Azaindoles

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CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -1AZAINDOLES This invention is directed to substituted azaindoles, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in the treatment of disease states capable of being modulated by the inhibition of the protein kinases.

Protein kinases participate in the signalling events which control the activation, growth and differentiation of cells in response to extracellular mediators and to changes in the environment.

In general, these kinases fall into several groups; those which preferentially phosphorylate serine and/or threonine residues and those which preferentially phosphorylate tyrosine residues [S.K.Hanks and T.Hunter, FASEB. J., 1995, 9, pages 576-596].

The serine/threonine kinases include for example, protein kinase C isoforms [A.C.Newton, J.

Biol.

Chem., 1995, 270, pages 28495-28498] and a group of cyclin-dependent kinases such as cdc2 [J.Pines, Trends in Biochemical Sciences, 1995, 18, pages 195-197].

The tyrosine kinases include membranespanning growth factor receptors such as the epidermal growth factor receptor [S.Iwashita and M.Kobayashi, Cellular Signalling, 1992, 4, pages 123-132], and cytosolic nonreceptor kinases such as p56tck, p59fYn, ZAP-70 and csk kinases [C.Chan et. al., Ann.

Rev.

Immunol., 1994,12, pages 555-592].

Inappropriately high protein kinase activity has been implicated in many diseases resulting from abnormal cellular function.

This might arise either directly or indirectly, for example by failure of the proper control mechanisms for the kinase, related for example to mutation, overexpression or inappropriate activation of the enzyme; or by over- or underproduction of cytokines or growth factors also participating in the transduction of signals upstream or downstream of the kinase.

In all of these instances, selective inhibition of the action of the kinase might be expected to have a beneficial effect.

Syk is a 72-kDa cytoplasmic protein tyrosine kinase that is expressed in a variety of hematopoietic cells and is an essential element in several cascades that couple antigen receptors to cellular responses.

Thus, Syk plays a pivotal role in signalling of the high affinity IgE receptor, FcER1, in mast cells and in receptor antigen signalling in T and B lymphocytes.

The signal transduction pathways present in mast, T and B cells have common features.

The ligand binding domain of the receptor lacks intrinsic tyrosine kinase activity.

However, they interact with transducing subunits that contain immunoreceptor tyrosine based activation motifs (ITAMs) [M.Reth, Nature, 1989, 338, pages 383-384].

These motifs are present in both the [3 and 7 subunits of the Fc&R1, in the a-subunit the of T cell receptor (TCR) and in the IgGa and IgG R CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -2subunits of the B cell receptor (BCR). [N.S.van Oers and A.Weiss, Seminars in Immunology, 1995, 7, pages 227-236] Upon binding of antigen and multimerization, the ITAM residues are phosphorylated by protein tyrosine kinases of the Src family.

Syk belongs to a unique class of tyrosine kinases that have two tandem Src homology 2 (SH2) domains and a C terminal catalytic domain.

These SH2 domains bind with high affinity to ITAMs and this SH2 mediated association of Syk with an activated receptor stimulates Syk kinase activity and localises Syk to the plasma membrane.

In Syk deficient mice, mast cell degranulation is inhibited, suggesting that this is an important target for the development of mast cell stabilising agents [P.S.Costello, Oncogene, 1996, 13, pages 2595-2605].

Similar studies have demonstrated a critical role for Syk in SCR and TCR signalling [A.M.Cheng, Nature, 1995, 378, pages 303-306, (1995) and D.H.Chu et al., Immunological Reviews, 1998, 165, pages 167-180].

Syk also appears to be involved in eosinophil survival in response to IL-5 and GM-CSF [S.Yousefi et al., J.

Exp.

Med., 1996,183, pages 1407-1414].

Despite the key role of Syk in mast cell, SCR and T cell signalling, little is known about the mechanism by which Syk transmits downstream effectors.

Two adaptor proteins, BLNK (B cell Linker protein, SLP-65) and SLP-76 have been shown to be substrates of Syk in B cells and mast cells respectively and have been postulated to interface Syk with downstream effectors [M.Ishiai et al., Immunity, 1999, 10, pages 117-125 and L.R.HendricksTaylor et al., J.Biol.

Chem, 1997, 272, pages 1363-13671.

In addition Syk appears to play an important role in the CD40 signalling pathway, which plays an important role in B cell proliferation [M.Faris et al., J.Exp.

Med., 1994,179, pages 1923-1931].

Syk is further involved in the activation of platelets stimulated via the lowaffinity IgG receptor (Fc gamma-RIIA) or stimulated by collagen [F.Yanaga et al., Biochem. J., 1995, 311, (Pt. 2) pages 471-4781.

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase involved in integrin-mediated signal transduction pathways. FAK colocalizes with integrins in focal contact sites and FAK activation and its tyrosine phosphorylation have been shown in many cell types to be dependent on integrins binding to their extracellular ligands.

Results from several studies support the hypothesis that FAK inhibitors could be useful in cancer treatment.

For example, FAK-deficient cells migrate poorly in response to chemotactic signals and overexpression of C-terminal domain of FAK blocks cell spreading as well as chemotactic migration (Sieg et al, J.

Cell Science,1999, 112, 2677-2691; Richardson A. and Parsons T., Cell, 1997, 97, 221-231) ; in addition, tumor cells treated with FAK antisense oligonucleotides lost their attachment and underwent apoptosis (Xu CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -3et al, Cell Growth Differ. 1996, 4, 413-418). FAK has been reported to be overexpressed in prostate, breast, thyroid, colon and lung cancers.

The level of expression of FAK is directly correlated with tumors demonstrating the most aggressive phenotype.

Angiogenesis or the formation of new blood vessels by sprouting from the preexisting vasculature is of central importance for embryonic development and organogenesis.

Abnormal enhanced neovascularization is observed in rheumatoid arthritis, diabetic retinopathy and during tumor development (Folkman, Nat.

Med., 1995, 1, 27-31.).

Angiogenesis is a complex multistage process which includes activation, migration, proliferation and survival of endothelial cells.

Extensive studies in the field of tumor angiogenesis in the past two decades have identified a number of therapeutic targets including kinases, proteases and integrins resulting in the discovery of many new anti-angiogenic agents, including KDR inhibitors some of which are currently under clinical evaluation (Jekunen, et al Cancer Treatment Rev.

1997, 23, 263-286.).

Angiogenesis inhibitors may be used in frontline, adjuvant and even preventive settings for the emergence or regrowth of malignancies.

Several proteins involved in chromosome segregation and spindle assembly have been identified in yeast and drosophila.

Disruption of these proteins results in chromosome missegregation and monopolar or disrupted spindles.

Among these kinases are the Ipll and aurora kinases from S.cerevisiae and drosophila respectively, which are required for centrosome separation and chromosome segregation.

One human homologue of yeast Ipl1 was recently cloned and characterized by different laboratories.

This kinase termed Aurora2, STK15 or BTAK belongs to the serine/threonine kinase family.

Bischoff et al showed that Aurora2 is oncogenic and is amplified in human colorectal cancers (EMBO J, 1998,17,3052-3065).

It has also been exemplified in cancers involving epithelial tumors such as breast cancer.

We have now found a novel group of substituted azaindoles, which have valuable pharmaceutical properties, in particular, the ability to inhibit protein kinases, more particularly, the ability to selectively inhibit Syk kinase.

35 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -4Thus, in one aspect, the present invention is directed to pharmaceutical compositions comprising compounds of general formula (I): R2 X R1 R3 C_"" bNr N H wherein:RI represents aryl or heteroaryl each optionally substituted by one or more groups selected from acyl, alkylenedioxy, alkenyl, alkenyloxy, alkynyl, aryl, cyano, halo, hydroxy, heteroaryl, heterocycloalkyl, nitro, R4, -C(=O)-NY1Y2, -C(=0)-OR5, -NY1Y2, -N(R6)-C(=O)R7, -N(R6)-C(=O)-NY3Y4, -N(R6)-C(=O)-OR7, -N(R6)-S02-R7, -N(R6)-S02-NY3Y4, -S02NY1Y2 and _Z2114;

R2 represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z1R8, -C(=O)NY3Y4, -C02R8, -NY3Y4, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4, -N(R6)-C(=O)-OR7, -N(R6)-S02-R7, -N(R6)-S02-NY3Y4 and one or more halogen atoms;

R3 represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, -C(=O)-OR5 or -C(=O)-NY3Y;

R4 represents alkyl, cycloalkyl or cycloalkylalkyl each optionally substituted by a substituent selected from aryl, cycloalkyl, cyano, halo, heteroaryl, heterocycloalkyl, CHO (or a 5-, 6- or 7-membered cyclic acetal derivative thereof), -C(=O)-NY1Y2, -C(=O)-OR5, Ny1y2, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4, -N(R6)-S02-R7, -N(R6)-S02-NY3Y4, -OR7 and one or more groups selected from hydroxy and carboxy;

R5 represents hydrogen, alkyl, alkenyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl;

R6 represents hydrogen or lower alkyl;

R7 represents alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -5R8 represents hydrogen or lower alkyl;

Xl represents N, CH, C-halo, C-CN, C-R7, C-NY3Y4, C-OH, C-Z2R7, C-C(=O)-OR5, C-C(=O)-NY3Y4, C-N(R8)-C(=O)-R7, C-S02-NY3Y4, C-N(R8)-S02- R7, C-alkenyl, Calkynyl or C-NO2;

Y1 and y2 are independently hydrogen, alkenyl, aryl, cycloalkyl, heteroaryl or alkyl optionally substituted by one or more groups selected from aryl, halo, heteroaryl, hydroxy, -C(=O)-NY3y4, -C(=O)-OR5, -NY3Y4, -N(R6)-C(=O)-R7, -N(R6)-C(=O)-NY3Y4, -N(R6)-S02-R7, -N(R6)-SO2-NY3Y4 and -OR7; or the group -NY1Y2 may form a cyclic amine;

Y3 and y4 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, heteroaryl or heteroarylalkyl; or the group -NY3Y4 may form a cyclic amine;

Z1 represents 0 or S;

Z2 represents 0 or S(O)n;

n is zero or an integer 1 or 2;

and their corresponding N-oxides, and their prodrugs, and their acid bioisosteres; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and their prodrugs, and their acid bioisosteres; together with one or more pharmaceutically acceptable carriers or excipients.

In another aspect, the invention concerns the compounds of formula (1) as defined above, but excluding the compounds 2-phenyl-lH-pyrrolo[2,3-b]pyridine, 2-(4-bromo-phenyl)3-methyl-lHpyrrolo[2,3-b]pyridine, 4-(3-methyl-lH-pyrrolo[2,3-b]pyridin-2-yl)-benzoic acid methyl ester, 2-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine, 2-(4-methoxy-phenyl)-1Hpyrrolo[2,3-b]pyridine, 5-methyl-2-phenyl-IH-pyrrolo[2,3-b]pyridine, 4-methyl-2-phenyl-lH-pyrrolo[2,3b]pyridine, 2-pyridin-3-yl-lH-pyrrolo[2,3-b]pyridine, 4-(3-methyl-lH-pyrrolo[2,3-b]pyridin2-yl)-benzoic acid, 2-(4-methoxy-phenyl)-3-methyl-lH-pyrrolo[2,3-b]pyridine, 2-(4-methylphenyl)-3-methyl1H-pyrrolo[2,3-b]pyridine, 4-(3-methyl-lH-pyrrolo[2,3-b]pyridin-2-yl)-benzoic acid isopropyl ester, 2-phenyl-3-methyl-lH-pyrrolo[2,3-b]pyridine, 5-bromo-2-phenyl-3-methyllH-pyrrolo[2,3b]pyridine, 6-chloro-2-phenyl-lH-pyrrolo[2,3-b]pyridine, 6-chloro-4-methyl-2phenyl-lHpyrrolo [2,3-b] pyridine, 4-methyl-2-phenyl-1H-pyrrolo [2,3-b] pyridin-3-ylcarboxaldehyde, 2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-acetonitrile, 2-phenyl-3-prop-l-enyl-lHpyrrolo[2,3b]pyridine, 4-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-carboxaldehyde, dimethyl-(2phenyl-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-amine, 2,2'-diphenyl-lH,1'H[3,3']bi[pyrrolo[2,3b]pyridinyl], 2-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetamide, 3-allyl-2phenyl-lHpyrrolo[2,3-b] pyridine, (2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetonitrile, 2-phenyl-lH CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -6pyrrolo[2,3-b]pyridine-3-carbaldehyde, 3-morpholin-4-ylmethyl-2-phenyl-lHpyrrolo[2,3b]pyridine, N-[2-(2-phenyl-lH-pyrrolo[2,3-b]pyridin-3-yl)-ethyl]-acetamide, 6phenyl-5Hpyrrolo [2,3-b] pyrazine, 6-(4-methoxy-phenyl)-5H-pyrrolo [2,3-b] pyrazine, 6(4-chloro-phenyl)5H-pyrrolo[2,3-b]pyrazine, 6-(2-chloro-phenyl)-5H-pyrrolo[2,3-b]pyrazine, 3methyl-6-phenyl5H-pyrrolo[2,3-b]pyrazine, 2-methyl-6-phenyl-SH-pyrrolo[2,3-b]pyrazine and 7methyl-6phenyl-5H-pyrrolo [2,3-b] pyrazine.

In the present specification, the term "compounds of the invention", and equivalent expressions, are meant to embrace compounds of general formula (I) as hereinbefore described, which expression includes the prodrugs, the pharmaceutically acceptable salts, and the solvates, e.g.

hydrates, where the context so permits.

Similarly, reference to intermediates, whether or not they themselves are claimed, is meant to embrace their salts, and solvates, where the context so permits.

For the sake of clarity, particular instances when the context so permits are sometimes indicated in the text, but these instances are purely illustrative and it is not intended to exclude other instances when the context so permits.

As used above, and throughout the description of the invention, the following terms, unless otherwise indicated, shall be understood to have the following meanings: "Patient" includes both human and other mammals.

"Acid bioisostere" means a group which has chemical and physical similarities producing broadly similar biological properties to a carboxy group (see Lipinski, Annual Reports in Medicinal Chemistry, 1986,21,p283 "Bioisosterism In Drug Design"; Yun, Hwahak Sekye, 1993, 33, pages 576-579 "Application Of Bioisosterism To New Drug Design"; Zhao, Huaxue Tongbao, 1995, pages 34-38 "Bioisosteric Replacement And Development Of Lead Compounds In Drug Design"; Graham, Theochem, 1995,343, pages 105-109 "Theoretical Studies Applied To Drug Design:ab initio Electronic Distributions In Bioisosteres").

Examples of suitable acid bioisosteres include: -C(=O)-NHOH, -C(=O)-CH2OH, -C(=O)-CH2SH, -C(=O)-NH-CN, sulfo, phosphono, alkylsulfonylcarbamoyl, tetrazolyl, arylsulfonylcarbamoyl, heteroarylsulfonylcarbamoyl, N-methoxycarbamoyl, 3-hydroxy-3-cyclobutene-1,2dione, 3,5dioxo-1,2,4-oxadiazolidinyl or heterocyclic phenols such as 3hydroxyisoxazolyl and 3-hydoxy-l-methylpyrazolyl.

"Acyl" means an H-CO- or alkyl-CO- group in which the alkyl group is as described herein.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -7"Acylamino" is an acyl-NH- group wherein acyl is as defined herein.

"Alkenyl" means an aliphatic hydrocarbon group containing a carbon-carbon double bond and which may be straight or branched having about 2 to about 15 carbon atoms in the chain.

Preferred alkenyl groups have 2 to about 12 carbon atoms in the chain; and more preferably 2 to about 6 carbon atoms (e.g. 2 to 4 carbon atoms) in the chain. "Branched," as used herein and throughout the text, means that one or more lower alkyl groups such as methyl, ethyl or propyl are attached to a linear chain; here a linear alkenyl chain. "Lower alkenyl" means about 2 to about 4 carbon atoms in the chain, which may be straight or branched.

Exemplary alkenyl groups include ethenyl, propenyl, n-butenyl, i-butenyl, 3-methylbut-2-enyl, npentenyl, heptenyl, octenyl, cyclohexylbutenyl and decenyl.

"Alkenyloxy" is an alkenyl-O- group wherein alkenyl is as defined above.

Exemplary alkenyloxy groups include allyloxy.

"Alkoxy" means an alkyl-O- group in which the alkyl group is as described herein.

Exemplary alkoxy groups include difluoromethoxy, methoxy, trifluoromethoxy, ethoxy, npropoxy, i-propoxy, n-butoxy and heptoxy.

"Alkoxycarbonyl" means an alkyl-O-CO- group in which the alkyl group is as described herein.

Exemplary alkoxycarbonyl groups include methoxy- and ethoxycarbonyl.

"Alkyl" means, unless otherwise specified, an aliphatic hydrocarbon group which may be straight or branched chain having about 1 to about 15 carbon atoms in the chain, optionally substituted by one or more halogen atoms.

Particular alkyl groups have from 1 to about 6 carbon atoms. "Lower alkyl" as a group or part of a lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl group means unless otherwise specified, an aliphatic hydrocarbon group which may be a straight or branched chain having 1 to about 4 carbon atoms in the chain.

Exemplary alkyl groups include methyl, ethyl, n-propyl, ipropyl, n-butyl, s-butyl, t-butyl, n-pentyl, 3-pentyl, heptyl, octyl, nonyl, decyl and dodecyl.

Exemplary alkyl groups substituted by one or more halogen atoms include trifluoromethyl.

"Alkylene" means an aliphatic bivalent radical derived from a straight or branched alkyl group, in which the alkyl group is as described herein.

Exemplary akylene radicals include methylene, ethylene and trimethylene.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -8"Alkylenedioxy" means an -O-alkylene-O- group in which alkylene is as defined above.

Exemplary alkylenedioxy groups include methylenedioxy and ethylenedioxy.

"Alkylsulfinyl" means an alkyl-SO- group in which the alkyl group is as previously described.

Preferred alkylsulfinyl groups are those in which the alkyl group is C14alkyl.

"Alkylsulfonyl" means an alkyl-S02- group in which the alkyl group is as previously described.

Preferred alkylsulfonyl groups are those in which the alkyl group is C14alkyl.

"Alkylsulfonylcarbamoyl" means an alkyl-S02-NH-C(=0)- group in which the alkyl group is as previously described.

Preferred alkylsulfonylcarbamoyl groups are those in which the alkyl group is C14alkyl.

"Alkylthio" means an alkyl-S- group in which the alkyl group is as previously described.

Exemplary alkylthio groups include methylthio, ethylthio, isopropylthio and heptylthio.

"Alkynyl" means an aliphatic hydrocarbon group containing a carbon-carbon triple bond and which group may be a straight or branched chain having about 2 to about 15 carbon atoms in the chain.

Preferred alkynyl groups have 2 to about 12 carbon atoms in the chain;

and more preferably 2 to about 6 carbon atoms (e.g. 2 to 4 carbon atoms) in the chain.

Exemplary alkynyl groups include ethynyl, propynyl, n-butynyl, i-butynyl, 3-methylbut-2-ynyl, and n-pentynyl.

"Aroyl" means an aryl-CO- group in which the aryl group is as described herein.

Exemplary aroyl groups include benzoyl and 1- and 2-naphthoyl.

"Aroylamino" is an aroyl-NH- group wherein aroyl is as previously defined.

"Aryl" as a group or part of a group denotes: (i) an optionally substituted monocyclic or multicyclic aromatic carbocyclic moiety of about 6 to about 14 carbon atoms, such as phenyl or naphthyl; or (ii) an optionally substituted partially saturated multicyclic aromatic carbocyclic moiety in which an aryl and a cycloalkyl or cycloalkenyl group are fused together to form a cyclic structure, such as a tetrahydronaphthyl, indenyl or indanyl ring.

Except where otherwise defined, aryl groups may be substituted with one or more aryl group substituents, which may be the same or different, where "aryl group substituent" includes, for example, acyl, acylamino, alkoxy, alkoxycarbonyl, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, alkylthio, aroyl, aroylamino, CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -9aryl, arylalkyloxy, arylalkyloxycarbonyl, arylalkylthio, aryloxy, aryloxycarbonyl, arylsulfinyl, arylsulfonyl, arylthio, carboxy (or an acid bioisostere), cyano, halo, heteroaroyl, heteroaryl, heteroarylalkyloxy, heteroaroylamino, heteroaryloxy, hydroxy, nitro, trifluoromethyl, -NY3y4, -CONY3y4, -S02Ny3y4, -NY3-C(=O)alkyl, -NY3S02alkyl or alkyl optionally substituted with aryl, heteroaryl, hydroxy, or -NY3y4.

"Arylalkyl" means an aryl-alkyl- group in which the aryl and alkyl moieties are as previously described.

Preferred arylalkyl groups contain a C14alkyl moiety.

Exemplary arylalkyl groups include benzyl, 2-phenethyl and naphthlenemethyl.

"Arylalkyloxy" means an arylalkyl-O- group in which the arylalkyl groups is as previously described.

Exemplary arylalkyloxy groups include benzyloxy and 1- or 2naphthalenemethoxy.

"Arylalkyloxycarbonyl" means an arylalkyl-O-CO- group in which the arylalkyl groups is as previously described.

An exemplary arylalkyloxycarbonyl group is benzyloxycarbonyl.

"Arylalkylthio" means an arylalkyl-S- group in which the arylalkyl group is as previously described.

An exemplary arylalkylthio group is benzylthio.

"Aryloxy" means an aryl-O- group in which the aryl group is as previously described.

Exemplary aryloxy groups include phenoxy and naphthoxy, each optionally substituted.

"Aryloxycarbonyl" means an aryl-O-C(=O)- group in which the aryl group is as previously described.

Exemplary aryloxycarbonyl groups include phenoxycarbonyl and naphthoxycarbonyl.

"Arylsulfinyl" means an aryl-SO- group in which the aryl group is as previously described.

"Arylsulfonyl" means an aryl-S02- group in which the aryl group is as previously described.

"Arylsulfonylcarbamoyl" means an aryl-S02-NH-C(=O)- group in which the aryl group is as previously described.

"Arylthio" means an aryl-S- group in which the aryl group is as previously described.

Exemplary arylthio groups include phenylthio and naphthylthio.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -10"Azaheteroaryl" means an aromatic carbocyclic moiety of about 5 to about 10 ring members in which one of the ring members is nitrogen and the other ring members are selected from carbon, oxygen, sulfur, and nitrogen.

Examples of azaheteroaryl groups include benzimidazolyl, imidazolyl, indazolinyl, indolyl, isoquinolinyl, pyridyl, pyrimidinyl, pyrrolyl, quinolinyl, quinazolinyl and tetrahydroindolizinyl.

"Cyclic amine" means a 3 to 8 membered monocyclic cycloalkyl ring system wherein one of the ring carbon atoms is replaced by nitrogen and which (i) may also contain a further heteroatom-containing group selected from 0, S, SO2, or NY7 (where Y7 is hydrogen, alkyl, aryl, arylalkyl, -C(=O)-R7, -C(=O)-OR7 or -S02R7); and (ii) may be fused to additional aryl (e.g. phenyl), heteroaryl (e.g. pyridyl), heterocycloalkyl or cycloalkyl rings to form a bicyclic or tricyclic ring system.

Exemplary cyclic amines include pyrrolidine, piperidine, morpholine, piperazine, indoline, pyrindoline, tetrahydroquinoline and the like groups.

"Cycloalkenyl" means a non-aromatic monocyclic or multicyclic ring system containing at least one carbon-carbon double bond and having about 3 to about 10 carbon atoms.

Exemplary monocyclic cycloalkenyl rings include cyclopentenyl, cyclohexenyl and cycloheptenyl.

"Cycloalkyl" means a saturated monocyclic or bicyclic ring system of about 3 to about 10 carbon atoms, optionally substituted by oxo.

Exemplary monocyclic cycloalkyl rings include C3_8cycloalkyl rings such as cyclopropyl, cyclopentyl, cyclohexyl and cycloheptyl.

"Cycloalkylalkyl" means a cycloalkyl-alkyl- group in which the cycloalkyl and alkyl moieties are as previously described.

Exemplary monocyclic cycloalkylalkyl groups include cyclopropylmethyl, cyclopentylmethyl, cyclohexylmethyl and cycloheptylmethyl.

"Halo" or "halogen" means fluoro, chloro, bromo, or iodo.

Preferred are fluoro and chloro.

"Heteroaroyl" means a heteroaryl-C(=O)- group in which the heteroaryl group is as described herein.

Exemplary heteroaryl groups include pyridylcarbonyl.

"Heteroaroylamino" means a heteroaroyl-NH- group in which the heteroaryl moiety is as previously described.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -11"Heteroaryl" as a group or part of a group denotes: (i) an optionally substituted aromatic monocyclic or multicyclic organic moiety of about 5 to about 10 ring members in which one or more of the ring members is/are element(s) other than carbon, for example nitrogen, oxygen or sulfur (examples of such groups include benzimidazolyl, benzthiazolyl, furyl, imidazolyl, indolyl, indolizinyl, isoxazolyl, isoquinolinyl, isothiazolyl, oxadiazolyl, pyrazinyl, pyridazinyl, pyrazolyl, pyridyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolinyl, 1,3,4-thiadiazolyl, thiazolyl, thienyl and triazolyl groups, optionally substituted by one or more aryl group substituents as defined above except where otherwise defined); (ii) an optionally substituted partially saturated multicyclic heterocarbocyclic moiety in which a heteroaryl and a cycloalkyl or cycloalkenyl group are fused together to form a cyclic structure (examples of such groups include pyrindanyl groups, optionally substituted by one or more "aryl group substituents" as defined above, except where otherwise defined).

Optional substituents include one or more "aryl group substituents" as defined above, except where otherwise defined.

"Heteroarylalkyl" means a heteroaryl-alkyl- group in which the heteroaryl and alkyl moieties are as previously described.

Preferred heteroarylalkyl groups contain a C1_4alkyl moiety.

Exemplary heteroarylalkyl groups include pyridylmethyl.

"Heteroarylalkyloxy" means an heteroarylalkyl-O- group in which the heteroarylalkyl group is as previously described.

Exemplary heteroaryloxy groups include optionally substituted pyridylmethoxy.

"Heteroaryloxy" means an heteroaryl-O- group in which the heteroaryl group is as previously described.

Exemplary heteroaryloxy groups include optionally substituted pyridyloxy.

"Heteroarylsulfonylcarbamoyl" means a heteroaryl-S02-NH-C(=O)- group in which the heteroaryl group is as previously described.

"Heterocycloalkyl" means: (i) a cycloalkyl group of about 3 to 7 ring members which contains one or more heteroatoms or heteroatom-containing groups selected from 0, S and NY7 and mat be optionally substituted by oxo; (ii) a partially saturated multicyclic heterocarbocyclic moiety in which an aryl (or heteroaryl) ring, each optionally substituted by one or more "aryl group substituents," and a heterocycloalkyl group are fused together to form a cyclic structure.

(Examples of such groups include chromanyl, dihydrobenzofuranyl, indolinyl and pyrindolinyl groups).

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -12"Heterocycloalkylalkyl" means a heterocycloalkyl-alkyl- group in which the heterocycloalkyl and alkyl moieties are as previously described.

"Prodrug" means a compound which is convertible in vivo by metabolic means (e.g. by hydrolysis) to a compound of formula (1), including N-oxides thereof.

For example an ester of a compound of formula (I) containing a hydroxy group may be convertible by hydrolysis in vivo to the parent molecule.

Alternatively, an ester of a compound of formula (I) containing a carboxy group may be convertible by hydrolysis in vivo to the parent molecule.

Suitable esters of compounds of formula (1) containing a hydroxy group are, for example acetates, citrates, lactates, tartrates, malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-0-hydroxynaphthoates, gentisates, isethionates, di-p-toluoyltartrates, methanesulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, cyclohexylsulfamates and quinates.

Suitable esters of compounds of formula (1) containing a carboxy group are, for example, those described by F.J.Leinweber, Drug Metab.

Res., 1987,18, page 379.

Suitable esters of compounds of formula (I) containing both a carboxy group and a hydroxy group within the moiety -L1-Y include lactones formed by loss of water between said carboxy and hydroxy groups.

Examples of such lactones include caprolactones and butyrolactones.

An especially useful class of esters of compounds of formula (1) containing a hydroxy group, may be formed from acid moieties selected from those described by Bundgaard et.

al., J.

Med.

Chem., 1989, 32 , page 2503-2507, and include substituted (aminomethyl)-benzoates, for example dialkylamino-methylbenzoates in which the two alkyl groups may be joined together and/or interrupted by an oxygen atom or by an optionally substituted nitrogen atom, e.g. an alkylated nitrogen atom, more especially (morpholino-methyl)benzoates, e.g. 3- or 4-(morpholinomethyl)-benzoates, and (4-alkylpiperazin-1-yl)benzoates, e.g. 3- or 4-(4-alkylpiperazin-1-yl)benzoates.

Where the compound of the invention contains a carboxy group, or a sufficiently acidic bioisostere, base addition salts may be formed and are simply a more convenient form for use; in practice, use of the salt form inherently amounts to use of the free acid form.

The bases which can be used to prepare the base addition salts include preferably those which produce, when combined with the free acid, pharmaceutically acceptable salts, that is, salts whose cations are CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -13non-toxic to the patient in pharmaceutical doses of the salts, so that the beneficial inhibitory effects inherent in the free base are not vitiated by side effects ascribable to the cations.

Pharmaceutically acceptable salts, including those derived from alkali and alkaline earth metal salts, within the scope of the invention include those derived from the following bases: sodium hydride, sodium hydroxide, potassium hydroxide, calcium hydroxide, aluminium hydroxide, lithium hydroxide, magnesium hydroxide, zinc hydroxide, ammonia, ethylenediamine, N-methylglucamine, lysine, arginine, ornithine, choline, N,N'-dibenzylethylenediamine, chloroprocaine, diethanolamine, procaine, N-benzylphenethylamine, diethylamine, piperazine, tris(hydroxymethyl)aminomethane, tetramethylammonium hydroxide, and the like.

Some of the compounds of the present invention are basic, and such compounds are useful in the form of the free base or in the form of a pharmaceutically acceptable acid addition salt thereof.

Acid addition salts are a more convenient form for use; and in practice, use of the salt form inherently amounts to use of the free base form.

The acids which can be used to prepare the acid addition salts include preferably those which produce, when combined with the free base, pharmaceutically acceptable salts, that is, salts whose anions are non-toxic to the patient in pharmaceutical doses of the salts, so that the beneficial inhibitory effects inherent in the free base are not vitiated by side effects ascribable to the anions.

Although pharmaceutically acceptable salts of said basic compounds are preferred, all acid addition salts are useful as sources of the free base form even if the particular salt, per se, is desired only as an intermediate product as, for example, when the salt is formed only for purposes of purification, and identification, or when it is used as intermediate in preparing a pharmaceutically acceptable salt by ion exchange procedures.

Pharmaceutically acceptable salts within the scope of the invention include those derived from mineral acids and organic acids, and include hydrohalides, e.g.

hydrochlorides and hydrobromides, sulfates, phosphates, nitrates, sulfamates, acetates, citrates, lactates, tartrates, malonates, oxalates, salicylates, propionates, succinates, fumarates, maleates, methylene-bis-b-hydroxynaphthoates, gentisates, isethionates, di-ptoluoyltartrates, methane-sulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, cyclohexylsulfamates and quinates.

As well as being useful in themselves as active compounds, salts of compounds of the invention are useful for the purposes of purification of the compounds, for-example by exploitation of the solubility differences between the salts and the parent compounds, side products and/or starting materials by techniques well known to those skilled in the art.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -14With reference to formula (I) above, the following are particular and preferred groupings:

R1 may particularly represent optionally substituted heteroaryl, especially optionally substituted azaheteroaryl.

Exemplary optionally substituted azaheteroaryls include indolyl, furanyl, pyridyl, pyrrolyl, pyrazolyl, quinolinyl, isoquinolinyl, imidazolyl, indazolyl, indolizinyl, tetrahydroindolizinyl and indazolinyl.

Optional substituents include one or more groups selected from alkylenedioxy, alkenyl, alkenyloxy, aryl, carboxy (or an acid bioisostere), cyano, halo, hydroxy, heteroaryl, heterocycloalkyl, R4, -C(=O)-R4, -C(=O)-NY1Y2, -NY1Y2 and -OR4. R1 more preferably represents optionally substituted indolyl, optionally substituted indolizinyl or optionally substituted pyrrolyl and is more especially optionally substituted indol-3-yl, indolizin-1-yl or optionally substituted pyrrol-3-yl.

RI may also particularly represent optionally substituted aryl, especially optionally substituted phenyl.

Optional substituents include one or more groups selected from alkylenedioxy, halo, R4, -NY1Y2 and -OR4. R1 still more preferably represents 4-substituted phenyl, more especially 4-tertiarybutylphenyl, R2 may particularly represent hydrogen.

R2 may also particularly represent halo.

R2 may also particularly represent lower alkyl optionally substituted by carboxy, cyano, halo, hydroxy, tetrazolyl, or -CONY3y4.

R2 may also particularly represent lower alkenyl.

R3 may particularly represent hydrogen.

R3 may also particularly represent optionally substituted aryl, especially optionally substituted phenyl.

R3 may also particularly represent lower alkyl (e.g. methyl).

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -15X1 may particularly represent N.

X1 may also particularly represent CH.

X1 may also particularly represent C-lower alkoxy, especially C-OCH3.

X1 may also particularly represent C-aryl, especially C-phenyl.

Xl may also particularly represent C-halo, especially C-Cl.

X1 may also particularly represent C-CN.

It is to be understood that this invention covers all appropriate combinations of the particular and preferred groupings referred to herein.

A particular preferred group of compounds of the invention are compounds of formula (Ia):5 (R10, P 6 R2 4 1 7 R3 r\ N N N R9 H (la) in which R2, R3 and X1 are as hereinbefore defined; R9 is hydrogen, R4, alkenyl or heterocycloalkyl; R10 is alkenyloxy, carboxy (or an acid bioisostere), cyano, halo, hydroxy, heteroaryl, R4, -C(=O)-R4, -C(=O)-NYlY2, -OR4, -N(R6)-C(=O)-R7, -N(R6)-S02-R7 or -NYlY2; and p is zero, or an integer 1 or 2; and their prodrugs and pharmaceutically acceptable salts, and solvates (e.g. hydrates) of compounds of formula (Ia) and their prodrugs.

Compounds of formula (Ia) in which R2 represents hydrogen are preferred.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -16Compounds of formula (Ia) in which R3 is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen, are preferred.

Compounds of formula (Ia) in which XI is CH, C-lower alkoxy (e.g. C-OCH3), Caryl, (e.g.

C-phenyl), C-halo (e.g. C-Cl), C-CN or N are preferred.

Compounds of formula (Ia) in which R9 represents:

(i) hydrogen;

(ii) C1_4alkyl [e.g. -CH3 ];

(iii) CI-4alkyl substituted by hydroxy [e.g. -CH 2OH , -CH2CH2OH or -CH 2CH2CH2OH (iv) C1-4alkyl substituted by -N(R6)C(=O)-R7 [e.g. -CH2CH2CH2NHC (=O) CH3 ];

v C14alkYl substituted by -C(- =O)-NY1Y2 [e.g. -CH 2 -C (O) N O ]; or H2C CH2 (vi) cycloalkylalkyl substituted by hydroxy [e.g. - C -CH2 ] CH2OH are preferred.

Compounds of formula (Ia) in which R9 represents hydrogen or CH3 are especially preferred.

Compounds of formula (Ia) in which R10 represents:

(i) hydroxy;

(ii) -OR4 in which R4 is alkyl [e.g. -OCH3 ];

(iii) -OR4 in which R4 is alkyl or cycloalkylalkyl substituted by one or more hydroxy groups [e.g. -OCH2CH2OH , -OCH2CH2CH2OH , -OCH (CH3) CH2OH , H2C-CH2 -OCH2CH (OH) CH3 , -O- i -CH2 , -OCH (OH) CH2OH , or CH2OH -OCH2CH(OH)CH 2 OH ];

CA 02395593 2009-11-06 WO 01/47922 PCT/GBOO/04993 -17(iv) -OR4 in which R4 is alkyl substituted by one or more alkoxy groups [e.g.

-OCH (CH3) CH2OCH3 ];

(v) -OR4 in which R4 is alkyl or cycloalkyl substituted by one or more carboxy groups H2C CH2 [e.g. -OCH2CO2H, -OCH (CH3) CO2H or -0- i -CH2 CO2H H2C -CH 2 (vi) -OR4 in which R4 is cycloalkyl substituted by -C(=O)-NY1Y2 [e.g. -O- i CH2 or CONH2 H2C-CH2 -0- i -CH2 ];

CONHCH3 (vii) -N(R6)-C(=O)-R7 [e.g. -NHC (=O) CH3 ];

(viii) -CONY1Y2 [e.g. -CONH2 1 -CONHCH3, -CONHCH (CH2OH) 2 , -CONHCH2CH2OH , -CONHC (CH3) 2CE20H , -CONHCH2CH2OCH3 , 10. -CONHCH2CH2CO2H, -CONHCH2CH2CONH2 or -CONH\\ ];

' N (ix) carboxy (x) alkyl substituted by carboxy [e.g. -CH2CH2CO2H ];

N CH3 (xi) heteroaryl [e.g. --{~ or pyridyll;

N'O (xii) -C(=O)-R4 in which R4 is alkyl [e.g. -C (=O) -CH3 ]; or (xiii) tetrazolyl or N-methyltetrazolyl.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -18H2C-CH2 are preferred.

Compounds of formula (Ia) in which Rio represents -OCH3 , -O- 1 -CH2 I CH2OH H2C-CH2 H2C-CH2 -O- i -CH2 or -O- i -CH2 are especially preferred.

CONH2 CONH2 When p is 1, R10 is preferably attached to position 5 of the indolyl ring.

When p is 2, the R10 groups are preferably attached to positions 5 and 6 of the indolyl ring.

A preferred group of compounds of the invention are compounds of formula (Ia) in which:- R2 is hydrogen; R3 is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen; XI is CH, C-lower alkoxy [especially C-OCH31, C-aryl [especially Cphenyl], C-halo [especially C-Cl] or C-CN; R9 is (i) hydrogen, (ii) C14alkyl [e.g. -CH3 ], (iii) C14alkyl substituted by hydroxy [e.g. -CH 2OH,-CH 2 CH20H or -CH 2CH2CH2OH ], (iv) C1-4alkyl substituted by -N(R6)C(=O)-R7 [e.g. -CH2CH2CH2NHC (=O) CH3 ], (v) CI4alkyl substituted by -C(=O)-NYlY2 [e.g. -CH 2 C (=O) - ~; ] or (vi) cycloalkylalkyl H2C-CH2 substituted by hydroxy [e.g. -C-CH2 1; R10 is (i) hydroxy, (ii) -OR4 in which R4 is alkyl CH2OH [e.g. -OCH3 ], (iii) -OR4 in which R4 is alkyl or cycloalkylalkyl substituted by one or more hydroxy groups [e.g. -OCH2CH2OH , -OCH2CH2CH2OH , -OCH2CH(OH)CH 2 OH, H2C-CH2 -OCH2CH(OH)CH 3 , -OCH (CH3) CH2OH or -O- i -CH21 , (iv) -OR4 in which R4 is alkyl CH2OH substituted by one or more alkoxy groups [e.g. -OCH (CH3) CH2OCH3 ], (v) -OR4 in which R4 is alkyl or cycloalkyl substituted by one or more carboxy groups [e.g. -OCH2CO2H, CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -19H2C-CH2 -OCH (CH3) CO2H or -O- i -CH2 ], (vi) -OR4 in which R4 is cycloalkyl substituted by CO2H H2C-CH2 H2C-CH2 -C(=O)-NYlY2 [e.g. -O-C-CH2 or -O-C-CH2 ], (vii) -N(R6)-C(=O)-R7 [e.g.

I I CONH2 CONHCH3 -NHC (=O) CH3 ]; (viii) -CONY1Y2 [e.g. -CONH2 , -CONHCH3, -CONHCH (CH2OH) 2' -CONHCH2CH2OH , -CONHC (CH3) 2CH2OH , -CONHCH2CH2OCH3 , N -CONHCH2CH2CO2H , -CONHCH2CH2CONH2 or -CONH-C~ H ], (ix) carboxy, (x) N' N CH3 -'~r alkyl substituted by carboxy [e.g. -CH2CH2CO2H ], (xi) heteroaryl [e.g. --<~ or pyridyl], (xii) -C(=O)-R4 in which R4 is alkyl [e.g. -C (=O) -CH3 ] or (xii) tetrazolyl or Nmethyltetrazolyl; the R10 group is attached to position 5 of the indolyl ring when p is 1 and the R10 groups are attached to position 5 and 6 of the indolyl ring when p is 2;

and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and prodrugs.

A further preferred group of compounds of the invention are compounds of formula (Ia) in which:- R2 is hydrogen; R3 is hydrogen or lower alkyl (e.g. methyl), especially hydrogen; XI is N; R9 is (i) hydrogen, (ii) C14alkyl [e.g. -CH3 ], (iii) C14alkyl substituted by hydroxy [e.g. -CH 2OH,-CH 2 CH 2 OH or -CH 2CH2CH2OH ], (iv) C1-4alkyl substituted by -N(R6)C(=O)-R7 [e.g. -CH2CH2CH2NHC (=O) CH3 ], (v) C1-4alkyl substituted by -C(=O)-NY1Y2 [e.g. -CH 2 C (=O) - O ] or (vi) cycloalkylalkyl substituted by hydroxy H2C-CH2 [e.g. - C -CH2 ]; R10 is (i) hydroxy, (ii) -OR4 in which R4 is alkyl [e.g. OCH3 ], (iii) -OR4 in CH2OH CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -20which R4 is alkyl or cycloalkylalkyl substituted by one or more hydroxy groups [e.g.

-OCH2CH2OH , -OCH2CH2CH2OH , -OCH2CH (OH) CH2OH , -OCH2CH (OH) CH3 , H2C-CH2 -OCH (CH3) CH2OH or -O- i -CH21, (iv) -OR4 in which R4 is alkyl substituted by one or CH2OH more alkoxy groups [e.g. -OCH (CH3) CH2OCH31, (v) -OR4 in which R4 is alkyl or cycloalkyl substituted by one or more carboxy groups [e.g. -OCH2CO2H , -OCH (CH3) CO2H or H2C-CH2 -O-C-CH21, (vi) -OR4 in which R4 is cycloalkyl substituted by -C(=O)-NY1Y2 [e.g.

I CO2H H2C-CH2 H2C-CH2 -O-C-CH2 or -O-C-CH2 1, (vii) -N(R6)-C(=O)-R7 [e.g. -NHC (=O) CH31; (viii) I I CONH2 CONHCH3 -CONYIY2 [e.g. -CONH2 , -CONHCH3 , -CONHCH (CH2OH)2' -CONHCH2CH2OH , -CONHC (CH3) 2CH2OH , -CONHCH2CH2OCH3 , -CONHCH2CH2CO2H , N -CONHCH2CH2CONH2 or -CONH_- 1, (ix) carboxy, (x) alkyl substituted by carboxy N--NH N CH3 [e.g. -CH2CH2CO2H 1, (xi) heteroaryl [e.g. --~ or pyridyll, (xii) -C(=O)-R4 in which NCO R4 is alkyl [e.g. -C (=O) -CH 31 or (xii) tetrazolyl or N-methyltetrazolyl;

the R10 group is attached to position 5 of the indolyl ring when p is 1 and the R10 groups are attached to position 5 and 6 of the indolyl ring when p is 2; and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and prodrugs.

Another particular group of compounds of the invention are compounds of formula (Ib): CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -21(R10) P 6 R2 4 X 1 7 N R3 . :]~ I N \ R9 H (Ib) in which R2, R3, R9, R10, X1 and p are as hereinbefore defined, and their prodrugs and pharmaceutically acceptable salts, and solvates (e.g. hydrates) of compounds of formula (1b) and their prodrugs.

Compounds of formula (Ib) in which R2 represents hydrogen are preferred.

Compounds of formula (Ib) in which R3 is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen, are preferred.

Compounds of formula (Ib) in which X1 is CH, C-lower alkoxy (e.g. C-OCH3), Caryl, (e.g.

C-phenyl), C-halo (e.g. C-Cl), C-CN or N are preferred.

Compounds of formula (Ib) in which R9 represents hydrogen are preferred.

Compounds of formula (Ib) in which R9 represents C1_4alkyl [e.g. -CH3 ] are also preferred.

Compounds of formula (Ib) in which p is zero are preferred.

A preferred group of compounds of the invention are compounds of formula (Ib) in which:- R2 is hydrogen; R3 is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen; X1 is CH, C-lower alkoxy [especially C-OCH3], C-aryl [especially C-phenyl], C-halo [especially C-Cl] or C-CN; R9 is hydrogen or C1-4alkyl [e.g.

-CH3 ]; p is zero;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -22and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and prodrugs.

A further preferred group of compounds of the invention are compounds of formula (Ib) in which:- R2 is hydrogen; R3 is hydrogen or lower alkyl (e.g. methyl), especially hydrogen; X1 is N; R9 is hydrogen or C14alkyl [e.g. -CH3 ]; p is zero; and the corresponding Noxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and prodrugs.

Another particular group of compounds of the invention are compounds of formula (Ic):R2 X 4 (R10) P N 5 R3 \ s N 2 R H (Ic) in which R2, R3, R9, R10, XI and p are as hereinbefore defined, and their prodrugs and pharmaceutically acceptable salts, and solvates (e.g. hydrates) of compounds of formula (1c) and their prodrugs.

Compounds of formula (Ic) in which R2 represents hydrogen are preferred.

Compounds of formula (Ic) in which R3 is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen, are preferred.

Compounds of formula (Ic) in which X1 is CH, C-lower alkoxy (e.g. C-OCH3), Caryl, (e.g.

C-phenyl), C-halo (e.g. C-Cl), C-CN or N are preferred.

Compounds of formula (Ic) in which R9 represents C1-4alkyl [e.g. -CH3 ] are also preferred.

Compounds of formula (Ic) in which p is 1 are preferred.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -23Compounds of formula (Ic) in which R10 represents aryl [e.g. phenyl] are preferred.

R10 is preferably attached at position 4 of the pyrrole ring.

A preferred group of compounds of the invention are compounds of formula (Ic) in which:- R2 is hydrogen; R3 is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen; X1 is CH, C-lower alkoxy [especially C-OCH3], C-aryl [especially C-phenyl], C-halo [especially C-Cl] or C-CN; R9 is C1-4alkyl [e.g. -CH 3 ]; p is 1; R10 is aryl [e.g.

phenyl] and R10 is attached at position 4 of the pyrrole ring; and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g.

hydrates) of such compounds and their N-oxides and prodrugs. R3 is hydrogen, optionally substituted aryl (e.g.

phenyl) or lower alkyl (e.g. methyl), especially hydrogen; X1 is CH, C-lower alkoxy [especially C-OCH3], C-aryl [especially C-phenyl], C-halo [especially C-CI] or C-CN;

A further preferred group of compounds of the invention are compounds of formula (Ic) in which:- R2 is hydrogen; R3 is hydrogen; X1 is N; R9 is CI-4alkyl [e.g. -CH3 ];

p is 1; R10 is aryl [e.g. phenyl] and R10 is attached at position 4 of the pyrrole ring; and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g. hydrates) of such compounds and their N-oxides and prodrugs.

Another particular group of compounds of the invention are compounds of formula (Id):R2 X 6 5 (R' ) P R3 4 N N 2 3 H (Id) CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -24in which R2, R3, R10, X1 and p are as hereinbefore defined, and their prodrugs and pharmaceutically acceptable salts, and solvates (e.g. hydrates) of compounds of formula (Id) and their prodrugs.

Compounds of formula (Id) in which R2 represents hydrogen, lower alkyl (e.g.

methyl), lower alkyl substituted by -CONY3Y4 (e.g. -CH2CH2CONH2 or -CH2CH2CONHCH3), lower alkyl substituted by carboxy (e.g. -CH2CH2CO2H), lower alkyl substituted by tetrazolyl (e.g.

N-- NH -CH2CH < ~N ] or lower alkyl substituted by hydroxy [e.g. -CH2CH2 CH2OH] are preferred.

Compounds of formula (Id) in which R3 is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen, are preferred.

Compounds of formula (Id) in which XI is CH, C-lower alkoxy (e.g. C-OCH3), Caryl, (e.g.

C-phenyl), C-halo (e.g. C-Cl), C-CN or N are preferred.

Compounds of formula (Id) in which p is 1 are preferred.

Compounds of formula (Id) in which R10 represents alkyl [e.g. tertiarybutyll are preferred.

R10 is preferably attached at position 4.

A preferred group of compounds of the invention are compounds of formula (Id) in which:- R2 is hydrogen, lower alkyl (e.g. methyl), lower alkyl substituted by -CONY3Y4 (e.g.

-CH2CH2CONH2 or -CH2CH2CONHCH3), lower alkyl substituted by carboxy (e.g.

N--CH2CH2CO2H), lower alkyl substituted by tetrazolyl (e.g. -CH2 CH2 or lower alkyl substituted by hydroxy [e.g. -CH2CH2 CH2OH]; R3 is hydrogen, optionally substituted aryl (e.g. phenyl) or lower alkyl (e.g. methyl), especially hydrogen; X1 is CH, C-lower alkoxy [especially C-OCH3], C-aryl [especially C-phenyl], C-halo [especially C-Cl] or C-CN; p is 1; R10 is alkyl [e.g. tertiary-butyl] and R10 is attached at position 4; and the corresponding N-oxides, CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -25and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g.

hydrates) of such compounds and their N-oxides and prodrugs.

A further preferred group of compounds of the invention are compounds of'formula (Id) in which:- R2 is hydrogen, lower alkyl (e.g. methyl), lower alkyl substituted by CONY3Y4 (e.g.

-CH2CH2CONH2 or -CH2CH2CONHCH3), lower alkyl substituted by carboxy (e.g.

N--NH -CH2CH2CO2H), lower alkyl substituted by tetrazolyl (e.g. -CH 2 CH2 N ] or lower N alkyl substituted by hydroxy [e.g. -CH2CH2 CH2OH]; R3 is hydrogen; X1 is N; p is 1; R10 is alkyl [e.g. tertiary-butyl] and R10 is attached at position 4; and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates (e.g.

hydrates) of such compounds and their N-oxides and prodrugs.

Particular compounds of the invention of formula (Ia) are selected from the compounds formed by joining the carbon atom (C*) of one of the azaindoles fragments (Al to A28) shown in Table 1 to the carbon atom (*C) in the five membered ring of one of the fragments (Bl to B19) shown in Table 2, and joining the carbon atom (C*) of the phenyl ring in one of the fragments (B1 to B19) shown in Table 2 to the oxygen atom (*0) of one of the fragments (Cl to C19) depicted in Table 3.

Particular compounds of the invention of formula (Ia) are also selected from the compounds formed by joining the carbon atom (C*) of one of the azaindoles fragments (Al to A28) shown in Table 1 to the carbon atom (*C) in the five membered ring of one of the fragments (B1 to B19) shown in Table 2, and joining the carbon atom (C*) of the phenyl ring in one of the fragments (B1 to B19) shown in Table 2 to the carbon atom (*C) of one of the fragments (C20 to C44) depicted in Table 3.

Particular compounds of the invention of formula (Ia) are also selected from the compounds formed by joining the carbon atom (C*) of one of the azaindoles fragments (Al to A28) shown in Table 1 to the carbon atom (*C) in the five membered ring of one of the fragments (B1 to B19) shown in Table 2, and joining the carbon atom (C*) of the phenyl ring in one of the fragments (B1 to B19) shown in Table 2 to the nitrogen atom (*N) of the fragment (C45) or a hydrogen atom (*H, fragment (C46)) depicted in Table 3.

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -26Particular compounds of the invention of formula (Ib) are selected from the compounds formed by joining the carbon atom (C*) of one of the azaindoles fragments (Al to A28) shown in Table 1 to the carbon atom (*C) in the five membered ring of one of the indolizine fragments (B20 or B21) shown in Table 2, and joining the carbon atom (C*) in the six membered ring of one of the indolizine fragments (B20 or B21) shown in Table 2 to (i) the oxygen atom (*0) of one of the fragments (Cl to C19), (ii) the carbon atom (*C) of one of the fragments (C20 to C42), (iii) the nitrogen atom (*N) of the fragment (C45) or (iv) a hydrogen atom (*H, fragment (C46)) depicted in Table 3.

Particular compounds of the invention of formula (Ib) are also selected from the compounds formed by joining the carbon atom (C*) of one of the azaindoles fragments (Al to A28) shown in Table 1 to the carbon atom (*C) in the indolizine fragments (B22) shown in Table 2.

Particular compounds of the invention of formula (Ic) are selected from the compounds formed by joining the carbon atom (C*) of one of the azaindoles fragments (Al to A28) shown in Table 1 to the carbon atom (*C) in one of the pyrrole fragments (B23 to B32) shown in Table 2.

Particular compounds of the invention of formula (Id) are selected from the compounds formed by joining the carbon atom (C*) of one of the azaindoles fragments (A29 to A41) shown in Table 1 to the carbon atom (*C) in one of the fragments (B33 to B44) shown in Table 2.

TABLE 1 Al A2 Xc* C* N N N N H H A3 N A4 CF3 C C* N N C* N N H H CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -27A5 0 -~CH3 A6 0 I-ICF3 ~C* C* N N N N H H ` A7 A8 0 O N~S~l Nl-lH C* N N O H \~ C* N N H A9 O NHCH3 A10 O NH2 C* C* N N N N H H All I A12 O N\ 0 C C* N N N N H H A13 A14 L-L..CH1iIIITii1iiii"c * ~C* N N N N H H CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -28A15 A16 N N C C* N N N N H H A17 N A18 S \ \ C* NC* N N N H H A19 O A20 (0) N C* C* N N N N \ \ H H A21 i A22 N N C* N H N N H A23 O A24 N~ Nl-lH O C* C* N N N N H H CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -29A25 H A26 O~ ,NH2 OjS~N~ O O C* N N C * N N H H A27 F A28 C1 CKI C* C* N N N H H A29 CH3 A30 OH N C* N N I C* H N N H A31 CO2H A32 0 NH2 N N C* I C* N N H N N H A33 0 A34 0 NHCH3 N (CH 3)2 CN\ C* \ C* N I N N N H H CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -30A35 NN--- N A36 N 1\ I NH N NH N N C* N N N N H H A38 A37 'IN N ~p C* C* H C* C* N N N H H A39 O A40 p OH N H N C* \ N N C H N N H A41 O N H N C* N N H TABLE 2 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -31B1 C* B2 C* *cl *cl N CH3 H B3 C* B4 C* *clI N N CH2CH3 CH2OH B5 C* B6 C* *c *cll N N CH2CH2OH CH2CH2CH2OH C* B7 C* B8 l I _ / v / L I _ * *c *C N N CH2CH2CH2NH000H3 CH2 N ~L~ O B9 C* B10 C* / \ / *cll *cll N N O CH2 CH NH2 OH OH CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -32B11 C* B12 C* *cI *cl o N N CH 2 OH OZ:Z NCH OH B13 C* B14 C* cIl cll N N CH2OH OH B15 C* B16 C* *c) *cll _ ~N N Cl \ CH3 B17 C* B18 O C* *c~ - *c~ ~N H CH3 B19 B20 _C* C* *c I *C j-\ H CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -33B21 _C* B22 OC li-l", - )/ *C~ `:Z~ N / N CH3 CH2 0~1 N O B23 B24 *c *c `-N `-N B25 B26 N *C\\ *c -N N B27 B28 S O N N N C* *c \\ \\ N \LN ~-N B29 B30 S 0 NH2 N N C\\ *C ~` N N CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -34B31 B32 ~-N -N B33 B34 *C/ \ CMe3 *C/ \ OH B36 B35 0,- D B37 `-~ B38 * N O *C N co B38 \ B40 \ *C - N *C - \ B41 B42 *C/ \ O *C/ \ C-N B43 B44 O-/--OH * \ N\ C C/ O TABLE 3 C1 C2 *O-CH3 *O O HO C3 /OH C4 OH *O *O CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -35-5 *O C6 *0 HO HO C7 C8 *O *O -~=o H-N HO OH C9 OH C10 *O-H *0---)\",OH C11 C12 *0 *0-7 COOH HO C13 C14 *0 *0 MeO 0 N H C15 C16 *0 *0 CONH2 CONHCH3 C17 cis % *0 ---- N *O O O C19 OH C20 O *p *C-CH 3 HO C21 C22 *CH2 CH2-CO2H *CH2 CH2-CONH2 C23 0 C24 0 *C-NH-CH3 *C-NH-CH 2-CH2-CONH2 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -36C25 0 C26 III II *C-NH-CH 2-CH2-OCH3 *C-NH-CH2-CH2-CON (H) CH3 C27 S C28 0 \ ' *C-OH O 11 1-*C-NH C29 O 0 C30 0 11 * C-NH2 *C-NH HO OH C31 O 0 C32 0 11 * C-NH *C-NH /VNOH HO OH C33 O 0 C34 0 11 *C-NH *C-NH-CH 2-CH2-OH HO \-~OH C35 ,N C36 H *c \ N *C /NN N N-N \\ // N-N C37 C38 C~ C N C39 C40 *CI \N * \\ /N C41 C42 CH3 *CH2 NH-SO2-CH3 *C-OH CH3 C43 H C44 *C-OH *CH2 NH-CO-NHCH2CH3 CH3 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -37C45 C46 *H *NH 4 O Particularly preferred examples of fragments "A", "B", and "C" are illustrated below:

Al-B1-C1; Al-B1-C2; Al-B1-C3; Al-B1-C4; Al-B1-C5; Al-B1-C6;

Al-B1-C7; Al-B1-C8; Al-B1-C9; Al-BI-CIO; Al-B1-C11; Al-BI-C12;

Al-B1-C13; Al-B1-C14; Al-B1-C15; Al-B1-C16; Al-B1-C17; Al-B1-C18;

Al-B1-C19; Al-B1-C20; Al-Bl-C21; Al-B1-C22; AI-BI-C23; Al-B1-C24;

Al-B1-C25; AI-BI-C26; Al-B1-C27; Al-B1-C28; Al-B1-C29; Al-B1-C30;

Al-BI-C31; Al-Bl-C32; Al-B1-C33; Al-BI-C34; Al-B1-C35; Al-B1-C36;

Al-Bl-C37; AI-BI-C38; Al-B1-C39; Al-BI-C40; Al-B1-C41; Al-B1-C42;

Al-B1-C43; Al-B1-C44; Al-B1-C45; Al-B1-C46; A2-B1-C1; A2-Bl-C2;

A2-B1-C3; A2-B1-C4; A2-B1-C5; A2-B1-C6; A2-B1-C7; A2-B1-C8;

A2-B1-C9; A2-B1-C10; A2-B1-C11; A2-B1-C12; A2-B1-C13; A2-B1-C14;

A2-B1-C15; A2-B1-C16; A2-B1-C17; A2-B1-C18; A2-B1-C19; A2-B1-C20;

A2-B1-C21; A2-B1-C22; A2-B1-C23; A2-B1-C24; A2-B1-C25; A2-B1-C26;

A2-B1-C27; A2-B1-C28; A2-B1-C29; A2-B1-C30; A2-B1-C31; A2-B1-C32;

A2-B1-C33; A2-B1-C34; A2-B1-C35; A2-B1-C36; A2-B1-C37; A2-B1-C38;

A2-B1-C39; A2-B1-C40; A2-B1-C41; A2-B1-C42; A2-B1-C43; A2-B1-C44;

A2-B1-C45; A2-B1-C46; A3-B1-C1; A3-B1-C2; A3-B1-C3; A3-B1-C4;

A3-B1-C5; A3-B1-C6; A3-BI-C7; A3-B1-C8; A3-B1-C9; A3-B1-C10;

A3-B1-C11; A3-B1-C12; A3-B1-C13; A3-B1-C14; A3-B1-C15; A3-B1-C16;

A3-B1-C17; A3-B1-C18; A3-B1-C19; A3-B1-C20; A3-B1-C21; A3-B1-C22;

A3-B1-C23; A3-B1-C24; A3-B1-C25; A3-B1-C26; A3-B1-C27; A3-B1-C28;

A3-B1-C29; A3-B1-C30; A3-B1-C31; A3-B1-C32; A3-B1-C33; A3-B1-C34;

A3-B1-C35; A3-B1-C36; A3-B1-C37; A3-B1-C38; A3-B1-C39; A3-B1-C40;

A3-B1-C41; A3-B1-C42; A3-B1-C43; A3-B1-C44; A3-B1-C45; A3-B1-C46;

A4-B1-C1; A4-B1-C2; A4-B1-C3; A4-B1-C4; A4-B1-C5; A4-Bl-C6;

A4-B1-C7; A4-B1-C8; A4-B1-C9; A4-B1-C10; A4-B1-C11; A4-B1-C12;

A4-B1-C13; A4-B1-C14; A4-B1-C15; A4-B1-C16; A4-B1-C17; A4-B1-C18;

A4-B1-C19; A4-B1-C20; A4-B1-C21; A4-B1-C22; A4-B1-C23; A4-B1-C24;

A4-B1-C25; A4-B1-C26; A4-B1-C27; A4-B1-C28; A4-B1-C29; A4-B1-C30;

A4-B1-C31; A4-B1-C32; A4-B1-C33; A4-B1-C34; A4-B1-C35; A4-B1-C36;

A4-B1-C37; A4-B1-C38; A4-B1-C39; A4-B1-C40; A4-B1-C41; A4-B1-C42;

A4-B1-C43; A4-B1-C44; A4-B1-C45; A4-B1-C46; A5-BI-C1; A5-B1-C2;

A5-B1-C3; A5-B1-C4; A5-B1-C5; A5-B1-C6; A5-B1-C7; A5-B1-C8;

A5-B1-C9; A5-B1-C10; A5-B1-C11; A5-B1-C12; A5-B1-C13; A5-B1-C14;

A5-B1-C15; A5-B1-C16; A5-B1-C17; A5-B1-C18; A5-B1-C19; A5-B1-C20;

A5-B1-C21; A5-B1-C22; A5-B1-C23; A5-B1-C24; A5-B1-C25; A5-B1-C26;

A5-B1-C27; A5-B1-C28; A5-B1-C29; A5-B1-C30; A5-B1-C31; A5-B1-C32;

A5-B1-C33; A5-B1-C34; A5-B1-C35; A5-B1-C36; A5-B1-C37; A5-B1-C38;

A5-B1-C39; A5-B1-C40; A5-B1-C41; A5-B1-C42; A5-B1-C43; A5-B1-C44;

A5-B1-C45; A5-B1-C46; A6-B1-Cl; A6-Bl-C2; A6-Bl-C3; A6-Bl-C4;

A6-BI-C5; A6-B1-C6; A6-B1-C7; A6-B1-C8; A6-Bl-C9; A6-B1-C10;

A6-B1-C11; A6-B1-C12; A6-B1-C13; A6-B1-C14; A6-B1-C15; A6-B1-C16;

A6-B1-C17; A6-B1-C18; A6-B1-C19; A6-B1-C20; A6-B1-C21; A6-B1-C22;

A6-B1-C23; A6-B1-C24; A6-B1-C25; A6-B1-C26; A6-B1-C27; A6-B1-C28;

A6-B1-C29; A6-B1-C30; A6-B1-C31; A6-B1-C32; A6-B1-C33; A6-B1-C34;

A6-B1-C35; A6-B1-C36; A6-B1-C37; A6-B1-C38; A6-B1-C39; A6-B1-C40;

A6-B1-C41; A6-B1-C42; A6-B1-C43; A6-B1-C44; A6-B1-C45; A6-B1-C46;

A7-B1-Cl; A7-B1-C2; A7-B1-C3; A7-B1-C4; A7-B1-C5; A7-BI-C6;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -38A7-B1-C7; A7-B1-C8; A7-B1-C9; A7-B1-C10; A7-B1-C11; A7-B1-C12;

A7-B1-C13; A7-B1-C14; A7-B1-C15; A7-B1-C16; A7-B1-C17; A7-B1-C18;

A7-B1-C19; A7-B1-C20; A7-B1-C21; A7-B1-C22; A7-B1-C23; A7-B1-C24;

A7-B1-C25; A7-B1-C26; A7-B1-C27; A7-B1-C28; A7-B1-C29; A7-B1-C30;

A7-B1-C31; A7-B1-C32; A7-B1-C33; A7-B1-C34; A7-B1-C35; A7-B1-C36;

A7-B1-C37; A7-B1-C38; A7-B1-C39; A7-B1-C40; A7-B1-C41; A7-B1-C42;

A7-B1-C43; A7-B1-C44; A7-Bl-C45; A7-B1-C46; A8-B1-C1; A8-B1-C2;

A8-B1-C3; A8-B1-C4; A8-B1-C5; A8-B1-C6; A8-Bl-C7; A8-BI-C8;

A8-B1-C9; A8-B1-C10; A8-B1-C11; A8-B1-C12; A8-B1-C13; A8-B1-C14;

A8-B1-C15; A8-B1-C16; A8-B1-C17; A8-B1-C18; A8-B1-C19; A8-B1-C20;

A8-B1-C21; A8-B1-C22; A8-B1-C23; A8-B1-C24; A8-B1-C25; A8-B1-C26;

A8-B1-C27; A8-B1-C28; A8-B1-C29; A8-B1-C30; A8-B1-C31; A8-B1-C32;

A8-B1-C33; A8-B1-C34; A8-B1-C35; A8-B1-C36; A8-B1-C37; A8-Bl-C38;

A8-B1-C39; A8-B1-C40; A8-B1-C41; A8-B1-C42; A8-B1-C43; A8-B1-C44;

A8-B1-C45; A8-BI-C46; A9-B1-C1; A9-B1-C2; A9-BI-C3; A9-BI-C4;

A9-Bl-C5; A9-B1-C6; A9-B1-C7; A9-B1-C8; A9-B1-C9; A9-B1-C10;

A9-B1-C11; A9-B1-C12; A9-B1-C13; A9-B1-C14; A9-B1-C15; A9-B1-C16;

A9-B1-C17; A9-B1-C18; A9-B1-C19; A9-B1-C20; A9-B1-C21; A9-Bl-C22;

A9-B1-C23; A9-B1-C24; A9-B1-C25; A9-B1-C26; A9-B1-C27; A9-B1-C28;

A9-Bl-C29; A9-B1-C30; A9-B1-C31; A9-Bl-C32; A9-B1-C33; A9-B1-C34;

A9-B1-C35; A9-B1-C36; A9-B1-C37; A9-B1-C38; A9-B1-C39; A9-B1-C40;

A9-B1-C41; A9-B1-C42; A9-B1-C43; A9-B1-C44; A9-B1-C45; A9-B1-C46;

A10-B1-Ci; A10-B1-C2; A10-B1-C3; A10-B1-C4; A10-B1-C5; A10-B1-C6;

A10-B1-C7; A10-B1-C8; A10-B1-C9; A10-B1-C10; A10-B1-C11; A10-B1-C12;

A10-B1-C13; A10-Bl-C14; A10-B1-C15; A10-B1-C16; A10-B1-C17; A10-B1-C18;

A10-B1-C19; A10-B1-C20; A10-B1-C21; A10-B1-C22; A10-B1-C23; A10-B1-C24;

Al0-B1-C25; A10-B1-C26; A10-B1-C27; A10-B1-C28; A10-B1-C29; A10-B1-C30;

A10-B1-C31; A10-B1-C32; A10-B1-C33; A10-B1-C34; A10-B1-C35; A10-B1-C36;

A10-B1-C37; A10-B1-C38; A10-B1-C39; A10-B1-C40; A10-Bl-C41; A10-B1-C42;

A10-B1-C43; A10-B1-C44; A10-B1-C45; A10-B1-C46; All-B1-Cl; All-B1-C2;

All-Bl-C3; All-Bl-C4; All-B1-C5; All-B1-C6; All-B1-C7; All-BI-C8;

All-Bl-C9; All-B1-C10; All-Bl-Cll; All-Bl-C12; Al1-Bl-C13; All-BI-C14;

All-Bl-C15; All-B1-C16; All-BI-C17; All-B1-C18; All-B1-C19; All-BI-C20;

All-B1-C21; All-B1-C22; All-B1-C23; All-B1-C24; All-B1-C25; All-BI-C26;

All-B1-C27; All-B1-C28; All-Bl-C29; All-B1-C30; All-B1-C31; All-B1-C32;

All-B1-C33; All-B1-C34; All-B1-C35; All-B1-C36; All-B1-C37; All-B1-C38;

All-BI-C39; All-B1-C40; All-Bl-C41; All-Bl-C42; All-BI-C43; All-Bl-C44;

All-Bl-C45; All-B1-C46; A12-Bl-Cl; A12-B1-C2; A12-B1-C3; A12-B1-C4;

A12-B1-C5; A12-B1-C6; A12-B1-C7; A12-B1-C8; A12-B1-C9; A12-B1-C10;

A12-B1-C11; A12-B1-C12; A12-B1-C13; A12-B1-C14; A12-B1-C15; A12-B1-C16;

A12-B1-C17; A12-B1-C18; A12-B1-C19; A12-Bl-C20; A12-B1-C21; A12-B1-C22;

A12-B1-C23; A12-B1-C24; A12-B1-C25; A12-B1-C26; A12-B1-C27; A12-Bl-C28;

A12-B1-C29; A12-B1-C30; A12-B1-C31; A12-B1-C32; A12-B1-C33; A12-B1-C34;

A12-Bl-C35; A12-B1-C36; A12-B1-C37; A12-B1-C38; A12-Bl-C39; A12-B1-C40;

A12-B1-C41; A12-B1-C42; A12-B1-C43; A12-B1-C44; A12-B1-C45; A12-B1-C46;

A13-B1-Cl; A13-B1-C2; A13-B1-C3; A13-B1-C4; A13-B1-C5; A13-B1-C6;

A13-B1-C7; A13-Bl-C8; A13-B1-C9; A13-B1-C10; A13-Bl-Cll; A13-B1-C12;

A13-Bl-C13; A13-Bl-C14; A13-B1-C15; A13-Bl-C16; A13-B1-C17; A13-B1-C18;

A13-Bl-Cl9; A13-B1-C20; A13-Bl-C21; A13-Bl-C22; A13-B1-C23; A13-Bl-C24;

A13-B1-C25; A13-B1-C26; A13-B1-C27; A13-B1-C28; A13-B1-C29; A13-Bl-C30;

A13-B1-C31; A13-B1-C32; A13-B1-C33; A13-B1-C34; A13-B1-C35; A13-B1-C36;

A13-B1-C37; A13-B1-C38; A13-B1-C39; A13-B1-C40; A13-Bl-C41; A13-B1-C42;

A13-B1-C43; A13-B1-C44; A13-B1-C45; A13-B1-C46; A14-B1-Cl; A14-B1-C2;

A14-B1-C3; A14-B1-C4; A14-B1-C5; A14-B1-C6; A14-B1-C7; A14-B1-C8;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -39A14-B1-C9; A14-B1-C10; A14-B1-Cll; A14-B1-C12; A14-B1-C13; A14-B1-C14;

A14-B1-C15; A14-B1-C16; A14-B1-C17; A14-B1-C18; A14-B1-C19; A14-B1-C20;

A14-B1-C21; A14-B1-C22; A14-B1-C23; A14-B1-C24; A14-B1-C25; A14-B1-C26;

A14-B1-C27; A14-B1-C28; A14-B1-C29; A14-B1-C30; A14-B1-C31; A14-B1-C32;

A14-B1-C33; A14-B1-C34; A14-B1-C35; A14-B1-C36; A14-B1-C37; A14-B1-C38;

A14-B1-C39; A14-B1-C40; A14-B1-C41; A14-B1-C42; A14-B1-C43; A14-B1-C44;

A14-B1-C45; A14-B1-C46; A15-B1-C1; A15-B1-C2; A15-B1-C3; A15-B1-C4;

A15-B1-C5; A15-B1-C6; A15-B1-C7; A15-B1-C8; A15-B1-C9; A15-B1-C10;

A15-B1-C11; A15-B1-C12; A15-B1-C13; A15-B1-C14; A15-B1-C15; A15-B1-C16;

A15-B1-C17; A15-B1-C18; A15-B1-C19; A15-B1-C20; A15-B1-C21; A15-B1-C22;

A15-B1-C23; A15-B1-C24; A15-B1-C25; A15-B1-C26; A15-B1-C27; A15-B1-C28;

A15-B1-C29; A15-B1-C30; A15-B1-C31; A15-B1-C32; A15-B1-C33; A15-B1-C34;

A15-B1-C35; A15-B1-C36; A15-B1-C37; A15-B1-C38; A15-B1-C39; A15-B1-C40;

A15-B1-C41; A15-B1-C42; A15-B1-C43; A15-B1-C44; A15-B1-C45; A15-B1-C46;

A16-B1-C1; A16-B1-C2; A16-B1-C3; A16-B1-C4; A16-B1-C5; A16-B1-C6;

A16-B1-C7; A16-B1-C8; A16-B1-C9; A16-B1-C10; A16-B1-C11; A16-B1-C12;

A16-B1-C13; A16-B1-C14; A16-B1-C15; A16-B1-C16; A16-B1-C17; A16-B1-C18;

A16-B1-C19; A16-B1-C20; A16-B1-C21; A16-B1-C22; A16-B1-C23; A16-B1-C24;

A16-B1-C25; A16-B1-C26; A16-B1-C27; A16-B1-C28; A16-B1-C29; A16-B1-C30;

A16-B1-C31; A16-B1-C32; A16-B1-C33; A16-B1-C34; A16-B1-C35; A16-B1-C36;

A16-B1-C37; A16-B1-C38; A16-B1-C39; A16-B1-C40; A16-B1-C41; A16-B1-C42;

A16-B1-C43; A16-B1-C44; A16-B1-C45; A16-B1-C46; A17-B1-C1; A17-B1-C2;

A17-B1-C3; A17-B1-C4; A17-B1-C5; A17-B1-C6; A17-B1-C7; A17-B1-C8;

A17-B1-C9; A17-B1-C10; A17-B1-C11; A17-B1-C12; A17-B1-C13; A17-B1-C14;

A17-B1-C15; A17-B1-C16; A17-B1-C17; A17-B1-C18; A17-B1-C19; A17-B1-C20;

A17-B1-C21; A17-B1-C22; A17-B1-C23; A17-B1-C24; A17-B1-C25; A17-B1-C26;

A17-B1-C27; A17-B1-C28; A17-B1-C29; A17-B1-C30; A17-B1-C31; A17-B1-C32;

A17-B1-C33; A17-B1-C34; A17-B1-C35; A17-B1-C36; A17-B1-C37; A17-B1-C38;

A17-B1-C39; A17-B1-C40; A17-B1-C41; A17-B1-C42; A17-B1-C43; A17-B1-C44;

A17-B1-C45; A17-B1-C46; A18-B1-C1; A18-B1-C2; A18-B1-C3; A18-B1-C4;

A18-B1-C5; A18-B1-C6; A18-B1-C7; A18-B1-C8; A18-B1-C9; A18-B1-C10;

A18-B1-C11; A18-B1-C12; A18-B1-C13; A18-B1-C14; A18-B1-C15; A18-B1-C16;

A18-B1-C17; A18-B1-C18; A18-B1-C19; A18-B1-C20; A18-B1-C21; A18-B1-C22;

A18-B1-C23; A18-B1-C24; A18-B1-C25; A18-B1-C26; A18-B1-C27; A18-B1-C28;

A18-B1-C29; A18-B1-C30; A18-B1-C31; A18-B1-C32; A18-B1-C33; A18-B1-C34;

A18-B1-C35; A18-B1-C36; A18-B1-C37; A18-B1-C38; A18-B1-C39; A18-B1-C40;

A18-B1-C41; A18-B1-C42; A18-B1-C43; A18-B1-C44; A18-B1-C45; A18-B1-C46;

A19-B1-C1; A19-B1-C2; A19-B1-C3; A19-B1-C4; A19-B1-C5; A19-B1-C6;

A19-B1-C7; A19-B1-C8; A19-B1-C9; A19-B1-C10; A19-B1-Cll; A19-B1-C12;

A19-B1-C13; A19-B1-C14; A19-B1-C15; A19-B1-C16; A19-B1-C17; A19-B1-C18;

A19-B1-C19; A19-B1-C20; A19-B1-C21; A19-B1-C22; A19-B1-C23; A19-B1-C24;

A19-B1-C25; A19-B1-C26; A19-B1-C27; A19-B1-C28; A19-B1-C29; A19-B1-C30;

A19-B1-C31; A19-B1-C32; A19-B1-C33; A19-B1-C34; A19-B1-C35; A19-B1-C36;

A19-B1-C37; A19-B1-C38; A19-B1-C39; A19-B1-C40; A19-B1-C41; A19-B1-C42;

A19-B1-C43; A19-B1-C44; A19-B1-C45; A19-B1-C46; A20-B1-Cl; A20-B1-C2;

A20-B1-C3; A20-B1-C4; A20-B1-C5; A20-B1-C6; A20-B1-C7; A20-B1-C8;

A20-B1-C9; A20-B1-C10; A20-B1-C11; A20-B1-C12; A20-B1-C13; A20-B1-C14;

A20-B1-C15; A20-B1-C16; A20-B1-C17; A20-B1-C18; A20-B1-C19; A20-B1-C20;

A20-B1-C21; A20-B1-C22; A20-B1-C23; A20-B1-C24; A20-B1-C25; A20-B1-C26;

A20-B1-C27; A20-B1-C28; A20-B1-C29; A20-B1-C30; A20-B1-C31; A20-B1-C32;

A20-B1-C33; A20-B1-C34; A20-B1-C35; A20-B1-C36; A20-B1-C37; A20-B1-C38;

A20-B1-C39; A20-B1-C40; A20-B1-C41; A20-B1-C42; A20-B1-C43; A20-B1-C44;

A20-B1-C45; A20-B1-C46; A21-B1-C1; A21-B1-C2; A21-B1-C3; A21-B1-C4;

A21-B1-C5; A21-B1-C6; A21-B1-C7; A21-B1-C8; A21-B1-C9; A21-B1-C10;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -40A21-Bl-C11; A21-B1-C12; A21-B1-C13; A21-B1-C14; A21-BI-C15; A21-B1-C16;

A21-B1-C17; A21-B1-C18; A21-B1-C19; A21-B1-C20; A21-B1-C21; A21-B1-C22;

A21-B1-C23; A21-B1-C24; A21-B1-C25; A21-B1-C26; A21-B1-C27; A21-B1-C28;

A21-B1-C29; A21-B1-C30; A21-B1-C31; A21-B1-C32; A21-B1-C33; A21-B1-C34;

A21-B1-C35; A21-B1-C36; A21-B1-C37; A21-B1-C38; A21-B1-C39; A21-B1-C40;

A21-B1-C41; A21-B1-C42; A21-B1-C43; A21-B1-C44; A21-B1-C45; A21-B1-C46;

A22-B1-C1; A22-B1-C2; A22-B1-C3; A22-B1-C4; A22-B1-C5; A22-B1-C6;

A22-B1-C7; A22-B1-C8; A22-B1-C9; A22-B1-C10; A22-B1-C11; A22-B1-C12;

A22-B1-C13; A22-B1-C14; A22-B1-C15; A22-B1-C16; A22-B1-C17; A22-B1-C18;

A22-B1-C19; A22-B1-C20; A22-B1-C21; A22-B1-C22; A22-B1-C23; A22-B1-C24;

A22-B1-C25; A22-B1-C26; A22-B1-C27; A22-B1-C28; A22-B1-C29; A22-B1-C30;

A22-B1-C31; A22-B1-C32; A22-B1-C33; A22-B1-C34; A22-B1-C35; A22-B1-C36;

A22-B1-C37; A22-B1-C38; A22-B1-C39; A22-B1-C40; A22-B1-C41; A22-B1-C42;

A22-B1-C43; A22-B1-C44; A22-B1-C45; A22-B1-C46; A23-B1-C1; A23-B1-C2;

A23-B1-C3; A23-B1-C4; A23-B1-C5; A23-B1-C6; A23-B1-C7; A23-B1-C8;

A23-B1-C9; A23-B1-C10; A23-B1-C11; A23-B1-C12; A23-B1-C13; A23-B1-C14;

A23-B1-C15; A23-B1-C16; A23-B1-C17; A23-B1-C18; A23-B1-C19; A23-B1-C20;

A23-B1-C21; A23-B1-C22; A23-B1-C23; A23-B1-C24; A23-B1-C25; A23-B1-C26;

A23-B1-C27; A23-B1-C28; A23-B1-C29; A23-B1-C30; A23-B1-C31; A23-B1-C32;

A23-B1-C33; A23-B1-C34; A23-B1-C35; A23-B1-C36; A23-B1-C37; A23-B1-C38;

A23-B1-C39; A23-B1-C40; A23-B1-C41; A23-B1-C42; A23-B1-C43; A23-B1-C44;

A23-B1-C45; A23-B1-C46; A24-B1-C1; A24-B1-C2; A24-B1-C3; A24-B1-C4;

A24-B1-C5; A24-B1-C6; A24-B1-C7; A24-B1-C8; A24-B1-C9; A24-B1-C10;

A24-B1-Cll; A24-BI-C12; A24-BI-C13; A24-B1-C14; A24-BI-C15; A24-B1-C16;

A24-B1-C17; A24-B1-C18; A24-B1-C19; A24-B1-C20; A24-B1-C21; A24-B1-C22;

A24-B1-C23; A24-B1-C24; A24-B1-C25; A24-B1-C26; A24-B1-C27; A24-B1-C28;

A24-B1-C29; A24-B1-C30; A24-B1-C31; A24-B1-C32; A24-B1-C33; A24-B1-C34;

A24-B1-C35; A24-B1-C36; A24-B1-C37; A24-B1-C38; A24-B1-C39; A24-B1-C40;

A24-B1-C41; A24-B1-C42; A24-B1-C43; A24-B1-C44; A24-B1-C45; A24-BI-C46;

A25-B1-C1; A25-B1-C2; A25-B1-C3; A25-B1-C4; A25-B1-C5; A25-B1-C6;

A25-B1-C7; A25-B1-C8; A25-B1-C9; A25-B1-C10; A25-B1-C11; A25-B1-C12;

A25-B1-C13; A25-B1-C14; A25-B1-C15; A25-B1-C16; A25-B1-C17; A25-B1-C18;

A25-B1-C19; A25-B1-C20; A25-B1-C21; A25-B1-C22; A25-B1-C23; A25-B1-C24;

A25-B1-C25; A25-B1-C26; A25-B1-C27; A25-B1-C28; A25-B1-C29; A25-B1-C30;

A25-B1-C31; A25-B1-C32; A25-B1-C33; A25-B1-C34; A25-B1-C35; A25-B1-C36;

A25-B1-C37; A25-B1-C38; A25-B1-C39; A25-B1-C40; A25-B1-C41; A25-B1-C42;

A25-B1-C43; A25-B1-C44; A25-B1-C45; A25-B1-C46; A26-BI-Cl; A26-B1-C2;

A26-B1-C3; A26-B1-C4; A26-B1-C5; A26-B1-C6; A26-B1-C7; A26-B1-C8;

A26-B1-C9; A26-B1-C10; A26-B1-C11; A26-B1-C12; A26-B1-C13; A26-B1-C14;

A26-B1-C15; A26-B1-C16; A26-B1-C17; A26-B1-C18; A26-B1-C19; A26-B1-C20;

A26-B1-C21; A26-B1-C22; A26-B1-C23; A26-B1-C24; A26-B1-C25; A26-B1-C26;

A26-B1-C27; A26-B1-C28; A26-B1-C29; A26-B1-C30; A26-B1-C31; A26-B1-C32;

A26-B1-C33; A26-B1-C34; A26-B1-C35; A26-B1-C36; A26-B1-C37; A26-B1-C38;

A26-B1-C39; A26-B1-C40; A26-B1-C41; A26-B1-C42; A26-B1-C43; A26-B1-C44;

A26-B1-C45; A26-B1-C46; A27-B1-C1; A27-B1-C2; A27-B1-C3; A27-B1-C4;

A27-B1-C5; A27-B1-C6; A27-B1-C7; A27-B1-C8; A27-B1-C9; A27-B1-C10;

A27-B1-Cll; A27-B1-C12; A27-B1-C13; A27-B1-C14; A27-B1-C15; A27-B1-C16;

A27-B1-C17; A27-B1-C18; A27-B1-C19; A27-B1-C20; A27-B1-C21; A27-B1-C22;

A27-B1-C23; A27-B1-C24; A27-B1-C25; A27-B1-C26; A27-B1-C27; A27-B1-C28;

A27-B1-C29; A27-B1-C30; A27-B1-C31; A27-B1-C32; A27-B1-C33; A27-B1-C34;

A27-B1-C35; A27-B1-C36; A27-B1-C37; A27-B1-C38; A27-B1-C39; A27-B1-C40;

A27-B1-C41; A27-B1-C42; A27-B1-C43; A27-B1-C44; A27-B1-C45; A27-B1-C46;

A28-B1-C1; A28-B1-C2; A28-B1-C3; A28-B1-C4; A28-B1-C5; A28-B1-C6;

A28-B1-C7; A28-B1-C8; A28-B1-C9; A28-B1-C10; A28-B1-C11; A28-B1-C12;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -41A28-B1-C13; A28-B1-C14; A28-B1-C15; A28-B1-C16; A28-B1-C17; A28-B1-C18;

A28-BI-C19; A28-BI-C20; A28-B1-C21; A28-B1-C22; A28-B1-C23; A28-B1-C24;

A28-B1-C25; A28-B1-C26; A28-B1-C27; A28-B1-C28; A28-B1-C29; A28-B1-C30;

A28-B1-C31; A28-B1-C32; A28-B1-C33; A28-B1-C34; A28-B1-C35; A28-B1-C36;

A28-B1-C37; A28-B1-C38; A28-B1-C39; A28-B1-C40; A28-B1-C41; A28-B1-C42;

A28-B1-C43; A28-B1-C44; A28-B1-C45; A28-B1-C46; Al-B2-Cl; Al-B2-C2;

Al-B2-C3; Al-B2-C4; Al-B2-C5; Al-B2-C6; Al-B2-C7; Al-B2-C8;

Al-B2-C9; Al-B2-C10; Al-B2-C11; Al-B2-C12; Al-B2-C13; Al-B2-C14;

Al-B2-C15; Al-B2-C16; Al-B2-C17; Al-B2-C18; Al-B2-C19; Al-B2-C20;

Al-B2-C21; Al-B2-C22; Al-B2-C23; Al-B2-C24; Al-B2-C25; Al-B2-C26;

Al-B2-C27; Al-B2-C28; Al-B2-C29; Al-B2-C30; Al-B2-C31; Al-B2-C32;

Al-B2-C33; Al-B2-C34; Al-B2-C35; Al-B2-C36; Al-B2-C37; Al-B2-C38;

Al-B2-C39; Al-B2-C40; Al-B2-C41; Al-B2-C42; Al-B2-C43; Al-B2-C44;

Al-B2-C45; Al-B2-C46; A2-B2-C1; A2-B2-C2; A2-B2-C3; A2-B2-C4;

A2-B2-C5; A2-B2-C6; A2-B2-C7; A2-B2-C8; A2-B2-C9; A2-B2-C10;

A2-B2-C11; A2-B2-C12; A2-B2-C13; A2-B2-C14; A2-B2-C15; A2-B2-C16;

A2-B2-C17; A2-B2-C18; A2-B2-C19; A2-B2-C20; A2-B2-C21; A2-B2-C22;

A2-B2-C23; A2-B2-C24; A2-B2-C25; A2-B2-C26; A2-B2-C27; A2-B2-C28;

A2-B2-C29; A2-B2-C30; A2-B2-C31; A2-B2-C32; A2-B2-C33; A2-B2-C34;

A2-B2-C35; A2-B2-C36; A2-B2-C37; A2-B2-C38; A2-B2-C39; A2-B2-C40;

A2-B2-C41; A2-B2-C42; A2-B2-C43; A2-B2-C44; A2-B2-C45; A2-B2-C46;

A3-B2-C1; A3-B2-C2; A3-B2-C3; A3-B2-C4; A3-B2-C5; A3-B2-C6;

A3-B2-C7; A3-B2-C8; A3-B2-C9; A3-B2-C10; A3-B2-Cll; A3-B2-C12;

A3-B2-C13; A3-B2-C14; A3-B2-C15; A3-B2-C16; A3-B2-C17; A3-B2-C18;

A3-B2-C19; A3-B2-C20; A3-B2-C21; A3-B2-C22; A3-B2-C23; A3-B2-C24;

A3-B2-C25; A3-B2-C26; A3-B2-C27; A3-B2-C28; A3-B2-C29; A3-B2-C30;

A3-B2-C31; A3-B2-C32; A3-B2-C33; A3-B2-C34; A3-B2-C35; A3-B2-C36;

A3-B2-C37; A3-B2-C38; A3-B2-C39; A3-B2-C40; A3-B2-C41; A3-B2-C42;

A3-B2-C43; A3-B2-C44; A3-B2-C45; A3-B2-C46; A4-B2-Cl; A4-B2-C2;

A4-B2-C3; A4-B2-C4; A4-B2-C5; A4-B2-C6; A4-B2-C7; A4-B2-C8;

A4-B2-C9; A4-B2-C10; A4-B2-C11; A4-B2-C12; A4-B2-C13; A4-B2-C14;

A4-B2-C15; A4-B2-C16; A4-B2-C17; A4-B2-C18; A4-B2-C19; A4-B2-C20;

A4-B2-C21; A4-B2-C22; A4-B2-C23; A4-B2-C24; A4-B2-C25; A4-B2-C26;

A4-B2-C27; A4-B2-C28; A4-B2-C29; A4-B2-C30; A4-B2-C31; A4-B2-C32;

A4-B2-C33; A4-B2-C34; A4-B2-C35; A4-B2-C36; A4-B2-C37; A4-B2-C38;

A4-B2-C39; A4-B2-C40; A4-B2-C41; A4-B2-C42; A4-B2-C43; A4-B2-C44;

A4-B2-C45; A4-B2-C46; A5-B2-Cl; A5-B2-C2; A5-B2-C3; A5-B2-C4;

A5-B2-C5; A5-B2-C6; A5-B2-C7; A5-B2-C8; A5-B2-C9; A5-B2-C10;

A5-B2-Cll; A5-B2-C12; A5-B2-C13; A5-B2-C14; A5-B2-C15; A5-B2-C16;

A5-B2-C17; A5-B2-C18; A5-B2-C19; A5-B2-C20; A5-B2-C21; A5-B2-C22;

A5-B2-C23; A5-B2-C24; A5-B2-C25; A5-B2-C26; A5-B2-C27; A5-B2-C28;

A5-B2-C29; A5-B2-C30; A5-B2-C31; A5-B2-C32; A5-B2-C33; A5-B2-C34;

A5-B2-C35; A5-B2-C36; A5-B2-C37; A5-B2-C38; A5-B2-C39; A5-B2-C40;

A5-B2-C41; A5-B2-C42; A5-B2-C43; A5-B2-C44; A5-B2-C45; A5-B2-C46;

A6-B2-C1; A6-B2-C2; A6-B2-C3; A6-B2-C4; A6-B2-C5; A6-B2-C6;

A6-B2-C7; A6-B2-C8; A6-B2-C9; A6-B2-C10; A6-B2-C11; A6-B2-C12;

A6-B2-C13; A6-B2-C14; A6-B2-C15; A6-B2-C16; A6-B2-C17; A6-B2-C18;

A6-B2-C19; A6-B2-C20; A6-B2-C21; A6-B2-C22; A6-B2-C23; A6-B2-C24;

A6-B2-C25; A6-B2-C26; A6-B2-C27; A6-B2-C28; A6-B2-C29; A6-B2-C30;

A6-B2-C31; A6-B2-C32; A6-B2-C33; A6-B2-C34; A6-B2-C35; A6-B2-C36;

A6-B2-C37; A6-B2-C38; A6-B2-C39; A6-B2-C40; A6-B2-C41; A6-B2-C42;

A6-B2-C43; A6-B2-C44; A6-B2-C45; A6-B2-C46; A7-B2-C1; A7-B2-C2;

A7-B2-C3; A7-B2-C4; A7-B2-C5; A7-B2-C6; A7-B2-C7; A7-B2-C8;

A7-B2-C9; A7-B2-CIO; A7-B2-C11; A7-B2-C12; A7-B2-C13; A7-B2-C14;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -42A7-B2-C15; A7-B2-C16; A7-B2-C17; A7-B2-C18; A7-B2-C19; A7-B2-C20;

A7-B2-C21; A7-B2-C22; A7-B2-C23; A7-B2-C24; A7-B2-C25; A7-B2-C26;

A7-B2-C27; A7-B2-C28; A7-B2-C29; A7-B2-C30; A7-B2-C31; A7-B2-C32;

A7-B2-C33; A7-B2-C34; A7-B2-C35; A7-B2-C36; A7-B2-C37; A7-B2-C38;

A7-B2-C39; A7-B2-C40; A7-B2-C41; A7-B2-C42; A7-B2-C43; A7-B2-C44;

A7-B2-C45; A7-B2-C46; A8-B2-Cl; A8-B2-C2; A8-B2-C3; A8-B2-C4;

A8-B2-C5; A8-B2-C6; A8-B2-C7; A8-B2-C8; A8-B2-C9; A8-B2-C10;

A8-B2-C11; A8-B2-C12; A8-B2-C13; A8-B2-C14; A8-B2-C15; A8-B2-C16;

A8-B2-C17; A8-B2-C18; A8-B2-C19; A8-B2-C20; A8-B2-C21; A8-B2-C22;

A8-B2-C23; A8-B2-C24; A8-B2-C25; A8-B2-C26; A8-B2-C27; A8-B2-C28;

A8-B2-C29; A8-B2-C30; A8-B2-C31; A8-B2-C32; A8-B2-C33; A8-B2-C34;

A8-B2-C35; A8-B2-C36; A8-B2-C37; A8-B2-C38; A8-B2-C39; A8-B2-C40;

A8-B2-C41; A8-B2-C42; A8-B2-C43; A8-B2-C44; A8-B2-C45; A8-B2-C46;

A9-B2-C1; A9-B2-C2; A9-B2-C3; A9-B2-C4; A9-B2-C5; A9-B2-C6;

A9-B2-C7; A9-B2-C8; A9-B2-C9; A9-B2-C10; A9-B2-C11; A9-B2-C12;

A9-B2-C13; A9-B2-C14; A9-B2-C15; A9-B2-C16; A9-B2-C17; A9-B2-C18;

A9-B2-C19; A9-B2-C20; A9-B2-C21; A9-B2-C22; A9-B2-C23; A9-B2-C24;

A9-B2-C25; A9-B2-C26; A9-B2-C27; A9-B2-C28; A9-B2-C29; A9-B2-C30;

A9-B2-C31; A9-B2-C32; A9-B2-C33; A9-B2-C34; A9-B2-C35; A9-B2-C36;

A9-B2-C37; A9-B2-C38; A9-B2-C39; A9-B2-C40; A9-B2-C41; A9-B2-C42;

A9-B2-C43; A9-B2-C44; A9-B2-C45; A9-B2-C46; A10-B2-C1; A10-B2-C2;

A10-B2-C3; A10-B2-C4; A10-B2-C5; A10-B2-C6; A10-B2-C7; A10-B2-C8;

A10-B2-C9; A10-B2-C10; A10-B2-C11; A10-B2-C12; A10-B2-C13; A10-B2-C14;

A10-B2-Cl5; A10-B2-Cl6; A10-B2-C17; A10-B2-C18; A10-B2-C19; A10-B2-C20;

A10-B2-C21; A10-B2-C22; A10-B2-C23; A10-B2-C24; A10-B2-C25; A10-B2-C26;

A10-B2-C27; A10-B2-C28; A10-B2-C29; A10-B2-C30; A10-B2-C31; A10-B2-C32;

A10-B2-C33; A10-B2-C34; A10-B2-C35; A10-B2-C36; A10-B2-C37; A10-B2-C38;

A10-B2-C39; A10-B2-C40; A10-B2-C41; A10-B2-C42; A10-B2-C43; A10-B2-C44;

A10-B2-C45; A10-B2-C46; All-B2-Cl; All-B2-C2; All-B2-C3; All-B2-C4;

All-B2-C5; All-B2-C6; All-B2-C7; All-B2-C8; All-B2-C9; All-B2-ClO;

All-B2-Cll; All-B2-C12; All-B2-C13; All-B2-C14; All-B2-C15; All-B2-C16;

All-B2-C17; All-B2-C18; All-B2-C19; All-B2-C20; All-B2-C21.; All-B2-C22;

All-B2-C23; All-B2-C24; All-B2-C25; All-B2-C26; All-B2-C27; All-B2-C28;

All-B2-C29; All-B2-C30; All-B2-C31; All-B2-C32; All-B2-C33; All-B2-C34;

All-B2-C35; All-B2-C36; All-B2-C37; All-B2-C38; All-B2-C39; All-B2-C40;

All-B2-C41; All-B2-C42; All-B2-C43; All-B2-C44; All-B2-C45; All-B2-C46;

A12-B2-Cl; A12-B2-C2; A12-B2-C3; A12-B2-C4; A12-B2-C5; A12-B2-C6;

A12-B2-C7; A12-B2-C8; A12-B2-C9; A12-B2-C10; A12-B2-Cll; A12-B2-C12;

A12-B2-C13; A12-B2-C14; A12-B2-C15; A12-B2-C16; A12-B2-C17; A12-B2-C18;

A12-B2-C19; A12-B2-C20; A12-B2-C21; A12-B2-C22; A12-B2-C23; A12-B2-C24;

A12-B2-C25; A12-B2-C26; A12-B2-C27; A12-B2-C28; A12-B2-C29; A12-B2-C30;

A12-B2-C31; A12-B2-C32; A12-B2-C33; A12-B2-C34; A12-B2-C35; A12-B2-C36;

A12-B2-C37; A12-B2-C38; A12-B2-C39; A12-B2-C40; A12-B2-C41; A12-B2-C42;

A12-B2-C43; A12-B2-C44; A12-B2-C45; A12-B2-C46; A13-B2-C1; A13-B2-C2;

A13-B2-C3; A13-B2-C4; A13-B2-C5; A13-B2-C6; A13-B2-C7; A13-B2-C8;

A13-B2-C9; A13-B2-C10; A13-B2-C11; A13-B2-C12; A13-B2-C13; A13-B2-C14;

A13-B2-C15; A13-B2-C16; A13-B2-C17; A13-B2-C18; A13-B2-C19; A13-B2-C20;

A13-B2-C21; A13-B2-C22; A13-B2-C23; A13-B2-C24; A13-B2-C25; A13-B2-C26;

A13-B2-C27; A13-B2-C28; A13-B2-C29; A13-B2-C30; A13-B2-C31; A13-B2-C32;

A13-B2-C33; A13-B2-C34; A13-B2-C35; A13-B2-C36; A13-B2-C37; A13-B2-C38;

A13-B2-C39; A13-B2-C40; A13-B2-C41; A13-B2-C42; A13-B2-C43; A13-B2-C44;

A13-B2-C45; A13-B2-C46; A14-B2-C1; A14-B2-C2; A14-B2-C3; A14-B2-C4;

A14-B2-C5; A14-B2-C6; A14-B2-C7; A14-B2-C8; A14-B2-C9; A14-B2-C10;

A14-B2-C11; A14-B2-C12; A14-B2-C13; A14-B2-C14; A14-B2-C15; A14-B2-C16;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -43A14-B2-C17; A14-B2-C18; A14-B2-C19; A14-B2-C20; A14-B2-C21; A14-B2-C22;

A14-B2-C23; A14-B2-C24; A14-B2-C25; A14-B2-C26; A14-B2-C27; A14-B2-C28;

A14-B2-C29; A14-B2-C30; A14-B2-C31; A14-B2-C32; A14-B2-C33; A14-B2-C34;

A14-B2-C35; A14-B2-C36; A14-B2-C37; A14-B2-C38; A14-B2-C39; A14-B2-C40;

A14-B2-C41; A14-B2-C42; A14-B2-C43; A14-B2-C44; A14-B2-C45; A14-B2-C46;

A15-B2-Cl; A15-B2-C2; A15-B2-C3; A15-B2-C4; A15-B2-C5; A15-B2-C6;

A15-B2-C7; A15-B2-C8; A15-B2-C9; A15-B2-C10; A15-B2-C11; A15-B2-C12;

A15-B2-C13; A15-B2-C14; A15-B2-C15; A15-B2-C16; A15-B2-C17; A15-B2-C18;

A15-B2-C19; A15-B2-C20; A15-B2-C21; A15-B2-C22; A15-B2-C23; A15-B2-C24;

A15-B2-C25; A15-B2-C26; A15-B2-C27; A15-B2-C28; A15-B2-C29; A15-B2-C30;

A15-B2-C31; A15-B2-C32; A15-B2-C33; A15-B2-C34; A15-B2-C35; A15-B2-C36;

A15-B2-C37; A15-B2-C38; A15-B2-C39; A15-B2-C40; A15-B2-C41; A15-B2-C42;

A15-B2-C43; A15-B2-C44; A15-B2-C45; A15-B2-C46; A16-B2-C1; A16-B2-C2;

A16-B2-C3; A16-B2-C4; A16-B2-C5; A16-B2-C6; A16-B2-C7; A16-B2-C8;

A16-B2-C9; A16-B2-C10; A16-B2-C11; A16-B2-C12; A16-B2-C13; A16-B2-C14;

A16-B2-C15; A16-B2-C16; A16-B2-C17; A16-B2-C18; A16-B2-C19; A16-B2-C20;

A16-B2-C21; A16-B2-C22; A16-B2-C23; A16-B2-C24; A16-B2-C25; A16-B2-C26;

A16-B2-C27; A16-B2-C28; A16-B2-C29; A16-B2-C30; A16-B2-C31; A16-B2-C32;

A16-B2-C33; A16-B2-C34; A16-B2-C35; A16-B2-C36; A16-B2-C37; A16-B2-C38;

A16-B2-C39; A16-B2-C40; A16-B2-C41; A16-B2-C42; A16-B2-C43; A16-B2-C44;

A16-B2-C45; A16-B2-C46; A17-B2-C1; A17-B2-C2; A17-B2-C3; A17-B2-C4;

A17-B2-C5; A17-B2-C6; A17-B2-C7; A17-B2-C8; A17-B2-C9; A17-B2-C10;

A17-B2-C11; A17-B2-C12; A17-B2-C13; A17-B2-C14; A17-B2-C15; A17-B2-C16;

A17-B2-C17; A17-B2-C18; A17-B2-C19; A17-B2-C20; A17-B2-C21; A17-B2-C22;

A17-B2-C23; A17-B2-C24; A17-B2-C25; A17-B2-C26; A17-B2-C27; A17-B2-C28;

A17-B2-C29; A17-B2-C30; A17-B2-C31; A17-B2-C32; A17-B2-C33; A17-B2-C34;

A17-B2-C35; A17-B2-C36; A17-B2-C37; A17-B2-C38; A17-B2-C39; A17-B2-C40;

A17-B2-C41; A17-B2-C42; A17-B2-C43; A17-B2-C44; A17-B2-C45; A17-B2-C46;

A18-B2-C1; A18-B2-C2; A18-B2-C3; A18-B2-C4; A18-B2-C5; A18-B2-C6;

A18-B2-C7; A18-B2-C8; A18-B2-C9; A18-B2-C10; A18-B2-C11; A18-B2-C12;

A18-B2-C13; A18-B2-C14; A18-B2-C15; A18-B2-C16; A18-B2-C17; A18-B2-C18;

A18-B2-C19; A18-B2-C20; A18-B2-C21; A18-B2-C22; A18-B2-C23; A18-B2-C24;

A18-B2-C25; A18-B2-C26; A18-B2-C27; A18-B2-C28; A18-B2-C29; A18-B2-C30;

A18-B2-C31; A18-B2-C32; A18-B2-C33; A18-B2-C34; A18-B2-C35; A18-B2-C36;

A18-B2-C37; A18-B2-C38; A18-B2-C39; A18-B2-C40; A18-B2-C41; A18-B2-C42;

A18-B2-C43; A18-B2-C44; A18-B2-C45; A18-B2-C46; A19-B2-C1; A19-B2-C2;

A19-B2-C3; A19-B2-C4; A19-B2-C5; A19-B2-C6; A19-B2-C7; A19-B2-C8;

A19-B2-C9; A19-B2-C10; A19-B2-C11; A19-B2-C12; A19-B2-C13; A19-B2-C14;

A19-B2-C15; A19-B2-C16; A19-B2-C17; A19-B2-C18; A19-B2-C19; A19-B2-C20;

A19-B2-C21; A19-B2-C22; A19-B2-C23; A19-B2-C24; A19-B2-C25; A19-B2-C26;

A19-B2-C27; A19-B2-C28; A19-B2-C29; A19-B2-C30; A19-B2-C31; A19-B2-C32;

A19-B2-C33; A19-B2-C34; A19-B2-C35; A19-B2-C36; A19-B2-C37; A19-B2-C38;

A19-B2-C39; A19-B2-C40; A19-B2-C41; A19-B2-C42; A19-B2-C43; A19-B2-C44;

A19-B2-C45; A19-B2-C46; A20-B2-C1; A20-B2-C2; A20-B2-C3; A20-B2-C4;

A20-B2-C5; A20-B2-C6; A20-B2-C7; A20-B2-C8; A20-B2-C9; A20-B2-C10;

A20-B2-C11; A20-B2-C12; A20-B2-C13; A20-B2-C14; A20-B2-C15; A20-B2-C16;

A20-B2-C17; A20-B2-C18; A20-B2-C19; A20-B2-C20; A20-B2-C21; A20-B2-C22;

A20-B2-C23; A20-B2-C24; A20-B2-C25; A20-B2-C26; A20-B2-C27; A20-B2-C28;

A20-B2-C29; A20-B2-C30; A20-B2-C31; A20-B2-C32; A20-B2-C33; A20-B2-C34;

A20-B2-C35; A20-B2-C36; A20-B2-C37; A20-B2-C38; A20-B2-C39; A20-B2-C40;

A20-B2-C41; A20-B2-C42; A20-B2-C43; A20-B2-C44; A20-B2-C45; A20-B2-C46;

A21-B2-C1; A21-B2-C2; A21-B2-C3; A21-B2-C4; A21-B2-C5; A21-B2-C6;

A21-B2-C7; A21-B2-C8; A21-B2-C9; A21-B2-C10; A21-B2-C11; A21-B2-C12;

A21-B2-C13; A21-B2-C14; A21-B2-C15; A21-B2-C16; A21-B2-C17; A21-B2-C18;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -44A21-B2-C19; A21-B2-C20; A21-B2-C21; A21-B2-C22; A21-B2-C23; A21-B2-C24;

A21-B2-C25; A21-B2-C26; A21-B2-C27; A21-B2-C28; A21-B2-C29; A21-B2-C30;

A21-B2-C31; A21-B2-C32; A21-B2-C33; A21-B2-C34; A21-B2-C35; A21-B2-C36;

A21-B2-C37; A21-B2-C38; A21-B2-C39; A21-B2-C40; A21-B2-C41; A21-B2-C42;

A21-B2-C43; A21-B2-C44; A21-B2-C45; A21-B2-C46; A22-B2-Cl; A22-B2-C2;

A22-B2-C3; A22-B2-C4; A22-B2-C5; A22-B2-C6; A22-B2-C7; A22-B2-C8;

A22-B2-C9; A22-B2-C10; A22-B2-C11; A22-B2-C12; A22-B2-C13; A22-B2-C14;

A22-B2-C15; A22-B2-C16; A22-B2-C17; A22-B2-C18; A22-B2-C19; A22-B2-C20;

A22-B2-C21; A22-B2-C22; A22-B2-C23; A22-B2-C24; A22-B2-C25; A22-B2-C26;

A22-B2-C27; A22-B2-C28; A22-B2-C29; A22-B2-C30; A22-B2-C31; A22-B2-C32;

A22-B2-C33; A22-B2-C34; A22-B2-C35; A22-B2-C36; A22-B2-C37; A22-B2-C38;

A22-B2-C39; A22-B2-C40; A22-B2-C41; A22-B2-C42; A22-B2-C43; A22-B2-C44;

A22-B2-C45; A22-B2-C46; A23-B2-Cl; A23-B2-C2; A23-B2-C3; A23-B2-C4;

A23-B2-C5; A23-B2-C6; A23-B2-C7; A23-B2-C8; A23-B2-C9; A23-B2-C10;

A23-B2-C11; A23-B2-C12; A23-B2-C13; A23-B2-C14; A23-B2-C15; A23-B2-C16;

A23-B2-C17; A23-B2-C18; A23-B2-C19; A23-B2-C20; A23-B2-C21; A23-B2-C22;

A23-B2-C23; A23-B2-C24; A23-B2-C25; A23-B2-C26; A23-B2-C27; A23-B2-C28;

A23-B2-C29; A23-B2-C30; A23-B2-C31; A23-B2-C32; A23-B2-C33; A23-B2-C34;

A23-B2-C35; A23-B2-C36; A23-B2-C37; A23-B2-C38; A23-B2-C39; A23-B2-C40;

A23-B2-C41; A23-B2-C42; A23-B2-C43; A23-B2-C44; A23-B2-C45; A23-B2-C46;

A24-B2-C1; A24-B2-C2; A24-B2-C3; A24-B2-C4; A24-B2-C5; A24-B2-C6;

A24-B2-C7; A24-B2-C8; A24-B2-C9; A24-B2-C10; A24-B2-C11; A24-B2-C12;

A24-B2-C13; A24-B2-C14; A24-B2-C15; A24-B2-C16; A24-B2-C17; A24-B2-C18;

A24-B2-C19; A24-B2-C20; A24-B2-C21; A24-B2-C22; A24-B2-C23; A24-B2-C24;

A24-B2-C25; A24-B2-C26; A24-B2-C27; A24-B2-C28; A24-B2-C29; A24-B2-C30;

A24-B2-C31; A24-B2-C32; A24-B2-C33; A24-B2-C34; A24-B2-C35; A24-B2-C36;

A24-B2-C37; A24-B2-C38; A24-B2-C39; A24-B2-C40; A24-B2-C41; A24-B2-C42;

A24-B2-C43; A24-B2-C44; A24-B2-C45; A24-B2-C46; A25-B2-C1; A25-B2-C2;

A25-B2-C3; A25-B2-C4; A25-B2-C5; A25-B2-C6; A25-B2-C7; A25-B2-C8;

A25-B2-C9; A25-B2-C10; A25-B2-C11; A25-B2-C12; A25-B2-C13; A25-B2-C14;

A25-B2-C15; A25-B2-C16; A25-B2-C17; A25-B2-C18; A25-B2-C19; A25-B2-C20;

A25-B2-C21; A25-B2-C22; A25-B2-C23; A25-B2-C24; A25-B2-C25; A25-B2-C26;

A25-B2-C27; A25-B2-C28; A25-B2-C29; A25-B2-C30; A25-B2-C31; A25-B2-C32;

A25-B2-C33; A25-B2-C34; A25-B2-C35; A25-B2-C36; A25-B2-C37; A25-B2-C38;

A25-B2-C39; A25-B2-C40; A25-B2-C41; A25-B2-C42; A25-B2-C43; A25-B2-C44;

A25-B2-C45; A25-B2-C46; A26-B2-C1; A26-B2-C2; A26-B2-C3; A26-B2-C4;

A26-B2-C5; A26-B2-C6; A26-B2-C7; A26-B2-C8; A26-B2-C9; A26-B2-C10;

A26-B2-C11; A26-B2-C12; A26-B2-C13; A26-B2-C14; A26-B2-C15; A26-B2-C16;

A26-B2-C17; A26-B2-C18; A26-B2-C19; A26-B2-C20; A26-B2-C21; A26-B2-C22;

A26-B2-C23; A26-B2-C24; A26-B2-C25; A26-B2-C26; A26-B2-C27; A26-B2-C28;

A26-B2-C29; A26-B2-C30; A26-B2-C31; A26-B2-C32; A26-B2-C33; A26-B2-C34;

A26-B2-C35; A26-B2-C36; A26-B2-C37; A26-B2-C38; A26-B2-C39; A26-B2-C40;

A26-B2-C41; A26-B2-C42; A26-B2-C43; A26-B2-C44; A26-B2-C45; A26-B2-C46;

A27-B2-C1; A27-B2-C2; A27-B2-C3; A27-B2-C4; A27-B2-C5; A27-B2-C6;

A27-B2-C7; A27-B2-C8; A27-B2-C9; A27-B2-C10; A27-B2-C11; A27-B2-C12;

A27-B2-C13; A27-B2-C14; A27-B2-C15; A27-B2-C16; A27-B2-C17; A27-B2-C18;

A27-B2-C19; A27-B2-C20; A27-B2-C21; A27-B2-C22; A27-B2-C23; A27-B2-C24;

A27-B2-C25; A27-B2-C26; A27-B2-C27; A27-B2-C28; A27-B2-C29; A27-B2-C30;

A27-B2-C31; A27-B2-C32; A27-B2-C33; A27-B2-C34; A27-B2-C35; A27-B2-C36;

A27-B2-C37; A27-B2-C38; A27-B2-C39; A27-B2-C40; A27-B2-C41; A27-B2-C42;

A27-B2-C43; A27-B2-C44; A27-B2-C45; A27-B2-C46; A28-B2-Cl; A28-B2-C2;

A28-B2-C3; A28-B2-C4; A28-B2-C5; A28-B2-C6; A28-B2-C7; A28-B2-C8;

A28-B2-C9; A28-B2-C10; A28-B2-C11; A28-B2-C12; A28-B2-C13; A28-B2-C14;

A28-B2-C15; A28-B2-C16; A28-B2-C17; A28-B2-C18; A28-B2-C19; A28-B2-C20;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -45A28-B2-C21; A28-B2-C22; A28-B2-C23; A28-B2-C24; A28-B2-C25; A28-B2-C26;

A28-B2-C27; A28-B2-C28; A28-B2-C29; A28-B2-C30; A28-B2-C31; A28-B2-C32;

A28-B2-C33; A28-B2-C34; A28-B2-C35; A28-B2-C36; A28-B2-C37; A28-B2-C38;

A28-B2-C39; A28-B2-C40; A28-B2-C41; A28-B2-C42; A28-B2-C43; A28-B2-C44;

A28-B2-C45; A28-B2-C46; Al-B3-C1; Al-B3-C2; Al-B3-C3; Al-B3-C4;

Al-B3-C5; Al-B3-C6; Al-B3-C7; Al-B3-C8; Al-B3-C9; Al-B3-C10;

Al-B3-C11; Al-B3-C12; Al-B3-C13; Al-B3-C14; Al-B3-C15; Al-B3-C16;

Al-B3-C17; Al-B3-C18; Al-B3-C19; Al-B3-C20; Al-B3-C21; Al-B3-C22;

Al-B3-C23; Al-B3-C24; Al-B3-C25; Al-B3-C26; Al-B3-C27; Al-B3-C28;

Al-B3-C29; Al-B3-C30; Al-B3-C31; Al-B3-C32; Al-B3-C33; Al-B3-C34;

Al-B3-C35; Al-B3-C36; Al-B3-C37; Al-B3-C38; Al-B3-C39; Al-B3-C40;

Al-B3-C41; Al-B3-C42; Al-B3-C43; Al-B3-C44; Al-B3-C45; Al-B3-C46;

A2-B3-C1; A2-B3-C2; A2-B3-C3; A2-B3-C4; A2-B3-C5; A2-B3-C6;

A2-B3-C7; A2-B3-C8; A2-B3-C9; A2-B3-C10; A2-B3-C11; A2-B3-C12;

A2-B3-C13; A2-B3-C14; A2-B3-C15; A2-B3-C16; A2-B3-C17; A2-B3-C18;

A2-B3-C19; A2-B3-C20; A2-B3-C21; A2-B3-C22; A2-B3-C23; A2-B3-C24;

A2-B3-C25; A2-B3-C26; A2-B3-C27; A2-B3-C28; A2-B3-C29; A2-B3-C30;

A2-B3-C31; A2-B3-C32; A2-B3-C33; A2-B3-C34; A2-B3-C35; A2-B3-C36;

A2-B3-C37; A2-B3-C38; A2-B3-C39; A2-B3-C40; A2-B3-C41; A2-B3-C42;

A2-B3-C43; A2-B3-C44; A2-B3-C45; A2-B3-C46; A3-B3-C1; A3-B3-C2;

A3-B3-C3; A3-B3-C4; A3-B3-C5; A3-B3-C6; A3-B3-C7; A3-B3-C8;

A3-B3-C9; A3-B3-C10; A3-B3-C11; A3-B3-C12; A3-B3-C13; A3-B3-C14;

A3-B3-C15; A3-B3-C16; A3-B3-C17; A3-B3-C18; A3-B3-C19; A3-B3-C20;

A3-B3-C21; A3-B3-C22; A3-B3-C23; A3-B3-C24; A3-B3-C25; A3-B3-C26;

A3-B3-C27; A3-B3-C28; A3-B3-C29; A3-B3-C30; A3-B3-C31; A3-B3-C32;

A3-B3-C33; A3-B3-C34; A3-B3-C35; A3-B3-C36; A3-B3-C37; A3-B3-C38;

A3-B3-C39; A3-B3-C40; A3-B3-C41; A3-B3-C42; A3-B3-C43; A3-B3-C44;

A3-B3-C45; A3-B3-C46; A4-B3-C1; A4-B3-C2; A4-B3-C3; A4-B3-C4;

A4-B3-C5; A4-B3-C6; A4-B3-C7; A4-B3-C8; A4-B3-C9; A4-B3-C10;

A4-B3-C11; A4-B3-C12; A4-B3-C13; A4-B3-C14; A4-B3-C15; A4-B3-C16;

A4-B3-C17; A4-B3-C18; A4-B3-C19; A4-B3-C20; A4-B3-C21; A4-B3-C22;

A4-B3-C23; A4-B3-C24; A4-B3-C25; A4-B3-C26; A4-B3-C27; A4-B3-C28;

A4-B3-C29; A4-B3-C30; A4-B3-C31; A4-B3-C32; A4-B3-C33; A4-B3-C34;

A4-B3-C35; A4-B3-C36; A4-B3-C37; A4-B3-C38; A4-B3-C39; A4-B3-C40;

A4-B3-C41; A4-B3-C42; A4-B3-C43; A4-B3-C44; A4-B3-C45; A4-B3-C46;

A5-B3-C1; A5-B3-C2; A5-B3-C3; A5-B3-C4; A5-B3-C5; A5-B3-C6;

A5-B3-C7; A5-B3-C8; A5-B3-C9; A5-B3-C10; A5-B3-C11; A5-B3-C12;

A5-B3-C13; A5-B3-C14; A5-B3-C15; A5-B3-C16; A5-B3-C17; A5-B3-C18;

A5-B3-C19; A5-B3-C20; A5-B3-C21; A5-B3-C22; A5-B3-C23; A5-B3-C24;

A5-B3-C25; A5-B3-C26; A5-B3-C27; A5-B3-C28; A5-B3-C29; A5-B3-C30;

A5-B3-C31; A5-B3-C32; A5-B3-C33; A5-B3-C34; A5-B3-C35; A5-B3-C36;

A5-B3-C37; A5-B3-C38; A5-B3-C39; A5-B3-C40; A5-B3-C41; A5-B3-C42;

A5-B3-C43; A5-B3-C44; A5-B3-C45; A5-B3-C46; A6-B3-C1; A6-B3-C2;

A6-B3-C3; A6-B3-C4; A6-B3-C5; A6-B3-C6; A6-B3-C7; A6-B3-C8;

A6-B3-C9; A6-B3-C10; A6-B3-C11; A6-B3-C12; A6-B3-C13; A6-B3-C14;

A6-B3-C15; A6-B3-C16; A6-B3-C17; A6-B3-C18; A6-B3-C19; A6-B3-C20;

A6-B3-C21; A6-B3-C22; A6-B3-C23; A6-B3-C24; A6-B3-C25; A6-B3-C26;

A6-B3-C27; A6-B3-C28; A6-B3-C29; A6-B3-C30; A6-B3-C31; A6-B3-C32;

A6-B3-C33; A6-B3-C34; A6-B3-C35; A6-B3-C36; A6-B3-C37; A6-B3-C38;

A6-B3-C39; A6-B3-C40; A6-B3-C41; A6-B3-C42; A6-B3-C43; A6-B3-C44;

A6-B3-C45; A6-B3-C46; A7-B3-Cl; A7-B3-C2; A7-B3-C3; A7-B3-C4;

A7-B3-C5; A7-B3-C6; A7-B3-C7; A7-B3-C8; A7-B3-C9; A7-B3-C10;

A7-B3-C11; A7-B3-C12; A7-B3-C13; A7-B3-C14; A7-B3-C15; A7-B3-C16;

A7-B3-C17; A7-B3-C18; A7-B3-C19; A7-B3-C20; A7-B3-C21; A7-B3-C22;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -46A7-B3-C23; A7-B3-C24; A7-B3-C25; A7-B3-C26; A7-B3-C27; A7-B3-C28;

A7-B3-C29; A7-B3-C30; A7-B3-C31; A7-B3-C32; A7-B3-C33; A7-B3-C34;

A7-B3-C35; A7-B3-C36; A7-B3-C37; A7-B3-C38; A7-B3-C39; A7-B3-C40;

A7-B3-C41; A7-B3-C42; A7-B3-C43; A7-B3-C44; A7-B3-C45; A7-B3-C46;

A8-B3-C1; A8-B3-C2; A8-B3-C3; A8-B3-C4; A8-B3-C5; A8-B3-C6;

A8-B3-C7; A8-B3-C8; A8-B3-C9; A8-B3-ClO; A8-B3-Cll; A8-B3-C12;

A8-B3-C13; A8-B3-C14; A8-B3-C15; A8-B3-C16; A8-B3-C17; A8-B3-C18;

A8-B3-C19; A8-B3-C20; A8-B3-C21; A8-B3-C22; A8-B3-C23; A8-B3-C24;

A8-B3-C25; A8-B3-C26; A8-B3-C27; A8-B3-C28; A8-B3-C29; A8-B3-C30;

A8-B3-C31; A8-B3-C32; A8-B3-C33; A8-B3-C34; A8-B3-C35; A8-B3-C36;

A8-B3-C37; A8-B3-C38; A8-B3-C39; A8-B3-C40; A8-B3-C41; A8-B3-C42;

A8-B3-C43; A8-B3-C44; A8-B3-C45; A8-B3-C46; A9-B3-C1; A9-B3-C2;

A9-B3-C3; A9-B3-C4; A9-B3-C5; A9-B3-C6; A9-B3-C7; A9-B3-C8;

A9-B3-C9; A9-B3-C10; A9-B3-C11; A9-B3-C12; A9-B3-C13; A9-B3-C14;

A9-B3-C15; A9-B3-C16; A9-B3-C17; A9-B3-C18; A9-B3-C19; A9-B3-C20;

A9-B3-C21; A9-B3-C22; A9-B3-C23; A9-B3-C24; A9-B3-C25; A9-B3-C26;

A9-B3-C27; A9-B3-C28; A9-B3-C29; A9-B3-C30; A9-B3-C31; A9-B3-C32;

A9-B3-C33; A9-B3-C34; A9-B3-C35; A9-B3-C36; A9-B3-C37; A9-B3-C38;

A9-B3-C39; A9-B3-C40; A9-B3-C41; A9-B3-C42; A9-B3-C43; A9-B3-C44;

A9-B3-C45; A9-B3-C46; A10-B3-C1; A10-B3-C2; A10-B3-C3; A10-B3-C4;

A10-B3-C5; A10-B3-C6; A10-B3-C7; A10-B3-C8; A10-B3-C9; A10-B3-C10;

A10-B3-C11; A10-B3-C12; A10-B3-Cl3; A10-B3-C14; A10-B3-C15; A10-B3-C16;

A10-B3-C17; A10-B3-C18; A10-B3-C19; A10-B3-C20; A10-B3-C21; A10-B3-C22;

A10-B3-C23; A10-B3-C24; A10-B3-C25; A10-B3-C26; A10-B3-C27; A10-B3-C28;

A10-B3-C29; A10-B3-C30; A10-B3-C31; A10-B3-C32; A10-B3-C33; A10-B3-C34;

A10-B3-C35; A10-B3-C36; A10-B3-C37; A10-B3-C38; A10-B3-C39; A10-B3-C40;

A10-B3-C41; A10-B3-C42; A10-B3-C43; A10-B3-C44; A10-B3-C45; A10-B3-C46;

All-B3-Cl; All-B3-C2; All-B3-C3; All-B3-C4; All-B3-C5; All-B3-C6;

All-B3-C7; All-B3-C8; All-B3-C9; All-B3-C10; All-B3-Cll; All-B3-C12;

All-B3-C13; All-B3-C14; All-B3-C15; All-B3-C16; All-B3-C17; All-B3-C18;

All-B3-C19; All-B3-C20; All-B3-C21; All-B3-C22; All-B3-C23; All-B3-C24;

All-B3-C25; All-B3-C26; All-B3-C27; All-B3-C28; All-B3-C29; All-B3-C30;

All-B3-C31; All-B3-C32; All-B3-C33; All-B3-C34; All-B3-C35; All-B3-C36;

All-B3-C37; All-B3-C38; All-B3-C39; All-B3-C40; All-B3-C41; All-B3-C42;

All-B3-C43; All-B3-C44; All-B3-C45; All-B3-C46; A12-B3-C1; A12-B3-C2;

A12-B3-C3; A12-B3-C4; A12-B3-C5; A12-B3-C6; A12-B3-C7; A12-B3-C8;

A12-B3-C9; A12-B3-C10; A12-B3-C11; A12-B3-C12; A12-B3-C13; A12-B3-C14;

A12-B3-C15; A12-B3-C16; A12-B3-C17; A12-B3-C18; A12-B3-C19; A12-B3-C20;

A12-B3-C21; A12-B3-C22; A12-B3-C23; A12-B3-C24; A12-B3-C25; A12-B3-C26;

A12-B3-C27; A12-B3-C28; A12-B3-C29; A12-B3-C30; A12-B3-C31; A12-B3-C32;

A12-B3-C33; A12-B3-C34; A12-B3-C35; A12-B3-C36; A12-B3-C37; A12-B3-C38;

A12-B3-C39; A12-B3-C40; A12-B3-C41; A12-B3-C42; A12-B3-C43; A12-B3-C44;

A12-B3-C45; A12-B3-C46; A13-B3-C1; A13-B3-C2; A13-B3-C3; A13-B3-C4;

A13-B3-C5; A13-B3-C6; A13-B3-C7; A13-B3-C8; A13-B3-C9; A13-B3-C10;

A13-B3-C11; A13-B3-C12; A13-B3-C13; A13-B3-C14; A13-B3-C15; A13-B3-C16;

A13-B3-C17; A13-B3-C18; A13-B3-C19; A13-B3-C20; A13-B3-C21; A13-B3-C22;

A13-B3-C23; A13-B3-C24; A13-B3-C25; A13-B3-C26; A13-B3-C27; A13-B3-C28;

A13-B3-C29; A13-B3-C30; A13-B3-C31; A13-B3-C32; A13-B3-C33; A13-B3-C34;

A13-B3-C35; A13-B3-C36; A13-B3-C37; A13-B3-C38; A13-B3-C39; A13-B3-C40;

A13-B3-C41; A13-B3-C42; A13-B3-C43; A13-B3-C44; A13-B3-C45; A13-B3-C46;

A14-B3-C1; A14-B3-C2; A14-B3-C3; A14-B3-C4; A14-B3-C5; A14-B3-C6;

A14-B3-C7; A14-B3-C8; A14-B3-C9; A14-B3-C10; A14-B3-Cll; A14-B3-C12;

A14-B3-C13; A14-B3-C14; A14-B3-C15; A14-B3-C16; A14-B3-C17; A14-B3-C18;

A14-B3-C19; A14-B3-C20; A14-B3-C21; A14-B3-C22; A14-B3-C23; A14-B3-C24;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -47A14-B3-C25; A14-B3-C26; A14-B3-C27; A14-B3-C28; A14-B3-C29; A14-B3-C30;

A14-B3-C31; A14-B3-C32; A14-B3-C33; A14-B3-C34; A14-B3-C35; A14-B3-C36;

A14-B3-C37; A14-B3-C38; A14-B3-C39; A14-B3-C40; A14-B3-C41; A14-B3-C42;

A14-B3-C43; A14-B3-C44; A14-B3-C45; A14-B3-C46; A15-B3-C1; A15-B3-C2;

A15-B3-C3; A15-B3-C4; A15-B3-C5; A15-B3-C6; A15-B3-C7; A15-B3-C8;

A15-B3-C9; A15-B3-C10; A15-B3-Cll; A15-B3-C12; A15-B3-C13; A15-B3-C14;

A15-B3-C15; A15-B3-C16; A15-B3-C17; A15-B3-C18; A15-B3-C19; A15-B3-C20;

A15-B3-C21; A15-B3-C22; A15-B3-C23; A15-B3-C24; A15-B3-C25; A15-B3-C26;

A15-B3-C27; A15-B3-C28; A15-B3-C29; A15-B3-C30; A15-B3-C31; A15-B3-C32;

A15-B3-C33; A15-B3-C34; A15-B3-C35; A15-B3-C36; A15-B3-C37; A15-B3-C38;

A15-B3-C39; A15-B3-C40; A15-B3-C41; A15-B3-C42; A15-B3-C43; A15-B3-C44;

A15-B3-C45; A15-B3-C46; A16-B3-C1; A16-B3-C2; A16-B3-C3; A16-B3-C4;

A16-B3-C5; A16-B3-C6; A16-B3-C7; A16-B3-C8; A16-B3-C9; A16-B3-C10;

A16-B3-C11; A16-B3-C12; A16-B3-C13; A16-B3-C14; A16-B3-C15; A16-B3-C16;

A16-B3-C17; A16-B3-C18; A16-B3-C19; A16-B3-C20; A16-B3-C21; A16-B3-C22;

A16-B3-C23; A16-B3-C24; A16-B3-C25; A16-B3-C26; A16-B3-C27; A16-B3-C28;

A16-B3-C29; A16-B3-C30; A16-B3-C31; A16-B3-C32; A16-B3-C33; A16-B3-C34;

A16-B3-C35; A16-B3-C36; A16-B3-C37; A16-B3-C38; A16-B3-C39; A16-B3-C40;

A16-B3-C41; A16-B3-C42; A16-B3-C43; A16-B3-C44; A16-B3-C45; A16-B3-C46;

A17-B3-C1; A17-B3-C2; A17-B3-C3; A17-B3-C4; A17-B3-C5; A17-B3-C6;

A17-B3-C7; A17-B3-C8; A17-B3-C9; A17-B3-C10; A17-B3-C11; A17-B3-C12;

A17-B3-C13; A17-B3-C14; A17-B3-C15; A17-B3-C16; A17-B3-C17; A17-B3-C18;

A17-B3-C19; A17-B3-C20; A17-B3-C21; A17-B3-C22; A17-B3-C23; A17-B3-C24;

A17-B3-C25; A17-B3-C26; A17-B3-C27; A17-B3-C28; A17-B3-C29; A17-B3-C30;

A17-B3-C31; A17-B3-C32; A17-B3-C33; A17-B3-C34; A17-B3-C35; A17-B3-C36;

A17-B3-C37; A17-B3-C38; A17-B3-C39; A17-B3-C40; A17-B3-C41; A17-B3-C42;

A17-B3-C43; A17-B3-C44; A17-B3-C45; A17-B3-C46; A18-B3-Cl; A18-B3-C2;

A18-B3-C3; A18-B3-C4; A18-B3-C5; A18-B3-C6; A18-B3-C7; A18-B3-C8;

A18-B3-C9; A18-B3-C10; A18-B3-C11; A18-B3-C12; A18-B3-C13; A18-B3-C14;

A18-B3-C15; A18-B3-C16; A18-B3-C17; A18-B3-C18; A18-B3-C19; A18-B3-C20;

A18-B3-C21; A18-B3-C22; A18-B3-C23; A18-B3-C24; A18-B3-C25; A18-B3-C26;

A18-B3-C27; A18-B3-C28; A18-B3-C29; A18-B3-C30; A18-B3-C31; A18-B3-C32;

A18-B3-C33; A18-B3-C34; A18-B3-C35; A18-B3-C36; A18-B3-C37; A18-B3-C38;

A18-B3-C39; A18-B3-C40; A18-B3-C41; A18-B3-C42; A18-B3-C43; A18-B3-C44;

A18-B3-C45; A18-B3-C46; A19-B3-Cl; A19-B3-C2; A19-B3-C3; A19-B3-C4;

A19-B3-C5; A19-B3-C6; A19-B3-C7; A19-B3-C8; A19-B3-C9; A19-B3-C10;

A19-B3-C11; A19-B3-C12; A19-B3-C13; A19-B3-C14; A19-B3-C15; A19-B3-C16;

A19-B3-C17; A19-B3-C18; A19-B3-C19; A19-B3-C20; A19-B3-C21; A19-B3-C22;

A19-B3-C23; A19-B3-C24; A19-B3-C25; A19-B3-C26; A19-B3-C27; A19-B3-C28;

A19-B3-C29; A19-B3-C30; A19-B3-C31; A19-B3-C32; A19-B3-C33; A19-B3-C34;

A19-B3-C35; A19-B3-C36; A19-B3-C37; A19-B3-C38; A19-B3-C39; A19-B3-C40;

A19-B3-C41; A19-B3-C42; A19-B3-C43; A19-B3-C44; A19-B3-C45; A19-B3-C46;

A20-B3-C1; A20-B3-C2; A20-B3-C3; A20-B3-C4; A20-B3-C5; A20-B3-C6;

A20-B3-C7; A20-B3-C8; A20-B3-C9; A20-B3-C10; A20-B3-C11; A20-B3-C12;

A20-B3-C13; A20-B3-C14; A20-B3-C15; A20-B3-C16; A20-B3-C17; A20-B3-C18;

A20-B3-C19; A20-B3-C20; A20-B3-C21; A20-B3-C22; A20-B3-C23; A20-B3-C24;

A20-B3-C25; A20-B3-C26; A20-B3-C27; A20-B3-C28; A20-B3-C29; A20-B3-C30;

A20-B3-C31; A20-B3-C32; A20-B3-C33; A20-B3-C34; A20-B3-C35; A20-B3-C36;

A20-B3-C37; A20-B3-C38; A20-B3-C39; A20-B3-C40; A20-B3-C41; A20-B3-C42;

A20-B3-C43; A20-B3-C44; A20-B3-C45; A20-B3-C46; A21-B3-Cl; A21-B3-C2;

A21-B3-C3; A21-B3-C4; A21-B3-C5; A21-B3-C6; A21-B3-C7; A21-B3-C8;

A21-B3-C9; A21-B3-C10; A21-B3-Cll; A21-B3-C12; A21-B3-C13; A21-B3-C14;

A21-B3-C15; A21-B3-C16; A21-B3-C17; A21-B3-C18; A21-B3-C19; A21-B3-C20;

A21-B3-C21; A21-B3-C22; A21-B3-C23; A21-B3-C24; A21-B3-C25; A21-B3-C26;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -48A21-B3-C27; A21-B3-C28; A21-B3-C29; A21-B3-C30; A21-B3-C31; A21-B3-C32;

A21-B3-C33; A21-B3-C34; A21-B3-C35; A21-B3-C36; A21-B3-C37; A21-B3-C38;

A21-B3-C39; A21-B3-C40; A21-B3-C41; A21-B3-C42; A21-B3-C43; A21-B3-C44;

A21-B3-C45; A21-B3-C46; A22-B3-Cl; A22-B3-C2; A22-B3-C3; A22-B3-C4;

A22-B3-C5; A22-B3-C6; A22-B3-C7; A22-B3-C8; A22-B3-C9; A22-B3-C10;

A22-B3-C11; A22-B3-C12; A22-B3-C13; A22-B3-C14; A22-B3-C15; A22-B3-C16;

A22-B3-C17; A22-B3-C18; A22-B3-C19; A22-B3-C20; A22-B3-C21; A22-B3-C22;

A22-B3-C23; A22-B3-C24; A22-B3-C25; A22-B3-C26; A22-B3-C27; A22-B3-C28;

A22-B3-C29; A22-B3-C30; A22-B3-C31; A22-B3-C32; A22-B3-C33; A22-B3-C34;

A22-B3-C35; A22-B3-C36; A22-B3-C37; A22-B3-C38; A22-B3-C39; A22-B3-C40;

A22-B3-C41; A22-B3-C42; A22-B3-C43; A22-B3-C44; A22-B3-C45; A22-B3-C46;

A23-B3-C1; A23-B3-C2; A23-B3-C3; A23-B3-C4; A23-B3-C5; A23-B3-C6;

A23-B3-C7; A23-B3-C8; A23-B3-C9; A23-B3-C10; A23-B3-C11; A23-B3-C12;

A23-B3-C13; A23-B3-C14; A23-B3-C15; A23-B3-C16; A23-B3-C17; A23-B3-C18;

A23-B3-C19; A23-B3-C20; A23-B3-C21; A23-B3-C22; A23-B3-C23; A23-B3-C24;

A23-B3-C25; A23-B3-C26; A23-B3-C27; A23-B3-C28; A23-B3-C29; A23-B3-C30;

A23-B3-C31; A23-B3-C32; A23-B3-C33; A23-B3-C34; A23-B3-C35; A23-B3-C36;

A23-B3-C37; A23-B3-C38; A23-B3-C39; A23-B3-C40; A23-B3-C41; A23-B3-C42;

A23-B3-C43; A23-B3-C44; A23-B3-C45; A23-B3-C46; A24-B3-C1; A24-B3-C2;

A24-B3-C3; A24-B3-C4; A24-B3-C5; A24-B3-C6; A24-B3-C7; A24-B3-C8;

A24-B3-C9; A24-B3-C10; A24-B3-C11; A24-B3-C12; A24-B3-C13; A24-B3-C14;

A24-B3-C15; A24-B3-C16; A24-B3-C17; A24-B3-C18; A24-B3-C19; A24-B3-C20;

A24-B3-C21; A24-B3-C22; A24-B3-C23; A24-B3-C24; A24-B3-C25; A24-B3-C26;

A24-B3-C27; A24-B3-C28; A24-B3-C29; A24-B3-C30; A24-B3-C31; A24-B3-C32;

A24-B3-C33; A24-B3-C34; A24-B3-C35; A24-B3-C36; A24-B3-C37; A24-B3-C38;

A24-B3-C39; A24-B3-C40; A24-B3-C41; A24-B3-C42; A24-B3-C43; A24-B3-C44;

A24-B3-C45; A24-B3-C46; A25-B3-Cl; A25-B3-C2; A25-B3-C3; A25-B3-C4;

A25-B3-C5; A25-B3-C6; A25-B3-C7; A25-B3-C8; A25-B3-C9; A25-B3-C10;

A25-B3-C11; A25-B3-C12; A25-B3-C13; A25-B3-C14; A25-B3-C15; A25-B3-C16;

A25-B3-C17; A25-B3-C18; A25-B3-C19; A25-B3-C20; A25-B3-C21; A25-B3-C22;

A25-B3-C23; A25-B3-C24; A25-B3-C25; A25-B3-C26; A25-B3-C27; A25-B3-C28;

A25-B3-C29; A25-B3-C30; A25-B3-C31; A25-B3-C32; A25-B3-C33; A25-B3-C34;

A25-B3-C35; A25-B3-C36; A25-B3-C37; A25-B3-C38; A25-B3-C39; A25-B3-C40;

A25-B3-C41; A25-B3-C42; A25-B3-C43; A25-B3-C44; A25-B3-C45; A25-B3-C46;

A26-B3-C1; A26-B3-C2; A26-B3-C3; A26-B3-C4; A26-B3-C5; A26-B3-C6;

A26-B3-C7; A26-B3-C8; A26-B3-C9; A26-B3-C10; A26-B3-Cll; A26-B3-C12;

A26-B3-C13; A26-B3-C14; A26-B3-C15; A26-B3-C16; A26-B3-C17; A26-B3-C18;

A26-B3-C19; A26-B3-C20; A26-B3-C21; A26-B3-C22; A26-B3-C23; A26-B3-C24;

A26-B3-C25; A26-B3-C26; A26-B3-C27; A26-B3-C28; A26-B3-C29; A26-B3-C30;

A26-B3-C31; A26-B3-C32; A26-B3-C33; A26-B3-C34; A26-B3-C35; A26-B3-C36;

A26-B3-C37; A26-B3-C38; A26-B3-C39; A26-B3-C40; A26-B3-C41; A26-B3-C42;

A26-B3-C43; A26-B3-C44; A26-B3-C45; A26-B3-C46; A27-B3-C1; A27-B3-C2;

A27-B3-C3; A27-B3-C4; A27-B3-C5; A27-B3-C6; A27-B3-C7; A27-B3-C8;

A27-B3-C9; A27-B3-C10; A27-B3-C11; A27-B3-C12; A27-B3-C13; A27-B3-C14;

A27-B3-C15; A27-B3-C16; A27-B3-C17; A27-B3-C18; A27-B3-C19; A27-B3-C20;

A27-B3-C21; A27-B3-C22; A27-B3-C23; A27-B3-C24; A27-B3-C25; A27-B3-C26;

A27-B3-C27; A27-B3-C28; A27-B3-C29; A27-B3-C30; A27-B3-C31; A27-B3-C32;

A27-B3-C33; A27-B3-C34; A27-B3-C35; A27-B3-C36; A27-B3-C37; A27-133-C38;

A27-B3-C39; A27-B3-C40; A27-B3-C41; A27-B3-C42; A27-B3-C43; A27-B3-C44;

A27-B3-C45; A27-B3-C46; A28-B3-Cl; A28-B3-C2; A28-B3-C3; A28-B3-C4;

A28-B3-C5; A28-B3-C6; A28-B3-C7; A28-B3-C8; A28-B3-C9; A28-B3-C10;

A28-B3-C11; A28-B3-C12; A28-B3-C13; A28-B3-C14; A28-B3-C15; A28-B3-C16;

A28-B3-C17; A28-B3-C18; A28-B3-C19; A28-B3-C20; A28-B3-C21; A28-B3-C22;

A28-B3-C23; A28-B3-C24; A28-B3-C25; A28-B3-C26; A28-B3-C27; A28-B3-C28;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -49A28-B3-C29; A28-B3-C30; A28-B3-C31; A28-B3-C32; A28-B3-C33; A28-B3-C34;

A28-B3-C35; A28-B3-C36; A28-B3-C37; A28-B3-C38; A28-B3-C39; A28-B3-C40;

A28-B3-C41; A28-B3-C42; A28-B3-C43; A28-B3-C44; A28-B3-C45; A28-B3-C46;

Al-B4-Cl; Al-B4-C2; Al-B4-C3; Al-B4-C4; Al-B4-C5; Al-B4-C6;

Al-B4-C7; Al-B4-C8; Al-B4-C9; Al-B4-C10; Al-B4-C11; Al-B4-C12;

Al-B4-C13; Al-B4-C14; Al-B4-C15; Al-B4-C16; Al-B4-C17; Al-B4-C18;

Al-B4-C19; Al-B4-C20; Al-B4-C21; Al-B4-C22; Al-B4-C23; Al-B4-C24;

Al-B4-C25; Al-B4-C26; Al-B4-C27; Al-B4-C28; Al-B4-C29; Al-B4-C30;

Al-B4-C31; Al-B4-C32; Al-B4-C33; Al-B4-C34; Al-B4-C35; Al-B4-C36;

Al-B4-C37; Al-B4-C38; Al-B4-C39; Al-B4-C40; Al-B4-C41; Al-B4-C42;

Al-B4-C43;.

Al-B4-C44; Al-B4-C45; Al-B4-C46; A2-B4-C1; A2-B4-C2;

A2-B4-C3; A2-B4-C4; A2-B4-C5; A2-B4-C6; A2-B4-C7; A2-B4-C8;

A2-B4-C9; A2-B4-C10; A2-B4-C11; A2-B4-C12; A2-B4-C13; A2-B4-C14;

A2-B4-C15; A2-B4-C16; A2-B4-C17; A2-B4-C18; A2-B4-C19; A2-B4-C20;

A2-B4-C21; A2-B4-C22; A2-B4-C23; A2-B4-C24; A2-B4-C25; A2-B4-C26;

A2-B4-C27; A2-B4-C28; A2-B4-C29; A2-B4-C30; A2-B4-C31; A2-B4-C32;

A2-B4-C33; A2-B4-C34; A2-B4-C35; A2-B4-C36; A2-B4-C37; A2-B4-C38;

A2-B4-C39; A2-B4-C40; A2-B4-C41; A2-B4-C42; A2-B4-C43; A2-B4-C44;

A2-B4-C45; A2-B4-C46; A3-B4-C1; A3-B4-C2; A3-B4-C3; A3-B4-C4;

A3-B4-C5; A3-B4-C6; A3-B4-C7; A3-B4-C8; A3-B4-C9; A3-B4-C10;

A3-B4-C11; A3-B4-C12; A3-B4-C13; A3-B4-C14; A3-B4-C15; A3-B4-C16;

A3-B4-C17; A3-B4-C18; A3-B4-C19; A3-B4-C20; A3-B4-C21; A3-B4-C22;

A3-B4-C23; A3-B4-C24; A3-B4-C25; A3-B4-C26; A3-B4-C27; A3-B4-C28;

A3-B4-C29; A3-B4-C30; A3-B4-C31; A3-B4-C32; A3-B4-C33; A3-B4-C34;

A3-B4-C35; A3-B4-C36; A3-B4-C37; A3-B4-C38; A3-B4-C39; A3-B4-C40;

A3-B4-C41; A3-B4-C42; A3-B4-C43; A3-B4-C44; A3-B4-C45; A3-B4-C46;

A4-B4-Cl; A4-B4-C2; A4-B4-C3; A4-B4-C4; A4-B4-C5; A4-B4-C6;

A4-B4-C7; A4-B4-C8; A4-B4-C9; A4-B4-C10; A4-B4-C11; A4-B4-C12;

A4-B4-C13; A4-B4-C14; A4-B4-C15; A4-B4-C16; A4-B4-C17; A4-B4-C18;

A4-B4-C19; A4-B4-C20; A4-B4-C21; A4-B4-C22; A4-B4-C23; A4-B4-C24;

A4-B4-C25; A4-B4-C26; A4-B4-C27; A4-B4-C28; A4-B4-C29; A4-B4-C30;

A4-B4-C31; A4-B4-C32; A4-B4-C33; A4-B4-C34; A4-B4-C35; A4-B4-C36;

A4-B4-C37; A4-B4-C38; A4-B4-C39; A4-B4-C40; A4-B4-C41; A4-B4-C42;

A4-B4-C43; A4-B4-C44; A4-B4-C45; A4-B4-C46; A5-B4-Cl; A5-B4-C2;

A5-B4-C3; A5-B4-C4; A5-B4-C5; A5-B4-C6; A5-B4-C7; A5-B4-C8;

A5-B4-C9; A5-B4-C10; A5-B4-C11; A5-B4-C12; A5-B4-C13; A5-B4-C14;

A5-B4-C15; A5-B4-C16; A5-B4-C17; A5-B4-C18; A5-B4-C19; A5-B4-C20;

A5-B4-C21; A5-B4-C22; A5-B4-C23; A5-B4-C24; A5-B4-C25; A5-B4-C26;

A5-B4-C27; A5-B4-C28; A5-B4-C29; A5-B4-C30; A5-B4-C31; A5-B4-C32;

A5-B4-C33; A5-B4-C34; A5-B4-C35; A5-B4-C36; A5-B4-C37; A5-B4-C38;

A5-B4-C39; A5-B4-C40; A5-B4-C41; A5-B4-C42; A5-B4-C43; A5-B4-C44;

A5-B4-C45; A5-B4-C46; A6-B4-Cl; A6-B4-C2; A6-B4-C3; A6-B4-C4;

A6-B4-C5; A6-B4-C6; A6-B4-C7; A6-B4-C8; A6-B4-C9; A6-B4-C10;

A6-B4-C11; A6-B4-C12; A6-B4-C13; A6-B4-C14; A6-B4-C15; A6-B4-C16;

A6-B4-C17; A6-B4-C18; A6-B4-C19; A6-B4-C20; A6-B4-C21; A6-B4-C22;

A6-B4-C23; A6-B4-C24; A6-B4-C25; A6-B4-C26; A6-B4-C27; A6-B4-C28;

A6-B4-C29; A6-B4-C30; A6-B4-C31; A6-B4-C32; A6-B4-C33; A6-B4-C34;

A6-B4-C35; A6-B4-C36; A6-B4-C37; A6-B4-C38; A6-B4-C39; A6-B4-C40;

A6-B4-C41; A6-B4-C42; A6-B4-C43; A6-B4-C44; A6-B4-C45; A6-B4-C46;

A7-B4-C1; A7-B4-C2; A7-B4-C3; A7-B4-C4; A7-B4-C5; A7-B4-C6;

A7-B4-C7; A7-B4-C8; A7-B4-C9; A7-B4-C10; A7-B4-C11; A7-B4-C12;

A7-B4-C13; A7-B4-C14; A7-B4-C15; A7-B4-C16; A7-B4-C17; A7-B4-C18;

A7-B4-C19; A7-B4-C20; A7-B4-C21; A7-B4-C22; A7-B4-C23; A7-B4-C24;

A7-B4-C25; A7-B4-C26; A7-B4-C27; A7-B4-C28; A7-B4-C29; A7-B4-C30;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -50A7-B4-C31; A7-B4-C32; A7-B4-C33; A7-B4-C34; A7-B4-C35; A7-B4-C36;

A7-B4-C37; A7-B4-C38; A7-B4-C39; A7-B4-C40; A7-B4-C41; A7-B4-C42;

A7-B4-C43; A7-B4-C44; A7-B4-C45; A7-B4-C46; A8-B4-C1; A8-B4-C2;

A8-B4-C3; A8-B4-C4; A8-B4-C5; . A8-B4-C6; A8-B4-C7; A8-B4-C8;

A8-B4-C9; A8-B4-C10; A8-B4-C11; A8-B4-C12; A8-B4-C13; A8-B4-C14;

A8-B4-C15; A8-B4-C16; A8-B4-C17; A8-B4-C18; A8-B4-C19; A8-B4-C20;

A8-B4-C21; A8-B4-C22; A8-B4-C23; A8-B4-C24; A8-B4-C25; A8-B4-C26;

A8-B4-C27; A8-B4-C28; A8-B4-C29; A8-B4-C30; A8-B4-C31; A8-B4-C32;

A8-B4-C33; A8-B4-C34; A8-B4-C35; A8-B4-C36; A8-B4-C37; A8-B4-C38;

A8-B4-C39; A8-B4-C40; A8-B4-C41; A8-B4-C42; A8-B4-C43; A8-B4-C44;

A8-B4-C45; A8-B4-C46; A9-B4-C1; A9-B4-C2; A9-B4-C3; A9-B4-C4;

A9-B4-C5; A9-B4-C6; A9-B4-C7; A9-B4-C8; A9-B4-C9; A9-B4-C10;

A9-B4-C11; A9-B4-C12; A9-B4-C13; A9-B4-C14; A9-B4-C15; A9-B4-C16;

A9-B4-C17; A9-B4-C18; A9-B4-C19; A9-B4-C20; A9-B4-C21; A9-B4-C22;

A9-B4-C23; A9-B4-C24; A9-B4-C25; A9-B4-C26; A9-B4-C27; A9-B4-C28;

A9-B4-C29; A9-B4-C30; A9-B4-C31; A9-B4-C32; A9-B4-C33; A9-B4-C34;

A9-B4-C35; A9-B4-C36; A9-B4-C37; A9-B4-C38; A9-B4-C39; A9-B4-C40;

A9-B4-C41; A9-B4-C42; A9-B4-C43; A9-B4-C44; A9-B4-C45; A9-B4-C46;

A10-B4-C1; A10-B4-C2; A10-B4-C3; A10-B4-C4; A10-B4-C5; A10-B4-C6;

A10-B4-C7; A10-B4-C8; A10-B4-C9; A10-B4-C10; A10-B4-C11; A10-B4-C12;

A10-B4-C13; A10-B4-C14; A10-B4-C15; A10-B4-C16; A10-B4-C17; A10-B4-C18;

A10-B4-C19; A10-B4-C20; A10-B4-C21; A10-B4-C22; A10-B4-C23; A10-B4-C24;

A10-B4-C25; A10-B4-C26; A10-B4-C27; A10-B4-C28; A10-B4-C29; A10-B4-C30;

A10-B4-C31; A10-B4-C32; A10-B4-C33; A10-B4-C34; A10-B4-C35; A10-B4-C36;

A10-B4-C37; A10-B4-C38; A10-B4-C39; A10-B4-C40; A10-B4-C41; A10-B4-C42;

A10-B4-C43; A10-B4-C44; A10-B4-C45; A10-B4-C46; All-B4-Cl; All-B4-C2;

All-B4-C3; All-B4-C4; All-B4-C5; All-B4-C6; All-B4-C7; All-B4-C8;

All-B4-C9; All-B4-C10; All-B4-C11; All-B4-C12; All-B4-C13; All-B4-C14;

All-B4-C15; All-B4-C16; All-B4-C17; All-B4-C18; All-B4-C19; All-B4-C20;

All-B4-C21; All-B4-C22; All-B4-C23; All-B4-C24; All-B4-C25; All-B4-C26;

All-B4-C27; All-B4-C28; All-B4-C29; All-B4-C30; All-B4-C31; All-B4-C32;

All-B4-C33; All-B4-C34; All-B4-C35; All-B4-C36; All-B4-C37; All-B4-C38;

All-B4-C39; All-B4-C40; All-B4-C41; All-B4-C42; All-B4-C43; All-B4-C44;

All-B4-C45; All-B4-C46; A12-B4-C1; A12-B4-C2; A12-B4-C3; A12-B4-C4;

A12-B4-C5; A12-B4-C6; A12-B4-C7; A12-B4-C8; A12-B4-C9; A12-B4-C10;

A12-B4-C11; A12-B4-C12; A12-B4-C13; A12-B4-C14; A12-B4-C15; A12-B4-C16;

A12-B4-C17; A12-B4-C18; A12-B4-C19; A12-B4-C20; A12-B4-C21; A12-B4-C22;

A12-B4-C23; A12-B4-C24; A12-B4-C25; A12-B4-C26; A12-B4-C27; A12-B4-C28;

A12-B4-C29; A12-B4-C30; A12-B4-C31; A12-B4-C32; A12-B4-C33; A12-B4-C34;

A12-B4-C35; A12-B4-C36; A12-B4-C37; A12-B4-C38; A12-B4-C39; A12-B4-C40;

A12-B4-C41; A12-B4-C42; A12-B4-C43; A12-B4-C44; A12-B4-C45; A12-B4-C46;

A13-B4-C1; A13-B4-C2; A13-B4-C3; A13-B4-C4; A13-B4-C5; A13-B4-C6;

A13-B4-C7; A13-B4-C8; A13-B4-C9; A13-B4-C10; A13-B4-Cll; A13-B4-C12;

A13-B4-C13; A13-B4-C14; A13-B4-C15; A13-B4-C16; A13-B4-C17; A13-B4-C18;

A13-B4-C19; A13-B4-C20; A13-B4-C21; A13-B4-C22; A13-B4-C23; A13-B4-C24;

A13-B4-C25; A13-B4-C26; A13-B4-C27; A13-B4-C28; A13-B4-C29; A13-B4-C30;

A13-B4-C31; A13-B4-C32; A13-B4-C33; A13-B4-C34; A13-B4-C35; A13-B4-C36;

A13-B4-C37; A13-B4-C38; A13-B4-C39; A13-B4-C40; A13-B4-C41; A13-B4-C42;

A13-B4-C43; A13-B4-C44; A13-B4-C45; A13-B4-C46; A14-B4-Cl; A14-B4-C2;

A14-B4-C3; A14-B4-C4; A14-B4-C5; A14-B4-C6; A14-B4-C7; A14-B4-C8;

A14-B4-C9; A14-B4-C10; A14-B4-Cl1; A14-B4-C12; A14-B4-C13; A14-B4-C14;

A14-B4-C15; A14-B4-C16; A14-B4-C17; A14-B4-C18; A14-B4-C19; A14-B4-C20;

A14-B4-C21; A14-B4-C22; A14-B4-C23; A14-B4-C24; A14-B4-C25; A14-B4-C26;

A14-B4-C27; A14-B4-C28; A14-B4-C29; A14-B4-C30; A14-B4-C31; A14-B4-C32;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -51A14-B4-C33; A14-B4-C34; A14-B4-C35; A14-B4-C36; A14-B4-C37; A14-B4-C38;

A14-B4-C39; A14-B4-C40; A14-B4-C41; A14-B4-C42; A14-B4-C43; A14-B4-C44;

A14-B4-C45; A14-B4-C46; A15-B4-C1; A15-B4-C2; A15-B4-C3; A15-B4-C4;

A15-B4-C5; A15-B4-C6; A15-B4-C7; A15-B4-C8; A15-B4-C9; A15-B4-C10;

A15-B4-Cll; A15-B4-C12; A15-B4-C13; A15-B4-C14; A15-B4-C15; A15-B4-C16;

A15-B4-C17; A15-B4-C18; A15-B4-C19; A15-B4-C20; A15-B4-C21; A15-B4-C22;

A15-B4-C23; A15-B4-C24; A15-B4-C25; A15-B4-C26; A15-B4-C27; A15-B4-C28;

A15-B4-C29; A15-B4-C30; A15-B4-C31; A15-B4-C32; A15-B4-C33; A15-B4-C34;

A15-B4-C35; A15-B4-C36; A15-B4-C37; A15-B4-C38; A15-B4-C39; A15-B4-C40;

A15-B4-C41; A15-B4-C42; A15-B4-C43; A15-B4-C44; A15-B4-C45; A15-B4-C46;

A16-B4-CI; A16-B4-C2; A16-B4-C3; A16-B4-C4; A16-B4-C5; A16-B4-C6;

A16-B4-C7; A16-B4-C8; A16-B4-C9; A16-B4-C10; A16-B4-C11; A16-B4-C12;

A16-B4-C13; A16-B4-C14; A16-B4-C15; A16-B4-C16; A16-B4-C17; A16-B4-C18;

A16-B4-C19; A16-B4-C20; A16-B4-C21; A16-B4-C22; A16-B4-C23; A16-B4-C24;

A16-B4-C25; A16-B4-C26; A16-B4-C27; A16-B4-C28; A16-B4-C29; A16-B4-C30;

A16-B4-C31; A16-B4-C32; A16-B4-C33; A16-B4-C34; A16-B4-C35; A16-B4-C36;

A16-B4-C37; A16-B4-C38; A16-B4-C39; A16-B4-C40; A16-B4-C41; A16-B4-C42;

A16-B4-C43; A16-B4-C44; A16-B4-C45; A16-B4-C46; A17-B4-C1; A17-B4-C2;

A17-B4-C3; A17-B4-C4; A17-B4-C5; A17-B4-C6; A17-B4-C7; A17-B4-C8;

A17-B4-C9; A17-B4-C10; A17-B4-C11; A17-B4-C12; A17-B4-C13; A17-B4-C14;

A17-B4-C15; A17-B4-C16; A17-B4-C17; A17-B4-C18; A17-B4-C19; A17-B4-C20;

A17-B4-C21; A17-B4-C22; A17-B4-C23; A17-B4-C24; A17-B4-C25; A17-B4-C26;

A17-B4-C27; A17-B4-C28; A17-B4-C29; A17-B4-C30; A17-B4-C31; A17-B4-C32;

A17-B4-C33; A17-B4-C34; A17-B4-C35; A17-B4-C36; A17-B4-C37; A17-B4-C38;

A17-B4-C39; A17-B4-C40; A17-B4-C41; A17-B4-C42; A17-B4-C43; A17-B4-C44;

A17-B4-C45; A17-B4-C46; A18-B4-Cl; A18-B4-C2; A18-B4-C3; A18-B4-C4;

A18-B4-C5; A18-B4-C6; A18-B4-C7; A18-B4-C8; A18-B4-C9; A18-B4-C10;

A18-B4-C11; A18-B4-C12; A18-B4-C13; A18-B4-C14; A18-B4-C15; A18-B4-C16;

A18-B4-C17; A18-B4-C18; A18-B4-C19; A18-B4-C20; A18-B4-C21; A18-B4-C22;

A18-B4-C23; A18-B4-C24; A18-B4-C25; A18-B4-C26; A18-B4-C27; A18-B4-C28;

A18-B4-C29; A18-B4-C30; A18-B4-C31; A18-B4-C32; A18-B4-C33; A18-B4-C34;

A18-B4-C35; A18-B4-C36; A18-B4-C37; A18-B4-C38; A18-B4-C39; A18-B4-C40;

A18-B4-C41; A18-B4-C42; A18-B4-C43; A18-B4-C44; A18-B4-C45; A18-B4-C46;

A19-B4-Cl; A19-B4-C2; A19-B4-C3; A19-B4-C4; A19-B4-C5; A19-B4-C6;

A19-B4-C7; A19-B4-C8; A19-B4-C9; A19-B4-C10; A19-B4-C11; A19-B4-C12;

A19-B4-C13; A19-B4-C14; A19-B4-C15; A19-B4-C16; A19-B4-C17; A19-B4-C18;

A19-B4-C19; A19-B4-C20; A19-B4-C21; A19-B4-C22; A19-B4-C23; A19-B4-C24;

A19-B4-C25; A19-B4-C26; A19-B4-C27; A19-B4-C28; A19-B4-C29; A19-B4-C30;

A19-B4-C31; A19-B4-C32; A19-B4-C33; A19-B4-C34; A19-B4-C35; A19-B4-C36;

A19-B4-C37; A19-B4-C38; A19-B4-C39; A19-B4-C40; A19-B4-C41; A19-B4-C42;

A19-B4-C43; A19-B4-C44; A19-B4-C45; A19-B4-C46; A20-B4-C1; A20-B4-C2;

A20-B4-C3; A20-B4-C4; A20-B4-C5; A20-B4-C6; A20-B4-C7; A20-B4-C8;

A20-B4-C9; A20-B4-C10; A20-B4-C11; A20-B4-C12; A20-B4-C13; A20-B4-C14;

A20-B4-C15; A20-B4-C16; A20-B4-C17; A20-B4-C18; A20-B4-C19; A20-B4-C20;

A20-B4-C21; A20-B4-C22; A20-B4-C23; A20-B4-C24; A20-B4-C25; A20-B4-C26;

A20-B4-C27; A20-B4-C28; A20-B4-C29; A20-B4-C30; A20-B4-C31; A20-B4-C32;

A20-B4-C33; A20-B4-C34; A20-B4-C35; A20-B4-C36; A20-B4-C37; A20-B4-C38;

A20-B4-C39; A20-B4-C40; A20-B4-C41; A20-B4-C42; A20-B4-C43; A20-B4-C44;

A20-B4-C45; A20-B4-C46; A21-B4-C1; A21-B4-C2; A21-B4-C3; A21-B4-C4;

A21-B4-C5; A21-B4-C6; A21-B4-C7; A21-B4-C8; A21-B4-C9; A21-B4-C10;

A21-B4-C11; A21-B4-C12; A21-B4-C13; A21-B4-C14; A21-B4-C15; A21-B4-C16;

A21-B4-C17; A21-B4-C18; A21-B4-C19; A21-B4-C20; A21-B4-C21; A21-134-C22;

A21-B4-C23; A21-B4-C24; A21-B4-C25; A21-B4-C26; A21-B4-C27; A21-134-C28;

A21-B4-C29; A21-B4-C30; A21-B4-C31; A21-B4-C32; A21-B4-C33; A21-134-C34;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -52A21-B4-C35; A21-B4-C36; A21-B4-C37; A21-B4-C38; A21-B4-C39; A21-B4-C40;

A21-B4-C41; A21-B4-C42; A21-B4-C43; A21-B4-C44; A21-B4-C45; A21-B4-C46;

A22-B4-C1; A22-B4-C2; A22-B4-C3; A22-B4-C4; A22-B4-C5; A22-B4-C6;

A22-B4-C7; A22-B4-C8; A22-B4-C9; A22-B4-C10; A22-B4-C11; A22-B4-C12;

A22-B4-C13; A22-B4-C14; A22-B4-C15; A22-B4-C16; A22-B4-C17; A22-B4-C18;

A22-B4-C19; A22-B4-C20; A22-B4-C21; A22-B4-C22; A22-B4-C23; A22-B4-C24;

A22-B4-C25; A22-B4-C26; A22-B4-C27; A22-B4-C28; A22-B4-C29; A22-B4-C30;

A22-B4-C31; A22-B4-C32; A22-B4-C33; A22-B4-C34; A22-B4-C35; A22-B4-C36;

A22-B4-C37; A22-B4-C38; A22-B4-C39; A22-B4-C40; A22-B4-C41; A22-B4-C42;

A22-B4-C43; A22-B4-C44; A22-B4-C45; A22-B4-C46; A23-B4-Cl; A23-B4-C2;

A23-B4-C3; A23-B4-C4; A23-B4-C5; A23-B4-C6; A23-B4-C7; A23-B4-C8;

A23-B4-C9; A23-B4-C10; A23-B4-C11; A23-B4-C12; A23-B4-C13; A23-B4-C14;

A23-B4-C15; A23-B4-C16; A23-B4-C17; A23-B4-C18; A23-B4-C19; A23-B4-C20;

A23-B4-C21; A23-B4-C22; A23-B4-C23; A23-B4-C24; A23-B4-C25; A23-B4-C26;

A23-B4-C27; A23-B4-C28; A23-B4-C29; A23-B4-C30; A23-B4-C31; A23-B4-C32;

A23-B4-C33; A23-B4-C34; A23-B4-C35; A23-B4-C36; A23-B4-C37; A23-B4-C38;

A23-B4-C39; A23-B4-C40; A23-B4-C41; A23-B4-C42; A23-B4-C43; A23-B4-C44;

A23-B4-C45; A23-B4-C46; A24-B4-C1; A24-B4-C2; A24-B4-C3; A24-B4-C4;

A24-B4-C5; A24-B4-C6; A24-B4-C7; A24-B4-C8; A24-B4-C9; A24-B4-C10;

A24-B4-C11; A24-B4-C12; A24-B4-C13; A24-B4-C14; A24-B4-C15; A24-B4-C16;

A24-B4-C17; A24-B4-C18; A24-B4-C19; A24-B4-C20; A24-B4-C21; A24-B4-C22;

A24-B4-C23; A24-B4-C24; A24-B4-C25; A24-B4-C26; A24-B4-C27; A24-B4-C28;

A24-B4-C29; A24-B4-C30; A24-B4-C31; A24-B4-C32; A24-B4-C33; A24-B4-C34;

A24-B4-C35; A24-B4-C36; A24-B4-C37; A24-B4-C38; A24-B4-C39; A24-B4-C40;

A24-B4-C41; A24-B4-C42; A24-B4-C43; A24-B4-C44; A24-B4-C45; A24-B4-C46;

A25-B4-Cl; A25-B4-C2; A25-B4-C3; A25-B4-C4; A25-B4-C5; A25-B4-C6;

A25-B4-C7; A25-B4-C8; A25-B4-C9; A25-B4-C10; A25-B4-C11; A25-B4-C12;

A25-B4-C13; A25-B4-C14; A25-B4-C15; A25-B4-C16; A25-B4-C17; A25-B4-C18;

A25-B4-C19; A25-B4-C20; A25-B4-C21; A25-B4-C22; A25-B4-C23; A25-B4-C24;

A25-B4-C25; A25-B4-C26; A25-B4-C27; A25-B4-C28; A25-B4-C29; A25-B4-C30;

A25-B4-C31; A25-B4-C32; A25-B4-C33; A25-B4-C34; A25-B4-C35; A25-B4-C36;

A25-B4-C37; A25-B4-C38; A25-B4-C39; A25-B4-C40; A25-B4-C41; A25-B4-C42;

A25-B4-C43; A25-B4-C44; A25-B4-C45; A25-B4-C46; A26-B4-C1; A26-B4-C2;

A26-B4-C3; A26-B4-C4; A26-B4-C5; A26-B4-C6; A26-B4-C7; A26-B4-C8;

A26-B4-C9; A26-B4-C10; A26-B4-C11; A26-B4-C12; A26-B4-C13; A26-B4-C14;

A26-B4-C15; A26-B4-C16; A26-B4-C17; A26-B4-C18; A26-B4-C19; A26-B4-C20;

A26-B4-C21; A26-B4-C22; A26-B4-C23; A26-B4-C24; A26-B4-C25; A26-B4-C26;

A26-B4-C27; A26-B4-C28; A26-B4-C29; A26-B4-C30; A26-B4-C31; A26-B4-C32;

A26-B4-C33; A26-B4-C34; A26-B4-C35; A26-B4-C36; A26-B4-C37; A26-B4-C38;

A26-B4-C39; A26-B4-C40; A26-B4-C41; A26-B4-C42; A26-B4-C43; A26-B4-C44;

A26-B4-C45; A26-B4-C46; A27-B4-C1; A27-B4-C2; A27-B4-C3; A27-B4-C4;

A27-B4-C5; A27-B4-C6; A27-B4-C7; A27-B4-C8; A27-B4-C9; A27-B4-C10;

A27-B4-C11; A27-B4-C12; A27-B4-C13; A27-B4-C14; A27-B4-C15; A27-B4-C16;

A27-B4-C17; A27-B4-C18; A27-B4-C19; A27-B4-C20; A27-B4-C21; A27-B4-C22;

A27-B4-C23; A27-B4-C24; A27-B4-C25; A27-B4-C26; A27-B4-C27; A27-B4-C28;

A27-B4-C29; A27-B4-C30; A27-B4-C31; A27-B4-C32; A27-B4-C33; A27-B4-C34;

A27-B4-C35; A27-B4-C36; A27-B4-C37; A27-B4-C38; A27-B4-C39; A27-B4-C40;

A27-B4-C41; A27-B4-C42; A27-B4-C43; A27-B4-C44; A27-B4-C45; A27-B4-C46;

A28-B4-Cl; A28-B4-C2; A28-B4-C3; A28-B4-C4; A28-B4-C5; A28-B4-C6;

A28-B4-C7; A28-B4-C8; A28-B4-C9; A28-B4-C10; A28-B4-C11; A28-B4-C12;

A28-B4-C13; A28-B4-C14; A28-B4-C15; A28-B4-C16; A28-B4-C17; A28-B4-C18;

A28-B4-C19; A28-B4-C20; A28-B4-C21; A28-B4-C22; A28-B4-C23; A28-B4-C24;

A28-B4-C25; A28-B4-C26; A28-B4-C27; A28-B4-C28; A28-B4-C29; A28-B4-C30;

A28-B4-C31; A28-B4-C32; A28-B4-C33; A28-B4-C34; A28-B4-C35; A28-B4-C36;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -53A28-B4-C37; A28-B4-C38; A28-B4-C39; A28-B4-C40; A28-B4-C41; A28-B4-C42;

A28-B4-C43; A28-B4-C44; A28-B4-C45; A28-B4-C46; Al-B5-Cl; Al-B5-C2;

Al-B5-C3; A1-B5-C4; Al-B5-C5; Al-B5-C6; Al-B5-C7; Al-B5-C8;

Al-B5-C9; Al-B5-C10; Al-B5-Cll; Al-B5-C12; Al-B5-C13; Al-B5-C14;

Al-B5-C15; Al-B5-C16; Al-B5-C17; Al-B5-C18; Al-B5-C19; Al-B5-C20;

Al-B5-C21; Al-B5-C22; Al-B5-C23; Al-B5-C24; Al-B5-C25; Al-B5-C26;

Al-B5-C27; Al-B5-C28; Al-B5-C29; Al-B5-C30; Al-B5-C31; Al-B5-C32;

Al-B5-C33; Al-B5-C34; Al-B5-C35; Al-B5-C36; Al-B5-C37; Al-B5-C38;

Al-B5-C39; Al-B5-C40; Al-B5-C41; Al-B5-C42; Al-B5-C43; Al-B5-C44;

Al-B5-C45; Al-B5-C46; A2-B5-Cl; A2-B5-C2; A2-B5-C3; A2-B5-C4;

A2-B5-C5; A2-B5-C6; A2-B5-C7; A2-B5-C8; A2-B5-C9; A2-B5-C10;

A2-B5-C11; A2-B5-C12;' A2-B5-C13; A2-B5-C14; A2-B5-C15; A2-B5-C16;

A2-B5-C17; A2-B5-C18; A2-B5-C19; A2-B5-C20; A2-B5-C21; A2-B5-C22;

A2-B5-C23; A2-B5-C24; A2-B5-C25; A2-B5-C26; A2-B5-C27; A2-B5-C28;

A2-B5-C29; A2-B5-C30; A2-B5-C31; A2-B5-C32; A2-B5-C33; A2-B5-C34;

A2-B5-C35; A2-B5-C36; A2-B5-C37; A2-B5-C38; A2-B5-C39; A2-B5-C40;

A2-B5-C41; A2-B5-C42; A2-B5-C43; A2-B5-C44; A2-B5-C45; A2-B5-C46;

A3-B5-C1; A3-B5-C2; A3-B5-C3; A3-B5-C4; A3-B5-C5; A3-B5-C6;

A3-B5-C7; A3-B5-C8; A3-B5-C9; A3-B5-C10; A3-B5-C11; A3-B5-C12;

A3-B5-C13; A3-B5-C14; A3-B5-C15; A3-B5-C16; A3-B5-C17; A3-B5-C18;

A3-B5-C19; A3-B5-C20; A3-B5-C21; A3-B5-C22; A3-B5-C23; A3-B5-C24;

A3-B5-C25; A3-B5-C26; A3-B5-C27; A3-B5-C28; A3-B5-C29; A3-B5-C30;

A3-B5-C31; A3-B5-C32; A3-B5-C33; A3-B5-C34; A3-B5-C35; A3-B5-C36;

A3-B5-C37; A3-B5-C38; A3-B5-C39; A3-B5-C40; A3-B5-C41; A3-B5-C42;

A3-B5-C43; A3-B5-C44; A3-B5-C45; A3-B5-C46; A4-B5-C1; A4-B5-C2;

A4-B5-C3; A4-B5-C4; A4-B5-C5; A4-B5-C6; A4-B5-C7; A4-B5-C8;

A4-B5-C9; A4-B5-C10; A4-B5-C11; A4-B5-C12; A4-B5-C13; A4-B5-C14;

A4-B5-C15; A4-B5-C16; A4-B5-C17; A4-B5-C18; A4-B5-C19; A4-B5-C20;

A4-B5-C21; A4-B5-C22; A4-B5-C23; A4-B5-C24; A4-B5-C25; A4-B5-C26;

A4-B5-C27; A4-B5-C28; A4-B5-C29; A4-B5-C30; A4-B5-C31; A4-B5-C32;

A4-B5-C33; A4-B5-C34; A4-B5-C35; A4-B5-C36; A4-B5-C37; A4-B5-C38;

A4-B5-C39; A4-B5-C40; A4-B5-C41; A4-B5-C42; A4-B5-C43; A4-B5-C44;

A4-B5-C45; A4-B5-C46; A5-B5-C1; A5-B5-C2; A5-B5-C3; A5-B5-C4;

A5-B5-C5; A5-B5-C6; A5-B5-C7; A5-B5-C8; A5-B5-C9; A5-B5-C10;

A5-B5-C11; A5-B5-C12; A5-B5-C13; A5-B5-C14; A5-B5-C15; A5-B5-C16;

A5-B5-C17; A5-B5-C18; A5-B5-C19; A5-B5-C20; A5-B5-C21; A5-B5-C22;

A5-B5-C23; A5-B5-C24; A5-B5-C25; A5-B5-C26; A5-B5-C27; A5-B5-C28;

A5-B5-C29; A5-B5-C30; A5-B5-C31; A5-B5-C32; A5-B5-C33; A5-B5-C34;

A5-B5-C35; A5-B5-C36; A5-B5-C37; A5-B5-C38; A5-B5-C39; A5-B5-C40;

A5-B5-C41; A5-B5-C42; A5-B5-C43; A5-B5-C44; A5-B5-C45; A5-B5-C46;

A6-B5-Cl; A6-B5-C2; A6-B5-C3; A6-B5-C4; A6-B5-C5; A6-B5-C6;

A6-B5-C7; A6-B5-C8; A6-B5-C9; A6-B5-C10; A6-B5-C11; A6-B5-C12;

A6-B5-C13; A6-B5-C14; A6-B5-C15; A6-B5-C16; A6-B5-C17; A6-B5-C18;

A6-B5-C19; A6-B5-C20; A6-B5-C21; A6-B5-C22; A6-B5-C23; A6-B5-C24;

A6-B5-C25; A6-B5-C26; A6-B5-C27; A6-B5-C28; A6-B5-C29; A6-B5-C30;

A6-B5-C31; A6-B5-C32; A6-B5-C33; A6-B5-C34; A6-B5-C35; A6-B5-C36;

A6-B5-C37; A6-B5-C38; A6-B5-C39; A6-B5-C40; A6-B5-C41; A6-B5-C42;

A6-B5-C43; A6-B5-C44; A6-B5-C45; A6-B5-C46; A7-B5-C1; A7-B5-C2;

A7-B5-C3; A7-B5-C4; A7-B5-C5; A7-B5-C6; A7-B5-C7; A7-B5-C8;

A7-B5-C9; A7-B5-C10; A7-B5-C11; A7-B5-C12; A7-B5-C13; A7-B5-C14;

A7-B5-C15; A7-B5-C16; A7-B5-C17; A7-B5-C18; A7-B5-C19; A7-B5-C20;

A7-B5-C21; A7-B5-C22; A7-B5-C23; A7-B5-C24; A7-B5-C25; A7-B5-C26;

A7-B5-C27; A7-B5-C28; A7-B5-C29; A7-B5-C30; A7-B5-C31; A7-B5-C32;

A7-B5-C33; A7-B5-C34; A7-B5-C35; A7-B5-C36; A7-B5-C37; A7-B5-C38;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -54A7-B5-C39; A7-B5-C40; A7-B5-C41; A7-B5-C42; A7-B5-C43; A7-B5-C44;

A7-B5-C45; A7-B5-C46; A8-B5-Cl; A8-B5-C2; A8-B5-C3; A8-B5-C4;

A8-B5-C5; A8-B5-C6; A8-B5-C7; A8-B5-C8; A8-B5-C9; A8-B5-C10;

A8-B5-C11; A8-B5-C12; A8-B5-C13; A8-B5-C14; A8-B5-C15; A8-B5-C16;

A8-B5-C17; A8-B5-C18; A8-B5-Cl9; A8-B5-C20; A8-B5-C21; A8-B5-C22;

A8-B5-C23; A8-B5-C24; A8-B5-C25; A8-B5-C26; A8-B5-C27; A8-B5-C28;

A8-B5-C29; A8-B5-C30; A8-B5-C31; A8-B5-C32; A8-B5-C33; A8-B5-C34;

A8-B5-C35; A8-B5-C36; A8-B5-C37; A8-B5-C38; A8-B5-C39; A8-B5-C40;

A8-B5-C41; A8-B5-C42; A8-B5-C43; A8-B5-C44; A8-B5-C45; A8-B5-C46;

A9-B5-Cl; A9-B5-C2; A9-B5-C3; A9-B5-C4; A9-B5-C5; A9-B5-C6;

A9-B5-C7; A9-B5-C8; A9-B5-C9; A9-B5-C10; A9-B5-Cll; A9-B5-C12;

A9-B5-C13; A9-B5-C14; A9-B5-C15; A9-B5-C16; A9-B5-C17; A9-B5-C18;

A9-B5-C19; A9-B5-C20; A9-B5-C21; A9-B5-C22; A9-B5-C23; A9-B5-C24;

A9-B5-C25; A9-B5-C26; A9-B5-C27; A9-B5-C28; A9-B5-C29; A9-B5-C30;

A9-B5-C31; A9-B5-C32; A9-B5-C33; A9-B5-C34; A9-B5-C35; A9-B5-C36;

A9-B5-C37; A9-B5-C38; A9-B5-C39; A9-B5-C40; A9-B5-C41; A9-B5-C42;

A9-B5-C43; A9-B5-C44; A9-B5-C45; A9-B5-C46; A10-B5-Cl; A10-B5-C2;

A10-B5-C3; A10-B5-C4; A10-B5-C5; A10-B5-C6; A10-B5-C7; A10-B5-C8;

A10-B5-C9; A10-B5-C10; A10-B5-C11; A10-B5-C12; A10-B5-C13; A10-B5-C14;

A10-B5-C15; A10-B5-C16; A10-B5-C17; A10-B5-C18; A10-B5-C19; A10-B5-C20;

A10-B5-C21; A10-B5-C22; A10-B5-C23; A10-B5-C24; A10-B5-C25; A10-B5-C26;

A10-B5-C27; A10-B5-C28; A10-B5-C29; A10-B5-C30; A10-B5-C31; A10-B5-C32;

A10-B5-C33; A10-B5-C34; A10-B5-C35; A10-B5-C36; A10-B5-C37; A10-B5-C38;

A10-B5-C39; A10-B5-C40; A10-B5-C41; A10-B5-C42; A10-B5-C43; A10-B5-C44;

A10-B5-C45; A10-B5-C46; All-B5-C1; All-B5-C2; All-B5-C3; All-B5-C4;

All-B5-C5; All-B5-C6; All-B5-C7; All-B5-C8; All-B5-C9; All-B5-C10;

All-B5-C11; All-B5-C12; All-B5-C13; All-B5-C14; All-B5-C15; All-B5-C16;

All-B5-C17; All-B5-C18; All-B5-C19; All-B5-C20; All-B5-C21; All-B5-C22;

All-B5-C23; All-B5-C24; All-B5-C25; All-B5-C26; All-B5-C27; All-B5-C28;

All-B5-C29; All-B5-C30; All-B5-C31; All-B5-C32; All-B5-C33; All-B5-C34;

All-B5-C35; All-B5-C36; All-B5-C37; All-B5-C38; All-B5-C39; All-B5-C40;

All-B5-C41; All-B5-C42; All-B5-C43; All-B5-C44; All-B5-C45; All-B5-C46;

A12-B5-C1; A12-B5-C2; A12-B5-C3; A12-B5-C4; A12-B5-C5; A12-B5-C6;

A12-B5-C7; A12-B5-C8; A12-B5-C9; A12-B5-C10; A12-B5-Cll; A12-B5-C12;

A12-B5-C13; A12-B5-C14; A12-B5-C15; A12-B5-C16; A12-B5-C17; A12-B5-C18;

A12-B5-C19; A12-B5-C20; A12-B5-C21; A12-B5-C22; A12-B5-C23; A12-B5-C24;

A12-B5-C25; A12-B5-C26; A12-B5-C27; A12-B5-C28; A12-B5-C29; A12-B5-C30;

A12-B5-C31; A12-B5-C32; A12-B5-C33; A12-B5-C34; A12-B5-C35; A12-B5-C36;

A12-B5-C37; A12-B5-C38; A12-B5-C39; A12-B5-C40; A12-B5-C41; A12-B5-C42;

A12-B5-C43; A12-B5-C44; A12-B5-C45; A12-B5-C46; A13-B5-C1; A13-B5-C2;

A13-B5-C3; A13-B5-C4; A13-B5-C5; A13-B5-C6; A13-B5-C7; A13-B5-C8;

A13-B5-C9; A13-B5-C10; A13-B5-Cl1; A13-B5-C12; A13-B5-C13; A13-B5-C14;

A13-B5-C15; A13-B5-C16; A13-B5-C17; A13-B5-C18; A13-B5-C19; A13-B5-C20;

A13-B5-C21; A13-B5-C22; A13-B5-C23; A13-B5-C24; A13-B5-C25; A13-B5-C26;

A13-B5-C27; A13-B5-C28; A13-B5-C29; A13-B5-C30; A13-B5-C31; A13-B5-C32;

A13-B5-C33; A13-B5-C34; A13-B5-C35; A13-B5-C36; A13-B5-C37; A13-B5-C38;

A13-B5-C39; A13-B5-C40; A13-B5-C41; A13-B5-C42; A13-B5-C43; A13-B5-C44;

A13-B5-C45; A13-B5-C46; A14-B5-Cl; A14-B5-C2; A14-B5-C3; A14-B5-C4;

A14-B5-C5; A14-B5-C6; A14-B5-C7; A14-B5-C8; A14-B5-C9; A14-B5-C10;

A14-B5-C11; A14-B5-C12; A14-B5-C13; A14-B5-C14; A14-B5-C15; A14-B5-C16;

A14-B5-Cl7; A14-B5-C18; A14-B5-C19; A14-B5-C20; A14-B5-C21; A14-B5-C22;

A14-B5-C23; A14-B5-C24; A14-B5-C25; A14-B5-C26; A14-B5-C27; A14-B5-C28;

A14-B5-C29; A14-B5-C30; A14-B5-C31; A14-B5-C32; A14-B5-C33; A14-B5-C34;

A14-B5-C35; A14-B5-C36; A14-B5-C37; A14-B5-C38; A14-B5-C39; A14-B5-C40;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -55A14-B5-C41; A14-B5-C42; A14-B5-C43; A14-B5-C44; A14-B5-C45; A14-B5-C46;

A15-B5-C1; A15-B5-C2; A15-B5-C3; A15-B5-C4; A15-B5-C5; A15-B5-C6;

A15-B5-C7; A15-B5-C8; A15-B5-C9; A15-B5-C10; A15-B5-C11; A15-B5-C12;

A15-B5-C13; A15-B5-C14; A15-B5-C15; A15-B5-C16; A15-B5-C17; A15-B5-C18;

A15-B5-C19; A15-B5-C20; A15-B5-C21; A15-B5-C22; A15-B5-C23; A15-B5-C24;

A15-B5-C25; A15-B5-C26; A15-B5-C27; A15-B5-C28; A15-B5-C29; A15-B5-C30;

A15-B5-C31; A15-B5-C32; A15-B5-C33; A15-B5-C34; A15-B5-C35; A15-B5-C36;

A15-B5-C37; A15-B5-C38; A15-B5-C39; A15-B5-C40; A15-B5-C41; A15-B5-C42;

A15-B5-C43; A15-B5-C44; A15-B5-C45; A15-B5-C46; A16-B5-C1; A16-B5-C2;

A16-B5-C3; A16-B5-C4; A16-B5-C5; A16-B5-C6; A16-B5-C7; A16-B5-C8;

A16-B5-C9; A16-B5-C10; A16-B5-C11; A16-B5-C12; A16-B5-C13; A16-B5-C14;

A16-B5-C15; A16-B5-C16; A16-B5-C17; A16-B5-C18; A16-B5-C19; A16-B5-C20;

A16-B5-C21; A16-B5-C22; A16-B5-C23; A16-B5-C24; A16-B5-C25; A16-B5-C26;

A16-B5-C27; A16-B5-C28; A16-B5-C29; A16-B5-C30; A16-B5-C31; A16-B5-C32;

A16-B5-C33; A16-B5-C34; A16-B5-C35; A16-B5-C36; A16-B5-C37; A16-B5-C38;

A16-B5-C39; A16-B5-C40; A16-B5-C41; A16-B5-C42; A16-B5-C43; A16-B5-C44;

A16-B5-C45; A16-B5-C46; A17-B5-C1; A17-B5-C2; A17-B5-C3; A17-B5-C4;

A17-B5-C5; A17-B5-C6; A17-B5-C7; A17-B5-C8; A17-B5-C9; A17-B5-C10;

A17-B5-C11; A17-B5-C12; A17-B5-C13; A17-B5-C14; A17-B5-C15; A17-B5-C16;

A17-B5-C17; A17-B5-C18; A17-B5-C19; A17-B5-C20; A17-B5-C21; A17-B5-C22;

A17-B5-C23; A17-B5-C24; A17-B5-C25; A17-B5-C26; A17-B5-C27; A17-B5-C28;

A17-B5-C29; A17-B5-C30; A17-B5-C31; A17-B5-C32; A17-B5-C33; A17-B5-C34;

A17-B5-C35; A17-B5-C36; A17-B5-C37; A17-B5-C38; A17-B5-C39; A17-B5-C40;

A17-B5-C41; A17-B5-C42; A17-B5-C43; A17-B5-C44; A17-B5-C45; A17-B5-C46;

A18-B5-Cl; A18-B5-C2; A18-B5-C3; A18-B5-C4; A18-B5-C5; A18-B5-C6;

A18-B5-C7; A18-B5-C8; A18-B5-C9; A18-B5-C10; A18-B5-C11; A18-B5-C12;

A18-B5-C13; A18-B5-C14; A18-B5-C15; A18-B5-C16; A18-B5-C17; A18-B5-C18;

A18-B5-C19; A18-B5-C20; A18-B5-C21; A18-B5-C22; A18-B5-C23; A18-B5-C24;

A18-B5-C25; A18-B5-C26; A18-B5-C27; A18-B5-C28; A18-B5-C29; A18-B5-C30;

A18-B5-C31; A18-B5-C32; A18-B5-C33; A18-B5-C34; A18-B5-C35; A18-B5-C36;

A18-B5-C37; A18-B5-C38; A18-B5-C39; A18-B5-C40; A18-B5-C41; A18-B5-C42;

A18-B5-C43; A18-B5-C44; A18-B5-C45; A18-B5-C46; A19-B5-C1; A19-B5-C2;

A19-B5-C3; A19-B5-C4; A19-B5-C5; A19-B5-C6; A19-B5-C7; A19-B5-C8;

A19-B5-C9; A19-B5-C10; A19-B5-C11; A19-B5-C12; A19-B5-C13; A19-B5-C14;

A19-B5-C15; A19-B5-C16; A19-B5-C17; A19-B5-C18; A19-B5-C19; A19-B5-C20;

A19-B5-C21; A19-B5-C22; A19-B5-C23; A19-B5-C24; A19-B5-C25; A19-B5-C26;

A19-B5-C27; A19-B5-C28; A19-B5-C29; A19-B5-C30; A19-B5-C31; A19-B5-C32;

A19-B5-C33; A19-B5-C34; A19-B5-C35; A19-B5-C36; A19-B5-C37; A19-B5-C38;

A19-B5-C39; A19-B5-C40; A19-B5-C41; A19-B5-C42; A19-B5-C43; A19-B5-C44;

A19-B5-C45; A19-B5-C46; A20-B5-Cl; A20-B5-C2; A20-B5-C3; A20-B5-C4;

A20-B5-C5; A20-B5-C6; A20-B5-C7; A20-B5-C8; A20-B5-C9; A20-B5-C10;

A20-B5-C11; A20-B5-C12; A20-B5-C13; A20-B5-C14; A20-B5-C15; A20-B5-C16;

A20-B5-C17; A20-B5-C18; A20-B5-C19; A20-B5-C20; A20-B5-C21; A20-B5-C22;

A20-B5-C23; A20-B5-C24; A20-B5-C25; A20-B5-C26; A20-B5-C27; A20-B5-C28;

A20-B5-C29; A20-B5-C30; A20-B5-C31; A20-B5-C32; A20-B5-C33; A20-B5-C34;

A20-B5-C35; 'A20-B5-C36; A20-B5-C37; A20-B5-C38; A20-B5-C39; A20-B5-C40;

A20-B5-C41; A20-B5-C42; A20-B5-C43; A20-B5-C44; A20-B5-C45; A20-B5-C46;

A21-B5-C1; A21-B5-C2; A21-B5-C3; A21-B5-C4; A21-B5-C5; A21-B5-C6;

A21-B5-C7; A21-B5-C8; A21-B5-C9; A21-B5-C10; A21-B5-Cll; A21-B5-C12;

A21-B5-C13; A21-B5-C14; A21-B5-C15; A21-B5-C16; A21-B5-C17; A21-B5-C18;

A21-B5-C19; A21-B5-C20; A21-B5-C21; A21-B5-C22; A21-B5-C23; A21-B5-C24;

A21-B5-C25; A21-B5-C26; A21-B5-C27; A21-B5-C28; A21-B5-C29; A21-B5-C30;

A21-B5-C31; A21-B5-C32; A21-B5-C33; A21-B5-C34; A21-B5-C35; A21-B5-C36;

A21-B5-C37; A21-B5-C38; A21-B5-C39; A21-B5-C40; A21-B5-C41; A21-B5-C42;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -56A21-B5-C43; A21-B5-C44; A21-B5-C45; A21-B5-C46; A22-B5-C1; A22-B5-C2;

A22-B5-C3; A22-B5-C4; A22-B5-C5; A22-B5-C6; A22-B5-C7; A22-B5-C8;

A22-B5-C9; A22-B5-C10; A22-B5-C11; A22-B5-C12; A22-B5-C13; A22-B5-C14;

A22-B5-C15; A22-B5-C16; A22-B5-C17; A22-B5-C18; A22-B5-C19; A22-B5-C20;

A22-B5-C21; A22-B5-C22; A22-B5-C23; A22-B5-C24; A22-B5-C25; A22-B5-C26;

A22-B5-C27; A22-B5-C28; A22-B5-C29; A22-B5-C30; A22-B5-C31; A22-B5-C32;

A22-B5-C33; A22-B5-C34; A22-B5-C35; A22-B5-C36; A22-B5-C37; A22-B5-C38;

A22-B5-C39; A22-B5-C40; A22-B5-C41; A22-B5-C42; A22-B5-C43; A22-B5-C44;

A22-B5-C45; A22-B5-C46; A23-B5-C1; A23-B5-C2; A23-B5-C3; A23-B5-C4;

A23-B5-C5; A23-B5-C6; A23-B5-C7; A23-B5-C8; A23-B5-C9; A23-B5-C10;

A23-B5-C11; A23-B5-C12; A23-B5-C13; A23-B5-C14; A23-B5-C15; A23-B5-C16;

A23-B5-C17; A23-B5-C18; A23-B5-C19; A23-B5-C20; A23-B5-C21; A23-B5-C22;

A23-B5-C23; A23-B5-C24; A23-B5-C25; A23-B5-C26; A23-B5-C27; A23-B5-C28;

A23-B5-C29; A23-B5-C30; A23-B5-C31; A23-B5-C32; A23-B5-C33; A23-B5-C34;

A23-B5-C35; A23-B5-C36; A23-B5-C37; A23-B5-C38; A23-B5-C39; A23-B5-C40;

A23-B5-C41; A23-B5-C42; A23-B5-C43; A23-B5-C44; A23-B5-C45; A23-B5-C46;

A24-B5-C1; A24-B5-C2; A24-B5-C3; A24-B5-C4; A24-B5-C5; A24-B5-C6;

A24-B5-C7; A24-B5-C8; A24-B5-C9; A24-B5-C10; A24-B5-C11; A24-B5-C12;

A24-B5-C13; A24-B5-C14; A24-B5-C15; A24-B5-C16; A24-B5-C17; A24-B5-C18;

A24-B5-C19; A24-B5-C20; A24-B5-C21; A24-B5-C22; A24-B5-C23; A24-B5-C24;

A24-B5-C25; A24-B5-C26; A24-B5-C27; A24-B5-C28; A24-B5-C29; A24-B5-C30;

A24-B5-C31; A24-B5-C32; A24-B5-C33; A24-B5-C34; A24-B5-C35; A24-B5-C36;

A24-B5-C37; A24-B5-C38; A24-B5-C39; A24-B5-C40; A24-B5-C41; A24-B5-C42;

A24-B5-C43; A24-B5-C44; A24-B5-C45; A24-B5-C46; A25-B5-C1; A25-B5-C2;

A25-B5-C3; A25-B5-C4; A25-B5-C5; A25-B5-C6; A25-B5-C7; A25-B5-C8;

A25-B5-C9; A25-B5-C10; A25-B5-C11; A25-B5-C12; A25-B5-C13; A25-B5-C14;

A25-B5-C15; A25-B5-C16; A25-B5-C17; A25-B5-C18; A25-B5-C19; A25-B5-C20;

A25-B5-C21; A25-B5-C22; A25-B5-C23; A25-B5-C24; A25-B5-C25; A25-B5-C26;

A25-B5-C27; A25-B5-C28; A25-B5-C29; A25-B5-C30; A25-B5-C31; A25-B5-C32;

A25-B5-C33; A25-B5-C34; A25-B5-C35; A25-B5-C36; A25-B5-C37; A25-B5-C38;

A25-B5-C39; A25-B5-C40; A25-B5-C41; A25-B5-C42; A25-B5-C43; A25-B5-C44;

A25-B5-C45; A25-B5-C46; A26-B5-C1; A26-B5-C2; A26-B5-C3; A26-B5-C4;

A26-B5-C5; A26-B5-C6; A26-B5-C7; A26-B5-C8; A26-B5-C9; A26-B5-C10;

A26-B5-C11; A26-B5-C12; A26-B5-C13; A26-B5-C14; A26-B5-C15; A26-B5-C16;

A26-B5-C17; A26-B5-C18; A26-B5-C19; A26-B5-C20; A26-B5-C21; A26-B5-C22;

A26-B5-C23; A26-B5-C24; A26-B5-C25; A26-B5-C26; A26-B5-C27; A26-B5-C28;

A26-B5-C29; A26-B5-C30; A26-B5-C31; A26-B5-C32; A26-B5-C33; A26-B5-C34;

A26-B5-C35; A26-B5-C36; A26-B5-C37; A26-B5-C38; A26-B5-C39; A26-B5-C40;

A26-B5-C41; A26-B5-C42; A26-B5-C43; A26-B5-C44; A26-B5-C45; A26-B5-C46;

A27-B5-C1; A27-B5-C2; A27-B5-C3; A27-B5-C4; A27-B5-C5; A27-B5-C6;

A27-B5-C7; A27-B5-C8; A27-B5-C9; A27-B5-C10; A27-B5-C11; A27-B5-C12;

A27-B5-C13; A27-B5-C14; A27-B5-C15; A27-B5-C16; A27-B5-C17; A27-B5-C18;

A27-B5-C19; A27-B5-C20; A27-B5-C21; A27-B5-C22; A27-B5-C23; A27-B5-C24;

A27-B5-C25; A27-B5-C26; A27-B5-C27; A27-B5-C28; A27-B5-C29; A27-B5-C30;

A27-B5-C31; A27-B5-C32; A27-B5-C33; A27-B5-C34; A27-B5-C35; A27-B5-C36;

A27-B5-C37; A27-B5-C38; A27-B5-C39; A27-B5-C40; A27-B5-C41; A27-B5-C42;

A27-B5-C43; A27-B5-C44; A27-B5-C45; A27-B5-C46; A28-B5-C1; A28-B5-C2;

A28-B5-C3; A28-B5-C4; A28-B5-C5; A28-B5-C6; A28-B5-C7; A28-B5-C8;

A28-B5-C9; A28-B5-C10; A28-B5-C11; A28-B5-C12; A28-B5-C13; A28-B5-C14;

A28-B5-C15; A28-B5-C16; A28-B5-C17; A28-B5-C18; A28-B5-C19; A28-B5-C20;

A28-B5-C21; A28-B5-C22; A28-B5-C23; A28-B5-C24; A28-B5-C25; A28-B5-C26;

A28-B5-C27; A28-B5-C28; A28-B5-C29; A28-B5-C30; A28-B5-C31; A28-B5-C32;

A28-B5-C33; A28-B5-C34; A28-B5-C35; A28-B5-C36; A28-B5-C37; A28435-C38;

A28-B5-C39; A28-B5-C40; A28-B5-C41; A28-B5-C42; A28-B5-C43; A28-B5-C44;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -57A28-B5-C45; A28-B5-C46; Al-B6-C1; Al-B6-C2; Al-B6-C3; Al-B6-C4;

Al-B6-C5; Al-B6-C6; Al-B6-C7; Al-B6-C8; Al-B6-C9; Al-B6-C10;

Al-B6-C11; Al-B6-C12; Al-B6-C13; Al-B6-C14; Al-B6-C15; Al-B6-C16;

Al-B6-C17; Al-B6-C18; Al-B6-C19; Al-B6-C20; Al-B6-C21; Al-B6-C22;

Al-B6-C23; Al-B6-C24;' Al-B6-C25; Al-B6-C26; Al-B6-C27; Al-B6-C28;

Al-B6-C29; Al-B6-C30; Al-B6-C31; Al-B6-C32; Al-B6-C33; Al-B6-C34;

Al-B6-C35; Al-B6-C36; Al-B6-C37; Al-B6-C38; Al-B6-C39; Al-B6-C40;

Al-B6-C41; Al-B6-C42; Al-B6-C43; Al-B6-C44; Al-B6-C45; Al-B6-C46;

A2-B6-Cl; A2-B6-C2; A2-B6-C3; A2-B6-C4; A2-B6-C5; A2-B6-C6;

A2-B6-C7; A2-B6-C8; A2-B6-C9; A2-B6-C10; A2-B6-C11; A2-B6-C12;

A2-B6-C13; A2-B6-C14; A2-B6-C15; A2-B6-C16; A2-B6-C17; A2-B6-C18;

A2-B6-C19; A2-B6-C20; A2-B6-C21; A2-B6-C22; A2-B6-C23; A2-B6-C24;

A2-B6-C25; A2-B6-C26; A2-B6-C27; A2-B6-C28; A2-B6-C29; A2-B6-C30;

A2-B6-C31; A2-B6-C32; A2-B6-C33; A2-B6-C34; A2-B6-C35; A2-B6-C36;

A2-B6-C37; A2-B6-C38; A2-B6-C39; A2-B6-C40; A2-B6-C41; A2-B6-C42;

A2-B6-C43; A2-B6-C44; A2-B6-C45; A2-B6-C46; A3-B6-C1; A3-B6-C2;

A3-B6-C3; A3-B6-C4; A3-B6-C5; A3-B6-C6; A3-B6-C7; A3-B6-C8;

A3-B6-C9; A3-B6-C10; A3-B6-C11; A3-B6-C12; A3-B6-C13; A3-B6-C14;

A3-B6-C15; A3-B6-C16; A3-B6-C17; A3-B6-C18; A3-B6-C19; A3-B6-C20;

A3-B6-C21; A3-B6-C22; A3-B6-C23; A3-B6-C24; A3-B6-C25; A3-B6-C26;

A3-B6-C27; A3-B6-C28; A3-B6-C29; A3-B6-C30; A3-B6-C31; A3-B6-C32;

A3-B6-C33; A3-B6-C34; A3-B6-C35; A3-B6-C36; A3-B6-C37; A3-B6-C38;

A3-B6-C39; A3-B6-C40; A3-B6-C41; A3-B6-C42; A3-B6-C43; A3-B6-C44;

A3-B6-C45; A3-B6-C46; A4-B6-C1; A4-B6-C2; A4-B6-C3; A4-B6-C4;

A4-B6-C5; A4-B6-C6; A4-B6-C7; A4-B6-C8; A4-B6-C9; A4-B6-C10;

A4-B6-Cll; A4-B6-C12; A4-B6-C13; A4-B6-C14; A4-B6-C15; A4-B6-C16;

A4-B6-C17; A4-B6-C18; A4-B6-C19; A4-B6-C20; A4-B6-C21; A4-B6-C22;

A4-B6-C23; A4-B6-C24; A4-B6-C25; A4-B6-C26; A4-B6-C27; A4-B6-C28;

A4-B6-C29; A4-B6-C30; A4-B6-C31; A4-B6-C32; A4-B6-C33; A4-B6-C34;

A4-B6-C35; A4-B6-C36; A4-B6-C37; A4-B6-C38; A4-B6-C39; A4-B6-C40;

A4-B6-C41; A4-B6-C42; A4-B6-C43; A4-B6-C44; A4-B6-C45; A4-B6-C46;

A5-B6-C1; A5-B6-C2; A5-B6-C3; A5-B6-C4; A5-B6-C5; A5-B6-C6;

A5-B6-C7; A5-B6-C8; A5-B6-C9; A5-B6-C10; A5-B6-C11; A5-B6-C12;

A5-B6-C13; A5-B6-C14; A5-B6-C15; A5-B6-C16; A5-B6-C17; A5-B6-C18;

A5-B6-C19; A5-B6-C20; A5-B6-C21; A5-B6-C22; A5-B6-C23; A5-B6-C24;

A5-B6-C25; A5-B6-C26; A5-B6-C27; A5-B6-C28; A5-B6-C29; A5-B6-C30;

A5-B6-C31; A5-B6-C32; A5-B6-C33; A5-B6-C34; A5-B6-C35; A5-B6-C36;

A5-B6-C37; A5-B6-C38; A5-B6-C39; A5-B6-C40; A5-B6-C41; A5-B6-C42;

A5-B6-C43; A5-B6-C44; A5-B6-C45; A5-B6-C46; A6-B6-C1; A6-B6-C2;

A6-B6-C3; A6-B6-C4; A6-B6-C5; A6-B6-C6; A6-B6-C7; A6-B6-C8;

A6-B6-C9; A6-B6-C10; A6-B6-C11; A6-B6-C12; A6-B6-C13; A6-B6-C14;

A6-B6-C15; A6-B6-C16; A6-B6-C17; A6-B6-C18; A6-B6-C19; A6-B6-C20;

A6-B6-C21; A6-B6-C22; A6-B6-C23; A6-B6-C24; A6-B6-C25; A6-B6-C26;

A6-B6-C27; A6-B6-C28; A6-B6-C29; A6-B6-C30; A6-B6-C31; A6-B6-C32;

A6-B6-C33; A6-B6-C34; A6-B6-C35; A6-B6-C36; A6-B6-C37; A6-B6-C38;

A6-B6-C39; A6-B6-C40; A6-B6-C41; A6-B6-C42; A6-B6-C43; A6-B6-C44;

A6-B6-C45; A6-B6-C46; A7-B6-C1; A7-B6-C2; A7-B6-C3; A7-B6-C4;

A7-B6-C5; A7-B6-C6; A7-B6-C7; A7-B6-C8; A7-B6-C9; A7-B6-C10;

A7-B6-C11; A7-B6-C12; A7-B6-C13; A7-B6-C14; A7-B6-C15; A7-B6-C16;

A7-B6-C17; A7-B6-C18; A7-B6-C19; A7-B6-C20; A7-B6-C21; A7-B6-C22;

A7-B6-C23; A7-B6-C24; A7-B6-C25; A7-B6-C26; A7-B6-C27; A7-B6-C28;

A7-B6-C29; A7-B6-C30; A7-B6-C31; A7-B6-C32; A7-B6-C33; A7-B6-C34;

A7-B6-C35; A7-B6-C36; A7-B6-C37; A7-B6-C38; A7-B6-C39; A7-B6-C40;

A7-B6-C41; A7-B6-C42; A7-B6-C43; A7-B6-C44; A7-B6-C45; A7-B6-C46;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -58A8-B6-Cl; A8-B6-C2; A8-B6-C3; A8-B6-C4; A8-B6-C5; A8-B6-C6;

A8-B6-C7; A8-B6-C8; A8-B6-C9; A8-B6-C10; A8-B6-C1l; A8-B6-C12;

A8-B6-C13; A8-B6-C14; A8-B6-C15; A8-B6-C16; A8-B6-C17; A8-B6-C18;

A8-B6-C19; A8-B6-C20; A8-B6-C21; A8-B6-C22; A8-B6-C23; A8-B6-C24;

A8-B6-C25; A8-B6-C26; A8-B6-C27; A8-B6-C28; A8-B6-C29; A8-B6-C30;

A8-B6-C31; A8-B6-C32; A8-B6-C33; A8-B6-C34; A8-B6-C35; A8-B6-C36;

A8-B6-C37; A8-B6-C38; A8-B6-C39; A8-B6-C40; A8-B6-C41; A8-B6-C42;

A8-B6-C43; A8-B6-C44; A8-B6-C45; A8-B6-C46; A9-B6-Cl; A9-B6-C2;

A9-B6-C3; A9-B6-C4; A9-B6-C5; A9-B6-C6; A9-B6-C7; A9-B6-C8;

A9-B6-C9; A9-B6-C10; A9-B6-Cll; A9-B6-C12; A9-B6-C13; A9-B6-C14;

A9-B6-C15; A9-B6-C16; A9-B6-C17; A9-B6-C18; A9-B6-C19; A9-B6-C20;

A9-B6-C21; A9-B6-C22; A9-B6-C23; A9-B6-C24; A9-B6-C25; A9-B6-C26;

A9-B6-C27; A9-B6-C28; A9-B6-C29; A9-B6-C30; A9-B6-C31; A9-B6-C32;

A9-B6-C33; A9-B6-C34; A9-B6-C35; A9-B6-C36; A9-B6-C37; A9-B6-C38;

A9-B6-C39; A9-B6-C40; A9-B6-C41; A9-B6-C42; A9-B6-C43; A9-B6-C44;

A9-B6-C45; A9-B6-C46; A10-B6-Cl; A10-B6-C2; A10-B6-C3; A10-B6-C4;

A10-B6-C5; A10-B6-C6; A10-B6-C7; A10-B6-C8; A10-B6-C9; A10-B6-C10;

A10-B6-C11; A10-B6-C12; A10-B6-C13; A10-B6-C14; A10-B6-C15; A10-B6-C16;

A10-B6-C17; A10-B6-C18; A10-B6-C19; A10-B6-C20; A10-B6-C21; A10-B6-C22;

A10-B6-C23; A10-B6-C24; A10-B6-C25; A10-B6-C26; A10-B6-C27; A10-B6-C28;

A10-B6-C29; A10-B6-C30; A10-B6-C31; A10-B6-C32; A10-B6-C33; A10-B6-C34;

A10-B6-C35; A10-B6-C36; A10-B6-C37; A10-B6-C38; A10-B6-C39; A10-B6-C40;

A10-B6-C41; Al0-B6-C42; A10-B6-C43; A10-B6-C44; A10-B6-C45; A10-B6-C46;

All-B6-C1; All-B6-C2; All-B6-C3; All-B6-C4; All-B6-C5; All-B6-C6;

All-B6-C7; All-B6-C8; All-B6-C9; All-B6-C10; All-B6-Cll; All-B6-C12;

All-B6-C13; All-B6-C14; All-B6-C15; All-B6-C16; All-B6-C17; All-B6-C18;

All-B6-C19; Al1-B6-C20; All-B6-C21; All-B6-C22; All-B6-C23; All-B6-C24;

All-B6-C25; All-B6-C26; All-B6-C27; All-B6-C28; All-B6-C29; All-B6-C30;

All-B6-C31; All-B6-C32; All-B6-C33; All-B6-C34; All-B6-C35; All-B6-C36;

All-B6-C37; All-B6-C38; All-B6-C39; All-B6-C40; All-B6-C41; All-B6-C42;

All-B6-C43; All-B6-C44; All-B6-C45; All-B6-C46; A12-B6-C1; A12-B6-C2;

A12-B6-C3; A12-B6-C4; A12-B6-C5; A12-B6-C6; A12-B6-C7; A12-B6-C8;

A12-B6-C9; A12-B6-C10; A12-B6-C11; A12-B6-C12; A12-B6-C13; A12-B6-C14;

A12-B6-C15; A12-B6-C16; A12-B6-C17; A12-B6-C18; A12-B6-C19; A12-B6-C20;

A12-B6-C21; A12-B6-C22; A12-B6-C23; A12-B6-C24; A12-B6-C25; A12-B6-C26;

A12-B6-C27; A12-B6-C28; A12-B6-C29; A12-B6-C30; A12-B6-C31; A12-B6-C32;

A12-B6-C33; A12-B6-C34; A12-B6-C35; A12-B6-C36; A12-B6-C37; A12-B6-C38;

A12-B6-C39; A12-B6-C40; A12-B6-C41; A12-B6-C42; A12-B6-C43; A12-B6-C44;

A12-B6-C45; A12-B6-C46; A13-B6-Cl; A13-B6-C2; A13-B6-C3; A13-B6-C4;

A13-B6-C5; A13-B6-C6; A13-B6-C7; A13-B6-C8; A13-B6-C9; A13-B6-C10;

A13-B6-C11; A13-B6-C12; A13-B6-C13; A13-B6-C14; A13-B6-C15; A13-B6-C16;

A13-B6-C17; A13-B6-C18; A13-B6-C19; A13-B6-C20; A13-B6-C21; A13-B6-C22;

A13-B6-C23; A13-B6-C24; A13-B6-C25; A13-B6-C26; A13-B6-C27; A13-B6-C28;

A13-B6-C29; A13-B6-C30; A13-B6-C31; A13-B6-C32; A13-B6-C33; A13-B6-C34;

A13-B6-C35; A13-B6-C36; A13-B6-C37; A13-B6-C38; A13-B6-C39; A13-B6-C40;

A13-B6-C41; A13-B6-C42; A13-B6-C43; A13-B6-C44; A13-B6-C45; A13-B6-C46;

A14-B6-Cl; A14-B6-C2; A14-B6-C3; A14-B6-C4; A14-B6-C5; A14-B6-C6;

A14-B6-C7; A14-B6-C8; A14-B6-C9; A14-B6-C10; A14-B6-C11; A14-B6-C12;

A14-B6-C13; A14-B6-C14; A14-B6-C15; A14-B6-C16; A14-B6-C17; A14-B6-C18;

A14-B6-C19; A14-B6-C20; A14-B6-C21; A14-B6-C22; A14-B6-C23; A14-B6-C24;

A14-B6-C25; A14-B6-C26; A14-B6-C27; A14-B6-C28; A14-B6-C29; A14-B6-C30;

A14-B6-C31; A14-B6-C32; A14-B6-C33; A14-B6-C34; A14-B6-C35; A14-B6-C36;

A14-B6-C37; A14-B6-C38; A14-B6-C39; A14-B6-C40; A14-B6-C41; A14-B6-C42;

A14-B6-C43; A14-B6-C44; A14-B6-C45; A14-B6-C46; A15-B6-Cl; A15-B6-C2;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -59A15-B6-C3; A15-B6-C4; A15-B6-C5; A15-B6-C6; A15-B6-C7; A15-B6-C8;

A15-B6-C9; A15-B6-C10; A15-B6-C11; A15-B6-C12; A15-B6-C13; A15-B6-C14;

A15-B6-C15; A15-B6-C16; A15-B6-C17; A15-B6-C18; A15-B6-C19; A15-B6-C20;

A15-B6-C21; A15-B6-C22; A15-B6-C23; A15-B6-C24; A15-B6-C25; A15-B6-C26;

A15-B6-C27; A15-B6-C28; A15-B6-C29; A15-B6-C30; A15-B6-C31; A15-B6-C32;

A15-B6-C33; A15-B6-C34; A15-B6-C35; A15-B6-C36; A15-B6-C37; A15-B6-C38;

A15-B6-C39; A15-B6-C40; A15-B6-C41; A15-B6-C42; A15-B6-C43; A15-B6-C44;

A15-B6-C45; A15-B6-C46; A16-B6-C1; A16-B6-C2; A16-B6-C3; A16-B6-C4;

A16-B6-C5; A16-B6-C6; A16-B6-C7; A16-B6-C8; A16-B6-C9; A16-B6-C10;

A16-B6-C11; A16-B6-C12; A16-B6-C13; A16-B6-C14; A16-B6-C15; A16-B6-C16;

A16-B6-C17; A16-B6-C18; A16-B6-C19; A16-B6-C20; A16-B6-C21; A16-B6-C22;

A16-B6-C23; A16-B6-C24; A16-B6-C25; A16-B6-C26; A16-B6-C27; A16-B6-C28;

A16-B6-C29; A16-B6-C30; A16-B6-C31; A16-B6-C32; A16-B6-C33; A16-B6-C34;

A16-B6-C35; A16-B6-C36; A16-B6-C37; A16-B6-C38; A16-B6-C39; A16-B6-C40;

A16-B6-C41; A16-B6-C42; A16-B6-C43; A16-B6-C44; A16-B6-C45; A16-B6-C46;

A17-B6-C1; A17-B6-C2; A17-B6-C3; A17-B6-C4; A17-B6-C5; A17-B6-C6;

A17-B6-C7; A17-B6-C8; A17-B6-C9; A17-B6-C10; A17-B6-Cll; A17-B6-C12;

A17-B6-C13; A17-B6-C14; A17-B6-C15; A17-B6-C16; A17-B6-C17; A17-B6-C18;

A17-B6-C19; A17-B6-C20; A17-B6-C21; A17-B6-C22; A17-B6-C23; A17-B6-C24;

A17-B6-C25; A17-B6-C26; A17-B6-C27; A17-B6-C28; A17-B6-C29; A17-B6-C30;

A17-B6-C31; A17-B6-C32; A17-B6-C33; A17-B6-C34; A17-B6-C35; A17-B6-C36;

A17-B6-C37; A17-B6-C38; A17-B6-C39; A17-B6-C40; A17-B6-C41; A17-B6-C42;

A17-B6-C43; A17-B6-C44; A17-B6-C45; A17-B6-C46; A18-B6-Cl; A18-B6-C2;

A18-B6-C3; A18-B6-C4; A18-B6-C5; A18-B6-C6; A18-B6-C7; A18-B6-C8;

A18-B6-C9; A18-B6-C10; A18-B6-C11; A18-B6-C12; A18-B6-C13; A18-B6-C14;

A18-B6-C15; A18-B6-C16; A18-B6-C17; A18-B6-C18; A18-B6-C19; A18-B6-C20;

A18-B6-C21; A18-B6-C22; A18-B6-C23; A18-B6-C24; A18-B6-C25; A18-B6-C26;

A18-B6-C27; A18-B6-C28; A18-B6-C29; A18-B6-C30; A18-B6-C31; A18-B6-C32;

A18-B6-C33; A18-B6-C34; A18-B6-C35; A18-B6-C36; A18-B6-C37; A18-B6-C38;

A18-B6-C39; A18-B6-C40; A18-B6-C41; A18-B6-C42; A18-B6-C43; A18-B6-C44;

A18-B6-C45; A18-B6-C46; A19-B6-Cl; A19-B6-C2; A19-B6-C3; A19-B6-C4;

A19-B6-C5; A19-B6-C6; A19-B6-C7; A19-B6-C8; A19-B6-C9; A19-B6-C10;

A19-B6-Cll; A19-B6-C12; A19-B6-C13; A19-B6-C14; A19-B6-C15; A19-B6-C16;

A19-B6-C17; A19-B6-C18; A19-B6-C19; A19-B6-C20; A19-B6-C21; A19-B6-C22;

A19-B6-C23; A19-B6-C24; A19-B6-C25; A19-B6-C26; A19-B6-C27; A19-B6-C28;

A19-B6-C29; A19-B6-C30; A19-B6-C31; A19-B6-C32; A19-B6-C33; A19-B6-C34;

A19-B6-C35; A19-B6-C36; A19-B6-C37; A19-B6-C38; A19-B6-C39; A19-B6-C40;

A19-B6-C41; A19-B6-C42; A19-B6-C43; A19-B6-C44; A19-B6-C45; A19-B6-C46;

A20-B6-C1; A20-B6-C2; A20-B6-C3; A20-B6-C4; A20-B6-C5; A20-B6-C6;

A20-B6-C7; A20-B6-C8; A20-B6-C9; A20-B6-C10; A20-B6-C11; A20-B6-C12;

A20-B6-C13; A20-B6-C14; A20-B6-C15; A20-B6-C16; A20-B6-C17; A20-B6-C18;

A20-B6-C19; A20-B6-C20; A20-B6-C21; A20-B6-C22; A20-B6-C23; A20-B6-C24;

A20-B6-C25; A20-B6-C26; A20-B6-C27; A20-B6-C28; A20-B6-C29; A20-B6-C30;

A20-B6-C31; A20-B6-C32; A20-B6-C33; A20-B6-C34; A20-B6-C35; A20-B6-C36;

A20-B6-C37; A20-B6-C38; A20-B6-C39; A20-B6-C40; A20-B6-C41; A20-B6-C42;

A20-B6-C43; A20-B6-C44; A20-B6-C45; A20-B6-C46; A21-B6-C1; A21-B6-C2;

A21-B6-C3; A21-B6-C4; A21-B6-C5; A21-B6-C6; A21-B6-C7; A21-B6-C8;

A21-B6-C9; A21-B6-C10; A21-B6-Cll; A21-B6-C12; A21-B6-C13; A21-B6-C14;

A21-B6-C15; A21-B6-C16; A21-B6-C17; A21-B6-C18; A21-B6-C19; A21-B6-C20;

A21-B6-C21; A21-B6-C22; A21-B6-C23; A21-B6-C24; A21-B6-C25; A21-B6-C26;

A21-B6-C27; A21-B6-C28; A21-B6-C29; A21-B6-C30; A21-B6-C31; A21-B6-C32;

A21-B6-C33; A21-B6-C34; A21-B6-C35; A21-B6-C36; A21-B6-C37; A21-B6-C38;

A21-B6-C39; A21-B6-C40; A21-B6-C41; A21-B6-C42; A21-B6-C43; A21-B6-C44;

A21-B6-C45; A21-B6-C46; A22-B6-C1; A22-B6-C2; A22-B6-C3; A22-B6-C4;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -60A22-B6-C5; A22-B6-C6; A22-B6-C7; A22-B6-C8; A22-B6-C9; A22-B6-C10;

A22-B6-C11; A22-B6-C12; A22-B6-C13; A22-B6-C14; A22-B6-C15; A22-B6-C16;

A22-B6-C17; A22-B6-C18; A22-B6-C19; A22-B6-C20; A22-B6-C21; A22-B6-C22;

A22-B6-C23; A22-B6-C24; A22-B6-C25; A22-B6-C26; A22-B6-C27; A22-B6-C28;

A22-B6-C29; A22-B6-C30; A22-B6-C31; A22-B6-C32; A22-B6-C33; A22-B6-C34;

A22-B6-C35; A22-B6-C36; A22-B6-C37; A22-B6-C38; A22-B6-C39; A22-B6-C40;

A22-B6-C41; A22-B6-C42; A22-B6-C43; A22-B6-C44; A22-B6-C45; A22-B6-C46;

A23-B6-C1; A23-B6-C2; A23-B6-C3; A23-B6-C4; A23-B6-C5; A23-B6-C6;

A23-B6-C7; A23-B6-C8; A23-B6-C9; A23-B6-C10; A23-B6-C11; A23-B6-C12;

A23-B6-C13; A23-B6-C14; A23-B6-C15; A23-B6-C16; A23-B6-C17; A23-B6-C18;

A23-B6-C19; A23-B6-C20; A23-B6-C21; A23-B6-C22; A23-B6-C23; A23-B6-C24;

A23-B6-C25; A23-B6-C26; A23-B6-C27; A23-B6-C28; A23-B6-C29; A23-B6-C30;

A23-B6-C31; A23-B6-C32; A23-B6-C33; A23-B6-C34; A23-B6-C35; A23-B6-C36;

A23-B6-C37; A23-B6-C38; A23-B6-C39; A23-B6-C40; A23-B6-C41; A23-B6-C42;

A23-B6-C43; A23-B6-C44; A23-B6-C45; A23-B6-C46; A24-B6-C1; A24-B6-C2;

A24-B6-C3; A24-B6-C4; A24-B6-C5; A24-B6-C6; A24-B6-C7; A24-B6-C8;

A24-B6-C9; A24-B6-C10; A24-B6-C11; A24-B6-C12; A24-B6-C13; A24-B6-C14;

A24-B6-C15; A24-B6-C16; A24-B6-C17; A24-B6-C18; A24-B6-C19; A24-B6-C20;

A24-B6-C21; A24-B6-C22; A24-B6-C23; A24-B6-C24; A24-B6-C25; A24-B6-C26;

A24-B6-C27; A24-B6-C28; A24-B6-C29; A24-B6-C30; A24-B6-C31; A24-B6-C32;

A24-B6-C33; A24-B6-C34; A24-B6-C35; A24-B6-C36; A24-B6-C37; A24-B6-C38;

A24-B6-C39; A24-B6-C40; A24-B6-C41; A24-B6-C42; A24-B6-C43; A24-B6-C44;

A24-B6-C45; A24-B6-C46; A25-B6-C1; A25-B6-C2; A25-B6-C3; A25-B6-C4;

A25-B6-C5; A25-B6-C6; A25-B6-C7; A25-B6-C8; A25-B6-C9; A25-B6-C10;

A25-B6-C11; A25-B6-C12; A25-B6-C13; A25-B6-C14; A25-B6-C15; A25-B6-C16;

A25-B6-C17; A25-B6-C18; A25-B6-C19; A25-B6-C20; A25-B6-C21; A25-B6-C22;

A25-B6-C23; A25-B6-C24; A25-B6-C25; A25-B6-C26; A25-B6-C27; A25-B6-C28;

A25-B6-C29; A25-B6-C30; A25-B6-C31; A25-B6-C32; A25-B6-C33; A25-B6-C34;

A25-B6-C35; A25-B6-C36; A25-B6-C37; A25-B6-C38; A25-B6-C39; A25-B6-C40;

A25-B6-C41; A25-B6-C42; A25-B6-C43; A25-B6-C44; A25-B6-C45; A25-B6-C46;

A26-B6-C1; A26-B6-C2; A26-B6-C3; A26-B6-C4; A26-B6-C5; A26-B6-C6;

A26-B6-C7; A26-B6-C8; A26-B6-C9; A26-B6-C10; A26-B6-C11; A26-B6-C12;

A26-B6-C13; A26-B6-C14; A26-B6-C15; A26-B6-C16; A26-B6-C17; A26-B6-C18;

A26-B6-C19; A26-B6-C20; A26-B6-C21; A26-B6-C22; A26-B6-C23; A26-B6-C24;

A26-B6-C25; A26-B6-C26; A26-B6-C27; A26-B6-C28; A26-B6-C29; A26-B6-C30;

A26-B6-C31; A26-B6-C32; A26-B6-C33; A26-B6-C34; A26-B6-C35; A26-B6-C36;

A26-B6-C37; A26-B6-C38; A26-B6-C39; A26-B6-C40; A26-B6-C41; A26-B6-C42;

A26-B6-C43; A26-B6-C44; A26-B6-C45; A26-B6-C46; A27-B6-C1; A27-B6-C2;

A27-B6-C3; A27-B6-C4; A27-B6-C5; A27-B6-C6; A27-B6-C7; A27-B6-C8;

A27-B6-C9; A27-B6-C10; A27-B6-C11; A27-B6-C12; A27-B6-C13; A27-B6-C14;

A27-B6-C15; A27-B6-C16; A27-B6-C17; A27-B6-C18; A27-B6-C19; A27-B6-C20;

A27-B6-C21; A27-B6-C22; A27-B6-C23; A27-B6-C24; A27-B6-C25; A27-B6-C26;

A27-B6-C27; A27-B6-C28; A27-B6-C29; A27-B6-C30; A27-B6-C31; A27-B6-C32;

A27-B6-C33; A27-B6-C34; A27-B6-C35; A27-B6-C36; A27-B6-C37; A27-B6-C38;

A27-B6-C39; A27-B6-C40; A27-B6-C41; A27-B6-C42; A27-B6-C43; A27-B6-C44;

A27-B6-C45; A27-B6-C46; A28-B6-Cl; A28-B6-C2; A28-B6-C3; A28-B6-C4;

A28-B6-C5; A28-B6-C6; A28-B6-C7; A28-B6-C8; A28-B6-C9; A28-B6-C10;

A28-B6-Cll; A28-B6-C12; A28-B6-C13; A28-B6-C14; A28-B6-C15; A28-B6-C16;

A28-B6-C17; A28-B6-C18; A28-B6-C19; A28-B6-C20; A28-B6-C21; A28-B6-C22;

A28-B6-C23; A28-B6-C24; A28-B6-C25; A28-B6-C26; A28-B6-C27; A28-B6-C28;

A28-B6-C29; A28-B6-C30; A28-B6-C31; A28-B6-C32; A28-B6-C33; A28-B6-C34;

A28-B6-C35; A28-B6-C36; A28-B6-C37; A28-B6-C38; A28-B6-C39; A28-B6-C40;

A28-B6-C41; A28-B6-C42; A28-B6-C43; A28-B6-C44; A28-B6-C45; A28436-C46;

Al-B7-C1; Al-B7-C2; Al-B7-C3; Al-B7-C4; Al-B7-C5; Al-B7-C6;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -61A1-B7-C7; Al-B7-C8; Al-B7-C9; Al-B7-C10; Al-B7-C11; Al-B7-C12;

Al-B7-C13; Al-B7-C14; Al-B7-C15; Al-B7-C16; Al-B7-C17; Al-B7-C18;

Al-B7-C19; Al-B7-C20; Al-B7-C21; Al-B7-C22; Al-B7-C23; Al-B7-C24;

Al-B7-C25; Al-B7-C26; Al-B7-C27; Al-B7-C28; Al-B7-C29; Al-B7-C30;

Al-B7-C31; Al-B7-C32; Al-B7-C33; Al-B7-C34; Al-B7-C35; Al-B7-C36;

A1-B7-C37; Al-B7-C38; Al-B7-C39; Al-B7-C40; Al-B7-C41; Al-B7-C42;

Al-B7-C43; Al-B7-C44; Al-B7-C45; Al-B7-C46; A2-B7-Cl; A2-B7-C2;

A2-B7-C3; A2-B7-C4; A2-B7-C5; A2-B7-C6; A2-B7-C7; A2-B7-C8;

A2-B7-C9; A2-B7-C10; A2-B7-C11; A2-B7-C12; A2-B7-C13; A2-B7-C14;

A2-B7-C15; A2-B7-C16; A2-B7-C17; A2-B7-C18; A2-B7-C19; A2-B7-C20;

A2-B7-C21; A2-B7-C22; A2-B7-C23; A2-B7-C24; A2-B7-C25; A2-B7-C26;

A2-B7-C27; A2-B7-C28; A2-B7-C29; A2-B7-C30; A2-B7-C31; A2-B7-C32;

A2-B7-C33; A2-B7-C34; A2-B7-C35; A2-B7-C36; A2-B7-C37; A2-B7-C38;

A2-B7-C39; A2-B7-C40; A2-B7-C41; A2-B7-C42; A2-B7-C43; A2-B7-C44;

A2-B7-C45; A2-B7-C46; A3-B7-C1; A3-B7-C2; A3-B7-C3; A3-B7-C4;

A3-B7-C5; A3-B7-C6; A3-B7-C7; A3-B7-C8; A3-B7-C9; A3-B7-C10;

A3-B7-C11; A3-B7-C12; A3-B7-C13; A3-B7-C14; A3-B7-C15; A3-B7-C16;

A3-B7-C17; A3-B7-C18; A3-B7-C19; A3-B7-C20; A3-B7-C21; A3-B7-C22;

A3-B7-C23; A3-B7-C24; A3-B7-C25; A3-B7-C26; A3-B7-C27; A3-B7-C28;

A3-B7-C29; A3-B7-C30; A3-B7-C31; A3-B7-C32; A3-B7-C33; A3-B7-C34;

A3-B7-C35; A3-B7-C36; A3-B7-C37; A3-B7-C38; A3-B7-C39; A3-B7-C40;

A3-B7-C41; A3-B7-C42; A3-B7-C43; A3-B7-C44; A3-B7-C45; A3-B7-C46;

A4-B7-Cl; A4-B7-C2; A4-B7-C3; A4-B7-C4; A4-B7-C5; A4-B7-C6;

A4-B7-C7; A4-B7-C8; A4-B7-C9; A4-B7-C10; A4-B7-C11; A4-B7-C12;

A4-B7-C13; A4-B7-C14; A4-B7-C15; A4-B7-C16; A4-B7-C17; A4-B7-C18;

A4-B7-C19; A4-B7-C20; A4-B7-C21; A4-B7-C22; A4-B7-C23; A4-B7-C24;

A4-B7-C25; A4-B7-C26; A4-B7-C27; A4-B7-C28; A4-B7-C29; A4-B7-C30;

A4-B7-C31; A4-B7-C32; A4-B7-C33; A4-B7-C34; A4-B7-C35; A4-B7-C36;

A4-B7-C37; A4-B7-C38; A4-B7-C39; A4-B7-C40; A4-B7-C41; A4-B7-C42;

A4-B7-C43; A4-B7-C44; A4-B7-C45; A4-B7-C46; A5-B7-C1; A5-B7-C2;

A5-B7-C3; A5-B7-C4; A5-B7-C5; A5-B7-C6; A5-B7-C7; A5-B7-C8;

A5-B7-C9; A5-B7-C10; A5-B7-C11; A5-B7-C12; A5-B7-C13; A5-B7-C14;

A5-B7-C15; A5-B7-C16; A5-B7-C17; A5-B7-C18; A5-B7-C19; A5-B7-C20;

A5-B7-C21; A5-B7-C22; A5-B7-C23; A5-B7-C24; A5-B7-C25; A5-B7-C26;

A5-B7-C27; A5-B7-C28; A5-B7-C29; A5-B7-C30; A5-B7-C31; A5-B7-C32;

A5-B7-C33; A5-B7-C34; A5-B7-C35; A5-B7-C36; A5-B7-C37; A5-B7-C38;

A5-B7-C39; A5-B7-C40; A5-B7-C41; A5-B7-C42; A5-B7-C43; A5-B7-C44;

A5-B7-C45; A5-B7-C46; A6-B7-C1; A6-B7-C2; A6-B7-C3; A6-B7-C4;

A6-B7-C5; A6-B7-C6; A6-B7-C7; A6-B7-C8; A6-B7-C9; A6-B7-C10;

A6-B7-Cll; A6-B7-C12; A6-B7-C13; A6-B7-C14; A6-B7-C15; A6-B7-C16;

A6-B7-C17; A6-B7-C18; A6-B7-C19; A6-B7-C20; A6-B7-C21; A6-B7-C22;

A6-B7-C23; A6-B7-C24; A6-B7-C25; A6-B7-C26; A6-B7-C27; A6-B7-C28;

A6-B7-C29; A6-B7-C30; A6-B7-C31; A6-B7-C32; A6-B7-C33; A6-B7-C34;

A6-B7-C35; A6-B7-C36; A6-B7-C37; A6-B7-C38; A6-B7-C39; A6-B7-C40;

A6-B7-C41; A6-B7-C42; A6-B7-C43; A6-B7-C44; A6-B7-C45; A6-B7-C46;

A7-B7-C1; A7-B7-C2; A7-B7-C3; A7-B7-C4; A7-B7-C5; A7-B7-C6;

A7-B7-C7; A7-B7-C8; A7-B7-C9; A7-B7-C10; A7-B7-C11; A7-B7-C12;

A7-B7-C13; A7-B7-C14; A7-B7-C15; A7-B7-C16; A7-B7-C17; A7-B7-C18;

A7-B7-C19; A7-B7-C20; A7-B7-C21; A7-B7-C22; A7-B7-C23; A7-B7-C24;

A7-B7-C25; A7-B7-C26; A7-B7-C27; A7-B7-C28; A7-B7-C29; A7-B7-C30;

A7-B7-C31; A7-B7-C32; A7-B7-C33; A7-B7-C34; A7-B7-C35; A7-B7-C36;

A7-B7-C37; A7-B7-C38; A7-B7-C39; A7-B7-C40; A7-B7-C41; A7-B7-C42;

A7-B7-C43; A7-B7-C44; A7-B7-C45; A7-B7-C46; A8-B7-Cl; A8-B7-C2;

A8-B7-C3; A8-B7-C4; A8-B7-C5; A8-B7-C6; A8-B7-C7; A8-B7-C8;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -62A8-B7-C9; A8-B7-C10; A8-B7-Cll; A8-B7-C12; A8-B7-C13; A8-B7-C14;

A8-B7-C15; A8-B7-C16; A8-B7-C17; A8-B7-C18; A8-B7-C19; A8-B7-C20;

A8-B7-C21; A8-B7-C22; A8-B7-C23; A8-B7-C24; A8-B7-C25; A8-B7-C26;

A8-B7-C27; A8-B7-C28; A8-B7-C29; A8-B7-C30; A8-B7-C31; A8-B7-C32;

A8-B7-C33; A8-B7-C34; A8-B7-C35; A8-B7-C36; A8-B7-C37; A8-B7-C38;

A8-B7-C39; A8-B7-C40; A8-B7-C41; A8-B7-C42; A8-B7-C43; A8-B7-C44;

A8-B7-C45; A8-B7-C46; A9-B7-C1; A9-B7-C2; A9-B7-C3; A9-B7-C4;

A9-B7-C5; A9-B7-C6; A9-B7-C7; A9-B7-C8; A9-B7-C9; A9-B7-C10;

A9-B7-C11; A9-B7-C12; A9-B7-C13; A9-B7-C14; A9-B7-C15; A9-B7-C16;

A9-B7-C17; A9-B7-C18; A9-B7-C19; A9-B7-C20; A9-B7-C21; A9-B7-C22;

A9-B7-C23; A9-B7-C24; A9-B7-C25; A9-B7-C26; A9-B7-C27; A9-B7-C28;

A9-B7-C29; A9-B7-C30; A9-B7-C31; A9-B7-C32; A9-B7-C33; A9-B7-C34;

A9-B7-C35; A9-B7-C36; A9-B7-C37; A9-B7-C38; A9-B7-C39; A9-B7-C40;

A9-B7-C41; A9-B7-C42; A9-B7-C43; A9-B7-C44; A9-B7-C45; A9-B7-C46;

AIO-B7-C1; A10-B7-C2; A10-B7-C3; A10-B7-C4; A10-B7-C5; A10-B7-C6;

A1O-B7-C7; A10-B7-C8; A10-B7-C9; A10-B7-ClO; AIO-B7-Cll; A10-B7-C12;

AIO-B7-C13; A10-B7-C14; AlO-B7-C15; A1O-B7-C16; AlO-B7-C17; A10-B7-C18;

A10-B7-C19; AlO-B7-C20; AlO-B7-C21; A10-B7-C22; A10-B7-C23; AlO-B7-C24;

AlO-B7-C25; AlO-B7-C26; A10-B7-C27; A10-B7-C28; A10-B7-C29; A1O-B7-C30;

AlO-B7-C31; AIO-B7-C32; A10-B7-C33; A1O-B7-C34; AlO-B7-C35; A10-B7-C36;

A1O-B7-C37; A10-B7-C38; A1O-B7-C39; A10-B7-C40; AlO-B7-C41; A10-B7-C42;

AIO-B7-C43; AIO-B7-C44; AIO-B7-C45; AIO-B7-C46; All-B7-Cl; All-B7-C2;

All-B7-C3; All-B7-C4; All-B7-C5; All-B7-C6; All-B7-C7; All-B7-C8;

All-B7-C9; All-B7-C10; All-B7-C11; All-B7-C12; All-B7-C13; All-B7-C14;

All-B7-C15; All-B7-C16; All-B7-C17; All-B7-C18; All-B7-C19; All-B7-C20;

All-B7-C21; All-B7-C22; All-B7-C23; All-B7-C24; All-B7-C25; All-B7-C26;

All-B7-C27; All-B7-C28; All-B7-C29; All-B7-C30; All-B7-C31; All-B7-C32;

All-B7-C33; All-B7-C34; All-B7-C35; All-B7-C36; All-B7-C37; All-B7-C38;

All-B7-C39; All-B7-C40; All-B7-C41; All-B7-C42; All-B7-C43; All-B7-C44;

All-B7-C45; All-B7-C46; A12-B7-C1; A12-B7-C2; A12-B7-C3; A12-B7-C4;

A12-B7-C5; A12-B7-C6; A12-B7-C7; A12-B7-C8; A12-B7-C9; A12-B7-C10;

A12-B7-C11; A12-B7-C12; A12-B7-C13; A12-B7-C14; A12-B7-C15; A12-B7-C16;

A12-B7-C17; A12-B7-C18; A12-B7-C19; A12-B7-C20; A12-B7-C21; A12-B7-C22;

A12-B7-C23; A12-B7-C24; A12-B7-C25; A12-B7-C26; A12-B7-C27; A12-B7-C28;

A12-B7-C29; A12-B7-C30; A12-B7-C31; A12-B7-C32; A12-B7-C33; A12-B7-C34;

A12-B7-C35; A12-B7-C36; A12-B7-C37; A12-B7-C38; A12-B7-C39; A12-B7-C40;

A12-B7-C41; A12-B7-C42; A12-B7-C43; A12-B7-C44; A12-B7-C45; A12-B7-C46;

A13-B7-Cl; A13-B7-C2; A13-B7-C3; A13-B7-C4; A13-B7-C5; A13-B7-C6;

A13-B7-C7; A13-B7-C8; A13-B7-C9; A13-B7-CIO; A13-B7-Cll; A13-B7-C12;

A13-B7-C13; A13-B7-C14; A13-B7-C15; A13-B7-C16; A13-B7-Cl7; A13-B7-C18;

A13-B7-C19; A13-B7-C20; A13-B7-C21; A13-B7-C22; A13-B7-C23; A13-B7-C24;

A13-B7-C25; A13-B7-C26; A13-B7-C27; A13-B7-C28; A13-B7-C29; A13-B7-C30;

A13-B7-C31; A13-B7-C32; A13-B7-C33; A13-B7-C34; A13-B7-C35; A13-B7-C36;

A13-B7-C37; A13-B7-C38; A13-B7-C39; A13-B7-C40; A13-B7-C41; A13-B7-C42;

A13-B7-C43; A13-B7-C44; A13-B7-C45; A13-B7-C46; A14-B7-C1; A14-B7-C2;

A14-B7-C3; A14-B7-C4; A14-B7-C5; A14-B7-C6; A14-B7-C7; A14-B7-C8;

A14-B7-C9; Al4-B7-ClO; A14-B7-Cll; A14-B7-C12; A14-B7-C13; A14-B7-C14;

A14-B7-C15; A14-B7-C16; A14-B7-C17; A14-B7-C18; A14-B7-C19; A14-B7-C20;

A14-B7-C21; A14-B7-C22; A14-B7-C23; A14-B7-C24; A14-B7-C25; A14-B7-C26;

A14-B7-C27; A14-B7-C28; A14-B7-C29; A14-B7-C30; A14-B7-C31; A14-B7-C32;

A14-B7-C33; A14-B7-C34; A14-B7-C35; A14-B7-C36; A14-B7-C37; A14-B7-C38;

A14-B7-C39; A14-B7-C40; A14-B7-C41; A14-B7-C42; A14-B7-C43; A14-B7-C44;

A14-B7-C45; A14-B7-C46; A15-B7-C1; A15-B7-C2; A15-B7-C3; A15-B7-C4;

A15-B7-C5; A15-B7-C6; A15-B7-C7; A15-B7-C8; A15-B7-C9; A15-B7-C10;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -63A15-B7-C11; A15-B7-C12; A15-B7-C13; A15-B7-C14; A15-B7-C15; A15-B7-C16;

A15-B7-C17; A15-B7-C18; A15-B7-C19; A15-B7-C20; A15-B7-C21; A15-B7-C22;

A15-B7-C23; A15-B7-C24; A15-B7-C25; A15-B7-C26; A15-B7-C27; A15-B7-C28;

A15-B7-C29; A15-B7-C30; A15-B7-C31; A15-B7-C32; A15-B7-C33; A15-B7-C34;

A15-B7-C35; A15-B7-C36; A15-B7-C37; A15-B7-C38; A15-B7-C39; A15-B7-C40;

A15-B7-C41; A15-B7-C42; A15-B7-C43; A15-B7-C44; A15-B7-C45; A15-B7-C46;

A16-B7-Cl; A16-B7-C2; A16-B7-C3; A16-B7-C4; A16-B7-C5; A16-B7-C6;

A16-B7-C7; A16-B7-C8; A16-B7-C9; A16-B7-C10; A16-B7-C11; A16-B7-C12;

A16-B7-C13; A16-B7-C14; A16-B7-C15; A16-B7-C16; A16-B7-C17; A16-B7-C18;

A16-B7-C19; A16-B7-C20; A16-B7-C21; A16-B7-C22; A16-B7-C23; A16-B7-C24;

A16-B7-C25; A16-B7-C26; A16-B7-C27; A16-B7-C28; A16-B7-C29; A16-B7-C30;

A16-B7-C31; A16-B7-C32; A16-B7-C33; A16-B7-C34; A16-B7-C35; A16-B7-C36;

A16-B7-C37; A16-B7-C38; A16-B7-C39; A16-B7-C40; A16-B7-C41; A16-B7-C42;

A16-B7-C43; A16-B7-C44; A16-B7-C45; A16-B7-C46; A17-B7-C1; A17-B7-C2;

A17-B7-C3; A17-B7-C4; A17-B7-C5; A17-B7-C6; A17-B7-C7; A17-B7-C8;

A17-B7-C9; A17-B7-C10; A17-B7-C11; A17-B7-C12; A17-B7-C13; A17-B7-C14;

A17-B7-C15; A17-B7-C16; A17-B7-C17; A17-B7-C18; A17-B7-C19; A17-B7-C20;

A17-B7-C21; A17-B7-C22; A17-B7-C23; A17-B7-C24; A17-B7-C25; A17-B7-C26;

A17-B7-C27; A17-B7-C28; A17-B7-C29; A17-B7-C30; A17-B7-C31; A17-B7-C32;

A17-B7-C33; A17-B7-C34; A17-B7-C35; A17-B7-C36; A17-B7-C37; A17-B7-C38;

A17-B7-C39; A17-B7-C40; A17-B7-C41; A17-B7-C42; A17-B7-C43; A17-B7-C44;

A17-B7-C45; A17-B7-C46; A18-B7-C1; A18-B7-C2; A18-B7-C3; A18-B7-C4;

A18-B7-C5; A18-B7-C6; A18-B7-C7; A18-B7-C8; A18-B7-C9; A18-B7-C10;

A18-B7-C11; A18-B7-C12; A18-B7-C13; A18-B7-C14; A18-B7-C15; A18-B7-C16;

A18-B7-C17; A18-B7-C18; A18-B7-C19; A18-B7-C20; A18-B7-C21; A18-B7-C22;

A18-B7-C23; A18-B7-C24; A18-B7-C25; A18-B7-C26; A18-B7-C27; A18-B7-C28;

A18-B7-C29; A18-B7-C30; A18-B7-C31; A18-B7-C32; A18-B7-C33; A18-B7-C34;

A18-B7-C35; A18-B7-C36; A18-B7-C37; A18-B7-C38; A18-B7-C39; A18-B7-C40;

A18-B7-C41; A18-B7-C42; A18-B7-C43; A18-B7-C44; A18-B7-C45; A18-B7-C46;

A19-B7-Cl; A19-B7-C2; A19-B7-C3; A19-B7-C4; A19-B7-C5; A19-B7-C6;

A19-B7-C7; A19-B7-C8; A19-B7-C9; A19-B7-C10; A19-B7-C11; A19-B7-C12;

A19-B7-C13; A19-B7-C14; A19-B7-C15; A19-B7-C16; A19-B7-C17; A19-B7-C18;

A19-B7-C19; A19-B7-C20; A19-B7-C21; A19-B7-C22; A19-B7-C23; A19-B7-C24;

A19-B7-C25; A19-B7-C26; A19-B7-C27; A19-B7-C28; A19-B7-C29; A19-B7-C30;

A19-B7-C31; A19-B7-C32; A19-B7-C33; A19-B7-C34; A19-B7-C35; A19-B7-C36;

A19-B7-C37; A19-B7-C38; A19-B7-C39; A19-B7-C40; A19-B7-C41; A19-B7-C42;

A19-B7-C43; A19-B7-C44; A19-B7-C45; A19-B7-C46; A20-B7-C1; A20-B7-C2;

A20-B7-C3; A20-B7-C4; A20-B7-C5; A20-B7-C6; A20-B7-C7; A20-B7-C8;

A20-B7-C9; A20-B7-C10; A20-B7-C11; A20-B7-C12; A20-B7-C13; A20-B7-C14;

A20-B7-C15; A20-B7-C16; A20-B7-C17; A20-B7-C18; A20-B7-C19; A20-B7-C20;

A20-B7-C21; A20-B7-C22; A20-B7-C23; A20-B7-C24; A20-B7-C25; A20-B7-C26;

A20-B7-C27; A20-B7-C28; A20-B7-C29; A20-B7-C30; A20-B7-C31; A20-B7-C32;

A20-B7-C33; A20-B7-C34; A20-B7-C35; A20-B7-C36; A20-B7-C37; A20-B7-C38;

A20-B7-C39; A20-B7-C40; A20-B7-C41; A20-B7-C42; A20-B7-C43; A20-B7-C44;

A20-B7-C45; A20-B7-C46; A21-B7-Cl; A21-B7-C2; A21-B7-C3; A21-B7-C4;

A21-B7-C5; A21-B7-C6; A21-B7-C7; A21-B7-C8; A21-B7-C9; A21-B7-C10;

A21-B7-C11; A21-B7-C12; A21-B7-C13; A21-B7-C14; A21-B7-C15; A21-B7-C16;

A21-B7-C17; A21-B7-C18; A21-B7-C19; A21-B7-C20; A21-B7-C21; A21-B7-C22;

A21-B7-C23; A21-B7-C24; A21-B7-C25; A21-B7-C26; A21-B7-C27; A21-B7-C28;

A21-B7-C29; A21-B7-C30; A21-B7-C31; A21-B7-C32; A21-B7-C33; A21-B7-C34;

A21-B7-C35; A21-B7-C36; A21-B7-C37; A21-B7-C38; A21-B7-C39; A21-B7-C40;

A21-B7-C41; A21-B7-C42; A21-B7-C43; A21-B7-C44; A21-B7-C45; A21-B7-C46;

A22-B7-Cl; A22-B7-C2; A22-B7-C3; A22-B7-C4; A22-B7-C5; A22-B7-C6;

A22-B7-C7; A22-B7-C8; A22-B7-C9; A22-B7-C10; A22-B7-C11; A22-B7-C12;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -64A22-B7-C13; A22-B7-C14; A22-B7-C15; A22-B7-C16; A22-B7-C17; A22-B7-C18;

A22-B7-C19; A22-B7-C20; A22-B7-C21; A22-B7-C22; A22-B7-C23; A22-B7-C24;

A22-B7-C25; A22-B7-C26; A22-B7-C27; A22-B7-C28; A22-B7-C29; A22-B7-C30;

A22-B7-C31; A22-B7-C32; A22-B7-C33; A22-B7-C34; A22-B7-C35; A22-B7-C36;

A22-B7-C37; A22-B7-C38; A22-B7-C39; A22-B7-C40; A22-B7-C41; A22-B7-C42;

A22-B7-C43; A22-B7-C44; A22-B7-C45; A22-B7-C46; A23-B7-C1; A23-B7-C2;

A23-B7-C3; A23-B7-C4; A23-B7-C5; A23-B7-C6; A23-B7-C7; A23-B7-C8;

A23-B7-C9; A23-B7-C10; A23-B7-C11; A23-B7-C12; A23-B7-C13; A23-B7-C14;

A23-B7-C15; A23-B7-C16; A23-B7-C17; A23-B7-C18; A23-B7-C19; A23-B7-C20;

A23-B7-C21; A23-B7-C22; A23-B7-C23; A23-B7-C24; A23-B7-C25; A23-B7-C26;

A23-B7-C27; A23-B7-C28; A23-B7-C29; A23-B7-C30; A23-B7-C31; A23-B7-C32;

A23-B7-C33; A23-B7-C34; A23-B7-C35; A23-B7-C36; A23-B7-C37; A23-B7-C38;

A23-B7-C39; A23-B7-C40; A23-B7-C41; A23-B7-C42; A23-B7-C43; A23-B7-C44;

A23-B7-C45; A23-B7-C46; A24-B7-Cl; A24-B7-C2; A24-B7-C3; A24-B7-C4;

A24-B7-C5; A24-B7-C6; A24-B7-C7; A24-B7-C8; A24-B7-C9; A24-B7-C10;

A24-B7-C11; A24-B7-C12; A24-B7-C13; A24-B7-C14; A24-B7-C15; A24-B7-C16;

A24-B7-C17; A24-B7-C18; A24-B7-C19; A24-B7-C20; A24-B7-C21; A24-B7-C22;

A24-B7-C23; A24-B7-C24; A24-B7-C25; A24-B7-C26; A24-B7-C27; A24-B7-C28;

A24-B7-C29; A24-B7-C30; A24-B7-C31; A24-B7-C32; A24-B7-C33; A24-B7-C34;

A24-B7-C35; A24-B7-C36; A24-B7-C37; A24-B7-C38; A24-B7-C39; A24-B7-C40;

A24-B7-C41; A24-B7-C42; A24-B7-C43; A24-B7-C44; A24-B7-C45; A24-B7-C46;

A25-B7-C1; A25-B7-C2; A25-B7-C3; A25-B7-C4; A25-B7-C5; A25-B7-C6;

A25-B7-C7; A25-B7-C8; A25-B7-C9; A25-B7-C10; A25-B7-C11; A25-B7-C12;

A25-B7-C13; A25-B7-C14; A25-B7-C15; A25-B7-C16; A25-B7-C17; A25-B7-C18;

A25-B7-C19; A25-B7-C20; A25-B7-C21; A25-B7-C22; A25-B7-C23; A25-B7-C24;

A25-B7-C25; A25-B7-C26; A25-B7-C27; A25-B7-C28; A25-B7-C29; A25-B7-C30;

A25-B7-C31; A25-B7-C32; A25-B7-C33; A25-B7-C34; A25-B7-C35; A25-B7-C36;

A25-B7-C37; A25-B7-C38; A25-B7-C39; A25-B7-C40; A25-B7-C41; A25-B7-C42;

A25-B7-C43; A25-B7-C44; A25-B7-C45; A25-B7-C46; A26-B7-C1; A26-B7-C2;

A26-B7-C3; A26-B7-C4; A26-B7-C5; A26-B7-C6; A26-B7-C7; A26-B7-C8;

A26-B7-C9; A26-B7-C10; A26-B7-C11; A26-B7-C12; A26-B7-C13; A26-B7-C14;

A26-B7-C15; A26-B7-C16; A26-B7-C17; A26-B7-C18; A26-B7-C19; A26-B7-C20;

A26-B7-C21; A26-B7-C22; A26-B7-C23; A26-B7-C24; A26-B7-C25; A26-B7-C26;

A26-B7-C27; A26-B7-C28; A26-B7-C29; A26-B7-C30; A26-B7-C31; A26-B7-C32;

A26-B7-C33; A26-B7-C34; A26-B7-C35; A26-B7-C36; A26-B7-C37; A26-B7-C38;

A26-B7-C39; A26-B7-C40; A26-B7-C41; A26-B7-C42; A26-B7-C43; A26-B7-C44;

A26-B7-C45; A26-B7-C46; A27-B7-C1; A27-B7-C2; A27-B7-C3; A27-B7-C4;

A27-B7-C5; A27-B7-C6; A27-B7-C7; A27-B7-C8; A27-B7-C9; A27-B7-C10;

A27-B7-C11; A27-B7-C12; A27-B7-C13; A27-B7-C14; A27-B7-C15; A27-B7-C16;

A27-B7-C17; A27-B7-C18; A27-B7-C19; A27-B7-C20; A27-B7-C21; A27-B7-C22;

A27-B7-C23; A27-B7-C24; A27-B7-C25; A27-B7-C26; A27-B7-C27; A27-B7-C28;

A27-B7-C29; A27-B7-C30; A27-B7-C31; A27-B7-C32; A27-B7-C33; A27-B7-C34;

A27-B7-C35; A27-B7-C36; A27-B7-C37; A27-B7-C38; A27-B7-C39; A27-B7-C40;

A27-B7-C41; A27-B7-C42; A27-B7-C43; A27-B7-C44; A27-B7-C45; A27-B7-C46;

A28-B7-C1; A28-B7-C2; A28-B7-C3; A28-B7-C4; A28-B7-C5; A28-B7-C6;

A28-B7-C7; A28-B7-C8; A28-B7-C9; A28-B7-C10; A28-B7-C11; A28-B7-C12;

A28-B7-C13; A28-B7-C14; A28-B7-C15; A28-B7-C16; A28-B7-C17; A28-B7-C18;

A28-B7-C19; A28-B7-C20; A28-B7-C21; A28-B7-C22; A28-B7-C23; A28-B7-C24;

A28-B7-C25; A28-B7-C26; A28-B7-C27; A28-B7-C28; A28-B7-C29; A28-B7-C30;

A28-B7-C31; A28-B7-C32; A28-B7-C33; A28-B7-C34; A28-B7-C35; A28-B7-C36;

A28-B7-C37; A28-B7-C38; A28-B7-C39; A28-B7-C40; A28-B7-C41; A28-B7-C42;

A28-B7-C43; A28-B7-C44; A28-B7-C45; A28-B7-C46; Al-B8-Cl; Al-B8-C2;

Al-B8-C3; Al-B8-C4; Al-B8-C5; Al-B8-C6; Al-B8-C7; Al-B8-C8;

Al-B8-C9; Al-B8-C10; Al-B8-Cll; A1-B8-C12; Al-B8-C13; Al-BS-C14;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -65A1-B8-C15; Al-B8-C16; Al-B8-C17; Al-B8-C18; Al-B8-C19; Al-B8-C20;

Al-B8-C21; Al-B8-C22; Al-B8-C23; Al-B8-C24; Al-B8-C25; Al-B8-C26;

Al-B8-C27; Al-B8-C28; Al-B8-C29; Al-B8-C30; Al-B8-C31; Al-B8-C32;

Al-B8-C33; Al-B8-C34; Al-B8-C35; Al-B8-C36; Al-B8-C37; Al-B8-C38;

Al-B8-C39; Al-B8-C40; Al-B8-C41; Al-B8-C42; Al-B8-C43; Al-B8-C44;

Al-B8-C45; Al-B8-C46; A2-B8-C1; A2-B8-C2; A2-B8-C3; A2-B8-C4;

A2-B8-C5; A2-B8-C6; A2-B8-C7; A2-B8-C8; A2-B8-C9; A2-B8-C10;

A2-B8-C11; A2-B8-C12; A2-B8-C13; A2-B8-C14; A2-B8-C15; A2-B8-C16;

A2-B8-C17; A2-B8-C18; A2-B8-C19; A2-B8-C20; A2-B8-C21; A2-B8-C22;

A2-B8-C23; A2-B8-C24; A2-B8-C25; A2-B8-C26; A2-B8-C27; A2-B8-C28;

A2-B8-C29; A2-B8-C30; A2-B8-C31; A2-B8-C32; A2-B8-C33; A2-B8-C34;

A2-B8-C35; A2-B8-C36; A2-B8-C37; A2-B8-C38; A2-B8-C39; A2-B8-C40;

A2-B8-C41; A2-B8-C42; A2-B8-C43; A2-B8-C44; A2-B8-C45; A2-B8-C46;

A3-B8-C1; A3-B8-C2; A3-B8-C3; A3-B8-C4; A3-B8-C5; A3-B8-C6;

A3-B8-C7; A3-B8-C8; A3-B8-C9; A3-B8-C10; A3-B8-C11; A3-B8-C12;

A3-B8-C13; A3-B8-C14; A3-B8-C15; A3-B8-C16; A3-B8-C17; A3-B8-C18;

A3-B8-C19; A3-B8-C20; A3-B8-C21; A3-B8-C22; A3-B8-C23; A3-B8-C24;

A3-B8-C25; A3-B8-C26; A3-B8-C27; A3-B8-C28; A3-B8-C29; A3-B8-C30;

A3-B8-C31; A3-B8-C32; A3-B8-C33; A3-B8-C34; A3-B8-C35; A3-B8-C36;

A3-B8-C37; A3-B8-C38; A3-B8-C39; A3-B8-C40; A3-B8-C41; A3-B8-C42;

A3-B8-C43; A3-B8-C44; A3-B8-C45; A3-B8-C46; A4-B8-C1; A4-B8-C2;

A4-B8-C3; A4-B8-C4; A4-B8-C5; A4-B8-C6; A4-B8-C7; A4-B8-C8;

A4-B8-C9; A4-B8-C10; A4-B8-Cll; A4-B8-C12; A4-B8-C13; A4-B8-C14;

A4-B8-C15; A4-B8-C16; A4-B8-C17; A4-B8-C18; A4-B8-C19; A4-B8-C20;

A4-B8-C21; A4-B8-C22; A4-B8-C23; A4-B8-C24; A4-B8-C25; A4-B8-C26;

A4-B8-C27; A4-B8-C28; A4-B8-C29; A4-B8-C30; A4-B8-C31; A4-B8-C32;

A4-B8-C33; A4-B8-C34; A4-B8-C35; A4-B8-C36; A4-B8-C37; A4-B8-C38;

A4-B8-C39; A4-B8-C40; A4-B8-C41; A4-B8-C42; A4-B8-C43; A4-B8-C44;

A4-B8-C45; A4-B8-C46; A5-B8-C1; A5-B8-C2; A5-B8-C3; A5-B8-C4;

A5-B8-C5; A5-B8-C6; A5-B8-C7; A5-B8-C8; A5-B8-C9; A5-B8-C10;

A5-B8-Cll; A5-B8-C12; A5-B8-C13; A5-B8-C14; A5-B8-C15; A5-B8-C16;

A5-B8-C17; A5-B8-C18; A5-B8-C19; A5-B8-C20; A5-B8-C21; A5-B8-C22;

A5-B8-C23; A5-B8-C24; A5-B8-C25; A5-B8-C26; A5-B8-C27; A5-B8-C28;

A5-B8-C29; A5-B8-C30; A5-B8-C31; A5-B8-C32; A5-B8-C33; A5-B8-C34;

A5-B8-C35; A5-B8-C36; A5-B8-C37; A5-B8-C38; A5-B8-C39; A5-B8-C40;

A5-B8-C41; A5-B8-C42; A5-B8-C43; A5-B8-C44; A5-B8-C45; A5-B8-C46;

A6-B8-C1; A6-B8-C2; A6-B8-C3; A6-B8-C4; A6-B8-C5; A6-B8-C6;

A6-B8-C7; A6-B8-C8; A6-B8-C9; A6-B8-C10; A6-B8-C11; A6-B8-C12;

A6-B8-C13;. A6-B8-C14; A6-B8-C15; A6-B8-C16; A6-B8-C17; A6-B8-C18;

A6-B8-C19; A6-B8-C20; A6-B8-C21; A6-B8-C22; A6-B8-C23; A6-B8-C24;

A6-B8-C25; A6-B8-C26; A6-B8-C27; A6-B8-C28; A6-B8-C29; A6-B8-C30;

A6-B8-C31; A6-B8-C32; A6-B8-C33; A6-B8-C34; A6-B8-C35; A6-B8-C36;

A6-B8-C37; A6-B8-C38; A6-B8-C39; A6-B8-C40; A6-B8-C41; A6-B8-C42;

A6-B8-C43; A6-B8-C44; A6-B8-C45; A6-B8-C46; A7-B8-C1; A7-B8-C2;

A7-B8-C3; A7-B8-C4; A7-B8-C5; A7-B8-C6; A7-B8-C7; A7-B8-C8;

A7-B8-C9; A7-B8-C10; A7-B8-C11; A7-B8-C12; A7-B8-C13; A7-B8-C14;

A7-B8-C15; A7-B8-C16; A7-B8-C17; A7-B8-C18; A7-B8-C19; A7-B8-C20;

A7-B8-C21; A7-B8-C22; A7-B8-C23; A7-B8-C24; A7-B8-C25; A7-B8-C26;

A7-B8-C27; A7-B8-C28; A7-B8-C29; A7-B8-C30; A7-B8-C31; A7-B8-C32;

A7-B8-C33; A7-B8-C34; A7-B8-C35; A7-B8-C36; A7-B8-C37; A7-B8-C38;

A7-B8-C39; A7-B8-C40; A7-B8-C41; A7-B8-C42; A7-B8-C43; A7-B8-C44;

A7-B8-C45; A7-B8-C46; A8-B8-C1; A8-B8-C2; A8-B8-C3; A8-B8-C4;

A8-B8-C5; A8-B8-C6; A8-B8-C7; A8-138-C8; A8-B8-C9; A8-B8-C10;

A8-B8-C11; A8-B8-C12; A8-B8-C13; A8-B8-C14; A8-B8-C15; A8-B8-C16;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -66A8-B8-C17; A8-B8-C18; A8-B8-C19; A8-B8-C20; A8-B8-C21; A8-B8-C22;

A8-B8-C23; A8-B8-C24; A8-B8-C25; A8-B8-C26; A8-B8-C27; A8-B8-C28;

A8-B8-C29; A8-B8-C30; A8-B8-C31; A8-B8-C32; A8-B8-C33; A8-B8-C34;

A8-B8-C35; A8-B8-C36; A8-B8-C37; A8-B8-C38; A8-B8-C39; A8-B8-C40;

A8-B8-C41; A8-B8-C42; A8-B8-C43; A8-B8-C44; A8-B8-C45; A8-B8-C46;

A9-B8-Cl; A9-B8-C2; A9-B8-C3; A9-B8-C4; A9-B8-C5; A9-B8-C6;

A9-B8-C7; A9-B8-C8; A9-B8-C9; A9-B8-C10; A9-B8-Cll; A9-B8-C12;

A9-B8-C13; A9-BS-C14; A9-B8-C15; A9-B8-C16; A9-B8-C17; A9-B8-C18;

A9-B8-C19; A9-B8-C20; A9-B8-C21; A9-B8-C22; A9-B8-C23; A9-B8-C24;

A9-B8-C25; A9-B8-C26; A9-B8-C27; A9-B8-C28; A9-B8-C29; A9-B8-C30;

A9-B8-C31; A9-B8-C32; A9-B8-C33; A9-B8-C34; A9-B8-C35; A9-B8-C36;

A9-B8-C37; A9-B8-C38; A9-B8-C39; A9-B8-C40; A9-B8-C41; A9-B8-C42;

A9-B8-C43; A9-B8-C44; A9-B8-C45; A9-B8-C46; A10-B8-Cl; A10-B8-C2;

A10-B8-C3; A10-B8-C4; A10-B8-C5; A10-B8-C6; A10-B8-C7; A10-B8-C8;

A10-B8-C9; A10-B8-C10; A10-B8-Cll; A10-B8-C12; A10-B8-C13; A10-B8-C14;

A10-B8-C15; A10-B8-C16; A10-B8-C17; A10-B8-C18; A10-B8-C19; A10-B8-C20;

A10-B8-C21; A10-B8-C22; A10-B8-C23; A10-B8-C24; A10-B8-C25; A10-B8-C26;

A10-B8-C27; A10-B8-C28; A10-B8-C29; A10-B8-C30; A10-B8-C31; A10-B8-C32;

A10-B8-C33; A10-B8-C34; A10-B8-C35; A10-B8-C36; A10-B8-C37; A10-B8-C38;

A10-B8-C39; A10-B8-C40; A10-B8-C41; A10-B8-C42; A10-B8-C43; A10-B8-C44;

A10-B8-C45; A10-B8-C46; All-B8-C1; All-B8-C2; All-B8-C3; All-B8-C4;

All-B8-C5; All-B8-C6; All-B8-C7; All-B8-C8; All-B8-C9; All-B8-C10;

All-B8-C11; All-B8-C12; All-B8-C13; All-B8-C14; All-B8-C15; All-B8-C16;

All-B8-C17; All-B8-C18; All-B8-C19; All-B8-C20; All-B8-C21; All-B8-C22;

All-B8-C23; All-B8-C24; All-B8-C25; All-B8-C26; All-B8-C27; All-B8-C28;

All-B8-C29; All-B8-C30; All-B8-C31; All-B8-C32; All-B8-C33; All-B8-C34;

All-B8-C35; All-B8-C36; All-B8-C37; All-B8-C38; All-B8-C39; All-B8-C40;

All-B8-C41; All-B8-C42; All-B8-C43; All-B8-C44; All-B8-C45; All-B8-C46;

A12-B8-C1; A12-B8-C2; A12-B8-C3; A12-B8-C4; A12-B8-C5; A12-B8-C6;

A12-B8-C7; A12-B8-C8; A12-B8-C9; A12-B8-C10; A12-B8-Cl1; A12-B8-C12;

A12-B8-C13; A12-B8-C14; A12-B8-C15; A12-B8-C16; A12-B8-C17; A12-B8-C18;

A12-B8-C19; A12-B8-C20; A12-B8-C21; A12-B8-C22; A12-B8-C23; A12-B8-C24;

A12-B8-C25; A12-B8-C26; A12-B8-C27; A12-B8-C28; A12-B8-C29; A12-B8-C30;

A12-B8-C31; A12-B8-C32; A12-B8-C33; A12-B8-C34; A12-B8-C35; A12-B8-C36;

A12-B8-C37; A12-B8-C38; A12-B8-C39; A12-B8-C40; A12-B8-C41; A12-B8-C42;

A12-B8-C43; A12-B8-C44; A12-B8-C45; A12-B8-C46; A13-B8-Cl; A13-B8-C2;

A13-B8-C3; A13-B8-C4; A13-B8-C5; A13-B8-C6; A13-B8-C7; A13-B8-C8;

A13-B8-C9; A13-B8-C10; A13-B8-C11; A13-B8-C12; A13-B8-C13; A13-B8-C14;

A13-B8-C15; A13-B8-C16; A13-B8-C17; A13-B8-C18; A13-B8-C19; A13-B8-C20;

A13-B8-C21; A13-B8-C22; A13-B8-C23; A13-B8-C24; A13-B8-C25; A13-B8-C26;

A13-B8-C27; A13-B8-C28; A13-B8-C29; A13-B8-C30; A13-B8-C31; A13-B8-C32;

A13-B8-C33; A13-B8-C34; A13-B8-C35; A13-B8-C36; A13-B8-C37; A13-B8-C38;

A13-B8-C39; A13-B8-C40; A13-B8-C41; A13-B8-C42; A13-B8-C43; A13-B8-C44;

A13-B8-C45; A13-B8-C46; A14-B8-Cl; A14-B8-C2; A14-B8-C3; A14-B8-C4;

A14-B8-C5; A14-B8-C6; A14-B8-C7; A14-B8-C8; A14-B8-C9; A14-B8-C10;

A14-B8-C11; A14-B8-C12; A14-B8-C13; A14-B8-Cl4; A14-B8-C15; A14-B8-C16;

A14-B8-C17; A14-B8-C18; A14-B8-C19; A14-B8-C20; A14-B8-C21; A14-B8-C22;

A14-B8-C23; A14-B8-C24; A14-B8-C25; A14-B8-C26; A14-B8-C27; A14-B8-C28;

A14-B8-C29; A14-B8-C30; A14-B8-C31; A14-B8-C32; A14-B8-C33; A14-B8-C34;

A14-B8-C35; A14-B8-C36; A14-B8-C37; A14-B8-C38; A14-B8-C39; A14-B8-C40;

A14-B8-C41; A14-B8-C42; A14-B8-C43; A14-B8-C44; A14-B8-C45; A14-B8-C46;

A15-B8-Cl; A15-B8-C2; A15-B8-C3; A15-B8-C4; A15-B8-C5; A15-B8-C6;

A15-B8-C7; A15-B8-C8; A15-B8-C9; A15-B8-ClO; A15-B8-C11; A15-B8-C12;

A15-B8-C13; A15-B8-C14; A15-B8-C15; A15-B8-Cl6; A15-B8-C17; A15-B8-C18;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -67A15-B8-C19; A15-B8-C20; A15-B8-C21; A15-B8-C22; A15-B8-C23; A15-B8-C24;

A15-B8-C25; A15-B8-C26; A15-B8-C27; A15-B8-C28; A15-B8-C29; A15-B8-C30;

A15-B8-C31; A15-B8-C32; A15-B8-C33; A15-B8-C34; A15-B8-C35; A15-B8-C36;

A15-B8-C37; A15-B8-C38; A15-B8-C39; A15-B8-C40; A15-B8-C41; A15-B8-C42;

A15-B8-C43; A15-B8-C44; A15-B8-C45; A15-B8-C46; A16-B8-Cl; A16-B8-C2;

A16-B8-C3; A16-B8-C4; A16-B8-C5; A16-B8-C6; A16-B8-C7; A16-B8-C8;

A16-B8-C9; A16-B8-C10; A16-B8-C11; A16-B8-C12; A16-B8-C13; A16-BS-C14;

A16-B8-C15; A16-B8-C16; A16-B8-C17; A16-BS-C18; A16-B8-C19; A16-B8-C20;

A16-B8-C21; A16-B8-C22; A16-B8-C23; A16-B8-C24; A16-B8-C25; A16-B8-C26;

A16-B8-C27; A16-B8-C28; A16-B8-C29; A16-B8-C30; A16-B8-C31; A16-B8-C32;

A16-B8-C33; A16-B8-C34; A16-B8-C35; A16-B8-C36; A16-B8-C37; A16-B8-C38;

A16-B8-C39; A16-B8-C40; A16-B8-C41; A16-B8-C42; A16-B8-C43; A16-B8-C44;

A16-B8-C45; A16-B8-C46; A17-B8-C1; A17-B8-C2; A17-B8-C3; A17-B8-C4;

A17-B8-C5; A17-B8-C6; A17-B8-C7; A17-B8-C8; A17-B8-C9; A17-B8-C10;

A17-B8-C11; A17-BS-C12; A17-B8-C13; A17-B8-C14; A17-B8-C15; A17-B8-C16;

A17-B8-C17; A17-B8-C18; A17-B8-C19; A17-B8-C20; A17-B8-C21; A17-B8-C22;

A17-B8-C23; A17-B8-C24; A17-B8-C25; A17-B8-C26; A17-B8-C27; A17-B8-C28;

A17-B8-C29; A17-B8-C30; A17-B8-C31; A17-B8-C32; A17-B8-C33; A17-B8-C34;

A17-B8-C35; A17-B8-C36; A17-B8-C37; A17-B8-C38; A17-B8-C39; A17-B8-C40;

A17-B8-C41; A17-B8-C42; A17-B8-C43; A17-B8-C44; A17-B8-C45; A17-B8-C46;

A18-B8-C1; A18-B8-C2; A18-B8-C3; A18-B8-C4; A18-B8-C5; A18-B8-C6;

A18-B8-C7; A18-B8-C8; A18-B8-C9; A18-B8-C10; A18-B8-Cll; A18-B8-C12;

A18-B8-C13; A18-B8-C14; A18-B8-C15; A18-B8-C16; A18-B8-C17; A18-B8-C18;

A18-B8-C19; A18-B8-C20; A18-B8-C21; A18-B8-C22; A18-B8-C23; A18-B8-C24;

A18-B8-C25; A18-B8-C26; A18-B8-C27; A18-B8-C28; A18-B8-C29; A18-B8-C30;

A18-B8-C31; A18-B8-C32; A18-B8-C33; A18-B8-C34; A18-B8-C35; A18-B8-C36;

A18-B8-C37; A18-B8-C38; A18-B8-C39; A18-B8-C40; A18-B8-C41; A18-B8-C42;

A18-B8-C43; A18-B8-C44; A18-B8-C45; A18-B8-C46; A19-B8-C1; A19-B8-C2;

A19-B8-C3; A19-B8-C4; A19-B8-C5; A19-B8-C6; A19-B8-C7; A19-B8-C8;

A19-B8-C9; A19-B8-C10; A19-B8-C11; A19-B8-C12; A19-BS-C13; A19-BS-C14;

A19-B8-C15; A19-B8-C16; A19-B8-C17; A19-B8-C18; A19-B8-C19; A19-B8-C20;

A19-B8-C21; A19-B8-C22; A19-B8-C23; A19-B8-C24; A19-BS-C25; A19-B8-C26;

A19-B8-C27; A19-BS-C28; A19-B8-C29; A19-B8-C30; A19-B8-C31; A19-B8-C32;

A19-B8-C33; A19-B8-C34; A19-B8-C35; A19-B8-C36; A19-B8-C37; A19-B8-C38;

A19-B8-C39; A19-B8-C40; A19-B8-C41; A19-B8-C42; A19-B8-C43; A19-B8-C44;

A19-B8-C45; A19-B8-C46; A20-B8-C1; A20-B8-C2; A20-B8-C3; A20-B8-C4;

A20-B8-C5; A20-B8-C6; A20-B8-C7; A20-B8-C8; A20-B8-C9; A20-B8-C10;

A20-B8-C11; A20-B8-C12; A20-B8-C13; A20-B8-C14; A20-B8-C15; A20-B8-C16;

A20-B8-C17; A20-B8-C18; A20-B8-C19; A20-B8-C20; A20-B8-C21; A20-B8-C22;

A20-B8-C23; A20-B8-C24; A20-B8-C25; A20-B8-C26; A20-B8-C27; A20-B8-C28;

A20-B8-C29; A20-B8-C30; A20-B8-C31; A20-B8-C32; A20-B8-C33; A20-B8-C34;

A20-B8-C35; A20-B8-C36; A20-B8-C37; A20-B8-C38; A20-B8-C39; A20-B8-C40;

A20-B8-C41; A20-B8-C42; A20-B8-C43; A20-B8-C44; A20-BS-C45; A20-B8-C46;

A21-B8-Cl; A21-B8-C2; A21-B8-C3; A21-B8-C4; A21-B8-C5; A21-B8-C6;

A21-B8-C7; A21-B8-C8; A21-B8-C9; A21-B8-C10; A21-B8-C11; A21-B8-C12;

A21-B8-C13; A21-B8-C14; A21-B8-C15; A21-B8-C16; A21-B8-C17; A21-B8-C18;

A21-B8-C19; A21-B8-C20; A21-B8-C21; A21-B8-C22; A21-B8-C23; A21-B8-C24;

A21-B8-C25; A21-B8-C26; A21-B8-C27; A21-B8-C28; A21-B8-C29; A21-B8-C30;

A21-B8-C31; A21-B8-C32; A21-B8-C33; A21-B8-C34; A21-B8-C35; A21-B8-C36;

A21-B8-C37; A21-B8-C38; A21-B8-C39; A21-B8-C40; A21-B8-C41; A21-B8-C42;

A21-B8-C43; A21-BS-C44; A21-B8-C45; A21-B8-C46; A22-B8-Cl; A22-B8-C2;

A22-B8-C3; A22-B8-C4; A22-B8-C5; A22-B8-C6; A22-B8-C7; A22-B8-C8;

A22-B8-C9; A22-B8-C10; A22-B8-C11; A22-B8-C12; A22-B8-C13; A22-B8-C14;

A22-B8-C15; A22-B8-C16; A22-B8-C17; A22-B8-C18; A22-B8-C19; A22-B8-C20;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -68A22-B8-C21; A22-B8-C22; A22-B8-C23; A22-B8-C24; A22-B8-C25; A22-B8-C26;

A22-B8-C27; A22-B8-C28; A22-B8-C29; A22-B8-C30; A22-B8-C31; A22-B8-C32;

A22-B8-C33; A22-B8-C34; A22-B8-C35; A22-B8-C36; A22-B8-C37; A22-B8-C38;

A22-B8-C39; A22-B8-C40; A22-B8-C41; A22-B8-C42; A22-B8-C43; A22-B8-C44;

A22-B8-C45; A22-B8-C46; A23-B8-C1; A23-B8-C2; A23-B8-C3; A23-B8-C4;

A23-B8-C5; A23-B8-C6; A23-B8-C7; A23-B8-C8; A23-B8-C9; A23-B8-C10;

A23-B8-C11; A23-B8-C12; A23-B8-C13; A23-B8-C14; A23-B8-C15; A23-B8-C16;

A23-B8-C17; A23-B8-C18; A23-B8-C19; A23-B8-C20; A23-B8-C21; A23-B8-C22;

A23-B8-C23; A23-B8-C24; A23-B8-C25; A23-B8-C26; A23-B8-C27; A23-B8-C28;

A23-B8-C29; A23-B8-C30; A23-B8-C31; A23-B8-C32; A23-B8-C33; A23-B8-C34;

A23-B8-C35; A23-B8-C36; A23-B8-C37; A23-B8-C38; A23-B8-C39; A23-B8-C40;

A23-B8-C41; A23-B8-C42; A23-B8-C43; A23-B8-C44; A23-B8-C45; A23-B8-C46;

A24-B8-C1; A24-B8-C2; A24-B8-C3; A24-B8-C4; A24-B8-C5; A24-B8-C6;

A24-B8-C7; A24-B8-C8; A24-B8-C9; A24-B8-C10; A24-B8-C11; A24-B8-C12;

A24-B8-C13; A24-B8-C14; A24-B8-C15; A24-B8-C16; A24-B8-C17; A24-B8-C18;

A24-B8-C19; A24-B8-C20; A24-B8-C21; A24-B8-C22; A24-B8-C23; A24-B8-C24;

A24-B8-C25; A24-B8-C26; A24-B8-C27; A24-B8-C28; A24-B8-C29; A24-B8-C30;

A24-B8-C31; A24-B8-C32; A24-B8-C33; A24-B8-C34; A24-B8-C35; A24-B8-C36;

A24-B8-C37; A24-B8-C38; A24-B8-C39; A24-B8-C40; A24-B8-C41; A24-B8-C42;

A24-B8-C43; A24-B8-C44; A24-B8-C45; A24-B8-C46; A25-B8-C1; A25-B8-C2;

A25-B8-C3; A25-B8-C4; A25-B8-C5; A25-B8-C6; A25-B8-C7; A25-B8-C8;

A25-B8-C9; A25-B8-C10; A25-B8-C11; A25-B8-C12; A25-B8-C13; A25-B8-C14;

A25-B8-C15; A25-B8-C16; A25-B8-C17; A25-B8-C18; A25-B8-C19; A25-B8-C20;

A25-B8-C21; A25-B8-C22; A25-B8-C23; A25-B8-C24; A25-B8-C25; A25-B8-C26;

A25-B8-C27; A25-B8-C28; A25-B8-C29; A25-B8-C30; A25-B8-C31; A25-B8-C32;

A25-B8-C33; A25-B8-C34; A25-B8-C35; A25-B8-C36; A25-B8-C37; A25-B8-C38;

A25-B8-C39; A25-B8-C40; A25-B8-C41; A25-B8-C42; A25-B8-C43; A25-B8-C44;

A25-B8-C45; A25-B8-C46; A26-B8-C1; A26-B8-C2; A26-B8-C3; A26-B8-C4;

A26-B8-C5; A26-B8-C6; A26-B8-C7; A26-B8-C8; A26-B8-C9; A26-B8-C10;

A26-B8-C11; A26-B8-C12; A26-B8-C13; A26-B8-C14; A26-B8-C15; A26-B8-C16;

A26-B8-C17; A26-B8-C18; A26-B8-C19; A26-B8-C20; A26-B8-C21; A26-B8-C22;

A26-B8-C23; A26-B8-C24; A26-B8-C25; A26-B8-C26; A26-B8-C27; A26-B8-C28;

A26-B8-C29; A26-B8-C30; A26-B8-C31; A26-B8-C32; A26-B8-C33; A26-B8-C34;

A26-B8-C35; A26-B8-C36; A26-B8-C37; A26-B8-C38; A26-B8-C39; A26-B8-C40;

A26-B8-C41; A26-B8-C42; A26-B8-C43; A26-B8-C44; A26-B8-C45; A26-B8-C46;

A27-B8-C1; A27-B8-C2; A27-B8-C3; A27-B8-C4; A27-B8-C5; A27-B8-C6;

A27-B8-C7; A27-B8-C8; A27-B8-C9; A27-B8-C10; A27-B8-C11; A27-B8-C12;

A27-B8-C13; A27-B8-C14; A27-B8-C15; A27-B8-C16; A27-B8-C17; A27-B8-C18;

A27-B8-C19; A27-B8-C20; A27-B8-C21; A27-B8-C22; A27-B8-C23; A27-B8-C24;

A27-B8-C25; A27-B8-C26; A27-B8-C27; A27-B8-C28; A27-B8-C29; A27-B8-C30;

A27-B8-C31; A27-B8-C32; A27-B8-C33; A27-B8-C34; A27-B8-C35; A27-B8-C36;

A27-B8-C37; A27-B8-C38; A27-B8-C39; A27-B8-C40; A27-B8-C41; A27-B8-C42;

A27-B8-C43; A27-B8-C44; A27-B8-C45; A27-B8-C46; A28-B8-C1; A28-B8-C2;

A28-B8-C3; A28-B8-C4; A28-B8-C5; A28-B8-C6; A28-B8-C7; A28-B8-C8;

A28-B8-C9; A28-B8-C10; A28-B8-C11; A28-B8-C12; A28-B8-C13; A28-B8-C14;

A28-B8-C15; A28-B8-C16; A28-B8-C17; A28-B8-C18; A28-B8-C19; A28-B8-C20;

A28-B8-C21; A28-B8-C22; A28-B8-C23; A28-B8-C24; A28-B8-C25; A28-B8-C26;

A28-B8-C27; A28-B8-C28; A28-B8-C29; A28-B8-C30; A28-B8-C31; A28-B8-C32;

A28-B8-C33; A28-B8-C34; A28-B8-C35; A28-B8-C36; A28-B8-C37; A28-B8-C38;

A28-B8-C39; A28-B8-C40; A28-B8-C41; A28-B8-C42; A28-B8-C43; A28-B8-C44;

A28-B8-C45; A28-B8-C46; Al-B9-Cl; Al-B9-C2; Al-B9-C3; Al-B9-C4;

Al-B9-C5; Al-B9-C6; Al-B9-C7; Al-B9-C8; Al-B9-C9; Al-B9-C10;

Al-B9-C11; Al-B9-C12; Al-B9-C13; Al-B9-C14; Al-B9-C15; Al-B9-C16;

Al-B9-C17; Al-B9-C18; Al-B9-C19; Al-B9-C20; Al-B9-C21; Al-B9-C22;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -69A1-B9-C23; Al-B9-C24; Al-B9-C25; Al-B9-C26; Al-B9-C27; Al-B9-C28;

Al-B9-C29; Al-B9-C30; Al-B9-C31; Al-B9-C32; Al-B9-C33; Al-B9-C34;

Al-B9-C35; Al-B9-C36; Al-B9-C37; Al-B9-C38; Al-B9-C39; Al-B9-C40;

Al-B9-C41; Al-B9-C42; Al-B9-C43; Al-B9-C44; Al-B9-C45; Al-B9-C46;

A2-B9-C1; A2-B9-C2; A2-B9-C3; A2-B9-C4; A2-B9-C5; A2-B9-C6;

A2-B9-C7; A2-B9-C8; A2-B9-C9; A2-B9-C10; A2-B9-C11; A2-B9-C12;

A2-B9-C13; A2-B9-C14; A2-B9-C15; A2-B9-C16; A2-B9-C17; A2-B9-C18;

A2-B9-C19; A2-B9-C20; A2-B9-C21; A2-B9-C22; A2-B9-C23; A2-B9-C24;

A2-B9-C25; A2-B9-C26; A2-B9-C27; A2-B9-C28; A2-B9-C29; A2-B9-C30;

A2-B9-C31; A2-B9-C32; A2-B9-C33; A2-B9-C34; A2-B9-C35; A2-B9-C36;

A2-B9-C37; A2-B9-C38; A2-B9-C39; A2-B9-C40; A2-B9-C41; A2-B9-C42;

A2-B9-C43; A2-B9-C44; A2-B9-C45; A2-B9-C46; A3-B9-C1; A3-B9-C2;

A3-B9-C3; A3-B9-C4; A3-B9-C5; A3-B9-C6; A3-B9-C7; A3-B9-C8;

A3-B9-C9; A3-B9-C10; A3-B9-C11; A3-B9-C12; A3-B9-C13; A3-B9-C14;

A3-B9-C15; A3-B9-C16; A3-B9-C17; A3-B9-C18; A3-B9-C19; A3-B9-C20;

A3-B9-C21; A3-B9-C22; A3-B9-C23; A3-B9-C24; A3-B9-C25; A3-B9-C26;

A3-B9-C27; A3-B9-C28; A3-B9-C29; A3-B9-C30; A3-B9-C31; A3-B9-C32;

A3-B9-C33; A3-B9-C34; A3-B9-C35; A3-B9-C36; A3-B9-C37; A3-B9-C38;

A3-B9-C39; A3-B9-C40; A3-B9-C41; A3-B9-C42; A3-B9-C43; A3-B9-C44;

A3-B9-C45; A3-B9-C46; A4-B9-C1; A4-B9-C2; A4-B9-C3; A4-B9-C4;

A4-B9-C5; A4-B9-C6; A4-B9-C7; A4-B9-C8; A4-B9-C9; A4-B9-C10;

A4-B9-C11; A4-B9-C12; A4-B9-C13; A4-B9-C14; A4-B9-C15; A4-B9-C16;

A4-B9-C17; A4-B9-C18; A4-B9-C19; A4-B9-C20; A4-B9-C21; A4-B9-C22;

A4-B9-C23; A4-B9-C24; A4-B9-C25; A4-B9-C26; A4-B9-C27; A4-B9-C28;

A4-B9-C29; A4-B9-C30; A4-B9-C31; A4-B9-C32; A4-B9-C33; A4-B9-C34;

A4-B9-C35; A4-B9-C36; A4-B9-C37; A4-B9-C38; A4-B9-C39; A4-B9-C40;

A4-B9-C41; A4-B9-C42; A4-B9-C43; A4-B9-C44; A4-B9-C45; A4-B9-C46;

A5-B9-C1; A5-B9-C2; A5-B9-C3; A5-B9-C4; A5-B9-C5; A5-B9-C6;

A5-B9-C7; A5-B9-C8; A5-B9-C9; A5-B9-C10; A5-B9-C11; A5-B9-C12;

A5-B9-C13; A5-B9-C14; A5-B9-C15; A5-B9-C16; A5-B9-C17; A5-B9-C18;

A5-B9-C19; A5-B9-C20; A5-B9-C21; A5-B9-C22; A5-B9-C23; A5-B9-C24;

A5-B9-C25; A5-B9-C26; A5-B9-C27; A5-B9-C28; A5-B9-C29; A5-B9-C30;

A5-B9-C31; A5-B9-C32; A5-B9-C33; A5-B9-C34; A5-B9-C35; A5-B9-C36;

A5-B9-C37; A5-B9-C38; A5-B9-C39; A5-B9-C40; A5-B9-C41; A5-B9-C42;

A5-B9-C43; A5-B9-C44; A5-B9-C45; A5-B9-C46; A6-B9-C1; A6-B9-C2;

A6-B9-C3; A6-B9-C4; A6-B9-C5; A6-B9-C6; A6-B9-C7; A6-B9-C8;

A6-B9-C9; A6-B9-C10; A6-B9-C11; A6-B9-C12; A6-B9-C13; A6-B9-C14;

A6-B9-C15; A6-B9-C16; A6-B9-C17; A6-B9-C18; A6-B9-C19; A6-B9-C20;

A6-B9-C21; A6-B9-C22; A6-B9-C23; A6-B9-C24; A6-B9-C25; A6-B9-C26;

A6-B9-C27; A6-B9-C28; A6-B9-C29; A6-B9-C30; A6-B9-C31; A6-B9-C32;

A6-B9-C33; A6-B9-C34; A6-B9-C35; A6-B9-C36; A6-B9-C37; A6-B9-C38;

A6-B9-C39; A6-B9-C40; A6-B9-C41; A6-B9-C42; A6-B9-C43; A6-B9-C44;

A6-B9-C45; A6-B9-C46; A7-B9-Cl; A7-B9-C2; A7-B9-C3; A7-B9-C4;

A7-B9-C5; A7-B9-C6; A7-B9-C7; A7-B9-C8; A7-B9-C9; A7-B9-C10;

A7-B9-C11; A7-B9-C12; A7-B9-C13; A7-B9-C14; A7-B9-C15; A7-B9-C16;

A7-B9-C17; A7-B9-C18; A7-B9-C19; A7-B9-C20; A7-B9-C21; A7-B9-C22;

A7-B9-C23; A7-B9-C24; A7-B9-C25; A7-B9-C26; A7-B9-C27; A7-B9-C28;

A7-B9-C29; A7-B9-C30; A7-B9-C31; A7-B9-C32; A7-B9-C33; A7-B9-C34;

A7-B9-C35; A7-B9-C36; A7-B9-C37; A7-B9-C38; A7-B9-C39; A7-B9-C40;

A7-B9-C41; A7-B9-C42; A7-B9-C43; A7-B9-C44; A7-B9-C45; A7-B9-C46;

A8-B9-Cl; A8-B9-C2; A8-B9-C3; A8-B9-C4; A8-B9-C5; A8-B9-C6;

AS-B9-C7; A8-B9-C8; A8-B9-C9; A8-B9-C10; A8-B9-C11; A8-B9-C12;

AS-B9-C13; A8-B9-C14; A8-B9-C15; A8-B9-C16; A8-B9-C17; A8-B9-C18;

AS-B9-C19; A8-B9-C20; A8-B9-C21; A8-B9-C22; A8-B9-C23; A8-B9-C24;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -70A8-B9-C25; A8-B9-C26; A8-B9-C27; A8-B9-C28; A8-B9-C29; A8-B9-C30;

A8-B9-C31; A8-B9-C32; A8-B9-C33; A8-B9-C34; A8-B9-C35; A8-B9-C36;

A8-B9-C37; A8-B9-C38; A8-B9-C39; A8-B9-C40; A8-B9-C41; A8-B9-C42;

A8-B9-C43; A8-B9-C44; A8-B9-C45; A8-B9-C46; A9-B9-Cl; A9-B9-C2;

A9-B9-C3; A9-B9-C4; A9-B9-C5; A9-B9-C6; A9-B9-C7; A9-B9-C8;

A9-B9-C9; A9-B9-C10; A9-B9-Cl1; A9-B9-Cl2; A9-B9-C13; A9-B9-C14;

A9-B9-C15; A9-B9-C16; A9-B9-C17; A9-B9-C18; A9-B9-C19; A9-B9-C20;

A9-B9-C21; A9-B9-C22; A9-B9-C23; A9-B9-C24; A9-B9-C25; A9-B9-C26;

A9-B9-C27; A9-B9-C28; A9-B9-C29; A9-B9-C30; A9-B9-C31; A9-B9-C32;

A9-B9-C33; A9-B9-C34; A9-B9-C35; A9-B9-C36; A9-B9-C37; A9-B9-C38;

A9-B9-C39; A9-B9-C40; A9-B9-C41; A9-B9-C42; A9-B9-C43; A9-B9-C44;

A9-B9-C45; A9-B9-C46; A10-B9-Cl; A10-B9-C2; A10-B9-C3; A10-B9-C4;

A10-B9-C5; A10-B9-C6; A10-B9-C7; A10-B9-C8; A10-B9-C9; A10-B9-C10;

A10-B9-C11; A10-B9-C12; A10-B9-C13; A10-B9-C14; A10-B9-C15; A10-B9-C16;

A10-B9-C17; A10-B9-C18; A10-B9-C19; A10-B9-C20; A10-B9-C21; A10-B9-C22;

A10-B9-C23; A10-B9-C24; A10-B9-C25; A10-B9-C26; A10-B9-C27; A10-B9-C28;

A10-B9-C29; A10-B9-C30; A10-B9-C31; A10-B9-C32; A10-B9-C33; A10-B9-C34;

A10-B9-C35; A10-B9-C36; A10-B9-C37; A10-B9-C38; A10-B9-C39; A10-B9-C40;

A10-B9-C41; A10-B9-C42; A10-B9-C43; A10-B9-C44; A10-B9-C45; A10-B9-C46;

All-B9-C1; All-B9-C2; All-B9-C3; All-B9-C4; All-B9-C5; All-B9-C6;

All-B9-C7; All-B9-C8; All-B9-C9; All-B9-C10; All-B9-C11; All-B9-C12;

All-B9-C13; All-B9-C14; All-B9-C15; All-B9-C16; All-B9-C17; All-B9-C18;

All-B9-C19; All-B9-C20; All-B9-C21; All-B9-C22; All-B9-C23; All-B9-C24;

All-B9-C25; All-B9-C26; All-B9-C27; All-B9-C28; All-B9-C29; All-B9-C30;

All-B9-C31; All-B9-C32; All-B9-C33; All-B9-C34; All-B9-C35; All-B9-C36;

All-B9-C37; All-B9-C38; All-B9-C39; All-B9-C40; All-B9-C41; All-B9-C42;

All-B9-C43; All-B9-C44; All-B9-C45; All-B9-C46; A12-B9-C1; A12-B9-C2;

A12-B9-C3; A12-B9-C4; A12-B9-C5; A12-B9-C6; A12-B9-C7; A12-B9-C8;

A12-B9-C9; A12-B9-C10; A12-B9-Cll; A12-B9-C12; A12-B9-C13; A12-B9-C14;

A12-B9-C15; A12-B9-C16; A12-B9-C17; A12-B9-C18; A12-B9-C19; A12-B9-C20;

A12-B9-C21; A12-B9-C22; A12-B9-C23; A12-B9-C24; A12-B9-C25; A12-B9-C26;

A12-B9-C27; A12-B9-C28; A12-B9-C29; A12-B9-C30; A12-B9-C31; A12-B9-C32;

A12-B9-C33; A12-B9-C34; A12-B9-C35; A12-B9-C36; A12-B9-C37; A12-B9-C38;

A12-B9-C39; A12-B9-C40; A12-B9-C41; A12-B9-C42; A12-B9-C43; A12-B9-C44;

A12-B9-C45; A12-B9-C46; A13-B9-C1; A13-B9-C2; A13-B9-C3; A13-B9-C4;

A13-B9-C5; A13-B9-C6; A13-B9-C7; A13-B9-C8; A13-B9-C9; A13-B9-C10;

A13-B9-Cl1; A13-B9-C12; A13-B9-C13; A13-B9-C14; A13-B9-C15; A13-B9-C16;

A13-B9-C17; A13-B9-C18; A13-B9-C19; A13-B9-C20; A13-B9-C21; A13-B9-C22;

A13-B9-C23; A13-B9-C24; A13-B9-C25; A13-B9-C26; A13-B9-C27; A13-B9-C28;

A13-B9-C29; A13-B9-C30; A13-B9-C31; A13-B9-C32; A13-B9-C33; A13-B9-C34;

A13-B9-C35; A13-B9-C36; A13-B9-C37; A13-B9-C38; A13-B9-C39; A13-B9-C40;

A13-B9-C41; A13-B9-C42; A13-B9-C43; A13-B9-C44; A13-B9-C45; A13-B9-C46;

A14-B9-C1; A14-B9-C2; A14-B9-C3; A14-B9-C4; A14-B9-C5; A14-B9-C6;

A14-B9-C7; A14-B9-C8; A14-B9-C9; A14-B9-C10; A14-B9-Cl1; A14-B9-C12;

A14-B9-C13; A14-B9-C14; A14-B9-C15; A14-B9-Cl6; A14-B9-C17; A14-B9-C18;

A14-B9-C19; A14-B9-C20; A14-B9-C21; A14-B9-C22; A14-B9-C23; A14-B9-C24;

A14-B9-C25; A14-B9-C26; A14-B9-C27; A14-B9-C28; A14-B9-C29; A14-B9-C30;

A14-B9-C31; A14-B9-C32; A14-B9-C33; A14-B9-C34; A14-B9-C35; A14-B9-C36;

A14-B9-C37; A14-B9-C38; A14-B9-C39; A14-B9-C40; A14-B9-C41; A14-B9-C42;

A14-B9-C43; A14-B9-C44; A14-B9-C45; A14-B9-C46; A15-B9-C1; A15-B9-C2;

A15-B9-C3; A15-B9-C4; A15-B9-C5; A15-B9-C6; A15-B9-C7; A15-B9-C8;

A15-B9-C9; A15-B9-C10; A15-B9-C11; A15-B9-C12; A15-B9-C13; A15-B9-C14;

A15-B9-Cl5; A15-B9-Cl6; A15-B9-C17; A15-B9-C18; A15-B9-C19; A15-B9-C20;

A15-B9-C21; A15-B9-C22; A15-B9-C23; A15-B9-C24; A15-B9-C25; A15-B9-C26;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -71A15-B9-C27; A15-B9-C28; A15-B9-C29; A15-B9-C30; A15-B9-C31; A15-B9-C32;

A15-B9-C33; A15-B9-C34; A15-B9-C35; A15-B9-C36; A15-B9-C37; A15-B9-C38;

A15-B9-C39; A15-B9-C40; A15-B9-C41; A15-B9-C42; A15-B9-C43; A15-B9-C44;

A15-B9-C45; A15-B9-C46; A16-B9-C1; A16-B9-C2; A16-B9-C3; A16-B9-C4;

A16-B9-C5; A16-B9-C6; A16-B9-C7; A16-B9-C8; A16-B9-C9; A16-B9-C10;

A16-B9-C11; A16-B9-C12; A16-B9-C13; A16-B9-C14; A16-B9-C15; A16-B9-C16;

A16-B9-C17; A16-B9-C18; A16-B9-C19; A16-B9-C20; A16-B9-C21; A16-B9-C22;

A16-B9-C23; A16-B9-C24; A16-B9-C25; A16-B9-C26; A16-B9-C27; A16-B9-C28;

A16-B9-C29; A16-B9-C30; A16-B9-C31; A16-B9-C32; A16-B9-C33; A16-B9-C34;

A16-B9-C35; A16-B9-C36; A16-B9-C37; A16-B9-C38; A16-B9-C39; A16-B9-C40;

A16-B9-C41; A16-B9-C42; A16-B9-C43; A16-B9-C44; A16-B9-C45; A16-B9-C46;

A17-B9-Cl; A17-B9-C2; A17-B9-C3; A17-B9-C4; A17-B9-C5; A17-B9-C6;

A17-B9-C7; A17-B9-C8; A17-B9-C9; A17-B9-C10; A17-B9-C11; A17-B9-C12;

A17-B9-C13; A17-B9-C14; A17-B9-C15; A17-B9-C16; A17-B9-C17; A17-B9-C18;

A17-B9-C19; A17-B9-C20; A17-B9-C21; A17-B9-C22; A17-B9-C23; A17-B9-C24;

A17-B9-C25; A17-B9-C26; A17-B9-C27; A17-B9-C28; A17-B9-C29; A17-B9-C30;

A17-B9-C31; A17-B9-C32; A17-B9-C33; A17-B9-C34; A17-B9-C35; A17-B9-C36;

A17-B9-C37; A17-B9-C38; A17-B9-C39; A17-B9-C40; A17-B9-C41; A17-B9-C42;

A17-B9-C43; A17-B9-C44; A17-B9-C45; A17-B9-C46; A18-B9-C1; A18-B9-C2;

A18-B9-C3; A18-B9-C4; A18-B9-C5; A18-B9-C6; A18-B9-C7; A18-B9-C8;

A18-B9-C9; A18-B9-C10; A18-B9-C11; A18-B9-C12; A18-B9-C13; A18-B9-C14;

A18-B9-C15; A18-B9-C16; A18-B9-C17; A18-B9-C18; A18-B9-C19; A18-B9-C20;

A18-B9-C21; A18-B9-C22; A18-B9-C23; A18-B9-C24; A18-B9-C25; A18-B9-C26;

A18-B9-C27; A18-B9-C28; A18-B9-C29; A18-B9-C30; A18-B9-C31; A18-B9-C32;

A18-B9-C33; A18-B9-C34; A18-B9-C35; A18-B9-C36; A18-B9-C37; A18-B9-C38;

A18-B9-C39; A18-B9-C40; A18-B9-C41; A18-B9-C42; A18-B9-C43; A18-B9-C44;

A18-B9-C45; A18-B9-C46; A19-B9-C1; A19-B9-C2; A19-B9-C3; A19-B9-C4;

A19-B9-C5; A19-B9-C6; A19-B9-C7; A19-B9-C8; A19-B9-C9; A19-B9-C10;

A19-B9-C11; A19-B9-C12; A19-B9-C13; A19-B9-C14; A19-B9-C15; A19-B9-C16;

A19-B9-C17; A19-B9-C18; A19-B9-C19; A19-B9-C20; A19-B9-C21; A19-B9-C22;

A19-B9-C23; A19-B9-C24; A19-B9-C25; A19-B9-C26; A19-B9-C27; A19-B9-C28;

A19-B9-C29; A19-B9-C30; A19-B9-C31; A19-B9-C32; A19-B9-C33; A19-B9-C34;

A19-B9-C35; A19-B9-C36; A19-B9-C37; A19-B9-C38; A19-B9-C39; A19-B9-C40;

A19-B9-C41; A19-B9-C42; A19-B9-C43; A19-B9-C44; A19-B9-C45; A19-B9-C46;

A20-B9-Cl; A20-B9-C2; A20-B9-C3; A20-B9-C4; A20-B9-C5; A20-B9-C6;

A20-B9-C7; A20-B9-C8; A20-B9-C9; A20-B9-C10; A20-B9-C11; A20-B9-C12;

A20-B9-C13; A20-B9-C14; A20-B9-C15; A20-B9-C16; A20-B9-C17; A20-B9-C18;

A20-B9-C19; A20-B9-C20; A20-B9-C21; A20-B9-C22; A20-B9-C23; A20-B9-C24;

A20-B9-C25; A20-B9-C26; A20-B9-C27; A20-B9-C28; A20-B9-C29; A20-B9-C30;

A20-B9-C31; A20-B9-C32; A20-B9-C33; A20-B9-C34; A20-B9-C35; A20-B9-C36;

A20-B9-C37; A20-B9-C38; A20-B9-C39; A20-B9-C40; A20-B9-C41; A20-B9-C42;

A20-B9-C43; A20-B9-C44; A20-B9-C45; A20-B9-C46; A21-B9-C1; A21-B9-C2;

A21-B9-C3; A21-B9-C4; A21-B9-C5; A21-B9-C6; A21-B9-C7; A21-B9-C8;

A21-B9-C9; A21-B9-C10; A21-B9-Cll; A21-B9-C12; A21-B9-C13; A21-B9-C14;

A21-B9-C15; A21-B9-C16; A21-B9-C17; A21-B9-C18; A21-B9-C19; A21-B9-C20;

A21-B9-C21; A21-B9-C22; A21-B9-C23; A21-B9-C24; A21-B9-C25; A21-B9-C26;

A21-B9-C27; A21-B9-C28; A21-B9-C29; A21-B9-C30; A21-B9-C31; A21-B9-C32;

A21-B9-C33; A21-B9-C34; A21-B9-C35; A21-B9-C36; A21-B9-C37; A21-B9-C38;

A21-B9-C39; A21-B9-C40; A21-B9-C41; A21-B9-C42; A21-B9-C43; A21-B9-C44;

A21-B9-C45; A21-B9-C46; A22-B9-Cl; A22-B9-C2; A22-B9-C3; A22-B9-C4;

A22-B9-C5; A22-B9-C6; A22-B9-C7; A22-B9-C8; A22-B9-C9; A22-B9-C10;

A22-B9-C11; A22-B9-C12; A22-B9-C13; A22-B9-C14; A22-B9-C15; A22-B9-C16;

A22-B9-C17; A22-B9-C18; A22-B9-C19; A22-B9-C20; A22-B9-C21; A22-B9-C22;

A22-B9-C23; A22-B9-C24; A22-B9-C25; A22-B9-C26; A22-B9-C27; A22-B9-C28;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -72A22-B9-C29; A22-B9-C30; A22-B9-C31; A22-B9-C32; A22-B9-C33; A22-B9-C34;

A22-B9-C35; A22-B9-C36; A22-B9-C37; A22-B9-C38; A22-B9-C39; A22-B9-C40;

A22-B9-C41; A22-B9-C42; A22-B9-C43; A22-B9-C44; A22-B9-C45; A22-B9-C46;

A23-B9-C1; A23-B9-C2; A23-B9-C3; A23-B9-C4; A23-B9-C5; A23-B9-C6;

A23-B9-C7; A23-B9-C8; A23-B9-C9; A23-B9-C10; A23-B9-C11; A23-B9-C12;

A23-B9-C13; A23-B9-C14; A23-B9-C15; A23-B9-C16; A23-B9-C17; A23-B9-C18;

A23-B9-C19; A23-B9-C20; A23-B9-C21; A23-B9-C22; A23-B9-C23; A23-B9-C24;

A23-B9-C25; A23-B9-C26; A23-B9-C27; A23-B9-C28; A23-B9-C29; A23-B9-C30;

A23-B9-C31; A23-B9-C32; A23-B9-C33; A23-B9-C34; A23-B9-C35; A23-B9-C36;

A23-B9-C37; A23-B9-C38; A23-B9-C39; A23-B9-C40; A23-B9-C41; A23-B9-C42;

A23-B9-C43; A23-B9-C44; A23-B9-C45; A23-B9-C46; A24-B9-Cl; A24-B9-C2;

A24-B9-C3; A24-B9-C4; A24-B9-C5; A24-B9-C6; A24-B9-C7; A24-B9-C8;

A24-B9-C9; A24-B9-C10; A24-B9-C11; A24-B9-C12; A24-B9-C13; A24-B9-C14;

A24-B9-C15; A24-B9-C16; A24-B9-C17; A24-B9-C18; A24-B9-C19; A24-B9-C20;

A24-B9-C21; A24-B9-C22; A24-B9-C23; A24-B9-C24; A24-B9-C25; A24-B9-C26;

A24-B9-C27; A24-B9-C28; A24-B9-C29; A24-B9-C30; A24-B9-C31; A24-B9-C32;

A24-B9-C33; A24-B9-C34; A24-B9-C35; A24-B9-C36; A24-B9-C37; A24-B9-C38;

A24-B9-C39; A24-B9-C40; A24-B9-C41; A24-B9-C42; A24-B9-C43; A24-B9-C44;

A24-B9-C45; A24-B9-C46; A25-B9-C1; A25-B9-C2; A25-B9-C3; A25-B9-C4;

A25-B9-C5; A25-B9-C6; A25-B9-C7; A25-B9-C8; A25-B9-C9; A25-B9-C10;

A25-B9-Cll; A25-B9-C12; A25-B9-C13; A25-B9-C14; A25-B9-C15; A25-B9-C16;

A25-B9-C17; A25-B9-C18; A25-B9-C19; A25-B9-C20; A25-B9-C21; A25-B9-C22;

A25-B9-C23; A25-B9-C24; A25-B9-C25; A25-B9-C26; A25-B9-C27; A25-B9-C28;

A25-B9-C29; A25-B9-C30; A25-B9-C31; A25-B9-C32; A25-B9-C33; A25-B9-C34;

A25-B9-C35; A25-B9-C36; A25-B9-C37; A25-B9-C38; A25-B9-C39; A25-B9-C40;

A25-B9-C41; A25-B9-C42; A25-B9-C43; A25-B9-C44; A25-B9-C45; A25-B9-C46;

A26-B9-C1; A26-B9-C2; A26-B9-C3; A26-B9-C4; A26-B9-C5; A26-B9-C6;

A26-B9-C7; A26-B9-C8; A26-B9-C9; A26-B9-C10; A26-B9-C11; A26-B9-C12;

A26-B9-C13; A26-B9-C14; A26-B9-C15; A26-B9-C16; A26-B9-C17; A26-B9-C18;

A26-B9-C19; A26-B9-C20; A26-B9-C21; A26-B9-C22; A26-B9-C23; A26-B9-C24;

A26-B9-C25; A26-B9-C26; A26-B9-C27; A26-B9-C28; A26-B9-C29; A26-B9-C30;

A26-B9-C31; A26-B9-C32; A26-B9-C33; A26-B9-C34; A26-B9-C35; A26-B9-C36;

A26-B9-C37; A26-B9-C38; A26-B9-C39; A26-B9-C40; A26-B9-C41; A26-B9-C42;

A26-B9-C43; A26-B9-C44; A26-B9-C45; A26-B9-C46; A27-B9-C1; A27-B9-C2;

A27-B9-C3; A27-B9-C4; A27-B9-C5; A27-B9-C6; A27-B9-C7; A27-B9-C8;

A27-B9-C9; A27-B9-C10; A27-B9-Cll; A27-B9-C12; A27-B9-C13; A27-B9-C14;

A27-B9-C15; A27-B9-C16; A27-B9-C17; A27-B9-C18; A27-B9-C19; A27-B9-C20;

A27-B9-C21; A27-B9-C22; A27-B9-C23; A27-B9-C24; A27-B9-C25; A27-B9-C26;

A27-B9-C27; A27-B9-C28; A27-B9-C29; A27-B9-C30; A27-B9-C31; A27-B9-C32;

A27-B9-C33; A27-B9-C34; A27-B9-C35; A27-B9-C36; A27-B9-C37; A27-B9-C38;

A27-B9-C39; A27-B9-C40; A27-B9-C41; A27-B9-C42; A27-B9-C43; A27-B9-C44;

A27-B9-C45; A27-B9-C46; A28-B9-Cl; A28-B9-C2; A28-B9-C3; A28-B9-C4;

A28-B9-C5; A28-B9-C6; A28-B9-C7; A28-B9-C8; A28-B9-C9; A28-B9-C10;

A28-B9-Cll; A28-B9-C12; A28-B9-C13; A28-B9-C14; A28-B9-C15; A28-B9-C16;

A28-B9-C17; A28-B9-C18; A28-B9-C19; A28-B9-C20; A28-B9-C21; A28-B9-C22;

A28-B9-C23; A28-B9-C24; A28-B9-C25; A28-B9-C26; A28-B9-C27; A28-B9-C28;

A28-B9-C29; A28-B9-C30; A28-B9-C31; A28-B9-C32; A28-B9-C33; A28-B9-C34;

A28-B9-C35; A28-B9-C36; A28-B9-C37; A28-B9-C38; A28-B9-C39; A28-B9-C40;

A28-B9-C41; A28-B9-C42; A28-B9-C43; A28-B9-C44; A28-B9-C45; A28-B9-C46;

Al-BlO-Cl; Al-B10-C2; Al-B10-C3; Al-B10-C4; Al-B10-C5; Al-B10-C6;

Al-B10-C7; Al-B10-C8; Al-B10-C9; Al-B10-C10; Al-B10-Cil; Al-B10-C12;

Al-B10-C13; Al-B10-C14; Al-B10-C15; Al-B10-C16; Al-B10-C17; Al-B10-C18;

Al-B10-C19; Al-B10-C20; Al-B10-C21; Al-B10-C22; Al-B10-C23; Al-B10-C24;

Al-B10-C25; Al-B10-C26; Al-B10-C27; Al-B10-C28; Al-B10-C29; Al-B10-C30;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -73Al-B10-C31; A1-B10-C32; Al-B10-C33; Al-B10-C34; A1-B10-C35; A1-B10-C36;

Al-B10-C37; Al-B10-C38; Al-B10-C39; Al-B10-C40; Al-B10-C41; Al-B10-C42;

Al-B10-C43; Al-B10-C44; Al-B10-C45; Al-B10-C46; A2-B10-Cl; A2-B10-C2;

A2-B10-C3; A2-B10-C4; A2-B10-C5; A2-B10-C6; A2-B10-C7; A2-B10-C8;

A2-B10-C9; A2-B10-C10; A2-B10-Cll; A2-B10-C12; A2-B10-C13; A2-B10-C14;

A2-B10-C15; A2-B10-C16; A2-B10-C17; A2-B10-C18; A2-B10-C19; A2-B10-C20;

A2-B10-C21; A2-B10-C22; A2-B10-C23; A2-B10-C24; A2-B10-C25; A2-B10-C26;

A2-B10-C27; A2-B10-C28; A2-B10-C29; A2-B10-C30; A2-B10-C31; A2-B10-C32;

A2-B10-C33; A2-B10-C34; A2-B10-C35; A2-B10-C36; A2-B10-C37; A2-B10-C38;

A2-B10-C39; A2-B10-C40; A2-B10-C41; A2-B10-C42; A2-B10-C43; A2-B10-C44;

A2-B10-C45; A2-B10-C46; A3-B10-Cl; A3-B10-C2; A3-B10-C3; A3-B10-C4;

A3-B10-C5; A3-B10-C6; A3-B10-C7; A3-B10-C8; A3-B10-C9; A3-B10-C10;

A3-B10-C11; A3-B10-C12; A3-B10-C13; A3-B10-C14; A3-B10-C15; A3-B10-C16;

A3-B10-C17; A3-B10-C18; A3-B10-C19; A3-B10-C20; A3-B10-C21; A3-B10-C22;

A3-B10-C23; A3-B10-C24; A3-B10-C25; A3-B10-C26; A3-B10-C27; A3-B10-C28;

A3-B10-C29; A3-B10-C30; A3-B10-C31; A3-B10-C32; A3-B10-C33; A3-B10-C34;

A3-B10-C35; A3-B10-C36; A3-B10-C37; A3-B10-C38; A3-B10-C39; A3-B10-C40;

A3-B1O-C41; A3-B10-C42; A3-B1O-C43; A3-B10-C44; A3-B10-C45; A3-B10-C46;

A4-B10-C1; A4-B10-C2; A4-B10-C3; A4-B10-C4; A4-B10-C5; A4-B10-C6;

A4-B10-C7; A4-B10-C8; A4-B10-C9; A4-B10-C10; A4-B10-Cll; A4-B10-C12;

A4-B10-C13; A4-B10-C14; A4-B10-C15; A4-B10-C16; A4-B10-C17; A4-B10-C18;

A4-B10-C19; A4-B10-C20; A4-B10-C21; A4-B10-C22; A4-B10-C23; A4-B10-C24;

A4-B10-C25; A4-B10-C26; A4-B10-C27; A4-B10-C28; A4-B10-C29; A4-B10-C30;

A4-B10-C31; A4-B10-C32; A4-B10-C33; A4-B10-C34; A4-B10-C35; A4-B10-C36;

A4-B10-C37; A4-B10-C38; A4-B10-C39; A4-B10-C40; A4-B10-C41; A4-B10-C42;

A4-B10-C43; A4-B10-C44; A4-B10-C45; A4-B10-C46; A5-B10-Cl; A5-B10-C2;

A5-B10-C3; A5-B10-C4; A5-B10-C5; A5-B10-C6; A5-B10-C7; A5-B10-C8;

A5-B10-C9; A5-B10-C10; A5-B10-C11; A5-B10-C12; A5-B10-C13; A5-B10-C14;

A5-B10-C15; A5-B10-C16; A5-B10-C17; A5-B10-C18; A5-B10-C19; A5-B10-C20;

A5-B10-C21; A5-B10-C22; A5-B10-C23; A5-B10-C24; A5-B10-C25; A5-B10-C26;

A5-B10-C27; A5-B1O-C28; A5-B1O-C29; A5-B10-C30; A5-B10-C31; A5-B1O-C32;

A5-B10-C33; A5-B10-C34; A5-B10-C35; A5-B10-C36; A5-B10-C37; A5-B10-C38;

A5-B10-C39; A5-B10-C40; A5-B10-C41; A5-B10-C42; A5-B10-C43; A5-B10-C44;

A5-B10-C45; A5-B10-C46; A6-B10-C1; A6-B10-C2; A6-B10-C3; A6-B10-C4;

A6-B10-C5; A6-B10-C6; A6-B10-C7; A6-B10-C8; A6-B10-C9; A6-B10-C10;

A6-B10-C11; A6-B10-C12; A6-B10-C13; A6-B10-C14; A6-B10-C15; A6-B10-C16;

A6-B10-C17; A6-B10-C18; A6-B10-C19; A6-B10-C20; A6-B10-C21; A6-B10-C22;

A6-B10-C23; A6-B10-C24; A6-B10-C25; A6-B10-C26; A6-B10-C27; A6-B10-C28;

A6-B10-C29; A6-B10-C30; A6-B10-C31; A6-B10-C32; A6-B10-C33; A6-B10-C34;

A6-B10-C35; A6-B10-C36; A6-B10-C37; A6-B10-C38; A6-B10-C39; A6-B10-C40;

A6-B10-C41; A6-B10-C42; A6-B10-C43; A6-B10-C44; A6-B10-C45; A6-B10-C46;

A7-B10-C1; A7-B10-C2; A7-B10-C3; A7-B10-C4; A7-B10-C5; A7-B10-C6;

A7-B10-C7; A7-B10-C8; A7-B10-C9; A7-B10-C10; A7-B10-C11; A7-B10-C12;

A7-B10-C13; A7-B1O-C14; A7-B1O-C15; A7-B10-C16; A7-B10-C17; A7-B10-C18;

A7-B10-C19; A7-B10-C20; A7-B10-C21; A7-B10-C22; A7-B10-C23; A7-B10-C24;

A7-B10-C25; A7-B10-C26; A7-B10-C27; A7-B10-C28; A7-B10-C29; A7-B10-C30;

A7-B10-C31; A7-B10-C32; A7-B10-C33; A7-B10-C34; A7-B10-C35; A7-B10-C36;

A7-B10-C37; A7-B10-C38; A7-B10-C39; A7-B10-C40; A7-B10-C41; A7-B10-C42;

A7-B10-C43; A7-B10-C44; A7-B10-C45; A7-B10-C46; A8-B10-Cl; A8-B10-C2;

A8-B10-C3; A8-B10-C4; A8-B10-C5; A8-B10-C6; A8-B10-C7; A8-B10-C8;

A8-B10-C9; A8-B10-C10; A8-B10-C11; A8-B10-C12; A8-B10-C13; A8-B10-C14;

A8-B10-C15; A8-B10-C16; A8-B10-C17; A8-B10-C18; A8-B10-C19; A8-B10-C20;

A8-B10-C21; A8-B10-C22; A8-B10-C23; A8-B10-C24; A8-B10-C25; A8-B10-C26;

A8-B10-C27; A8-B10-C28; A8-B10-C29; A8-B10-C30; A8-B10-C31; A8-B10-C32;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -74A8-B10-C33; A8-B10-C34; A8-B10-C35; A8-B10-C36; A8-B10-C37; A8-B10-C38;

A8-B10-C39; A8-B10-C40; A8-B10-C41; A8-B10-C42; A8-B10-C43; A8-B10-C44;

A8-B10-C45; A8-B10-C46; A9-B10-C1; A9-B10-C2; A9-B10-C3; A9-B10-C4;

A9-B10-C5; A9-B10-C6; A9-B10-C7; A9-B10-C8; A9-B10-C9; A9-B10-C10;

A9-B10-C11; A9-B10-C12; A9-B10-C13; A9-B10-C14; A9-B10-C15; A9-B10-C16;

A9-B10-C17; A9-B10-C18; A9-B10-C19; A9-B10-C20; A9-B10-C21; A9-B10-C22;

A9-B10-C23; A9-B10-C24; A9-B10-C25; A9-B10-C26; A9-B10-C27; A9-B10-C28;

A9-B10-C29; A9-B10-C30; A9-B10-C31; A9-B10-C32; A9-B10-C33; A9-B10-C34;

A9-B10-C35; A9-B10-C36; A9-B10-C37; A9-B10-C38; A9-B10-C39; A9-B10-C40;

A9-B10-C41; A9-B10-C42; A9-B10-C43; A9-B10-C44; A9-B10-C45; A9-B10-C46;

A10-B10-C1; A10-B10-C2; A10-B10-C3; A10-B10-C4; A10-B10-C5; A10-B10-C6;

A10-B10-C7; A10-B10-C8; A10-B10-C9; A10-Bl0- A10-BlO- A10-BlO C10; C11; C12;

A10-B10- A10-B10- A10-B10- A10-B10- A10-Bl0- A10-BlOC13; C14; C15; C16; C17; C18;

A10-B10- A10-B10- AlO-B10- A10-BlO- A10-B10- A10-BlOC19; C20; C21; C22; C23; C24;

Al0-B10- A10-B10- A10-B10- Al0-B10- AlO-B10- A10-B10C25; C26; C27; C28; C29; C30;

Al0-B10- A10-B10- A10-Bl0- A10-BlO- A10-Bl0- A10-BlOC31; C32; C33; C34; C35; C36;

A10-B10- A10-B10- A10-BlO- A10-BlO- A10-Bl0- A10-B10C37; C38; C39; C40; C41; C42;

A10-B10- A10-B10- A10-B10- A10-B10- All-Bl0-Cl; All-B10-C2;

C43; C44; C45; C46;

All-B10-C3; All-B10-C4; All-B10-C5; All-B10-C6; All-B10-C7; All-B10-C8;

All-B10-C9; All-BlO- All-B10- All-B10- All-BlO- All-B10C10; Cll; C12; C13; C14;

All-B10- All-B10- Ail-B10- All-B10- All-BlO- All-B10C15; C16; C17; C18; C19; C20;

All-B10- All-BlO- All-BlO- All-BlO- All-B10- All-B10C21; C22; C23; C24; C25; C26;

All-B10- All-BlO- All-BlO- All-BlO- All-B10- All-B10C27; C28; C29; C30; C31; C32;

All-B10- All-BlO- All-B10- All-B10- All-B10- All-BlOC33; C34; C35; C36; C37; C38;

All-B10- Ail-B10- All-B10- All-B10- All-B10- All-B10C39; C40; C41; C42; C43; C44;

All-BlO- All-B10- A12-B10-C1; A12-B10-C2; A12-B10-C3; A12-BlO-C4;

C45; C46;

A12-B10-C5; A12-B10-C6; A12-B10-C7; A12-B10-C8; A12-B10-C9; A12-B10C10;

A12-B10- A12-B10- A12-B10- A12-B10- A12-B10- A12-B10Cll; C12; C13; C14; C15; C16;

A12-B10- A12-B10- A12-B10- A12-B10- A12-B10- A12-B10C17; C18; C19; C20; C21; C22;

A12-B10- A12-B10- A12-B10- A12-B10- A12-Bl0- A12-B10C23; C24; C25; C26; C27; C28;

A12-B10- A12-B10- A12-Bi0- A12-Bl0- A12-Bl0- A12-B10C29; C30; C31; C32; C33; C34;

A12-BlO- A12-Bl0- A12-B10- A12-B10- A12-B10- A12-Bl0C35; C36; C37; C38; C39; C40;

A12-B10- A12-B10- A12-B10- A12-B10- A12-B10- A12-B10C41; C42; C43; C44; C45; C46;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -75A13-B10-Cl; A13-B10-C2; A13-B10-C3; A13-B10-C4; A13-B10-C5; A13-B10-C6;

A13-B10-C7; A13-B10-C8; A13-B10-C9; A13-B10- A13-B10- A13-B10 C10; C11; C12;

A13-B10- A13-BlO- A13-B10- A13-B10- A13-B10- A13-B10C13; C14; C15; C16; C17; C18;

A13-B10- A13-B10- A13-BlO- A13-B10- A13-B10- A13-B10C19; C20; C21; C22; C23; C24;

A13-B10- A13-B10- A13-B10- A13-B10- A13-B10- A13-B10C25; C26; C27; C28; C29; C30;

A13-B10- A13-B10- A13-B10- A13-B10- A13-B10- A13-B10C31; C32; C33; C34; C35; C36;

A13-B10- A13-B10- A13-B10- A13-B10- A13-B10- A13-B10C37; C38; C39; C40; C41; C42;

A13-B10- A13-B10- A13-B10- A13-B10- A14-B10-Cl; A14-B10-C2;

C43; C44; C45; C46;

A14-B10-C3; A14-B10-C4; A14-B10-C5; A14-B10-C6; A14-B10-C7; A14-B10-C8;

A14-B10-C9; A14-B10- A14-B10- A14-B10- A14-B10- A14-B10C10; Cil; C12; C13; C14;

A14-B10- A14-B10- A14-B10- A14-B10- A14-B10- A14-B10C15; C16; C17; C18; C19; C20;

A14-B10- A14-B10- A14-B10- A14-B10- A14-B10- A14-B10C21; C22; C23; C24; C25; C26;

A14-B10- A14-B10- A14-B10- A14-B10- A14-B10- A14-B10C27; C28; C29; C30; C31; C32;

A14-B10- A14-B10- A14-B10- A14-B10- A14-B10- A14-B10C33; C34; C35; C36; C37; C38;

A14-B10- A14-B10- A14-B10- A14-BlO- A14-B10- A14-B10C39; C40; C41; C42; C43; C44;

A14-B10- A14-B10- A15-B10-C1; A15-B10-C2; A15-B10-C3; A15-B10-C4;

C45; C46;

A15-B10-C5; A15-B10-C6; A15-B10-C7; A15-B10-C8; A15-Bl0-C9; A15-B10C10;

A15-Bl0- A15-B10- A15-B10- A15-B10- A15-B10- A15-B10Cll; C12; C13; C14; C15; C16;

A15-B10- A15-B10- A15-B10- A15-B10- A15-B10- A15-B10C17; C18; C19; C20; C21; C22;

A15-B10- A15-B10- A15-B10- A15-B10- A15-BlO- A15-B10C23; C24; C25; C26; C27; C28;

A15-BlO- A15-B10- A15-B10- A15-B10- A15-B10- A15-B10C29; C30; C31; C32; C33; C34;

A15-B10- A15-B10- A15-Bl0- A15-B10- A15-B10- A15-B10C35; C36; C37; C38; C39; C40;

A15-BlO- A15-B10- A15-B10- A15-B10- A15-B10- A15-B10C41; C42; C43; C44; C45; C46;

A16-B10-C1; A16-B10-C2; A16-B10-C3; A16-B10-C4; A16-B10-C5; A16-B10-C6;

A16-B10-C7; A16-B10-C8; A16-BlO-C9; A16-B10- A16-B10- A16-B10 C10; Cl l; C12;

A16-B10- A16-BlO- A16-B10- A16-B10- A16-B10- A16-B10C13; C14; C15; C16; C17; C18;

A16-B10- A16-B10- A16-B10- A16-Bl0- A16-B10- A16-B10C19; C20; C21; C22; C23; C24;

A16-B10- A16-B10- A16-B10- A16-B10- A16-B10- A16-B10C25; C26; C27; C28; C29; C30;

A16-B10- A16-B10- A16-B10- A16-B10- A16-B10- A16-B10 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -76C31; C32; C33; C34; C35; C36;

A16-B10- A16-B10- A16-BIO- A16-B10- A16-B10- A16-BIOC37; C38; C39; C40; C41; C42;

A16-B10- A16-B10- A16-BIO- A16-B10- A17-B10-C1; A17-B10-C2;

C43; C44; C45; C46;

A17-BlO-C3; A17-BlO-C4; A17-BlO-C5; A17-BlO-C6; A17-BlO-C7; A17-BlO-C8;

A17-B10-C9; A17-B10- A17-BIO- A17-BlO- A17-B10- A17-B1OC1O; Cli; C12; C13; C14;

A17-BlO- A17-BlO- A17-BlO- A17-B10- A17-B10- A17-BiOC15; C16; C17; C18; C19; C20;

A17-BlO- A17-BiO- A17-BlO- A17-BlO- A17-B10- A17-B1OC21; C22; C23; C24; C25; C26;

A17-BlO- A17-B10- A17-BlO- A17-BiO- A17-BiO- A17-B10C27; C28; C29; C30; C31; C32;

A17-B10- A17-B10- A17-B10- A17-B10- A17-B10- A17-B1OC33; C34; C35; C36; C37; C38;

A17-BlO- A17-BIO- A17-BlO- A17-BIO- A17-B10- A17-B10C39; C40; C41; C42; C43; C44;

A17-B10- A17-B10- A18-B10-Cl; A18-BlO-C2; A18-BlO-C3; A18-BlO-C4;

C45; C46;

A18-B10-C5; A18-BlO-C6; A18-BiO-C7; A18-B10-C8; A18-B10-C9; A18-B1OC1O;

A18-B10- A18-BlO- A18-B10- A18-B10- A18-BlO- A18-BiOCii; C12; C13; C14; C15; C16;

A18-B10- A18-B10- A18-B10- A18-B10- A18-BlO- A18-B10C17; C18; C19; C20; C21; C22;

A18-B10- A18-B10- A18-B10- A18-BiO- A18-BiO- A18-BiOC23; C24; C25; C26; C27; C28;

A18-BlO- A18-BlO- A18-B10- A18-B10- A18-BlO- A18-BiOC29; C30; C31; C32; C33; C34;

A18-B10- A18-B10- A18-B10- A18-B10- A18-BlO- A18-B10C35; C36; C37; C38; C39; C40;

A18-B10- A18-B10- A18-B10- A18-B10- A18-B10- A18-B10C41; C42; C43; C44; C45; C46;

A19-BiO-Cl; A19-B10-C2; A19-BlO-C3; A19-B10-C4; A19-B10-C5; A19-B10-C6;

A19-BlO-C7; A19-B10-C8; A19-BlO-C9; A19-BlO- A19-B10- A19-B1O C1O; Cll; C12;

A19-B10- A19-BiO- A19-B10- A19-BiO- A19-BIO- A19-BiOC13; C14; C15; C16; C17; C18;

A19-B10- A19-B10- A19-BlO- A19-BlO- A19-B10- A19-B10C19; C20; C21; C22; C23; C24;

A19-B10- A19-BlO- A19-B10- A19-B10- A19-B10- A19-B10C25; C26; C27; C28; C29; C30;

A19-Bi0- A19-BiO- A19-B10- A19-BlO- A19-B10- A19-BiOC31; C32; C33; C34; C35; C36;

A19-BlO- A19-BlO- A19-B10- A19-B10- A19-B10- A19-B10C37; C38; C39; C40; C41; C42;

A19-BlO- A19-BiO- A19-B10- A19-B10- A20-BlO-Cl; A20-B10-C2;

C43; C44; C45; - C46;

A20-B10-C3; A20-BiO-C4; A20-BlO-C5; A20-B10-C6; A20-BIO-C7; A20-B10-C8;

A20-BlO-C9; A20-BiO- A20-B10- A20-B10- A20-B10- A20B10-CIO; Cll; C12; C13; C14;

A20-B10- A20-B10- A20-BiO- A20-BiO- A20-B10- A20-1310C15; C16; C17; C18; C19; C20;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -77A20-B10- A20-B10- A20-B10- A20-B10- A20-B10- A20-B10C21; C22; C23; C24; C25; C26;

A20-B10- A20-B10- A20-B10- A20-B10- A20-B10- A20-B10C27; C28; C29; C30; C31; C32;

A20-B10- A20-B10- A20-B10- A20-B10- A20-B10- A20-B10C33; C34; C35; C36; C37; C38;

A20-B10- A20-B10- A20-B10- A20-B10- A20-B10- A20-B10C39; C40; C41; C42; C43; C44;

A20-B10- A20-B10- A21-B10-C1; A21-B10-C2; A21-B10-C3; A21-B10-C4;

C45; C46;

A21-B10-C5; A21-B10-C6; A21-B10-C7; A21-B10-C8; A21-B10-C9; A21-B10C10;

A21-B10- A21-B10- A21-B10- A21-B10- A21-B10- A21-B10Cll; C12; C13; C14; C15; C16;

A21-B10- A21-B10- A21-B10- A21-B10- A21-B10- A21-B10C17; C18; C19; C20; C21; C22;

A21-B10- A21-B10- A21-B10- A21-B10- A21-B10- A21-B10C23; C24; C25; C26; C27; C28;

A21-B10- A21-B10- A21-B10- A21-B10- A21-B10- A21-B10C29; C30; C31; C32; C33; C34;

A21-B10- A21-B10- A21-B10- A21-B10- A21-B10- A21-B10C35; C36; C37; C38; C39; C40;

A21-B10- A21-B10- A21-B10- A21-B10- A21-B10- A21-B10C41; C42; C43; C44; C45; C46;

A22-B10-Cl; A22-B10-C2; A22-B10-C3; A22-B10-C4; A22-B10-C5; A22-B10-C6;

A22-B10-C7; A22-B10-C8; A22-BlO-C9; A22-B10- A22-B10- A22-B10 C10; C11; C12;

A22-B10- A22-B10- A22-B10- A22-Bl0- A22-B10- A22-B10C13; C14; C15; C16; C17; C18;

A22-B10- A22-B10- A22-B10- A22-Bl0- A22-B10- A22-B10C19; C20; C21; C22; C23; C24;

A22-B10- A22-B10- A22-B10- A22-Bl0- A22-B10- A22-Bl0C25; C26; C27; C28; C29; C30;

A22-B10- A22-BlO- A22-B10- A22-B10- A22-B10- A22-B10C31; C32; C33; C34; C35; C36;

A22-B10- A22-B10- A22-B10- A22-B10- A22-B10- A22-B10C37; C38; C39; C40; C41; C42;

A22-B10- A22-B10- A22-B10- A22-B10- A23-B10-Cl; A23-B10-C2;

C43; C44; C45; C46;

A23-B10-C3; A23-B10-C4; A23-B10-C5; A23-B10-C6; A23-B10-C7; A23-Bl0-C8;

A23-B10-C9; A23-B10- A23-B10- A23-B10- A23-B10- A23-Bi0C10; C11; C12; C13; C14;

A23-B10- A23-B10- A23-B10- A23-B10- A23-B10- A23-B10C15; C16; C17; C18; C19; C20;

A23-Bl0- A23-B10- A23-BlO- A23-B10- A23-B10- A23-B10C21; C22; C23; C24; C25; C26;

A23-B10- A23-B10- A23-B10- A23-B10- A23-BlO- A23-B10C27; C28; C29; C30; C31; C32;

A23-B10- A23-B10- A23-B10- A23-B10- A23-B10- A23-B10C33; C34; C35; C36; C37; C38;

A23-B10- A23-B10- A23-BlO- A23-B10- A23-B10- A23-B10C39; C40; C41; C42; C43; C44;

A23-B10- A23-B10- A24-B10-Cl; A24-B10-C2; A24-B10-C3; A24-B10-C4;

C45; C46;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -78A24-B10-C5; A24-B10-C6; A24-B10-C7; A24-B10-C8; A24-B10-C9; A24-B10 C10;

A24-B10- A24-B10- A24-B10- A24-B10- A24-B10- A24-B10Cll; C12; C13; C14; C15; C16;

A24-B10- A24-B10- A24-B10- A24-B10- A24-B10- A24-B10C17; C18; C19; C20; C21; C22;

A24-BlO- A24-B10- A24-B10- A24-B10- A24-B10- A24-B10C23; C24; C25; C26; C27; C28;

A24-B10- A24-B10- A24-B10- A24-B10- A24-B10- A24-B10C29; C30; C31; C32; C33; C34;

A24-B10- A24-B10- A24-B10- A24-B10- A24-B10- A24-B10C35; C36; C37; C38; C39; C40;

A24-B10- A24-B10- A24-B10- A24-B10- A24-BlO- A24-B10C41; C42; C43; C44; C45; C46;

A25-B10-C1; A25-B10-C2; A25-B10-C3; A25-B10-C4; A25-B10-C5; A25-B10-C6;

A25-B10-C7; A25-B10-C8; A25-B10-C9; A25-B10- A25-B10- A25-B10 C10; C11; C12;

A25-B10- A25-B10- A25-B10- A25-B10- A25-B10- A25-B10C13; C14; C15; C16; C17; C18;

A25-B10- A25-B10- A25-BlO- A25-B10- A25-B10- A25-B10C19; C20; C21; C22; C23; C24;

A25-B10- A25-B10- A25-B10- A25-BlO- A25-B10- A25-B10C25; C26; C27; C28; C29; C30;

A25-B10- A25-B10- A25-B10- A25-B10- A25-B10- A25-B10C31; C32; C33; C34; C35; C36;

A25-B10- A25-B10- A25-B10- A25-B10- A25-B10- A25-B10C37; C38; C39; C40; C41; C42;

A25-B10- A25-B10- A25-B10- A25-B10- A26-B10-C1; A26-B10-C2;

C43; C44; C45; C46;

A26-B10-C3; A26-B10-C4; A26-BlO-C5; A26-BlO-C6; A26-B10-C7; A26-B10-C8;

A26-B10-C9; A26-B10- A26-B10- A26-B10- A26-BlO- A26-B10C10; Cll; C12; C13; C14;

A26-B10- A26-B10- A26-B10- A26-B10- A26-BlO- A26-B10C15; C16; C17; C18; C19; C20;

A26-B10- A26-B10- A26-B10- A26-B10- A26-BlO- A26-B10C21; C22; C23; C24; C25; C26;

A26-B10- A26-B10- A26-B10- A26-B10- A26-B10- A26-B10C27; C28; C29; C30; C31; C32;

A26-B10- A26-B10- A26-B10- A26-B10- A26-B10- A26-B10C33; C34; C35; C36; C37; C38;

A26-B10- A26-B10- A26-B10- A26-B10- A26-B10- A26-B10C39; C40; C41; C42; C43; C44;

A26-B10- A26-B10- A27-B10-C1; A27-BlO-C2; A27-B10-C3; A27-B10-C4;

C45; C46;

A27-B10-C5; A27-B10-C6; A27-B10-C7; A27-B10-C8; A27-B10-C9; A27-B10C10;

A27-B10- A27-B10- A27-B10- A27-B10- A27-B10- A27-B10Cll; C12; C13; C14; C15; C16;

A27-B10- A27-B10- A27-B10- A27-B10- A27-Bl0- A27-B10C17; C18; C19; C20; C21; C22;

A27-B10- A27-B10- A27-B10- A27-B10- A27-B10- A27-B10C23; C24; C25; C26; C27; C28;

A27-B10- A27-B10- A27-B10- A27-B10- A27-BlO- A27-B10C29; C30; C31; C32; C33; C34;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -79A27-B10- A27-B10- A27-B10- A27-B10- A27-B10- A27-B10C35; C36; C37; C38; C39; C40;

A27-B10- A27-B10- A27-B10- A27-BlO- A27-BlO- A27-B10C41; C42; C43; C44; C45; C46;

A28-Bl0-Cl; A28-B10-C2; A28-B10-C3; A28-B10-C4; A28-B10-C5; A28-B10-C6;

A28-B10-C7; A28-B10-C8; A28-B10-C9; A28-B10- A28-B10- A28-B10 C10; C11; C12;

A28-B10- A28-B10- A28-B10- A28-B10- A28-B10- A28-B10C13; C14; C15; C16; C17; C18;

A28-B10- A28-B10- A28-B10- A28-B10- A28-B10- A28-B10C19; C20; C21; C22; C23; C24;

A28-B10- A28-B10- A28-B10- A28-B10- A28-B10- A28-B10C25; C26; C27; C28; C29; C30;

A28-B10- A28-B10- A28-B10- A28-B10- A28-B10- A28-B10C31; C32; C33; C34; C35; C36;

A28-B10- A28-B10- A28-B10- A28-B10- A28-B10- A28-B10C37; C38; C39; C40; C41; C42;

A28-B10- A28-B10- A28-B10- A28-B10- Al-B11-C1; Al-B11-C2;

C43; C44; C45; C46;

Al-B11-C3; Al-B11-C4; Al-Bll-C5; Al-B11-C6; Al-Bl1-C7; Al-Bll-C8;

Al-B11-C9; Al-Bll-ClO; Al-Bll-Cll; Al-Bll-C12; Al-B11-C13; Al-B1l-C14;

Al-B11-C15; Al-B11-C16; Al-B11-C17; Al-Bll-C18; Al-B11-C19; Al-B11-C20;

Al-B11-C21; Al-B11-C22; Al-B11-C23; Al-Bll-C24; Al-B11-C25; Al-Bil-C26;

Al-Bll-C27; Al-B11-C28; Al-Bll-C29; Al-B11-C30; Al-Bll-C31; Al-Bll-C32;

Al-B11-C33; Al-B11-C34; Al-Bll-C35; Al-B11-C36; Al-B11-C37; Al-B11-C38;

Al-B11-C39; Al-B1l-C40; Al-B11-C41; Al-B11-C42; Al-Bll-C43; Al-Bll-C44;

Al-Bl1-C45; Al-B11-C46; A2-B11-C1; A2-B11-C2; A2-B11-C3; A2-B11-C4;

A2-Bll-C5; A2-Bll-C6; A2-B11-C7; A2-Bll-C8; A2-Bl1-C9; A2-Bll-C10;

A2-Bll-C11; A2-B11-C12; A2-B1l-C13; A2-Bll-C14; A2-Bll-C15; A2-Bll-C16;

A2-B11-C17; A2-Bll-C18; A2-Bll-C19; A2-Bll-C20; A2-Bll-C21; A2-Bll-C22;

A2-Bll-C23; A2-B1l-C24; A2-Bll-C25; A2-Bll-C26; A2-B1l-C27; A2-Bll-C28;

A2-Bll-C29; A2-B11-C30; A2-B11-C31; A2-B11-C32; A2-B11-C33; A2-B11-C34;

A2-Bll-C35; A2-Bll-C36; A2-B11-C37; A2-Bll-C38; A2-Bll-C39; A2-Bll-C40;

A2-B11-C41; A2-B11-C42; A2-B11-C43; A2-Bll-C44; A2-B11-C45; A2-Bll-C46;

A3-Bll-Cl; A3-B11-C2; A3-B11-C3; A3-B11-C4; A3-Bl1-C5; A3-Bll-C6;

A3-B11-C7; A3-B11-C8; A3-Bl1-C9; A3-B11-C10; A3-Bll-C11; A3-Bll-C12;

A3-B1l-C13; A3-Bll-C14; A3-Bll-C15; A3-Bll-C16; A3-B11-C17; A3-B11-C18;

A3-Bll-C19; A3-Bll-C20; A3-Bll-C21; A3-Bll-C22; A3-Bll-C23; A3-B11-C24;

A3-B11-C25; A3-B11-C26; A3-B11-C27; A3-B11-C28; A3-B11-C29; A3-Bll-C30;

A3-Bll-C31; A3-B11-C32; A3-Bll-C33; A3-B11-C34; A3-B11-C35; A3-B11-C36;

A3-Bll-C37; A3-Bl1-C38; A3-B11-C39; A3-Bll-C40; A3-B11-C41; A3-Bll-C42;

A3-Bll-C43; A3-B11-C44; A3-B11-C45; A3-Bll-C46; A4-B11-C1; A4-B1l-C2;

A4-Bll-C3; A4-Bll-C4; A4-B11-C5; A4-Bll-C6; A4-Bll-C7; A4-Bll-CS;

A4-Bll-C9; A4-Bll-C10; A4-Bll-Cll; A4-Bll-C12; A4-Bll-C13; A4-Bll-C14;

A4-Bll-C15; A4-Bll-C16; A4-B11-C17; A4-Bll-C18; A4-Bll-C19; A4-B11-C20;

A4-Bll-C21; A4-Bll-C22; A4-Bll-C23; A4-Bll-C24; A4-Bll-C25; A4-B11-C26;

A4-B11-C27; A4-B1l-C28; A4-Bll-C29; A4-Bll-C30; A4-B11-C31; A4-Bll-C32;

A4-Bll-C33; A4-Bll-C34; A4-B11-C35; A4-B1l-C36; A4-B11-C37; A4-Bll-C38;

A4-Bll-C39; A4-B11-C40; A4-B11-C41; A4-Bll-C42; A4-B11-C43; A4-B11-C44;

A4-B11-C45; A4-Bll-C46; A5-Bll-Cl; A5-Bll-C2; A5-Bll-C3; A5-Bll-C4;

A5-Bll-C5; A5-Bll-C6; A5-Bll-C7; A5-Bll-C8; A5-B11-C9; A5-Bll-C10;

A5-B11-C11; A5-Bll-C12; A5-B11-C13; A5-Bll-C14; A5-B11-C15; A5-Bll-C16;

A5-Bll-C17; A5-Bll-C18; A5-Bll-C19; A5-Bll-C20; A5-Bll-C21; A5-Bll-C22;

A5-Bll-C23; A5-B11-C24; A5-B1l-C25; A5-Bll-C26; A5-Bll-C27; A5-Bll-C28;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -80A5-B11-C29; A5-B11-C30; A5-B11-C31; A5-B11-C32; A5-B11-C33; A5-B11-C34;

A5-B11-C35; A5-B11-C36; A5-B11-C37; A5-B11-C38; A5-B11-C39; A5-B11-C40;

A5-Bll-C41; A5-B11-C42; A5-B11-C43; A5-B11-C44; A5-B11-C45; A5-B11-C46;

A6-B11-C1; A6-B11-C2; A6-B11-C3; A6-B11-C4; A6-B11-C5; A6-Bll-C6;

A6-Bll-C7; A6-B11-C8; A6-Bll-C9; A6-Bll-C10; A6-Bll-Cll; A6-Bll-C12;

A6-Bll-C13; A6-B11-C14; A6-B11-C15; A6-B11-C16; A6-B11-C17; A6-B11-C18;

A6-B11-C19; A6-B11-C20; A6-B11-C21; A6-B11-C22; A6-B11-C23; A6-B11-C24;

A6-B11-C25; A6-B11-C26; A6-B11-C27; A6-B11-C28; A6-B11-C29; A6-B11-C30;

A6-B11-C31; A6-B11-C32; A6-B11-C33; A6-B11-C34; A6-B11-C35; A6-B11-C36;

A6-B11-C37; A6-B11-C38; A6-B11-C39; A6-B11-C40; A6-B11-C41; A6-B11-C42;

A6-B11-C43; A6-B11-C44; A6-B11-C45; A6-Bll-C46; A7-B11-Cl; A7-B11-C2;

A7-Bll-C3; A7-B11-C4; A7-Bll-C5; A7-Bll-C6; A7-B11-C7; A7-B11-C8;

A7-B11-C9; A7-B11-C10; A7-B11-C11; A7-B11-C12; A7-B11-C13; A7-B11-C14;

A7-B11-C15; A7-B11-C16; A7-B11-C17; A7-Bll-C18; A7-B11-C19; A7-B11-C20;

A7-Bll-C21; A7-B11-C22; A7-B11-C23; A7-B11-C24; A7-B11-C25; A7-B11-C26;

A7-B11-C27; A7-B11-C28; A7-B1l-C29; A7-B11-C30; A7-B11-C31; A7-B11-C32;

A7-B11-C33; A7-B11-C34; A7-Bl1-C35; A7-Bll-C36; A7-Bl1-C37; A7-Bll-C38;

A7-B11-C39; A7-B11-C40; A7-B11-C41; A7-B11-C42; A7-Bil-C43; A7-B11-C44;

A7-Bll-C45; A7-Bll-C46; A8-Bli-Cl; A8-Bll-C2; A8-Bll-C3; A8-B11-C4;

A8-B11-C5; A8-B11-C6; A8-B11-C7; A8-B11-C8; A8-Bll-C9; A8-B11-C10;

A8-B11-C11; A8-B11-C12; A8-B11-C13; A8-B11-C14; A8-B11-C15; A8-B11-C16;

A8-B11-C17; A8-B11-C18; A8-B11-C19; A8-Bl1-C20; A8-B11-C21; A8-B11-C22;

A8-B11-C23; A8-B11-C24; A8-Bl1-C25; A8-B11-C26; A8-B11-C27; A8-Bl1-C28;

A8-B11-C29; A8-B11-C30; A8-B11-C31; A8-B11-C32; A8-B11-C33; A8-Bll-C34;

A8-B11-C35; A8-B11-C36; A8-B11-C37; A8-B11-C38; A8-B11-C39; A8-B11-C40;

A8-B11-C41; A8-B11-C42; A8-B11-C43; A8-B11-C44; A8-B11-C45; A8-B11-C46;

A9-B11-C1; A9-B11-C2; A9-Bll-C3; A9-Bll-C4; A9-Bll-C5; A9-B11-C6;

A9-B11-C7; A9-B11-C8; A9-B11-C9; A9-B11-C10; A9-Bll-C11; A9-Bll-C12;

A9-Bll-C13; A9-B11-C14; A9-B11-C15; A9-B11-C16; A9-B11-C17; A9-B11-C18;

A9-Bll-C19; A9-B11-C20; A9-B11-C21; A9-B11-C22; A9-Bll-C23; A9-B11-C24;

A9-B11-C25; A9-B11-C26; A9-B11-C27; A9-B11-C28; A9-B11-C29; A9-B11-C30;

A9-B11-C31; A9-Bll-C32; A9-B11-C33; A9-B11-C34; A9-B11-C35; A9-Bll-C36;

A9-Bll-C37; A9-Bll-C38; A9-Bll-C39; A9-Bll-C40; A9-Bll-C41; A9-Bll-C42;

A9-B11-C43; A9-B1l-C44; A9-B11-C45; A9-Bll-C46; A10-B11-Cl; A10-B11-C2;

A10-Bll-C3; A10-B11-C4; A10-B11-C5; A10-B11-C6; A10-B11-C7; A10-B11-C8;

A10-Bll-C9; A10-Bil- A10-Bil- A10-Bli- A10-Bll- A10-Bi1 C10; Cl!; C12; C13; C14;

A10-B11- A10-Bll- A10-Bil- AlO-Bll- A10-B11- A10-BllC15; C16; C17; C18; C19; C20;

A10-Bll- A10-Bli- AlO-Bll- A10-Bli- A10-Bll- A10-BllC21; C22; C23; C24; C25; C26;

A10-Bll- A10-B11- A10-B11- Al0-B11- A10-Bil- A10-Bi1C27; C28; C29; C30; C31; C32;

A10-B1l- AlO-Bll- A10-B11- AlO-Bll- A10-Bil- A10-Bi1C33; C34; C35; C36; C37; C38;

A10-B11- A10-B11- A10-Bil- A10-Bil- A10-Bll- Al0-BliC39; C40; C41; C42; C43; C44;

A10-Bli- A10-B11- All-B11-Cl; All-Bll-C2; All-B11-C3; All-Bll-C4;

C45; C46;

All-Bll-C5; All-Bil-C6; All-B11-C7; All-Bll-C8; All-B11-C9; All-B11C10;

All-Bll- All-Bll- All-Bil- All-Bll- All-Bll- All-BllCll; C12; C13; C14; C15; C16;

All-B11- All-Bll- All-Bil- All-B11- All-B11- All-Bll CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -81C17; C18; C19; C20; C21; C22;

All-Bll- All-Bll- All-Bll- All-Bil- All-Bll- All-Bl1C23; C24; C25; C26; C27; C28;

All-Bll- All-Bll- All-Bll- All-Bll- All-Bll- All-Bl1C29; C30; C31; C32; C33; C34;

All-Bli- All-Bll- All-Bll- All-Bil- All-Bil- All-BllC35; C36; C37; C38; C39; C40;

All-Bll- All-Bll- All-Bll- All-Bil- All-Bll- All-B11C41; C42; C43; C44; C45; C46;

A12-Bl1-C1; A12-Bii-C2; A12-Bll-C3; A12-B11-C4; A12-Bli-C5; A12-B11-C6;

A12-B11-C7; A12-Bll-C8; A12-Bll-C9; A12-Bll- A12-B11- A12-B11 C10; C11; C12;

A12-Bll- A12-Bll- A12-Bll- A12-Bll- A12-Bll- A12-BllC13; C14; C15; C16; C17; C18;

A12-Bll- A12-Bli- A12-Bll- A12-Bll- A12-Bll- A12-BllC19; C20; C21; C22; C23; C24;

A12-Bli- A12-Bll- A12-B1l- A12-Bil- A12-Bll- A12-Bl1C25; C26; C27; C28; C29; C30;

A12-Bll- A12-Bll- A12-Bll- A12-Bll- A12-Bll- A12-BllC31; C32; C33; C34; C35; C36;

A12-B11- A12-Bll- A12-B11- A12-Bi1- A12-Bll- A12-BllC37; C38; C39; C40; C41; C42;

A12-Bll- A12-Bll- A12-B11- A12-Bll- A13-Bit-C1; A13-B11-C2;

C43; C44; C45; C46;

A13-B11-C3; A13-B11-C4; A13-Bll-C5; A13-B11-C6; A13-B11-C7; A13-Bll-C8;

A13-Bit-C9; A13-Bll- A13-B11- A13-Bll- A13-Bll- A13-BilC10; C11; C12; C13; C14;

A13-Bll- A13-Bll- A13-Bll- A13-Bi1- A13-Bll- A13-B11C15; C16; C17; C18; C19; C20;

A13-B11- A13-Bll- A13-B11- A13-B11- A13-B1l- A13-B11C21; C22; C23; C24; C25; C26;

A13-B11- A13-Bl1- A13-B11- A13-B1l- A13-Bll- A13-Bl1C27; C28; C29; C30; C31; C32;

A13-Bll- A13-Bll- A13-Bll- A13-B11- A13-Bll- A13-B11C33; C34; C35; C36; C37; C38;

A13-Bll- A13-Bll- A13-Bll- A13-Bll- A13-Bll- A13-BllC39; C40; C41; C42; C43; C44;

A13-B1l- A13-B11- A14-Bil-Cl; A14-Bll-C2; A14-Bil-C3; A14-Bll-C4;

C45; C46;

A14-Bll-C5; A14-B11-C6; A14-B11-C7; A14-Bll-C8; A14-B11-C9; A14-B11C10;

A14-B1l- A14-Bi1- A14-Bil- A14-B11- A14-Bll- A14-BllCil; C12; C13; C14; C15; C16;

A14-B11- A14-Bli- A14-Bll- A14-Bil- A14-B1l- A14-BliC17; C18; C19; C20; C21; C22;

A14-Bll- A14-Bll- A14-B1l- A14-Bll- A14-B11- A14-BllC23; C24; C25; C26; C27; C28;

A14-Bll- A14-Bll- A14-Bii- A14-B11- A14-B11- A14-BliC29; C30; C31; C32; C33; C34;

A14-Bil- A14-Bll- A14-B11- A14-B11- A14-Bil- A14-B11C35; C36; C37; C38; C39; C40;

A14-Bll- A14-Bll- A14-Bll- A14-Bll- A14-Bll- A14-BllC41; C42; C43; C44; C45; C46;

A15-B11-C1; A15-Bll-C2; A15-Bii-C3; A15-Bit-C4; A15-B11-C5; A15-Bll-C6;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -82A15-B11-C7; A15-B11-C8; A15-B11-C9; A15-B11- A15-B11- A15-B11 C10; Cll; C12;

A15-B11- A15-B1l- A15-Bl1- A15-B11- A15-Bl1- A15-Bi1C13; C14; C15; C16; C17; C18;

A15-B11- A15-Bll- A15-Bll- A15-Bll- A15-B11- A15-Bl1C19; C20; C21; C22; C23; C24;

A15-B11- A15-Bi1- A15-Bil- A15-B11- A15-Bi1- A15-Bi1C25; C26; C27; C28; C29; C30;

A15-B11- A15-Bll- A15-B11- A15-B11- A15-Bl1- A15-B11C31; C32; C33; C34; C35; C36;

A15-B11- A15-B11- A15-B11- A15-B11- A15-B11- A15-BllC37; C38; C39; C40; C41; C42;

A15-Bli- A15-B1l- A15-B11- A15-B11- A16-B1l-C1; A16-B1l-C2;

C43; C44; C45; C46;

A16-Bl1-C3; A16-B11-C4; A16-B11-C5; A16-Bl1-C6; A16-Bil-C7; A16-B11-C8;

A16-Bli-C9; A16-Bll- A16-Bll- A16-Bll- A16-Bll- A16-Bi1C10; Cll; C12; C13; C14;

A16-B11- A16-B11- A16-B11- A16-Bl1- A16-Bil- A16-Bl1C15; C16; C17; C18; C19; C20;

A16-Bi1- A16-B11- A16-B11- A16-Bil- A16-B11- A16-B11C21; C22; C23; C24; C25; C26;

A16-B11- A16-B11- A16-B11- A16-B11- A16-B1l- A16-Bl1C27; C28; C29; C30; C31; C32;

A16-Bll- A16-B11- A16-B11- A16-Bll- A16-B11- A16-Bl1C33; C34; C35; C36; C37; C38;

A16-B11- A16-Bll- A16-Bll- A16-Bll- A16-Bil- A16-BllC39; C40; C41; C42; C43; C44;

A16-B11- A16-Bl1- A17-B1l-Cl; A17-Bl1-C2; A17-B11-C3; A17-Bl1-C4;

C45; C46;

A17-Bl1-C5; A17-Bl1-C6; A17-Bl1-C7; A17-Bit-C8; A17-Bll-C9; A17-BllC10;

A17-Bll- A17-B11- A17-Bll- A17-Bll- A17-Bil- A17-BilCli; C12; C13; C14; C15; C16;

A17-B11- A17-Bl1- A17-Bll- A17-Bli- A17-B11- A17-B11C17; C18; C19; C20; C21; C22;

A17-Bll- A17-Bli- A17-B11- A17-Bll- A17-B11- A17-B11C23; C24; C25; C26; C27; C28;

A17-Bi1- A17-B1l- A17-B1l- A17-Bll- A17-Bll- A17-BllC29; C30; C31; C32; C33; C34;

A17-Bll- A17-B11- A17-B11- A17-Bll- A17-B11- A17-BliC35; C36; C37; C38; C39; C40;

A17-Bi1- A17-Bi1- A17-Bli- A17-Bi1- A17-Bll- A17-B11C41; C42; C43; C44; C45; C46;

A18-Bit-C1; A18-B1i-C2; A18-B11-C3; A18-Bl1-C4; A18-B11-C5; A18-Bl1-C6;

A18-B11-C7; A18-B11-C8; A18-Bll-C9; A18-Bll- A18-Bll- A18-B11 C10; Cll; C12;

A18-B11- A18-Bl1- A18-Bil- A18-B11- A18-Bil- A18-B1lC13; C14; C15; C16; C17; C18;

A18-Bll- A18-B11- A18-Bil- A18-Bil- A18-B11- A18-B11C19; C20; C21; C22; C23; C24;

A18-Bli- A18-B11- A18-Bll- A18-Bil- A18-Bli- A18-Bl1C25; C26; C27; C28; C29; C30;

A18-Bll- A18-B11- A18-Bll- A18-Bli- A18-Bll- A18-BllC31; C32; C33; C34; C35; C36;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -83A18-B11- A18-B11- A18-B11- A18-B11- A18-B11- A18-B11C37; C38; C39; C40; C41; C42;

A18-B11- A18-B11- A18-B11- A18-B11- A19-Bll-C1; A19-B11-C2;

C43; C44; C45; C46;

A19-B11-C3; A19-B11-C4; A19-B11-C5; A19-B11-C6; A19-B11-C7; A19-B11-C8;

A19-B11-C9; A19-B11- A19-B11- A19-B11- A19-B11- A19-B11C10; Cll; C12; C13; C14;

A19-B11- A19-B11- A19-B11- A19-B11- A19-B11- A19-Bl1C15; C16; C17; C18; C19; C20;

A19-B11- A19-B11- A19-B11- A19-Bl1- A19-B11- A19-B11C21; C22; C23; C24; C25; C26;

A19-Bl1- A19-B11- A19-B11- A19-Bll- A19-B11- A19-B1lC27; C28; C29; C30; C31; C32;

A19-B11- A19-Bll- A19-Bll- A19-B1l- A19-B11- A19-B11C33; C34; C35; C36; C37; C38;

A19-Bil- A19-Bll- A19-B11- A19-B11- A19-B11- A19-B11C39; C40; C41; C42; C43; C44;

A19-Bll- A19-Bi1- A20-B11-C1; A20-B11-C2; A20-B1l-C3; A20-B11-C4;

C45; C46;

A20-Bl1-C5; A20-B11-C6; A20-Bll-C7; A20-B11-C8; A20-B1l-C9; A20-B11C10;

A20-Bll- A20-B11- A20-B11- A20-B11- A20-Bl1- A20-B11Cll; C12; C13; C14; C15; C16;

A20-B11- A20-B11- A20-B11- A20-B11- A20-B11- A20-B11C17; C18; C19; C20; C21; C22;

A20-Bl1- A20-Bl1- A20-Bl1- A20-Bll- A20-B11- A20-Bl1C23; C24; C25; C26; C27; C28;

A20-B11- A20-Bll- A20-B11- A20-B11- A20-B11- A20-B1lC29; C30; C31; C32; C33; C34;

A20-B11- A20-B11- A20-B11- A20-B11- A20-Bl1- A20-B11C35; C36; C37; C38; C39; C40;

A20-B11- A20-B11- A20-Bl1- A20-B1l- A20-B11- A20-B11C41; C42; C43; C44; C45; C46;

A21-B11-C1; A21-B11-C2; A21-B11-C3; A21-B11-C4; A21-B11-C5; A21-B11-C6;

A21-Bll-C7; A21-B11-C8; A21-B11-C9; A21-Bi1- A21-B11- A21-Bil C10; Cll; C12;

A21-B1l- A21-B11- A21-B1l- A21-B11- A21-Bll- A21-B11C13; C14; C15; C16; C17; C18;

A21-B11- A21-Bll- A21-B11- A21-Bl1- A21-B11- A21-B11C19; C20; C21; C22; C23; C24;

A21-B11- A21-B11- A21-B11- A21-B11- A21-Bl1- A21-B11C25; C26; C27; C28; C29; C30;

A21-Bi1- A21-Bl1- A21-B11- A21-B11- A21-B11- A21-B11C31; C32; C33; C34; C35; C36;

A21-B11- A21-B11- A21-B11- A21-Bl1- A21-B11- A21-B11C37; C38; C39; C40; C41; C42;

A21-Bll- A21-B1l- A21-B11- A21-Bll- A22-B11-Cl; A22-B11-C2;

C43; C44; C45; C46;

A22-B1l-C3; A22-Bl1-C4; A22-Bll-C5; A22-Bll-C6; A22-Bll-C7; A22-Bll-CS;

A22-B11-C9; A22-B11- A22-Bll- A22-B11- A22-Bl1- A22-B11C10; C11; C12; C13; C14;

A22-B11- A22-B11- A22-B11- A22-B11- A22-Bll- A22-Bl1C15; C16; C17; C18; C19; C20;

A22-B11- A22-Bil- A22-B11- A22-Bll- A22-B11- A22-Bl1 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -84C21; C22; C23; C24; C25; C26;

A22-B11- A22-B11- A22-B11- A22-B11- A22-B11- A22-B11C27; C28; C29; C30; C31; C32;

A22-B11- A22-B11- A22-B11- A22-B11- A22-B11- A22-B11C33; C34; C35; C36; C37; C38;

A22-B11- A22-B11- A22-B11- A22-B11- A22-B11- A22-B11C39; C40; C41; C42; C43; C44;

A22-B11- A22-B11- A23-B11-C1; A23-B11-C2; A23-B11-C3; A23-B11-C4;

C45; C46;

A23-B11-C5; A23-B11-C6; A23-B11-C7; A23-B11-C8; A23-B11-C9; A23-B11C10;

A23-B11- A23-B11- A23-B11- A23-B11- A23-B11- A23-B11C11; C12; C13; C14; C15; C16;

A23-Bll- A23-B11- A23-B11- A23-B11- A23-B11- A23-B11C17; C18; C19; C20; C21; C22;

A23-Bil- A23-B11- A23-Bl1- A23-Bll- A23-B11- A23-B11C23; C24; C25; C26; C27; C28;

A23-B11- A23-B11- A23-B11- A23-Bil- A23-Bll- A23-B1lC29; C30; C31; C32; C33; C34;

A23-Bll- A23-Bl1- A23-B1l- A23-Bi1- A23-Bl1- A23-B11C35; C36; C37; C38; C39; - C40;

A23-Bli- A23-Bli- A23-B1l- A23-B11- A23-Bll- A23-B11C41; C42; C43; C44; C45; C46;

A24-B11-C1; A24-B11-C2; A24-Bli-C3; A24-B11-C4; A24-B11-C5; A24-Bll-C6;

A24-B11-C7; A24-B11-C8; A24-B11-C9; A24-B11- A24-B11- A24-B11 C10; C11; C12;

A24-B11- A24-B11- A24-B11- A24-Bll- A24-Bl1- A24-B1lC13; C14; C15; C16; C17; C18;

A24-B1l- A24-Bll- A24-B11- A24-B11- A24-B11- A24-Bl1C19; C20; C21; C22; C23; C24;

A24-B11- A24-B11- A24-B1l- A24-B11- A24-B11- A24-Bl1C25; C26; C27; C28; C29; C30;

A24-B1l- A24-Bl1- A24-Bll- A24-B1l- A24-B11- A24-B11C31; C32; C33; C34; C35; C36;

A24-Bll- A24-Bll- A24-Bll- A24-Bl1- A24-B11- A24-B1lC37; C38; C39; C40; C41; C42;

A24-B11- A24-B11- A24-Bll- A24-B11- A25-B11-C1; A25-Bli-C2;

C43; C44; C45; C46;

A25-Bli-C3; A25-Bl1-C4; A25-B11-C5; A25-B11-C6; A25-B11-C7; A25-B11-C8;

A25-B11-C9; A25-B11- A25-Bl1- A25-Bll- A25-Bll- A25-BllC10; Cll; C12; C13; C14;

A25-B11- A25-B11- A25-B11- A25-Bl1- A25-B11- A25-B1lC15; C16; C17; C18; C19; C20;

A25-B11- A25-Bll- A25-Bl1- A25-B11- A25-Bll- A25-B11C21; C22; C23; C24; C25; C26;

A25-B11- A25-B11- A25-B11- A25-Bl1- A25-B11- A25-B11C27; C28; C29; C30; C31; C32;

A25-Bll- A25-Bi1- A25-B11- A25-B11- A25-B11- A25-Bl1C33; C34; C35; C36; C37; C38;

A25-Bll- A25-B11- A25-B11- A25-Bll- A25-Bll- A25-B11C39; C40; C41; C42; C43; C44;

A25-B11- A25-B11- A26-B11-Cl; A26-B11-C2; A26-B11-C3; A26-Bl1-C4;

C45; C46;

A26-B11-C5; A26-Bll-C6; A26-Bit-C7; A26-B11-C8; A26-B11-C9; A26-Bll CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -85C10;

A26-B11- A26-B11- A26-B11- A26-B11- A26-B11- A26-B11Cli; C12; C13; C14; C15; C16;

A26-B11- A26-Bll- A26-B11- A26-B11- A26-B11- A26-Bl1C17; C18; C19; C20; C21; C22;

A26-Bll- A26-Bll- A26-Bi1- A26-Bll- A26-Bll- A26-BllC23; C24; C25; C26; C27; C28;

A26-Bil- A26-Bll- A26-B11- A26-Bl1- A26-Bii- A26-Bl1C29; C30; C31; C32; C33; C34;

A26-B11- A26-Bil- A26-Bl1- A26-B1l- A26-B11- A26-Bl1C35; C36; C37; C38; C39; C40;

A26-Bll- A26-Bl1- A26-B11- A26-Bll- A26-Bll- A26-B1lC41; C42; C43; C44; C45; C46;

A27-B11-Cl; A27-B11-C2; A27-B11-C3; A27-Bit-C4; A27-B11-C5; A27-Bit-C6;

A27-B11-C7; A27-Bli-C8; A27-Bit-C9; A27-B11- A27-B11- A27-Bil C10; Cli; C12;

A27-B11- A27-Bll- A27-B11- A27-B11- A27-Bil- A27-BliC13; C14; C15; C16; C17; C18;

A27-Bi1- A27-B11- A27-B11- A27-B11- A27-Bli- A27-Bi1C19; C20; C21; C22; C23; C24;

A27-B11- A27-B11- A27-B11- A27-Bli- A27-Bll- A27-B11C25; C26; C27; C28; C29; C30;

A27-Bil- A27-Bll- A27-Bli- A27-Bll- A27-B11- A27-Bl1C31; C32; C33; C34; C35; C36;

A27-B11- A27-Bll- A27-B1l- A27-B11- A27-B11- A27-BilC37; C38; C39; C40; C41; C42;

A27-B11- A27-B1l- A27-B11- A27-B11- A28-B11-C1; A28-Bit-C2;

C43; C44; C45; C46;

A28-B1I-C3; A28-B11-C4; A28-B11-C5; A28-B11-C6; A28-B11-C7; A28-B11-C8;

A28-B11-C9; A28-Bl1- A28-B11- A28-Bll- A28-B11- A28-B11C10; Cli; C12; C13; C14;

A28-Bll- A28-B11- A28-Bll- A28-Bll- A28-Bll- A28-B11C15; C16; C17; C18; C19; C20;

A28-B1l- A28-Bll- A28-Bll- A28-Bll- A28-Bll- A28-B11C21; C22; C23; C24; C25; C26;

A28-Bll- A28-Bll- A28-Bll- A28-Bll- A28-Bll- A28-BllC27; C28; C29; C30; C31; C32;

A28-Bll- A28-B11- A28-Bl1- A28-Bli- A28-Bll- A28-B11C33; C34; C35; C36; C37; C38;

A28-Bll- A28-B11- A28-B11- A28-B11- A28-Bi1- A28-B1lC39; C40; C41; C42; C43; C44;

A28-Bll- A28-B11- Al-B12-Cl; Al-B12-C2; Al-B12-C3; Ai-B12-C4;

C45; C46;

Al-B12-C5; A1-B12-C6; Al-B12-C7; Al-B12-C8; Al-B12-C9; Al-B12-C10;

Al-B12-Cll; Al-B12-C12; Al-B12-C13; Al-B12-C14; Al-B12-C15; Al-B12-C16;

Al-B12-C17; Al-B12-C18; Al-B12-CI9; Al-B12-C20; Al-B12-C21; Al-B12-C22;

Al-B12-C23; Al-B12-C24; Al-B12-C25; Al-B12-C26; Al-B12-C27; Al-B12-C28;

Al-B12-C29; Al-B12-C30; Ai-B12-C31; Al-B12-C32; Al-B12-C33; Al-B12-C34;

Al-B12-C35; Al-B12-C36; Al-B12-C37; Al-B12-C38; Al-B12-C39; Al-B12-C40;

Al-B12-C41; Al-B12-C42; Al-B12-C43; Al-B12-C44; Al-B12-C45; Al-B12-C46;

A2-B12-Cl; A2-B12-C2; A2-B12-C3; A2-B12-C4; A2-B12-C5; A2-B12-C6;

A2-B12-C7; A2-B12-C8; A2-B12-C9; A2-B12-C10; A2-B12-Ci1; A2-B12-C12;

A2-B12-C13; A2-B12-C14; A2-B12-C15; A2-B12-C16; A2-B12-C17; A2-B12-C18;

A2-B12-C19; A2-B12-C20; A2-B12-C21; A2-B12-C22; A2-B12-C23; A2-B12-C24;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -86A2-B12-C25; A2-B12-C26; A2-B12-C27; A2-B12-C28; A2-B12-C29; A2-B12-C30;

A2-B12-C31; A2-B12-C32; A2-B12-C33; A2-B12-C34; A2-B12-C35; A2-B12-C36;

A2-B12-C37; A2-B12-C38; A2-B12-C39; A2-B12-C40; A2-B12-C41; A2-B12-C42;

A2-B12-C43; A2-B12-C44; A2-B12-C45; A2-B12-C46; A3-B12-C1; A3-B12-C2;

A3-B12-C3; A3-B12-C4; A3-B12-C5; A3-B12-C6; A3-B12-C7; A3-B12-C8;

A3-B12-C9; A3-B12-C10; A3-B12-C11; A3-B12-C12; A3-B12-C13; A3-B12-C14;

A3-B12-C15; A3-B12-C16; A3-B12-C17; A3-B12-C18; A3-B12-C19; A3-B12-C20;

A3-B12-C21; A3-B12-C22; A3-B12-C23; A3-B12-C24; A3-B12-C25; A3-B12-C26;

A3-B12-C27; A3-B12-C28; A3-B12-C29; A3-B12-C30; A3-B12-C31; A3-B12-C32;

A3-B12-C33; A3-B12-C34; A3-B12-C35; A3-B12-C36; A3-B12-C37; A3-B12-C38;

A3-B12-C39; A3-B12-C40; A3-B12-C41; A3-B12-C42; A3-B12-C43; A3-B12-C44;

A3-B12-C45; A3-B12-C46; A4-B12-C1; A4-B12-C2; A4-B12-C3; A4-B12-C4;

A4-B12-C5; A4-B12-C6; A4-B12-C7; A4-B12-C8; A4-B12-C9; A4-B12-C10;

A4-B12-C11; A4-B12-C12; A4-B12-C13; A4-B12-C14; A4-B12-C15; A4-B12-C16;

A4-B12-C17; A4-B12-C18; A4-B12-C19; A4-B12-C20; A4-B12-C21; A4-B12-C22;

A4-B12-C23; A4-B12-C24; A4-B12-C25; A4-B12-C26; A4-B12-C27; A4-B12-C28;

A4-B12-C29; A4-B12-C30; A4-B12-C31; A4-B12-C32; A4-B12-C33; A4-B12-C34;

A4-B12-C35; A4-B12-C36; A4-B12-C37; A4-B12-C38; A4-B12-C39; A4-B12-C40;

A4-B12-C41; A4-B12-C42; A4-B12-C43; A4-B12-C44; A4-B12-C45; A4-B12-C46;

A5-B12-Cl; A5-B12-C2; A5-B12-C3; A5-B12-C4; A5-B12-C5; A5-B12-C6;

A5-B12-C7; A5-B12-C8; A5-B12-C9; A5-B12-C10; A5-B12-C11; A5-B12-C12;

A5-B12-C13; A5-B12-C14; A5-B12-C15; A5-B12-C16; A5-B12-C17; A5-B12-C18;

A5-B12-C19; A5-B12-C20; A5-B12-C21; A5-B12-C22; A5-B12-C23; A5-B12-C24;

A5-B12-C25; A5-B12-C26; A5-B12-C27; A5-B12-C28; A5-B12-C29; A5-B12-C30;

A5-B12-C31; A5-B12-C32; A5-B12-C33; A5-B12-C34; A5-B12-C35; A5-B12-C36;

A5-B12-C37; A5-B12-C38; A5-B12-C39; A5-B12-C40; A5-B12-C41; A5-B12-C42;

A5-B12-C43; A5-B12-C44; A5-B12-C45; A5-B12-C46; A6-B12-Cl; A6-B12-C2;

A6-B12-C3; A6-B12-C4; A6-B12-C5; A6-B12-C6; A6-B12-C7; A6-B12-C8;

A6-B12-C9; A6-B12-C10; A6-B12-C11; A6-B12-C12; A6-B12-C13; A6-B12-C14;

A6-B12-C15; A6-B12-C16; A6-B12-C17; A6-B12-C18; A6-B12-C19; A6-B12-C20;

A6-B12-C21; A6-B12-C22; A6-B12-C23; A6-B12-C24; A6-B12-C25; A6-B12-C26;

A6-B12-C27; A6-B12-C28; A6-B12-C29; A6-B12-C30; A6-B12-C31; A6-B12-C32;

A6-B12-C33; A6-B12-C34; A6-B12-C35; A6-B12-C36; A6-B12-C37; A6-B12-C38;

A6-B12-C39; A6-B12-C40; A6-B12-C41; A6-B12-C42; A6-B12-C43; A6-1312-C44;

A6-B12-C45; A6-B12-C46; A7-B12-Cl; A7-B12-C2; A7-B12-C3; A7-1112-C4;

A7-B12-C5; A7-B12-C6; A7-B12-C7; A7-B12-C8; A7-B12-C9; A7-B12-C10;

A7-B12-C11; A7-B12-C12; A7-B12-C13; A7-B12-C14; A7-B12-C15; A7-B12-C16;

A7-B12-C17; A7-B12-C18; A7-B12-C19; A7-B12-C20; A7-B12-C21; A7-B12-C22;

A7-B12-C23; A7-B12-C24; A7-B12-C25; A7-B12-C26; A7-B12-C27; A7-B12-C28;

A7-B12-C29; A7-B12-C30; A7-B12-C31; A7-B12-C32; A7-B12-C33; A7-B12-C34;

A7-B12-C35; A7-B12-C36; A7-B12-C37; A7-B12-C38; A7-B12-C39; A7-B12-C40;

A7-B12-C41; A7-B12-C42; A7-B12-C43; A7-B12-C44; A7-B12-C45; A7-B12-C46;

A8-B12-C1; A8-B12-C2; A8-B12-C3; A8-B12-C4; A8-B12-C5; A8-B12-C6;

A8-B12-C7; A8-B12-C8; A8-B12-C9; A8-B12-C10; A8-B12-Cll; A8-B12-C12;

A8-B12-C13; A8-B12-C14; A8-B12-C15; A8-B12-C16; A8-B12-C17; A8-B12-C18;

A8-B12-C19; A8-B12-C20; A8-B12-C21; A8-B12-C22; A8-B12-C23; A8-B12-C24;

A8-B12-C25; A8-B12-C26; A8-B12-C27; A8-B12-C28; A8-B12-C29; A8-B12-C30;

A8-B12-C31; A8-B12-C32; A8-B12-C33; A8-B12-C34; A8-B12-C35; A8-B12-C36;

A8-B12-C37; A8-B12-C38; A8-B12-C39; A8-B12-C40; A8-B12-C41; A8-B12-C42;

A8-B12-C43; A8-B12-C44; A8-B12-C45; A8-B12-C46; A9-B12-Cl; A9-B12-C2;

A9-B12-C3; A9-B12-C4; A9-B12-C5; A9-B12-C6; A9-B12-C7; A9-B12-C8;

A9-B12-C9; A9-B12-C10; A9-B12-C11; A9-B12-C12; A9-B12-C13; A9-B12-C14;

A9-B12-C15; A9-B12-C16; A9-B12-C17; A9-B12-C18; A9-B12-C19; A9-B12-C20;

A9-B12-C21; A9-B12-C22; A9-B12-C23; A9-B12-C24; A9-B12-C25; A9-B12-C26;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -87A9-B12-C27; A9-B12-C28; A9-B12-C29; A9-B12-C30; A9-B12-C31; A9-B12-C32;

A9-B12-C33; A9-B12-C34; A9-B12-C35; A9-B12-C36; A9-B12-C37; A9-B12-C38;

A9-B12-C39; A9-B12-C40; A9-B12-C41; A9-B12-C42; A9-B12-C43; A9-B12-C44;

A9-B12-C45; A9-B12-C46; A10-B12-C1; A10-B12-C2; A10-B12-C3; A10-B12-C4;

A10-B12-C5; A10-B12-C6; A10-B12-C7; A10-B12-C8; A10-B12-C9; A10-B12 C10;

A10-B12- A10-B12- A10-B12- A10-B12- A10-B12- A10-B12C11; C12; C13; C14; C15; C16;

A10-B12- A10-B12- A10-B12- A10-B12- A10-B12- A10-B12C17; CIS; C19; C20; C21; C22;

A10-B12- A10-B12- A10-B12- A10-B12- A10-B12- A10-B12C23; C24; C25; C26; C27; C28;

A10-B12- A10-B12- A10-B12- A10-B12- A10-B12- A10-B12C29; C30; C31; C32; C33; C34;

A10-B12- A10-B12- A10-B12- A10-B12- Al0-B12- A10-B12C35; C36; C37; C38; C39; C40;

A10-B12- A10-B12- A10-B12- A10-B12- A10-B12- A10-B12C41; C42; C43; C44; C45; C46;

All-B12-Cl; All-B12-C2; All-B12-C3; All-B12-C4; All-B12-C5; All-B12-C6;

All-B12-C7; All-B12-C8; All-B12-C9; All-B12- All-B12- All-B12 C10; Cl l; C12;

All-B12- All-B12- All-B12- All-B12- All-B12- All-B12C13; C14; C15; C16; C17; C18;

All-B12- All-B12- All-B12- All-B12- All-B12- All-B12C19; C20; C21; C22; C23; C24;

All-B12- All-B12- All-B12- All-B12- All-B12- All-B12C25; C26; C27; C28; C29; C30;

All-B12- All-B12- All-B12- All-B12- All-B12- All-B12C31; C32; C33; C34; C35; C36;

All-B12- All-B12- All-B12- All-B12- All-B12- All-B12C37; C38; C39; C40; C41; C42;

All-B12- All-B12- All-B12- All-B12- A12-B12-C1; A12-B12-C2;

C43; C44; C45; C46;

A12-B12-C3; A12-B12-C4; A12-B12-C5; A12-B12-C6; A12-B12-C7; A12-B12-C8;

A12-B12-C9; A12-B12- A12-B12- A12-B12- A12-B12- A12-B12C10; Cll; C12; C13; C14;

A12-B12- A12-B12- A12-B12- A12-B12- A12-B12- A12-B12C15; C16; C17; C18; C19; C20;

A12-B12- A12-B12- A12-B12- A12-B12- A12-B12- A12-B12C21; C22; C23; C24; C25; C26;

A12-B12- A12-B12- A12-B12- A12-B12- A12-B12- A12-B12C27; C28; C29; C30; C31; C32;

A12-B12- A12-B12- A12-B12- A12-B12- A12-B12- A12-B12C33; C34; C35; C36; C37; C38;

A12-B12- A12-B12- A12-B12- A12-B12- A12-B12- A12-B12C39; C40; C41; C42; C43; C44;

A12-B12- A12-B12- A13-B12-C1; A13-B12-C2; A13-B12-C3; A13-B12-C4;

C45; C46;

A13-B12-C5; A13-B12-C6; A13-B12-C7; A13-B12-C8; A13-B12-C9; A13-B12C10;

A13-B12- A13-B12- A13-B12- A13-B12- A13-B12- A13-B12C11; C12; C13; C14; C15; C16;

A13-B12- A13-B12- A13-B12- A13-B12- A13-B12- A13-B12C17; C18; C19; C20; C21; C22;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -88A13-B12- A13-B12- A13-B12- A13-B12- A13-B12- A13-B12C23; C24; C25; C26; C27; C28;

A13-B12- A13-B12- A13-B12- A13-B12- A13-B12- A13-B12C29; C30; C31; C32; C33; C34;

A13-B12- A13-B12- A13-B12- A13-B12- A13-B12- A13-B12C35; C36; C37; C38; C39; C40;

A13-B12- A13-B12- A13-B12- A13-B12- A13-B12- A13-B12C41; C42; C43; C44; C45; C46;

A14-B12-C1; A14-B12-C2; A14-B12-C3; A14-B12-C4; A14-B12-C5; A14-B12-C6;

A14-B12-C7; A14-B12-C8; A14-B12-C9; A14-B12- A14-B12- A14-B12 C10; Cll; C12;

A14-B12- A14-B12- A14-B12- A14-B12- A14-B12- A14-B12C13; C14; C15; C16; C17; C18;

A14-B12- A14-B12- A14-B12- A14-B12- A14-B12- A14-B12C19; C20; C21; C22; C23; C24;

A14-B12- A14-B12- A14-B12- A14-B12- A14-B12- A14-B12C25; C26; C27; C28; C29; C30;

A14-B12- A14-B12- A14-B12- A14-B12- A14-B12- A14-B12C31; C32; C33; C34; C35; C36;

A14-B12- A14-B12- A14-B12- A14-B12- A14-B12- A14-B12C37; C38; C39; C40; C41; C42;

A14-B12- A14-B12- A14-B12- A14-B12- A15-B12-C1; A15-B12-C2;

C43; C44; C45; C46;

A15-B12-C3; A15-B12-C4; A15-B12-C5; A15-B12-C6; A15-B12-C7; A15-B12-C8;

A15-B12-C9; A15-B12- A15-B12- A15-B12- A15-B12- A15-B12C10; Cil; C12; C13; C14;

A15-B12- A15-B12- A15-B12- A15-B12- A15-B12- A15-B12C15; C16; C17; C18; C19; C20;

A15-B12- A15-B12- A15-B12- A15-B12- A15-B12- A15-B12C21; C22; C23; C24; C25; C26;

A15-B12- A15-B12- A15-B12- A15-B12- A15-B12- A15-B12C27; C28; C29; C30; C31; C32;

A15-B12- A15-B12- A15-B12- A15-B12- A15-B12- A15-B12C33; C34; C35; C36; C37; C38;

A15-B12- A15-B12- A15-B12- A15-B12- A15-B12- A15-B12C39; C40; C41; C42; C43; C44;

A15-B12- A15-B12- A16-B12-Cl; A16-B12-C2; A16-B12-C3; A16-B12-C4;

C45; C46;

A16-B12-C5; A16-B12-C6; A16-B12-C7; A16-B12-C8; A16-B12-C9; A16-B12C10;

A16-B12- A16-B12- A16-B12- A16-B12- A16-B12- A16-B12Cil; C12; C13; C14; C15; C16;

A16-B12- A16-B12- A16-B12- A16-B12- A16-B12- A16-B12C17; C18; C19; C20; C21; C22;

A16-B12- A16-B12- A16-B12- A16-B12- A16-B12- A16-B12C23; C24; C25; C26; C27; C28;

A16-B12- A16-B12- A16-B12- A16-B12- A16-B12- A16-B12C29; C30; C31; C32; C33; C34;

A16-B12- A16-B12- A16-B12- A16-B12- A16-B12- A16-B12C35; C36; C37; C38; C39; C40;

A16-B12- A16-B12- A16-B12- A16-B12- A16-B12- A16-B12C41; C42; C43; C44; C45; C46;

A17-B12-C1; A17-B12-C2; A17-B12-C3; A17-B12-C4; A17-B12-C5; A17-B12-C6;

A17-B12-C7; A17-B12-C8; A17-B12-C9; A17-B12- A17-B12- A17-B12 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -89C10; Cll; C12;

A17-B12- A17-B12- A17-B12- A17-B12- A17-B12- A17-B12C13; C14; C15; C16; C17; C18;

A17-B12- A17-B12- A17-B12- A17-B12- A17-B12- A17-B12C19; C20; C21; C22; C23; C24;

A17-B12- A17-B12- A17-B12- A17-B12- A17-B12- A17-B12C25; C26; C27; C28; C29; C30;

A17-B12- A17-B12- A17-B12- A17-B12- A17-B12- A17-B12C31; C32; C33; C34; C35; C36;

A17-B12- A17-B12- A17-B12- A17-B12- A17-B12- A17-B12C37; C38; C39; C40; C41; C42;

A17-B12- A17-B12- A17-B12- A17-B12- A18-B12-Cl; A18-B12-C2;

C43; C44; C45; C46;

A18-B12-C3; A18-B12-C4; A18-B12-C5; A18-B12-C6; A18-B12-C7; A18-B12-C8;

A18-B12-C9; A18-B12- A18-B12- A18-B12- A18-B12- A18-B12C10; C11; C12; C13; C14;

A18-B12- A18-B12- A1S-B12- A18-B12- A18-B12- A18-B12C15; C16; C17; C18; C19; C20;

A18-B12- A18-B12- A18-B12- A18-B12- A18-B12- A18-B12C21; C22; C23; C24; C25; C26;

A18-B12- A18-B12- A18-B12- A18-B12- A18-B12- A18-B12C27; C28; C29; C30; C31; C32;

A18-B12- A18-B12- A18-B12- A18-B12- A18-B12- A18-B12C33; C34; C35; C36; C37; C38;

A18-B12- A18-B12- A18-B12- A18-B12- A18-B12- A18-B12C39; C40; C41; C42; C43; C44;

A18-B12- A18-B12- A19-B12-Cl; A19-B12-C2; A19-B12-C3; A19-B12-C4;

C45; C46;

A19-B12-C5; A19-B12-C6; A19-B12-C7; A19-B12-C8; A19-B12-C9; A19-B12C10;

A19-B12- A19-B12- A19-B12- A19-B12- A19-B12- A19-B12Cll; C12; C13; C14; C15; C16;

A19-B12- A19-B12- A19-B12- A19-B12- A19-B12- A19-B12C17; C18; C19; C20; C21; C22;

A19-B12- A19-B12- A19-B12- A19-B12- A19-B12- A19-B12C23; C24; C25; C26; C27; C28;

A19-B12- A19-B12- A19-B12- A19-B12- A19-B12- A19-B12C29; C30; C31; C32; C33; C34;

A19-B12- A19-B12- A19-B12- A19-B12- A19-B12- A19-B12C35; C36; C37; C38; C39; C40;

A19-B12- A19-B12- A19-B12- A19-B12- A19-B12- A19-B12C41; C42; C43; C44; C45; C46;

A20-B12-C1; A20-B12-C2; A20-B12-C3; A20-B12-C4; A20-B12-C5; A20-B12-C6;

A20-B12-C7; A20-B12-C8; A20-B12-C9; A20-B12- A20-B12- A20-B12 C10; C11; C12;

A20-B12- A20-B12- A20-B12- A20-B12- A20-B12- A20-B12C13; C14; C15; C16; C17; C18;

A20-B12- A20-B12- A20-B12- A20-B12- A20-B12- A20-B12C19; C20; C21; C22; C23; C24;

A20-B12- A20-B12- A20-B12- A20-B12- A20-B12- A20-B12C25; C26; C27; C28; C29; C30;

A20-B12- A20-B12- A20-B12- A20-B12- A20-B12- A20-B12C31; C32; C33; C34; C35; C36;

A20-B12- A20-B12- A20-B12- A20-B12- A20-B12- A20-B12 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -90C37; C38; C39; C40; C41; C42;

A20-B12- A20-B12- A20-B12- A20-B12- A21-B12-Cl; A21-B12-C2;

C43; C44; C45; C46;

A21-B12-C3; A21-B12-C4; A21-B12-C5; A21-B12-C6; A21-B12-C7; A21-B12-C8;

A21-B12-C9; A21-B12- A21-B12- A21-B12- A21-B12- A21-B12C10; Cll; C12; C13; C14;

A21-B12- A21-B12- A21-B12- A21-B12- A21-B12- A21-B12C15; C16; C17; C18; C19; C20;

A21-B12- A21-B12- A21-B12- A21-B12- A21-B12- A21-B12C21; C22; C23; C24; C25; C26;

A21-B12- A21-B12- A21-B12- A21-B12- A21-B12- A21-B12C27; C28; C29; C30; C31; C32;

A21-B12- A21-B12- A21-B12- A21-B12- A21-B12- A21-B12C33; C34; C35; C36; C37; C38;

A21-B12- A21-B12- A21-B12- A21-B12- A21-B12- A21-B12C39; C40; C41; C42; C43; C44;

A21-B12- A21-B12- A22-B12-CI; A22-B12-C2; A22-B12-C3; A22-B12-C4;

C45; C46;

A22-B12-C5; A22-B12-C6; A22-B12-C7; A22-B12-C8; A22-B12-C9; A22-B12C10;

A22-B12- A22-B12- A22-B12- A22-B12- A22-B12- A22-B12Cll; C12; C13; C14; C15; C16;

A22-B12- A22-B12- A22-B12- A22-B12- A22-B12- A22-B12C17; C18; C19; C20; C21; C22;

A22-B12- A22-B12- A22-B12- A22-B12- A22-B12- A22-B12C23; C24; C25; C26; C27; C28;

A22-B12- A22-B12- A22-B12- A22-B12- A22-B12- A22-B12C29; C30; C31; C32; C33; C34;

A22-B12- A22-B12- A22-B12- A22-B12- A22-B12- A22-B12C35; C36; C37; C38; C39; C40;

A22-B12- A22-B12- A22-B12- A22-B12- A22-B12- A22-B12C41; C42; C43; C44; C45; C46;

A23-B12-C1; A23-B12-C2; A23-B12-C3; A23-B12-C4; A23-B12-C5; A23-B12-C6;

A23-B12-C7; A23-B12-C8; A23-B12-C9; A23-B12- A23-B12- A23-B12 C10; Cll; C12;

A23-B12- A23-B12- A23-B12- A23-B12- A23-B12- A23-B12C13; C14; C15; C16; C17; C18;

A23-B12- A23-B12- A23-B12- A23-B12- A23-B12- A23-B12C19; C20; C21; C22; C23; C24;

A23-B12- A23-B12- A23-B12- A23-B12- A23-B12- A23-B12C25; C26; C27; C28; C29; C30;

A23-B12- A23-B12- A23-B12- A23-B12- A23-B12- A23-B12C31; C32; C33; C34; C35; C36;

A23-B12- A23-B12- A23-B12- A23-B12- A23-B12- A23-B12C37; C38; C39; C40; C41; C42;

A23-B12- A23-B12- A23-B12- A23-B12- A24-B12-CI; A24-B12-C2;

C43; C44; C45; C46;

A24-B12-C3; A24-B12-C4; A24-B12-C5; A24-B12-C6; A24-B12-C7; A24-B12-C8;

A24-B12-C9; A24-B12- A24-B12- A24-B12- A24-B12- A24-B12C10; Cll; C12; C13; C14;

A24-B12- A24-B12- A24-B12- A24-B12- A24-B12- A24-B12C15; C16; C17; C18; C19; C20;

A24-B12- A24-1112- A24-B12- A24-B12- A24-B12- A24-B12C21; C22; C23; C24; C25; C26;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -91A24-B12- A24-B12- A24-B12- A24-B12- A24-B12- A24-B12C27; C28; C29; C30; C31; C32;

A24-B12- A24-B12- A24-B12- A24-B12- A24-B12- A24-B12C33; C34; C35; C36; C37; C38;

A24-B12- A24-B12- A24-B12- A24-B12- A24-B12- A24-B12C39; C40; C41; C42; C43; C44;

A24-B12- A24-B12- A25-B12-C1; A25-B12-C2; A25-B12-C3; A25-B12-C4;

C45; C46;

A25-B12-C5; A25-B12-C6; A25-B12-C7; A25-B12-C8; A25-B12-C9; A25-B12C10;

A25-B12- A25-B12- A25-B12- A25-B12- A25-B12- A25-B12C11; C12; C13; C14; C15; C16;

A25-B12- A25-B12- A25-B12- A25-B12- A25-B12- A25-B12C17; C18; C19; C20; C21; C22;

A25-B12- A25-B12- A25-B12- A25-B12- A25-B12- A25-B12C23; C24; C25; C26; C27; C28;

A25-B12- A25-B12- A25-B12- A25-B12- A25-B12- A25-B12C29; C30; C31; C32; C33; C34;

A25-B12- A25-B12- A25-B12- A25-B12- A25-B12- A25-B12C35; C36; C37; C38; C39; C40;

A25-B12- A25-B12- A25-B12- A25-B12- A25-B12- A25-B12C41; C42; C43; C44; C45; C46;

A26-B12-CI; A26-B12-C2; A26-B12-C3; A26-B12-C4; A26-B12-C5; A26-B12-C6;

A26-B12-C7; A26-B12-C8; A26-B12-C9; A26-B12- A26-B12- A26-B12 C10; Cll; C12;

A26-B12- A26-B12- A26-B12- A26-B12- A26-B12- A26-B12C13; C14; C15; C16; C17; C18;

A26-B12- A26-B12- A26-B12- A26-B12- A26-B12- A26-B12C19; C20; C21; C22; C23; C24;

A26-B12- A26-B12- A26-B12- A26-B12- A26-B12- A26-B12C25; C26; C27; C28; C29; C30;

A26-B12- A26-B12- A26-B12- A26-B12- A26-B12- A26-B12C31; C32; C33; C34; C35; C36;

A26-B12- A26-B12- A26-B12- A26-B12- A26-B12- A26-B12C37; C38; C39; C40; C41; C42;

A26-B12- A26-B12- A26-B12- A26-B12- A27-B12-C1; A27-B12-C2;

C43; C44; C45; C46;

A27-B12-C3; A27-B12-C4; A27-B12-C5; A27-B12-C6; A27-B12-C7; A27-B12-C8;

A27-B12-C9; A27-B12- A27-B12- A27-B12- A27-B12- A27-B12C10; Cli; C12; C13; C14;

A27-B12- A27-B12- A27-B12- A27-B12- A27-B12- A27-B12C15; C16; C17; C18; C19; C20;

A27-B12- A27-B12- A27-B12- A27-B12- A27-B12- A27-B12C21; C22; C23; C24; C25; C26;

A27-B12- A27-B12- A27-B12- A27-B12- A27-B12- A27-B12C27; C28; C29; C30; C31; C32;

A27-B12- A27-B12- A27-B12- A27-B12- A27-B12- A27-B12C33; C34; C35; C36; C37; C38;

A27-B12- A27-B12- A27-B12- A27-B12- A27-B12- A27-B12C39; C40; C41; C42; C43; C44;

A27-B12- A27-B12- A28-B12-Cl; A28-B12-C2; A28-B12-C3; A28-B12-C4;

C45; C46;

A28-B12-C5; A28-B12-C6; A28-B12-C7; A28-B12-C8; A28-B12-C9; A28-B12C10;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -92A28-B12- A28-B12- A28-B12- A28-B12- A28-B12- A28-B12C11; C12; C13; C14; C15; C16;

A28-B12- A28-B12- A28-B12- A28-B12- A28-B12- A28-B12C17; C18; C19; C20; C21; C22;

A28-B12- A28-B12- A28-B12- A28-B12- A28-B12- A28-B12C23; C24; C25; C26; C27; C28;

A28-B12- A28-B12- A28-B12- A28-B12- A28-B12- A28-B12C29; C30; C31; C32; C33; C34;

A28-B12- A28-B12- A28-B12- A28-B12- A28-B12- A28-B12C35; C36; C37; C38; C39; C40;

A28-B12- A28-B12- A28-B12- A28-B12- A28-B12- A28-B12C41; C42; C43; C44; C45; C46;

Al-B13-Ci; Al-B13-C2; Al-B13-C3; Al-B13-C4; Al-B13-C5; Al-B13-C6;

Al-B13-C7; Al-B13-C8; Al-B13-C9; Al-B13-C10; Al-B13-C11; Al-B13-C12;

Al-B13-C13; Al-B13-C14; Al-B13-C15; Ai-B13-C16; Al-B13-C17; A1-B13-C18;

Ai-B13-C19; Al-B13-C20; Al-B13-C21; Al-B13-C22; Al-B13-C23; Al-B13-C24;

Al-B13-C25; Al-B13-C26; Al-B13-C27; Al-B13-C28; Al-B13-C29; Al-B13-C30;

Al-B13-C31; Al-B13-C32; Al-B13-C33; Al-B13-C34; Ai-B13-C35; Al-B13-C36;

Al-B13-C37; Al-B13-C38; Al-B13-C39; Al-B13-C40; Al-B13-C41; Al-B13-C42;

Al-B13-C43; Al-B13-C44; Al-B13-C45; Al-B13-C46; A2-B13-C1; A2-B13-C2;

A2-B13-C3; A2-B13-C4; A2-B13-C5; A2-B13-C6; A2-B13-C7; A2-B13-C8;

A2-B13-C9; A2-B13-C10; A2-B13-Cll; A2-B13-C12; A2-B13-C13; A2-B13-C14;

A2-B13-C15; A2-B13-C16; A2-B13-C17; A2-B13-C18; A2-B13-C19; A2-B13-C20;

A2-B13-C21; A2-B13-C22; A2-B13-C23; A2-B13-C24; A2-B13-C25; A2-B13-C26;

A2-B13-C27; A2-B13-C28; A2-B13-C29; A2-B13-C30; A2-B13-C31; A2-B13-C32;

A2-B13-C33; A2-B13-C34; A2-B13-C35; A2-B13-C36; A2-B13-C37; A2-B13-C38;

A2-B13-C39; A2-B13-C40; A2-B13-C41; A2-B13-C42; A2-B13-C43; A2-B13-C44;

A2-B13-C45; A2-B13-C46; A3-B13-C1; A3-B13-C2; A3-B13-C3; A3-B13-C4;

A3-B13-C5; A3-B13-C6; A3-B13-C7; A3-B13-C8; A3-B13-C9; A3-B13-C10;

A3-B13-Cl1; A3-B13-C12; A3-B13-C13; A3-B13-C14; A3-B13-C15; A3-B13-C16;

A3-B13-C17; A3-B13-C18; A3-B13-C19; A3-B13-C20; A3-B13-C21; A3-B13-C22;

A3-B13-C23; A3-B13-C24; A3-B13-C25; A3-B13-C26; A3-B13-C27; A3-B13-C28;

A3-B13-C29; A3-B13-C30; A3-B13-C31; A3-B13-C32; A3-B13-C33; A3-B13-C34;

A3-B13-C35; A3-B13-C36; A3-B13-C37; A3-B13-C38; A3-B13-C39; A3-B13-C40;

A3-B13-C41; A3-B13-C42; A3-B13-C43; A3-B13-C44; A3-B13-C45; A3-B13-C46;

A4-B13-C1; A4-B13-C2; A4-B13-C3; A4-B13-C4; A4-B13-C5; A4-B13-C6;

A4-B13-C7; A4-B13-C8; A4-B13-C9; A4-B13-C10; A4-B13-C11; A4-B13-C12;

A4-B13-C13; A4-B13-C14; A4-B13-C15; A4-B13-C16; A4-B13-C17; A4-B13-C18;

A4-B13-C19; A4-B13-C20; A4-B13-C21; A4-B13-C22; A4-B13-C23; A4-B13-C24;

A4-B13-C25; A4-B13-C26; A4-B13-C27; A4-B13-C28; A4-B13-C29; A4-B13-C30;

A4-B13-C31; A4-B13-C32; A4-B13-C33; A4-B13-C34; A4-B13-C35; A4-B13-C36;

A4-B13-C37; A4-B13-C38; A4-B13-C39; A4-B13-C40; A4-B13-C41; A4-B13-C42;

A4-B13-C43; A4-B13-C44; A4-B13-C45; A4-B13-C46; A5-B13-C1; A5-B13-C2;

A5-B13-C3; A5-B13-C4; A5-B13-C5; A5-B13-C6; A5-B13-C7; A5-B13-C8;

A5-B13-C9; A5-B13-ClO; A5-B13-C11; A5-B13-C12; A5-B13-C13; A5-B13-C14;

A5-B13-C15; A5-B13-C16; A5-Bi3-C17; A5-B13-C18; A5-B13-C19; A5-B13-C20;

A5-B13-C21; A5-B13-C22; A5-B13-C23; A5-B13-C24; A5-B13-C25; A5-B13-C26;

A5-B13-C27; A5-B13-C28; A5-B13-C29; A5-B13-C30; A5-B13-C31; A5-B13-C32;

A5-B13-C33; A5-B13-C34; A5-B13-C35; A5-B13-C36; A5-B13-C37; A5-B13-C38;

A5-B13-C39; A5-B13-C40; A5-B13-C41; A5-B13-C42; A5-B13-C43; A5-B13-C44;

A5-B13-C45; A5-B13-C46; A6-B13-Ci; A6-B13-C2; A6-B13-C3; A6-B13-C4;

A6-B13-C5; A6-B13-C6; A6-B13-C7; A6-B13-C8; A6-B13-C9; A6-B13-C10;

A6-B13-Cll; A6-B13-C12; A6-B13-C13; A6-B13-C14; A6-B13-C15; A6-B13-C16;

A6-B13-C17; A6-B13-C18; A6-B13-C19; A6-B13-C20; A6-B13-C21; A6-B13-C22;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -93A6-B13-C23; A6-B13-C24; A6-B13-C25; A6-B13-C26; A6-B13-C27; A6-B13-C28;

A6-B13-C29; A6-B13-C30; A6-B13-C31; A6-B13-C32; A6-B13-C33; A6-B13-C34;

A6-B13-C35; A6-B13-C36; A6-B13-C37; A6-B13-C38; A6-B13-C39; A6-B13-C40;

A6-B13-C41; A6-B13-C42; A6-B13-C43; A6-B13-C44; A6-B13-C45; A6-B13-C46;

A7-B13-Cl; A7-B13-C2; A7-B13-C3; A7-B13-C4; A7-B13-C5; A7-B13-C6;

A7-B13-C7; A7-B13-C8; A7-B13-C9; A7-B13-C10; A7-B13-C11; A7-B13-C12;

A7-B13-C13; A7-B13-C14; A7-B13-C15; A7-B13-C16; A7-B13-C17; A7-B13-C18;

A7-B13-C19; A7-B13-C20; A7-B13-C21; A7-B13-C22; A7-B13-C23; A7-B13-C24;

A7-B13-C25; A7-B13-C26; A7-B13-C27; A7-B13-C28; A7-B13-C29; A7-B13-C30;

A7-B13-C31; A7-B13-C32; A7-B13-C33; A7-B13-C34; A7-B13-C35; A7-B13-C36;

A7-B13-C37; A7-B13-C38; A7-B13-C39; A7-B13-C40; A7-B13-C41; A7-B13-C42;

A7-B13-C43; A7-B13-C44; A7-B13-C45; A7-B13-C46; A8-B13-Cl; A8-B13-C2;

A8-B13-C3; A8-B13-C4; A8-B13-C5; A8-B13-C6; A8-B13-C7; A8-B13-C8;

A8-B13-C9; A8-B13-C10; A8-B13-C11; A8-B13-C12; A8-B13-C13; A8-B13-C14;

A8-B13-C15; A8-B13-C16; A8-B13-C17; A8-B13-C18; A8-B13-C19; A8-B13-C20;

A8-B13-C21; A8-B13-C22; A8-B13-C23; A8-B13-C24; A8-B13-C25; A8-B13-C26;

A8-B13-C27; A8-B13-C28; A8-B13-C29; A8-B13-C30; A8-B13-C31; A8-B13-C32;

A8-B13-C33; A8-B13-C34; A8-B13-C35; A8-B13-C36; A8-B13-C37; A8-B13-C38;

A8-B13-C39; A8-B13-C40; A8-B13-C41; A8-B13-C42; A8-B13-C43; A8-B13-C44;

A8-B13-C45; A8-B13-C46; A9-B13-C1; A9-B13-C2; A9-B13-C3; A9-B13-C4;

A9-B13-C5; A9-B13-C6; A9-B13-C7; A9-B13-C8; A9-B13-C9; A9-B13-C10;

A9-B13-C11; A9-B13-C12; A9-B13-C13; A9-B13-C14; A9-B13-C15; A9-B13-C16;

A9-B13-C17; A9-B13-C18; A9-B13-C19; A9-B13-C20; A9-B13-C21; A9-B13-C22;

A9-B13-C23; A9-B13-C24; A9-B13-C25; A9-B13-C26; A9-B13-C27; A9-B13-C28;

A9-B13-C29; A9-B13-C30; A9-B13-C31; A9-B13-C32; A9-B13-C33; A9-B13-C34;

A9-B13-C35; A9-B13-C36; A9-B13-C37; A9-B13-C38; A9-B13-C39; A9-B13-C40;

A9-B13-C41; A9-B13-C42; A9-B13-C43; A9-B13-C44; A9-B13-C45; A9-B13-C46;

A10-B13-C1; A10-B13-C2; A10-B13-C3; A10-B13-C4; A10-B13-C5; A10-B13-C6;

A10-B13-C7; A10-B13-C8; A10-B13-C9; A10-B13- A10-B13- A10-B13 C10; Cli; C12;

A10-B13- A10-B13- A10-B13- A10-B13- A10-B13- A10-B13C13; C14; C15; C16; C17; C18;

A10-B13- A10-B13- A10-B13- A10-B13- A10-B13- A10-B13C19; C20; C21; C22; C23; C24;

A10-B13- A10-B13- A10-B13- A10-B13- A10-B13- Al0-B13C25; C26; C27; C28; C29; C30;

A10-B13- A10-B13- A10-B13- A10-B13- A10-B13- A10-B13C31; C32; C33; C34; C35; C36;

A10-B13.- A10-B13- A10-B13- A10-B13- A10-B13- A10-B13C37; C38; C39; C40; C41; C42;

A10-B13- A10-B13- A10-B13- A10-B13- Ali-B13-Cl; All-B13-C2;

C43; C44; C45; C46;

All-B13-C3; All-B13-C4; All-B13-C5; All-B13-C6; All-B13-C7; Ali-B13-C8;

All-B13-C9; All-B13- All-B13- All-B13- All-B13- Ail-B13C10; Cll; C12; C13; C14;

All-B13- All-B13- All-B13- All-B13- All-B13- All-B13C15; C16; C17; C18; C19; C20;

All-B13- All-B13- All-B13- All-B13- All-B13- All-B13C21; C22; C23; C24; C25; C26;

All-B13- All-B13- All-B13- All-B13- Ali-B13- All-B13C27; C28; C29; C30; C31; C32;

All-B13- All-B13- All-B13- All-B13- All-B13- All-B13C33; C34; C35; C36; C37; C38;

All-B13- All-B13- All-B13- Ali-B13- All-B13- All-B13 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -94C39; C40; C41; C42; C43; C44;

All-B13- All-B13- A12-B13-Cl; A12-B13-C2; A12-B13-C3; A12-B13-C4;

C45; C46;

A12-B13-C5; A12-B13-C6; A12-B13-C7; A12-B13-C8; A12-B13-C9; A12-B13C10;

A12-B13- A12-B13- A12-B13- A12-B13- A12-B13- A12-B13Cli; C12; C13; C14; C15; C16;

A12-B13- A12-B13- A12-B13- A12-B13- A12-B13- A12-B13C17; C18; C19; C20; C21; C22;

A12-B13- A12-B13- A12-B13- A12-B13- A12-B13- A12-B13C23; C24; C25; C26; C27; C28;

A12-B13- A12-B13- A12-B13- A12-B13- A12-B13- A12-B13C29; C30; C31; C32; C33; C34;

A12-B13- A12-B13- A12-B13- A12-B13- A12-B13- A12-B13C35; C36; C37; C38; C39; C40;

A12-B13- A12-B13- A12-B13- A12-B13- A12-B13- A12-B13C41; C42; C43; C44; C45; C46;

A13-B13-Cl; A13-B13-C2; A13-B13-C3; A13-B13-C4; A13-B13-C5; A13-B13-C6;

A13-B13-C7; A13-B13-C8; A13-B13-C9; A13-B13- A13-B13- A13-B13 C10; C11; C12;

A13-Bi3- A13-B13- A13-B13- A13-B13- A13-B13- A13-B13C13; C14; C15; C16; C17; C18;

A13-Bi3- A13-B13- A13-B13- A13-Bi3- A13-B13- A13-B13C19; C20; C21; C22; C23; C24;

A13-B13- A13-B13- A13-B13- A13-B13- A13-B13- A13-B13C25; C26; C27; C28; C29; C30;

A13-B13- A13-B13- A13-B13- A13-Bi3- A13-B13- A13-B13C31; C32; C33; C34; C35; C36;

A13-B13- A13-B13- A13-B13- A13-B13- A13-B13- A13-B13C37; C38; C39; C40; C41; C42;

A13-Bi3- A13-B13- A13-B13- A13-B13- A14-B13-C1; A14-B13-C2;

C43; C44; C45; C46;

A14-B13-C3; A14-B13-C4; A14-B13-C5; A14-B13-C6; A14-B13-C7; A14-B13-C8;

A14-B13-C9; A14-B13- A14-B13- A14-B13- A14-B13- A14-B13C10; Cll; C12; C13; C14;

A14-B13- A14-Bi3- A14-B13- A14-B13- A14-B13- A14-B13C15; C16; C17; C18; C19; C20;

A14-B13- A14-Bi3- A14-Bi3- A14-B13- A14-B13- A14-B13C21; C22; C23; C24; C25; C26;

A14-Bi3- A14-Bi3- A14-B13- A14-B13- A14-B13- A14-B13C27; C28; C29; C30; C31; C32;

A14-B13- A14-B13- A14-B13- A14-B13- A14-B13- A14-B13C33; C34; C35; C36; C37; C38;

A14-B13- A14-B13- A14-B13- A14-B13- A14-B13- A14-B13C39; C40; C41; C42; C43; C44;

A14-B13- A14-Bi3- A15-B13-C1; A15-B13-C2; A15-Bi3-C3; A15-Bi3-C4;

C45; C46;

A15-Bi3-C5; A15-B13-C6; A15-B13-C7; A15-B13-CS; A15-Bi3-C9; A15-B13C10;

A15-B13- A15-Bi3- A15-B13- A15-B13- A15-B13- A15-B13Cil; C12; C13; C14; C15; C16;

A15-B13- A15-B13- A15-Bi3- A15-B13- A15-B13- A15-B13C17; C18; C19; C20; C21; C22;

A15-B13- A15-B13- A15-B13- A15-B13- A15-B13- A15-B13 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -95C23; C24; C25; C26; C27; C28;

A15-B13- A15-B13- A15-B13- A15-B13- A15-B13- A15-B13C29; C30; C31; C32; C33; C34;

A15-B13- A15-B13- A15-B13- A15-B13- A15-B13- A15-B13C35; C36; C37; C38; C39; C40;

A15-B13- A15-B13- A15-B13- A15-B13- A15-B13- A15-B13C41; C42; C43; C44; C45; C46;

A16-B13-Cl; A16-B13-C2; A16-B13-C3; A16-B13-C4; A16-B13-C5; A16-B13-C6;

A16-B13-C7; A16-B13-C8; A16-B13-C9; A16-B13- A16-B13- A16-B13 C10; Cll; C12;

A16-B13- A16-B13- A16-B13- A16-B13- A16-B13- A16-B13C13; C14; C15; C16; C17; C18;

A16-B13- A16-B13- A16-B13- A16-B13- A16-B13- A16-B13C19; C20; C21; C22; C23; C24;

A16-B13- A16-B13- A16-B13- A16-B13- A16-B13- A16-B13C25; C26; C27; C28; C29; C30;

A16-B13- A16-B13- A16-B13- A16-B13- A16-B13- A16-B13C31; C32; C33; C34; C35; C36;

A16-B13- A16-B13- A16-B13- A16-1313- A16-B13- A16-B13C37; C38; C39; C40; C41; C42;

A16-B13- A16-B13- A16-B13- A16-B13- A17-B13-C1; A17-B13-C2;

C43; C44; C45; C46;

A17-B13-C3; A17-B13-C4; A17-B13-C5; A17-B13-C6; A17-B13-C7; A17-B13-C8;

A17-B13-C9; A17-B13- A17-B13- A17-B13- A17-B13- A17-B13C10; Cll; C12; C13; C14;

A17-B13- A17-B13- A17-B13- A17-B13- A17-B13- A17-B13C15; C16; C17; C18; C19; C20;

A17-B13- A17-B13- A17-B13- A17-B13- A17-B13- A17-B13C21; C22; C23; C24; C25; C26;

A17-B13- A17-B13- A17-B13- A17-B13- A17-B13- A17-B13C27; C28; C29; C30; C31; C32;

A17-B13- A17-B13- A17-B13- A17-B13- A17-B13- A17-B13C33; C34; C35; C36; C37; C38;

A17-B13- A17-B13- A17-B13- A17-B13- A17-B13- A17-B13C39; C40; C41; C42; C43; C44;

A17-B13- A17-B13- A18-B13-Cl; A18-B13-C2; A18-B13-C3; A18-B13-C4;

C45; C46;

A18-B13-C5; A18-B13-C6; A18-B13-C7; A18-B13-C8; A18-B13-C9; A18-B13C10;

A18-B13- A18-B13- A18-B13- A18-B13- A18-1313- A18-B13C11; C12; C13; C14; C15; C16;

A18-B13- A18-B13- A18-B13- A18-B13- A18-B13- A18-B13C17; C18; C19; C20; C21; C22;

A18-B13- A18-B13- A18-B13- A18-B13- A18-B13- A18-B13C23; C24; C25; C26; C27; C28;

A18-B13- A18-B13- A18-B13- A18-B13- A18-B13- A18-B13C29; C30; C31; C32; C33; C34;

A18-B13- A18-B13- A18-B13- A18-B13- A18-B13- A18-B13C35; C36; C37; C38; C39; C40;

A18-B13- A18-B13- A18-B13- A18-B13- A18-B13- A18-B13C41; C42; C43; C44; C45; C46;

A19-B13-Cl; A19-B13-C2; A19-B13-C3; A19-B13-C4; A19-B13-C5; A19-B13-C6;

A19-B13-C7; A19-B13-C8; A19-B13-C9; A19-B13- A19-B13- A19-B13 C10; Cil; C12;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -96A19-B13- A19-B13- A19-B13- A19-B13- A19-B13- A19-B13C13; C14; C15; C16; C17; C18;

A19-B13- A19-B13- A19-B13- A19-B13- A19-B13- A19-B13C19; C20; C21; C22; C23; C24;

A19-B13- A19-B13- A19-B13- A19-B13- A19-B13- A19-B13C25; C26; C27; C28; C29; C30;

A19-B13- A19-B13- A19-B13- A19-B13- A19-B13- A19-B13C31; C32; C33; C34; C35; C36;

A19-B13- A19-B13- A19-B13- A19-B13- A19-B13- A19-B13C37; C38; C39; C40; C41; C42;

A19-B13- A19-B13- A19-B13- A19-B13- A20-B13-C1; A20-B13-C2;

C43; C44; C45; C46;

A20-B13-C3; A20-B13-C4; A20-B13-C5; A20-B13-C6; A20-B13-C7; A20-B13-C8;

A20-B13-C9; A20-B13- A20-B13- A20-B13- A20-B13- A20-B13C10; C11; C12; C13; C14;

A20-B13- A20-B13- A20-B13- A20-B13- A20-B13- A20-B13C15; C16; C17; C18; C19; C20;

A20-B13- A20-B13- A20-B13- A20-B13- A20-B13- A20-B13C21; C22; C23; C24; C25; C26;

A20-B13- A20-B13- A20-B13- A20-B13- A20-B13- A20-B13C27; C28; C29; C30; C31; C32;

A20-B13- A20-B13- A20-B13- A20-B13- A20-B13- A20-B13C33; C34; C35; C36; C37; C38;

A20-B13- A20-B13- A20-B13- A20-B13- A20-B13- A20-B13C39; C40; C41; C42; C43; C44;

A20-B13- A20-B13- A21-B13-C1; A21-B13-C2; A21-B13-C3; A21-B13-C4;

C45; C46;

A21-B13-C5; A21-B13-C6; A21-B13-C7; A21-B13-C8; A21-B13-C9; A21-B13C10;

A21-B13- A21-B13- A21-B13- A21-B13- A21-B13- A21-B13Cil; C12; C13; C14; C15; C16;

A21-B13- A21-B13- A21-B13- A21-B13- A21-B13- A21-B13C17; C18; C19; C20; C21; C22;

A21-B13- A21-B13- A21-B13- A21-B13- A21-B13- A21-B13C23; C24; C25; C26; C27; C28;

A21-B13- A21-B13- A21-B13- A21-B13- A21-B13- A21-B13C29; C30; C31; C32; C33; C34;

A21-B13- A21-B13- A21-B13- A21-B13- A21-B13- A21-B13C35; C36; C37; C38; C39; C40;

A21-B13- A21-B13- A21-B13- A21-B13- A21-B13- A21-B13C41; C42; C43; C44; C45; C46;

A22-B13-C1; A22-B13-C2; A22-B13-C3; A22-B13-C4; A22-B13-C5; A22-B13-C6;

A22-B13-C7; A22-B13-C8; A22-B13-C9; A22-B13- A22-B13- A22-B13 C10; Cil; C12;

A22-B13- A22-B13- A22-B13- A22-B13- A22-B13- A22-B13C13; C14; C15; Ci6; C17; C18;

A22-B13- A22-B13- A22-Bi3- A22-B13- A22-B13- A22-B13C19; C20; C21; C22; C23; C24;

A22-B13- A22-B13- A22-B13- A22-B13- A22-B13- A22-B13C25; C26; C27; C28; C29; C30;

A22-B13- A22-B13- A22-B13- A22-B13- A22-B13- A22-B13C31; C32; C33; C34; C35; C36;

A22-B13- A22-B13- A22-B13- A22-B13- A22-B13- A22-B13C37; C38; C39; C40; C41; C42;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -97A22-B13- A22-B13- A22-B13- A22-B13- A23-B13-Cl; A23-B13-C2;

C43; C44; C45; C46;

A23-B13-C3; A23-B13-C4; A23-B13-C5; A23-B13-C6; A23-B13-C7; A23-B13-C8;

A23-B13-C9; A23-B13- A23-B13- A23-B13- A23-B13- A23-B13C10; Cll; C12; C13; C14;

A23-B13- A23-B13- A23-B13- A23-B13- A23-B13- A23-B13C15; C16; C17; C18; C19; C20;

A23-B13- A23-B13- A23-B13- A23-B13- A23-B13- A23-B13C21; C22; C23; C24; C25; C26;

A23-B13- A23-B13- A23-B13- A23-B13- A23-B13- A23-B13C27; C28; C29; C30; C31; C32;

A23-B13- A23-B13- A23-B13- A23-B13- A23-B13- A23-B13C33; C34; C35; C36; C37; C38;

A23-B13- A23-B13- A23-B13- A23-B13- A23-B13- A23-B13C39; C40; C41; C42; C43; C44;

A23-B13- A23-B13- A24-B13-C1; A24-Bl3-C2; A24-B13-C3; A24-B13-C4;

C45; C46;

A24-B13-C5; A24-B13-C6; A24-B13-C7; A24-B13-C8; A24-B13-C9; A24-B13C10;

A24-B13- A24-B13- A24-B13- A24-B13- A24-B13- A24-B13Cll; C12; C13; C14; C15; C16;

A24-B13- A24-B13- A24-B13- A24-B13- A24-B13- A24-B13C17; C18; C19; C20; C21; C22;

A24-B13- A24-B13- A24-B13- A24-B13- A24-B13- A24-B13C23; C24; C25; C26; C27; C28;

A24-B13- A24-B13- A24-B13- A24-B13- A24-B13- A24-B13C29; C30; C31; C32; C33; C34;

A24-B13- A24-B13- A24-B13- A24-B13- A24-B13- A24-B13C35; C36; C37; C38; C39; C40;

A24-B13- A24-B13- A24-B13- A24-B13- A24-B13- A24-B13C41; C42; C43; C44; C45; C46;

A25-B13-Ci; A25-B13-C2; A25-B13-C3; A25-B13-C4; A25-B13-C5; A25-B13-C6;

A25-B13-C7; A25-B13-C8; A25-B13-C9; A25-B13- A25-B13- A25-B13 C10; Cli; C12;

A25-B13- A25-B13- A25-B13- A25-B13- A25-B13- A25-B13C13; C14; C15; C16; C17; C18;

A25-B13- A25-B13- A25-B13- A25-B13- A25-B13- A25-B13C19; C20; C21; C22; C23; C24;

A25-B13- A25-B13- A25-B13- A25-B13- A25-B13- A25-B13C25; C26; C27; C28; C29; C30;

A25-B13- A25-B13- A25-B13- A25-B13- A25-B13- A25-B13C31; C32; C33; C34; C35; C36;

A25-B13- A25-B13- A25-B13- A25-B13- A25-B13- A25-B13C37; C38; C39; C40; C41; C42;

A25-B13- A25-B13- A25-B13- A25-B13- A26-B13-Cl; A26-B13-C2;

C43; C44; C45; C46;

A26-B13-C3; A26-B13-C4; A26-B13-C5; A26-B13-C6; A26-B13-C7; A26-B13-C8;

A26-B13-C9; A26-B13- A26-B13- A26-B13- A26-B13- A26-B13C10; Cli; C12; C13; C14;

A26-B13- A26-B13- A26-B13- A26-B13- A26-B13- A26-B13C15; C16; C17; C18; C19; C20;

A26-B13- A26-B13- A26-B13- A26-B13- A26-B13- A26-B13C21; C22; C23; C24; C25; C26; .

A26-B13- A26-B13- A26-B13- A26-B13- A26-B13- A26-B13 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -98C27; C28; C29; C30; C31; C32;

A26-B13- A26-B13- A26-B13- A26-B13- A26-B13- A26-B13C33; C34; C35; C36; C37; C38;

A26-B13- A26-B13- A26-B13- A26-B13- A26-B13- A26-B13C39; C40; C41; C42; C43; C44;

A26-B13- A26-B13- A27-B13-C1; A27-B13-C2; A27-B13-C3; A27-B13-C4;

C45; C46;

A27-B13-C5; A27-B13-C6; A27-B13-C7; A27-B13-C8; A27-B13-C9; A27-B13C10;

A27-B13- A27-B13- A27-B13- A27-B13- A27-B13- A27-B13Cll; C12; C13; C14; C15; C16;

A27-B13- A27-B13- A27-B13- A27-B13- A27-B13- A27-B13C17; C18; C19; C20; C21; C22;

A27-B13- A27-B13- A27-B13- A27-B13- A27-B13- A27-B13C23; C24; C25; C26; C27; C28;

A27-B13- A27-B13- A27-B13- A27-B13- A27-B13- A27-B13C29; C30; C31; C32; C33; C34;

A27-B13- A27-B13- A27-B13- A27-B13- A27-B13- A27-B13C35; C36; C37; C38; C39; C40;

A27-B13- A27-B13- A27-B13- A27-B13- A27-B13- A27-B13C41; C42; C43; C44; C45; C46;

A28-B13-Cl; A28-B13-C2; A28-B13-C3; A28-B13-C4; A28-B13-C5; A28-B13-C6;

A28-B13-C7; A28-B13-C8; A28-B13-C9; A28-B13- A28-B13- A28-B13 C10; Cll; C12;

A28-B13- A28-B13- A28-B13- A28-B13- A28-B13- A28-B13C13; C14; C15; C16; C17; C18;

A28-B13- A28-B13- A28-B13- A28-B13- A28-B13- A28-B13C19; C20; C21; C22; C23; C24;

A28-B13- A28-B13- A28-B13- A28-B13- A28-B13- A28-B13C25; C26; C27; C28; C29; C30;

A28-B13- A28-B13- A28-B13- A28-B13- A28-B13- A28-B13C31; C32; C33; C34; C35; C36;

A28-B13- A28-B13- A28-B13- A28-B13- A28-B13- A28-B13C37; C38; C39; C40; C41; C42;

A28-B13- A28-B13- A28-B13- A28-B13- Al-B14-Cl; Al-B14-C2;

C43; C44; C45; C46;

Al-B14-C3; Al-B14-C4; Al-B14-C5; Al-B14-C6; Al-B14-C7; Al-B14-C8;

Al-B14-C9; Al-B14-C10; Al-B14-C11; Al-B14-C12; Al-B14-C13; Al-B14-C14;

Al-B14-C15; Al-B14-C16; Al-B14-C17; Al-B14-C18; Al-B14-C19; Al-B14-C20;

Al-B14-C21; Al-B14-C22; Al-B14-C23; Al-B14-C24; Al-B14-C25; Al-B14-C26;

Al-B14-C27; Al-B14-C28; Al-B14-C29; Al-B14-C30; Ai-B14-C31; Al-B14-C32;

Al-B14-C33; Al-B14-C34; Al-B14-C35; Al-B14-C36; Al-B14-C37; Al-B14-C38;

Al-B14-C39; Al-B14-C40; Al-B14-C41; Al-B14-C42; Al-B14-C43; Ai-B14-C44;

Al-B14-C45; Al-B14-C46; A2-B14-Cl; A2-B14-C2; A2-B14-C3; A2-B14-C4;

A2-B14-C5; A2-B14-C6; A2-B14-C7; A2-B14-C8; A2-B14-C9; A2-B14-C10;

A2-B14-Cil; A2-B14-C12; A2-B14-C13; A2-B14-C14; A2-B14-C15; A2-B14-C16;

A2-B14-C17; A2-B14-C18; A2-B14-C19; A2-B14-C20; A2-B14-C21; A2-B14-C22;

A2-B14-C23; A2-B14-C24; A2-B14-C25; A2-B14-C26; A2-B14-C27; A2-B14-C28;

A2-B14-C29; A2-B14-C30; A2-B14-C31; A2-B14-C32; A2-B14-C33; A2-B14-C34;

A2-B14-C35; A2-B14-C36; A2-B14-C37; A2-B14-C38; A2-B14-C39; A2-B14-C40;

A2-B14-C41; A2-B14-C42; A2-B14-C43; A2-B14-C44; A2-B14-C45; A2-B14-C46;

A3-B14-Cl; A3-B14-C2; A3-B14-C3; A3-B14-C4; A3-B14-C5; A3-B14-C6;

A3-B14-C7; A3-B14-C8; A3-B14-C9; A3-B14-C10; A3-B14-C11; A3-B14-C12;

A3-B14-C13; A3-B14-C14; A3-B14-C15; A3-B14-C16; A3-B14-C17; A3-B14-C18;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -99A3-B14-C19; A3-B14-C20; A3-B14-C21; A3-B14-C22; A3-B14-C23; A3-B14-C24;

A3-B14-C25; A3-B14-C26; A3-B14-C27; A3-B14-C28; A3-B14-C29; A3-B14-C30;

A3-B14-C31; A3-B14-C32; A3-B14-C33; A3-B14-C34; A3-B14-C35; A3-B14-C36;

A3-B14-C37; A3-B14-C38; A3-B14-C39; A3-B14-C40; A3-B14-C41; A3-B14-C42;

A3-B14-C43; A3-B14-C44; A3-B14-C45; A3-B14-C46; A4-B14-C1; A4-B14-C2;

A4-B14-C3; A4-B14-C4; A4-B14-C5; A4-B14-C6; A4-B14-C7; A4-B14-C8;

A4-B14-C9; A4-B14-C10; A4-B14-C11; A4-B14-C12; A4-B14-C13; A4-B14-C14;

A4-B14-C15; A4-B14-C16; A4-B14-C17; A4-B14-C18; A4-B14-C19; A4-B14-C20;

A4-B14-C21; A4-B14-C22; A4-B14-C23; A4-B14-C24; A4-B14-C25; A4-B14-C26;

A4-B14-C27; A4-B14-C28; A4-B14-C29; A4-B14-C30; A4-B14-C31; A4-B14-C32;

A4-B14-C33; A4-B14-C34; A4-B14-C35; A4-B14-C36; A4-B14-C37; A4-B14-C38;

A4-B14-C39; A4-B14-C40; A4-B14-C41; A4-B14-C42; A4-B14-C43; A4-B14-C44;

A4-B14-C45; A4-B14-C46; A5-B14-Cl; A5-B14-C2; A5-B14-C3; A5-B14-C4;

A5-B14-C5; A5-B14-C6; A5-B14-C7; A5-B14-C8; A5-B14-C9; A5-B14-C10;

A5-B14-C11; A5-B14-C12; A5-B14-C13; A5-B14-C14; A5-B14-C15; A5-B14-C16;

A5-B14-C17; A5-B14-C18; A5-B14-C19; A5-B14-C20; A5-B14-C21; A5-B14-C22;

A5-B14-C23; A5-B14-C24; A5-B14-C25; A5-B14-C26; A5-B14-C27; A5-B14-C28;

A5-B14-C29; A5-B14-C30; A5-B14-C31; A5-B14-C32; A5-B14-C33; A5-B14-C34;

A5-B14-C35; A5-B14-C36; A5-B14-C37; A5-B14-C38; A5-B14-C39; A5-B14-C40;

A5-B14-C41; A5-B14-C42; A5-B14-C43; A5-B14-C44; A5-B14-C45; A5-B14-C46;

A6-B14-C1; A6-B14-C2; A6-B14-C3; A6-B14-C4; A6-B14-C5; A6-B14-C6;

A6-B14-C7; A6-B14-C8; A6-B14-C9; A6-B14-C10; A6-B14-C11; A6-B14-C12;

A6-B14-C13; A6-B14-C14; A6-B14-C15; A6-B14-C16; A6-B14-C17; A6-B14-C18;

A6-B14-C19; A6-B14-C20; A6-B14-C21; A6-B14-C22; A6-B14-C23; A6-B14-C24;

A6-B14-C25; A6-B14-C26; A6-B14-C27; A6-B14-C28; A6-B14-C29; A6-B14-C30;

A6-B14-C31; A6-B14-C32; A6-B14-C33; A6-B14-C34; A6-B14-C35; A6-B14-C36;

A6-B14-C37; A6-B14-C38; A6-B14-C39; A6-B14-C40; A6-B14-C41; A6-B14-C42;

A6-B14-C43; A6-B14-C44; A6-B14-C45; A6-B14-C46; A7-B14-Cl; A7-B14-C2;

A7-B14-C3; A7-B14-C4; A7-B14-C5; A7-B14-C6; A7-B14-C7; A7-B14-C8;

A7-B14-C9; A7-B14-C10; A7-B14-C11; A7-B14-C12; A7-B14-C13; A7-B14-C14;

A7-B14-C15; A7-B14-C16; A7-B14-C17; A7-B14-C18; A7-B14-C19; A7-B14-C20;

A7-B14-C21; A7-B14-C22; A7-B14-C23; A7-B14-C24; A7-B14-C25; A7-B14-C26;

A7-B14-C27; A7-B14-C28; A7-B14-C29; A7-B14-C30; A7-B14-C31; A7-B14-C32;

A7-B14-C33; A7-B14-C34; A7-B14-C35; A7-B14-C36; A7-B14-C37; A7-B14-C38;

A7-B14-C39; A7-B14-C40; A7-B14-C41; A7-B14-C42; A7-B14-C43; A7-B14-C44;

A7-B14-C45; A7-B14-C46; A8-B14-C1; A8-B14-C2; A8-B14-C3; A8-B14-C4;

A8-B14-C5; A8-B14-C6; A8-B14-C7; A8-B14-C8; A8-B14-C9; A8-B14-C10;

A8-B14-C11; A8-B14-C12; A8-B14-C13; A8-B14-C14; A8-B14-C15; A8-B14-C16;

A8-B14-C17; A8-B14-C18; A8-B14-C19; A8-B14-C20; A8-B14-C21; A8-B14-C22;

A8-B14-C23; A8-B14-C24; A8-B14-C25; A8-B14-C26; A8-B14-C27; A8-B14-C28;

A8-B14-C29; A8-B14-C30; A8-B14-C31; A8-B14-C32; A8-B14-C33; A8-B14-C34;

A8-B14-C35; A8-B14-C36; A8-B14-C37; A8-B14-C38; A8-B14-C39; A8-B14-C40;

A8-B14-C41; A8-B14-C42; A8-B14-C43; A8-B14-C44; A8-B14-C45; A8-B14-C46;

A9-B14-C1; A9-B14-C2; A9-B14-C3; A9-B14-C4; A9-B14-C5; A9-B14-C6;

A9-B14-C7; A9-B14-C8; A9-B14-C9; A9-B14-C10; A9-B14-C11; A9-B14-C12;

A9-B14-C13; A9-B14-C14; A9-B14-C15; A9-B14-C16; A9-B14-C17; A9-B14-C18;

A9-B14-C19; A9-B14-C20; A9-B14-C21; A9-B14-C22; A9-B14-C23; A9-B14-C24;

A9-B14-C25; A9-B14-C26; A9-B14-C27; A9-B14-C28; A9-B14-C29; A9-B14-C30;

A9-B14-C31; A9-B14-C32; A9-B14-C33; A9-B14-C34; A9-B14-C35; A9-B14-C36;

A9-B14-C37; A9-B14-C38; A9-B14-C39; A9-B14-C40; A9-B14-C41; A9-B14-C42;

A9-B14-C43; A9-B14-C44; A9-B14-C45; A9-B14-C46; A10-B14-C1; A10-B14-C2;

A10-B14-C3; A10-B14-C4; A10-B14-C5; A10-B14-C6; A10-B14-C7; A10-B14-C8;

A10-B14-C9; A10-B14- A10-B14- A10-B14- A10-B14- A10-B14 C10; Cll; C12; C13; C14;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -100A10-B14- A10-B14- A10-B14- A10-B14- A10-B14- A10-B14C15; C16; C17; C18; C19; C20;

A10-B14- A10-B14- A10-B14- A10-B14- A10-B14- A10-B14C21; C22; C23; C24; C25; C26;

A10-B14- A10-B14- A10-B14- A10-B14- A10-B14- A10-B14C27; C28; C29; C30; C31; C32;

A10-B14- A10-B14- A10-B14- A10-B14- A10-B14- A10-B14C33; C34; C35; C36; C37; C38;

A10-B14- A10-B14- A10-B14- A10-B14- A10-B14- A10-B14C39; C40; C41; C42; C43; C44;

A10-B14- A10-B14- A11-B14-Cl; All-B14-C2; All-B14-C3; All-B14-C4;

C45; C46;

All-B14-C5; All-B14-C6; All-B14-C7; All-B14-C8; All-B14-C9; All-B14C10;

All-B14- All-B14- All-B14- All-B14- All-B14- All-B14Cli; C12; C13; C14; C15; C16;

All-B14- All-B14- A11-B14- All-B14- All-B14- All-B14C17; C18; C19; C20; C21; C22;

All-B14- All-B14- A11-B14- All-B14- All-B14- All-B14C23; C24; C25; C26; C27; C28;

All-B14- All-B14- A11-B14- All-B14- All-B14- All-B14C29; C30; C31; C32; C33; C34;

All-B14- All-B14- Ali-B14- All-B14- All-B14- A11-B14C35; C36; C37; C38; C39; C40;

All-B14- All-B14- All-B14- Ail-B14- All-B14- All-B14C41; C42; C43; C44; C45; C46;

A12-B14-Cl; A12-B14-C2; A12-B14-C3; A12-B14-C4; A12-B14-C5; A12-B14-C6;

A12-B14-C7; A12-B14-C8; A12-B14-C9; A12-B14- A12-B14- A12-B14 C10; Cll; C12;

A12-B14- A12-B14- A12-B14- A12-B14- A12-B14- A12-B14C13; C14; C15; C16; C17; C18;

A12-B14- A12-B14- A12-B14- A12-B14- A12-B14- A12-B14C19; C20; C21; C22; C23; C24;

A12-B14- A12-B14- A12-B14- A12-B14- A12-B14- A12-B14C25; C26; C27; C28; C29; C30;

A12-B14- A12-B14- A12-B14- A12-B14- A12-B14- A12-B14C31; C32; C33; C34; C35; C36;

A12-B14- A12-B14- A12-B14- A12-B14- A12-B14- A12-B14C37; C38; C39; C40; C41; C42;

A12-B14- A12-B14- A12-B14- A12-B14- A13-B14-Cl; A13-B14-C2;

C43; C44; C45; C46;

A13-B14-C3; A13-B14-C4; A13-B14-C5; A13-B14-C6; A13-B14-C7; A13-B14-C8;

A13-B14-C9; A13-B14- A13-B14- A13-B14- A13-B14- A13-B14C10; Cli; C12; C13; C14;

A13-B14- A13-B14- A13-B14- A13-B14- A13-B14- A13-B14C15; C16; C17; C18; C19; C20;

A13-B14- A13-B14- A13-B14- A13-B14- A13-B14- A13-B14C21; C22; C23; C24; C25; C26;

A13-B14- A13-B14- A13-B14- A13-B14- A13-B14- A13-B14C27; C28; C29; C30; C31; C32;

A13-B14- A13-B14- A13-B14- A13-B14- A13-B14- A13-B14C33; C34; C35; C36; C37; C38;

A13-B14- A13-B14- A13-B14- A13-B14- A13-B14- A13-B14C39; C40; C41; C42; C43; C44;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -101A13-B14- A13-B14- A14-B14-C1; A14-B14-C2; A14-B14-C3; A14-B14-C4;

C45; C46;

A14-B14-C5; A14-B14-C6; A14-B14-C7; A14-B14-C8; A14-B14-C9; A14-B14C10;

A14-B14- A14-B14- A14-B14- A14-B14- A14-B14- A14-B14Cll; C12; C13; C14; C15; C16;

A14-B14- A14-B14- A14-B14- A14-B14- A14-B14- A14-B14C17; C18; C19; C20; C21; C22;

A14-B14- A14-B14- A14-B14- A14-B14- A14-B14- A14-B14C23; C24; C25; C26; C27; C28;

A14-B14- A14-B14- A14-B14- A14-B14- A14-B14- A14-B14C29; C30; C31; C32; C33; C34;

A14-B14- A14-B14- A14-B14- A14-B14- A14-B14- A14-B14C35; C36; C37; C38; C39; C40;

A14-B14- A14-B14- A14-B14- A14-B14- A14-B14- A14-B14C41; C42; C43; C44; C45; C46;

A15-B14-Ci; A15-B14-C2; A15-B14-C3; A15-B14-C4; A15-B14-C5; A15-B14-C6;

A15-B14-C7; A15-B14-C8; A15-B14-C9; A15-B14- A15-B14- A15-B14 C10; Cll; C12;

A15-B14- A15-B14- A15-B14- A15-B14- A15-B14- A15-B14C13; C14; C15; C16; C17; C18;

A15-B14- A15-B14- A15-B14- A15-B14- A15-B14- A15-B14C19; C20; C21; C22; C23; C24;

A15-B14- A15-B14- A15-B14- A15-B14- A15-B14- A15-B14C25; C26; C27; C28; C29; C30;

A15-B14- A15-B14- A15-B14- A15-B14- A15-B14- A15-B14C31; C32; C33; C34; C35; C36;

A15-B14- A15-B14- A15-B14- A15-B14- A15-B14- A15-B14C37; C38; C39; C40; C41; C42;

A15-B14- A15-B14- A15-B14- A15-B14- A16-B14-C1; A16-B14-C2;

C43; C44; C45; C46;

A16-B14-C3; A16-B14-C4; A16-B14-C5; A16-B14-C6; A16-B14-C7; A16-B14-C8;

A16-B14-C9; A16-B14- A16-B14- A16-B14- A16-B14- A16-B14C10; C11; C12; C13; C14;

A16-B14- A16-B14- A16-B14- A16-B14- A16-B14- A16-B14C15; C16; C17; C18; C19; C20;

A16-B14- A16-B14- A16-B14- A16-B14- A16-B14- A16-B14C21; C22; C23; C24; C25; C26;

A16-B14- A16-B14- A16-B14- A16-B14- A16-B14- A16-B14C27; C28; C29; C30; C31; C32;

A16-B14- A16-B14- A16-B14- A16-B14- A16-B14- A16-B14C33; C34; C35; C36; C37; C38;

A16-B14- A16-B14- A16-B14- A16-B14- A16-B14- A16-B14C39; C40; C41; C42; C43; C44;

A16-B14- A16-B14- A17-B14-Cl; A17-B14-C2; A17-B14-C3; A17-B14-C4;

C45; C46;

A17-B14-C5; A17-B14-C6; A17-B14-C7; A17-B14-C8; A17-B14-C9; A17-B14C10;

A17-B14- A17-B14- A17-B14- A17-B14- A17-B14- A17-B14Cli; C12; C13; C14; C15; C16;

A17-B14- A17-B14- A17-B14- A17-B14- A17-B14- A17-B14C17; C18; C19; C20; C21; C22;

A17-B14- A17-B14- A17-B14- A17-B14- A17-B14- A17-B14C23; C24; C25; C26; C27; C28;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -102A17-B14- A17-B14- A17-B14- A17-B14- A17-B14- A17-B14C29; C30; C31; C32; C33; C34;

A17-B14- A17-B14- A17-B14- A17-B14- A17-B14- A17-B14C35; C36; C37; C38; C39; C40;

A17-B14- A17-B14- A17-B14- A17-B14- A17-B14- A17-B14C41; C42; C43; C44; C45; C46;

A18-B14-Cl; A18-B14-C2; A18-B14-C3; A18-B14-C4; A18-B14-C5; A18-B14-C6;

A18-B14-C7; A18-B14-C8; A18-B14-C9; A18-B14- A18-B14- A18-B14 C10; Cll; C12;

A18-B14- A18-B14- A18-B14- A18-B14- A18-B14- A18-B14C13; C14; C15; C16; C17; C18;

A18-B14- A18-B14- A18-B14- A18-B14- A18-B14- A18-B14C19; C20; C21; C22; C23; C24;

A18-B14- A18-B14- A18-B14- A18-B14- A18-B14- A18-B14C25; C26; C27; C28; C29; C30;

A18-B14- A18-B14- A18-B14- A18-B14- A18-B14- A18-B14C31; C32; C33; C34; C35; C36;

A18-B14- A18-B14- A18-B14- A18-B14- A18-B14- A18-B14C37; C38; C39; C40; C41; C42;

A18-B14- A18-B14- A18-B14- A18-B14- A19-B14-Cl; A19-B14-C2;

C43; C44; C45; C46;

A19-B14-C3; A19-B14-C4; A19-B14-C5; A19-B14-C6; A19-B14-C7; A19-B14-C8;

A19-B14-C9; A19-B14- A19-B14- A19-B14- A19-B14- A19-B14C10; Cll; C12; C13; C14;

A19-B14- A19-B14- A19-B14- A19-B14- A19-B14- A19-B14C15; C16; C17; C18; C19; C20;

A19-B14- A19-B14- A19-B14- A19-B14- A19-B14- A19-B14C21; C22; C23; C24; C25; C26;

A19-B14- A19-B14- A19-B14- A19-B14- A19-B14- A19-B14C27; C28; C29; C30; C31; C32;

A19-B14- A19-B14- A19-B14- A19-B14- A19-B14- A19-B14C33; C34; C35; C36; C37; C38;

A19-B14- A19-B14- A19-B14- A19-B14- A19-B14- A19-B14C39; C40; C41; C42; C43; C44;

A19-B14- A19-B14- A20-B14-C1; A20-B14-C2; A20-B14-C3; A20-B14-C4;

C45; C46;

A20-B14-C5; A20-B14-C6; A20-B14-C7; A20-B14-C8; A20-B14-C9; A20-B14C10;

A20-B14- A20-B14- A20-B14- A20-B14- A20-B14- A20-B14C11; C12; C13; C14; C15; C16;

A20-B14- A20-B14- A20-B14- A20-B14- A20-B14- A20-B14C17; C18; C19; C20; C21; C22;

A20-B14- A20-B14- A20-B14- A20-B14- A20-B14- A20-B14C23; C24; C25; C26; C27; C28;

A20-B14- A20-B14- A20-B14- A20-B14- A20-B14- A20-B14C29; C30; C31; C32; C33; C34;

A20-B14- A20-B14- A20-B14- A20-B14- A20-B14- A20-B14C35; C36; C37; C38; C39; C40;

A20-B14- A20-B14- A20-B14- A20-B14- A20-B14- A20-B14C41; C42; C43; C44; C45; C46;

A21-B14-C1; A21-B14-C2; A21-B14-C3; A21-B14-C4; A21-B14-C5; A21-B14-C6;

A21-B14-C7; A21-B14-C8; A21-B14-C9; A21-B14- A21-B14- A21-B14 C10; Cli; C12;

A21-B14- A21-B14- A21-B14- A21-B14- A21-B14- A21-B14 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -103C13; C14; C15; C16; C17; C18;

A21-B14- A21-B14- A21-B14- A21-B14- A21-B14- A21-B14C19; C20; C21; C22; C23; C24;

A21-B14- A21-B14- A21-B14- A21-B14- A21-B14- A21-B14C25; C26; C27; C28; C29; C30;

A21-B14- A21-B14- A21-B14- A21-B14- A21-B14- A21-B14C31; C32; C33; C34; C35; C36;

A21-B14- A21-B14- A21-B14- A21-B14- A21-B14- A21-B14C37; C38; C39; C40; C41; C42;

A21-B14- A21-B14- A21-B14- A21-B14- A22-B14-Cl; A22-B14-C2;

C43; C44; C45; C46;

A22-B14-C3; A22-B14-C4; A22-B14-C5; A22-B14-C6; A22-B14-C7; A22-B14-C8;

A22-B14-C9; A22-B14- A22-B14- A22-B14- A22-B14- A22-B14C10; Cl l; C12; C13; C14;

A22-B14- A22-B14- A22-B14- A22-B14- A22-B14- A22-B14C15; C16; C17; C18; C19; C20;

A22-B14- A22-B14- A22-B14- A22-B14- A22-B14- A22-B14C21; C22; C23; C24; C25; C26;

A22-B14- A22-B14- A22-B14- A22-B14- A22-B14- A22-B14C27; C28; C29; C30; C31; C32;

A22-B14- A22-B14- A22-B14- A22-B14- A22-B14- A22-B14C33; C34; C35; C36; C37; C38;

A22-B14- A22-B14- A22-B14- A22-B14- A22-B14- A22-B14C39; C40; C41; C42; C43; C44;

A22-B14- A22-B14- A23-B14-C1; A23-B14-C2; A23-B14-C3; A23-B14-C4;

C45; C46;

A23-B14-C5; A23-B14-C6; A23-B14-C7; A23-B14-C8; A23-B14-C9; A23-B14C10;

A23-B14- A23-B14- A23-B14- A23-B14- A23-B14- A23-B14Cll; C12; C13; C14; C15; _ C16;

A23-B14- A23-B14- A23-B14- A23-B14- A23-B14- A23-B14C17; C18; C19; C20; C21; C22;

A23-B14- A23-B14- A23-B14- A23-B14- A23-B14- A23-B14-.

C23; C24; C25; C26; C27; C28;

A23-B14- A23-B14- A23-B14- A23-B14- A23-B14- A23-B14C29; C30; C31; C32; C33; C34;

A23-B14- A23-B14- A23-B14- A23-B14- A23-B14- A23-B14C35; C36; C37; C38; C39; C40;

A23-B14- A23-B14- A23-B14- A23-B14- A23-B14- A23-B14C41; C42; C43; C44; C45; C46;

A24-B14-Cl; A24-B14-C2; A24-B14-C3; A24-B14-C4; A24-B14-C5; A24-B14-C6;

A24-B14-C7; A24-B14-C8; A24-B14-C9; A24-B14- A24-B14- A24-B14 C10; Cil; C12;

A24-B14- A24-B14- A24-B14- A24-B14- A24-B14- A24-B14C13; C14; C15; C16; C17; C18;

A24-B14- A24-B14- A24-B14- A24-B14- A24-B14- A24-B14C19; C20; C21; C22; C23; C24;

A24-B14- A24-B14- A24-B14- A24-B14- A24-B14- A24-B14C25; C26; C27; C28; C29; C30;

A24-B14- A24-B14- A24-B14- A24-B14- A24-B14- A24-B14C31; C32; C33; C34; C35; C36;

A24-B14- A24-B14- A24-B14- A24-B14- A24-B14- A24-B14C37; C38; C39; C40; C41; C42;

A24-B14- A24-B14- A24-B14- A24-B14- A25-B14-Cl; A25-B14-C2;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -104C43; C44; C45; C46;

A25-B14-C3; A25-B14-C4; A25-B14-C5; A25-B14-C6; A25-B14-C7; A25-B14-C8;

A25-B14-C9; A25-B14- A25-B14- A25-B14- A25-B14- A25-B14C10; Cll; C12; C13; C14;

A25-B14- A25-B14- A25-B14- A25-B14- A25-B14- A25-B14C15; C16; C17; C18; C19; C20;

A25-B14- A25-B14- A25-B14- A25-B14- A25-B14- A25-B14C21; C22; C23; C24; C25; C26;

A25-B14- A25-B14- A25-B14- A25-B14- A25-B14- A25-B14C27; C28; C29; C30; C31; C32;

A25-B14- A25-B14- A25-B14- A25-B14- A25-B14- A25-B14C33; C34; C35; C36; C37; C38;

A25-B14- A25-B14- A25-B14- A25-B14- A25-B14- A25-B14C39; C40; C41; C42; C43; C44;

A25-B14- A25-B14- A26-B14-CI; A26-B14-C2; A26-B14-C3; A26-B14-C4;

C45; C46;

A26-B14-C5; A26-B14-C6; A26-B14-C7; A26-B14-C8; A26-B14-C9; A26-B14C10;

A26-B14- A26-B14- A26-B14- A26-B14- A26-B14- A26-B14C11; C12; C13; C14; C15; C16;

A26-B14- A26-B14- A26-B14- A26-B14- A26-B14- A26-B14C17; C18; C19; C20; C21; C22;

A26-B14- A26-B14- A26-B14- A26-B14- A26-B14- A26-B14C23; C24; C25; C26; C27; C28;

A26-B14- A26-B14- A26-B14- A26-B14- A26-B14- A26-B14C29; C30; C31; C32; C33; C34;

A26-B14- A26-B14- A26-B14- A26-B14- A26-B14- A26-B14C35; C36; C37; C38; C39; C40;

A26-B14- A26-B14- A26-B14- A26-B14- A26-B14- A26-B14C41; C42; C43; C44; C45; C46;

A27-B14-Cl; A27-B14-C2; A27-B14-C3; A27-B14-C4; A27-B14-C5; A27-B14-C6;

A27-B14-C7; A27-B14-C8; A27-B14-C9; A27-B14- A27-B14- A27-B14 C10; Cil; C12;

A27-B14- A27-B14- A27-B14- A27-B14- A27-B14- A27-B14C13; C14; C15; C16; C17; C18;

A27-B14- A27-B14- A27-B14- A27-B14- A27-B14- A27-B14C19; C20; C21; C22; C23; C24;

A27-B14- A27-B14- A27-B14- A27-B14- A27-B14- A27-B14C25; C26; C27; C28; C29; C30;

A27-B14- A27-B14- A27-B14- A27-B14- A27-B14- A27-B14C31; C32; C33; C34; C35; C36;

A27-B14- A27-B14- A27-B14- A27-B14- A27-B14- A27-B14C37; C38; C39; C40; C41; C42;

A27-B14- A27-B14- A27-B14- A27-B14- A28-B14-Ci; A28-B14-C2;

C43; C44; C45; C46;

A28-B14-C3; A28-B14-C4; A28-B14-C5; A28-B14-C6; A28-B14-C7; A28-B14-C8;

A28-B14-C9; A28-B14- A28-B14- A28-B14- A28-B14- A28-B14C10; Cll; C12; C13; C14;

A28-B14- A28-B14- A28-B14- A28-B14- A28-B14- A28-B14C15; C16; C17; C18; C19; C20;

A28-B14- A28-B14- A28-B14- A28-B14- A28-B14- A28-B14C21; C22; C23; C24; C25; C26;

A28-B14- A28-B14- A28-B14- A28-B14- A28-B14- A28-B14C27; C28; C29; C30; C31; C32;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -105A28-B14- A28-B14- A28-B14- A28-B14- A28-B14- A28-B14C33; C34; C35; C36; C37; C38;

A28-B14- A28-B14- A28-B14- A28-B14- A28-B14- A28-B14C39; C40; C41; C42; C43; C44;

A28-B14- A28-B14- Al-B15-Cl; Al-B15-C2; Al-B15-C3; Al-B15-C4;

C45; C46;

Al-B15-C5; A1-B15-C6; Al-B15-C7; Al-B15-C8; Al-B15-C9; Al-B15-C10;

Al-B15-Cll; Al-B15-C12; Al-B15-C13; Al-B15-C14; Al-B15-C15; Al-B15-C16;

Al-B15-C17; Al-B15-C18; Al-B15-C19; Al-B15-C20; Al-B15-C21; Al-B15-C22;

Al-B15-C23; Al-B15-C24; Al-B15-C25; Al-B15-C26; Al-B15-C27; Al-B15-C28;

Al-B15-C29; Al-B15-C30; A1-B15-C31; Al-B15-C32; Al-B15-C33; Al-B15-C34;

Al-B15-C35; Al-B15-C36; Al-B15-C37; Al-B15-C38; Al-B15-C39; Al-B15-C40;

A1-B15-C41; Al-B15-C42; Al-B15-C43; Al-B15-C44; Al-B15-C45; Al-B15-C46;

A2-B15-Cl; A2-B15-C2; A2-B15-C3; A2-B15-C4; A2-B15-C5; A2-B15-C6;

A2-B15-C7; A2-B15-C8; A2-B15-C9; A2-B15-C10; A2-B15-Cll; A2-B15-C12;

A2-B15-C13; A2-B15-C14; A2-B15-C15; A2-B15-C16; A2-B15-C17; A2-B15-C18;

A2-B15-C19; A2-B15-C20; A2-B15-C21; A2-B15-C22; A2-B15-C23; A2-B15-C24;

A2-B15-C25; A2-B15-C26; A2-B15-C27; A2-B15-C28; A2-B15-C29; A2-B15-C30;

A2-B15-C31; A2-B15-C32; A2-B15-C33; A2-B15-C34; A2-B15-C35; A2-B15-C36;

A2-B15-C37; A2-B15-C38; A2-B15-C39; A2-B15-C40; A2-B15-C41; A2-B15-C42;

A2-B15-C43; A2-B15-C44; A2-B15-C45; A2-B15-C46; A3-B15-C1; A3-B15-C2;

A3-B15-C3; A3-B15-C4; A3-B15-C5; A3-B15-C6; A3-B15-C7; A3-B15-C8;

A3-B15-C9; A3-B15-C10; A3-B15-C11; A3-B15-C12; A3-B15-C13; A3-B15-C14;

A3-B15-C15; A3-B15-C16; A3-B15-C17; A3-B15-C18; A3-B15-C19; A3-B15-C20;

A3-B15-C21; A3-B15-C22; A3-B15-C23; A3-B15-C24; A3-B15-C25; A3-B15-C26;

A3-B15-C27; A3-B15-C28; A3-B15-C29; A3-B15-C30; A3-B15-C31; A3-B15-C32;

A3-B15-C33; A3-B15-C34; A3-B15-C35; A3-B15-C36; A3-B15-C37; A3-B15-C38;

A3-B15-C39; A3-B15-C40; A3-B15-C41; A3-B15-C42; A3-B15-C43; A3-B15-C44;

A3-B15-C45; A3-B15-C46; A4-B15-Cl; A4-B15-C2; A4-B15-C3; A4-B15-C4;

A4-B15-C5; A4-B15-C6; A4-B15-C7; A4-B15-C8; A4-B15-C9; A4-B15-C10;

A4-B15-Cll; A4-B15-C12; A4-B15-C13; A4-B15-C14; A4-B15-C15; A4-B15-C16;

A4-B15-C17; A4-B15-C18; A4-B15-C19; A4-B15-C20; A4-B15-C21; A4-B15-C22;

A4-B15-C23; A4-B15-C24; A4-B15-C25; A4-B15-C26; A4-B15-C27; A4-B15-C28;

A4-B15-C29; A4-B15-C30; A4-B15-C31; A4-B15-C32; A4-B15-C33; A4-B15-C34;

A4-B15-C35; A4-B15-C36; A4-B15-C37; A4-B15-C38; A4-B15-C39; A4-B15-C40;

A4-B15-C41; A4-B15-C42; A4-B15-C43; A4-B15-C44; A4-B15-C45; A4-B15-C46;

A5-B15-C1; A5-B15-C2; A5-B15-C3; A5-B15-C4; A5-B15-C5; A5-B15-C6;

A5-B15-C7; A5-B15-C8; A5-B15-C9; A5-B15-C10; A5-B15-Cll; A5-B15-C12;

A5-B15-C13; A5-B15-C14; A5-B15-C15; A5-B15-C16; A5-B15-C17; A5-B15-C18;

A5-B15-C19; A5-B15-C20; A5-B15-C21; A5-B15-C22; A5-B15-C23; A5-B15-C24;

A5-B15-C25; A5-B15-C26; A5-B15-C27; A5-B15-C28; A5-B15-C29; A5-B15-C30;

A5-B15-C31; A5-B15-C32; A5-B15-C33; A5-B15-C34; A5-B15-C35; A5-B15-C36;

A5-B15-C37; A5-B15-C38; A5-B15-C39; A5-B15-C40; A5-B15-C41; A5-B15-C42;

A5-B15-C43; A5-B15-C44; A5-B15-C45; A5-B15-C46; A6-B15-C1; A6-B15-C2;

A6-B15-C3; A6-B15-C4; A6-B15-C5; A6-B15-C6; A6-B15-C7; A6-B15-C8;

A6-B15-C9; A6-B15-C10; A6-B15-C11; A6-B15-C12; A6-B15-C13; A6-B15-C14;

A6-B15-C15; A6-B15-C16; A6-B15-C17; A6-B15-C18; A6-B15-C19; A6-B15-C20;

A6-B15-C21; A6-B15-C22; A6-B15-C23; A6-B15-C24; A6-B15-C25; A6-B15-C26;

A6-B15-C27; A6-B15-C28; A6-B15-C29; A6-B15-C30; A6-B15-C31; A6-B15-C32;

A6-B15-C33; A6-B15-C34; A6-B15-C35; A6-B15-C36; A6-B15-C37; A6-B15-C38;

A6-B15-C39; A6-B15-C40; A6-B15-C41; A6-B15-C42; A6-B15-C43; A6-B15-C44;

A6-B15-C45; A6-B15-C46; A7-B15-Cl; A7-B15-C2; A7-B15-C3; A7-B15-C4;

A7-B15-C5; A7-B15-C6; A7-B15-C7; A7-B15-C8; A7-B15-C9; A7-B15-C10;

A7-B15-Cll; A7-B15-C12; A7-B15-C13; A7-B15-C14; A7-B15-C15; A7-B15-C16;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -106A7-B15-C17; A7-B15-C18; A7-B15-C19; A7-B15-C20; A7-B15-C21; A7-B15-C22;

A7-B15-C23; A7-B15-C24; A7-B15-C25; A7-B15-C26; A7-B15-C27; A7-B15-C28;

A7-B15-C29; A7-B15-C30; A7-B15-C31; A7-B15-C32; A7-B15-C33; A7-B15-C34;

A7-B15-C35; A7-B15-C36; A7-B15-C37; A7-B15-C38; A7-B15-C39; A7-B15-C40;

A7-B15-C41; A7-B15-C42; A7-B15-C43; A7-B15-C44; A7-B15-C45; A7-B15-C46;

A8-B15-Cl; AS-B15-C2; A8-B15-C3; A8-B15-C4; A8-B15-C5; A8-B15-C6;

A8-B15-C7; AS-B15-C8; A8-B15-C9; A8-B15-C10; A8-B15-C11; A8-B15-C12;

A8-B15-C13; A8-B15-C14; A8-B15-C15; A8-B15-C16; A8-B15-C17; A8-B15-C18;

A8-B15-C19; A8-B15-C20; A8-B15-C21; A8-B15-C22; A8-B15-C23; A8-B15-C24;

A8-B15-C25; A8-B15-C26; A8-B15-C27; A8-B15-C28; A8-B15-C29; A8-B15-C30;

A8-B15-C31; A8-B15-C32; A8-B15-C33; A8-B15-C34; A8-B15-C35; A8-B15-C36;

A8-B15-C37; A8-B15-C38; A8-B15-C39; A8-B15-C40; A8-B15-C41; A8-B15-C42;

A8-B15-C43; A8-B15-C44; A8-B15-C45; A8-B15-C46; A9-B15-C1; A9-B15-C2;

A9-B15-C3; A9-B15-C4; A9-B15-C5; A9-B15-C6; A9-B15-C7; A9-B15-C8;

A9-B15-C9; A9-B15-C10; A9-B15-C11; A9-B15-C12; A9-B15-C13; A9-B15-C14;

A9-B15-C15; A9-B15-C16; A9-B15-C17; A9-B15-C18; A9-B15-C19; A9-B15-C20;

A9-B15-C21; A9-B15-C22; A9-B15-C23; A9-B15-C24; A9-B15-C25; A9-B15-C26;

A9-B15-C27; A9-B15-C28; A9-B15-C29; A9-B15-C30; A9-B15-C31; A9-B15-C32;

A9-B15-C33; A9-B15-C34; A9-B15-C35; A9-B15-C36; A9-B15-C37; A9-B15-C38;

A9-B15-C39; A9-B15-C40; A9-B15-C41; A9-B15-C42; A9-B15-C43; A9-B15-C44;

A9-B15-C45; A9-B15-C46; A10-B15-Cl; A10-B15-C2; A10-B15-C3; A10-B15-C4;

A10-B15-C5; A10-B15-C6; A10-B15-C7; A10-B15-C8; A10-B15-C9; A10-B15 C10;

A10-B15- A10-B15- A10-B15- A10-B15- A10-B15- A10-B15Cli; C12; C13; C14; C15; C16;

A10-B15- A10-B15- A10-B15- A10-B15- A10-B15- A10-B15C17; C18; C19; C20; C21; C22;

A10-B15- A10-B15- Al0-B15- A10-B15- A10-B15- Al0-B15C23; C24; C25; C26; C27; C28;

A10-B15- A10-B15- A10-B15- A10-B15- A10-B15- A10-B15C29; C30; C31; C32; C33; C34;

A10-B15- A10-B15- A10-B15- A10-B15- A10-B15- A10-B15C35; C36; C37; C38; C39; C40;

A10-B15- A10-B15- A10-B15- A10-B15- A10-B15- A10-B15C41; C42; C43; C44; C45; C46;

All-B15-Cl; All-B15-C2; Ai1-B15-C3; All-B15-C4; All-B15-C5; All-B15-C6;

Ail-B15-C7; All-B15-C8; All-B15-C9; All-B15- All-B15- All-B15 C10; Cil; C12;

All-B15- All-B15- Ali-B15- All-B15- All-B15- Ali-B15C13; C14; C15; C16; C17; C18;

All-B15- All-B15- All-B15- All-B15- All-B15- Ali-B15C19; C20; C21; C22; C23; C24;

All-B15- All-B15- All-B15- All-B15- Ail-B15- Ail-B15C25; C26; C27; C28; C29; C30;

All-B15- All-B15- All-B15- All-B15- All-B15- All-B15C31; C32; C33; C34; C35; C36;

All-B15- All-B15- All-B15- All-B15- All-B15- All-B15C37; C38; C39; C40; C41; C42;

All-B15- All-B15- All-B15- All-B15- A12-B15-Ci; A12-B15-C2;

C43; C44; C45; C46;

A12-B15-C3; A12-B15-C4; A12-B15-C5; A12-B15-C6; A12-B15-C7; A12-B15-C8;

A12-B15-C9; A12-B15- A12-B15- A12-B15- A12-B15- A12-B15C10; C11; C12; C13; C14;

A12-B15- A12-B15- A12-B15- A12-B15- A12-B15- A12-B15 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -107C15; C16; C17; C18; C19; C20;

A12-B15- A12-B15- A12-B15- A12-B15- A12-B15- A12-B15C21; C22; C23; C24; C25; C26;

A12-B15- A12-B15- A12-B15- A12-B15- A12-B15- A12-B15C27; C28; C29; C30; C31; C32;

A12-B15- A12-B15- A12-B15- A12-B15- A12-B15- A12-B15C33; C34; C35; C36; C37; C38;

A12-B15- A12-B15- A12-B15- A12-B15- A12-B15- A12-B15C39; C40; C41; C42; C43; C44;

A12-B15- A12-B15- A13-B15-C1; A13-B15-C2; A13-B15-C3; A13-B15-C4;

C45; C46;

A13-B15-C5; A13-B15-C6; A13-B15-C7; A13-B15-C8; A13-B15-C9; A13-B15C10;

A13-B15- A13-B15- A13-B15- A13-B15- A13-B15- A13-B15Cll; C12; C13; C14; C15; C16;

A13-B15- A13-B15- A13-B15- A13-B15- A13-B15- A13-B15C17; C18; C19; C20; C21; C22;

A13-B15- A13-B15- A13-B15- A13-B15- A13-B15- A13-B15C23; C24; C25; C26; C27; C28;

A13-B15- A13-B15- A13-B15- A13-B15- A13-B15- A13-B15C29; C30; C31; C32; C33; C34;

A13-B15- A13-B15- A13-B15- A13-B15- A13-B15- A13-B15C35; C36; C37; C38; C39; C40;

A13-B15- A13-B15- A13-B15- A13-B15- A13-B15- A13-B15C41; C42; C43; C44; C45; C46;

A14-B15-C1; A14-B15-C2; A14-B15-C3; A14-B15-C4; A14-B15-C5; A14-B15-C6;

A14-B15-C7; A14-B15-C8; A14-B15-C9; A14-B15- A14-B15- A14-B15 C10; Cli; C12;

A14-B15- A14-B15- A14-B15- A14-B15- A14-B15- A14-B15C13; C14; C15; C16; C17; C18;

A14-B15- A14-B15- A14-B15- A14-B15- A14-B15- A14-B15C19; C20; C21; C22; C23; C24;

A14-B15- A14-B15- A14-B15- A14-B15- A14-B15- A14-B15C25; C26; C27; C28; C29; C30;

A14-B15- A14-B15- A14-B15- A14-B15- A14-B15- A14-B15C31; C32; C33; C34; C35; C36;

A14-B15- A14-B15- A14-B15- A14-B15- A14-B15- A14-B15C37; C38; C39; C40; C41; C42;

A14-B15- A14-B15- A14-B15- A14-B15- A15-B15-C1; A15-B15-C2;

C43; C44; C45; C46;

A15-B15-C3; A15-B15-C4; A15-B15-C5; A15-B15-C6; A15-B15-C7; A15-B15-C8;

A15-B15-C9; A15-B15- A15-B15- A15-B15- A15-B15- A15-B15C10; Cli; C12; C13; C14;

A15-B15- A15-B15- A15-B15- A15-B15- A15-B15- A15-B15C15; C16; C17; C18; C19; C20;

A15-B15- A15-B15- A15-B15- A15-B15- A15-B15- A15-B15C21; C22; C23; C24; C25; C26;

A15-B15- A15-B15- A15-B15- A15-B15- A15-B15- A15-B15C27; C28; C29; C30; C31; C32;

A15-B15- A15-B15- A15-B15- A15-B15- A15-B15- A15-B15C33; C34; C35; C36; C37; C38;

A15-B15- A15-B15- A15-B15- A15-B15- A15-B15- A15-B15C39; C40; C41; C42; C43; C44;

A15-B15- A15-B15- A16-B15-Ci; A16-B15-C2; A16-B15-C3; A16-B15-C4;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -108C45; C46;

A16-B15-C5; A16-B15-C6; A16-B15-C7; A16-B15-C8; A16-B15-C9; A16-B15C10;

A16-B15- A16-B15- A16-B15- A16-B15- A16-B15- A16-B15Cll; C12; C13; C14; C15; C16;

A16-B15- A16-B15- A16-B15- A16-B15- A16-B15- A16-B15C17; C18; C19; C20; C21; C22;

A16-B15- A16-B15- A16-B15- A16-B15- A16-B15- A16-B15C23; C24; C25; C26; C27; C28;

A16-B15- A16-B15- A16-B15- A16-B15- A16-B15- A16-B15C29; C30; C31; C32; C33; C34;

A16-B15- A16-B15- A16-B15- A16-B15- A16-B15- A16-B15C35; C36; C37; C38; C39; C40;

A16-B15- A16-B15- A16-B15- A16-B15- A16-B15- A16-B15C41; C42; C43; C44; C45; C46;

A17-B15-C1; A17-B15-C2; A17-B15-C3; A17-B15-C4; A17-B15-C5; A17-B15-C6;

A17-B15-C7; A17-B15-C8; A17-B15-C9; A17-B15- A17-B15- A17-B15 C10; Cll; C12;

A17-B15- A17-B15- A17-B15- A17-B15- A17-B15- A17-B15C13; C14; C15; C16; C17; C18;

A17-B15- A17-B15- A17-B15- A17-B15- A17-B15- A17-B15C19; C20; C21; C22; C23; C24;

A17-B15- A17-B15- A17-B15- A17-B15- A17-B15- A17-B15C25; C26; C27; C28; C29; C30;

A17-B15- A17-B15- A17-B15- A17-B15- A17-B15- A17-B15C31; C32; C33; C34; C35; C36;

A17-B15- A17-B15- A17-B15- A17-B15- A17-B15- A17-B15C37; C38; C39; C40; C41; C42;

A17-B15- A17-B15- A17-B15- A17-B15- A18-B15-C1; A18-B15-C2;

C43; C44; C45; C46;

A18-B15-C3; A18-B15-C4; A18-B15-C5; A18-B15-C6; A18-B15-C7; A18-B15-C8;

A18-B15-C9; A18-B15- A18-B15- A18-B15- A18-B15- A18-B15C10; C11; C12; C13; C14;

A18-B15- A18-B15- A18-B15- A18-B15- A18-B15- A18-B15C15; C16; C17; C18; C19; C20;

A18-B15- A18-B15- A18-B15- A18-B15- A18-B15- A18-B15C21; C22; C23; C24; C25; C26;

A18-B15- A18-B15- A18-B15- A18-B15- A18-B15- A18-B15C27; C28; C29; C30; C31; C32;

A18-B15- A18-B15- A18-B15- A18-B15- A18-B15- A18-B15C33; C34; C35; C36; C37; C38;

A18-B15- A18-B15- A18-B15- A18-B15- A18-B15- A18-B15C39; C40; C41; C42; C43; C44;

A18-B15- A18-B15- A19-B15-Cl; A19-B15-C2; A19-B15-C3; A19-B15-C4;

C45; C46;

A19-B15-C5; A19-B15-C6; A19-B15-C7; A19-B15-C8; A19-B15-C9; A19-B15C10;

A19-B15- A19-B15- A19-B15- A19-B15- A19-B15- A19-B15Cll; C12; C13; C14; C15; C16;

A19-B15- A19-B15- A19-B15- A19-B15- A19-B15- A19-B15C17; C18; C19; C20; C21; C22;

A19-B15- A19-B15- A19-B15- A19-B15- A19-B15- A19-B15C23; C24; C25; C26; C27; C28;

A19-B15- A19-B15- A19-B15- A19-B15- A19-B15- A19-B15 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -109C29; C30; C31; C32; C33; C34;

A19-B15- A19-B15- A19-B15- A19-B15- A19-B15- A19-B15C35; C36; C37; C38; C39; C40;

A19-B15- A19-B15- A19-B15- A19-B15- A19-B15- A19-B15C41; C42; C43; C44; C45; C46;

A20-B15-Cl; A20-B15-C2; A20-B15-C3; A20-B15-C4; A20-B15-C5; A20-B15-C6;

A20-B15-C7; A20-B15-C8; A20-B15-C9; A20-B15- A20-B15- A20-B15 C10; Cll; C12;

A20-B15- A20-B15- A20-B15- A20-B15- A20-B15- A20-B15C13; C14; C15; C16; C17; C18;

A20-B15- A20-B15- A20-B15- A20-B15- A20-B15- A20-B15C19; C20; C21; C22; C23; C24;

A20-B15- A20-B15- A20-B15- A20-B15- A20-B15- A20-B15C25; C26; C27; C28; C29; C30;

A20-B15- A20-B15- A20-B15- A20-B15- A20-B15- A20-B15C31; C32; C33; C34; C35; C36;

A20-B15- A20-B15- A20-B15- A20-B15- A20-B15- A20-B15C37; C38; C39; C40; C41; C42;

A20-B15- A20-B15- A20-B15- A20-B15- A21-B15-C1; A21-B15-C2;

C43; C44; C45; C46;

A21-B15-C3; A21-B15-C4; A21-B15-C5; A21-B15-C6; A21-B15-C7; A21-B15-C8;

A21-B15-C9; A21-B15- A21-B15- A21-B15- A21-B15- A21-B15C10; Cli; C12; C13; C14;

A21-B15- A21-B15- A21-B15- A21-B15- A21-B15- A21-B15C15; C16; C17; C18; C19; C20;

A21-B15- A21-B15- A21-B15- A21-B15- A21-B15- A21-B15C21; C22; C23; C24; C25; C26;

A21-B15- A21-B15- A21-B15- A21-B15- A21-B15- A21-B15C27; C28; C29; C30; C31; C32;

A21-B15- A21-B15- A21-B15- A21-B15- A21-B15- A21-B15C33; C34; C35; C36; C37; C38;

A21-B15- A21-B15- A21-B15- A21-B15- A21-B15- A21-B15C39; C40; C41; C42; C43; C44;

A21-B15- A21-B15- A22-B15-Cl; A22-B15-C2; A22-B15-C3; A22-B15-C4;

C45; C46;

A22-B15-C5; A22-B15-C6; A22-B15-C7; A22-B15-C8; A22-B15-C9; A22-B15C10;

A22-B15- A22-B15- A22-B15- A22-B15- A22-B15- A22-B15Cli; C12; C13; C14; C15; C16;

A22-B15- A22-B15- A22-B15- A22-B15- A22-B15- A22-B15C17; C18; C19; C20; C21; C22;

A22-B15- A22-B15- A22-B15- A22-B15- A22-B15- A22-B15C23; C24; C25; C26; C27; C28;

A22-B15- A22-B15- A22-B15- A22-B15- A22-B15- A22-B15C29; C30; C31; C32; C33; C34;

A22-B15- A22-B15- A22-B15- A22-B15- A22-B15- A22-B15C35; C36; C37; C38; C39; C40;

A22-B15- A22-B15- A22-B15- A22-B15- A22-B15- A22-B15C41; C42; C43; C44; C45; C46;

A23-B15-Cl; A23-B15-C2; A23-B15-C3; A23-B15-C4; A23-B15-C5; A23-B15-C6;

A23-B15-C7; A23-B15-C8; A23-B15-C9; A23-B15- A23-B15- A23-B15 C10; Cli; C12;

A23-B15- A23-B15- A23-B15- A23-B15- A23-B15- A23-B15C13; C14; C15; C16; C17; C18;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -110A23-B15- A23-B15- A23-B15- A23-B15- A23-B15- A23-B15C19; C20; C21; C22; C23; C24;

A23-B15- A23-B15- A23-B15- A23-B15- A23-B15- A23-B15C25; C26; C27; C28; C29; C30;

A23-B15- A23-B15- A23-B15- A23-B15- A23-B15- A23-B15C31; C32; C33; C34; C35; C36;

A23-B15- A23-B15- A23-B15- A23-B15- A23-B15- A23-B15C37; C38; C39; C40; C41; C42;

A23-B15- A23-B15- A23-B15- A23-B15- A24-B15-Cl; A24-B15-C2;

C43; C44; C45; C46;

A24-B15-C3; A24-B15-C4; A24-B15-C5; A24-B15-C6; A24-B15-C7; A24-B15-C8;

A24-B15-C9; A24-B15- A24-B15- A24-B15- A24-B15- A24-B15C10; Cll; C12; C13; C14;

A24-B15- A24-B15- A24-B15- A24-B15- A24-B15- A24-B15C15; C16; C17; C18; C19; C20;

A24-B15- A24-B15- A24-B15- A24-B15- A24-B15- A24-B15C21; C22; C23; C24; C25; C26;

A24-B15- A24-B15- A24-B15- A24-B15- A24-B15- A24-B15C27; C28; C29; C30; C31; C32;

A24-B15- A24-B15- A24-B15- A24-B15- A24-B15- A24-B15C33; C34; C35; C36; C37; C38;

A24-B15- A24-B15- A24-B15- A24-B15- A24-B15- A24-B15C39; C40; C41; C42; C43; C44;

A24-B15- A24-B15- A25-B15-C1; A25-B15-C2; A25-B15-C3; A25-B15-C4;

C45; C46;

A25-B15-C5; A25-B15-C6; A25-B15-C7; A25-B15-C8; A25-B15-C9; A25-B15C10;

A25-B15- A25-B15- A25-B15- A25-B15- A25-B15- A25-B15Cll; C12; C13; C14; C15; C16;

A25-B15- A25-B15- A25-B15- A25-B15- A25-B15- A25-B15C17; C18; C19; C20; C21; C22;

A25-B15- A25-B15- A25-B15- A25-B15- A25-B15- A25-B15C23; C24; C25; C26; C27; C28;

A25-B15- A25-B15- A25-B15- A25-B15- A25-B15- A25-B15C29; C30; C31; C32; C33; C34;

A25-B15- A25-B15- A25-B15- A25-B15- A25-B15- A25-B15C35; C36; C37; C38; C39; C40;

A25-B15- A25-B15- A25-B15- A25-B15- A25-B15- A25-B15C41; C42; C43; C44; C45; C46;

A26-B15-C1; A26-B15-C2; A26-B15-C3; A26-B15-C4; A26-B15-C5; A26-B15-C6;

A26-B15-C7; A26-B15-C8; A26-B15-C9; A26-B15- A26-B15- A26-B15 C10; Cll; C12;

A26-B15- A26-B15- A26-B15- A26-B15- A26-B15- A26-B15C13; C14; C15; C16; C17; C18;

A26-B15- A26-B15- A26-B15- A26-B15- A26-B15- A26-B15C19; C20; C21; C22; C23; C24;

A26-B15- A26-B15- A26-B15- A26-B15- A26-B15- A26-B15C25; C26; C27; C28; C29; C30;

A26-B15- A26-B15- A26-B15- A26-B15- A26-B15- A26-B15C31; C32; C33; C34; C35; C36;

A26-B15- A26-B15- A26-B15- A26-B15- A26-B15- A26-B15C37; C38; C39; C40; C41; C42;

A26-B15- A26-B15- A26-B15- A26-B15- A27-B15-Cl; A27-B15-C2;

C43; C44; C45; C46;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -111A27-B15-C3; A27-B15-C4; A27-B15-C5; A27-B15-C6; A27-B15-C7; A27-B15-C8;

A27-B15-C9; A27-B15- A27-B15- A27-B15- A27-B15- A27-B15 C10; Cll; C12; C13; C14;

A27-B15- A27-B15- A27-B15- A27-B15- A27-B15- A27-B15C15; C16; C17; C18; C19; C20;

A27-B15- A27-B15- A27-B15- A27-B15- A27-B15- A27-B15C21; C22; C23; C24; C25; C26;

A27-B15- A27-B15- A27-B15- A27-B15- A27-B15- A27-B15C27; C28; C29; C30; C31; C32;

A27-B15- A27-B15- A27-B15- A27-B15- A27-B15- A27-B15C33; C34; C35; C36; C37; C38;

A27-B15- A27-B15- A27-B15- A27-B15- A27-B15- A27-B15C39; C40; C41; C42; C43; C44;

A27-B15- A27-B15- A28-B15-Cl; A28-B15-C2; A28-B15-C3; A28-B15-C4;

C45; C46;

A28-B15-C5; A28-B15-C6; A28-B15-C7; A28-B15-C8; A28-B15-C9; A28-B15C10;

A28-B15- A28-B15- A28-B15- A28-B15- A28-B15- A28-B15Cll; C12; C13; C14; C15; C16;

A28-B15- A28-B15- A28-B15- A28-B15- A28-B15- A28-B15C17; C18; C19; C20; C21; C22;

A28-B15- A28-B15- A28-B15- A28-B15- A28-B15- A28-B15C23; C24; C25; C26; C27; C28;

A28-B15- A28-B15- A28-B15- A28-B15- A28-B15- A28-B15C29; C30; C31; C32; C33; C34;

A28-B15- A28-B15- A28-B15- A28-B15- A28-B15- A28-B15C35; C36; C37; C38; C39; C40;

A28-B15- A28-B15- A28-B15- A28-B15- A28-B15- A28-B15C41; C42; C43; C44; C45; C46;

Al-B16-Cl; Al-B16-C2; Al-B16-C3; Al-B16-C4; Al-B16-C5; Al-B16-C6;

Al-B16-C7; Al-B16-C8; Al-B16-C9; Al-B16-C10; Al-B16-Cll; Al-B16-C12;

Al-B16-C13; Al-B16-C14; Al-B16-C15; Al-B16-C16; Al-B16-C17; Al-B16-C18;

Al-B16-C19; Al-B16-C20; Al-B16-C21; Al-B16-C22; Al-B16-C23; Al-B16-C24;

Al-B16-C25; Al-B16-C26; Al-B16-C27; Al-B16-C28; Al-B16-C29; Al-B16-C30;

Al-B16-C31; Al-B16-C32; Al-B16-C33; Al-B16-C34; Al-B16-C35; Al-B16-C36;

Al-B16-C37; Al-B16-C38; Al-B16-C39; Al-B16-C40; Al-B16-C41; Al-B16-C42;

Al-Bi6-C43; Al-B16-C44; Al-B16-C45; Al-B16-C46; A2-B16-Cl; A2-B16-C2;

A2-B16-C3; A2-B16-C4; A2-B16-C5; A2-B16-C6; A2-B16-C7; A2-B16-C8;

A2-B16-C9; A2-B16-C10; A2-B16-Cll; A2-B16-C12; A2-B16-C13; A2-B16-C14;

A2-B16-C15; A2-B16-C16; A2-B16-Ci7; A2-B16-C18; A2-B16-C19; A2-B16-C20;

A2-B16-C21; A2-B16-C22; A2-B16-C23; A2-B16-C24; A2-B16-C25; A2-B16-C26;

A2-B16-C27; A2-B16-C28; A2-B16-C29; A2-B16-C30; A2-B16-C31; A2-Bi6-C32;

A2-B16-C33; A2-B16-C34; A2-B16-C35; A2-B16-C36; A2-B16-C37; A2-B16-C38;

A2-B16-C39; A2-B16-C40; A2-B16-C41; A2-B16-C42; A2-B16-C43; A2-B16-C44;

A2-B16-C45; A2-B16-C46; A3-B16-Cl; A3-B16-C2; A3-B16-C3; A3-B16-C4;

A3-B16-C5; A3-Bi6-C6; A3-Bl6-C7; A3-Bi6-C8; A3-B16-C9; A3-B16-Cl0;

A3-B16-Cll; A3-B16-C12; A3-B16-C13; A3-B16-Ci4; A3-B16-C15; A3-B16-C16;

A3-B16-C17; A3-B16-C18; A3-B16-C19; A3-B16-C20; A3-B16-C21; A3-Bi6-C22;

A3-B16-C23; A3-B16-C24; A3-Bi6-C25; A3-B16-C26; A3-B16-C27; A3-B16-C28;

A3-B16-C29; A3-B16-C30; A3-B16-C31; A3-B16-C32; A3-B16-C33; A3-B16-C34;

A3-Bi6-C35; A3-B16-C36; A3-B16-C37; A3-B16-C38; A3-B16-C39; A3-B16-C40;

A3-B16-C41; A3-B16-C42; A3-B16-C43; A3-B16-C44; A3-B16-C45; A3-B16-C46;

A4-Bi6-Cl; A4-B16-C2; A4-B16-C3; A4-Bi6-C4; A4-B16-C5; A4-B16-C6;

A4-Bi6-C7; A4-Bl6-C8; A4-Bi6-C9; A4-B16-Cl0; A4-B16-Cll; A4-B16-C12;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -112A4-B16-C13; A4-B16-C14; A4-B16-C15; A4-B16-C16; A4-B16-C17; A4-B16-C18;

A4-B16-C19; A4-B16-C20; A4-B16-C21; A4-B16-C22; A4-B16-C23; A4-B16-C24;

A4-B16-C25; A4-B16-C26; A4-B16-C27; A4-B16-C28; A4-B16-C29; A4-B16-C30;

A4-B16-C31; A4-B16-C32; A4-B16-C33; A4-B16-C34; A4-B16-C35; A4-B16-C36;

A4-B16-C37; A4-B16-C38; A4-B16-C39; A4-B16-C40; A4-B16-C41; A4-B16-C42;

A4-B16-C43; A4-B16-C44; A4-B16-C45; A4-B16-C46; A5-B16-C1; A5-B16-C2;

A5-B16-C3; A5-B16-C4; A5-B16-C5; A5-B16-C6; A5-B16-C7; A5-B16-C8;

A5-B16-C9; A5-B16-C10; A5-B16-C11; A5-B16-C12; A5-B16-C13; A5-B16-C14;

A5-B16-C15; A5-B16-C16; A5-B16-C17; A5-B16-C18; A5-B16-C19; A5-B16-C20;

A5-B16-C21; A5-B16-C22; A5-B16-C23; A5-B16-C24; A5-B16-C25; A5-B16-C26;

A5-B16-C27; A5-B16-C28; A5-B16-C29; A5-B16-C30; A5-B16-C31; A5-B16-C32;

A5-B16-C33; A5-B16-C34; A5-B16-C35; A5-B16-C36; A5-B16-C37; A5-B16-C38;

A5-B16-C39; A5-B16-C40; A5-B16-C41; A5-B16-C42; A5-B16-C43; A5-B16-C44;

A5-B16-C45; A5-B16-C46; A6-B16-C1; A6-B16-C2; A6-B16-C3; A6-B16-C4;

A6-B16-C5; A6-B16-C6; A6-B16-C7; A6-B16-C8; A6-B16-C9; A6-B16-C10;

A6-B16-Cll; A6-B16-C12; A6-B16-C13; A6-B16-C14; A6-B16-C15; A6-B16-C16;

A6-B16-C17; A6-B16-C18; A6-B16-C19; A6-B16-C20; A6-B16-C21; A6-B16-C22;

A6-B16-C23; A6-B16-C24; A6-B16-C25; A6-B16-C26; A6-B16-C27; A6-B16-C28;

A6-B16-C29; A6-B16-C30; A6-B16-C31; A6-B16-C32; A6-B16-C33; A6-B16-C34;

A6-B16-C35; A6-B16-C36; A6-B16-C37; A6-B16-C38; A6-B16-C39; A6-B16-C40;

A6-B16-C41; A6-B16-C42; A6-B16-C43; A6-B16-C44; A6-B16-C45; A6-B16-C46;

A7-B16-Cl; A7-B16-C2; A7-B16-C3; A7-B16-C4; A7-B16-C5; A7-B16-C6;

A7-B16-C7; A7-B16-C8; A7-B16-C9; A7-B16-C10; A7-B16-C11; A7-B16-C12;

A7-B16-C13; A7-B16-C14; A7-B16-C15; A7-B16-C16; A7-B16-C17; A7-B16-C18;

A7-B16-C19; A7-B16-C20; A7-B16-C21; A7-B16-C22; A7-B16-C23; A7-B16-C24;

A7-B16-C25; A7-B16-C26; A7-B16-C27; A7-B16-C28; A7-B16-C29; A7-B16-C30;

A7-B16-C31; A7-B16-C32; A7-B16-C33; A7-B16-C34; A7-B16-C35; A7-B16-C36;

A7-B16-C37; A7-B16-C38; A7-B16-C39; A7-B16-C40; A7-B16-C41; A7-B16-C42;

A7-B16-C43; A7-B16-C44; A7-B16-C45; A7-B16-C46; A8-B16-C1; A8-B16-C2;

A8-B16-C3; A8-B16-C4; A8-B16-C5; A8-B16-C6; A8-B16-C7; A8-B16-C8;

A8-B16-C9; A8-B16-C10; A8-B16-Cll; A8-B16-C12; A8-B16-C13; A8-B16-C14;

A8-B16-C15; A8-B16-C16; A8-B16-C17; A8-B16-C18; A8-B16-C19; A8-B16-C20;

A8-B16-C21; A8-B16-C22; A8-B16-C23; A8-B16-C24; A8-B16-C25; A8-B16-C26;

A8-B16-C27; A8-B16-C28; A8-B16-C29; A8-B16-C30; A8-B16-C31; A8-B16-C32;

A8-B16-C33; A8-B16-C34; A8-B16-C35; A8-B16-C36; A8-B16-C37; A8-B16-C38;

A8-B16-C39; A8-B16-C40; A8-B16-C41; A8-B16-C42; A8-B16-C43; A8-B16-C44;

A8-B16-C45; A8-B16-C46; A9-B16-C1; A9-B16-C2; A9-B16-C3; A9-B16-C4;

A9-B16-C5; A9-B16-C6; A9-B16-C7; A9-B16-C8; A9-B16-C9; A9-B16-C10;

A9-B16-C11; A9-B16-C12; A9-B16-C13; A9-B16-C14; A9-B16-C15; A9-B16-C16;

A9-B16-C17; A9-B16-C18; A9-B16-C19; A9-B16-C20; A9-B16-C21; A9-B16-C22;

A9-B16-C23; A9-B16-C24; A9-B16-C25; A9-B16-C26; A9-B16-C27; A9-B16-C28;

A9-B16-C29; A9-B16-C30; A9-B16-C31; A9-B16-C32; A9-B16-C33; A9-B16-C34;

A9-B16-C35; A9-B16-C36; A9-B16-C37; A9-B16-C38; A9-B16-C39; A9-B16-C40;

A9-B16-C41; A9-B16-C42; A9-B16-C43; A9-B16-C44; A9-B16-C45; A9-B16-C46;

A10-B16-Cl; A10-B16-C2; A10-B16-C3; A10-B16-C4; A10-B16-C5; A10-B16-C6;

A10-B16-C7; A10-B16-C8; A10-B16-C9; A10-B16- A10-B16- A10-B16 C10; Cll; C12;

A10-B16- A10-B16- A10-B16- A10-B16- A10-B16- A10-B16C13; C14; C15; C16; C17; C18;

A10-B16- A10-B16- A10-B16- A10-B16- A10-B16- A10-B16C19; C20; C21; C22; C23; C24;

A10-B16- A10-B16- A10-B16- A10-B16- A10-B16- A10-B16C25; C26; C27; C28; C29; C30;

A10-B16- A10-B16- A10-B16- A10-B16- A10-B16- A10-B16 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -113C31; C32; C33; C34; C35; C36;

A10-B16- A10-B16- A10-B16- A10-B16- A10-B16- A10-B16C37; C38; C39; C40; C41; C42;

A10-B16- A10-B16- A10-B16- A10-B16- A11-B16-Cl; All-B16-C2;

C43; C44; C45; C46;

All-B16-C3; All-B16-C4; All-B16-C5; All-B16-C6; All-B16-C7; A11-B16-C8;

All-B16-C9; All-B16- All-B16- All-B16- All-B1'6- A11-B16C10; Cll; C12; C13; C14;

All-B16- All-B16- All-B16- All-B16- All-B16- All-B16C15; C16; C17; C18; C19; C20;

All-B16- All-B16- All-B16- All-B16- All-B16- All-B16C21; C22; C23; C24; C25; C26;

All-B16- All-B16- All-B16- All-B16- All-B16- All-B16C27; C28; C29; C30; C31; C32;

All-B16- All-B16- All-B16- All-B16- All-B16- All-B16C33; C34; C35; C36; C37; C38;

All-B16- All-B16- All-B16- All-B16- All-B16- All-B16C39; C40; C41; C42; C43; C44;

All-B16- All-B16- A12-B16-Cl; A12-B16-C2; A12-B16-C3; A12-B16-C4;

C45; C46;

A12-B16-C5; A12-B16-C6; A12-B16-C7; A12-B16-C8; A12-B16-C9; A12-B16C10;

A12-B16- A12-B16- A12-B16- A12-B16- A12-B16- A12-B16Cll; C12; C13; C14; C15; C16;

A12-B16- A12-B16- A12-B16- A12-B16- A12-B16- A12-B16C17; C18; C19; C20; C21; C22;

A12-B16- A12-B16- A12-B16- A12-B16- A12-B16- A12-B16C23; C24; C25; C26; C27; C28;

A12-B16- A12-B16- A12-B16- A12-B16- A12-B16- A12-B16C29; C30; C31; C32; C33; C34;

A12-B16- A12-B16- A12-B16- A12-B16- A12-B16- A12-B16C35; C36; C37; C38; C39; C40;

A12-B16- A12-B16- A12-B16- A12-B16- A12-B16- A12-B16C41; C42; C43; C44; C45; C46;

A13-B16-C1; A13-B16-C2; A13-B16-C3; A13-B16-C4; A13-B16-C5; A13-B16-C6;

A13-B16-C7; A13-B16-C8; A13-B16-C9; A13-B16- A13-B16- A13-B16 C10; Cll; C12;

A13-B16- A13-B16- A13-B16- A13-B16- A13-B16- A13-B16C13; C14; C15; C16; C17; C18;

A13-B16- A13-B16- A13-B16- A13-B16- A13-B16- A13-B16C19; C20; C21; C22; C23; C24;

A13-B16- A13-B16- A13-B16- A13-B16- A13-B16- A13-B16C25; C26; C27; C28; C29; C30;

A13-B16- A13-B16- A13-B16- A13-B16- A13-B16- A13-B16C31; C32; C33; C34; C35; C36;

A13-B16- A13-B16- A13-B16- A13-B16- A13-B16- A13-B16C37; C38; C39; C40; C41; C42;

A13-B16- A13-B16- A13-B16- A13-B16- A14-B16-Cl; A14-B16-C2;

C43; C44; C45; C46;

A14-B16-C3; A14-B16-C4; A14-B16-C5; A14-B16-C6; A14-B16-C7; A14-B16-C8;

A14-B16-C9; A14-B16- A14-B16- A14-B16- A14-B16- A14-B16C10; Cll; C12; C13; C14;

A14-B16- A14-B16- A14-B16- A14-B16- A14-B16- A14-B16C15; C16; C17; C18; C19; C20;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -114A14-B16- A14-B16- A14-B16- A14-B16- A14-B16- A14-B16C21; C22; C23; C24; C25; C26;

A14-B16- A14-B16- A14-B16- A14-B16- A14-B16- A14-B16C27; C28; C29; C30; C31; C32;

A14-B16- A14-B16- A14-B16- A14-B16- A14-B16- A14-B16C33; C34; C35; C36; C37; C38;

A14-B16- A14-B16- A14-B16- A14-B16- A14-B16- A14-B16C39; C40; C41; C42; C43; C44;

A14-B16- A14-B16- A15-B16-C1; A15-B16-C2; A15-B16-C3; A15-B16-C4;

C45; C46;

A15-B16-C5; A15-B16-C6; A15-B16-C7; A15-B16-C8; A15-B16-C9; A15-B16C10;

A15-B16- A15-B16- A15-B16- A15-B16- A15-B16- A15-B16C11; C12; C13; C14; C15; C16;

A15-B16- A15-B16- A15-B16- A15-B16- A15-B16- A15-B16C17; C18; C19; C20; C21; C22;

A15-B16- A15-B16- A15-B16- A15-B16- A15-B16- A15-B16C23; C24; C25; C26; C27; C28;

A15-B16- A15-B16- A15-B16- A15-B16- A15-B16- A15-B16C29; C30; C31; C32; C33; C34;

A15-B16- A15-B16- A15-B16- A15-B16- A15-B16- A15-B16C35; C36; C37; C38; C39; C40;

A15-B16- A15-B16- A15-B16- A15-B16- A15-B16- A15-B16C41; C42; C43; C44; C45; C46;

A16-B16-Cl; A16-B16-C2; A16-B16-C3; A16-B16-C4; A16-B16-C5; A16-B16-C6;

A16-B16-C7; A16-B16-C8; A16-B16-C9; A16-B16- A16-B16- A16-B16 C10; Cii; C12;

A16-B16- A16-B16- A16-B16- A16-B16- A16-B16- A16-B16C13; C14; C15; C16; C17; C18;

A16-B16- A16-B16- A16-B16- A16-B16- A16-B16- A16-B16C19; C20; C21; C22; C23; C24;

A16-B16- A16-B16- A16-B16- A16-B16- A16-B16- A16-B16C25; C26; C27; C28; C29; C30;

A16-B16- A16-B16- A16-B16- A16-B16- A16-B16- A16-B16C31; C32; C33; C34; C35; C36;

A16-B16- A16-B16- A16-B16- A16-B16- A16-B16- A16-B16C37; C38; C39; C40; C41; C42;

A16-B16- A16-B16- A16-B16- A16-B16- A17-B16-Cl; A17-B16-C2;

C43; C44; C45; C46;

A17-B16-C3; A17-B16-C4; A17-B16-C5; A17-B16-C6; A17-B16-C7; A17-B16-C8;

A17-B16-C9; A17-B16- A17-B16- A17-B16- A17-B16- A17-B16C10; Cll; C12; C13; C14;

A17-B16- A17-B16- A17-B16- A17-B16- A17-B16- A17-B16C15; C16; C17; C18; C19; C20;

A17-B16- A17-B16- A17-B16- A17-B16- A17-B16- A17-B16C21; C22; C23; C24; C25; C26;

A17-B16- A17-B16- A17-B16- A17-B16- A17-B16- A17-B16C27; C28; C29; C30; C31; C32;

A17-B16- A17-B16- A17-B16- A17-B16- A17-B16- A17-B16C33; C34; C35; C36; C37; C38;

A17-B16- A17-B16- A17-B16- A17-B16- A17-B16- A17-B16C39; C40; C41; C42; C43; C44;

A17-B16- A17-B16- A18-B16-Cl; A18-B16-C2; A18-B16-C3; A18-B16-C4;

C45; C46;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -115A18-B16-C5; A18-B16-C6; A18-B16-C7; A18-B16-C8; A18-B16-C9; A18-B16 C10;

A18-B16- A18-B16- A18-B16- A18-B16- A18-B16- A18-B16Cl l; C12; C13; C14; C15; C16;

A18-B16- A18-1116- A18-B16- A18-B16- A18-B16- A18-B16C17; C18; C19; C20; C21; C22;

A18-B16- A18-B16- A18-B16- A18-B16- A18-B16- A18-B16C23; C24; C25; C26; C27; C28;

A18-B16- A18-B16- A18-B16- A18-B16- A18-B16- A18-B16C29; C30; C31; C32; C33; C34;

A18-B16- A18-B16- A18-B16- A18-B16- A18-B16- A18-B16C35; C36; C37; C38; C39; C40;

A18-B16- A18-B16- A18-B16- A18-B16- A18-B16- A18-B16C41; C42; C43; C44; C45; C46;

A19-B16-Cl; A19-B16-C2; A19-B16-C3; A19-B16-C4; A19-B16-C5; A19-B16-C6;

A19-B16-C7; A19-B16-C8; A19-B16-C9; A19-B16- A19-B16- A19-B16 C10; C11; C12;

A19-B16- A19-B16- A19-B16- A19-B16- A19-B16- A19-B16C13; C14; C15; C16; C17; C18;

A19-B16- A19-B16- A19-B16- A19-B16- A19-B16- A19-B16C19; C20; C21; C22; C23; C24;

A19-B16- A19-1116- A19-B16- A19-B16- A19-B16- A19-B16C25; C26; C27; C28; C29; C30;

A19-B16- A19-B16- A19-B16- A19-B16- A19-B16- A19-B16C31; C32; C33; C34; C35; C36;

A19-B16- A19-B16- A19-B16- A19-B16- A19-B16- A19-B16C37; C38; C39; C40; C41; C42;

A19-B16- A19-B16- A19-B16- A19-B16- A20-B16-C1; A20-B16-C2;

C43; C44; C45; C46;

A20-B16-C3; A20-B16-C4; A20-B16-C5; A20-B16-C6; A20-B16-C7; A20-B16-C8;

A20-B16-C9; A20-1316- A20-B16- A20-B16- A20-B16- A20-B16C10; C11; C12; C13; C14;

A20-B16- A20-B16- A20-B16- A20-B16- A20-B16- A20-B16C15; C16; C17; C18; C19; C20;

A20-B16- A20-B16- A20-B16- A20-B16- A20-B16- A20-B16C21; C22; C23; C24; C25; C26;

A20-B16- A20-1316- A20-B16- A20-B16- A20-B16- A20-B16C27; C28; C29; C30; C31; C32;

A20-B16- A20-B16- A20-B16- A20-B16- A20-B16- A20-B16C33; C34; C35; C36; C37; C38;

A20-B16- A20-1316- A20-B16- A20-B16- A20-B16- A20-B16C39; C40; C41; C42; C43; C44;

A20-B16- A20-B16- A21-B16-Cl; A21-B16-C2; A21-B16-C3; A21-B16-C4;

C45; C46;

A21-B16-C5; A21-B16-C6; A21-B16-C7; A21-B16-C8; A21-B16-C9; A21-B16C10;

A21-B16- A21-B16- A21-B16- A21-B16- A21-B16- A21-B16C11; C12; C13; C14; C15; C16;

A21-B16- A21-B16- A21-B16- A21-B16- A21-B16- A21-B16C17; C18; C19; C20; C21; C22;

A21-B16- A21-B16- A21-B16- A21-B16- A21-B16- A21-B16C23; C24; C25; C26; C27; C28;

A21-B16- A21-B16- A21-B16- A21-B16- A21-B16- A21-B16C29; C30; C31; C32; C33; C34;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -116A21-B16- A21-B16- A21-B16- A21-B16- A21-B16- A21-B16C35; C36; C37; C38; C39; C40;

A21-B16- A21-B16- A21-B16- A21-B16- A21-B16- A21-B16C41; C42; C43; C44; C45; C46;

A22-B16-Cl; A22-B16-C2; A22-B16-C3; A22-B16-C4; A22-B16-C5; A22-B16-C6;

A22-B16-C7; A22-B16-C8; A22-B16-C9; A22-B16- A22-B16- A22-B16 C10; C11; C12;

A22-B16- A22-B16- A22-B16- A22-B16- A22-B16- A22-B16C13; C14; C15; C16; C17; C18;

A22-B16- A22-B16- A22-B16- A22-B16- A22-B16- A22-B16C19; C20; C21; C22; C23; C24;

A22-B16- A22-B16- A22-B16- A22-B16- A22-B16- A22-B16C25; C26; C27; C28; C29; C30;

A22-B16- A22-B16- A22-B16- A22-B16- A22-B16- A22-B16C31; C32; C33; C34; C35; C36;

A22-B16- A22-B16- A22-B16- A22-B16- A22-B16- A22-B16C37; C38; C39; C40; C41; C42;

A22-B16- A22-B16- A22-B16- A22-B16- A23-B16-Ci; A23-B16-C2;

C43; C44; C45; C46;

A23-B16-C3; A23-B16-C4; A23-B16-C5; A23-B16-C6; A23-B16-C7; A23-B16-C8;

A23-B16-C9; A23-B16- A23-B16- A23-B16- A23-B16- A23-B16C10; Cll; C12; C13;~ C14;

A23-B16- A23-B16- A23-B16- A23-B16- A23-B16- A23-B16C15; C16; C17; C18; C19; C20;

A23-B16- A23-B16- A23-B16- A23-B16- A23-B16- A23-B16C21; C22; C23; C24; C25; C26;

A23-B16- A23-B16- A23-B16- A23-B16- A23-B16- A23-B16C27; C28; C29; C30; C31; C32;

A23-B16- A23-B16- A23-B16- A23-B16- A23-B16- A23-B16C33; C34; C35; C36; C37; C38;

A23-B16- A23-B16- A23-B16- A23-B16- A23-B16- A23-B16C39; C40; C41; C42; C43; C44;

A23-B16- A23-B16- A24-B16-Cl; A24-B16-C2; A24-B16-C3; A24-B16-C4;

C45; C46;

A24-B16-C5; A24-B16-C6; A24-B16-C7; A24-B16-C8; A24-B16-C9; A24-B16C10;

A24-B16- A24-B16- A24-B16- A24-B16- A24-B16- A24-B16Cll; C12; C13; C14; C15; C16;

A24-B16- A24-B16- A24-B16- A24-B16- A24-B16- A24-B16C17; C18; C19; C20; C21; C22;

A24-B16- A24-B16- A24-B16- A24-B16- A24-B16- A24-B16C23; C24; C25; C26; C27; C28;

A24-B16- A24-B16- A24-B16- A24-B16- A24-B16- A24-B16C29; C30; C31; C32; C33; C34;

A24-B16- A24-B16- A24-B16- A24-B16- A24-B16- A24-B16C35; C36; C37; C38; C39; C40;

A24-B16- A24-B16- A24-B16- A24-B16- A24-B16- A24-B16C41; C42; C43; C44; C45; C46;

A25-B16-C1; A25-B16-C2; A25-B16-C3; A25-B16-C4; A25-B16-C5; A25-B16-C6;

A25-B16-C7; A25-B16-C8; A25-B16-C9; A25-B16- A25-B16- A25-B16 C10; Cli; C12;

A25-B16- A25-B16- A25-B16- A25-B16- A25-B16- A25-B16C13; C14; C15; C16; C17; C18;

A25-B16- A25-B16- A25-B16- A25-B16- A25-B16- A25-B16 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -117C19; C20; C21; C22; C23; C24;

A25-B16- A25-B16- A25-B16- A25-B16- A25-B16- A25-B16C25; C26; C27; C28; C29; C30;

A25-B16- A25-B16- A25-B16- A25-B16- A25-B16- A25-B16C31; C32; C33; C34; C35; C36;

A25-B16- A25-B16- A25-B16- A25-B16- A25-B16- A25-B16C37; C38; C39; C40; C41; C42;

A25-B16- A25-B16- A25-B16- A25-B16- A26-B16-Cl; A26-B16-C2;

C43; C44; C45; C46;

A26-B16-C3; A26-B16-C4; A26-B16-C5; A26-B16-C6; A26-B16-C7; A26-B16-C8;

A26-B16-C9; A26-B16- A26-B16- A26-B16- A26-B16- A26-B16C10; C11; C12; C13; C14;

A26-B16- A26-B16- A26-B16- A26-B16- A26-B16- A26-B16C15; C16; C17; C18; C19; C20;

A26-B16- A26-B16- A26-B16- A26-B16- A26-B16- A26-B16C21; C22; C23; C24; C25; C26;

A26-B16- A26-B16- A26-B16- A26-B16- A26-B16- A26-B16C27; C28; C29; C30; C31; C32;

A26-B16- A26-B16- A26-B16- A26-B16- A26-B16- A26-B16C33; C34; C35; C36; C37; C38;

A26-B16- A26-B16- A26-B16- A26-B16- A26-B16- A26-B16C39; C40; C41; C42; C43; C44;

A26-B16- A26-B16- A27-B16-C1; A27-B16-C2; A27-B16-C3; A27-B16-C4;

C45; C46;

A27-B16-C5; A27-B16-C6; A27-B16-C7; A27-B16-C8; A27-B16-C9; A27-B16C10;

A27-B16- A27-B16- A27-B16- A27-B16- A27-B16- A27-B16Cll; C12; C13; C14; C15; C16;

A27-B16- A27-B16- A27-B16- A27-B16- A27-B16- A27-B16C17; C18; C19; C20; C21; C22;

A27-B16- A27-B16- A27-B16- A27-B16- A27-B16- A27-B16C23; C24; C25; C26; C27; C28;

A27-B16- A27-B16- A27-B16- A27-B16- A27-B16- A27-B16C29; C30; C31; C32; C33; C34;

A27-B16- A27-B16- A27-B16- A27-B16- A27-B16- A27-B16C35; C36; C37; C38; C39; C40;

A27-B16- A27-B16- A27-B16- A27-B16- A27-B16- A27-B16C41; C42; C43; C44; C45; C46;

A28-B16-Cl; A28-B16-C2; A28-B16-C3; A28-B16-C4; A28-B16-C5; A28-B16-C6;

A28-B16-C7; A28-B16-C8; A28-B16-C9; A28-B16- A28-B16- A28-B16 C10; Cll; C12;

A28-B16- A28-B16- A28-B16- A28-B16- A28-B16- A28-B16C13; C14; C15; C16; C17; C18;

A28-B16- A28-B16- A28-B16- A28-B16- A28-B16- A28-B16C19; C20; C21; C22; C23; C24;

A28-B16- A28-B16- A28-B16- A28-B16- A28-B16- A28-B16C25; C26; C27; C28; C29; C30;

A28-B16- A28-B16- A28-B16- A28-B16- A28-B16- A28-B16C31; C32; C33; C34; C35; C36;

A28-B16- A28-B16- A28-B16- A28-B16- A28-B16- A28-B16C37; C38; C39; C40; C41; C42;

A28-B16- A28-B16- A28-B16- A28-B16- Al-B17-Cl; A1-B17-C2;

C43; C44; C45; C46;

Al-B17-C3; Al-B17-C4; Al-B17-C5; Al-B17-C6; Al-B17-C7; Al-B17-C8;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -118A1-B17-C9; Al-B17-C10; Al-B17-Cll; Al-B17-C12; Al-B17-C13; Al-B17-C14;

Al-B17-C15; Al-B17-C16; Al-B17-C17; Al-B17-C18; Al-B17-C19; Al-B17-C20;

Al-B17-C21; Al-B17-C22; Al-B17-C23; Al-B17-C24; Al-B17-C25; Al-B17-C26;

Al-B17-C27; Al-B17-C28; Al-B17-C29; Al-B17-C30; Al-B17-C31; Al-B17-C32;

Al-B17-C33; Al-B17-C34; Al-B17-C35; Al-B17-C36; Al-B17-C37; Al-B17-C38;

Al-B17-C39; Al-B17-C40; Al-B17-C41; Al-B17-C42; Al-B17-C43; Al-B17-C44;

Al-B17-C45; Al-B17-C46; A2-B17-Cl; A2-B17-C2; A2-B17-C3; A2-B17-C4;

A2-B17-C5; A2-B17-C6; A2-B17-C7; A2-B17-C8; A2-B17-C9; A2-B17-C10;

A2-B17-C11; A2-B17-C12; A2-B17-C13; A2-B17-C14; A2-B17-C15; A2-B17-C16;

A2-B17-C17; A2-B17-C18; A2-B17-C19; A2-B17-C20; A2-B17-C21; A2-B17-C22;

A2-B17-C23; A2-B17-C24; A2-B17-C25; A2-B17-C26; A2-B17-C27; A2-B17-C28;

A2-B17-C29; A2-B17-C30; A2-B17-C31; A2-B17-C32; A2-B17-C33; A2-B17-C34;

A2-B17-C35; A2-B17-C36; A2-B17-C37; A2-B17-C38; A2-B17-C39; A2-B17-C40;

A2-B17-C41; A2-B17-C42; A2-B17-C43; A2-B17-C44; A2-B17-C45; A2-B17-C46;

A3-B17-Cl; A3-B17-C2; A3-B17-C3; A3-B17-C4; A3-B17-C5; A3-B17-C6;

A3-B17-C7; A3-B17-C8; A3-B17-C9; A3-B17-C10; A3-B17-C11; A3-B17-C12;

A3-B17-C13; A3-B17-C14; A3-B17-C15; A3-B17-C16; A3-B17-C17; A3-B17-C18;

A3-B17-C19; A3-B17-C20; A3-B17-C21; A3-B17-C22; A3-B17-C23; A3-B17-C24;

A3-B17-C25; A3-B17-C26; A3-B17-C27; A3-B17-C28; A3-B17-C29; A3-B17-C30;

A3-B17-C31; A3-B17-C32; A3-B17-C33; A3-B17-C34; A3-B17-C35; A3-B17-C36;

A3-B17-C37; A3-B17-C38; A3-B17-C39; A3-B17-C40; A3-B17-C41; A3-B17-C42;

A3-B17-C43; A3-B17-C44; A3-B17-C45; A3-B17-C46; A4-B17-C1; A4-B17-C2;

A4-B17-C3; A4-B17-C4; A4-B17-C5; A4-B17-C6; A4-B17-C7; A4-B17-C8;

A4-B17-C9; A4-B17-C10; A4-B17-Cll; A4-B17-C12; A4-B17-C13; A4-B17-C14;

A4-B17-C15; A4-B17-C16; A4-B17-C17; A4-B17-C18; A4-B17-C19; A4-B17-C20;

A4-B17-C21; A4-B17-C22; A4-B17-C23; A4-B17-C24; A4-B17-C25; A4-B17-C26;

A4-B17-C27; A4-B17-C28; A4-B17-C29; A4-B17-C30; A4-B17-C31; A4-B17-C32;

A4-B17-C33; A4-B17-C34; A4-B17-C35; A4-B17-C36; A4-B17-C37; A4-B17-C38;

A4-B17-C39; A4-B17-C40; A4-B17-C41; A4-B17-C42; A4-B17-C43; A4-B17-C44;

A4-B17-C45; A4-B17-C46; A5-B17-Cl; A5-B17-C2; A5-B17-C3; A5-B17-C4;

A5-B17-C5; A5-B17-C6; A5-B17-C7; A5-B17-C8; A5-B17-C9; A5-B17-C10;

A5-B17-Cll; A5-B17-C12; A5-B17-C13; A5-B17-C14; A5-B17-C15; A5-B17-C16;

A5-B17-C17; A5-B17-C18; A5-B17-C19; A5-B17-C20; A5-B17-C21; A5-B17-C22;

A5-B17-C23; A5-B17-C24; A5-B17-C25; A5-B17-C26; A5-B17-C27; A5-B17-C28;

A5-B17-C29; A5-B17-C30; A5-B17-C31; A5-B17-C32; A5-B17-C33; A5-B17-C34;

A5-B17-C35; A5-B17-C36; A5-B17-C37; A5-B17-C38; A5-B17-C39; A5-B17-C40;

A5-B17-C41; A5-B17-C42; A5-B17-C43; A5-B17-C44; A5-B17-C45; A5-B17-C46;

A6-B17-Cl; A6-B17-C2; A6-B17-C3; A6-B17-C4; A6-B17-C5; A6-B17-C6;

A6-B17-C7; A6-B17-C8; A6-B17-C9; A6-B17-C10; A6-B17-Cll; A6-B17-C12;

A6-B17-C13; A6-B17-C14; A6-B17-C15; A6-B17-C16; A6-B17-C17; A6-B17-C18;

A6-B17-C19; A6-B17-C20; A6-B17-C21; A6-B17-C22; A6-B17-C23; A6-B17-C24;

A6-B17-C25; A6-B17-C26; A6-B17-C27; A6-B17-C28; A6-B17-C29; A6-B17-C30;

A6-B17-C31; A6-B17-C32; A6-B17-C33; A6-B17-C34; A6-B17-C35; A6-B17-C36;

A6-B17-C37; A6-B17-C38; A6-B17-C39; A6-B17-C40; A6-B17-C41; A6-B17-C42;

A6-B17-C43; A6-B17-C44; A6-B17-C45; A6-B17-C46; A7-B17-C1; A7-B17-C2;

A7-B17-C3; A7-B17-C4; A7-B17-C5; A7-B17-C6; A7-B17-C7; A7-B17-C8;

A7-B17-C9; A7-B17-C10; A7-B17-Cll; A7-B17-C12; A7-B17-C13; A7-B17-C14;

A7-B17-C15; A7-B17-C16; A7-B17-C17; A7-B17-C18; A7-B17-C19; A7-B17-C20;

A7-B17-C21; A7-B17-C22; A7-B17-C23; A7-B17-C24; A7-B17-C25; A7-B17-C26;

A7-B17-C27; A7-B17-C28; A7-B17-C29; A7-B17-C30; A7-B17-C31; A7-B17-C32;

A7-B17-C33; A7-B17-C34; A7-B17-C35; A7-B17-C36; A7-B17-C37; A7-B17-C38;

A7-B17-C39; A7-B17-C40; A7-B17-C41; A7-B17-C42; A7-B17-C43; A7-B17-C44;

A7-B17-C45; A7-B17-C46; A8-B17-Cl; A8-B17-C2; A8-B17-C3; A8-B17-C4;

A8-B17-C5; A8-B17-C6; A8-B17-C7; A8-B17-C8; A8-B17-C9; A8-B17-C10;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -119AS-B17-C11; A8-B17-C12; A8-B17-C13; AS-B17-C14; A8-B17-C15; A8-B17-C16;

A8-B17-C17; AS-B17-C18; A8-B17-C19; A8-B17-C20; A8-B17-C21; A8-B17-C22;

A8-B17-C23; A8-B17-C24; A8-B17-C25; A8-B17-C26; A8-B17-C27; A8-B17-C28;

A8-B17-C29; A8-B17-C30; A8-B17-C31; A8-B17-C32; A8-B17-C33; A8-B17-C34;

A8-B17-C35; A8-B17-C36; A8-B17-C37; A8-B17-C38; A8-B17-C39; A8-B17-C40;

A8-B17-C41; A8-B17-C42; A8-B17-C43; A8-B17-C44; A8-B17-C45; A8-B17-C46;

A9-B17-Cl; A9-B17-C2; A9-B17-C3; A9-B17-C4; A9-B17-C5; A9-B17-C6;

A9-B17-C7; A9-B17-C8; A9-B17-C9; A9-B17-C10; A9-B17-C11; A9-B17-C12;

A9-B17-C13; A9-B17-C14; A9-B17-C15; A9-B17-C16; A9-B17-C17; A9-B17-C18;

A9-B17-C19; A9-B17-C20; A9-B17-C21; A9-B17-C22; A9-B17-C23; A9-B17-C24;

A9-B17-C25; A9-B17-C26; A9-B17-C27; A9-B17-C28; A9-B17-C29; A9-B17-C30;

A9-B17-C31; A9-B17-C32; A9-B17-C33; A9-B17-C34; A9-B17-C35; A9-B17-C36;

A9-B17-C37; A9-B17-C38; A9-B17-C39; A9-B17-C40; A9-B17-C41; A9-B17-C42;

A9-B17-C43; A9-B17-C44; A9-B17-C45; A9-B17-C46; A10-B17-C1; A10-B17-C2;

A10-B17-C3; A10-B17-C4; A10-B17-C5; A10-B17-C6; A10-B17-C7; A10-B17-C8;

A10-B17-C9; A10-B17- A10-B17- A10-B17- A10-B17- A10-B17 C10; Cll; C12; C13; C14;

A10-B17- A10-B17- A10-B17- A10-B17- A10-B17- A10-B17C15; C16; C17; C18; C19; C20;

A10-B17- A10-B17- A10-B17- A10-B17- A10-B17- A10-B17C21; C22; C23; C24; C25; C26;

A10-B17- A10-B17- A10-B17- A10-B17- A10-B17- A10-B17C27; C28; C29; C30; C31; C32;

A10-B17- A10-B17- A10-B17- A10-B17- A10-B17- A10-B17C33; C34; C35; C36; C37; C38;

A10-B17- A10-B17- A10-B17- A10-B17- A10-B17- A10-B17C39; C40; C41; C42; C43; C44;

A10-B17- A10-B17- All-B17-Cl; All-B17-C2; All-B17-C3; All-B17-C4;

C45; C46;

All-B17-C5; All-B17-C6; All-B17-C7; All-B17-C8; All-B17-C9; All-B17C10;

All-B17- A11-B17- All-B17- All-B17- All-B17- All-B17Cli; C12; C13; C14; C15; C16;

All-B17- All-B17- All-B17- All-B17- All-B17- All-B17C17; C18; C19; C20; C21; C22;

All-B17- All-B17- All-B17- All-B17- All-B17- All-B17C23; C24; C25; C26; C27; C28;

All-B17- All-B17- All-B17- All-B17- All-B17- All-B17C29; C30; C31; C32; C33; C34;

All-B17- All-B17- All-B17- All-B17- All-B17- All-B17C35; C36; C37; C38; C39; C40;

A11-B17- All-B17- All-B17- All-B17- All-B17- All-B17C41; C42; C43; C44; C45; C46;

A12-B17-C1; A12-B17-C2; A12-B17-C3; A12-B17-C4; A12-B17-C5; A12-B17-C6;

A12-B17-C7; A12-B17-C8; A12-B17-C9; A12-B17- A12-B17- A12-B17 C10; Cll; C12;

A12-B17- A12-B17- A12-B17- A12-B17- A12-B17- A12-B17C13; C14; C15; C16; C17; CIS;

A12-B17- A12-B17- A12-B17- A12-B17- A12-B17- A12-B17C19; C20; C21; C22; C23; C24;

A12-B17- A12-B17- A12-B17- A12-B17- A12-B17- A12-B17C25; C26; C27; C28; C29; C30;

A12-B17- A12-B17- A12-B17- A12-B17- A12-B17- A12-B17C31; C32; C33; C34; C35; C36;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -120A12-B17- A12-B17- A12-B17- A12-B17- A12-B17- A12-B17C37; C38; C39; C40; C41; C42;

A12-B17- A12-B17- A12-B17- A12-B17- A13-B17-Cl; A13-B17-C2;

C43; C44; C45; C46;

A13-B17-C3; A13-B17-C4; A13-B17-C5; A13-B17-C6; A13-B17-C7; A13-B17-C8;

A13-B17-C9; A13-B17- A13-B17- A13-B17- A13-B17- A13-B17C10; C11; C12; C13; C14;

A13-B17- A13-B17- A13-B17- A13-B17- A13-B17- A13-B17C15; C16; C17; C18; C19; C20;

A13-B17- A13-B17- A13-B17- A13-B17- A13-B17- A13-B17C21; C22; C23; C24; C25; C26;

A13-B17- A13-B17- A13-B17- A13-B17- A13-B17- A13-B17C27; C28; C29; C30; C31; C32;

A13-B17- A13-B17- A13-B17- A13-B17- A13-B17- A13-B17C33; C34; C35; C36; C37; C38;

A13-B17- A13-B17- A13-B17- A13-B17- A13-B17- A13-B17C39; C40; C41; C42; C43; C44;

A13-B17- A13-B17- A14-B17-Cl; A14-B17-C2; A14-B17-C3; A14-B17-C4;

C45; C46;

A14-B17-C5; A14-B17-C6; A14-B17-C7; A14-B17-C8; A14-B17-C9; A14-B17C10;

A14-B17- A14-B17- A14-B17- A14-B17- A14-B17- A14-B17Cil; C12; C13; C14; C15; C16;

A14-B17- A14-B17- A14-B17- A14-B17- A14-B17- A14-B17C17; C18; C19; C20; C21; C22;

A14-B17- A14-B17- A14-B17- A14-B17- A14-B17- A14-B17C23; C24; C25; C26; C27; C28;

A14-B17- A14-B17- A14-B17- A14-B17- A14-B17- A14-B17C29; C30; C31; C32; C33; C34;

A14-B17- A14-B17- A14-B17- A14-B17- A14-B17- A14-B17C35; C36; C37; C38; C39; C40;

A14-B17- A14-B17- A14-B17- A14-B17- A14-B17- A14-B17C41; C42; C43; C44; C45; C46;

A15-B17-Cl; A15-B17-C2; A15-B17-C3; A15-B17-C4; A15-B17-C5; A15-B17-C6;

A15-B17-C7; A15-B17-C8; A15-B17-C9; A15-B17- A15-R17- A15-B17 C10; Cll; C12;

A15-B17- A15-B17- A15-B17- A15-B17- A15-B17- A15-B17C13; C14; C15; C16; C17; C18;

A15-B17- A15-B17- A15-B17- A15-B17- A15-B17- A15-B17C19; C20; C21; C22; C23; C24;

A15-B17- A15-B17- A15-B17- A15-B17- A15-B17- A15-B17C25; C26; C27; C28; C29; C30;

A15-B17- A15-B17- A15-B17- A15-B17- A15-B17- A15-B17C31; C32; C33; C34; C35; C36;

A15-B17- A15-B17- A15-B17- A15-B17- A15-B17- A15-B17C37; C38; C39; C40; C41; C42;

A15-B17- A15-B17- A15-B17- A15-B17- A16-B17-Cl; A16-B17-C2;

C43; C44; C45; C46;

A16-B17-C3; A16-B17-C4; A16-B17-C5; A16-B17-C6; A16-B17-C7; A16-B17-C8;

A16-B17-C9; A16-B17- A16-B17- A16-B17- A16-B17- A16-B17C10; Cll; C12; C13; C14;

A16-B17- A16-B17- A16-B17- A16-B17- A16-B17- A16-B17C15; C16; C17; C18; C19; C20;

A16-B17- A16-B17- A16-B17- A16-B17- A16-B17- A16-B17 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -121C21; C22; C23; C24; C25; C26;

A16-B17- A16-B17- A16-B17- A16-B17- A16-B17- A16-B17C27; C28; C29; C30; C31; C32;

A16-B17- A16-B17- A16-B17- A16-B17- A16-B17- A16-B17C33; C34; C35; C36; C37; C38;

A16-B17- A16-B17- A16-B17- A16-B17- A16-B17- A16-B17C39; C40; C41; C42; C43; C44;

A16-B17- A16-B17- A17-B17-Cl; A17-B17-C2; A17-B17-C3; A17-B17-C4;

C45; C46;

A17-B17-C5; A17-B17-C6; A17-B17-C7; A17-B17-C8; A17-B17-C9; A17-B17C10;

A17-B17- A17-B17- A17-B17- A17-B17- A17-B17- A17-B17Cll; C12; C13; C14; C15; C16;

A17-B17- A17-B17- A17-B17- A17-B17- A17-B17- A17-B17C17; C18; C19; C20; C21; C22;

A17-B17- A17-B17- A17-B17- A17-B17- A17-B17- A17-B17C23; C24; C25; C26; C27; C28;

A17-B17- A17-B17- A17-B17- A17-B17- A17-B17- A17-B17C29; C30; C31; C32; C33; C34;

A17-B17- A17-B17- A17-B17- A17-B17- A17-B17- A17-B17C35; C36; C37; C38; C39; C40;

A17-B17- A17-B17- A17-B17- A17-B17- A17-B17- A17-B17C41; C42; C43; C44; C45; C46;

A18-B17-Cl; A18-B17-C2; A18-B17-C3; A18-B17-C4; A18-B17-C5; A18-B17-C6;

A18-B17-C7; A18-B17-C8; A18-B17-C9; A18-B17- A18-B17- A18-B17 C10; Cli; C12;

A18-B17- A18-B17- A18-B17- A18-B17- A18-B17- A18-B17C13; C14; C15; C16; C17; C18;

A18-B17- A18-B17- A18-B17- A18-B17- A18-B17- A18-B17C19; C20; C21; C22; C23; C24;

A18-B17- A18-B17- A18-B17- A18-B17- A18-B17- A18-B17C25; C26; C27; C28; C29; C30;

A18-B17- A18-B17- A18-B17- A18-B17- A18-B17- A18-B17C31; C32; C33; C34; C35; C36;

A18-B17- A18-B17- A18-B17- A18-B17- A18-B17- A18-B17C37; C38; C39; C40; C41; C42;

A18-B17- A18-B17- A18-B17- A18-B17- A19-B17-Cl; A19-B17-C2;

C43; C44; C45; C46;

A19-B17-C3; A19-B17-C4; A19-B17-C5; A19-B17-C6; A19-B17-C7; A19-B17-C8;

A19-B17-C9; A19-B17- A19-B17- A19-B17- A19-B17- A19-B17C10; C11; C12; C13; C14;

A19-B17- A19-B17- A19-B17- A19-B17- A19-B17- A19-B17C15; C16; C17; C18; C19; C20;

A19-B17- A19-B17- A19-B17- A19-B17- A19-B17- A19-B17C21; C22; C23; C24; C25; C26;

A19-B17- A19-B17- A19-B17- A19-B17- A19-B17- A19-B17C27; C28; C29; C30; C31; C32;

A19-B17- A19-B17- A19-B17- A19-B17- A19-B17- A19-B17C33; C34; C35; C36; C37; C38;

A19-B17- A19-B17- A19-B17- A19-B17- A19-B17- A19-B17C39; C40; C41; C42; C43; C44;

A19-B17- A19-B17- A20-B17-Cl; A20-B17-C2; A20-B17-C3; A20-B17-C4;

C45; C46;

A20-B17-C5; A20-B17-C6; A20-B17-C7; A20-B17-C8; A20-B17-C9; A20-B17 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -122C10;

A20-B17- A20-B17- A20-B17- A20-B17- A20-B17- A20-B17Cll; C12; C13; C14; C15; C16;

A20-B17- A20-B17- A20-B17- A20-B17- A20-B17- A20-B17C17; C18; C19; C20; C21; C22;

A20-B17- A20-B17- A20-B17- A20-B17- A20-B17- A20-B17C23; C24; C25; C26; C27; C28;

A20-B17- A20-B17- A20-B17- A20-B17- A20-B17- A20-B17C29; C30; C31; C32; C33; C34;

A20-B17- A20-B17- A20-B17- A20-B17- A20-B17- A20-1117C35; C36; C37; C38; C39; C40;

A20-B17- A20-B17- A20-B17- A20-B17- A20-B17- A20-B17C41; C42; C43; C44; C45; C46;

A21-B17-Ci; A21-B17-C2; A21-B17-C3; A21-B17-C4; A21-B17-C5; A21-B17-C6;

A21-B17-C7; A21-B17-C8; A21-B17-C9; A21-B17- A21-B17- A21-B17 C10; Cii; C12;

A21-B17- A21-B17- A21-B17- A21-B17- A21-B17- A21-B17C13; C14; C15; C16; C17; CIS;

A21-B17- A21-B17- A21-B17- A21-B17- A21-B17- A21-B17C19; C20; C21; C22; C23; C24;

A21-B17- A21-B17- A21-B17- A21-B17- A21-B17- A21-B17C25; C26; C27; C28; C29; C30;

A21-B17- A21-B17- A21-B17- A21-B17- A21-B17- A21-B17C31; C32; C33; C34; C35; C36;

A21-B17- A21-B17- A21-B17- A21-B17- A21-B17- A21-B17C37; C38; C39; C40; C41; C42;

A21-B17- A21-B17- A21-B17- A21-B17- A22-B17-Cl; A22-B17-C2;

C43; C44; C45; C46;

A22-B17-C3; A22-B17-C4; A22-B17-C5; A22-B17-C6; A22-B17-C7; A22-B17-C8;

A22-B17-C9; A22-B17- A22-B17- A22-B17- A22-B17- A22-B17C10; Cll; C12; C13; C14;

A22-B17- A22-B17- A22-B17- A22-B17- A22-B17- A22-B17C15; C16; C17; C18; C19; C20;

A22-B17- A22-B17- A22-B17- A22-B17- A22-B17- A22-B17C21; C22; C23; C24; C25; C26;

A22-B17- A22-B17- A22-B17- A22-B17- A22-B17- A22-B17C27; C28; C29; C30; C31; C32;

A22-B17- A22-B17- A22-B17- A22-B17- A22-B17- A22-B17C33; C34; C35; C36; C37; C38;

A22-B17- A22-B17- A22-B17- A22-B17- A22-B17- A22-B17C39; C40; C41; C42; C43; C44;

A22-B17- A22-B17- A23-B17-Cl; A23-B17-C2; A23-B17-C3; A23-B17-C4;

C45; C46;

A23-B17-C5; A23-B17-C6; A23-B17-C7; A23-B17-C8; A23-B17-C9; A23-B17C10;

A23-B17- A23-B17- A23-B17- A23-B17- A23-B17- A23-B17Cll; C12; C13; C14; C15; C16;

A23-B17- A23-B17- A23-B17- A23-B17- A23-B17- A23-B17C17; C18; C19; C20; C21; C22;

A23-B17- A23-B17- A23-B17- A23-B17- A23-B17- A23-B17C23; C24; C25; C26; C27; C28;

A23-B17- A23-B17- A23-B17- A23-B17- A23-B17- A23-B17C29; C30; C31; C32; C33; C34;

A23-B17- A23-B17- A23-B17- A23-B17- A23-B17- A23-B17 CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -123C35; C36; C37; C38; C39; C40;

A23-B17- A23-B17- A23-B17- A23-B17- A23-B17- A23-B17C41; C42; C43; C44; C45; C46;

A24-B17-C1; A24-B17-C2; A24-B17-C3; A24-B17-C4; A24-B17-C5; A24-B17-C6;

A24-B17-C7; A24-B17-C8; A24-B17-C9; A24-B17- A24-B17- A24-B17 C10; C11; C12;

A24-B17- A24-B17- A24-B17- A24-B17- A24-B17- A24-B17C13; C14; C15; C16; C17; C18;

A24-B17- A24-B17- A24-B17- A24-B17- A24-B17- A24-B17C19; C20; C21; C22; C23; C24;

A24-B17- A24-B17- A24-B17- A24-B17- A24-B17- A24-B17C25; C26; C27; C28; C29; C30;

A24-B17- A24-B17- A24-B17- A24-B17- A24-B17- A24-B17C31; C32; C33; C34; C35; C36;

A24-B17- A24-B17- A24-B17- A24-B17- A24-B17- A24-B17C37; C38; C39; C40; C41; C42;

A24-B17- A24-B17- A24-B17- A24-B17- A25-B17-Cl; A25-B17-C2;

C43; C44; C45; C46;

A25-B17-C3; A25-B17-C4; A25-B17-C5; A25-B17-C6; A25-B17-C7; A25-B17-C8;

A25-B17-C9; A25-B17- A25-B17- A25-B17- A25-B17- A25-B17C10; Cll; C12; C13; C14;

A25-B17- A25-B17- A25-B17- A25-B17- A25-B17- A25-B17C15; C16; C17; C18; C19; C20;

A25-B17- A25-B17- A25-B17- A25-B17- A25-B17- A25-B17C21; C22; C23; C24; C25; C26;

A25-B17- A25-B17- A25-B17- A25-B17- A25-B17- A25-B17C27; C28; C29; C30; C31; C32;

A25-B17- A25-B17- A25-B17- A25-B17- A25-B17- A25-B17C33; C34; C35; C36; C37; C38;

A25-B17- A25-B17- A25-B17- A25-B17- A25-B17- A25-B17C39; C40; C41; C42; C43; C44;

A25-B17- A25-B17- A26-B17-Cl; A26-B17-C2; A26-B17-C3; A26-B17-C4;

C45; C46;

A26-B17-C5; A26-B17-C6; A26-B17-C7; A26-B17-C8; A26-B17-C9; A26-B17C10;

A26-B17- A26-B17- A26-B17- A26-B17- A26-B17- A26-B17C11; C12; C13; C14; C15; C16;

A26-B17- A26-B17- A26-B17- A26-B17- A26-B17- A26-B17C17; C18; C19; C20; C21; C22;

A26-B17- A26-B17- A26-B17- A26-B17- A26-B17- A26-B17C23; C24; C25; C26; C27; C28;

A26-B17- A26-B17- A26-B17- A26-B17- A26-B17- A26-B17C29; C30; C31; C32; C33; C34;

A26-B17- A26-B17- A26-B17- A26-B17- A26-B17- A26-B17C35; C36; C37; C38; C39; C40;

A26-B17- A26-B17- A26-B17- A26-B17- A26-B17- A26-B17C41; C42; C43; C44; C45; C46;

A27-B17-Cl; A27-B17-C2; A27-B17-C3; A27-B17-C4; A27-B17-C5; A27-B17-C6;

A27-B17-C7; A27-B17-C8; A27-B17-C9; A27-B17- A27-B17- A27-B17 C10; Cll; C12;

A27-B17- A27-B17- A27-B17- A27-B17- A27-B17- A27-B17C13; C14; C15; C16; C17; C18;

A27-B17- A27-B17- A27-B17- A27-B17- A27-B17- A27-B17C19; C20; C21; C22; C23; C24;

CA 02395593 2002-06-25 WO 01/47922 PCT/GBOO/04993 -124A27-B17- A27-B17- A27-B17- A27-B17- A27-B17- A27-B17C25;, C26; C27; C28; C29; C30;

A27-B17- A27-B17- A27-B17- A27-B17- A27-B17- A27-B17C31; C32; C33; C34; C35; C36;

A27-B17- A27-B17- A27-B17- A27-B17- A27-B17- A27-B17C37; C38; C39; C40; C41; C42;