
A28-B5-C2;
A28-B5-C3;
A28-B5-C9;
A28-B5-C15;
A28-B5-C21;
A28-B5-C27;
A28-B5-C33;
A28-B5-C39;
A28-B5-C45;
A1-B6-C5;
A1-B6-C11;
A1-B6-C17;
A1-B6-C23;
A1-B6-C29;
A1-B6-C35;
A1-B6-C41;
A2-B6-C1;
A2-B6-C7;
A2-B6-C13;
A2-B6-C19;
A2-B6-C25;
A2-B6-C31;
A2-B6-C37;
A2-B6-C43;
A3-B6-C3;
A3-B6-C9;
A3-B6-C15;
A3-B6-C21;
A3-B6-C27;
A3-B6-C33;
A3-B6-C39;
A3-B6-C45;
A4-B6-C5;
A4-B6-C11;
A4-B6-C17;
A4-B6-C23;
A4-B6-C29;
A4-B6-C35;
A4-B6-C41;
A5-B6-C1;
A5-B6-C7;
A5-B6-C13;
A5-B6-C19;
A5-B6-C25;
A5-B6-C31;
A5-B6-C37;
A5-B6-C43;
A6-B6-C3;
A6-B6-C9;
A6-B6-C15;
A6-B6-C21;
A6-B6-C27;
A6-B6-C33;
A6-B6-C39;
A6-B6-C45;
A7-B6-C5;
A7-B6-C11;
A7-B6-C17;
A7-B6-C23;
A7-B6-C29;
A7-B6-C35;
A7-B6-C41;
A8-B6-C1;
A8-B6-C7;
A28-B5-C4;
A28-B5-C10;
A28-B5-C16;
A28-B5-C22;
A28-B5-C28; A28-B5-C34; A28-B5-C40; A28-B5-C46;
A1-B6-C6;
A1-B6-C12;
A1-B6-C18;
A1-B6-C24;
A1-B6-C30;
A1-B6-C36;
A1-B6-C42;
A2-B6-C2;
A2-B6-C8;
A2-B6-C14;
A2-B6-C20;
A2-B6-C26;
A2-B6-C32;
A2-B6-C38;
A2-B6-C44;
A3-B6-C4;
A3-B6-C10;
A3-B6-C16;
A3-B6-C22;
A3-B6-C28;
A3-B6-C34;
A3-B6-C40;
A3-B6-C46;
A4-B6-C6;
A4-B6-C12;
A4-B6-C18;
A4-B6-C24;
A4-B6-C30;
A4-B6-C36;
A4-B6-C42;
A5-B6-C2;
A5-B6-C8;
A5-B6-C14;
A5-B6-C20;
A5-B6-C26;
A5-B6-C32;
A5-B6-C38;
A5-B6-C44;
A6-B6-C4;
A6-B6-C10;
A6-B6-C16;
A6-B6-C22;
A6-B6-C28;
A6-B6-C34;
A6-B6-C40;
A6-B6-C46;
A7-B6-C6;
A7-B6-C12;
A7-B6-C18;
A7-B6-C24;
A7-B6-C30;
A7-B6-C36;
A7-B6-C42;
A8-B6-C2;
A8-B6-C8;
A28-B5-C5;
A28-B5-C11;
A28-B5-C17;
A28-B5-C23;
A28-B5-C29;
A28-B5-C35;
A28-B5-C41;
A1-B6-C1;
A1-B6-C7;
A1-B6-C13;
A1-B6-C19;
A1-B6-C25;
A1-B6-C31;
A1-B6-C37;
A1-B6-C43;
A2-B6-C3;
A2-B6-C9;
A2-B6-C15;
A2-B6-C21;
A2-B6-C27;
A2-B6-C33;
A2-B6-C39;
A2-B6-C45;
A3-B6-C5;
A3-B6-C11;
A3-B6-C17;
A3-B6-C23;
A3-B6-C29;
A3-B6-C35;
A3-B6-C41;
A4-B6-C1;
A4-B6-C7;
A4-B6-C13;
A4-B6-C19;
A4-B6-C25;
A4-B6-C31;
A4-B6-C37;
A4-B6-C43;
A5-B6-C3;
A5-B6-C9;
A5-B6-C15;
A5-B6-C21;
A5-B6-C27;
A5-B6-C33;
A5-B6-C39;
A5-B6-C45;
A6-B6-C5;
A6-B6-C11;
A6-B6-C17;
A6-B6-C23;
A6-B6-C29;
A6-B6-C35;
A6-B6-C41;
A7-B6-C1;
A7-B6-C7;
A7-B6-C13;
A7-B6-C19;
A7-B6-C25;
A7-B6-C31;
A7-B6-C37;
A7-B6-C43;
A8-B6-C3;
A8-B6-C9;
A28-B5-C6;
A28-B5-C12;
A28-B5-C18;
A28-B5-C24;
A28-B5-C30;
A28-B5-C36;
A28-B5-C42;
A1-B6-C2;
A1-B6-C8;
A1-B6-C14;
A1-B6-C20;
A1-B6-C26;
A1-B6-C32;
A1-B6-C38;
A1-B6-C44;
A2-B6-C4;
A2-B6-C10;
A2-B6-C16;
A2-B6-C22;
A2-B6-C28; A2-B6-C34; A2-B6-C40; A2-B6-C46;
A3-B6-C6;
A3-B6-C12;
A3-B6-C18;
A3-B6-C24;
A3-B6-C30;
A3-B6-C36;
A3-B6-C42;
A4-B6-C2;
A4-B6-C8;
A4-B6-C14;
A4-B6-C20;
A4-B6-C26;
A4-B6-C32;
A4-B6-C38;
A4-B6-C44;
A5-B6-C4;
A5-B6-C10;
A5-B6-C16;
A5-B6-C22;
A5-B6-C28;
A5-B6-C34;
A5-B6-C40;
A5-B6-C46;
A6-B6-C6;
A6-B6-C12;
A6-B6-C18;
A6-B6-C24;
A6-B6-C30;
A6-B6-C36;
A6-B6-C42;
A7-B6-C2;
A7-B6-C8;
A7-B6-C14;
A7-B6-C20;
A7-B6-C26;
A7-B6-C32;
A7-B6-C38;
A7-B6-C44;
A8-B6-C4;
A8-B6-C10;
A28-B5-C7;
A28-B5-C13;
A28-B5-C19;
A28-B5-C25;
A28-B5-C31;
A28-B5-C37;
A28-B5-C43;
A1-B6-C3;
A1-B6-C9;
A1-B6-C15;
A1-B6-C21;
A1-B6-C27;
A1-B6-C33;
A1-E6-C39;
A1-B6-C45;
A2-B6-C5;
A2-B6-C11;
A2-B6-C17;
A2-B6-C23;
A2-B6-C29;
A2-B6-C35;
A2-B6-C41;
A3-B6-C1;
A3-B6-C7;
A3-B6-C13;
A3-B6-C19;
A3-B6-C25;
A3-B6-C31;
A3-B6-C37;
A3-B6-C43;
A4-B6-C3;
A4-B6-C9;
A4-B6-C15;
A4-B6-C21;
A4-B6-C27;
A4-B6-C33;
A4-B6-C39;
A4-B6-C45;
A5-B6-C5;
A5-B6-C11;
A5-B6-C17;
A5-B6-C23;
A5-B6-C29;
A5-B6-C35;
A5-B6-C41;
A6-B6-C1;
A6-B6-C7;
A6-B6-C13;
A6-B6-C19;
A6-B6-C25;
A6-B6-C31;
A6-B6-C37;
A6-B6-C43;
A7-B6-C3;
A7-B6-C9;
A7-B6-C15;
A7-B6-C21;
A7-B6-C27;
A7-B6-C33;
A7-B6-C39;
A7-B6-C45;
A8-B6-C5;
A8-B6-C11;
A28-B5-C8;
A28-B5-C14;
A28-B5-C20;
A28-B5-C26;
A28-B5-C32;
A28-B5-C38;
A28-B5-C44;
A1-B6-C4;
A1-B6-C10;
A1-B6-C16;
A1-B6-C22;
A1-B6-C28;
A1-B6-C34;
A1-B6-C40;
A1-B6-C46;
A2-B6-C6;
A2-B6-C12;
A2-B6-C18;
A2-B6-C24;
A2-B6-C30;
A2-B6-C36;
A2-B6-C42;
A3-B6-C2;
A3-B6-C8;
A3-B6-C14;
A3-B6-C20;
A3-B6-C26;
A3-B6-C32;
A3-B6-C38;
A3-B6-C4;
A4-B6-C4;
A4-B6-C10;
A4-B6-C16;
A4-B6-C22;
A4-B6-C28;
A4-B6-C34;
A4-B6-C40;
A4-B6-C46;
A5-B6-C6;
A5-B6-C12;
A5-B6-C18;
A5-B6-C24;
A5-B6-C30;
A5-B6-C36;
A5-B6-C42;
A6-B6-C2;
A6-B6-C8;
A6-B6-C14;
A6-B6-C20;
A6-B6-C26;
A6-B6-C32;
A6-B6-C38;
A6-B6-C44;
A7-B6-C4;
A7-B6-C10;
A7-B6-C16;
A7-B6-C22;
A7-B6-C28;
A7-B6-C34;
A7-B6-C40;
A7-B6-C46;
A8-B6-C6;
A8-B6-C12;
A8-B6-C13; '
A8-B6-C19;
A8-B6-C25;
A8-B6-C31;
A8-B6-C37;
A8-B6-C43;
A9-B6-C3;
A9-B6-C9;
A9-B6-C15;
A9-B6-C21;
A9-B6-C27;
A9-B6-C33;
A9-B6-C39;
A9-B6-C45;
A10-B6-C5;
A10-B6-C11;
A1.0-B6-C17;
A10-B6-C23;
A10-B6-C29;
A10-B6-C35;
A10-B6-C41;
A11-B6-C1;
A11-B6-C7;
A11-B6-C13;
A11-B6-C19;
A11-B6-C25;
A11-B6-C31;
A11-B6-C37;
A11-B6-C43;
A12-B6-C3;
A12-B6-C9;
A12-B6-C15;
A12-B6-C21;
A12-B6-C27;
A12-B6-C33;
A12-B6-C39;
A12-B6-C45;
A13-B6-C5;
A13-B6-C11;
A13-B6-C17;
A13-B6-C23;
A13-B6-C29;
A13-B6-C35;
A13-B6-C41;
A14-B6-C1;
A14-B6-C7;
A14-B6-C13;
A14-B6-C19;
A14-B6-C25;
A14-B6-C31;
A14-B6-C37;
A14-B6-C43;
A15-B6-C3;
A15-B6-C9;
A15-B6-C15;
A15-B6-C21;
A15-B6-C27;
A15-B6-C33;
A15-B6-C39;
A15-B6-C45;
A16-B6-C5;
A16-B6-C11;
A16-B6-C17;
A8-B6-C14;
A8-B6-C20;
A8-B6-C26;
A8-B6-C32;
A8-B6-C38;
A8-B6-C44;
A9-B6-C4;
A9-B6-C10;
A9-B6-C16;
A9-B6-C22;
A9-B6-C28;
A9-B6-C34;
A9-B6-C40;
A9-B6-C46;
A10-B6-C6;
A10-B6-C12;
A10-B6-C18;
A10-B6-C24;
A10-B6-C30;
A10-B6-C36;
A10-B6-C42;
AU-B6-C2;
A11-B6-C8;
AL1-B6-C14; A11-B6-C20;
A11-B6-C26;
A11-B6-C32;
A11-B6-C38;
A11-B6-C44;
A12-B6-C4;
A12-B6-C10;
A12-B6-C16;
A12-B6-C22;
A12-B6-C28;
A12-B6-C34;
A12-B6-C40;
A12-B6-C46;
A13-B6-C6;
A13-B6-C12;
A13-B6-C18;
A13-B6-C24;
A13-B6-C30;
A13-B6-C36;
A13-B6-C42;
A14-B6-C2;
A14-B6-C8;
A14-B6-C14;
A14-B6-C20;
A14-B6-C26;
A14-B6-C32;
A14-B6-C38;
A14-B6-C44;
A15-B6-C4;
A15-B6-C10;
A15-B6-C16;
A15-B6-C22;
A15-B6-C28;
A15-B6-C34;
A15-B6-C40;
A15-B6-C46;
A16-B6-C6;
A16-B6-C12;
A16-B6-C18;
A8-B6-C15;
A8-B6-C21;
A8-B6-C27;
A8-B6-C33;
A8-B6-C39;
A8-B6-C45;
A9-B6-C5;
A9-B6-C11;
A9-B6-C17;
A9-B6-C23;
A9-B6-C29;
A9-B6-C35;
A9-B6-C41;
A10-B6-C1;
A10-B6-C7;
A10-B6-C13;
A10-B6-C19;
A10-B6-C25;
A10-B6-C31;
A10-B6-C37;
A10-B6-C43;
A11-B6-C3;
A11-B6-C9;
A11-B6-C15;
A11-B6-C21;
A11-B6-C27;
A11-B6-C33;
A11-B6-C39;
A11-B6-C45;
A12-B6-C5;
A12-B6-C11;
A12-B6-C17;
A12-B6-C23;
A12-B6-C29;
A12-B6-C35;
A12-B6-C41;
A13-B6-C1;
A13-B6-C7;
A13-B6-C13;
A13-B6-C19;
A13-B6-C25;
A13-B6-C31;
A13-B6-C37;
A13-B6-C43;
A14-B6-C3;
A14-B6-C9;
A14-B6-C15;
A14-B6-C21;
A14-B6-C27;
A14-B6-C33;
A14-B6-C39;
A14-B6-C45;
A15-B6-C5;
A15-36-C11;
A15-E6-C17;
A15-E6-C23;
A15-E6-C29;
A15-B6-C35;
A15-B6-C41;
A16-B6-C1;
A16-B6-C7;
A16-B6-C13;
A16-B6-C19;
A8-B6-C16;
A8-B6-C22;
A8-B6-C28;
A8-B6-C34;
A8-B6-C40;
A8-B6-C46;
A9-B6-C6;
A9-B6-C12;
A9-B6-C18;
A9-B6-C24;
A9-B6-C30;
A9-B6-C36;
A9-B6-C42;
A10-B6-C2;
A10-B6-C8;
A10-B6-C14;
A10-B6-C20;
A10-B6-C26;
A10-B6-C32;
A10-B6-C38;
A10-B6-C44;
A11-B6-C4;
A11-B6-C10;
A11-B6-C16;
A11-B6-C22;
A11-B6-C28;
A11-B6-C34;
A11-B6-C40;
A11-B6-C46;
A12-B6-C6;
A12-B6-C12;
A12-B6-C18;
A12-B6-C24;
A12-B6-C30;
A12-B6-C36;
A12-B6-C42;
A13-B6-C2;
A13-B6-C8;
A13-B6-C14;
A13-B6-C20;
A13-B6-C26;
A13-B6-C32;
A13-B6-C38;
A13-B6-C44;
A14-B6-C4;
Α14-B6-C10;
A14-B6-C16;
A14-B6-C22;
A14-B6-C28;
A14-B6-C34;
A14-B6-C40;
A14-B6-C46;
A15-B6-C6;
A15-B6-C12;
A15-B6-C18;
A15-B6-C24;
A15-B6-C30;
A15-B6-C36;
A15-B6-C42;
A16-B6-C2;
A16-B6-C8;
A16-B6-C14;
A16-B6-C20;
A8-B6-C17;
A8-B6-C23;
A8-B6-C29;
A8-B6-C35;
A8-B6-C41;
A9-B6-C1;
A9-B6-C7;
A9-B6-C13;
A9-B6-C19;
A9-B6-C25;
A9-B6-C31;
A9-B6-C37;
A9-B6-C43;
A10-B6-C3;
A10-B6-C9;
A10-B6-C15;
A10-B6-C21;
A10-B6-C27;
A10-B6-C33;
A10-B6-C39;
A10-B6-C45;
A11-B6-C5;
A11-B6-C11;
A11-B6-C17;
A11-B6-C23;
A11-B6-C29;
A11-B6-C35;
A11-B6-C41;
A12-B6-C1;
A12-B6-C7;
A12-B6-C13;
A12-B6-C19;
A12-B6-C25;
A12-E6-C31;
A12-B6-C37;
A12-B6-C43;
A13-B6-C3;
A13-B6-C9;
A13-B6-C15;
A13-B6-C21;
A13-B6-C27;
A13-B6-C33;
A13-B6-C39;
A13-B6-C45; A14-B6-C5;
A14-B6-C11;
A14-B6-C17;
A14-B6-C23;
A14-B6-C29;
A14-B6-C35;
A14-B6-C41;
A15-B6-C1;
A15-B6-C7;
A15-BS-C13;
A15-B6-C19;
A15 B6-C25;
A15-B6-C31;
A15-B6-C37;
A15-B6-C43;
A16-B6-C3;
A16-B6-C9;
A16-B6-C15;
A16-B6-C21;
A8-B6-C18;
A8-B6-C24;
A8-B6-C30;
A8-B6-C36;
A8-B6-C42;
A9-B6-C2;
A9-B6-C8;
A9-B6-C14;
A9-B6-C20;
A9-B6-C26;
A9-B6-C32;
A9-B6-C38;
A9-B6-C44;
A10-B6-C4;
A10-B6-C10;
A10-B6-C16;
A10-26-C22;
A10-B6-C28;
A10-B6-C34;
A10-B6-C40;
A10-B6-C46;
A11-B6-C6;
A11-B6-C12;
A11-B6-C18;
A11-B6-C24;
A11-B6-C30;
A11-B6-C36;
A11-B6-C42;
A12-B6-C2;
A12-B6-C8;
A12-B6-C14;
A12-B6-C20;
A12-B6-C26;
A12-B6-C32;
A12-56-C3S;
A12-B6-C44;
A13-E6-C 4;
A13-BC-C10;
A13-E6-C16;
A13-B6-C22;
A13-B6-C28;
A13-B6-C34;
A13-B6-C4O;
A13-B6-C46;
A14-E6-C 6;
A14-E6-C 12;
A14-B6-C18;
A14-B6-C24;
A14-B6-C30;
A14-B6-C36;
A14-B6-C42;
A15-B6-C2;
A15-B6-C8;
A15-B6-C14;
A15-B6-C20;
A15-B6-C26;
A15-B6-C32;
A15-B6-C38;
A15-B6-C44;
A16-B6-C4;
A16-B6-C10;
A16-B6-C16;
A16-B6-C22;
A16-B6-C23;
A16-B6-C29;
A16-B6-C35;
A16-B6-C41;
A17-B6-C1;
A17-B6-C7;
A17-B6-C13;
A17-B6-C19;
A17-B6-C25;
A17-B6-C31;
A17-B6-C37;
A17-B6-C43;
A18-B6-C3;
A18-B6-C9;
A18-B6-C15;
A18-B6-C21;
A18-B6-C27;
A18-B6-C33;
A18-B6-C39;
A18-B6-C45;
A19-B6-C5;
A19-B6-C11;
A19-B6-C17;
A19-B6-C23;
A19-B6-C29;
A19-B6-C35;
A19-B6-C41;
A20-B6-C1;
A20-B6-C7;
A20-B6-C13;
A20-B6-C19;
A20-B6-C25;
A20-B6-C31;
A20-B6-C37;
A20-B6-C43;
A21-B6-C3;
A21-B6-C9;
A21-B6-C15;
A21-B6-C21;
A21-B6-C27;
A21-B6-C33;
A21-B6-C39;
A21-B6-C45;
A22-B6-C5;
A22-B6-C11;
A22-B6-C17;
A22-B6-C23;
A22-B6-C29;
A22-B6-C35;
A22-B6-C41;
A23-B6-C1;
A23-B6-C7;
A23-B6-C13;
A23-B6-C19;
A23-B6-C25;
A23-B6-C31; A23-B6-C37;
A23-B6-C43;
A24-B6-C3;
A24-B6-C9;
A24-B6-C15;
A24-B6-C21;
A24-B6-C27;
AI6-B6-C24;
A16-B6-C30;
A16-B6-C36;
A16-B6-C42;
A17-B6-C2;
A17-B6-C8;
A17-B6-C14;
A17-B6-C20;
A17-B6-C26;
A17-B6-C32;
A17-B6-C38;
A17-B6-C44; A18-B6-C4;
A18-B6-C10;
A18-B6-C16;
A18-B6-C22;
A18-B6-C28;
A18-B6-C34;
A18-B6-C40;
A18-B6-C46;
A19-B6-C6;
A19-B6-C12;
A19-B6-C18;
A19-B6-C24;
A19-B6-C30;
A19-B6-C36;
A19-B6-C42;
A20-B6-C2;
A20-B6-C8;
A20-B6-C14;
A20-B6-C20;
A20-B6-C26;
A20-B6-C32;
A20-B6-C38;
A20-B6-C44;
A21-B6-C4;
A21-B6-C10;
A21-B6-C16;
A21-B6-C22;
A21-B6-C28;
A21-B6-C34;
A21-B6-C40;
A21-B6-C46;
A22-B6-C6;
A22-B6-C12;
A22-B6-C18;
A22-B6-C24;
A22-B6-C30;
A22-B6-C36;
A22-B6-C42;
A23-B6-C2;
A23-B6-C8;
A23-B6-C14;
A23-B6-C20;
A23-B6-C26;
A23-B6-C32;
A23-B6-C38;
A23-B6-C44;
A24-B6-C4;
A24-B6-C10;
A24-B6-C16;
A24-B6-C22;
A24-B6-C28;
A16-B6-C25;
A16-B6-C31;
A16-B6-C37;
A16-B6-C43;
A17-B6-C3;
A17-B6-C9;
A17-B6-C15;
A17-B6-C21;
A17-B6-C27;
A17-B6-C33;
A17-B6-C39;
A17-B6-C45;
A18-B6-C5;
A18-B6-C11;
A18-B6-C17;
A18-B6-C23;
A18-B6-C29;
A18-B6-C35;
A18-B6-C41;
A19-B6-C1;
A19-B6-C7;
A19-B6-C13;
A19-B6-C19;
A19-B6-C25;
A19-B6-C31;
A19-B6-C37;
A19-B6-C43;
A20-B6-C3;
A20-B6-C9;
A20-B6-C15;
A20-B6-C21;
A20-B6-C27;
A20-B6-C33;
A20-B6-C39;
A20-B6-C45;
A21-B6-C5;
A21-B6-C11;
A21-B6-C17;
A21-B6-C23;
A21-B6-C29;
A21-B6-C35;
A21-B6-C41;
A22-B6-C1;
A22-B6-C7;
A22-B6-C13;
A22-B6-C19;
A22-B6-C25;
A22-36-C31;
A22-B6-C37;
A22-B6-C43;
A23-B6-C3;
A23-B6-C9;
A23-B6-C15;
A23-B6-C21;
A23-B6-C27;
A23-B6-C33;
A23-B6-C39;
A23-B6-C45;
A24-B6-C5;
A24-B6-C11;
A24-B6-C17;
A24-B6-C23;
A24-B6-C29;
A16-B6-C26;
A16-B6-C32;
A16-B6-C38;
A16-B6-C44;
A17-B6-C4;
A17-B6-C10;
A17-B6-C16;
A17-B6-C22;
A17-B6-C28;
A17-B6-C 3-4;
A17-B6-C40;
A17-B6-C46;
A18-B6-C6;
A18-B6-C12;
A18-B6-C18;
A18-B6-C24;
A18-B6-C30;
A18-B6-C36;
A18-B6-C42;
A19-B6-C2;
A19-B6-C8;
A19-B6-C14;
A19-B6-C20;
A19-36-C26;
A19-B6-C32;
A19-B6-C38;
A19-B6-C44; A20-B6-C4;
A20-B6-C10;
A20-B6-C16;
A20-B6-C22;
A20-B6-C28;
A20-B6-C34;
A20-B6-C40;
A20-B6-C46;
A21-B6-C6;
A21-B6-C12;
A21-B6-C18;
A21-B6-C24;
A21-B6-C30;
A21-B6-C36;
A21-B6-C42;
A22-B6-C2;
A22-B6-C8;
A22-B6-C14;
A22-B6-C20;
A22-B6-C26;
A22-B6-C32;
A22-B6-C38;
A22-B6-C44;
A23-B6-C4;
A23-B6-C10;
A23-B6-C16;
A23-B6-C22;
A23-B6-C28;
A23-B6-C34;
A23-B6-C40;
A23-B6-C46;
A24-B6-C6;
A24-B6-C12;
A24-B6-C18;
A24-B6-C24;
A24-B6-C30;
A16-B6-C27;
A16-B6-C33;
A16-B6-C39;
A16-B6-C45;
A17-B6-C5;
A17-B6-C11;
A17-B6-C17;
A17-B6-C23;
A17-B6-C29;
A17-B6-C35;
A17-B6-C41;
A18-B6-C1;
A18-B6-C7;
A18-B6-C13;
A18-B6-C19;
A18-B6-C25;
A18-B6-C31;
A18-B6-C37;
A18-B6-C43;
A19-B6-C3;
A19-B6-C9;
A19-B6-C15;
A19-B6-C21;
A19-B6-C27;
A19-B6-C33;
A19-B6-C39;
A19-B6-C45;
A20-B6-C5;
A20 B6-C11;
A20-B6-C17;
A20-B6-C23;
A20-B6-C29;
A20-B6-C35;
A20-B6-C41;
A21-B6-C1;
A21-B6-C7;
A21-B6-C13;
A21-B6-C19;
A21-B6-C25;
A21 B6-C31;
A21-B6-C37;
A21-B6-C43;
A22-B6-C3;
A22-B6-C9;
A22-B6-C15;
A22-B6-C21;
A22-B6-C27;
A22-B6-C33;
A22-B6-C39;
A22-B6-C45;
A23-B6-C5;
A23-B6-C11;
A23-B6-C17;
A23-B6-C23;
A23-B6-C29;
A23-B6-C35;
A23-B6-C41;
A24-B6-C1;
A24-B6-C7;
A24-B6-C13;
A24-B6-C19;
A24-B6-C25;
A24-B6-C31;
A16-B6-C28;
A16-B6-C34;
A16-B6-C40;
A16-B6-C46; A17-B6-C6;
A17-B6-C12;
A17-B6-C18;
A17-B6-C24;
A17-B6-C30;
A17-BO-C36;
A17-B6-C42;
A18-B6-C2;
A18-B6-C8;
A18-BC-C14;
A18-B5-C20;
A18-B6-C26;
A18-B6-C32;
A18-B6-C38;
Α18-Εc-C44;
A19-Eo-C4;
A19-E6-C10;
A19-E6-C16;
A19-BC-C22;
A19-EC-C28;
A19-B5-C34;
A19-B5-C40;
A19-BC-C46; A20-B6-C6;
A20-BI-C12;
A20-EC-C 18;
A20-B6-C24;
A20-BC-C30;
A20-B6-C36;
A20-B6-C42;
A21-B6-C2;
A21-B6-C8;
A21-B6-C14;
A21-B6-C20;
A21-B6-C26;
A21-E6-C32;
A21-B6-C38;
A21-B6-C44;
A22-E6-C 4;
A22-EC-C10;
A22-EC-C16;
A22-E6-C22;
A22-E6-C28;
A22-E6-C34;
A22-BC-C40;
A22-B6-C46; A23-BC-C6;
A23-B6-C12;
A23-B6-C18;
A23-B6-C24;
A23-B6-C30;
A23-B6-C36;
A23-BC-C42;
A24-B6-C2;
A24-B6-C8;
A24-B6-C14;
A24-B6-C20;
A24-B6-C26;
A24-B6-C32;
A24-B6-C33;
A24-B6-C39;
A24-B6-C45;
A25-B6-C5;
A25-B6-C11;
A25-B6-C17;
A25-B6-C23;
A25-B6-C29;
A25-B6-C35;
A25-B6-C41;
A26-B6-C1;
A26-B6-C7;
A26-B6-C13;
A26-B6-C19;
A26-B6-C25;
A26-B6-C31;
A26-B6-C37;
A26-B6-C43;
A27-B6-C3;
A27-B6-C9;
A27-B6-C15;
A27-B6-C21;
A27-B6-C27;
A27-B6-C33;
A27-B6-C39;
A27-B6-C45;
A28-B6-C5;
A28-B6-C11;
A28-B6-C17;
A28-B6-C23;
A28-B6-C29;
A28-B6-C35;
A28-B6-C41;
A1-B7-C1;
A1-B7-C7;
A1-B7-C13;
A1-B7-C19;
A1-B7-C25;
A1-B7-C31;
A1-B7-C37;
A1-B7-C43;
A2-B7-C3;
A2-B7-C9;
A2-B7-C15;
A2-B7-C21;
A2-37-C27;
A2-B7-C33;
A2-B7-C39;
A2-B7-C45;
A3-B7-C5;
A3-B7-C11;
A3-B7-C17;
A3-B7-C23;
A3-B7-C29;
A3-B7-C35;
A3-B7-C41;
A4-B7-C1;
A4-B7-C7;
A4-B7-C13;
A4-B7-C19;
A4-B7-C25;
A4-B7-C31;
A4-B7-C37;
A24-B6-C34;
A24-B6-C40;
A24-B6-C46;
A25-B6-C6;
A25-B6-C12;
A25-B6-C18;
A25-B6-C24;
A25-B6-C30;
A25-B6-C36;
A25-B6-C42;
A26-B6-C2;
A26-B6-C8;
A26-B6-C14;
A26-B6-C20;
A26-B6-C26;
A26-B6-C32;
A26-B6-C38;
A26-B6-C44;
A27-B6-C4;
A27-B6-C10;
A27-B6-C16;
A27-B6-C22;
A27-B6-C28;
A27-B6-C34;
A27-B6-C40;
A27-B6-C46;
A28-B6-C6;
A28-B6-C12;
A28-B6-C18;
A28-B6-C24;
A28-B6-C30;
A28-B6-C36;
A28-B6-C42;
A1-B7-C2;
A1-B7-C8;
A1-B7-C14;
A1-B7-C20;
A1-B7-C26;
A1-B7-C32;
A1-B7-C38;
A1-B7-C44;
A2-37-C4;
A2-B7-C10;
A2-B7-C16;
A2-B7-C22;
A2-B7-C28;
A2-B7-C34;
A2-B7-C40;
A2-B7-C46;
A3-B7-C6;
A3-B7-C12;
A3-B7-C18;
A3-B7-C24;
A3-B7-C30;
A3-B7-C36;
A3-B7-C42;
A4-37-C2;
A4-B7-C8;
A4-B7-C14;
A4-B7-C20;
A4-B7-C26;
A4-B7-C32;
A4-37-C38;
A24-B6-C35;
A24-B6-C41;
A25-B6-C1;
A25-B6-C7;
A25-B6-C13;
A25-B6-C19;
A25-B6-C25;
A25-B6-C31;
A25-B6-C37;
A25-B6-C43;
A26-B6-C3;
A26-B6-C9;
A26-B6-C15;
A26-B6-C21;
A26-B6-C27;
A26-B6-C33;
A26-B6-C39;
A26-B6-C45; A27-B6-C5;
A27-B6-CU;
A27-B6-C17;
A27-B6-C23;
A27-B6-C29;
A27-B6-C35;
A27-B6-C41;
A28-B6-C1;
A28-36-C7;
A28-B6-C13;
A28-B6-C19;
A28-B6-C25;
A28-B6-C31;
A28-B6-C37;
A28-B6-C43;
A1-B7-C3;
A1-B7-C9;
A1-B7-C15;
A1-B7-C21;
A1-B7-C27;
A1-B7-C33;
A1-B7-C39;
A1-B7-C45;
A2-B7-C5;
A2-B7-C11;
A2-B7-C17;
A2-B7-C23;
A2-B7-C29;
A2-B7-C35;
A2-B7-C41;
A3-B7-C1;
A3-B7-C7;
A3-B7-C13;
A3-B7-C19;
A3-B7-C25;
A3-B7-C31;
A3-B7-C37;
A3-B7-C43;
A4-B7-C3;
A4-B7-C9;
A4-B7-C15;
A4-B7-C21;
A4-B7-C27;
A4-B7-C33;
A4-B7-C39;
A24-B6-C36; A24-B6-C42; A25-B6-C2;
A25-B6-C8;
A25-B6-C14;
A25-B6-C20;
A25-36-C26;
A25-36-C32;
A25-36-C38;
A25-B6-C44;
A26-B6-C4;
A26-36-C10;
A26-36-C16;
A26-B6-C22;
A26-B6-C28;
A26-B6-C34;
A26-B6-C40;
A26-36-C46;
A27-36-C6;
A27-B6-C12;
A27-36-C18;
A27-B6-C24;
A27-B6-C30;
A27-B6-C36;
A27-B6-C42;
A28-B6-C2;
A28-36-C8;
A28-B6-C14;
A28-B6-C20;
A28-36-C26;
A28-B6-C32;
A28-B6-C38;
A28-B6-C44;
A1-37-C4;
A1-B7-C10;
A1-B7-C16;
A1-B7-C22;
A1-37-C28;
A1-B7-C34;
A1-37-C40;
A1-B7-C46;
A2-B7-C6;
A2-B7-C12;
A2-B7-C18;
A2-B7-C24;
A2-B7-C30;
A2-B7-C36;
A2-B7-C42;
A3-B7-C2;
A3-B7-C8;
A3-B7-C14;
A3-B7-C20;
A3-37-C26;
A3-B7-C32;
A3-B7-C38;
A3-B7-C44;
A4-B7-C4;
A4-B7-C10;
A4-B7-C16;
A4-B7-C22;
A4-B7-C28;
A4-B7-C34;
A4-B7-C40;
A24-B6-C37;
A24-B6-C43;
A25-B6-C3;
A25-B6-C9;
A25-B6-C15;
A25-B6-C21;
A25-B6-C27;
A25-B6-C33;
A25-B6-C39;
A25-B6-C45; A26-B6-C5;
A26-B6-C11;
A26-B6-C17;
A26-B6-C23;
A26-B6-C29;
A26-B6-C35;
A26-B6-C41;
A27-B6-C1;
A27-B6-C7;
A27-B6-C13;
A27-B6-C19;
A27-B6-C25;
A27-B6-C31;
A27-B6-C37;
A27-B6-C43;
A28-B6-C3;
A28-B6-C9;
A28-B6-C15;
A28-B6-C21;
A28-B6-C27;
A28-B6-C33;
A28-B6-C39;
A28-B6-C45; A1-B7-C5;
A1-B7-C11;
A1-B7-C17;
A1-B7-C23;
A1-37-C29;
A1-37-C35;
A1-B7-C41; A2-B7-C1;
A2-B7-C7;
A2-B7-C13;
A2-B7-C19;
A2-B7-C25;
A2-B7-C31;
A2-B7-C37;
A2-B7-C43;
A3-B7-C3;
A3-B7-C9;
A3-B7-C15;
A3-B7-C21;
A3-B7-C27;
A3-B7-C33;
A3-B7-C39;
A3-B7-C45;
A4-B7-C5;
A4-B7-C11;
A4-B7-C17;
A4-B7-C23;
A4-B7-C29;
A4-B7-C35;
A4-B7-C41;
A24-B6-C38;
A24-B6-C44;
A25-B6-C4;
A25-B6-C10;
A25-B6-C16;
A25-B6-C22;
A25-B6-C28;
A25-B6-C34;
A25-B6-C40;
A25-B6-C46;
A26-B6-C6;
A26-B6-C12;
A26-B6-C18;
A26-B6-C24;
A26-B6-C30;
A26-B6-C36;
A26-B6-C42;
A27-B6-C2;
A27-B6-C8;
A27-B6-C14;
A27-B6-C20;
A27-B6-C26;
A27-B6-C32;
A27-B6-C38;
A27-B6-C44;
A28-B6-C4;
A28-B6-C10;
A28-B6-C16;
A28-B6-C22;
A28-B6-C28;
A28-36-C34;
A28-B6-C40;
A28-E6-C46;
A1-B7-C6;
A1-B7-C12;
A1-B7-C18;
A1-B7-C24;
A1-37-C30;
A1-37-C36;
A1-B7-C42;
A2-37-C2;
A2-B7-C8;
A2-B7-C14;
A2-B7-C20;
A2-37-C26;
A2-B7-C32;
A2-B7-C38;
A2-B7-C44;
A3-B7-C4;
A3-B7-C10;
A3-B7-C16;
A3-B7-C22;
A3-B7-C28;
A3-B7-C34;
A3-B7-C40;
A3-B7-C46;
A4-B7-C6;
A4-B7-C12;
A4-B7-C18;
A4-B7-C24;
A4-B7-C30;
A4-B7-C36;
A4-B7-C42;
<td>A4-B7-C43;</td><td>A4-B7-C44;</td><td>A4-B7-C45;</td><td>A4-B7-C46;</td><td>A5-B7-C1;</td><td>A5-B7-C2;</td>
<td>A5-B7-C3;</td><td>A5-B7-C4;</td><td>A5-B7-C5;</td><td>A5-B7-C6;</td><td>A5-B7-C7;</td><td>A5-B7-C8;</td>
<td>A5-B7-C9;</td><td>A5-B7-C10;</td><td>A5-B7-C11;</td><td>A5-B7-C12;</td><td>A5-B7-C13;</td><td>A5-B7-C14;</td>
<td>A5-B7-C15;</td><td>A5-B7-C16;</td><td>A5-B7-C17;</td><td>A5-B7-C18;</td><td>A5-B7-C19;</td><td>A5-B7-C20;</td>
<td>A5-B7-C21;</td><td>A5-E7-C22;</td><td>A5-B7-C23;</td><td>A5-B7-C24;</td><td>A5-B7-C25;</td><td>A5-B7-C26;</td>
<td>A5-B7-C27;</td><td>A5-E7-C28;</td><td>A5-B7-C29;</td><td>A5-B7-C30;</td><td>A5-B7-C31;</td><td>A5-B7-C32;</td>
<td>A5-B7-C33;</td><td>A5-B7-C34;</td><td>A5-B7-C35;</td><td>A5-B7-C36;</td><td>A5-B7-C37;</td><td>A5-B7-C38;</td>
<td>A5-B7-C39;</td><td>A5-B7-C40;</td><td>A5-B7-C41;</td><td>A5-B7-C42;</td><td>A5-B7-C43;</td><td>A5-B7-C44;</td>
<td>A5-B7-C45;</td><td>A5-B7-C46;</td><td>A6-B7-C1;</td><td>A6-B7-C2;</td><td>A6-B7-C3;</td><td>A6-B7-C4;</td>
<td>A6-B7-C5;</td><td>A6-B7-C6;</td><td>A6-B7-C7;</td><td>A6-B7-C8;</td><td>A6-B7-C9;</td><td>A6-B7-C10;</td>
<td>A6-B7-C11;</td><td>A6-B7-C12;</td><td>A6-B7-C13;</td><td>A6-B7-C14;</td><td>A6-B7-C15;</td><td>A6-B7-C16;</td>
<td>A6-B7-C17;</td><td>A6-B7-C18;</td><td>A6-B7-C19;</td><td>A6-B7-C20;</td><td>A6-B7-C21;</td><td>A6-B7-C22;</td>
<td>A6-37-C23;</td><td>A6-B7-C24;</td><td>A6-B7-C25;</td><td>A6-B7-C26;</td><td>A6-B7-C27;</td><td>A6-B7-C28;</td>
<td>A6-B7-C29;</td><td>A6-E7-C30;</td><td>A6-B7-C31;</td><td>A6-B7-C32;</td><td>A6-B7-C33;</td><td>A6-B7-C34;</td>
<td>A6-B7-C35;</td><td>A6-37-C36;</td><td>A6-B7-C37;</td><td>A6-B7-C38;</td><td>A6-B7-C39;</td><td>A6-B7-C40;</td>
<td>A6-B7-C41;</td><td>A6-B7-C42;</td><td>A6-B7-C43;</td><td>A6-B7-C44;</td><td>A6-B7-C45;</td><td>A6-B7-C46;</td>
<td>A7-B7-C1;</td><td>A7-37-C2;</td><td>A7-B7-C3;</td><td>A7-B7-C4;</td><td>A7-B7-C5;</td><td>A7-B ^ -C 6;</td>
<td>A7-B7-C7;</td><td>A7-B7-C8;</td><td>A7-B7-C9;</td><td>A7-B7-C10;</td><td>A7-B7-C11;</td><td>A7-B7-C12;</td>
<td>A7-B7-C13;</td><td>A7-37-C14;</td><td>A7-B7-C15;</td><td>A7-B7-C16;</td><td>A7-B7-C17;</td><td>A7-B7-C18;</td>
<td>A7-B7-C19;</td><td>A7-37-C20;</td><td>A7-B7-C21;</td><td>A7-B7-C22;</td><td>A7-B7-C23;</td><td>A7-B7-C24;</td>
<td>A7-B7-C25;</td><td>A7-B7-C26;</td><td>A7-B7-C27;</td><td>A7-B7-C28;</td><td>A7-B7-C29;</td><td>A7-B7-C30;</td>
<td>A7-B7-C31;</td><td>A7-37-C32;</td><td>A7-B7-C33;</td><td>A7-B7-C34;</td><td>A7-B7-C35;</td><td>A7-B7-C36;</td>
<td>A7-B7-C37;</td><td>A7-B7-C38;</td><td>A7-B7-C39;</td><td>A7-B7-C40;</td><td>A7-B7-C41;</td><td>A7-B7-C42;</td>
<td>A7-B7-C43;</td><td>A7-B7-C44;</td><td>A7-B7-C45;</td><td>A7-B7-C46;</td><td>A8-B7-C1;</td><td>A8-B7-C2;</td>
<td>A8-B7-C3;</td><td>A8-B7-C4;</td><td>A8-B7-C5;</td><td>A8-B7-C6;</td><td>A8-B7-C7;</td><td>A8-B7-C8;</td>
<td>A8-B7-C9;</td><td>A8-B7-C10;</td><td>A8-B7-C11;</td><td>A8-B7-C12;</td><td>A8-B7-C13;</td><td>A8-B7-C14;</td>
<td>A8-37-C15;</td><td>A8-B7-C16;</td><td>A8-B7-C17;</td><td>A8-B7-C18;</td><td>A8-B7-C19;</td><td>A8-37-C20;</td>
<td>A8-B7-C21;</td><td>A8-B7-C22;</td><td>A8-B7-C23;</td><td>A8-B7-C24;</td><td>A8-B7-C25;</td><td>A8-B7-C26;</td>
<td>A8-B7-C27;</td><td>A8-B7-C28;</td><td>A8-B7-C29;</td><td>A8-B7-C30;</td><td>A8-B7-C31;</td><td>A8-B7-C32;</td>
<td>A8-B7-C33;</td><td>A3-B7-C34;</td><td>A8-B7-C35;</td><td>A8-B7-C36;</td><td>A3-B7-C37;</td><td>A8-B7-C38;</td>
<td>A8-B7-C39;</td><td>A8-B7-C40;</td><td>A8-B7-C41;</td><td>A8-B7-C42;</td><td>A8-B7-C43;</td><td>A8-37-C44;</td>
<td>A8-B7-C45;</td><td>A8-B7-C46;</td><td>A9-B7-C1;</td><td>A9-B7-C2;</td><td>A9-B7-C3;</td><td>A9-37-C4;</td>
<td>A9-B7-C5;</td><td>A9-B7-C6;</td><td>A9-B7-C7;</td><td>A9-B7-C8;</td><td>A9-B7-C9;</td><td>A9-37-C10;</td>
<td>A9-B7-C11;</td><td>A9-B7-C12;</td><td>A9-B7-C13;</td><td>A9-B7-C14;</td><td>A9-B7-C15;</td><td>A9-3<sup>?</sup>-C16;</td>
<td>A9-B7-C17;</td><td>A9-B7-C18;</td><td>A9-B7-C19;</td><td>A9-B7-C20;</td><td>A9-B7-C21;</td><td>A9-B7-C22;</td>
<td>A9-B7-C23;</td><td>A9-37-C24;</td><td>A9-B7-C25;</td><td>A9-B7-C26;</td><td>A9-B7-C27;</td><td>A9-37-C28;</td>
<td>A9-B7-C29;</td><td>A9-37-C30;</td><td>A9-B7-C31;</td><td>A9-B7-C32;</td><td>A9-B7-C33;</td><td>A9-37-C34;</td>
<td>A9-B7-C35;</td><td>A9-37-C36;</td><td>A9-B7-C37;</td><td>A9-B7-C38;</td><td>A9-B7-C39;</td><td>A9-37-C40;</td>
<td>A9-B7-C41;</td><td>A9-B7-C42;</td><td>A9-B7-C43;</td><td>A9-B7-C44;</td><td>A9-B7-C45;</td><td>A9-37-C46;</td>
<td>A10-B7-C1;</td><td>A10-B7-C2;</td><td>A10-B7-C3; </td><td>A10-B7-C4;</td><td>A10-B7-C5;</td><td>Al 0<sup>_</sup>B7-C6;</td>
<td>A10-B7-C7;</td><td>A10-37-C8;</td><td>A10-B7-C9;</td><td>A10-B7-C10;</td><td>A10-B7-C11;</td><td>A10-B7-C12;</td>
<td>A10-B7-C13;</td><td>A10-B7-C14;</td><td>A10-B7-C15;</td><td>A10-B7-C16;</td><td>A10-B7-C17;</td><td>A1C-37-C 18;</td>
<td>A10-B7-C19;</td><td>A10-37-C20;</td><td>A10-B7-C21;</td><td>A10-B7-C22;</td><td>A10-B7-C23;</td><td>A10-E7-C24;</td>
<td>A10-B7-C25;</td><td>A10-B7-C26;</td><td>A10-B7-C27;</td><td>A10-B7-C28;</td><td>A10-B7-C29;</td><td>A1C-37-C30;</td>
<td>A10-B7-C31;</td><td>A10-37-C32;</td><td>A10-B7-C33;</td><td>A10-B7-C34;</td><td>A10-B7-C35;</td><td>A10-37-C36;</td>
<td>A10-B7-C37;</td><td>A10-B7-C38;</td><td>A10-B7-C39;</td><td>A10-B7-C40;</td><td>A10-B7-C41;</td><td>A10-E7-C42;</td>
<td>A10-B7-C43;</td><td>A10-37-C44;</td><td>A10-B7-C45;</td><td>A10-B7-C46;</td><td>A11-B7-C1;</td><td>A11-B7-C2;</td>
<td>A11-B7-C3;</td><td>A11-37-C4; .</td><td>A11-B7-C5;</td><td>A11-B7-C6;</td><td>A11-B7-C7; </td><td>A11-37-C8;</td>
<td>A11-B7-C9;</td><td>A11-37-C10;</td><td>A11-B7-C11;</td><td>A11-B7-C12;</td><td>A11-B7-C13;</td><td>A11-B7-C14;</td>
<td>A11-B7-C15;</td><td>A11-E7-C16;</td><td>A11-B7-C17;</td><td>A11-B7-C18;</td><td>A11-B7-C19;</td><td>A11-37-C20;</td>
<td>A11-B7-C21;</td><td>A11-B7-C22;</td><td>A11-B7-C23;</td><td>A11-B7-C24;</td><td>A11-B7-C25;</td><td>A11-B7-C26;</td>
<td>A11-B7-C27;</td><td>A11-37-C28;</td><td>A11-B7-C29;</td><td>A11-B7-C30;</td><td>A11-B7-C31;</td><td>A11-E7-C32;</td>
<td>A11-B7-C33;</td><td>A11-37-C34;</td><td>A11-B7-C35;</td><td>A11-B7-C36;</td><td>A11-B7-C37;</td><td>A11-B7-C38;</td>
<td>A11-B7-C39;</td><td>A11-B7-C40;</td><td>A11-B7-C41;</td><td>A11-B7-C42;</td><td>A11-B7-C43;</td><td>A11-37-C44;</td>
<td>A11-B7-C45;</td><td>A11-37-C46;</td><td>A12-B7-C1;</td><td>A12-B7-C2;</td><td>A12-B7-C3;</td><td>A12-E7-C4;</td>
<td>A12-B7-C5;</td><td>A12-37-C6;</td><td>A12-B7-C7;</td><td>A12-B7-C8;</td><td>A12-B7-C9;</td><td>A12-B7-C10;</td>
<td>A12-B7-C11;</td><td>A12-B7-C12;</td><td>A12-B7-C13;</td><td>A12-B7-C14;</td><td>A12-B7-C15;</td><td>A12-B7-C16;</td>
<td>A12-B7-C17;</td><td>A12-B7-C18;</td><td>A12-B7-C19;</td><td>A12-B7-C20;</td><td>A12-B7-C21;</td><td>A12-B7-C22;</td>
<td>A12-B7-C23;</td><td>A12-B7-C24;</td><td>A12-B7-C25;</td><td>A12-B7-C26;</td><td>A12-B7-C27;</td><td>A12-B7-C28;</td>
<td>A12-B7-C29;</td><td>A12-37-C30;</td><td>A12-B7-C31;</td><td>A12-B7-C32;</td><td>A12-B7-C33;</td><td>A12-B7-C34;</td>
<td>A12-B7-C35;</td><td>A12-37-C36;</td><td>A12-B7-C37;</td><td>A12-B7-C38;</td><td>A12-B7-C39;</td><td>A12-B7-C40;</td>
<td>A12-B7-C41;</td><td>A12-B7-C42;</td><td>A12-B7-C43;</td><td>A12-B7-C44;</td><td>A12-B7-C45;</td><td>A12-B7-C46;</td>
<td>A13-B7-C1;</td><td>A13-B7-C2;</td><td>A13-B7-C3;</td><td>A13-B7-C4;</td><td>A13-B7-C5;</td><td>A13-B7-C6;</td>
A13-B7-C7;
A13-B7-C13;
A13-B7-C19;
A13-B7-C25;
A13-B7-C31;
A13-B7-C37;
A13-B7-C43;
A14-B7-C3;
A14-B7-C9;
A14-B7-C15;
A14-B7-C21;
A14-B7-C27;
A14-B7-C33;
A14-B7-C39;
A14-B7-C45;
A15-B7-C5;
A15-B7-C11;
A15-B7-C17;
A15-B7-C23;
A15-B7-C29;
A15-B7-C35;
A15-B7-C41;
A16-B7-C1;
A16-B7-C7;
A16-B7-C13;
A16-B7-C19;
A16-B7-C25;
A16-B7-C31;
A16-B7-C37;
A16-B7-C43;
A17-B7-C3;
A17-B7-C9;
A17-B7-C15;
A17-B7-C21;
A17-B7-C27;
A17-B7-C33;
A17-B7-C39;
A17-B7-C45;
A18-B7-C5;
A18-B7-C11;
A18-B7-C17;
A18-B7-C23;
A18-B7-C29;
A18-B7-C35;
A18-B7-C41;
A19-B7-C1; .
A19-3'-C7;
A19-B7-C13;
A19-B7-C19;
A19-B7-C25;
A19-B7-C31;
A19-B7-C37;
A19-B7-C43;
A20-B7-C3;
A20-B7-C9;
A20-B7-C15;
A20-B7-C21;
A20-B7-C27;
A20-B7-C33;
A20-B7-C39;
A20-B7-C45;
A21-B7-C5;
A21-B7-C11;
A13-B7-C8;
A13-B7-C14;
A13-B7-C20;
A13-B7-C26;
A13-B7-C32;
A13-B7-C38;
A13-B7-C44;
A14-B7-C4;
A14-B7-C10;
A14-B7-C16;
A14-B7-C22;
A14-B7-C28;
A14-B7-C34;
A14-B7-C40;
A14-B7-C46;
A15-B7-C6;
A15-B7-C12;
A15-B7-C18;
A15-B7-C24;
A15-B7-C30;
A15-B7-C36;
A15-B7-C42;
A16-B7-C2;
A16-B7-C8;
A16-B7-C14;
A16-B7-C20;
A16-B7-C26;
A16-B7-C32;
A16-B7-C38;
A16-B7-C44;
A17-B7-C4;
A17-B7-C10;
A17-B7-C16;
A17-B7-C22;
A17-B7-C28;
A17-B7-C34;
A17-B7-C40;
A17-B7-C46;
A18-B7-C6;
A18-B7-C12;
A18-B7-C18;
A18-B7-C24;
A18-B7-C30;
A18-B7-C36;
A18-B7-C42;
A19-B7-C2;
A19-B7-C8;
A19-B7-C14 ·;
A19-B7-C20;
A19-B7-C26;
A19-B7-C32;
A19-B7-C38;
A19-B7-C44;
A20-B7-C4;
A20-B7-C10;
A20-B7-C16;
A20-B7-C22;
A20-B7-C28;
A20-B7-C34;
A20-B7-C40;
A20-B7-C46;
A21-B7-C6;
A21-B7-C12;
A13-B7-C9;
A13-B7-C15;
A13-B7-C21;
A13-B7-C27;
A13-B7-C33;
A13-B7-C39;
A13-B7-C45;
A14-B7-C5;
A14-B7-C11;
A14-B7-C17;
A14-B7-C23;
A14-B7-C29;
A14-B7-C35;
A14-B7-C41;
A15-B7-C1;
A15-B7-C7;
A15-B7-C13;
A15-B7-C19;
A15-B7-C25;
A15-B7-C31;
A15-B7-C37;
A15-B7-C43;
A16-B7-C3;
A16-B7-C9;
A16-B7-C15;
A16-B7-C21;
A16-B7-C27;
A16-B7-C33;
A16-B7-C39;
A16-B7-C45;
A17-B7-C5;
A17-B7-C11;
A17-B7-C17;
A17-B7-C23;
A17-B7-C29;
A17-B7-C35;
A17-B7-C41;
A18-B7-C1;
A18-B7-C7;
A18-B7-C13;
A18-B7-C19;
A18-B7-C25;
A18-B7-C31;
A18-B7-C37;
A18-B7-C43;
A19-B7-C3;
A19-B7-C9;
A19-B7-C15;
A19-B7-C21;
A19-B7-C27;
A19-B7-C33;
A19-B7-C39;
A19-B7-C45;
A20-B7-C5;
A20-B7-C11;
A20-B7-C17;
A20-B7-C23;
A20-B7-C29;
A20-B7-C35;
A20-B7-C41;
A21-B7-C1;
A21-B7-C7;
A21-B7-C13;
A13-B7-C10;
A13-B7-C16;
A13-B7-C22;
A13-B7-C28;
A13-B7-C34;
A13-B7-C40;
A13-B7-C46;
A14-B7-C6;
A14-B7-C12;
A14-B7-C18;
A14-B7-C24;
A14-B7-C30;
A14-B7-C36;
A14-B7-C42;
A15-B7-C2;
A15-B7-C8;
A15-B7-C14;
A15-B7-C20;
A15-B7-C26;
A15-B7-C32;
A15-B7-C38;
A15-B7-C44;
A16-B7-C4; ·
A16-B7-C10;
A16-B7-C16;
A16-B7-C22;
A16-B7-C28;
A16-B7-C34;
A16-B7-C40;
A16-B7-C46; A17-B7-C6;
A17-B7-C12;
A17-B7-C18;
A17-B7-C24;
A17-B7-C30;
A17-B7-C36;
A17-B7-C42;
A18-B7-C2;
A18-B7-C8;
A18-B7-C14;
A18-B7-C20;
A18-B7-C26;
A18-B7-C32;
A18-B7-C38;
A18-B7-C44;
A19-B7-C4;
A19-B7-C10;
A19-B7-C16;
A19-B7-C22;
A19-B7-C28;
A19-B7-C34;
A19-B7-C40;
A19-B7-C46; A20-B7-C6;
A20-B7-C12;
A20-B7-C18;
A20-B7-C24;
A20-B7-C30;
A20-B7-C36;
A20-B7-C42;
A21-B7-C2;
A21-B7-C8;
A21-B7-C14;
A13-B7-C11;
A13-B7-C17;
A13-B7-C23;
A13-B7-C29;
A13-B7-C35;
A13-B7-C41;
A14-B7-C1;
A14-B7-C7;
A14-B7-C13;
A14-B7-C19;
A14-B7-C25;
A14-B7-C31;
A14-B7-C37;
A14-B7-C43;
A15-B7-C3;
A15-B7-C9;
A15-B7-C15;
A15-B7-C21;
A15-B7-C27;
A15-B7-C33;
A15-B7-C39;
A15-B7-C45;
A16-B7-C5;
A16-B7-C11;
A16-B7-C17;
A16-B7-C23;
A16-B7-C29;
A16-B7-C35;
A16-B7-C41;
A17-B7-C1;
A17-B7-C7;
A17-B7-C13;
A17-B7-C19;
A17-B7-C25;
A17-B7-C31;
A17-B7-C37;
A17-B7-C43;
A18-B7-C3;
A18-B7-C9;
A18-B7-C15;
A18-B7-C21;
A18-B7-C27;
A18-B7-C33;
A18-B7-C39;
A18-B7-C45;
A19-B7-C5;
A19-B7-C11;
A19-B7-C17;
A19-B7-C23;
A19-B7-C29;
A19-B7-C35;
A19-B7-C41;
A20-B7-C1;
A20-B7-C7;
A20-B7-C13;
A20-B7-C19;
A20-B7-C25;
A20-B7-C31;
A20-B7-C37;
A20-B7-C43;
A21-B7-C3;
A21-B7-C9;
A21-B7-C15;
A13-B7-C12;
A13-B7-C18;
A13-B7-C24;
A13-B7-C30;
A13-B7-C36;
A13-B7-C42;
A14-B7-C2;
A14-B7-C8;
A14-B7-C14;
A14-B7-C20;
A14-B7-C26;
A14-B7-C32;
A14-B7-C38;
A14-B7-C44;
A15-B7-C4;
A15-B7-C10;
A15-B7-C16;
A15-B7-C22;
A15-B7-C28;
A15-B7-C34;
A15-B7-C40;
A15-B7-C46;
A16-B7-C6;
A16-B7-C12;
A16-B7-C18;
A16-B7-C24;
A16-B7-C30;
A16-B7-C36;
A16-B7-C42;
A17-B7-C2;
A17-B7-C8;
A17-B7-C14;
A17-37-C20;
A17-37-C26;
A17-37-C32;
A17-3 ~ -C38;
A17-37-C44;
A18-B7-C4;
A18-B7-C10;
A18-37-C16;
A18-37-C22;
A18-B7-C28;
A18-B7-C34;
A18-B7-C40;
A18-37-C46;
A19-B7-C6;
A19-B7-C12;
A19-B7-C18;
A19-37-C24;
A19-B7-C30;
A19-B7-C36;
A19-B7-C42;
A20-B7-C2;
A20-B7-C8;
A20-B7-C14;
A20-B7-C20;
A20-B7-C26;
A20-37-C32;
A20-B7-C38;
A20-B7-C44;
A21-B7-C4;
A21-B7-C10;
A21-B7-C16;
A21-B7-C17;
A21-B7-C23;
A21-B7-C29;
A21-B7-C35;
A21-B7-C41;
A22-B7-C1;
A22-B7-C7;
A22-B7-C13;
A22-B7-C19;
A22-B7-C25;
A22-B7-C31;
A22-B7-C37;
A22-B7-C43;
A23-B7-C3;
A23-B7-C9;
A23-B7-C15;
A23-B7-C21;
A23-B7-C27;
A23-B7-C33;
A23-B7-C39;
A23-B7-C45;
A24-B7-C5;
A24-B7-C11;
A24-B7-C17;
A24-B7-C23;
A24-B7-C29;
A24-B7-C35;
A24-B7-C41;
A25-B7-C1;
A25-B7-C7;
A25-B7-C13;
A25-B7-C19;
A25-B7-C25;
A25-B7-C31;
A25-B7-C37;
A25-B7-C43;
A26-B7-C3;
A26-B7-C9;
A26-B7-C15;
A26-B7-C21;
A26-B7-C27;
A26-B7-C33;
A26 B7-C39;
A26-B7-C45;
A27-B7-C5;
A27-B7-C11;
A27-B7-C17;
A27 B7-C23;
A27-B7-C29;
A27-B7-C35;
A27-B7-C41;
A28-E7-C1;
A28-B7-C7;
A28-B7-C13;
A28-B7-C19;
A28-B7-C25;
A28-B7-C31;
A28-B7-C37;
A28-B7-C43;
A1-B8-C3;
A1-B8-C9;
A1-B8-C15;
A1-B8-C21;
A21-B7-C18;
A21-B7-C24;
A21-B7-C30;
A21-B7-C36;
A21-B7-C42;
A22-B7-C2;
A22-B7-C8;
A22-B7-C14;
A22-B7-C20;
A22-B7-C26;
A22-B7-C32;
A22-B7-C38;
A22-B7-C44; A23-B7-C4;
A23-B7-C10;
A23-B7-C16;
A23-B7-C22;
A23-B7-C28; A23-B7-C34;
A23-B7-C40;
A23-B7-C46; A24-B7-C6;
A24-B7-C12;
A24-B7-C18;
A24-B7-C24;
A24-B7-C30;
A24-B7-C36;
A24-B7-C42;
A25-B7-C2;
A25-B7-C8;
A25-B7-C14;
A25-B7-C20;
A25-B7-C26;
A25-B7-C32;
A25-B7-C38;
A25-B7-C44; A26-B7-C4;
A26-B7-C10;
A26-B7-C16;
A26-B7-C22;
A26-B7-C28;
A26-B7-C34;
A26-B7-C40;
A26-B7-C46; A27-B7-C6;
A27-B7-C12;
A27-B7-C18;
A27-B7-C2-4;
A27-B7-C30;
A27-B7-C36;
A27-B7-C42;
A28-B7-C2;
A28-B7-C8;
A28-B7-C14;
A28-B7-C20;
A28-B7-C26;
A28-B7-C32;
A28-B7-C38;
A28-B7-C44;
A1-B8-C4;
A1-B8-C10;
A1-B8-C16;
A1-B8-C22;
A21-B7-C19;
A21-B7-C25;
A21-B7-C31;
A21-B7-C37;
A21-B7-C43;
A22-B7-C3;
A22-B7-C9;
A22-B7-C15;
A22-B7-C21;
A22-B7-C27;
A22-B7-C33;
A22-B7-C39;
A22-B7-C45;
A23-B7-C5;
A23-B7-C11;
A23-B7-C17;
A23-B7-C23;
A23-B7-C29;
A23-B7-C35;
A23-B7-C41;
A24-B7-C1;
A24-37-C7;
A24-B7-C13;
A24-37-C19;
A24-B7-C25;
A24-37-C31;
A24-37-C37;
A24-B7-C43;
A25-B7-C3;
A25-B7-C9;
A25-37-C15;
A25-B7-C21;
A25-E7-C27;
A25-B7-C33;
A25-37-C39;
A25-37-C45;
A26-37-C5;
A26-37-C11;
A26-B7-C17;
A26-37-C23;
A26-37-C29;
A26-B7-C35;
A26-37-C41;
A27-B7-C1;
A27-37-C7;
A27-B7-C13;
A27-B7-C19;
A27-B7-C25;
A27-B7-C31;
A27-37-C37;
A27-B7-C43;
A28-B7-C3;
A28-37-C9;
A28-B7-C15;
A28-B7-C21;
A28-37-C27;
A28-37-C33;
A28-B7-C39;
A28-B7-C45;
A1-B8-C5;
A1-B8-C11;
A1-E8-C17;
A1-B8-C23;
A21-B7-C20;
A21-B7-C26;
A21-B7-C32;
A21-B7-C38;
A21-B7-C44;
A22-B7-C4;
A22-B7-C10;
A22-B7-C16;
A22-B7-C22;
A22-B7-C28;
A22-B7-C34;
A22-B7-C40;
A22-B7-C46;
A23-B7-C6;
A23-B7-C12;
A23-B7-C18;
A23-B7-C24;
A23-B7-C30;
A23-B7-C36;
A23-B7-C42;
A24-B7-C2;
A24-B7-C8;
A24-B7-C14;
A24-B7-C20;
A24-B7-C26;
A24-B7-C32;
A24-B7-C38;
A24-B7-C44;
A25-B7-C4;
A25-B7-C10;
A25-B7-C16;
A25-B7-C22;
A25-B7-C28;
A25-B7-C34;
A25-B7-C40;
A25-B7-C46;
'A26-B7-C6;
A26-B7-C12;
A26-B7-C18;
A26-B7-C24;
A26-B7-C30;
A26-B7-C36;
A26-B7-C42;
A27-B7-C2;
A27-B7-C8;
A27-B7-C14;
A27-B7-C20;
A27-B7-C26;
A27-B7-C32;
A27-B7-C38;
A27-B7-C44;
A28-B7-C4;
A28-B7-C10;
A28-B7-C16;
A28-B7-C22;
A28-B7-C28;
A28-B7-C34;
A28-B7-C40;
A28-B7-C46;
A1-B8-C6;
A1-B8-C12;
A1-B8-C18;
A1-B8-C24;
A21-B7-C21;
A21-B7-C27;
A21-B7-C33;
A21-B7-C39;
A21-B7-C45;
A22-B7-C5;
A22-B7-C11;
A22-B7-C17;
A22-B7-C23;
A22-B7-C29;
A22-B7-C35;
A22-C41-B7;
A23-B7-C1;
A23-B7-C7;
A23-B7-C13;
A23-B7-C19;
A23-B7-C25;
A23-B7-C31;
A23-B7-C37;
A23-B7-C43;
A24-B7-C3;
A24-B7-C9;
A24-B7-C15;
A24-B7-C21;
A24-B7-C27;
A24-B7-C33;
A24-B7-C39;
A24-B7-C45;
A25-B7-C5;
A25-B7-C11;
A25-B7-C17;
A25-B7-C23;
A25-B7-C29;
A25-B7-C35;
A25-B7-C41;
A26-B7-C1;
A26-B7-C7;
A26-B7-C13;
A26-B7-C19;
A26-B7-C25;
A26-B7-C31;
A26-B7-C37;
A26-B7-C43;
A27-B7-C3;
A27-B7-C9;
A27-B7-C15;
A27-B7-C21;
A27-B7-C27;
A27-B7-C33;
A27-B7-C39;
A27-B7-C45;
A28-B7-C5;
A28-B7-C11;
A28-B7-C17;
A28-B7-C23;
A28-B7-C29;
A28-B7-C35;
A28-B7-C41;
A1-B8-C1;
A1-B8-C7;
A1-B8-C13;
A1-B8-C19;
A1-B8-C25;
A21-B7-C22;
A21-B7-C28;
A21-B7-C34;
A21-B7-C40;
A21-B7-C46;
A22-B7-C6;
A22-B7-C12;
A22-B7-C18;
A22-B7-C24;
A22-B7-C30;
A22-B7-C36;
A22-B7-C42;
A23-B7-C2;
A23-B7-C8;
A23-B7-C14;
A23-B7-C20;
A23-B7-C26;
A23-B7-C32;
A23-B7-C38;
A23-B7-C44;
A24-B7-C4;
A24-B7-C10;
A24-B7-C16;
A24-B7-C22;
A24-B7-C28;
A24-B7-C34;
A24-B7-C40;
A24-B7-C46;
A25-B7-C6;
A25-B7-C12;
A25-B7-C18;
A25-B7-C24;
A25-B7-C30;
A25-B7-C36;
A25-B7-C42;
A26-B7-C2;
A26-37-C8;
A26-B7-C14;
A26-B7-C20;
A26-B7-C26;
A26-B7-C32;
A26-B7-C38;
A26-B7-C44;
A27-B7-C4;
A27-B7-C10;
A27-B7-C16;
A27-B7-C22;
A27-B7-C28;
A27-B7-C34;
A27-B7-C40;
A27-B7-C46;
A28-B7-C6;
A28-B7-C12;
A28-B7-C18;
A28-B7-C24;
A28-B7-C30;
A23-B7-C36;
Α2 8-37-C42;
A1-38-C2;
A1-B8-C8;
A1-B8-C14;
A1-B8-C20;
A1-B8-C26;
<td>A1-B8-C27;</td><td>A1-B8-C28;</td><td>A1-B8-C29;</td><td>A1-B8-C30;</td><td>A1-B8-C31;</td><td>A1-B8-C32;</td>
<td>A1-B8-C33;</td><td>A1-B8-C34;</td><td>A1-B8-C35;</td><td>A1-B8-C36;</td><td>A1-B8-C37;</td><td>A1-B8-C38;</td>
<td>A1-B8-C39;</td><td>A1-B8-C40;</td><td>A1-B8-C41;</td><td>A1-B8-C42;</td><td>A1-B8-C43;</td><td>A1-B8-C44;</td>
<td>A1-B8-C45;</td><td>A1-B8-C46;</td><td>A2-B8-C1;</td><td>A2-B8-C2;</td><td>A2-B8-C3;</td><td>A2-B8-C4;</td>
<td>A2-B8-C5;</td><td>A2-B8-C6;</td><td>A2-B8-C7;</td><td>A2-B8-C8;</td><td>A2-B8-C9;</td><td>A2-B8-C10;</td>
<td>A2-B8-C11;</td><td>A2-38-C12;</td><td>A2-B8-C13;</td><td>A2-B8-C14;</td><td>A2-B8-C15;</td><td>A2-B8-C16;</td>
<td>A2-B8-C17;</td><td>A2-B8-C18;</td><td>A2-B8-C19;</td><td>A2-B8-C20;</td><td>A2-B8-C21;</td><td>A2-B8-C22;</td>
<td>A2-B8-C23;</td><td>A2-B8-C24;</td><td>A2-B8-C25;</td><td>A2-B8-C26;</td><td>A2-B8-C27;</td><td>A2-B3-C28;</td>
<td>A2-B8-C29;</td><td>A2-B8-C30;</td><td>A2-B8-C31;</td><td>A2-B8-C32;</td><td>A2-B8-C33;</td><td>A2-B8-C34;</td>
<td>A2-B8-C35;</td><td>A2-38-C36; '</td><td>A2-B8-C37;</td><td>A2-B8-C38;</td><td>A2-B8-C39;</td><td>A2-B8-C40;</td>
<td>A2-B8-C41;</td><td>A2-38-C42;</td><td>A2-B8-C43;</td><td>A2-B8-C44;</td><td>A2-B8-C45;</td><td>A2-B8-C46;</td>
<td>A3-B8-C1;</td><td>A3-38-C2;</td><td>A3-B8-C3;</td><td>A3-B8-C4;</td><td>A3-B8-C5;</td><td>A3-B8-C6;</td>
<td>A3-B8-C7;</td><td>A3-38-C8;</td><td>A3-B8-C9;</td><td>A3-B8-C10;</td><td>A3-B8-C11;</td><td>A3-B3-C12;</td>
<td>A3-B8-C13;</td><td>A3-38-C14;</td><td>A3-B8-C15;</td><td>A3-B8-C16;</td><td>A3-B8-C17;</td><td>A3-B8-C18;</td>
<td>A3-B8-C19;</td><td>A3-38-C20;</td><td>A3-B8-C21;</td><td>A3-B8-C22;</td><td>A3-B8-C23;</td><td>A3-B8-C24;</td>
<td>A3-B8-C25;</td><td>A3-38-C26;</td><td>A3-B8-C27;</td><td>A3-B8-C28;</td><td>A3-B8-C29;</td><td>A3-B8-C30;</td>
<td>A3-B8-C31;</td><td>A3-B8-C32;</td><td>A3-B8-C33;</td><td>A3-B8-C34;</td><td>A3-B8-C35;</td><td>A3-B8-C36;</td>
<td>A3-B8-C37;</td><td>A3-38-C38;</td><td>A3-B8-C39;</td><td>A3-B8-C40;</td><td>A3-B8-C41;</td><td>A3-B8-C42;</td>
<td>A3-B8-C43;</td><td>A3-38-C44;</td><td>A3-B8-C45;</td><td>A3-B8-C46;</td><td>A4-B8-C1;</td><td>A4-B8-C2;</td>
<td>A4-B8-C3;</td><td>A4-38-C4;</td><td>A4 B8-C5;</td><td>A4-B8-C6;</td><td>A4-B8-C7;</td><td>A4-B8-C8;</td>
<td>A4-B8-C9;</td><td>A4-38-C10;</td><td>A4 B8-C11;</td><td>A4-B8-C12;</td><td>A4 B8-C13;</td><td>A4 B8-C14;</td>
<td>A4 B8-C15;</td><td>A4-38-C16;</td><td>A4 B8-C17;</td><td>A4-B8-C18;</td><td>A4 B8-C19;</td><td>A4 B8-B20;</td>
<td>A4 B8-C21;</td><td>A4-38-C22;</td><td>A4 B8-C23;</td><td>A4 B8-C24;</td><td>A4 B8-C25;</td><td>A4 B8-C26;</td>
<td>A4 B8-C27;</td><td>A4-38-C28;</td><td>A4 B8-C29;</td><td>A4 B8-C30;</td><td>A4 B8-C31;</td><td>A4 B8-C32;</td>
<td>A4 B8-C33;</td><td>A4 B8-C34;</td><td>A4 B8-C35;</td><td>A4 B8-C36;</td><td>A4 B8-C37;</td><td>A4-B3-C38;</td>
<td>A4 B8-C39;</td><td>A4 B8-C40;</td><td>A4 B8-C41;</td><td>A4 B8-C42;</td><td>A4 B8-C43;</td><td>4 4 -B 3 -C 4 4;</td>
<td>A4 B8-C45;</td><td>A4 B8-C46;</td><td>A5-B8-C1;</td><td>A5-B8-C2;</td><td>A5-B8-C3;</td><td>A5-38-C4;</td>
<td>A5-B8-C5;</td><td>A5-B8-C6;</td><td>A5-B8-C7;</td><td>A5-B8-C8;</td><td>A5-B8-C9;</td><td>A5-B8-C10;</td>
<td>A5-B8-C11;</td><td>A5-B8-C12;</td><td>A5-B8-C13;</td><td>A5-B8-C14;</td><td>A5-B8-C15;</td><td>A5-38-C16;</td>
<td>A5-B8-C17;</td><td>A5-38-C18;</td><td>A5-B8-C19;</td><td>A5-B8-C20;</td><td>A5-B8-C21;</td><td>A5-33-C22;</td>
<td>A5-B8-C23;</td><td>A5-38-C24;</td><td>A5-B8-C25;</td><td>A5-B8-C26;</td><td>A5-B8-C27;</td><td>A5-33-C28;</td>
<td>A5-B8-C29;</td><td>A5-B8-C30;</td><td>A5-B8-C31;</td><td>A5-B8-C32;</td><td>A5-B8-C33;</td><td>A5-38-C34;</td>
<td>A5-B8-C35;</td><td>A5-B8-C36;</td><td>A5-B8-C37;</td><td>A5-B8-C38;</td><td>A5-B8-C39;</td><td>A5-38-C40;</td>
<td>A5-B8-C41;</td><td>A5-BS-C42;</td><td>A5-B8-C43;</td><td>A5-B8-C44;</td><td>A5-B8-C45;</td><td>A5-33-C46;</td>
<td>A6-B8-C1;</td><td>A6-B8-C2;</td><td>A6-B8-C3;</td><td>A6-B8-C4;</td><td>A6-B8-C5;</td><td>A6-3S-C6;</td>
<td>A6-B8-C7;</td><td>A6-B8-C8;</td><td>A6-B8-C9;</td><td>A6-B8-C10;</td><td>A6-B8-C11;</td><td>A6-33-C12;</td>
<td>A6-B8-C13;</td><td>A6-38-C14;</td><td>A6-B8-C15;</td><td>A6-B8-C16;</td><td>A6-B8-C17;</td><td>A6-B3-C18;</td>
<td>A6-B8-C19;</td><td>A6-38-C20;</td><td>A6-B8-C21;</td><td>A6-B8-C22;</td><td>A6-B8-C23;</td><td>A6-33-C24;</td>
<td>A6-B8-C25;</td><td>A6-38-C26;</td><td>A6-B8-C27;</td><td>A6-B8-C28;</td><td>A6-B8-C29;</td><td>A6-38-C30;</td>
<td>A6-B8-C31;</td><td>A6-38-C32;</td><td>A6-B8-C33;</td><td>A6-B8-C34;</td><td>A6-B8-C35;</td><td>A6-38-C36;</td>
<td>A6-B8-C37;</td><td>A6-38-C38;</td><td>A6-B8-C39;</td><td>A6-B8-C40;</td><td>A6-B8-C41;</td><td>A6-38-C42;</td>
<td>A6-B8-C43;</td><td>A6-39-C44;</td><td>A6-B8-C45;</td><td>A6-B8-C46;</td><td>A7-B8-C1;</td><td>A7-33-C2;</td>
<td>A7-B8-C3;</td><td>A7-38-C4;</td><td>A7-B8-C5;</td><td>A7-B8-C6;</td><td>A7-B8-C7;</td><td>A7-B3-C8;</td>
<td>A7-B8-C9;</td><td>A7-B8-C10;</td><td>A7-B8-C11;</td><td>A7-B8-C12;</td><td>A7-B8-C13;</td><td>A7-38-C14;</td>
<td>A7-B8-C15;</td><td>A7-38-C16;</td><td>A7-B8-C17;</td><td>A7-B8-C18;</td><td>A7-B8-C19;</td><td>A7-38-C20;</td>
<td>A7-B8-C21;</td><td>A7-38-C22;</td><td>A7-B8-C23;</td><td>A7-B8-C24;</td><td>A7-B8-C25;</td><td>A7-38-C26;</td>
<td>A7-B8-C27;</td><td>A7-B8-C28;</td><td>A7-B8-C29;</td><td>A7-B8-C30;</td><td>A7-B8-C31;</td><td>A7-33-C32;</td>
<td>A7-B8-C33;</td><td>A7-38-C34 ;.</td><td>A7-B8-C35;</td><td>'A7-B8-C36;</td><td>A7-B8-C37;</td><td>A7-33-C38;</td>
<td>A7-B8-C39;</td><td>A7-B8-C40;</td><td>A7-B8-C41;</td><td>A7-B8-C42;</td><td>A7-B8-C43;</td><td>A7-B8-C44;</td>
<td>A7-B8-C45;</td><td>A7-38-C46;</td><td>A8-B8-C1;</td><td>A8-B8-C2;</td><td>A8-B8-C3;</td><td>A3-38-C4;</td>
<td>A8-B8-C5;</td><td>A8-38-C6;</td><td>A8-B8-C7;</td><td>A8-B8-C8;</td><td>A8-B8-C9;</td><td>A8-38-C10;</td>
<td>A8-B8-C11;</td><td>A8-B8-C12;</td><td>A8-B8-C13;</td><td>A8-B8-C14;</td><td>A8-B8-C15;</td><td>A8-B8-C16;</td>
<td>A8-B8-C17;</td><td>A8-B8-C18;</td><td>A8-B8-C19;</td><td>A8-B8-C20;</td><td>A8-B8-C21;</td><td>A8-38-C22;</td>
<td>A8-B8-C23;</td><td>A8-38-C24;</td><td>A8-B8-C25;</td><td>A8-B8-C26;</td><td>A8-B8-C27;</td><td>A8-B8-C28;</td>
<td>A8-B8-C29;</td><td>A8-38-C30;</td><td>A8-B8-C31;</td><td>A8-B8-C32;</td><td>A8-B8-C33;</td><td>A8-3S-C34;</td>
<td>A8-B8-C35;</td><td>A8-B8-C36;</td><td>A8-B8-C37;</td><td>A8-B8-C38;</td><td>A8-B8-C39;</td><td>A8-38-C40;</td>
<td>A8-B8-C41;</td><td>A8-38-C42;</td><td>A8-B8-C43;</td><td>A8-B8-C44;</td><td>A8-B8-C45;</td><td>A8-38-C46;</td>
<td>A9-B8-C1;</td><td>A9-38-C2;</td><td>A9-B8-C3;</td><td>A9-B8-C4;</td><td>A9-B8-C5;</td><td>A9-38-C6;</td>
<td>A9-B8-C7;</td><td>A9-38-C8;</td><td>A9-B8-C9;</td><td>A9-B8-C10;</td><td>A9-B8-C11;</td><td>A9-38-C12;</td>
<td>A9-B8-C13;</td><td>A9-B8-C14;</td><td>A9-B8-C15;</td><td>A9-B8-C16;</td><td>A9-B8-C17;</td><td>A9-B8-C18;</td>
<td>A9-B8-C19;</td><td>A9-38-C20;</td><td>A9-B8-C21;</td><td>A9-B8-C22;</td><td>A9-B8-C23;</td><td>A9-B8-C24;</td>
<td>A9-B8-C25;</td><td>A9-38-C26;</td><td>A9-B8-C27;</td><td>A9-B8-C28;</td><td>A9-B8-C29;</td><td>A9-B8-C30;</td>
<td>A9-B8-C31;</td><td>A9-38-C32;</td><td>A9-B8-C33;</td><td>A9-B8-C34;</td><td>A9-B8-C35;</td><td>A9-B8-C36;</td>
A9-B8-C37;
A9-B8-C43;
A10-B8-C3;
A10-B8-C9;
A10-B8-C15;
A10-B8-C21;
A10-B8-C27;
A10-B8-C33;
A10-B8-C39;
A10-B8-C45;
A11-B8-C5;
A1i-B8-C11;
A11-B8-C17;
A11-B8-C23;
A11-B8-C29;
A11-B8-C35;
A11-B8-C41;
A12-B8-C1;
A12-B8-C7;
A12-B8-C13;
A12-B8-C19;
A12-B8-C25;
A12-B8-C31;
A12-B8-C37;
A12-B8-C43;
A13-B8-C3;
A13-B8-C9;
A13-B8-C15;
A13-B8-C21;
A13-B8-C27;
A13-B8-C33;
A13-B8-C39;
A13-B8-C45; A14-B8-C5;
A14-B8-C11;
A14-B8-C17;
A14-B8-C23;
A14-B8-C29; Α14-B8-C35;
A14-B8-C41;
A15-B8-C1;
£ Al-B8-C7;
A15-B8-C13;
A15-B8-C19;
A15-B8-C25;
A15-B8-C31;
A15-B8-C37;
A15-B8-C43; AL6-B8-C3; A16-B8-C9;
A16-B8-C15;
A16-B8-C21;
A16-B8-C27;
A16-B8-C33;
A16-B8-C39;
A16-B8-C45; A17-B8-C5;
A17-B8-C11;
A17-B8-C17;
A17-B8-C23;
A17-B8-C29;
A17-B8-C35;
A17-B8-C41;
A9-B8-C38;
A9-B8-C44;
A10-B8-C4;
A10-B8-C10;
A10-B8-C16;
A10-B8-C22;
A10-38-C28;
A10-B8-C34;
A10-B8-C40;
A10-B8-C46;
A11-B8-C6;
A11-B8-C12;
A11-38-C18;
A11-B8-C24;
A11-B8-C30;
A11-B8-C36;
A11-38-C42;
A12-B8-C2;
A12-B8-C8;
A12-B8-C14;
A12-38-C20;
A12-B8-C26;
A12-B8-C32;
A12-38-C38;
A12-38-C44; A13-B8-C4;
A13-B8-C10;
A13-B8-C16;
A13-B8-C22;
A13-B8-C28;
A13-B8-C34;
A13-B8-C40;
A13-B8-C46;
A14-B8-C6;
A14-B8-C12;
A14-38-C18;
A14-B8-C24;
A14-B8-C30;
A14-B8-C36;
A14-B8-C42;
A15-38-C2;
A15-B8-C8;
A15-38-C14;
A15-B8-C20;
A15-38-C26;
A15-B8-C32;
A15-38-C38;
A15-B8-C44 ·;
A16-B8-C4;
A16-38-C10;
A16-38-C16;
A16-38-C22;
A16-B8-C28;
A16-B8-C34;
A16 B8-C40;
A16-B8-C46;
A17-B8-C6;
A17-B8-C12;
A17-38-C18;
A17-B8-C24;
A17-38-C30;
A17-B8-C36;
A17-B8-C42;
A9-B8-C39;
A9-B8-C45;
A10-B8-C5;
A10-B8-C11;
A10-B8-C17;
A10-B8-C23;
A10-B8-C29;
A10-B8-C35;
A10-B8-C41;
A11-B8-C1;
A11-B8-C7;
A11-B8-C13;
A11-B8-C19;
A11-B8-C25;
A11-B8-C31;
A11-B8-C37;
A11-B8-C43;
A12-B8-C3;
A12-B8-C9;
A12-B8-C15;
A12-B8-C21;
A12-38-C27;
A12-B8-C33;
A12-B8-C39;
A12-B8-C45; A13-B8-C5;
A13-B8-C11;
A13-B8-C17;
A13-B8-C23;
A13-B8-C29;
A13-B8-C35;
A13-B8-C41;
A14-B8-C1;
A14-B8-C7;
A14-B8-C13;
A14-B8-C19;
A14-B8-C25;
A14-B8-C31;
A14-B8-C37;
A14-B8-C43;
A15-B8-C3;
A15-B8-C9;
A15-B8-C15;
A15-B8-C21;
A15-38-C27;
A15-B8-C33;
A15-38-C39;
A15-38-C45; A16-B8-C5;
A16-B8-C11;
A16-B8-C17;
A16-B8-C23;
A16-B8-C29;
A16-B8-C35;
A16-B8-C41;
A17-B8-C1;
A17-B8-C7;
A17-B8-C13;
A17-B8-C19;
A17-B8-C25;
A17-B8-C31;
A17-B8-C37;
A17-B8-C43;
A9-B8-C40;
A9-B8-C46;
A10-B8-C6;
A10-B8-C12;
A10-B8-C18;
A10-B8-C24;
A10-B8-C30;
A10-B8-C36;
A10-B8-C42;
A11-B8-C2;
A11-B8-C8;
A11-B8-C14;
A11-B8-C20;
A11-B8-C26;
A11-B8-C32;
A11-B8-C38;
A11-B8-C44;
A12-B8-C4;
A12-B8-C10;
A12-B8-C16;
A12-B8-C22;
A12-B8-C28;
A12-B8-C34;
A12-B8-C40;
A12-B8-C46;
A13-B8-C6;
A13-B8-C12;
A13-B8-C18;
A13-B8-C24;
A13-B8-C30;
A13-B8-C36;
A13-B8-C42;
A14-B8-C2;
A14-B8-C8;
A14-B8-C14;
A14-B8-C20;
A14-B8-C26;
A14-B8-C32;
A14-B8-C38;
A14-B8-C44;
A15-B8-C4;
A15-B8-C10;
A15-B8-C16;
A15-B8-C22;
A15-B8-C28;
A15-B8-C34;
A15-B8-C40;
A15-B8-C46;
A16-B8-C6;
A16-B8-C12;
A16-B8-C18;
A16-B8-C24;
A16-B8-C30;
A16-B8-C36;
A16-B8-C42;
A17-B8-C2;
A17-B8-C8;
A17-B8-C14;
A17-B8-C20;
A17-B8-C26;
A17-B8-C32;
A17-B8-C38;
A17-B8-C44;
A9-B8-C41;
A10-B8-C1;
A10-B8-C7;
A10-B8-C13;
A10-B8-C19;
A10-B8-C25;
A10-B8-C31;
A10-B8-C37;
A10-B8-C43;
A11-B8-C3;
A11-B8-C9;
A11-B8-C15;
A11-B8-C21;
A11-B8-C27;
A11-B8-C33;
A11-B8-C39;
A11-B8-C45;
A12-B8-C5;
A12-B8-C11;
A12-B8-C17;
A12-B8-C23;
A12-B8-C29;
A12-B8-C35;
A12-B8-C41;
A13-B8-C1;
A13-B8-C7;
A13-B8-C13;
A13-B8-C19;
A13-B8-C25;
A13-B8-C31;
A13-B8-C37;
A13-B8-C43;
A14-B8-C3;
A14-B8-C9;
A14-B8-C15;
A14-B8-C21;
A14-B8-C27;
A14-B8-C33;
A14-B8-C39;
A14-B8-C45;
A15-B8-C5;
A15-B8-C11;
A15-B8-C17;
A15-B8-C23;
A15-B8-C29;
A15-B8-C35;
A15-B8-C41;
A16-B8-C1;
A16-B8-C7;
A16-B8-C13;
A16-B8-C19;
A16-B8-C25;
A16-B8-C31;
A16-B8-C37;
A16-B8-C43;
A17-B8-C3;
A17-B8-C9;
A17-B8-C15;
A17-B8-C21;
A17-B8-C27;
A17-B8-C33;
A17-B8-C39;
A17-B8-C45;
A9-B8-C42;
A10-B8-C2;
A10-B8-C8;
A1O-B8-C14;
A10-B8-C20;
A10-B8-C26;
A10-B8-C32;
A1O-BS-C38;
A1O-B8-C44;
A11-B8-C4;
A11-BS-C10;
A11-B8-C16;
A11-38-C22;
A11-BS-C28;
A11-3Š-C34;
A11-B8-C40;
A11-38-C46;
A12-B8-C6;
A12-B8-C12;
A12-38-C18;
A12-38-C24;
A12-B8-C30;
A12-38-C36;
A12-58-C42;
A13-38-C2;
A13-38-C8;
A13-B8-C14;
A13-38-C20;
A13-B8-C26;
A13-B8-C32;
A13-38-C38;
A13-B8-C44;
A14-B3-C4;
A14-BS-C10;
A14-B8-C16;
A14-BS-C22;
A14-38-C28;
A14-38-C34;
A14-38-C40;
A14-38-C46;
A15-B8-C6;
A15-38-C12;
A15-33-C18;
A15-38-C24;
A15-38-C30;
A15-38-C36;
A15-38-C42;
A16-38-C2;
A16-33-C8;
A16-B8-C14;
A16-38-C20;
A16-BS-C26;
A16-38-C32;
A16-38-C38;
A16-38-C44;
A17-B8-C4;
A17-B8-C10;
A17-38-C16;
A17-B8-C22;
A17-B8-C28;
A17-B8-C34;
A17-B8-C4O;
A17-B8-C46;
A18-B8-C1;
A18-B8-C7;
A18-B8-C13;
A18-B8-C19;
A18-B8-C25;
A18-B8-C31;
A18-B8-C37;
A18-B8-C43;
A19-B8-C3;
A19-B8-C9;
A19-B8-C15;
A19-B8-C21;
A19-B8-C27;
A19-B8-C33;
A19-B8-C39;
A19-B8-C45; A20-B8-C5;
A20-B8-C11;
A20-B8-C17;
A20-B8-C23;
A20-B8-C29;
A20-B8-C35;
A20-B8-C41;
A21-B8-C1;
A21-B8-C7;
A21-B8-C13;
A21-B8-C19;
A21-B8-C25;
A21-B8-C31;
A21-B8-C37;
A21-B8-C43;
A22-B8-C3;
A22-B8-C9;
A22-C15-B8;
A22-C21-B8;
A22-C27-B8;
A22-C33-B8;
A22-C39-B8;
A22-C45-B8;
A23-B8-C5;
A23-B8-C11;
A23-B8-C17;
A23-B8-C23;
A23-B8-C29;
A23 B8-C35;
A23-B8-C41;
A24-B8-C1;
A24-B8-C7;
A24-B8-C13;
A24-B8-C19;
A24-B8-C25;
A24-B8-C31;
A24-B8-C37;
A24-B8-C43;
A25-B8-C3;
A25-B8-C9;
A25-B8-C15;
A25-B8-C21;
A25-B8-C27;
A25-B8-C33;
A25-B8-C39;
A25-B8-C45;
A26-B8-C5;
A18-B8-C2;
A18-B8-C8;
A18-B8-C14;
A18-B8-C20;
A18-B8-C26;
A18-B8-C32;
A18-B8-C38;
A18-B8-C44;
A19-B8-C4;
A19-B8-C10;
A19-B8-C16;
A19-B8-C22;
A19-B8-C28;
A19-B8-C34;
A19-B8-C40;
A19-B8-C46;
A20-B8-C6;
A20-B8-C12;
A20-B8-C18;
A20-B8-C24;
A20-B8-C30;
A20-B8-C36;
A20-B8-C42;
A21-B8-C2;
A21-B8-C8;
A21-B8-C14;
A21-B8-C20;
A21-B8-C26;
A21-B8-C32;
A21-B8-C38;
A21-B8-C44;
A22-B8-C4;
A22-B8-C10;
A22-C16-B8;
A22-C22-B8;
A22-C28-B8;
A22-C34-B8;
A22-C40-B8;
A22-C46-B8;
A23-B8-C6;
A23-B8-C12;
A23-B8-C18;
A23-B8-C24;
A23-B8-C30;
A23-B8-C36;
A23-B8-C42;
A24-B8-C2;
A24-B8-C8;
A24-B8-C14;
A24-B8-C20;
A24-B8-C26;
A24-B8-C32;
A24-B8-C38;
A24-B8-C44;
A25-B8-C4;
A25-B8-C10;
A25-B8-C16;
A25-B8-C22;
A25-B8-C28;
A25-B8-C34;
A25-B8-C40;
A25-B8-C46;
A26-B8-C6;
A18-B8-C3;
A18-B8-C9;
A18-B8-C15;
A18-B8-C21;
A18-B8-C27;
A18-B8-C33;
A18-B8-C39;
A18-B8-C45;
A19-B8-C5;
A19-B8-C11;
A19-B8-C17;
A19-B8-C23;
A19-B8-C29;
A19-B8-C35;
A19-B8-C41;
A20-B8-C1;
A20-B8-C7;
A20-B8-C13;
A20-B8-C19;
A20-B8-C25;
A20-B8-C31;
A20-B8-C37;
A20-B8-C43;
A21-B8-C3;
A21-B8-C9;
A21-B8-C15;
A21-B8-C21;
A21-B8-C27;
A21-B8-C33;
A21-B8-C39;
A21-B8-C45;
A22-B8-C5;
A22-C11-B8;
A22-C17-B8;
A22-C23-B8;
A22-C29-B8;
A22-C35-B8;
A22-C41-B8;
A23-B8-C1;
A23-B8-C7;
A23-B8-C13;
A23-B8-C19;
A23-B8-C25;
A23-B8-C31;
A23-B8-C37;
A23-B8-C43;
A24-B8-C3;
A24-B8-C9;
A24-B8-C15;
A24-B8-C21;
A24-B8-C27;
A24-B8-C33;
A24-B8-C39;
A24-B8-C45;
A25-B8-C5;
A25-B8-C11;
A25-B8-C17;
A25-B8-C23;
A25-B8-C29;
A25-B8-C35;
A25-B8-C41; A26-B8-C1;
A26-B8-C7;
A18-B8-C4;
A18-B8-C10;
A18-B8-C16;
A18-B8-C22;
A18-B8-C28;
A18-B8-C34;
A18-B8-C40;
A18-B8-C46;
A19-B8-C6;
A19-B8-C12;
A19-B8-C18;
A19-B8-C24;
A19-B8-C30;
A19-B8-C36;
A19-B8-C42;
A20-B8-C2;
A20-B8-C8;
A20-B8-C14;
A20-B8-C20;
A20-B8-C26;
A20-B8-C32;
A20-B8-C38;
A20-B8-C44;
A21-B8-C4;
A21-B8-C10;
A21-B8-C16;
A21-B8-C22;
A21-B8-C28;
A21-B8-C34;
A21-B8-C40;
A21-B8-C46;
A22-B8-C6;
A22-B8-C12;
A22-B8-C18;
A22-C24-B8;
A22-C30-B8;
A22-C36-B8;
A22-C42-B8;
A23-B8-C2;
A23-B8-C8;
A23-B8-C14;
A23-B8-C20;
A23-B8-C26;
A23-B8-C32;
A23-B8-C38;
A23-B8-C44;
A24-B8-C4;
A24-B8-C10;
A24-B8-C16;
A24-B8-C22;
A24-B8-C28;
A24-B8-C34;
A24-B8-C40;
A24-B8-C46;
A25-B8-C6;
A25-B8-C12;
A25-B8-C18;
A25-B8-C24;
A25-B8-C30;
A25-B8-C36;
A25-B8-C42;
A26-B8-C2;
A26-B8-C8;
A18-B8-C5;
A18-B8-C11;
A18-B8-C17;
A18-B8-C23;
A18-B8-C29;
A18-B8-C35;
A18-B8-C41;
A19-B8-C1;
A19-B8-C7;
A19-B8-C13;
A19-B8-C19;
A19-B8-C25;
A19-B8-C31;
A19-B8-C37;
A19-B8-C43;
A20-B8-C3;
A20-B8-C9;
A20-B8-C15;
A20-B8-C21;
A20-B8-C27;
A20-B8-C33;
A20-B8-C39;
A20-B8-C45;
A21-B8-C5;
A21-B8-C11;
A21-B8-C17;
A21-B8-C23;
A21-B8-C29;
A21-B8-C35;
A21-B8-C41;
A22-B8-C1;
A22-B8-C7;
A22-C13-B8;
A22-C19-B8;
A22-C25-B8;
A22-C31-B8;
A22-C37-B8;
A22-C43-B8;
A23-B8-C3;
A23-B8-C9;
A23-B8-C15;
A23-B8-C21;
A23-B8-C27;
A23-B8-C33;
A23-B8-C39;
A23-B8-C45;
A24-B8-C5;
A24-B8-C11;
A24-B8-C17;
A24-B8-C23;
A24-B8-C29;
A24-B8-C35;
A24-B8-C41;
A25-B8-C1;
A25-B8-C7;
A25-B8-C13;
A25-B8-C19;
A25-B8-C25;
A25-B8-C31;
A25-B8-C37;
A25-B8-C43;
A26-B8-C3;
A26-B8-C9;
A18-B8-C6;
A18-B8-C12;
A18-B8-C18;
A18-B8-C24;
A18-B8-C30;
A18-B8-C36;
A18-B8-C42;
A19-B8-C2;
A19-B8-C8 ;.
A19-B8-C14;
A19-B8-C20;
A19-B8-C26;
A19-B8-C32;
A19-B8-C38;
A19-B8-C44; A20-B8-C4;
A20-B8-C10;
A20-B8-C16;
A20-B8-C22;
A20-B8-C28;
A20-B8-C34;
A20-B8-C40;
A20-B8-C46;
A21.-B8-C6;
A21-B8-C12;
A21-B8-C18;
A21-B8-C24;
A21-B8-C30;
A2, B8--C 36;
A21-B8-C42;
A22-B8-C2;
A22-B8-C8;
A22-C14-B8;
A22-B8-B20;
A22-C26-B8;
A22-C32-B8;
A22-C38-B8;
A22-C44-B8;
A23-B8-C4;
A23-B8-C10;
A23-B8-C16;
A23-B8-C22;
A23-B8-C28;
A23-B8-C34;
A23-B8-C40;
A23-B8-C46;
A24-B8-C6;
A24-B8-C12;
A24-B8-C18;
A24-B8-C24;
A24-B8-C30;
A24-B8-C36;
A24-B8-C42;
A25-B8-C2;
A25-B8-C8;
A25-B8-C14;
A25-B8-C20;
A25-B8-C26;
A25-B8-C32;
A25-B8-C38;
A25-B8-C44;
A26-B8-C4;
A26-B8-C10;
<td>A26-B8-C11;</td><td>A26-B8-C12;</td><td>A26-B8-C13;</td><td>A26-B8-C14;</td><td>A26-B8-C15;</td><td>A26-B8-C16;</td>
<td>A26-B8-C17;</td><td>A26-B8-C18;</td><td>A26-B8-C19;</td><td>A26-B8-C20;</td><td>A26-B8-C21;</td><td>A26-B8-C22;</td>
<td>A26-B8-C23;</td><td>A26-B8-C24;</td><td>A26-B8-C25;</td><td>A26-B8-C26;</td><td>A26-B8-C27;</td><td>A26-B8-C28;</td>
<td>A26-B8-C29;</td><td>A26-B8-C30;</td><td>A26-B8-C31;</td><td>A26-B8-C32;</td><td>A26-B8-C33;</td><td>A26-B8-C34;</td>
<td>A26-B8-C35;</td><td>A26-B8-C36;</td><td>A26-B8-C37;</td><td>A26-B8-C38;</td><td>A26-B8-C39;</td><td>A26-B8-C40;</td>
<td>A26-B8-C41;</td><td>A26-B8-C42;</td><td>A26-B8-C43;</td><td>A26-B8-C44;</td><td>A26-B8-C45;</td><td>A26-B8-C46;</td>
<td>A27-B8-C1;</td><td>A27-B8-C2;</td><td>A27-B8-C3;</td><td>A27-B8-C4;</td><td>A27-B8-C5;</td><td>A27-B8-C6;</td>
<td>A27-B8-C7;</td><td>A27-B8-C8;</td><td>A27-B8-C9;</td><td>A27-B8-C10;</td><td>A27-B8-C11;</td><td>A27-B8-C12;</td>
<td>A27-B8-C13;</td><td>A27-B8-C14;</td><td>A27-B8-C15;</td><td>A27-B8-C16;</td><td>A27-B8-C17;</td><td>A27-B8-C18;</td>
<td>A27-B8-C19;</td><td>A27-B8-C20;</td><td>A27-B8-C21;</td><td>A27-B8-C22;</td><td>A27-B8-C23;</td><td>A27-B8-C24;</td>
<td>A27-B8-C25;</td><td>A27-B8-C26;</td><td>A27-B8-C27;</td><td>A27-B8-C28;</td><td>A27-B8-C29;</td><td>A27-B8-C30;</td>
<td>A27-B8-C31;</td><td>A27-B8-C32;</td><td>A27-B8-C33;</td><td>A27-B8-C34;</td><td>A27-B8-C35;</td><td>A27-B8-C36;</td>
<td>A27-B8-C37;</td><td>A27-B8-C38;</td><td>A27-B8-C39;</td><td>A27-B8-C40;</td><td>A27-B8-C41;</td><td>A27-B8-C42;</td>
<td>A27-B8-C43;</td><td>A27-B8-C44;</td><td>A27-B8-C45;</td><td>A27-B8-C46;</td><td>A28-B8-C1;</td><td>A28-B8-C2;</td>
<td>A28-B8-C3;</td><td>A28-B8-C4;</td><td>A28-B8-C5;</td><td>A28-B8-C6;</td><td>A28-B8-C7;</td><td>A28-B8-C8;</td>
<td>A28-B8-C9;</td><td>A28-B8-C10;</td><td>A28-B8-C11;</td><td>A28-B8-C12;</td><td>A28-B8-C13;</td><td>A28-B8-C14;</td>
<td>A28-B8-C15;</td><td>A28-B8-C16;</td><td>A28-B8-C17;</td><td>A28-B8-C18;</td><td>A28-B8-C19;</td><td>A28-B8-C20;</td>
<td>A28-B8-C21;</td><td>A28-B8-C22;</td><td>A28-B8-C23;</td><td>A28-B8-C24;</td><td>A28-B8-C25;</td><td>A28-B8-C26;</td>
<td>A28-B8-C27;</td><td>A28-B8-C28;</td><td>A28-B8-C29;</td><td>A28-B8-C30;</td><td>A28-B8-C31;</td><td>A28-B8-C32;</td>
<td>A28-B8-C33;</td><td>A28-B8-C34;</td><td>A28-B8-C35;</td><td>A28-B8-C36;</td><td>A28-B8-C37;</td><td>A28-B8-C38;</td>
<td>A28-B8-C39;</td><td>A28-B8-C40;</td><td>A28-B8-C41;</td><td>A28-B8-C42;</td><td>A28-B8-C43;</td><td>A28-B8-C44;</td>
<td>A28-B8-C45;</td><td>A28-B8-C46;</td><td>A1-B9-C1;</td><td>A1-B9-C2;</td><td>A1-B9-C3;</td><td>A1-B9-C4;</td>
<td>A1-B9-C5;</td><td>A1-B9-C6;</td><td>A1-B9-C7; '</td><td>A1-B9-C8;</td><td>Al-B9-C9;</td><td>A1-B9-C10;</td>
<td>A1-B9-C11;</td><td>A1-B9-C12;</td><td>A1-B9-C13;</td><td>A1-B9-C14;</td><td>A1-B9-C15;</td><td>A1-B9-C16;</td>
<td>A1-B9-C17;</td><td>A1-B9-C18;</td><td>A1-B9-C19;</td><td>A1-B9-C20;</td><td>A1-B9-C21;</td><td>A1-B9-C22;</td>
<td>A1-B9-C23;</td><td>A1-B9-C24;</td><td>A1-B9-C25;</td><td>A1-B9-C26;</td><td>A1-B9-C27;</td><td>A1-B9-C28;</td>
<td>A1-B9-C29;</td><td>A1-B9-C30;</td><td>A1-B9-C31;</td><td>A1-B9-C32;</td><td>A1-B9-C33;</td><td>A1-B9-C34;</td>
<td>A1-B9-C35;</td><td>A1-B9-C36;</td><td>A1-B9-C37;</td><td>A1-B9-C38;</td><td>A1-B9-C39;</td><td>A1-B9-C40; '</td>
<td>A1-B9-C41;</td><td>A1-B9-C42;</td><td>A1-B9-C43;</td><td>A1-B9-C44;</td><td>A1-B9-C45;</td><td>A1-B9-C46;</td>
<td>A2-B9-C1;</td><td>A2-B9-C2;</td><td>A2-B9-C3;</td><td>A2-B9-C4;</td><td>A2-B9-C5;</td><td>A2-B9-C6;</td>
<td>A2-B9-C7;</td><td>A2-B9-C8;</td><td>A2-B9-C9;</td><td>A2-B9-C10;</td><td>A2-B9-C11;</td><td>A2-B9-C12;</td>
<td>A2-B9-C13;</td><td>A2-B9-C14;</td><td>A2-B9-C15;</td><td>A2-B9-C16;</td><td>A2-B9-C17;</td><td>A2-B9-C18;</td>
<td>A2-B9-C19;</td><td>A2-B9-C20;</td><td>A2-B9-C21;</td><td>A2-B9-C22;</td><td>A2-B9-C23;</td><td>A2-B9-C24;</td>
<td>A2-B9-C25;</td><td>A2-B9-C26;</td><td>A2-B9-C27;</td><td>A2-B9-C28;</td><td>A2-B9-C29;</td><td>A2-B9-C30;</td>
<td>A2-B9-C31;</td><td>A2-B9-C32;</td><td>A2-B9-C33;</td><td>A2-B9-C34;</td><td>A2-B9-C35;</td><td>A2-B9-C36;</td>
<td>A2-B9-C37;</td><td>A2-B9-C38;</td><td>A2-B9-C39;</td><td>A2-B9-C40;</td><td>A2-B9-C41;</td><td>A2-B9-C42;</td>
<td>A2-B9-C43;</td><td>A2-B9-C44;</td><td>A2-B9-C45;</td><td>A2-B9-C46;</td><td>A3-B9-C1;</td><td>A3-B9-C2;</td>
<td>A3-B9-C3;</td><td>A3-B9-C4;</td><td>A3-B9-C5;</td><td>A3-B9-C6;</td><td>A3-B9-C7;</td><td>A3-B9-C8;</td>
<td>A3-B9-C9;</td><td>A3-B9-C10;</td><td>A3-B9-C11;</td><td>A3-B9-C12;</td><td>A3-B9-C13;</td><td>A3-B9-C14;</td>
<td>A3-B9-C15;</td><td>A3-B9-C16;</td><td>A3-B9-C17;</td><td>A3-B9-C18;</td><td>A3-B9-C19;</td><td>A3-B9-C20;</td>
<td>A3-B9-C21;</td><td>A3-B9-C22;</td><td>A3-B9-C23;</td><td>A3-B9-C24;</td><td>A3-B9-C25;</td><td>A3-B9-C26;</td>
<td>A3-B9-C27;</td><td>A3-B9-C28;</td><td>A3-B9-C29;</td><td>A3-B9-C30;</td><td>A3-B9-C31;</td><td>A3-B9-C32;</td>
<td>A3-B9-C33;</td><td>A3-B9-C34;</td><td>A3-B9-C35;</td><td>A3-B9-C36;</td><td>A3-B9-C37;</td><td>A3-B9-C38;</td>
<td>A3-B9-C39;</td><td>A3-B9-C40;</td><td>A3-B9-C41;</td><td>A3-B9-C42;</td><td>A3-B9-C43;</td><td>A3-B9-C44;</td>
<td>A3-B9-C45;</td><td>A3-B9-C46;</td><td>A4-B9-C1;</td><td>A4-B9-C2;</td><td>A4-B9-C3;</td><td>A4-B9-C4;</td>
<td>A4-B9-C5;</td><td>A4-B9-C6;</td><td>A4-B9-C7;</td><td>A4-B9-C8;</td><td>A4-B9-C9;</td><td>A4-B9-C1D;</td>
<td>A4-B9-C11;</td><td>A4-B9-C12;</td><td>A4-B9-C13;</td><td>A4-B9-C14;</td><td>A4-B9-C15;</td><td>A4-B9-C16;</td>
<td>A4-B9-C17;</td><td>A4-B9-C18;</td><td>A4-B9-C19;</td><td>A4-B9-B20;</td><td>A4-B9-C21;</td><td>A4-B9-C22;</td>
<td>A4-B9-C23;</td><td>A4-B9-C24;</td><td>A4-B9-C25;</td><td>A4-B9-C26;</td><td>A4-B9-C27;</td><td>A4-B9-C28;</td>
<td>A4-B9-C29;</td><td>A4-B9-C30;</td><td>A4-B9-C31;</td><td>A4-B9-C32;</td><td>A4-B9-C33;</td><td>A4-39-C34;</td>
<td>A4-B9-C35;</td><td>A4-39-C36;</td><td>A4-B9-C37;</td><td>A4-B9-C38;</td><td>A4-B9-C39;</td><td>A4-B9-C40;</td>
<td>A4-B9-C41;</td><td>A4-B9-C42;</td><td>A4-B9-C43;</td><td>A4-B9-C44;</td><td>A4-B9-C45;</td><td>A4-B9-C46;</td>
<td>A5-B9-C1;</td><td>A5-B9-C2;</td><td>A5-B9-C3;</td><td>A5-B9-C4;</td><td>A5-B9-C5;</td><td>A5-B9-C6;</td>
<td>A5-B9-C7;</td><td>A5-B9-C8;</td><td>A5-B9-C9;</td><td>A5-B9-C10;</td><td>A5-B9-C11;</td><td>A5-B9-C12;</td>
<td>A5-B9-C13;</td><td>A5-B9-C14;</td><td>A5-B9-C15;</td><td>A5-B9-C16;</td><td>A5-B9-C17;</td><td>A5-B9-C18;</td>
<td>A5-B9-C19;</td><td>A5-B9-C20;</td><td>A5-B9-C21;</td><td>A5-B9-C22;</td><td>A5-B9-C23;</td><td>A5-B9-C24;</td>
<td>A5-B9-C25;</td><td>A5-B9-C26;</td><td>A5-B9-C27;</td><td>A5-B9-C28;</td><td>A5-B9-C29;</td><td>A5-B9-C30;</td>
<td>A5-B9-C31;</td><td>A5-B9-C32;</td><td>A5-B9-C33;</td><td>A5-B9-C34;</td><td>A5-B9-C35;</td><td>A5-B9-C36;</td>
<td>A5-B9-C37;</td><td>A5-B9-C38;</td><td>A5-B9-C39;</td><td>A5-B9-C40;</td><td>A5-B9-C41;</td><td>A5-B9-C42;</td>
<td>A5-B9-C43;</td><td>A5-B9-C44;</td><td>A5-B9-C45;</td><td>A5-B9-C46;</td><td>A6-B9-C1;</td><td>A6-39-C2;</td>
<td>A6-B9-C3;</td><td>A6-B9-C4;</td><td>A6-B9-C5;</td><td>A6-B9-C6;</td><td>A6-B9-C7;</td><td>A6-B9-C8;</td>
<td>A6-B9-C9;</td><td>A6-B9-C10;</td><td>A6-B9-C11;</td><td>A6-B9-C12;</td><td>A6-B9-C13;</td><td>A6-39-C14;</td>
<td>A6-B9-C15;</td><td>A6-B9-C16;</td><td>A6-B9-C17;</td><td>A6-B9-C18;</td><td>A6-B9-C19;</td><td>A6-B9-C20;</td>
<td>Α6-</td><td>B9-C21;</td><td>A6-B9-C22;</td><td>A6-B9-C23;</td><td>A6-B9-C24;</td><td>A6-B9-C25;</td><td>A6-B9-C26;</td>
<td>Α6-</td><td>B9-C27;</td><td>A6-B9-C28;</td><td>A6-B9-C29;</td><td>A6-B9-C30;</td><td>A6-B9-C31;</td><td>A6-B9-C32;</td>
<td>Α6-</td><td>B9-C33;</td><td>A6-B9-C34;</td><td>A6-B9-C35;</td><td>A6-B9-C36;</td><td>A6-B9-C37;</td><td>A6-B9-C38;</td>
<td>Α6-</td><td>B9-C39;</td><td>A6-B9-C40;</td><td>A6-B9-C41;</td><td>A6-B9-C42;</td><td>A6-B9-C43;</td><td>A6-B9-C44;</td>
<td>Α6-</td><td>B9-C45;</td><td>A6-B9-C46;</td><td>A7-B9-C1;</td><td>A7-B9-C2;</td><td>A7-B9-C3;</td><td>A7-B9-C4;</td>
<td>Α7-</td><td>B9-C5;</td><td>A7-B9-C6;</td><td>A7-B9-C7;</td><td>A7-B9-C8;</td><td>A7-B9-C9;</td><td>A7-B9-C10;</td>
<td>Α7-</td><td>39-C11;</td><td>A7-B9-C12;</td><td>A7-B9-C13;</td><td>A7-B9-C14;</td><td>A7-B9-C15;</td><td>A7-B9-C16;</td>
<td>Α7-</td><td>B9-C17;</td><td>A7-B9-C18;</td><td>A7-B9-C19;</td><td>A7-B9-C20;</td><td>A7-B9-C21;</td><td>A7-B9-C22;</td>
<td>Α7-</td><td>B9-C23;</td><td>A7-B9-C24;</td><td>A7-B9-C25;</td><td>A7-B9-C26;</td><td>A7-B9-C27;</td><td>A7-B9-C28;</td>
<td>Α7-</td><td>B9-C29;</td><td>A7-B9-C30;</td><td>A7-B9-C31;</td><td>A7-B9-C32;</td><td>A7-B9-C33;</td><td>A7-B9-C34;</td>
<td>Α7-</td><td>B9-C35;</td><td>A7-B9-C36;</td><td>A7-B9-C37;</td><td>A7-B9-C38;</td><td>A7-B9-C39;</td><td>A7-B9-C.40 ·;</td>
<td>Α7-</td><td>B9-C41;</td><td>A7-B9-C42;</td><td>A7-B9-C43;</td><td>A7-B9-C44;</td><td>A7-B9-C45;</td><td>A7-B9-C46;</td>
<td>Α8-</td><td>B9-C1;</td><td>A8-B9-C2;</td><td>A8-B9-C3;</td><td>A8-B9-C4;</td><td>A8-B9-C5;</td><td>A8-B9-C6;</td>
<td>Α8-</td><td>B9-C7;</td><td>A8-B9-C8;</td><td>A8-B9-C9;</td><td>A8-B9-C10;</td><td>A8-B9-C11;</td><td>A8-B9-C12;</td>
<td>Α8-</td><td>B9-C13;</td><td>A8-B9-C14;</td><td>A8-B9-C15;</td><td>A8-B9-C16;</td><td>A8-B9-C17;</td><td>A8-B9-C18;</td>
<td>Α8-</td><td>B9-C19;</td><td>A8-B9-C20;</td><td>A8-B9-C21;</td><td>A8-B9-C22;</td><td>A8-B9-C23;</td><td>A8-B9-C24;</td>
<td>Α8-</td><td>B9-C25;</td><td>A8-B9-C26;</td><td>A8-B9-C27;</td><td>A8-B9-C28;</td><td>A8-B9-C29;</td><td>A8-B9-C3o;</td>
<td>Α8-</td><td>B9-C31;</td><td>A8-B9-C32;</td><td>A8-B9-C33;</td><td>A8-B9-C34;</td><td>A8-B9-C35;</td><td>A8-B9-C36;</td>
<td>Α8-</td><td>B9-C37;</td><td>A8-B9-C38;</td><td>A8-B9-C39;</td><td>A8-B9-C40;</td><td>A8-B9-C41;</td><td>A8-B9-C42;</td>
<td>Α8-</td><td>B9-C43;</td><td>A8-B9-C44;</td><td>A8-B9-C45;</td><td>A8-B9-C46;</td><td>A9-B9-C1;</td><td>A9-B9-C2;</td>
<td>Α9-</td><td>B9-C3;</td><td>A9-B9-C4;</td><td>A9-B9-C5;</td><td>A9-B9-C6;</td><td>A9-B9-C7;</td><td>A9-B9-C8;</td>
<td>Α9-</td><td>39-C9;</td><td>A9-B9-C10;</td><td>A9-B9-C11;</td><td>A9-B9-C12;</td><td>A9-B9-C13;</td><td>A9-B9-C14;</td>
<td>Α9-</td><td>B9-C15;</td><td>A9-B9-C16;</td><td>A9-B9-C17;</td><td>A9-B9-C18;</td><td>A9-B9-C19;</td><td>A9-B9-C20;</td>
<td>Α9-</td><td>39-C21;</td><td>A9-B9-C22;</td><td>A9-B9-C23;</td><td>A9-B9-C24;</td><td>A9-B9-C25;</td><td>A9-B9-C26;</td>
<td>Α9-</td><td>B9-C27;</td><td>A9-B9-C28;</td><td>A9-B9-C29;</td><td>A9-B9-C30;</td><td>A9-B9-C31;</td><td>A9-B9-C32;</td>
<td>Α9-</td><td>B9-C33;</td><td>A9-B9-C34;</td><td>A9-B9-C35;</td><td>A9-B9-C36;</td><td>A9-B9-C37;</td><td>A9-B9-C38;</td>
<td>Α9-</td><td>B9-C39;</td><td>A9-B9-C40;</td><td>A9-B9-C41;</td><td>A9-B9-C42;</td><td>A9-B9-C43;</td><td>A9-B9-C44;</td>
<td>Α9-</td><td>B9-C45;</td><td>A9-B9-C46;</td><td>A10-B9-C1;</td><td>A10-B9-C2;</td><td>A10-B9-C3;</td><td>A1O-B9-C4;</td>
<td>Α10</td><td>-B9-C5;</td><td>A10-B9-C6;</td><td>A10-B9-C7;</td><td>A10-B9-C8;</td><td>A10-B9-C9;</td><td>A10-B9-C10;</td>
<td>A1O</td><td>-B9-C11;</td><td>A10-B9-C12;</td><td>A10-B9-C13;</td><td>A10-B9-C14;</td><td>A10-B9-C15;</td><td>A10-B9-C16;</td>
<td>A1O</td><td>-B9-C17;</td><td>A10-B9-C18;</td><td>A10-B9-C19;</td><td>A10-B9-C20;</td><td>A10-B9-C21;</td><td>A10-B9-C22;</td>
<td>A1O</td><td>-B9-C23;</td><td>A10-B9-C24;</td><td>A10-B9-C25;</td><td>A10-B9-C26;</td><td>A10-B9-C27;</td><td>A10-B9-C28;</td>
<td>A1O</td><td>-B9-C29;</td><td>A10-B9-C30;</td><td>A10-B9-C31;</td><td>A1O-B9-C32;</td><td>A10-B9-C33;</td><td>A10-B9-C34;</td>
<td>A1O</td><td>-B9-C35;</td><td>A1O-B9-C36;</td><td>A10-B9-C37;</td><td>A1O-B9-C38;</td><td>A10-B9-C39;</td><td>A1O-B9-C4O;</td>
<td>A1O</td><td>-B9-C41;</td><td>A10-B9-C42;</td><td>A10-B9-C43;</td><td>A1O-B9-C44;</td><td>A10-B9-C45;</td><td>A10-B9-C46;</td>
<td>All</td><td>-B9-C1;</td><td>A11-B9-C2;</td><td>A11-B9-C3;</td><td>A11-B9-C4;</td><td>A11-B9-C5;</td><td>A11-B9-C6;</td>
<td>All</td><td>-B9-C7;</td><td>A11-B9-C8;</td><td>A11-B9-C9;</td><td>A11-B9-C10;</td><td>A11-39-C11;</td><td>A11-B9-C12;</td>
<td>All</td><td>-B9-C13;</td><td>A11-B9-C14;</td><td>A11-B9-C15;</td><td>A11-B9-C16;</td><td>A11-B9-C17;</td><td>A11-B9-C18;</td>
<td>All</td><td>-39-C19;</td><td>A11-B9-C20;</td><td>A11-B9-C21;</td><td>A11-B9-C22;</td><td>A11-B9-C23;</td><td>A11-B9-C24;</td>
<td>All</td><td>-B9-C25;</td><td>A11-B9-C26;</td><td>A11-B9-C27;</td><td>A11-B9-C28;</td><td>A11-39-C29;</td><td>A11-39-C30;</td>
<td>All</td><td>-39-C31;</td><td>A11-B9-C32;</td><td>A11-B9-C33;</td><td>A11-B9-C34;</td><td>A11-B9-C35;</td><td>A11-B9-C36;</td>
<td>All</td><td>-B9-C37;</td><td>A11-B9-C38;</td><td>A11-B9-C39;</td><td>A11-B9-C40;</td><td>A11-B9-C41;</td><td>A11-B9-C42;</td>
<td>All</td><td>-39-C43;</td><td>A11-B9-C44;</td><td>A11-B9-C45;</td><td>A11-B9-C46;</td><td>A12-B9-C1;</td><td>A12-B9-C2;</td>
<td>A12</td><td>-B9-C3;</td><td>A12-B9-C4;</td><td>A12-B9-C5;</td><td>A12-B9-C6;</td><td>A12-B9-C7;</td><td>A12-B9-C8;</td>
<td>A12</td><td>-B9-C9;</td><td>A12-B9-C10;</td><td>A12-B9-C11;</td><td>A12-B9-C12;</td><td>A12-B9-C13;</td><td>A12-B9-C14;</td>
<td>A12</td><td>-B9-C15;</td><td>A12-B9-C16;</td><td>A12-B9-C17;</td><td>A12-B9-C18;</td><td>A12-B9-C19;</td><td>A12-B9-C20;</td>
<td>A12</td><td>-B9-C21;</td><td>A12-B9-C22;</td><td>A12-B9-C23;</td><td>A12-B9-C24;</td><td>A12-B9-C25;</td><td>A12-B9-C26;</td>
<td>A12</td><td>-B9-C27;</td><td>A12-B9-C28 ·;</td><td>A12-B9-C29;</td><td>A12-B9-C30;</td><td>A12-B9-C31;</td><td>A12-B9-C32;</td>
<td>A12</td><td>-B9-C33;</td><td>A12-B9-C34;</td><td>A12-B9-C35;</td><td>A12-B9-C36;</td><td>A12-B9-C37;</td><td>A12-B9-C38;</td>
<td>A12</td><td>-B9-C39;</td><td>A12-B9-C40;</td><td>A12-B9-C41;</td><td>A12-B9 C42;</td><td>A12-B9-C43;</td><td>A12-B9-C44;</td>
<td>A12</td><td>-B9-C45;</td><td>A12-B9-C46;</td><td>A13-B9-C1;</td><td>A13-B9-C2;</td><td>A13-B9-C3;</td><td>A13-B9-C4;</td>
<td>A13</td><td>-B9-C5;</td><td>A13-B9-C6;</td><td>A13-B9-C7;</td><td>A13-B9-C8;</td><td>A13-B9-C9;</td><td>A13-B9-C10;</td>
<td>A13</td><td>-B9-C11;</td><td>A13-B9-C12;</td><td>A13-B9-C13;</td><td>A13-B9-C14;</td><td>A13-B9-C15;</td><td>A13-39-C16;</td>
<td>A13</td><td>-B9-C17;</td><td>A13-B9-C18;</td><td>A13-B9-C19;</td><td>A13-B9-C20;</td><td>A13-B9-C21;</td><td>A13-B9-C22;</td>
<td>A13</td><td>-B9-C23;</td><td>A13-B9-C24;</td><td>A13-B9-C25;</td><td>A13-B9-C26;</td><td>A13-B9-C27;</td><td>A13-B9-C28;</td>
<td>A13</td><td>-39-C29;</td><td>A13-B9-C30;</td><td>A13-B9-C31;</td><td>A13-B9-C32;</td><td>A13-B9-C33;</td><td>A13-B9-C34;</td>
<td>A13</td><td>-B9-C35;</td><td>A13-B9-C36;</td><td>A13-B9-C37;</td><td>A13-B9-C38;</td><td>A13-B9-C39;</td><td>A13-B9-C40;</td>
<td>A13</td><td>-39-C41;</td><td>A13-B9-C42;</td><td>A13-B9-C43;</td><td>A13-B9-C44;</td><td>A13-B9-C45;</td><td>A13-B9-C46;</td>
<td>A14</td><td>-B9-C1;</td><td>A14-B9-C2;</td><td>A14-B9-C3;</td><td>A14-B9-C4;</td><td>A14-B9-C5;</td><td>A14-B9-C6;</td>
<td>A14</td><td>-B9-C7;</td><td>A14-B9-C8;</td><td>A14-B9-C9;</td><td>A14-B9-C10;</td><td>A14-B9-C11;</td><td>A14-B9-C12;</td>
<td>A14</td><td>-B9-C13;</td><td>A14-B9-C14;</td><td>A14-B9-C15;</td><td>A14-B9-C16;</td><td>A14-B9-C17;</td><td>A14-B9-C18;</td>
<td>A14</td><td>-B9-C19;</td><td>A14-B9-C20;</td><td>A14-B9-C21;</td><td>A14-B9-C22;</td><td>A14-B9-C23;</td><td>A14-B9-C24;</td>
<td>A14</td><td>-B9-C25;</td><td>A14-B9-C26;</td><td>A14-B9-C27;</td><td>A14-B9-C28;</td><td>A14-B9-C29;</td><td>A14-B9-C3o;</td>
A14-B9-C31;
A14-B9-C37;
A14-B9-C43;
A15-B9-C3;
A15-B9-C9;
A15-B9-C15;
A15-B9-C21;
A15-B9-C27;
A15-B9-C33;
A15-B9-C39;
A15-B9-C45;
A16-B9-C5;
A16-B9-C11;
A16-B9-C17;
A16-B9-C23;
A16-B9-C29;
A16-B9-C35;
A16-B9-C41;
A17-B9-C1;
A17-B9-C7;
A17-B9-C13;
A17-B9-C19;
A17-B9-C25;
A17-B9-C31;
A17-B9-C37;
A17-B9-C43;
A18-B9-C3;
A18-B9-C9;
A18-B9-C15;
A18-B9-C21;
A18-B9-C27;
A18-B9-C33;
A18-B9-C39;
A18-B9-C45;
A19-B9-C5;
A19-B9-C11;
A19-B9-C17;
A19-B9-C23;
A19-B9-C29;
A19-B9-C35;
A19-B9-C41;
A20-B9-C1;
A20-B9-C7;
A20-B9-C13;
A20-B9-C19;
A20-B9-C25;
A20-B9-C31;
A20-B9-C37;
A20-B9-C43;
A21-B9-C3;
A21-B9-C9;
A21-B9-C15;
A21-B9-C21;
A21-B9-C27;
A21-B9-C33;
A21-B9-C39;
A21-B9-C45; A22-B9-C5;
A22-B9-C11;
A22-B9-C17;
A22-B9-C23;
A22-B9-C29;
A22-B9-C35;
A14-B9-C32; A14-B9-C38; A14-B9-C44; A15-B9-C4;
A15-B9-C10;
A15-B9-C16;
A15-B9-C22;
A15-B9-C28;
A15-B9-C34;
A15-B9-C40;
A15-B9-C46; B9-A16-C6;
A16-B9-C12; A16-B9-C18; A16-B9-C24;
A16-B9-C30;
A16-B9-C36;
A16-B9-C42; A17-B9-C2;
A17-B9-C8;
A17-B9-C14;
A17-B9-C20;
A17-B9-C26;
A17-B9-C32;
A17-B9-C38;
A17-B9-C44; A18-B9-C4;
A18-B9-C10;
A18-B9-C16;
A18-B9-C22;
A18-B9-C28;
A18-B9-C34;
A18-B9-C40;
A18-B9-C46; A19-B9-C6;
A19-B9-C12;
A19-B9-C18;
A19-B9-C24;
A19-B9-C30;
A19-B9-C36;
A19-B9-C42;
A20-B9-C2;
A20-B9-C8;
A20-B9-C14;
A20-B9-C20;
A20-B9-C26;
A20-B9-C32;
A20-B9-C38; A20-B9-C44; A21-B9-C4;
A21-B9-C10;
A21-B9-C16;
A21-B9-C22;
A21-B9-C28; A21-B9-C34; A21-B9-C40;
A21-B9-C46; A22-B9-C6;
A22-B9-C12;
A22-B9-C18;
A22-B9-C24;
A22-B9-C30;
A22-B9-C36;
A14-B9-C33;
A14-B9-C39;
A14-B9-C45;
A15-B9-C5;
A15-B9-C11;
A15-B9-C17;
A15-B9-C23;
A15-B9-C29;
A15-B9-C35;
A15-B9-C41;
A16-B9-C1;
A16-B9-C7;
A16-B9-C13;
A16-B9-C19;
A16-B9-C25;
A16-B9-C31;
A16-B9-C37;
A16-B9-C43;
A17-B9-C3;
A17-B9-C9;
A17-B9-C15;
A17-B9-C21;
A17-B9-C27;
A17-B9-C33;
A17-B9-C39;
A17-B9-C45; A18-B9-C5;
A18-B9-C11;
A18-B9-C17;
A18-B9-C23;
A18-B9-C29;
A18-B9-C35;
A18-B9-C41;
A19-B9-C1;
A19-B9-C7;
A19-B9-C13;
A19-B9-C19;
A19-B9-C25;
A19-B9-C31;
A19-B9-C37;
A19-B9-C43;
A20-39-C3;
A20-29-C9;
A20-39-C15;
A20-39-C21;
A20-39-C27;
A20-B9-C33;
A20-B9-C39;
A20-B9-C45; A21-B9-C5;
A21-B9-C11;
A21-B9-C17;
A21-S9-C23;
A21-39-C29;
A21-39-C35;
A21-B9-C41;
A22-B9-C1;
A22-39-C7;
A22-B9-C13;
A22-39-C19;
A22-B9-C25;
A22-B9-C31;
A22-B9-C37;
A14-B9-C34;
A14-B9-C40;
A14-B9 C46; A15-B9-C6;
A15-B9-C12;
A15-B9-C18;
A15-B9-C24;
A15-B9-C30;
A15-B9-C36;
A15-B9-C42;
A16-B9-C2;
A16-B9-C8;
A16-B9-C14;
A16-B9-C20;
A16-B9-C26;
A16-B9-C32;
A16-B9-C38;
A16-B9-C44; A17-B9-C4;
A17-B9-C10;
A17-B9-C16;
A17 B9-C22;
A17-B9-C28;
A17-B9-C34;
A17-B9-C40;
A17-B9-C46;
A18-B9-C6;
A18-B9-C12;
A18-B9-C18;
A18-B9-C24;
A18-B9-C30;
A18-B9-C36;
A18-B9-C42;
A19-B9-C2;
A19-B9-C8;
A19-B9-C14;
A19-B9-C20;
A19-B9-C26;
A19-B9-C32;
A19-B9-C38;
A19-B9-C44; A20-B9-C4;
A20-B9-C10;
A20-B9-C16;
A20-B9-C22;
A20-39-C28;
A20-B9-C34;
A20-B9-C40;
A20-B9-C46;
A21-B9-C6;
A21-B9-C12;
A21-B9-C18;
A21-B9-C24;
A21-B9-C30;
A21-B9-C36;
A21-B9-C42;
A22-B9-C2;
A22-B9-C8;
A22-B9-C14;
A22-B9-B20;
A22-B9-C26;
A22-B9-C32;
A22-B9-C38;
A14-B9-C35;
A14-B9-C41;
A15-B9-C1;
A15-B9-C7;
A15-B9-C13;
A15-B9-C19;
A15-B9-C25;
A15-B9-C31;
A15-B9-C37;
A15-B9-C43;
A16-B9-C3;
A16-B9-C9;
A16-B9-C15;
A16-B9-C21;
A16-B9-C27;
A16-B9-C33;
A16-B9-C39;
A16-B9-C45; A17-B9-C5;
A17-B9-C11;
A17-B9-C17;
A17-B9-C23;
A17-B9-C29;
A17-B9-C35;
A17-B9-C41;
A18-B9-C1;
A18-B9-C7;
A18-B9-C13;
A18-B9-C19;
A18-B9-C25;
A18-B9-C31;
A18-B9-C37;
A18-B9-C43;
A19-B9-C3;
A19-B9-C9;
A19-B9-C15;
A19-B9-C21;
A19-B9-C27;
A19-B9-C33;
A19-B9-C39;
A19-B9-C45;
A20-B9-C5;
A20-B9-C11;
A20-B9-C17;
A20-B9-C23;
A20-B9-C29;
A20-B9-C35;
A20-B9-C41;
A21-B9-C1;
A21-B9-C7;
A21-B9-C13;
A21-B9-C19;
A21-B9-C25;
A21-B9-C31;
A21-B9-C37;
A21-B9-C43;
A22-B9-C3;
A22-B9-C9;
A22-B9-C15;
A22-B9-C21;
A22-B9-C27;
A22-B9-C33;
A22-B9-C39;
A14-B9-C36;
A14-B9-C42;
A15-B9-C2;
A15-B9-C8;
A15-B9-C14;
A15-B9-C20;
A15-B9-C26;
A15-B9-C32;
A15-B9-C38;
A15-B9-C44;
A16-B9-C4;
A16-B9-C10;
A16-B9-C16;
A16-B9-C22;
A16-B9-C28; A16-B9-C34;
A16-B9-C40;
A16-B9-C46; A17-B9-C6;
A17-B9-C12;
A17-B9-C18;
A17-B9-C24;
A17-B9-C30;
Ä17-59 -C 36;
A17-B9-C42;
A18-B9-C2;
A18-B9-C8;
A18-B9-C14;
A18-B9-C20;
A18-B9-C26;
A18-E9-C32;
A18-39-C38; A18-39-C44;
19-E9-C4;
A19-B9-C10;
A19-E9-C16;
A19-E9-C22;
A19-E9-C28;
A19-B9-C34;
A19-B9-C40;
A19-B9-C46;
A20-B9-C6;
A20-E9-C12;
A20-B9-C18;
A20-B9-C24;
A20-E9-C30;
A20-B9-C36;
A20-B9-C42;
A21-E9-C2;
A21-E9-C8;
A21-B9-C14;
A21-E9-C20;
A21-B9-C26;
A21-E9-C32;
A21-B9-C38;
A21-E9-C44;
A22-B9-C4;
A22-B9-C10;
A22-B9-C16;
A22-B9-C22;
A22-B9-C28;
A22-B9-C34;
A22-B9-C40;
A22-B9-C41;
A23-B9-C1;
A23-B9-C7;
A23-B9-C13;
A23-B9-C19;
A23-B9-C25;
A23-B9-C31;
A23-B9-C37;
A23-B9-C43;
A24-B9-C3;
A24-B9-C9;
A24-B9-C15;
A24-B9-C21;
A24-B9-C27;
A24-B9-C33;
A24-B9-C39;
A24-B9-C45; A25-B9-C5;
A25-B9-C11;
A25-B9-C17;
A25-B9-C23;
A25-B9-C29;
A25-B9-C35;
A25-B9-C41;
A26-B9-C1;
A26-B9-C7;
A26-B9-C13;
A26-B9-C19;
A26-B9-C25;
A26-B9-C31;
A26-B9-C37;
A26-B9-C43;
A27-B9-C3;
A27-B9-C9;
A27-B9-C15;
A27-B9-C21;
A27-B9-C27;
A27-B9-C33;
A27-B9-C39;
A27-B9-C45; A28-B9-C5;
A28-B9-C11;
A28-B9-C17;
A28-B9-C23;
A28-B9-C29;
A28-B9-C35;
A28-B9-C41;
A1-B10-C1;
A1-B10-C7;
A1-B10-C13;
A1-B10-C19;
A1-B10-C25;
A1-B10-C31;
A1-B10-C37;
A1-B10-C43;
A2-B10-C3;
A2-B10-C9;
A2-B10-C15;
A2-B10-C21;
A2-B10-C27;
A2-B10-C33;
A2-B10-C39;
A2-B10-C45;
A22-B9-C42;
A23-B9-C2;
A23-B9-C8;
A23-B9-C14;
A23-B9-C20;
A23-B9-C26;
A23-B9-C32;
A23-B9-C38;
A23-B9-C44;
A24-B9-C4;
A24-B9-C10;
A24-B9-C16;
A24-B9-C22;
A24-B9-C28;
A24-B9-C34;
A24-B9-C40;
A24-B9-C46;
A25-B9-C6;
A25-B9-C12;
A25-B9-C18;
A25-B9-C24;
A25-B9-C30;
A25-B9-C36;
A25-B9-C42;
A26-B9-C2;
A26-B9-C8;
A26-B9-C14;
A26-B9-C20;
A26-B9-C26;
A26-B9-C32;
A26-B9-C38;
A26-B9-C44;
A27-B9-C4;
A27-B9-C10;
A27-B9-C16;
A27-B9-C22;
A27-B9-C28;
A27-B9-C34;
A27-B9-C40;
A27-B9-C46;
A28-B9-C6;
A28-B9-C12;
A28-B9-C18;
A28-B9-C24;
A28-B9-C30;
A28-B9-C36;
A28-B9-C42;
A1-B10-C2; ·
A1-B10-C8;
A1-B10-C14;
A1-B10-C20;
A1-B10-C26;
A1-310-C32;
A1-B10-C38;
A1-B10-C44;
A2-B10-C4;
A2-B10-C10;
A2-B10-C16;
A2-B10-C22;
A2-B10-C28;
A2-B10-C34;
A2-B10-C40;
A2-B10-C46;
A22-B9-C43;
A23-B9-C3;
A23-B9-C9;
A23-B9-C15;
A23-B9-C21;
A23-B9-C27;
A23-B9-C33;
A23-B9-C39;
A23-B9-C45;
A24-B9-C5;
A24-B9-C11;
A24-B9-C17;
A24-B9-C23;
A24-B9-C29;
A24-B9-C35;
A24-B9-C41;
A25-39-C1;
A25-B9-C7;
A25-B9-C13;
A25-B9-C19;
A25-B9-C25;
A25-B9-C31;
A25-B9-C37;
A25-B9-C43;
A26-B9-C3;
A26-B9-C9;
A26-39-C15;
A26-B9-C21;
A26-B9-C27;
A26-B9-C33;
A26-B9-C39;
A26-B9-C45; A27-B9-C5;
A27-B9-C11;
A27-B9-C17;
A27-B9-C23;
A27-B9-C29;
A27-B9-C35;
A27-B9-C41;
A28-B9-C1;
A28-B9-C7;
A28-B9-C13;
A28-39-C19;
A28-B9-C25;
A28-39-C31;
A28-B9-C37;
A28-39-C43;
A1-B10-C3;
A1-B10-C9;
A1-B10-C15;
A1-310-C21;
A1-B10-C27;
A1-B10-C33;
A1-B10-C39;
A1-B10-C45; A2-B10-C5;
A2-B10-C11;
A2-B10-C17;
A2-B10-C23;
A2-310 -C 29;
A2-B10-C35;
A2-B10-C41;
A3-B10-C1;
A22-B9-C44; A23-B9-C4;
A23-B9-C10;
A23-B9-C16;
A23-B9-C22;
A23-B9-C28;
A23-B9-C34;
A23-B9-C40;
A23-B9-C46;
A24-B9-C6;
A24-B9-C12;
A24-B9-C18;
A24-B9-C24;
A24-B9-C30;
A24-B9-C36;
A24-B9-C42;
A25-B9-C2;
A25-B9-C8;
A25-B9-C14;
A25-B9-C20;
A25-B9-C26;
A25-B9-C32;
A25-B9-C38;
A25-B9-C44;
A26-B9-C4;
A26-B9-C10;
A26-B9-C16;
A26-B9-C22;
A26-B9-C28;
A26-B9-C34;
A26-B9-C40;
A26-B9-C46;
A27-B9-C6;
A27-B9-C12;
A27-B9-C18;
A27-B9-C24;
A27-B9-C30;
A27-B9-C36;
A27-B9-C42;
A28-B9-C2;
A28-B9-C8;
A28-B9-C14;
A28-B9-C20;
A28-B9-C26;
A28-B9-C32;
A28-B9-C38;
A28-B9-C44;
A1-B10-C4;
A1-B10-C10;
A1-B10-C16;
A1-310-C22;
A1-B10-C28;
A1-B10-C34;
A1-B10-C40;
A1-B10-C46;
A2-310-C6;
A2-B10-C12;
A2-B10-C18;
A2-B10-C24;
A2-B10-C30;
A2-310 -C 36;
A2-B10-C42;
A3-B10-C2;
A22-B9-C45;
A23-B9-C5;
A23-B9-C11;
A23-B9-C17;
A23-B9-C23;
A23-B9-C29;
A23-B9-C35;
A23-B9-C41;
A24-B9-C1;
A24-B9-C7;
A24-B9-C13;
A24-B9-C19;
A24-B9-C25;
A24-B9-C31;
A24-B9-C37;
A24-B9-C43;
A25-B9-C3;
A25-B9-C9;
A25-B9-C15;
A25-B9-C21;
A25-B9-C27;
A25-B9-C33;
A25-B9-C39;
A25-B9-C45;
A26-B9-C5;
A26-B9-C11;
A26-B9-C17;
A26-B9-C23;
A26-B9-C29;
A26-B9-C35;
A26-B9-C41;
A27-B9-C1;
A27-B9-C7;
A27-B9-C13;
A27-B9-C19;
A27-B9-C25;
A27-B9-C31;
A27-B9-C37;
A27-B9-C43;
A28-B9-C3;
A28-B9-C9;
A28-B9-C15;
A28-B9-C21;
A28-B9-C27;
A28-B9-C33;
A28-B9-C39;
A28-B9-C45;
A1-B10-C5;
A1-B10-C11;
A1-B10-C17;
A1-B10-C23;
A1-B10-C29;
A1-B10-C35;
A1-B10-C41;
A2-B10-C1;
A2-B10-C7;
A2-B10-C13;
A2-B10-C19;
A2-B10-C25;
A2-B10-C31;
A2-B10-C37;
A2-B10-C43;
A3-B10-C3;
A22-B9-C46;
A23-B9-C6;
A23-B9-C12;
A23-B9-C18;
A23-B9-C24;
A23-B9-C30;
A23-B9-C36;
A23-B9-C42;
A24-B9-C2;
A24-B9-C8; .
A24-B9-C14; '
A24-B9-C20;
A24-B9-C26;
A24-B9-C32;
A24-B9-C38;
A24-B9-C44;
A25-B9-C4;
A25-B9-C10;
A25-B9-C16;
A25-B9-C22;
A25-B9-C28;
A25-B9-C34;
A25-B9-C40;
A25-B9-C46; A26-B9-C6;
A26-B9-C12;
A26-B9-C18;
A26-B9-C24;
A26-39-C30;
A26-B9-C36;
A26-B9-C42;
A27-B9-C2;
A27-B9-C8;
A27-B9-C14;
A27-B9-C20;
A27-B9-C26;
A27-B9-C32;
A2<sup>?</sup>-B9-C38;
A27-B9-C44;
A28-B9-C4;
A28-B9-C10;
A28-B9-C16;
A28-B9-C22;
A28-B9-C28;
A28-B9-C34;
A28-B9-C40;
A28-B9-C46;
A1-B10-C6;
A1-B10-C12;
A1-B10-C18;
A1-B10-C24;
A1-B10-C30;
A1-B10-C36;
A1-B10-C42;
A 2-B1O-C2;
A2-B10-C8;
A2-B10-C14;
A2-B10-C20;
A 2-B1O-C26;
A2-B10-C32;
A2-B10-C38;
A2-B10-C44;
A3-B10-C4;
<td>A3-B10-C5;</td><td>A3-B10-C6;</td><td>A3-B10-C7;</td><td>A3-B10-C8;</td><td>A3-B10-C9;</td><td>A3-B10-C10;</td>
<td>A3-B10-C11;</td><td>A3-B10-C12;</td><td>A3-B10-C13;</td><td>A3-B10-C14;</td><td>A3-B1O-C15;</td><td>A3-B10-C16;</td>
<td>A3-B10-C17;</td><td>A3-B10-C18;</td><td>A3-B1O-C19;</td><td>A3-B10-C20;</td><td>A3-B10-C21;</td><td>A3-B10-C22;</td>
<td>A3-B10-C23;</td><td>A3-B1O-C24;</td><td>A3-B10-C25;</td><td>A3-B10-C26;</td><td>A3-B10-C27;</td><td>A3-B10-C28;</td>
<td>A3-B10-C29;</td><td>A3-B10-C30;</td><td>A3-B10-C31;</td><td>A3-B10-C32;</td><td>A3-B10-C33;</td><td>A3-B10-C34;</td>
<td>A3-B10-C35;</td><td>A3-B10-C36;</td><td>A3-B10-C37;</td><td>A3-B10-C38;</td><td>A3-B10-C39;</td><td>A3-B10-C40;</td>
<td>A3-B1O-C41;</td><td>A3-B10-C42;</td><td>A3-B1O-C43;</td><td>A3-B1O-C44;</td><td>A3-B1O-C45;</td><td>A3-B10-C46;</td>
<td>A4-B10-C1;</td><td>A4-B10-C2;</td><td>A4-B1O-C3;</td><td>A4-B1O-C4;</td><td>A4-B10-C5;</td><td>A4-B1O-C6;</td>
<td>A4-B10-C7;</td><td>A4-B10-C8;</td><td>A4-B10-C9;</td><td>A4-B10-C10;</td><td>A4-B1O-C11;</td><td>A4-B10-C12;</td>
<td>A4-B10-C13;</td><td>A4-B10-C14;</td><td>A4-B10-C15;</td><td>A4-B1O-C16;</td><td>A4-B10-C17;</td><td>A4-B10-C18;</td>
<td>A4-B10-C19;</td><td>A4-B10-C20;</td><td>A4-B10-C21;</td><td>A4-B10-C22;</td><td>A4-B1O-C23;</td><td>A4-B10-C24;</td>
<td>A4-B10-C25;</td><td>A4-B10-C26;</td><td>A4-B10-C27;</td><td>A4-B1O-C28;</td><td>A4-B10-C29;</td><td>A4-B10-C30;</td>
<td>A4-B10-C31;</td><td>A4-B10-C32;</td><td>A4-B10-C33;</td><td>A4-B1O-C34;</td><td>A4-B10-C35;</td><td>A4-B1O-C36;</td>
<td>A4-B10-C37;</td><td>A4-B10-C38;</td><td>A4-B1O-C39;</td><td>A4-B10-C40;</td><td>A4-B10-C41;</td><td>A4-B10-C42;</td>
<td>A4-B10-C43;</td><td>A4-B10-C44;</td><td>A4-B10-C45;</td><td>A4-B1O-C46;</td><td>A5-B10-C1;</td><td>A5-B10-C2;</td>
<td>A5-B10-C3;</td><td>A5-B10-C4;</td><td>A5-B10-C5;</td><td>A5-B10-C6;</td><td>A5-B10-C7;</td><td>A5-B10-C8;</td>
<td>A5-B10-C9;</td><td>A5-B10-C10;</td><td>A5-B10-C11;</td><td>A5-B10-C12;</td><td>A5-B10-C13;</td><td>A5-B10-C14;</td>
<td>A5-B10-C15;</td><td>A5-B1O-C16;</td><td>A5-B10-C17;</td><td>A5-B10-C18;</td><td>A5-B10-C19;</td><td>A5-B10-C20;</td>
<td>A5-B10-C21;</td><td>A5-B10-C22;</td><td>A5-B10-C23;</td><td>A5-B10-C24;</td><td>A5-B10-C25;</td><td>A5-B1O-C26;</td>
<td>A5-B10-C27;</td><td>A5-B10-C28;</td><td>A5-B10-C29;</td><td>A5-B10-C30;</td><td>A5-B10-C31;</td><td>A5-310-C32;</td>
<td>A5-B10-C33;</td><td>A5-B1O-C34;</td><td>A5-B10-C35;</td><td>A5-B10-C36;</td><td>A5-B10-C37;</td><td>A5-3ÍO-C38;</td>
<td>A5-B10-C39;</td><td>A5-B10-C40;</td><td>A5-B1O-C41;</td><td>A5-B10-C42;</td><td>A5-B10-C43;</td><td>A5-310-C44;</td>
<td>A5-B10-C45;</td><td>A5-B1O-C46;</td><td>A6-B10-C1;</td><td>A6-B10-C2;</td><td>A6-B10-C3;</td><td>A6-310-C4;</td>
<td>A6-B10-C5;</td><td>A6-B10-C6;</td><td>A6-B10-C7;</td><td>A6-B10-C8;</td><td>A6-B10-C9;</td><td>A6-B10-C10;</td>
<td>A6-B10-C11;</td><td>A6-B1O-C12;</td><td>A6-B10-C13;</td><td>A6-B1O-C14;</td><td>A6-B10-C15;</td><td>A6-B10-C16;</td>
<td>A6-B10-C17;</td><td>A6-B10-C18;</td><td>A6-B10-C19;</td><td>A6-B10-C20;</td><td>A6-B10-C21;</td><td>A6-310-C22;</td>
<td>A6-B10-C23;</td><td>A6-B10-C24;</td><td>A6-B10-C25;</td><td>A6-B10-C26;</td><td>A6-B10-C27;</td><td>A6-B10-C28;</td>
<td>Α6-Β1'-C29;</td><td>A6-B10-C30;</td><td>A6-B10-C31;</td><td>A6-B10-C32;</td><td>A6-B10-C33;</td><td>A6-E10-C34;</td>
<td>A6-B1Ú7C35;</td><td>A6-B10-C36;</td><td>A6-B10-C37;</td><td>A6-B10-C38;</td><td>A6-B10-C39;</td><td>A6-310-C40;</td>
<td>A6-B10-C41;</td><td>A6-B10-C42;</td><td>A6-BÍ0-C43;</td><td>A6-B10-C44;</td><td>A6-B10-C45;</td><td>A6-310-C46;</td>
<td>A7-B10-C1;</td><td>A7-B10-C2;</td><td>A7-B10-C3;</td><td>A7-B1O-C4;</td><td>A7-B10-C5;</td><td>A7-310-C6;</td>
<td>A7-B10-C7;</td><td>A7-B10-C8;</td><td>A7-B10-C9;</td><td>A7-B10-C10;</td><td>A7-B10-C11;</td><td>A7-310-C12;</td>
<td>A7-B10-C13;</td><td>A7-B10-C14;</td><td>A7-B10-C15;</td><td>A7-B10-C16;</td><td>A7-B10-C17;</td><td>A7-310-C18;</td>
<td>A7-B10-C19;</td><td>A7-B10-C20;</td><td>A7-B10-C21;</td><td>A7-B10-C22;</td><td>A7-B10-C23;</td><td>A7-310-C24;</td>
<td>A7-B10-C25;</td><td>A7-B10-C26;</td><td>A7-B10-C27;</td><td>A7-B10-C28;</td><td>A7-B10-C29;</td><td>A7-B10-C30;</td>
<td>A7-B10-C31;</td><td>A7-B10-C32;</td><td>A7-B10-C33;</td><td>A7-B10-C34;</td><td>A7-B10-C35;</td><td>A7-B10-C36;</td>
<td>A7-B10-C37;</td><td>A7-B10-C38;</td><td>A7-B10-C39;</td><td>A7-B1O-C4O;</td><td>A7-B10-C41;</td><td>A7-B10-C42;</td>
<td>A7-B10-C43;</td><td>A7-B10-C44;</td><td>A7-B1O-C45;</td><td>A7-B10-C46;</td><td>A8-B10-C1;</td><td>A8-B10-C2;</td>
<td>A8-B10-C3;</td><td>A8-B10-C4;</td><td>A8-B1O-C5;</td><td>A8-B10-C6;</td><td>A8-B10-C7;</td><td>A8-B10-C8;</td>
<td>A8-B10-C9;</td><td>A8-B10-C10;</td><td>A8-B10-C11;</td><td>A8-B10-C12;</td><td>A8-B10-C13;</td><td>A8-BÍ0-C14;</td>
<td>A8-B10-C15;</td><td>A8-B10-C16;</td><td>A8-B10-C17;</td><td>A8-B1O-C18;</td><td>A8-B10-C19;</td><td>A8-B10-C20;</td>
<td>A8-B10-C21;</td><td>A8-B10-C22;</td><td>A8-B10-C23;</td><td>A8-B10-C24;</td><td>A8-B10-C25;</td><td>A8-B10-C26;</td>
<td>A8-B10-C27;</td><td>A8-B1O-C28;</td><td>A8-B10-C29;</td><td>A8-B1O-C3O;</td><td>A8-B10-C31;</td><td>A8-310-C32;</td>
<td>A8-B10-C33;</td><td>A8-B1O-C34;</td><td>A8-B10-C35;</td><td>A8-B10-C36;</td><td>A8-B10-C37;</td><td>A8-310-C38;</td>
<td>A8-B10-C39;</td><td>A8-B10-C40;</td><td>A8-B10-C41;</td><td>A8-B10-C42;</td><td>A8-B10-C43;</td><td>A8-310-C44;</td>
<td>A8-B10-C45;</td><td>A8-B1O-C46;</td><td>A9-B10-C1;</td><td>A9-B10-C2;</td><td>A9-B10-C3;</td><td>A9-310-C4;</td>
<td>A9-B10-C5;</td><td>A9-B10-C6;</td><td>A9-B10-C7;</td><td>A9-B10-C8;</td><td>A9-B10-C9;</td><td>A9-310-C10;</td>
<td>A9-B10-C11;</td><td>A9-B1O-C12;</td><td>A9-B10-C13;</td><td>A9-B1O-C14;</td><td>A9-B10-C15;</td><td>A9-B10-C16;</td>
<td>A9-B10-C17;</td><td>A9-B1O-C18;</td><td>A9-B10-C19;</td><td>A9-B10-C20;</td><td>A9-B10-C21;</td><td>A9-310-C22;</td>
<td>A9-B10-C23;</td><td>A9-B10-C24;</td><td>A9-B1O-C25;</td><td>A9-B10-C26;</td><td>A9-B10-C27;</td><td>A9-310-C28;</td>
<td>A9-B10-C29;</td><td>A9-B10-C30;</td><td>A9-B10-C31;</td><td>A9-B10-C32;</td><td>A9-B10-C33;</td><td>A9-310-C34;</td>
<td>A9-B10-C35;</td><td>A9-B10-C36;</td><td>A9-B1O-C37;</td><td>A9-B10-C38;</td><td>A9-B10-C39;</td><td>A9-B10-C40;</td>
<td>A9-B10-C41;</td><td>A9-B10-C42;</td><td>A9-310-C43;</td><td>A9-B10-C44;</td><td>A9-B10-C45;</td><td>A9-B10-C46;</td>
<td>A10-B10-C1;</td><td>A10-B10-C2;</td><td>A10-B10-C3;</td><td>A10-B10-C4;</td><td>A10-B10-C5;</td><td>A10-B10-C6;</td>
<td>A10-B10-C7;</td><td>A10-B10-C8;</td><td>A10-B10-C9;</td><td>A10-B10-</td><td>A10-B10-</td><td>Α1Ο-Ξ1Ο-</td>
<td></td><td></td><td></td><td>C1O;</td><td>Cll;</td><td>C12;</td>
<td>A1O-B1O-</td><td>A1O-B1O-</td><td>A10-B10-</td><td>A1O-B1O-</td><td>A10-B10-</td><td>A1O-31O-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A1O-B1O-</td><td>A10-B10-</td><td>A10-B10-</td><td>A10-B10-</td><td>A1O-B1O-</td><td>A10-B10-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A10-B10-</td><td>A10-B10-</td><td>A10-B10-</td><td>A10-B10-</td><td>A1O-B1O-</td><td>A10-B10-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A1O-B1O-</td><td>A10-B10-</td><td>A10-B10-</td><td>A10-B10-</td><td>A10-B10-</td><td>A10-B10-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td>
<td>Α10-Β10-</td><td>A10-B10-</td><td>A1O-B1O- ·</td><td>A1O-B1O-</td><td>A1O-B1O-</td><td>A10-B10-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A10-B10-</td><td>A1O-B1O-</td><td>A1O-B1O-</td><td>A1O-B1O-</td><td>A11-B1O-C1;</td><td>A11-B10-C2;</td>
<td>C4 3; A11-B10-C3;</td><td>C4 4 ; A11-B10-C4;</td><td>C4 5; A11-B10-C5;</td><td>C4 6; A11-B10-C6;</td><td>A11-B10-C7;</td><td>A11-B10-C8;</td>
<td>A11-B10-C9;</td><td>A11-B10-</td><td>A11-B10-</td><td>A11-B1O-</td><td>A11-B1O-</td><td>A11-B10-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A11-B1O-</td><td>A11-B10-</td><td>A11-B10-</td><td>A11-B10-</td><td>A11-B10-</td><td>A11-B1O-</td>
<td>C15;</td><td>C16; <sup>!</sup></td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A11-B10-</td><td>A11-B10-</td><td>A11-B1O-</td><td>A11-B10-</td><td>A11-B10-</td><td>A11-B10-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>A11-B1O-</td><td>A11-B10-</td><td>A11-B1O-</td><td>A11-B10-</td><td>A11-B1O-</td><td>A11-B10-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A11-B10-</td><td>A11-B10-</td><td>A11-B10-</td><td>A11-B1O-</td><td>A11-B10-</td><td>A11-B10-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A11-B10-</td><td>A11-B10-</td><td>A11-B1O-</td><td>A11-B10-</td><td>A11-B10-</td><td>A11-B10-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>A11-B10-</td><td>A11-B1O-</td><td>A12-B10-C1;</td><td>A12-B10-C2;</td><td>A12-B10-C3;</td><td>A12-B10-C4;</td>
<td>C4 5; A12-B10-C5;</td><td>C4 6; A12-B1O-C6;</td><td>A12-310-C7;</td><td>A12-B1O-C8;</td><td>A12-B10-C9;</td><td>A12-B10-</td>
<td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>C1O; A12-B10-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td>
<td>C2 3;</td><td>C2 4 ;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A12-310-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td><td>A12-B10-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A13-B10-C1;</td><td>A13-B10-C2;</td><td>A13-310-C3;</td><td>A13-B1O-C4;</td><td>A13-B10-C5;</td><td>A13-B10-C6;</td>
<td>A13-B10-C7;</td><td>A13-B10-C8;</td><td>A13-310-C9;</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B20-</td>
<td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td><td>C1O; A13-B10-</td><td>Cll; A13-B10-</td><td>C12; A13-B10-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B10- '</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B1O-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A13-B10-</td><td>A13-B10-</td><td>A13-310-</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A13-B10-</td><td>A13-B10-</td><td>A13-310-</td><td>A13-B10-</td><td>A13-B10-</td><td>A13-B10-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A13-B10-</td><td>A13-B10- '</td><td>A13-B10-</td><td>A13-B10-</td><td>A14-B1O-C1;</td><td>A14-B10-C2;</td>
<td>C4 3; A14-B10-C3;</td><td>C 4 4 ; A14-B1O-C4;</td><td>C4 5; A14-B10-C5;</td><td>C4 6; A14-B1O-C6;</td><td>A14-B10-C7;</td><td>A14-B10-C8;</td>
<td>A14-B1O-C9;</td><td>A14-B1O-</td><td>A14-310-</td><td>A14-B10-</td><td>A14-B10-</td><td>A14-B10-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A14-B10-</td><td>A14-B1O-</td><td>A14-310-</td><td>A14-B10-</td><td>A14-B10-</td><td>A14-B1O-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A14-B1O-</td><td>A14-B10-</td><td>A14-B10-</td><td>A14-B1O-</td><td>A14-B10-</td><td>A14-B1O-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A14-B1O-</td><td>A14-B1O-</td><td>A14-31O-</td><td>A14-B1O-</td><td>A14-B1O-</td><td>A14-B10-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A14-B10-</td><td>A14-B1O-</td><td>A14-B10-</td><td>A14-B10-</td><td>A14-B10-</td><td>A14-B10-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>A14-310-</td><td>A14-B1O-</td><td>A14-B10-</td><td>A14-B1O-</td><td>A14-B1O-</td><td>A14-B1O-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A14-B10-</td><td>A14-B10-</td><td>A15-B10-C1;</td><td>A15-B1O-C2;</td><td>A15-B10-C3;</td><td>A15-B1O-C4;</td>
<td>C45;</td><td colspan="5">C4 6;</td>
<td>A15-B10-C5;</td><td>A15-B10-C6;</td><td>A15-B10-C7;</td><td>A15-B10-C8;</td><td>A15-B10-C9;</td><td>A15-B10-</td>
<td>Α15-Β10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>C1O; A15-B10-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C2O;</td><td>C21;</td><td>C22;</td>
<td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;,’</td><td>C34;</td>
<td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td><td>A15-B10-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A16-B10-C1;</td><td>A16-B10-C2;</td><td>A16-B10-C3;</td><td>A16-B10-C4;</td><td>A16-B10-C5;</td><td>A16-B10-C6;</td>
<td>A16-B10-C7;</td><td>A16-B10-C8;</td><td>A16-B10-C9;</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td>
<td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>C1O; A16-310-</td><td>Cll; A16-B10-</td><td>C12; A16-E10-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-BI0-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A16-310-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A16-310-</td><td>Α16-Β10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A16-B10-</td><td>A17-B10-C1;</td><td>A17-B10-C2;</td>
<td>C4 3; A17-B10-C3;</td><td>C4 4; A17-B10-C4;</td><td>C4 5; A17-B10-C5;</td><td>C4 6; A17-B10-C6;</td><td>A17-B10-C7;</td><td>A17-B10-C8;</td>
<td>A17-B10-C9;</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-E10-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-E10-</td><td>A17-B10-</td><td>A17-B10-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24; '</td><td>C25;</td><td>C2 6;</td>
<td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A17-310-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-B10-</td><td>A17-E10-</td>
<td>C3 9;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>A17-B10-</td><td>A17-B1O-</td><td>A18-B1O-C1;</td><td>A18-E10-C2;</td><td>A18-B10-C3;</td><td>A18-B10-C4;</td>
<td>C4 5; A18-310-C5;</td><td>C4 6; A18-B10-C6;</td><td>A18-B10-C7;</td><td>A18-B10-C8;</td><td>A18-B10-C9;</td><td>A18-B10-</td>
<td>A18-310-</td><td>A18-B10- </td><td>A18-B10-</td><td>Α18-Ξ10-</td><td>A18-B10-</td><td>C1O; A18-310-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A18-310-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-E10-</td><td>A18-B10-</td><td>A18-E10-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A18-B10-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-B10-</td>
<td>C23;</td><td>C2 4;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A18-B10-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-B10-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A18-310-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-31O-</td><td>A18-B10-</td><td>A18-B10-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A18-310-</td><td>A18-B10-</td><td>A18-B10-</td><td>A18-E10-</td><td>A18-B10-</td><td>A18-B10-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A19-310-C1;</td><td>A19-B10-C2;</td><td>A19-B10-C3;</td><td>A19-B10-C4;</td><td>A19-B10-C5;</td><td>A19-B10-C6;</td>
<td>A19-310-C7;</td><td>A19-B10-C8;</td><td>A19-B10-C9;</td><td>A19-B10-</td><td>A19-B10-</td><td>A19-B10-</td>
<td>A19-310-</td><td>A19-B10-</td><td>A19-B10-</td><td>C1O; A19-B10-</td><td>Cll; A19-B10-</td><td>C12; A19-B10-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α19-Β10-</td><td>A19-B10-</td><td>A19-B10-</td><td>A19-B10-</td><td>A19-B10-</td><td>A19-B10-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td>
<td>Α19-Β10-</td><td>A19-B10-</td><td>A19-B10-</td><td>A19-B10-</td><td>A19-B10-</td><td>A19-B10-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C3O;</td>
<td>Α19-Β10-</td><td>A19-B10-</td><td>A19-B1O-</td><td>A19-B10-</td><td>A19-B10-</td><td>Α19-Ξ10-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α19-Β10-</td><td>A19-B10-</td><td>A19-B1O-</td><td>A19-B10-</td><td>A19-B1O-</td><td>Α19-Ξ10-</td>
<td>C37;</td><td>C38;</td><td>C3 9;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α19-Β10-</td><td>A19-B10-</td><td>A19-B10-</td><td>A19-B10-</td><td>A20-B10-C1;</td><td>A2C-310-C2;</td>
<td>C4 3; A20-B10-C3;</td><td>C4 4 ; A20-B10-C4;</td><td>C4 5; A20-B10-C5;</td><td>C4 6; A20-B10-C6;</td><td>A20-B10-C7;</td><td>A2C--B10-C8;</td>
<td>A20-B10-C9;</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A2C-310-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>Α20-Β10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>Α20-Ξ10-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C2C;</td>
<td>Α20-Β10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A2C-310-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α20-Β10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A2C-310-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C3O;</td><td>C31;</td><td>C32;</td>
<td>Α20-Β10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A2C-310-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α20-Β10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A20-B10-</td><td>A2C-310-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α20-Β10-</td><td>A20-B10-</td><td>A21-B10-C1;</td><td>A21-B10-C2;</td><td>A21-B10-C3;</td><td>A21-310-C4;</td>
<td>C4 5; A21-B10-C5;</td><td>C4 6; A21-B10-C6;</td><td>A21-B10-C7;</td><td>A21-B10-C8;</td><td>A21-B10-C9;</td><td>A21-310-</td>
<td>Α21-Β10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B1O-</td><td>A21-B10-</td><td>CIC; A21-310-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>Clc;</td>
<td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-310-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A2L-310-</td>
<td>C23;</td><td>C2 4;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C2: ;</td>
<td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-310-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C3i;</td>
<td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>Α2'_-3ίΰ-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4C;</td>
<td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-B10-</td><td>A21-310-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A22-B10-C1;</td><td>A22-B10-C2;</td><td>A22-B10-C3;</td><td>A22-B1O-C4;</td><td>A22-B10-C5;</td><td>A22-B10-C6;</td>
<td>A22-B10-C7;</td><td>A22-B10-C8;</td><td>A22-B10-C9;</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-31O-</td>
<td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>C1O; A22-B10-</td><td>Cll; A22-B10-</td><td>C12; A22-310-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C1E;</td>
<td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-310-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A22-B10-</td><td>A22-B10- </td><td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-310-</td>
<td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A22-B10-</td><td>A22-B10-</td><td>A22-B1O-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-310-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-310-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A22-B10-</td><td>A23-B10-C1;</td><td>A23-310-C2;</td>
<td>C4 3; A23-B10-C3;</td><td>C4 4; A23-B10-C4;</td><td>C4 5; A23-B10-C5;</td><td>C4 6; A23-B1O-C6;</td><td>A23-B10-C7;</td><td>A23-310-C8;</td>
<td>A23-B10-C9;</td><td>A23-B10-</td><td>A23-B1O-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-310-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-310-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C2O;</td>
<td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-310-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-310-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α23-Β10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>Α23-Β10-</td><td>A23-B10-</td><td>A23-B1O-</td><td>A23-B10-</td><td>A23-B10-</td><td>A23-B10-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α23-Β10-</td><td>A23-B10-</td><td>A24-B10-C1;</td><td>A24-B10-C2;</td><td>A24-B10-C3;</td><td>A24-B10-C4;</td>
<td>C4 5; A24-B10-C5;</td><td>C4 6; A24-B10-C6;</td><td>A24-B1O-C7;</td><td>A24-B1O-C8;</td><td>A24-B10-C9;</td><td>A24-B10-</td>
<td>Α24-Β10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>C1O; A24-B10-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B1O-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C2O;</td><td>C21;</td><td>C22;</td>
<td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B1O-</td><td>A24-B1O-</td><td>A24-B10-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B1O-</td><td>A24-B10-</td><td>A24-B10-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B10-</td><td>A24-B1O-</td><td>A24-B10-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A25-B10-C1;</td><td>A25-B10-C2;</td><td>A25-B10-C3;</td><td>A25-B10-C4;</td><td>A25-B10-C5;</td><td>A25-B10-C6;</td>
<td>A25-E10-C7;</td><td>A25-B10-C8;</td><td>A25-B10-C9;</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td>
<td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>C1O; A25-B10-</td><td>Cll; A25-B10-</td><td>C12; A25-B10-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A25-B10-</td><td>A26-B10-C1;</td><td>A26-B10-C2;</td>
<td>C4 3; A26-B10-C3;</td><td>C4 4; A26-B10-C4;</td><td>C4 5; A26-B10-C5;</td><td>C4 6; A26-B10-C6;</td><td>A26-B1O-C7;</td><td>A26-B10-C8;</td>
<td>A26-B10-C9;</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B1O-</td><td>A26-B10-</td><td>A26-B10-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C2-0;</td>
<td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C2 5;</td><td>C2 6;</td>
<td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td>
<td>C33;</td><td>C34; '</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td><td>A26-B10-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>A26-B10-</td><td>A26-B10-</td><td>A27-B10-C1;</td><td>A27-B10-C2;</td><td>A27-B10-C3;</td><td>A27-B10-C4;</td>
<td>C4 5; A27-B10-C5;</td><td>C4 6; A27-B10-C6;</td><td>A27-B10-C7;</td><td>A27-B10-C8;</td><td>A27-B10-C9;</td><td>A27-B10-</td>
<td>A27-B10-</td><td>A27-310-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>C1O; A27-B10-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td>
<td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33 ;</td><td>C34;</td>
<td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>Α27-Β10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td><td>A27-B10-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A28-B10-C1;</td><td>A28-B10-C2;</td><td>A28-B10-C3;</td><td>A28-B10-C4;</td><td>A28-B1O-C5;</td><td>A28-B10-C6;</td>
<td>A28-B10-C7;</td><td>A28-B10-C8;</td><td>A28-B10-C9;</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td>
<td>Α28-Β10-</td><td>A28-B10-</td><td>A28-B10-</td><td>C1O; A28-B10-</td><td>Cll; A28-B10-</td><td>C12; A28-B10-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17 ;</td><td>C18;</td>
<td>Α28-Β10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B1O-</td><td>Α28-Ξ10-</td>
<td>C19 ;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24 ;</td>
<td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>Α28-Ξ10-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td><td>A28-B10-</td>
<td>C37;</td><td>C38;</td><td>C39 ;</td><td>C4O;</td><td>C41;</td><td>C42;</td>
<td>A28-B10-</td><td>A28-B10-</td><td>A28-B1O-</td><td>A28-B10-</td><td>A1-B11-C1;</td><td>A1-B11-C2;</td>
<td>C4 3; A1-B11-C3;</td><td>C4 4; A1-B11-C4;</td><td>C4 5; A1-B11-C5;</td><td>C4 6; A1-B11-C6;</td><td>A1-B11-C7;</td><td>A1-B11-C8;</td>
<td>A1-B11-C9;</td><td>A1-B11-C10;</td><td>A1-B11-C11;</td><td>A1-B11-C12;</td><td>A1-B11-C13;</td><td>A1-B11-C14;</td>
<td>A1-B11-C15;</td><td>A1-B11-C16;</td><td>A1-B11-C17;</td><td>Al-Bl1-C18;</td><td>A1-B11-C19;</td><td>A1-B11-C20;</td>
<td>A1-B11-C21;</td><td>A1-B11-C22;</td><td>A1-B11-C23;</td><td>A1-B11-C24;</td><td>A1-B11-C25;</td><td>A1-B11-C26;</td>
<td>A1-B11-C27;</td><td>A1-B11-C28;</td><td>A1-B11-C29;</td><td>A1-B11-C30;</td><td>A1-B11-C31;</td><td>A1-B11-C32;</td>
<td>A1-B11-C33;</td><td>A1-B11-C34;</td><td>A1-B11-C35;</td><td>A1-B11-C36;</td><td>A1-B11-C37;</td><td>A1-B11-C38;</td>
<td>A1-B11-C39;</td><td>A1-B11-C40;</td><td>A1-B11-C41;</td><td>A1-B11-C42;</td><td>A1-B11-C43;</td><td>A1-B11-C44;</td>
<td>A1-B11-C45;</td><td>A1-B11-C46;</td><td>A2-B11-C1;</td><td>A2-B11-C2;</td><td>A2-B11-C3;</td><td>A2-B11-C4;</td>
<td>A2-B11-C5;</td><td>A2-B11-C6;</td><td>A2-B11-C7;</td><td>A2-B11-C8;</td><td>A2-B11-C9;</td><td>A2-B11-C10;</td>
<td>A2-B11-C11;</td><td>A2-B11-C12;</td><td>A2-B11-C13;</td><td>A2-B11-C14;</td><td>A2-B11-C15;</td><td>Α2-Β11-Ο16;</td>
<td>A2-B11-C17;</td><td>A2-B11-CÍ8;</td><td>A2-B11-C19;</td><td>A2-B11-C20;</td><td>A2-B11-C21;</td><td>A2-B11-C22;</td>
<td>A2-B11-C23;</td><td>A2-B11-C24;</td><td>A2-B11-C25;</td><td>A2-B11-C26;</td><td>A2-B11-C27;</td><td>A2-B11-C28;</td>
<td>A2-B11-C29;</td><td>A2-B11-C30;</td><td>A2-B11-C31;</td><td>A2-B11-C32;</td><td>A2-B11-C33;</td><td>A2-B11-C34;</td>
<td>A2-B11-C35;</td><td>A2-B11-C36;</td><td>A2-B11-C37;</td><td>A2-B11-C38;</td><td>A2-B11-C39;</td><td>A2-B11-C40;</td>
<td>A2-B11-C41;</td><td>A2-B11-C42;</td><td>A2-B11-C43;</td><td>A2-B11-C44;</td><td>A2-B11-C45;</td><td>A2-B11-C46;</td>
<td>A3-B11-C1;</td><td>A3-B11-C2;</td><td>A3-B11-C3;</td><td>A3-B11-C4;</td><td>A3-B11-C5;</td><td>A3-B11-C6;</td>
<td>A3-B11-C7;</td><td>A3-B11-C8;</td><td>A3-B11-C9;</td><td>A3-B11-C10;</td><td>A3-B11-C11;</td><td>A3-B11-C12;</td>
<td>A3-B11-C13;</td><td>A3-B11-C14;</td><td>A3-BU-C15;</td><td>A3-B11-C16;</td><td>A3-B11-C17;</td><td>A3-B11-C18;</td>
<td>A3-B11-C19;</td><td>A3-B11-C20;</td><td>A3-B11-C21;</td><td>A3-B11-C22;</td><td>A3-B11-C23;</td><td>A3-B11-C24;</td>
<td>A3-B11-C25;</td><td>A3-B11-C26;</td><td>A3-B11-C27;</td><td>A3-B11-C28;</td><td>A3-B11-C29;</td><td>A3-B11-C30;</td>
<td>A3-B11-C31;</td><td>A3-B11-C32;</td><td>A3-B11-C33;</td><td>A3-B11-C34;</td><td>A3-B11-C35;</td><td>A3-BÍ1-C36;</td>
<td>A3-BU-C37;</td><td>A3-B11-C38;</td><td>A3-B11-C39;</td><td>A3-B11-C40;</td><td>A3-B11-C41;</td><td>A3-B11-C42;</td>
<td>A3-B11-C43;</td><td>. A3-B11-C44;</td><td>A3-B11-C45;</td><td>A3-B11-C46;</td><td>A4-B11-C1;</td><td>A4-B11-C2;</td>
<td>A4-B11-C3;</td><td>A4-B11-C4;</td><td>A4-B11-C5;</td><td>A4-B11-C6;</td><td>A4-B11-C7;</td><td>A4-B11-C8;</td>
<td>A4-B11-C9;</td><td>A4-B11-C1O;</td><td>A4-B11-C11;</td><td>A4-B11-C12;</td><td>A4-B11-C13;</td><td>A4-B11-C14;</td>
<td>A4-B11-C15;</td><td>A4-B11-C16;</td><td>A4-B11-C17;</td><td>A4-B11-C18;</td><td>A4-B11-C19;</td><td>A4-B11-C20;</td>
<td>A4-B11-C21;</td><td>A4-B11-C22;</td><td>A4-B11-C23;</td><td>A4-B11-C24;</td><td>A4-B11-C25;</td><td>A4-B11-C26;</td>
<td>A4-B11-C27;</td><td>A4-B11-C28;</td><td>A4-B11-C29;</td><td>A4-B11-C30;</td><td>A4-B11-C31;</td><td>Α4-Β·.1-Ο32;</td>
<td>A4-B11-C33;</td><td>A4-B11-C34;</td><td>A4-B11-C35;</td><td>A4-B11-C36;</td><td>A4-B11-C37;</td><td>A4-B11-C38;</td>
<td>A4-B11-C39;</td><td>A4-B11-C4O;</td><td>A4-B11-C41;</td><td>A4-B11-C42;</td><td>A4-B11-C43;</td><td>A4-B1L-C44;</td>
<td>A4-B11-C45;</td><td>A4-B11-C46·;</td><td>A5-B11-C1;</td><td>A5-B11-C2;</td><td>A5-B11-C3;</td><td>A5-B11-C4;</td>
<td>A5-B11-C5;</td><td>A5-B11-C6;</td><td>A5-B11-C7;</td><td>A5-B11-C8;</td><td>A5-B11-C9;</td><td>A5-B11-C10;</td>
<td>A5-B11-C11;</td><td>A5-B11-C12;</td><td>A5-B11-C13;</td><td>A5-B11-C14;</td><td>A5-B11-C15;</td><td>A5-B11-C16;</td>
<td>A5-B11-C17;</td><td>A5-B11-C18;</td><td>A5-B11-C19;</td><td>A5-B11-C20;</td><td>A5-B11-C21;</td><td>A5-B11-C22;</td>
<td>A5-B11-C23;</td><td>A5-B11-C24;</td><td>A5-B11-C25;</td><td>A5-B11-C26;</td><td>A5-B11-C27;</td><td>A5-B11-C28;</td>
<td>A5-B11-C29;</td><td>A5-B11-C30;</td><td>A5-B11-C31;</td><td>A5-B11-C32;</td><td>A5-B11-C33;</td><td>A5-B11-C34;</td>
<td>A5-B11-C35;</td><td>A5-B11-C36;</td><td>A5-B11-C37;</td><td>A5-B11-C38;</td><td>A5-B11-C39;</td><td>A5-B11-C40;</td>
<td>A5-B11-C41;</td><td>A5-B11-C42;</td><td>A5-B11-C43;</td><td>A5-B11-C44;</td><td>A5-B11-C45;</td><td>A5-B11-C46;</td>
<td>A6-B11-C1;</td><td>A6-B11-C2;</td><td>A6-B11-C3;</td><td>A6-B11-C4;</td><td>A6-B11-C5;</td><td>A6-B11-C6;</td>
<td>A6-B11-C7;</td><td>A6-B11-C8;</td><td>A6-B11-C9;</td><td>A6-B11-C10;</td><td>A6-B11-C11;</td><td>A6-B11-C12;</td>
<td>A6-B11-C13;</td><td>A6-B11-C14;</td><td>A6-B11-C15;</td><td>A6-B11-C16;</td><td>A6-B11-C17;</td><td>A6-B11-C18;</td>
<td>A6-B11-C19;</td><td>A6-B11-C20;</td><td>A6-B11-C21;</td><td>A6-B11-C22;</td><td>A6-B11-C23;</td><td>A6-B11-C24;</td>
<td>A6-B11-C25;</td><td>A6-B11-C26;</td><td>A6-B11-C27;</td><td>A6-B11-C28;</td><td>A6-B11-C29;</td><td>A6-B11-C30;</td>
<td>A6-B11-C31;</td><td>A6-B11-C32;</td><td>A6-B11-C33;</td><td>A6-B11-C34;</td><td>A6-B11-C35;</td><td>A6-B11-C36;</td>
<td>A6-B11-C37;</td><td>A6-B11-C38;</td><td>A6-B11-C39;</td><td>A6-B11-C40;</td><td>A6-B11-C41;</td><td>A6-B11-C42;</td>
<td>A6-B11-C43;</td><td>A6-B11-C44;</td><td>A6-B11-C45;</td><td>A6-B11-C46;</td><td>A7-B11-C1;</td><td>A7-B11-C2;</td>
<td>A7-B11-C3;</td><td>A7-B11-C4;</td><td>A7-BÍ1-C5;</td><td>A7-B11-C6;</td><td>A7-B11-C7;</td><td>A7-B11-C8;</td>
<td>A7-B11-C9;</td><td>A7-B11-C10;</td><td>A7-B11-C11;</td><td>A7-B1I-C12;</td><td>A7-B11-C13;</td><td>A7-B11-C14;</td>
<td>A7-B11-C15;</td><td>A7-B11-C16;</td><td>A7-B11-C17;</td><td>A7-B11-C18;</td><td>A7-B11-C19;</td><td>A7-B11-C20;</td>
<td>A7-B11-C21;</td><td>A7-B11-C22;</td><td>A7-B11-C23;</td><td>A7-B11-C24;</td><td>A7-B11-C25;</td><td>A7-B11-C26;</td>
<td>A7-B11-C27;</td><td>A7-B11-C28;</td><td>A7-B11-C29;</td><td>A7-B11-C3O;</td><td>A7-B11-C31;</td><td>A7-B11-C32;</td>
<td>A7-B11-C33;</td><td>A7-BU-C34;</td><td>A7-B11-C35;</td><td>A7-B11-C36;</td><td>A7-B11-C37;</td><td>A7-B11-C38;</td>
<td>A7-B11-C39;</td><td>A7-B11-C4O;</td><td>A7-B11-C41;</td><td>A7-B11-C42;</td><td>A7-B11-C43;</td><td>A7-B11-C44;</td>
<td>A7-B11-C45;</td><td>A7-B11-C46;</td><td>A8-B11-C1;</td><td>A8-BU-C2;</td><td>A8-B11-C3;</td><td>A8-B11-C4;</td>
<td>A8-B11-C5;</td><td>A8-B11-C6;</td><td>A8-B11-C7;</td><td>A8-B11-C8;</td><td>A8-B11-C9;</td><td>A8-B11-C1O;</td>
<td>A8-B11-C11;</td><td>A8-B11-C12;</td><td>A8-B11-C13;</td><td>A8-B11-C14;</td><td>A8-B11-C15;</td><td>A8-B11-C16;</td>
<td>A8-B11-C17;</td><td>A8-B11-C18;</td><td>A8-B11-C19;</td><td>A8-B11-C20;</td><td>A8-B11-C21;</td><td>A8-B17-C22;</td>
<td>A8-B11-C23;</td><td>A8-B11-C24;</td><td>A8-B11-C25;</td><td>A8-B11-C26;</td><td>A8-B11-C27;</td><td>A8-B1L-C28;</td>
<td>A8-B11-C29;</td><td>A8-B11-C3O;</td><td>A8-B11-C31;</td><td>A8-B11-C32;</td><td>A8-B11-C33;</td><td>A8-B1L-C34;</td>
<td>A8-B11-C35;</td><td>A8-B11-C36;</td><td>A8-B11-C37;</td><td>A8-B11-C38;</td><td>A8-B11-C39;</td><td>A8-B1L-C4O;</td>
<td>A8-B11-C41;</td><td>A8-B11-C42;</td><td>A8-B11-C43;</td><td>A8-B11-C44;</td><td>A8-B11-C45;</td><td>A8-B1L-C46;</td>
<td>A9-B11-C1;</td><td>A9-B11-C2;</td><td>A9-B11-C3;</td><td>A9-B11-C4;</td><td>A9-B11-C5;</td><td>A9-B11-C6;</td>
<td>A9-B11-C7;</td><td>A9-B11-C8;</td><td>A9-B11-C9;</td><td>A9-B11-C1O;</td><td>A9-B11-C11;</td><td>A9-Bľ_-C12;</td>
<td>A9-B11-C13;</td><td>A9-B11-C14;</td><td>A9-B11-C15;</td><td>A9-B11-C16;</td><td>A9-B11-C17;</td><td>A9-B1L-C18;</td>
<td>A9-BU-C19;</td><td>A9-B11-C2O;</td><td>A9-B11-C21;</td><td>A9-B11-C22;</td><td>A9-B11-C23;</td><td>A9-B1L-C24;</td>
<td>A9-B11-C25;</td><td>A9-B11-C26;</td><td>A9-B11-C27;</td><td>A9-B11-C28;</td><td>A9-B11-C29;</td><td>A9-B11-C30;</td>
<td>A9-B11-C31;</td><td>A9-B11-C32;</td><td>A9-B11-C33;</td><td>A9-B11-C34;</td><td>A9-B11-C35;</td><td>A9-B13-C36;</td>
<td>A9-B11-C37;</td><td>A9-B11-C38;</td><td>A9-B11-C39;</td><td>A9-B11-C40;</td><td>A9-B11-C41;</td><td>A9-B11-C42;</td>
<td>A9-B11-C43;</td><td>A9-B11-C44 ;</td><td>A9-B11-C45;</td><td>A9-B11-C46;</td><td>A1O-B11-C1;</td><td>A10-B11-C2;</td>
<td>A10-B11-C3;</td><td>A10-B11-C4;</td><td>A10-B11-C5;</td><td>A1O-B11-C6;</td><td>A10-B11-C7;</td><td>A10-B11-C8;</td>
<td>A10-B11-C9;</td><td>A1O-B11-</td><td>A10-B11-</td><td>A1O-B11-</td><td>A10-B11-</td><td>A1O-B11-</td>
<td>Α10-Β11-</td><td>C1O; A1O-B11-</td><td>Cll; A1O-B11-</td><td>C12; A1O-B11-</td><td>C13; A1O-B11-</td><td>C14; A1O-B11-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C2 0;</td>
<td>A1O-B11-</td><td>A10-B11-</td><td>A1O-B11-</td><td>A1O-B11-</td><td>A1O-B11-</td><td>A10-B11-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A1O-B11-</td><td>A1O-B11-</td><td>A10-B11-</td><td>A10-B11-</td><td>A1O-B11-</td><td>AlO-Bll·-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A1O-B11-</td><td>A1O-B11-</td><td>A10-B11-</td><td>A1O-B11-</td><td>A1O-B11-</td><td>Α1Ο-Ξ11-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A1O-B11-</td><td>A10-B11-</td><td>A1O-B11-</td><td>A10-B11-</td><td>A1O-B11-</td><td>A1O-E31-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A10-B11-</td><td>A1O-B11-</td><td>A11-B11-C1;</td><td>A11-B11-C2;</td><td>A11-B11-C3;</td><td>A11-EL1-C4;</td>
<td>C4 5; A11-B11-C5;</td><td>C4 6; A11-B11-C6;</td><td>A11-B11-C7;</td><td>A11-B11-C8;</td><td>A11-B11-C9;</td><td>All-Eľl-</td>
<td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>C1O; Α11-Ξ31-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Eľl-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C2O;</td><td>C21;</td><td>C22;</td>
<td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Eľl-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Ell-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>All-Bll-</td><td>Α11-Ξ11-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A12-B11-C1;</td><td>A12-B11-C2;</td><td>A12-B11-C3;</td><td>A12-B11-C4;</td><td>A12-B11-C5;</td><td>A12-E-.1-C6;</td>
<td>A12-B11-C7;</td><td>A12-B11-C8;</td><td>A12-B11-C9;</td><td>A12-B11-</td><td>A12-B11-</td><td>Α12-Ξ11-</td>
<td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>C1O; A12-B11-</td><td>Cll; A12-B11-</td><td>C12; A12-B11-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-BL1-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α12-Β11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α12-Β11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A12-B11-</td><td>A13-B11-C1;</td><td>A13-B11-C2</td>
<td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
<td>A13-B11-C3;</td><td>A13-B11-C4;</td><td>A13-B11-C5;</td><td>'A13-B11-C6;</td><td>A13-B11-C7;</td><td>A13-B11-C8</td>
<td>A13-B11-C9;</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>Α13-Β11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α13-Β11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td>
<td>Α13-Β11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α13-Β11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α13-Β11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td><td>A13-B11-</td>
<td>C3 9 ;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A13-B11-</td><td>A13-B11-</td><td>A14-B11-C1;</td><td>A14-B11-C2;</td><td>A14-B11-C3;</td><td>A14-B11-C4</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td>
<td>A14-B11-C5;</td><td>A14-B11-C6;</td><td>A14-B11-C7;</td><td>A14-B11-C8;</td><td>A14-B11-C9;</td><td>A14-B11- C1Ó;</td>
<td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td>
<td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td><td>A14-B11-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A15-B11-C1;</td><td>A15-B11-C2;</td><td>A15-B11-C3;</td><td>A15-B11-C4;</td><td>A15-B11-C5;</td><td>A15-B11-C6</td>
<td>A15-B11-C7;</td><td>A15-B11-C8;</td><td>A15-B11-C9;</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td>
<td></td><td></td><td></td><td>C1O;</td><td>Cll;</td><td>C12;</td>
<td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td>
<td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C3O;</td>
<td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A15-B11-</td><td>A16-B11-C1;</td><td>A16-B11-C2</td>
<td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
<td>A16-B11-C3;</td><td>A16-B11-C4;</td><td>A16-B11-C5;</td><td>A16-B11-C6;</td><td>A16-B11-C7;</td><td>A16-B11-C8</td>
<td>A16-B11-C9;</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C2 0;</td>
<td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td><td>C2 5;</td><td>C2 6;</td>
<td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C3O;</td><td>C31;</td><td>C32;</td>
<td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td>
<td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td><td>A16-B11-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A16-B11-</td><td>A16-B11-</td><td>A17-B11-C1;</td><td>A17-B11-C2;</td><td>A17-B11-C3;</td><td>A17-B11-C4</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td>
<td>A17-B11-C5;</td><td>A17-B11-C6;</td><td>A17-B11-C7;</td><td>A17-B11-C8;</td><td>A17-B11-C9;</td><td>A17-B11- C1O;</td>
<td>Α17-Β11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C2 0;</td><td>C21;</td><td>C22;</td>
<td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2S;</td><td>C27;</td><td>C28;</td>
<td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>'A17-B11-</td><td>A17-B11-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td><td>A17-B11-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A18-B11-C1;</td><td>A18-B11-C2;</td><td>A18-B11-C3;</td><td>A18-B11-C4;</td><td>A18-B11-C5;</td><td>A18-B11-C6</td>
<td>A18-B11-C7;</td><td>A18-B11-C8;</td><td>A18-B11-C9;</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td>
<td>A18-B11-</td><td>A18-B11-</td><td>A18-B11- ’</td><td>C1O; A18-B11-</td><td>Cll; A18-B11-</td><td>C12; A18-B11-</td>
<td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td>
<td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A18-B11-</td><td>A19-B11-C1;</td><td>A19-B11-C2</td>
<td>C4 3; A19-B11-C3;</td><td>C4 4; A19-B11-C4;</td><td>C4 5; A19-B11-C5;</td><td>C4 6; A19-B11-C6;</td><td>A19-B11-C7;</td><td>A19-B11-C8</td>
<td>A19-B11-C9;</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C1S;</td><td>C19;</td><td>C20;</td>
<td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td><td>A19-B11-</td>
<td>C3 9;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A19-B11-</td><td>A19-B11-</td><td>A20-B11-C1;</td><td>A2O-B11-C2;</td><td>'A20-B11-C3;</td><td>A20-B11-C4</td>
<td>C4 5; A20-B11-C5;</td><td>C4 6; A20-B11-C6;</td><td>A20-B11-C7;</td><td>A20-B11-C8;</td><td>A20-B11-C9;</td><td>Α20-Ξ11-</td>
<td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>C1O; A20-B11-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C'16;</td>
<td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A2O-B11-</td><td>A20-B11-</td><td>A20-B11-</td>
<td>C23;</td><td>C24 ;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A2O-B11-</td><td>A20-B11-</td><td>A20-E11-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>A20-B11-</td><td>Ά20-Β11-</td><td>A20-B11-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A21-B11-C1;</td><td>A21-B11-C2;</td><td>A21-B11-C3;</td><td>A21-B11-C4;</td><td>A21-B11-C5;</td><td>A21-B11-C6</td>
<td>A21-B11-C7;</td><td>A21-B11-C8;</td><td>A21-B11-C9;</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td>
<td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>C1O; A21-B11-</td><td>Cll; A21-B11-</td><td>C12; A21-B11-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α21-Β11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>Α21-Β11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>Α21-Β11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td>
<td>Α21-Β11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>Α21-Β11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A21-B11-</td><td>A22-B11-C1;</td><td>A22-B11-C2;</td>
<td>C4 3; A22-B11-C3;</td><td>C4 4; A22-B11-C4;</td><td>C4 5; A22-B11-C5;</td><td>C46; A22-B11-C6;</td><td>A22-B11-C7;</td><td>A22-B11-C8;</td>
<td>A22-B11-C9;</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>Α22-Β11-</td><td>A22-B11-</td><td>A22-B11-</td><td>Α22-Β11-</td><td>A22-B11-</td><td>A22-B11-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α22-Β11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>Α22-Β11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α22-Β11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38 ;</td>
<td>Α22-Β11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td><td>A22-B11-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α22-Β11-</td><td>A22-B11-</td><td>A23-B11-C1;</td><td>A23-B11-C2;</td><td>A23-B11-C3;</td><td>A23-B11-C4;</td>
<td>C4 5; A23-B11-C5;</td><td>C4 6; A23-B11-C6;</td><td>A23-B11-C7;</td><td>A23-B11-C8;</td><td>A23-B11-C9;</td><td>A23-B11-</td>
<td>Α23-Β11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>C10; A23-B11-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A23-B11-</td><td>Α23-Β1Ί-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td><td>A23-B11-</td>
<td>C41;</td><td> C42;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A24-B11-C1;</td><td>A24-B11-C2;</td><td>A24-B11-C3;</td><td>A24-B11-C4;</td><td>A24-B11-C5;</td><td>A24-B11-C6;</td>
<td>A24-B11-C7;</td><td>A24-B11-C8;</td><td>A24-B11-C9;</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td>
<td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>C10; A24-B11-</td><td>Cll; A24-B11-</td><td>C12; A24-B11-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td>
<td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td>
<td>C2 5;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td>
<td>C37 ;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A24-B11-</td><td>A25-BÍ1-C1;</td><td>A25-B11-C2;</td>
<td>C4 3; A25-B11-C3;</td><td>C4 4; A25-B11-C4;</td><td>C4 5; A25-B11-C5;</td><td>C4 6; A25-B11-C6;</td><td>A25-B11-C7;</td><td>A25-B11-C8;</td>
<td>A25-B11-C9;</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A25-B11-</td><td>A25-B11-</td><td>A25-BU-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α25-Β11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α25-Β11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td><td>A25-B11-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α25-Β11-</td><td>A25-B11-</td><td>A26-B11-C1;</td><td>A26-B11-C2;</td><td>A26-B11-C3;</td><td>A26-B11-C4;</td>
<td>C4 5; A26-B11-C5;</td><td>C4 6; A26-B11-C6;</td><td>A26-B11-C7;</td><td>A26-B11-C8;</td><td>A26-B11-C9;</td><td>A26-B11-</td>
<td>Α26-Β11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11--</td><td>A26-B11-</td><td>C1O; A26-B11-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-EL1-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B1Í-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>Č4 0;</td>
<td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-B11-</td><td>A26-BÍ1-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A27-B11-C1;</td><td>A27-B11-C2;</td><td>A27-B11-C3;</td><td>A27-B11-C4;</td><td>A27-B11-C5;</td><td>Α27-Β-1-Ο6;</td>
<td>A27-B11-C7;</td><td>A27-B11-C8;</td><td>A27-B11-C9;</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-Eľl·-</td>
<td>Α27-Β11-</td><td>Α27-Β11-</td><td>A27-B11-</td><td>C1O; A27-B11-</td><td>Cll; A27-B11-</td><td>C12; A27-B11-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-E11-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B-1-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>A27-B11-</td><td>Α27-Ε1Ϊ-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A27-B11-</td><td>A27-B11- '</td><td>A27-B11-</td><td>A27-B11-</td><td>A28-B11-C1;</td><td>A28-B11-C2;</td>
<td>C4 3; A28-B11-C3;</td><td>C4 4 ; A28-B11-C4;</td><td>C4 5; A28-B11-C5;</td><td>C4 6; A28-B11-C6;</td><td>A28-B11-C7;</td><td>Α28-Ε11-α8;</td>
<td>A28-B11-C9;</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-Ell·-</td>
<td>A28-B11-</td><td>C10; A28-.B11-</td><td>Cll; A28-B11-</td><td>C12; A28-B11-</td><td>C13; A28-B11-</td><td>C14; A28-B11-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-E’_l-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-E11-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-B11-</td><td>A28-E11-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A28-B11-</td><td>A28-B11-</td><td>A1-B12-C1;</td><td>A1-B12-C2;</td><td>A1-B12-C3;</td><td>A1-B12-C4;</td>
<td>C4 5; A1-B12-C5;</td><td>C4 6; A1-B12-C6;</td><td>A1-B12-C7;</td><td>A1-B12-C8;</td><td>A1-B12-C9;</td><td>A1-B12-C10;</td>
<td>A1-B12-C11;</td><td>A1-B12-C12;</td><td>A1-B12-C13;</td><td>A1-B12-C14;</td><td>A1-B12-C15;</td><td>A1-B12-C16;</td>
<td>A1-B12-C17;</td><td>A1-B12-C18;</td><td>A1-B12-C19;</td><td>A1-B12-C20;</td><td>A1-B12-C21;</td><td>A1-B12-C22;</td>
<td>A1-B12-C23;</td><td>A1-B12-C24;</td><td>A1-B12-C25;</td><td>A1-B12-C26;</td><td>A1-B12-C27;</td><td>A1-B12-C28;</td>
<td>A1-B12-C29;</td><td>A1-B12-C30;</td><td>A1-B12-C31;</td><td>A1-B12-C32;</td><td>A1-B12-C33;</td><td>A1-B12-C34;</td>
<td>A1-B12-C35;</td><td>A1-B12-C36;</td><td>A1-B12-C37;</td><td>A1-B12-C38;</td><td>A1-B12-C39;</td><td>A1-B12-C40;</td>
<td>A1-B12-C41;</td><td>A1-212-C42;</td><td>A1-B12-C43;</td><td>A1-B12-C44;</td><td>A1-B12-C45;</td><td>A1-B12-C46;</td>
<td>A2-E12-C1;</td><td>A2-B12-C2;</td><td>A2-B12-C3;</td><td>A2-B12-C4;</td><td>A2-B12-C5;</td><td>A2-B12-C6;</td>
<td>A2-B12-C7;</td><td>A2-B12-C8;</td><td>A2-B12-C9;</td><td>A2-B12-C10;</td><td>A2-B12-C11;</td><td>A2-B12-C12;</td>
<td>A2-B12-C13;</td><td>A2-B12-C14;</td><td>A2-B12-C15;</td><td>A2-B12-C16;</td><td>A2-B12-C17;</td><td>A2-B12-C18;</td>
<td>A2-B12-C19;</td><td>A2-B12-C20;</td><td>A2-B12-C21;</td><td>A2-B12-C22;</td><td>A2-B12-C23;</td><td>A2-B12-C24;</td>
<td>A2-B12-C25;</td><td>A2-B12-C26;</td><td>A2-B12-C27;</td><td>A2-B12-C28;</td><td>A2-B12-C29;</td><td>A2-B12-C30;</td>
<td>A2-B12-C31;</td><td>A2-B12-C32;</td><td>A2-B12-C33;</td><td>A2-B12-C34;</td><td>A2-B12-C35;</td><td>A2-B12-C36;</td>
<td>A2-B12-C37;</td><td>A2-B12-C38;</td><td>A2-B12-C39;</td><td>A2-B12-C40;</td><td>A2-B12-C41;</td><td>A2-B12-C42;</td>
<td>A2-B12-C43;</td><td>A2-B12-C44;</td><td>A2-B12-C45;</td><td>A2-B12-C46;</td><td>A3-B12-C1;</td><td>A3-B12-C2;</td>
<td>A3-B12-C3;</td><td>A3-B12-C4;</td><td>A3-B12-C5;</td><td>A3-B12-C6;</td><td>A3-B12-C7;</td><td>A3-B12-C8;</td>
<td>A3-B12-C9;</td><td>A3-B12-C10;</td><td>A3-B12-C11;</td><td>A3-B12-C12;</td><td>A3-B12-C13;</td><td>A3-B12-C14;</td>
<td>A3-B12-C15;</td><td>A3-B12-C16;</td><td>A3-B12-C17;</td><td>A3-B12-C18;</td><td>A3-B12-C19;</td><td>A3-B12-C20;</td>
<td>A3-B12-C21;</td><td>A3-B12-C22;</td><td>A3-B12-C23;</td><td>A3-B12-C24;</td><td>A3-B12-C25;</td><td>A3-B12-C26;</td>
<td>A3-B12-C27;</td><td>A3-B12-C28;</td><td>A3-B12-C29;</td><td>A3-B12-C30;</td><td>A3-B12-C31;</td><td>A3-B12-C32;</td>
<td>A3-B12-C33;</td><td>A3-B12-C34;</td><td>A3-B12-C35;</td><td>A3-B12-C36;</td><td>A3-B12-C37;</td><td>A3-B12-C38;</td>
<td>A3-B12-C39;</td><td>A3-B12-C40;</td><td>A3-B12-C41;</td><td>A3-B12-C42;</td><td>A3-B12-C43;</td><td>A3-B12-C44;</td>
<td>A3-B12-C45;</td><td>A3-B12-C46;</td><td>A4-B12-C1;</td><td>A4-B12-C2;</td><td>A4-B12-C3;</td><td>Α4-Β12-Ο4;</td>
<td>A4-B12-C5;</td><td>A4-B12-C6;</td><td>A4-B12-C7;</td><td>A4-B12-C8;</td><td>A4-B12-C9;</td><td>A4-B12-C10;</td>
<td>A4-B12-C11;</td><td>A4-B12-C12;</td><td>A4-B12-C13;</td><td>A4-B12-C14;</td><td>A4-B12-C15;</td><td>A4-B12-C16;</td>
<td>A4-B12-C17;</td><td>A4-B12-C18;</td><td>A4-B12-C19;</td><td>A4-B12-C20;</td><td>A4-B12-C21;</td><td>A4-B12-C22;</td>
<td>A4-B12-C23;</td><td>A4-B12-C24;</td><td>A4-B12-C25;</td><td>A4-B12-C26;</td><td>A4-B12-C27;</td><td>A4-B12-C28;</td>
<td>A4-B12-C29;</td><td>A4-B12-C30;</td><td>A4-B12-C31;</td><td>A4-B12-C32;</td><td>A4-B12-C33;</td><td>A4-B12-C34;</td>
<td>A4-B12-C35;</td><td>A4-B12-C36;</td><td>A4-B12-C37;</td><td>A4-B12-C38;</td><td>A4-B12-C39;</td><td>A4-B12-C40;</td>
<td>A4-B12-C41;</td><td>A4-B12-C42;</td><td>A4-B12-C43;</td><td>A4-B12-C44;</td><td>A4-B12-C45;</td><td>A4-B12-C46;</td>
<td>A5-B12-C1;</td><td>A5-B12-C2;</td><td>A5-B12-C3;</td><td>A5-B12-C4;</td><td>A5-B12-C5;</td><td>A5-B12-C6;</td>
<td>A5-B12-C7;</td><td>A5-B12-C8;</td><td>A5-B12-C9;</td><td>A5-B12-C10;</td><td>A5-B12-C11;</td><td>A5-B12-C12;</td>
<td>A5-B12-CI3;</td><td>A5-B12-C14;</td><td>A5-B12-C15;</td><td>A5-B12-C16;</td><td>A5-B12-C17;</td><td>A5-B12-C18;</td>
<td>A5-B12-C19;</td><td>A5-B12-C20;</td><td>A5-B12-C21;</td><td>A5-B12-C22;</td><td>A5-B12-C23;</td><td>A5-B12-C24;</td>
<td>A5-B12-C25;</td><td>A5-B12-C26;</td><td>A5-B12-C27;</td><td>A5-B12-C28;</td><td>A5-B12-C29;</td><td>A5-312-C30;</td>
<td>A5-B12-C31;</td><td>A5-B12-C32;</td><td>A5-B12-C33;</td><td>A5-B12-C34;</td><td>A5-B12-C35;</td><td>A5-B12-C36;</td>
<td>A5-B12-C37;</td><td>A5-B12-C38;</td><td>A5-B12-C39;</td><td>A5-B12-C40;</td><td>A5-B12-C41;</td><td>A5-B12-C42;</td>
<td>A5-B12-C43;</td><td>A5-B12-C44;</td><td>A5-B12-C45;</td><td>A5-B12-C46;</td><td>A6-B12-C1;</td><td>A6-B12-C2;</td>
<td>A6-B12-C3;</td><td>A6-B12-C4;</td><td>A6-B12-C5;</td><td>A6-B12-C6;</td><td>A6-B12-C7;</td><td>A6-B12-C8; </td>
<td>A6-B12-C9;</td><td>A6-B12-C10;</td><td>A6-B12-C11;</td><td>A6-B12-C12;</td><td>A6-B12-C13;</td><td>A6-B12-C14;</td>
<td>A6-B12-C15;</td><td>A6-B12-C16;</td><td>A6-B12-C17;</td><td>A6-B12-C18;</td><td>A6-B12-C19;</td><td>A6-B12-C20;</td>
<td>A6-B12-C21;</td><td>A6-B12-C22;</td><td>A6-B12-C23;</td><td>A6-B12-C24;</td><td>A6-B12-C25;</td><td>A5-B12-C26;</td>
<td>A6-B12-C27;</td><td>A6-B12-C28;</td><td>A6-B12-C29;</td><td>A6-B12-C30;</td><td>A6-B12-C31;</td><td>A6-312-C32;</td>
<td>A6-B12-C33;</td><td>A6-B12-C34;</td><td>A6-B12-C35;</td><td>A6-B12-C36;</td><td>A6-B12-C37;</td><td>A6-B12-C38;</td>
<td>A6-B12-C39;</td><td>A6-B12-C40;</td><td>A6-B12-C41;</td><td>A6-B12-C42;</td><td>A6-B12-C43;</td><td>Ao-B12-C44;</td>
<td>A6-B12-C45;</td><td>A6-B12-C46;</td><td>A7-B12-C1;</td><td>A7-B12-C2;</td><td>A7-B12-C3;</td><td>A7-B12-C4;</td>
<td>A7-B12-C5;</td><td>A7-B12-C6;</td><td>A7-B12-C7;</td><td>A7-B12-C8;</td><td>A7-B12-C9;</td><td>A7-B12-C10;</td>
<td>A7-B12-C11;</td><td>A7-B12-C12;</td><td>A7-B12-C13;</td><td>A7-B12-C14;</td><td>A7-B12-C15;</td><td>A7-B12-C16;</td>
<td>A7-B12-C17;</td><td>A7-B12-C18;</td><td>A7-B12-C19;</td><td>A7-B12-C20;</td><td>A7-B12-C21;</td><td>A7-B12-C22;</td>
<td>A7-B12-C23;</td><td>A7-B12-C24;</td><td>A7-B12-C25;</td><td>A7-B12-C26;</td><td>A7-B12-C27;</td><td>A7-B12-C28;</td>
<td>A7-B12-C29;</td><td>A7-B12-C30;</td><td>A7-B12-C31;</td><td>A7-B12-C32;</td><td>A7-B12-C33;</td><td>A7-B12-C34;</td>
<td>A7-B12-C35;</td><td>A7-B12-C36;</td><td>A7-B12-C37;</td><td>A7-B12-C38;</td><td>A7-B12-C39;</td><td> £7-312-040;</td>
<td>A7-B12-C41;</td><td>A7-B12-C42;</td><td>A7-B12-C43;</td><td>A7-B12-C44;</td><td>A7-B12-C45;</td><td>A7-312-C46;</td>
<td>A8-B12-C1;</td><td>A8-B12-C2;</td><td>A8-B12-C3;</td><td>A8-B12-C4;</td><td>A8-B12-C5;</td><td>A8-312-C6;</td>
<td>A8-B12-C7;</td><td>A8-B12-C8;</td><td>A8-B12-C9;</td><td>A8-B12-C10;</td><td>A8-312-C11;</td><td>A8-312-C12;</td>
<td>A8-B12-C13;</td><td>A8-B12-C14;</td><td>A8-B12-C15;</td><td>A8-B12-C16;</td><td>A8-B12-C17;</td><td>A8-312-C18;</td>
<td>A8-B12-C19;</td><td>A8-B12-C20;</td><td>A8-B12-C21;</td><td>A8-B12-C22;</td><td>A8-B12-C23;</td><td>A3-B12-C24;</td>
<td>A8-B12-C25;</td><td>A8-B12-C26;</td><td>A8-B12-C27;</td><td>A8-B12-C28;</td><td>A8-B12-C29;</td><td>A8-B12-C30;</td>
<td>A8-B12-C31;</td><td>A8-B12-C32;</td><td>A8-B12-C33;'</td><td>A8-B12-C34;</td><td>A8-B12-C35;</td><td>A3-B12-C36;</td>
<td>A8-B12-C37;</td><td>A8-B12-C38;</td><td>A8-B12-C39;</td><td>A8-B12-C40;</td><td>A8-B12-C41;</td><td>A-3-B12-C42;</td>
<td>A8-B12-C43;</td><td>A8-B12-C44';</td><td>A8-B12-C45;</td><td>A8-B12-C46;</td><td>A9-B12-C1;</td><td>A9-B12-C2;</td>
<td>A9-B12-C3;</td><td>A9-B12-C4;</td><td>A9-B12-C5;</td><td>A9-B12-C6;</td><td>A9-B12-C7;</td><td>A9-B12-C8;</td>
<td>A9-B12-C9;</td><td>A9-B12-C10;</td><td>A9-B12-C11;</td><td>A9-B12-C12;</td><td>A9-B12-C13;</td><td>A9-B12-C14;</td>
<td>A9-B12-C15;</td><td>A9-B12-C16;</td><td>A9-B12-C17;</td><td>A9-B12-C18;</td><td>A9-B12-C19;</td><td>A9-B12-C20;</td>
<td>A9-B12-C21;</td><td>A9-B12-C22;</td><td>A9-B12-C23;</td><td>A9-B12-C24;</td><td>A9-B12-C25;</td><td>A9-B12-C26;</td>
<td>A9-B12-C27;</td><td>A9-B12-C28;</td><td>A9-B12-C29;</td><td>A9-B12-C30;</td><td>A9-B12-C31;</td><td>A9-312-C32;</td>
<td>A9-B12-C33;</td><td>A9-B12-C34;</td><td>A9-B12-C35;</td><td>A9-B12-C36;</td><td>A9-B12-C37;</td><td>A9-B12-C38;</td>
<td>A9-B12-C39;</td><td>A9-B12-C40;</td><td>A9-B12-C41;</td><td>A9-B12-C42;</td><td>A9-B12-C43;</td><td>A9-B12-C44;</td>
<td>A9-B12-C45;</td><td>A9-B12-C46;</td><td>A10-B12-C1;</td><td>A10-B12-C2;</td><td>A10-B12-C3;</td><td>A10-B12-C4;</td>
<td>A10-B12-C5;</td><td>A10-B12-C6;</td><td>A10-B12-C7;</td><td>A10-B12-C8;</td><td>A10-B12-C9;</td><td>A10-B12- ΤΊ 'Ί </td>
<td>Α10-Β12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>ú. — t A10-B12-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>Α10-Β12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A1O-B12-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>Α10-Β12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-312-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>Α10-Β12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-B12-</td><td>A10-312-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A11-B12-C1;</td><td>A11-B12-C2;</td><td>A11-B12-C3;</td><td>A11-B12-C4;</td><td>A11-B12-C5;</td><td>A11-312-C6;</td>
<td>A11-B12-C7;</td><td>A11-B12-C8;</td><td>A11-B12-C9;</td><td>A11-B12-</td><td>A11-B12-</td><td>All-312-</td>
<td>Α11-Β12-</td><td>A11-B12-</td><td>A11-B12-</td><td>C1O; A11-B12-</td><td>Cll; A11-B12-</td><td>C12; All-312-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α11-Β12-</td><td>A11-B12-</td><td>A11-B12-</td><td>A11-B12-</td><td>A11-B12-</td><td>All-312-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>Α11-Β12-</td><td>A11-B12-</td><td>A11-B12-</td><td>A11-B12-</td><td>A11-B12-</td><td>All-312-</td>
<td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>Α11-Β12-</td><td>A11-B12-</td><td>ΑΠ-Β12-</td><td>A11-B12-</td><td>A11-B12-</td><td>All-312-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α11-Β12-</td><td>A11-B12-</td><td>A11-B12-</td><td>A11-B12-</td><td>A11-B12-</td><td>All-312-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α11-Β12-</td><td>A11-B12-</td><td>A11-B12-</td><td>A11-B12-</td><td>A12-B12-C1;</td><td>A12-312-C2;</td>
<td>C4 3; A12-B12-C3;</td><td>C4 4; A12-B12-C4;</td><td>C4 5; A12-B12-C5;</td><td>C4 6; A12-B12-C6;</td><td>A12-B12-C7;</td><td>A12-B12-C8;</td>
<td>A12-B12-C9;</td><td>A12-B12-</td><td>A12-B12-</td><td>A12-B12-</td><td>A12-B12-</td><td>Α12-312-</td>
<td>Α12-Β12-</td><td>C10; A12-B12-</td><td>Cll; A12-B12- .</td><td>C12; A12-B12-</td><td>C13; A12-B12-</td><td>C14 ; Α12-Ξ12-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α12-Β12-</td><td>A12-B12-</td><td>A12-B12-</td><td>A12-B12-</td><td>A12-B12-</td><td>Α12-Ξ12-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α12-Β12-</td><td>A12-B12-</td><td>A12-B12-</td><td>A12-B12-</td><td>A12-B12-</td><td>Α12-Ξ12-</td>
<td>C27;</td><td>C2 8;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α12-Β12-</td><td>A12-B12-</td><td>A12-B12-</td><td>A12-B12-</td><td>A12-B12-</td><td>Α12-Ξ12-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>Α12-Β12-</td><td>A12-B12-</td><td>A12-B12-</td><td>AÍ2-B12-</td><td>A12-B12-</td><td>Α12-Ξ12-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α12-Β12- '</td><td>A12-B12-</td><td>A13-B12-C1;</td><td>A13-B12-C2;</td><td>A13-B12-C3;</td><td>A13-312-C4;</td>
<td>C4 5; A13-B12-C5;</td><td>C4 6; A13-B12-C6;</td><td>A13-B12-C7;</td><td>A13-B12-C8;</td><td>A13-B12-C9;</td><td>Α13-Ξ12-</td>
<td>Α13-Β12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>C1O; A13-312-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>Α13-Ξ12-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>Α13-Ξ12-</td>
<td>C2 3;</td><td>C2 4;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C2 8;</td>
<td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>Α13-Ξ12-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A13-B12-</td><td>A13-B12- ’</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>Α13-Ξ12-</td>
<td>C35;</td><td>C36 ;</td><td>C37;</td><td>C38;</td><td>C3 9;</td><td>C4O;</td>
<td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>A13-B12-</td><td>Α13-Ξ12-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A14-B12-C1;</td><td>A14-B12-C2;</td><td>A14-B12-C3;</td><td>A14-B12-C4;</td><td>A14-B12-C5;</td><td>A14-312-C6;</td>
<td>A14-B12-C7;</td><td>A14-B12-C8;</td><td>A14-B12-C9;</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-312-</td>
<td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>C1O; A14-B12-</td><td>Cll; A14-B12-</td><td>C12; A14-312-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-312-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-312-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>Α14-Ξ12-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-312-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α14-Β12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A14-B12-</td><td>A15-B12-C1;</td><td>A15-B12-C2;</td>
<td>C4 3; A15-B12-C3;</td><td>C4 4 ; A15-B12-C4;</td><td>C4 5; A15-B12-C5;</td><td>C4 6; A15-B12-C6;</td><td>A15-B12-C7;</td><td>A15-B12-C8;</td>
<td>A15-B12-C9;</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>Α15-Β12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>Α15-Ξ12-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α15-Β12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12- .</td><td>A15-B12-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C2 5;</td><td>C26;</td>
<td>Α15-Β12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α15-Β12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α15-Β12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>A15-B12-</td><td>Α15-Ξ12-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α15-Β12-</td><td>A15-B12-</td><td>A16-B12-C1;</td><td>A16-B12-C2;</td><td>A16-B12-C3;</td><td>A16-312-C4;</td>
<td>C45; A16-B12-C5;</td><td>C4 6; A16-B12-C6;</td><td>A16-B12-C7;</td><td>A16-B12-C8;</td><td>A16-B12-C9;</td><td>A16-B12-</td>
<td>Α16-Β12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>C1O; A16-B12-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>Α16-Ξ12-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>Α16-Ξ12-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-312-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-5Í2-</td>
<td>C35 ;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>A16-B12-</td><td>Α16-Ξ12-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A17-B12-C1;</td><td>A17-B12-C2;</td><td>A17-B12-C3;</td><td>A17-B12-C4;</td><td>A17-B12-C5;</td><td>A17-312-C6;</td>
<td>A17-B12-C7;</td><td>A17-BÍ2-C8;</td><td>A17-B12-C9;</td><td>A17-B12-</td><td>A17-B12-</td><td>Α17-Ξ12-</td>
<td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>C1O; A17-B12-</td><td>Cll; A17-B12- </td><td>C12; A17-B12-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>Α17-Ξ32-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>AÍ7-B12-</td><td>A17-312-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-312-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>Α17-Ξ12-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A17-B12-</td><td>A18-B12-C1;</td><td>A18-332-C2;</td>
<td>C4 3; A18-B12-C3;</td><td>C4 4; A18-B12-C4';</td><td>C4 5; A18-B12-C5;</td><td>C4 6; A18-B12-C6;</td><td>A18-B12-C7;</td><td>A18-512-C8;</td>
<td>A18-B12-C9;</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-312-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>Α18-Ξ12-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>Á18-B12-</td><td>A18-B12-</td><td>A18-312-</td>
<td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24;</td><td>C2 5;</td><td>C2 6;</td>
<td>A18-B12-</td><td>A1S-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-312-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-312-</td>
<td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A1S-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-B12-</td><td>A18-312-</td>
<td>C3 9;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A18-B12-</td><td>A18-B12-</td><td>A19-B12-C1;</td><td>A19-B12-C2;</td><td>A19-B12-C3;</td><td>A19-312-C4;</td>
<td>C4 5; A19-B12-C5;</td><td>C4 6; A19-B12-C6;</td><td>A19-B12-C7;</td><td>A19-B12-C8;</td><td>A19-B12-C9;</td><td>A19-312-</td>
C10;
<td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td><td>A19-B12-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A20-B12-C1;</td><td>A20-B12-C2;</td><td>A20-B12-C3;</td><td>A20-B12-C4;</td><td>A20-B12-C5;</td><td>A20-B12-C6;</td>
<td>A20-B12-C7;</td><td>A20-B12-C8;</td><td>A20-B12-C9;</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-E12-</td>
<td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>C1O; A20-B12-</td><td>Cll; A20-B12-</td><td>C12; A20-B12-</td>
<td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>Č2 4;</td>
<td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B32-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-E32-</td>
<td>C37;</td><td>C38;</td><td>. C39;</td><td>C4O;</td><td>C41;</td><td>C4 2·;</td>
<td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A20-B12-</td><td>A21-B12-C1;</td><td>A21-B12-C2;</td>
<td>C4 3; A21-B12-C3;</td><td>C4 4 ; A21-B12-C4;</td><td>C4 5; A21-B12-C5;</td><td>C4 6; A21-B12-C6;</td><td>A21-B12-C7;</td><td>A21-B12-C8;</td>
<td>A21-B12-C9;</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B32-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-E'32-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B32-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td><td>A21-B12-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A21-B12-</td><td>A21-B12-</td><td>A22-B12-C1;</td><td>A22-B12-C2;</td><td>A22-B12-C3;</td><td>A22-B32-C4;</td>
<td>C4 5; A22-B12-C5;</td><td>C4 6; A22-B12-C6;</td><td>A22-B12-C7;</td><td>A22-B12-C8;</td><td>A22-B12-C9;</td><td>Α22-Ξ32-</td>
<td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>C1O; A22-B12-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A22-B12-</td><td>A22-B12- '</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-E12-</td>
<td>C17;</td><td>C18;</td><td>C19; ·</td><td>C2O;</td><td>C21;</td><td>C22;</td>
<td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-BL2-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>Α22-Ξ12-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B32-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-B12-</td><td>A22-BL2-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A23-B12-C1;</td><td>A23-B12-C2;</td><td>A23-B12-C3;</td><td>A23-B12-C4;</td><td>A23-B12-C5;</td><td>A23-B32-C6;</td>
<td>A23-B12-C7;</td><td>A23-B12-C8;</td><td>A23-B12-C9;</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td>
<td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>C1O; A23-B12-</td><td>Cll; A23-B12-</td><td>C12; A23-B12-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A23-312-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>Α23-Ξ12-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>Α23-Β12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C3O;</td>
<td>Α23-Β12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td>
<td>Α23-Β12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α23-Β12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A23-B12-</td><td>A24-B12-C1;</td><td>A24-B12-C2;</td>
<td>C4 3; A24-B12-C3;</td><td>C4 4 ; A24-B12-C4;</td><td>C4 5; A24-B12-C5;</td><td>C4 6; A24-B12-C6;</td><td>A24-B12-C7;</td><td>A24-B12-C8;</td>
<td>A24-B12-C9;</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>Α24-Β12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α24-Β12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td><td>C25;</td><td>C2 6;</td>
<td>Α24-Β12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C3l·;</td><td>C32;</td>
<td>Α24-Β12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α24-Β12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td><td>A24-B12-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C42;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α24-Β12-</td><td>A24-B12-</td><td>A25-B12-C1;</td><td>A25-B12-C2;</td><td>A25-B12-C3;</td><td>A25-B12-C4;</td>
<td>C4 5; A25-B12-C5;</td><td>C4 6; A25-B12-C6;</td><td>A25-B12-C7;</td><td>A25-B12-C8;</td><td>A25-B12-C9;</td><td>A25-B12-</td>
<td>Α25-Β12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>C1C; A25-B12-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-E12-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-312-</td>
<td>C2 3;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>Α2Ξ-Β12-</td><td>Α2Ξ-Β12-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33 ;</td><td>C34;</td>
<td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>.A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td><td>A25-B12-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A26-B12-C1;</td><td>A26-B12-C2;</td><td>A26-B12-C3;</td><td>A26-B12-C4;</td><td>A26-B12-C5;</td><td>A26-3L2-C6;</td>
<td>A26-B12-C7;</td><td>A26-B12-C8;</td><td>A26-B12-C9;</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td>
<td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>C1O; A26-B12-</td><td>Cll; A26-B12-</td><td>C12; A26-BL2-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C13;</td>
<td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A26-B12-</td><td>A26-B12-</td><td>A26-312-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-312-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-BLŽ-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A26-B12-</td><td>A26-B12- .</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A26-B12-</td><td>A27-B12-C1;</td><td>A27-B12-C2;</td>
<td>C4 3; A27-B12-C3;</td><td>C4 4; A27-B12-C4;</td><td>C4 5; A27-B12-C5;</td><td>C4 6; A27-B12-C6;</td><td>A27-B12-C7;</td><td>A27-B12-C8;</td>
<td>A27-B12-C9;</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-Bľ2-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-BL2-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td>
<td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α27-Β12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td><td>A27-B12-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α27-Β12-</td><td>A27-B12-</td><td>A28-B12-C1;</td><td>A28-B12-C2;</td><td>A28-B12-C3;</td><td>A28-B12-C4;</td>
<td>C4 5; A28-B12-C5;</td><td>C4 6; A28-B12-C6;</td><td>A28-B12-C7;</td><td>A28-B12-C8;</td><td>A28-B12-C9;</td><td>A28-B12-</td>
<td>Α28-Β12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>C10; A28-B12-</td>
<td>Cll ;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td><td>A28-B12-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A1-B13-C1;</td><td>A1-B13-C2;</td><td>A1-B13-C3;</td><td>A1-B13-C4;</td><td>A1-B13-C5;</td><td>A1-B13-C6;</td>
<td>A1-B13-C7;</td><td>A1-B13-C8;</td><td>A1-B13-C9;</td><td>A1-B13-C10;</td><td>A1-B13-C11;</td><td>A1-B13-C12;</td>
<td>A1-B13-C13;</td><td>A1-B13-C14;</td><td>AL-B13-C15;</td><td>A1-B13-C16;</td><td>A1-B13-C17;</td><td>A1-B13-C18;</td>
<td>A1-B13-C19;</td><td>A1-B13-C20;</td><td>A1-B13-C21;</td><td>A1-B13-C22;</td><td>A1-B13-C23;</td><td>A1-B13-C24;</td>
<td>A1-B13-C25;</td><td>A1-B13-C26;</td><td>A1-B13-C27;</td><td>A1-B13-C28;</td><td>A1-B13-C29;</td><td>A1-B13-C30;</td>
<td>A1-B13-C31;</td><td>A1-B13-C32;</td><td>A1-B13-C33;</td><td>A1-B13-C34;</td><td>A1-B13-C35;</td><td>A1-B13-C36;</td>
<td>A1-B13-C37;</td><td>A1-B13-C38;</td><td>A1-B13-C39;</td><td>A1-B13-C40;</td><td>A1-B13-C41;</td><td>. A1-B13-C42;</td>
<td>A1-BÍ3-C43;</td><td>A1-B13-C44;</td><td>A1-B13-C45;</td><td>A1-B13-C46;</td><td>A2-B13-C1;</td><td>A2-B13-C2;</td>
<td>A2-B13-C3;</td><td>A2-B13-C4;</td><td>A2-B13-C5;</td><td>A2-B13-C6;</td><td>A2-B13-C7;</td><td>A2-B13-C8;</td>
<td>A2-B13-C9;</td><td>A2-B13-C10;</td><td>A2-B13-C11;</td><td>A2-B13-C12;</td><td>A2-B13-C13;</td><td>A2-B13-C14;</td>
<td>A2-B13-C15;</td><td>A2-B13-C16;</td><td>A2-B13-C17;</td><td>A2-B13-C18;</td><td>A2-B13-C19;</td><td>A2-B13-C20;</td>
<td>A2-B13-C21;</td><td>A2-B13-C22;</td><td>A2-B13-C23;</td><td>A2-B13-C24;</td><td>A2-B13-C25;</td><td>A2-B13-C26;</td>
<td>A2-B13-C27;</td><td>A2-B13-C28;</td><td>A2-B13-C29;</td><td>A2-B13-C30;</td><td>A2-B13-C31;</td><td>A2-B13-C32;</td>
<td>A2-B13-C33;</td><td>A2-B13-C34;</td><td>A2-B13-C35;</td><td>A2-B13-C36;</td><td>A2-B13-C37;</td><td>A2-B13-C38;</td>
<td>A2-B13-C39;</td><td>A2-B13-C40;</td><td>A2-B13-C41;</td><td>A2-B13-C42;</td><td>A2-B13-C43;</td><td>A2-B13-C44;</td>
<td>A2-B13-C45;</td><td>A2-B13-C46;</td><td> A3-B13-C1;</td><td>A3-B13-C2; '</td><td>A3-B13-C3;</td><td>A3-B13-C4.;</td>
<td>A3-B13-C5;</td><td>A3-B13-C6;</td><td>A3-B13-C7;</td><td>A3-B13-C8;</td><td>A3-B13-C9;</td><td>A3-B13-C10;</td>
<td>A3-B13-C11 ;</td><td>A3-B13-C12;</td><td>A3-B13-C13;</td><td>A3-B13-C14;</td><td>A3-B13-C15;</td><td>A3-B13-C16;</td>
<td>A3-B13-C17 ;</td><td>A3-B13-C18;</td><td>A3-B13-C19;</td><td>A3-B13-C20;</td><td>A3-B13-C21;</td><td>A3-B13-C22;</td>
<td>A3-B13-C23;</td><td>A3-B13-C24;</td><td>A3-B13-C25;</td><td>A3-B13-C26;</td><td>A3-B13-C27;</td><td>A3-B13-C28;</td>
<td>A3-B13-C29;</td><td>A3-B13-C30;</td><td>A3-B13-C31;</td><td>A3-B13-C32;</td><td>A3-B13-C33;</td><td>A3-B13-C34;</td>
<td>A3-B13-C35;</td><td>A3-B13-C36;</td><td>A3-B13-C37;</td><td>A3-B13-C38;</td><td>A3-B13-C39;</td><td>A3-B13-C40;</td>
<td>A3-B13-C41;</td><td>A3-B13-C42;</td><td>A3-B13-C43;</td><td>A3-B13-C44;</td><td>A3-B13-C45;</td><td>A3-B13-C46;</td>
<td>A4-B13-C1;</td><td>A4-B13-C2;</td><td>A4-B13-C3;</td><td>A4-B13-C4;</td><td>A4-B13-C5;</td><td>A4-B13-C6;</td>
<td>A4-B13-C7;</td><td>A4-B13-C8;</td><td>A4-B13-C9;·</td><td>A4-B13-C10;</td><td>A4-B13-C11;</td><td>A4-B13-C12;</td>
<td>A4-B13-C13;</td><td>A4-B13-C14;</td><td>A4-B13-C15;</td><td>A4-B13-C16;</td><td>A4-B13-C17;</td><td>A4-B13-C18;</td>
<td>A4-B13-C19;</td><td>A4-B13-C20;</td><td>A4-B13-C21;</td><td>A4-B13-C22;</td><td>A4-B13-C23;</td><td>A4-B13-C24;</td>
<td>A4-B13-C25;</td><td>A4-B13-C26;</td><td>A4-B13-C27;</td><td>A4-B13-C28;</td><td>A4-B13-C29;</td><td>A4-B13-C30;</td>
<td>A4-B13-C31;</td><td>A4-B13-C32;</td><td>A4-B13-C33;</td><td>A4-B13-C34;</td><td>A4-B13-C35;</td><td>A4-B13-C36;</td>
<td>A4-B13-C37;</td><td>A4-B13-C38;</td><td>A4-B13-C39;</td><td>A4-B13-C40;</td><td>A4-B13-C41;</td><td>A4-B13-C42;</td>
<td>A4-B13-C43;</td><td>A4-B13-C44;</td><td>A4-B13-C45;</td><td>A4-B13-C46;</td><td>A5-B13-C1;</td><td>A5-B13-C2;</td>
<td>A5-B13-C3;</td><td>A5-B13-C4;</td><td>A5-B13-C5;</td><td>A5-B13-C6;</td><td>A5-B13-C7;</td><td>A5-B13-C8;</td>
<td>A5-B13-C9;</td><td>A5-B13-C10;</td><td>A5-B13-C11;</td><td>A5-B13-C12;</td><td>A5-B13-C13;</td><td>A5-B13-C14;</td>
<td>A5-B13-C15;</td><td>A5-B13-C16;</td><td>A5-B13-C17;</td><td>A5-B13-C18;</td><td>A5-B13-C19;</td><td>A5-B13-C20;</td>
<td>A5-B13-C21;</td><td>A5-B13-C22;</td><td>A5-B13-C23;</td><td>A5-B13-C24;</td><td>A5-B13-C25;</td><td>A5-B13-C26;</td>
<td>A5-B13-C27;</td><td>A5-B13-C28;</td><td>A5-B13-C29;</td><td>A5-B13-C30;</td><td>A5-B13-C31;</td><td>A5-B13-C32;</td>
<td>A5-B13-C33;</td><td>A5-B13-C34;</td><td>A5-B13-C35;</td><td>A5-B13-C36;</td><td>A5-B13-C37;</td><td>A5-B13-C38;</td>
<td>A5-B13-C39;</td><td>A5-B13-C40;</td><td>A5-B13-C41;</td><td>A5-B13-C42;</td><td>A5-B13-C43;</td><td>A5-B13-C44;</td>
<td>A5-B13-C45;</td><td>A5-B13-C46;</td><td>A6-B13-C1;</td><td>A6-B13-C2;</td><td>A6-B13-C3;</td><td>A6-B13-C4;</td>
<td>A6-B13-C5;</td><td>A6-B13-C6;</td><td>A6-B13-C7;</td><td>A6-B13-C8;</td><td>A6-B13-C9;</td><td>A6-B13-C10;</td>
<td>A6-B13-C11;</td><td>A6-B13-C12;</td><td>A6-B13-C13;</td><td>A6-B13-C14;</td><td>A6-B13-C15;</td><td>A6-B13-C16;</td>
<td>A6-B13-C17;</td><td>A6-B13-C18;</td><td>A6-B13-C19;</td><td>A6-B13-C20;</td><td>A6-B13-C21;</td><td>A6-B13-C22;</td>
<td>A6-B13-C23;</td><td>A6-B13-C24;</td><td>A6-B13-C25;</td><td>A6-B13-C26;</td><td>A6-B13-C27;</td><td>A6-B13-C28;</td>
<td>A6-B13-C29;</td><td>A6-B13-C30;</td><td>AÔ-B13-C31;</td><td>A6-B13-C32;</td><td>A6-B13-C33;</td><td>A6-B13-C34;</td>
<td>A6-B13-C35;</td><td>A6-B13-C36;</td><td>A6-B13-C37;</td><td>A6-B13-C38;</td><td>A6-B13-C39;</td><td>A6-B13-C40;</td>
<td>A6-B13-C41;</td><td>A6-B13-C42;</td><td>A6-B13-C43;</td><td>A6-B13-C44;</td><td>A6-B13-C45;</td><td>A6-B13-C46;</td>
<td>A7-B13-C1;</td><td>A7-B13-C2;</td><td>A7-B13-C3;</td><td>A7-B13-C4;</td><td>A7-B13-C5;</td><td>A7-B13-C6;</td>
<td>A7-B13-C7;</td><td>A7-B13-C8;</td><td>A7-B13-C9;</td><td>A7-B13-C10;</td><td>A7-B13-C11;</td><td>A7-B13-C12;</td>
<td>A7-B13-C13;</td><td>A7-B13-C14;</td><td>A7-B13-C15;</td><td>A7-B13-C16;</td><td>A7-B13-C17;</td><td>A7-B13-C18;</td>
<td>A7-B13-C19;</td><td>A7-B13-C20;</td><td>A7-B13-C21;</td><td>A7-B13-C22;</td><td>A7-B13-C23;</td><td>A7-B13-C24;</td>
<td>A7-B13-C25;</td><td>A7-B13-C26;</td><td>A7-B13-C27;</td><td>A7-B13-C28;</td><td>A7-B13-C29;</td><td>A7-B13-C30;</td>
<td>A7-B13-C31;</td><td>A7-B13-C32;</td><td>A7-B13-C33;</td><td>A7-B13-C34;</td><td>A7-B13-C35;</td><td>A7-B13-C36;</td>
<td>A7-B13-C37;</td><td>A7-B13-C38;</td><td>A7-B13-C39;</td><td>A7-B13-C40;</td><td>A7-B13-C41;</td><td>A7-B13-C42;</td>
<td>A7-B13-C43;</td><td>A7-B13-C44;</td><td>A7-B13-C45;</td><td>A7-B13-C46;</td><td>A8-B13-C1;</td><td>A8-B13-C2;</td>
<td>A8-B13-C3;</td><td>A8-B13-C4;</td><td>A8-313-C5;</td><td>A8-B13-C6;</td><td>A8-B13-C7;</td><td>A8-B13-C8;</td>
<td>A8-B13-C9;</td><td>A8-B13-C10;</td><td>A8-313-C11;</td><td>A8-B13-C.12;</td><td>A8-B13-C13;</td><td>A8-B13-C14;</td>
<td>A8-B13-C15;</td><td>A8-B13-C16;</td><td>A8-B13-C17;</td><td>A8-B13-C18;</td><td>A8-B13-C19;</td><td>A8-B13-C20;</td>
<td>A8-B13-C21;</td><td>A8-B13-C22;</td><td>A8-313-C23;</td><td>A8-B13-C24;</td><td>A8-B13-C25;</td><td>A8-B13-C26;</td>
<td>A8-B13-C27;</td><td>A8-B13-C28;</td><td>A8-313-C29;</td><td>A8-313-C30;</td><td>A8-B13-C31;</td><td>A8-B13-C32;</td>
<td>A8-B13-C33;</td><td>A8-B13-C34;</td><td>A8-B13-C35;</td><td>A8-B13-C36;</td><td>A8-B13-C37;</td><td>A8-B13-C38;</td>
<td>A8-B13-C39;</td><td>A8-B13-C40;</td><td>A8-B13-C41;</td><td>A8-B13-C42;</td><td>A8-B13-C43;</td><td>A8-B13-C44;</td>
<td>A8-B13-C45;</td><td>A8-B13-C46;</td><td>A9-313-C1;</td><td>A9-B13-C2;</td><td>A9-B13-C3;</td><td>A9-B13-C4;</td>
<td>A9-B13-C5;</td><td>A9-B13-C6;</td><td>A9-B13-C7;</td><td>A9-B13-C8;</td><td>A9-B13-C9;</td><td>A9-B13-C10;</td>
<td>A9-B13-C11;</td><td>A9-B13-C12;</td><td>A9-313-C13;</td><td>A9-B13-C14;</td><td>A9-B13-C15;</td><td>Α9-Β13-Ο16;</td>
<td>A9-B13-C17;</td><td>A9-B13-C18;</td><td>A9-B13-C19;</td><td>A9-B13-C20;</td><td>A9-B13-C21;</td><td>A9-313-C22;</td>
<td>A9-B13-C23;</td><td>A9-B13-C24;</td><td>A9-B13-C25;</td><td>A9-B13-C26;</td><td>A9-B13-C27;</td><td>A9-B13-C28;</td>
<td>A9-B13-C29;</td><td>A9-B13-C30;</td><td>A9-313-C31;</td><td>A9-B13-C32;</td><td>A9-B13-C33;</td><td>A9-313-C34;</td>
<td>A9-B13-C35;</td><td>A9-B13-C36;</td><td>A9-B13-C37;</td><td>A9-BI3-C38;</td><td>A9-B13-C39;</td><td>A9-B13-C40;</td>
<td>A9-B13-C41;</td><td>A9-B13-C42;</td><td>A9-B13-C43;</td><td>A9-B13-C44;</td><td>A9-B13-C45;</td><td>A9-B13-C46;</td>
<td>A10-B13-C1;</td><td>A10-B13-C2;</td><td>A10-B13-C3;</td><td>A10-B13-C4;·</td><td>A10-B13-C5;</td><td>A10-B13-C6;</td>
<td>A10-B13-C7;</td><td>A10-B13-C8;</td><td>A10-B13-C9;</td><td>A10-B13-</td><td>A10-B13-</td><td>A1O-E13-</td>
<td>Α10-Β13-</td><td>A10-B13-</td><td>A10-B13-</td><td>C1O; A10-B13-</td><td>Cll; A10-B13-</td><td>C12; A10-B13-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α10-Β13-</td><td>A10-B13-</td><td>A10-B13-</td><td>A10-B13-</td><td>A10-B13-</td><td>A10-B13-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>Α10-Β13-</td><td>A10-B13-</td><td>A10-313-</td><td>A10-B13-</td><td>A10-B13-</td><td>A10-513-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α10-Β13-</td><td>A10-B13-</td><td>A10-B13-</td><td>A10-B13-</td><td>A10-B13-</td><td>A10-313-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>Α10-Β13-</td><td>A10-B13-</td><td>A10-313-</td><td>A10-B13-</td><td>A10-B13-</td><td>Α10-Ξ13-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α10-Β13-</td><td>A10-B13-</td><td>A10-B13-</td><td>A10-B13-</td><td>A11-B13-C1;</td><td>A11-E13-C2;</td>
<td>C4 3; A11-B13-C3;</td><td>C4 4; A11-B13-C4;</td><td>C4 5; A11-313-C5;</td><td>C4 6; A11-B13-C6;</td><td>A11-B13-C7;</td><td>A11-B13-C8;</td>
<td>A11-B13-C9;</td><td>A11-B13-</td><td>A11-B13-</td><td>All-313-</td><td>A11-B13-</td><td>A11-B13-</td>
<td>Α11-Β13-</td><td>C10; A11-B13-</td><td>Cll; A11-B13-</td><td>C12; A11-B13-</td><td>C13; A11-B13-</td><td>C14; A11-B13-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α11-Β13-</td><td>A11-B13-</td><td>All-313-</td><td>A11-B13-</td><td>A11-B13-</td><td>All-313-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α11-Β13-</td><td>A11-B13-</td><td>Α11-Ξ13-</td><td>A11-B13-</td><td>A11-B13-</td><td>A11-B13-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α11-Β13-</td><td>A11-B13-</td><td>All-313-</td><td>A11-B13-</td><td>A11-B13-</td><td>A11-B13-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α11-Β13-</td><td>A11-B13-</td><td>A11-B13-</td><td>A11-B13-</td><td>A11-B13-</td><td>All-313-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α11-Β13-</td><td>A11-B13-</td><td>A12-313-C1;</td><td>A12-B13-C2;</td><td>A12-B13-C3;</td><td>A12-313-C4;</td>
<td>C4 5; A12-B13-C5;</td><td>C4 6; A12-B13-C6;</td><td>A12-B13-C7;</td><td>A12-B13-C8;</td><td>A12-B13-C9;</td><td>A12-B13-</td>
<td>Α12-Β13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>C1O; A12-313-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-313-</td><td>A12-B13-</td><td>A12-B13-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>Α12-Β13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>Α12-Β13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td>
<td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>Α12-Β13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td><td>A12-B13-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A13-B13-C1;</td><td>A13-B13-C2;</td><td>A13-B13-C3;</td><td>A13-B13-C4;</td><td>A13-B13-C5;</td><td>A13-B13-C6;</td>
<td>A13-B13-C7;</td><td>A13-B13-C8;</td><td>A13-B13-C9;</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td>
<td>Α13-Β13-</td><td>A13-B13-</td><td>, A13-B13-</td><td>C1O; A13-B13-</td><td>Cll; A13-B13-</td><td>C12; A13-B13-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α13-Β13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>Α13-Β13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α13-Β13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α13-Β13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α13-Β13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A13-B13-</td><td>A14-B13-C1;</td><td>A14-B13-C2;</td>
<td>C4 3; A14-B13-C3;</td><td>C4 4 ; A14-B13-C4;</td><td>C4 5 ; A14-B13-C5;</td><td>C4 6; A14-B13-C6;</td><td>A14-B13-C7;</td><td>A14-B13-C8;</td>
<td>A14-B13-C9;</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td>
<td>Α14-Β13-</td><td>C10; A14-B13-</td><td>Cll; A14-B13-</td><td>C12; A14-B13-</td><td>C13; A14-B13-</td><td>C14; A14-B13-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α14-Β13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-E13-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td><td>C25;</td><td>C2 6;</td>
<td>Α14-Β13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-'</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α14-Β13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>Α14-Β13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td><td>A14-B13-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α14-Β13-</td><td>A14-B13- </td><td>Aľ5-B13-Cl;</td><td>A15-B13-C2;</td><td>A15-B13-C3;</td><td>A15-B13-C4;</td>
<td>C4 5; A15-B13-C5;</td><td>C4 6; A15-B13-C6;</td><td>A15-B13-C7;</td><td>A15-B13-C8;</td><td>A15-B13-C9;</td><td>A15-B13-</td>
<td>Α15-Β13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>C1O; A15-B13-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td>
<td>CI7;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td>
<td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>Α15-ΒΊ3-</td><td>A15-B13-</td><td>A15-B13-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td><td>A15-B13-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A16-B13-C1;</td><td>A16-B13-C2;</td><td>A16-B13-C3;</td><td>A16-B13-C4;</td><td>A16-B13-C5;</td><td>A16-B13-C6;</td>
<td>A16-B13-C7;</td><td>A16-B13-C8;</td><td>A16-B13-C9;</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td>
<td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>C1O; A16-B13-</td><td>Cll; A16-B13-</td><td>C12; A16-B13-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
100
<td>Α16-Β13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A16-B13-</td><td>A17-B13-C1;</td><td>A17-B13-C2;</td>
<td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
<td>A17-B13-C3;</td><td>A17-B13-C4;</td><td>A17-B13-C5;</td><td>A17-B13-C6;</td><td>A17-B13-C7;</td><td>A17-B13-C8;</td>
<td>A17-B13-C9;</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>Α17-Β13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α17-Β13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α17-Β13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α17-Β13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α17-Β13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td><td>A17-B13-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α17-Β13-</td><td>A17-B13-</td><td>A18-B13-C1;</td><td>A18-B13-C2;</td><td>A18-B13-C3;</td><td>A18-B13-C4;</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td>
<td>A18-B13-C5;</td><td>A18-B13-C6;</td><td>A18-B13-C7;</td><td>A18-B13-C8;</td><td>A18-B13-C9;</td><td>A18-B13- C10;</td>
<td>Α18-Β13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td>
<td>C23;</td><td>C2 4;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td><td>A18-B13-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ,-</td><td>C4 5;</td><td>C4 6;</td>
<td>A19-B13-C1;</td><td>A19-B13-C2;</td><td>A19-B13-C3;</td><td>ΑΙ 9—BI 3—C4 ;</td><td>A19-B13-C5;</td><td>A19-B13-C6;</td>
<td>A19-B13-C7;</td><td>A19-B13-C8;</td><td>A19-B13-C9;</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td>
<td></td><td></td><td></td><td>C10;</td><td>Cll;</td><td>C12;</td>
<td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C2 3;</td><td>C2 4 ;</td>
<td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A19-B13-</td><td>A20-B13-C1;</td><td>A20-B13-C2;</td>
<td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
<td>A20-B13-C3;</td><td>A20-B13-C4;</td><td>A20-B13-C5;</td><td>A20-B13-C6;</td><td>A20-B13-C7;</td><td>A20-B13-C8;</td>
<td>A20-B13-C9;</td><td>A20-313- </td><td>A20-B13--</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A20-B13-</td><td>A20-313-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C2 5;</td><td>C2 6;</td>
<td>A20-B13-</td><td>A20-313-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A2O-B13-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td><td>A20-B13-</td>
<td>C3 9;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A20-B13-</td><td>A20-B13-</td><td>A21-B13-C1;</td><td>A21-B13-C2;</td><td>A21-B13-C3;</td><td>A21-B13-C4;</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td>
<td>A21-B13-C5;</td><td>A21-B13-C6;</td><td>A21-B13-C7;</td><td>A21-B13-C8;</td><td>A21-B13-C9;</td><td>A21-B13- C10;</td>
101
<td>Α21-Β13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td>
<td>C2 9;</td><td>C3O;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A21-B13-</td><td>A21-313-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td>
<td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td><td>A21-B13-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A22-B13-C1;</td><td>A22-B13-C2;</td><td>A22-B13-C3;</td><td>A22-B13-C4;</td><td>A22-B13-C5;</td><td>A22-B13-C6;</td>
<td>A22-B13-C7;</td><td>A22-313-C8;</td><td>A22-B13-C9;</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td>
<td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>C10; A22-B13-</td><td>Cll; A22-B13-</td><td>C12; A22-B13-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C2 3;</td><td>C2 4 ;</td>
<td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td>
<td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A22-B13-</td><td>A23-B13-C1;</td><td>A23-B13-C2;</td>
<td>C4 3; A23-B13-C3;</td><td>C4 4; A23-B13-C4;</td><td>C4 5; A23-B13-C5;</td><td>C4 6; A23-B13-C6;</td><td>A23-B13-C7;</td><td>A.23-B13-C8;</td>
<td>A23-B13-C9;</td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A23-B13-</td><td>A23-B13-</td><td>A23-E13-</td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A23-B13-</td><td>A23-313-</td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C2 5;</td><td>C2 6;</td>
<td>A23-B13- </td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td><td>' A23-B13-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A23-B13-</td><td>A23-B13-</td><td>A23-E13-</td><td>A23-B13-</td><td>A23-B13-</td><td>A23-B13-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A23-B13-</td><td>A23-313-</td><td>A23-EI3-</td><td>A23-B13-</td><td>A23-B13-</td><td>Ά23-Β13-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A23-B13-</td><td>A23-B13-</td><td>A24-B13-C1;</td><td>A24-B13-C2;</td><td>A24-B13-C3;</td><td>A24-B13-C4;</td>
<td>C4 5; A24-B13-C5;</td><td>C4 6; A24-B13-C6;</td><td>A24-E13-C7;</td><td>A24-B13-C8;</td><td>A24-B13-C9;</td><td rowspan="2">A24-B13- C10; A24-B13-</td>
<td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A24-B13-</td><td>A24-313-</td><td>A24-B13-</td><td>Ά24-Β13-</td><td>A24-B13-</td><td>Ά24-Β13-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21 ;</td><td>C22;</td>
<td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A24-B13-</td><td>A24-313-</td><td>A24-E13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td>
<td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td><td>A24-B13-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A25-B13-C1;</td><td>A25-B13-C2;</td><td>A25-B13-C3;</td><td>A25-B13-C4;</td><td>A25-B13-C5;</td><td>A25-B13-C6;</td>
<td>A25-B13-C7;</td><td>A25-B13-C8;</td><td>A25-B13-C9;</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td>
<td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>C10; A25-B13-</td><td>Cll; A25-B13-</td><td>C12; A25-B13-</td>
<td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A25-B13-</td><td>A25-313-</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
102
Α25-Β13C25;
Α25-Β13C31;
Α25-Β13C37;
Α25-Β13C4 3;
A26-B13-C3;
A26-B13-C9;
Α26-Β13C15;
Α26-Β13C21;
Α26-Β13C27;
Α26-Β13C33;
Α26-Β13C39;
Α26-Β13C4 5;
A27-B13-C5;
Α27-Β13Cll;
A27-B13C17;
A27-B13C23;
A27-B13C2 9;
A27-B13C35;
A27-B13C41;
A28-B13-C1;
A28-B13-C7;
A28-B13C13;
A28-B13C19;
A28-B13C25;
A28-B13C31;·
A28-B13C37;
A28-B13C4 3;
A1-B14-C3;
A1-B14-C9;
A1-B14-C15;
A1-B14-C21;
A1-B14-C27;
A1-B14-C33;
A1-B14-C39;
A1-B14-C45;
A2-B14-C5;
A2-B14-C11;
A2-B14-C17;
<td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td>
<td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td>
<td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td>
<td>C38;</td><td>C3 9;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A25-B13-</td><td>A25-B13-</td><td>A25-B13-</td><td>A26-B13-C1;</td><td>A26-B13-C2;</td>
<td>C4 4; .</td><td>C45;</td><td>C4 6;</td><td></td><td></td>
<td>A26-B13-C4;</td><td>A26-B13-C5;</td><td>A26-B13-C6;</td><td>A26-B13-C7;</td><td>A26-B13-C8;</td>
<td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-’</td>
<td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>Α26-Ξ13-</td>
<td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td>
<td>C22;</td><td>C23;</td><td>C24;</td><td>C2 5;</td><td>C2 6;</td>
<td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td>
<td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-E13-</td>
<td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td><td>A26-B13-</td>
<td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>A26-B13-</td><td>A27-B13-C1;</td><td>A27-B13-C2;</td><td>A27-B13-C3;</td><td>A27-B13-C4;</td>
<td>C4 6;</td><td></td><td></td><td></td><td></td>
<td>A27-B13-C6;</td><td>A27-B13-C7;</td><td>A27-B13-C8;</td><td>A27-B13-C9;</td><td>A27-B13-</td>
<td></td><td></td><td></td><td></td><td>C10;</td>
<td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td>
<td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td>
<td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>Α27-Ξ13-</td>
<td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C2 8;</td>
<td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-E13-</td>
<td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>Α27-Ξ13-</td>
<td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>A27-B13-</td><td>Α27-Ξ13·-</td>
<td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A28-B13-C2;</td><td>A28-B13-C3;</td><td>A28-B13-C4;</td><td>A28-B13-C5;</td><td>A28-E13-C6;</td>
<td>A28-B13-C8;</td><td>A28-B13-C9;</td><td>A28-B13-</td><td>A28-B13-</td><td>Α28-Ξ13-</td>
<td></td><td></td><td>C10;</td><td>Cll;</td><td>C12;</td>
<td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td>
<td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>Α28-Ξ13-</td>
<td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td>
<td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A28-E13-</td>
<td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A2S-B13-</td>
<td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A28-B13-</td><td>A28-B13-</td><td>A28-B13-</td><td>A1-B14-C1;</td><td>A1-B1.-C2;</td>
<td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
<td>A1-B14-C4;</td><td>A1-B14-C5;</td><td>A1-B14-C6;</td><td>A1-B14-C7;</td><td>A1-B14-C8;</td>
<td>A1-B14-C10;</td><td>A1-B14-C11;</td><td>A1-B14-C12;</td><td>A1-B14-C13;</td><td>A1-B14-C14;</td>
<td>A1-B14-C16;</td><td>A1-B14-C17;</td><td>A1-B14-C18;</td><td>A1-B14-C19;</td><td>A1-B14-C20;</td>
<td>A1-B14-C22;</td><td>A1-B14-C23;</td><td>A1-B14-C24;</td><td>A1-B14-C25;</td><td>A1-B14-C25;</td>
<td>A1-B14-C28;</td><td>A1-B14-C29;</td><td>A1-B14-C30;</td><td>A1-B14-C31;</td><td>A1-B14-C32;</td>
<td>A1-B14-C34;</td><td>A1-B14-C35;</td><td>A1-B14-C36;</td><td>A1-B14-C37;</td><td>A1-B14-C38;</td>
<td>A1-B14-C40;</td><td>A1-B14-C41;</td><td>A1-B14-C42;</td><td>A1-B14-C43;</td><td>A1-B14-C44;</td>
<td>A1-B14-C46;</td><td>A2-B14-C1;</td><td>A2-B14-C2;</td><td>A2-B14-C3;</td><td>A2-B14-C4;</td>
<td>A2-B14-C6;</td><td>A2-B14-C7;</td><td>A2-B14-C8;</td><td>A2-B14-C9;</td><td>A2-B14-C10;</td>
<td>A2-B14-C12;</td><td>A2-B14-C13;</td><td>A2-B14-C14;</td><td>A2-B14-C15;</td><td>A2-B14-C16;</td>
<td>A2-B14-C18;</td><td>A2-B14-C19;</td><td>A2-B14-C20;</td><td>A2-B14-C21;</td><td>A2-B14-C22;</td>
103
A2-B14-C23;
A2-B14-C29;
A2-B14-C35;
A2-B14-C41;
A3-B14-C1;
A3-B14-C7;
A3-B14-C13;
A3-B14-C19;
A3-B14-C25;
A3-B14-C31;
A3-B14-C37;
A3-B14-C43;
A4-B14-C3;
A4-B14-C9;
A4-B14-C15;
A4-B14-C21;
A4-B14-C27;
A4-B14-C33;
A4-B14-C39;
A4-B14-C45;
A5-B14-C5;
A5-B14-C11;
A5-B14-C17;
A5-B14-C23;
A5-B14-C29;
A5-B14-C35;
A5-B14-C41;
A6-B14-C1;
A6-B14-C7;
A6-B14-C13;
A6-B14-C19;
A6-B14-C25;
A6-B14-C31;
A6-B14-C37;
A6-B14-C43;
A7-B14-C3;
A7-B14-C9;
A7-B14-C15;
A7-B14-C21;
A7-B14-C27;
A7-B14-C33;
A7-B14-C39;
A7-B14-C45;
A8-B14-C5;
A8-B14-C11;
A8-B14-C17;
A8-B14-C23;
A8-B14-C29;
A8-B14-C35;
A8-B14-C41;
A9-B14-C1;
A9-B14-C7;
A9-B14-C13;
A9-B14-C19;
A9-B14-C25;
A9-B14-C31;
A9-B14-C37;
A9-B14-C43;
A10-B14-C3;
A10-B14-C9;
A10-B14C15;
A2-B14-C24;
A2-B14-C30;
A2-B14-C36;
A2-B14-C42;
A3-B14-C2;
A3-B14-C8;
A3-B14-C14;
A3-B14-C20;
A3-B14-C26;
A3-B14-C32;
A3-B14-C38;
A3-B14-C44;
A4-B14-C4;
A4-B14-C10;
A4-B14-C16;
A4-B14-C22;
A4-B14-C28;
A4-B14-C34;
A4-B14-C40;
A4-B14-C46;
A5-B14-C6;
A5-B14-C12;
A5-B14-C18;
A5-B14-C24;
A5-B14-C30;
A5-B14-C36;
A5-B14-C42;
A6-B14-C2;
A6-B14-C8;
A6-B14-C14;
A6-B14-C20;
A6-B14-C26;
A6-B14-C32;
A6-B14-C38;
A6-B14-C44;
A7-B14-C4;
A7-B14-C10;
A7-B14-C16;
A7-B14-C22;
A7-B14-C28;
A7-B14-C34;
A7-B14-C40;
A7-B14-C46;
A8-B14-C6;
A8-B14-C12;
A8-B14-C18; A8-B14-C24;
A8-B14-C30·;
A8-B14-C36;
A8-B14-C42;
A9-E14-C2;
A9-314-C8;
A9-B14-C14;
A9-B14-C20;
A9-B14-C26;
A9-B14-C32;
A9-B14-C38;
A9-B14-C44;
A10-B14-C4;
Α10-Β14C10;
A10-B14C16;
A2-B14-C25;
A2-B14-C31;
A2-B14-C37;
A2-B14-C43;
A3-B14-C3;
A3-B14-C9;
A3-B14-C15;
A3-B14-C21;
A3-B14-C27;
A3-B14-C33;
A3-B14-C39;
A3-B14-C45;
A4-B14-C5;
A4-B14-C11;
A4-B14-C17;
A4-B14-C23;
A4-B14-C29;
A4-B14-C35;
A4-B14-C41;
A5-B14-C1;
A5-B14-C7;
A5-B14-C13;
A5-B14-C19;
A5-B14-C25;
A5-B14-C31;
A5-B14-C37;
A5-B14-C43;
A6-B14-C3;
A6-B14-C9;
A6-B14-C15;
A6-B14-C21;
A6-B14-C27;
A6-B14-C33;
A6-B14-C39;
A6-B14-C45;
A7-B14-C5;
A7-B14-C11;
A7-B14-C17;
A7-B14-C23;
A7-B14-C29;
A7-B14-C35;
A7-B14-C41;
A8-B14-C1;
A8-B14-C7;
A8-B14-C13;
A8-B14-C19;
A8-B14-C25;
A8-B14-C31;
A8-B14-C37;
A8-B14-C43;
A9-B14-C3;
A9-B14-C9;
A9-B14-C15;
A9-B14-C21;
A9-B14-C27;
A9-B14-C33;
A9-B14-C39;
A9-B14-C45;
A10-B14-C5;
A10-B14Cll;
A10-B14C17;
A2-B14-C26;
A2-B14-C32;
A2-B14-C38; A2-B14-C44;
A3-B14-C4;
A3-B14-C10;
A3-B14-C16;
A3-B14-C22;
A3-B14-C28;
A3-B14-C34;
A3-B14-C40;
A3-B14-C46; A4-B14-C6;
A4-B14-C12;
A4-B14-C18;
A4-B14-C24;
A4-B14-C30;
A4-B14-C36;
A4-B14-C42;
A5-B14-C2;
A5-B14-C8;
A5-B14-C14;
A5-B14-C20;
A5-B14-C26;
A5-B14-C32;
A5-B14-C38;
A5-B14-C44; A6-B14-C4;
A6-B14-C10;
A6-B14-C16;
A6-B14-C22;
A6-B14-C28; A6-B14-C34; A6-B14-C40;
A6-B14-C46; A7-B14-C6;
A7-B14-C12;
A7-B14-C18; A7-B14-C24;
A7-B14-C30;
A7-B14-C36;
A7-B14-C42;
A8-B14-C2;
A8-B14-C8;
A8-B14-C14;
A8-B14-C20;
A8-B14-C26;
A8-B14-C32;
A8-B14-C38;
A8-B14-C44; A9-B14-C4;
A9-B14-C1O;
A9-B14-C16;
A9-B14-C22;
A9-B14-C28;
A9-B14-C34;
A9-B14-C40;
A9-B14-C46;
A10-B14-C6;
A10-B14C12;
A10-B14C18;
A2-B14-C27;
A2-B14-C33;
A2-B14-C39;
A2-B14-C45;
A3-B14-C5;
A3-B14-C11;
A3-B14-C17;
A3-B14-C23;
A3-B14-C29;
A3-B14-C35;
A3-B14-C41;
A4-B14-C1;
A4-B14-C7;
A4-B14-C13;
A4-B14-C19;
A4-B14-C25;
A4-B14-C31;
A4-B14-C37;
A4-B14-C43;
A5-B14-C3;
A5-B14-C9;
A5-B14-C15;
A5-B14-C21;
A5-B14-C27;
A5-B14-C33;
A5-B14-C39;
A5-B14-C45;
A6-B14-C5;
A6-B14-C11;
A6-B14-C17;
A6-B14-C23;
A6-B14-C29;
A6-B14-C35;
A6-B14-C41;
A7-B14-C1;
A7-B14-C7;
A7-B14-C13;
A7-B14-C19;
A7-B14-C25;
A7-B14-C31;
A7-B14-C37;
A7-B14-C43;
A8-B14-C3;
A8-B14-C9;
A8-B14-C15;
A8-B14-C21;
A8-B14-C27;
A8-B14-C33;
A8-B14-C39;
A8-B14-C45;
A9-B14-C5;
A9-B14-C11;
A9-B14-C17;
A9-B14-C23;
A9-B14-C29;
A9-B14-C35;
A9-B14-C41;
A10-B14-C1;
A10-B14-C7; A10-B14C13;
A10-B14C19;
A2-B14-C28;
A2-B14-C34;
A2-B14-C40;
A2-B14-C46;
A3-B14-C6;
A3-B14-C12;
A3-B14-C18;
A3-B14-C24;
A3-B14-C30;
A3-B14-C36;
A3-514-C42;
A4-B14-C2;
A4-B14-C8;
A4-B14-C14;
A4-B14-C20;
A4-B14-C26;
A4-B14-C32;
A4-B14-C38;
A4-B14-C44;
A5-B14-C4;
A5-B14-C10;
A5-314-C16;
A5-B14-C22;
A5-B14-C28;
A5-B14-C34;
A5-B14-C40;
A5-B14-C46;
A6-B14-C6;
A6-B14-C12;
A6-B14-C18;
A6-B14-C24;
A6-B14-C30;
A6-B14-C36;
A6-314-C42;
A7-B14-C2;
A7-B14-C8;
A7-B14-C14;
A7-B14-C20;
A7-B14-C26;
A7-314-C32;
A7-314-C38;
A7-B14-C44;
A8-314-C4;
A8-314-C10;
A8-314-C16;
A8-314-C22;
A8-314-C28;
A8-314-C34;
A8-314-C40;
A8-314-C46;
A9-B14-C6;
A9-314-C12;
A9-314-C18;
A9-314-C24;
A9-314-C30;
A9-314-C36;
A9-314-C42;
A1O-B14-C2;
A10-314-C8;
A10-314C14;
A10-B14C20;
104
<td>Α10-Β14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td><td>C2 5;</td><td>C2 6;</td>
<td>Α10-Β14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α10-Β14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>Α10-Β14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td><td>A10-B14-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α10-Β14-</td><td>A10-B14-</td><td>A11-B14-C1;</td><td>A11-B14-C2;</td><td>A11-B14-C3;</td><td>A11-B14-C4;</td>
<td>C4 5; A11-B14-C5;</td><td>C4 6; A11-B14-C6;</td><td>A11-B14-C7;</td><td>A11-B14-C8;</td><td>A11-B14-C9;</td><td>A1L-B14-</td>
<td>Α11-Β14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>C10; A11-B14-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>Α11-Β14-</td><td>A11-B14-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td>
<td>C23;</td><td>C2 4 ;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td><td>A11-B14-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A12-B14-C1;</td><td>A12-B14-C2;</td><td>A12-B14-C3;</td><td>A12-B14-C4;</td><td>A12-B14-C5;</td><td>A12-B14-C6;</td>
<td>A12-B14-C7;</td><td>A12-B14-C8;</td><td>A12-B14-C9;</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td>
<td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>C10; A12-B14-</td><td>Cll; A12-B14-</td><td>C12; A12-B14-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td>
<td>C25;</td><td>C2 6;</td><td>C2 7;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41 ;</td><td>C4 2;</td>
<td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A12-B14-</td><td>A13-B14-C1;</td><td>A13-B14-C2;</td>
<td>C4 3; A13-B14-C3;</td><td>C4 4; A13-B14-C4;</td><td>C4 5; A13-B14-C5;</td><td>C4 6; A13-B14-C6;</td><td>A13-B14-C7;</td><td>A13-B14-C8;</td>
<td>A13-B14-C9;</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A13-B14-.</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td><td>A13-B14-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A13-B14-</td><td>A13-B14-</td><td>A14-B14-C1;</td><td>A14-B14-C2;</td><td>A14-B14-C3;</td><td>A14-B14-C4;</td>
<td>C4 5; A14-B14-C5;</td><td>C4 6; A14-B14-C6;</td><td>A14-B14-C7;</td><td>A14-B14-C8;</td><td>A14-B14-C9;</td><td>A14-B14-</td>
<td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>C10; A14-B14-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td>
<td>C23;</td><td>C24;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td>
105
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>Α14-Β14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>Α14-Β14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td><td>A14-B14-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A15-B14-C1;</td><td>A15-B14-C2;</td><td>A15-B14-C3;</td><td>A15-B14-C4;</td><td>A15-B14-C5;</td><td>A15-B14-C6</td>
<td>A15-B14-C7;</td><td>A15-B14-C8;</td><td>A15-B14-C9;</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td>
<td>Α15-Β14-</td><td>A15-B14-</td><td>A15-B14-</td><td>C10; A15-B14-</td><td>Cll; A15-B14-</td><td>C12; A15-B14-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α15-Β14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-314-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>Α15-Β14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-314-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>Α15-Β14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α15-Β14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C40;</td><td>C41;</td><td>C4 2;</td>
<td>Α15-Β14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A15-B14-</td><td>A16-B14-C1;</td><td>A16-B14-C2</td>
<td>C4 3; A16-B14-C3;</td><td>C4 4; A16-B14-C4;</td><td>C4 5; A16-B14-C5;</td><td>C4 6; A16-B14-C6;</td><td>A16-B14-C7;</td><td>A16-B14-C8</td>
<td>A16-B14-C9;</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td>
<td>Α16-Β14-</td><td>C10; A16-B14-</td><td>Cll; A16-B14-</td><td>C12; A16-B14-</td><td>C13; A16-B14-</td><td>C14; A16-B14-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α16-Β14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>Α16-Β14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α16-Β14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α16-Β14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td><td>A16-B14-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α16-Β14-</td><td>A16-B14-</td><td>A17-B14-C1;</td><td>A17-B14-C2;</td><td>A17-B14-C3;</td><td>A17-B14-C4</td>
<td>C4 5; A17-B14-C5;</td><td>C46; A17-B14-C6;</td><td>A17-B14-C7;</td><td>A17-B14-C8;</td><td>A17-B14-C9;</td><td>A17-B14-</td>
<td>Α17-Β14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>C10; A17-314-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td>
<td>C2 3;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td>
<td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A17-B14-</td><td>A17-B14- </td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td><td>A17-B14-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3; '</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A18-B14-C1;</td><td>A18-B14-C2;</td><td>A18-B14-C3;</td><td>A18-B14-C4;</td><td>A18-B14-C5;</td><td>A18-B14-C6</td>
<td>A18-B14-C7;</td><td>A18-B14-C8;</td><td>A18-B14-C9;</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td>
<td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>C10; A18-B14-</td><td>Cll; A18-B14-</td><td>C12; A18-B14-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A18-B14-</td><td>A19-B14-C1;</td><td>A19-B14-C2</td>
106
<td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td colspan="3">C4 6;</td>
<td>A19-B14-C3;</td><td>A19-B14-C4;</td><td>A19-B14-C5;</td><td>A19-B14-C6;</td><td>A19-B14-C7;</td><td>A19-B14-C8;</td>
<td>A19-B14-C9;</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>Α19-Β14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α19-Β14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α19-Β14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α19-Β14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>' A19-B14-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α19-Β14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td><td>A19-B14-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α19-Β14-</td><td>A19-B14-</td><td>A20-B14-C1;</td><td>A20-B14-C2;</td><td>A20-B14-C3;</td><td>A20-B14-C4;</td>
<td>C4 5; A20-B14-C5;</td><td>C4 6; A20-B14-C6;</td><td>A20-B14-C7;</td><td>A2O-B14-C8;</td><td>A2O-B14-C9;</td><td>A20-B14-</td>
<td>Α20-Β14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>C10; A20-B14-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28 ;</td>
<td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A20-B14-</td><td>A20-314-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td><td>A20-B14-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A21-B14-C1;</td><td>A21-B14-C2;</td><td>A21-B14-C3;</td><td>A21-B14-C4;</td><td>A21-B14-C5;</td><td>A21-B14-C6;</td>
<td>A21-B14-C7;</td><td>A21-B14-C8;</td><td>A21-B14-C9;</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td>
<td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>C10; A21-B14-</td><td>Cll; A21-B14-</td><td>C12; A21-B14-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A21-B14-</td><td>A21-314-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24 ;</td>
<td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A21-B14-</td><td>A22-B14-C1;</td><td>A22-B14-C2;</td>
<td>C4 3; A22-B14-C3;</td><td>C4 4 ; A22-B14-C4;</td><td>C4 5; A22-B14-C5;</td><td>C4 6; A22-B14-C6;</td><td>A22-B14-C7;</td><td>A22-B14-C8;</td>
<td>A22-B14-C9;</td><td>A22-314-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td>
<td></td><td>C10;</td><td>Cll; .</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;·</td><td>C20;</td>
<td>A22-B14-</td><td>A22-314-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C2 5;</td><td>C2 6;</td>
<td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-314-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A22-B14-</td><td>A22-314-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A22-B14-</td><td>A22-314-</td><td>Ά22-Β14-</td><td>A22-B14-</td><td>A22-B14-</td><td>A22-B14-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>A22-B14-</td><td>A22-B14-</td><td>A23-B14-C1;</td><td>A23-B14-C2;</td><td>A23-B14-C3;</td><td>A23-B14-C4;</td>
<td>C4 5; A23-B14-C5;</td><td>C4 6; A23-B14-C6;</td><td>A23-B14-C7;</td><td>A23-B14-C8;</td><td>A23-B14-C9;</td><td>A23-B14-</td>
<td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>C10; A23-B14-</td>
107
<td>Cl 1 ;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td>
<td>C2 3;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td><td>A23-B14-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td> 04 6;</td>
<td>A24-B14-C1;</td><td>A24-B14-C2;</td><td>A24-B14-C3;</td><td>A24-314-C4;</td><td>A24-B14-C5;</td><td>A24-B14-C6</td>
<td>A24-B14-C7;</td><td>A24-B14-C8;</td><td>A24-B14-C9;</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td>
<td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>C10; A24-B14-</td><td>Cll; A24-B14-</td><td>C12; A24-B14-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A24-B14-</td><td>A24-B14-</td><td>A24-314-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-314-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-314-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-314-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A24-B14-</td><td>A25-B14-C1;</td><td>A25-314-C2</td>
<td>C4 3; A25-B14-C3;</td><td>C4 4; A25-B14-C4;</td><td>C4 5; A25-B14-C5;</td><td>C4 6; A25-B14-C6;</td><td>A25-B14-C7;</td><td>A25-314-C8</td>
<td>A25-B14-C9;</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>Α2Ξ-Β14-</td>
<td>A25-B14-</td><td>C10; A25-B14-</td><td>Cll; A25-B14-</td><td>C12; A25-314-</td><td>C13; A25-B14-</td><td>C14 ; Α25-Ξ14-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C2C;</td>
<td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-314-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td><td>A25-B14-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A25-B14-</td><td>A25-B14-</td><td>A26-B14-C1;</td><td>A26-B14-C2;</td><td>A26-B14-C3;</td><td>A26-314-C4</td>
<td>C4 5; A26-B14-C5;</td><td>C4 6; A26-B14-C6;</td><td>A26-B14-C7;</td><td>A26-B14-C8;</td><td>A26-B14-C9;</td><td>A26-B14-</td>
<td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>C1C; Α26-Ξ14-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A26-B14-</td><td>A26-B14-</td><td>A26-314-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-314-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A26-B14-</td><td>A26-B14- </td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-314-</td>
<td>C33;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-B14-</td><td>A26-314-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A27-B14-C1;</td><td>A27-B14-C2;</td><td>A27-314-C3;</td><td>A27-B14-C4;</td><td>A27-B14-C5;</td><td>A27-314-C6</td>
<td>A27-B14-C7;</td><td>A27-B14-C8;</td><td>A27-B14-C9;</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-314-</td>
<td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>C10; A27-B14-</td><td>Cll; A27-B14-</td><td>C12; Α27-Ξ14-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-314-</td>
108
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α27-Β14-</td><td>Α27-Β14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td>
<td>C31 ;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α27-Β14-</td><td>Α27-Β14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A27-B14-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>Α27-Β14-</td><td>Α27-Β14-</td><td>A27-B14-</td><td>A27-B14-</td><td>A28-B14-C1;</td><td>A28-314-C2;</td>
<td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
<td>A28-B14-C3;</td><td>A28-B14-C4;</td><td>A28-B14-C5;</td><td>A28-B14-C6;</td><td>A28-B14-C7;</td><td>A28-314-C8;</td>
<td>A28-B14-C9;</td><td>Α28-Β14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-314-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>Α28-Β14-</td><td>A28-B14-</td><td>A28-B14- '</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-314-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α28-Β14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-314-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 8;</td>
<td>Α28-Β14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A2S-314-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α28-Β14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-314-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>Α28-Β14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-B14-</td><td>A28-314-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α28-Β14-</td><td>A28-B14-</td><td>A1-B15-C1;</td><td>A1-B15-C2;</td><td>A1-B15-C3;</td><td>A1-315-C4;</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td>
<td>A1-B15-C5;</td><td>A1-B15-C6;</td><td>A1-B15-C7;</td><td>A1-B15-C8;</td><td>A1-B15-C9;</td><td>A1-315-C10;</td>
<td>A1-B15-C11;</td><td>A1-B15-C12;</td><td>A1-315-C13;</td><td>A1-B15-C14;</td><td>A1-B15-C15;</td><td>A1-315-C16;</td>
<td>A1-B15-C17;</td><td>A1-B15-C18;</td><td>A1-B15-C19;</td><td>A1-B15-C20;</td><td>A1-B15-C21;</td><td>A1-315-C22;</td>
<td>A1-B15-C23;</td><td>A1-B15-C24 ;</td><td>A1-315-C25;</td><td>A1-B15-C26;</td><td>A1-B15-C27;</td><td>A1-315-C28;</td>
<td>A1-B15-C29;</td><td>A1-B15-C30;</td><td>A1-315-C31;</td><td>A1-B15-C32;</td><td>A1-B15-C33;</td><td>A1-315-C34;</td>
<td>A1-B15-C35;</td><td>A1-B15-C36;</td><td>A1-B15-C37;</td><td>A1-B15-C38;</td><td>A1-B15-C39;</td><td>A1-315-C40;</td>
<td>A1-B15-C41;</td><td>A1-B15-C42;</td><td>A1-B15-C43;</td><td>A1-B15-C44;</td><td>A1-B15-C45;</td><td>A1-315-C46;</td>
<td>A2-B15-C1;</td><td>A2-B15-C2;</td><td>A2-315-C3;</td><td>A2-B15-C4;</td><td>A2-B15-C5;</td><td>A2-315-C6;</td>
<td>A2-B15-C7;</td><td>A2-B15-C8;</td><td>A2-B15-C9;</td><td>A2-B15-C10;</td><td>A2-B15-C11;</td><td>A2-B15-C12;</td>
<td>A2-B15-C13;</td><td>A2-B15-C14;</td><td>A2-B15-C15;</td><td>A2-B15-C16;</td><td>A2-B15-C17;</td><td>A2-315-C18;</td>
<td>A2-B15-C19;</td><td>A2-B15-C20;</td><td>A2-315-C21;</td><td>A2-B15-C22;</td><td>A2-B15-C23;</td><td>A2-315-C24;</td>
<td>A2-B15-C25;</td><td>A2-B15-C26;</td><td>A2-B15-C27;</td><td>A2-B15-C28;</td><td>A2-B15-C29;</td><td>A2-315-C30;</td>
<td>A2-B15-C31;</td><td>A2-B15-C32;</td><td>A2-315-C33;</td><td>A2-B15-C34;</td><td>A2-B15-C35;</td><td>A2-315-C36;</td>
<td>A2-B15-C37;</td><td>A2-B15-C38;</td><td>A2-B15-C39;</td><td>A2-B15-C40;</td><td>A2-B15-C41;</td><td>A2-315-C42;</td>
<td>A2-B15-C43;</td><td>A2-B15-C44;</td><td>A2-315-C45;</td><td>A2-B15-C46;</td><td>A3-B15-C1;</td><td>A3-315-C2;</td>
<td>A3-B15-C3;</td><td>A3-B15-C4;</td><td>A3-315-C5;</td><td>A3-B15-C6;</td><td>A3-B15-C7;</td><td>A3-315-C8;</td>
<td>A3-B15-C9;,</td><td>A3-B15-C10;</td><td>A3-B15-C11;</td><td>A3-B15-C12;</td><td>A3-B15-C13;</td><td>A3-315-C14;</td>
<td>A3-B15-C15;</td><td>A3-B15-C16;</td><td>A3-315-C17;</td><td>A3-B15-C18;</td><td>A3-B15-C19;</td><td>A3-B15-C20;</td>
<td>A3-B15-C21;</td><td>A3-B15-C22;</td><td>A3-B15-C23;</td><td>A3-B15-C24;</td><td>A3-B15-C25;</td><td>A3-315-C26;</td>
<td>A3-B15-C27;</td><td>A3-B15-C28;</td><td>A3-315-C29;</td><td>A3-B15-C30;</td><td>A3-B15-C31;</td><td>A3-315-C32;</td>
<td>A3-B15-C33;</td><td>A3-B15-C34;</td><td>A3-B15-C35;</td><td>A3-B15-C36;</td><td>A3-B15-C37;</td><td>A3-315-C38;</td>
<td>A3-B15-C39;</td><td>A3-B15-C40;</td><td>A3-315-C41;</td><td>A3-B15-C42;</td><td>A3-B15-C43;</td><td>A3-315-C44;</td>
<td>A3-B15-C45;</td><td>A3-B15-C46;</td><td>A4-B15-C1;</td><td>A4-B15-C2;</td><td>A4-B15-C3;</td><td>A4-315-C4;</td>
<td>A4-B15-C5;</td><td>A4-B15-C6;</td><td>A4-B15-C7;</td><td>A4-B15-C8;</td><td>A4-B15-C9;</td><td>A4-B15-C10;</td>
<td>A4-B15-C11;</td><td>A4-B15-C12;</td><td>A4-B15-C13;</td><td>A4-B15-C14;</td><td>A4-B15-C15;</td><td>A4-315-C16;</td>
<td>A4-B15-C17;</td><td>A4-B15-C18;</td><td>A4-315-C19;</td><td>A4-B15-C20;</td><td>A4-B15-C21;</td><td>A4-315-C22;</td>
<td>A4-B15-C23;</td><td>A4-B15-C24;</td><td>A4-315-C25;</td><td>A4-B15-C26;</td><td>A4-B15-C27;</td><td>A4-315-C28;</td>
<td>A4-B15-C29;</td><td>A4-B15-C30;</td><td>A4-B15-C31;</td><td>A4-B15-C32;</td><td>A4-B15-C33;</td><td>A4-315-C34;</td>
<td>A4-B15-C35;</td><td>A4-B15-C36;</td><td>A4-B15-C37;</td><td>A4-B15-C38;</td><td>A4-B15-C39;</td><td>A4-315-C40;</td>
<td>A4-B15-C41;</td><td>A4-B15-C42;</td><td>A4-315-C43;</td><td>A4-B15-C44;</td><td>A4-B15-C45;</td><td>A4-315-C46;</td>
<td>A5-B15-C1;</td><td>A5-B15-C2;</td><td>A5-B15-C3;</td><td>A5-B15-C4;</td><td>A5-B15-C5;</td><td>A5-315-C6;</td>
<td>A5-B15-C7;</td><td>A5-B15-C8;</td><td>A5-315-C9;</td><td>A5-B15-C10;</td><td>A5-B15-C11;</td><td>A5-315-C12;</td>
<td>A5-B15-C13;</td><td>A5-B15-C14;</td><td>A5-B15-C15;</td><td>A5-B15-C16;</td><td>A5-B15-C17;</td><td>A5-315-C18;</td>
<td>A5-315-C19;</td><td>A5-B15-C20;</td><td>A5-B15-C21;</td><td>A5-B15-C22;</td><td>A5-B15-C23;</td><td>A5-315-C24;</td>
<td>A5-B15-C25;</td><td>A5-B15-C26;</td><td>A5-B15-C27;</td><td>A5-B15-C28;</td><td>A5-B15-C29;</td><td>A5-315-C30;</td>
<td>A5-B15-C31;</td><td>A5-B15-C32;</td><td>A5-B15-C33;</td><td>A5-B15-C34;</td><td>A5-B15-C35;</td><td>A5-315-C36;</td>
<td>A5-B15-C37;</td><td>A5-B15-C38;</td><td>A5-B15-C39;</td><td>A5-B15-C40;</td><td>A5-B15-C41;</td><td>A5-315-C42;</td>
<td>A5-B15-C43;</td><td>A5-B15-C44;</td><td>A5-B15-C45;</td><td>A5-B15-C46;</td><td>A6-B15-C1;</td><td>A6-315-C2;</td>
<td>A6-B15-C3;</td><td>A6-B15-C4;</td><td>A6-315-C5;</td><td>A6-B15-C6;</td><td>A6-B15-C7;</td><td>A6-315-C8;</td>
<td>A6-315-C9;</td><td>A6-B15-C10;</td><td>A6-B15-C11;</td><td>A6-B15-C12;</td><td>A6-B15-C13;</td><td>A6-315-C14;</td>
<td>A6-B15-C15;</td><td>A6-B15-C16;</td><td>A6-B15-C17;</td><td>A6-B15-C18;</td><td>A6-B15-C19;</td><td>A6-315-C20;</td>
109
<td>A6-B15-C21;</td><td>A6-B15-C22;</td><td>A6-B15-C23;</td><td>A6-B15-C24;</td><td>A6-B15-C25;</td><td>A6-B15-C26;</td>
<td>A6-B15-C27;</td><td>A6-B15-C28;</td><td>A6-B15-C29;</td><td>A6-B15-C3O;</td><td>A6-B15-C31;</td><td>A6-B15-C32;</td>
<td>A6-B15-C33;</td><td>A6-B15-C34;</td><td>A6-B15-C35;</td><td>A6-B15-C36;</td><td>A6-B15-C37;</td><td>A6-B15-C38;</td>
<td>A6-B15-C39;</td><td>A6-B15-C40;</td><td>A6-B15-C41;</td><td>A6-B15-C42;</td><td>A6-B15-C43;</td><td>A6-B15-C44;</td>
<td>A6-B15-C45;</td><td>A6-B15-C46;</td><td>A7-B15-C1;</td><td>A7-B15-C2;</td><td>A7-B15-C3;</td><td>A7-B15-C4;</td>
<td>A7-B15-C5;</td><td>A7-B15-C6;</td><td>A7-B15-C7;</td><td>A7-B15-C8;</td><td>A7-B15-C9;</td><td>A7-B15-C10;</td>
<td>A7-B15-C11;</td><td>A7-B15-C12;</td><td>A7-B15-C13;</td><td>A7-B15-C14;</td><td>A7-B15-C15;</td><td>A7-B15-C16;</td>
<td>A7-B15-C17;</td><td>A7-B15-C18;</td><td>A7-B15-C19;</td><td>A7-B15-C20;</td><td>A7-B15-C21;</td><td>A7-B15-C22;</td>
<td>A7-B15-C23;</td><td>A7-B15-C24;</td><td>A7-B15-C25;</td><td>A7-B15-C26;</td><td>A7-B15-C27;</td><td>A7-B15-C28;</td>
<td>A7-B15-C29;</td><td>A7-B15-C30;</td><td>A7-B15-C31;</td><td>A7-B15-C32;</td><td>A7-B15-C33;</td><td>A7-B15-C34;</td>
<td>A7-B15-C35;</td><td>A7-B15-C36;</td><td>A7-B15-C37;</td><td>A7-B15-C38;</td><td>A7-B15-C39;</td><td>A7-B15-C40;</td>
<td>A7-B15-C41;</td><td>A7-B15-C42;</td><td>A7-B15-C43;</td><td>A7-B15-C44;</td><td>A7-B15-C45;</td><td>A7-B15-C46;</td>
<td>A8-B15-C1;</td><td>A8-B15-C2;</td><td>A8-B15-C3;</td><td>A8-B15-C4;</td><td>A8-B15-C5;</td><td>A8-315-C6;</td>
<td>A8-B15-C7;</td><td>A8-B15-C8;</td><td>A8-B15-C9;</td><td>A8-B15-C1O;</td><td>A8-B15-C11;</td><td>A8-B15-C12;</td>
<td>A8-B15-C13;</td><td>A8-B15-C14;</td><td>A8-B15-C15;</td><td>A8-B15-C16;</td><td>A8-B15-C17;</td><td>A8-B15-C18;</td>
<td>A8-B15-C19;</td><td>A8-B15-C20;</td><td>A8-B15-C21;</td><td>A8-B15-C22;</td><td>A8-B15-C23;</td><td>A8-B15-C24;</td>
<td>A8-B15-C25;</td><td>A8-B15-C26;</td><td>A8-B15-C27;</td><td>A8-B15-C28;</td><td>A8-B15-C29;</td><td>A8-B15-C30;</td>
<td>A8-B15-C31;</td><td>A8-B15-C32;</td><td>A8-B15-C33;</td><td>A8-B15-C34;</td><td>A8-B15-C35;</td><td>A8-B15-C36;</td>
<td>A8-B15-C37;</td><td>A8-B15-C38;</td><td>A8-B15-C39;</td><td>A8-B15-C40;</td><td>A8-B15-C41;</td><td>A8-B15-C42;</td>
<td>A8-B15-C43;</td><td>A8-B15-C44;</td><td>A8-B15-C45;</td><td>A8-B15-C46;</td><td>A9-B15-C1;</td><td>A9-B15-C2;</td>
<td>A9-B15-C3;</td><td>A9-B15-C4;</td><td>A9-B15-C5;</td><td>A9-B15-C6;</td><td>A9-B15-C7;</td><td>A9-B15-C8;</td>
<td>A9-B15-C9;</td><td>A9-B15-C10;</td><td>A9-B15-C11;</td><td>A9-B15-C12;</td><td>A9-B15-C13;</td><td>A9-B15-C14;</td>
<td>A9-B15-C15;</td><td>A9-B15-C16;</td><td>A9-B15-C17;</td><td>A9-B15-C18;</td><td>A9-B15-C19;</td><td>A9-315-C20;</td>
<td>A9-B15-C21;</td><td>A9-B15-C22;</td><td>A9-B15-C23;</td><td>A9-B15-C24;</td><td>A9-B15-C25;</td><td>A9-B15-C26;</td>
<td>A9-B15-C27;</td><td>A9-B15-C28;</td><td>A9-B15-C29;</td><td>A9-B15-C30;</td><td>A9-B15-C31;</td><td>A9-B15-C32;</td>
<td>A9-B15-C33;</td><td>A9-B15-C34;</td><td>A9-B15-C35;</td><td>A9-B15-C36;</td><td>A9-B15-C37;</td><td>A9-B15-C38;</td>
<td>A9-B15-C39;</td><td>A9-B15-C40;</td><td>A9-B15-C41;</td><td>A9-B15-C42;</td><td>A9-B15-C43;</td><td>A9-B15-C44;</td>
<td>A9-B15-C45;</td><td>A9-B15-C46;</td><td>A10-B15-C1;</td><td>A10-B15-C2;</td><td>A10-B15-C3';</td><td>A10-B15-C4;</td>
<td>A10-B15-C5;</td><td>A10-B15-C6;</td><td>A10-B15-C7;</td><td>A10-B15-C8;</td><td>A10-B15-C9;</td><td>A10-B15-</td>
<td>Α10-Β15-</td><td>A10-B15-</td><td>A10-315-</td><td>A10-B15-</td><td>A10-B15-</td><td>C10; AL0-B15-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A13-B15- </td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C23;</td>
<td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C3 4;</td>
<td>A10-B15-</td><td>A10-B15-</td><td>A10-315- </td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td><td>A10-B15-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A11-B15-C1;</td><td>A11-B15-C2;</td><td>Al1-BI 5-C3;</td><td>A11-B15-C4;</td><td>A11-B15-C5;</td><td>A11-B15-C6;</td>
<td>A1Í-B15-C7;</td><td>A11-B15-C8;</td><td>A11-B15-C9;</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td>
<td>A11-B15-</td><td>A11-B15-</td><td>All-315-</td><td>C10; A11-B15-</td><td>Cll; A11-B15-</td><td>C12; A11-B15-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C13;</td>
<td>A11-B15-</td><td>A11-B15- ·</td><td>All-315-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td>
<td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A11-B15-</td><td>A12-B15-C1;</td><td>A12-B15-C2;</td>
<td>C4 3; A12-B15-C3;</td><td>C4 4; A12-B15-C4;</td><td>C4 5; A12-315-C5;</td><td>C4 6; A12-B15-C6;</td><td>A12-B15-C7;</td><td>A12-BI5-C8;</td>
<td>A12-B15-C9;</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td>
<td>A12-B15-</td><td>C10; A12-B15-</td><td>Cll; A12-B15-</td><td>C12; A12-B15-</td><td>C13; A12-B15-</td><td>C14; A12-B15-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td>
110
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>Α12-Β15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α12-Β15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α12-Β15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td><td>A12-B15-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C42;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α12-Β15-</td><td>A12-B15-</td><td>A13-B15-C1;</td><td>A13-B15-C2;</td><td>A13-B15-C3;</td><td>A13-B15-C4</td>
<td>C4 5; A13-B15-C5;</td><td>C4 6; A13-B15-C6;</td><td>A13-B15-C7;</td><td>A13-B15-C8;</td><td>A13-B15-C9;</td><td>A13-B15-</td>
<td>Α13-Β15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>C10; A13-B15-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C2 8;</td>
<td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td><td>A13-B15-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ,-</td><td>C4 5;</td><td>C4 6;</td>
<td>A14-B15-C1;</td><td>A14-B15-C2;</td><td>A14-B15-C3;</td><td>ΑΙ 4 -B15-C4 ;</td><td>A14-B15-C5;</td><td>A14-B15-C6</td>
<td>A14-B15-C7;</td><td>A14-B15-C8;</td><td>A14-B15-C9;</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td>
<td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>C10; A14-B15-</td><td>Cll; A14-B15-</td><td>C12; A14-B15-</td>
<td>C13;</td><td>C14</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24;</td>
<td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A14-B15-</td><td>A15-B15-C1;</td><td>A15-B15-C2</td>
<td>C4 3; A15-B15-C3;</td><td>C4 4; A15-B15-C4;</td><td>C4 5; A15-B15-C5;</td><td>C4 6; A15-B15-Co;</td><td>A15-B15-C7;</td><td>A15-B15-C8</td>
<td>A15-B15-C9;</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td><td>C2 5;</td><td>C2 6;</td>
<td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A15-B15-</td><td>A15-B15- '</td><td>'A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A15-B15-</td><td>A15-315-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td><td>A15-B15-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A15-B15-</td><td>A15-B15-</td><td>A16-B15-C1;</td><td>A16-B15-C2;</td><td>A16-B15-C3;</td><td>A16-B15-C4</td>
<td>C4 3; A16-B15-C5;</td><td>C4 6; A16-B15-C6;</td><td>A16-B15-C7;</td><td>A16-B15-C8;</td><td>A16-B15-C9;</td><td>A16-B15-</td>
<td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>C10; A16-B15-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td>
<td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C2 8;</td>
<td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
111
<td>Α16-Β15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>Α16-Β15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td><td>A16-B15-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A17-B15-C1;</td><td>A17-B15-C2;</td><td>A17-B15-C3;</td><td>A17-B15-C4;</td><td>A17-B15-C5;</td><td>A17-B15-C6;</td>
<td>A17-B15-C7;</td><td>A17-B15-C8;</td><td>A17-B15-C9;</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td>
<td></td><td></td><td></td><td>C1O;</td><td>Cll;</td><td>C12;</td>
<td>Α17-Β15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α17-Β15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24 ;</td>
<td>Α17-Β15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α17-Β15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α17-Β15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td>
<td>C37;</td><td>' C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α17-Β15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A17-B15-</td><td>A18-B15-C1;</td><td>A18-B15-C2;</td>
<td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
<td>A18-B15-C3;</td><td>A18-B15-C4;</td><td>A18-B15-C5;</td><td>A18-B15-C6;</td><td>A18-B15-C7;</td><td>A18-B15-C8;</td>
<td>A18-B15-C9;</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>Α18-Β15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td>
<td>C15 ;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α18-Β15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α18-Β15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α18-Β15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α18-Β15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td><td>A18-B15-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α18-Β15-</td><td>A18-B15-</td><td>A19-B15-C1;</td><td>A19-B15-C2;</td><td>A19-B15-C3;</td><td>A19-B15-C4;</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td>
<td>A19-B15-C5;</td><td>A19-B15-C6;</td><td>A19-B15-C7;</td><td>A19-B15-C8;</td><td>A19-B15-C9;</td><td>A19-B15- C1O;</td>
<td>Α19-Β15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td>
<td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>Ά19-Β15-</td><td>A19-B15-</td><td>A19-B15-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A19-B15-</td><td>A19-B15- .·</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td><td>A19-B15-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A20-B15-C1;</td><td>A20-B15-C2;</td><td>A20-B15-C3;</td><td>A20-B15-C4;</td><td>A20-B15-C5;</td><td>A20-B15-C6;</td>
<td>A20-B15-C7;</td><td>A20-B15-C8;</td><td>A20-B15-C9;</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td>
<td></td><td></td><td></td><td>C1O;</td><td>Cll;</td><td>C12;</td>
<td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td>
<td>C25 ;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-BI5-</td>
<td>C37 ;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A20-B15-</td><td>A21-B15-C1;</td><td>A21-B15-C2;</td>
<td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
112
<td>A21-B15-C3;</td><td>A21-B15-C4;</td><td>A21-B15-C5;</td><td>A21-B15-C6;</td><td>A21-B15-C7;</td><td>A21-B15-C8;</td>
<td>A21-B15-C9;</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>Α21-Β15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α21-Β15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td>
<td>Α21-Β15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α21-Β15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>Α21-Β15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td><td>A21-B15-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C42;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α21-Β15-</td><td>A21-B15-</td><td>A22-B15-C1;</td><td>A22-B15-C2;</td><td>A22-B15-C3;</td><td>A22-B15-C4;</td>
<td>C4 5; A22-B15-C5;</td><td>C4 6; A22-B15-C6;</td><td>A22-B15-C7;</td><td>A22-B15-C8;</td><td>A22-B15-C9;</td><td>A22-B15-</td>
<td>Α22-Β15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>C1O; A22-B15-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-’</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td>
<td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td><td>A22-B15-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A23-B15-C1;</td><td>A23-B15-C2;</td><td>A23-B15-C3;</td><td>A23-B15-C4;</td><td>A23-B15-C5;</td><td>A23-B15-C6;</td>
<td>A23-B15-C7;</td><td>A23-B15-C8;</td><td>A23-B15-C9;</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td>
<td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>C1O; A23-B15-</td><td>Cll; A23-B15-</td><td>C12; A23-B15-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A23-B15-</td><td>A24-B15-C1;</td><td>A24-B15-C2;</td>
<td>C4 3; A24-B15-C3;</td><td>C4 4; A24-B15-C4;</td><td>C4 5; A24-B15-C5;</td><td>C46; A24-B15-C6;</td><td>A2.4-B15-C7;</td><td>A24-B15-C8;</td>
<td>A24-B15-C9;</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td>
<td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td><td>A24-B15-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A24-B15-</td><td>A24-B15-</td><td>A25-B15-C1;</td><td>A25-B15-C2;</td><td>A25-B15-C3;</td><td>A25-B15-C4;</td>
<td>C4 5; A25-B15-C5;</td><td>C4 6; A25-B15-C6;</td><td>A25-B15-C7;</td><td>A25-B15-C8;</td><td>A25-B15-C9;</td><td>A25-B15-</td>
<td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>C1O; A25-B15-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
113
<td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td>
<td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td>
<td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td>
<td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td>
<td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td><td>A25-B15-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td>
<td>A26-B15-C1;</td><td>A26-B15-C2;</td><td>A26-B15-C3;</td><td>A26-B15-C4;</td><td>A26-B15-C5;</td>
<td>A26-B15-C7;</td><td>A26-315-C8;</td><td>A26-B15-C9;</td><td>A26-B15-</td><td>A26-B15-</td>
<td></td><td></td><td></td><td>C1O;</td><td>Cll;</td>
<td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td>
<td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td>
<td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td>
<td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td>
<td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td>
<td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A26-B15-</td><td>A27-B15-C1;</td>
<td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td>
<td>A27-B15-C3;</td><td>A27-B15-C4;</td><td>A27-B15-C5;</td><td>A27-B15-C6;</td><td>A27-B15-C7;</td>
<td>A27-B15-C9;</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td>
<td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td>
<td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td>
<td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td>
<td>A27-B15-</td><td>A27-B15-</td><td>A27-B15-</td><td>A27-B15- ’</td><td>A27-B15-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td>
<td>A27-B15-</td><td>A27-B15-</td><td>A27-B15- </td><td>A27-B15-</td><td>A27-B15-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td>
<td>A27-B15-</td><td>A27-B15-</td><td>A28-B15-C1;</td><td>A28-B15-C2;</td><td>A28-B15-C3;</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td>
<td>A28-B15-C5;</td><td>A28-B15-C6;</td><td>A28-B15-C7;</td><td>A28-B15-C8;</td><td>A28-B15-C9;</td>
<td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td>
<td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td>
<td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td>
<td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td>
<td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td>
<td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td><td>A28-B15-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td>
<td>A1-B16-C1;</td><td>A1-B16-C2;</td><td>A1-B16-C3;</td><td>A1-B16-C4;</td><td>A1-B16-C5;</td>
<td>A1-B16-C7;</td><td>A1-B16-C8;</td><td>A1-B16-C9;</td><td>A1-B16-C10;</td><td>A1-B16-C11;</td>
<td>A1-B16-C13;</td><td>A1-B16-C14 ;</td><td>A1-B16-C15;</td><td>A1-B16-C16;</td><td>A1-B16-C17;</td>
<td>A1-B16-C19;</td><td>A1-B16-C20;</td><td>A1-B16-C21;</td><td>A1-B16-C22;</td><td>A1-B16-C23;</td>
<td>A1-B16-C25;</td><td>A1-B16-C26;</td><td>A1-B16-C27;</td><td>A1-B16-C28;</td><td>A1-B16-C29;</td>
<td>A1-B16-C31;</td><td>A1-B16-C32;</td><td>A1-B16-C33;</td><td>A1-B16-C34;</td><td>A1-B16-C35;</td>
<td>A1-316-C37;</td><td>A1-B16-C38 ;</td><td>A1-B16-C39;</td><td>A1-B16-C40;</td><td>A1-B16-C41;</td>
<td>A1-B16-C43;</td><td>A1-B16-C44;</td><td>A1-B16-C45;</td><td>A1-B16-C46;</td><td>A2-B16-C1;</td>
<td>A2-B16-C3;</td><td>A2-B16-C4;</td><td>A2-B16-C5;</td><td>A2-B16-C6;</td><td>A2-B16-C7;</td>
Α25-Β15C22;
Α25-Β15C28;
Α25-Β15C34;
Α25-Β15C4 0;
Α25-315C4 6;
A26-B15-C6;
Α26-Β15C12;
Α2 6 - 315 C18;
A26-315C24 ;
A26-315C30;
A26-B15C36;
A26-B15C4 2;
A27-B15-C2;
A27-B15-C8;
A27-B15C14;
A27-315C20;
A27-BL5C2 6;
Α27-Ξ15C32;
A27-315C38;
A27-315C4 4;
A28-B15-C4;
A28-B15C10;
A28-315C16;
A28-B15C22;
A28-B15C28;
A28-315C34;
A28-B15C4O;
A28-315C4 6;
A1-B16-C6;
A1-B16-C12;
A1-316-C18;
A1-B16-C24;
A1-B16-C30;
A1-B16-C36;
A1-B16-C42;
A2-B16-C2;
A2-B16-C8;
114
A2-B16-C9;
A2-B16-C15;
A2-B16-C21;
A2-B16-C27;
A2-B16-C33;
A2-B16-C39;
A2-B16-C45; A3-B16-C5;
A3-B16-C11;
A3-B16-C17;
A3-B16-C23;
A3-B16-C29;
A3-B16-C35;
A3-B16-C41;
A4-B16-C1;
A4-B16-C7;
A4-B16-C13;
A4-B16-C19;
A4-B16-C25;
A4-B16-C31;
A4-B16-C37;
A4-B16-C43;
A5-B1S-C3;
A5-B16-C9;
A5-B16-C15;
A5-B16-C21;
A5-B16-C27;
A5-B16-C33;
A5-B16-C39;
A5-B16-C45;
A6-B16-C5;
A6-B16-C11;
A6-B16-C17;
A6-B16-C23;
A6-B16-C29;
A6-B16-C35;
A6-B16-C41;
A7-B16-C1;
A7-B16-C7;
A7-B16-C13;
A7-B16-C19;
A7-B16-C25;
A7-B16-C31;
A7-B16-C37;
A7-B16-C43;
A8-B16-C3;
A8-B16-C9;
A8-B16-C15;
A8-B16-C21;
A8-B16-C27;
A8-B16-C33;
A8-B16-C39;
A8-B16-C45; A9-B16-C5;
A9-B16-C11;
A9-B16-C17;
A9-B16-C23;
A9-B16-C29;
A9-B16-C35;
A9-B16-C41;
A10-B16-C1;
A10-B16-C7;
A2-B16-C10;
A2-B16-C16;
A2-B16-C22;
A2-B16-C28;
A2-B16-C34;
A2-B16-C40;
A2-B16-C4 6;
A3-B16-C6;
A3-B16-C12;
A3-B16-C18;
A3-B16-C24;
A3-B16-C30;
A3-B16-C36;
A3-B16-C42;
A4-B16-C2;
A4-B16-C8;
A4-B16-C14;
A4-B16-C20;
A4-B16-C26;
A4-B16-C32;
A4-B16-C38;
A4-B16-C44;
A5-B16-C4;
A5-B16-C10;
A5-B16-C16;
A5-B16-C22;
A5-B16-C28;
A5-B16-C34 ;
A5-B16-C4O;
A5-B16-C46;
A6-B16-C6;
A6-B16-C12;
A6-B16-C18;
A6-B16-C24;
A6-B16-C30;
A6-B16-C36;
A6-B16-C42;
A7-B16-C2;
A7-B16-C8;
A7-B16-C14;
A7-B16-C20;
A7-B16-C26;
A7-B16-C32;
A7-B16-C38;
A7-B16-C44;
A8-B16-C4;
A8-B16-C10;
A8-B16-C16.;
A8-B16-C22;
A8-B16-C28;
A8-B16-C34;
A8-B16-C40;
A8-B16-C46;
A9-B16-C6;
A9-B16-C12;
A9-B16-C18;
A9-B16-C24;
A9-B16-C30;
A9-B16-C36;
A9-B16-C42;
A10-B16-C2;
A10-B16-C8;
A2-B16-C11;
A2-B16-C17;
A2-B16-C23;
A2-B16-C29;
A2-B16-C35;
A2-B16-C41;
A3-B16-C1;
A3-B16-C7;
A3-B16-C13;
A3-B16-C19;
A3-B16-C25;
A3-B16-C31;
A3-B16-C37;
A3-B16-C43;
A4-B16-C3;
A4-B16-C9;
A4-B16-C15;
A4-B16-C21;
A4-B16-C27;
A4-B16-C33;
A4-B16-C39;
A4-B16-C45;
A5-B16-C5;
A5-B16-C11;
A5-B16-C17;
A5-B16-C23;
A5-B16-C29;
A5-B16-C35;
A5-B16-C41;
A6-B16-C1;
A6-B16-C7;
A6-B16-C13;
A6-B16-C19;
A6-B16-C25;
A6-B16-C31;
A6-B16-C37;
A6-B16-C43;
A7-B16-C3;
A7-B16-C9;
A7-B16-C15;
A7-B16-C21;
A7-B16-C27;
A7-B16-C33;
A7-B16-C39;
A7-B16-C45;
A8-B16-C5;
A8-B16-C11;
A8-B16-C17;
A8-B16-C23;
A8-B16-C29;
A8-B16-C35;
A8-B16-C41;
A9-B16-C1;
A9-B16-C7;
A9-B16-C13;
A9-B16-C19;
A9-B16-C25;
A9-B16-C31;
A9-B16-C37;
A9-B16-C43;
A10-B16-C3;
A10-B16-C9;
A2-B16-C12;
A2-B16-C18;
A2-B16-C24;
A2-B16-C30;
A2-B16-C36;
A2-B16-C42;
A3-B16-C2;
A3-B16-C8;
A3-B16-C14;
A3-B16-C20;
A3-B16-C26;
A3-B16-C32;
A3-B16-C38;
A3-B16-C44;
A4-B16-C4;
A4-B16-C10;
A4-B16-C16;
A4-B16-C22;
A4-B16-C28;
A4-B16-C34;
A4-B16-C40;
A4-B16-C46;
A5-B16-C6;
A5-B16-C12;
A5-B16-C18;
A5-B16-C24;
A5-B16-C30;
A5-B16-C36;
A5-B16-C42;
A6-B16-C2;
A6-B16-C8;
A6-B16-C14;
A6-B16-C20;
A6-B16-C26;
A6-B16-C32;
A6-B16-C38;
A6-B16-C44;
A7-B16-C4;
A7-B16-C10;
A7-B16-C16;
A7-B16-C22;
A7-B16-C28;
A7-B16-C34;
A7-B16-C40;
A7-B16-C46; A8-B16-C6;
A8-B16-C12;
A8-B16-C18;
A8-B16-C24;
A8-B16-C30;
A8-B16-C36;
A8-B16-C42;
A9-B16-C2;
A9-B16-C8;
A9-B16-C14;
A9-B16-C20;
A9-B16-C26;
A9-B16-C32;
A9-B16-C38;
A9-B16-C44;
A10-B16-C4;
Α10-Β16C10;
A2-B16-C13;
A2-B16-C19;
A2-B16-C25;
A2-B16-C31;
A2-B16-C37;
A2-B16-C43;
A3-B16-C3;
A3-B16-C9;
A3-B16-C15;
A3-B16-C21;
A3-B16-C27;
A3-B16-C33;
A3-B16-C39;
A3-B16-C45; A4-B16-C5;
A4-B16-C11;
A4-B16-C17;
A4-B16-C23;
A4-B16-C29;
A4-B16-C35;
A4-B16-C41;
A5-B16-C1;
A5-B16-C7;
A5-B16-C13;
A5-B16-C19;
A5-B16-C25;
A5-B16-C31;
A5-B16-C37;
A5-B16-C43;
A6-B16-C3;
A6-B16-C9;
A6-B16-C15;
A6-B16-C21;
A6-B16-C27;
A6-B16-C33;
A6-B16-C39;
A6-B16-C45;
A7-B16-C5;
A7-B16-C11;
A7-B16-C17;
A7-B16-C23;
A7-B16-C29;
A7-B16-C35;
A7-B16-C41;
A8-B16-C1;
A8-B16-C7;
A8-B16-C13;
A8-B16-C19;
A8-B16-C25;
A8-B16-C31;
A8-B16-C37;
A8-B16-C43;
A9-B16-C3;
A9-B16-C9;
A9-B16-C15;
A9-B16-C21;
A9-B16-C27;
A9-B16-C33;
A9-B16-C39;
A9-B16-C45;
A10-B16-C5;
A10-B16Cll;
A2-B16-C14;
A2-B16-C2O;
A2-B16-C26;
A2-B16-C32;
A2-B16-C38;
A2-B16-C44;
A3-B16-C4;
A3-B16-C1O;
A3-B16-C16;
A3-B16-C22;
A3-S16-C28;
A3-B16-C34;
A3-B16-C40;
A3-B16-C46;
A4-E16-C6;
A4-B16-C12;
A4-B16-C18;
A4-B16-C2 4 ;
A4-B16-C30;
A4-B16-C36;
A4-B16-C42;
A5-B16-C2;
A5-BÍ6-C8;
A5-B16-C14 ;
A5-E16-C20;
A5-E16-C26;
A5-E16-C32;
A5-E16-C38;
A5-B16-C44; A6-B16-C4;
A6-E16-C10;
A6-B16-C16;
A6-B16-C22;
A6-B16-C28;
A6-E16-C34;
A6-B16-C40;
A6-E16-C46;
A7-BL5-C6;
A7-B16-C12;
A7-B16-C18;
A7-316-C24;
A7-B16-C30;
A7-B16-C36;
A7-B16-C42;
A8-B16-C2;
A8-B16-C8;
A8-E16-C14;
A8-B16-C20;
A8-B15-C26;
A8-B16-C32;
A8-B16-C38;
A8-B16-C44; A9-B16-C4;
A9-B16-C10;
A9-B16-C16;
A9-B16-C22;
A9-B16-C28;
A9-B16-C34;
A9-BÍ6-C40;
A9-B16-C46;
A10-B16-C6;
A10-B16C12;
115
<td>Α10-Β16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α10-Β16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>Α10-Β16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A1O-B1S-</td>
<td>C25;</td><td>C2 6;</td><td>C2 7;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α10-Β16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α10-Β16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α10-Β16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A10-B16-</td><td>A11-B16-C1;</td><td>A11-B16-C2;</td>
<td>C4 3; A11-B16-C3;</td><td>C4 4; A11-B16-C4;</td><td>C4 5; A11-B16-C5;</td><td>C4 6; A11-B16-C6;</td><td>A11-B16-C7;</td><td>A11-B16-C8;</td>
<td>A11-B16-C9;</td><td>A11-B16-</td><td>Α11-Ξ16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-B15-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>Α11-Β16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-B16-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α11-Β16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-B16-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td><td>C25;</td><td>C2 6;</td>
<td>Α11-Β16-</td><td>A11-B16-</td><td>Α11-Ξ16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-B16-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α11-Β16-</td><td>A11-B16-</td><td>Α11-Ξ16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-BL6-</td>
<td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α11-Β16-</td><td>A11-B16-</td><td>Α11-Ξ16-</td><td>A11-B16-</td><td>A11-B16-</td><td>A11-BL6-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α11-Β16-</td><td>A11-B16-</td><td>A12-316-C1;</td><td>A12-B16-C2;</td><td>A12-B16-C3;</td><td>A12-B16-C4;</td>
<td>C4 5; A12-B16-C5;</td><td>C46; A12-B16-C6;</td><td>A12-316-C7;</td><td>A12-B16-C8;</td><td>A12-B16-C9;</td><td>A12-B16-</td>
<td>Α12-Β16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>C1O; A12-B16-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C2O;</td><td>C21;</td><td>C22;</td>
<td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B1Ó-</td>
<td>C23;</td><td>C2 4 ;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A12-B16-</td><td>A12-B16-</td><td>A12-316-</td><td>A12-B16-</td><td>A12-B15-</td><td>A12-B15-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A12-B16-</td><td>A12-B16-</td><td>A12-316-</td><td>A12-316-</td><td>A12-B16-</td><td>A12-E15-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B16-</td><td>A12-B15-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A13-B16-C1;</td><td>A13-B16-C2;</td><td>A13-B16-C3;</td><td>A13-B16-C4;</td><td>A13-B16-C5;</td><td>A13-Blo-C6;</td>
<td>A13-B16-C7;</td><td>A13-B16-C8;</td><td>A13-B16-C9;</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td>
<td>A13-B16-</td><td>A13-B16-</td><td>Α13-Ξ16-</td><td>C1O; A13-B16-</td><td>Cll; A13-B16-</td><td>C12; A13-B15-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A13-B16-</td><td>A13-B16-</td><td>A13-E16-</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B16-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A13-B16-</td><td>A13-B16-</td><td>A13-316-</td><td>A13-B16-</td><td>A13-B16-</td><td>A13-B15-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A13-B16-</td><td>A13-B16-</td><td>A13-316-</td><td>A13-B16-</td><td>A14-B16-C1;</td><td>A14-B16-C2;</td>
<td>C4 3; A14-B16-C3;</td><td>C4 4; A14-B16-C4;</td><td>C4 5; A14-316-C5;</td><td>C4 6; A14-B16-C6;</td><td>A14-B16-C7;</td><td>A14-B16-C8;</td>
<td>A14-B16-C9;</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B15-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td><td>C2 5;</td><td>C2 6;</td>
116
<td>Α14-Β16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C3O;</td><td>C31;</td><td>C32;</td>
<td>Α14-Β16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td>
<td>C3 3;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α14-Β16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td><td>A14-B16-</td>
<td>C3 9;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α14-Β16-</td><td>A14-B16-</td><td>A15-B16-C1;</td><td>A15-B16-C2;</td><td>A15-B16-C3;</td><td>A15-B16-C4</td>
<td>C4 5; A15-B16-C5;</td><td>C4 6; A15-B16-C6;</td><td>A15-B16-C7;</td><td>A15-B16-C8;</td><td>A15-B16-C9;</td><td>A15-B16-</td>
<td>Α15-Β16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>C1O; A15-B16-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td><td>A15-B16-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A16-B16-C1;</td><td>A16-B16-C2;</td><td>A16-B16-C3;</td><td>A16-B16-C4;</td><td>A16-B16-C5;</td><td>A16-B16-C6</td>
<td>A16-B16-C7 ;</td><td>A16-B16-C8;</td><td>A16-B16-C9;</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td>
<td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>C10; A16-B16-</td><td>Cll; A16-B16-</td><td>C12; A16-B16-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C40;</td><td>C41;</td><td>C4 2;</td>
<td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A16-B16-</td><td>A17-B16-C1;</td><td>A17-B16-C2</td>
<td>C4 3; A17-B16-C3;</td><td>C4 4; A17-B16-C4;</td><td>C4 5; A17-B16-C5;</td><td>C4 6; A17-B16-C6;</td><td>A17-B16-C7;</td><td>A17-B16-C8</td>
<td>A17-B16-C9;</td><td>A17-B16-</td><td>•A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>. C18;</td><td>C19;</td><td>C20;</td>
<td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td><td>C25;</td><td>C26;</td>
<td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-316-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td><td>A17-B16-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A17-B16-</td><td>A17-B16-</td><td>A18-B16-C1;</td><td>A18-B16-C2;</td><td>A18-B16-C3;</td><td>A18-316-C4</td>
<td>C4 5; A18-B16-C5;</td><td>C4 6; A18-B16-C6;</td><td>A18-B16-C7;</td><td>A18-B16-C8;</td><td>A18-B16-C9;</td><td>A18-B16-</td>
<td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>C1O; A18-316-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-316-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A1S-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td>
<td>C23;</td><td>C2 4;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-B16-</td><td>A18-316-</td>
117
C35;
Α18-Β16C41;
A19-B16-C1;
A19-B16-C7;
Α19-Β16C13;
Α19-Β16C19;
Α19-Β16C2 5;
Α19-Β16C31;
Α19-Β16C37;
Α19-Β16C4 3;
A20-B16-C3;
A20-B16-C9;
Α20-Β16C15;
Α20-Β16-,
C21;
Α20-Β16C27;
Α20-Β16C33;
Α20-Β16C3 9;
Α20-Β16C4 5;
A21-B16-C5;
Α21-Β16Cll;
A21-B16C17;
A21-B16C23;
A21-B16C2 9;
A21-B16C35;
A21-B16í'' / .
A22-B16-C1;
A22-B16-C7;
A22-B16C13;
A22-B16C19;
A22-B16C25;
A22-B16C31;
A22-B16C37;
A22-B16C4 3;
A23-B16-C3;
C36;
A18-B16C4 2;
A19-B16-C2;
A19-B16-C8;
A19-B16C14 ;
A19-B16C20;
A19-B16C2 6;
A19-B16C32;
A19-B16C38;
A19-B16C4 4 ;
A20-B16-C4;
A20-B16C10;
A20-B16C16;
A20-B16C22;
A20-B16C28;
A20-B16C34 ;
A20-B16C4O;
A20-B16C4 6;
A21-B16-C6;
A21-B16C12;
A21-B16C18;
A21-B16C2 4;
A21-B16C30;
A21-B16C36;
A21-B16C4 2;
A22-B16-C2.;
A22-B16-C8;
A22-B16C14;
A22-B16C20;
A22-B16C26;
A22-B16C32;
A22-B16C38;
A22-B16C4 4 ;
A23-B16-C4;
C37;
A18-B16C4 3;
A19-B16-C3;
A19-B16-C9;
A19-B16C15;
A19-B16C21;
A19-B16C27;
A19-B16C33;
A19-B16C3 9;
A19-B16C4 5;
A20-B16-C5;
A20-B16Cll;
A20-B16C17;
A20-B16C2 3;
A20-B16C2 9;
A20-B16C35;
A20-B16C41;
A21-B16-C1;
A21-B16-C7;
A21-B16C13;
A21-B16C19;
A21-B16C25;
A21-B16C31
A21-B16C37;
A21-B16C4 3;
A22-B16-C3;
A22-B16-C9;
A22-B16C15;
A22-B16C21;
A22-B16C27;
A22-B16C33;
A22-B16C39;
A22-B16C4 5;
A23-B16-C5;
C38;
A18-B16C4 4;
A19-B16-C4;
A19-B16C1O;
A19-B16C16;
A19-B16C22;
A19-B16C28;
A19-B16C34 ;
A19-B16C4O;
A19-B16C4 6;
A20-B16-C6;
A20-B16C12;
A20-B16C18;
A20-B16C24;
A20-B16C30;
A2O-B16C3 6; ·
A20-B16C4 2;
A21-B16-C2;
A21-B16-C8;
A21-B16C14;
A21-B16C2O;
A21-B16C2 6;
A21-B16C32;
A21-B16C38;
A21-B16C4 4;
A22-B16-C4;
A22-B16C1O;
A22-B16C16;
A22-B16C22;
A22-B16C28;
A22-B16C34;
A22-B16C4O;
A22-B16C46;
A23-B16-C6;
C39;
A18-B16C4 5;
A19-B16-C5;
A19-B16Cll;
A19-B16C17;
A19-B16C23;
A19-B16C2 9;
A19-B16C35;
A19-B16C41;
A20-B16-C1;
A20-B16-C7;
A20-B16C13;
A20-B16C19;
A20-B16C25;
A20-B16C31;
A20-B16C37;
A20-B16C4 3;
A21-B16-C3;
A21-B16-C9;
A21-B16C15 ;
A21-B16C21;
A21-B16C27;
A21-B16C33;
A21-B16C39;
A21-B16C4 5;
A22-B16-C5;
A22-B16Cll;
A22-B16C17;
A22-B16C23;
A22-B16C2 9;
A22-B16C35;
A22-B16C41;
A23-B16-C1;
A23-B16-C7;
C4O;
A18-B16C4 6;
A19-B16-C6;
A19-B16C12;
A19-B16C18;
A19-B16C24;
A19-B16C30;
A19-B16C36;
A19-B16C4 2;
A20-B16-C2;
A20-B16-C8;
A20-B16C14 ;
A20-B16C20;
A20-B1ÓC2 6;
A20-B16C32;
A20-B16C38;
A20-B16C4 4;
A21-31o-C4;
A21-3-6C1O;
A21-51CC16;
A21-B16C22;
A21-B16C28;
A21-316C34;
A21-EÍCC4O;
A21-B16C4 6;
A22-B16-C6;
A22-B16C12;
A22-B16C18;
Α22-Ξ16C24;
A22-B1SC30;
A22-BÍCC36;
A22-B15C4 2;
A23-B16-C2;
A23-B16-C8;
118
<td>A23-B16-C9;</td><td>A23-B16- C10;</td><td>A23-B16Cll;</td><td>A23-B16- C12;</td><td>A23-B16- C13;</td><td>A23-B16- C14;</td>
<td>Α23-Β16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α23-Β16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α23-Β16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α23-ΒΙ6-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-.</td><td>A23-B16-</td><td>A23-B16-</td>
<td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α23-Β16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td><td>A23-B16-</td><td>Α23-Ξ16-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C44 ;</td>
<td>Α23-Β16-</td><td>A23-B16-</td><td>A24-B16-C1;</td><td>A24-B16-C2;</td><td>A24-B16-C3;</td><td>A24-516-C4;</td>
<td>C4 5; A24-B16-C5;</td><td>C4 6; A24-B16-C6;</td><td>A24-B16-C7;</td><td>A24-B16-C8;</td><td>A24-B16-C9;</td><td>A24-E16-</td>
<td>Α24-Β16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>C1O; A24-B16-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>Α24-Ξ1δ-</td>
<td>C2 3;</td><td>C2 4 ;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C2 8;</td>
<td>Á24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-BB6-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>Α24-Ξ16-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A24-B16-</td><td>A24-B16-</td><td>1 A24-B16-</td><td>A24-B16-</td><td>A24-B16-</td><td>A24-ELS-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A25-B16-C1;</td><td>A25-B16-C2;</td><td>A25-B16-C3;</td><td>A25-B16-C4;</td><td>A25-B16-C5;</td><td>A25-B16-C6;</td>
<td>A25-B16-C7;</td><td>A25-B16-C8;</td><td>A25-B16-C9;</td><td>A25-B16-</td><td>A25-B16-</td><td>Α25-Ξ15-</td>
<td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>C1O; A25-B16-</td><td>Cll ; A25-B16-</td><td>C12; A25-516-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>Α25-Ξ15-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35 ;</td><td>C36;</td>
<td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-ELÓ-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A25-B16-</td><td>A26-B16-C1;</td><td>A26-E16-C2;</td>
<td>C4 3; A26-B16-C3;</td><td>C4 4 ; A26-B16-C4;</td><td>C4 5; A26-B16-C5;</td><td>C4 6; A26-B16-C6;</td><td>A26-B16-C7;</td><td>A26-B16-C8;</td>
<td>A26-B16-C9;</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>Α26-Ξ16-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>Α26-Ξ16-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B1Ó-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C26;</td>
<td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-BB6-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td><td>A26-B16-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A26-B16-</td><td>A26-B16-</td><td>A27-B16-C1;</td><td>A27-B16-C2;</td><td>A27-B16-C3;</td><td>A27-BLÓ-C4;</td>
<td>C4 5; A27-B16-C5;</td><td>C4 6; A27-B16-C6;</td><td>A27-B16-C7;</td><td>A27-B16-C8;</td><td>A27-B16-C9;</td><td>A27-E'-c-</td>
<td>A27-B16-</td><td>A27-B16-</td><td>A27-B16-</td><td>A27-B16-</td><td>A27-B16-</td><td>C1O; A27-B16-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A27-B16-</td><td>A27-B16-</td><td>A27-B16-</td><td>A27-B16-</td><td>A27-B16-</td><td>A27-B16-</td>
119
C17;
Α27-Β16C2 3;
Α27-Β16C2 9;
Α27-Β16C35;
Α27-Β16C41;
A28-B16-C1;
A28-B16-C7;
Α28-Β16C13;
Α28-Β16C19;
Α28-Β16C2 5;
Α28-Β16C31;
Α28-Β16C37;
Α28-Β16C4 3;
A1-B17-C3;
A1-B17-C9;
A1-B17-C15;
A1-B17-C21;
A1-B17-C27;
A1-B17-C33;
A1-B17-C39;
A1-B17-C45;
A2-B17-C5;
A2-B17-C11;
A2-B17-C17;
A2-B17-C23;
A2-B17-C29;
A2-B17-C35;
A2-B17-C41;
A3-B17-C1;
A3-B17-C7;
A3-B17-C13;
A3-B17-C19;
A3-B17-C25;
A3-B17-C31;
A3-B17-C37;
A3-B17-C43;
A4-B17-C3;
A4-B17-C9;
A4-B17-C15;
A4-B17-C21;
A4-B17-C27;
A4-B17-C33;
A4-B17-C39;
A4-B17-C45;
A5-B17-C5;
A5-B17-C11;
A5-B17-C17;
A5-B17-C23;
A5-B17-C29;
A5-B17-C35;
A5-B17-C41;
A6-B17-C1;
C18;
Α27-Β16C24;
Α27-Β16C30;
Α27-Β16C36 ;
Α27-Β16C4 2;
A28-B16-C2;
A28-B16-C8;
Α28-Β16C14;
Α28-Β16C20;
Α28-Β16C2 6;
Α28-Β16C32;
Α28-Β16C38;
Α28-Β16C4 4;
A1-B17-C4;
A1-B17-C10;
A1-B17-C16;
A1-B17-C22;
A1-B17-C28;
A1-B17-C34;
A1-B17-C40;
A1-B17-C46; A2-B17-C6;
A2-B17-C12;
A2-B17-C18;
A2-B17-C24;
A2-B17-C30;
A2-B17-C36;
A2-B17-C42;
A3-B17-C2;
A3-B17-C8;
A3-B17-C14;
A3-B17-C20;
A3-B17-C26;
A3-B17-C32;
A3-B17-C38;
A3-B17-C44;
A4-B17-C4; ·
A4-B17-C10;
A4-B17-C16;
A4-B17-C22;
A4-B17-C28;
A4-B17-C34; A4-B17-C40; A4-B17-C46;
A5-B17-C6;
A5-B17-C12;
A5-B17-C18;
A5-B17-C24;
A5-B17-C30;
A5-B17-C36;
A5-B17-C42; A6-B17-C2;
C19;
Α27-Β16C25;
Α27-Β16C31;
Α27-Β16C37;
Α27-Β16C4 3;
A28-B16-C3;
A28-B16-C9;
Α28-Β16C15;
Α28-Β16C21;
Α28-Β16C27;
Á28-B16C33;
Α28-Β16C39;
Α28-Β16C4 5;
A1-B17-C5;
A1-B17-C11;
A1-B17-C17;
A1-B17-C23;
A1-B17-C29;
A1-B17-C35;
A1-B17-C41;
A2-B17-C1;
A2-B17-C7;
A2-B17-C13;
A2-B17-C19;
A2-B17-C25;
A2-B17-C31;
A2-B17-C37;
A2-B17-C43;
A3-B17-C3;
A3-B17-C9;
A3-B17-C15;
A3-B17-C21;
A3-B17-C27;
A3-B17-C33;
A3-B17-C39;
A3-B17-C45;
A4-B17-C5;
A4-B17-C11;
A4-B17-C17;
A4-B17-C23;
A4-B17-C29;
A4-B17-C35;
A4-B17-C41;
A5-B17-C1;
A5-B17-C7;
A5-B17-C13;
A5-B17-C19;
A5-B17-C25;
A5-B17-C31;
A5-B17-C37;
A5-B17-C43;
A6-B17-C3;
C20;
Α27-Β16C2 6;
Α27-Β16C32;
Α27-Β16C38;
Α27-Β16C4 4;
A28-B16-C4;
A28-BÍ6C10;
A28-B16C16;
A28-B16C22;
A28-B16C28;
A28-B16C34;
A28-B16C4O;
A28-B16C4 6;
A1-B17-C6;
A1-B17-C12;
A1-B17-C18;
A1-B17-C24;
A1-B17-C30;
A1-B17-C36;
A1-B17-C42;
A2-B17-C2;
A2-B17-C8;
A2-B17-C14;
A2-B17-C2O;
A2-B17-C26;
A2-B17-C32;
A2-B17-C38;
A2-B17-C44;
A3-B17-C4;
A3-B17-C10;
A3-B17-C16;
A3-B17-C22;
A3-B17-C28;
A3-B17-C34;
A3-B17-C40;
A3-B17-C46;
A4-B17-C6;
A4-B17-C12;
A4-B17-C18;
A4-B17-C24;
A4-B17-C30;
A4-B17-C36;
A4-B17-C42;
A5-B17-C2;
A5-B17-C8;
A5-B17-C14;
A5-B17-C20;
A5-B17-C26;
A5-B17-C32;
A5-B17-C38;
A5-B17-C44;
A6-B17-C4;
C21;
A27-B16C27;
A27-B16C33;
A27-B16C39;
A27-B16C4 5;
A28-B16-C5;
A28-B16Cll;
A28-B16C17;
A28-B16C23;
A28-B16C2 9;
A28-B16C35;
A28-B16C41;
A1-B17-C1;
A1-B17-C7;
A1-B17-C13;
A1-B17-C19;
A1-B17-C25;
A1-B17-C31;
A1-B17-C37;
A1-B17-C43;
A2-B17-C3;
A2-B17-C9;
A2-B17-C15;
A2-B17-C21;
A2-B17-C27;
A2-B17-C33;
A2-B17-C39;
A2-B17-C45;
A3-B17-C5;
A3-B17-C11;
A3-B17-C17;
A3-B17-C23;
A3-B17-C29;
A3-B17-C35;
A3-B17-C41;
A4-B17-C1;
A4-B17-C7;
A4-B17-C13;
A4-B17-C19;
A4-B17-C25;
A4-B17-C31;
A4-B17-C37;
A4-B17-C43;
A5-B17-C3;
A5-B17-C9;
A5-B17-C15;
A5-B17-C21;
A5-B17-C27;
A5-B17-C33;
A5-B17-C39;
A5-B17-C45;
A6-B17-C5;
C22;
A27-B16C28;
A27-B16C34 ;
A27-B16C 4 O ;
Α27-Ξ1ΟC4 6;
A28-B16-C6;
Α28-Ξ16C12;
A28-B-6C18;
Α28-Ξ16C2 4 ;
A28-B3ÓC30;
Α28-Ξ16C36;
Α28-Ξ16C4 2;
A1-317-C2;
A1-B1-C8;
A1-B17-C14;
Al-=l-C20;
Al-3'_-C26;
A1-337-C32;
A1-B3--C38;
Al-3'.<sup>_</sup>-C4 4;
A2-Bľ-C4;
A2-B17-C10;
A2-B17-C16;
A2-B1'-C22;
A2-31‘-C28;
A2-B1-C34;
A2-Bl-C40;
A2-317-C46;
A3-B1~-C6;
Α3-Ξ1-C12;
A3-B1’-C18;
A3-B17-C24;
A3-=l*-C30;
A3-B17-C36;
A3-3ľ’-C42;
A4-31-C2;
A4-B1-C8;
A4-B1-C14;
A4-317-C20;
A4-31-02 6,A4-317-C32;
A4-3ľ-C38;
A4-31’’-C44 ;
A5-B1’-C4;
A5-317-C10;
A5-B17-C16;
A5-317-C22;
A5-317-C28;
A5-B17-C34;
A5-317-C40;
A5-B17-C46;
A6-B1~-C6;
120
<td>A6-B17-C7;</td><td>A6-B17-C8;</td><td>A6-B17-C9;</td><td>A6-B17-C10;</td><td>A6-B17-C11;</td><td>A6-B17-C12;</td>
<td>A6-B17-C13;</td><td>A6-B17-C14;</td><td>A6-B17-C15;</td><td>A6-B17-C16;</td><td>A6-B17-C17;</td><td>A6-B17-C18;</td>
<td>A6-B17-C19;</td><td>A6-B17-C20;</td><td>A6-B17-C21;</td><td>A6-B17-C22;</td><td>A6-B17-C23;</td><td>A6-B17-C24;</td>
<td>A6-B17-C25;</td><td>A6-B17-C26;</td><td>A6-B17-C27;</td><td>A6-B17-C28;</td><td>A6-B17-C29;</td><td>A6-B17-C30;</td>
<td>A6-B17-C31;</td><td>A6-B17-C32;</td><td>A6-B17-C33;</td><td>A6-B17-C34;</td><td>A6-B17-C35;</td><td>A6-B17-C36;</td>
<td>A6-B17-C37;</td><td>A6-B17-C38;</td><td>A6-B17-C39;</td><td>A6-B17-C40;</td><td>A6-B17-C41;</td><td>A6-B1-C42;</td>
<td>A6-B17-C43;</td><td>A6-B17-C44;</td><td>A6-B17-C45;</td><td>A6-B17-C46;</td><td>A7-B17-C1;</td><td>A7-B17-C2;</td>
<td>A7-B17-C3;</td><td>A7-B17-C4;</td><td>A7-B17-C5;</td><td>A7-B17-C6;</td><td>A7-B17-C7;</td><td>A7-B17-C8;</td>
<td>A7-B17-C9;</td><td>A7-B17-C10;</td><td>A7-B17-C11;</td><td>A7-B17-C12;</td><td>A7-B17-C13;</td><td>A7-Bľ-C14;</td>
<td>A7-B17-C15;</td><td>A7-B17-C16;</td><td>A7-B17-C17;</td><td>A7-B17-C18;</td><td>A7-B17-C19;</td><td>A7-Bl-C20;</td>
<td>A7-B17-C21;</td><td>A7-B17-C22;</td><td>A7-B17-C23;</td><td>A7-B17-C24;</td><td>A7-B17-C25;</td><td>A7-B1=-C26;</td>
<td>A7-B17-C27;</td><td>A7-B17-C28;</td><td>A7-B17-C29;</td><td>A7-B17-C30;</td><td>A7-B17-C31;</td><td>A7-BO-C32;</td>
<td>A7-B17-C33;</td><td>A7-B17-C34;</td><td>A7-B17-C35;</td><td>A7-B17-C36;</td><td>A7-B17-C37;</td><td>A7-B1<sup>-</sup>-C38;</td>
<td>A7-B17-C39;</td><td>A7-B17-C40;</td><td>A7-B17-C41;</td><td>A7-B17-C42;</td><td>A7-B17-C43;</td><td>A7-Bľ-C44 ;</td>
<td>A7-B17-C45;</td><td>A7-B17-C46;</td><td>A8-B17-C1;</td><td>A8-B17-C2;</td><td>AS-B17-C3;</td><td>A8-B1’-C4;</td>
<td>A8-B17-C5;</td><td>A8-B17-C6;</td><td>A8-B17-C7;</td><td>A8-B17-C8;</td><td>A8-B17-C9;</td><td>A8-B1=-C1O;</td>
<td>A8-B17-C11;</td><td>A8-B17-C12;</td><td>A8-B17-C13;</td><td>A8-B17-C14;</td><td>A8-B17-C15;</td><td>A8-B1-C16;</td>
<td>A8-B17-C17;</td><td>A8-B17-C18;</td><td>A8-B17-C19;</td><td>A8-B17-C20;</td><td>A8-B17-C21;</td><td>A8-B1-C22;</td>
<td>A8-B17-C23;</td><td>A8-B17-C24;</td><td>A8-B17-C25;</td><td>A8-B17-C26;</td><td>A8-B17-C27;</td><td>A8-B1'-C28;</td>
<td>A8-B17-C29;</td><td>A8-B17-C30;</td><td>A8-B17-C31;</td><td>A8-B17-C32;</td><td>A8-B17-C33;</td><td>A8-B1'-C34;</td>
<td>A8-B17-C35;</td><td>A8-B17-C36;</td><td>A8-B17-C37;</td><td>A8-B17-C38;</td><td>A8-B17-C39;</td><td>A8-B1’-C4O;</td>
<td>A8-B17-C41;</td><td>A8-B17-C42;</td><td>A8-B17-C43;</td><td>A8-B17-C44;</td><td>A8-B17-C45;</td><td>A8-B1“-C46;</td>
<td>A9-B17-C1;</td><td>A9-B17-C2;</td><td>A9-B17-C3;</td><td>A9-B17-C4;</td><td>A9-B17-C5;</td><td>A9-B1’-C6;</td>
<td>A9-B17-C7;</td><td>A9-B17-C8;</td><td>A9-B17-C9;</td><td>A9-B17-C10;</td><td>A9-B17-C11;</td><td>A9-B1-C12;</td>
<td>A9-B17-C13;</td><td>A9-B17-C14;</td><td>A9-B17-C15;</td><td>A9-B17-C16;</td><td>A9-B17-C17;</td><td>A9-B17-C18;</td>
<td>A9-B17-C19;</td><td>A9-B17-C20;</td><td>A9-B17-C21;</td><td>A9-B17-C22;</td><td>A9-B17-C23;</td><td>A9-B1“-C24;</td>
<td>A9-B17-C25;</td><td>A9-B17-C26;</td><td>A9-B17-C27;</td><td>A9-B17-C28;</td><td>A9-B17-C29;</td><td>A9-Bl-C30;</td>
<td>A9-B17-C31;</td><td>A9-B17-C32;</td><td>A9-B17-C33;</td><td>A9-B17-C34;</td><td>A9-B17-C35;</td><td>A9-B1-C36;</td>
<td>A9-B17-C37;</td><td>A9-B17-C38;</td><td>A9-B17-C39;</td><td>A9-B17-C40;</td><td>A9-B17-C41;</td><td>A9-B1-C42;</td>
<td>A9-B17-C43;</td><td>A9-B17-C44;</td><td>A9-B17-C45;</td><td>A9-B17-C46;</td><td>A10-B17-C1;</td><td>A10-E1--C2;</td>
<td>A10-B17-C3;</td><td>A10-B17-C4;</td><td>A10-B17-C5;</td><td>A10-B17-C6;</td><td>A10-B17-C7;</td><td>A1O-E1=-C8;</td>
<td>A10-B17-C9;</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>AlO-Bľ-</td>
<td>Α10-Β17-</td><td>C10; A10-B17-</td><td>Cll; A10-B17-</td><td>02; A10-B17-</td><td>0 3; A10-B17-</td><td>C14; A10-B1·-</td>
<td> 05;</td><td> 0 6;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α10-Β17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-E1-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α10-Β17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-E17-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α10-Β17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>AlO-Bľ-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α10-Β17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-B17-</td><td>A10-BL7-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α10-Β17-</td><td>A10-B17-</td><td>A11-B17-C1;</td><td>A11-B17-C2;</td><td>A11-B17-C3;</td><td>A11-EH-C4;</td>
<td>C4 5; A11-B17-C5;</td><td>C4 6; A11-B17-C6;</td><td>A11-B17-C7;</td><td>A11-B17-C8;</td><td>A11-B17-C9;</td><td>All-Bl·’-</td>
<td>Α11-Β17- <sup>1</sup></td><td>A11-B17- .</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>C1C; All-Bľ-</td>
<td>Cll;</td><td>C12;</td><td> 03;</td><td>C14;</td><td>Cl:;</td><td>C16;</td>
<td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>All-Bl'-</td>
<td>C17;</td><td>C18;</td><td> 0 9;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>All-Bl·’-</td>
<td>C23;</td><td>C2 4;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>All-Bl·’-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C3 9;</td><td>C4 0;</td>
<td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>A11-B17-</td><td>All-Bl<sup>-</sup>-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A12-B17-C1;</td><td>A12-B17-C2;</td><td>A12-B17-C3;</td><td>A12-B17-C4;</td><td>A12-B17-C5;</td><td>A12-B17-C6;</td>
<td>A12-B17-C7;</td><td>A12-B17-C8;</td><td>A12-B17-C9;</td><td>A12-B17-</td><td>A12-B17-</td><td>A12-BĽ-</td>
<td>A12-B17-</td><td>A12-B17-</td><td>A12-B17-</td><td>C10; A12-B17-</td><td>Cll; A12-B17-</td><td>C12; A12-B1<sup>-</sup>-</td>
121
C13;
Α12-Β17C19;
Α12-Β17C25;
Α12-Β17C31;
Α12-Β17C37;
Α12-Β17C4 3;
A13-B17-C3;
A13-B17-C9;
Α13-Β17C15;
Α13-Β17C21;
Α13-Β17C27;
Α13-Β17C33;
Α13-Β17C39;
Α13-Β17C4 5;
A14-B17-C5;
Α14-Β17Cll;
A14-B17C17;
A14-B17C23;
A14-B17C29;
A14-B17C35;
A14-B17C41;
A15-B17-C1;
A15-B17-C7;
A15-B17C13;
A15-B17C19;
A15-B17C2 5;
A15-B17C31;
A15-B17C37;
A15-B17C4 3;
A16-B17-C3;
A16-B17-C9;
A16-B17C15;
A16-B17C21;
A16-B17C14;
A12-B17C20;
A12-B17C2 6;
A12-B17C32;
A12-B17C38;
A12-B17C4 4;
A13-B17-C4;
A13-B17C10;
A13-B17C16;
A13-B17C22;
A13-B17C28;
A13-B17C34;
A13-B17C4O;
A13-B17C4 6;
A14-B17-C6;
A14-B17C12;
A14-B17C18;
A14-B17C2 4;
A14-B17C30;
A14-B17C36;
A14-B17C4 2;
A15-B17-C2;
A15-B17-C8;
A15-B17C14;
A15-B17C20;
A15-B17C2 6;
A15-B17C32;
A15-B17C38;
A15-B17C4 4;
A16-B17-C4;
A16-B17C1O;
A16-B17C16;
A16-B17C22;
A16-B17C15;
A12-B17C21;
A12-B17C27;
A12-B17C33;
A12-B17C39;
A12-B17C4 5;
A13-B17-C5;
A13-B17Cll;
A13-B17C17;
A13-B17C23;
A13-B17C2 9;
A13-B17C35;
A13-B17C41;
A14-B17-C1;
A14-B17-C7;
A14-B17C13;
A14-B17C19;
A14-B17C25;
A14-B17C31;
A14-B17C37;
A14-B17C4 3;
A15-B17-C3;
A15-B17-C9;
A15-B17C15;
A15-B17C21;
A15-B17C27;
A15-B17C33;
A15-B17C39;
A15-B17C4 5;
A16-B17-C5;
A16-B17Cll;
A16-B17C17;
A16-B17C23;
A16-B17C16;
A12-B17C22;
A12-B17C28;
A12-B17C34 ;
A12-B17C4O;
A12-B17C4 6;
A13-B17-C6;
A13-B17C12;
A13-B17C18;
A13-B17C24;
A13-B17C30;
A13-B17C36;
A13-B17C4 2;
A14-B17-C2;
A14-B17-C8;
A14-B17C14;
A14-B17C20;
A14-B17C2 6;
A14-B17C32;
A14-B17C38;
A14-B17C4 4;
A15-B17-C4;
A15-B17C1O;
A15-B17C16;
A15-B17C22;
A15-B17C28;
A15-B17C34;
A15-B17C4O;
A15-B17C4 6;
A16-B17-C6;
A16-B17C12;
A16-B17C18;
A16-B17C24;
A16-B17C17;
A12-B17C23;
A12-B17C29;
A12-B17C35;
A12-B17C41;
A13-B17-C1;
A13-B17-C7;
A13-B17C13;
A13-B17C19;
A13-B17C25;
A13-B17C31;
A13-B17C37;
A13-B17C43;
A14-B17-C3;
A14-B17-C9;
A14-B17C15;
A14-B17C21;
A14-B17C27;
A14-B17C33;
A14-B17C39;
A14-B17C4 5;
A15-B17-C5;
A15-B17Cll;
A15-B17C17;
A15-B17C23;
A15-B17C29;
A15-B17C35;
A15-B17C41;
A16-B17-C1;
A16-B17-C7;
A16-B17C13;
A16-B17C19;
A16-B17C25;
A16-B17C18;
A12-B17C24 ;
A12-B17C30;
A12-B17C3 6;
A12-317C4 2;
A13-317-C2;
A13-317-C8;
A13-B17C14 ;
A13-B17C20;
A13-B17C2 6;
Α13-Ξ17C32;
Α13-Ξ17C38;
A13-317C4 4;
A14-517-C4;
Α14-Ξ17C1O;
Α14-Ξ17C16;
A14-B17C22;
Α14-Ξ17C28;
Α14-Ξ17C34;
Α14-Ξ17C4O;
Α14-Ξ17C4 6;
A15-317-C6;
Α15-Ξ17C12;
Α15-Ξ17C18;
Α15-Ξ17C2 4;
A15-317C30;
A15-B17C36;
A15-B17C4 2;
A16-317-C2;
A16-B17-C8;
Α16-Ξ17C14;
A16-E17C20;
Α16-Ξ17C2 6;
A16-B17122
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α16-Β17-</td><td>A16-B17-</td><td>A16-B17-</td><td>A16-B17-</td><td>A16-B17-</td><td>A16-B17-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α16-Β17-</td><td>A16-B17-</td><td>A16-B17-</td><td>A16-B17-</td><td>A16-B17-</td><td>A16-B17-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α16-Β17-</td><td>A16-B17-</td><td>A17-B17-Cl;</td><td>A17-B17-C2;</td><td>A17-B17-C3;</td><td>A17-B17-C4;</td>
<td>C4 5; A17-B17-C5;</td><td>C4 6; A17-B17-C6;</td><td>A17-B17-C7;</td><td>A17-B17-C8;</td><td>A17-B17-C9;</td><td>A17-B17-</td>
<td>Α17-Β17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>C1O; A17-B17-</td>
<td>Cll; <sup>1</sup></td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td>
<td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td><td>A17-B17-</td>
<td>C41;</td><td>C42;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A18-B17-C1;</td><td>A18-B17-C2;</td><td>A18-B17-C3;</td><td>A18-B17-C4;</td><td>A18-B17-C5;</td><td>A18-B17-C6;</td>
<td>A18-B17-C7;</td><td>A18-B17-C8;</td><td>A18-B17-C9;</td><td>A18-B17-</td><td>A1S-B17-</td><td>A18-B17-</td>
<td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>C1O; A1S-B17-</td><td>Cll; A18-B17-</td><td>C12; ,A18-B17-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>. C16;</td><td>C17;</td><td>C18;</td>
<td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A18-B17-</td><td>A19-B17-C1;</td><td>A19-B17-C2;</td>
<td>C4 3; A19-B17-C3;</td><td>C4 4; A19-B17-C4;</td><td>C4 5; A19-B17-C5;</td><td>C4 6; A19-B17-C6;</td><td>A19-B17-C7;</td><td>A19-B17-C8;</td>
<td>A19-B17-C9;</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12 ;</td><td>C13;</td><td>' C14;</td>
<td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C1S;</td><td>C19;</td><td>C20;</td>
<td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td><td>A19-B17-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A19-B17-</td><td>A19-B17-</td><td>A20-B17-C1;</td><td>A20-B17-C2;</td><td>A20-B17-C3;</td><td>A20-B17-C4;</td>
<td>C4 5; A20-B17-C5;</td><td>C4 6; A20-B17-C6;</td><td>A20-B17-C7;</td><td>A20-B17-C8;</td><td>A20-B17-C9;</td><td>A20-B17-</td>
<td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>C1O; A20-B17-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A20-B17-</td><td>A20-B17-</td><td>A20-E17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td><td>A20-B17-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
123
Α20-Β17C41;
A21-B17-C1;
A21-B17-C7;
Α21-Β17C13;
Α21-Β17C19;
Α21-Β17C25;
Α21-Β17C31;
Α21-Β17C37;
Α21-Β17C4 3;
A22-B17-C3;
A22-B17-C9;
Α22-Β17C15;
Α22-Β17C21;
Α22-Β17C27;
Α22-Β17C33;
Α22-Β17C39;
Α22-Β17C4 5; A23-B17-C5;
Α23-Β17Cll;
A23-B17C17;
A23-B17C2 3;
A23-B17C2 9;
A23-B17C35;
A23-B17C41;
A24-B17-C1;
A24-B17-C7;
A24-B17C13;
A24-B17C19;
A24-B17C25;
A24-B17C31;
A24-B17C37;
A24-B17C4 3;
A25-B17-C3;
A25-B17-C9;
A20-B17C4 2;
A21-B17-C2;
A21-B17-C8;
A21-B17C14 ;
A21-B17C20;
A21-B17C2 6;
A21-B17C32;
A21-B17C38;
A21-B17C4 4;
A22-B17-C4;
A22-B17- '
C10;
A22-B17C16;
A22-B17C22;
A22-B17C28;
A22-B17C34;
A22-B17C4O;
A22-B17C4 6;
A23-B17-C6;
A23-B17C12;
A23-B17C18;
A23-B17C2 4;
A23-B17C30;
A23-B17C36;
A23-B17C4 2;
A24-B17-C2;
A24-B17-C8;
A24-B17C14;
A24-B17C20;
A24-B17C2 6;
A24-B17C32;
A24-B17C38;
A24-B17C4 4 ;
A25-B17-C4; A25-B17A20-B17C4 3;
A21-B17-C3;
A21-B17-C9;
A21-B17C15;
A21-B17C21;
A21-B17C27;
A21-B17C33;
A21-B17C39;
A21-B17C4 5;
A22-B17-C5; A22-B17Cll;
A22-B17C17;
A22-B17C23;
A22-B17C2 9;
A22-B17C35;
A22-B17C41;
A23-B17-C1;
A23-B17-C7;
A23-B17C13;
A23-B17C19;
A23-B17C2 5;
A23-B17C31;
A23-B17C37;
A23-B17C4 3;
A24-B17-C3;
A24-B17-C9;
A24-B17C15;
A24-B17C21;
A24-B17C27;
A24-B17C33;
A24-B17C39;
A24-B17C4 5;
A25-B17-C5;
A25-B17A20-B17C4 4;
A21-B17-C4;
A21-B17C1O;
A21-B17C16;
A21-B17C22;
A21-B17C28;
A21-B17C34;
A21-B17C4O;
A21-B17C4 6;
A22-B17-C6;
A22-B17C12;
A22-B17C18 ;
A22-B17C2 4;
A22-B17C30;
A22-B17C36;
A22-B17C4 2;
A23-B17-C2;
A23-B17-C8;
A23-B17C14;
A23-B17C20;
A23-B17C2 6;
A23-B17C32;
A23-B17C38;
A23-B17C4 4;
A24-B17-C4;
A24-B17C1O;
A24-B17C16;
A24-B17C22;
A24-B17C28;
A24-B17C34 ;
A24-B17C4O;
A24-B17C4 6;
A25-B17-C6;
A25-B17A20-B17C4 5; A21-B17-C5;
A21-B17Cll;
A21-B17C17;
A21-B17C23;
A21-B17C29;
A21-B17C35;
A21-B17C41;
A22-B17-C1;
A22-B17-C7;
A22-B17C13;
A22-B17C19;
A22-B17C25;
A22-B17,C3i;
A22-B17C37;
A22-B17C4 3;
A23-B17-C3;
A23-B17-C9;
A23-317C15;
A23-B17C21;
A23-B17C27;
Ά23-Β17C33;
A23-B17C39;
A23-B17C4 5;
A24-B17-C5;
A2 4-317Cll;
A24-B17C17;
A24-B17C23;
A24-B17C29;
A24-B17C35;
A24-317C41;
A25-B17-C1;
A25-B17-C7;
A25-317A20-B17C4 6; A21-B17-C6;
A21-B17C12;
A21-B17C18;
A21-B17C24;
A21-B17C30; '
A21-B17C36;
A21-B17C4 2;
A22-B17-C2;
A22-B17-C8;
A22-B17C14;
A22-B17C20;
A22-B17C26;
A22-E17C32;
A22-E17C38;
A22-E17C4 4;
A23-E17-C4;
A23-E17C10;
A23-B17C16;
A23-B17C22;
A23-E17C2 8;
A23-B17C34;
A23-B17C4O;
A23-B17C4 6;
A24-E17-C6;
A24-B17C12;
A24-B17C18;
A24-B17C24;
A24-B17C30;
A24-B17C36;
A24-B17C4 2;
A25-B17-C2;
A25-B17-C8;
A25-B17124
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td></td>
<td>Α25-Β17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17</td><td> -</td>
<td>C15 ;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td></td>
<td>Α25-Β17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17</td><td> -</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td></td>
<td>Α25-Β17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-317</td><td> -</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td></td>
<td>Α25-Β17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-317</td><td> -</td>
<td>C33;</td><td>C34;</td><td>. C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td></td>
<td>Α25-Β17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17-</td><td>A25-B17</td><td> -</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td></td>
<td>Α25-Β17-</td><td>A25-B17-</td><td>A26-B17-C1;</td><td>A26-B17-C2;</td><td>A26-E17-C3;</td><td>A26-317</td><td>-C4;</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td><td></td>
<td>A26-B17-C5;</td><td>A26-B17-C6;</td><td>A26-317-C7;</td><td>A26-B17-C8;</td><td>A26-B17-C9;</td><td>Α26-Ξ17</td><td> -</td>
<td></td><td></td><td></td><td></td><td></td><td>C1O;</td><td></td>
<td>Α26-Β17-</td><td>A26-B17-</td><td>A26-B17-</td><td>Ά26-Β17-</td><td>A26-B17-</td><td>Α26-Ξ17</td><td> -</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td><td></td>
<td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>Α26-Ξ17</td><td> -</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td></td>
<td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17</td><td> -</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td></td>
<td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>Α26-Ξ17</td><td> -</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td></td>
<td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>Α26-Ξ17</td><td> -</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td></td>
<td>A26-B17-</td><td>A26-B17-</td><td>A26.-B17-</td><td>A26-B17-</td><td>A26-B17-</td><td>.Α26-Ξ17</td><td> -</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td>
<td>A27-B17-C1;</td><td>A27-B17-C2;</td><td>A27-B17-C3;</td><td>A27-B17-C4;</td><td>A27-B17-C5;</td><td>A27-B17</td><td>-C6;</td>
<td>A27-B17-C7;</td><td>A27-B17-C8;</td><td>A27-B17-C9;</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-B17</td><td> -</td>
<td></td><td></td><td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td></td>
<td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>Ά27-Ξ17</td><td> -</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td></td>
<td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>Α27-ΒΪ7-</td><td>A27-B17-</td><td>Α27-Ξ17</td><td> -</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td><td></td>
<td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-32></td><td> -</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td></td>
<td>A27-B17-</td><td>A27-B17-</td><td>A27-B17- </td><td>A27-B17-</td><td>A27-B17-</td><td>A27-E17</td><td> -</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td></td>
<td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-E17</td><td> -</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td></td>
<td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A27-B17-</td><td>A28-B17-C1;</td><td>A28-B17</td><td>-C2;</td>
<td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td>
<td>A28-B17-C3;</td><td>A28-B17-C4;</td><td>A28-B17-C5;</td><td>A28-B17-C6;</td><td>A28-B17-C7;</td><td>Α28-Ξ1</td><td>-C8;</td>
<td>A2S-B17-C9;</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-E17-</td><td>Α28-Ξ17</td><td> -</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td></td>
<td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17</td><td> -</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td></td>
<td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17</td><td> -</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td></td>
<td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17</td><td> -</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td></td>
<td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>Α28-Ξ17</td><td> -</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td></td>
<td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B17-</td><td>A28-B1</td><td> -</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td></td>
<td>A28-B17-</td><td>A28-B17-</td><td>A1-B18-C1;</td><td>A1-B18-C2;</td><td>A1-B18-C3;</td><td>A1-B13-</td><td>C4;</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td><td></td>
<td>A1-B18-C5;</td><td>A1-B18-C6;</td><td>A1-B18-C7;</td><td>A1-B18-C8;</td><td>A1-B18-C9;</td><td>A1-B18-</td><td>C1O;</td>
<td>A1-B18-C11;</td><td>A1-B18-C12;</td><td>A1-B18-C13;</td><td>A1-B18-C14;</td><td>A1-B18-C15;</td><td>A1-B18-</td><td>C16;</td>
<td>A1-B18-C17;</td><td>A1-B18-C18;</td><td>A1-B18-C19;</td><td>A1-B18-C20;</td><td>A1-B18-C21;</td><td>A1-B18-</td><td>C22;</td>
<td>A1-B18-C23;</td><td>A1-B18-C24;</td><td>A1-B18-C25;</td><td>A1-B18-C26;</td><td>A1-B18-C27;</td><td>A1-B18-</td><td>C28;</td>
<td>A1-B18-C29;</td><td>A1-B18-C3O;</td><td>A1-B18-C31;</td><td>A1-B18-C32;</td><td>A1-B18-C33;</td><td>A1-B18-</td><td>C34;</td>
<td>A1-B18-C35;</td><td>A1-B18-C36;</td><td>A1-B18-C37;</td><td>A1-B18-C38;</td><td>A1-B18-C39;</td><td>A1-B18-</td><td>C4O;</td>
125
A1-B18-C41;
A2-B18-C1;
A2-B18-C7;
A2-B18-C13;
A2-B18-C19;
A2-B18-C25;
A2-B18-C31;
A2-B18-C37;
A2-B18-C43;
A3-B18-C3;
A3-B18-C9;
A3-B18-C15;
A3-B18-C21;
A3-B18-C27;
A3-B18-C33;
A3-B18-C39;
A3-B18-C45;
A4-B18-C5;
A4-B18-C11;
A4-B18-C17;
A4-B18-C23;
A4-B18-C29;
A4-B18-C35;
A4-B18-C41;
A5-B18-C1;
A5-B18-C7;
A5-B18-C13;
A5-B18-C19;
A5-B18-C25;
A5-B18-C31;
A5-B18-C37;
A5-B18-C43;
A6-B18-C3;
A6-B18-C9;
A6-B18-C15;
A6-B18-C21;
A6-B18-C27;
A6-B18-C33;
A6-B18-C39;
A6-B18-C45;
A7-B18-C5;
A7-B18-C11;
A7-B18-C17;
A7-B18-C23;
A7-B18-C29;
A7-B18-C35;
A7-B18-C41;
A8-B18-C1;
A8-B18-C7;
A8-B18-C13;
A8-318-C19;
A8-B18-C25;
A8-318-C31;
A8-B18-C37;
A8-B18-C43;
A9-B18-C3;
A9-318-C9;
A9-B18-C15;
A9-B18-C21;
A9-B18-C27;
A9-B18-C33;
A9-B18-C39;
A9-B18-C45;
A1-B18-C42;
A2-B18-C2;
A2-B18-C8;
A2-B18-C14;
A2-B18-C20;
A2-B18-C26;
A2-B18-C32;
A2-B18-C38;
A2-B18-C44; A3-318-C4;
A3-B18-C10;
A3-B18-C16;
A3-318-C22;
A3-B18-C28;
A3-B18-C34;
A3-B18-C40;
A3-318-C46;
A4-B18-C6;
A4-B18-C12;
A4-B18-C18;
A4-B18-C24;
A4-B18-C30;
A4-318-C36;
A4-318-C42;
A5-B18-C2;
A5-B18-C8;
A5-B18-C14;
A5-B18-C20;
A5-B18-C26;
A5-B18-C32;
A5-B18-C38;
A5-B18-C44;
A6-318-C4;
A6-318-C10;
A6-B18-C16;
A6-318-C22;
A6-B18-C28;
A6-318-C34;
A6-B18-C40;
A6-318-C46;
A7-518-C6;
A7-B18-C12;
A7-B18-C18;
A7-318-C24;
A7-B18-C30;
A7-B18-C36;
A7-B18-C42;
A8-B18-C2; .
A8-E18-C8;
A8-318-C14;
A8-318-C20;
A8-E18-C26;
A8-318-C32;
A8-B18-C38;
A8-B18-C44; A9-E18-C4;
A9-B18-C10;
A9-B18-C16;
A9-B18-C22;
A9-B18-C28;
A9-B18-C34;
A9-B18-C40;
A9-B18-C46;
A1-B18-C43;
A2-B18-C3;
A2-B18-C9;
A2-B18-C15;
A2-B18-C21;
A2-B18-C27;
A2-B18-C33;
A2-B18-C39;
A2-B18-C45;
A3-B18-C5;
A3-B18-C11;
A3-B18-C17;
A3-B18-C23;
A3-B18-C29;
A3-B18-C35;
A3-B18-C41;
A4-318-C1;
A4-B18-C7;
A4-B18-C13;
A4-B18-C19;
A4-B18-C25;
A4-B18-C31;
A4-B18-C37;
A4-B18-C43;
A5-318-C3;
A5-B18-C9;
A5-B18-C15;
A5-B18-C21;
A5-318-C27;
A5-B18-C33;
A5-318-C39;
A5-B18-C45;
A6-B18-C5;
A6-B18-C11;
A6-B18-C17;
A6-B18-C23;
A6-B18-C29;
A6-B18-C35;
A6-B18-C41;
A7-B18-C1;
A7-B18-C7;
A7-B18-C13;
A7-B18-C19;
A7-B18-C25;
A7-B18-C31;
A7-B18-C37;
A7-B18-C43;
A8-B18-C3;
A8-318-C9;
A8-B18-C15;
A8-B18-C21;
A8-B18-C27;
A8-B18-C33;
A8-B18-C39;
A8-B18-C45;
A9-B18-C5;
A9-B18-C11;
A9-B18-C17;
A9-B18-C23;
A9-B18-C29;
A9-B18-C35;
A9-B18-C41;
A10-B18-C1;
A1-B18-C44;
A2-B18-C4;
A2-B18-C10;
A2-B18-C16;
A2-B18-C22;
A2-B18-C28;
A2-B18-C34;
A2-B18-C40;
A2-B18-C46;
A3-B18-C6;
A3-B18-C12;
A3-B18-C18;
A3-B18-C24;
A3-B18-C30;
A3-B18-C36;
A3-B18-C42;
A4-B18-C2;
A4-B18-C8;
A4-B18-C14;
A4-B18-C20;
A4-B18-C26;
A4-B18-C32;
A4-B18-C38;
A4-B18-C44;
A5-B18-C4;
A5-B18-C10;
A5-B18-C16;
A5-B18-C22;
A5-B18-C28;
A5-B18-C34;
A5-B18-C40;
A5-B18-C46;
A6-B18-C6;
A6-B18-C12;
A6-B18-C18;
A6-B18-C24;
A6-B18-C30;
A6-318-C36;
A6-B18-C42;
A7-B18-C2;
A7-B18-C8;
A7-B18-C14;
A7-B18-C20;
A7-318-C26;
A7-B18-C32;
A7-B18-C38;
A7-B18-C44; A8-B18-C4;
A8-B18-C10;
A8-318-C16;
A8-B18-C22;
A8-B18-C28;
A8-B18-C34;
A8-B18-C40;
A8-B18-C46; A9-B18-C6;
A9-B18-C12;
A9-318-C18;
A9-B18-C24;
A9-B18-C30;
A9-B18-C36;
A9-B18-C42;
A10-B18-C2;
A1-B18-C45;
A2-B18-C5;
A2-B18-C11;
A2-B18-C17;
A2-B18-C23;
A2-B18-C29;
A2-B18-C35;
A2-B18-C41; A3-B18-C1;
A3-B18-C7;
A3-B18-C13;
A3-B18-C19;
A3-B18-C25;
A3-B18-C31;
A3-B18-C37;
A3-B18-C43;
A4-B18-C3;
A4-B18-C9;
A4-B18-C15;
A4-B18-C21;
A4-B18-C27;
A4-B18-C33;
A4-B18-C39;
A4-B18-C45;
A5-B18-C5;
A5-B18-C11;
A5-B18-C17;
A5-B18-C23;
A5-B18-C29;
A5-B18-C35;
A5-B18-C41; A6-B18-C1;
A6-B18-C7;
A6-B18-C13;
A6-B18-C19;
A6-B18-C25;
A6-B18-C31;
A6-B18-C37;
A6-B18-C43;
A7-B18-C3;
A7-B18-C9;
A7-B18-C15;
A7-B18-C21;
A7-B18-C27;
A7-B18-C33;
A7-B18-C39;
A7-B18-C45; A8-B18-C5;
A8-B18-C11;
A8-B18-C17;
A8-B18-C23;
A8-B18-C29;
A8-B18-C35;
A8-B18-C41;
A9-B18-C1;
A9-B18-C7;
A9-B18-C13;
A9-B18-C19;
A9-B18-C25;
A9-B18-C31;
A9-B18-C37;
A9-B18-C43;
A10-B18-C3;
A1-B18-C46;
A2-B18-C6;
A2-B18-C12;
A2-B18-C18;
A2-B18-C24;
A2-B18-C30;
A2-B18-C36;
A2-B18-C42;
A3-B18-C2;
A3-B1S-C8;
A3-B18-C14;
A3-B18-C20;
A3-B18-C26;
A3-B18-C32;
A3-B18-C38;
A3-B18-C44;
A4-B18-C4;
A4-B18-C10;
A4-B13-C16;
A4-B18-C22;
A4-B1E-C28;
A4-B18-C34;
A4-B18-C40;
A4-B18-C46;
A5-B18-C6;
A5-B18-C12;
A5-B18-C18;
A5-B18-C24;
A5-B18-C30;
A5-B18-C36;
A5-B18-C42;
A6-B18-C2;
A6-B18-C8;
A6-B18-C14;
A6-B18-C20;
A6-B18-C26;
A6-B18-C32;
A6-B18-C38;
A6-B13-C44;
A7-B18-C4;
A7-B13-C10;
A7-B18-C16;
A7-B18-C22;
A7-B18-C28;
A7-B18-C34;
A7-B18-C40;
A7-B18-C46;
A8-B18-C6;
A8-B18-C12;
A8-B18-C18;
A8-B18-C24;
A8-B18-C30;
A8-B18-C36;
A8-B18-C42;
A9-B18-C2;
A9-B18-C8;
A9-B1Č-C14;
A9-B18-C20;
A9-B18-C26;
A9-B18-C32;
A9-B18-C38;
A9-B18-C44;
A1O-B18-C4;
126
A10-B18-C5;
Α10-Β18Cll;
A10-B18C17;
A10-B18C23;
A10-B18C29;
A10-B18C35;
A10-B18C41;
A11-B18-C1;
A11-B18-C7;
A11-B18C13;
A11-B18C19;
A11-B18C25;
A11-B18C31;
A11-B18C37;
A11-B18C4 3;
A12-B18-C3;
A12-B18-C9;
A12-B18C15;
A12-B18C21;
A12-B18C27;
A12-B18C33;
A12-B18C39;
A12-B18C4 5;
A13-B18-C5;
A13-B18Cll;
A13-B18C17;
A13-B18C23;
A13-B18C29;
A13-B18C35;
A13-B18C41;
A14-B18-C1;
A14-B18-C7;
A14-B18C13;
A10-B18-C6;
A10-B18C12;
A10-B18C18;
A10-B18C24;
A10-B18C30;
A10-B18C36;
A10-B18C4 2;
A11-B18-C2;
A11-B18-C8;
Α11-Β18C14;
A11-B18C20;
A11-B18C26;
A11-B18C32;
A11-B18C38;
A11-B18C4 4;
A12-B18-C4;
A12-B18C10;
A12-B18C16;
A12-B18C22;
A12-B18C28;
A12-B18C34; '
A12-B18C4O;
A12-B18C4 6;
A13-B18-C6;
A13-B18C12;
A13-B18C18;
A13-B18C24;
A13-B18C o O ;
A13-B18C3 6;
A13-B18C4 2;
A14-B18-C2;
A14-B18-C8;
A14-B18C14;
A10-B18-C7;
A10-B18C13;
A10-B18C19;
A10-B18C25;
A10-B18C31;
A10-B18C37;
A10-B18C4 3;
A11-B18-C3;
A11-B18-C9;
A11-B18C15;
A11-B18C21;
A11-B18C27;
A11-B18C33;
A11-B18C39;
A11-B18C4 5;
A12-B18-C5;
A12-B18Cll;
A12-B18C17;
A12-B18C23;
A12-B18C29;
A12-B18C35;
A12-B18C41;
A13-B18-C1;
A13-B18-C7;
A13-B18C13;
A13-B18C19;
A13-B18C25;
A13-B18C31;
A13-B18C37;
A13-B18C4 3;
A14-B18-C3;
A14-B18-C9;
A14-B18C15;
A10-B18-C8;
A10-B18C14;
A10-B18C20;
A10-B18C2 6;
A10-B18C32;
A10-B18C38;
A10-B18C4 4;
A11-B18-C4;
A11-B18C1O;
A11-B18C16;
A11-B18C22;
A11-B18C28;
A11-B18C34;
A11-B18C4O;
A11-B18C4 6;
A12-B18-C6;
A12-B18C12;
A12-B18C18;
A12-B18C2 4;
A12-B18C30;
A12-B18C36;
A12-B18C4 2;
A13-B18-C2;
A13-B18-C8;
A13-B18C14 ;
A13-B18C20;
A13-B18C2 6;
A13-B18C32;
A13-B18C38;
A13-B18C4 4 ;
A14-B18-C4;
A14-B18C1O;
A14-B18C16;
A10-B18-C9;
A10-B18C15;
A10-B18C21; A10-B18C27;
A10-B18C33;
A10-B18C39;
A10-B18C45;
A11-B18-C5;
A11-B18Cll;
A11-B18C17;
A11-B18C23;
A11-B18C29;
A11-B18C35;
A11-B18C41 ;
A12-B18-C1;
A12-B18-C7;
A12-B18C13;
A12-B18C19;
A12-B18C2 5;
A12-B18C31;
A12-B18C37;
A12-B18C4 3;
A13-B18-C3;
A13-B18-C9;
A13-B18C15;
A13-B18C21;
A13-B18C27;
A13-B18C33;
A13-B18C39;
A13-B18C4 5;
A14-B18-C5;
A14-B18Cll;
A14-B18C17;
A10-B18C.1O;
A10-B18C16;
A10-B18C22;
A10-B18C28;
A10-B18C34 ;
A10-B18C4 0;
A10-B18C4 6;
All-E18-C6;
A11-E18C12;
A11-B18C18;
A11-B18C2 4 ;
A11-B18C30;
A11-E18C36;
A11-B18C4 2;
A12-B18-C2;
A12-B18-C8;
A12-B18C14 ;
A12-B13C20;
A12-B13C26;
A12-B13C32;
A12-B18C38;
A12-B18C4 4 ;
A13-B1B-C4;
A13-B13C1O;
A13-B13C16;
A13-B13C22;
A13-B15C28;
A13-B18C34 ;
A13-B13C4O;
A13-B1SC4 6;
A14-B18-C6;
A14-B18C12;
A14-B13C18;
127
<td>Α14-Β18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td>
<td>Α14-Β18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α14-Β18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C3 6;</td>
<td>Α14-Β18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td><td>A14-B18-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α14-Β18-</td><td>A14-BL8-</td><td>A14-B18-</td><td>A14-B18-</td><td>A15-B18-C1;</td><td>A15-B18-C2;</td>
<td>C4 3; A15-B18-C3;</td><td>C4 4; A15-B18-C4;</td><td>C4 5; A15-B18-C5;</td><td>C4 6; A15-B18-C6;</td><td>A15-B18-C7;</td><td>A15-B18-C8;</td>
<td>A15-B18-C9;</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>Α15-Β18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C2 0;</td>
<td>Α15-Β18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>Α15-Β18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α15-Β18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α15-Β18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td><td>A15-B18-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α15-Β18-</td><td>A15-B18-</td><td>A16-B18-C1;</td><td>A16-B18-C2;</td><td>A16-B18-C3;</td><td>A16-B18-C4;</td>
<td>C4 5; A16-B18-C5;</td><td>C4 6; A16-B18-C6;</td><td>A16-B18-C7;</td><td>A16-B18-C8;</td><td>A16-B18-C9;</td><td>A16-B18-</td>
<td>Α16-Β18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18- .</td><td>A16-B18-</td><td>C1O; A16-B18-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td>
<td>C29;</td><td>C3O;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td><td>A16-B18-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A17-B18-C1;</td><td>A17-B18-C2;</td><td>A17-B18-C3;</td><td>A17-B18-C4;</td><td>A17-B18-C5;</td><td>A17-B18-C6;</td>
<td>A17-B18-C7;</td><td>A17-B18-C8;</td><td>A17-B18-C9;</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td>
<td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>C10; A17-B18-</td><td>Cll; A17-B18-</td><td>C12; A17-B18-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td>
<td>C19;</td><td>C2O;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td>
<td>C2 5;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A17-B18-</td><td>A18-B18-C1;</td><td>A18-B18-C2;</td>
<td>C4 3; A18-B18-C3;</td><td>C4 4 ; A18-318-C4;</td><td>C4 5; A18-B18-C5;</td><td>C4 6; A18-B18-C6;</td><td>A18-B18-C7;</td><td>A18-B18-C8;</td>
<td>A13-B18-C9;</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td>
<td>C15;</td><td>C16;</td><td>C17 ;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
128
<td>Α18-Β18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α18-Β18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td><td>A18-B18-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α18-Β18-</td><td>A18-B18-</td><td>A19-B18-C1;</td><td>A19-B18-C2;</td><td>A19-B18-C3;</td><td>A19-B18-C4;</td>
<td>C4 5; A19-B18-C5;</td><td>C4 6; A19-B18-C6;</td><td>A19-B18-C7;</td><td>A19-B18-C8;</td><td>A19-B18-C9;</td><td>A19-E18-</td>
<td>Α19-Β18-</td><td>A19-BÍ8-</td><td>Al 9-318-,</td><td>A19-B18-</td><td>A19-B18-</td><td>C1O; A19-B18-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-E18-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C2O;</td><td>C21;</td><td>C22;</td>
<td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td>
<td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27 ;</td><td>C28;</td>
<td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-E18-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td><td>A19-B18-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A20-B18-C1;</td><td>A20-B18-C2;</td><td>A20-B18-C3;</td><td>A20-B18-C4;</td><td>A2O-B18-C5;</td><td>A20-B18-C6;</td>
<td>A20-B18-C7;</td><td>A20-B18-C8;</td><td>A20-B18-C9;</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td>
<td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>C10; A20-B18-</td><td>Cll; A20-B18-</td><td>C12; A2O-B18-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A2O-B18-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24;</td>
<td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A2O-E13-</td>
<td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α20-Β1Θ-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A2O-B18-</td><td>A20-B18-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td>
<td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A20-B18-</td><td>A21-B18-C1;</td><td>A21-B13-C2;</td>
<td>C4 3; A21-B18-C3;</td><td>C4 4; A21-B18-C4;</td><td>C4 5; A21-B18-C5;</td><td>C4 6; A21-B18-C6;</td><td>A21-B18-C7;</td><td>A21-B13-C8;</td>
<td>A21-B18-C9;</td><td>A21-318-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B13-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B13-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B13-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B13-</td>
<td>C33;</td><td>C34 ;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>A21-B18-</td><td>A21-B18-</td><td>A2Í-B18-</td><td>A21-B18-</td><td>A21-B18-</td><td>A21-B13-</td>
<td>C39;</td><td>C4O; </td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A21-B18-</td><td>A21-B18-</td><td>A22-B18-C1;</td><td>A22-B18-C2;</td><td>A22-B18-C3;</td><td>A22-B18-C4;</td>
<td>C45; A22-B18-C5;</td><td>' C4 6; A22-B18-C6;</td><td>A22-B18-C7;</td><td>A22-B18-C8;</td><td>A22-B18-C9;</td><td>A22-B18-</td>
<td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>C1O; A22-B1S-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B13-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td><td>A22-B18-</td>
129
C41;
A23-B18-C1;
A23-B18-C7;
Α23-Β18C13;
Α23-Β18C19;
Α23-Β18C2 5;
Α23-Β18C31;
Α23-Β18C37 ;
Α23-Β18C4 3;
A24-B18-C3;
A24-B18-C9;
Α24-Β18C15;
Α24-Β18C21;
Α24-Β18C27;
Α24-Β18C33;
Α24-Β18C39;
Α24-Β18C4 5;
A25-B18-C5;
Α25-Β18Cll;
A25-B18C17;
A25-B18C2 3;
A25-B18C29;
A25-B18C35;
A25-B18C41;
A26-B18-C1;
A26-B18-C7;
A26-B18C13;
A26-B18C19;
A26-B18C2 5;
A26-B18C31;
A26-B18C37;
A26-B18C4 3;
A27-B18-C3;
A27-B18-C9;
C42;
A23-B18-C2;
A23-B18-C8;
A23-B18C14 ;
A23-B18C20;
A23-B18C2 6;
A23-B18C32;
A23-B18C38;
A23-B18C4 4;
A24-B18-C4;
A24-B18C10;
A24-B18C16;
A24-B18C22;
A24-B18C28;
A24-B18C34;
A24-B18C4 0;
A24-B18C4 6;
A25-B18-C6;
Š25-B18C12;
A25-B18C18;
A25-B18C24;
A25-B18C30;
A25-B18C3 6;
A25-B18C4 2;
A26-B18-C2;
A26-B18-C8;
A26-B18C14;
A26-B18C20;
A26-B18C2 6;
A26-B18C32;
A26-B18C38;
A26-B18C4 4;
A27-B18-C4;
A27-B18CiO;
C43;
A23-B18-C3;
A23-B18-C9;
A23-B18C15;
A23-B18C21;
A23-B18C27;
A23-B18C33;
A23-B18C39;
A23-B18C4 5; A24-B18-C5;
A24-B18Cll;
A24-B18C17;
A24-B18C2 3;
A24-B18C29;
A24-B18C35;
A24-B18C41;
A25-B18-C1;
A25-B18-C7;
A25-B18C13;
A25-B18C19;
A25-B18C25;
A25-B18C31;
A25-B18C37;
A25-B18C4 3;
A26-B18-C3;
A26-B18-C9;
A26-B18C15;
A26-B18C21;
A26-B18C27;
A26-B18C33;
A26-B18C39;
A26-B18C4 5;
A27-B18-C5; A27-B18C1I;
C4 4;
A23-B18-C4;
A23-B18C1O;
A23-B18C16;
A23-B18C22;
A23-B18C2 8;
A23-B18C34 ;
A23-B18C4O;
A23-B18C4 6;
A24-B18-C6;
A24-B18C12;
A24-B18C18;
A24-B18C24;
A24-B18C30;
A24-B18C36;
A24-B18C4 2;
A25-B18-C2;
A25-B18-C8;
A25-B18C14;
A25-B18C20;
A25-B18C26;
A25-B18C32;
A25-B18C38;
A25-B18C4 4;
A26-B18-C4;
A26-B18C1O;
A26-B18C16;
A26-B18C22;
A26-B18C28;
A26-B18C34;
A26-B18C4O;
A26-B18C4 6;
A27-B18-C6;
A27-B18C12;
C4 5; A23-B18-C5; A23-B18Cll;
A23-B18C17;
A23-B18C23;
A23-B18C2 9;
A23-B18C35;
A23-B18C41;
A24-B18-C1;
A24-B18-C7;
A24-B18C13;
Α24-Ξ18C19;
A24-E18C25;
A24-B18C31;
A24-B18C37;
A24-B18C4 3;
A25-318-C3;
A25-B18-C9;
A25-B18C15;
Α25-Ξ18C21;
A25-E18C27;
Α25-Ξ18C33;
A25-B18C39;
A25-B18C4 5; A26-B18-C5; A26-E18Cll;
A26-B18C17;
A26-B18C23;
A26-318C2 9;
A26-318C35;
A26-B18C41;
A27-B18-C1;
A27-B18-C7;
A27-B18C13;
C4 6;
A23-B18-C6;
A23-B18C12;
A23-B18C18;
A23-B18C2 4 ;
A23-B18C30;
A23-B18C36;
A23-B18C4 2;
A24-B18-C2;
A24-B18-C8;
A24-3L8C14;
A24-E18C2 0;
A24-B18C2 6;
A24-B18C32;
A24-B18C38;
A24-B18- ·
C4 4;
A25-B18-C4;
A25-B18C1O;
A25-B13C16;
A25-B13C22;
A25-B18C2 8;
A25-E13C34;
A25-E13C4O;
A25-B18C4 6;
A26-E18-C6;
A26-B18C12;
A26-ELSC18;
Ά26-Β18C2 4 ;
A26-EL8C30;
A26-518C3 6;
A26-B18C4 2;
A27-B18-C2;
A27-B18-C8;
A27-B18C14;
130
<td>Α27-Β18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α27-Β18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td><td>C2 5;</td><td>C2 6;</td>
<td>Α27-Β18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α27-Β18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α27-Β18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td><td>A27-B18-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α27-Β18-</td><td>A27-B18-</td><td>A28-B18-C1;</td><td>A28-B18-C2;</td><td>A28-B18-C3;</td><td>A28-B18-C4;</td>
<td>C4 5; A28-B18-C5;</td><td>C4 6; A28-B18-C6;</td><td>A28-B18-C7;</td><td>A28-B18-C8;</td><td>A28-B18-C9;</td><td>A28-B18-</td>
<td>Α28-Β18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>C10; A28-B18-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td> C20;</td><td>C21;</td><td>C22;</td>
<td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td><td>A28-B18-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A1-B19-C1;</td><td>A1-B19-C2;</td><td>A1-B19-C3;</td><td>A1-B19-C4;</td><td>A1-B19-C5;</td><td>A1-B19-C6;</td>
<td>A1-B19-C7;</td><td>A1-B19-C8;</td><td>A1-B19-C9;</td><td>A1-B19-C10;</td><td>A1-B19-C11;</td><td>A1-B19-C12;</td>
<td>A1-B19-C13;</td><td>A1-B19-C14;</td><td>A1-B19-C15;</td><td>A1-B19-C16;</td><td>A1-B19-C17;</td><td>A1-B19-C18;</td>
<td>A1-B19-C19;</td><td>A1-B19-C20;</td><td>A1-B19-C21;</td><td>A1-B19-C22;</td><td>A1-B19-C23;</td><td>A1-B19-C24;</td>
<td>A1-B19-C25;</td><td>A1-B19-C26;</td><td>A1-B19-C27;</td><td>A1-B19-C28;</td><td>A1-B19-C29;</td><td>A1-B19-C30;</td>
<td>A1-B19-C31;</td><td>A1-B19-C32;</td><td>A1-B19-C33;</td><td>A1-B19-C34;</td><td>A1-B19-C35;</td><td>A1-B19-C36;</td>
<td>A1-B19-C37;</td><td>A1-B19-C38;</td><td>A1-B19-C39;</td><td>A1-B19-C40;</td><td>A1-B19-C41;</td><td>A1-B19-C42;</td>
<td>A1-B19-C43;</td><td>A1-B19-C44;</td><td>A1-B19-C45;</td><td>A1-B19-C46;</td><td>A2-B19-C1;</td><td>A2-B19-C2;</td>
<td>A2-B19-C3;</td><td>A2-B19-C4;</td><td>A2-B19-C5;</td><td>A2-B19-C6;</td><td>A2-B19-C7;</td><td>A2-B19-C8;</td>
<td>A2-B19-C9;</td><td>A2-B19-C10;</td><td>A2-B19-C11;</td><td>A2-B19-C12;</td><td>A2-B19-C13;</td><td>A2-B19-C14;</td>
<td>A2-B19-C15;</td><td>A2-B19-C16;</td><td>A2-B19-C17;</td><td>A2-B19-C18;</td><td>A2-B19-C19;</td><td>A2-B19-C20;</td>
<td>A2-B19-C21;</td><td>A2-B19-C22;</td><td>A2-B19-C23;</td><td>A2-B19-C24;</td><td>A2-B19-C25;</td><td>A2-B19-C26;</td>
<td>A2-B19-C27;</td><td>A2-B19-C28;</td><td>A2-B19-C29;</td><td>A2-B19-C30;</td><td>A2-B19-C31;</td><td>A2-B19-C32;</td>
<td>A2-B19-C33;</td><td>A2-B19-C34;</td><td>A2-B19-C35;</td><td>A2-B19-C36;</td><td>A2-B19-C37;</td><td>A2-B19-C38;</td>
<td>A2-B19-C39;</td><td>A2-B19-C4O;</td><td>A2-B19-C41;</td><td>A2-B19-C42;</td><td>A2-B19-C43;</td><td>A2-B19-C44;</td>
<td>A2-B19-C45;</td><td>A2-B19-C46;</td><td>A3-B19-C1;</td><td>A3-B19-C2;</td><td>A3-B19-C3;</td><td>A3-B19-C4;</td>
<td>A3-B19-C5;</td><td>A3-B19-C6;</td><td>A3-B19-C7;</td><td>A3-B19-C8;</td><td>A3-B19-C9;</td><td>A3-B19-C10;</td>
<td>A3-B19-CU;</td><td>A3-B19-C12;</td><td>A3-B19-C13;</td><td>A3-B19-C14;</td><td>A3-B19-C15;</td><td>A3-B19-C16;</td>
<td>A3-B19-C17;</td><td>A3-B19-C18;</td><td>A3-B19-C19;</td><td>A3-B19-C20;</td><td>A3-B19-C21;</td><td>A3-B19-C22;</td>
<td>A3-B19-C23;</td><td>A3-B19-C24;</td><td>A3-B19-C25;</td><td>A3-B19-C26;</td><td>A3-B19-C27;</td><td>A3-B19-C28;</td>
<td>A3-B19-C29;</td><td>A3-B19-C30;</td><td>A3-B19-C31;</td><td>A3-B19-C32;</td><td>A3-B19-C33;</td><td>A3-B19-C34;</td>
<td>A3-B19-C35;</td><td>A3-B19-C36;</td><td>A3-B19-C37;</td><td>A3-B19-C38;</td><td>A3-B19-C39;</td><td>A3-B19-C40;</td>
<td>A3-B19-C41;</td><td>A3-B19-C42;</td><td>A3-B19-C43;</td><td>A3-B19-C44;</td><td>A3-B19-C45;</td><td>A3-B19-C46;</td>
<td>A4-B19-C1;</td><td>A4-B19-C2;</td><td>A4-B19-C3;</td><td>A4-B19-C4;</td><td>A4-B19-C5;</td><td>A4-B19-C6;</td>
<td>A4-B19-C7;</td><td>A4-B19-C8;</td><td>A4-B19-C9;</td><td>A4-B19-C10;</td><td>A4-B19-C11;</td><td>A4-B19-C12;</td>
<td>A4-B19-C13;</td><td>A4-B19-C14;</td><td>A4-B19-C15;</td><td>A4-B19-C16;</td><td>A4-B19-C17;</td><td>A4-B19-C18;</td>
<td>A4-B19-C19;</td><td>A4-B19-C20;</td><td>A4-B19-C21;</td><td>A4-B19-C22;</td><td>A4-B19-C23;</td><td>A4-B19-C24;</td>
<td>A4-B19-C25;</td><td>A4-B19-C26;</td><td>A4-B19-C27;</td><td>A4-B19-C28;</td><td>A4-B19-C29;</td><td>A4-B19-C30;</td>
<td>A4-B19-C31;</td><td>A4-B19-C32;</td><td>A4-B19-C33;</td><td>A4-B19-C34;</td><td>A4-B19-C35;</td><td>A4-B19-C36;</td>
<td>A4-B19-C37;</td><td>A4-B19-C38;</td><td>A4-B19-C39;</td><td>A4-B19-C40;</td><td>A4-B19-C41;</td><td>A4-B19-C42;</td>
<td>A4-B19-C43;</td><td>A4-B19-C44;</td><td>A4-B19-C45;</td><td>A4-B19-C46;</td><td>A5-B19-C1;</td><td>A5-B19-C2;</td>
<td>A5-B19-C3;</td><td>A5-B19-C4;</td><td>A5-B19-C5;</td><td>A5-B19-C6;</td><td>A5-B19-C7;</td><td>A5-B19-C8;</td>
<td>A5-B19-C9;</td><td>A5-B19-C10;</td><td>A5-B19-C11;</td><td>A5-B19-C12;</td><td>A5-B19-C13;</td><td>A5-B19-C14;</td>
<td>A5-B19-C15;</td><td>A5-B19-C16;</td><td>A5-B19-C17;</td><td>A5-B19-C18;</td><td>A5-B19-C19;</td><td>A5-B19-C20;</td>
<td>A5-B19-C21;</td><td>A5-B19-C22;</td><td>A5-B19-C23;</td><td>A5-B19-C24;</td><td>A5-B19-C25;</td><td>A5-B19-C26;</td>
<td>A5-B19-C27;</td><td>A5-B19-C28;</td><td>A5-B19-C29;</td><td>A5-B19-C30;</td><td>A5-B19-C31;</td><td>A5-B19-C32;</td>
<td>A5-B19-C33;</td><td>A5-B19-C34;</td><td>A5-B19-C35;</td><td>A5-B19-C36;</td><td>A5-B19-C37;</td><td>A5-B19-C38;</td>
131
<td>A5-B19-C39;</td><td>A5-B19-C40;</td><td>A5-B19-C41;</td><td>A5-B19-C42;</td><td>A5-B19-C43;</td><td>A5-B19-C44;</td>
<td>A5-B19-C45;</td><td>A5-B19-C46;</td><td>A6-B19-C1;</td><td>A6-B19-C2;</td><td>A6-B19-C3;</td><td>A6-B19-C4;</td>
<td>A6-B19-C5;</td><td>A6-B19-C6;</td><td>A6-B19-C7;</td><td>A6-B19-C8;</td><td>A6-B19-C9;</td><td>A6-B19-C10;</td>
<td>A6-B19-C11;</td><td>A6-B19-C12;</td><td>A6-B19-C13;</td><td>A6-B19-C14;</td><td>A6-B19-C15;</td><td>A6-B19-C16;</td>
<td>A6-B19-C17;</td><td>A6-B19-C18;</td><td>A6-B19-C19;</td><td>A6-B19-C20;</td><td>A6-B19-C21;</td><td>A6-B19-C22;</td>
<td>A6-B19-C23;</td><td>A6-B19-C24;</td><td>A6-B19-C25;</td><td>A6-B19-C26;</td><td>A6-B19-C27;</td><td>A6-B19-C28;</td>
<td>A6-B19-C29;</td><td>A6-B19-C30;</td><td>A6-B19-C31;</td><td>A6-B19-C32;</td><td>A6-B19-C33;</td><td>A6-B19-C34;</td>
<td>A6-B19-C35;</td><td>A6-B19-C36;</td><td>A6-B19-C37;</td><td>A6-B19-C38;</td><td>A6-B19-C39;</td><td>A6-B19-C40;</td>
<td>A6-B19-C41;</td><td>A6-B19-C42;</td><td>A6-B19-C43;</td><td>A6-B19-C44;</td><td>A6-B19-C45;</td><td>A6-B19-C46;</td>
<td>A7-B19-C1;</td><td>A7-B19-C2;</td><td>A7-B19-C3;</td><td>A7-B19-C4;</td><td>A7-B19-C5;</td><td>A7-B19-C6;</td>
<td>A7-B19-C7;</td><td>A7-B19-C8;</td><td>A7-B19-C9;</td><td>A7-B19-C10;</td><td>A7-B19-C11;</td><td>A7-B19-C12;</td>
<td>A7-B19-C13;</td><td>A7-B19-C14;</td><td>A7-B19-C15;</td><td>A7-B19-C16;</td><td>A7-B19-C17;</td><td>A7-B19-C18;</td>
<td>A7-B19-C19;</td><td>A7-B19-C20;</td><td>A7-B19-C21;</td><td>A7-B19-C22;</td><td>A7-B19-C23;</td><td>A7-B19-C24;</td>
<td>A7-B19-C25;</td><td>A7-B19-C26;</td><td>A7-B19-C27;</td><td>A7-B19-C28;</td><td>A7-B19-C29;</td><td>A7-B19-C30;</td>
<td>A7-B19-C31;</td><td>A7-B19-C32;</td><td>A7-B19-C33;</td><td>A7-B19-C34;</td><td>A7-B19-C35;</td><td>A7-B19-C36;</td>
<td>A7-B19-C37;</td><td>A7-B19-C38;</td><td>A7-B19-C39;</td><td>A7-B19-C40;</td><td>A7-B19-C41;</td><td>A7-B19-C42;</td>
<td>A7-B19-C43;</td><td>A7-B19-C44;</td><td>A7-B19-C45;</td><td>A7-B19-C46;</td><td>A8-B19-C1;</td><td>A8-B19-C2;</td>
<td>A8-B19-C3;</td><td>A8-B19-C4;</td><td>A8-B19-C5; ·</td><td>A8-B19-C6;</td><td>A8-B19-C7;</td><td>A8-B19-C8;</td>
<td>A8-B19-C9;</td><td>A8-B19-C10;</td><td>A8-B19-C11;</td><td>A8-B19-C12;</td><td>A8-B19-C13;</td><td>A8-B19-C14;</td>
<td>A8-B19-C15;</td><td>A8-B19-C16;</td><td>A8-B19-C17;</td><td>A8-B19-C18;</td><td>A8-B19-C19;</td><td>A8-B19-C20;</td>
<td>A8-B19-C21;</td><td>A8-B19-C22;</td><td>A8-B19-C23;</td><td>A8-B19-C24;</td><td>A8-B19-C25;</td><td>A8-B19-C26;</td>
<td>A8-B19-C27;</td><td>A8-B19-C28;</td><td>A8-B19-C29;</td><td>A8-B19-C30;</td><td>A8-B19-C31;</td><td>A8-B19-C32;</td>
<td>A8-B19-C33;</td><td>A8-B19-C34;</td><td>A8-B19-C35;</td><td>A8-B19-C36;</td><td>A8-B19-C37;</td><td>A8-B19-C38;</td>
<td>A8-B19-C39;</td><td>A8-B19-C40;</td><td>A8-B19-C41;</td><td>A8-B19-C42;</td><td>A8-B19-C43;</td><td>A8-B19-C44;</td>
<td>A8-B19-C45;</td><td>A8-B19-C46;</td><td>A9-B19-C1;</td><td>A9-B19-C2;</td><td>A9-B19-C3;</td><td>A9-B19-C4;</td>
<td>A9-B19-C5;</td><td>A9-B19-C6;</td><td>A9-B19-C7;</td><td>A9-B19-C8;</td><td>A9-B19-C9;</td><td>A9-B19-C10;</td>
<td>A9-B19-C11;</td><td>A9-B19-C12;</td><td>A9-B19-C13;</td><td>A9-B19-C14;</td><td>A9-B19-C15;</td><td>A9-B19-C16;</td>
<td>A9-B19-C17;</td><td>A9-B19-C18;</td><td>A9-B19-C19;</td><td>A9-B19-C20;</td><td>A9-B19-C21;</td><td>A9-B19-C22;</td>
<td>A9-B19-C23;</td><td>A9-B19-C24;</td><td>A9-B19-C25;</td><td>A9-B19-C26;</td><td>A9-B19-C27;</td><td>A9-B19-C28;</td>
<td>A9-B19-C29;</td><td>A9-B19-C30;</td><td>A9-B19-C31;</td><td>A9-B19-C32;</td><td>A9-B19-C33;</td><td>A9-B19-C34;</td>
<td>A9-B19-C35;</td><td>A9-B19-C36;</td><td>A9-B19-C37;</td><td>A9-B19-C38;</td><td>A9-B19-C39;</td><td>A9-B19-C40;</td>
<td>A9-B19-C41;</td><td>A9-B19-C42;</td><td>A9-B19-C43;</td><td>A9-B19-C44;</td><td>A9-B19-C45;</td><td>A9-B19-C46;</td>
<td>A10-B19-C1;</td><td>A10-B19-C2;</td><td>A10-B19-C3;</td><td>A10-B19-C4;</td><td>A10-B19-C5;</td><td>A1O-B19-C6;</td>
<td>A10-B19-C7;</td><td>A10-B19-C8;</td><td>A10-B19-C9;</td><td>A10-B19-</td><td>A1O-B19-</td><td>A10-B19-</td>
<td></td><td></td><td></td><td>C1O;</td><td>Cll;</td><td>C12;</td>
<td>Α10-Β19-</td><td>Α10-Β19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A1O-B19-</td>
<td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α10-Β19-</td><td>Α10-Β19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>Č22;</td><td>C23;</td><td>C24;</td>
<td>Α10-Β19-</td><td>Α10-Β19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α10-Β19-</td><td>Α10-Β19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α10-Β19- '</td><td>Α10-Β19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A10-B19-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α10-Β19-</td><td>Α10-Β19-</td><td>A10-B19-</td><td>A10-B19-</td><td>A11-B19-C1;</td><td>A11-B19-C2;</td>
<td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td><td></td><td></td>
<td>A11-B19-C3;</td><td>A11-B19-C4;</td><td>A11-B19-C5;</td><td>A11-B19-C6;</td><td>A11-B19-C7;</td><td>A11-B19-C8;</td>
<td>A11-B19-C9;</td><td>Α11-Β19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>Α11-Β19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>Α11-Β19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>Α11-Β19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>Α11-Β19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>Α11-Β19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td><td>A11-B19-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α11-Β19-</td><td>A11-B19-</td><td>A12-B19-C1;</td><td>A12-B19-C2;</td><td>A12-B19-C3;</td><td>A12-B19-C4;</td>
<td>C4 5;</td><td>C4 6;</td><td></td><td></td><td></td><td></td>
<td>A12-B19-C5;</td><td>A12-B19-C6;</td><td>A12-B19-C7;</td><td>A12-B19-C8;</td><td>A12-B19-C9;</td><td>A12-B19-</td>
132
C10;
<td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-319-</td>
<td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-319-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>A12-B19-</td><td>Α12-Ξ19-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A13-B19-C1;</td><td>A13-B19-C2;</td><td>A13-B19-C3;</td><td>A13-B19-C4;</td><td>A13-B19-C5;</td><td>A13-319-C6;</td>
<td>A13-B19-C7;</td><td>A13-B19-C8;</td><td>A13-B19-C9;</td><td>A13-B19-</td><td>A13-B19-</td><td>Α13-Ξ19-</td>
<td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>C1O; A13-B19-</td><td>Cll; A13-B19-</td><td>C12; A13-B19-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24 ;</td>
<td>A13-B19-</td><td>A13-B19-</td><td>Ä13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td>
<td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-319-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C3 6;</td>
<td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A13-B19-</td><td>A13-B19-</td><td>A13-B19-·</td><td>A13-B19-</td><td>A14-B19-C1;</td><td>A14-319-C2;</td>
<td>C4 3; A14-319-C3;</td><td>C4 4 ; A14-B19-C4;</td><td>C4 5; A14-B19-C5;</td><td>C4 6; A14-B19-C6;</td><td>A14-B19-C7;</td><td>A14-319-C8;</td>
<td>A14-B19-C9;</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>Α14-Ξ19-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>Α14-Ξ19-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-Ξ19-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>Α14-Ξ19-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>Α14-Ξ19-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td><td>A14-B19-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>A14-B19-</td><td>A14-B19-</td><td>A15-B19-C1;</td><td>A15-B19-C2;</td><td>A15-B19-C3;</td><td>A15-B19-C4;</td>
<td>C4 5; A15-B19-C5;</td><td>C4 6; A15-B19-C6;</td><td>A15-B19-C7;</td><td>A15-B19-C8;</td><td>A15-B19-C9;</td><td>A15-319- '</td>
<td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>C1O; Α15-Ξ19-</td>
<td>Cll;</td><td>CI2;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19- ·.</td><td>A15-B19-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-319-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>Α15-Ξ19-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td><td>A15-B19-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A16-B19-C1;</td><td>A16-B19-C2;</td><td>A16-B19-C3;</td><td>A16-B19-C4;</td><td>A16-B19-C5;</td><td>A16-319-C6;</td>
<td>A16-B19-C7;</td><td>A16-B19-C8;</td><td>A16-B19-C9;</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-319-</td>
<td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>C1O; A16-B19-</td><td>Cll; A16-B19-</td><td>C12; Ä16-B19-</td>
<td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-319-</td>
133
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td>
<td>Α16-Β19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>Α16-Β19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>Α16-Β19-</td><td>A16-B19-</td><td>A16-319-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td>
<td>C j / z</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A16-B19-</td><td>A17-B19-C1;</td><td>A17-B19-C2;</td>
<td>C4 3; A17-B19-C3;</td><td>C4 4; A17-B19-C4;</td><td>C4 5; A17-B19-C5;</td><td>C4 6; A17-B19-C6;</td><td>A17-B19-C7;</td><td>A17-B19-C8;</td>
<td>A17-B19-C9;</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C2O;</td>
<td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td>
<td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td><td>A17-B19-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A17-B19-</td><td>A17-B19-</td><td>A18-B19-C1;</td><td>A18-B19-C2;</td><td>A18-B19-C3;</td><td>A18-B19-C4;</td>
<td>C4 5; A18-B19-C5;</td><td>C4 6; A18-B19-C6;</td><td>A18-B19-C7;</td><td>A18-B19-C8;</td><td>A18-B19-C9;</td><td>A18-B19-</td>
<td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>C1O; A18-B19-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td>
<td>C23;</td><td>C24 ;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28 ;</td>
<td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-E19-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td><td>A18-B19-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A19-B19-C1;</td><td>A19-B19-C2;</td><td>A19-B19-C3;</td><td>A19-B19-C4;</td><td>A19-B19-C5;</td><td>A19-B19-C6;</td>
<td>A19-B19-C7;</td><td>A19-B19-C8;</td><td>A19-B19-C9;</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td>
<td>A19-B19-</td><td>A19-B19-</td><td>Α19-Ξ19-</td><td>C1O; A19-B19-</td><td>Cll; A19-B19-</td><td>C12; A19-B19-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A19-B19-</td><td>A19-B19-</td><td>Α19-Ξ19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A19-B19-</td><td>A19-B19-</td><td>Α19-Ξ19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A19-B19-</td><td>A20-B19-C1;</td><td>A20-B19-C2;</td>
<td>C4 3; A20-B19-C3;</td><td>C4 4; A20-B19-C4;</td><td>C4 5; A20-319-C5;</td><td>C4 6; A20-B19-C6;</td><td>A20-B19-C7;</td><td>A20-B19-C8;</td>
<td>A20-B19-C9;</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td>
<td>A20-B19-</td><td>A20-B19-</td><td>A20-319-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A20-B19-</td><td>A20-B19-</td><td>A20-319-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td>
134
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>Α20-Β19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td><td>A20-B19-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>Α20-Β19-</td><td>A20-B19-</td><td>A21-B19-C1;</td><td>A21-B19-C2;</td><td>A21-B19-C3;</td><td>A21-B19-C4;</td>
<td>C4 5; A21-B19-C5;</td><td>C4 6; A21-B19-C6;</td><td>A21-B19-C7;</td><td>A21-B19-C8;</td><td>A21-B19-C9;</td><td>A21-B19-</td>
<td>Α21-Β19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>C1O; A21-319-</td>
<td>Cll;</td><td>C12;</td><td>. C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td>
<td>C17;</td><td>C18;</td><td>•C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td>
<td>C2 3;</td><td>C2 4 ;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A21-B19-</td><td>A21-B19-</td><td>A21-319-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-319-</td>
<td>C29;</td><td>C30;</td><td>C3l·;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A21-B19-</td><td>A21-B19-</td><td>A21-319-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td><td>A21-B19-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A22-B19-C1;</td><td>A22-B19-C2;</td><td>A22-B19-C3;</td><td>A22-B19-C4;</td><td>A22-B19-C5;</td><td>A22-319-C6;</td>
<td>A22-B19-C7;</td><td>A22-B19-C3;</td><td>A22-B19-C9;</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td>
<td>A22-B19-</td><td>A22-B19-</td><td>A22-319-</td><td>C1O; A22-B19-</td><td>Cll; A22-B19-</td><td>C12; A22-B19-</td>
<td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A22-B19-</td><td>A22-B19-</td><td>A22-319-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-E19-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td>
<td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-B19-</td><td>A22-319-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A22-B19-</td><td>A22-B19-</td><td>Α22-Ξ19-</td><td>A22-B19-</td><td>A23-B19-C1;</td><td>A23-B19-C2;</td>
<td>C4 3; A23-B19-C3;</td><td>C4 4; A23-B19-C4;</td><td>C4 5; A23-319-C5;</td><td>C4 6; A23-B19-C6;</td><td>A23-B19-C7;</td><td>A23-319-C8;</td>
<td>A23-B19-C9;</td><td>A23-B19-</td><td>A23-319-</td><td>A23-B19-</td><td>A23-B19-</td><td>A23-B19-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A23-B19-</td><td>A23-B19-</td><td>A23-319-</td><td>A23-B19-</td><td>A23-B19-</td><td>A23-B19-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A23-B19-</td><td>A23-B19-</td><td>Α2Ξ-319-</td><td>A23-B19-</td><td>A23-B19-</td><td>A23-319-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>A23-B19-</td><td>A23-B19-</td><td>A23-319-</td><td>A23-B19-</td><td>A23-B19-</td><td>A23-B19-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A23-B19-</td><td>A23-B19-</td><td>A23-319-</td><td>A23-B19-</td><td>A23-B19-</td><td>Α23-Ξ19-</td>
<td>C33;</td><td>C34;</td><td>C33;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A23-B19-</td><td>A23-B19-</td><td>Α2Ξ-Β19-</td><td>A23-B19-</td><td>A23-B19-</td><td>A23-B19-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>A23-B19-</td><td>A23-B19-</td><td>A24-319-C1;</td><td>A24-B19-C2;</td><td>A24-B19-C3;</td><td>A24-B19-C4;</td>
<td>C4 5; A24-B19-C5;</td><td>C4 6; A24-B19-C6;</td><td>A24-319-C7;</td><td>A24-B19-C8;</td><td>A24-B19-C9;</td><td>A24-B19-</td>
<td>A24-B19-</td><td>A24-B19-</td><td>A24-319-</td><td>A24-B19-</td><td>A24-B19-</td><td>C1O; A24-B19-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A24-319-</td><td>A24-B19-</td><td>A24-319-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-319-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A24-B19-</td><td>A24-B19-</td><td>A24-319-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-319-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-319-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td><td>A24-B19-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
135
A25-B19-C1;
A25-B19-C7;
Α25-Β19C13;
Α25-Β19C19;
Α25-Β19C25;
Α25-Β19C31;
Α25-Β19C37;
Α25-Β19C4 3;
A26-B19-C3;
A26-B19-C9;
Α26-Β19C15;
Α26-Β19C21;
Α26-Β19C27;
Α26-Β19C33;
Α26-Β19C39;
Α26-Β19C4 5;
A27-B19-C5;
Α27-Β19Cll ;
A27-B19C17;
A27-B19C2 3;
A27-B19C2 9;
A27-B19C35;
A27-B19C41;
A28-B19-C1;
A28-B19-C7;
A28-B19C13;
A28-B19C19;
A28-B19C25;
A28-B19C31;
A23-B19C3? ;
A23-B19C4 3;
A1-B20-C3;
A1-B20-C9;
A1-B20-C15;
A1-B20-C21;
A25-B19-C2;
A25-B19-C8;
A25-B19C14;
A25-B19C20;
A25-B19C2 6;
A25-B19C32;
A25-B19C38;
A25-B19C4 4;
A26-B19-C4;
A26-B19C10;
A26-B19C16;
A26-B19C22;
A26-B19C28;
A26-B19C34;
A26-B19C4O;
A26-B19C4 6;
A27-B19-C6;
A27-B19C12;
A27-B19C18;
A27-B19C24;
A27-B19C30;
A27-B19C36;
A27-B19C4 2;
A28-B19-C2;
A28-B19-C8;
A28-B19C14;
A28-B19C20;
A28-B19C26;
A28-B19C32;
A28-B19C38;
A28-B19C4 4;
A1-B20-C4;
A1-B20-C10;
A1-B20-C16;
A1-B20-C22;
A25-B19-C3;
A25-B19-C9;
A25-B19C15;
A25-B19C21;
A25-B19C27;
A25-B19C33;
A25-B19C39;
A25-B19C4 5;
A26-B19-C5;
A26-B19Cll;
A26-B19C17;
A26-B19C23;
A26-B19C29;
A26-B19C35;
A26-B19C41;
A27-B19-C1;
A27-B19-C7;
A27-B19C13;
A27-B19C19;
A27-B19C25;
A27-B19C31;
A27-B19C37;
A27-B19C4 3;
A28-B19-C3;
A28-B19-C9;
A28-B19C15;
A28-B19C21;
A28-B19C27;
A28-319C33;
A28-B19C39;
A28-B19C4 5;
A1-B20-C5;
A1-B20-C11;
A1-B20-C17;
A1-B20-C23;
A25-B19-C4;
A25-B19C1O;
A25-B19C16;
A25-B19C22;
A25-B19C28;
A25-B19C34;
A25-B19C4O;
A25-B19C4 6;
A26-B19-C6;
A26-B19C12;
A26-B19C18;
A26-B19C2 4;
A26-B19C30;
A26-B19C36;
A26-B19C4 2;
A27-B19-C2;
A27-B19-C8;
A27-B19C14;
A27-B19C20;
A27-B19C2 6;
A27-B19C32;
A27-B19C38;
A27-B19C4 4;
A28-B19-C4;
A28-B19C1O;
A28-B19C16;
A28-B19C22;
A28-B19C28;
A28-B19C34;
A28-B19C4O;
A28-B19C4 6;
A1-B20-C6;
A1-B20-C12;
A1-B20-C18;
A1-B20-C24;
A25-B19-C5;
A25-B19Cll;
A25-B19C17;
A25-B19C23;
A25-B19C2 9;
A25-B19C35;
A25-B19C41;
A26-B19-C1;
A26-B19-C7;
A26-B19C13;
A26-B19C19;
A26-B19-, C25;
A26-B19C31;
A26-B19C37;
A26-B19C4 3;
A27-B19-C3;
A27-B19-C9;
A27-B19C15;
A27-B19C21;
A27-B19C27;
A27-B19C33;
A27-B19C39;
A27-B19C45;
A28-B19-C5;
A28-B19Cll;
A28-B19C17;
A28-B19C23;
A28-B19C29;
A28-B19C35;
A28-B19C41;
A1-B20-C1;
A1-B20-C7;
A1-B20-C13;
A1-B20-C19;
A1-B20-C25;
A25-B19-C6; A25-B19C12;
A25-B19C18;
A25-B19C24 ;
A25-B19C3O;
A25-B19C36;
A25-B19C4 2;
A26-B19-C2;
A26-B19-C8;
A26-B19C14 ;
A26-B19C20;
A26-B19C2 6;
A26-B19C32;
A26-B19C38;
A26-B19C4 4 ;
A27-B19-C4;
A27-B19C1O;
A27-B19C16;
A27-B19C22;
A27-B19C28;
A27-B19C34 ;
A27-B19C4O;
A27-B19C4 6;
A28-B19-C6; A28-B19C12;
A28-B19C18;
A28-B19C24 ;
A28-B19C30;
A28-B19C36;
A28-B19C4 2;
A1-B20-C2;
A1-B20-C8;
A1-B20-C14;
A1-B20-C20;
A1-B20-C26;
136
A1-B20-C27;
A1-B20-C33;
A1-B20-C39;
A1-B20-C45;
A2-B20-C5;
A2-B20-C11;
A2-B20-C17;
A2-B20-C23;
A2-B20-C29;
A2-B20-C35;
A2-B20-C41;.
A3-B20-C1;
A3-B20-C7;
A3-B20-C13;
A3-B20-C19;
A3-B20-C25;
A3-B20-C31;
A3-B20-C37;
A3-B20-C43;
A4-B20-C3;
A4-B20-C9;
A4-B20-C15;
A4-B2C-C21;
A4-B20-C27;
A4-B20-C33;
A4-B20-C39;
A4-B20-C45;
A5-B20-C5;
A5-B20-C11;
A5-B20-C17;
A5-B20-C23;
A5-B20-C29;
A5-B20-C35;
A5-B20-C41;
A6-B20-C1;
A6-B20-C7;
A6-B20-C13;
A6-B20-C19;
A6-B20-C25;
A6-B20-C31;
A6-B20-C37;
A6-B20-C43;
A7-B20-C3;
A7-B2C-C9;
A7-B2C-C15;
A7-B20-C21;
A7-B20-C27;
A7-B20-C33;
A7-B2C-C39;
A7-B20-C45;
A8-B2C-C5;
A8-B20-C11;
A8-B2C-C17;
A8-B20-C23;
A8-B20-C29;
A8-B20-C35;
A8-B2C-C41;
A9-B20-C1;
A9-B20-C7;
A9-B20-C13;
A9-B20-C19;
A9-B20-C25;
A9-B2C-C31;
A1-B20-C28;
A1-B20-C34;
A1-B20-C40;
A1-B20-C46;
A2-B20-C6;
A2-B20-C12;
A2-B20-C18;
A2-B20-C24;
A2-B20-C30;
A2-B20-C36;
A2-B20-C42;
A3-B20-C2;
A3-B20-C8;
A3-B20-C14;
A3-B20-C20;
A3-B20-C26;
A3-B20-C32;
A3-B20-C38;
A3-B20-C44;
A4-B20-C4;
A4-B20-C10;
A4-B20-C16;
A4-B20-C22;
A4-B20-C28;
A4-B20-C34;
A4-B20-C40;
A4-B20-C46;
A5-B20-C6;
A5-B20-C12;
A5-B20-C18;
A5-B20-C24;
A5-B20-C30;
A5-B20-C36;
A5-B20-C42;
A6-B20-C2;
A6-B20-C8;
A6-B20-C14;
A6-B20-C20;
A6-B20-C26;
A6-B20-C32;
A6-B20-C38;
A6-B20-C44;
A7-B20-C4;
A7-B20-C10;
A7-B20-C16;
A7-B20-C22;
A7-B20-C28;
A7-B20-C34;
A7-B20-C40;
A7-B20-C46;
A8-B20-C6;
A8-B20-C12;
A8-B20-C18; A8-B20-C24;
A8-B20-C30;
A8-B20-C36;
A8-B20-C42;
A9-B20-C2;
A9-B20-C8;
A9-B20-C14 ;
A9-B20-C20;
A9-B20-C26;
A9-B20-C32;
A1-B20-C29;
A1-B20-C35;
A1-B20-C41;
A2-B20-C1;
A2-B20-C7;
A2-B20-C13;
A2-B20-C19;
A2-B20-C25;
A2-B20-C31;
A2-B20-C37;
A2-B20-C43;
A3-B20-C3;
A3-B20-C9;
A3-B20-C15;
A3-B20-C21;
A3-B20-C27;
A3-B20-C33;
A3-B20-C39;
A3-B20-C45;
A4-B20-C5;
A4-B20-C11;
A4-B20-C17;
A4-B20-C23;
A4-B20-C29;
A4-B20-C35;
A4-B20-C41;
A5-B20-C1;
A5-B20-C7;
A5-B20-C13;
A5-B20-C19;
A5-B20-C25;
A5-B20-C31;
A5-B20-C37;
A5-B20-C43;
A6-B20-C3;
A6-B20-C9;
A6-B20-C15;
A6-B20-C21;
A6-B20-C27;
A6-B20-C33;
A6-B20-C39;
A6-B20-C45;
A7-B20-C5;
A7-B20-C11;
A7-B20-C17;
A7-B20-C23;
A7-B20-C29;
A7-B20-C35;
A7-B20-C41;
A8-B20-C1;
A8-B20-C7;
A8-B20-C13;
A8-B20-C19;
A8-B20-C25;
A8-B20-C31;
A8-B20-C37;
A8-B20-C43;
A9-B20-C3;
A9-B20-C9;
A9-B20-C15;
A9-B20-C21;
A9-B20-C27;
A9-B20-C33;
A1-B20-C30;
A1-B20-C36;
A1-B20-C42;
A2-B20-C2;
A2-B20-C8;
A2-B20-C14;
A2-B20-C20;
A2-B20-C26;
A2-B20-C32;
A2-B20-C38;
A2-B20-C44; A3-B20-C4;
A3-B20-C10;
A3-B20-C16;
A3-B20-C22;
A3-B20-C28;
A3-B20-C34;
A3-B20-C40;
A3-B20-C46; A4-B20-C6;
A4-B20-C12;
A4-B20-C18;
A4-B20-C24;
A4-B20-C30;
A4-B20-C36;
A4-B20-C42;
A5-B20-C2;
Á5-B20-C8;
A5-B20-C14;
A5-B20-C20;
A5-B20-C26;
A5-B20-C32;
A5-B20-C38;
A5-B20-C44; A6-B20-C4;
A6-B20-C10;
A6-B20-C16;
A6-B20-C22;
A6-B20-C28;
A6-B20-C34;
A6-B20-C40;
A6-B20-C46; A7-B20-C6;
A7-B20-C12;
A7-B20-C18;
A7-B20-C24;
A7-B20-C30;
A7-B20-C36;
A7-B20-C42;
A8-B20-C2;
A8-B20-C8;
A8-B20-C14;
A8-B20-C20;
A8-B20-C26;
A8-B20-C32;
A8-B20-C38;
A8-B20-C44; A9-B20-C4;
A9-B20-C10;
A9-B20-C16;
A9-B20-C22;
A9-B20-C28;
A9-B20-C34;
A1-B20-C31;
A1-B20-C37;
A1-B20-C43;
A2-B20-C3;
A2-B20-C9;
A2-B20-C15;
A2-B20-C21;
A2-B20-C27;
A2-B20-C33;
A2-B20-C39;
A2-B20-C45; A3-B20-C5;
A3-B20-C11;
A3-B20-C17;
A3-B20-C23;
A3-B20-C29;
A3-B20-C35;
A3-B20-C41;
A4-B20-C1;
A4-B20-C7;
A4-B20-C13;
A4-B20-C19;
A4-B20-C25;
A4-B20-C31;
A4-B20-C37;
A4-B20-C43;
A5-B20-C3;
A5-B20-C9;
A5-B20-C15;
A5-B20-C21;
A5-B20-C27;
A5-B20-C33;
A5-B20-C39;
A5-B20-C45; A6-B20-C5;
.A6-B20-C11;
A6-B20-C17;
A6-B20-C23;
A6-B20-C29;
A6-B20-C35;
A6-B20-C41;
A7-B20-C1;
A7-B20-C7;
A7-B20-C13;
A7-B20-C19;
A7-B20-C25;
A7-B20-C31;
A7-B20-C37;
A7-B20-C43;
A8-B20-C3;
A8-B20-C9;
A8-B20-C15;
A8-B20-C21;
A8-B20-C27;
A8-B20-C33;
A8-B20-C39;
A8-B20-C45;
A9-B20-C5;
A9-B20-C11;
A9-B20-C17;
A9-B20-C23;
A9-B20-C29;
A9-B20-C35;
A1-B20-C32;
A1-B20-C38;
A1-B20-C44;
A2-B20-C4;
A2-B20-C10;
A2-B20-C16;
A2-B20-C22;
A2-B20-C28;
A2-B20-C34;
A2-B20-C40;
A2-B20-C46;
A3-B20-C6;
A3-B20-C12;
A3-B20-C18;
A3-B20-C24;
A3-B20-C30;
A3-B20-C36;
A3-B20-C42;
A4-B20-C2;
A4-B20-C8;
A4-B20-C14;
A4-B20-C20;
A4-B20-C26;
A4-B20-C32;
A4-B20-C38;
A4-B20-C44;
A5-B20-C4;
A5-B20-C10;
A5-B20-C16;
A5-B20-C22;
A5-B20-C28;
A5-B20-C34;
A5-B20-C40;
A5-B20-C46;
A6-B20-C6;
A6-B20-C12;
A6-B20-C18;
A6-B20-C24;
A6-B20-C30;
A6-B20-C36;
A6-B20-C42;
A7-B20-C2;
A7-B20-C8;
A7-B20-C14;
A7-B20-C20;
A7-B20-C26;
A7-B20-C32;
A7-B20-C38;
A7-B20-C44;
A8-B20-C4;
A8-B20-C10;
A8-B20-C16;
A8-B20-C22;
A8-B20-C28;
A8-B20-C34;
A8-B20-C40;
A8-B20-C46;
A9-B20-C6;
A9-B20-C12;
A9-B20-C18;
A9-B20-C24;
A9-B20-C30;
A9-B20-C36;
137
A9-B20-C37;
A9-B20-C43;
A10-B20-C3;
A10-B20-C9;
Α10-Β20C15;
Α10-Β20C21;
Α10-Β20C27;
Α10-Β20C33;
Α10-Β20C39;
Α10-Β20C4 5;
A11-B20-C5;
Α11-Β20Cll;
A11-B20C17;
A11-B20C23;
A11-B20C2 9;
A11-B20C35;
A11-B20C41;
A12-B20-C1;
A12-B20-C7;
A12-B20C13;
A12-B20C19;
A12-B20C25;
A12-B20C31;
A12-320C37;
A12-B20C4 3;
A13-B20-C3;
A13-320-C9;
A13-B20C15;
A13-B20C21;
A13-B20C27;
A13-320C33;
A13-B20C39;
A13-B20C4 5;
A14-B20-C5;
A9-B20-C38;
A9-B20-C44;
A1O-B2O-C4;
A10-B20C10;
A10-B20C16;
A10-320C22;
A10-320C28;
A10-B20C34;
A10-B20C4O;
A10-320C4 6;
A11-320-C6;
All-320C12;
All-320C18;
A11-B20C2 4;
A11-B20C30;
All-320C36;
All-320C4 2;
A12-320-C2;
A12-320-C8;
A12-B20C14;
A12-320C20;
A12-320C26;
A12-320C32;
A12-320C38;
A12-320C4 4;
A13-320-C4;
Α13-Ξ20C1O;
A13-320C16;
A13-B20C22;
A13-B20C28;
Α13-Ξ20C34;
A13-320C4O;
A13-B20C4 6;
A14-320-C6;
A9-B20-C39;
A9-B20-C45;
A10-B20-C5;
A10-B20Cll;
A10-B20C17;
A10-B20C23;
A10-B20C29;
A10-B20C35;
A10-B20C41;
A11-B20-C1;
A11-B20-C7;
A11-B20C13;
A11-B20C19;
A11-B20C25;
A11-B20C31;
A11-B20C37;
A11-B20C4 3;
A12-B20-C3;
A12-B20-C9;
A12-B20C15;
A12-B20C21;
A12-B20C27;
A12-B20C33;
A12-B20C39;
A12-B20C4 5;
A13-B20-C5;
A13-B20Cll;
A13-B20C17;
A13-B20C23;
A13-B20C2 9;
A13-B20C35;
A13-B20C41;
A14-B20-C1;
A14-B20-C7;
A9-B20-C40;
A9-B20-C46;
A10-B20-C6; A10-B20C12;
A10-B20C18;
A10-B20C2 4 ;
A10-B20C30;
A10-B20C36;
A10-B20C4 2;
A11-B20-C2;
A11-B20-C8;
A11-B20C14;
A11-B20C20;
A11-B20C26;
A11-B20C32;
A11-B20C38;
A11-B20C4 4;
A12-B20-C4;
A12-B20C1O;
A12-B20C16;
A12-B20C22;
A12-B20C28;
A12-B20C34 ;
A12-B20C4O;
A12-B20C4 6;
A13-B20-C6; A13-B20C12;
A13-B20C18;
A13-B20C24;
A13-B20C30;
A13-B20C36;
A13-B20C4 2;
A14-B20-C2;
A14-B20-C8;
A9-B20-C41;
A10-B20-C1;
A10-B20-C7; A10-B20C13;
A10-B20C19;
A10-B20C2 5;
A10-B20C31;
A10-B20C37;
A10-B20C4 3;
A11-B20-C3;
A11-B20-C9;
A11-B20C15;
A11-B20C21;
A11-B20C27;
A11-B20C33;
A11-B20C39;
A11-B20C4 5;
A12-B20-C5;
A12-B20Cll;
A12-B20C17;
A12-B20C23;
A12-B2CC2 9;
A12-B20C35;
A12-B20C41;
A13-B20-C1;
A13-B20-C7;
A13-B20C13;
A13-B20C19;
A13-B20C25;
A13-B20C31;
A13-B20C37;
A13-B20C4 3;
A14-B20-C3;
A14-B20-C9;
A9-B20-C42;
A10-B20-C2;
A10-B20-C8;
A10-B20C14;
A10-B20C20;
A10-B20C2 6;
A10-B20C32;
A10-B20C38;
A10-B20C4 4 ;
A11-B20-C4;
A11-B20C1O;
A11-B20C16;
A11-B20C22;
A11-B20C28;
A11-B20C34;
A11-B20C4O;
A11-B20C4 6;
A12-B20-C6;
A12-B20C12;
A12-B20C18;
A12-B20C2 4 ;
A12-B20C30;
A12-B20C36;
A12-B20C4 2;
A13-B20-C2;
A13-B20-C8;
A13-B20C14 ;
A13-B20C20;
A13-B20C2 6;
A13-B20C32 ;
A13-320C38 ;
A13-B20C4 4 ;
A14-B20-C4;
A14-B20C1O;
138
<td>Α14-Β20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B2O-</td><td>A14-B20-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A14-B20-</td><td>A14-B20-</td><td>A14-B2O-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td>
<td>C23;</td><td>C24 ;</td><td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C2 8;</td>
<td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A14-B20-</td><td>A14-B2O-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td><td>A14-B20-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A15-B20-C1;</td><td>A15-B20-C2;</td><td>A15-B20-C3;</td><td>A15-B2O-C4;</td><td>A15-B20-C5;</td><td>A15-B20-C6;</td>
<td>A15-B20-C7;</td><td>A15-B20-C8;</td><td>A15-B20-C9;</td><td>A15-B20-</td><td>A15-B2O-</td><td>Α15-Ξ20-</td>
<td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>C1O; A15-B20-</td><td>Cll; A15-B20-</td><td>C12; A15-B20-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td>
<td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36; '</td>
<td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A15-B20-</td><td>A16-B20-C1;</td><td>A16-B20-C2;</td>
<td>C4 3; A16-B20-C3;</td><td>C4 4; A16-B20-C4;</td><td>C4 5; A16-B20-C5;</td><td>C4 6; A16-B20-C6;</td><td>A16-B20-C7;</td><td>A16-B20-C8;</td>
<td>A16-B20-C9;</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td>
<td>A16-B20-</td><td>C10; A16-B2O-</td><td>Cll; A16-B20-</td><td>C12; A16-B20-</td><td>C13; A16-B20-</td><td>C14; A16-B20-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A16-B20-</td><td>A16-B20-</td><td>A16-B2O-</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td><td>C25;</td><td>C2 6;</td>
<td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td><td>Α16-Ξ2Ο-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A16-B20-</td><td>A16-B2O-</td><td>A16-B20-</td><td>A16-B2O-</td><td>A16-B20-</td><td>A16-B20-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td><td>A16-B20-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A16-B20-</td><td>A16-B20-</td><td>A17-B20-C1;</td><td>A17-B20-C2;</td><td>A17-B20-C3;</td><td>A17-B20-C4;</td>
<td>C4 5; A17-B20-C5;</td><td>C4 6; A17-B20-C6;</td><td>A17-B20-C7;</td><td>A17-B20-C8;</td><td>A17-B20-C9;</td><td>A17-B20-</td>
<td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>C1O; A17-B20-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td><td>C15;</td><td>C16;</td>
<td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C2 2;</td>
<td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C2 8;</td>
<td>A17-B20-</td><td>A17-B20-</td><td>A17-B2O-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A17-B20-</td><td>A17-B20-</td><td>A17-B2O-</td><td>A17-B20-</td><td>A17-B20-</td><td>A17-B20-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A18-B20-C1;</td><td>A18-B2O-C2;</td><td>A18-B2O-C3;</td><td>A18-B20-C4;</td><td>A18-B20-C5;</td><td>A18-B20-C6;</td>
<td>A18-B20-C7;</td><td>A18-B20-C8;</td><td>A18-B20-C9;</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td>
<td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td><td>C1O; A18-B20-</td><td>Cll; A18-B20-</td><td>C12; A18-B20-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A18-B20-</td><td>A18-B20-</td><td>A18-B2O-</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
139
<td>Α18-Β20-</td><td>A18-B20-</td><td>A18-B2O-</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Α18-Β20-</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td><td>A18-B20-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C4 1;</td><td>C4 2;</td>
<td>A18-B20-</td><td>A18-B20-</td><td>A18-B2O-</td><td>A18-B20-</td><td>A19-B20-C1;</td><td>A19-B2O-C2;</td>
<td>C4 3; A19-B20-C3;</td><td>C4 4 ; A19-B20-C4;</td><td>C4 5; A19-B20-C5;</td><td>C4 6; A19-B20-C6;</td><td>A19-B20-C7;</td><td>A19-B20-C8;</td>
<td>A19-B20-C9;</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td><td>C25;</td><td>C26;</td>
<td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B2O-</td><td>A19-B20-</td><td>A19-B20-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td>
<td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td><td>A19-B20-</td>
<td>C39;</td><td>C4 0 ;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A19-B20-</td><td>A19-B20-</td><td>A20-B20-C1;</td><td>A20-B20-C2;</td><td>A20-B20-C3;</td><td>A2O-B2O-C4;</td>
<td>C4 5; A20-B20-C5;</td><td>C4 6; A20-B20-C6;</td><td>A20-B20-C7;</td><td>A20-B20-C8;</td><td>A20-B20-C9;</td><td>A20-B20-</td>
<td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>C1O; A20-B20-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-320-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td><td>A20-B20-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td><td>C4 5;</td><td>C4 6;</td>
<td>A21-B20-C1;</td><td>A21-B20-C2;</td><td>A21-B20-C3;</td><td>A21-B20-C4;</td><td>A21-B20-C5;</td><td>A21-320-C6;</td>
<td>A21-B20-C7;</td><td>A21-B20-C8;</td><td>A21-B20-C9;</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td>
<td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>C1O; A21-B20-</td><td>Cll; A21-B20-</td><td>C12; A21-B20-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td>
<td>C19;</td><td>C20; </td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>Α21-Ξ20-</td>
<td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C3O;</td>
<td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C3 6;</td>
<td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A21-B20-</td><td>A22-B20-C1;</td><td>A22-B20-C2;</td>
<td>C4 3; A22-B20-C3;</td><td>C4 4 ; A22-B20-C4;</td><td>C45; A22-B20-C5;</td><td>C4 6; A22-B20-C6;</td><td>A22-B20-C7;</td><td>A22-B20-C8;</td>
<td>A22-B20-C9;</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td>
<td></td><td>C1O;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14 ;</td>
<td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td>
<td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24 ;</td><td>C25;</td><td>C2 6;</td>
<td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C3O;</td><td>C31;</td><td>C32;</td>
<td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
140
<td>Α22-Β20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td><td>A22-B20-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α22-Β20-</td><td>A22-B20-</td><td>A23-B20-C1;</td><td>A23-B20-C2;</td><td>A23-B20-C3;</td><td>A23-B20-C4;</td>
<td>C4 5; A23-B20-C5;</td><td>C4 6; A23-B20-C6;</td><td>A23-B20-C7;</td><td>A23-B20-C8;</td><td>A23-B20-C9;</td><td>A23-B20-</td>
<td>Α23-Β20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>C10; A23-B20-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C2 8;</td>
<td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td><td>A23-B20-</td>
<td>C41;</td><td>C42;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A24-B20-C1;</td><td>A24-B20-C2;</td><td>A24-B20-C3;</td><td>A24-B20-C4;</td><td>A24-B20-C5;</td><td>A24-B20-C6;</td>
<td>A24-B20-C7;</td><td>A24-B20-C8;</td><td>A24-B20-C9;</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td>
<td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>C10; A24-B20-</td><td>Cll; A24-B20-</td><td>C12; A24-B20-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td>
<td>C2 5;</td><td>C26;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C3 6;</td>
<td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td>
<td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A24-B20-</td><td>A25-B20-C1;</td><td>A25-B20-C2;</td>
<td>C4 3; A25-B20-C3;</td><td>C4 4; A25-B20-C4;</td><td>C4 5; A25-B20-C5;</td><td>C4 6; A25-B20-C6;</td><td>A25-B20-C7;</td><td>A25-B20-C8;</td>
<td>A25-B20-C9;</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td>
<td></td><td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td>
<td>C21;</td><td>C22;</td><td>C2 3;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td>
<td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A25-B20-</td><td>A25-B2Ó-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td><td>A25-B20-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A25-B20-</td><td>A25-B20-</td><td>A26-B20-C1;</td><td>A26-B20-C2;</td><td>A26-B20-C3;</td><td>A26-B20-C4;</td>
<td>C4 5; A26-B20-C5;</td><td>C4 6; A26-B20-C6;</td><td>A26-B20-C7;</td><td>A26-B20-C8;</td><td>A26-B20-C9;</td><td>A26-B20-</td>
<td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>C10; A26-B20-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C2 8;</td>
<td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td>
<td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4 0;</td>
<td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td><td>A26-B20-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A27-B20-C1;</td><td>A27-B20-C2;</td><td>A27-B20-C3;</td><td>A27-B20-C4;</td><td>A27-B20-C5;</td><td>A27-B20-C6;</td>
141
A27-B20-C7;
Α27-Β20C13;
Α27-Β20C19;
Α27-Β20C2 5;
Α27-Β20C31;
Α27-Β20C37;
Α27-Β20C4 3;
A28-B20-C3;
A28-B20-C9;
Α28-Β20C15;
Α28-Β20C21;
Α28-Β20C27;
Α28-Β20C33;
Α28-Β20C39;
Α28-Β20C4 5;
A1-B21-C5;
A1-B21-C11;
A1-B21-C17;
A1-B21-C23;
A1-B21-C29;
A1-B21-C35;
A1-B21-C41;
A2-B21-C1;
A2-B21-C7;
A2-B21-C13;
A2-B21-C19;
A2-B21-C25;
A2-B21-C31; A2-B21-C37; A2-B21-C43;
A3-B21-C3;
A3-B21-C9;
A3-B21-C15;
A3-E21-C21;
A3-B21-C27 ;
A3-B21-C33;
A3-B21-C39;
A3-B21-C45;
A4-B21-C5;
A4-B21-C11;
A4-E21-C17;
A4-B21-C23;
A4-E21-C29;
A4-B21-C35;
A4-B21-C41;
A5-B21-C1;
A5-B21-C7;
A5-B21-C13;
A5-B21-C19;
<td>A27-B20-C8;</td><td>A27-B20-C9;</td><td>A27-B20C1O;</td><td>A27-B20Cll;</td><td>A27-B20- C12;</td>
<td>Α27-Β20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td>
<td>C14 ;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>Α27-Β20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td>
<td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td>
<td>Α27-Β20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td>
<td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>Ά27-Β20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td>
<td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>Α27-Β20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A27-B20-</td>
<td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>Α27-Β20-</td><td>A27-B20-</td><td>A27-B20-</td><td>A28-B20-C1;</td><td>A28-B20-C2;</td>
<td>C4 4; A28-B20-C4;</td><td>C4 5; A28-B20-C5;</td><td>C4 6; A28-B20-C6;</td><td>A28-B20-C7;</td><td>A28-B20-C8;</td>
<td>Α28-Β20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td>
<td>C10;</td><td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td>
<td>A28-B20-</td><td>A28-B20-</td><td>A28-B2O-</td><td>A28-B20-</td><td>A28-B20-</td>
<td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td>
<td>C22;</td><td>C2 3;</td><td>C2 4;</td><td>C25;</td><td>C2 6;</td>
<td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td>
<td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td>
<td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td><td>A28-B20-</td>
<td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>A28-B20-</td><td>A1-B21-C1;</td><td>A1-B21-C2;</td><td>A1-B21-C3;</td><td>A1-B21-C4;</td>
<td>C4 6; A1-B21-C6;</td><td>A1-B21-C7;</td><td>A1-B21-C8;</td><td>A1-B21-C9;</td><td>A1-B21-C10;</td>
<td>A1-B21-C12;</td><td>A1-B21-C13;</td><td>A1-B21-C14;</td><td>A1-B21-C15;</td><td>A1-B21-C16;</td>
<td>A1-B21-C18;</td><td>A1-B21-C19;</td><td>A1-B21-C20;</td><td>A1-B21-C21;</td><td>A1-B21-C22;</td>
<td>A1-B21-C24;</td><td>A1-B21-C25;</td><td>A1-B21-C26;</td><td>A1-B21-C27;</td><td>A1-B21-C28;</td>
<td>A1-B21-C30;</td><td>A1-B21-C31;</td><td>A1-B21-C32;</td><td>A1-B21-C33;</td><td>A1-B21-C34;</td>
<td>A1-B21-C36;</td><td>Ä1-B21-C37;</td><td>AÍ-B21-C38;</td><td>A1-B21-C39;</td><td>A1-B21-C40;</td>
<td>A1-B21-C42;</td><td>A1-B21-C43;</td><td>A1-B21-C44;</td><td>A1-B21-C45;</td><td>A1-B21-C46;</td>
<td>A2-B21-C2;</td><td>A2-B21-C3;</td><td>A2-B21-C4;</td><td>A2-B21-C5;</td><td>A2-B21-C6;</td>
<td>A2-B21-C8;</td><td>A2-B21-C9;</td><td>A2-B21-C10;</td><td>A2-B21-C11;</td><td>A2-B21-C12;</td>
<td>A2-B21-C14;</td><td>A2-B21-C15;</td><td>A2-B21-C16;</td><td>A2-B21-C17;</td><td>A2-B21-C18;</td>
<td>A2-B21-C20;</td><td>A2-B21-C21;</td><td>A2-B21-C22;</td><td>A2-B21-C23;</td><td>A2-B21-C24;</td>
<td>A2-B21-C26;</td><td>A2-B21-C27;</td><td>A2-B21-C28;</td><td>A2-B21-C29;</td><td>A2-B21-C30;</td>
<td>A2-B21-C32;</td><td>A2-B21-C33;</td><td>A2-B21-C34;</td><td>A2-B21-C35;</td><td>A2-B21-C36;</td>
<td>A2-B21-C38;</td><td>A2-B21-C39;</td><td>A2-B21-C40;</td><td>A2-B21-C41;</td><td>A2-B21-C42;</td>
<td>A2-B21-C44;</td><td>A2-B21-C45;</td><td>A2-B21-C46;</td><td>A3-B21-C1;</td><td>A3-B21-C2;</td>
<td>A3-B21-C4;</td><td>A3-B21-C5;</td><td>A3-B21-C6;</td><td>A3-B21-C7;</td><td>A3-B21-C8;</td>
<td>A3-B21-C10;</td><td>A3-B21-C11;</td><td>A3-B21-C12;</td><td>A3-B21-C13;</td><td>A3-B21-C14;</td>
<td>A3-B21-C16;</td><td>A3-B21-C17;</td><td>A3-B21-C18;</td><td>A3-B21-C19;</td><td>A3-B21-C20;</td>
<td>A3-B21-C22;</td><td>A3-B21-C23;</td><td>A3-B21-C24;</td><td>A3-B21-C25;</td><td>A3-B21-C26;</td>
<td>A3-E21-C28;</td><td>A3-B21-C29;</td><td>A3-B21-C30;</td><td>A3-B21-C31;</td><td>A3-B21-C32;</td>
<td>A3-B21-C34;</td><td>A3-B21-C35;</td><td>A3-B21-C36;</td><td>A3-B21-C37;</td><td>A3-B21-C38;</td>
<td>A3-B21-C40;</td><td>A3-B21-C41;</td><td>A3-B21-C42;</td><td>A3-B21-C43;</td><td>A3-B21-C44;</td>
<td>A3-B21-C46;</td><td>A4-B21-C1;</td><td>A4-B21-C2;</td><td>A4-B21-C3;</td><td>A4-B21-C4;</td>
<td>A4-B21-C6;</td><td>A4-B21-C7;</td><td>A4-B21-C8;</td><td>A4-B21-C9;</td><td>A4-B21-C1O;</td>
<td>A4-B21-C12;</td><td>A4-B21-C13;</td><td>A4-B21-C14;</td><td>A4-B21-C15;</td><td>A4-B21-C16;</td>
<td>A4-B21-C18;</td><td>A4-B21-C19;</td><td>A4-B21-C20;</td><td>A4-B21-C21;</td><td>A4-B21-C22;</td>
<td>A4-B21-C24;</td><td>A4-B21-C25;</td><td>A4-B21-C26;</td><td>A4-B21-C27;</td><td>A4-B21-C28;</td>
<td>A4-B21-C30;</td><td>A4-B21-C31;</td><td>A4-B21-C32;</td><td>A4-B21-C33;</td><td>A4-B21-C34;</td>
<td>A4-B21-C36;</td><td>A4-B21-C37;</td><td>A4-B21-C38;</td><td>A4-B21-C39;</td><td>A4-B21-C40;</td>
<td>A4-B21-C42;</td><td>A4-B21-C43;</td><td>A4-B21-C44;</td><td>A4-B21-C45;</td><td>A4-B21-C46;</td>
<td>A5-B21-C2;</td><td>A5-B21-C3;</td><td>A5-B21-C4;</td><td>A5-B21-C5;</td><td>A5-B21-C6;</td>
<td>A5-B21-C8;</td><td>A5-B21-C9;</td><td>A5-B21-C10;</td><td>A5-B21-C11;</td><td>A5-B21-C12;</td>
<td>A5-B21-C14;</td><td>A5-B21-C15;</td><td>A5-B21-C16;</td><td>A5-B21-C17;</td><td>A5-B21-C18;</td>
<td>A5-B21-C20;</td><td>A5-B21-C21;</td><td>A5-B21-C22;</td><td>A5-B21-C23;</td><td>A5-B21-C24;</td>
142
<td>A5-B21-C25;.</td><td>A5-B21-C26;</td><td>A5-B21-C27;</td><td>A5-B21-C28;</td><td>A5-B21-C29;</td><td>A5-B21-C30;</td>
<td>A5-B21-C31;</td><td>A5-B21-C32;</td><td>A5-B21-C33;</td><td>A5-B21-C34;</td><td>A5-B21-C35;</td><td>A5-B21-C36;</td>
<td>A5-B21-C37;</td><td>A5-B21-C38;</td><td>A5-B21-C39;</td><td>A5-B21-C40;</td><td>A5-B21-C41;</td><td>A5-B21-C42;</td>
<td>A5-B21-C43;</td><td>A5-B21-C44;</td><td>A5-B21-C45;</td><td>A5-B21-C46;</td><td>A6-B21-C1;</td><td>A6-B21-C2;</td>
<td>A6-B21-C3;</td><td>A6-B21-C4;</td><td>A6-B21-C5;</td><td>A6-B21-C6;</td><td>A6-B21-C7;</td><td>A6-B21-C8;</td>
<td>A6-B21-C9;</td><td>A6-B21-C10;</td><td>A6-B21-C11;</td><td>A6-B21-C12;</td><td>A6-B21-C13;</td><td>A6-B21-C14;</td>
<td>A6-B21-C15;</td><td>A6-B21-C16;</td><td>A6-B21-C17;</td><td>A6-B21-C18;</td><td>A6-B21-C19;</td><td>A6-B21-C20;</td>
<td>A6-B21-C21;</td><td>A6-B21-C22;</td><td>A6-B21-C23;</td><td>A6-B21-C24;</td><td>A6-B21-C25;</td><td>A6-B21-C26;</td>
<td>A6-B21-C27;</td><td>A6-B21-C28;</td><td>A6-B21-C29;</td><td>A6-B21-C30;</td><td>A6-B21-C31;</td><td>A6-B21-C32;</td>
<td>A6-B21-C33;</td><td>A6-B21-C34;</td><td>A6-B21-C35;</td><td>A6-B21-C36;</td><td>A6-B21-C37;</td><td>A6-B21-C38;</td>
<td>A6-B21-C39;</td><td>A6-B21-C40;</td><td>A6-B21-C41;</td><td>A6-B21-C42;</td><td>A6-B21-C43;</td><td>A6-B21-C4 4 ;</td>
<td>A6-B21-C45;</td><td>A6-B21-C46;</td><td>A7-B21-C1;</td><td>A7-B21-C2;</td><td>A7-B21-C3;</td><td>A7-B21-C4;</td>
<td>A7-B21-C5;</td><td>A7-B21-C6;</td><td>A7-B21-C7;</td><td>A7-B21-C8;</td><td>A7-B21-C9;</td><td>A7-B21-C10;</td>
<td>A7-B21-C11;</td><td>A7-B21-C12;</td><td>A7-B21-C13;</td><td>A7-B21-C14;</td><td>A7-B21-C15;</td><td>A7-B21-C16;</td>
<td>A7-B21-C17;</td><td>A7-B21-C18;</td><td>A7-B21-C19;</td><td>A7-B21-C20;</td><td>A7-B21-C21;</td><td>A7-B21-C22;</td>
<td>A7-B21-C23;</td><td>A7-B21-C24;</td><td>A7-B21-C25;</td><td>A7-B21-C26;</td><td>A7-B21-C27;</td><td>A7-B21-C28;</td>
<td>A7-B21-C29;</td><td>A7-B21-C30;</td><td>A7-B21-C31;</td><td>A7-B21-C32;</td><td>A7-B21-C33;</td><td>A7-B21-C34;</td>
<td>A7-B21-C35;</td><td>A7-B21-C36;</td><td>A7-B21-C37;</td><td>A7-B21-C38;</td><td>A7-B21-C39;</td><td>A7-B21-C40;</td>
<td>A7-B21-C41;</td><td>A7-B21-C42;</td><td>A7-B21-C43;</td><td>A7-B21-C44;</td><td>A7-B21-C45;</td><td>A7-B21-C46;</td>
<td>A8-B21-C1;</td><td>A8-B21-C2;</td><td>A8-B21-C3;</td><td>A8-B21-C4;</td><td>A8-B21-C5;</td><td>A8-B21-C6;</td>
<td>A8-B21-C7;</td><td>A8-B21-C8;</td><td>A8-B21-C9;</td><td>A8-B21-C10;</td><td>A8-B21-C11;</td><td>A8-B21-C12;</td>
<td>A8-B21-C13;</td><td>A8-B21-C14;</td><td>A8-B21-C15;</td><td>A8-B21-C16;</td><td>A8-B21-C17;</td><td>A8-B21-C18;</td>
<td>A8-B21-C19;</td><td>A8-B21-C20;</td><td>A8-B21-C21;</td><td>A8-B21-C22;</td><td>A8-B21-C23;</td><td>A8-B21-C24;</td>
<td>A8-B21-C25;</td><td>A8-B21-C26;</td><td>A8-B21-C27;</td><td>A8-B21-C28;</td><td>A8-B21-C29;</td><td>A8-B21-C30;</td>
<td>A8-B21-C31;</td><td>A8-B21-C32;</td><td>A8-B21-C33;</td><td>A8-B21-C34;</td><td>A8-B21-C35;</td><td>A8-B21-C36;</td>
<td>A8-B21-C37;</td><td>A8-B21-C38;</td><td>A8-B21-C39;</td><td>A8-B21-C40;</td><td>A8-B21-C41;</td><td>A8-B21-C42;</td>
<td>A8-B21-C43;</td><td>A8-B21-C44;</td><td>A8-B21-C45;</td><td>A8-B21-C46;</td><td>A9-B21-C1;</td><td>A9-B21-C2;</td>
<td>A9-B21-C3;</td><td>A9-B21-C4;</td><td>A9-B21-C5;</td><td>A9-B21-C6;</td><td>A9-B21-C7;</td><td>A9-B21-C8;</td>
<td>A9-B21-C9;</td><td>A9-B21-C10;</td><td>A9-B21-C11;</td><td>A9-B21-C12;</td><td>A9-B21-C13;</td><td>A9-B21-C14;</td>
<td>A9-B21-C15;</td><td>A9-B21-C16;</td><td>A9-B21-C17;</td><td>A9-B21-C18;</td><td>A9-B21-C19;</td><td>A9-B21-C20;</td>
<td>A9-B21-C21;</td><td>A9-B21-C22;</td><td>A9-B21-C23;</td><td>A9-B21-C24;</td><td>A9-B21-C25;</td><td>A9-B21-C26;</td>
<td>A9-B21-C27;</td><td>A9-B21-C28;</td><td>A9-B21-C29;</td><td>A9-B21-C30;</td><td>A9-B21-C31;</td><td>A9-B21-C32;</td>
<td>A9-B21-C33;</td><td>A9-B21-C34;</td><td>A9-B21-C35;</td><td>A9-B21-C36;</td><td>A9-B21-C37;</td><td>A9-B21-C38;</td>
<td>A9-B21-C39;</td><td>A9-B21-C40;</td><td>A9-B21-C41;</td><td>A9-B21-C42;</td><td>A9-B21-C43;</td><td>A9-B2L-C44;</td>
<td>A9-B21-C45;</td><td>A9-B21-C46;</td><td>A10-B21-C1;</td><td>A10-B21-C2;</td><td>A10-B21-C3;</td><td>A10-B21-C4;</td>
<td>A10-B21-C5;</td><td>A10-B21-C6;</td><td>A10-B21-C7;</td><td>. A10-B21-C8;</td><td>A10-B21-C9;</td><td>A10-E21- C1O;</td>
<td>Α10-Β21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>Α10-Ξ21-</td>
<td>C23;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>Α10-Ξ21-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-E21-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-B21-</td><td>A10-E21-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A11-B21-C1;</td><td>A11-B21-C2;</td><td>A11-B21-C3;</td><td>A11-B21-C4;</td><td>A11-B21-C5;</td><td>A11-B21-C6;</td>
<td>A11-B21-C7;</td><td>A11-B21-C8;</td><td>A11-B21-C9;</td><td>A11-B21C10;</td><td>A11-B21- Cll;</td><td>A11-B21C12;</td>
<td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-E21-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4;</td>
<td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-E21-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td>
<td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>Α11-Ξ21-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A11-B21-</td><td>A12-B21-C1;</td><td>A12-E21-C2;</td>
143
C4 3;
A12-B21-C3;
A12-B21-C9;
Α12-Β21C15;
Α12-Β21C21;
Α12-Β21C27;
Α12-Β21C33 ;
Α12-Β21C39;
Α12-Β21C4 5;
A13-B21-C5;
Α13-Β21Cll;
A13-B21C17;
A13-B21C23;
A13-B21C29;
A13-B21C35;
A13-B21C41;
A14-B21-C1;
A14-B21-C7;
A14-B21C13;
A14-B21C19;
A14-B21C25;
A14-B21C31;
A14-B21C37;
A14-B21C4 3;
A15-B21-C3;
A15-B21-C9;
A15-B21C15;
A15-B21C21;
A15-B21C27;
A15-B21C33;
A15-B21C39;
A15-B21C4 5;
A16-B21-C5;
A16-B21C4 4;
A12-B21-C4;
A12-B21C10;
A12-B21C16;
A12-B21C22;
A12-B21C28;
A12-B21C34 ;
A12-B21C4O;
A12-B21C4 6;
A13-B21-C6;
A13-B21C12;
A13-B21C18;
A13-B21C2 4 ;
A13-B21C30;
A13-B21C3 6;
A13-B21C4 2;
A14-B21-C2;
A14-B21-C8;
A14-B21C14;
A14-B21C20;
A14-B21C26;
A14-B21C32;
A14-B21C38;
A14-B21- .
C4 4; A15-B21-C4;
A15-B21C1O;
A15-B21C16;
A15-B21C22;
A15-B21C28;
A15-B21C34;
A15-B21C4O;
A15-B21C4 6;
A16-B21-C6;
A16-B21C4 5;
A12-B21-C5;
A12-B21Cll;
A12-B21C17;
A12-B21C23;
A12-B21C29;
A12-B21C35;
A12-B21C41;
A13-B21-C1;
A13-B21-C7;
A13-B21C13;
A13-B21C19;
A13-B21C25;
A13-B21C31;
A13-B21C37;
A13-B21C4 3;
A14-B21-C3;
A14-B21-C9;
A14-B21Č15;
A14-B21C21;
A14-B21C27;
A14-B21C33;
A14-B21C39;
A14-B21C45;
A15-B21-C5;
A15-B21Cll;
A15-B21C17;
A15-B21C2 3;
A15-B21C2 9;
A15-B21C35;
A15-B21C41;
A16-B21-C1;
A16-B21-C7;
A16-B21C4 6;
A12-B21-C6;
A12-B21C12;
A12-B21C18;
A12-B21C24;
A12-B21C30;
A12-B21C3 6;
A12-B21C4 2;
A13-B21-C2;
A13-B21-C8;
A13-B21C14 ;
A13-B21C20;
A13-B21C26;
A13-B21C32;
A13-B21C38;
A13-B21C4 4;
A14-B21-C4;
A14-B21C1O;
A14-B21C16;
A14-B21C22; '
A14-B21C28;
A14-B21C34;
A14-B21C4O;
A14-B21C4 6;
A15-B21-C6;
A15-B21C12;
A15-B21C18;
A15-B21C2 4;
A15-B21C30;
A15-B21C3 6;
A15-B21C4 2;
A16-B21-C2;
A16-B21-C8;
A16-B21A12-B21-C7;
A12-B21C13;
A12-B21C19;
A12-B21C25;
A12-B21C31;
A12-B21C37;
A12-B21C4 3;
A13-B21-C3;
A13-B21-C9;
A13-B21C15;
A13-B21C21;
A13-B21C27;
A13-B21C33;
A13-B21C39;
A13-B21C4 5;
A14-B21-C5;
A14-B21Cll;
A14-B21C17;
A14-B21C23;
A14-B21C29;
A14-B21C35;
A14-B21C41;
A15-B21-C1;
A15-B21-C7;
A15-B21C13;
A15-B21C19;
A15-B21C25;
A15-B21C31;
A15-B21C37;
A15-B21C4 3;
A16-B21-C3;
A16-B21-C9;
A16-B21A12-B21-C8;
A12-B21C14 ;
A12-B21C20;
A12-B21C2 6;
A12-B21C32; .
A12-B21C38;
A12-B21C4 4 ;
A13-B21-C4;
A13-B21C1O;
A13-B21C16;
A13-B21C22;
A13-B21C28;
A13-B21C34;
A13-B21C4 0;
A13-B21C4 6;
A14-B21-C6;
A14-B21C12;
A14-B21C18;
A14-B21C24 ;
A14-B21C30;
A14-B21C36;
A14-B21C42;·
A15-B21-C2;'
A15-B21-C8;
A15-B21C14;
A15-B21C20;
A15-B21C2 6;
A15-B21C32;
A15-B21C38;
A15-B21C4 4;
A16-B21-C4;
A16-B21C1O;
A16-B21144
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td>
<td>C23;</td><td>C24 ;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28 ;</td>
<td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td>
<td>C35;</td><td>C3 6;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A16-B21-</td><td>A16-B21-</td><td>A16-B21-</td><td>A16-B21- </td><td>A16-B21-</td><td>A16-321-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A17-B21-C1;</td><td>A17-B21-C2;</td><td>A17-B21-C3;</td><td>A17-B21-C4;</td><td>A17-B21-C5;</td><td>A17-B21-C6</td>
<td>A17-B21-C7;</td><td>A17-B21-C8;</td><td>A17-B21-C9;</td><td>A17-B21-</td><td>A17-B21-</td><td>Α17-Ξ21-</td>
<td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>C10; A17-B21-</td><td>Cll; A17-B21-</td><td>C12; A17-B21-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td>
<td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td>
<td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>Α17-Ξ21-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td>
<td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A17-B21-</td><td>A18-B21-C1;</td><td>A18-B21-C2</td>
<td>C4 3; A18-B21-C3;</td><td>C4 4; A18-B21-C4;</td><td>C4 5; A18-B21-C5;</td><td>C4 6; A18-B21-C6;</td><td>A18-B21-C7;</td><td>A18-B21-C8</td>
<td>A18-B21-C9;</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td>
<td>A18-B21-</td><td>C10; A18-B21-</td><td>Cll; A18-B21-</td><td>C12; A18-B21-</td><td>C13; A18-B21-</td><td>C14 ; A18-B21-</td>
<td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>Α18-Ξ21-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C2 4 ;</td><td>C25;</td><td>C2 6;</td>
<td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>Α18-Ξ21-</td>
<td>C2 7;</td><td>C28;</td><td>C2 9;</td><td>C30;</td><td>C31; '</td><td>C32;</td>
<td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>Α18-Ξ21-</td>
<td>C33;</td><td>C34;</td><td>C35 ;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td><td>A18-B21-</td>
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A18-B21-</td><td>A18-B21-</td><td>A19-B21-C1;</td><td>A19-B21-C2;</td><td>A19-B21-C3;</td><td>A19-B21-C4</td>
<td>C4 5; A19-B21-C5;</td><td>C4 6; A19-B21-C6;</td><td>A19-B21-C7;</td><td>A19-B21-C8;</td><td>A19-B21-C9;</td><td>Α19-Ξ21-</td>
<td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>C1O; A19-B21-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>’ C14;</td><td>C15; ’</td><td>C16;</td>
<td>A19-B21-</td><td>A19-B21- .</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>Α19-Ξ21-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>' C21;</td><td>C22;</td>
<td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C26;</td><td>C27;</td><td>C28;</td>
<td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>Α19-Ξ21-</td>
<td>C2 9;</td><td>C30;</td><td>C31.;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td>
<td>C35 ;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td><td>A19-B21-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A20-321-C1;</td><td>A20-B21-C2;</td><td>A20-B21-C3;</td><td>A2O-B21-C4;</td><td>A20-B21-C5;</td><td>A2O-B21-C6</td>
<td>A20-B21-C7;</td><td>A20-B21-C8;</td><td>A2C-B21-C9;</td><td>A20-B21-</td><td>A20-B21-</td><td>Α2Ο-Ξ21-</td>
<td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td><td>C1O; A20-B21-</td><td>Cll; A20-B21-</td><td>C12; Α2Ο-Ξ21-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td>
<td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td><td>A20-B21-</td>
5
C25;
Α20-Β21C31;
Α20-Β21C37;
Α20-Β21C43;
A21-B21-C3;
A21-B21-C9;
Α21-Β21C15;
Α21-Β21C21;
Α21-Β21C27;
Α21-Β21C33;
Α21-Β21C39;
Α21-Β21C4 5;
A22-B21-C5;
Α22-Β2ΙCll;
A22-B21C17;
A22-B21C23;
Ά22-Β21C2 9;
A22-B21C35;
A22-B21C41;
A23-B21-C1;
A23-B21-C7;
A23-B21C13;
A23-B21C19;
A23.-B21C25;
A23-B21C31;
A23-B21C37;
A23-B21C43;
A24-B21-C3;
A24-B21-C9;
A24-B21C15;
A24-B21C21;
A24-B21C27;
A24-B21C33;
A24-B21C2 6; A20-B21C32;
A20-B21C38;
A20-B21C4 4;
A21-B21-C4; A21-B21C10;
A21-B21C16; A21-B21C22;
A21-B21C28;
A21-B21C34; A21-B21C4 O ;
A21-B21C46; A22-B21-C6;
A22-B21C12;
A22-B21C18;
A22-B21C2 4;
A22-B21C3 O, A22-B21C36;
A22-B21C4 2;
A23-B21-C2;
A23-B21-C8;
A23-B21C14;
A23-B21C20;
A23-B21C26;
A23-B21C32;
A23-B21C38;
A23-B21C4 4;
A24-B21-C4;
A24-B21C1O;
A24-B21C16;
A24-B21C22;
A24-B21C28;
A24-B21C34;
A24-B21C27;
A20-B21C33;
A20-B21C39;
Ά20-Β21C4 5; A21-B21-C5;
A21-B21Cll; Ά21-Β21C17; A21-B21C23;
A21-B21C29;
A21-B21C35;
A21-B21C41;
A22-B21-C1;
A22-B21-C7;
A22-B21C13; A22-B21C19;
A22-B21C25;
A22-B21C31;
A22-B21C37;
A22-B21C4 3;
A23-B21-C3;
A23-B21-C9;
A23-B21C15;
A23-B21C21;
A23-B21C27;
A23-B21C33;
A23-B21C39;
A23-B21C4 5; A24-B21-C5;
A24-B21Cll;
A24-B21C17;
A24-B21C2 3;
A24-B21C29;
A24-B21C35;
A24-B21C28;
A20-B21C34;
A20-B21C4O;
A20-B21C4 6;
A21-B21-C6;
A21-B21C12;
A21-B21C18;
A21-B21C2 4;
A21-B21C30;
A21-B21C36;
A21-B21C4 2;
A22-B21-C2;
A22-B21-C8;
A22-B21C14;
A22-B21C20;
A22-B21C26;
A22-B21C32;
A22-B21C38;
A22-B21C4 4;
A23-B21-C4;
A23-B21C1O;
A23-B21C16;
A23-B21C22;
A23-B21C28;
A23-B21C34 ;
A23-B21C4O;
A23-B21C4 6;
A24-B21-C6;
A24-B21C12;
A24-B21C18;
A24-B21C2 4;
A24-B21C30;
A24-B21C3 6;
A24-B21C29;
A20-B21C35;
A20-B21C41;
A21-B21-C1;
A21-B21-C7;
A21-B21C13;
A21-B21C19;
A21-B21C2 5;
A21-B21C31;
A21-B21C37;
A21-B21C43;
A22-B21-C3;
A22-B21-C9;
A22-B21C15;
A22-B21C21;
A22-B21C27;
A22-B21C33;
A22-B21C39;
A22-B21C4 5;
A23-B21-C5;
A23-B21Cll;
A23-B21C17;
A23-B21C23;
A23-B21C29;
A23-B21C35;
A23-B21C41;
A24-B21-C1;
A24-B21-C7;
A24-B21C13;
A24-B21C19;
A24-B21C25;
A24-B21C31;
A24-B21C37;
A24-B21C30;
A20-B21C3 6;
A20-B21C4 2;
A21-B21-C2;
A21-B21-C8;
A21-B21C14 ;
A21-B21C2O;
A21-B21C2 6;
A21-B21C32;
A21-B21C38;
A21-B21C4 4;
A22-B21-C4;
A22-B21C1O;
A22-B21C16;
A22-B21C22;
A22-B21C28;
A22-B21C34;
A22-B21C4O;
A22-B21C4 6;
A23-B21-C6;
A23-B21C12;
A23-B21C18;
A23-B21C24;
A23-B21C30;
A23-B21C36; .
A23-B21C4 2;
A24-B21-C2;
A24-B21-C8;
A24-B21C14;
A24-B2IC20;
A24-B21C26;
A24-B21C32;
A24-B21C38;
A24-B21146
<td>C39;</td><td>C4 0;</td><td>C41;</td><td>C42;</td><td>C4 3;</td><td>C4 4 ;</td>
<td>Α24-Β21-</td><td>A24-B21-</td><td>A25-B21-C1;</td><td>A25-B21-C2;</td><td>A25-B21-C3;</td><td>A25-B21-C4</td>
<td>C4 5; A25-B21-C5;</td><td>C4 6; A25-B21-C6;</td><td>A25-B21-C7;</td><td>A25-B21-C8;</td><td>A25-B21-C9;</td><td>Ά25-Β21-</td>
<td>Α25-Β21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>C1O; A25-B21-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A25-B21-</td><td>A25-B21-</td><td>.A25-B21-</td><td>A25-B21-</td><td>A25-B2.1-</td><td>A25-B21-</td>
<td>C23;</td><td>C24 ;</td><td>C25;</td><td>' C26;</td><td>C27;</td><td>C28 ;</td>
<td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td>
<td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td><td>A25-B21-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A26-B21-C1;</td><td>A26-B21-C2;</td><td>A26-B21-C3;</td><td>A26-B21-C4;</td><td>A26-B21-C5;</td><td>A26-B21-C6</td>
<td>A26-B21-C7;</td><td>A26-B21-C8;</td><td>A26-B21-C9;</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td>
<td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>C1O; A26-B21-</td><td>Cll; A26-B21-</td><td>C12; A26-B21-</td>
<td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td><td>C17;</td><td>C18;</td>
<td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td>
<td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td><td>C23;</td><td>C24 ;</td>
<td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td>
<td>C2 5;</td><td>C2 6;</td><td>C27;</td><td>C28;</td><td>C2 9;</td><td>C30;</td>
<td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td>
<td>C31;</td><td>C32;</td><td>C33;</td><td>C34 ;</td><td>C35;</td><td>C36;</td>
<td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>Ά26-Β21-</td>
<td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td>
<td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A26-B21-</td><td>A27-B21-C1;</td><td>A27-B21-C2</td>
<td>C4 3; A27-B21-C3;</td><td>C4 4; A27-B21-C4;</td><td>C4 5; A27-B21-C5;</td><td>C4 6; A27-B21-C6;</td><td>A27-B21-C7;</td><td>A27-B21-C8</td>
<td>A27-B21-C9;</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td>
<td>A27-B21-</td><td>C10; A27-B21-</td><td>Cll; A27-B21-</td><td>C12; A27-B21-</td><td>C13; · A27-B21-</td><td>C14 ; A27-B21-</td>
<td>C15;</td><td>C16 ;</td><td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td>
<td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td>
<td>C21;</td><td>C22;</td><td>C23;</td><td>C24;</td><td>C25;</td><td>C2 6;</td>
<td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td>
<td>C27;</td><td>C28;</td><td>C29;</td><td>C30;</td><td>C31;</td><td>C32;</td>
<td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td>
<td>C33;</td><td>C34;</td><td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td>
<td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B21-</td><td>A27-B2.1-</td><td>A27-B21-</td>
<td>C39;</td><td>C4O;</td><td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td>
<td>A27-B21-</td><td>A27-B21-</td><td>A28-B21-C1;</td><td>A28-B21-C2;</td><td>A28-B21-C3;</td><td>A28-B21-C4</td>
<td>C4 5; A28-B21-C5;</td><td>C4 6; A28-B21-C6;</td><td>A28-B21-C7;</td><td>A28-B21-C8;</td><td>A28-B21-C9;</td><td>A28-B21-</td>
<td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>C1O; A28-B21-</td>
<td>Cll;</td><td>C12;</td><td>C13;</td><td>C14;</td><td>C15;</td><td>C16;</td>
<td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td>
<td>C17;</td><td>C18;</td><td>C19;</td><td>C20;</td><td>C21;</td><td>C22;</td>
<td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td>
<td>C2 3;</td><td>C24;</td><td>C25;</td><td>C2 6;</td><td>C27;</td><td>C28;</td>
<td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td>
<td>C2 9;</td><td>C30;</td><td>C31;</td><td>C32;</td><td>C33;</td><td>C34;</td>
<td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td>
<td>C35;</td><td>C36;</td><td>C37;</td><td>C38;</td><td>C39;</td><td>C4O;</td>
<td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td><td>A28-B21-</td>
<td>C41;</td><td>C4 2;</td><td>C4 3;</td><td>C4 4;</td><td>C4 5;</td><td>C4 6;</td>
<td>A1-B22;</td><td>A2-B22;</td><td>A3-B22;</td><td>A4-B22;</td><td>A5-B22;</td><td>A6-B22;</td>
<td>A7-B22;</td><td>A8-B22;</td><td>A9-B22;</td><td>A10-B22;</td><td>A11-B22;</td><td>A12-B22;</td>
147
<td>Α13-Β22;</td><td>Α14-Β22;</td><td>Α15-Β22;</td><td>Α16-Β22;</td><td>Α17-Β22;</td><td>Α18-Β22;</td>
<td>Α19-Β22;</td><td>Α20-Β22;</td><td>Α21-Β22;</td><td>Α22-Β22;</td><td>Α23-Β22;</td><td>Α24-Β22;</td>
<td>Α25-Β22;</td><td>Α26-Β22;</td><td>Α27-Β22;</td><td>Α28-Β22;</td><td>Α1-Β23;</td><td>Α2-Β23;</td>
<td>Α3-Β23;</td><td>Α4-Β23;</td><td>Α5-Β23;</td><td>Α6-Β23;</td><td>Α7-Β23;</td><td>Α8-Β23;</td>
<td>Α9-Β23;</td><td>Α10-Β23;</td><td>Α11-Β23;</td><td>Ά12-Β23;</td><td>Α13-Β23;</td><td>Α14-Β23;</td>
<td>Α15-Β23;</td><td>Α16-Β23;</td><td>Α17-Β23;</td><td>Α18-Β23;</td><td>Α19-Β23;</td><td>Α20-Β23;</td>
<td>Α21-Β23;</td><td>Α22-Β23;</td><td>Α23-Β23;</td><td>Α24-Β23;</td><td>Α25-Β23;</td><td>Α26-Β23;</td>
<td>Α27-Β23;</td><td>Α28-Β23;</td><td>Α1-Β24;</td><td>Α2-Β24;</td><td>Α3-Β24;</td><td>Α4-Β24;</td>
<td>Α5-Β24;</td><td>Α6-Β24;</td><td>Α7-Β24;</td><td>Α8-Β24;</td><td>Α9-Β24;</td><td>Α10-Β24;</td>
<td>Α11-Β24;</td><td>Α12-Β24;</td><td>Α13-Β24;</td><td>Α14-Β24;</td><td>Α15-Β24;</td><td>Α16-Β24;</td>
<td>Α17-Β24;</td><td>Α18-Β24;</td><td>Α19-Β24;</td><td>Α20-Β24;</td><td>Α21-Β24;</td><td>Α22-Β24;</td>
<td>Α23-Β24;</td><td>Α24-Β24;</td><td>Α25-Β24;</td><td>Ά26-Β24;</td><td>Α27-Β24;</td><td>Α28-Β24;</td>
<td>Α1-Β25;</td><td>Α2-Β25;</td><td>Α3-Β25;</td><td>Ά4-Β25;</td><td>Α5-Β25;</td><td>Α6-Β25;</td>
<td>Α7-Β25;</td><td>Α.8-Β25;</td><td>Α9-Β25;</td><td>Α10-Β25;</td><td>Α11-Β25;</td><td>Α12-325;</td>
<td>Α13-Β25;</td><td>Α14-Β25;</td><td>Α15-Β25;</td><td>Α16-Β25;</td><td>Α17-Β25;</td><td>Α18-Β25;</td>
<td>Α19-Β25;</td><td>Α20-Β25;</td><td>Α21-Β25;</td><td>Α22-Β25;</td><td>Α23-Β25;</td><td>Α24-Β25;</td>
<td>Α25-Β25;</td><td>Α26-Β25;</td><td>Α27-Β25;</td><td>Α28-Β25;</td><td>Α1-Β26;</td><td>Α2-Β26;</td>
<td>Α3-Β26;</td><td>Α4-Β26;</td><td>Α5-Β26;</td><td>Α6-Β26;</td><td>Α7-Β26;</td><td>Α8-Β26;</td>
<td>Α9-Β26;</td><td>Α10-Β26;</td><td>Α11-Β26;</td><td>Α12-Β26;</td><td>Α13-Β26;</td><td>Α14-Β26;</td>
<td>Α15-Β26;</td><td>Α16-Β26;</td><td>Α17-Β26;</td><td>Α18-Β26;</td><td>Α19-Β26;</td><td>Α20-Β26;</td>
<td>Α21-Β26;</td><td>Α22-Β26;</td><td>Α23-Β26;</td><td>Α24-Β26;</td><td>Α25-Β26;</td><td>Α26-Β26;</td>
<td>Α27-Β26;</td><td>Α28-Β26;</td><td>Α1-Β27;</td><td>Α2-Β27;</td><td>Α3-Β27;</td><td>Α4-Β27;</td>
<td>Α5-Β27;</td><td>Α6-Β27;</td><td>Α7-Β27;</td><td>Α8-Β27;</td><td>Α9-Β27;</td><td>Α10-Β27;</td>
<td>Α11-Β27;</td><td>Α12-Β27;</td><td>Α13-Β27;</td><td>Α14-Β27;</td><td>Α15-Β27;</td><td>Α16-Β27;</td>
<td>Α17-Β27;</td><td>Α18-Β27;</td><td>Α19-Β27;</td><td>Α20-Β27;</td><td>Α21-Β27;</td><td>Α22-Β27;</td>
<td>Α23-Β27;</td><td>Α24-Β27;</td><td>Α25-Β27;</td><td>Α26-Β27;</td><td>Α27-Β27;</td><td>Α28-Β27;</td>
<td>Α1-Β28;</td><td>Α2-Β28;.</td><td>Α3-Β28;</td><td>Α4-Β28;</td><td>Α5-Β28;</td><td>Α6-Β28;</td>
<td>Α7-Β28;</td><td>Α8-Β28;</td><td>Α9-Β28;</td><td>Α10-Β28;</td><td>Α11-Β28;</td><td>Α12-Β28;</td>
<td>Α13-Β28;</td><td>Α14-Β28;</td><td>Α15-Β28;</td><td>Α16-Β28;</td><td>Α17-Β28;</td><td>Α18-Β28;</td>
<td>Α19-Β28;</td><td>Α20-Β28;</td><td>Α21-Β28;</td><td>Α22-Β28;</td><td>Α23-Β28;</td><td>Α24-Β28;</td>
<td>Α25-Β28;</td><td>Α26-Β28;</td><td>Α27-Β28;</td><td>Α28-Β28;</td><td>Α1-Β29;</td><td>Α2-Β29;</td>
<td>Α3-Β29;</td><td>Α4-Β29;</td><td>Α5-Β29;</td><td>Α6-Β29;</td><td>Α7-Β29;</td><td>Α8-Β29;</td>
<td>Α9-Β29;</td><td>Α10-Β29;</td><td>Α11-Β29;</td><td>Α12-Β29;</td><td>Α13-Β29;</td><td>Α14-Β29;</td>
<td>Α15-Β29;</td><td>Α16-Β29;</td><td>Α17-Β29;</td><td>Α18-Β29;</td><td>Α19-Β29;</td><td>Α20-Β29;</td>
<td>Α21-Β29;</td><td>Α22-Β29;</td><td>Α23-Β29;</td><td>Α24-Β29;</td><td>Α25-Β29;</td><td>Α26-Β29;</td>
<td>Α27-Β29;</td><td>Α28-Β29;</td><td>Α1-Β30;</td><td>Α2-Β30;</td><td>Α3-Β30;</td><td>Α4-Β30;</td>
<td>Α5-Β30;</td><td>Α6-Β30;</td><td>Α7-Β30;</td><td>Α8-Β30;</td><td>Α9-Β30;</td><td>Α10-Β30;</td>
<td>Α11-Β30;</td><td>Α12-Β30;</td><td>Α13-Β30;</td><td>Α14-Β30;</td><td>Α15-Β30;</td><td>Α16-Β30;</td>
<td>Α17-Β30;</td><td>Α18-Β30;</td><td>Α19-Β30;</td><td>Α20-Β30;</td><td>Α21-Β30;</td><td>Α22-Β30;</td>
<td>Α23-Β30;</td><td>Α24-Β30;</td><td>Α25-Β30;</td><td>Α26-Β30;</td><td>Α27-Β30;</td><td>Α28-Β30;</td>
<td>Α1-Β31;</td><td>Α2-Β31;</td><td>Α3-Β31;</td><td>Α4-Β31;</td><td>Α5-Β31;</td><td>Α6-Β31;</td>
<td>Α7-Β31;</td><td>Α8-Β31;</td><td>Α9-Β31;</td><td>Α10-Β31;</td><td>Α11-Β31;</td><td>Α12-Β31;</td>
<td>Α13-Β31;</td><td>Α14-Β31;</td><td>Α15-Β31;</td><td>Α16-Β31;</td><td>Α17-Β31;</td><td>Α18-Β31;</td>
<td>Α19-Β31;</td><td>Α20-Β31;</td><td>Α21-Β31;</td><td>Α22-Β31;</td><td>Α23-Β31;</td><td>Α24-Β31;</td>
<td>Α25-Β31;</td><td>Α26-Β31;</td><td>Α27-Β31;</td><td>Α28-Β31;</td><td>Α1-Β32;</td><td>Α2-Β32;</td>
<td>Α3-Β32;</td><td>Α4-Β32;</td><td>Α5-Β32;</td><td>Α6-Β32;</td><td>Α7-Β32;</td><td>Α8-Β32;</td>
<td>Α9-Β32;</td><td>Α10-Β32;</td><td>Α11-Β32;</td><td>Α12-Β32;</td><td>Α13-Β32;</td><td>Α14-Β32;</td>
<td>Α15-Β32;</td><td>Α16-Β32;</td><td>Α17-Β32;</td><td>Α18-Β32;</td><td>Α19-Β32;</td><td>Α20-Β32;</td>
<td>Α21-Β32;</td><td>Α22-Β32;</td><td>Α23-Β32;</td><td>Α24-Β32;</td><td>Α25-Β32;</td><td>Α26-Β32;</td>
<td>Α27-Β32;</td><td>Α28-Β32;</td><td>Α29-Β33;</td><td>Α30-Β33;</td><td>Α31-Β33;</td><td>Α32-Β33;</td>
<td>Α33-Β33;</td><td>Α34-Β33;</td><td>Α35-Β33;</td><td>Α36-Β33;</td><td>Α37-Β33;</td><td>Α38-Β33;</td>
<td>Α39-Β33;</td><td>Α40-Β33;</td><td>Α41-333;</td><td>Α29-Β34;</td><td>Α30-Β34;</td><td>Α31-Β34;</td>
<td>Α32-Β34;</td><td>Α33-Β34;</td><td>Α34-Β34;</td><td>Α35-Β34;</td><td>Α36-Β34;</td><td>Α37-Β34;</td>
<td>Α38-Β34;</td><td>Α39-Β34;</td><td>Α40-Β34;</td><td>Ά41-Β34;</td><td>Α29-Β35;</td><td>Α30-Β35;</td>
<td>Α31-Β35;</td><td>Α32-Β35;</td><td>Α33-Β35;</td><td>Α34-Β35;</td><td>Α35-Β35;</td><td>Α36-Β35;</td>
<td>Α37-Β35;</td><td>Α38-Β35;</td><td>Α39-Β35;</td><td>Α40-Β35;</td><td>Α41-Β35;</td><td>Α29-Β36;</td>
<td>Α30-Β36;</td><td>Α31-Β36;</td><td>Α32-Β36;</td><td>Α33-Β36;</td><td>Α34-Β36;</td><td>Α35-Β36;</td>
<td>Α36-Β36;</td><td>Α37-Β36;</td><td>Α38-Β36;</td><td>Α39-Β36;</td><td>Α40-Β36;</td><td>Α41-Β36;</td>
<td>Α29-Β37;</td><td>Α30-Β37;</td><td>Α31-Β37;</td><td>Α32-Β37;</td><td>Α33-Β37;</td><td>Α34-Β37;</td>
<td>Α35-Β37;</td><td>Α36-Β37;</td><td>Α37-Β37;</td><td>Α38-Β37;</td><td>Α39-Β37;</td><td>Α40~Β37;</td>
<td>Α41-Β37;</td><td>Α29-Β38;</td><td>Α30-Β38;</td><td>Α31-Β38;</td><td>Α32-Β38;</td><td>Α33-Β38;</td>
<td>Α34-Β38;</td><td>Α35-Β38;</td><td>Α36-Β38;</td><td>Α37-Β38;</td><td>Α38-Β38;</td><td>Ά39-Β38;</td>
<td>Α40-Β38;</td><td>Α41-Β38;</td><td>Α29-Β39;</td><td>Α30-Β39;</td><td>Α31-Β39;</td><td>Α32-Β39;</td>
148
<td>A33-B39;</td><td>A34-B39;</td><td>A35-B39;</td><td>A36-B39;</td><td>A37-B39;</td><td>A38-B39;</td>
<td>A39-B39;</td><td>A40-B39;</td><td>A41-B39;</td><td>A29-B40;</td><td>A30-B40;</td><td>A31-B40;</td>
<td>A32-B40;</td><td>A33-B40;</td><td>A34-B40;</td><td>A35-B40;</td><td>A36-B40;</td><td>A37-B40;</td>
<td>A38-B40;</td><td>A39-B40;</td><td>A4O-B4O;</td><td>A41-B40;</td><td>A29-B41;</td><td>A30-B41;</td>
<td>A31-B41;</td><td>A32-B41;</td><td>A33-B41;</td><td>A34-B41;</td><td>A35-B41;</td><td>A36-B41;</td>
<td>A37-B41;</td><td>A38-B41;</td><td>A39-B41;</td><td>A40-B41;</td><td>A41-B41;</td><td>A29-B42;</td>
<td>A30-B42;</td><td>A31-B42;</td><td>A32-B42;</td><td>A33-B42;</td><td>A34-B42;</td><td>A35-B42;</td>
<td>A36-B42;</td><td>A37-B42;</td><td>A38-B42;</td><td>A39-B42;</td><td>A40-B42;</td><td>A41-B42;</td>
<td>A29-B43;</td><td>A30-B43;</td><td>A31-B43;</td><td>A32-B43;</td><td>A33-B43;</td><td>A34-B43;</td>
<td>A35-B43;</td><td>A36-B43;'</td><td>A37-B43;</td><td>A38-B43;</td><td>A39-B43;</td><td>A40-B43;</td>
<td>A41-B43;</td><td>A29-B44;</td><td>A30-B44;</td><td>A31-B44;</td><td>A32-B44;</td><td>A33-B44;</td>
<td>A34-B44;</td><td>A35-B44;</td><td>A36-B44;</td><td>A37-B44;</td><td>A38-B44;</td><td>A39-B44;</td>
<td>A4O-B44;</td><td>A41-B44.</td><td></td><td></td><td></td><td></td>
<td>so</td><td>for example</td><td>compound</td><td>referred to in</td><td>previous</td><td>list below</td>
<td>designation</td><td>A1-B1-C1</td><td>is a product</td><td>combinations</td><td>Al</td><td>from Table 1</td>
and Group B1 of Table 2 and Group C1 of Table 3, i
<img file="SK9012002A3_D0024.tif" />
Example 1 (a) below
Specific compounds of the present invention are:
6- (5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (3-bromophenyl) -5H-pyrrolo [2,3-b] pyrazine;
7-isopropyl-6-phenyl-5H-pyrrolo [2,3-b] pyrazine;
2- (4-bromophenyl) pyrrolo [2,3-b] pyrazine;
6- [4- (1,3-dioxan-2-yl) phenyl] -5H-pyrrolo [2,3-b] pyrazine;
6- [3- (1,3-dioxan-2-yl) phenyl] -5H-pyrrolo [2,3-b] pyrazine;
2- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -quinoline;
3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) isoquinoline;
6- [1-methyl-1H-indol-5-yl] -5H-pyrrolo [2,3-b] pyrazine;
149
6- (5-methoxy-1-methyl-1H-indol-3-yl) -2-methyl-5H-pyrrolo [2,3-b] pyrazine;
3-methyl-6- (l-methyl-H -indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (1-benzyl-5-methoxy-6-indol-3-yl) -5 H -pyrrolo [2,3- b] pyrazine;
6- (l-methyl-lH-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (1-methyl-lH-pyrrol-2-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (indolizine-l-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (3-methylindolizin-1-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (3-methyl-5-phenyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (5,6,7,8-tetrahydroindolizine-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (fur-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
dimethyl [4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] amine;
6- (5-methoxy-1-methyl-1H-indol-3-yl) -7-methyl-5H-pyrrolo [2,3-b] pyrazine;
6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazine;
6- (4-tert-butylphenyl) -7-methyl-5H-pyrrolo [2,3-b] pyrazine;
6- (3,4-dimethoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine;
6- (4-aminophenyl) -7-methyl-5H-pyrrolo [2,3-b] pyrazine;
6- [4- (1-methylethoxy) phenyl] -5H-pyrrolo [2,3-b] pyrazine;
6- (1H-methyl-2-methylthioimidazol-5-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (1-methyl-1H-indazol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (4-fluorophenyl) -5H-pyrrolo [2,3-b] pyrazine;
6- (4-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine;
150
7- (prop-2-enyl) -6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazine;
6- (4-methylthiophenyl) -5H-pyrrolo [2,3-b] pyrazine;
6- (3-Methoxy-phenyl) -5H-pyrrolo [2,3-b] pyrazine;
6- (l-methyl-lH-pyrazol-4-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (l-methyl-5-phenyl-lH-pyrazol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (pyridin-2-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (pyridin-4-yl) -5H-pyrrolo [2,3-b] pyrazine;
3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -propan-1-ol;
3- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-l-yl] -propan-l-ol;
[3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -ethanol;
2- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -ethanol;
3- (3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl) propylamine;
3- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-l-yl] propylamine;
N- {3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-l-yl] propyl} acetamide;
6- {1- [3- (morpholin-4-yl) propyl] -1 H -indol-3-yl} -5H-pyrrolo [2,3-b] pyrazine;
6- (1- (3- (piperid-1-yl) propyl) -1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
6- (1- (3- (pyridin-3-yloxy) propyl] -1 H -indol-3-yl} -5H-pyrrolo [2,3-b] pyrazine;
l-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indol-5-ol;
151
6- (2-chloro-5-methoxy-l-methyl-lH-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
- (5H-pyrrolo [2,3-b] pyrazin-6-yl) benzaldehyde;
4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -benzaldehyde;
[3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] methanol;
[4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] methanol;
6- (5-methoxy-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine;
2- [5-methoxy-3- (5,7-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -1- (morpholin-4-yl) -ethanone;
[5-methoxy-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -indol-1-yl] -acetic acid;
4-methoxy-2- (5-methoxy-l-methyl-lH-indol-3-yl) pyrrolo [2,3-b] pyridine;
4-methoxy-2- (5-methoxy-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine;
4-chloro-2- (4-tert-butylphenyl) -1H-pyrrolo [2,3-b] pyridine;
5-phenyl-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine;
2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -indol-1-yl] -1- (morpholin-4-yl) -ethanone;
1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic acid amide;
1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic acid methylamide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid methylamide;
152 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid (2-hydroxyethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid (2-morpholin-4-ylethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid (2-carbamoylethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid bis (2-hydroxyethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid amide;
1-methyl-3- (6-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [2-hydroxy-1,1-bis (hydroxymethyl) ethyl] amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid (2-hydroxy-1-hydroxymethyl-1-methylethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid (2,3-dihydroxypropyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid (2-hydroxy-1,1-dimethylethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid (2-hydroxy-1-hydroxymethylethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid (2-carbamoylethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid (2-hydroxyethyl) amide;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid (1H-1,2,4-triazol-3-yl) amide;
1-methyl-3- (2-hydroxy-1-hydroxymethylethyl) amide (1H153
pyrrolo [2,3-b] pyridin-2-yl) -1 H-indole-6-carboxylic acid;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid (2-hydroxy-1,1-dimethylethyl) amide;
[6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -N-methylpropionamide;
3- [6- (4-tert-Butyl-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -N, N-dimethyl-propionamide;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-methoxyethylamide;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2- (thien-2-yl) ethylamide;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-fluoroethylamide;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazine- 2-carboethoxyethylamide)
-6-yl) -1H-indole-5-carboxylic acid;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid (hydroxymethyl) carbomethoxymethylamide;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-hydroxyethylamide;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid methylamide;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -12H-indole-5-carboxylic acid dimethylamide;
[1-Methyl-3- (5,7-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yl] - (morpholin-4-yl) ketone;
4-hydroxy- {1- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yl] carbonylpiperidine;
154 3- [1-Methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yl] carbonylaminopropionic acid methylamide;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 3-hydroxypropylamide;
3- {6- [4- (1-Methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionic acid methylamide;
3- [6- (4-Methoxy-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -propionic acid methylamide;
3- (6- (4- (1-methyl) ethoxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionamide;
3- {6- (4-hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionamide;
3- [6- (4-Fluoro-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -propionic acid methylamide;
[1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] acetic acid;
2- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propionic acid;
1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic acid;
1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5-carboxylic acid;
l-methyl-3- (IH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-ol;
1- {1- (cyclobutanecarboxylic acid) -3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yloxy} cyclobutanecarboxylic acid acid;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid;
155 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yl] propionic acid;
1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid;
[2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenoxy] -acetic acid;
3- [2-dimethylamino-5- (5-t-pyrrolo [2,3-b] pyrazin-6-yl) -phenyl] -propionic acid;
2- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] ethanol;
2- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] propan-1-ol;
{1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] cyclobutyl] methanol;
2- (6-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) ethanol;
3- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yl] carbonylaminopropionic acid;
2- [2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenoxy] -ethanol;
3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenyl] -propan-1-ol;
3- {6- [4- (1-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl} propanol;
2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine;
3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] propane-1,2-diol;
3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] propan-1-ol;
156
3- [l-methyl-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yloxy] -propan-2-ol;
2- [1-methyl-5- (2H-tetrazol-5-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine;
2- [1-methyl-5- (2-methyl-2H-tetrazol-5-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine;
2- [l-methyl-5- (l-methyl-lH-tetrazol-5-yl) -lH-indol-3-yl] -lH-pyrrolo [2,3-b] pyridine;
1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yl] ethanone;
- (5,6-dimethoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine;
2- [5- (2-methoxy-1-methyl-ethoxy) -1-methyl-1H-indol-3-yl] -1H-pyrrole-
[2,3-b] pyridine;
2- [1-methyl-5- (5-methyl-1,2,4-oxadiazol-3-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine;
3- [6-methoxy-1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] propane-1,2-diol;
6-methoxy-1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-ol;
2- (5-methoxy-l-methyl-lH-indol-3-yl) -4-phenyl-lH ~ pyrrolo [2,3-b] pyridine ·;
2- [5- (pyridin-4-yl) -l-methyl-lH-indol-3-yl] -lH-pyrrolo [2,3-b] pyridine;
2- (5-methoxy-l-methyl-lH-indol-3-yl) pyrrolo [2,3-b] pyridine-4-carbonitrile;
4-chloro-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine;
1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-ylamine;
157
N- [1-mety1-3- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-yl] methanesulfonamide;
N- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yl] acetamide;
{1- [5- (1-hydroxymetylcyklobutoxy) -3- (lH-pyrrolo [2,3-b] pyridin-2- <sup>1 </sup>yl) -indol-l-yl] cyklobutylJmetanol;
{[1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -lH-indol-5-yloxy] cyklobutylJmetanol;
2- [6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] ethyl-2H-tetrazole;
3- [6- (4-tert-Butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -2H-propionitrile;
3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] -propionamide;
3- [6- (4-tert-Butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid;
3- {6- [4- (1-Methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl} propionic acid;
3- [6- (4-Fluoro-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -propionic acid;
3- [6- (4-Methoxy-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -propionic acid;
3- [6- (4-tert-Butyl-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -propan-1-ol;
[2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenoxy] -acetic acid ethyl ester;
2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenol;
158
3-fluoro-2- (5-methoxy-1-methyl-1H-indol-3-yl) pyrrolo [2,3-b] pyridine;
3- {6- (4-hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl} -propionic acid;
t 3- {6- (4-Hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid ethyl ester;
2- (5-methoxy-1H-indol-3-yl) -1H-pyrrolo [2,3-h] pyridine-4-carbonitrile;
6- (4-methylsulfinylphenyl) -5H-pyrrolo [2,3-b] pyrazine;
6- (4-methylsulfonylphenyl) -5H-pyrrolo [2,3-b] pyrazine;
3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propylamine;
N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} acetamide;
N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} cyclopropylcarboxylic acid amide;
N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl] butyramide;
N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) -propyl} methoxyacetamide;
N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} thien-2-ylcarboxylic acid amide;
N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) -propyl} -N'-propylurea;
N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} -N '- (carboethoxymethyl) urea;
N- {3- (6- (4-tert-butylphenyl) -5 H -pyrrolo [2,3- b] pyrazin-7-yl) -propyl} -1 ', N'-diethylurea;
N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl] methanesulfonamide;
N- {3- (6- (4-tert-butylphenyl) -577-pyrrolo [2,3-b] pyrazin-7-yl) propyl} thien-2-ylsulfonamide;
N- (3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} dimethylisoxazol-4-ylsulfonamide);
N- {3- (6- (4- tert -butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propyl} -1-methylimidazol-4-ylsulfonamide;
and the corresponding N-oxides and prodrugs thereof; and pharmaceutically acceptable salts and solvates (e.g., hydrates) of these compounds and their N-oxides and prodrugs.
Preferred compounds of the present invention are:
6- (5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine (Compound A1-B1-C1);
1- [1-methyl-3- (ΙΗ-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic acid amide (compound A2-B1-C31);
2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine-4-carbonitrile (Compound A3-B1-C28);
(1- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-y); 1'-1H-indol-5-yloxy] cyclobutyl] methanol (compound A1-B1-C28);
and the corresponding N-oxides and prodrugs thereof; and preferred acceptable salts and solvates (eg, hydrates) of these compounds and their N-oxides and prodrugs.
The compounds of the present invention possess useful pharmacological activity and are therefore used in pharmaceutical compositions and further used in the treatment of patients suffering from certain health problems. The present invention
160 therefore, in another aspect, it provides compounds of the present invention and compositions containing them for use in therapy.
The compounds of the present invention block the catalytic activity of kinases according to the tests described in literature and in vitro procedures described in the next section of the present invention. The results of these assays are considered to be consistent with the pharmacological activity in humans and other mammals. Thus, in another embodiment, the present invention provides compounds of the present invention and compositions comprising them for use in treating patients suffering from conditions that can be ameliorated by administration of protein kinase inhibitors (eg, Syk, FAK, DRC, Or Aurora2) . For example, the compounds of the present invention are useful in the treatment of inflammatory diseases such as asthma; inflammatory dermatoses (eg, psoriasis, dermatitis herpetiformis, eczema, necrotization and cutaneous vasculitis, blisters); allergic rhinitis and allergic conjunctivitis; ligament inflammations including arthritis, rheumatoid arthritis and other arthritic conditions such as rheumatoid spondylitis, gout, traumatic arthritis, rubella arthritis, psoriatic arthritis and osteoarthritis. The compounds are also useful in the treatment of chronic obstructive pulmonary disease (COPD), acute synovitis, autoimmune diabetes, autoimmune encephalomyelitis, colitis, atherosclerosis, peripheral vascular disease, cardiovascular disease, multiple sclerosis, restenosis, myocarditis, B cell lymphomas, systemic lupus erythematosus, a disease associated with the reaction graft versus host and other graft rejection cases, cancer and tumors (such as colorectal cancer, prostate, breast, thyroid, intestine and lung cancer) and inflammatory bowel disease. In addition, the compounds are useful as tumor anti-angiogenic agents.
A special presentation of the treatment method of the present invention is the treatment of asthma.
161
<td>Another</td><td>a special implementation</td><td>way</td><td>would</td><td>present</td>
<td>Of the invention is</td><td>Treatment of psoriasis.</td><td></td><td></td><td></td>
<td>Another</td><td>a special implementation</td><td>way</td><td>would</td><td>present</td>
<td>Of the invention is</td><td>Treatment of ligament inflammation.</td><td></td><td></td><td></td>
<td>Another</td><td>a special implementation</td><td>way</td><td>would</td><td>present</td>
<td>Of the invention is</td><td colspan="3">Treatment of inflammatory bowel disease.</td><td></td>
A special presentation of the treatment method of the present invention is the treatment of cancer and tumors.
Another object of the present invention is the method of treating humans or animals suffering from conditions that can be improved by administering a protein kinase inhibitor (eg, Syk, FAK, KDR or Aurora2), eg amount of the compound of the invention or composition of the compound of the present invention to the patient. An "effective amount" means a compound of the present invention capable of inhibiting the catalytic activity of a protein kinase such as Syk, FAK, KDR or Aurora2, and producing the desired beneficial effect.
The term treatment here includes prophylactic treatment as well as treatment of conditions that have already occurred.
The present invention also encompasses pharmaceutical compositions containing at least one compound of the present invention in association with a preferred carrier or excipient.
The compounds of the present invention may be administered by any suitable route. In practice, the compounds of the present invention may generally be administered parenterally, topically, rectally, orally or by inhalation, primarily orally.
The compositions of the present invention can be prepared by conventional procedures using one or more acceptable excipients. The ingredients include, but are not limited to, diluents,
162 sterile aqueous media and various non-toxic organic solvents. The compositions may also contain tablets, pills, granules, powders, aqueous solutions or suspensions, injectable solutions, beverages or syrups, and may contain one or more agents selected from the group consisting of sweetening, flavoring, coloring or stabilizing agents to provide and acceptable acceptable. preparation. The choice of carrier and determination of the amount of active agent in the carrier is generally determined by the solubility and chemical properties of the active compound, the particular mode of administration and pharmaceutical practice. For example, excipients such as lactose, sodium citrate, calcium carbonate, dibasic calcium phosphate and disintegrants such as starch, alginic acid and some complex silicates associated with lubricants such as magnesium stearate, sodium lauryl sulfate and talc may be used in the preparation of tablets . Lactose and high molecular weight polyethylene glycols are suitable for the preparation of capsules. When aqueous suspensions are used, they may contain emulsifiers or suspending agents. Diluents such as sucrose, ethanol, polyethylene glycol, propylene glycol, glycerol and chloroform or mixtures thereof may also be used.
For parenteral administration, emulsions, suspensions or solutions of the products of the present invention in vegetable oil, for example sesame oil, peanut oil or olive oil, or aqueous organic solutions such as water and propylene glycol, injectable organic esters such as ethyl oleate, and sterile aqueous solutions are used. preferred acceptable salts. Salts of the present invention are especially suitable for administration by muscle or subcutaneous injection. Aqueous solutions containing salt solutions in pure distilled water may be used for intravenous administration if their pH is appropriately adjusted to be buffered and isotonic with sufficient glucose or sodium chloride and sterilized by heat, irradiation or microfiltration.
Gels (based on water or alcohol), creams or ointments containing compounds of the present invention 163 may be used for topical administration. The compounds of the present invention may also be in a gel or matrix for administration in the form of patches, allowing controlled release of compounds across the transdermal barrier.
When administered by inhalation, the compounds of the present invention are dissolved or suspended in a carrier suitable for use in a nebulizer or aerosol, or can be absorbed or absorbed on a solid carrier suitable for use in a dry powder inhaler.
Solid compositions for rectal administration include suppositories that are prepared by known methods and contain at least one compound of the present invention.
The proportion of active ingredient in the composition of the present invention may vary, but must be such that the correct dosage is obtained. Of course, several dosage units may also be administered at the same time. The dose employed will be determined by the physician and will depend on the desired therapeutic effect, the mode of administration, the duration of treatment and the condition of the patient. In adults, the dose is generally from 0.001 to 50, suitably from 0.001 to 5 mg / kg, of body weight per day by inhalation; for oral administration from 0.01 to 100, suitably from 0.1 to 70, more preferably from 0.5 to 10 mg / kg body weight per day; and for intravenous administration from 0.001 to 10, suitably from 0.01 to 1 mg / kg body weight per day. In each particular case, the dosage will be determined according to the features of the subject to be treated, such as age, weight, general health, and other features that may affect the efficacy of the drug.
The compounds of the present invention may be administered as often as necessary to achieve the desired therapeutic effect. Some patients may respond quickly to a higher or lower dose and may require a much lower maintenance dose. In other patients, long-term treatment may be required, depending on the physiological requirements of each particular patient, with 1 to 4 doses per day administered. Active product is
164 It can generally be administered orally 1 to 4 times a day. However, for some patients, it may be necessary to exceed 1 or 2 doses per day.
The compounds of the present invention can be prepared by application or adaptation of known methods, by which the methods or methods described are used, for example RC Larock, Comprehensive Organic Transformations, VCH Publishers, 1989.
In the reactions described below, it may be necessary to protect reactive functional groups, such as hydroxy, amino, imino, thio, or carboxyl groups, if these are desired in the final product to prevent unwanted participation in the reactions. Conventional protecting groups may be employed in accordance with conventional practice, for example, see TW Greene and PGM Wuts, & quot; Protective Groups in Organic Chemistry, John Wiley & amp; Sons, 1991.
Compounds of formula I wherein R1<sup>1</sup>, R<sup>2</sup> and R<sup>3</sup> have already been defined, and X<sup>1</sup> is a nitrogen atom or a CH group, may be prepared by application or adaptation of the procedures described in David et al., Tetrahedron, 48, 939-952 (1992), for example:
(i) Reacting a compound of Formula III
<img file="SK9012002A3_D0025.tif" />
where R<sup>2</sup> and R<sup>3</sup> have already been defined and X<sup>1</sup> is nitrogen or CH, with a suitable base, such as lithium diisopropylamide (or butyllithium), in an inert solvent such as tetrahydrofuran at a temperature from -26 ° C;
(ii) reacting the resulting anion with the nitrile of Formula IV
165
R<sup>1</sup>—CN (<sup>IV</sup>>
where R<sup>1</sup> as defined above, at a temperature of -15 ° C to room temperature.
This process is well suited for the preparation of compounds of formula I wherein R @ 1<sup>1</sup> R 3 is an optionally substituted N-methylindol-3-yl group, R 3<sup>2</sup> and R<sup>3</sup> are hydrogen and X<sup>1</sup> is nitrogen or CH.
Compounds of formula I wherein R1<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> as already defined, may also be prepared by application or adaptation of the procedures described by Chang and Bag, J. Org. Chem., 21, 7030-7032 (1995), for example by reaction of a compound of Formula V
<img file="SK9012002A3_D0026.tif" />
X<sup>2</sup> (R) where R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> have already been defined and X<sup>2</sup> is a halogen atom, suitably an iodine atom, or a triflate, with a boronic acid of formula VI
R<sup>1</sup>—B (OH) <sub>2</sub> (R) where R<sup>1</sup> is a group that has already been defined. The coupling reaction can be advantageously carried out, for example, in the presence of a complex metal catalyst such as tetrakis (triphenylphosphine) palladium (0), and sodium bicarbonate in aqueous dimethylformamide at a temperature up to the boiling point of the mixture.
The compounds of the present invention may also be prepared by interconversion of other compounds of the present invention.
Thus, for example, a compound of formula (I) contains
166 The carboxyl group can be prepared by hydrolysis of the corresponding ester. Hydrolysis may conveniently be carried out by alkali using an alkali metal hydroxide such as lithium hydroxide or an alkali metal carbonate such as potassium carbonate in the presence of an aqueous / organic solvent mixture using an organic solvent such as dioxane, tetrahydrofuran or methanol at room temperature to boiling point. The ester hydrolysis can also be carried out in an acidic manner using an inorganic acid such as hydrochloric acid in the presence of an aqueous / inert organic solvent mixture using an organic solvent such as dioxane or tetrahydrofuran at a temperature of 50 ° C to 80 ° C ° C.
Another example of the preparation of a compound of Formula I containing a carboxyl group is the acid catalyzed removal of the tert-butyl group from the corresponding tert-butyl ester using standard reaction conditions, for example by reaction with trifluoroacetic acid at room temperature.
Another example of the preparation of a compound of Formula I containing a carboxyl group is the hydrogenation of the corresponding benzyl ester. The reaction may be carried out in the presence of ammonium formate and a suitable metal catalyst, for example palladium, on an inert support such as coal, preferably in a solvent such as methanol or ethanol, at a temperature around the boiling point of the mixture. . Alternatively, the reaction may be carried out in the presence of a suitable metal catalyst, for example platinum or palladium, optionally anchored on an inert support such as coal, preferably in a solvent such as methanol or ethanol.
As an example of interconversion, compounds of formula I containing a -C (= O) -NY group can be used<sup>1</sup>Y<sup>2</sup> prepared by coupling a compound of formula I containing a carboxyl group with an amine of HNYY<sup>2</sup>to obtain an amide bond using standard peptide synthesis techniques, for example by coupling in the presence of O- (7-azabenzotriazol-1-yl) -1,1,3,3-tetra-177 methyluronium hexafluorophosphate and triethylamine (or diisopropylethylamine) in tetrahydrofuran (or dimethylformamide)) at room temperature. Coupling may be accomplished by reacting a compound of Formula I containing a carboxyl group with N - {(dimethylamino) (1H-1,2,3-triazolo [4,5-b] pyrid-1-yl) methylene} -N- methylmethanammoniumhexafluorophosphate With an N-oxide in the presence of a suitable base such as diisopropylethylamine in an inert solvent such as dimethylformamide at room temperature and subsequent reaction with an amine of formula HNY Y (to prepare a compound of formula I containing a -C (= O) -NH group<sub>2</sub> ammonium chloride may be used).
As another example of preparation by interconversion, compounds of formula I containing a -CH group can be prepared<sub>2</sub>OH would reduce the corresponding compound of formula I containing -CHO or -CO<sub>2</sub>R<sup>7</sup> (where R<sup>7</sup> is lower alkyl). For example, the reduction may conveniently be carried out by reaction with lithium aluminum hydride in an inert solvent such as tetrahydrofuran at room temperature to the boiling point of the mixture.
A further example of the interconversion preparation may be the preparation of a compound of formula I wherein R 1 is R 2<sup>1</sup> is aryl or heteroaryl substituted with -CO<sub>2</sub>Me:
(i) reacting a compound of formula (I) wherein R 1<sup>1</sup> is an aryl or heteroaryl group substituted with a hydroxy group, with N-phenyltrifluoromethanesulfonimide in the presence of a suitable base such as triethylamine in an inert solvent such as dichloromethane at -78 ° C;
(ii) reacting the resulting triflate with carbon monoxide in the presence of a suitable catalyst (eg, palladium acetate), 1,3-bis (diphenylphosphino) propane, triethylamine, and methanol in an inert solvent such as dimethylformamide at 100 kPa (1) atm) at room temperature.
This process is particularly suitable for the preparation of compounds of general formula (I) in which R @ 1<sup>1</sup> is 5-carboxymethyl-N-methylindol-3-yl.
A further example of the interconversion preparation may be the preparation of a compound of formula I wherein R 1 is R 2<sup>1</sup> is an aryl group or a heteroaryl group substituted with a -SC 1 NY 4 group<sup>2</sup>:
(i) reacting a compound of formula I, wherein R 1<sup>1</sup> is aryl or heteroaryl substituted by hydroxy, with N-phenyltrifluoromethanesulfonimide as previously described;
(ii) reacting the resulting triflate with tert-butanethiol in the presence of sodium tert-butoxide, palladium acetate, lithium chloride and R - (+) - 2,2'-bis (diphenylphosphino) -1,1'-binaphthyl in an inert solvent such as is toluene, at a temperature of 110 to 120 ° C;
(iii) reacting the resultant compound of Formula I wherein R 1<sup>1 </sup>is an aryl or heteroaryl group substituted with t-BuS-, with trifluoroacetic acid and mercuric acetate in an inert solvent such as toluene, at room temperature and subsequent reaction with sulfane;
(iv) reacting the resulting compound of formula (I) wherein R 1<sup>1</sup> is aryl or heteroaryl substituted with -SH, with chlorine in aqueous acetic acid at room temperature;
(v) reacting the resultant compound of Formula I wherein R 1<sup>1</sup> is an aryl or heteroaryl group substituted with -SO 2 Cl, with an amine of the formula HNY 4<sup>2</sup>.
A further example of the interconversion preparation may be the preparation of a compound of formula I wherein R 1 is R 2<sup>1</sup> is an aryl or heteroaryl group substituted with an aryl (or heteroaryl) group, by reaction of a compound of Formula I wherein R is<sup>1</sup> is an aryl or heteroaryl group substituted with a hydroxy group, with N-phenyltrifluoromethanesulfonimide as described above and then reacting the resulting triflate here with an aryl (or heteroaryl ester) boronic acid in the presence of a suitable phenylphosphine palladium (0)] in an inert solvent (e.g. and aqueous sodium bicarbonate such as dimethylformamide, at a temperature of
120-150 ° C.
A further example of the interconversion preparation may be the preparation of a compound of formula I wherein R 1 is R 2<sup>1</sup> is an aryl or heteroaryl group substituted with a hydroxy group, by reaction of the corresponding compound of formula I, wherein R is<sup>1</sup> is an aryl or heteroaryl group substituted with a methoxy group, with a Lewis acid such as boron tribromide in an inert solvent such as dichloromethane at a temperature from 0 ° C to room temperature.
A further example of the interconversion preparation may be the preparation of a compound of formula I wherein R 1 is R 2<sup>1</sup> is aryl or heteroaryl substituted with -OR<sup>4</sup>by alkylation of the corresponding compound of formula (I) wherein R 1 is R 2<sup>1 </sup>is an aryl or heteroaryl group substituted with a hydroxy compound of formula VII <sub>R</sub>4_<sub>X</sub>3 (VII) wherein R<sup>4</sup> has already been defined and X<sup>3</sup> is a halogen atom, preferably a bromine atom, or a tosyl group, using standard alkylation conditions. For example, the alkylation may be carried out in the presence of a base such as an alkali metal carbonate (e.g. potassium carbonate or cesium carbonate), an alkali metal alkoxide (e.g. potassium tert-butoxide) or an alkali metal hydride (e.g. sodium hydride) in dimethylformamide or dimethyl sulfoxide. 0 ° C to 100 ° C.
Alternatively, the compounds of formula (I) wherein R @ 1 may be present<sup>1</sup> is aryl or heteroaryl substituted with -OR<sup>4</sup>, may be prepared by reacting the corresponding compound of formula (I) wherein R 1<sup>1</sup> is aryl or heteroaryl
170 a hydroxyl-substituted group with the corresponding alcohol of formula VIII
R<sup>4</sup>—OH (VIII) wherein R<sup>4</sup> is already defined, in the presence of a triarylphosphine such as triphenylphosphine, and a dialkylacetylenedicarboxylate such as diisopropylacetylenedicarboxylate or dimethylacetylenedicarboxylate, in an inert solvent such as toluene at room temperature. This process is particularly suitable for the preparation of compounds of formula (I) wherein R 1 is R 2<sup>1</sup> is a heteroaryl group substituted with -OR<sup>4</sup>.
A further example of the interconversion preparation may be the preparation of a compound of formula I wherein R 1 is R 2<sup>1</sup> is aryl or heteroaryl substituted with -OR<sup>4</sup>where R<sup>4</sup> is a propyl group substituted with a hydroxy group, by reaction of the corresponding compound of formula (I) wherein R 1 is R 1<sup>1</sup> is aryl or heteroaryl substituted with -OR<sup>4</sup>where R<sup>4</sup> is a propenyl group, with a borane and subsequent reaction with hydrogen peroxide in the presence of sodium hydroxide. This process is particularly suitable for the preparation of compounds of formula (I) wherein R 1 is R 2<sup>1 </sup>is an indolyl group substituted with -OCH<sub>2</sub>CH (CH<sub>3</sub>OH and -OCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>OH.
A further example of the interconversion preparation may be the preparation of a compound of formula I wherein R 1 is R 2<sup>1</sup> is aryl or heteroaryl substituted with -OR<sup>4</sup>where R<sup>4</sup> is a 1,3-dihydroxyalkylene group, by reacting the corresponding compound wherein R is an alkenyl group with osmium tetroxide in the presence of 4-methylmorpholine-N-oxide. The reaction may conveniently be carried out in an inert solvent such as acetone at room temperature.
A further example of the interconversion preparation may be the preparation of a compound of formula (Ia) wherein R 1<sup>9</sup> is alkyl, alkenyl, cycloalkyl, heterocycloalkyl or alkyl substituted with -C (= O) NY<sup>1</sup>Y<sup>2</sup>, -OR<sup>6</sup>, -C (= O) -OR<sup>7</sup>, -NY<sup>4</sup>Y<sup>2</sup>by alkylation of the corresponding compound of formula (Ia) wherein R 1<sup>9 </sup>is a hydrogen atom, corresponding to a halide of the formula (IX) ## STR6 ## wherein R @ 1<sup>9</sup> is alkyl, alkenyl, cycloalkyl, heterocycloalkyl or alkyl substituted with -C (= O) NY<sup>1</sup>Y<sup>2</sup>, -OR<sup>7</sup>, -O (= O) -OR<sup>5</sup>, -NY<sup>1</sup>Y<sup>2</sup>, and X<sup>4</sup> is a halogen atom, suitably a bromine atom,
I using standard alkylation conditions as described, for example.
As another example of the interconversion preparation, the preparation of a compound of formula I containing the group -N (R 3) may be mentioned<sup>6</sup>) -C (= O) -NY<sup>3</sup>Y<sup>4</sup>where R<sup>6</sup> and Y<sup>3</sup> are hydrogen and Y<sup>4</sup> has already been defined by reacting the corresponding compound of formula I containing an amino group with an isocyanate of formula O = C = NY<sup>4 </sup>in an inert solvent such as tetrahydrofuran at room temperature.
As another example of the interconversion preparation, the preparation of a compound of formula I containing sulfoxide linkages may be prepared by oxidation of the corresponding compound containing the -S- linkages. For example, this oxidation may conveniently be carried out by reaction with a peroxyacid, for example m-chloroperbenzoic acid, suitably in an inert solvent, for example dichloromethane, suitably at or near room temperature, or alternatively with potassium hydrogen peroxide monosulfate in a solvent. and liquid such as aqueous methanol buffered to pH 5 at 0 ° C to room temperature. This second method is advantageous for compounds containing acid labile groups.
As another example of the interconversion preparation, the preparation of a compound of Formula I containing sulfone linkages may be prepared by oxidation of the corresponding linker containing compounds.
172
-S- or sulfoxide linkages. For example, the oxidation may conveniently be carried out by reaction with a peracid, for example m-chloroperbenzoic acid, suitably in an inert solvent, for example dichloromethane, suitably at or near room temperature.
As another example of the interconversion preparation, the preparation of a compound of formula I containing a cyano group may be prepared by reacting a corresponding compound of formula I containing a group -C (= O) -NH 2 with phosphorus pentachloride in the presence of triethylamine. The reaction may conveniently be carried out in an inert solvent such as tetrahydrofuran at the boiling point of the mixture.
As another example of the interconversion preparation, the preparation of a compound of Formula I containing a tetrazolyl group may be prepared by reacting the corresponding compound of Formula I containing a cyano group with azidotributyltin. The reaction may conveniently be carried out in an inert solvent such as toluene at the boiling point of the mixture.
A further example of the interconversion preparation may be the preparation of a compound of formula I wherein R 1 is R 2<sup>2</sup> is a fluorine atom, by reaction of a corresponding compound of formula I wherein R is hydrogen with methylmagnesium bromide (in an inert solvent such as tetrahydrofuran at about 0 ° C) and a subsequent reaction with 1-chloromethyl-4-fluoro- 1,4-diazonium bicyclo [2.2.2] octane-bis (tetrafluoroborate) at 0 ° C to the boiling point of the mixture.
The compounds of the present invention may contain asymmetric centers. These asymmetric centers may be either in the R or S configuration. Those skilled in the art will recognize that some of the compounds of the present invention may also be represented by geometric isomerism. It is understood that the present invention includes the individual geometric isomers and stereoisomers and mixtures thereof, including the racemic mixtures of the compounds of Formula I described above.
173 separated by the application or adaptation of known methods, for example chromatographic techniques and recrystallization techniques, or prepared separately from the corresponding isomers of their intermediates.
In another aspect of the invention, the acid addition salts of the compounds of the present invention may be prepared by reacting the free base with a suitable acid by applying or adapting known methods. For example, the acid addition salts of the present invention may be prepared either by dissolving the free base in water or aqueous alcoholic solution or another suitable solvent containing the appropriate acid and isolating the salt by evaporating the solution, or by reacting the Free base with acid in organic solvent. Or obtained by concentrating the solution.
The acid addition salts of the compounds of the present invention can be regenerated from the salts by application or adaptation of known methods. For example, the parent compound of the present invention can be regenerated from their acid addition salts by treatment with a base, for example an aqueous sodium bicarbonate solution or an aqueous ammonia solution.
The compounds of the present invention can be regenerated from their basic addition salts by application or adaptation of known methods. For example, the parent compound of the present invention can be regenerated from their base addition salts by treatment with an acid, such as hydrochloric acid.
The compounds of the present invention may conveniently be prepared or prepared by the process of the present invention as solvates (eg hydrates). Hydrates of the compounds of the present invention can be conveniently prepared by recrystallization from an aqueous / organic solvent mixture using an organic solvent such as dioxane, tetrahydrofuran or methanol.
In another aspect of the present invention, the reaction of free acid with a suitable base can be known by application or adaptation
174 methods for preparing base addition salts of compounds of the present invention. For example, the base addition salts of the compounds of the present invention may be prepared either by dissolving the free acid in water or an aqueous alcoholic solution or another suitable solvent containing a suitable base and isolating the salt by evaporating the solution, or by reacting The free acid and base in an organic solvent. is obtained by concentrating the solution.
Starting materials and intermediates may be prepared by application or adaptation of known methods, for example methods described in Reference Examples or their apparent chemical equivalents.
Compounds of formula (IV) wherein R1<sup>1</sup> as defined above, may be prepared by reacting the corresponding compound of formula (1)
R<sup>1</sup>—CHO (<sup>1</sup>) R<sup>1</sup> has already been defined, with hydroxylamine hydrochloride in an inert solvent such as dimethylformamide at a temperature of about 150 ° C.
Compounds of formula (IV) wherein R1<sup>1</sup> is a group of formula (IIa) wherein R1<sup>10</sup> and p are already defined and R<sup>?</sup> is alkyl, alkenyl, cycloalkyl or alkyl substituted with -C (= O) NY<sup>1</sup>Y<sup>2</sup>, -OR<sup>4</sup>-C (= O) -OR<sup>7</sup>, -NY4<sup>2</sup>may be prepared by the alkylation of the corresponding ind-indole of formula IV, wherein R 1 is R 2<sup>1</sup> is a group of formula (IIa) wherein R1<sup>10</sup> and p are already defined and R<sup>9</sup> is hydrogen, with the corresponding (optionally substituted) alkyl halide, alkenyl halide or cycloalkyl halide using standard alkylation conditions. For example, the alkylation may be carried out in the presence of a base such as an alkali metal carbonate such as potassium carbonate or an alkali metal hydride such as sodium hydride in an inert solvent such as dimethylformamide or dimethyl sulfoxide at room temperature up to 100 ° C.
Compounds of formula (IV) wherein R 1<sup>1</sup> is a 5,6,7,8-tetrahydroindolizin-1-yl group, the following may be prepared:
(i) reacting piperidine-2-carboxylic acid with formic acid and acetic anhydride at room temperature;
(ii) reacting the resulting sodium 1-formylpiperidine-2-carboxylate with 4-toluenesulfonyl chloride in an inert solvent such as dichloromethane at room temperature;
(iii) reaction with acrylonitrile in the presence of triethylamine at room temperature.
Compounds of formula (1) wherein R 1<sup>1</sup> as defined above, may be prepared by formylation of a compound of formula 2
R<sup>1</sup>—H (2) wherein R<sup>1</sup> has already been defined using standard reaction conditions, for example using the Vilsmeier-Haack formylation reaction with phosphorus oxychloride in dimethylformamide. This process is particularly suitable for the preparation of compounds of formula (I) wherein R 1 is R 2<sup>1</sup> is an optionally substituted N-methylindol-3-yl group.
Compounds of formula V wherein R 1<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> have already been defined and X<sup>2</sup> is an iodine atom, may be prepared by iodination of a compound of formula 3
<img file="SK9012002A3_D0027.tif" />
where R<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> have already been defined. The iodination may conveniently be accomplished by application or adaptation of the procedure described by Saulnier and Gribble, J. Org. Chem., 47, 1982 (1982), for example by reacting a compound of formula 3 with lithium diisopropylamide in an inert solvent and a solvent such as tetrahydrofuran at -78 ° C followed by the reaction of the resulting anion with iodine. This reaction is conveniently carried out with an NH group of indole protected, for example, with a tosyl group.
Compounds of formula 3 wherein R1<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> as defined above, may be prepared by cyclization of Formula 4 compounds
<img file="SK9012002A3_D0028.tif" />
<img file="SK9012002A3_D0029.tif" />
(3) where R<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> have already been defined. The cyclization reaction may conveniently be carried out in the presence of alkali metal alkoxide such as sodium ethoxide in an inert solvent such as ethanol at room temperature to the boiling point of the mixture.
Compounds of formula 3 wherein R1<sup>3</sup> and X<sup>1</sup> have already been defined and R<sup>2</sup> is a hydrogen atom, may be prepared by cyclization of a compound of formula 5
<img file="SK9012002A3_D0030.tif" />
(4) where R<sup>3</sup> and X<sup>1</sup> have already been defined. The cyclization reaction may conveniently be carried out in the presence of sodium amide in N-methylaniline at a temperature of 120 ° C to 200 ° C.
Compounds of formula 3 wherein R1<sup>3</sup> and X<sup>1</sup> have already been defined and R<sup>2</sup> is methyl (or C 1-4 alkyl optionally substituted with -Z)<sup>X</sup>R<sup>8</sup>where Z<sup>1</sup> and R<sup>8</sup> as defined above), may be prepared by cyclizing compounds of Formula 6:
177
<img file="SK9012002A3_D0031.tif" />
<img file="SK9012002A3_D0032.tif" />
(6)
<img file="SK9012002A3_D0033.tif" />
where R<sup>3</sup> and X<sup>1</sup> have already been defined, R *<sup>1</sup> is a hydrogen atom (or an alkyl group having 1 to 3 carbon atoms optionally substituted with -Z 2)<sup>8</sup>where Z<sup>1</sup> and R<sup>3</sup> already defined) and X<sup>5</sup> is a halogen atom, suitably a bromine atom or a triflate group. The cyclization may conveniently be carried out in the presence of a complex metal catalyst such as tetrakis (triphenylphosphine) palladium (0), and tertiary amine such as triethylamine and triarylphosphine such as triphenylphosphine in an inert solvent. 60 ° C to 120 ° C. This process is particularly suitable for the preparation of compounds of formula (3) wherein R 1 is R 2<sup>3</sup> and X<sup>1</sup> have already been defined, X<sup>1 </sup>is nitrogen and R is<sup>2</sup> is C-CH<sub>3</sub>.
Compounds of formula 3 wherein R 1<sup>3</sup>, R<sup>2</sup> and X<sup>1</sup> already defined, the following may be prepared:
(i) reacting a compound of formula 7
<img file="SK9012002A3_D0034.tif" />
(7) where R<sup>3</sup> and X<sup>1</sup> have already been defined and X<sup>6</sup> is a halogen atom, preferably an iodine atom, with an acetylene of formula 8
R<sup>2</sup>-C≡C-SiMe<sub>3</sub> (8) (ii) desilylation.
where R<sup>2</sup> has already been defined, in the presence of a complex metal catalyst such as [1,1'-bis (diphenylphosphino) ferrocene] palladium chloride, lithium chloride and sodium carbonate, in an inert solvent such as dimethylformamide at a temperature of up to 100 ° C.
178
Compounds of formula 4 wherein R 1<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> as defined above, may be prepared by reacting a compound of formula 9
<img file="SK9012002A3_D0035.tif" />
(9) where R<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> have already been defined, with a mixture of formic acid and acetic anhydride.
Compounds of formula 5 wherein R 1<sup>3</sup> and X<sup>1</sup> as defined above, may be prepared by reacting the corresponding compound of formula (9), wherein R 1 is as defined above<sup>3</sup> and X<sup>1</sup> have already been defined and R<sup>2</sup> is a hydrogen atom with triethyl orthoformate in the presence of an acid catalyst such as hydrogen chloride in ethanol at room temperature to the boiling point of the mixture.
Compounds of formula (6) wherein R 1<sup>3</sup>, R<sup>11</sup> and X<sup>1</sup> have already been defined and X<sup>5</sup> is a halogen atom, may be prepared by alkylation of a compound of formula (7) wherein R 1 is a halogen atom;<sup>3</sup>, X<sup>1</sup> and X<sup>6</sup> are as defined above with a suitable alkenyl halide of formula 10
R<sup>n</sup>-CH = CH-CH<sub>2</sub> -X<sup>7</sup> (10) where R<sup>11</sup> has already been defined and X<sup>7</sup> is a halogen atom, suitably a bromine atom. The alkylation may conveniently be carried out in the presence of an alkali metal hydride such as sodium hydride in an inert solvent such as tetrahydrofuran at room temperature.
Compounds of formula (7) wherein R 1<sup>3</sup> and X<sup>1</sup> have already been defined and X<sup>6</sup> is a bromine atom, may be prepared by bromination of a compound of formula 11
<img file="SK9012002A3_D0036.tif" />
(11)
179 where R<sup>3</sup> and X<sup>1</sup> have already been defined, in dimethylsulfoxide.
Compounds of formula (7) wherein R 1<sup>3</sup> and X<sup>1</sup> have already been defined and X<sup>5</sup> is an iodine atom, may be prepared by iodination of a compound of formula 11 wherein R is<sup>3</sup> and X<sup>1</sup> have already been defined. Iodination can be accomplished by application or adaptation of the procedure of WW Sy, Synth. Comm., 22, 3215-3219 (1992).
Compounds of formula V wherein R 1<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> have already been defined and X<sup>3</sup> is a triflate group, may be prepared by reacting a compound of Formula 12
<img file="SK9012002A3_D0037.tif" />
where R<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> as defined above, with triflyl anhydride in the presence of Hunig's base in an inert solvent such as dichloromethane at a temperature of about 0 ° C. This reaction is conveniently carried out with an NH group of an indole protected, for example, with a tosyl group.
Compounds of formula 12 wherein R 1<sup>2</sup>, R<sup>3</sup> and X<sup>1</sup> as defined above, may be prepared by reacting a compound of formula 13
<td>χΐ s></td><td></td><td rowspan="2"> (13)</td>
<td><sup>r3</sup>T</td><td>7-CHO</td>
<td></td><td> \</td><td></td>
<td></td><td>H</td><td></td>
<td colspan="2">where R<sup>3</sup> and X<sup>1</sup> have already been defined, with acid</td><td>m-chloroperbenzoic acid v</td>
an inert solvent such as dichloromethane at a temperature of about 5 ° C. This reaction is conveniently carried out with an NH group of an indole protected, for example, with a tosyl group.
Compounds of formula (13) wherein R 1<sup>3</sup> and X<sup>1</sup> can be prepared by reacting a compound of formula 14 wherein R @ 1<sup>3</sup> and X<sup>1</sup> as defined above, with lithium diisopropylamide in an inert solvent such as tetrahydrofuran and subsequent reaction with dimethylformamide at a temperature of about -78 ° C. This reaction is conveniently carried out with an NH group of an indole protected, for example, with a tosyl group.
Compounds of formula (14) wherein R 1<sup>3</sup> and X<sup>1</sup> as defined above, may be prepared by reacting a compound of formula (7) wherein R 1<sup>3</sup> and X<sup>1</sup> have already been defined and X<sup>6</sup> is an iodine atom, with trimethylsilylacetylene in the presence of a complex metal catalyst such as [1,1'-bis (diphenylphosphino) ferrocene] palladium (II) chloride, followed by desilylation.
Compounds of formula (VI) wherein R 1<sup>1</sup> as defined above, may be prepared by reacting a compound of Formula 15
R<sup>1</sup>-X<sup>8</sup> where R is already defined and X<sup>8</sup> is a halogen atom, preferably a bromine atom, in the presence of tributylborate with a suitable base such as butyllithium in an inert solvent such as tetrahydrofuran at a temperature of about -100 ° C.
Compounds of formula (VI) wherein R 1<sup>1</sup> as defined above, may also be prepared by reacting a compound of formula 15, wherein R & lt; 1 & gt;<sup>1</sup> has already been defined and X<sup>8</sup> is -HgOAc, with a borane in an inert solvent such as tetrahydrofuran at room temperature.
Compounds of formula (15) wherein R 1<sup>1</sup> is optionally substituted indol-3-yl and X<sup>8</sup> is a bromine atom, may be prepared by reacting an optionally substituted indole with a bromine atom
181 an inert solvent such as dimethylformamide at room temperature.
Compounds of formula (13) wherein R 1<sup>1</sup> is an optionally substituted indol-3-yl group and X<sup>8</sup> is a -HgOAc group, may be prepared by reacting an optionally substituted indoline with mercuric acetate in glacial acetic acid at room temperature.
DETAILED DESCRIPTION OF THE INVENTION
The present invention is further illustrated, but not limited, by the following examples and reference examples.
400 MHz ^-NMR (NMR) spectra were measured on a Varian Unity INOVA instrument. In nuclear magnetic resonance (NMR) spectra, chemical shifts (δ) are expressed in ppm relative to tetramethylsilane. Abbreviations used have the following meaning: s = singlet; d = doublet; t = triplet; m = multiplet; q = quadruplet; dd = doublet of doublets; ddd = doublet of doublets of doublets.
HPLC retention times<sub>T</sub>) were measured as follows:
method A: column C 1<sub>8</sub> Phenomenex (150 x 4.6 mm), eluting with a gradient of acetonitrile / water with 0.1% trifluoroacetic acid (0 to 1 minute, 5% acetonitrile; 1 to 12 minutes, increasing to 95% acetonitrile; 12) % to 14.95 minutes, 95% acetonitrile; minute, 0% acetonitrile); or method B: YMC ODS-AQ column (2 x 50 mm) eluting with a gradient of acetonitrile / water with 0.1% formic acid [95/5 / 0.1% (A) to 5/95 / 0.1% (B)] at a flow rate of 0.4 ml / min); or Method C: elution with a gradient of a mixture of acetonitrile and water with 0.1% formic acid (95/5 / 0.1%, water / acetonitrile / formic acid,
0.1 min, linear gradient to 5/95 / 0.1%, water / acetonitrile ril / formic acid in 2 min to 3.5 min).
Thin Layer Chromatography (TLC, R<sub>F</sub>) was measured on Merck silica gel sheets.
Example 1 (a) 6- (5-Methoxy-1-methyl-ΙΗ-indol-3-yl) -5 H -pyrrolo [2,3- b] pyrazine
To a stirred solution of 59.9 mL of diisopropylamine in 1400 mL of tetrahydrofuran was added 131 mL of a 1.6 M solution of n-butyllithium in hexane over 25 minutes at -15 ° C under nitrogen, maintaining the temperature below -10 ° C. . The mixture is stirred for 30 minutes and then 26.8 g of methylpyrazine are added over 15 minutes, the mixture is stirred for 1 hour and then a solution of 53 g of 5-methoxy-1-methyl-1H-indole-3-carbonitrile is added. Example 1 (a)] in 600 mL of tetrahydrofuran while maintaining the temperature below -10 ° C. The reaction mixture was allowed to warm to room temperature over 2 hours, allowed to stand overnight, then 100 mL of water was added. The tetrahydrofuran is then removed in vacuo and the residue is partitioned between 500 ml of ethyl acetate and 200 ml of water. The layers were separated and the aqueous layer was extracted with 200 mL ethyl acetate. The combined organic layers were washed with 500 mL of water and then evaporated. The residue is purified by chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (19: 1, v / v), and. 19.4 g of the title compound is obtained as a gray solid, m.p. 270-272 ° C. Mass Spectrum: 279 (MH +);<sup>+</sup>) .
(b) Using a similar procedure to that described in Example 1 (a), but using 1-methylindi-S-carbonitrile [Reference Example 2 (b)], 6- (1-methyl-1H-indol-3-yl) was prepared. 1 H -pyrrolo [2,3- b] pyrazine as a yellow solid, mp 264-266 ° C. [Elemental analysis: C, 72.34; H, 4.68; N, 22.28%. Calculated for Ci<sub>5</sub>hi<sub>2</sub>N<sub>4</sub>: C, 72.56; H, 4.87; N, 22.57%].
(c) Following a procedure similar to that described in Example 1 (a), but using 3-bromobenzonitrile to produce 6- (3-bromophenyl) -5H-pyrrolo [2,3-b] pyrazine as a colorless solid mp 247-249 ° C. Mass Spectrum: 276 (MH +);<sup>+</sup>) .
(d) By a similar procedure to that described in Example 1 (a), but using 2-isobutylpyrazine and benzonitrile, 7-isopropyl-6-phenyl-5H-pyrrolo [2,3-b] pyrazine was prepared as a colorless solid with mp 216-218 ° C. Mass Spectrum: 238 (MH +);<sup>+</sup>) .
(e) Following a procedure similar to that described in Example 1 (a), but using 4-bromobenzonitrile, 6- (4-bromophenyl) -5H-pyrrolo [2,3-b] pyrazine was prepared as a colorless solid at temperature mp 326-329 ° C. Mass Spectrum: 276 (MH +);<sup>+</sup>) .
(f) In a similar manner to that described in Example 1 (a), but using 2- (4-cyanophenyl) -1,3-dioxane [prepared according to U.S. Patent Application Ser. 5,750,723, for example 3a] is prepared
6- [4- (1,3-dioxan-2-yl) phenyl] -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, m.p. 288-289 ° C. TLC:<sub>F</sub> = 0.34 (ethyl acetate / pentane 1: 1).
(g) In a similar manner to that described in Example 1 (a), but using 2- (3-cyanophenyl) -1,3-dioxane [prepared according to U.S. Patent Application Ser. 5,750,723, for example 3a] is prepared
6- [3- (1,3-dioxan-2-yl) phenyl] -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, m.p. 205-206 ° C. [Elemental analysis: C, 68.28; H, 5.46; N, 15.02%. Calcd. For C 16 H 15 N 3 O 2: C, 68.31; H, 5.37; N, 14.94%].
(h) Following a procedure similar to that described in Example 1 (a), but using 2-quinolinecarbonitrile, 2- (5H-pyrrolo [2,3-b] pyrazin-6-yl) quinoline was prepared as a pale yellow solid at temperature. mp 293-295 ° C. Mass Spectrum: 247 (MH +);<sup>+</sup>). [Elemental analysis: C, 72.76; H, 3.82; N, 22.56%. Calculated for
C16H15N3O2: C, 73.16; H, 4.09; N, 22.56%].
184 (i) Following a procedure similar to that described in Example 1 (a), but using 3-isoquinolinecarbonitrile, 3- (5H-pyrrolo [2,3-h] pyrazin-6-yl) isoquinoline was prepared as a green solid with mp 281-285 ° C. Mass Spectrum: 247 (MH +);<sup>+</sup>) .
(j) In a similar manner to that described in Example 1 (a), but using 1-methyl-1H-indole-5-carbonitrile [Reference Example 2 (c)], 6- [1-methyl-1H-indole- 5-yl] -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, mp 260-265 ° C. Mass Spectrum: 249 (MH +);<sup>+</sup>) .
(k) By a similar procedure to that described in Example 1 (a), but using 2,6-dimethylpyrazine, 6- (5-methoxy-1-methyl-1H-indol-3-yl) -2-methyl- 5 H -pyrrolo [2,3- b] pyrazine as a yellow solid. Mass Spectrum: 293 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ
12.2 - 12.3 (1H, broad s); 8.54, 8.56 (2x 1H, s); 7.50 (1H, d, J = 8.9Hz); 7.47 (1H, d, J = 2.4Hz); 6.96 (1H, dd, J = 8.9 and
2.4 Hz); 6.91 (1 H, s); 3.91, 3.87 and 2.57 (3 * 3H, s).
(1) In a similar manner to that described in Example 1 (a), but using 2,5-dimethylpyrazine and 1-methyl-1H-indole-3-carbonitrile [Reference Example 2 (c)], 3-methyl- 6- (1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, m.p. 170-175 ° C. Mass Spectrum: 263 (MH +);<sup>+</sup>) .
(m) In a similar manner to that described in Example 1 (a), but using 1-benzyl-5-methoxy-1H-indole-3-carbonitrile [Reference Example 2 (g)], 6- (1-benzyl- 5-methoxy-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, mp 240-244 ° C. TLC:<sub>F</sub> = 0.5 (dichloromethane / methanol 19: 1).
(n) In a similar manner to that described in Example 1 (a), but using 1-methyl-1 H -pyrrole-3-carbonitrile [Reference Example 2 (i)], 6- (1-methyl-1H) was prepared. (pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, mp 211-213 ° C.
185
Mass Spectrum: 199 (MH +);<sup>+</sup>) .
(o) In a similar manner to that described in Example 1 (a), but using 1-methyl-1 H -pyrrole-2-carbonitrile [Reference Example 2 (j)], 6- (1-methyl-1 H -pyrrole-) was prepared. 2-yl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, mp 208-209 ° C; Mass Spectrum: 199 (MH +);<sup>+</sup>) .
(p) In a similar manner to that described in Example 1 (a), but using indolizine-1-carbonitrile [Reference Example 5], 6- (indolizin-1-yl) -5H-pyrrolo [2,3- b] pyrazine as a yellow solid, m.p. 224-225 ° C (dec.). Mass Spectrum: 235 (MH +);<sup>+</sup>) .
(q) In a similar manner to that described in Example 1 (a), but using 3-methylindolizine-1-carbonitrile [Reference Example 6], 6- (3-methylindolizin-1-yl) -5E-pyrrolo [2, 3-b] pyrazine as a yellow solid, mp 233-235 ° C (dec.). Mass Spectrum: 249 (MH +);<sup>+</sup>) .
(r) In a similar manner to that described in Example 1 (a), but using 1-methyl-5-phenyl-1 H -pyrrole-3-carbonitrile [Reference Example 2 (k)], 6- (1) was prepared. methyl-5-phenyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, m.p. 221-222 ° C (dec.). Mass Spectrum: 275 (MH +)<sup>+</sup>) .
(s) In a similar manner to that described in Example 1 (a), but using 5,6,7,8-tetrahydroindolizine-1-carbonitrile [Reference Example 8], 6- (5,6,7,8-) is prepared. tetrahydroindolizin-1-yl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, mp 236-238 ° C (dec.). Mass Spectrum: 239 (MH +);<sup>+</sup>) .
(t) In a similar manner to that described in Example 1 (a), but using 3-furonitrile, 6- (fur-3-yl) -5H-pyrrolo [2,3-b] pyrazine was prepared as an orange solid. Mass Spectrum: 186.79 (MH +)<sup>+</sup>TLC: Rf = 0.45 (dichloromethane / methanol 19: 1).
186 (u) Following a procedure similar to that described in Example 1 (a), but using 4- (N, N-dimethylamino) benzonitrile, dimethyl [4- (5H-pyrrolo [2,3-b] pyrazine-6-) was prepared. yl) phenyl] amine as a yellow solid, mp 297-298 ° C. Mass Spectrum: 239 (MH +);<sup>+</sup>) .
J (v) In a similar manner to that described in Example 1 (a), but using ethylpyrazine, 6- (5-methoxy-1-methyl-1H-indol-3-yl) -7-methyl-5H-pyrrolo was prepared [2,3-b] pyrazine as a yellow solid, mp 243-244 ° C. HPLC (Method A): Rt<sub>T</sub> = 6.73 minutes.
(w) By a similar procedure to that described in Example 1 (a), but using 4-tert-butylbenzonitrile, the reaction was carried out at room temperature. Preparation of 6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid. LCMS: Rt<sub>T</sub> = 3.29 minutes; 252 (MH +)<sup>+</sup>) .
(x) In a similar manner to that described in Example 1 (a), but using 2-ethylpyrazine and 4-tert-butylbenzonitrile, 6- (4-tert-butylphenyl) -7-methyl-5H-pyrrolo [2, 3-b] pyrazine as a yellow solid, m.p. 213-214 ° C. Mass Spectrum: 266 (MH +);<sup>+</sup>) .
(y) Following a similar procedure to that described in Example 1 (a), but using 3,4-dimethoxybenzonitrile, 6- (3,4-dimethoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine was prepared as a yellow-orange color. mp 212-214 ° C. Mass Spectrum: 256 (MH +);<sup>+</sup>) .
(z) In a similar manner to that described in Example 1 (a), but using 2-ethylpyrazine and 4-aminobenzonitrile, 6- (4-aminophenyl) -7-methyl-5H-pyrrolo [2,3-b] was prepared. pyrazine as a brown solid, m.p. 330-332 ° C. Mass Spectrum: 225 (MH +);<sup>+</sup>) .
(aa) In a similar manner to that described in Example 1 (a), but using 4- (1-methyl) ethoxybenzonitrile [Reference Example 51], 6- [4- (1-methyl) ethoxyphenyl] -5H-pyrrolo was prepared. [2,3-b] pyrazine vo
187 in the form of a yellow solid. Mass Spectrum: 254 (ΜΗΓ). HPLC (Method B): Rt<sub>T</sub> = 1.64 minutes.
(ab) In a similar manner to that described in Example 1 (a), but using 1H-5-cyano-1-methyl-2-methylthioimidazole [Reference Example 52], 6- (1H-1-methyl-2-) was prepared. methylthioimidazol-5-yl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, m.p. 230 ° C. Mass Spectrum: 246 (MH +);<sup>+</sup>) .
(ac) In a similar manner to that described in Example 1 (a), but using 3-cyano-1-methyl-1H-indazole [Reference Example 56 (a)], 6- (1-methyl-1H-indazole) was prepared. -3-yl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid. Mass Spectrum: 250 (MH +), 248 (MH +). .<sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 12.5 - 12.6 (1H, broad s); 8.38 (1H, d, J = 2.4Hz); 8.24 (d, 1H, J = 7.9Hz); 8.21 (s, 1H, J = 2.4Hz); 7.76 (d, 1H, J = 8.1Hz); 7.48 (t, IH); 7.32 (t, IH); 7.29 (s, 1 H); 4.18 (s, 3H).
(ad) In a similar manner to that described in Example 1 (a), but using 3-cyano-1-methyl-4-phenyl-1H-pyrrole [Reference Example 56 (b)], 6- (1-methyl) was prepared. -4-phenyl-1H-pyrrol-3-yl) -5H-pyrrolo [2,3-b] pyrazine as a solid, m.p. 195 DEG C. (dec.). Mass Spectrum: 275 (MH +)<sup>+</sup>) .
(ae) In a similar manner to that described in Example 1 (a), but using 4-fluorobenzonitrile, 6- (4-fluorophenyl) -5H-pyrrolo [2,3-b] pyrazine was prepared as an off-white solid. <sup>X</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 12.3 (s, 1H); 8.4 (d, 1H); 8.2 (d, 1H); 8.05 (d, 1H);
2H), 7.4 (d, 2H), 7.2 (s, 1H). Mass Spectrum: 213 (MH +);<sup>+</sup>) .
(af) Following a similar procedure to that described in Example 1 (a), but using 4-methoxybenzonitrile, 6- (4-methoxyphenyl; -5H-pyrrolo [2,3-b] pyrazine) was prepared as an off-white solid at temperature. mp 244-246 ° C. Mass spectrum: 225 (MH +)<sup>+</sup>) .
(ag) In a similar manner to that described in Example 1 (a), but using 4- tert -butylbenzonitrile and 4- (pyrazinyl) -1-butene [ref. 188. Example 59], 6- (4-tert-butylphenyl) was prepared. 1-7- (Propenyl) -5H-pyrrolo [2,3-b] pyrazine as a yellow solid, m.p. 207-208 ° C. Mass Spectrum: 292 (MH +);<sup>+</sup>) .
(ah) Following a procedure similar to that described in Example 1 (a), but using 4-methylthiobenzonitrile, 6- (4-methylthiophenyl) -5H-pyrrolo [2,3-b] pyrazine was prepared as a yellow solid. weight
<td>MS: 242 (MH +)<sup>+</sup>) . <sup>X</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 12.48 (1H, s);</td><td> 8,37</td><td>(1 H,</td>
<td>with); 8.18 (1 H, s); 7.98 (2H, d, J = 7.9Hz); 7.19</td><td>(2H,</td><td>d.</td>
<td>J = 7.9 Hz); 7.11 (1 H, s); 2.52 (3 H, s).</td><td></td><td></td>
<td>(ai) In a similar manner to that described in Example 1 (a)</td><td>, but</td><td>after-</td>
using 3-methoxybenzonitrile, gave 6- (3-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine as an orange solid, mp 194-196 ° C. Mass Spectrum: 226 (MH +);<sup>+</sup>) .
(i) In a similar manner to that described in Example 1 (a), but using 1-methyl-4-cyanopyrazole [prepared according to the procedure described in Yoshida, J. Het. Chem., 32, 701 (1995)], 6- (1-methyl-1H-pyrazol-4-yl) -5H-pyrrolo [2,3-b] pyrazine was prepared as an orange solid with a melting point of 232. mp 234 ° C. Mass Spectrum: 200 (MH +);<sup>+</sup>) .
(ak) In a similar manner to that described in Example 1 (a), but using 1-methyl-3-cyano-5-phenylpyrazole [Reference Example 1 (k)], 6- (1-methyl-5-phenyl) was prepared. (1H-pyrazol-3-yl) -5H-pyrrolo [2,3-b] pyrazine as an orange solid, m.p. 222-223 ° C. HPLC: Rt<sub>T</sub> = 7.36 minutes.
(a1) In a similar manner to that described in Example 1 (a), but using 2-cyanopyridine, 6- (pyrid-2-yl) -5H-pyrrolo [2,3-b] pyrazine was prepared as yellow mp 234-235 ° C. <sup>X</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 8.71 (1H, d, J = 4.1Hz); 8.38 (1 H, s); 8.24 (1 H, s); 8.17 (1H, d, J = 8.2Hz); 7.93 (1H, t, J = 8.2Hz); 7.41 (1 H, m); 7.36 (1 H, s).
(am) Following a similar procedure to that described in Example 1 (a), but using 4-cyanopyridine, 6- (pyrid-4-yl) -5H-pyrrolo [2,3-b] pyrazine was prepared as yellow. mp 324-326 ° C. <sup>X</sup>@ 1 H-NMR .delta<sub>3</sub>)<sub>2</sub>SO]: δ 8.69 (2H, d, J = 7.1 Hz); 8.45 (1 H, s); 8.33 (1 H, s); 8.00 (2H, d, J = 7.1Hz); 7.47 (1 H, s).
Example 2 <sub>T</sub> (a) 3- [3- (5H-Pyrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -propan-1-ol
To a solution of 29 g of 6- (1- [3- (tert-butyldimethylsilanyloxy) propyl] -1H-indol-3-yl} -5H-pyrrolo [2,3-b] pyrazine [Reference Example 3 (a)] at 500 ml of tetrahydrofuran was added under a nitrogen atmosphere, 144 ml of a 1.0 M solution of tetrabutylammonium fluoride in tetrahydrofuran, and the mixture was stirred for 4 hours at room temperature and then concentrated in vacuo. Water was added to the residue to give a solid which was filtered off, washed with water and dried to give 17.5 g of the title compound as a tan solid, m.p. 220-221 ° C. Mass Spectrum: 293 (MH +);<sup>+</sup>) .
(b) By a similar procedure to that described in Example 2 (a), but using 6- {1- [3- (tert-butyldimethylsilanyloxy) propyl] -5-methoxy-1H-indol-3-yl} -5H -pyrrolo [2,3-b] pyrazine [Reference Example 3 (b)], prepared 3- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indole-1] -yl] propan-1-ol as a yellow solid, mp 225-228 ° C. Mass Spectrum: 323 (MH +);<sup>+</sup>). TLC:<sub>F</sub> = 0.16 (dichloromethane / methanol 19: 1).
(c) By a similar procedure to that described in Example 2 (a), but using 6- [1- [2- (tert-butyldimethylsilanyloxy) ethyl] -1H-indol-3-yl} -5H-pyrrolo [2,3] -b] pyrazine [Reference Example 3 (c)], 2- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -ethanol was prepared as a yellow solid mp 272-273 ° C. Mass Spectrum: 279 (MH +);<sup>+</sup>) .
(d) By a similar procedure to that described in Example 2 (a), but using 6- {1- [2- (tert-butyldimethylsilanyloxy) ethyl] -5-methoxy-1H-in-190-dol-3-yl} -5) 1-pyrrolo [2,3-b] pyrazine [Reference Example 3 (d)], 2- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indole] was prepared. 1-yl-ethanol in the form of a gray solid, m.p. 270-273 ° C. Mass Spectrum: 309.43 (MH +)<sup>+</sup>) .
Example 3, (a) 3- [3- (5H-Pyrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propylamine
To a solution of 12 g of 3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propan-1-ol [Example 2 (a)] and 19.1 g of bromide of carbon dioxide in 300 ml of dichloromethane is added a solution of 12.9 g of triphenylphosphine in 100 ml of dichloromethane over 5 minutes at room temperature. The mixture was stirred for 3 hours at room temperature, the reaction mixture was filtered and the solid was washed with small portions of dichloromethane. The filtrate was evaporated to give a brown glue which was mixed with 80 ml of liquid ammonia in a sealed pressure vessel and stirred for 18 hours at room temperature. The vessel was then cooled to -78 ° C and then gently aerated. The ammonia was evaporated and the residue was purified by silica gel chromatography eluting with dichloromethane / methanol and concentrated ammonia (900: 100: 7, v / v) to give the title compound as a yellow solid (3 g). mp 170 ° C. <sup>1</sup>1 H-NMR [(CD<sub>3</sub>) 2SO]: δ 8.28 (1 H, d,
<td>J =</td><td>2.7 Hz);</td><td> 8,18</td><td>(1 H, s); 8.10.</td><td> 7,64</td><td>(2 x 1 H, d, J</td><td> -</td><td>7.7 Hz);</td>
<td> 8,09</td><td>(1 H, d,</td><td>J =</td><td>2.7 Hz); 7.29.</td><td> 7,23</td><td>(2 x 1 H, td,</td><td>J</td><td>= 7.1 and</td>
<td> 1,0</td><td>Hz); 6.97</td><td>(1 H,</td><td>with); 4.32 (2H,</td><td>t, J</td><td>= 7.0 Hz); 2</td><td> 57</td><td>(2H, t,</td>
J = 6.5 Hz); 1.89 (2H, quintet, J = 6.4 Hz).
(b) By a similar procedure to that described in Example 3 (a), but using 3- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propan-1-ol [Example 2 (b)], 3- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propylamine was prepared in the form of yellow solid, m.p. 95-100 ° C and 150-160 ° C. Mass Spectrum: 322 (MH +);<sup>+</sup>). Thin layer chromatography:
R<sub>F</sub> = 0,2 (dichloromethane / methanol / concentrated ammonia:
191
900 : 100: 7, volume).
Example 4
N- (3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-l-yl] propyl} acetamide
To a solution of 100 mg of 3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -propylamine [Example 3 (a)] was added dropwise at room temperature and under nitrogen atmosphere. 31 μΐ of acetyl chloride a
52,2 μΐ of triethylamine and 20 ml of dichloromethane. The mixture was stirred at room temperature for 24 hours and then evaporated. The residue was purified by silica gel chromatography eluting with dichloromethane / methanol (9: 1, v / v) to give 82 mg of the title compound as a yellow solid, mp 260 ° C. Mass Spectrum: 334 (MH +)<sup>T</sup>) .
Example 5 (a) 6- {1- [3- (Morpholin-4-yl) propyl] -1H-indol-3-yl} -5H-pyrrolo-
- [2,3-b] pyrazine
A mixture of 250 mg of 3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -propylbromide [Reference Example 4], 0.5 ml of morpholine, 100 mg of potassium carbonate and two The potassium iodide crystals are heated to boiling point in ethyl methyl ketone for 2 hours. The mixture was then allowed to cool to room temperature over 16 hours and then evaporated. The residue was purified by silica gel chromatography eluting with dichloromethane / methanol (9: 1, v / v) to give a yellow glass which was overlaid with ethyl acetate and pentane to give 40 mg of the title compound as a yellow solid mp 180-185 ° C. Mass Spectrum: 362 (MH +);<sup>+</sup>) .
(b) Using a similar procedure to that described in Example 5 (a), but using piperidine, 6- {1- [3- (piperidin-1-yl) propyl] -1H-indol-3-yl) -5- was prepared. -pyrrolo [2,3-b] pyrazine as a yellow solid, m.p. 240 ° C. Mass Spectrum: 360 (MH +)<sup>+</sup>) .
192
Example 6
6- (1- (3- (Pyridin-3-yloxy) propyl] -lH-indol-3-yl} -5H-pyrrolo [2,3-b] pyrazine
To a solution of 359 mg of triphenylphosphine in 2.5 mL of tetrahydrofuran at 0 ° C under nitrogen atmosphere was added dropwise a solution of 269 μΐ of diisopropyl azodicarboxylate in 0.5 mL of tetrahydrofuran dropwise over 2 minutes. The mixture is stirred for 20 minutes at the same temperature and then a solution of 65 mg of 3-hydroxypyridine in 1 ml of tetrahydrofuran is added over 1 minute, followed by a suspension of 200 mg of 3- [3- (5H-pyrrolo [2,3-b] pyrazine-). 6-yl) indol-1-yl] propan-1-ol [Example 2 (a)] in 2 mL tetrahydrofuran. The mixture was allowed to warm to room temperature over 18 hours and then evaporated. The residue was purified by silica gel chromatography eluting with ethyl acetate / methanol (9: 1, v / v) to give 110 mg of the title compound as a yellow solid, mp 208-209 ° C. Mass Spectrum: 370 (MH +);<sup>T</sup>) .
Example 7 1-Methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-ol
A mixture of 200 mg of 6- (5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine [Example 1 (a)], 500 μΐ of 48% acid of hydrobromic acid and 3 ml of glacial acetic acid are heated at reflux for 14 hours. After cooling, the mixture was neutralized by addition of saturated sodium bicarbonate solution, the resulting dark solid collected by filtration and then dried to give 180 mg of the title compound as a black solid, mp 289-290 ° C. Mass Spectrum: 264 (MH +);<sup>+</sup>) .
Example 8
6- (2-Chloro-5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine
193
To a solution of 100 mg of 6- (5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine [Example 1 (a)] in 25 ml of dimethoxyethanol cooled to -78 ° C was added 172 of lithium in hexane. The mixture was stirred while the luenesulfonyl chloride was added, and then slowly the room was evaporated and the silica gel was evaporated while the ΐ 2.5 M n-bu solution was stirred for 82 minutes with 82 mg of 4-tetrachloride temperature.
The residue was purified by chromatography eluting with dichloromethane / methanol 45 mg of the title compound Mass spectrum: 313 (MH +)<sup>+</sup>) .
and was obtained (19: 1, v / v) as a black solid.
12.20 (1 H, d, J = 3 Hz);
8,21 d,
Hz); 6.96 (1 H,
3.82 (3 H, s); 3.81 (3H, s).
Example 9 (a) 3- (5H-Pyrolo [2,3-b] pyrazin-6-yl) benzaldehyde
To a solution of 1.6 g of 6- [3- (1,3-dioxan-2-yl) phenyl] -5H-pyrrolo [2,3-b] pyrazine [Example 1 (g)] in 50 ml of dichloromethane is added ml of trifluoroacetic acid. The resulting mixture was heated at reflux for hours, then allowed to cool overnight and evaporated. The residue was overlaid with diethyl ether to give a yellow solid which was recrystallized from ethyl acetate to give 0.6 g of the title compound as a yellow crystalline solid, mp 268-270 ° C. [Elemental analysis: C, 69.96; H, 3.92; N, 18.69%. Calcd. For C 13 H 9 N 3 O: C,
69.95; H, 4.06; N, 18.82%].
(b) By a similar procedure to that described in Example 9 (a), but using 6- [4- (1,3-dioxan-2-yl) phenyl] -5,7-pyrrolo [2,3-b] pyrazine [Example 1 (f)], 4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -benzaldehyde hydrate was prepared as a yellow solid, m.p. & gt; 295 ° C. [Elemental analysis: C, 67.57; H, 4.33; N, 18.04%.
Calcd. For C 13 H 9 N 3 O. H<sub>2</sub>O: C, 67.23; H, 4.34; N, 18.09%].
194
Example 10 (a) [3- (5H-Pyrolo [2,3-b] pyrazin-6-yl) -phenyl] -methanol
To a suspension of 0.4 g of 3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) benzaldehyde [Example 9 (a)] in 50 ml of ethanol is added 200 mg of sodium borohydride and the mixture is stirred for 1 hour at room temperature, then 10 ml of water are added and the mixture is evaporated. The solid residue is covered with 50 mL of water to give a light yellow solid which is washed with water and then recrystallized from methanol to give 0.35 g of the title compound as a yellow crystalline solid, mp 225-226 ° C. . [Elemental analysis: C, 68.72; H, 4.73; N, 18.44%. Calcd. For C 13 H 11 N 3 O: C, 69.32; H, 4.92; N, 18.65%].
(b) By a similar procedure to that described in Example 10 (a), but using 4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) benzaldehyde [Example 9 (b)], [ 4- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenyl] -methanol as a yellow solid, m.p. 284-285 ° C. [Elemental analysis: C, 68.61; H, 4.65; N, 18.28. Calcd. For C 13 H 11 N 3 O: C, 69.32; H, 4.92; N, 18.65%].
Example 11
6- (5-Methoxy-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine
To a solution of 50 mg of 6- (1-benzyl-5-methoxy-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine [Example 1 (m)] in 20 ml of tetrahydrofuran cooled to 20 ml of liquid ammonia and then 100 mg of sodium are added at -78 ° C. The mixture was stirred for 30 minutes at -78 ° C, then slowly warmed to room temperature, 50 mL of water was added and the mixture was extracted three times with 50 mL of ethyl acetate. The combined extracts were dried over sodium sulfate and then evaporated. The residue was overlaid with diethyl ether to give 14 mg of the title compound as a brown solid, mp 268-271 ° C. Mass Spectrum: 265.24 (MH +)<sup>+</sup>) .
195
Example 12
2- [5-Methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -
1- (morpholin-4-yl) -ethanone
To a stirred solution of 70 mg of 6- (5-methoxy-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine [Example 11] in 10 mL of dry dimethylformamide was added 21.6 mg of hydride. sodium (60% dispersion in mineral oil). The mixture was stirred for 30 minutes and then a solution of 44.1 mg of 4- (2-chloroacetyl) morpholine in 1 ml of DMF a was added. stirring was continued for a further 3 hours. The reaction mixture is poured into 20 ml of water and then extracted three times with 30 ml of ethyl acetate. The combined extracts were dried over sodium sulfate and then evaporated. The residue was overlaid with diethyl ether to give 55 mg of the title compound as a yellow solid, mp 263-267 ° C. Mass Spectrum: 392.21 (MH +)<sup>+</sup>) .
Example 13 (a) [5-Methoxy-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -indol-1-yl] -acetic acid
A mixture of 4.67 g of {5-methoxy-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridin-2-yl] indol-1-yl} acetic acid ethyl ester [reference Example 13 (a)], 250 ml of methanol and 25 ml of 5 M aqueous potassium hydroxide are heated to boiling. The methanol is removed under reduced pressure and 20 ml of water are added to the residue and the pH of this solution is adjusted to 7 by addition of concentrated hydrochloric acid. The resulting yellow solid was collected by filtration and purified by silica gel chromatography eluting with ethyl acetate / methanol (7: 3, v / v) to give 1.69 g of the title compound as a white solid. Mass Spectrum: 320 (MH +);<sup>+</sup> ). HPLC (Method A): Rt<sub>T</sub> = 6.67 minutes.
(b) By a similar procedure to that described in Example 13 (a), but using 4-methoxy-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) 1H-pyrrolo [2,3-b] pyridine [Reference Example 2 (1)] sa
196 Preparation of 4-methoxy-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine as a yellow-brown solid, mp 288-289 ° C. Mass Spectrum: 307 (MH +);<sup>+</sup>) .
(c) By a similar procedure to that described in Example 13 (a) but using 4-methoxy-2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3-b] pyridine (Reference Example 39) was prepared
4-methoxy-2- (5-methoxy-ΙΗ-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine as a tan solid, mp 294-295 ° C. Mass Spectrum: 294 (MH +);<sup>+</sup>) .
(d) By a similar procedure to that described in Example 13 (a) but using 4-chloro-2- (4-tert-butylphenyl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] of pyridine [Reference Example 12 (j)] was prepared
4-Chloro-2- (4-tert-butylphenyl) -1H-pyrrolo [2,3-b] pyridine as a cream colored solid. Thin layer chromatography:
<td>R<sub>I '</sub> = 0,71</td><td>(ethyl acetate / heptane 1</td><td> ; 1). <sup>X</sup>H-NMR</td><td>[(CD<sub>3</sub>)<sub>2</sub>SOJ: δ 12.52</td>
<td>(1 H, s);</td><td>8.16 (1H, d, J = 6.1)</td><td>Hz); 7.93 (</td><td>2H, d, J = 8.1 Hz);</td>
<td>7.50 (2 H,</td><td>d, J = 8.1 Hz); 7.21</td><td>(1 H, d, J =</td><td>= 6.1 Hz); 6.96 (1 H,</td>
<td>with); 1,30 (</td><td>: 9H, s).</td><td></td><td></td>
<td colspan="2">(e) By a procedure similar to that</td><td>describes in</td><td>Example 13 (a) but</td>
<td>using the</td><td>2- (5-methoxy-l-methyl-lH</td><td>indol-3-yl) -</td><td>5-phenyl-l- (toluene-4-</td>
sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 13 (j)] was prepared 2- (5-methoxy-1-methyl-1H-indol-3-yl) -5-phenyl-1H -pyrrolo [2,3-b] pyridine as a cream colored solid, m.p. 240-242 ° C. Mass Spectrum: 354 (MH +).
Example 14 (a) 2- [5-Methoxy-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -indol-1-yl] -
1- (morpholin-4-yl) -ethanone
To a suspension of 60 mg of [5-methoxy-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -indol-1-yl] -acetic acid [Example 13 (a)] in 7 ml of dry dimethylformamide was added. 71 mg of N- {(dimethylamino) (1H-1,2,3-triazolo [4,5-b] pyrid-1-yl) methylene} -N-methylmethanammonium hexafluorophosphate-N-oxide and 45 μΐ of diisopropylethylamine are added. The mixture is stirred for 30 minutes at room temperature, then 18 μΐ of morpholine is added and the mixture is stirred at room temperature for a further 12 hours. The solvent was removed in vacuo and the residue was suspended in saturated sodium bicarbonate solution. The resulting precipitate was collected by filtration and dried to give 10 mg of the title compound as a violet solid, mp 243-247 ° C. Mass Spectrum: 391 (MH +)<sup>+</sup>) .
(b) In a similar manner to that described in Example 14 (a), but using 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole- 5-yloxy] cyclobutanecarboxylic acid [Example 15 (c)] and ammonium chloride, 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H- indol-5-yloxy] cyclobutanecarboxylic acid as a light violet solid, m.p. 267-268 ° C. Mass Spectrum: 361 (MH +);<sup>+</sup>) .
(c) In a similar manner to that described in Example 14 (a), but using 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole- 5-yloxy] cyclobutanecarboxylic acid [Example 15 (c)] and methylamine, 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole acid methylamide was prepared -5-yloxy] cyclobutanecarboxylic acid as a light violet solid, m.p. 2.49-250 ° C. Mass Spectrum: 375 (MH +);<sup>+</sup>) .
(d) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-in-
1-Methyl-3- (1H-pyrrolo [2,3-b] pyridin-2-yl) -1H-indole-5- (5-carboxylic acid) [Example 15 (d)] and methylamine carboxylic acid as a light orange solid, m.p. 186 ° C. Mass Spectrum: 304 (MH +);<sup>+</sup>) .
(e) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [Example 15 (d)] and ethanolamine, 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -amide (2-hydroxyethyl) amide was prepared.
198
1 H -indole-5-carboxylic acid as a yellow solid, mp 256-257 ° C. Mass Spectrum: 335 (MH +);<sup>+</sup>) .
(f) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1 H -pyrrolo [2,3- b] pyrid-2-yl) -1 H -indole-5-carboxylic acid [Example 15 (d)] and 2-aminoethylmorpholine, 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) [2- (morpholin-4-yl) ethyl] amide was prepared 1H-indole-5-carboxylic acid as a colorless solid, m.p. 268-270 ° C. Mass Spectrum: 404 (MH +);<sup>+</sup>) .
(g) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [Example 15 (d)] and β-alaninamide, 1-methyl-3- (Ιϋ-pyrrolo [2,3-b] pyrid-2-yl) -1 H -indole-5 (2-carbamoylethyl) amide was prepared. -carboxylic acid as a colorless solid, m.p. 286-288 ° C. Mass Spectrum: 362 (MH +);<sup>+</sup>) .
(h) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole
-5-carboxylic acid [Example 15 (d)] rid-2-yl) -1H-indole-5-carboxylic acid bis (2-hydroxyethyl) amide and diethanolamine, 1-methyl-3- (ΙΗ-pyrrolo [2 3-b] in the form of a yellow solid, m.p. 230 DEG-232 DEG C. Mass spectrum: 379 (MH @ +).<sup>+</sup>) .
(i) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [Example 15 (d)] and ammonium chloride, 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid amide is prepared as a yellow solid mp 330-322 ° C. Mass Spectrum: 291 (MH +);<sup>+</sup>) .
(j) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [Example 15 (d)] and tris (hydroxymethyl) aminomethane, acid [2-hydroxy-1,1-bis (hydroxymethyl) ethyl] amide is prepared
199 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid as a yellow solid, mp 205-206 ° C. Mass Spectrum: 395 (MH +)<sup>+</sup>) .
(k) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [Example 15 (d)] and 2-amino-2-methyl-1,3-propanediol, 1-methyl-3- (1H-pyrrolo [2-hydroxy-1-hydroxymethyl-1-methylethyl) amide was prepared. 2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid as a yellow solid, m.p. 180-182 ° C. Mass Spectrum: MH + = 379;<sup>+</sup>) .
(1) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [Example 15 (d)] and 3-amino-1,2-propanediol, 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-) - (2,3-dihydroxypropyl) -amide was prepared yl) -1H-indole-5-carboxylic acid as a yellow solid, mp 171-172 ° C. Mass Spectrum: 365 (MH +);<sup>+</sup>) .
(m) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [Example 15 (d)] and 2-amino-2-methyl-1-propanol, 1-methyl-3- (1H-pyrrolo [2,3- a] - (2-hydroxy-1,1-dimethylethyl) amide was prepared. b] pyrid-2-yl) -1H-indole-5-carboxylic acid yellow solid, mp 161-162 ° C.
in shape
Mass Spectrum: 365 (MH +);<sup>+</sup>) .
(n) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1-indole-5-carboxylic acid [Example 15 (d)] and serinol, 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-2-hydroxy-1-hydroxy-methylethyl-amide was prepared -indole-5-carboxylic acid as a yellow solid, m.p. 178-179 ° C. Mass Spectrum: 365.41 (MH +)<sup>+</sup>) .
200 (o) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid [Example 15 (g)] and 3-aminopropionamide hydrochloride, 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole- (2-carbamoylethyl) amide was prepared. 6-carboxylic acid as a light yellow solid, m.p. 277-280 ° C. Mass Spectrum: 362 (MH +);<sup>+</sup>) .
(p) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid [Example 15 (g)] and ethanolamine, 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid (2-hydroxyethyl) amide was prepared as a brown solid, mp 264-267 ° C. Mass Spectrum: 335 (MH +);<sup>+</sup>).
(q) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid [Example 15 (g)] and 1H- (1,2,4-triazol-3-yl) amine, 1-methyl-3 1H- (1,2,4-triazol-3-yl) amide was prepared. - (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid as a yellow solid, m.p. 343-345 ° C. Mass Spectrum: 358 (MH +);<sup>T</sup>) .
(r) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-6-carboxylic acid [Example 15 (g)] and serinol, 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole (2-hydroxy-1-hydroxymethylethyl) amide was prepared -6-carboxylic acid as a light brown solid, m.p. 247-249 ° C. Mass Spectrum: 365 (MH +);<sup>+</sup>) .
(s) In a similar manner to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid [Example 15 (i)] and 2-amino-2-methyl-1-propanol, 1-methyl-3- (5H-pyrrolo [2,3-d] [2,3-d] pyrrolidine-2-hydroxy-1,1-dimethylethyl) -amide was prepared. -b] pyrazin-6-yl) -1H-indole-5-carboxylic acid;
201 210 DEG-214 DEG. Mass Spectrum: 364 (MH +);<sup>+</sup>) .
(t) By a similar procedure to that described in Example 14 (a), but using 3- [6- (4-tert-butylphenyl-5 H -pyrrolo [2,3- b] pyrazin-7-yl] propionic acid [ Example 25 (a)] and methylamine, 3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] -N-methylpropionamide was prepared as an off-white solid at temperature mp 222-228 ° C. Mass spectrum: 337 (MH +)<sup>+</sup>) .
(u) By a similar procedure to that described in Example 14 (a), but using 3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) propionic acid [Example 25 (a)] and dimethylamine, 3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] -N, N-dimethylpropionamide is prepared as an off-white solid with mp 203-204 DEG C. Mass spectrum: 351 (MH @ +)<sup>T</sup>) .
(v) In a similar manner to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5 -carboxylic acid [Example 15 (i)] and 2-methoxyethylamine, 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5- 2-methoxyethylamide was prepared. carboxylic acid as an orange solid. Mass Spectrum: 350 (MH +);<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 1.27 minutes.
(w) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid [Example 15 (i)] and 2- (thien-2-yl) ethylamine, 1-methyl-3- (5H-pyrrolo [2,3-b] 2- (thien-2-yl) ethylamide was prepared pyrazin-6-yl) -1 H -indole-5-carboxylic acid as a yellow solid. Mass Spectrum: 402 (MH +);<sup>+</sup>). HPLC (method C):
R<sub>T</sub> = 1.45 minutes.
(x) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5- carboxylic acid [Example 15 (i)] and 2-fluoroethylamine, 1-methyl-3- (5H-pyrrolo [2,3-b] pyra) 2-fluoroethylamide was prepared
202 zin-6-yl) -1H-indole-5-carboxylic acid as an orange solid. Mass Spectrum: 338 (MH +);<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 1.30 minutes.
(y) In a similar manner to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid [Example 15 (i)] and alanine ethyl ester hydrochloride, 2- (ethoxycarbonyl) ethylamide 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5 is prepared -carboxylic acid in the form of an orange solid. Mass Spectrum: 392 (MH +);<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 1.38 minutes.
(z) In a similar manner to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid [Example 15 (i)] and Serine methyl ester hydrochloride, 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5- hydroxymethyl (methoxycarbonyl) methylamide is prepared. carboxylic acid as an orange solid. Mass Spectrum: 394 (MH +)<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 1.24 minutes.
(aa) In a similar manner to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5- carboxylic acid [Example 15 (i)] and ethanolamine, 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 2-hydroxyethylamide is prepared in the form of 171 DEG-173 DEG C. (decomposition). Mass Spectrum: 336 (MH +);<sup>+</sup>) .
(ab) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid [Example 15 (i)] and methylamine, 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid methylamide is prepared as a beige solid . Mass Spectrum: 304 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR: δ 8.64 (1H, broad s); 8.59 (d, 1H, J = 1.0Hz); 8.27 (d, 1H, J = 2.4Hz); 8.17 (s, 1 H); 8.15 (d, 1H, J = 2.4Hz); 7.82 (dd, 1H, J = 1.0 and 7.9 Hz); 7.62 (d, 1 H,
203
J = 7.9 Hz); 7.21 (s, 1 H); 3.96 (s, 3H); 2.82 (s, 3H).
(ac) In a similar manner to that described in Example 14 (a), but using 1-methyl-3- (5/7-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5 of carboxylic acid [Example 15 (i)] and dimethylamine, 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid dimethylamide is prepared in the form of yellow solid. Mass Spectrum: 320 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR: δ 8.26 (d, 1H, J = 2.1 Hz);
8.18 (s, 1 H); 8.15 (d, 1H, J = 2.1Hz); 7.62 (d, J = 8.1 Hz); 7.37 (dd, 1H, J = 1.0 and 8.1 Hz); 6.98 (s, IH); 3.94 (s, 3H); 3.05 (s, 6H).
(ad) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (5,7-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5 -carboxylic acid [Example 15 (i)] and morpholine, [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yl] morpholin-4 was prepared -ylketone in the form of a yellow solid. Mass Spectrum: 362 (MH +);<sup>+</sup>) .
(ae) In a similar manner to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5 carboxylic acid [Example 15 (i)] and 4-hydroxypiperiain, 4-hydroxy- [1- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H- indol-5-yl] carbonylpiperidine as a yellow solid. Mass Spectrum: MH + = 376;<sup>+</sup>), 398 (MNa<sup>+</sup>) .
(af) By a similar procedure to that described in Example 14 (a), but using 3- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole- 5-yl] carbonylaminopropionic acid [Example 15 (1)] and methylamine, 3- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole acid methylamide was prepared -5-yl] carbonylaminopropionic acid as a yellow solid. Mass Spectrum: 377 (MH +);<sup>+</sup>). HPLC (method
C): R<sub>T</sub> = 1.20 minutes.
(ag) By a similar procedure to that described in Example 14 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid [Example 15 (i)] and 3-hydroxypropylamine, sa
204 Preparation of 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid 3-hydroxypropylamide as a yellow solid. Mass Spectrum: 350 (MH +);<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 1.22 minutes.
(ah) By a similar procedure to that described in Example 14 (a), but using 3- {6- [4- (1-methyl) ethoxyphenyl] -5 H -pyrrolo [2,3- b] pyrazin-7-yl of [propionic [Example 25 (b)] and methylamine, 3- {6- [4- (1-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl [propionic acid] methylamide is prepared in the form of a yellow solid. Mass Spectrum: 339 (MH +)<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 1.49 minutes.
(ai) In a similar manner to Example 14 (a), but using -7-yl] propionic acid -yl] propionic acid amide is described in
3- [6- (4-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine [Example 25 (d)] and methylamine, prepared by 3- [6- (4-methoxyphenyl) -5H-pyrrolo [2] , 3-b] pyrazin-7látky.
in the form of off-white solid ^ -NMR:
(d, (d,
2H),
7.1 (d, 2H), 3.8 (s, 3H), 3.05 (t, 2H), 2.6 Mass Spectrum: 310 (MH +)<sup>+</sup>) .
(T,
2H) 2.5 (s, (i) By a similar procedure to that described in Example 14 (a), but using 3- {6- [4- (1-methyl) ethoxyphenyl] -5H-pyrrolo [2,3] -b] pyrazin-7-yl [propionic [Reference Example 25 (b)] and ammonium chloride, 3- {6- [4- (1-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] Pyrazin-7-yl [propionamide as a white solid, MS: 325 (MH +)<sup>+</sup>). HPLC (Method C): R t = 1.44 min.
(ak) By a similar procedure to that described in Example 14 (a), but using 3- {6- (4-hydroxyphenyl) -5 H -pyrrolo [2,3- b] pyrazin-7-yl [propionic [Example 30] and ammonium chloride, are prepared?
3- (6- (4-Hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl [propionamide] as a white solid Mass spectrum: 283 (MH +)<sup>+</sup>). HPLC (Method C): R t = 2.18 minutes.
(a1) In a similar manner to that described in Example 14 (a), but using 3- [6- (4-fluorophenyl) -5H-pyrrolo [2,3-b] pyrazine-7205 acid
-yl] propionic acid [Example 25 (c)] and methylamine, 3- [6- (4-fluorophenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid methylamide is prepared as off-white solid. @ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ
12.5 (s, 1H); 8.4 (d, 1H); 8.2 (d, 1H); 7.8 (d, 2H); 7.4 (d, 2H);
3.1 (t, 2H); 2.6 (t, 2H); 2.5 (s, 3H). Mass Spectrum: 298 (MH +);<sup>+</sup>) .
Example 15 (a) [1-Methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] acetic acid
To a solution of 500 mg of {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1-indol-5-yloxy} ethyl ester Acetic acid (Reference Example 15 (b)) in 25 ml of methanol is added 3 ml of a 5 M potassium hydroxide solution and the mixture is then heated at reflux for 16 hours. The solvent was removed under reduced pressure and 10 ml of water was added to the residue. The pH of this mixture was adjusted to 7 by addition of acetic acid and the resulting colorless solid was collected by filtration and then dried to give 170 mg of the title compound as a colorless solid, m.p. & gt; 300 ° C. Mass Spectrum: 322 (MH +);<sup>+</sup>) .
(b) In a similar manner to that described in Example 15 (a), but using 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] ethyl ester pyrid-2-yl] -1H-indol-5-yloxy} propionic acid (Reference Example 15 (c)), 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridine) was prepared. 2-yl) -1H-indol-5-yloxy] propionic acid as a colorless solid, m.p. 177-178 ° C. Mass Spectrum: 336 (MH +);<sup>+</sup>) .
(c) By a similar procedure to that described in Example 15 (a), but using 1- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] ethyl ester pyrid-2-yl] -1H-indol-5-yloxy} cyclobutanecarboxylic acid [Reference Example 15 (d)], acid is prepared
1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid2-yl) -1H-indol-5-yloxy] cyclobulo
206 m.p. 168-169 ° C. Mass Spectrum: 362 (MH +);<sup>+</sup>) .
(d) By a similar procedure to that described in Example 15 (a), but using 1-methyl-3- [1- (toluene-4-sulfonyl) -4-pyrrolo [2,3-b] pyrid-2-methyl ester. 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indole-5-carboxylic acid [Reference, Example 19 (a)] -indole-5-carboxylic acid as a yellow solid, m.p. & gt; 300 ° C. Mass Spectrum: 291 (MH +);<sup>+</sup>) .
(e) In a similar manner to that described in Example 15 (a), but using 1-methyl-3- [1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3- b] pyrid-2-yl 1 H -indol-5-ol [Reference Example 14 (a)], 1-methyl-3- (1 H -pyrrolo [2,3- b] pyrid-2-yl) -1 H -indole- 5-ol as a yellow solid, m.p. 199-200 ° C. Mass Spectrum: 264 (MH +);<sup>+</sup>) .
(f) By a similar procedure to that described in Example 15 (a), but using 1- {1- (ethylcyclobutanecarboxylate) -3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-a] ethyl ester b] pyrid-2-yl] -1H-indol-5-yloxy} cyclobutanecarboxylic acid [Reference Example 23 (d)], prepare 1- {1- (cyclobutanecarboxylic acid) -3- [1H-pyrrolo [2, 1, 2, 3, 3, 4, 3, 4, 3, 4, 3, 4 and 3]]. 3-b] pyrid-2-yl] -1H-indol-5-yloxy} cyclobutanecarboxylic acid as a yellow solid, mp 240 ° C (dec.). Mass spectrum: 444 (MH).
(g) By a similar procedure to that described in Example 15 (a), but using 1-methyl-3- [1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3- b] pyridine methyl ester -2-yl] -1 H -indole-6-carboxylic acid [Reference Example 13 (g)]: 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H is prepared -indole-6-carboxylic acid as a yellow solid, m.p. 359-361 ° C. Mass Spectrum: 292 (MH +);<sup>+</sup>) .
(h) By a similar procedure to that described in Example 15 (a), but using 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] ethyl ester pyrid-2-yl] -1H-indol-5-yl} propionic acid
207 [Reference Example 38 (a)], 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yl] propionic acid was prepared in m.p. 268-270 ° C. Mass Spectrum: 320 (MH +);<sup>+</sup>) .
(i) In a similar manner to that described in Example 15 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5- methyl ester carboxylic acid [Reference Example 19 (b)], 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indole-5-carboxylic acid is prepared as a brown solid with mp 350 ° C. HPLC (Method A): Rt<sub>T</sub> = 5.85 minutes.
(j) In a similar manner to that described in Example 15 (a), but using [2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenoxy] -acetic acid ethyl ester [Example 27], [2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenoxy] -acetic acid was prepared as a white solid, mp 330-322 ° C. Mass Spectrum: 300 (MH +);<sup>+</sup>) .
(k) By a similar procedure to that described in Example 15 (a), but using 3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] propionic acid ethyl ester [ Reference Example 38 (b)], 3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenyl] -propionic acid was prepared as an orange solid, m.p. 271 ° C. Mass Spectrum: 311 (MH +);<sup>+</sup>) .
(1) By a similar procedure to that described in Example 15 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-2- (ethoxycarbonyl) ethylamide of indole-5-carboxylic acid [Example 14 (y)] and sodium hydroxide, 35 mg of 3- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H] was prepared -indol-5-yl] carbonylaminopropionic acid as an orange solid. Mass Spectrum: 364 (MH +);<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 1.24 minutes.
208
Example 16 (a) 2- [1-Methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] ethanol
To a solution of 120 mg of {1-methyl-3- [1- (toluenesulfonyl) -1-H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-5 ethyl ester -yloxy} acetic acid (Reference Example 15 (b)) in 5 ml of dry tetrahydrofuran is added at 0 ° C under a nitrogen atmosphere of 50 μΐ of a 1.0 M solution of 11-aluminum aluminum hydride in tetrahydrofuran. The mixture was allowed to warm to room temperature, then stirred for 3 hours and then poured carefully into 75 ml of water. The mixture is extracted three times with 25 ml of ethyl acetate and the combined organic extracts are washed with 75 ml of saturated sodium chloride solution, then dried over sodium sulfate and then evaporated to give 45 mg of the title compound as a colorless solid, m.p. C. Mass Spectrum: 308 (MH +);<sup>+</sup>) .
(b) In a similar manner to that described in Example 16 (a), but using 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] ethyl ester pyrid-2-yl] -1 H -indol-5-yloxy [propionic [Reference Example 15 (c)], prepared 3- [1-methyl-3- (1H-pyrrolo [2,3-b]] pyrid-2-yl) -1H-indol-5-yloxy] propan-1-ol as a colorless solid, m.p. 164-165 ° C. Mass Spectrum: 320 (MH +);<sup>+</sup>) .
(c) In a similar manner to that described in Example 16 (a), but using 1- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] ethyl ester pyridin-2-yl] -1H-indol-5-yloxy} cyclobutanecarboxylic acid [Reference Example 15 (d)], prepare {1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridine)] - 2-yl) -1H-indol-5-yloxy] cyclobutyl [methanol as a colorless solid, mp 144-146 ° C. Mass Spectrum: 348 (MH +);<sup>+</sup>). HPLC (Method A): Rt<sub>T</sub> = 6.37 minutes.
(d) By a similar procedure to that described in Example 16 (a), but using (6-phenyl-5 H -pyrrolo [2,3- b] pyrazin-7-yl) acetic acid
209 [Reference Example 35], 2- (6-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) ethanol was prepared as a colorless solid, mp 201-202 ° C. Mass Spectrum: 348 (MH +);<sup>+</sup>). HPLC (Method A): Rt<sub>T</sub> = 6.37 minutes. [Elemental analysis: C, 70.68; H, 5.77; N, 17.44%. Calcd. For C 13 H 11 N 3 O: C, 70.28; H, 5.48; N, 17.56%].
(e) In a similar manner to that described in Example 16 (a), but using [2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenoxy] -acetic acid ethyl ester [Example 27 ], 2- [2-methoxy-5- (57H-pyrrolo [2,3-b] pyrazin-6-yl) -phenoxy] -ethanol was prepared as a yellow solid, mp 203-205 ° C. Mass Spectrum: 286 (MH +);<sup>+</sup>) .
(f) By a similar procedure to that described in Example 16 (a), but using 3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] propionic acid ethyl ester [ Reference Example 38 (b)], 3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenyl] -propan-1-ol was prepared as a yellow solid at temperature mp 203-204 ° C. Mass Spectrum: 297 (MH +);<sup>+</sup>) .
(g) By a similar procedure to that described in Example 16 (a), but using 3- {6- [4- (1-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid [Example 25 (b)], 7 mg of 3- {6- [4- (1-methyl) ethoxyphenyl] -5 H -pyrrolo [2,3- b] pyrazin-7-yl] propanol was prepared as a yellow solid substances. Mass Spectrum: 312 (MH +);<sup>+</sup>) .
HPLC (Method C): Rt<sub>T</sub> = 2.9 minutes.
Example 17 (a) 2- (5-Methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine
To a solution of 1.45 g of 2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [reference example] 13 (b)] in 100 ml of methanol is added 15 ml of 5 M potassium hydroxide solution and the mixture is heated at reflux for 2 hours. The reaction mixture was cooled and then evaporated, the residue was evaporated
210 The resulting solid was collected by filtration and then dried to give 0.75 g of the title compound as a tan solid, mp 226-227 ° C. Mass Spectrum: 278 (MH +);<sup>+</sup>) .
(b) By a similar procedure to that described in Example 17 (a), but using 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine]. 2-yl] -1H-indol-5-yloxy} propane-1,2-diol [Reference Example 16], prepare 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyridine); 2-yl) -1H-indol-5-yloxy] propane-1,2-diol as a colorless solid, m.p. 202-203 ° C. Mass Spectrum: 338 (MH +);<sup>+</sup>) .
(c) In a similar manner to that described in Example 17 (a), but using 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -ΙΗ-pyrrolo [2,3-b] pyridine]; 2-yl] -1H-indol-5-yloxy} propan-1-ol [Reference Example 17] was prepared 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) 1 H-Indol-5-yloxy] propan-1-ol as a yellow solid, mp 192-193 ° C. Mass Spectrum: 322 (MH +);<sup>+</sup>) .
(d) In a similar manner to that described in Example 17 (a), but using 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine]; 2-yl] -1H-indol-5-yloxy} propan-2-ol [Reference Example 17], prepare 3- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2- yl) -1H-indol-5-yloxy] propan-2-ol as a yellow solid, m.p. 201-202 ° C. Mass Spectrum: 322 (MH +);<sup>+</sup>) .
(e) By a similar procedure to that described in Example 17 (a), but using 2- [1-methyl-5- (1-trimethylstananyl-1H-tetrazol-5-yl) -1H-indol-3-yl] - 1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 20], prepare 2- [1-methyl-5- (2H-tetrazol-5-yl) -1H-pyrrolidin-2-yl] -1H-pyrrolo [2,3-b] pyridine. indol-3-yl] -1H-pyrrolo [2,3-b] pyridine as a yellow solid, mp 303 ° C. Mass Spec .: 316 (MH).
(f) By a similar procedure to that described in Example 17 (a), but using 2- [1-methyl-5- (2-methyl-2H-tetrazol-5-yl) -1H-indol-3-yl] - 1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 21], 2- [1-methyl-5- (2-methyl-2H-tetrazole-5-) was prepared. yl) 1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine as a beige solid, mp 299-300 ° C (dec.). Mass Spectrum: 330 (MH +);<sup>+</sup>) .
(g) By a similar procedure to that described in Example 17 (a), but using 2- [1-methyl-5- (1-methyl-1H-tetrazol-5-yl) -1H-indol-3-yl] - 1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 21], prepared 2- [1-methyl-5- (1-methyl-1H-tetrazol-5-yl)] 1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine as a beige solid, mp 286-289 ° C (dec.). Mass Spectrum: 330 (MH +);<sup>+</sup>) .
(h.) In a similar manner to that described in Example 17 (a), but using 1- [1-methyl-3 - {(1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl} -1H-indol-5-yl] ethanone [Reference Example 22], prepare 1- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl)] 1 H-indol-5-yl] ethanone as a beige solid, m.p. 210 DEG C. (decomposition) Mass spectrum: 290 (MH @ +).<sup>+</sup>) .
(i) By a similar procedure to that described in Example 17 (a), but using 2- (5,6-dimethoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) - 1H-pyrrolo [2,3-b] pyridine [Reference Example 13 (d)], prepare 2- (5,6-dimethoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [ 2,3-b] pyridine as a beige solid, m.p. 283-285 ° C (dec.). Mass Spectrum: 308 (MH +);<sup>+</sup>) .
(j) By a similar procedure to that described in Example 17 (a), but using (S) -3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-] b] pyrid-2-yl] -1H-indol-5-yloxy} propane-1,2-diol [Reference Example 24 (a)], prepare (S) -3- [1-methyl-3- (1H) - pyrrolo [2,3-b] pyridin-2-yl) -1H-indol-5-yloxy] propane-1,2-diol as a colorless solid, m.p. 182-185 ° C. Mass Spectrum: 338 (MH +)<sup>+</sup>) .
(k) By a similar procedure to that described in Example 17 (a), but after 212 using (R) -3- {1-methyl-3- [1- (toluene-4-sulfonyl) -ΙΗ-pyrrolo [2,3] (1 H) -pyrid-2-yl] -1 H -indol-5-yloxy} propane-1,2-diol [Reference Example 24 (b)], prepare (R) -3- [1-methyl-3- ( 1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] propane-1,2-diol as a colorless solid, mp 153-156 ° C. Mass Spectrum: 338 (MH +);<sup>4-</sup>) .
(1) In a similar manner to that described in Example 17 (a), but using 2- [5- (2-methoxy-1-methylethoxy) -1-methyl-1H-indol-3-yl] -1- (toluene) -4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 25], 2- [5- (2-methoxy-1-methylethoxy) -1-methyl-1H-indole-3- yl] -1H-pyrrolo [2,3-b] pyridine as a yellow solid, mp 150-151 ° C. Mass Spectrum: 336 (MH +);<sup>+</sup>) .
(m) In a similar manner to that described in Example 17 (a), but using 2- [1-methyl-5- (5-methyl-1,2,4-oxadiazol-3-yl) -1 H -indole-3 -yl] -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 27], prepare 2- [1-methyl-5- (5-methyl-1,2) 4-oxadiazol-3-yl) -1H-indol-3-yl] -1H-pyrrolo [2,3-b] pyridine as a cream colored solid, m.p. 290-294 ° C. Mass Spectrum: 330 (MH +);<sup>+</sup>) .
(n) By a similar procedure to that described in Example 17 (a), but using (S) -3- (6-methoxy-1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [ 2,3-b] pyrid-2-yl] -1H-indol-5-yloxy [propane-1,2-diol [Reference Example 24 (c)], prepare (S) -3- [6-methoxy- 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yloxy] propane-1,2-diol as a cream-colored solid Mass spectrum: 368 (MH<sup>+</sup>). HPLC (Method A): Rt<sub>T</sub> = 5.81 minutes.
(o) In a similar manner to that described in Example 17 (a), but using 2- (5-hydroxy-6-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) 1 H -pyrrolo [2,3- b] pyridine [Reference Example 28], 6-methoxy-1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H is prepared -indol-5-ol as a brown solid. Mass Spectrum: 294 (MH +);<sup>+</sup>). HPLC (Method A): Rt<sub>T</sub> = 6.37 minutes.
213 (p) In a similar manner to that described in Example 17 (a), but using 2- (5-methoxy-1-methyl-1H-indol-3-yl) -4-phenyl-1- (toluene-4-sulfonyl) 1H-pyrrolo [2,3-b] pyridine [Reference Example 2 (m)], prepared 2- (5-methoxy-1-methyl-1H-indol-3-yl) -4-phenyl-1H- pyrrolo [2,3-b] pyridine as a yellow solid. @ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]; δ 11.98 (1H, s); 8.21 (1H, d, J = 3.5Hz); 7.94 (1 H, s); 7.86 (2H, d, J = 8.8Hz); 7.59 (2H, t, J = 8.8Hz); 7.47 (2 H, m); 7.39 (1H, d, J = 1.9Hz); 7.17 (1H, d, J = 3.5Hz); 6.93 (1H, dd, J = 8.8 and 1.9 Hz); 6.82 (1 H, s); 3.84 (3 H, s); 3.82 (3 H, s).
(q) By a similar procedure to that described in Example 17 (a), but using 2- [5- (pyrid-4-yl) -1-methyl-1H-indol-3-yl] -1- (toluene- 4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine (Reference Example 60), 2- [1-methyl-5- (pyrid-4-yl) -1H-indol-3-yl] - 4-1H-pyrrolo [2,3-b] pyridine as a yellow solid, m.p. 325-330 ° C. @ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]; Ô 8.65 (2H, d, J = 7.2Hz); 8.20 (1 H, s); 8.15 (1 H, m); 8.04 (1 H, s); 7.88 (3 H, m); 7.72 (2 H, m); 7.03 (1H, t, J = 7.2Hz); 6.96 (1 H, s); 3.93 (3 H, s).
(r) By a similar procedure to that described in Example 17 (a), but using 2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H- pyrrolo [2,3-b] pyridine-4-carbonitrile [Reference Example 13 (h)], prepared 2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2] 3-b] pyridine-4-carbonitrile as an orange-colored solid, m.p. 304-305 ° C. @ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 12.60 (1 H, s); 8.24 (1 H, s); 8.07 (1 H, s); 7.50 (3 H, m); 6.96 (1H, d, J = 8.6Hz); 6.88 (1 H, s); 3.91 (3 H, s); 3.86 (3 H, s).
(s) By a similar procedure to that described in Example 17 (a), but using 4-chloro-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) 1H-pyrrolo [2,3-b] pyridine [Reference Example 13 (i)], 4-chloro-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H- pyrrolo [2,3-b] pyridine as a yellow-brown solid, mp 250-252 ° C. Mass Spectrum: 312 (MH +);<sup>+</sup>) .
Example 18
214 l-methyl-3- (ΙΗ-pyrrolo [2,3-b] pyridin-2-yl) -lH-indol-5-ylamine
To a stirring solution of 0.2 g of [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yl] carbamic acid tert-butyl ester [reference Example 30] in dichloromethane was added 2 mL of three fluoroacetic acid. The mixture was stirred at room temperature for 16 hours and then evaporated. The residue was suspended in 10 mL of saturated sodium bicarbonate solution and the resulting solid was filtered off and then dried to give the title compound as a yellow solid, mp 247-248 ° C. Mass Spectrum: 263 (MH +);<sup>+</sup>) .
Example 19 (a) N- [1-Methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yl] methanesulfonamide
A solution of 52.4 mg of 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-ylamine [Example 18] in 5 ml of dichloromethane is treated with 30 μΐ of triethylamine and then with 17 μΐ of methanesulfonyl chloride. After stirring at room temperature for 16 hours, the reaction mixture was diluted with 10 mL of dichloromethane, then washed with 10 mL of water and 10 mL of brine, dried over magnesium sulfate and evaporated. The solid obtained was triturated with diethyl ether to give the title compound as a yellow solid, mp 223-224 ° C. Mass Spectrum: 341 (MH +);<sup>+</sup>) .
(b) Following a similar procedure to that described in Example 19 (a), but using acetyl chloride, N- [1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) was prepared. 1H-Indol-5-yl] acetamide as a yellow solid, m.p. 220-221 ° C. Mass Spectrum: 305 (MH +);<sup>+</sup>) .
Example 20 (a) {1- [5- (1-Hydroxymethyl-cyclobutyloxy) -3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -indol-1-yl] -cyclobutyl] -methanol
215
A stirred solution of 0.54 g of 1- {1- (cyclobutanecarboxylic acid ethyl ester) -3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] - ethyl ester - 1H-Indol-5-yloxy} cyclobutanecarboxylic acid [Reference Example 23 (d)] in 50 ml of tetrahydrofuran at 0 ° C under nitrogen atmosphere is treated dropwise with 4.9 ml of a 1.0 M solution of 11-aluminum aluminum hydride in tetrahydrofuran. After stirring at 0 ° C for 2 hours, the reaction mixture is allowed to stand for 18 hours at room temperature, then 20 ml of water is added dropwise and the mixture is filtered through Hyflo Super Cel®. The filter cake was washed with 20 mL of ethyl acetate, the biphasic filtrate was separated and the aqueous layer was extracted twice with 25 mL of ethyl acetate. The combined organic phases are washed with 25 ml of brine, then dried over magnesium sulphate and evaporated. The residue was triturated with diethyl ether and the insoluble material was purified by flash chromatography on silica gel, eluting with dichloromethane: methanol (19: 1, v / v) to give the title compound as a cream colored solid (0.19 g), m.p. Mp 165-166 ° C. Mass Spectrum: 418 (MH +)<sup>+</sup>) .
(b) In a similar manner to that described in Example 20 (a), but using {1- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-] ethyl ester indol-5-yloxy] cyclobutanecarboxylic acid [Reference Example 15 (e)]: {1- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5] -yloxy] cyclobutyl] methanol as a brown solid, m.p. 267-271 ° C. Mass Spectrum: 349 (MH +);<sup>+</sup>) .
Example 21 (a) 2- (5-Methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine methanesulfonate μΐ methanesulfonic acid is added to a solution of 300 mg at room temperature 2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine [Example 17 (a)] in 20 mL of tetrahydrofuran.
The mixture was stirred for 45 minutes and the resulting precipitate was filtered off to give 390 mg of the title compound as a yellow solid, mp 256-257 ° C. [Elemental analysis: C, 57.60; H, 4.77; N, 10.90%. Calculated for Ci<sub>3</sub>HNN<sub>3</sub>O: C, 57.90; H, 5.13; N, 11.25%].
(b) By a similar procedure to that described in Example 21 (a), but using 6- (5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine [ Example 1 (a)], 6- (5-methoxy-1-methyl-1H-indol-3-yl) -5H-pyrrolo [2,3-b] pyrazine methanesulfonate was prepared as a yellow solid, m.p. 245-250 ° C. C. Mass Spectrum: 279 (MH +);<sup>+</sup>) .
(c) By a similar procedure to that described in Example 21 (a), but using 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) indol-1-yl] -
of 1-morpholin-4-yl-ethanone [Example 14 (a)], 2- [5-methoxy-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -indol-1-yl] was prepared -1-morpholin-4-yl-ethanone methanesulfonate as a yellow solid, m.p. 214-215 ° C. Mass Spectrum: 391 (MH +)<sup>+</sup>) .
in Example 1-methyl-3 [Example (d) By a similar procedure to that described using (2-hydroxy-1,1-dimethylethyl) acid amide
- (lH-pyrrolo [2,3-b] pyridin-2-yl) -lH-indole-5-carboxylic acid
14 (m)], 1-methyl-3- (1H-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5 (2-hydroxy-1,1-dimethylethyl) amide methanesulfonate is prepared carboxylic acid as a yellow solid, m.p.
1-92 ° C. Mass Spectrum: 363 (MH +);<sup>+</sup>) .
(e) By a similar procedure to that described in Example 21 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazine-) (2-hydroxy-1,1-dimethylethyl) amide. 6-yl) -1H-indole-5-carboxylic acid [Example 14 (s)], 2- [5- (2-hydroxy-1,1-dimethylethylcarbamoyl) -1-methyl-1H-indol-3-yl] - 1H-pyrrolo [2,3-b] pyrazine methanesulfonate as a brown solid, mp 240 ° C (dec.).
<sup>X</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 8.50 (1H, s); 8.37 (1H, d, J = 3.0Hz); 8.32 (1H, d, J = 3.0Hz); 8.29 (1 H, s); 7.82 (1H, d, J = 8.2Hz);
7.77 (1 H, s); 7.64 (1H, d, J = 8.2Hz); 7.20 (1 H, s); 3.95 (3H,
217
with); 3.59 (2 H, s); 2.37 (3 H, s); 1.38 (6 H, s).
(f) By a similar procedure to that described in Example 21 (a), but using 2- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1]. -yl] -
-1-morpholin-4-yl-ethanone (Example 12), 2- [5-methoxy-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] - 1-Morpholin-4-yl-ethanone methanesulfonate, m.p. 250 ° C. <sup>1</sup>1 H-NMR [(CD 3)]<sub>2</sub>SO]: δ 8.32 (1H, s); 8.22 (1 H, s); 8.11 (1 H, s); 7.50 (1 H, s); 7.44 (1H, d, J = 8.8Hz); 7.04 (1 H, s); 6.93 (1H, d, J = 8.8Hz); 5.36 (2 H, s); 3.90 (3 H, s); 3.61 (8 H, m); 2.31 (3 H, s).
Example 22
5- [6- (4- tert -Butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] ethyl-2H-tetrazole
To a stirred solution of 0.2 g of 3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] -propio- nitrile [Example 23] in 25 ml of toluene under nitrogen at temperature room adds
0.61 ml of azidotributyltin. The reaction mixture is warmed to temperature
117 ° C. After 24 hours, an additional aliquot of 0.21 mL of azidotributyltin was added and the reaction was heated for hours. The reaction was quenched by the addition of 44 mL of acetic acid, stirred for 15 minutes and extracted for an additional 24 g of glacial acid between water and ethyl acetate. The two layers were separated, water, dried over magnesium sulfate and purified by column chromatography eluting with ethyl acetate to give 0.06 g of the organic evaporated phase, washed. The remainder of the silica gel, the title compound being the title as an off-white solid. Mass Spectrum: 348 (MH +);<sup>+</sup>). HPLC (Method B): Rt<sub>T</sub> = 1.64 minutes.
Example 23
3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] -2Hpropionitril
To a solution of 0.1 g of 3- [6- (4- tert -butylphenyl-5 H -pyrrolo [2,3- b] pyrazin-7-yl] propionamide [Example 24] in 15 mL of tetrahydrofuran at room temperature triethylamine (1 ml) and phosphorus pentoxide (1 ml) were added and the reaction mixture was refluxed with sodium bicarbonate solution.
and combined organic heats and then
The mixture is poured over 30 minutes and extracted into 10% ethyl acetate extracts, washed with water, dried over magnesium sulphate and evaporated
The residue is purified by flash chromatography on silica gel, eluting first with a mixture of m.p. (v / v) and then ethylation to give the title compound as a white solid, mp 215-216 ° C. Mass spectrum:
305 (MH<sup>+</sup>) .
Example 24
3- [6- (4-tert-Butyl-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] -propionamide
To a solution of 0.51 g of 3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid [Example 25 (a)] in 15 ml of dimethylformamide was added in nitrogen 0.54 g of O-benzotriazol-1-yl-N, N, N ', N'-tetramethyluronium tetrafluoroborate and 0.22 ml of triethylamine are added at room temperature and ammonia gas is bubbled through the solution for 5 minutes and the reaction mixture is allowed to stand at room temperature. The solution was then poured into water and extracted with ethyl acetate. The organic extracts were washed with water and dried over sodium sulfate to give the title compound which was used without further purification. Mass Spectrum: 323 (MH +);<sup>+</sup>). HPLC (Method B): Rt<sub>T</sub> = 4.49 minutes.
Example 25 (a) 3- [6- (4-tert-Butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) propionic acid
To a solution of 0.4 g of dimethyl 3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] propionate-1,1-dicarboxylate [Reference Example 217] (a)] in 20 ml of methanol, 4 ml of 1 N sodium hydroxide solution are added, and the reaction mixture is heated at 50 ° C for 6 hours, then left to stand at room temperature overnight. sulfuric acid solution and the reaction mixture is heated at reflux for 2 hours. After cooling, the solution was basified to pH 4 with 6 N sodium hydroxide solution and the resulting precipitate was filtered off and dried in vacuo to give 0.26 g of the title compound as an off-white solid, m.p. 274-275 ° C. is used without further purification. Mass Spectrum: 324 (MH +);<sup>+</sup>) .
(b) By a similar procedure to that described in Example 25 (a), but using dimethyl 3- [6- (4- (1-methyl) ethoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine-7- yl] propion-1,1-dicarboxylate [Reference Example 44 (b)], 3- {6- [4- (1-methyl) ethoxyphenyl] -5 H -pyrrolo [2,3- b] pyrazine acid is prepared -7-yl [propionic acid as a yellow solid. Mass Spectrum: 326 (MH +);<sup>+</sup>). HPLC (Method C): R p = 1.56 minutes.
(c) By a similar procedure to that described in Example 25 (a), but using dimethyl 3- [6- (4-fluorophenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propion-1 1,1-dicarboxylate [Reference Example 44 (c)], 3- [6- (4-fluorophenyl) -5 H -pyrrolo [2,3- b] pyrazin-7-yl] propionic acid was prepared in the form of an off-white solid. <sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 12.3 (s, 1H); 8.4 (d, 1H); 8.2 (d, 1H); 7.8 (d, 2H); 7.4 (d, 1H);
2H), 3.1 (t, 2H), 2.7 (t, 2H). Mass Spectrum: 285 (MH +).
(d) By a similar procedure to that described in Example 25 (a), but using dimethyl-3- [6- (4-methoxyphenyl) -5,7-pyrrolo [2,3-b] pyrazin-7yl] propion-1 1-dicarboxylate [Reference Example 44 (d)], 3- [6- (4-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid was prepared as an off-white solid. @ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 12.0 (s, 1H), 8.3 (d, 1H), 8.2 (d, 1H), 7.7 (d, 2H), 7.1 (d, 2H),
3.8 (s, 3H), 3.05 (t, 2H), 2.6 (t, 2H). Mass Spectrum: 297 (MH +);<sup>+</sup>) .
220
Example 26
3- [6- (4-tert-Butyl-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -propan-1-ol
To a mixture of 5 ml of 4 N hydrochloric acid in dioxane (1: 1, v / v) was added 0.02 g of 3- [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] acid. After stirring at room temperature overnight, the residue is suspended between 10% sodium bicarbonate solution and ethyl acetate, the phases are separated and the organic phase is washed with water and dried over sodium sulphate. ether. 0.12 ml of a 1 M solution of lithium aluminum hydride in diethyl ether is added and the suspension is heated to reflux for 2 hours. An additional aliquot of 0.12 mL of a 1 M solution of lithium aluminum hydride in diethyl ether was added and the reaction mixture was heated at reflux for a further 1 hour. The reaction was quenched by dropwise addition of cold 10% aqueous potassium bicarbonate solution until hydrogen evolution ceased, diluted with water and extracted with ether. The combined organic fractions were washed with water, dried over sodium sulfate and purified by flash chromatography on silica gel eluting with ethyl acetate to give 0.035 g of the title compound as an off-white solid, mp 187-189 ° C. Mass Spectrum: 310 (MH +);<sup>+</sup>) .
Example 27
[2-Methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenoxy] -acetic acid ethyl ester
To a solution of 0.5 g of 2-methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenol [Example 28] in 10 ml of dimethylformamide and 0.67 g of cesium carbonate was added 0.025 g of ethyl chloroacetate. . The reaction mixture was heated at 50 ° C overnight. After cooling, the dimethylformamide was evaporated in vacuo and the residue was partitioned between ethyl acetate and water.
221
The organic fractions were dried over sodium sulfate, evaporated and purified by flash chromatography on silica gel, eluting with 2.5% methanol in dichloromethane. The product was further triturated with ethyl acetate-pentane to give the title compound as a white solid, mp 183-184 ° C. Mass Spectrum: 328 (MH +);<sup>+</sup>) .
Example 28
2-Methoxy-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenol
To a solution of 1.0 g of 6- [3- (tert-butyldimethylsilyloxy) -4-methoxy] phenyl-5 H -pyrrolo [2,3- b] pyrazine [Reference Example 49] in 50 mL of tetrahydrofuran is added 5.63. ml of a 1 M solution of tetraburylammonium fluoride in tetrahydrofuran. The reaction mixture was stirred for 3 hours at room temperature. The tetrahydrofuran was evaporated under reduced pressure and the residue was suspended in water. The resulting solid was filtered and dried under vacuum to give 0.56 g of the title compound as a white solid, which was used without further purification. Mass Spectrum: 242 (MH +);<sup>+</sup>) .
HPLC (Method B): R p = 3.02 minutes.
Example 29
3-Fluoro-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine
A solution of 0.1 g of (5-methoxy-1-methyl-1H-indol-3-yl) -1H-pyrrolo [2,3-b] pyridine [Example 17 (a)] in 4 ml of dry tetrahydrofuran at at 0 ° C was reacted with 0.042 ml of methylmagnesium bromide and after stirring for 20 minutes this mixture was treated with 0.13 g of 1-chloromethyl-4-fluoro-1,4-diazonium bicyclo [2.2.2] octanebis (tetrafluoroborate). The reaction mixture was stirred at room temperature for 4 hours, allowed to stand overnight at room temperature, then heated at 40 ° C for 4 hours and at 80 ° C for 2 hours, cooled to room temperature and extracted between acetate
222 and water. The aqueous layer was extracted three times with 25 mL of ethyl acetate. The combined extracts and ethyl acetate layer were washed with brine, dried over magnesium sulfate and then evaporated. The residue was triturated with ethyl acetate to give 0.057 g of the title compound as a white solid, mp 248-250 ° C.<sup>1</sup>@ 1 H-NMR .delta<sub>3</sub>)<sub>2</sub>SO]: δ 12.20 (1H, s); 8.24 (1H, m); 7.81 (1 H,
<td>with) ;</td><td> 7,79</td><td>(1 H,</td><td>d.</td><td>J = 9.6</td><td>Hz);</td><td> 7,46</td><td>(1 H,</td><td>d.</td><td>J</td><td>= 9.6 Hz);</td><td> 7,27</td>
<td>(1 H,</td><td>with) ;</td><td> 7,18</td><td>(1 H,</td><td>dd, J =</td><td> 13, 1</td><td>and 6.0</td><td>Hz);</td><td> 6,</td><td> 90</td><td>(LH, d, J)</td><td> = 9,6</td>
<td>Hz);</td><td> 3,88</td><td colspan="2">(3H, s);</td><td>3.80 (3H</td><td>, with) .</td><td></td><td></td><td></td><td></td><td></td><td></td>
Example 30
3- {6- (4-Hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -propionic acid
To a solution of 0.77 g of dimethyl 3- [6- (4- (1-methyl) ethoxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionate-1,1-dicarboxylate [Reference Example 44 ( b)] in 45 ml of methanol is added 7.7 ml of 1N sodium hydroxide solution. The reaction mixture was heated at 50 ° C for 6 hours and then allowed to stand overnight at room temperature. The solvent was evaporated, 20 ml of a 6 N sulfuric acid solution was added and the reaction mixture was heated to reflux for 12 hours. After cooling, the solution was basified to pH 4 by the addition of 4 N sodium hydroxide solution and the resulting precipitate was filtered off and dried in vacuo to give 0.42 g of the title compound as a yellow solid, which was used without further purification. Mass Spectrum: 284 (MH +);<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 2.3 minutes.
Example 31
3- {6- (4-Hydroxy-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl} -propionic acid ethyl ester
A solution of 0.02 g of 3- {6- (4-hydroxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionic acid [Example 30] in 2 ml of ethanol
223 reacts with a catalytic amount of p-toluenesulfonic acid. The mixture was heated at reflux for 4 hours, the solvent was evaporated and the precipitate was filtered off. The solid is taken up in ethyl acetate, the organic layer is washed with water and brine, dried over magnesium sulfate and evaporated to give a yellow solid which is purified by flash chromatography on silica gel eluting with ethyl acetate to give the title compound. in the title. Mass Spectrum: 298 (MH +);<sup>+</sup>). HPLC (Method C): R p = 2.58 minutes.
Example 32 and Reference Example 100
2- (5-methoxy-lH-indol-3-yl) pyrrolo [2,3-b] pyridine-4-carbonitrile
In a similar manner to that described in Reference Example 12 (a), but using 2-iodo-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine-4-carbonitrile [Reference Example 62 (a)] the title compound was prepared as a yellow solid, mp 303-304 ° C [TLC: R p = 0.07 (ethyl acetate / heptane 1: D), and
2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine-4-carbonitrile [Reference Example 100] as a brown oil [Mass Spectrum: 443 (MH +)<sup>+</sup>); TLC: Rf = 0.38 (ethyl acetate / heptane 1: 1)].
Example 33
6- (4-methylsulfinylphenyl) -5H-pyrrolo [2,3-b] pyrazine
A stirred suspension of 0.2362 g of 6- (4-methylthiophenyl) -5H-pyrrolo [2,3-b] pyrazine [Example 1 (ah)] in 20 mL of dichloromethane is treated with 2.545 g of TBA oxone. After 2 hours, the resulting orange solution was evaporated. The residue was purified by flash chromatography eluting with methanol / dichloromethane (1: 1, v / v) to give the title compound as a white solid. Mass Spectrum: 258 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR [(CD 3)]<sub>2</sub>SO]: δ 12.66 (1 H,
with); 8.41 (1 H, s); 8.24 (3 H, m); 7.82 (2H, d, J = 8.7Hz); 7.33
224 (1Η, s); 2.81 (3 H, s).
Example 34
6- (4-Methylsulfonylphenyl) -5H-pyrrolo [2,3-b] pyrazine
A stirred suspension of 0.125 g of 6- (4-methylthiophenyl) -5H-pyrrolo [2,3-b] pyrazine [Example 1 (ah)] in 15 ml of dichloromethane is treated with 1.35 g of TBA oxone. After 4 hours, the reaction mixture was evaporated. The residue was purified by flash chromatography eluting with methanol / dichloromethane (1: 1, v / v) to give the title compound as a white solid. Mass Spectrum: 274 (MH +);<sup>+</sup>) . <sup>2</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 12.78 (1H, s); 8.44 (1 H, s); 8.28 (3 H, m); 8.04 (2H, d, J = 8.8Hz); 7.40 (1 H, s); 3.27 (3 H, s).
Example 35
3- (6- (4-tert-Butyl-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propylamine
A solution of 0.2 g of 3- [6- (4- tert -butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] propionamide [Example 24] in 20 ml of dry tetrahydrofuran is treated with 5 ml of a 1M solution of lithium aluminum hydride The solution was stirred for 24 hours at room temperature and then treated with 20 mL of water, filtered through diatomaceous earth and the diatomaceous earth was washed twice with 20 mL of ether. The combined filtrates were washed with water, then brine, dried over magnesium sulfate and evaporated to give the title compound as a yellow solid (0.12 g). Mass Spectrum: 309 (MH +);<sup>+</sup>). HPLC (Method C): R t = 2.54 minutes.
Example 36 (a) N- {3- (6- (4-tert-Butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) -propyl} acetamide
A solution of 0.0324 mmol of 3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3225]
-b] pyrazin-7-yl) propylamine [Example 35] in 1.5 ml of tetrahydrofuran is treated with 0.0324 mmol of acetyl chloride and 0.0788 mmol of triethylamine. The solution was stirred for 12 hours at room temperature and then treated with water and ethyl acetate. The organic phase is dried over magnesium sulphate and then evaporated. The residue was purified by silica gel column chromatography eluting with ethyl acetate and then with a mixture of ethyl acetate and methanol (9: 1, v / v) to give the title compound as a yellow solid. Mass Spectrum: 351 (MH +);<sup>+</sup>). HPLC (Method C): Ry = 3.05 minutes.
(b) Following a similar procedure to that described in Example 36 (a) but using cyclopropylcarbonyl chloride, N {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b]) was prepared. pyrazin-7-yl) propyl} -cyclopropylcarboxylic acid as a yellow gummy solid. Mass Spectrum: 377 (MH +);<sup>+</sup>). HPLC (Method C): R y = 3.25 minutes.
(c) Following a similar procedure to that described in Example 36 (a) but using n-butyryl chloride, N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b]) was prepared. pyrazin-7-yl) propyl (butyramide as a yellow gummy solid) Mass Spectrum: 379 (MH +)<sup>+</sup>). HPLC (Method C): Ry = 3.28 minutes.
(d) Following a similar procedure to that described in Example 36 (a), but using methoxyacetyl chloride, N- (3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b]) was prepared. pyrazin-7-yl) propyl} methoxyaceramide as a yellow solid Mass Spec .: 381 (MH +)<sup>+</sup>). HPLC (Method C): R y = 3.15 minutes.
(e) Following a similar procedure to that described in Example 36 (a), but using thien-2-ylcarbonyl chloride, the N {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2, 6-tert-butylphenyl] acid) was prepared. 3-b] pyrazin-7-yl) propyl} -thien-2-ylcarboxylic acid as a yellow solid. Mass Spectrum: 419 (MH +)<sup>+</sup>). HPLC (Method C): Ry = 3.28 minutes.
Example 37
226 (a) N- {3- (β- (4-tert-Butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) -propyl} -N'-n-propylurea
A solution of 0.0324 mmol of 3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propylamine [Example 24] in 2 mL of tetrahydrofuran is treated with 0.0324 mmol n-propyl isocyanate. The solution is stirred for 12 hours at room temperature and then treated with 3 ml of water. The resulting precipitate was filtered off, then washed with water and dried under vacuum at 50 ° C to give the title compound as a beige solid. Mass Spectrum: 394 (MH +)<sup>+</sup>HPLC (method C): = 3.25 minutes.
b) Following a similar procedure to that described in Example 37 (a), but using ethyl isocyanatoacetate, N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazine-7) was prepared. -yl) propyl} -N'-ethoxycarbonylmethyl urea as a yellow solid. Mass Spectrum: MH + 437;<sup>+</sup>). HPLC (Method C): Rt<sub>T</sub> = 3.18 minutes.
Example 38
N- {3- (6- (4- tert -Butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) -propyl} -N ', N'-diethylurea
A solution of 3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl) propylamine [Example 24] (0.0324 mmol) in 1.5 mL of tetrahydrofuran is treated with 0324 mmol of diethylcarbamoyl chloride and 0.0788 mmol of triethylamine. The solution was stirred for 12 hours at room temperature and water and ethyl acetate were added. The layers were separated and the organic solution was dried over magnesium sulfate. The desiccant was filtered off and the solvent was evaporated. The residue was purified by silica gel column chromatography eluting with ethyl acetate and then 10% methanol in ethyl acetate to give the title compound as a yellow solid. Mass Spectrum: 408 (MH +);<sup>+</sup>). HPLC (Method C): R? = 3.43 minutes.
Example 39
227 (a) N- {3- (6- (4-tert-Butylphenyl) -5H-pyrrolo [2,3-b] pyrimidin-7-yl) -propyl} methanesulfonamide
A solution of 3- (6- (4-tert-butylphenyl) -5 H -pyrrolo [2,3- b] pyrazin-7-yl) propylamine [0.0244 mmol] [Example 24] in 1.5 mL of tetrahydrofuran is reacted. with 0.0324 mmol of methanesulfonyl chloride and 0.0788 mmol of triethylamine. The solution was stirred for 12 hours at room temperature and ethyl acetate was added. The layers were separated and the solvent was evaporated. The residue was purified by silica gel column chromatography eluting with ethyl acetate and then 10% methanol in ethyl acetate to give the title compound as a yellow solid. Mass Spectrum: 387 (MH +)<sup>+</sup>). HPLC (method
C): R t = 3.23 minutes.
(b) Following a similar procedure to that described in Example 39 (a), but using thien-2-ylsulfonyl chloride, N- {3- (6- (4-tert-butylphenyl) -5 H-) - was prepared. pyrrolo [2,3-b] pyrazin-7-yl) propyl} thien-2-ylsulfonamide as a yellow solid. Mass Spectrum: 455 (MH +);<sup>+</sup>) .
HPLC (Method C): R p = 3.56 minutes.
(c) Using a similar procedure to that described in Example 39 (a), but using 3,5-dimethylisoxazol-4-ylsulfonyl chloride, N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [4-a] is obtained. 2,3-b] pyrazin-7-yl) propyl} dimethylisoxazol-4-ylsulfonamide as a white gummy solid. Mass Spectrum: 468 (MH +);<sup>T</sup>). HPLC (Method C): R p = 3.55 minutes.
(c) Following a procedure similar to that described in Example 39 (a), but using 1-methylimidazol-4-ylsulfonyl chloride, N- {3- (6- (4-tert-butylphenyl) -5H-pyrrolo [2, 3, 4, 5-methylphenyl] -5H-pyrrolo [2, 3-b] pyrazin-7-yl) propyl} -1-methylimidazol-4-ylsulfonamide as a white gummy solid. Mass Spectrum: 453 (MH +)<sup>+</sup>). HPLC (method C):
R t = 3.13 minutes.
Reference example 1
228 (a) 5-Methoxy-1-methyl-1H-indole-3-carbonitrile 5-methoxy-1-methyl-1H-indole-3-carboxaldehyde [Reference Example 2 (a)] and 55.9 g of hydroxylamine hydrochloride The mixture is stirred with 900 ml of dimethylformamide at reflux for 1 hour. The mixture was allowed to cool, then poured into water and extracted with ethyl acetate. The combined extracts were washed with water and then evaporated to give 53 g of the title compound as a light brown solid, mp 100-104 ° C. <sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 8.17 (1H, s); 7.54 (1H, d, J = 9.0Hz); 7.09 (1H, d, J = 2.4Hz); 6.97 (1H, dd, J = 9.0 and 2.4 Hz); 3,82 and 3,84 (6H, s).
(b) In a similar manner to that described in Reference Example 1 (a), but using 1-methyl-5-phenylpyrazole-3-carboxaldehyde [Reference Example 53 (b)] to prepare 1-methyl-3-cyano-5- phenylpyrazole.
Reference Example 2 (a) 5-Methoxy-1-methyl-1H-indole-3-carboxaldehyde
A solution of 80 g of 5-methoxyindole-3-carboxaldehyde vil dimethylformamide in portions under nitrogen was treated portionwise over 15 minutes with 20.1 g of sodium hydride (60% dispersion in mineral oil). After stirring at room temperature for 30 minutes, the mixture was treated dropwise with methyl iodide (31.3 ml) over 10 minutes and stirring was continued for a further 2 hours. The reaction mixture was carefully poured into water and then extracted with ethyl acetate. The organic phase is washed with water, dried over sodium sulphate and then evaporated. The residue was triturated with pentane to give 76 g of the title compound as a light brown solid, mp 133-134 ° C.<sup>1</sup>1 H-NMR [(CD<sub>3</sub>) 2 SiO: δ 9.86 (1H, s);
8.20 (1 H, s); 7.60 (1H, d, J = 2.6Hz); 7.50 (1H, d, J = 8.9Hz); 6.96 (1H, dd, J = 8.9 and 2.6 Hz); 3.86 and 3.80 (6H, s).
229 (b) In a similar manner to that described in Reference Example 2 (a), but using indole-3-carbonitrile, 1-methyl-1H-indole-3-carbonitrile was prepared as a colorless crystalline solid, mp 61-63 ° C.
(c) In a similar manner to that described in the reference example
f.
2 (a), but using indole-5-carbonitrile, 1-methyl-1H-indole-5-carbonitrile is prepared as a colorless crystalline solid, m.p. 77-79 ° C.
(d) In a similar manner to that described in Reference Example (a), but using indole-3-carbonitrile and (3-bromopropoxy) -tert-butyldimethylsilane, 1- [3- (tert-butyldimethylsilyloxy) propyl] -1H-indol was prepared -3-Carbonitrile as a clear colorless oil, TLC: Rp = 0.6 (dichloromethane). @ 1 H-NMR (CDCl3)<sub>3</sub>): δ 7.70 (1H, d, J = 8Hz); 7.56 (1 H, s); 7.39 (1H, d, J = 8Hz); 7.27 (1 H, t,
J = 8Hz); 7.22 (1H, t, J = 8Hz); 4.25 (2H, t, J = 6Hz); 3.49 (2H, t, J = 6Hz); 1.95 (2H, quintet, J = 6 Hz); 0.87 (9 H, s); 0.00 (6 H, s).
(e) In a similar manner to that described in Reference Example 2 (a), but using 5-methoxy-1H-indole-3-carbonitrile [Reference Example 1 (a)] and (3-bromopropoxy) -tert-butyldimethylsilane, 1- [3- (tert-Butyldimethylsilyloxy) propyl] -5-methoxy-1H-indole-3-carbonitrile was prepared as a clear colorless oil. <sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 8.18 (1H, s); 7.55 (1 H, d, J = 9 Hz); 7.09 (1 H, d, J = 2 Hz); 6.95 (1H, dd, J = 9 and 2 Hz); 4.27 (2H, t, J = 6Hz); 3.82 (3 H, s); 3.53 (2H, t, J = 6Hz); 1.95 (2H, quintet, J = 6 Hz); 0.87 (9 H, s); 0.00 (6 H, s).
(f) In a similar manner to that described in Reference Example 2 (a), but using indole-3-carbonitrile and (2-bromoethoxy) tert-butyldimethylsilane, 1- [2- (tert-butyldimethylsilyloxy) ethyl] -1H- Indole-3-carbonitrile, in the form of a clear, colorless oil. TLC: R f = 0.65 (dichloromethane).
230 (g) In a similar manner to that described in Reference Example (a), but using 5-methoxy-1H-indole-3-carbonitrile [Reference Example 1 (a)] and benzyl bromide, 1-benzyl-5-methoxy- 1H-Indole-3-carbonitrile, as a brown solid. Mass Spectrum: 263.22 (MH +)<sup>+</sup>). TLC: Rp = 0.8 (dichloromethane / methanol: 1). (h) In a similar manner to that described in Reference Example 2 (a), but using 5-methoxy-1H-indole-3-carbonitrile [Reference Example 1 (a)] and 2-bromoethoxydimethyl-tert-butylsilane, prepare
1- [2- (tert-Butyldimethylsilyloxy) ethyl] -5-methoxy-1H-indole-3-carbonitrile as a pale yellow solid. Mass Spec: 331.23 (MH +)<sup>+</sup>). TLC: R f = 0.6 (pentane / ethyl acetate 8: 2).
(i) In a similar manner to that described in Reference Example (a), but using 1 H -pyrrole-3-carbonitrile [prepared according to the procedure described in Tetrahedron Lett., 52, 5337-5340 (1972)], 1-methyl was prepared. 1 H-pyrrole-3-carbonitrile as a brown oil. Mass Spectrum: 107 (MH +);<sup>+</sup>) . <sup>X</sup>1 H-NMR (CDCl 3): δ 7.09 (1H, m);
6.60 (1 H, m); 6.40 (1 H, m); 3.68 (3 H, s).
(j) In a similar manner to that described in Reference Example (a), but using 1 H-pyrrole-2-carbonitrile, 1-methyl-1 H -pyrrole-2-carbonitrile was prepared as a colorless liquid. Mass Spectrum: 106 (MH +);<sup>+</sup>) . <sup>X</sup>1 H-NMR (CDCl 3): δ 6.80 (1H, m); 6.67 (1 H, m); 6.15 (1 H, m); 3.79 (3 H, s).
(k) In a similar manner to that described in Reference Example (a), but using 2-phenyl-1H-pyrrole-4-carbonitrile [prepared according to the procedure described in Synth. Commun., 25 (6), 795-802 (1995)], 1-methyl-2-phenyl-1H-pyrrole-4-carbonitrile was prepared as a cream colored solid, m.p. 50-51 ° C. Mass Spectrum: 183 (MH +);<sup>+</sup>) .
(1) In a similar manner to that described in Reference Example (a), but using 4-methoxy-2- (5-methoxy-1H-indol-3-yl) -1- (to 2,3-toluene-4-sulfonyl) -ΙΗ pyrrolo [2,3-b] pyridine (Reference Example
39) prepare 4-methoxy-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine in in the form of a dark oil. HPLC (Method A): Rt<sub>T</sub> = 9.49 minutes. TLC: Rf<sub>F</sub> 0.50 (pentane / ethyl acetate 1: 1).
(m) In a similar manner to that described in Reference Example 2 (a), but using 2- (5-methoxy-1H-indol-3-yl) -4-phenyl-1- (toluene-4-sulfonyl) -1H- -pyrrolo [2,3-b] pyridine (Reference Example 12 (g)) was prepared 2- (5-methoxy-1-methyl-1H-indol-3-yl) -4-phenyl-1- (toluene-4) (sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a brown solid. <sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]; δ 8.39 (1H, d, J = 4.4Hz); 7.71 (2H, d, J = 7.2Hz); 7.63 (3 H, m); 7.52 (2H, t, J = 8.5Hz); 7.44 (3 H, m); 7.29 (2H, d, J = 7.2Hz); 6.94 (1 H, s); 6.86 (1H, d, J = 8.5Hz); 6.82 (1 H, s); 3.86 (3 H, s); 3.71 (3 H, s); 2.29 (3 H, s).
Reference Example 3 (a) 6- {1- [3- (tert-Butyldimethylsilyloxy) propyl] -1H-indol-3-yl} -
-5H-pyrrolo [2,3-b] pyrazine
In a similar manner to that described in Reference Example 1 (a), but using 1- [3- (tert-butyldimethylsilyloxy) propyl] -1H 2 (d)], the compounds were prepared. <sup>1</sup>H-NMR
-indole-3-carbonitrile title compound in
12.2 (1 H,
8.10, an example form solid broad
7.59 (1H each, d, J = 7.8 Hz);
8.09 (1 H, d, J = 2.7)
7,29,
1H, t, J = 7.1 (2H, t,
J = 6.0 Hz); 2.03 (2H, quintet, J (6H, s)) Mass spectrum: 407 (MH +)<sup>+</sup>) .
6.2 Hz);
0.89 (9H,
with) ; 0.00 (b) In a similar manner to that described in Reference Example 1 (a), but using 1- [3- (tert-butyldimethylsilyloxy) propyl] -5-methoxy-1 H -indole-3-carbonitrile [Reference Example 2 (e)], prepare 6- {1- [3- (tert-butyldimethylsilyloxy) propyl] -5-methoxy-1H-232
-indol-3-yl} -5H-pyrrolo [2,3-b] pyrazine as a solid. TLC:
<td>R<sub>F</sub> =</td><td> 0,4</td><td colspan="3">(ethyl acetate / pentane 1</td><td> : 1) . <sup>1</sup>@ 1 H-NMR .delta<sub>3</sub>) <sub>2</sub>SO]: δ</td><td> 8,27</td><td>(1 H,</td>
<td>d, J</td><td> = 4</td><td>Hz); 8.08</td><td>(2H,</td><td>m);</td><td>7.50 (2 H, m); 6.96 (1 H,</td><td>with) ;</td><td> 6, 91</td>
<td>(1 H,</td><td>dd,</td><td>J = 6 and 2</td><td>Hz);</td><td> 4,29</td><td>(2H, t, J = 6Hz); 3, 89</td><td>(3H,</td><td>with) ;</td>
<td>3.61 with) .</td><td>(2H,</td><td>t, J = 6</td><td>Hz);</td><td> 2,00</td><td>(2H, m); 0.89 (9 H, s);</td><td> 0,03</td><td>(6H,</td>
<td>(C)</td><td colspan="3">In a similar way,</td><td>how</td><td>is described in the reference</td><td colspan="2">Example</td>
1 (a), but using 1- [2- (tert-butyldimethylsilyloxy) ethyl] -1H-indole-3-carbonitrile [Reference Example 2 (f)], 6- {1- [3- (tert-butyldimethylsilyloxy) is prepared. 1-Ethyl] -1H-indol-3-yl} -5H-pyrrolo [2,3-b] pyrazine as a solid. TLC: R f = 0.3 (ethyl acetate / pentane 1: 1). Mass Spectrum: 393 (MH +)<sup>+</sup>) .
(d) In a similar manner to that described in Reference Example 1 (a), but using 1- [2- (tert-butyldimethylsilyloxy) ethyl] -5-methoxy-1H-indole-3-carbonitrile [Reference Example 2 (h) ], 6- {1- [2- (tert-Butyldimethylsilyloxy) ethyl] -5-methoxy-1H-indol-3-yl} -5H-pyrrolo [2,3-b] pyrazine was prepared as a brown solid. TLC: R f = 0.4 (dichloromethane / methanol 19: 1). Mass Spectrum: 423 (MH +);<sup>+</sup>) .
Reference example 4
- [3- (5H-Pyrolo [2,3-b] pyrazin-6-yl) indol-1-yl] propyl bromide
To a solution of 3- [3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -indol-1-yl] -propan-1-ol [Example 2 (a)] and 1.59 g of carbon tetrachloride in 40 ml of dichloromethane a solution of 1.1 g of triphenylphosphine in 10 ml of dichloromethane is added at room temperature over 2 minutes. The reaction mixture was stirred for 3 hours at room temperature, then allowed to stand for 18 hours and then evaporated to give the title compound which was used without further purification.
Reference example 5
233
Indolizine-l-carbonitrile
A mixture of 5 g of 2-pyridylacetonitrile and 4.42 g of chloroacetaldehyde (50% by weight solution in water) is refluxed in 25 ml of 1,4-dioxane for 5.5 hours. The reaction mixture was allowed to cool to room temperature and then evaporated. The residue was partitioned between 100 mL of ethyl acetate and 100 mL of 1 M hydrochloric acid. The aqueous layer was extracted twice with 100 mL of ethyl acetate. The combined organic phases are washed with 50 ml of brine, then dried over magnesium sulphate and evaporated. The residue was purified by silica gel column chromatography eluting with dichloromethane to give 1.83 g of the title compound as a colorless solid, mp 53-54 ° C. Mass Spectrum: 143 (MH +);<sup>+</sup>) .
Reference example 6
3-methylindolizin-l-carbonitrile
A solution of 36 ml of propionaldehyde in 200 ml of diethyl ether and 1.7 ml of 1,4-dioxane is treated dropwise over 2 hours at 5 ° C in a nitrogen atmosphere with 24.7 ml of bromine while maintaining the temperature at 5 ° C. After the addition was complete, the reaction mixture was stirred for an additional 30 minutes and then washed carefully with 100 mL of saturated aqueous sodium bicarbonate. The organic phase is dried over sodium sulphate, evaporated under vacuum at 10 ° C and then immediately treated with a solution of 8.36 g of 2-pyridylacetonitrile in 50 ml of acetone. The mixture was heated to reflux for 6 hours under nitrogen, then allowed to stand at room temperature overnight and evaporated. The residue was partitioned between 500 mL of ethyl acetate and 100 mL of a 1 M hydrochloric acid solution. The organic layer was washed with 100 mL of brine and then evaporated. The residue is purified by flash column chromatography on silica gel, eluting with ethyl acetate / pentane (1: 4, v / v) and then triturated with diethyl ether to give 4.0 g of the title compound.
234 as a white solid, m.p. 98-100 ° C.
Mass Spectrum: 157 (MH +);<sup>+</sup>) .
Reference Example 7 Sodium 1-formylpiperidine-2-carboxylate
To a solution of 30 g piperidine-2-carboxylic acid in 230 ml formic acid was added dropwise 147 ml acetic anhydride. The ongoing exothermic reaction is controlled by cooling the reaction mixture in an ice / water bath. After stirring at room temperature for 24 hours, the reaction mixture is diluted with 20 ml of water and then evaporated in vacuo. The oil obtained is dissolved in a mixture of 50 ml of methanol and 500 ml of acetonitrile. 23 ml of 10 M sodium hydroxide solution are added and the reaction mixture is stirred for 8 hours. The resulting precipitate was filtered off, washed with acetonitrile and ethyl acetate and dried in a vacuum oven to give the title compound as a white solid, which was used immediately without further purification.
Reference example 8
5,6,7,8-Tetrahydroindolizine-1-carbonitrile
2.31 g of p-toluenesulfonyl chloride was added to a solution of 2.0 g of sodium 1-formylpiperidine-2-carboxylate (Reference Example 7) in 50 ml of dichloromethane at room temperature under a nitrogen atmosphere. After stirring for 10 minutes, the mixture was treated dropwise with 0.88 ml of acrylonitrile and 1.5 ml of triethylamine and stirring was continued for a further 1 hour. A second portion of 1.0 ml triethylamine is then added. The reaction mixture was stirred for 18 hours and the dichloromethane was evaporated in vacuo. The residue is taken up in 50 ml of water and extracted with 200 ml of ethyl acetate. The combined organic extracts were evaporated in vacuo and the residue was purified by silica gel flash column chromatography eluting with ethyl acetate / pentane (1: 4, v / v) to give the title compound as an orange oil (1.38 g). Mass spectrum:
235
147 (ΜΗ<sup>+</sup>) . <sup>X</sup>1 H-NMR (CDCl 3)?<sub>3</sub>): δ 6.48 (1H, d, J = 3.1Hz); 6.36 (1H, d, J = 3.1Hz); 3.91 (2H, t, J = 6.0 Hz); 2.89 (2H, t, J = 6.0)
Hz); 1.98 (2 H, m); 1.88 (2 H, m).
Reference Example 9 (a) 1- (Toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine
To a solution of 25 g of 7-azaindole, 44.5 g of p-toluenesulfonyl chloride and a catalytic amount of tetrabutylammonium sulfate in 300 ml of dry toluene is added 160 g of sodium hydroxide dissolved in 500 ml of water. The biphasic solution is stirred for 3 hours at room temperature and then extracted twice with 100 ml of toluene. The combined extracts were dried over magnesium sulphate and then evaporated in vacuo. The solid obtained was triturated with diethyl ether and then dried at 60 ° C under vacuum to give 39.74 g of the title compound as a light yellow solid, mp 136-138 ° C.
(b) By a similar procedure to that described in Reference Example (a), but using 4-nitro-1H-pyrrolo [2,3-b] pyridine [prepared according to the procedure described in A. Ippolito et al., J. Med. Chem., 25 (10), 1258-1261 (1982)], 4-nitro-1- (1-toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine was prepared as an orange solid with m.p. mp 145-46 ° C. HPLC (Method A): Rt<sub>T</sub> = 10.8 minutes.
(c) In a similar manner to that described in Reference Example 9 (a), but using 4-chloro-1H-pyrrolo [2,3-b] pyridine (Reference Example 64), 4-chloro-1- (toluene- 4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a white solid. Mass Spectrum: 307 (MH +);<sup>+</sup>) . <sup>X</sup>1 H-NMR (CDCl 3)?<sub>3</sub>): δ 8.3 (d, 1H), 8.05 (d, 2H), 7.8 (d, 1H), 7.3 (d, 2H), 7.2 (d, 1H), 6, Δ (d, 1H), 2.4 (s, 3H).
(d) By a similar procedure to that described in Reference Example 9 (a), but using 5-bromo-1H-pyrrolo [2,3-b] pyridine, the following were prepared:
5-Bromo-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine in the form of
236 138 DEG-140 DEG.
(e) In a similar manner to that described in Reference Example 9 (a), but using 4-phenyl-1H-pyrrolo [2,3-b] pyrazine (Reference Example 42), 4-phenyl-1- (toluene) was prepared. -4-sulfonyl) -1H-pyrrolo [2,3-b] pyrazine as a white solid, which is used
<td>without another</td><td>cleaning.</td><td>@ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]</td><td>: δ 8.44 (1H,</td><td>d.</td>
<td>J = 4.5 (2H z); 8,</td><td>04 (2H, d)</td><td>J = 8.2 Hz); 7.98</td><td>(1H, d, J = 4.5)</td><td>Hz);</td>
<td>7.69 (2 H, d, J)</td><td>= 6.8 Hz);</td><td>7.57 (tt, J = 6.2)</td><td>and 1.8 Hz); 7.51</td><td>(1 H,</td>
tt, J = 6.8 and 1.8 Hz); 7.44 (2H, d, J = 8.2Hz); 7.42 (1 H, d,
J = 4.5 Hz); 6.92 (1H, d, J = 4.5Hz).
Reference example 10
2-Iodo-l- (toluene-4-sulfonyl) -lH-pyrrolo [2,3-b] pyridine
A solution of 54.4 g of 1- (toluene-4-sulfonyl) -4-pyrrolo [2,3-b] pyridine [Reference Example 9 (a)] in 1200 ml of dry tetrahydrofuran is cooled to -78 ° C and reacted for 20 minutes with 92 ml of a 2.5 M solution of butyllithium in hexane. The solution is kept at -78 ° C for 30 minutes, then a solution of 101 g of iodine in 600 ml of tetrahydrofuran is added until the mixture is colored after yoga (about 300 ml). The mixture was allowed to warm slowly to room temperature and the solvent was evaporated in vacuo. The residue is partitioned between 1000 ml of ethyl acetate and 500 ml of water and the aqueous phase is extracted twice with 500 ml of ethyl acetate. The organic extracts were combined, dried over sodium sulfate and evaporated in vacuo to give a yellow solid, which was triturated with diethyl ether to give 79.6 g of the title compound as a light yellow solid, mp 105-107 ° C. C. Mass Spectrum: 399 (MH +);<sup>+</sup>) .
Reference Example 11 (a) 3-Bromo-5-methoxyindole-1-carboxylic acid tert-butyl ester
A solution of 10 g of 5-methoxyindole in 150 ml of dry dimethylformamide is treated dropwise with 4 ml of bromine at room temperature, whereby
237 ensure that the temperature does not exceed 30 ° C. The mixture is immediately treated with 25 ml of triethylamine and 0.5 g of 4-dimethylaminopyridine, then a solution of 18 g of di-tert-butyl dicarbonate in 80 ml of dry dimethylformamide is added and stirring is continued for another 4 hours. The reaction mixture was evaporated and the residue was partitioned between 250 mL of ethyl acetate and 200 mL of water. The aqueous layer was extracted with 100 mL of ethyl acetate. The combined organic phases are washed with 100 ml of water, then 100 ml of brine, then dried over magnesium sulphate and evaporated. The residue was purified by silica gel flash column chromatography eluting with pentane: ethyl acetate (19: 1, v / v) to give 23.4 g of a colorless solid, mp 111-112 ° C.
(b) By a similar procedure to that described in Reference Example 11 (a), but using 5-cyanoindole, 3-bromo-5-cyanoindole-1-carboxylic acid tert-butyl ester was prepared as a gray solid, m.p. 174 ° C. Mass Spectrum: 322 (MH +);<sup>+</sup>) .
(c) Following a similar procedure to that described in Reference Example 11 (a), but using 5,6-dimethoxyindole, 3-bromo-5,6-dimethoxyindole-1-carboxylic acid tert-butyl ester was prepared as a violet solid. TLC: R f = 0.6 (pentane / ethyl acetate 19: 1).
(d) In a similar manner to that described in Reference Example 11 (a), but using 5-benzyloxy-6-methoxyindole [prepared according to the procedure described by JD Bengni and RL Minnis, Heterocycles, 387, 2, (1965)] prepare the tert-butyl ester of the acid
5-benzyloxy-3-bromo-6-methoxyindole-1-carboxylic acid as a colorless solid. Mass Spectrum: 433 (MH +);<sup>+</sup>). HPLC (Method A):. Ρψ = 13.99 minutes.
(e) In a similar manner to that described in Reference Example 11 (a), but using 5-aminoindole and an excess of di-tert-butyl dicarbonate, 3-bromo-5-tert-butoxycarbonylaminoindole-1-carboxylic acid tert-butyl ester was prepared in form of orange
238 oil. Mass Spectrum: 412 (MH +);<sup>+</sup>). TLC: R f = 0.8 (pentane / ethyl acetate 9: 1).
(f) Following a similar procedure to that described in Reference Example 11 (a), but using 1 H-indole-6-carboxylic acid methyl ester [Reference Example 31], 3-bromoindole-1-tert-butyl ester 6-methyl ester was prepared. 6-dicarboxylic acid as a violet solid, m.p. 117-119 ° C. Mass Spectrum: 355 (MH +);<sup>+</sup>) .
Reference Example 12 (a) 2- (5-Methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine
A stirred solution of 50 g of 3-bromo-5-methoxyindole-1-carboxylic acid tert-butyl ester [Reference Example 11 (a)] in 800 ml of tetrahydrofuran is treated with 49.5 ml of tributylborate under nitrogen, then cooled to -100 ° C. and reacted with 94 mL of a 2.5 M solution of n-butyllithium in hexane while maintaining the temperature below -90 ° C. Once the addition is complete, the mixture is allowed to warm slowly to room temperature over 1 hour and quenched by the addition of 10 g of ice. The organics were evaporated under reduced pressure and the residue was partitioned between 500 mL ethyl acetate and 400 mL water. The organic layer was dried over magnesium sulfate and then evaporated. The boric acid obtained, which is in the form of 28 g of a beige solid, is dissolved in 600 ml of dimethylformamide and the solution is treated with 38.3 g of 2-iodo-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3] -b] pyridine [reference example 10], then with 200 ml of a saturated aqueous solution of sodium bicarbonate and then with tetrakis (triphenylphosphine) palladium (0). The mixture was heated at reflux for hours, then cooled to room temperature and the dimethylformamide was evaporated. The residue is partitioned between 400 ml of water and 500 ml of ethyl acetate and the aqueous phase is extracted twice with 300 ml of ethyl acetate. The combined organic phases are dried over sodium sulphate and then evaporated. Remaining brown
239 The gum was triturated with ethyl acetate to give 27 g of the title compound as a light green solid. Mass Spectrum: 418.43 (MH +)<sup>+</sup>) .
(b) In a similar manner to that described in Reference Example 12 (a), but using 3-bromo-5-cyano-indole-1-carboxylic acid tert-butyl ester [Reference Example 11 (b)], 3 - [ 1- (toluene-4-sulfonyl) -177-pyrrolo [2,3-b] pyrid-2-yl] -177-indole-5-carbonitrile as a colorless solid, m.p. 209-214 ° C. Mass Spectrum: 413 (MH +)<sup>+</sup>) .
(c) By a similar procedure to that described in Reference Example 12 (a) but using 3-bromo-5,6-dimethoxyindole-1-carboxylic acid tert-butyl ester [Reference Example 11 (c)],
2- (5,6-Dimethoxy-177-indol-3-yl) -1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3- b] pyridine as a brown solid. Mass Spectrum: 446 (MH +);<sup>+</sup>) .
(d) In a similar manner to that described in the reference example
12 (a), but using 5-benzyloxy-3-bromo-6-methoxyindole-1-carboxylic acid tert-butyl ester [Reference Example 11 (d)], 2- (5-benzyloxy-6-methoxy-177-) is prepared. indol-3-yl) -1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3- b] pyridine as a colorless solid. Mass Spectrum: MH + = 524;<sup>+</sup>). HPLC (method A):
Rp = 10.09 minutes.
(e) In a similar manner to that described in the reference example
12 (a), but using 3-bromo-5-tert-butoxycarbonylaminoindole-1-carboxylic acid tert-butyl ester [Reference Example
11 (e)], {3- [1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3- b] pyrid-2-yl] -1 H -indol-5-y tert -butyl ester prepared 1} carbamate as a brown solid. Mass Spectrum: MH + = 503;<sup>+</sup>). TLC:
= 0.62 (pentane / ethyl acetate 1: 1).
(f) In a similar manner to that described in Reference Example 12 (a), but using 6-methyl ester 1-tert-butyl ester
240
3-bromoindole-1,6-dicarboxylic acid [Reference Example 11 (f)], 3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] methyl ester is prepared -1H-indole-6-carboxylic acid as a light yellow solid, m.p. 214-216 ° C. Mass Spectrum: 446 (MH +);<sup>+</sup>) .
(g) In a similar manner to that described in Reference Example 12 (a), but using 2-iodo-4-phenyl-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [reference] Example 62 (d)]: 2- (5-methoxy-1H-indol-3-yl) -4-phenyl-1- (toluene-4-sulfonyl) -1H-pyrrolo-
- [2,3-b] pyridine as a white solid. HPLC (Method A): R p = 11.63 minutes. Mass Spectrum: 494 (MH +);<sup>+</sup>) .
(h) In a similar manner to that described in Reference Example 12 (a), but using 4-chloro-2-iodo-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [ Reference Example 62 (b)] was prepared
4-Chloro-2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a white solid. Mass Spectrum: 452 (MH +);<sup>+</sup>) . <sup>X</sup>1 H-NMR (CDCl 3)?<sub>3</sub>δ: 8.4 (d, 1H), 7.6 (d, 2H), 7.5 (s, 1H), 7.35 (d, 1H), 7.2 (d, 2H), 6, 9 (m, 2H); 6.7 (s. 1H);
3.8 (s, 3H); 2.3 (s, 3H).
(i) In a similar manner to that described in Reference Example 12 (a), but using 2-iodo-5-phenyl-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [reference] Example 62 (c)]: 2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -5-phenyl-1H-pyrrolidine-
- [2,3-b] pyridine. Mass Spectrum: 494 (MH +);<sup>+</sup>) .
(j) In a similar manner to that described in Reference Example (a), but using 4-chloro-2-iodo-1- (p-toluenesulfonyl) -1 H -pyrrolo [2,3- b] pyridine [Reference Example 62 ( b)] and 4-tert-butylphenylboronic acid, 4-chloro-2- (4-tert-butylphenyl) -1- (p-toluenesulfonyl) -1H-pyrrolo [2,3-b] pyridine was prepared as a white solid. Mass Spec .: 439 (MH +)<sup>+</sup>). TLC Re = 0.78 (ethyl acetate / heptane, 1: 1).
241
Reference Example 13 (a) {5-Methoxy-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -indol-1-yl} -acetic acid ethyl ester
A solution of 6.6 g of 2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 12 (a)] in 100 ml of dimethylformamide is reacted with 700 mg of sodium hydride (60% dispersion in mineral oil) under a nitrogen atmosphere. After stirring at room temperature for 30 minutes, the mixture was treated dropwise with ethyl chloroacetate (2.0 mL, 23.75 mmol) and stirring was continued for another 4 hours. The reaction mixture was evaporated and the residue was partitioned between ethyl acetate and water. The organic phases were washed with brine, then dried over sodium sulfate and evaporated to give 5.77 g of the title compound as a yellow solid. Mass Spectrum: MH + = 504;<sup>+</sup>). HPLC (method A):
R p = 11.88 minutes.
(b) In a similar manner to that described in Reference Example 13 (a), but using methyl iodide, 2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene- 4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a yellow solid, m.p. 103-105 ° C. Mass Spectrum: 432 (MH +);<sup>+</sup>) .
(c) In a similar manner to that described in Reference Example 13 (a), but using 3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridin-2-yl] -1H of indole-5-carbonitrile [Reference Example 12 (b)] and methyl iodide, 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2- yl] -1H-indole-5-carbonitrile as a colorless solid, m.p. 189-191 ° C. Mass Spectrum: 427 (MH +);<sup>+</sup>) .
(d) In a similar manner to that described in Reference Example 13 (a), but using 2- (5,6-dimethoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 12 (c)] and methyl iodide were prepared 2- (5,6-dimethoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-) sulfonyl) -1H-pyrrolo [2,3-b] pyridine in brown form
242 solid. Mass Spectrum: 462 (MH +);<sup>+</sup>) .
(e) In a similar manner to that described in Reference Example 13 (a), but using 2- (5-benzyloxy-6-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H -pyrrolo [2,3-b] pyridine [Reference Example 12 (d)] and methyl iodide, 2- (5-benzyloxy-6-methoxy-1-methyl-1H-indol-3-yl) -1- ( toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a colorless solid. Mass Spectrum: 538 (MH +)<sup>+</sup>). HPLC (Method A): Rt<sub>T</sub> = 11.57 minutes.
(f) In a similar manner to that described in the reference example
13 (a) but using {3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yl} tert-butyl ester carbamic acid [Reference Example 12 (e)] and methyl iodide, [1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-tert-butyl ester] was prepared. 1-yl] -1 H -indol-5-yl} carbamate as a brown solid. Mass Spectrum: 517 (MH +)<sup>+</sup>). TLC: R f = 0.7 (pentane / ethyl acetate 1: 1).
(g) In a similar manner to that described in the reference example
13 (a) but using 3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-6-carboxylic acid methyl ester [Reference Example 12 (f)] and methyl iodide, methyl acid ester is prepared. 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-6-carboxylic acid as a brown solid. Mass Spectrum: 460 (MH +);<sup>+</sup>). TLC: R f = 0.6 (pentane / ethyl acetate
1:1).
(h) In a similar manner to that described in Reference Example 13 (a), but using 2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2] 3-b] pyridine-4-carbonitrile. (Reference Example 100) 2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine-4 was prepared. -carbonitrile as a yellow oil. TLC: R f = 0.40 (ethyl acetate / heptane 1: 1). Mass Spectrum: 457 (MH +)<sup>+</sup>) .
243 (i) By a similar procedure to that described in Reference Example 13 (a), but using 4-chloro-2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1 H- -pyrrolo [2,3-b] pyridine [reference example (h)] and methyl iodide, prepare 4-chloro-2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene) -4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as an off-white solid. Mass Spectrum: 466 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR (CDCl 3)?<sub>3</sub>): δ 8.35 (d, 1H); 7.56 (d, 2H); 7.39 (s, 1H); 7.16-7.3 (m, 2H), 7.05 (d, 2H), 6.95-7.0 (m, 2H) 6.6 (s, 1H) 3.9 (s, 3H)
3.8 (s, 3H); 2.3 (s, 3H).
(j) In a similar manner to that described in Reference Example 13 (a), but using 2- (5-methoxy-1H-indol-3-yl) -5-phenyl-1- (toluene-4-sulfonyl) -1H -pyrrolo [2,3-b] pyridine [reference example 12 (i)] and methyl iodide, 2- (5-methoxy-1-methyl-1H-indole-
3-yl) -5-phenyl-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a yellow solid, m.p. 181-183 ° C. Mass Spectrum: MH + 508;<sup>+</sup>) .
Reference Example 14 (a) 1-Methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-ol
To a solution of 24.5 g of 2- (5-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example] (b)] in 500 ml of dichloromethane at 0 ° C under a nitrogen atmosphere was added 60 ml of a 1.0 M solution of boron tribromide in dichloromethane and the mixture was stirred for 1 hour at 0 ° C. The reaction mixture was allowed to warm slowly to room temperature and stirring was continued for 12 hours. 250 ml of 1 M sodium carbonate solution are added to the mixture and stirring is continued for a further 3 hours. The precipitated solid was filtered off, washed with 100 ml of dichloromethane and dried to give 18.75 g of the title compound as a colorless solid, mp 256-257 ° C. Mass Spectrum: 418 (MH +)<sup>+</sup>) .
244 (b) In a similar manner to that described in Reference Example 14 (a), but using 2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2] 3-b] pyridine [Reference Example 12 (a)], 3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole was prepared -5-ol as a beige solid, m.p. 188-191 ° C. Mass Spectrum :. 403 (MH @ +)<sup>+</sup>).
Reference Example 15 (a) 2- (5-Allyloxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine
A solution of 2.1 g of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-ol [reference example 14 (a)] in 50 ml of dry dimethylformamide is reacted with 620 mg of potassium tert-butoxide at 0 ° C under nitrogen. After stirring for 10 minutes, the mixture is treated with 480 μL of allyl bromide and then allowed to warm slowly to room temperature. Stirring is continued for an additional 6 hours, then the reaction mixture is carefully poured into water and the aqueous phase is extracted thoroughly with ethyl acetate. The combined organic extracts were washed twice with 100 ml of brine, then dried over sodium sulfate and evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate / pentane (1: 1, v / v) to give the title compound as a yellow foam (1.2 g), mp 257-259 ° C. Mass Spectrum: 458 (MH +)<sup>+</sup>) .
(b) By a similar procedure to that described in Reference Example 15 (a) but using ethyl chloroacetate, ethyl {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] [2,3-d] -propyl ester was prepared. -b] pyrid-2-yl] -1H-indol-5-yloxy} acetic acid as a yellow solid. TLC: R f = 0.45 (ethyl acetate / pentane 1: 1). Mass Spectrum: MH + = 504;<sup>+</sup>) .
(c) By a similar procedure to that described in Reference Example 15 (a), but using ethyl 2-bromopropionate, the ethyl ester was prepared.
245 3- {1-Methyl-3- [1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3- b] pyrid-2-yl] -1 H -indol-5-yloxy} propionic acid as yellow solid. TLC: R f = 0.47 (ethyl acetate / pentane 1: 1). Mass Spectrum: MH + = 519;<sup>+</sup>) .
(d) By a similar procedure to that described in Reference Example '15 (a), but using ethyl 1-bromocyclobutanecarboxylate, 1- (1-methyl-3- [1- (toluene-4-sulfonyl) - 1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yloxy} cyclobutanecarboxylic acid as a colorless solid, m.p. 189-190 ° C. Mass Spectrum: 544 (MH +);<sup>+</sup>) .
(e) In a similar manner to that described in the reference example
15 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-ol [Example 7] and ethyl 1-bromocyclobutanecarboxylate, ethyl ester is prepared [1- [1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-yloxy] cyclobutanecarboxylic acid as a brown solid. TLC: Rf<sub>F</sub> = 0.23 (dichloromethane / methanol, 19: 1).
HPLC (Method A): Rt<sub>T</sub> = 7.71 minutes.
Reference example 16
3- {1-Methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yloxy} propane-1,2 diol
A solution of 45.7 mg of 2- (5-allyloxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [ Reference Example 15 (a)] in 10 ml of acetone was treated with a solution of 6 ml of 4-methylmorpholine-N-oxide in 1 ml of water. This mixture is then treated with 6 drops
A 2.5% (w / w) solution of osmium tetroxide in tert-butanol was stirred at room temperature for 12 hours. The reaction mixture was diluted with 75 mL of water and extracted thoroughly with ethyl acetate. The combined organic extracts were washed twice with 75 mL brine, then dried over magnesium sulfate and evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate to give 33 mg of the title compound as a white solid.
246 in the form of a colorless solid. TLC: R f = 0.25 (ethyl acetate).
Mass Spectrum: 492 (MH +);<sup>+</sup>) .
Reference example 17
3- {1-Methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yloxy} propan-1-ol and 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yloxy} propan-2 -o 1
A solution of 91 mg of 2- (5-allyloxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 15 (a) )] in 5 ml of dry tetrahydrofuran reacts with 1200 μΐ of a 1.0 M solution of borane / tetrahydrofuran complex in tetrahydrofuran. After stirring at room temperature for 7 hours, the reaction mixture was treated with 9 drops of ethanol, 4 drops of 5 N potassium hydroxide solution and 6 drops of hydrogen peroxide and stirring was continued for 12 hours during which time a white solid precipitated. The reaction mixture is diluted with 50 ml of water and the pH of the mixture is adjusted to 10 by the addition of 1 M potassium hydroxide solution and then the mixture is extracted thoroughly with ethyl acetate. The combined organic extracts were dried over sodium sulfate and then evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate / pentane (2: 1, v / v) to give 50 mg of 3- {1-methyl-3- [1- (toluene-4-sulfonyl) - 1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yloxy} propan-1-ol as a colorless solid [TLC: Rp = 0.15 (ethyl acetate); mass spectrum: 476 (MH +);<sup>+</sup>)] and 8 mg of 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yloxy } propan-2-ol as a colorless solid. [TLC: R f = 0.3 (ethyl acetate); mass spectrum: 476 (MH +);<sup>+</sup>) ] .
Reference Example 18 Trifluoromethanesulfonic acid 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yl ester
247
A suspension of 398 mg of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-ol [Reference Example 14 ( a)] in ml of dichloromethane is cooled to a temperature under nitrogen atmosphere
-78 DEG C. and treated with 0.15 ml of triethylamine and then with 1.7 g of N-phenyltrifluoromethanesulfonimide. The resulting mixture was allowed to warm slowly to room temperature, stirring was continued for an additional 12 hours, and then 20 mL of saturated aqueous sodium bicarbonate was added. The organic phase is separated and the aqueous phase is extracted twice with 20 ml of dichloromethane. The combined organic phases are dried over sodium sulphate and then evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate: pentane (2: 3, v / v) to give the title compound as a colorless solid (380 mg). Mass Spectrum: 492 (MH +);<sup>+</sup>). HPLC (Method A): R t = 2.02 min.
(b) In a similar manner to that described in Reference Example 18 (a), but using 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -1H-indol-5-ol [Example 7], 2- (1-methyl-5-trifluoromethanesulfonyloxyindol-3-yl) -1H-pyrrolo [2,3-b] pyrazine was prepared as a red solid. HPLC (Method A): Rt<sub>T</sub> = 8.12 minutes. <sup>1</sup>H-NMR
<td>[(CD<sub>3</sub>)<sub>2</sub>SO]:</td><td colspan="2">δ 12.30 (1H,</td><td>with) ;</td><td> 8,32</td><td>(1 H, s); 8.27</td><td>(1 H,</td><td>d.</td>
<td>J = 3.5Hz)</td><td> ; 8,23</td><td>(1 H,</td><td>with) ;</td><td> 7,97</td><td>(1 H, s); 7.76</td><td>(1 H,</td><td>d.</td>
<td>J = 8.6 Hz)</td><td> ; 7,08 (</td><td>ΤΗ, s);</td><td> 3,96</td><td>(4H, s)</td><td> •</td><td></td><td></td>
<td>reference</td><td>example</td><td> 19</td><td></td><td></td><td></td><td></td><td></td>
(a) 1-Methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-5-carboxylic acid methyl ester
A solution of 300 mg of trifluoromethanesulfonic acid 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yl ester [Reference Example] 18 (a)] in a mixture of 10 ml of dry dimethylformamide, 6 ml of methanol and 2 ml of triethylamine is treated with mg of palladium acetate and 1,3-bis (diphenylphosphino) propane and the mixture is stirred for 30 minutes at room temperature. Through the septum
248 Carbon monoxide was added to the reaction vessel at a constant rate and the mixture was heated to 90 ° C until the starting material disappeared by TLC (ethyl acetate / pentane 2: 3). The mixture was then evaporated in vacuo and the residue partitioned between dichloromethane and water. The organic phase is washed with saturated lithium chloride solution, then dried over sodium sulphate and evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate / pentane (2: 3, v / v) to give the title compound as a colorless solid (200 mg). Mass Spectrum: 460 (MH +);<sup>+</sup>). HPLC (Method A): Rf = 10.23 min.
(b) In a similar manner to that described in Reference Example 19 (a), but using 2- (1-methyl-5-trifluoromethanesulfonyloxyindole-
3-yl) -1H-pyrrolo [2,3-b] pyrazine [Reference Example 18 (b)] was prepared 1-methyl-3- (5H-pyrrolo [2,3-b] pyrazin-6-yl) methyl ester 1 H -indole-5-carboxylic acid as a brown solid. Mass Spectrum: 307 (MH +);<sup>+</sup>). HPLC (Method A): Rt<sub>T</sub> = 6.64 minutes.
Reference example 20
2- [1-Methyl-5- (1-trimethylstananyl-1H-tetrazol-5-yl) -1H-indol-3-yl] -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3- b] pyridine
A solution of 100 mg of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1 H -indole-5-carbonitrile [Reference Example] 13 (c)] in 10 ml of toluene is treated with 56 mg (0.28 mmol) of trimethyltin azide and then refluxed for 14 hours. The white precipitate was filtered off and washed with 10 mL of toluene and then dried to give 125 mg of the title compound as a colorless solid, mp 240-243 ° C (dec.). Mass Spectrum: 633 (MH +);<sup>+</sup>) .
Reference example 21
249
2- [l-methyl-5- (l-methyl-lH-tetrazol-5-yl) -lH-indol-3-yl] -1- (toluene-4-sulfonyl) -lH-pyrrolo [2,3- b] pyridine and 2- [1-methyl-5- (2-methyl-2H-tetrazol-5-yl) -1H-indol-3-yl] -1- (toluene-4-sulfonyl) -1H-pyrrolo [ 2,3-b] pyridine
2.5 ml of methyl iodide is added to a solution of 620 mg of 2- [1-methyl-5- (1-trimethylstananyl-1H-tetrazol-5-yl) -1H-indol-3-yl] -1- (toluene) at room temperature. -4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 20]. The mixture was then allowed to stir for 4 hours at room temperature, poured into water and then extracted with ethyl acetate. The combined organic extracts were washed with brine, then dried over magnesium sulphate and evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate / petroleum ether (1: 1, v / v) to give 191 mg of 2- [1-methyl-5- (1-methyl-1H-tetrazole-5-). yl) -1H-indol-3-yl] -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a colorless solid [Mass spectrum: 506
<td>(MNa <sup>+</sup> ) ; <sup>I</sup>H-NMR</td><td>[(CD<sub>3</sub>)<sub>2</sub>SO]:</td><td>δ 8.39</td><td>) (dd</td><td colspan="2">1H, J =</td><td>4,8 and 1,6</td><td>Hz);</td><td> 7,97</td>
<td>(m, 1 H); 7.96</td><td>(d, 1 H, J</td><td> = 4,0</td><td>Hz);</td><td> 7,90</td><td>(with,</td><td>1H); 7.80</td><td>(Dd,</td><td>1H,</td>
<td>J = 8.7 and 0.6</td><td>Hz); 7.70</td><td>(Dd,</td><td>1H,</td><td colspan="2">J = 8.7 and</td><td>1.8 Hz);</td><td> 7,56</td><td>(M,</td>
<td>2H); 7.30 (dd,</td><td>1 H, J =</td><td>7,7 a</td><td> 4,8</td><td>Hz);</td><td> 7,22</td><td>(m, 2H);</td><td> 6, 82</td><td>(with,</td>
<td>1H); 4.19 (s,</td><td>3H); 4.0</td><td>(s, 3H)</td><td> ; 2,</td><td colspan="2">24 (s, 3H)</td><td>] and 77 mg</td><td> 2— [1</td><td>-Me-</td>
ethyl 5- (2-methyl-2H-tetrazol-5-yl) -1H-indol-3-yl] -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as colorless solid, mp 215-218 ° C [Mass spectrum: 506 (MNa)]<sup>+</sup>) ] .
Reference example 22
1- {l-methyl-3- [1- (toluene-4-sulfonyl) -lH-pyrrolo [2,3-b] pyridin-2-yl] -lH-indol-5-yl} -ethanone
2.2 g of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridin-2-one] are gradually added to 110 ml of dry degassed dimethylformamide under a nitrogen atmosphere at room temperature. yl] trifluoromethanesulfonic acid 1H-indol-5-yl ester [Reference Example
250
18], 1.15 ml triethylamine, 2.87 ml n- butyl vinyl ether, 13 mg 1,3-bis (diphenylphosphino) propane, and 232 mg palladium acetate. The mixture was refluxed for 2 hours, then cooled to room temperature and added to 90 mL of 1 M hydrochloric acid. This mixture was extracted with 200 mL of dichloromethane. The organic extract was washed with saturated aqueous sodium bicarbonate and then brine, dried over magnesium sulfate and then evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate: pentane (2: 3, v / v) to give the title compound as a yellow solid (1.1 g), m.p. 177-178 ° C. Mass Spectrum: 444 (MH +);<sup>+</sup>) .
Reference Example 23 (a) 2- {5 - [(S) - (+) -2,2-Dimethyl-1,3-dioxolan-4-ylmethoxy] -1-methyl-1H-indol-3-yl} - 1- (toluene-4-sulfony1) pyrrolo [2,3-b] pyridine
A solution of 1.17 g of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-ol [Reference Example] 14 (a)] in 50 ml of dry dimethylformamide is treated with 1.1 g of cesium carbonate and 40 mg of tetrabutylammonium hydrogen sulfate. After stirring at room temperature for 30 minutes, the mixture is treated with 0.96 g of (E) - (+) - 2,2-dimethyl-1,3-dioxolan-4-ylmethyl-p-toluenesulfonate and then heated at 120 overnight. C. The reaction mixture was evaporated in vacuo and the residue was extracted twice between 100 mL of dichloromethane and 50 mL of water and the aqueous layers were extracted with 100 mL of dichloromethane. The combined organic phases are washed twice with 150 ml of brine, then dried over magnesium sulphate and evaporated. The residue was purified by flash column chromatography on silica gel eluting with dichloromethane / methanol (199: 1, v / v) to give 1.04 g of the title compound as a yellow oil. Mass Spectrum: 532 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR [(CD 3) 2 SO]: δ 1.30 (3H, s); 1.37 (3 H, s); 2.29 (3 H, s); 3.76 (1H, dd, J = 8.3 and
6.5 Hz); 3.90 (3 H, s); 3.94-3.98 (2H, m); 4.10 (1 * 4, dd)
J = 8.20 and 6.5 Hz); 4.41 (1 H, m); 6.74 (1 H, s); 6.91 (1 H, dd,
251
<td>J = 8.8</td><td colspan="2">and 2.3 Hz); 6.98 (1 H, d, J = 2.4)</td><td>Hz); 7.25</td><td>(2H,</td><td>d.</td>
<td>J = 7.9</td><td>Hz); 7.29 (1H, dd, J = 7.8 and</td><td> 4,9</td><td>Hz); 7.44</td><td>(1 H,</td><td>d.</td>
<td>J = 8.8</td><td>Hz); 7.56 (1H, d, J = 8.3Hz);</td><td> 7,63</td><td>(1 H, s); 7</td><td>, 81 i</td><td>(2H,</td>
<td>d, J =</td><td>8.0 Hz); 7.92 (1H, dd, J = 7.7 and</td><td> 1,6</td><td>Hz); 8.33.</td><td colspan="2">(1 H, dd,</td>
J = 4.9 and 1.7 Hz).
(b) Using a similar procedure to that described in Reference Example 23 (a), but using (S) - (-) - 2,2-dimethyl-1,3-dioxolan-4-ylmethyl-p-toluenesulfonate, 2 was prepared. - {5 - [(R) - (-) - 2,2-dimethyl ~ l, 3-dioxolan-4-ylmethoxy] -l-methyl-lH-indol-3-yl} -1- (toluene-4 sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a yellow oil. Mass Spectrum: 532 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR, [(CD<sub>3</sub>) <sub>2</sub>S0]: δ 1.33 (3H, s); 1.37 (3 H, s); 2.29 (3 H, s); 3.77 (1H, dd, J = 8.3 and 6.5 Hz); 3.88 (3 H, s); 3.97 - 3.99 (2H, m); 4.11 (1H, dd, J = 8.3 and 6.6 Hz); 4.41 (1 H,
<td>m)</td><td>T</td><td>6.74 (1 H, s); 6.</td><td> 94</td><td>(1H, dd, J = 8.8 and</td><td>2.3 Hz)</td><td>; 6.97 (1 H, d,</td>
<td>J</td><td> -</td><td colspan="2">2.3 · Hz); -7.25 (2 H,</td><td>d, J = 8.1 Hz); 7</td><td>29 (1 H,</td><td>dd, J = 7.8 and</td>
<td> 4,</td><td> 9</td><td>Hz); 7.44 (1 H,</td><td>d.</td><td>J = 8.8 Hz); 7.57</td><td>(2H, d,</td><td>J = 8.4 Hz);</td>
<td> 7,</td><td> 63</td><td>(1 H, s); 7.95</td><td>(1 H</td><td>, dd, J = 7.81 and 1</td><td>7 Hz);</td><td>8.33 (1 H, dd,</td>
<td>J</td><td> =</td><td>4.88 and 1.7 Hz).</td><td></td><td></td><td></td><td></td>
(c) In a similar manner to that described in Reference Example 23 (a), but using 2- (5-hydroxy-6-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 28 (a)], 2- {5 - [(S) - (+) - 2,2-dimethyl-1,3-dioxo was prepared. Lan-4-ylmethoxy] -6-methoxy-1-methyl-1H-indol-3-yl} -1- (toluuen-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine in the form of a cream colored solid. Mass Spectrum: 548 (MH +)<sup>+</sup>). HPLC (Method A): R t =
11.60 minutes.
(d) In a similar manner to that described in Reference Example 23 (a), but using 3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H indol-5-ol [Reference Example 14 (b)] and ethyl 1-bromocyclobutanecarboxylate were prepared 1- [1- (ethylcyclobutanecarboxylic acid ethyl ester) -3- [1- (toluene-4-sulfonyl) -1H] ethyl ester -pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yloxy} cyclobutanecarboxylic acid as a cream colored solid. weight
252
<td colspan="2">spectrum: 657</td><td>(MH<sup>+</sup>)</td><td> . <sup>X</sup>H ·</td><td>-NMR |</td><td>: (CD<sub>3</sub>)<sub>2</sub>SO]</td><td>: δ 8.35</td><td>(1 H,</td><td>dd,</td><td>J = 4.8 and</td>
<td> 1,6</td><td>Hz); 7.9</td><td>(2H,</td><td>m);</td><td> 7,48</td><td>(3H, m)</td><td> ; 7,28</td><td>(1 H,</td><td>dd,</td><td>J = 7, 7 and</td>
<td> 4,8</td><td>Hz); 7.24</td><td>(2H,</td><td>d.</td><td>J =</td><td>8.4 Hz);</td><td> • 6,71</td><td>(1 H,</td><td>dd,</td><td>J = 8.9 and</td>
<td> 2,4</td><td>Hz); 6.68</td><td>(1 H,</td><td>with) ;</td><td> 6, 64</td><td>(1 H, d,</td><td>J = 2.4</td><td>Hz);</td><td> 5, 12</td><td>(1 H, dd,</td>
<td>J =</td><td>8.8 and 8.8</td><td>Hz);</td><td>4, and:</td><td> 3 - 4,</td><td>03 (4H,</td><td>m); 3.66</td><td>(1 H,</td><td>dd,</td><td>J = 9.4 and</td>
<td> 9,4</td><td>Hz); 2, 64</td><td colspan="2"> - 1,82 (</td><td>13H,</td><td>m); 1.15</td><td>(3 H, t,</td><td>J =</td><td> 7,1</td><td>Hz); 0.94</td>
<td>(3H,</td><td>t, J = 7</td><td>1 Hz)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td>
Reference Example 24 (a) (S) -3- {1-Methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole 5-yloxy} -propane-l, 2-diol
A solution of 1.04 g of 2- {5 - [(R) - (-) - 2,2-dimethyl-1,3-dioxolan-4-ylmethoxy] -1-methyl-1H-indol-3-yl} -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 23 (b)] in 20 ml of methanol is treated with 20 ml of 1 M hydrochloric acid solution and then heated for 3 hours. hours at reflux. The reaction mixture was evaporated in vacuo and the residue purified by flash column chromatography on silica gel eluting with ethyl acetate: pentane (2: 1, v / v) to give the title compound as a clear oil (380 mg). TLC: R f = 0.2 (pentane / ethyl acetate 1: 2). Mass Spectrum: 492 (MH +);<sup>+</sup>) .
(b) In a similar manner to that described in Reference Example 24 (a), but using 2- {5 - [(S) - (+) -2,2-dimethyl-1,3-dioxolan-4-ylmethoxy] - l-methyl-l / H-indol-3-yl} -1- (toluene-4-sulfony1) -lH-pyrrolo
- [2,3-b] pyridine [Reference Example 23 (a)], yields (R) -3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2, b] 3-b] pyrid-2-yl] -1 H -indol-5-yloxy} propane-1,2-diol as a clear oil. weight
<td>Spec</td><td>: t rum</td><td>: 492 (MH @ +) <sup>+</sup> ) .</td><td> . <sup>X</sup>H-NMR</td><td>[(CD<sub>3</sub>)<sub>2</sub>SO]</td><td> : 8 8,33</td><td>(1 H,</td><td>dd,</td><td>J = 4</td><td>, 9 a</td>
<td> 1,7</td><td>Hz);</td><td>7.92 (1 H,</td><td>dd, J =</td><td>7.8 and 1</td><td>7 Hz);</td><td> 7, 62</td><td>(1 H,</td><td>with) ;</td><td> 7,56</td>
<td>(2H,</td><td>d.</td><td>J = 8.8 Hz</td><td> ); 7,45</td><td>(1 H, d,</td><td>J = 8.8</td><td>Hz);</td><td> 7,29</td><td>(1 H,</td><td>dd,</td>
<td>J =</td><td> 7,8</td><td>and 4.8 Hz)</td><td>; 7,25 i</td><td>: 2H</td><td>J = 8.1</td><td>Hz);</td><td> 6, 96</td><td>(1 H,</td><td>d.</td>
<td>J =</td><td> 2,3</td><td>Hz); 6.92 (</td><td>1 H, dd, J</td><td><sup>r</sup> = 8.8 and</td><td>2.3 Hz);</td><td> 6,75</td><td>(1 H,</td><td>with) ;</td><td> 4,93</td>
<td>(1 H,</td><td>with) ;</td><td>4.66 (1 H,</td><td>with); 5.13</td><td>(1 H, d,</td><td>J = 5.13</td><td>Hz);</td><td> 3,88</td><td>(3H,</td><td>with) ;</td>
253
3.80 (2Η, d, J = 5.9 Hz); 3.46 (2 H, s); 2.23 (3 H, s).
(c) In a similar manner to that described in Reference Example 23 (a), but using 2- {5 - [(S) - (+) - 2,2-dimethyl-1,3-dioxolan-4-ylmethoxy] - 6-Methoxy-1-methyl-1H-indol-3-yl} -1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3- b] pyridine [Reference Example 23 (c)] was prepared (A) -3- {6-Methoxy-1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole- 5-yloxy} propane-1,2-diol as a cream colored solid. Mass Spectrum: MH +, 522;<sup>+</sup>). HPLC (Method A): R f = 8.15 minutes.
Reference example 25
2- [5- (2-Methoxy-1-methylethoxy) -1-methyl-1H-indol-3-yl] -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine
A solution of 470 mg of triphenylphosphine and 350 μΐ of diisopropyldiazodicarboxylate in 15 ml of dry toluene is treated with 150 mg of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] 1 H-indol-5-ol [Reference Example 14 (a)] followed by 150 μΐ of 1-methoxy-2-propanol. The resulting mixture was heated at reflux for 5 hours and then cooled and evaporated. The residue was purified by flash column chromatography on silica gel, eluting with ethyl acetate: pentane (1: 1, v / v) to give 50 mg of the title compound as a clear oil. TLC: R f = 0.65 (pentane / ethyl acetate 1: 1). Mass Spectrum: 480 (MH +);<sup>+</sup>) .
Reference example 26
N-hydroxy-l-methyl-3- [1- (toluene-4-sulfonyl) -lH-pyrrolo [2,3-blpyrid-2-yl] -lH-indole-5-carboxamidine
A solution of 2.11 g of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-5-carbonitrile [Reference Example]
13 (c)] in 150 ml of ethanol is treated at room temperature with 1.72 g of hydroxylamine hydrochloride and 3.43 g of potassium carbonate.
254
The reaction mixture was heated to reflux for 15 hours under nitrogen and then filtered. The filtrate was evaporated to give 2.8 g of the title compound as a dark green solid. Mass Spectrum: 460 (MH +);<sup>+</sup>). HPLC (Method A): R p = 6.19 minutes.
L,
Reference example 27
2- [1-Methyl-5- (5-methyl-1,2,4-oxadiazol-3-yl) -1H-indol-3-yl] -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine, i
To a suspension of 0.7 g of N-hydroxy-1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridin-2-yl] -1H-indol-5- of carboxamidine [Reference Example 26] in 30 ml of toluene is added 0.467 g of acetic anhydride at room temperature under a nitrogen atmosphere. The reaction mixture was heated at reflux for 4.5 hours and then filtered. The filtrate was evaporated to give 0.32 g of the title compound as a dark red oil, which was used immediately in the next reaction without further purification.
Reference example 28
2- (5-Hydroxy-6-methoxy-l-methyl-lH-indol-3-yl) -1- (toluene-4-sulfonyl) -lH-pyrrolo [2,3-b] pyridine
A solution of 6.26 g of 2- (5-benzyloxy-6-methoxy-1-methyl-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 13 (e)] in 500 ml of acetonitrile was treated with 4.38 g of sodium iodide and then with 3.17 g of trimethylsilyl chloride. The mixture is stirred for 3 hours at 40 ° C, then treated with another portion of 4.38 g of sodium iodide and 3.17 ml of trimethylsilyl chloride. After stirring at 40 ° C for 12 hours, the reaction mixture was evaporated. The residue is treated with 200 ml of water and the mixture is extracted three times with 200 ml of ethyl acetate. The combined extracts were dried over magnesium sulphate and then evaporated. The brown foam obtained was triturated with ethyl acetate and diisopropyl ether to give 3.04 g of the title compound.
255 m.p. 211-214 ° C. HPLC (Method A): Rt<sub>T</sub> = 9.30 minutes.
Reference example
1- {6-Methoxy-1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridin-2-yl] -1H-indol-5-yloxy ethyl ester } cyclobutanecarboxylic acid mg sodium hydride (60% dispersion in mineral oil) was added to a stirring solution of 400 mg of 2- (5-hydroxy-6-methoxy-1-methyl-1H-indol-3-yl) under nitrogen at room temperature. -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 28 (a)] in 20 mL of dry dimethylformamide. The mixture was allowed to stir for 1 hour and then treated with '216 μΐ ethyl-1-bromocyclobutanecarboxylate' and stirring was continued overnight. An additional 43 mg of sodium hydride (60% dispersion in mineral oil) and 216 μΐ of ethyl 1-bromocyclobutanecarboxylate are added and the mixture is heated at 50 ° C for 5 hours. The reaction mixture was cooled and evaporated and the residue was partitioned between ethyl acetate and water. The organic phase is washed with water then brine, dried over magnesium sulphate and evaporated. The yellow residue was purified by flash column chromatography on silica gel eluting with ethyl acetate / pentane (2: 3, v / v) to give 266 mg of the title compound as a yellow oil. Mass Spectrum: MH + = 576;<sup>+</sup>). HPLC (Method A): Rt<sub>T</sub> = 11.07 minutes.
Reference Example 30 [1-Methyl-3- (ΙΗ-pyrrolo [2,3-b] pyrid-2-yl) -1H-indol-5-yl] carbamic acid tert-butyl ester
A solution of 0.3 g of {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-5- tert -butyl ester yl} carbamic [reference example 13 (f)] in 15 ml of methanol is reacted with ml of 5 N potassium hydroxide solution and then the mixture is heated
256 for 4 hours at reflux. The reaction mixture was evaporated and the residue was triturated with water to give 0.2 g of the title compound as a brown solid. Mass Spectrum: 263 (MH +);<sup>+</sup>). TLC: Rf = 0.3 (ethyl acetate).
Reference example 31
1 H -indole-6-carboxylic acid methyl ester
A solution of 10 g of 1H-indole-6-carboxylic acid in 300 ml of methanol is treated with 0.5 ml of concentrated sulfuric acid and then heated in a water bath for 10 hours. The solvent was evaporated under reduced pressure and the residue was partitioned between 150 ml of saturated aqueous sodium bicarbonate solution and 150 ml of dichloromethane. The aqueous layer was further extracted twice with 150. ml of dichloromethane. The combined organic extracts were dried over sodium sulfate and then evaporated. The residue was purified by flash column chromatography on silica gel, eluting with ethyl acetate: pentane (7: 3, v / v) to give 7.4 g of the title compound, mp 79-81 ° C. Mass Spectrum: 17.6 (MH +);<sup>+</sup>) .
Reference example 32
Dimethyl (6-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-ylmethyl) amine
A solution of 0.5 ml of 2M dimethylamine in tetrahydrofuran at 0 ° C is treated with 15 μΐ glacial acetic acid and then with 75 μΐ 40% formaldehyde solution. After stirring at 0 ° C for 10 minutes, this mixture is treated with 0.195 g of 6-phenyl-5H-pyrrolo [2,3-b] pyrazine [Example 2 (c)] and then 3 ml of tetrahydrofuran are added to ensure complete dissolution. The reaction mixture was allowed to warm to room temperature, then stirred overnight, diluted with 5 mL of ethyl acetate and extracted three times with 5 mL of 1 N hydrochloric acid. The combined acidic extracts are adjusted to pH 6-7 by the addition of 5 N potassium hydroxide solution.
257 the solid is filtered off, then washed with water and dried to give the title compound as a light yellow solid (0.16 g), m.p. 191-192 ° C.
Reference example 33
Trimethyl (6-phenyl-5-pyrrolo [2,3-b] pyrazin-7-ylmethyl) iodide
A solution of 5.1 g of dimethyl (6-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-ylmethyl) amine [Reference Example 32] in 100 mL of ethyl acetate at 0 ° C was treated with a solution of 40 mL of methyl iodide in 150 mL ml of ethanol. The resulting mixture was stirred for 2 hours at 0 ° C. The precipitated solid is filtered off, washed with 10 ml of ethyl acetate and then with 20 ml of diethyl ether to give 4.5 g of the title compound, m.p. 224-225 ° C.
Reference Example 34 (6-Phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) acetonitrile
A solution of 0.84 g of potassium cyanide in 20 ml of water is quickly added to a stirring solution of 1.1 g of trimethyl (6-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-ylmethyl) ammonium iodide [Reference Example 33 ] in 20 ml of dimethylformamide and the mixture is heated at 75 ° C for 6 hours. The cooled solution was diluted with 100 mL of water and the precipitated solid was filtered to give the title compound as a yellow solid, mp 247-248 ° C.
Reference example 35
(6-Phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) -acetic acid
A solution of 70 mg of (6-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) acetonitrile [Reference Example 34] in 5 ml of 10 M potassium hydroxide solution is heated at 100 ° C for 1.5 hours. . The reaction mixture is allowed to cool, then diluted with 25 ml of water and acidified to pH 1 by addition of concentrated hydrochloric acid. The resulting yellow solid was filtered, then washed with water and dried to give 40 mg of the title compound as a yellow solid, mp 276-277 ° C.
Reference example 36
1-Methyl-3- [1- (toluene-4-sulfony1) pyrrolo [2,3-b] pyridin-2-yl] -1 H -indole-5-carboxaldehyde
To a solution of 500 mg of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-5-carbonitrile [Reference Example] 13 (c)] in 20 ml of tetrahydrofuran, under a nitrogen atmosphere at 0 ° C, 12 ml of a 1M solution of diisobutylaluminum hydride in tetrahydrofuran is added. The resulting solution was then allowed to warm to room temperature and stirred at this temperature for 2 hours. The reaction mixture was then poured into 20 ml of cold 1 N aqueous hydrochloric acid. After 1 hour, the mixture was basified with saturated aqueous sodium hydroxide solution and extracted with 40 mL of ethyl acetate. The organic layer was separated and the aqueous layer was further extracted twice with 20 mL of ethyl acetate. The organic extracts were combined, dried over magnesium sulfate and evaporated in vacuo to give 221 mg of the title compound as a white solid, mp 188-189 ° C. Mass Spectrum: 430 (MH +);<sup>+</sup>) .
Reference example 37
Ethyl ester of the acid
3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indol-5-yl [acrylic ml of triethylphosphonoacetate was added with 22.4 mg of sodium hydride (60% dispersion in mineral oil) in 3 ml of dimethoxyethane are added to the suspension at 0 ° C. The resulting suspension was stirred for one hour at room temperature. 120 mg of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridin-2-yl] -1H-indole-5-car259 boxaldehyde is added [Reference Example 36] ] in 2 ml of dimethoxyethane and stirring was continued for 3 hours. The reaction mixture was then poured into water and extracted twice with 30 ml of ethyl acetate. The combined organic extracts were washed with brine and dried over magnesium sulfate and then evaporated in vacuo to give 126 mg of the title compound as a yellow solid, mp 159-162 ° C. Mass Spectrum: 500 (MH +);<sup>+</sup>) .
Reference Example 38 (a) 3- {1-Methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-5-ethyl ester yl} -propionic acid
15.7 mg of palladium (10% on charcoal) is added to a suspension of 100 mg of 3- {1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] ethyl ester pyrid-2-yl] -1 H -indol-5-yl} and crystallization [Reference Example 37] in 25 mL of industrial denatured ethanol (methanol). The resulting suspension was stirred for 16 hours under a hydrogen atmosphere. The reaction mixture was then filtered through a pad of diatomaceous earth and the filtrate was evaporated in vacuo. The resulting solid was then triturated with water, filtered to give 92 mg of the title compound as a white solid, mp 280-282 ° C. Mass Spectrum: 502 (MH +);<sup>+</sup>) .
(b) Using a similar procedure to that described in Example 38 (a), but using 3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) phenyl] prop- 2-ene [reference example 47], i
Preparation of 3- [2-dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenyl] -propionic acid ethyl ester as an orange gum, which was used directly in the next reaction without further purification. @ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]; δ 8.33 (1H, s); 8.17 (1 H, s); 7.94 (1 H, s);
<td> 7,82</td><td>(1 H,</td><td>d, J = 8.4 Hz); 7.20</td><td>(1H, d, J = 8.4Hz);</td><td>7.03 (1 H,</td>
<td>with) ;</td><td> 4,07</td><td>(2H, q, J = 7.6Hz);</td><td>3.38 (2H, t, J = 7.1)</td><td>Hz); 3.00</td>
<td>(2H,</td><td>t, J</td><td>= 7.1 Hz); 2.70 (6H, s)</td><td>; 1.19 (3H, t, J = 7.1)</td><td>Hz).</td>
Reference example
260
4-Methoxy-2- (5-methoxy-1H-indol-3-yl) -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine
In a similar manner to that described in Example 18, but using 2- (1-N-tert-butoxycarbonyl-5-methoxy-1H-indol-3-yl) -4-methoxy-1- (toluene-4-sulfonyl) 1H-pyrrolo [2,3-b] pyridine (Reference Example 40) was prepared as the title compound as a brown solid. HPLC (Method A): Rt<sub>T</sub> = 8.49 minutes. Mass Spectrum: 448 (MH +);<sup>+</sup>) .
Reference example
2- (l-tert-butoxycarbonyl-5-methoxy-lH-indol-3-yl) -4-methoxy-l- (toluene-4-sulfonyl) -lH-pyrrolo [2,3-b] pyridine
A stirred solution of 0.21 mL of diisopropylamine in 5 mL of tetrahydrofuran at -70 ° C for 5 minutes under a nitrogen atmosphere is treated with 0.6 mL of a 2.5 M solution of n-butyllithium in hexane while maintaining the temperature below -65 ° C. After 1 hour at -30 ° C, the mixture was added to a solution of 280 mg of 4-methoxy-1- (1-toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 41] in 10 ml of tetrahydrofuran while maintaining the temperature below -25 ° C. After warming to -15 ° C over 1 hour, 2.8 mL of a 0.5 M solution of zinc chloride in tetrahydrofuran was added while maintaining the temperature below -10 ° C. After 30 minutes, the reaction mixture is treated with 54 mg of tetrakis (triphenylphosphine) palladium (0) and 152 mg of 3-bromo-5-methoxy-indole-1-carboxylic acid tert-butyl ester [Reference Example 11 (a)], stirred for 16 min. hours at 60 ° C and then treated with 30 ml of water. The mixture was extracted three times with 25 mL of ethyl acetate. The combined organic extracts were washed twice with 15 ml of brine, dried over magnesium sulfate and evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate: pentane (1: 1, v / v) to give the title compound (45 mg) as a white foam. TLC: Rf<sub>F</sub> = 0.34 (ethyl acetate / pentane 1: 1). HPLC (Method A): Rt<sub>T</sub> = 9.72 minutes.
261
Reference example
4-Methoxy-1- (l-toluene-4-sulfonyl) -lH-pyrrolo [2,3-b] pyridine
A mixture of 0.77 g of 4-nitro-1- (1-toluene-4-sulfonyl) -4-pyrrolo [2,3-b] pyridine [Reference Example 9 (b)] and 25 ml of dry dimethylformamide is reacted with 0.17 g of sodium methoxide and stirred for 16 hours at 50 ° C. An additional 0.085 g of sodium methoxide is then added, stirring is continued for 8 hours and then the dimethylformamide is evaporated in vacuo. The residue was dissolved in 100 mL of ethyl acetate and washed with 60 mL of a 1: 1 mixture of water and brine. The organic extracts were dried over magnesium sulfate and evaporated. The residue was purified by flash column chromatography on silica gel, eluting with ethyl acetate, to give the title compound as a cream-colored solid. HPLC: Rt<sub>T</sub>= 9.73 minutes. @ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 8.22 (1H, d, J = 8.2 Hz); 7.96 (2 H, d,
J = 9.4 Hz); 7.71 (1H, d, J = 3.5Hz); 7.39 (2H, d, J = 9.4Hz);
6.89 (1H, d, J = 8.2Hz); 6.72 (1H, d, J = 3.5Hz); 3.93 (3 H, s); 2.30 (3 H, s).
Reference example 42
4-phenyl-lH-pyrrolo [2,3-b] pyridine
A suspension of 1.0 g of 1- (2,6-dimethyl-1,4-dihydropyridin-4-one) -1H-pyrrolo [2,3-b] pyridinium tetrafluoroborate [Reference Example 43] in 100 ml of tetrahydrofuran is reacted with 9.6 ml of a 1M solution of phenylmagnesium bromide in tetrahydrofuran and the mixture is stirred for 72 hours at room temperature, 100 ml of water are added and the tetrahydrofuran is evaporated in vacuo. The residue is extracted three times with 100 ml of chloroform and the combined extracts are dried over sodium sulphate and evaporated. The residue was purified by flash column chromatography on silica gel, eluting with dichloromethane: methanol (99: 1, v / v) to give the title compound as a white solid (83 mg). Mass Spectrum: 195 (MH +);<sup>+</sup>) .
@ 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SOJ: δ 8.27 (1H, d, J = 4.1Hz); 7.78 (2 H, d,
262
J = 8.2 Hz); 7.57 (3 H, m); 7.48 (1H, t, J = 8.2Hz); 7.19 (1H, d, J = 3.5Hz); 6.60 (1 H, s).
Reference example
1- (2,6-Dimethyl-1,4-dihydropyridin-4-one) -1H-pyrrolo [2,3-b] pyridinium tetrafluoroborate. .
A mixture of 28.5 g of ethyl O-2,4,6-trimethylsulfonylacetohydrate in 160 ml of 70% perchloric acid is stirred for 2 hours at room temperature and then 30 ml of dichloromethane are added. The mixture was poured into 1 L of water / ice and extracted rapidly with 100 mL of 100 mL of dichloromethane. The combined organic extracts were washed twice with 100 mL brine and dried over sodium sulfate. The organic extracts were added slowly to a solution of 11.8 g of 1H-pyrrolo [2,3-b] pyridine in 1-10 ml of dichloromethane. Filtration gave 1-amino-1H-pyrrolo [2,3-b] pyridinium-2,4,6-trimethylphenylsulfonate which was used directly in the next step.
A mixture of 16.6 g of 1-amino-1H-pyrrolo [2,3-b] pyridinium-2,4,6-trimethylphenylsulfonate and 8.8 g of 3-acetyl-6-methyl-2H-pyran-2,4 (3H). 1-Dione in 40 ml of concentrated hydrochloric acid is stirred for 4 hours at reflux, then cooled and evaporated in vacuo. The residue was dissolved in 30 ml of ethanol, diluted with 30 ml of a 54% (v / v) solution of tetrafluoroboric acid in diethyl ether and stirred for 1 hour at room temperature. After filtration, 15.0 g of the title compound is obtained as a white solid, m.p. 247-248 ° C. <sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 9.24 (1H, d, J = 7.5Hz); 9.13 (1H, d, J = 7.5Hz); 8.08 (1 H, d, J = 4.2 Hz); 7.93 (1H, t, J = 7.5Hz); 7.22 (1H, d, J = 4.2Hz); 6.83 (2 H, s); 1.96 (6 H, s).
Reference Example 44 (a) 3- [6- (4-tert-Butyl-phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] -propion-1,1-dicarboxylic acid dimethyl ester
263
To a solution of 1.3 g of dimethyl malonate dissolved in 30 ml of N-methylpyrrolidinone at 0 ° C under nitrogen is added 0.39 g of sodium hydride. After 10 minutes, a solution of 1.12 g of [6- (4- tert -butylphenyl-5 H -pyrrolo [2,3- b] pyrazin-7-yl] methyltrimethylammonium iodide [Reference Example 45 (a)], was added. The mixture was warmed to room temperature and allowed to stir for 3 hours The reaction mixture was poured into 200 mL of water and extracted three times with 100 mL of ethyl acetate. The combined organic fractions were dried over magnesium sulfate and evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate / pentane (1: 1, v / v) to give the title compound as a white solid (0.5 g). @ 1 H-NMR (CDCl3)<sub>3</sub>): δ 9.48 (1H, s); 8.42 (1 H, s); 8.16 (1 H, s); 7.64 (2H, d, J = 9.0Hz); 7.58 (2H, d, J = 9.0Hz); 4.45 (1H, t, J = 8.2Hz); 3.63 (2H, d, J = 8.2Hz); 3.58 (6 H, s); 1.40 (9 H, s).
(b) By a similar procedure to that described in Reference Example 44 (a), but using [6- (4- (1-methyl) ethoxy) phenyl-5 H -pyrrolo [2,3- b] pyrazine-7] -yl] methyltrimethylammonium iodide [Reference Example 45 (b)], dimethyl 3- [6- (4- (1-methyl) ethoxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] propionate is prepared -1,1-dicarboxylate as a beige solid. Mass Spectrum: 398 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR (CDCl 3): δ
<td>10.1 (broad</td><td>s, 1H); 8.41 (d,</td><td>1H, J = 2.3Hz); 8.16</td><td>(D,</td><td>1H,</td>
<td>J = 2.3 Hz);</td><td>7.62 (d, 2 H,</td><td>J = 8.21 Hz); 7.03</td><td>(D,</td><td>2H,</td>
<td>J = 8.20 Hz);</td><td>4.64 (m, IH); 4.45</td><td>(t, 1 H); 3.78 (d, IH);</td><td> 3, 60</td><td>(with,</td>
<td>6H); 1.41 (d,</td><td>6H, J = 4.41 Hz).</td><td></td><td></td><td></td>
<td>(c) Similar</td><td>how to</td><td>in reference</td><td colspan="2">Example</td>
(a), but using [6- (4-fluorophenyl) -5 H -pyrrolo [2,3- b] pyrazin-7-yl] methyltrimethylammonium iodide [Reference Example 45 (c)], dimethyl-3- [6- (4-Fluoro-phenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] -propion-1,1-dicarboxylate as an off-white solid. <sup>X</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO] 12.2 (s, 1H), 8.4 (d, 1H), 8.2 (d, 1H), 7.8 (d, 2H),
7.4 (d, 2H); 4.4 (t, 1H); 3.7 (s, 6H); 3.6 (d, 2H). Mass Spectrum: 357 (MH +);<sup>+</sup>) .
264 (d) By a similar procedure to that described in Reference Example 44 (a), but using [6- (4-methoxyphenyl) -5 / 7-pyrrolo [2,3-b] pyrazin-7-yl] methyltrimethylammonium iodide [Reference Example] 45 (d)], dimethyl 3- [6- (4-methoxyphenyl) -5 H -pyrrolo [2,3- b] pyrazin-7-yl] propionate 1,1-dicarboxylate is prepared as an off-white solid. Mass Spectrum: 369 (MH +);<sup>+</sup>) .
Reference Example 45 (a) [6- (4-tert-Butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] methyltrimethylammonium iodide
To a solution of 0.8 g of [6- (4-tert-butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] methyldimethylamine [Reference Example 46 (a)] in 50 ml of tetrahydrofuran under a nitrogen atmosphere at at 40 ° C
4.5 ml of methyl iodide. The reaction mixture was stirred for 4 hours and the solvent was evaporated. The residue was evaporated with 30 mL of toluene and dried in vacuo to give the title compound which was used immediately in the next reaction without further purification.
(b) By a similar procedure to that described in Reference Example 45 (a), but using 6- (4- (1-methyl) ethoxy) phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] methyldimethylamine [Reference Example 46 (b)], [6- (4- (1-methyl) ethoxy) phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] methyltrimethylammonium iodide was prepared as a beige solid, which was is used immediately in the next reaction without further purification.
(c) By a similar procedure to that described in Reference Example 45 (a), but using [6- (4-fluorophenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl) methyldimethylamine [Reference Example 46 ( c)], 6- (4-fluorophenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] methyltrimethylamino
<td colspan="2">niumjodid vo</td><td colspan="2">form yellow</td><td>solid. <sup>X</sup>@ 1 H-NMR .delta<sub>3</sub>)</td><td><sub>2</sub>SO]</td><td>: δ 13.0</td>
<td>(with,</td><td>1H), 8.5</td><td>(D,</td><td>1H), 8.4</td><td>(d, 1H), 7.7 (d, 2H), 7.6</td><td>(D,</td><td>2H), 3.1</td>
<td>(D,</td><td>2H), 2.9</td><td>(with,</td><td colspan="2">9H). Mass Spectrum: 285 (MH +);<sup>+</sup>) .</td><td></td><td></td>
(d) By a similar procedure to that given in the reference example
265
45 (a), but using [6- (4-methoxyphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] methyldimethylamine [Reference Example 46 (d)], prepare
6- (4-Methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazin-7-yl] methyltrimethylammonium iodide as an off-white solid. Mass Spectrum: 297 (MH +);<sup>+</sup>) .
Reference Example 46 (a) [6- (4-tert-Butylphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] mesyldimethylamine
To 15 ml of a 2M solution of dimethylamine in tetrahydrofuran and 0.45 ml of acetic acid at 0 ° C was added 2.25 ml of a 40% aqueous acetic acid solution. The reaction mixture was stirred for 10 minutes. A solution of 6.9 g of 6- (4-tert-butylphenyl) -5H-pyrrolo [2,3-b] pyrazine [Example 1 (w)] in 400 ml of tetrahydrofuran was added and the reaction mixture was allowed to stir overnight at room temperature. . The reaction mixture was washed with 1 N sodium hydroxide solution and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by flash column chromatography on silica gel, eluting with a mixture of tetrahydrofuran and methanol (1: 1, v / v) to give 0.8 g of the title compound as a yellow solid. Mass Spectrum: 309 (MH +);<sup>T</sup>). HPLC (Method A): R t = 1.93 minutes.
(b) In a similar manner to that described in Reference Example 46 (a), but using 6- [4- (1-methyl) ethoxyphenyl] -5H-pyrrolo [2,3-b] pyrazine [Example 1 (aa)] 6- (4- (1-methyl) ethoxy) phenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] methyldimethylamine was prepared as a beige solid.
(c) By a similar procedure to that described in the reference example
46 (a), but using 6- (4-fluorophenyl) -5,7-pyrrolo [2,3-b] pyrazine [Example 1 (ae)], [6- (4-fluorophenyl-5 H -pyrrolo [ 2,3-b] pyrazin-7-yl] methyldimethylamine as an off-white solid.
<sup>X</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 12.0 (s, 1H), 8.5 (d, 1H), 8.2 (d, 1H), 7.7
266 (d, 2H), 7.6 (d, 2H), 3.9 (d, 2H), 2.9 (s, 6H). Mass Spectrum: 270 (MH +);<sup>+</sup>) .
(d) By a similar procedure to that described in Reference Example 44 (a), but using 6- (4-methoxyphenyl) -5H-pyrrolo [2,3-b] pyrazine [Example 1 (af)], [6] was prepared. - (4-Methoxyphenyl-5H-pyrrolo [2,3-b] pyrazin-7-yl] methyldimethylamine as an off-white solid Mass spectrum: 282 (MH +)<sup>+</sup>) .
Reference example
3- [2-Dimethylamino-5- (5H-pyrrolo [2,3-b] pyrazin-6-yl) -phenyl] -prop-2-enoic acid ethyl ester
To a solution of 0.1 g of 6- (4-amino-3-bromo) phenyl-5H-pyrrolo [2,3-b] pyrazine [Reference Example 48] in 10 ml of dimethylformamide in a Schlenk flask is added 0.25 ml of ethyl acrylate, 0.05 g of palladium acetate, 0.07 g of tris (2-methylphenyl) phosphine and. 0.8 g of tributylamine. The flask is sealed, heated to 95 ° C for 24 hours and then allowed to stand at room temperature for 24 hours. The reaction was quenched by the addition of 150 mL of water and extracted with 100 mL of ethyl acetate, washed with brine and dried over magnesium sulfate. After evaporation in vacuo, the orange gum obtained was triturated with toluene to give 0.04 g of the title compound as an orange solid. TLC: R f = 0.46
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Reference example
6- (3-Bromo-4-dimethylamino) phenyl-5H-pyrrolo [2,3-b] pyrazine
To a stirred solution of 2.19 g of 4- (dimethylamino) benzonitrile in 15 ml of chloroform was added dropwise 1.2 ml over 45 minutes.
267 pyridine and a solution of 0.75 ml of bromine in 15 ml of chloroform. After the addition was complete, the mixture was stirred for an additional 30 minutes. The reaction mixture was diluted with dichloromethane and washed with water and brine, and evaporated to give 3-bromo-4- (dimethylamino) benzonitrile as a yellow oil which was dissolved in 25 mL of tetrahydrofuran. Meanwhile, a stirred solution of 2.7 mL of diisopropylamine in 50 mL of tetrahydrofuran was treated with 7.70 mL of a 2.5 M solution of n-butyllithium in hexane for 30 minutes at -15 ° C in nitrogen atmosphere while maintaining the temperature below -10 ° C. After 30 minutes, the mixture was treated with 1.21 g of methylpyrazine for 15 minutes and then stirred for 1 hour. A solution of 3-bromo-4- (dimethylamino) benzonitrile is added over 1 hour at a temperature below -10 ° C. The reaction mixture was allowed to warm to room temperature for 2 hours, then allowed to stand overnight and treated with 10 mL of water. The tetrahydrofuran was evaporated in vacuo and the resulting mixture was treated with water / ethyl acetate (1: 1, v / v) and stirred for 15 minutes. The resulting precipitate was filtered off and washed thoroughly with water / ethyl acetate (1: 1, v / v) to give 1.0 g of the title compound as a yellow solid. TLC: R f = 0.41 (ethyl acetate).
Reference example
6- [3- (tert-butyldimethylsilyloxy) -4-methoxyphenyl] -5 H -pyrrolo
- [2,3-b] pyrazine
A stirred solution of 3.6 mL of diisopropylamine in 133 mL of tetrahydrofuran at -15 ° C under nitrogen was treated with 11.21 mL of a 2.5 M solution of n-butyllithium in hexane while maintaining the temperature below -10 ° C. After stirring for 30 minutes, the mixture is treated with 2.04 g of methylpyrazine for 15 minutes and then treated with a solution of 5.7 g of 3- (tert-butyldimethylsilyloxy) -4-methoxybenzonitrile [Reference Example 50] in 20 ml of tetrahydrofuran for 1 hour. the temperature is maintained below -10 ° C. The reaction mixture was allowed to warm to room temperature for 2 hours, then allowed to stand overnight and treated with 10 mL of water. The tetrahydrofuran was evaporated in vacuo
268 the resulting mixture was partitioned between ethyl acetate and water. The two layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate and evaporated. The residue was purified by flash column chromatography on silica gel, eluting with dichloromethane: methanol (32: 1, v / v) to give 1.62 g of the title compound as a brown solid, which was used directly in the next step.<sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO): δ 8.12 (1H, s); 7.96 (1 H, s); 7.44 (1H, d, J = 8.2Hz); 7.33 (1 H, s); 6.93 (1H, d, J = 8.2Hz); 6.84 (1 H, s); 3.63 (3 H, s); 0.82 (9 H, s); 0.01 (6 H, s).
Reference example 50
3- (tert-butyldimethylsilyloxy) -4-methoxybenzonitrile
A solution of 10.0 g of isovanillin in 100 ml of dimethylformamide was treated with 9.14 g of hydroxylamine hydrochloride and heated to reflux for 1 hour. The dimethylformamide was evaporated under reduced pressure and the residue was partitioned between ethyl acetate and water. The aqueous fractions were extracted with ethyl acetate and the combined organic fractions were dried over sodium sulfate and evaporated in vacuo to give a brown solid which was dissolved in 200 mL of tetrahydrofuran. After reaction with 2.8 g of sodium hydride, the reaction mixture is stirred for 1 hour at room temperature. A solution of 10.9 g of tert-butyldimethylsilyl chloride in 50 ml of tetrahydrofuran was added and the mixture was stirred under nitrogen overnight. The mixture was partitioned between water and diethyl ether. The organic extracts were dried over sodium sulfate, evaporated in vacuo and purified by flash column chromatography on silica gel eluting with pentane / dichloromethane (1: 3, v / v) to give 14.7 g of the title compound as a white solid. colorless oil, which is used immediately in the next reaction. <sup>1</sup>1 H-NMR [(CD 3)]<sub>2</sub>SO): δ 7.30 (1H, d, J = 8.0Hz); 7.11 (1 H, s); 7.01 (1 H, s); 3.70 (3H,
with) ; 0.81 (9 H, s); 0.01 (6H, s).
Reference example 51
269
4- (1-Methyl) ethoxybenzonitrile
A solution of 1 g of 4-cyanobenzene in 10 ml of hexamethylenetetraamine is stirred at room temperature until dissolution. 2.7 ml of a 25% aqueous sodium hydroxide solution are added at room temperature over 30 minutes. 5.71 g of 1-methylethyl iodide are added dropwise and the solution obtained is stirred for 5 hours at room temperature and then poured into 30 ml of water. The mixture is extracted three times with 30 ml of ethyl acetate and the combined organic extracts are washed with water and brine, then dried over magnesium sulphate and evaporated. The residue was purified by flash column chromatography on silica gel eluting with ethyl acetate / heptane (1: 1, v / v) to give the title compound as a white solid (1.2 g). Mass Spectrum: 162 (MH +);<sup>+</sup>) . <sup>X</sup>@ 1 H-NMR .delta<sub>3</sub>)<sub>2</sub>SO]: δ: 7.58 (d, 2H, J = 8.12 Hz); 6.84 (d, 2H, J = 8.12 Hz); 4.62 (m, IH); 1.38 (d, 6H, J = 5.4Hz).
Reference example
5-Cyano-1-methyl-2-methylthio-1 H -imidazole
A solution of 0.76 g of 1-methyl-2-methylthio-1H-imidazole-5-carboxaldehyde [Reference Example 53 (a)] in 15 ml of dimethylformamide is treated with 0.68 g of hydroxylamine hydrochloride. The mixture was heated at reflux for 4 hours and poured into water. Ethyl acetate was added and the organic layer was washed with water and brine, dried, dried over magnesium sulfate and evaporated to give 0.4.7 g of the title compound as a beige solid, mp 115 ° C, which was used without purification. further purification. Mass Spectrum: 154 (MH +);<sup>+</sup>) .
Reference Example 53 (a) 1-Methyl-2-methylthio-1H-imidazole-5-carboxaldehyde
A stirred solution of 8.1 g of 1-methyl-2-methylthio-1H-imidazol-5-ylmethanol [Reference Example 54] and 28.97 g of manganese dioxide in 160 ml of dichloromethane was heated at reflux for 7 hours. . The reaction mixture was cooled to room temperature and filtered through diatomaceous earth. Evaporate the dichloromethane to give 6.61 g of the title compound as a yellow solid, which is used immediately in the next reaction.
(b) By a similar procedure to. is given in Reference Example 53 (a), but using 1-methyl-5-phenylpyrazol-3-ylmethanol [Reference Example 66], 1-methyl-5-phenylpyrazole-3-carboxaldehyde is prepared with a melting point of 106-108 ° C. .
Reference Example 54 1-Methyl-2-methylthio-1H-imidazol-5-ylmethanol
To a stirred suspension of 5 g of 1-methyl-2-thio-1H-imidazol-5-ylmethanol [Reference Example 55] in 500 ml of methanol is added dropwise 36 ml of 1N sodium hydroxide solution at room temperature. The suspension is stirred for 10 minutes at room temperature. Methyl iodide is added dropwise and stirring is continued for 12 hours. The methanol was evaporated and the residue was dissolved in dichloromethane and water was added. The organic layer was washed with water and brine, dried over magnesium sulfate and evaporated. The residue was crystallized from ether to give 4.3 g of the title compound as a white solid, m.p. 51 ° C.
Reference Example 55 1-Methyl-2-thio-1H-imidazol-5-ylmethanol
A mixture of 12.8 g of dihydroxyacetone dimer, 20.7 g of potassium thiocyanate and 12.4 g of methylamine is added to a solution of 16 ml of acetic acid and 100 ml of butanol. The white mixture obtained was stirred for hours, then suspended in 50 ml of water and filtered. The solid was washed with 60 mL of water and then 60 mL of diethyl ether and dried in vacuo to give 16 g of the title compound as a white solid, mp 204 ° C.
271
Reference Example 56 (a) 3-Cyano-1-methyl-1H-indazole
0.37 g sodium hydride (60% dispersion in mineral oil) is added to the solution under nitrogen at room temperature
1.20 g of 3-cyano-1H-indazole [Reference Example 57] v. 30 ml of dimethylformamide. The mixture was allowed to stir for 1 hour and then treated with 0.85 ml of methyl iodide and stirring was continued for 1 hour. The reaction mixture was then poured into 15 ml of ice water. The precipitated solid was filtered off, then washed with water and dried to give 0.80 g of the title compound as a beige solid, mp 73 ° C.<sup>X</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 7.91 (m, 2H); 7.60 (t, IH); 7.42 (t, IH); 4.21 (s, 3H).
(b) Using a similar procedure to that described in Reference Example 56 (a), but using 3-cyano-4-phenyl-1H-pyrrole [Reference Example 58], 3-cyano-1-methyl-4-phenyl- H-pyrrole.
Reference example
3-Cyano-indazol-Lif
A solution of 0.5 g o-aminobenzyl cyanide in 9.6 ml of 1N aqueous hydrochloric acid solution is treated with 3.85 ml of 1N sodium nitrite solution. After stirring at room temperature for 15 minutes, the reaction mixture was filtered. The solid was recrystallized from ethanol to give 0.4 g of the title compound as a yellow solid, mp 138-140 ° C.<sup>1</sup>1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]: δ 7.89 (d, 1H, J = 7.7 Hz); 7.76 (d, 1H, J = 7.9Hz); 7.48 (t, IH); 7.41 (t, 1 H).
Reference example
3-Cyano-4-phenyl-pyrrole-ΙΗ
A solution of 16.53 g of cinamonitrile and 25 g of (p-toluenesulfonyl) -methylisocyanide in 450 ml of a 2: 1 mixture of ether and dimethylsulfoxide)
272 is added dropwise to a stirring suspension of 6.14 g of sodium hydride (60% dispersion in mineral oil) in 50 ml of ether. Exothermic reaction in progress. The reaction mixture is stirred at room temperature for 2 hours, then 500 ml of water are added and the mixture is extracted three times with 250 ml of ether. The combined extracts were washed with brine, then dried over magnesium sulphate and evaporated. The residue was purified by silica gel filtration chromatography eluting with ethyl acetate / pentane (11: 1: 4, v / v) then ethyl acetate / pentane (2: 1, 2: 3, v / v). The fractions containing the desired material were evaporated and the residue was suspended with stirring in 500 ml of pentane and filtered to give the title compound as a solid, m.p. 120-122 ° C. Mass spectrum: 167 (MH +).
Reference example
4-pyrazinyl-butene, l
A solution of lithium diisopropylamide [prepared at -35 ° C from 100 mL of 2.5 M butyllithium in hexane and 25.3 g of diisopropylamine] at -20 ° C was treated with a solution of 23.5 g of 2-methylpyrazine in 300 mL of dry tetrahydrofuran. The mixture is stirred for 1 hour at -20 ° C, then cooled to -78 ° C and treated with a solution of 30.8 g of allyl bromide in 300 ml of dry tetrahydrofuran. The mixture was allowed to warm to room temperature and stirred at this temperature for 2 hours, then allowed to stand overnight and treated with 50 mL of saturated aqueous ammonium chloride solution and then with 200 mL of water. The mixture is then extracted twice with 200 ml of ether. The combined extracts were dried over magnesium sulphate and then evaporated. The residue was distilled to give the title compound (22 g) as a colorless oil, b.p. 70 ° C / 0.13 kPa.
Reference example
273
2- [5- (Pyrid-4-yl) -1-methyl-1H-indol-3-yl] -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine
A mixture of 1.7 g of 2- [5- (1-benzyloxycarbonyl-1,2,5,6-tetrahydropyrid-4-yl) -1-methyl-1H-indol-3-yl] -1- (toluene-4- sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 61], 53 mL of ethanol and
0.35 g of palladium on carbon was stirred for 4 hours in the presence of hydrogen and then allowed to stand overnight at room temperature. After another day, 0.18 g of 10% palladium on carbon is added and stirring in the presence of hydrogen is continued for an additional 8 hours. After standing at room temperature for 4 days, the mixture was filtered through Hyflo and the filter cake was washed with ethanol. The combined filtrates are treated with 0.35 g of palladium on carbon and the mixture is stirred in the presence of hydrogen. The mixture was filtered through Hyflo and the filter cake was washed with ethanol. The combined filtrates were evaporated and the residue was purified by silica gel flash column chromatography eluting with ethyl acetate: pentane (4: 1, v / v) to give the title compound as a light brown solid, mp 82-85 ° C.
Reference example 61
2- [5- (1-Benzyloxycarbonyl-1,2,5,6-tetrahydropyrid-4-yl) -1-methyl-1H-indol-3-yl] -1- (toluene-4-sulfonyl) - 1 H -pyrrolo [2,3- b] pyridine
A mixture of 2 g of benzyl 1- [3,6-dihydro-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -2 H -pyridinecarboxylate [prepared according to the procedure described in P Eastwood, Tetrahedron Lett., 41, 3705-3708 (2000)], 0.25 g of dichloro [1,1'-bis (diphenylphosphino) ferrocene] palladium (II), and 2.42 g of potassium carbonate are reacted with a solution under nitrogen. Trifluoromethanesulfonic acid 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1-indol-5-yl ester [Reference Example] 18 (a)] in 76 ml of dimethylformamide.
The mixture is heated at 80 ° C for 4 hours (starting material is still present by TLC), then reacted with additional
0.15 g of 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid274
2-yl] -1H-indol-5-yl trifluoromethanesulfonic acid ester, heated at reflux for 4 hours and allowed to stand overnight at room temperature. An additional 0.15 g of triflic acid 1-methyl-3- [1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyrid-2-yl] -1H-indole-5-yl ester was added. of fluoromethanesulfonic acid [Reference Example, 18 (a)] and the mixture was refluxed for a further 4 hours and evaporated. The residue was partitioned between ethyl acetate and water and the aqueous layer was extracted three times with 50 ml of ethyl acetate. The combined organic phases are washed with brine, then dried over magnesium sulphate and evaporated. The residue was purified by flash column chromatography on silica gel, eluting with ethyl acetate / pentane (1: 1, v / v) to give the title compound as a light brown viscous liquid which was used without further purification.
Reference Example 62 (a) 2-Iodo-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine-4-carbonitrile
A stirred solution of 0.38 mL of diisopropylamine in 7 mL of tetrahydrofuran at -70 ° C under a nitrogen atmosphere is treated for 5 minutes with 1.6 mL of a 2.5 M solution of n-butyllithium in hexane while maintaining the temperature below -65 ° C. . After stirring for 20 minutes, the mixture was added to a solution of 0.65 g of 1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine-4-carbonitrile [Reference Example 63] at -70 ° C in 15 ml of tetrahydrofuran and the mixture is stirred for 45 minutes at -70 ° C. A solution of 0.9 g of iodine in 10 ml of tetrahydrofuran is then added at -70 ° C. The reaction mixture is allowed to warm to room temperature over 1 hour, stirred for 18 hours and then treated with 10 ml of water. The reaction mixture was evaporated in vacuo and the residue was partitioned between 75 mL of ethyl acetate and 50 mL of water. The insoluble material was filtered off, washed with ether and dried under vacuum to give 0.45 g of the title compound as a white solid. The filtrate was separated and the organic phase was washed successively twice with 30 ml of a saturated aqueous solution of thio275 sodium sulfate, 30 ml of water and 30 ml of brine, dried over sodium sulfate and evaporated. The residue was triturated with diethyl ether to give 0.25 g of the title compound as a cream-colored solid. TLC R<sub>F</sub> = 0.43 (ethyl acetate / heptane 1: 1).
Mass Spectrum: 424 (MH +);<sup>+</sup>) .
(b) In a similar manner to that described in Reference Example (a), but using 4-chloro-1- (toluene-4-sulfonyl) -1 H -pyrrolo [2,3- b] pyridine [Reference Example 9 (c) 1], 4-chloro-2-iodo-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine was prepared as an off-white foam. Mass Spectrum: 432 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR (CDCl 3)?<sub>3</sub>): δ 8.25 (d, 1H), 8.05 (d, 2H), 7.3 (d, 2H), 7.15 (d, 1H), 7.1 (s, 1H),
2.4 (s, 3H).
(c) By a similar procedure to that described in Reference Example 62 (a), but using 5-phenyl-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 67], to give 2-iodo-5-phenyl-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a light brown solid.
(d) By a similar procedure to that given in the reference example
62 (a), but using 4-phenyl-1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 9 (e)], 2-iodo-4-phenyl is prepared -1- (toluene-4-sulfonyl) -1H-pyrrolo [2,3-b] pyridine as a white solid, which was used without further purification. 1 H-NMR [(CD<sub>3</sub>)<sub>2</sub>SO]; δ 8.43 (1H, d, J = 4.5Hz); 8.04 (2H, d, J = 8.2Hz); 7.98 (1H, d, J = 4.5Hz); 7.69 (2H, dd, J = 7.2 and 1.9 Hz); 7.56 (2H, tt, J = 7.2 and 1.9Hz); 7.44 (2H, d, J = 8.2Hz); 7.42 (1H, d, J = 5.0Hz), 6.92 (1H, d, J = 4.0Hz).
Reference example
1- (Toluene-4-sulfonyl) -lH-pyrrolo [2,3-b] pyridine-4-carbonitrile
A mixture of 5.0 g of 1- (2,6-dimethyl-1,4-dihydropyridin-4-one) -1-pyrrolo [2,3-b] pyridinium tetrafluoroborate [Reference Example 43] and ml of water are treated with 25 ml of saturated aqueous cyanide solution
276 potassium and stirred for 48 hours at room temperature. A solution of 2.9 g of toluene-4-sulfonyl chloride in 100 ml of toluene, a solution of 4.0 g of sodium hydroxide in 10 ml of water and 0.05 g of tetrabutylammonium hydrogen sulfate is added and the mixture is stirred for 72 hours at room temperature. The mixture was filtered through diatomaceous earth and extracted. The aqueous phase is extracted three times with 50 ml of ethyl acetate and the combined organic extracts are washed with 50 ml of water and 50 ml of brine, dried over magnesium sulphate and evaporated in vacuo. The residue was purified by flash column chromatography on silica gel.
<td>kieselguhr</td><td>taking</td><td>eluuj e</td><td colspan="2">mixture of ethyl acetate and heptane</td><td> (3 :</td><td> 7,</td>
<td colspan="2">by volume), and obtained</td><td>sa 1,1</td><td>g of compound</td><td>in the title</td><td colspan="2">in shape</td>
<td>white</td><td>solid</td><td>[TLC:</td><td>R? = 0.60</td><td>(Ethyl acetate / heptane</td><td> 3 :</td><td> 7) ;</td>
<td><sup>X</sup>H-NMR</td><td>[(CD<sub>3</sub>)<sub>2</sub>SO]:</td><td>δ 8.54</td><td>(LH, d, J)</td><td>= 4.7 Hz); 8.08</td><td>(2H,</td><td>d.</td>
<td>J = 8.2</td><td>Hz); 7.95 (</td><td>1H, d,</td><td>J = 3.6 Hz);</td><td>7.44 (1 H, d, J =</td><td colspan="2">4.3 Hz);</td>
7.31 (2H, d, J = 8.2Hz); 6.82 (1H, d, J = 3.3Hz); 2.39 (3H, s)] and 0.13 g of 1H-pyrrolo [2,3-b] pyridine-4-carbonitrile as a white solid [TLC: R p = 0.24 (ethyl acetate / heptane 3: 7) ;<sup>X</sup>@ 1 H-NMR .delta<sub>3</sub>)<sub>2</sub>SO]: δ 10.19 (1H, s); 8.44 (1H, d, J = 4.6Hz); 7.59 (1 H, m); 7.40 (1H, d, J = 4.6Hz), 6.78 (1H, m)].
Reference example
4-Chloro-lH-pyrrolo [2,3-b] pyridine
10.0 g of 1H-pyrrolo [2,3-b] pyridine-N-oxide [Reference Example 65] in 75 ml of phosphorus oxychloride are heated at reflux for 8 hours. under reflux. Excess phosphorus oxychloride was evaporated, the residue was taken up in water, the solution basified to pH 8-9 and the resulting precipitate was filtered off and air dried to give the title compound as an off-white solid (10.2 g). Mass Spectrum: 152 (MH +);<sup>+</sup>) . <sup>X</sup>1 H-NMR (CDCl 3)?<sub>3</sub>): δ 8.2 (d, 1H), 7.5 (d, 1H), 7.2 (d, 2H),
6.6 (d, 2 H).
Reference example
277
H-Pyrolo [2,3-b] pyridine-N-oxide
A solution of 224.3 g of 3-chloroperbenzoic acid in 1500 ml of dichloromethane is cooled to 0 ° C. To this solution was added dropwise 59.1 g of 1H-pyrrolo [2,3-b] pyridine over 30 minutes. The reaction mixture was stirred for 1 hour at room temperature. The solution was evaporated, diluted with 1500 mL of methanol and treated with 300 mL of 10% potassium carbonate in water. The suspension is filtered and the filtrate is evaporated to dryness. The residue was purified by neutral alumina chromatography eluting with 10% methanol in dichloromethane to give 47.0 g of the title compound as a brown solid. Mass Spectrum: 135 (MH +);<sup>+</sup>) . <sup>1</sup>1 H-NMR (CDCl 3)?<sub>3</sub>δ: 13.1 (s, 1H), 8.2 (d, 1H), 7.65 (d, 1H), 7.4 (d, 1H), 7.0 (m, 1H), 6, 55 (d, 1 H).
Reference Example 66 1-Methyl-5-phenylpyrazol-3-ylmethanol
A stirred suspension of 1.28 g of sodium borohydride in 80 ml of dry tetrahydrofuran is treated with 1.88 g of calcium chloride. The mixture is stirred for 1 hour and then treated with a solution of 5.2 g of methyl 1-methyl-5-phenylpyrazol-3-ylcarboxylate [prepared according to the procedure described by Martins et al., J. Heterocycl. Chem., 36 (1), 217-220 (1999)] in 40 mL of dry tetrahydrofuran. After stirring at room temperature for 8 hours under reflux, the mixture was treated with 50 ml of 1N sodium hydroxide solution. The mixture was stirred for 1 hour at room temperature, then evaporated to remove organic solvents, then extracted three times with 140 ml of dichloromethane. The combined extracts were washed with water, then dried over magnesium sulphate and evaporated to give the title compound as a white solid, mp 95-99 ° C.
Reference example
278
5-phenyl-1- (toluene-4-sulfonyl) -lH-pyrrolo [2,3-b] pyridine
A mixture of 1.74 g of phenylboronic acid, 5 g of 5-bromo-1- (toluene-4sulfonyl) -1H-pyrrolo [2,3-b] pyridine [Reference Example 9 (d)], 0.49 g of tetrakis (triphenylphosphine) of palladium (0), 133 ml of saturated aqueous sodium bicarbonate solution, and 266 ml of dimethylformamide are refluxed overnight under nitrogen. The reaction mixture was filtered through Hyflo and evaporated. The residue was partitioned between 50 mL of ethyl acetate and 25 mL of water and then the aqueous layer was extracted with 25 mL of ethyl acetate. The combined organic phases are washed with 25 ml of water and then with 20 ml of brine, dried over magnesium sulphate and evaporated. The residue was purified by silica gel column chromatography eluting with pentane / ether (1: 1, v / v) to give the title compound as a white solid, mp 151-152 ° C. Mass Spectrum: 335 (MH +);<sup>+</sup>) .
In vitro test procedures
A. In vitro test procedures for Syk
First Inhibitory effects of compounds on Syk kinase
Syk kinase inhibitory effects of a compound are determined using a time-resolved fluorescence assay.
The catalytic domain of Syk kinase (residues A340-N635) is expressed as a fusion protein in yeast cells and purified to a homogeneous phase. Kinase activity is determined in 50 mM Tris-HCl buffer pH 7.0 containing 50 mM NaCl, 5 mM MgCl<sub>2</sub>, 5 mM MnCl<sub>2</sub>, 1 μΜ of adenosine triphosphate and 10 μΜ of the synthetic peptide Biotin- (β-alanine) 3-DEEDYEIPP-NH2. The enzyme reaction is terminated by the addition of a buffer containing 0.4 M KF, 133 mM EDTA, pH 7.0, containing the streptavidin-XL665 conjugate and a monoclonal phosphospecific antibody conjugated to europium cryptate (Eu-K). The properties of two fluorophores, XL-665 and Eu-K, are reported in G. Mathis et al., Anticancer
279
Research, 17, 3011-3014 (1997). The specific long-term XL-665 signal, produced only when the synthetic protein is phosphorylated by Syk, is measured on a Packard Discovery Microplate. Inhibition of Syk activity by compounds of the present invention is expressed as percent inhibition of control activity achieved in the absence of test compounds. In particular, the compounds of the present invention inhibit Syk activity at IC<sub>50</sub> in the range of 100 μΜ to 10 nM. Preferred compounds of the present invention inhibit Syk activity at an IC 50 in the range of 100 nM to 10 nM.
Second Antigen-induced degranulation of rat BOS cells measured by release [<sup>3</sup>H] -5-Hydoxytryptamine (serotonin)
2.1 Cell culture, labeling of RBL-2H3 cells and assay of properties
Wash 6 x 10 for each 24-well culture plate to be used<sup>6</sup> of RBL-2H3 cells and resuspended in 15 ml DMEM-10 containing 25 μΐ 1 mCi / ml [<sup>3</sup>H] -serotonin (final concentration 0.5 μθί / πι1) and 1 μg / ml (15 ml) of anti-DNP IgE. 0.5 ml of cell suspension is added to each well of a 24-well microtiter plate. The cells are incubated for 2 days at 37 ° C until confluence is reached. The medium is mixed gently in each well and the cells are then washed with assay buffer. A final volume of 200 ml of assay buffer (+ or - test compound at the appropriate concentration) is then added to the well in triplicate. In each well (except the negative control wells, i.e. wells) to measure spontaneous release [<sup>3</sup>H 1 -serotonin in the absence of receptor cross-linking) is then added 100 ng / ml DNP (antigen). The cells are then incubated for 30 minutes at 37 ° C, and the reaction is terminated by transferring 100 μΐ of the supernatant from each sample to a liquid scintillation microtiter plate placed on ice. Then 200 μ 200 of scintillant-40 reagent is added to each well of the microtiter plate and the plate is read on the instrument.
280
Topcount Liquid Scintillation Counter.
2.2. Calculation of results (i) For each well group in triplicate, the mean ± standard deviation of the mean is calculated.
(ii) Positive control wells containing antigen (10 ng / ml) but not containing compound had maximal response.
(iii) Control wells containing neither antigen nor compound had minimal response.
(iv) Using these values as maximum (100%) and minimum (0%) values, the data are normalized to yield maximum percent responses.
(v) Plot a dose-response curve and calculate IC values<sub>50</sub> The corresponding compounds are obtained.
The compounds of the present invention inhibit antigen-induced degranulation of rat BOS cells at EC<sub>5</sub>in the range of 100 μΜ to 0,01 μΜ.
B. In vitro DRC Assay Procedure
First Inhibitory effects of compounds on DRC
The inhibitory effects of the compounds on the KDR-substrate phosphorylation assay were determined using a flashplate assay (96-well microtiter plate, New England Nuclear).
The cytoplasmic domain of the human enzyme was cloned as a fusion with glutathione-S-transferase (GST) into the pFastBac-GST labeled (reading frame) B baculovirus expression vector. The protein was expressed in SF21 cells and purified to 60% homogeneity.
Kinase activity was determined in 20 mM sodium acid salt
4-morpholine-propanesulfonic acid, 10 mM MgCl2, 10 mM MnCl2, 1 mM dithio281 treitole, 2.5 mM ethylene glycol bis (β-aminoethyl ether) -N, N'-tetraacetic acid, 10 mM β-glycerol phosphate, pH 7.2, containing 10 mM MgCl<sub>2</sub>, 100 μΜ Na3VO<sub>4</sub> and 1 mM NaF. Add 10 μΐ of compound at 4 ° C to 70 μΐ of kinase buffer containing 100 ng kinase domain receptor (KDR) enzyme. The reaction is initiated by adding 20 μ 20 of a solution containing 2 µg of substrate (SH2-SH3 PLCy fragment expressed as GST fusion protein), 2μθί [γ-<sup>33</sup>Ρ] -AlΤΡ and 2μΜ cold ATP. After 1 hour incubation at 37 ° C, the reaction is terminated by adding 1 volume (100 μΐ) of 200 mM EDTA. The assay buffer is then discarded and the wells are washed three times with 300 μΐ phosphate buffered saline (PBS). Radioactivity is measured for each well using a Packard Model Top Count NXT.
The background signal is derived from a four-fold measurement of radioactivity in wells containing radioactive ATP and substrate alone in kinase buffer.
Control activity is derived by measuring radioactivity in wells containing the complete test cocktail ([γ-<sup>33</sup>Ρ] -ATP, KDR and PLCg substrate) in the absence of test compound.
Inhibition of KDR activity by a compound of the present invention is expressed as a percentage inhibition of the activity indicated in the absence of the test compound.
SU5614 1 μΜ (Calbiochem) is added to each plate in quadruplicate as an inhibition control.
IC values<sub>50</sub> are calculated for the compounds of the present invention by plotting a dose-response curve. IC 50 values correspond to the concentration of a compound of the present invention that causes 50% inhibition of kinase activity.
In particular, the compounds of the present invention inhibit KDR activity at IC<sub>50</sub> in the range of 100 μΜ to 0.3 μΜ.
2.
Cell activity on endothelial cells
282
2.1 Inhibition of Vascular Endothelial Growth Factor (VEGF) Dependent on Human Dermal Microvascular Cells (HDMEC)
The anti-KDR activity of the molecules of the present invention is evaluated by absorption [<sup>14</sup>C-thymidine into HDMEC (human dermal microvascular endothelial cells) in response to VEGF.
HDMECs (Promocell, passages 5-7) are inoculated on day 1 into 100 µl at 5000 cells per well in 96-well Cytostar plates (Amersham) pre-coated with Attachment Factor (AF, Cascad Biologics) at 37 ° C in 5% CO2. On day 2, the complete culture medium (basal medium supplemented with 5% fetal bovine serum (FCS) and growth factor cocktail) is replaced with minimal medium (basal medium supplemented with 5% FCS) and the cells are incubated for an additional 24 hours. On day 3, the medium is replaced with 200 µl of fresh minimal medium supplemented or not with 100 ng / ml VEGF (R & D System) and containing or not containing the compound of the present invention and 0.1 pCi [<sup>14</sup>C] -thymidine. Cells are incubated at 37 ° C in 5% CO 2 for 4 days. Absorption [<sup>14</sup>C-thymidine is then quantified by radioactivity counting. The tests are performed in triplicate. The final DMSO concentration in the assay is 0.1%. Percent inhibition is calculated according to the following formula:
[Cpm (+ VEGF) - Cpm<sub>(+</sub>VEGF + cpd) / cpm<sub>(</sub>+ vEGF) - tpm (3M5% FCS)] <sup>X</sup> Ιθθ
2.2 Effect of molecules on HDMECs independent of VEGF
HDMEC (5000 cells per well) are inoculated on day 1 in complete medium (CM) in 96-well Cytostar plates (Amersham) pre-coated with binding factor (AF, Cascad Biologics) at 37 ° C in 5% CO<sub>2</sub>. The complete medium is then removed and the cells are incubated in 200 µl of the complete medium containing the molecules of the invention and [<sup>14</sup>C-thymidine (0.1 pCi). Absorption [<sup>14</sup>C-thymidine is quantified using a Wallac Betaplate after 3 days of incubation. Percent inhibition is calculated according to
283 of the following formula:
[Cpira (CM) <sup>-</sup> cprn<sub>(C</sub>M + cpd; / cpmjcM)] x 100
C. Aurora2 in vitro assay
First Inhibitory effects of compounds on Aurora2 kinase
Aurora2 kinase inhibitory effects of compounds are determined using a nickel-chelate radioactive flashplate assay.
The full-length N-terminal His-tagged recombinant Aurora2 is expressed in E. coli and purified to near homogeneity.
N-terminal His-labeled NuMA (nuclear protein associated with the mitotic apparatus) The C-terminal fragment (Q1687-H2101) is expressed in E. coli, purified by nickel chelate chromatography and used as a substrate in the Aurora2 kinase assay . To determine kinase activity, the NuMA substrate is freshly equilibrated in kinase buffer (50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 10 mM MgCl 2) supplemented with 10% (v / v) glycerol and 0.05% (w / v). NP40 by Pharmacia PD10 column chromatography.
Aurora2 kinase activity is measured on a nickel-chelate flashplate (New England Nuclear, model SMP107). Each well contains 100 μΐ of the following solution: 0.02 μΜ Aurora2; 0.5 μΜ of NuMA substrate; 1 μΜ ATP supplemented with 0.5 pCi [γ-<sup>33</sup>Ρ] -ΑΤΡ. The solutions were incubated for 30 minutes at 37 ° C. The assay buffer is then discarded and the wells are washed twice with 300 μΐ of kinase buffer. Radioactivity is measured in each well using a Packard Model Top Count NXT.
The background signal is derived from the measurement of radioactivity in duplicate in wells containing radioactive ATP alone in kinase buffer treated in the same way as other samples. Control activity is derived from the measurement of radioactivity in duplicate in wells containing the complete test cocktail (ATP, Aurora2, and NuMA substrate) in the absence of test compound. valuables.
Inhibition of Aurora2 activity by the compound of the present invention is expressed as the percentage inhibition of the control activity indicated in the absence of test compound. Staurosporine is added to each plate as an inhibition control.
IC 50 values for compounds of the present invention are calculated by plotting and dose response curve. IC 50 values correspond to the concentration of a compound of the present invention which causes 50% inhibition of kinase activity.
In particular, the compounds of the present invention inhibit Aurora2 activity at an IC 50 in the range of 100 μΜ to 0.3 μΜ.
C. In vitro FAK Assay Procedure
First Inhibitors of Effects of Compounds on FAK
The inhibitors of FAK kinase effects - an autophosphorylation assay - are determined using a time-resolved fluorescence assay.
The full-length human enzyme cDNA was cloned into the pFastBac HTc baculovirus expression vector. The protein was expressed and purified to about 70% homogeneity.
Kinase activity was determined in 50 mM Hepes, pH 7.2, containing 10 mM MgCl<sub>2</sub>, 100 μΜ Na<sub>3</sub>VO<sub>4</sub>, 15 μΜ of adenosine triphosphate. Enzyme reaction is terminated by addition of Hepes buffer, pH 7.0, containing 0.4 M KF, 133 mM EDTA, 0.1% BSA containing XL665-labeled anti6His antibody (FAK is His-labeled) and monoclonal tyrosine phosphospecific antibody conjugated to europium cryptate (eu-K). The properties of both fluorophores, XL-665 and Eu-K, are reported in G. Mathis et al., Anticancer Research, 17, 3011-3014 (1997). The specific long-term XL-665 signal, produced only when the FAK enzyme is autophosphorylated, is measured on a Packard Discovery Microplate Analyzer. Inhibition of FAK activity
285 The present invention is expressed as percent inhibition of control activity indicated in the absence of test compound.
Second Proliferation / viability of human melanic cellsoma SK-Mel-28 measured by absorption [<sup>14</sup>C] -thymidine
I
2.1 Cell culture, SK-Mel-28 labeling and assay
SK-Mel-28 are inoculated on day 1 at 5000 cells per well in 96-well Cytostar plates (Amersham) at 37 ° C in 5% CO.<sub>2</sub>. On day 2, the medium is replaced with fresh Eagle's Minimum Essential Medium (MEM) supplemented with 10% FCS, 1% non-essential amino acids, 1% sodium pyruvate, and containing 0.1 pCi [<sup>14</sup>CJ thymidine and increasing compound concentrations in 200 μΐ of final volume. Cells are incubated at 37 ° C in 5% CO<sub>2</sub> 48 hours. Absorption [<sup>14</sup>C-thymidine is quantified by counting the radioactivity 48 hours after the start of processing. Assays are performed in wells in triplicate.
2.2. Calculation of results (i) For each set of three wells, calculate the mean ± standard deviation.
(ii) Positive control wells containing cells but containing no test compound had maximal response.
(iii) Control wells containing no cells and no compound had minimal response.
(iv) Using these values as maximum (100%) and minimum (0%) values, the data are normalized to give a percentage of the maximum response.
(v) Plot a dose-response curve and calculate IC values<sub>50</sub> (concentration of drug that causes a 50% increase in absorption [<sup>14</sup>C-thymidine) for compounds.
286
Third Migration of SK-Mel-28 human melanoma cells on a fibronectin matrix
3.1. Cell culture and assay
SK-Mel-28 (250000 cells) are pretreated with increasing concentrations of compounds for 15 minutes at 37 ° C in 5% CO 2.<sub>2</sub>. They are then placed in the presence of the compound on the upper side of a 12 µm 12-well Boyden chemotaxis chamber (Becton Dickinson) and left at 37 ° C in 5% CO 2 for 24 hours.<sub>2 </sub>migrate into the lower chamber containing fibronectin (10 µg / ml) as a chemoattractant in basal RPMI culture medium. Cells are then fixed and stained in Diff-Quick (Diff-Quick Fix, Solutions I and II, Dade Behring) and cells from the top of the chamber are removed. The color is solubilized from the underside of the adherent cells and the cell migration is quantified by measuring the optical density. The assay is performed in wells in duplicate.
3.2. Calculation of results (i) For each set of two wells, calculate the mean ± standard deviation.
(ii) Positive control wells containing cells but containing no test compound had maximal response and allowed migration to fibronectin.
(iii) Minimum responses were control wells containing cells but not containing any compound, and allowed migration to basal culture medium w / o chemoattractant.
(iv) Using these values as maximum (100%) and minimum (0%) values, the data are normalized to give a percentage of the maximum response.
(v) Plot a dose response curve and calculate IC 50 values (drug concentration that causes a 50% reduction in cell migration) for the compounds.
287
In particular, the compounds of the present invention inhibit FAK activity at an IC 50 in the range of 100 μΜ to 0.3 μΜ.
In vivo test procedures
First Inhibition of antigen-induced airway inflammation - single and multiple daily oral administration study
The compounds of the present invention are tested in Brown Norway rats. The models used in these in vivc studies mimic the corresponding pathological characteristics of allergic airway disease. These studies have shown that the compounds of the present invention inhibit the accumulation of inflammatory cells in the allergic airways 24 hours after antigen inhalation. The results obtained at the end of the study demonstrated the incidence of inflammatory leukocytes in bronchoalveolar lavage fluid (BALF), lung fluid and tissue, as analyzed by histopathological analysis.
Procedure for sensitization and antigenic stimulation
Brown Norway rats are sensitized on days 0, 12 and 21 with ovalbumin (100 µg, ip) administered with aluminum hydroxide (100 mg, ip). On day 30, rats are exposed to 1% ovalbumin aerosol for 30 minutes. The animals are then returned to the cages.
Dosing procedure
The test drug is administered orally 1 hour before initiation of stimulation by allergen inhalation. A second dose of the drug is orally administered 4 hours after the inhalation of antigen inhalation. Doses of the compound are administered in divided doses of 3 to 100 mg / kg.
In separate studies, the drug is administered twice daily 4 days prior to antigen inhalation. The final dose of the compound in these studies was also administered 4 hours after antigen challenge.
Procedure for obtaining bronchoalveolar lavage fluid (BAL)
288 hours after stimulation by antigen inhalation, cells are recovered from the airway lumen by bronchoalveolar lavage of sacrificed animals and the lungs are washed three times with 5 ml aliquots of RPMI / FCS. The wash fluid is left in the lungs for 30 seconds and then carefully removed. Three samples are pooled and total and differential white blood cell counts are measured in BAL samples. The ARGOS system was used to determine the total cell count, and light microscopy of Wright-Giems stained cytocentrifuged preparations was used to determine the differential cell count.
Histopathological analysis of the lungs
Immediately after BAL, the lungs are insufficient with 10% neutral buffered formalin (NBF) under pressure (aqueous column 30 cm). The lungs are removed and placed in 10% NBF containers. After fixing in 10% NBF for at least 24 hours, the lungs are processed in alcohol row and cast into wax. Longitudinal blocks are made from the lungs and a 2 μπι longitudinal incision is made at the level of the main bronchi for each animal. The sections are then stained with hematoxylin and eosin. Pathological evaluation of sections and classification of bronchiolar epithelium and submucosa will be performed.
Lung digestion procedure
In some studies, the lungs were digested alone to obtain tissue-localized inflammatory cells. In these studies, cells are obtained by washing the left side of the lungs with RPMI / FCS to remove blood from the cells immediately after BAL. In these studies, the right side of the lungs is insufficient and fixed with buffered formalin for histopathological analysis. The lung tissue to be digested is standardized in animals by withdrawing 300 mg of a portion of the lung tissue followed by collagenase digestion. This will release the cells from the lung tissue and allow them to be recovered. Total and differential cell counts are performed in the cells thus obtained.
289
Results (i) After antigen inhalation, there was a significant increase in the number of eosinophils and neutrophils in the untreated groups. This was demonstrated by a significant increase in BAL and eosinophil and neutrophil counts after cleavage, and also based on histopathological scores.
(ii) No macrophage / monocyte cell counts were observed in BAL when challenged with antigen or with any drug treatment.
(iii) The compounds are capable of significantly inhibiting neutrophil and eosinophil infiltration 24 hours after antigen challenge compared to the untreated control group, as demonstrated by all three methods. The effective dose ranged from 3 to 100 mg / kg po
(iv) In a multiple dose study per day, there was a quantitatively similar inhibition of cell influx as a single dose study.
These results indicate that the compounds of the present invention have anti-inflammatory activity when administered to rats prophylactically in an antigen-induced leukocyte infiltration model.
Second Inhibition of antigen-induced airway inflammation - study once daily ip
Sensitization and stimulation procedure
Brown Norway rats are sensitized on days 0, 12 and 21 with ovalbumin (100 µg, ip) administered with aluminum hydroxide (100 mg, i.p). On day 30, rats are exposed to 1% ovalbumin aerosol for 30 minutes. The animals are then returned to the cages.
Dosing procedure
The test drug is administered ritoneally four times intrape290 instead of po. The dosing regimen was 30 minutes before stimulation and 2, 4 and 8 hours after stimulation by allergen inhalation.
Procedure for obtaining bronchoalveolar lavage fluid (BAL) hours after stimulation by antigen inhalation, cells are harvested from the airway lumen by bronchoalveolar lavage of sacrificed animals and the lungs are washed three times with 5 ml aliquots of RPMI / FCS. The wash fluid is left in the lungs for 30 seconds and then carefully removed. Three samples are pooled and total and differential white blood cell counts are measured in BAL samples. The ARGOS system was used to determine the total cell count and the light microscopy of the cytocentrifuged preparations after Wright-Giems staining was used to determine the differential cell count.
Histopathological analysis of the lungs
Immediately after BAL, the lungs are insufflated with 10% neutral buffered formalin (NBF) under pressure (30 cm water column). The lungs are removed and placed in 10% NBF containers. After fixation in 10% NBF min For 24 hours, the lungs are processed in alcohol and cast into wax. The longitudinal blocks are prepared and a 2 μη longitudinal incision is made at the level of the main bronchi for each animal. The sections are then stained with hematoxylin and eosin. Pathological evaluation of sections and classification of bronchiolar epithelium and submucosa will be performed.
Lung digestion procedure
In some studies, the lungs were digested alone to obtain tissue-localized inflammatory cells. In these studies, cells are obtained by washing the left lung with RPMI / FCS to remove blood from the cells immediately after BAL. In these studies, the right side of the lung is inadequate and fixed with buffered formalin for histopathological analysis. The lung tissue to be digested is standardized in animals by taking a 300 mg portion
291 Lung tissue and collagenase digestion. This will release the cells in the lung tissue and allow them to be recovered. Total and differential cell counts are performed in the cells thus obtained.
Results (i) After antigen inhalation, there was a significant increase in the number of eosinophils and neutrophils in the untreated groups. This was demonstrated by a significant increase in BAL and the number of eosinophils and neutrophils in BAL after cleavage, and also based on histopathological scores.
(ii) The compounds of the invention are capable of significantly inhibiting neutrophil and eosinophil infiltration 24 hours after antigen challenge compared to the untreated control group, as demonstrated by all three methods. The effective dose ranged from 3 to 100 mg / kg po
These results indicate that compounds of the present invention have anti-inflammatory activity when administered prophylactically in a rat model of antigen-induced leukocyte infiltration either orally or intraperitoneally.
Third Inhibition of acute antigen-induced bronchoconstriction in allergic rats
Sensitization and stimulation procedure
Brown Norway rats are sensibletized on days 0, 12 and 21 with ovalbumin (100 μς, ip) administered with aluminum hydroxide (100 mg, ip). On study day, rats are surgically prepared to measure pulmonary mechanics and ventilated mechanically. After equilibration for 5 minutes, the animals receive a bolus of ovalbumin (1 mg per rat). The animals are then monitored for 15 minutes and the maximum changes in baseline resistance are recorded in response to antigen stimulation.
Dosing procedure
292
The test drug is administered either after or ip 24 and 2 hours prior to iv injection of ovalbumin. The amount of compound administered in this study was 10 to 100 mg / kg po
The results
Following antigen stimulation, there was a significant increase in airway resistance to baseline in untreated and budesonide control animals. In contrast, the compounds of the present invention significantly inhibited antigen-induced bronchoconstriction.
The results indicate that the compounds of the present invention inhibit antigen-induced bronchoconstriction.
4th Inhibition of Sephadex-induced lung edema in rats and cytokine gene expression in allergic rats
Sephadex administration procedure
Male Sprague-Dawley rats (400 g) are dosed with vehicle (saline) or Sephadex (5 mg / kg) at a dose volume of 1 ml / kg under anesthesia with halothane (4% in oxygen for 3 minutes).
Administration procedure
The drug is administered 1 hour before and 5 hours after Sephadex it at a dose volume of 1 ml / kg.
Procedure for assessing edema at the end of the test hours after administration of Sephadex, animals are sacrificed with
Euthatal (1 ml / kg ip), heart and lung are removed en bloc.
The increase in fresh weight was used as an index of edema. The fresh weight is determined and corrected for 100 g of initial body weight.
RT-PCR procedure (measurement of cytokine gene expression)
293
RNA is isolated from lung tissue using guanidinium thiocyanate-phenol-chloroform extraction technique. RNA was reverse transcribed into cDNA using AMV reverse transcriptase. The cDNA for IL-5, IL-4, eotaxin, and GAPDH (control gene) is amplified by PCR using an oligonucleotide sequence synthesized (Gibco) from published sequences.<sup>1</sup>
The PCR reagents are overlaid with mineral oil and amplification is carried out for 25 to 35 cycles of denaturation at 95 ° C for 1 minute, annealing (priming) at 55 to 65 ° C for 1 minute, and extension at 72 ° C for 7 minutes. The PCR products, stained with ethidium bromide, were electrophoresed in 2% agarose gels to visualize the cDNA bands.
Bands of each target fragment are visualized by ultraviolet translumination and photographed. Photos are scanned on a densitometer and the integrated optical densities (OD x mm) of each band are calculated using imaging analysis software (Imagemaster, Pharmacia). For each animal, the amount of each cytokine PCR product is normalized to the amount of GAPDH PCR product.
Results (i) The dripping of Sephadex alone induced considerable edema (32%).
(ii) The compounds of the present invention inhibit dose-dependent edema at doses of 10, 30 and 100 mg / kg.
(iii) Sephadex caused an increase in the expression of Th-2 cytokines IL-4 and IL-5 together with CC chemokine eotaxin in the lung 24 hours after stimulation. There was a tendency to increase expression of IL-5 and eotaxin mRNA.
(iv) The compounds of the present invention inhibit L-4 mRNA expression in a dose-dependent manner.
294
The compounds of the present invention inhibit Sephadex-induced lung edema in rats which is associated with a reduction in IL-4 induction by Sephadex.
5th Inhibition of antigen-induced histamine release in allergic Brown-Norway rats
Sensitization and stimulation procedure
Brown-Norway rats are sensitized on days 0, 12 and 21 with ovalbumin (100 µg, ip) administered with aluminum hydroxide (100 mg, ip). On the study day, rats are surgically prepared for antigen infusion. After 5 minutes of equilibration, the animals receive a bolus of ovalbumin (1 mg per rat). Blood samples are taken 2 minutes after ovalbumin challenge and plasma histamine levels are measured using a histamine ELISA assay.
Dosing procedure
The test drug is administered ip 30 minutes before ovalbumin stimulation. Only one concentration of 30 mg / kg ip was used in this study
The results
Following antigen challenge, Syk kinase inhibitors significantly inhibited antigen-induced histamine release compared to the vehicle-only group.
These results indicate that the compounds of the present invention inhibit antigen-induced histamine release.
6th Inhibition of ED-1 + alveolar macrophages in rat lung tissue
Sensitization and stimulation procedure
Brown-Norway rats are sensitized on days 0, 12 and 21 with ovalbumin (100 µg, ip) administered with aluminum hydroxide (100 mg,
295
ip). On day 30, rats are exposed to 1% ovalbumin aerosol for 30 minutes. The animals are then returned to the cages.
Dosing procedure
The test drug is administered either after or ip 24 and 2 hours before the ovalbumin IV bolus injection. The amount of compound administered in this study ranges from 10 to 100 mg / kg po
ED-1 quantification procedure f
Alveolar macrophages are quantified after immunostaining with ED-1 on paraffin-fixed lung tissue sections.
Results (i) Ovalbumin stimulation resulted in a 10-fold increase in the number of ED-1 + macrophages in the alveoli.
(ii) Syk kinase inhibition greatly reduced the increase in the number of albumin-induced ED-1 alveolar macrophages in a dose-dependent manner.
Oral administration of the compounds of the invention will provide a dose-dependent reduction in ED-1 + alveolar macrophages upon ovalbumin stimulation.
7th Inhibition of antigen-induced airway neutrophil in Brown-Norway rats
Sensitization and stimulation procedure
Brown-Norway rats are sensitized on days 0, 12 and 21 with ovalbumin (100 μς, ip) administered with aluminum hydroxide (100 mg,
ip). On day 30, rats are exposed to 1% ovalbumin aerosol for 30 minutes. The animals are then returned to the cages.
Dosing procedure
296 an hour prior to antigen challenge, rats are dosed orally. The amount of compound administered in this study ranges from 10 to 100 mg / kg po
Cell analysis procedure hours post-stimulation, cells are obtained from the airway lumen by bronchoalveolar lavage (RPMI / FCS as previously described). Immediately after flushing, the lungs are rinsed with RPMI / FCS to remove accumulated blood cells. 300 mg of tissue is collected and cells are harvested by enzymatic digestion (collagenase). Differential cell counts were performed by light microscopy of the preparations after centrifugation and staining according to Wright-Giemsa.
Results (i) A significant increase in po was observed 4 hours after antigen challenge I read neutrophils in both BAL and lung tissue.
(ii) The compounds of the present invention significantly suppressed ovalbumin-induced increase in neutrophil count in BAL but not in lung tissue.
Contents13257
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| 0004993 | United Kingdom | W | |
| 0004993 | United Kingdom | W | |
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Numbers
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- 9012002
- Publication, EPODOC
- SK9012002
- Application
- 9012002
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- Application, EPODOC
- SK20020000901
Titles
- English
- Azaindole derivatives, use thereof and pharmaceutical composition containing the same
Classification
- CPC, 24
- A61K31/4985
- C07D471/04
- A61K31/437
- C07D487/04
- A61P1/00
- A61P1/04
- A61P11/00
- A61P11/02
- A61P11/06
- A61P17/06
- A61P19/02
- A61P19/06
- A61P25/28
- A61P27/14
- A61P29/00
- A61P35/00
- A61P35/02
- A61P37/02
- A61P37/06
- A61P37/08
- A61P43/00
- A61P9/10
- A61P9/14
- A61P3/10
- IPC, 25
- A61K31 437
- A61K31 4985
- A61K31 5377
- A61P1 04
- A61P3 10
- A61P9 10
- A61P9 14
- A61P11 00
- A61P11 02
- A61P11 06
- A61P17 06
- A61P19 02
- A61P19 06
- A61P25 28
- A61P27 14
- A61P29 00
- A61P35 00
- A61P35 02
- A61P37 02
- A61P37 06
- A61P37 08
- A61P43 00
- C07D471 04
- C07D487 04
- C07D519 00
