Agent combinations comprising fluopyram and other imicyafos
Abstract
The present invention relates to novel active ingredient combinations which consist of fluopyram and other known active ingredients and are very well suited for the control of animal pests, such as insects and/or unwanted acarids and/or nematodes, in foliar and soil application and/or in the treatment of seeds, and are also suitable for increasing yeilds.

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9 claims: 1 independent, 8 dependent
- 1Patent claims Zastrzeżenia patentowe 1. Active ingredient combinations containing (1-1) N- {2- [3-chloro-5- (trifluoromethyl) -2-pyridinyl] ethyl} -2-trifluoromethylbenzamide according to formula (I) 1. Kombinacje substancji aktywnych zawierające (1-1) N-{2-[3-chloro-5-(trifluorometylo)-2-pirydynylo]etylo}-2-trifluorometylobenzamid według wzoru (I) (fluopiram) jak i jego N-tlenki i (II) owadobójczyą lub ni cieni obój czą substancję aktywną imicyjafos (Π-2). (fluopyram) as well as its N-oxides and (II) the insecticidal or non-shadow active substance imicyafos (Π-2).
801 paragraphs in 1 section, as filed
Description
The invention relates to new combinations of active substances which consist of fluopyram and further known active substances and are very suitable for controlling animal pests such as insects and / or undesirable arachnids and / or nematodes in foliar and soil application and / or in seed treatment and to increase the yield.
[0002] It is already known that certain pyridylethylbenzamides have fungicidal, insecticidal, arachnidic and zwitterionic properties.
WO 2004/016088 discloses pyridylethylbenzamides and their use as fungicides. The same describes the possibility of combining one or more of the disclosed pyridylethylbenzamide derivatives with other known fungicides, insecticides, nematicides and acaricides to broaden the spectrum of action. However, the application teaches neither what insecticidal side of the mixture is appropriate nor the mixing ratio in which the insecticides and pyridylethylbenzamide derivatives are combined with each other. WO 2005/077901 discloses fungicidal compositions comprising at least one pyridylethylbenzamide, one fungicide and one electron transport inhibitor in the fungal respiratory chain. However, the patent application does not mention mixtures of pyridylethylbenzamides with insecticides. WO 2008/003738 discloses fungicidal compositions comprising at least one pyridylethylbenzamide and one insecticide. The application discloses the possible nematocidal effectiveness of the compositions, but not directly for mixtures containing N- {2- [3-chloro-5- (trifhioromethyl) -2-pyridinyl] ethyl} -2-trifluoromethyl with d enzymes.
[0004] The effectiveness of the active substances and active substance compositions described in the prior art is good, but at low application rates in some cases, especially in the control of nematodes, leaves much to be desired.
[0005] It is therefore an object of the present invention to provide oboe shadows, insecticidal and acaricidal active ingredient combinations with improved efficacy, especially against nematodes.
[0006] It has been found that active ingredient combinations containing (1-1) N- {2- [3-chloro-5- (trifluoromethyl) -2-pyridinyl] ethyl} -2-trifluoromethylbenzamide according to formula (I)
<img file="PL3103333T3_D0001.tif" />
(fluopyram) as well as their N-oxides;
-2i (II) at least one active ingredient selected from the group consisting of fluenesulfone (II-1), imicyafos (II-2), Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (Serenade ™) (II -4), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact ™) (II-6), azadirachtin (II-7), thymol (II-8), Metarhizium anisopliae (II-9), Rhizobium spp . (II-10), Beauveria spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752. (II-14), Bacillus subtilis strain GB03 (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Bacillus amyloliquefaciens strain FZB 42 (II-19), Myrothecium verrucaria strain AARC -0255 (II-20), piretrum (II-21), Cydia pomonella granulosis virus (CpGV) (II-22), Metarhizium anisopliae strain F52 (II23), arbuscular mycorrhiza fungus (II-24), Beauveria bassiana strain ATCC 74040 (II-25), Beauveria brongniartii (II-26), Lecanicillium lecanii (also known as Verticillium lecanii) (II-27), Bacillus thuringiensis subspecies tenebrionis (II-28) are very suitable for controlling phytopathogenic fungi and animal pests, especially nematodes, in foliar application or soil, especially in seed treatment and to increase the yield.
[0007] The insecticidal or nematocidal active substances of group (II) are selected from the group consisting of:
fluenesulfones (II-1) known from WO-A 2001/002378 and / or imicyafos (II-2) known from EP-A 0464830 and / or
Bacillus subtilis (II-3) and / or
Bacillus subtilis strain QST 713 (II-4) and / or
Paecilomyces lilacinus (II-5) and / or
Paecilomyces lilacinus strain 251 (II-6) and / or azadirachtin (CAS No 11141-17-6) (II-7) and / or thymol (II-8)
-3 and / or
Metarhizium anisopliae (II-9), and / or
Rhizobium spp. (II-10), and / or
Beauveria spp. (II-11), and / or
Verticillium spp (II-12) and / or
Metschnikowia fructicola (II-13) known from Kurztman and Droby, System. Appl. Microbiol. (2001), 24, pp 395-399 and / or
Metschnikowia fructicola strain NRRL Y-30752, (II-14) known from US-B2 6,994,849 and / or
Bacillus subtilis strain GB03 (II-15) known as Kodiak ™ marketed by Gustafson LLC and / or
Bacillus pumilus strain GB34 known as YieldShield ™ marketed by Gustafson LLC and / or
Bacillus pumilus strain QST2808 known as Sonata ™ marketed by Agraquest and / or
Bacillus amyloliquefaciens strain IN937a and / or
Myrothecium verrucaria strain AARC-0255 known as DiTera ™ marketed by Valent BioSciences and / or pyrethrum (II-21) and / or Cydia pomonella granulosis virus (CpGV) (II-22) and / or
-4Metarhizium anisopliae strain F52 (II-23) and / or arbuscular mycorrhiza (II-24) fungus and / or
Beauveria bassiana strain ATCC 74040 (known as Naturalis®) (II-25) and / or
Beauveria brongniartii (II-26) and / or
Lecanicillium lecanii (formerly known as Verticillium lecanii) (II-27) and / or
Bacillus thuringiensis subspecies tenebrionis (II-28).
[0008] In a preferred embodiment of the disclosure, the active substances of group (II) are selected from the group consisting of fluenesulfone (II-1), imicyafos (II-2), Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 ( Serenade ™) (II-4), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact ™) (II-6), azadirachtin (II-7), thymol (II-8), Metarhizium anisopliae (II- 9), Rhizobium spp. (II-10), Beauveria spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y30752, (II-14).
[0009] In a preferred embodiment of the disclosure, the active substances of group (II) are selected from the group of bacteria consisting of Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (Serenade ™) (II-4), Bacillus subtilis strain GB03) (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Rhizobium spp. (II-10), Bacillus thuringiensis subspecies tenebrionis (II-28).
[0010] In a preferred embodiment of the disclosure, the active substances of group (II) are selected from the group of Bacillus species consisting of Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 (Serenade ™) (II-4), Bacillus subtilis strain GB03) (II-15), Bacillus pumilus strain GB34 (II-16), Bacillus pumilus strain QST2808 (II-17), Bacillus amyloliquefaciens strain IN937a (II-18), Bacillus thuringiensis subspecies tenebrionis (II28).
[0011] In a preferred embodiment of the disclosure, the active substances of group (II) are selected from the group of fungal species consisting of Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact ™) (II-6), Metarhizium anisopliae ( II-9), Beauveria spp. (II-11), Verticillium spp. (II-12), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752. (II-14), Myrothecium verrucaria strain AARC -0255 (II19), Metarhizium anisopliae strain F52 (II-23), arbuscular mycorrhiza fungus (II-24), Beauveria bassiana, especially ATCC 74040 (II-25) strain, Beauveria brongniartii (II-26), Lecanicillium lecanii (formerly known as Verticillium lecanii) (II-27).
[0012] In a preferred embodiment of the disclosure, the active substances of group (II) are selected from the group consisting of fluenesulfone (II-1), imicyafos (II-2), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact ™) (II-6), Metarhizium anisopliae (II-9), Metschnikowia fructicola (II-13), Metschnikowia fructicola strain NRRL Y-30752. (II-14), Bacillus subtilis strain GB03) (II-15), Bacillus amyloliquefaciens strain FZB 42 (II19), Bacillus thuringiensis subspecies tenebrionis (11-28), pyrethrum (II-21), Cydia pomonella granulosis virus (CpGV) (II-22), Metarhizium anisopliae strain F52 (II-23), arbuscular mycorrhiza fungus (II-24).
[0013] In a preferred embodiment of the disclosure, the active substances of group (II) are selected from the group consisting of fluenesulfone (II-1), imicyafos (II-2), Bacillus subtilis (II-3), Bacillus subtilis strain QST 713 ( Serenade ™) (II-4), Paecilomyces lilacinus (II-5), Paecilomyces lilacinus strain 251 (Bioact ™) (II-6) as well as Metschnikowia fructicola (I I-13).
[0014] In a particularly preferred embodiment of the disclosure, the active substances of group (II) are selected from the group consisting of fluenesulfone (II-1), imicyafos (II-2), Bacillus subtilis strain QST 713 (Serenade ™) (II-4 ), Paecilomyces lilacinus strain 251 (Bioact ™) (II-6).
[0015] In a preferred embodiment of the disclosure, the active substances of group (II) are selected from the group consisting of fluenesulfone (II-1), imicyafos (II-2), azadirachtin (II-7), thymol (II-8).
[0016] In a preferred embodiment, the non-therapeutic use of an active ingredient combination as defined above for the control of animal pests is disclosed.
[0017] In a preferred embodiment, the non-therapeutic use of combinations of active substances as defined above for the control of nematodes is disclosed.
[0018] In a preferred embodiment, a non-therapeutic animal pest control is disclosed which is characterized in that combinations of active substances as defined above are allowed to act on the leaves, flowers, stems or seeds of the plants to be protected, the animal pests and / or their environment or soil.
In a preferred embodiment, a method for the production of insecticides and / or acaricides and / or nematicides is disclosed, which is characterized in that the active ingredient combinations as defined above are mixed with diluting agents and / or surface-active compounds.
In a preferred embodiment, compositions containing combinations of active substances as defined above for controlling animal pests are disclosed.
In a preferred embodiment, the use of an active ingredient combination as defined above for the treatment of seeds is disclosed.
In a preferred embodiment, the use of a combination of active substances as defined above for the treatment of soil or artificial substrates is disclosed.
In a preferred embodiment, seed is disclosed containing combinations of active ingredients as defined above.
Surprisingly, the fungicidal, insecticidal and / or acaricidal and / or nematicidal activity, in particular the nematicidal activity of the active compound combinations according to the invention, is significantly higher, especially after application to soil, than the sum of the individual active substances. Thus, there is an unforeseen, truly synergistic effect, and not merely a complement to the action. Furthermore, the active compound combinations according to the invention are suitable for increasing the yield.
Combinations of active substances comprising compounds of formula (I-1) and at least one active substance of formula (II) are preferred.
[0019] The following combinations are of particular interest:
(I-1) + (II-1), (I-1) + (II-2), (I-1) + (II-3), (I-1) + (II-4), (I -1) + (II-5), (I-1) + (II-6), (I1) + (II-7), (I-1) + (II-8), (I-1) + (II-9), (I-1) + (II-10), (I-1) + (II-11), (I-1) + (II-12), (I-1) + (II -13), (I-1) + (II-14), (I-1) + (Π-15), (I-1) + (Π-16), (I-1) + (Π-17 ), (I-1) + (II18), (I-1) + (II-19), (I-1) + (II-20), (I-1) + (II-21), (I -1) + (II-22), (I-1) + (II-23), (I-1) + (II-24), (I-1) + (II-25), (I-1 ) + (II-26), (I-1) + (II-27), (I-1) + (II-28).
The active compound combinations can therefore also contain further fungicidal, acaricide, nematicide or insecticide-effective admixture components.
[0021] If the active substances in the active substance combinations according to the invention are present in certain weight ratios, the improved effect is particularly marked. However, the weight ratios of the active ingredients in active ingredient combinations can be varied within a relatively large range. In general, the combinations according to the invention contain the active substances of formula (I-1) and the mixing side in the mixing ratios given in the table below as advantageous and particularly advantageous.
<td>Blending side</td><td>The preferred mixing ratio: (I-1): mixing side</td><td>Particularly advantageous mixing ratio: (I1): mixing side</td><td>Especially very much favorable ratio mixing: (I-1): mixing side</td>
<td>II-1</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-2</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-3</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-4</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-5</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-6</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-7</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-8</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-9</td><td>500: 1 to 1: 50000</td><td>125: 1 to 1: 12500</td><td>25: 1 to 1: 2500</td>
<td>II-10</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-11</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-12</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-13</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-14</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-15</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-16</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-17</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-18</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-19</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-20</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-21</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-22</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-23</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-24</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-25</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-26</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-27</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
<td>II-28</td><td>500: 1 to 1: 500</td><td>125: 1 to 1: 125</td><td>25: 1 to 1: 25</td>
Animal pests
[0022] The active substance combinations are suitable, with good plant tolerance, for controlling animal pests such as insects and / or arachnids, especially nematodes, which are found in viticulture, horticulture, agriculture, horticulture and forestry. They can advantageously be used as plant protection agents. They are
Effective against sensitive and resistant species and against all or some stages of development. The pests listed above include:
Insects
[0023] From the order of Anoplura (Phthiraptera) e.g. Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., Trichodectes spp.
[0024] From the class of Arachnida e.g. Acarus spp., Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Amphitetranyus viennensis, Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa, Chorioptes spp., Dermanyssus gallinae, Eotetus spp. , Eutetranyus spp., Eriophyes spp., Halotydeus destructor, Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans, Metatetranyus spp., Nuphersa spp., Oligonychus spp., Ornithodoros spp., Phylonychus spp., Phylonychus spp. Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Stenotarsonemus spp., Tarsonemus spp., Tetranyus spp., Vasates lycopersici.
[0025] From the class of Bivalva e.g. Dreissena spp.
[0026] From the order of the Chilopoda, e.g. Geophilus spp., Scutigera spp.
[0027] From the order of the Coleoptera, e.g. Acalymma vittatum, Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Amphimallon solstitialis, Anobium punctatum, Anoplophora spp., Anthonomus spp., Anthrenus spp., Apion spp., Apogonia spp., Atomaria spp., Atomaria spp. , Bruchidius obtectus, Bruchus spp., Cassida spp., Cerotoma trifurcata, Ceutorrhynchus spp., Chaetocnema spp., Cleonus mendicus, Conoderus spp., Cosmopolites spp., Costelytra zealandica, Ctenicera spp., Cryptathi spp. Cylindrocopturus spp., Dermestes spp., Diabrotica spp., Dichocrocis spp., Diloboderus spp., Epilachna spp., Epitrix spp., Faustinus spp., Gibbium psylloides, Hellula undalis, Heteronychus arator, Heterulusylamorpha, Bejsulusylamorpha. , Hypera postica, Hypothenemus spp., Lachnosterna consanguinea, Lema spp., Leptinotarsa decemlineata, Leucoptera spp., Lissorhoptrus oryzophilus, Lixus spp., Luperodes spp., Lyctus spp., Megascelis spp., Melanotus spp., Melanotus spp. Melolontha spp., Migdolus spp., Monochamus spp., Naupactus xanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Oryzaphagus oryzae, Otiorrhynchus spp., Oxycetonia jucunda, Phagaaedon spp., Phagaaedon spp. ., Psylliodes spp., Ptinus spp., Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sphenophorus spp., Sternechus spp., Symphyletes spp., Tanymecus spp., Tenebrio molitor, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus spp.
[0028] From the order of the Collembola, e.g., Onychiurus armatus.
[0029] In the order of the Diplopoda, for example Blaniulus guttulatus.
[0030] From the order of the Diptera, e.g. Aedes spp., Agromyza spp., Anastrepha spp., Anopheles spp., Asphondylia spp., Bactrocera spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata, Chironomusia spp., Chrysomyochia spp., Chrysomyochia spp. spp., Contarinia spp., Cordylobia
-9anthropophaga, Culex spp., Cuterebra spp., Dacus oleae, Dasyneura spp., Delia spp., Dermatobia hominis, Drosophila spp., Echinocnemus spp., Fannia spp., Gastrophilus spp., Hydrellia spp., Hylemyia spposca, Hylemyia spp. spp., Hypoderma spp., Liriomyza spp. Lucilia spp., Musca spp., Nezara spp., Oestrus spp., Oscinella frit, Pegomyia spp., Phorbia spp., Prodiplosis spp., Psila rosae, Rhagoletis spp., Stomoxys spp., Tabanus spp., Tannia spp., Tetanops spp., Tipula spp.
[0031] From the classes of Gastropoda e.g. Arion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp., Pomacea spp., Succinea spp.
[0032] From the class of Helminthen e.g. Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp., Coopericaria spp. , Dracunculus medinensis, Echinococcus granulosus, Echinococcus multilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp, Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium, Trichinella nella britovels, Trichinella natovels, Trichinella natovels, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichuria, Wuchereria bancrofti.
[0033] Furthermore, protozoa such as Eimeria can be controlled.
[0034] In the order of the Heteroptera, e.g. Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Collaria spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Dysdercus spp. Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Monalonion atratum, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata spp. , Pseudacyst persea, Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.
[0035] From the order of the Homopter, e.g. Acyrthosipon spp., Acrogonia spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma piri, Aphisidia spp., Arboridia spp. ., Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp. Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeurodes spp., Dipospisa spp., Diposina spp. ., Dysmicoccus spp., Empoasca spp., Eriosoma spp., Erythroneura spp., Euscelis bilobatus, Ferrisia spp., Geococcus coffeae, Hieroglyphus spp., Homalodisca coagulata, Hyalopterus arundinis, Iderya spp. Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphes
-10spp., Lipaphis erysimi, Macrosiphum spp., Mahanarva spp., Melanaphis sacchari, Metcalfiella spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Orphotettix spp. praelonga, Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planocococcus spp. Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphum spp., Saisseticoidesp. Sogata spp., Sogatella furcifera, Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes spp., Trioza spp., Typhlocyba spp., Unaspis spp., Viteus vitifolii, Zygina spp.
[0036] From the order of the Hymenoptera, e.g. Athalia spp., Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp.
[0037] From the order of the Isopoda, e.g. Armadillidium vulgare, Oniscus asellus, Porcellio scaber.
[0038] From the order of the Isoptera e.g. Acromyrmex spp., Atta spp., Cornitermes cumulans, Microtermes obesi, Odontotermes spp., Reticulitermes spp.
[0039] From the order of the Lepidoptera, e.g. Acronicta major, Adoxophyes spp., Aedia leucomelas, Agrotis spp., Alabama spp., Amyelois transitella, Anarsia spp., Anticarsia spp., Argyroploce spp., Barathra brassicae, Borbo cinnara, Bucculatrix thurberiella, Bupalus pinpiar., Busalus pinpiar. spp., Caloptilia theivora, Capua reticulana, Carpocapsa pomonella, Carposina niponensis, Cheimatobia brumata, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphalocerus spp., Cnephasia spp., Conopomorpha spp., Conopomorpha spp. Copitarsia spp., Cydia spp., Dalaca noctuides, Diaphania spp., Diatraea saccharalis, Earias spp., Ecdytolopha aurantium, Elasmopalpus lignosellus, Eldana saccharina, Ephestia kuehniella, Epinotia spp., Eiphyaslavitt. ambiguella, Euproctis spp., Euxoa spp., Feltia spp., Galleria mellonella, Gracillaria spp., Grapholitha spp., Hedylepta spp., Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella, Homoeosoma spp., Homona spp. Hyponomeuta padella, Kakivoria flavofasciata, Laphygma spp., Laspeyresia molesta, Leucinodes orbonalis, Leucoptera spp., Lithocolletis spp., Lithophane antennata, Lobesia spp., Loxagrotis albicosta, Lymantria spp., Lymantria spp., Malacetia spp., Lyon Malacestoma spp. , Mocis spp., Mythimna separata, Nymphula spp., Oiketicus spp., Oria spp., Orthaga spp., Ostrinia spp., Oulema oryzae, Panolis flammea, Parnara spp., Pectinophora spp., Perileucoptera spp., Phthorimaea spp., Phyllocnistis citrella, Phyllonorycter spp., Pieris spp., Platynota stultana, Plusia spp., Plutella xylostella, Prays spp., Prodenia spp., Protoparce spp., Pseudaletia spp., Pseudoplusia includens, Pyrausta nubilalis, Schiplusia spp. Scirpophaga spp., Scotia segetum, Sesamia spp., Sparganothis spp., Spodoptera spp., Stathmopoda spp., Stomopteryx subsecivella, Synanthedon spp., Tecia solanivora, Thermesia gemmatrix, Tinea pellionella, Tineola sppiella, bisspell. Trichoplusia spp., Tuta absoluta, Virachola spp.
[0040] From the order of the Orthoptera, e.g., Acheta domesticus, Blatta orientalis, Blattella germanica, Dichroplus spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Melanoplus spp., Periplaneta americana, Schistocerca gregaria.
[0041] From the order of the Siphonaptera, e.g. Ceratophyllus spp., Xenopsylla cheopis.
[0042] From the order of the Symphyla, e.g. Scutigerella spp ..
[0043] From the order of the Thysanoptera, e.g., Anaphothrips obscurus, Baliothrips biformis, Drepanothris reuteri, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Rhipiphorothrips cruentatus, Scirtothrothrips spp.
[0044] From the order of the Thysanura, e.g. Lepisma saccharina.
Nematodes
[0045] In principle, it is possible to combat all kinds of plant parasitic nematodes with the active substance combinations according to the invention. The active substance combinations according to the invention have proved to be particularly advantageous for controlling nematodes, which are selected from the group consisting of: Aglenchus agricola, Anguina tritici, Aphelenchoides arachidis, Aphelenchoides fragariae, Belonolaimus gracilis, Belonolaimus longicaudatus, Belonolaimus nortoni, Cacopaurus pestis, Cacopaurus curvata. onensis, Criconemella ornata, Criconemella rusium, Criconemella xenoplax (= Mesocriconema xenoplax) and Criconemella spp. in general, Criconemoides ferniae, Criconemoides onense, Criconemoides ornatum and Criconemoides spp. in general, Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and Ditylenchus spp. in general, Dolichodorus heterocephalus, Globodera pallida (= Heterodera pallida), Globodera rostochiensis, Globodera solanacearum, Globodera tabacum, Globodera virginiae, Helicotylenchus digonicus, Helicotylenchus dihystera, Helicotylenchus erythrinus, Helicotylenchus erythrine, Helicotylenchus nerythrine, Helicotylenchus erythrinus, Helicotylenchus erythrine, Helicotylenchus. generally, Hemicriconemoides, Hemicycliophora arenaria, Hemicycliophora nudata, Hemicycliophora parvana, Heterodera avenae, Heterodera cruciferae, Heterodera glycines, Heterodera oryzae, Heterodera schachtii, Heterodera zeae and Heterodera spp. in general, Hoplolaimus aegyptii, Hoplolaimus californicus, Hoplolaimus columbus, Hoplolaimus galeatus, Hoplolaimus indicus, Hoplolaimus magnistylus, Hoplolaimus pararobustus, Longidorus africanus, Longidorus breviannulatus, Longidorus elongatola, Longidorus vineporus elongatus, Longidorus vineporus elongatus, Longorus vineporus. generally, Meloidogyne acronea, Meloidogyne africana, Meloidogyne arenaria, Meloidogyne arenaria thamesi, Meloidogyne artiella, Meloidogyne chitwoodi, Meloidogyne coffeicola, Meloidogyne Ethiopic, Meloidogyne exigua, Meloidogyne graminicola, Meloidogyne graminis, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne incognita acrita, Meloidogyne javanica, Meloidogyne kikuyensis, Meloidogyne naasi, Meloidogyne paranaensis, Meloidogyne thamesi and Meloidogyne spp. in general, Meloinema spp., Nacobbus aberrans, Neotylenchus vigissi, Paraphelenchus pseudoparietinus, Paratrichodorus allius, Paratrichodorus lobatus, Paratrichodorus minor, Paratrichodorus nanus, Paratrichodorus porosus, Paratrichod hamsat teres, Paratrylenchatusatylenus, Paratrylenchatus minutus and Paratrylenchylenus minutus. generally, Pratylenchus
-12agilis, Pratylenchus Allen, Pratylenchus andinus, Pratylenchus brachyurus, Pratylenchus cerealis, Pratylenchus coffeae, Pratylenchus crenatus, Pratylenchus delattrei, Pratylenchus giibbicaudatus, Pratylenchus goodeyi, Pratylenchus hamatus, Pratylenchus hexincisus, Pratylenchus loosi, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus pratensis, Pratylenchus scribneri , Pratylenchus teres, Pratylenchus thornei, Pratylenchus vulnus, Pratylenchus zeae and Pratylenchus spp. in general, Pseudohalenchus minutus, Psilenchus magnidens, Psilenchus tumidus, Punctodera chalcoensis, Quinisulcius acutus, Radopholus citrophilus, Radopholus similis, Rotylenchulus borealis, Rotylenchulus parvus, Rotylenchulus rotylenus in general, Rotylenus Roturentus, Rotylenus Rotylench Rotylenus Rotylenus Rotylenchulus reniulformis and Rotylenchulus Rotylenchulus reniulformisp. spp. in general, Scutellonema brachyurum, Scutellonema bradys, Scutellonema clathricaudatum and Scutellonema spp. generally, Subanguina radiciola, Tetylenchus nicotianae, Trichodorus cylindricus, Trichodorus minor, Trichodorus primitivus, Trichodorus proximus, Trichodorus similis, Trichodorus sparsus and Trichodorus spp. generally, Tylenchorhynchus agri, Tylenchorhynchus brassicae, Tylenchorhynchus Clarus, Tylenchorhynchus claytoni, Tylenchorhynchus digitatus, Tylenchorhynchus ebriensis, Tylenchorhynchus maximus, Tylenchorhynchus nudus, Tylenchorhynchus vulgaris and Tylenchorhynchus spp. in general, Tylenchulus semipenetrans, Xiphinema americanum, Xiphinema brevicolle, Xiphinema dimorphicaudatum, Xiphinema index and Xiphinema spp. in general.
[0046] The active substance combinations according to the invention for controlling nematodes have proved to be particularly advantageous, which are selected from the group consisting of: Meloidogyne spp. Such as, for example, Meloidogyne incognita, Meloidogyne javanica, Meloidogyne hapla, Meloidogyne arenaria; Ditylenchus ssp., Such as, for example, Ditylenchus dipsaci, Ditylelenchus destructor; Pratylenchus ssp., Such as Pratylenchus penetrans, Pratylenchus fallax, Pratylenchus coffeae, Pratylenchus loosi, Pratylenchus vulnus; Globodera spp. Such as, for example, Globodera rostochiensis, Globodera pallida etc .; Heterodera spp. Such as Heterodera glycines Heterodera shachtoii etc .; Aphelenchoides spp., Such as, for example, Aphelenchoides besseyi, Aphelenchoides ritzemabosi, Aphelenchoides fragarieae; Aphelenchus ssp., Such as, for example, Aphelenchus avenae; Radopholus ssp, such as, for example, Radopholus similis; Tylenchulus ssp., Such as Tylenchulus semipenetrans; Rotylenchulus ssp., Such as, for example, Rotylenchulus reniformis;
Bursaphelenchus spp., Such as, for example, Bursaphelenchus xylophilus, Aphelenchoides spp., Longidorus spp., Xiphinema spp., Trichodorus spp.
[0047] Furthermore, the active ingredient combinations according to the invention have proven effective against nematodes that attack humans or animals, such as e.g. roundworm, pinworm, pillars, Wuchereri bancrofti, nematodes (convoluted filaria), Gnathostoma, etc.
Animal health
The active substance combinations according to the invention are active not only against plant, hygiene and storage pests, but also in the veterinary sector, against animal parasites (ecto- and endoparasites) such as hard ticks, ticks
-13 riparian mites, scabies mites, land mites, flies (stinging and licking), parasitic fly larvae, lice, lice, feathers and fleas. These parasites include:
From the order of the Anoplurida, e.g. Haematopinus spp., Linognathus spp., Pediculus spp., Phtirus spp., Solenopotes spp.
[0049] From the order of Mallophagida and the suborder Amblycerina as well as Ischnocerina, e.g. Trimenopon spp., Menopon spp., Trinoton spp., Bovicola spp., Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp., Felicola spp.
[0050] From the order of Diptera and the suborder Nematocerina and Brachycerina, e.g. Aedes spp., Anopheles spp., Culex spp., Simulium spp., Eusimulium spp., Phlebotomus spp., Lutzomyia spp., Culicoides spp., Chrysops spp., Hybomitra spp., Atylotus spp., Tabanus spp., Haematopota spp. ., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., Hippobosca spp., Lipoptena spp., Melophagus spp ..
[0051] From the order of the Siphonapterida, e.g. Pulex spp., Ctenocephalides spp., Xenopsylla spp., Ceratophyllus spp.
[0052] From the order of the Heteropterida e.g. Cimex spp., Triatoma spp., Rhodnius spp., Panstrongylus spp.
[0053] From the order of the Blattarida, e.g. Blatta orientalis, Periplaneta americana, Blattela germanica, Supella spp.
[0054] From the Acari (Acarina) subclass and the Meta and Mesostigmata orders e.g. Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Boophilus spp., Dermacentor spp. Hyalomma spp., Rhipicephalus spp., Dermanyssus spp., Raillietia spp., Pneumonyssus spp., Sternostoma spp., Varroa spp.
[0055] From the order of the Actinedida (Prostigmata) and Acaridida (Astigmata) e.g. Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombicula spp., Listrophorus spp., Acus spp. ., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites .. spp.
The active compound combinations according to the invention are also suitable for the control of arthropods that infest farm animals, such as, for example, cattle, sheep, goats, horses, pigs, donkeys, camels, buffaloes, rabbits, chickens, turkeys, ducks, geese, bees. , other domestic animals for example dogs, cats, caged birds, aquarium fish as well as so-called test animals, for example hamsters, guinea pigs, rats and mice. By combating these arthropods, deaths and reductions in yields (meat, milk, wool, hides, eggs, honey, etc.) should be reduced, so that by using the active ingredient combinations according to the invention, more economical and easier rearing of animals is possible.
The use of the active substance combinations according to the invention takes place in the veterinary sector and animal husbandry by a known route by enteral administration in the form of, for example, tablets, capsules, drinkers, sprinkles, granules, pastes, boluses, feed-through methods, suppositories, by administration parenteral, such as by injections (intramuscular, subcutaneous, intravenous, intraperitoneal and others), implants, by intranasal application, by dermal application in the form of, for example, dipping or bathing (immersion), spraying (spray), pouring (pour-on and spot-on), washing, powdering, and with the use of shaped articles containing an active substance, such as collars, earrings, tail tags, limb bracelets, bridles, branding devices etc.
When used in cattle, poultry, domestic animals etc., combinations of active substances can be used as formulations (e.g. powders, emulsions, flowable agents) which contain the active substances in an amount of 1 to 80% by weight, directly or 100 to 10% by weight. 000 times dilution or use it as a chemical bath.
Crops
[0059] Only the crops to be protected generally described are differentiated and defined in more detail below. Thus, when used with vegetables, it is meant, for example, fruit vegetables and inflorescences as vegetables, for example carrots, peppers, pepperoni peppers, tomatoes, eggplants, cucumbers, pumpkins, courgettes, broad beans, beans, string beans, peas, artichokes, corn;
but also leafy vegetables, for example lettuce, chicory, endive, watercress, centipede, lamb's lettuce, iceberg lettuce, leek, spinach, chard;
in addition, tuber vegetables, root vegetables and stem vegetables, for example celery, red beets, carrots, radishes, horseradish, snakeskin, asparagus, turnips, palm shoots, bamboo shoots, furthermore onion vegetables, for example onions, leeks, dill, garlic;
in addition, cruciferous vegetables such as cauliflower, broccoli, kohlrabi, red cabbage, white cabbage, green cabbage, kale, Brussels sprouts, Chinese cabbage.
[0060] With regard to perennial uses, citrus is meant, such as, for example, oranges, grapefruits, mandarins, lemons, limes, bitter oranges, kumquats, satsumas;
but also pome fruits, such as, for example, apples, pears and quinces, and stone fruits, such as, for example, peaches, nectarines, cherries, plums, plums, apricots;
in addition, grapevines, hops, olives, tea, soybeans, rapeseed, cotton, sugar cane, beetroot, potatoes, tobacco and tropical crops such as, for example, mangoes, papayas, figs, pineapples, dates, bananas, durians, coconuts, coconuts , cocoa, coffee, avocado, lychee, passion fruit, guavas, also almonds and nuts, such as hazelnuts, walnuts, pistachios, cashews, Brazil nuts, pecans, gray nuts, chestnuts, hickory nuts, macadamia nuts, peanuts,
Moreover, also berries such as, for example, currants, gooseberries, raspberries, blackberries, blueberries, strawberries, lingonberries, kiwi, cranberries.
For use, ornamental plants are understood to mean annual and perennial plants, e.g. cut flowers such as, for example, roses, carnations, gerberas, lilies, daisies, chrysanthemums, tulips, narcissi, anemones, poppies, amaryllis, dahlias, azaleas, mallow, but also e.g. cuttings, potted plants and shrubs, such as, for example, roses, marigolds, pansies, geraniums, fuchsia, hibiscus, chrysanthemums, impatiens, alpine violets, African violets, sunflowers, begonias, ornamental lawns and golf turfs, but also cereals such as barley, wheat, rye, triticale, oats, rice, millet, corn, in addition, for example, shrubs and conifers, such as, for example, ficus, rhododendron, spruce, fir, pine, yew, juniper, pine, oleander.
[0062] With regard to the use of spices, annual and perennial plants are meant, such as, for example, anise, chili, paprika, pepper, vanilla, marjoram, thyme, cloves, juniper berries, cinnamon, tarragon, coriander, saffron, ginger.
[0063] The crops to be protected are especially those highlighted below: peppers, pepperoni peppers, tomatoes, eggplants, cucumbers, pumpkins, courgettes, artichokes, corn, celery, red beets, carrots, radishes, horseradish, snakes, asparagus, turnips, palm shoots, bamboo shoots, onion, leek, oranges, grapefruits, mandarins, lemons, limes, bitter oranges, kumquats, satsumas, apples, pears and quinces and stone fruits, such as, for example, peaches, nectarines, cherries, plums, Hungarian plums, apricots, grapevines, hops, soybeans, rapeseed, cotton, sugarcane , beets, potatoes, tobacco, hazelnuts, walnuts, pistachios, cashews, Brazil nuts, pecans, gray nuts, chestnuts, hickory nuts, macadamia nuts, peanuts, roses, cloves, gerberas, lilies, daisies, chrysanthemums, tulips , daffodils, anemones, poppy, amaryllis, dahlias, azaleas, mallow, barley, wheat, rye, triticale, oats, rice, millet, corn.
[0064] According to the invention, it is possible to treat all plants and parts of plants. Plants are understood to mean all plants and plant populations, such as desired and undesirable species of wild plants or crops (including naturally occurring crops). Crop plants can be plants that can be obtained by conventional cultivation and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including transgenic plants and including protected and unprotected plant varieties protected by plant species protection.
GMO
[0065] In another preferred embodiment, transgenic plants and plant cultivars which have been obtained by genetic engineering methods, possibly in combination with conventional methods (Genetically Modified Organisms), and parts thereof are treated. The term "parts" or "parts of plants" or "plant parts" has been explained above.
The plants of the plant varieties which are commercially accepted or in use are particularly preferably treated according to the invention.
[0067] Depending on the type of plants or plant cultivars, their location and growth conditions (substrate, climate, growing season, nutrition), also superadditive ("synergistic") effects can occur through the treatment according to the invention. Thus, for example, reduced application rates and / or a broadening of the action spectrum and / or an enhancement of the action of the raw materials and agents used according to the invention, improved plant growth, improved tolerance to high or low temperatures, increased drought tolerance or increased salt content in water and soil, are possible, better flowering, easier harvesting, faster maturation, higher harvest yields, higher quality and / or higher nutritional value of the harvested crops, higher storage stability and / or improved processing characteristics of the harvested crop, which actually exceed the expected results.
[0068] According to the invention, it is possible to treat all plants and parts of plants. Plants are understood here to mean all plants and plant populations, such as desired and undesirable wild plants, plant species and varieties and crops (whether or not they can be protected by plant species protection or plant breeding rights). Plant species and varieties can be plants that have been obtained by traditional methods of reproduction and breeding that can be promoted by one or more biotechnological methods, for example, the use of double haploids, protoplast fusion, random and guided mutagenesis, molecular or genetic markers, or by bioengineering and bioengineering methods and methods of genetic engineering. Parts of plants are understood to mean all above-ground and underground parts and organs of plants, such as shoot, leaf, flower and root, including, for example, leaves, needles, stems, trunks, flowers, fruiting bodies, fruits and seeds as well as roots, tubers and rhizomes. . Plant parts also include crops as well as vegetative and generative seed, for example cuttings, tubers, rhizomes, runners and seeds.
[0069] Among the plants that can be protected by the method of the invention, mention may be made of: major field crops such as corn, soybean, cotton, brassica oilseeds such as Brassica napus (e.g. Canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica carinata, rice, wheat, sugar beet, sugarcane, oats, rye, barley, millet, triticale, flax, grapevine and various fruits and vegetables from various botanical taxa such as Rosaceae sp. (e.g. pome fruits like apples and pears, but also stone fruits like apricots, cherries, almonds and peaches and berries like strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp. , Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (For example banana trees and banana plantations), Rubiaceae sp. (For example coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. ( e.g. lemons, oranges and grapefruit); Solanaceae sp. (for example tomatoes, potatoes, pepper, eggplant), Liliaceae sp., Compositiae sp. (for example lettuce, artichoke and chicory among them chicory roots, endive or chicory), Umbelliferae sp. (for example carrots, parsley, celery and root), Cucurbitaceae sp. (e.g. cucumber, but not limited to pickling cucumbers, pumpkin, watermelon, squashes and melons), Alliaceae sp. (for
-17example onion and garlic), Cruciferae sp. (For example white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, Pak Choi cabbage, kohlrabi, radish / radish, horseradish, watercress, Chinese cabbage), Leguminosae sp. (For example peanuts peanuts and beans - like tic beans and broad beans), Chenopodiaceae sp. (e.g. Swiss chard, white cabbage, spinach, red beet), Malvaceae (e.g. Chinese rose), Asparagaceae (e.g. asparagus); garden and forest crops; ornamental plants; as well as genetically modified homologues of these crops.
[0070] The method of treatment according to the invention can be used to treat genetically modified organisms (GMOs), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants in which a heterologous gene has been stably integrated into the genome. The term "heterologous gene" essentially means a gene that has been made or assembled outside the plant and which, when introduced into the genome of the cell nucleus, the chloroplast genome or the genome of the mitochondria, thereby provides the transformed plant with new or improved agronomic or other properties such that it expresses a protein or polypeptide of interest, or that it lowers or turns off another gene or genes, which are in the plant (for example by antisense technology, co-suppression technology or RNAi technology (RNAi-Technologies)). A heterologous gene that is in the genome is also called a transgene. A transgene that is determined by its specific location in the genome of a plant is called a transformation event or a transgenic event.
[0071] Depending on the type of plants or plant varieties, their location and growing conditions (substrate, climate, growing season, nutrition), treatment according to the invention can also lead to superadditive ("synergistic") effects. Thus, for example, the following effects are possible that actually go beyond the expected effects: reduced application rates and / or a broadened spectrum of action and / or increased effectiveness of the active substances and compositions that can be used according to the invention, improved plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or the water or salt content of the soil, better flowering, easier harvesting, faster ripening, higher harvest yields, larger fruit, higher plant height, more intense green color of the leaf, earlier flowering, higher quality and / or higher nutritional value of the harvested crop, higher sugar concentration in the fruit, better storage stability and / or improved processing characteristics of the harvested crop.
[0072] In certain amounts of use, the active substance combinations according to the invention may also exert a tonic effect on plants. They are therefore suitable for mobilizing plant immune systems against attack by undesirable microorganisms. This may possibly be one of the reasons for the increased effectiveness of the combinations according to the invention, for example against fungi. Plant enhancers (immunity inducers) should in this context also mean substances or combinations of substances which are capable of stimulating the plant immune system in such a way,
That the treated plants, if inoculated thereafter with undesirable microorganisms, have a significant degree of resistance to these microorganisms. In this case, undesirable microorganisms are understood to mean phytopathogenic fungi, bacteria and viruses. The substances according to the invention can therefore be used to protect plants against invasion by undesirable pathogens within a certain period of time after treatment. The period of time during which the protective effect is achieved is usually from 1 to 10 days, preferably 1 to 7 days, after the plants are treated with the active substances.
[0073] Plants and plant cultivars which are preferably treated according to the invention include all plants which have genetic material which gives these plants particularly advantageous useful traits (whether this has been achieved by breeding and / or biotechnology).
Plants and plant varieties which are likewise preferably treated according to the invention are resistant to one or more biotic stress factors, i.e. these plants have an improved defense against animal and microbial pests such as nematodes, insects, mites, phytopathogenic fungi, bacteria. , viruses and / or viroids.
Examples of nematode resistant plants are for example those disclosed in US Patent Applications 11 / 765,491, 11 / 765,494, 10 / 926,819, 10 / 782,020, 12 / 032,479, 10 / 783,417, 10 / 782,096, 11 / 657,964, 12 / 192.904, 11 / 396.808, 12 / 166.253, 12 / 166.239, 12 / 166.124, 12 / 166.209, 11 / 762.886, 12 / 364.335, 11 / 763.947, 12 / 252.453, 12 / 209.354, 12 / 491.396 or 12 / 497.221.
Plants and plant cultivars which may also advantageously be treated according to the invention are those plants which are resistant to one or more abiotic stress factors. Abiotic stress conditions may include, for example, drought, cold and heat conditions, osmotic stress, flooding, increased salt content in the substrate, increased exposure to minerals, ozone conditions, high light conditions, limited availability of nitrogenous nutrients, limited availability of phosphorus nutrients, or shadow avoidance.
[0077] Plants and plant varieties which can also be treated in the same way according to the invention are those plants which are characterized by improved yield properties. The increased yield in these plants may consist, for example, in on improved plant physiology, improved plant growth, and improved plant development, such as water efficiency, water holding efficiency, improved nitrogen utilization, increased carbon fixation, improved photosynthesis, enhanced germination power and accelerated maturation. Yield can be influenced through improved plant architecture (under stress and non-stress conditions) including early flowering, flowering control to produce hybrid seeds, plant germination strength, plant size, number and spacing of internodes, root growth, seed size, size fruit, size of pods, number of pods or ears, number of seeds per pod or ear, weight of seeds, enhanced seed filling, reduced seed dispersal, reduced pod leakage and durability. Other features of the yield are the composition of the seeds, such as carbohydrate content, content
-19proteins, oil content and oil composition, nutritional value, reduction of anti-nutritional compounds, improved processing and improved storage capacity.
[0078] Examples of plants with the above-mentioned characteristics are listed in Table A, which, however, is not exhaustive.
Plants that may be treated according to the invention are hybrid plants that already express heterosis properties or hybrid effects, leading substantially to higher yield, higher growth force, better health and better resistance to biotic and abiotic stress factors. Such plants are typically produced by crossing an inbred male sterile parent line (female cross side) with another inbred male fertile parent line (male cross side). Hybrid seed is typically harvested from male sterile plants and sold to propagators. Male sterile plants can sometimes be produced (e.g. in maize) by detaseling, i.e. mechanical separation of male sexual organs (or male flowers); however, it is more conventional that male sterility relies on genetic determinants in the plant genome. In this case, especially when the desired product which is harvested from the hybrid plants is seed, it is usually advantageous to ensure that male fertility is completely rebuilt in the hybrid plants. This can be achieved by the fact that the male side of crossbreeding has appropriate fertility restorer genes that are able to rebuild male fertility in hybrid plants that contain the genetic determinants that are responsible for male sterility. Genetic determinants of pollen sterility may be located in the cytoplasm. Examples of cytoplasmic pollen sterility (CMS) have been described for example for Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and US 6,229,072). Genetic determinants of pollen sterility can, however, also be localized in the genome of the nucleus. Plants with sterile pollen can also be obtained by plant biotechnology methods such as gene technology. A particularly advantageous agent for the production of male sterile plants is disclosed in WO 89/10396 where, for example, a ribonuclease such as barnase is selectively expressed in tapetum cells in the stamens. Fertility can then be restored by expressing a ribonuclease inhibitor like Barstar in tapetum cells (e.g. WO 91/02069).
Plants or plant cultivars (which are obtained by plant biotechnology methods, such as gene technology) which can advantageously be treated according to the invention are herbicide tolerant plants, i.e. plants which have been made tolerant to one or more of the previously indicated herbicides. Such plants may be obtained by genetic transformation or by selection of plants which contain a mutation which confers such herbicide tolerance.
[0081] Herbicide-tolerant plants are, for example, glyphosate-tolerant plants, i.e. plants that have been made tolerant to the herbicide glyphosate or its salts. Plants can be made tolerant to glyphosate in a number of ways. Thus, glyphosate tolerant plants can, for example, be obtained by plant transformation
-20-gene that encodes the enzyme 5-enolpyruvylshikim-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of Salmonella typhimurium (Comai et al., Science (1983), 221, 370-371), the CP4 gene of Agrobacterium sp. (Barry et al., Curr. Topics Plant Physiol. (1992), 7, 139-145), genes that encode petunia EPSPS (Shah et al., Science (1986), 233, 478-481), tomato EPSPS (Gasser et al., J. Biol. Chem. . (1988), 263, 4280-4289) or Eleusine EPSPS (WO 01/66704). It may also be a mutant EPSPS as disclosed, for example, in EP 0837944, WO 00/66746, WO 00/66747 or WO 02/26995. Glyphosate tolerant plants can also be obtained by expressing a gene that encodes the enzyme glyphosate oxidoreductase as disclosed in US Patents 5,776,760 and 5,463,175 Glyphosate tolerant plants can also be obtained by expressing a gene that encodes the enzyme glyphosate acetyltransferase as disclosed is e.g. WO 02/036782, WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants can also be obtained by selecting plants that contain a naturally occurring mutation of the above-mentioned genes, as disclosed in, for example, WO 01/024615 or WO 03/013226. Plants that express EPSPS genes conferring glyphosate tolerance are, for example, disclosed in Patent Application Nos. 11 / 517,991, 10 / 739,610, 12 / 139,408, 12 / 352,532, 11 / 312,866, 11 / 315,678, 12 / 421,292, 11 / 400,598. , 11 / 651,752, 11 / 681,285, 11 / 605,824, 12 / 468,205, 11 / 760,570, 11 / 762,526, 11 / 769,327, 11 / 769,255, 11/943801, or 12 / 362.774. Plants that contain other glyphosate tolerance genes, such as decarboxylase genes, are for example disclosed in US Patent Application 11 / 588,811, 11 / 185,342, 12 / 364,724, 11 / 185,560 or 12 / 423,926.
[0082] Other herbicide-tolerant plants are, for example, plants that have been made tolerant to herbicides that inhibit the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme that detoxifies a herbicide or mutant glutamine synthase enzyme that is resistant to inhibition, for example as described in US patent application 11 / 760,602. Such an effective detoxifying enzyme is, for example, an enzyme that encodes a phosphinotricin acetyltransferase (such as, for example, the bar or pat protein of the Streptomyces genera). Plants that express exogenous phosphinothricin acetyltransferase are disclosed, for example, in US patents. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.
[0083] Another herbicide-tolerant plant is also plants that have been made tolerant to herbicides that inhibit the enzyme hydroxyphenylpyruvate dioxygenase (HPPD). HPPDs are enzymes which catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is reacted into a homogenate. Plants that are tolerant to HPPD inhibitors can be transformed with a gene that encodes a naturally occurring resistant HPPD enzyme or a gene that encodes a mutant or chimeric HPPD enzyme according to WO 96/38567, WO 99/24585 and WO 99/24586. Tolerance towards HPPD inhibitors can also be achieved by transforming plants with genes that code for certain enzymes that allow homogenate formation despite inhibition of the native HPPD enzyme by HPPD inhibitors. Such
Plants and genes are disclosed in WO 99/34008 and WO 02/36787. The tolerance of plants to HPPD inhibitors can be improved by transforming in addition to one gene that codes for an HPPD tolerant enzyme with a gene that codes for an enzyme with pre-phenate dehydrogenase activity (PDH activity), as disclosed in WO 2004/024928. In addition, plants can be made more tolerant to HPPD-inhibiting herbicides by adding a gene to their genome that codes for an enzyme that has the ability to metabolize or degrade HPPD inhibitors, as shown in WO 2007/103567 and WO 2008/150473 enzymes CYP450.
[0084] Yet another herbicide-resistant plants are plants that have been made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidine, pyrimidinyloxy (thio) benzoate and / or sulfonylaminocarbonyltriazolinone herbicides. Various mutations in the ALS enzyme (also known as acetohydroxy acid synthase, AHAS) are known to impart tolerance to various herbicides or groups of herbicides, as disclosed, for example, in Tranel and Wright, Weed Science (2002), 50, 700-712, however also in US patents 5,605,011, 5,378,824, 5,141,870, and 5,013,659. The production of sulfonylurea tolerant plants and imidazolinone tolerant plants is disclosed in US Patents 5,605,011; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824; as well as in the international publication WO 96/33270. Further imidazolinone tolerant plants are also disclosed in e.g. WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351 and WO 2006/060634. . Further sulfonylurea and imidazolinone tolerant plants are also disclosed e.g. in WO 07/024782 and in US Patent Application 61/288958.
[0085] Further plants that are imidazolinone and / or sulfonylurea tolerant can also be obtained by induced mutagenesis, selection in cell cultures in the presence of a herbicide, or by mutation breeding, as for example disclosed for soybeans in US Patent 5,084,082, to to rice WO 97/41218, for sugar beet in US Patent 5,773,702 and WO 99/057965, for lettuce in US Patent 5,198,599 or for sunflower in WO 01/065922.
Plants or plant cultivars (which are obtained by plant biotechnology methods such as gene technology) which may be treated in the same way according to the invention are transgenic insect resistant plants, i.e. plants which have been made resistant to the invasion of certain target insects. Such plants may be obtained by genetic transformation or by selection of plants which contain a mutation which confers such resistance to insects.
[0087] The term "transgenic insect resistant plants" in this context includes any plant that contains at least one transgene that includes a coding sequence that codes for the following:
1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as insecticidal crystal proteins, was compiled by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, updated by Crickmore et al. (2005 ) in the Bacillus thuringiensis toxin nomenclature, online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or their insecticidal parts, e.g. proteins of the protein classes Cry Cry1Ab, CrylAc, Cry1B, Cry1D, Cry1F, Cry2Ab, Cry3Ae or Cry3Bb, or insecticidal portions thereof (e.g. EP-A 1999141 and WO 2007/107302), or such proteins encoded by synthetic genes as described for example in US patent application 12 / 249,016; or
2) a crystal protein from Bacillus thuringiensis or a part thereof which, in the presence of a second, different crystal protein than Bacillus thuringiensis, or a part thereof has an insecticidal effect, such as a binary toxin, which consists of the crystal proteins Cry34 and Cry35 (Moellenbeck et al., Nat. Biotechnol) (2001), 19, 668-72; Schnepf et al., Applied Environm. Microbiol. (2006), 71, 1765-1774), or a binary toxin that consists of a Cry1A or Cry1F protein and a Cry2Aa or Cry2Ab or Cry2Ae protein (US Patent Application 12 / 214,022 and EP 08010791.5); or
3) an insecticidal hybrid protein which comprises portions from two different insecticidal crystal proteins from Bacillus thuringiensis, such as for example a hybrid from the proteins in 1) above or a hybrid from the proteins in 2) above, e.g. the Cry1A.105 protein that is produced from corn event MON98034 (WO 2007/027777); or
4) a protein according to items 1) to 3) above, in which some amino acids, especially 1 to 10, have been replaced with other amino acids in order to achieve a higher insecticidal effectiveness against the target insect type and / or to broaden the spectrum of the respective target insect species and / or for changes that were induced in the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in maize MON863 or MON88017 event or the Cry3A protein in maize MIR 604 event; or
5) secreted insecticidal protein from Bacillus thuringiensis or Bacillus cereus or an insecticidal part thereof, such as vegetative insecticidal proteins (VIP) which are listed at http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore /Bt/vip.html, e.g. proteins of the VIP3Aa class of proteins; or
6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which, in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, has an insecticidal effect like a binary toxin which consists of the proteins VIP1A and VIP2A (WO 94/21795) or
7) an insecticidal hybrid protein that comprises portions of different secreted proteins from Bacillus thuringiensis or Bacillus cereus, as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or
8) a protein according to any one of items 5) to 7) above, in which some amino acids, especially 1 to 10, have been replaced with other amino acids to achieve a higher insecticidal efficacy against the target insect type and / or to broaden the spectrum of the respective target insect species and / or due to changes that have been induced in the encoding DNA during cloning or transformation (while the encoding of the insecticidal protein is retained), as the VIP3Aa protein in the COT 102 cotton event; or
9) a secreted protein from Bacillus thuringiensis or Bacillus cereus, which in the presence of a crystalline protein from Bacillus thuringiensis has an insecticidal effect in the same way as a binary toxin, which consists of the proteins VIP3 and Cry1A or Cry1F (patent applications Nos. 61/126083 and 61/195019), or a binary toxin that consists of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (US patent application 12 / 214,022 and EP 08010791.5); or
10) the protein according to 9) above, in which some amino acids, in particular 1 to 10, have been replaced with other amino acids in order to achieve a higher insecticidal effectiveness against the target insect type and / or to broaden the spectrum of the respective target insect species and / or due to changes that have been made. induced in the encoding DNA during cloning or transformation (while the encoding of the insecticidal protein is retained).
[0088] Naturally, insect-resistant transgenic plants in this context also include any plant which comprises a combination of genes which code for proteins from one of the classes 1 to 10 listed above. In one embodiment, the insect resistant plant comprises more than one transgene that codes for a protein according to one of the classes 1 to 10 mentioned above, to broaden the spectrum of the respective target insect species when different proteins are used to target different types of target insects, or to develop resistance. insects on plants by using different proteins that are insecticidal for the same target species, but have a different mode of action, like binding to various receptor binding sites in an insect.
[0089] The term "transgenic insect-resistant plants" in this context further includes any plant that contains at least one transgene that includes a coding sequence that, when expressed, produces a double-stranded RNA that, upon ingestion by an insect harmful to the plant, inhibits the growth of that harmful insect. as disclosed e.g. in WO 2007/080126, WO 2006/129204, WO 2007/074405, WO 2007/080127 and WO 2007/035650.
Plants or plant cultivars (which are obtained by plant biotechnology methods such as gene technology) which can be treated in the same way according to the invention are abiotic stress tolerant plants. Such plants may be obtained by genetic transformation or by selection of plants which contain a mutation which confers such stress resistance. Particularly useful stress tolerant plants include the following:
1) Plants which contain a transgene that can reduce the expression and / or activity of the poly (ADP-ribose) polymerase (PARP) gene in plant cells or plants as disclosed in WO 00/04173, WO / 2006/045633, EP 04077984.5 or EP 06009836.5.
2) Plants which contain a stress-promoting transgene that can reduce the expression and / or activity of a gene encoding a PARG of plants or plant cells, as disclosed e.g. in WO 2004/090140;
3) Plants that contain a stress-promoting transgene that encodes a plant functional enzyme of the nicotinamide adenine dinucleotide biosynthetic recovery pathway, including nicotinamide, nicotinate phosphoribosyltransferase, nicotinamide mononucleotide adenyltransferase, nicotinnamic mononucleotide adenyltransferase, or nicotinyl dinucleotinyl dinucleotide toxinyltransferase. 04077624.7, WO 2006/133827, PCT / EP07 / 002433, EP 1999263 or WO 2007/107326.
Plants or plant cultivars (which are obtained by plant biotechnology methods such as gene technology) which may be treated in the same way according to the invention have altered yield, quantity, quality and / or storage capacity and / or altered properties of specific crop components , such as:
1) Transgenic plants that synthesize a modified starch which, in terms of physicochemical properties, in particular amylose content or amylose / amylopectin ratio, degree of branching, average chain length, side chain distribution, viscosity behavior, gel stability, starch grain size and / or grain morphology starch as compared to starch synthesized in cells or plants of wild types of plants yes, that this modified starch is better suited for certain applications. These transgenic plants which synthesize modified starch are described, for example, in EP 0571427, WO 95/04826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO 03/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, US 6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01 / 98509, WO 01/98509, WO 2005/002359, US 5,824,790, US 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026 or WO 97/20936.
2) Transgenic plants that synthesize non-starch carbohydrate polymers, or non-starch carbohydrate polymers, the properties of which are altered compared to the wild type plant without genetic modification. Examples are plants that produce polyfructose, especially of the inulin and levan type, as described in EP 0663956, WO 96/01904, WO 96/21023, WO 98/39460 and WO 99/24593, plants that produce alpha-1,4 glucans as described in WO 95/31553, US 2002031826, US 6,284,479, US 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants which produce alpha-1,6 branched alpha-1,4-glucans as described in WO 00/73422 and plants which produce an alternan as described in WO 00/47727, WO 00/73422, EP 06077301.7, US 5,908,975 and EP 0728213.
3) Transgenic plants that produce hyaluronan as described for example in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006304779 and WO 2005/012529.
4) Transgenic or hybrid plants such as bulbs with characteristics such as 'high soluble solids content', 'low pungency' (means LP) and / or 'long storage' (means LS), as described in US Patent Applications 12 / 020,360 and 61 / 054,026.
Plants or plant cultivars (which are obtained by plant biotechnology methods such as gene technology) which can be treated in the same way according to the invention are cotton plants with altered fiber properties. Such plants may be obtained by genetic transformation or by selection of plants which contain a mutation which produces such altered fiber properties; they include:
a) plants, such as cotton plants, which contain an altered form of the cellulose synthase genes as disclosed in WO 98/00549,
b) plants, such as cotton plants, which contain an altered form of nucleic acids homologous to rsw2 or rsw3 as disclosed in WO 2004/053219;
c) plants such as cotton plants with increased expression of sucrose phosphate synthase as disclosed in WO 01/17333;
d) plants such as cotton plants with increased expression of sucrose synthase as disclosed in WO 02/45485;
e) plants, such as plants, such as cotton plants, in which the transmission gate control timing of the plasmodesmatic at the base of the fiber cell is altered, e.g. by reducing the activity of fiber-selective β-1,3-glucosinase as disclosed in WO 2005/017157, or in EP 08075514.3 or in US patent application 61 / 128,938;
f) plants such as cotton plants with altered fiber reactivity, e.g. by expressing N-acetylglucosamine transferase genes including also nodC and chitin synthase genes, as disclosed in WO 2006/136351.
Plants or plant cultivars (which are obtained by plant biotechnology methods such as gene technology) which may be treated in the same way according to the invention are plants such as rapeseed or related Brassica plants with altered oil composition properties. Such plants may be obtained by genetic transformation or by selection of plants which contain a mutation which gives such altered properties of the oil; they include:
a) plants such as rapeseed plants which produce an oil with a high oleic acid content, as for example disclosed in US 5,969,169, US 5,840,946 or US 6,323,392 or US 6,063,947;
b) plants such as rapeseed plants that produce oil with a low linolenic acid content as disclosed in US 6,270,828, US 6,169,190 or US 5,965,755.
c) plants such as rapeseed plants that produce an oil with a low content of saturated fatty acids as disclosed e.g. in US 5,434,283 or US patent application 12/668303.
Plants or plant cultivars (which are obtained by plant biotechnology methods such as gene technology) which can be treated in the same way according to the invention are plants such as oilseed rape or related Brassica plants with altered seeding properties. Such plants may be obtained by genetic transformation or by selecting plants which contain a mutation which confers such altered seeding properties; these include: rapeseed plants with delayed or reduced sowing, as disclosed in US Patent Application 61 / 135,230, WO09 / 068313 and WO10 / 006732.
[0095] Particularly useful transgenic plants that can be treated in accordance with the invention are plants that contain a transformation event, or a combination of a transformation event, and have been submitted for deregulation to the US Department of Animal and Plant Health Inspection Service (APHIS) for filing in the United States of America. Agriculture (USDA), whether or not such reports are approved or are still being processed. This information can be easily obtained from APHIS at any time (4700 River Road Riverdale, MD 20737, USA) from the website (URL http://www.aphis.usda.gov/brs/not_reg.html) for example. At the time of filing this notification, the deregulation requests that were developed by APHIS or that were authorized by APHIS were those listed in Table B, and this table contains the following information:
- Application: application identification number. Technical descriptions of the transformation events are in the individual application documents that can be obtained from APHIS by reference to their application numbers, for example on the APHIS website. Descriptions are incorporated into the following text by reference.
- Extension of an application: reference to a previous application for which an extension is requested.
- Institution: Applicant's name
- Subject of regulation: each type of plant.
- Transgenic phenotype: a trait conferred on a plant by a transformational event.
- Transform event or line: Name of the event or events (sometimes also called line (s)) for which deregulation is requested.
- APHIS documents: non-APHIS documents published against the application and available from APHIS.
[0096] Additional particularly useful plants that contain a single transformation event or a combination of transformation events are, for example, listed in the databanks of various national and regional offices (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http: //ceragmc.org/index.php?evidcode=&hstIDXCode=&gType=&AbbrCode=&atCode=&stCode=&c oIDCode = & action = gm_crop_database & mode = Submit).
[0097] Further particular transgenic plants include plants that contain the transgene in an agronomically neutral or favorable position, as disclosed in any of the patent publications that are given in Table C.
[0098] In a preferred embodiment of the invention, the plants A-1 to A-183 of Table A are fully or partially treated, or the propagation material of these plants is treated or brought into contact with the active ingredient combinations according to the invention either separately or in the form of compositions which are contain a combination of active substances.
<td>No</td><td>Transgenic event</td><td>Undertaking</td><td>Description</td><td>A cultivated plant</td>
<td>AND- 1</td><td>ASR368</td><td>Scotts Seeds</td><td>Glyphosate tolerance which was received by introduction of a modified, coding synthase 5- enolipyruvyl ano-shikimate-3-phosphate (EPSPS) gene from Agrobacterium tumefaciens, crossing site B99061.</td><td>Agrostis stolonifera white peppermint</td>
<td>A2</td><td>Asr-368</td><td></td><td>glyphosate tolerance; US 2006162007</td><td>broom</td>
<td>AND- 3</td><td>H7-1</td><td>Monsanto Company</td><td>Sugar beet tolerant to the herbicide glyphosate; production by inserting a gene for the enzyme synthase 5- enolipyrvyloshikimato-3-phosphate (EPSPS) with</td><td>Beta vulgaris</td>
<td></td><td></td><td></td><td>Agrobacterium tumefaciens strain CP4; WO 2004-074492</td><td></td>
<td>AND- 4</td><td>T120-7</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Introducing the gene PPT acetyltransferase (PAT) from Streptomyces viridochromogenes, an aerobic soil bacterium. Usually, PPT works by inhibiting the synthetase glutamine, which leads to a fatal build-up of ammonia. Acetylated PPT is inactive.</td><td>Beta vulgaris</td>
<td>A5</td><td>GTSB77</td><td>Novartis Seeds; Monsanto Company</td><td>Sugar beet tolerant to the herbicide glyphosate; production by inserting a gene for the enzyme synthase 5- enolipyrvyloshikimato-3-phosphate (EPSPS) with Agrobacterium tumefaciens strain CP4.</td><td>Beta vulgaris (sugar beet)</td>
<td>AND- 6</td><td>T227-1</td><td></td><td>glyphosate tolerance; US 2004117870</td><td>Beta vulgaris sugar beet</td>
<td>AND- 7</td><td> 23-18-17, 23198</td><td>Monsanto Company (formerly Calgene)</td><td>Canola rape with a high content of lauric acid (12: 0) and myristic acid (14: 0); Produced by insertion of the gene for California laurel thioesterase (Umbellularia californica).</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>A8</td><td>45A37,46A40</td><td>Pioneer Hi-Bred International Inc.</td><td>Canola rape with high oleic acid content and low acid content linolenic; Manufacture by chemical combination mutagenesis for selection for fatty acid desaturase mutants with increased oleic acid content and</td><td>Brassica napus (Argentine Canola Rape)</td>
<td></td><td></td><td></td><td>traditional crossover to introduce the low linolenic acid feature,</td><td></td>
<td>AND- 9</td><td>46A12,46A16</td><td>Pioneer Hi-Bred International Inc.</td><td>Combination of mutagenesis chemical to produce high oleic acid traits and traditional breeding with introduced varieties Canola rape.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 10</td><td>GT200</td><td>Monsanto Company</td><td>Canola oilseed rape tolerant to the herbicide glyphosate; production by inserting genes for the enzyme synthase 5- enolipyruv ano-shikimate-3-phosphate (EPSPS) with Agrobacterium tumefaciens strain CP4 and glyphosate oxidase from Ochrobactrum anthropi.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 11</td><td>GT73, RT73</td><td>Monsanto Company</td><td>Canola oilseed rape tolerant to the herbicide glyphosate; production by inserting genes for the enzyme synthase 5- enolipyruv ano-shikimate-3-phosphate (EPSPS) with Agrobacterium tumefaciens strain CP4 and glyphosate oxidase from Ochrobactrum anthropi.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 12</td><td>HCN10</td><td>Aventis CropScience</td><td>Introducing the gene PPT acetyltransferase (PAT) from Streptomyces viridochromogenes, an aerobic soil bacterium. Usually, PPT works by inhibiting the synthetase glutamine, which leads to a fatal build-up of ammonia. Acetylated PPT is inactive.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND-</td><td>HCN92</td><td>Bayer CropScience</td><td>Introducing the gene acetyltransferase PPT (PAT) with</td><td>Brassica napus</td>
<td> 13</td><td></td><td>(Aventis CropScience (AgrEvo))</td><td>Streptomyces viridochromogenes, an aerobic soil bacterium. Usually, PPT works by inhibiting the synthetase glutamine, which leads to a fatal build-up of ammonia. Acetylated PPT is inactive.</td><td>(Argentine Canola rape)</td>
<td>AND- 14</td><td>MS1, RF1 => PGS1</td><td>Aventis CropScience (formerly Plant Genetic Systems)</td><td>male sterility / fertility restoration / control system pollination tolerant to the herbicide glufosinate. The MS lines contained the Bernase gene from Bacillus amyloliquefaciens, the RF lines contained the Barstar gene from the same bacteria, and both lines contained the gene for phosphinothricin N-acetyltransferase (PAT) from Streptomyces hygroscopicus.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 15</td><td>MS1, RF2 => PGS2</td><td>Aventis CropScience (formerly Plant Genetic Systems)</td><td>male sterility / fertility restoration / control system pollination tolerant to the herbicide glufosinate. The MS lines contained the Bernase gene from Bacillus amyloliquefaciens, the RF lines contained the Barstar gene from the same bacteria, and both lines contained the gene for phosphinothricin N-acetyltransferase (PAT) from Streptomyces hygroscopicus.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 16</td><td>MS8xRF3</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>male sterility / fertility restoration / control system pollination tolerant to the herbicide glufosinate. The MS lines contained the Bernase gene from Bacillus amyloliquefaciens, the RF lines contained the Barstar gene from the same bacteria, and both lines contained the gene for phosphinothricin N-acetyltransferase (PAT) from</td><td>Brassica napus (Argentine Canola Rape)</td>
<td></td><td></td><td></td><td>Streptomyces hygroscopicus.</td><td></td>
<td>AND- 17</td><td>MS-B2</td><td></td><td>male sterility; WO 01/31042</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 18</td><td>MS-BN1 / RF- BN1</td><td></td><td>male sterility / restoration WO 01/41558</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 19</td><td>NS738, NS1471, NS1473</td><td>Pioneer Hi-Bred International Inc.</td><td>Somaclonal selection variants with altered synthase enzymes acetolactate (ALS) and sequentially chemical mutagenesis. Two lines (P1, P2) from modifications to different, unconjugated loci. NS738 only contains the P2 mutation.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- twenty</td><td>ΟΧΥ-235</td><td>Aventis CropScience (formerly Rhone Poulenc Inc.)</td><td>Herbicide tolerance bromoxynil and ioxynil by incorporation of the nitrilase gene from Klebsiella pneumoniae.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 21</td><td>PHY14, PHY35</td><td>Aventis CropScience (formerly Plant Genetic Systems)</td><td>Generation of male sterility by introducing the barnase ribonuclease gene from Bacillus amyloliquefaciens; restoration of fertility by introducing a Barstar-RNAse inhibitor; resistance to PPT by PPT acetyltransferase (PAT) from Streptomyces hygroscopicus.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 22</td><td>PHY36</td><td>Aventis CropScience (formerly Plant</td><td>Manufacture of male sterility by introducing the Bacillus barnase ribonuclease gene</td><td>Brassica napus (Argentine</td>
<td></td><td></td><td>Genetic Systems)</td><td>amyloliquefaciens; restoration of fertility by introducing a Barstar-RNAse inhibitor; PPT acetyltransferase (PAT) from Streptomyces hygroscopicus.</td><td>Canola oilseed rape)</td>
<td>AND- 23</td><td>RT73</td><td></td><td>glyphosate resistance; WO 02/36831</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 24</td><td>T45 (HCN28)</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Introduction of a gene encoding PPT acetyltransferase (PAT) from Streptomyces viridochromogenes, an aerobic soil bacterium. Usually, PPT works by inhibiting the synthetase glutamine, which leads to a fatal build-up of ammonia. Acetylated PPT is inactive.</td><td>Brassica napus (Argentine Canola Rape)</td>
<td>AND- 25</td><td>HCR-1</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Introduction of the tolerance feature to the herbicide glufosinate ammonium from the transgenic line of B. napus T45. This trait has been given by the gene for acetyltransferase phosphinothricin (PAT) from S. viriochromogene p.</td><td>Brassica rapa (Polish Canola rape)</td>
<td>AND- 26</td><td>ZSR500 / 502</td><td>Monsanto Company</td><td>Introduction of modified 5-enolpyruvate synthase shikimo-3-phosphate (EPSPS) and the gene from the Achromobacter species that degrades glyphosate by conversion to aminomethylphosphonic acid (AMPA) and glyoxylates, using a junction of a genus with GT73.</td><td>Brassica rapa (Polish Canola rape)</td>
<td>AND- 27</td><td>EE-1</td><td></td><td>insect resistance (Cry1Ac); WO 2007/091277</td><td>eggplant</td>
<td>AND- 28</td><td> 55-1/63-1</td><td>Cornell University</td><td>Papaya resistant to papaya ringspot virus (PRSV), which was generated by insertion of envelope protein (CP) coding sequences from this plant potyvirus.</td><td>Carica papaya (papaya)</td>
<td>AND- 29</td><td>RM3-3, RM3- 4, RM3-6</td><td>Bejo Zaden BV</td><td>Generation of male sterility by introducing the barnase ribonuclease gene from Bacillus amyloliquefaciens; resistance to PPT using the bar gene from Streptomyces hygroscopicus, which encodes the PAT enzyme.</td><td>Cichorium intybus (chicory)</td>
<td>AND- thirty</td><td>A, B</td><td>Agritope Inc.</td><td>Reduced accumulation of Sadenosylmethionine (SAM) and thus reduced ethylene synthesis, by insertion of the gene encoding S- hydrolase adenosylmethionine.</td><td>Cucumis melo (melon)</td>
<td>AND- 31</td><td>THU-3</td><td>Asgrow (USA); Seminis Vegetable Inc. (Canada)</td><td>Pumpkin (Curcurbita pepo) resistant to cucumber mosaic virus (CMV), zucchini yellow mosaic virus (ZYMV) and watermelon mosaic virus (WMV) 2; Production by introducing a sequence encoding an envelope protein (CP) of each of these plant viruses into the host genome.</td><td>Cucurbita pepo (pumpkin)</td>
<td>AND- 32</td><td>ZW20</td><td>Upjohn (USA); Seminis Vegetable Inc. (Canada)</td><td>Pumpkin (Curcurbita pepo) resistant to zucchini yellow mosaic virus (ZYMV) and watermelon mosaic virus (WMV) 2; Production by introducing a sequence encoding an envelope protein (CP) of each of these plant potyviruses into the genome the host.</td><td>Cucurbita pepo (pumpkin)</td>
<td>AND-</td><td> 66</td><td>Florigene Pty Ltd.</td><td>Cloves tolerant to delayed sulfonylurea</td><td>Dianthus caryophyllus</td>
<td> 33</td><td></td><td></td><td>menopause; Generation by insertion of a truncated copy of the cyclase synthase gene aminocyclopropane (ACC) with a clove for suppression endogenous expression an unmodified gene that is required for the proper biosynthesis of ethylene. Tolerance to sulfonylurea herbicides was made by introducing a version of the acetolactate synthase (ALS) gene, tolerant of chlorsulfuron, from tobacco.</td><td>(carnation)</td>
<td>AND- 34</td><td> 4,11,15,16</td><td>Florigene Pty Ltd.</td><td>Cloves tolerant to sulfonylurea o modified color, which is produced by the insertion of two genes anthocyanin biosynthesis, the expression of which leads to purple discoloration / mallow color. Tolerance to sulfonylurea herbicides has remained produced by introducing a version of the synthase gene acetolactate (ALS) tolerant of chlorsulfuron, from tobacco.</td><td>Dianthus caryophyllus (carnation)</td>
<td>AND- 35</td><td>959A, 988A, 1226A, 1351A, 1363A, 1400A</td><td>Florigene Pty Ltd.</td><td>Introduction of two anthocyanin biosynthetic genes that lead to purple / mallow staining; introduction of a synthase variant acetolactate acid (ALS).</td><td>Dianthus caryophyllus (carnation)</td>
<td>AND- 36</td><td> 3560.4.3.5</td><td></td><td>tolerance to glyphosate / ALS inhibitors; WO 2008002872</td><td>Glycine max L. (soybeans)</td>
<td>AND-</td><td>A2704-12</td><td></td><td>tolerance to glufosinates; WO</td><td>Glycine max</td>
<td> 37</td><td></td><td></td><td> 2006/108674</td><td>L. (soybeans)</td>
<td>AND- 38</td><td>A2704-12, A2704-21, A5547-35</td><td>Aventis CropScience</td><td>Soybeans tolerant to the herbicide glufosinate ammonium; production by introducing a modified gene for phosphinothricin acetyltransferase (PAT) from the soil bacterium Streptomyces viridochromogenes.</td><td>Glycine max L. (soybeans)</td>
<td>AND- 39</td><td>A5547-127</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Soybeans tolerant to the herbicide glufosinate ammonium; production by introducing a modified gene for phosphinothricin acetyltransferase (PAT) from the soil bacterium Streptomyces viridochromogenes.</td><td>Glycine max L. (soybeans)</td>
<td>AND- 40</td><td>A5547-35</td><td></td><td>tolerance to glufosinates; WO 2006/108675</td><td>Glycine max L. (soybeans)</td>
<td>AND- 41</td><td>DP-305423-1</td><td></td><td>High acid content oleic / tolerance to ALS inhibitors; WO 2008/054747</td><td>Glycine max L. (soybeans)</td>
<td>AND- 42</td><td>DP356043</td><td>Pioneer Hi-Bred International Inc.</td><td>An event in soybeans with two herbicide tolerance genes: Glyphosate N-acetyltransferase, glyphosate detoxifying as well as modified synthase acetolactate (A</td><td>Glycine max L. (soybeans)</td>
<td>AND- 43</td><td>G94-1, G94-19, G168</td><td>DuPont Canada Agricultural Products</td><td>Soybean high in oleic acid; Generation by insertion of a second copy of the acid desaturase gene The fatty acid (GmFad2-1) from soybeans, which resulted in "shutdown" of the host's endogenous gene.</td><td>Glycine max L. (soybeans)</td>
<td>AND- 44</td><td>GTS 40-3-2</td><td>Monsanto Company</td><td>Glyphosate tolerant soybean variety; Manufacture by introducing a modified one</td><td>Glycine max L. (soybeans)</td>
<td></td><td></td><td></td><td>the gene for synthase 5- enolipyruvate ano-shikim-3-phosphate (EPSPS) from the soil bacterium Agrobacterium tumefaciens.</td><td></td>
<td>AND- 45</td><td>GU262</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Soybean tolerant to the herbicide glufosinate ammonium; production by introducing a modified gene for phosphinothricin acetyltransferase (PAT) from the soil bacterium Streptomyces viridochromogenes.</td><td>Glycine max L. (soybeans)</td>
<td>AND- 46</td><td>MON87701</td><td></td><td>insect resistance (Cry1Ac); WO 2009064652</td><td>Glycine max L. (soybeans)</td>
<td>AND- 47</td><td>MON87705</td><td></td><td>altered levels of fatty acids (medium oleic acid and low saturated acid); WO 2010037016</td><td>Glycine max L. (soybeans)</td>
<td>AND- 48</td><td>MON87754</td><td></td><td>increased oil content; WO 2010024976</td><td>Glycine max L. (soybeans)</td>
<td>AND- 49</td><td>MON87769</td><td></td><td>acid-containing oil stearidone (SDA); WO 2009102873</td><td>Glycine max L. (soybeans)</td>
<td>AND- 50</td><td>MON89788</td><td>Monsanto Company</td><td>Glyphosate tolerant soybean variety; Generation by insertion of a modified aroA (epsps) gene for 5-enolpyruvyl ano-shikima-3-phosphate synthase (EPSPS) from Agrobacterium tumefaciens CP4; WO 2006130436</td><td>Glycine max L. (soybeans)</td>
<td>AND- 51</td><td>OT96-15</td><td>Agriculture & Agri-Food Canada</td><td>Soybean low in linolenic acid; Produced by traditional crossing by building a new trait from a naturally occurring one fanl gene mutants that</td><td>Glycine max L. (soybeans)</td>
<td></td><td></td><td></td><td>selected for low acid content linolenic.</td><td></td>
<td>AND- 52</td><td>W62, W98</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Soybeans tolerant to the herbicide glufosinate ammonium; production by introducing a modified gene for phosphinothricin acetyltransferase (PAT) from the soil bacterium Streptomyces hygroscopicus.</td><td>Glycine max L. (soybeans)</td>
<td>AND- 53</td><td> 15985</td><td>Monsanto Company</td><td>Insect-resistant cotton; derivation by variety transformation parental DP50B, event 531 (expressing the CrylAc protein), with purified plasmid DNA that contains the cry2Ab gene from B. thuringiensis subspecies kurstaki.</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 54</td><td>1143-14A</td><td></td><td>insect resistance (Cry1Ab); WO 2006/128569</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 55</td><td>1143-51B</td><td></td><td>insect resistance (Cry1Ab); WO 2006/128570</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 56</td><td>19-51A</td><td>DuPont Canada Agricultural Products</td><td>Introduction of a variant of acetolactate synthase (ALS).</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 57</td><td> 281-24-236</td><td>DOW AgroSciences LLC</td><td>Insect resistant cotton; production by inserting the cry1F gene from Bacillus thuringiensis aizawai. The gene for PAT from Streptomyces viridochromogenes was introduced as a selectable marker.</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 58</td><td> 3006-210-23</td><td>DOW AgroSciences LLC</td><td>Insect resistant cotton; production by insertion of the cry1Ac gene from Bacillus</td><td>Gossypium hirsutum L. (cotton)</td>
<td></td><td></td><td></td><td>thuringiensis kurstaki. The gene for PAT from Streptomyces viridochromogenes was introduced as a selectable marker.</td><td></td>
<td>AND- 59</td><td> 31807/31808</td><td>Calgene Inc.</td><td>Insect resistant cotton with herbicide tolerance bromoxynil; production by insertion of the cry1Ac gene from Bacillus thuringiensis and the gene for nitrilase from Klebsiella pneumoniae.</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 60</td><td>BXN</td><td>Calgene Inc.</td><td>Cotton with a tolerance to the herbicide bromoxynil; production by insertion of a gene for nitrilase from Klebsiella pneumoniae.</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 61</td><td>CE43-67B</td><td></td><td>insect resistance (Cry1Ab); WO 2006/128573</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 62</td><td>CE44-69D</td><td></td><td>insect resistance (Cry1Ab); WO 2006/128571</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 63</td><td>CE46-02A</td><td></td><td>insect resistance (Cry1Ab); WO 2006/128572</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 64</td><td>Cot102</td><td></td><td>insect resistance (Vip3A); US 2006-130175</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 65</td><td>COT102</td><td>Syngenta Seeds, Inc.</td><td>Insect resistant cotton; production by inserting the vip3A (a) gene from Bacillus thuringiensis AB88. The gene encoding APH4 from E. coli was introduced as a selectable marker.</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 66</td><td>COT202</td><td></td><td>insect resistance (VIP3A); US2009181399</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 67</td><td>Cot202</td><td></td><td>insect resistance (VIP3A); US 2007-067868</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 68</td><td>DAS-21023-5 x DAS-24236-5</td><td>DOW AgroSciences LLC</td><td>WideStrike ™, cotton with a combination of insect resistance; derivation through the traditional crossing of the parent lines 3006-210-23 (OECD code: DAS-21023-5) and 281-24-236 (OECD code: DAS-242365).</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 69</td><td>DAS-21023-5 x DAS-24236-5 x MON88913</td><td>DOW AgroSciences LLC and Pioneer HiBred International Inc.</td><td>Cotton with a combination of insect resistance and glyphosate tolerance; production by traditional crossing of WideStrike cotton (OECD code: DAS-21023-5 x DAS-24236-5) with MON88913, known as RoundupReady Flex (OECD code: MON88913-8).</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 70</td><td>DAS-21023-5 x DAS-24236-5 x MON-01445- 2</td><td>DOW AgroSciences LLC</td><td>WideStrike ™ / Roundup Ready® cotton, cotton with a combination of insect resistance and glyphosate tolerance; produced by traditional crossing of WideStrike cotton (OECD code: DAS-21023-5 x DAS-24236-5) with MON1445 (OECD code: MON-01445-2).</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 71</td><td>EE-GH3</td><td></td><td>glyphosate tolerance; WO 2007/017186</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 72</td><td>EE-GH5</td><td></td><td>insect resistance (Cry1Ab); WO 2008/122406</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 73</td><td>EE-GH6</td><td></td><td>insect resistance (cry2Ae); WO2008151780</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 74</td><td>event 28124-236</td><td></td><td>insect resistance (Cry1F); WO 2005/103266</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 75</td><td>event 3006- 210-23</td><td></td><td>insect resistance (Cry1Ac); WO 2005/103266</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 76</td><td>GBH614</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Cotton with glyphosate herbicide tolerance; production by introducing the 2MEPSPS gene into cultivar Coker312 with Agrobacterium, under the control of Ph4a748At and TpotpC.</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 77</td><td>LLCotton25</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Cotton tolerant to the herbicide glufosinate ammonium; production by introducing a modified gene for phosphinotricin acetyltransferase (PAT) from the soil bacterium Streptomyces hygroscopicus; WO 2003013224</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 78</td><td>LLCotton25 x MON15985</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Cotton with a combination of herbicide tolerance and insect resistance; where tolerance to the herbicide glufosinate ammonium from LLCotton25 (OECD code: ACS-GH001-3) is in combination with insect resistance with MON15985 (OECD code: MON-15985-7).</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 79</td><td>MON 15985</td><td></td><td>insect resistance (Cry1A / Cry2Ab); US 2004- 250317</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 80</td><td>MON1445 / 169 8</td><td>Monsanto Company</td><td>Cotton with glyphosate herbicide tolerance; production by introducing natural the glyphosate-tolerant form of the enzyme synthase 5 enolipiruwyloshikimato-3 -</td><td>Gossypium hirsutum L. (cotton)</td>
<td></td><td></td><td></td><td>phosphate (EPSPS) from A. tumefaciens strain CP4.</td><td></td>
<td>AND- 81</td><td>MON15985 x MON88913</td><td>Monsanto Company</td><td>Cotton with a combination of insect resistance and glyphosate tolerance; production by traditional cotton crossing parent lines MON88913 (OECD reference: MON-889138) of 15985, (OECD reference: MON-15985-7). Glyphosate tolerance comes from the MON88913 lineage which contains two genes that encode the enzyme 5-enolipyrvylshikimato-3-phosphate synthase (EPSPS) from Agrobacterium tumefaciens strain CP4. The insect-resistant cotton comes from the MON15985 line which was made by variety transformation parental DP50B, which contains event 531 (CrylAc protein expression), with purified plasmid DNA that contains the cry2Ab gene from B. thuringiensis subspecies kurstaki.</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 82</td><td>MON-15985-7 x MON-014452</td><td>Monsanto Company</td><td>Cotton with a combination of insect resistance and herbicide tolerance; production by traditional cotton crossing parent lines 15985 (OECD designation: MON-15985-7) and MON1445, (OECD designation: MON01445-2).</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 83</td><td>MON531 / 757 / 1076</td><td>Monsanto Company</td><td>Insect resistant cotton: production by insertion of the cry1Ac gene from Bacillus thuringiensis subspecies kurstaki HD-73 (Btk).</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 84</td><td>MON88913</td><td>Monsanto Company</td><td>Cotton with glyphosate herbicide tolerance; production by inserting two genes for the enzyme synthase 5- enolipyrvyloshikimato-3-phosphate (EPSPS) with Agrobacterium tumefaciens strain CP4; WO 2004/072235</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 85</td><td>MON-00531-6 x MON-014452</td><td>Monsanto Company</td><td>Cotton with a combination of insect resistance and herbicide tolerance; Manufacture by traditional cotton crossing the lines are born into MON531 (OECD reference number: MON00531-6) and MON-1445, (OECD reference: MON-014452).</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 86</td><td>PV-GHGT07 (1445)</td><td></td><td>glyphosate tolerance; US 2004148666</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 87</td><td>T304-40</td><td></td><td>insect resistance (Cry1Ab); WO2008 / 122406</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 88</td><td>T342-142</td><td></td><td>insect resistance (Cry1Ab); WO 2006/128568</td><td>Gossypium hirsutum L. (cotton)</td>
<td>AND- 89</td><td>Χ81359</td><td>BASF Inc.</td><td>Herbicide tolerance imidazolinone by selecting relative to naturally occurring mutants.</td><td>Helianthus annuus (sunflower)</td>
<td>AND- 90</td><td>RH44</td><td>BASF Inc.</td><td>Selection towards a mutagenized version of the enzyme acetohydroxy acid synthase (AHAS), also known as synthase acetolactate (ALS) or lyase</td><td>Lens culinaris (lentils)</td>
<td></td><td></td><td></td><td>acetolactate pyruvate.</td><td></td>
<td>AND- 91</td><td>FP967</td><td>University of Saskatchewan, Crop Dev. Center</td><td>Synthase variant acetolactate (ALS) obtained from A. thaliana chlorsulfuron tolerance line and used for flax transformation.</td><td>Linum usitatissimum L. (flax)</td>
<td>AND- 92</td><td> 5345</td><td>Monsanto Company</td><td>Resistance to lepidopteran pests by introducing the cry1Ac gene from Bacillus thuringiensis subspecies kurstaki.</td><td>Lycopersicon esculentum (tomato)</td>
<td>AND- 93</td><td> 8338</td><td>Monsanto Company</td><td>Entering a sequence gene that encodes the enzyme acid deamidase 1- aminocyclopropane-1 carboxylic acid (ACCd), which metabolizes the precursor of the fruit ripening hormone ethylene.</td><td>Lycopersicon esculentum (tomato)</td>
<td>AND- 94</td><td> 1345-4</td><td>DNA Plant Technology Corporation</td><td>Tomatoes delayed The maturation was generated by introducing additional copies of the truncated gene for 1-aminocyclopropane-1-carboxylic acid synthase (ACC), leading to a reduction in endogenous ACC synthase and reduced ethylene accumulation.</td><td>Lycopersicon esculentum (tomato)</td>
<td>AND- 95</td><td>35 1 N.</td><td>Agritope Inc.</td><td>Entering a sequence gene that encodes the enzyme S- hydrolase adenosylmethionine, which metabolizes the precursor of the fruit ripening hormone - ethylene.</td><td>Lycopersicon esculentum (tomato)</td>
<td>AND- 96</td><td>B, Da, F</td><td>Zeneca Seeds</td><td>Tomatoes delayed softening was produced by introducing a truncated version of the gene for polygalacturonase (PG) in sense orientation or antisense, to reduce</td><td>Lycopersicon esculentum (tomato)</td>
<td></td><td></td><td></td><td>endogenous PG gene expression and thus reducing pectin degradation.</td><td></td>
<td>AND- 97</td><td>FLAVR SAVR</td><td>Calgene Inc.</td><td>Tomatoes delayed softening was produced by introducing an additional gene copy for polygalacturonase (PG) in the sense orientation or antisense, to reduce the expression of the endogenous PG gene and to thus reduce pectin degradation.</td><td>Lycopersicon esculentum (tomato)</td>
<td>AND- 98</td><td>J101, J163</td><td>Monsanto Company and Forage Genetics International</td><td>Alfalfa tolerant to the herbicide glyphosate; is produced by inserting a gene for the enzyme 5-enolipyrvylshikimato3-phosphate synthase (EPSPS) from Agrobacterium tumefaciens strain CP4.</td><td>Medicago sativa (alfalfa)</td>
<td>AND- 99</td><td>C / F / 93 / 08-02</td><td>Societe National d'Exploitation des Tabacs et Allumettes</td><td>Herbicide tolerance bromoxynil and ioxynil by incorporation of the nitrilase genes from Klebsiella pneumoniae.</td><td>Nicotiana tabacum L. (tobacco)</td>
<td>AND- 100</td><td>vector 21-41</td><td>Vector Tobacco Inc.</td><td>Reduced nicotine content by introducing a second copy of the acid phosphoryl transferase quinoline (QTPase) from tobacco in antisense orientation. The gene encoding NPTII from E. coli was introduced as a selectable marker for identifying transformants.</td><td>Nicotiana tabacum L. (tobacco)</td>
<td>AND- 101</td><td>CL121, CL141, CFX51</td><td>BASF Inc.</td><td>Herbicide tolerance limidazolinone imazethapyr was caused by chemical mutagenesis of the enzyme acetolactate synthase (ALS) with ethyl methanesulfonate</td><td>Oryza sativa (rice)</td>
<td></td><td></td><td></td><td>(EMS).</td><td></td>
<td>AND- 102</td><td>GAT-OS2</td><td></td><td>tolerance to glufosinate; WO 01/83818</td><td>Oryza sativa (rice)</td>
<td>AND- 103</td><td>GAT-OS3</td><td></td><td>glyphosate tolerance; US 2008289060</td><td>Oryza sativa (rice)</td>
<td>AND- 104</td><td>IMINTA-1, IMINTA-4</td><td>BASF Inc.</td><td>Herbicide tolerance the imidazolinone was left caused by chemical synthase enzyme mutagenesis acetolactate acid (ALS) too with sodium azide.</td><td>Oryza sativa <sup>(r</sup>yż)</td>
<td>AND- 105</td><td>LLRICE06, LLRICE62</td><td>Aventis CropScience</td><td>Rice tolerant to the herbicide glufosinate ammonium; production by introducing the modified gene for phosphinothricin acetyltransferase (PAT) from the soil bacterium Streptomyces hygroscopicus).</td><td>Oryza sativa (rice)</td>
<td>AND- 106</td><td>LLRICE601</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Rice tolerant to the herbicide glufosinate ammonium; production by introducing the modified gene for phosphinothricin acetyltransferase (PAT) from the soil bacterium Streptomyces hygroscopicus).</td><td>Oryza sativa <sup>(r</sup>yż)</td>
<td>AND- 107</td><td>PE-7</td><td></td><td>insect resistance (Cry1Ac); WO 2008/114282</td><td>Oryza sativa (rice)</td>
<td>AND- 108</td><td>PWC16</td><td>BASF Inc.</td><td>Herbicide tolerance imidazolinone imazethapyr was caused by chemical mutagenesis of the enzyme acetolactate synthase (ALS) with ethyl methanesulfonate (EMS).</td><td>Oryza sativa <sup>(r</sup>yż)</td>
<td>AND- 109</td><td>TT51</td><td></td><td>insect resistance (Cry1Ab / Cry1Ac); CN184065</td><td>Oryza sativa <sup>(r</sup>yż)</td>
<td>AND- 110</td><td>C5</td><td>United States Department of Agriculture Agricultural Research Service</td><td>Plum with resistance to Plum pox virus (PPV), produced by Agrobacterium-mediated transformation the envelope protein (CP) gene of the virus.</td><td>Prunus domestica (plum)</td>
<td></td><td>EH92-527</td><td>BASF Plant Science</td><td>Yield composition; Amflora; EU marking only: BPS25271-9</td><td></td>
<td>AND- 111</td><td>ATBT04-6, ATBT04-27, ATBT04-30, ATBT04-31, ATBT04-36, SPBT02-5, SPBT02-7</td><td>Monsanto Company</td><td>Colorado potato beetle resistant potatoes produced by insertion of the cry3A gene from Bacillus thuringiensis (tenebrionis subspecies).</td><td>Solanum tuberosum L. (potato)</td>
<td>AND- 112</td><td>BT6, BT10, BT12, BT16, BT17, BT18, BT23</td><td>Monsanto Company</td><td>Colorado potato beetle resistant potatoes produced by insertion of the cry3A gene from Bacillus thuringiensis (tenebrionis subspecies).</td><td>Solanum tuberosum L. (potato)</td>
<td>AND- 113</td><td>RBMT15-101, SEMT15-02, SEMT15-15</td><td>Monsanto Company</td><td>Potatoes with resistance to Colorado potato beetle and potato virus Y (PVY); production by insertion of the cry3A gene from Bacillus thuringiensis (tenebrionis subspecies) and the PVY gene for envelope protein.</td><td>Solanum tuberosum L. (potato)</td>
<td>AND- 114</td><td>RBMT21-129, RBMT21-350, RBMT22-082</td><td>Monsanto Company</td><td>Potatoes with resistance to Colorado potato beetle and potato leaf roll virus (PLRV); production by insertion of the cry3A gene from Bacillus thuringiensis (tenebrionis subspecies) and the PLRV gene for replicase.</td><td>Solanum tuberosum L. (potato)</td>
<td>AND- 115</td><td>AP205CL</td><td>BASF Inc.</td><td>Selection towards a mutagenized version of the enzyme acetohydroxy acid synthase (AHAS), also known as</td><td>Triticum aestivum (wheat)</td>
<td></td><td></td><td></td><td>the name of the synthase acetolactate (ALS) or acetolactate pyruvate lyase.</td><td></td>
<td>AND- 116</td><td>AP602CL</td><td>BASF Inc.</td><td>Selection towards a mutagenized version of the enzyme acetohydroxy acid synthase (AHAS), also known as synthase acetolactate (ALS) or acetolactate pyruvate lyase.</td><td>Triticum aestivum (wheat)</td>
<td>AND- 117</td><td>BW255-2, BW238-3</td><td>BASF Inc.</td><td>Selection towards a mutagenized version of the enzyme acetohydroxy acid synthase (AHAS), also known as synthase acetolactate (ALS) or acetolactate pyruvate lyase.</td><td>Triticum aestivum (wheat)</td>
<td>AND- 118</td><td>BW7</td><td>BASF Inc.</td><td>Herbicide tolerance imidazolinone compounds caused by chemical mutagenesis of the acetohydroxy acid synthase gene (AHAS) by the use of sodium azide.</td><td>Triticum aestivum (wheat)</td>
<td>AND- 119</td><td>event 1</td><td></td><td>Fusarium resistance (trichotekene-3-O- transferase cetyl); CA 2561992</td><td>Triticum aestivum (wheat)</td>
<td>AND- 120</td><td>JOPLIN1</td><td></td><td>resistance to moss (fungus) (trichotekene-3 -O- acetyltransferase); US 2008064032</td><td>Triticum aestivum (wheat)</td>
<td>AND- 121</td><td>MON71800</td><td>Monsanto Company</td><td>Glyphosate tolerant wheat variety; Production by insertion of a modified gene for synthase 5- enolipyruvate-shikimowo-3-</td><td>Triticum aestivum (wheat)</td>
<td></td><td></td><td></td><td>phosphate (EPSPS) from the soil bacterium Agrobacterium tumefaciens strain CP4.</td><td></td>
<td>AND- 122</td><td>SWP965001</td><td>Cyanamid Crop Protection</td><td>Selection towards a mutagenized version of the enzyme acetohydroxy acid synthase (AHAS), also known as synthase acetolactate (ALS) or acetolactate pyruvate lyase.</td><td>Triticum aestivum (wheat)</td>
<td>AND- 123</td><td>Teal 11A</td><td>BASF Inc.</td><td>Selection towards a mutagenized version of the enzyme acetohydroxy acid synthase (AHAS), also known as synthase acetolactate (ALS) or acetolactate pyruvate lyase.</td><td>Triticum aestivum (wheat)</td>
<td>AND- 124</td><td> 176</td><td>Syngenta Seeds, Inc.</td><td>Insect resistant maize; production by insertion of the cry1Ab gene from Bacillus thuringiensis subspecies kurstaki. Genetic modification confers resistance to damage by the European corn borer.</td><td>Zea mays L. (maize)</td>
<td>AND- 125</td><td> 3272</td><td></td><td>self-processing maize (alpha amylase); US 2006-230473</td><td>Zea mays L. (maize)</td>
<td>AND- 126</td><td>3751IR</td><td>Pioneer Hi-Bred International Inc.</td><td>Selection of variants somaclonal processes by culturing embryos on imidazolinone-containing media.</td><td>Zea mays L. (maize)</td>
<td>AND- 127</td><td> 676,678,680</td><td>Pioneer Hi-Bred International Inc.</td><td>Male sterile maize tolerant to the herbicide glufosinate ammonium; production by introduction of a modified gene for DNA adenomethylase and phosphinothricin acetyltransferase</td><td>Zea mays L. (maize)</td>
<td></td><td></td><td></td><td>(PAT) from Escherichia coli or Streptomyces viridochromogenes.</td><td></td>
<td>AND- 128</td><td>ACS-ZM003- 2 x MON00810-6</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Hybrid corn with a combination of insect resistance and herbicide tolerance; derivation by traditional crossing of parental lines T25 (OECD code: ACSZM003-2) and MON810 (OECD reference: MON00810-6).</td><td>Zea mays L. (maize)</td>
<td>AND- 129</td><td>B16</td><td></td><td>resistance to glufosinate; US 2003-126634</td><td>Zea mays L. (maize)</td>
<td>AND- 130</td><td>B16 (DLL25)</td><td>Dekalb Genetics Corporation</td><td>Maize tolerant to the herbicide glufosinate ammonium; production by insertion of a modified gene for phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus.</td><td>Zea mays L. (maize)</td>
<td>AND- 131</td><td>BT11 (X4334CBR, X4734CBR)</td><td>Syngenta Seeds, Inc.</td><td>Insect resistant and herbicide tolerant maize; production by inserting the cry1Ab gene from Bacillus thuringiensis subspecies kurstaki, and the phosphinothricin N-acetyltransferase (PAT) gene from S. viriochromogene p.</td><td>Zea mays L. (maize)</td>
<td>AND- 132</td><td>BT11 x MIR604</td><td>Syngenta Seeds, Inc.</td><td>Corn with a combination insect resistance and herbicide tolerance; production by traditional crossing of parental lines BT11 (label valid only for OECD: SYN-BT011-1) and MIR604 (label valid for OECD only: SYN-IR605-5). Grapefruit resistance piglet and tolerance to</td><td>Zea mays L. (maize)</td>
<td></td><td></td><td></td><td>the herbicide glufosinate ammonium (Liberty) is derived from BT11, which contains the cry1Ab gene from Bacillus thuringiensis subspecies kurstaki, and the phosphinothricin N-acetyltransferase (PAT) gene from S. viridochromogenes. The corn rootworm resistance is derived from MIR604, which contains the mcry3A gene from Bacillus thuringiensis.</td><td></td>
<td>AND- 133</td><td>BT11 x MIR604 x GA21</td><td>Syngenta Seeds, Inc.</td><td>Corn with a combination insect resistance and herbicide tolerance; production by traditional crossing of parental lines BT11 (label valid only for OECD: SYN-BT011-1), MIR604 (label valid only for OECD: SYN-IR605-5) and GA21 (label valid only for OECD: MON- 00021-9). Grapefruit resistance piglet and tolerance to the herbicide glufosinate ammonium (Liberty) is derived from BT11, which contains the cry1Ab gene from Bacillus thuringiensis subspecies kurstaki, and the N-acetyltransferase gene phosphinothricin (PAT) from S. viridochromogenes. The resistance to the corn rootworm comes from MIR604, which contains the mcry3A gene from Bacillus thuringiensis. The glyphosate herbicide tolerance is derived from GA21, which contains a modified maize EPSPS gene.</td><td>Zea mays L. (maize)</td>
<td>AND- 134</td><td>CBH-351</td><td>Aventis CropScience</td><td>Maize with insect resistance and tolerance to the herbicide glufosinate ammonium; development by introducing a dk gene for a protein</td><td>Zea mays L. (maize)</td>
<td></td><td></td><td></td><td>Cry9C from Bacillus thuringiensis subspecies tolworthi and the gene for phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus.</td><td></td>
<td>AND- 135</td><td>DAS-06275-8</td><td>DOW AgroSciences LLC</td><td>Maize variety with lepidopteran resistance and tolerance to the herbicide glufosinate ammonium; development by introducing the cry1F gene from Bacillus thuringiensis variant aizawai i phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus.</td><td>Zea mays L. (maize)</td>
<td>AND- 136</td><td>DAS-59122-7</td><td>DOW AgroSciences LLC and Pioneer HiBred International Inc.</td><td>Maize with resistance to the Colorado beetle; production by introducing the cry34Ab1 gene and the cry35Ab1 gene from Bacillus thuringiensis strain PS149B1. The PAT gene from Streptomyces viridochromogenes was introduced as a selectable marker; US 2006-070139</td><td>Zea mays L. (maize)</td>
<td>AND- 137</td><td>DAS-59122-7 x NK603</td><td>DOW AgroSciences LLC and Pioneer HiBred International Inc.</td><td>Corn with a combination insect resistance and herbicide tolerance; production by traditional crossing of parental lines DAS-59122-7 (OECD designation only: DAS-59122-7) with NK603 (OECD designation only: MON-006036). The resistance to the corn rootworm comes from the DAS-59122-7 line which contains the cry34Ab1 and cry35Ab1 gene from Bacillus thuringiensis strain PS149B1. The tolerance to the glyphosate herbicide is from NK603.</td><td>Zea mays L. (maize)</td>
<td>AND- 138</td><td>DAS-59122-7 x TC1507 x NK603</td><td>DOW AgroSciences LLC and Pioneer HiBred International Inc.</td><td>Corn with a combination insect resistance and herbicide tolerance; production by traditional crossing of parental lines DAS-59122-7 (OECD label only: DAS-59122-7) and TC1507 (OECD only label: DAS-015071) with NK603 (OECD only label: MON-00603-6). The resistance to the corn rootworm comes from the DAS-59122-7 line which contains the cry34Ab1 and cry35Ab1 gene from Bacillus thuringiensis strain PS149B1. Lepidopteran pest resistance and tolerance to the herbicide glufosinate ammonium are derived from TC1507. The glyphosate herbicide tolerance is derived from NK603.</td><td>Zea mays L. (maize)</td>
<td>AND- 139</td><td>DAS-01507-1 x MON- 00603-6</td><td>DOW AgroSciences LLC</td><td>Corn with a combination insect resistance and herbicide tolerance; production by traditional crossing of parental lines 1507 (OECD code: DAS-01507-1) and NK603, (OECD code: MON00603-6).</td><td>Zea mays L. (maize)</td>
<td>AND- 140</td><td>DBT418</td><td>Dekalb Genetics Corporation</td><td>Maize with insect resistance and tolerance to the herbicide glufosinate ammonium; development by inserting genes for the Cry1AC protein from Bacillus thuringiensis subspecies kurstaki i phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus.</td><td>Zea mays L. (maize)</td>
<td>AND-</td><td>DK404SR</td><td>BASF Inc.</td><td>Somaclonal variants of the</td><td>Zea mays L.</td>
<td> 141</td><td></td><td></td><td>modified acetyl-CoA- carboxylase (ACCase) selected by growing embryos on the medium enriched with sethoxydime.</td><td>(maize)</td>
<td>AND- 142</td><td>DP-098140-6</td><td></td><td>tolerance to glyphosate / ALS inhibitors; WO 2008/112019</td><td>Zea mays L. (maize)</td>
<td>AND- 143</td><td>D-098140-6 (event 98140)</td><td>Pioneer Hi-Bred International Inc.</td><td>Corn line 98140 has been genetically engineered to express the protein GAT4621 (glyphosate acetyltransferase) and the ZM-HRA protein (a modified version of maize synthase acetolactate). Protein GAT4621, which is encoded by the gat4621 gene, confers herbicide tolerance containing glyphosate by acetylating glyphosate, making it non-phytotoxic. The ZM-HRA protein, which is encoded by the zm-hra gene, confers tolerance to the herbicide class of ALS inhibitors.</td><td>Zea mays L. (maize)</td>
<td>AND- 144</td><td>event 3272</td><td>Syngenta Seeds, Inc.</td><td>A maize line that expresses the amy797E heat-stable alphaamylase gene for ethanol production by a dry milling method. The E. coli phosphomannose isomerase gene was used as a marker selective.</td><td>Zea mays L. (maize)</td>
<td>AND- 145</td><td>EXP1910IT</td><td>Syngenta Seeds, Inc. (formerly Zeneca Seeds)</td><td>Herbicide tolerance imidazolinone imazethapyr was caused by chemical mutagenesis of the enzyme acetolactate synthase (ALS) with ethyl methanesulfonate (EMS).</td><td>Zea mays L. (maize)</td>
<td>AND- 146</td><td>FI117</td><td></td><td>glyphosate tolerance; US 6,040,497</td><td>Zea mays L. (maize)</td>
<td>AND- 147</td><td>GA21</td><td>Monsanto Company</td><td>Modified 5-enolipyruvi ano-shikim-3-phosphate synthase (EPSPS), an enzyme that participates in the shikimate biosynthetic pathway to form aromatic amino acids, was induced by gene gun fire.</td><td>Zea mays L. (maize)</td>
<td>AND- 148</td><td>GAT-ZM1</td><td></td><td>tolerance to glufosinates; WO 01/51654</td><td>Zea mays L. (maize)</td>
<td>AND- 149</td><td>GG25</td><td></td><td>glyphosate tolerance; US 6,040,497</td><td>Zea mays L. (maize)</td>
<td>AND- 150</td><td>GJ11</td><td></td><td>glyphosate tolerance; US 6,040,497</td><td>Zea mays L. (maize)</td>
<td>AND- 151</td><td>IT</td><td>Pioneer Hi-Bred International Inc.</td><td>Herbicide tolerance imidazolinone imazethapyr was obtained by in-vitro selection of variants somaclonal.</td><td>Zea mays L. (maize)</td>
<td>AND- 152</td><td>LY038</td><td>Monsanto Company</td><td>Amino acid composition changed, especially increased lysine content, by introduction of the cordapA gene from Corynebacterium glutamicum, which encodes the enzyme dihydrodipicolinate synthase (cDHDPS); US 7,157,281</td><td>Zea mays L. (maize)</td>
<td>AND- 153</td><td>MIR 162</td><td></td><td>insect resistance; WO 2007142840</td><td>Zea mays L. (maize)</td>
<td>AND- 154</td><td>MIR604</td><td>Syngenta Seeds, Inc.</td><td>Corn root resistant maize was produced by transformation with a modified cry3A gene. The E. coli phosphomannose isomerase gene was used as a marker</td><td>Zea mays L. (maize)</td>
<td></td><td></td><td></td><td>selective. (Cry3a055); EP 1 737 290</td><td></td>
<td>AND- 155</td><td>MIR604 x GA21</td><td>Syngenta Seeds, Inc.</td><td>Corn with a combination insect resistance and herbicide tolerance; production by traditional crossing of parental lines MIR604 (label valid only for OECD: SYN-IR605-5) and GA21 (label valid only for OECD: MON- 00021-9). The resistance to the corn rootworm comes from MIR604, which contains the mcry3A gene from Bacillus thuringiensis. Tolerance relative to the glyphosate herbicide is derived from GA21.</td><td>Zea mays L. (maize)</td>
<td>AND- 156</td><td>MON80100</td><td>Monsanto Company</td><td>Insect resistant maize; production by insertion of the cry1Ab gene from Bacillus thuringiensis subspecies kurstaki. Genetic modification confers resistance to invasion by the European corn borer.</td><td>Zea mays L. (maize)</td>
<td>AND- 157</td><td>MON802</td><td>Monsanto Company</td><td>Maize with insect resistance and tolerance to the herbicide glyphosate; production by inserting the gene for the CryIAb protein from Bacillus thuringiensis and the enzyme 5enolipyrvyloshikimato-3-phosphate synthase (EPSPS) from A.tumefaciens strain CP4.</td><td>Zea mays L. (maize)</td>
<td>AND- 158</td><td>MON809</td><td>Pioneer Hi-Bred International Inc.</td><td>Grapefruit resistance piglet (Ostrinia nubilalis) by introducing the synthetic gene cry1Ab. Glyphosate resistance by introducing a bacterial version of the plant enzyme, synthase 5-</td><td>Zea mays L. (maize)</td>
<td></td><td></td><td></td><td>enolipyruvic ano-shikimate-3-phosphate (EPSPS).</td><td></td>
<td>AND- 159</td><td>MON810</td><td>Monsanto Company</td><td>Insect resistant maize; production by introducing a truncated version of the cry1Ab gene from Bacillus thuringiensis subspecies kurstaki HD-1. Genetic modification confers resistance to invasion by the European bumblebee piglet; US 2004-180373</td><td>Zea mays L. (maize)</td>
<td>AND- 160</td><td>MON810 x MON88017</td><td>Monsanto Company</td><td>Corn with a combination insect resistance and glyphosate tolerance; production by traditional cotton crossing of parent lines MON810 (OECD code: MON- 00810-6) and MON88017, (OECD reference number: MON-880173). The resistance to the European corn borer comes from a truncated form of the cryIAb gene from Bacillus thuringiensis subspecies kurstaki HD-1 which is found in MON810. The resistance to the corn rootworm comes from the cry3Bb1 gene of Bacillus thuringiensis subspecies kumamotoensis, strain EG4691 which is found in MON88017. Glyphosate tolerance is derived from the gene for 5enolipyrvyloshikimato-3-phosphate synthase (EPSPS) from Agrobacterium tumefaciens strain CP4 which is present in MON88017.</td><td>Zea mays L. (maize)</td>
<td>AND- 161</td><td>MON832</td><td>Monsanto Company</td><td>Introduction of glyphosate oxidase (GOX) and modified 5-enolipyruvylshikimate-3-phosphate synthase (EPSPS), an enzyme that is involved in the pathway</td><td>Zea mays L. (maize)</td>
<td></td><td></td><td></td><td>shikimate biosynthesis to create aromatic amino acids was induced by gene gun fire.</td><td></td>
<td>AND- 162</td><td>MON863</td><td>Monsanto Company</td><td>Corn with resistance to the Colorado beetle: Production by insertion of the cry3Bb1 gene from Bacillus thuringiensis subspecies kumamotoensis.</td><td>Zea mays L. (maize)</td>
<td>AND- 163</td><td>MON87460</td><td></td><td>Drought tolerant; water shortage tolerance; WO 2009/111263</td><td>Zea mays L. (maize)</td>
<td>AND- 164</td><td>MON88017</td><td>Monsanto Company</td><td>Corn with resistance to the Colorado beetle: Production by insertion of the cry3Bb1 gene from Bacillus thuringiensis subspecies Kumamotoensis, strain EG4691. Glyphosate tolerance is made by introducing a gene for synthase 5- enolipyrvyloshikimato-3-phosphate (EPSPS) with Agrobacterium tumefaciens strain CP4: WO 2005059103</td><td>Zea mays L. (maize)</td>
<td>AND- 165</td><td>MON89034</td><td>Monsanto Company</td><td>An event in maize that expresses two different insecticidal proteins from Bacillus thuringiensis, which confers resistance to various lepidopteran pests, insect resistance (Lipidoptera -Cry1A.105Cry2Ab); WO 2007140256</td><td>Zea mays L. (maize)</td>
<td>AND- 166</td><td>MON89034 x MON88017</td><td>Monsanto Company</td><td>Corn with a combination insect resistance and glyphosate tolerance; production by traditional crossing of parent lines MON89034 (OECD reference number: MON-89 034-3) and MON88017 (reference number</td><td>Zea mays L. (maize)</td>
<td></td><td></td><td></td><td>OECD: MON-88017-3). The resistance of lepiopterans is derived from two cry genes that are found in MON89043. The corn rootworm resistance is derived from a single cry gene and glyphosate tolerance is derived from a single gene for 5enolipyrvylshikimato-3phosphate synthase (EPSPS) from Agrobacterium tumefaciens, which is found in MON88017.</td><td></td>
<td>AND- 167</td><td>MON-006036 x MON00810-6</td><td>Monsanto Company</td><td>Maize hybrid with a combination of insect resistance and herbicide tolerance; production by traditional crossing of parental lines NK603 (OECD code: MON-00603-6) i MON810, (OECD code: MON-00810-6).</td><td>Zea mays L. (maize)</td>
<td>AND- 168</td><td>MON-00810- 6 x LY038</td><td>Monsanto Company</td><td>Corn with a combination insect resistance and increased lysine content, produced by traditional crossing of the parent lines MON810 (OECD code: MON-00810-6) and LY038 (OECD code: REN-000383).</td><td>Zea mays L. (maize)</td>
<td>AND- 169</td><td>MON-00863-5 x MON- 00603-6</td><td>Monsanto Company</td><td>Maize hybrid with a combination of insect resistance and herbicide tolerance; production by traditional crossing of MON863 parental lines (OECD code: MON00863-5) and NK603, (OECD code: MON-00603-6).</td><td>Zea mays L. (maize)</td>
<td>AND- 170</td><td>MON-00863-5 x MON-</td><td>Monsanto Company</td><td>Maize hybrid with a combination of insect resistance; production</td><td>Zea mays L. (maize)</td>
<td></td><td> 00810-6</td><td></td><td>by traditional crossing of MON863 parental lines (OECD code: MON00863-5) and MON810, (OECD code: MON-00810-6).</td><td></td>
<td>AND- 171</td><td>MON-00863-5 x MON- 00810-6 x MON-006036</td><td>Monsanto Company</td><td>Maize hybrid with a combination of insect resistance and herbicide tolerance; production by traditional crossing containing the combination of hybrids MON-00863-5 x MON-00810-6 and NK603 (OECD code: MON-00603-6).</td><td>Zea mays L. (maize)</td>
<td>AND- 172</td><td>MON-000219 x MON00810-6</td><td>Monsanto Company</td><td>Hybrid corn with a combination of insect resistance and herbicide tolerance; Derivation by traditional crossing of the parent lines GA21 (OECD code: MON00021-9) and MON810 (OECD code: MON-00810-6).</td><td>Zea mays L. (maize)</td>
<td>AND- 173</td><td>MS3</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Male sterility by expression of the bacillus amyloliquefaciens barnase ribonuclease gene; PPT resistance was achieved by PPT acetyltransferase (PAT).</td><td>Zea mays L. (maize)</td>
<td>AND- 174</td><td>MS6</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Male sterility by expression of the bacillus amyloliquefaciens barnase ribonuclease gene; PPT resistance was achieved by PPT acetyltransferase (PAT).</td><td>Zea mays L. (maize)</td>
<td>AND- 175</td><td>NK603</td><td>Monsanto Company</td><td>Introduction of the modified 5-enolpyruvate synthase shikimate-3-phosphate (EPSPS), an enzyme that is involved in the shikimate biosynthetic pathway to create aromatic amino acids induced by gun fire</td><td>Zea mays L. (maize)</td>
<td></td><td></td><td></td><td>gene.</td><td></td>
<td>AND- 176</td><td>PV-ZMGT32 (NK603)</td><td></td><td>glyphosate tolerance; US 2007056056</td><td>Zea mays L. (maize)</td>
<td>AND- 177</td><td>PVZMGT32 (nk60 3)</td><td></td><td>glyphosate tolerance; US 2007292854</td><td>Zea mays L. (maize)</td>
<td>AND- 178</td><td>PV-ZMIR13 (MON863)</td><td></td><td>insect resistance (Cry3Bb); US 2006-095986</td><td>Zea mays L. (maize)</td>
<td>AND- 179</td><td>SYN-BT011-1 x MON- 00021-9</td><td>Syngenta Seeds, Inc.</td><td>Corn with a combination insect resistance and herbicide tolerance; production by traditional crossing of parental lines BT11 (only valid for OECD: SYN-BT011-1) and GA21 (label valid for OECD only: MON-00021-9).</td><td>Zea mays L. (maize)</td>
<td>AND- 180</td><td>T14, T25</td><td>Bayer CropScience (Aventis CropScience (AgrEvo))</td><td>Maize tolerant to the herbicide glufosinate; production by introducing a modified gene for phosphinothricin nacetyltransferase (PAT) from aerobic Actinomycetene Streptomyces viridochromogenes.</td><td>Zea mays L. (maize)</td>
<td>AND- 181</td><td>TC1507</td><td>Mycogen (c / o Dow AgroSciences); Pioneer (c / o Dupont)</td><td>Maize with insect resistance and tolerance to the herbicide glufosinate ammonium; production by introducing the cry1F gene from Bacillus thuringiensis variant aizawai and the N- gene phosphinothricin acetyltransferase from Streptomyces viriochromogene p.</td><td>Zea mays L. (maize)</td>
<td>AND- 182</td><td>TC1507 x DAS-59122-7</td><td>DOW AgroSciences LLC and Pioneer HiBred International</td><td>Corn with a combination insect resistance and herbicide tolerance; production by traditional crossing lines</td><td>Zea mays L. (maize)</td>
<td rowspan="2"></td><td rowspan="2"></td><td rowspan="2">Inc.</td><td>TC 1507 (OECD label only: DAS-01507-1) with DAS-59122-7 (OECD only label: DAS-59122-7). Lepidoptera insect resistance is derived from TC 1507 due to the presence of the cry1F gene from Bacillus thuringiensis cultivar aizawai. The resistance to the corn rootworm comes from the DAS-59122-7 line which contains the cry34Abl gene and the cry35Abl gene from Bacillus</td><td rowspan="2"></td>
<td>thuringiensis strain PS149B1. The tolerance to the herbicide glufosinate ammonium is derived from TC 1507 from the gene for phosphinothricin N-acetyltransferase from Streptomyces viriochromogene s.</td>
<td>AND- 183</td><td>ΥΙΡ1034</td><td></td><td>insect resistance; WO 03/052073</td><td>Zea mays L. (maize)</td>
In a preferred embodiment of the invention, the plants B1 are treated to B-129 in Table B completely or partially, or the propagation material of these plants is treated or brought into contact with the active ingredient combinations according to the invention either separately or in the form of compositions which contain a combination active substances.
Table B
Non-exhaustive list of transgenic plants for carrying out the invention from the United States Department of Agriculture (USDA) APHIS database. The data bank is at:
http://www.aphis.usda.gov/animal welfare / efoia / index.shtml.
Abbreviations used in this table:
cucumber mosaic virus CMV, Colorado potato beetle CPB, potato leaf roll virus PLRV, papaya ringspot virus PRSV, potato virus Y PVY, watermelon mosaic virus WMV2, courgette yellow mosaic virus 2 ”ZYMV
<td>No</td><td>Proposal</td><td>Extension number</td><td>Institution</td><td>Plant</td><td>Transformational event</td><td>final provision EA</td>
<td></td><td></td><td>request ***</td><td></td><td></td><td>or line</td><td>& designation</td>
<td>B-1</td><td>10-070- 01p</td><td></td><td>Virginia Tech</td><td>peanut</td><td>Resistant to rot caused by Sclerotinia</td><td>N70, P39 und W171</td>
<td>B-2</td><td>09-349- 01p</td><td></td><td>Dow AgroSciences</td><td>Soybeans</td><td>tolerance to 2,4-D and glufosinates</td><td>DAS-68416-4</td>
<td>B-3</td><td>09-328- 01p</td><td></td><td>Bayer Crop Science</td><td>Soybeans</td><td>tolerance to glyphosate and isoxaflutole</td><td>FG72</td>
<td>B-4</td><td>09-233- 01p</td><td></td><td>Dow</td><td>maize</td><td>tolerance to 2,4-D and inhibitors ACCazy</td><td>DAS-40278-9</td>
<td>B-5</td><td>09-201- 01p</td><td></td><td>Monsanto</td><td>Soybeans</td><td>improved fatty acid profile</td><td>MON-87705- 6</td>
<td>B-6</td><td>09-183- 01p</td><td></td><td>Monsanto</td><td>Soybeans</td><td>Preparation of stearidonic acid</td><td>MON-87769</td>
<td>B-7</td><td>09-082- 01p</td><td></td><td>Monsanto</td><td>Soybeans</td><td>Resistance to Lepidoptera</td><td>MON 87701</td>
<td>B-8</td><td>09-063- 01p</td><td></td><td>Stine Seed</td><td>maize</td><td>tolerance to glyphosate</td><td>HCEM485</td>
<td>B-9</td><td>09-055- 01p</td><td></td><td>Monsanto</td><td>maize</td><td>Drought tolerant</td><td>MON 87460</td>
<td>Β- ΙΟ</td><td>09-015- 01p</td><td></td><td>BASF Plant Science, LLC</td><td>Soybeans</td><td>tolerance to imidazolinone</td><td>BPS-CV127-9 Soybeans</td>
<td>B- 11</td><td>08-366- 01p</td><td></td><td>ArborGen</td><td>Eucalyptus</td><td>frost tolerance, altered fertility</td><td>ARB-FTE1-08</td>
<td>B- 12</td><td>08-340- 01p</td><td></td><td>Bayer</td><td>Cotton</td><td>tolerance to glufosinates, resistance to insects</td><td>T30440XGHB119</td>
<td>B- 13</td><td>08-338- 01p</td><td></td><td>Pioneer</td><td>maize</td><td>male sterility, restored fertility, visual characteristics</td><td>DP-32138-1</td>
<td>B- 14</td><td>08-315- 01p</td><td></td><td>Florigene</td><td>rose</td><td>Changed color of flowers</td><td>IFD-52401-4 i IFD-52901-9</td>
<td>B- 15</td><td>07-108- 01p</td><td></td><td>Syngenta</td><td>Cotton</td><td>Resistance to Lepidoptera</td><td>COT67B</td>
<td>B16 B- 17</td><td>06-354- 01p</td><td></td><td>Pioneer</td><td>Soybeans</td><td>Higher oleic acid content</td><td>D-305423-1</td>
<td>B18 B- 19</td><td>05-280- 01p</td><td></td><td>Syngenta</td><td>maize</td><td>heat resistant alpha amylase</td><td> 3272</td>
<td>B20 B- 21 B22 B- 23</td><td>04-110- 01p</td><td></td><td>Monsanto & Forage Genetics</td><td>Alfalfa</td><td>tolerance to glyphosate</td><td>J101, J163</td>
<td>B24 B25 B26 B27</td><td>03-104- 01p</td><td></td><td>Monsanto & Scotts</td><td>white cream</td><td>tolerance to glyphosate</td><td>ASR368</td>
<td>B- 28 B- 29</td><td></td><td></td><td></td><td></td><td></td><td></td>
<td>B30 B31</td><td>07-253- 01p</td><td></td><td>Syngenta</td><td>maize</td><td>Resistance to Lepidoptera</td><td>MIR-162 maize</td>
<td>B32 B- 33</td><td>07-152- 01p</td><td></td><td>Pioneer</td><td>maize</td><td>tolerance to glyphosates & imidazolinone</td><td>DP-098140-6</td>
<td>B34 B35</td><td>04-337- 01p</td><td></td><td>University of Florida</td><td>papaya</td><td>resistance against papaya ringspot virus</td><td>X17-2</td>
<td>B- 36 B- 37</td><td>06-332- 01p</td><td></td><td>Bayer CropScience</td><td>Cotton</td><td>tolerance to glyphosate</td><td>GHB614</td>
<td>B38 B- 39</td><td>06-298- 01p</td><td></td><td>Monsanto</td><td>maize</td><td>Resistance to European cornflower</td><td>MON 89034</td>
<td>B- 40 B- 41</td><td>06-271- 01p</td><td></td><td>Pioneer</td><td>Soybeans</td><td>tolerance to glyphosates & acetylate lactate synthase</td><td>356043 (DP356043-5)</td>
<td>B- 42 B-</td><td>06-234- 01p</td><td>98-329-01p</td><td>Bayer CropScience</td><td>rice</td><td>tolerance to phosphinothricin</td><td>LLRICE601</td>
<td> 43</td><td></td><td></td><td></td><td></td><td></td><td></td>
<td>B- 44 B- 45</td><td>06-178- 01p</td><td></td><td>Monsanto</td><td>soybeans</td><td>tolerance to glyphosate</td><td>MON 89788</td>
<td>B46 B47 B48</td><td>04-362- 01p</td><td></td><td>Syngenta</td><td>maize</td><td>protection against the corn rootworm</td><td>MIR604</td>
<td>B49 B50</td><td>04-264- 01p</td><td></td><td>ARS</td><td>plum trees</td><td>resistance against plum pox virus</td><td>C5</td>
<td>B51 B52</td><td>04-229- 01p</td><td></td><td>Monsanto</td><td>maize</td><td>high lysine content</td><td>LY038</td>
<td>B53 B54</td><td>04-125- 01p</td><td></td><td>Monsanto</td><td>maize</td><td>resistance to the corn Colorado beetle</td><td> 88017</td>
<td>B55 B56 B57</td><td>04-086- 01p</td><td></td><td>Monsanto</td><td>Cotton</td><td>tolerance to glyphosate</td><td>MON 88913</td>
<td>B- 58</td><td>03-353- 01p</td><td></td><td>Dow</td><td>maize</td><td>resistance to Colorado beetle</td><td> 59122</td>
<td>B- 59</td><td></td><td></td><td></td><td></td><td>maize</td><td></td>
<td>B60 B61</td><td>03-323- 01p</td><td></td><td>Monsanto</td><td>White beet</td><td>tolerance to glyphosate</td><td>H7-1</td>
<td>B62 B63</td><td>03-181- 01p</td><td>00-136-01p</td><td>Dow</td><td>maize</td><td>resistance to Lepidoptera & tolerance to phosphinothricin</td><td>TC-6275</td>
<td>B64 B65</td><td>03-155- 01p</td><td></td><td>Syngenta</td><td>Cotton</td><td>resistance to Lepidoptera</td><td>COT 102</td>
<td>B66 B67</td><td>03-036- 01p</td><td></td><td>Mycogen / Dow</td><td>Cotton</td><td>Resistance to Lepidoptera</td><td> 281-24-236</td>
<td>B68 B- 69</td><td>03-036- 02p</td><td></td><td>Mycogen / Dow</td><td>Cotton</td><td>Resistance to Lepidoptera</td><td> 3006-210-23</td>
<td>B- 70</td><td>02-042- 01p</td><td></td><td>Aventis</td><td>Cotton</td><td>tolerance to phosphinothricin</td><td>LLCotton25</td>
<td>B- 71</td><td>01-324- 01p</td><td>98-216-01p</td><td>Monsanto</td><td>rape</td><td>tolerance to glyphosate</td><td>RT200</td>
<td>B- 72</td><td>01-206- 01p</td><td>98-278-01p</td><td>Aventis</td><td>rape</td><td>tolerance to phosphinothricin & pollination control</td><td>MS1 & RF1 / RF2</td>
<td>B- 73</td><td>01-206- 02p</td><td>97-205-01p</td><td>Aventis</td><td>rape</td><td>tolerance to phosphinothricin</td><td>Topas 19/2</td>
<td>B- 74</td><td>01-137- 01p</td><td></td><td>Monsanto</td><td>maize</td><td>Resistance to the corn Colorado beetle</td><td>MON 863</td>
<td>B- 75</td><td>01-121- 01p</td><td></td><td>vector</td><td>tobacco</td><td>lowered nicotine content</td><td>vector 21-41</td>
<td>B- 76</td><td>00-342- 01p</td><td></td><td>Monsanto</td><td>Cotton</td><td>Resistance to Lepidoptera</td><td>Cotton event 15985</td>
<td>B- 77</td><td>00-136- 01p</td><td></td><td>Mycogen c / o Dow & Pioneer</td><td>maize</td><td>Resistance to Lepidoptera & tolerance to phosphinothricin</td><td>Line 1507</td>
<td>B- 78</td><td>00-011- 01p</td><td>97-099-01p</td><td>Monsanto</td><td>maize</td><td>tolerance to glyphosate</td><td>NK603</td>
<td>B- 79</td><td>99-173- 01p</td><td>97-204-01p</td><td>Monsanto</td><td>potato</td><td>resistance to PLRV & CPB</td><td>RBMT22-82</td>
<td>B- 80</td><td>98-349- 01p</td><td>95-228-01p</td><td>AgrEvo</td><td>maize</td><td>tolerance to phosphinothricin and male sterility</td><td>MS6</td>
<td>B- 81</td><td>98-335- 01p</td><td></td><td>AT. Saskatchewan</td><td>flax</td><td>Tolerance for residual sulfonylurea herbicide in soil</td><td>CDC Triffid</td>
<td>B- 82</td><td>98-329- 01p</td><td></td><td>AgrEvo</td><td>rice</td><td>tolerance to phosphinothricin</td><td>LLRICE06, LLRICE62</td>
<td>B- 83</td><td>98-278- 01p</td><td></td><td>AgrEvo</td><td>rape</td><td>tolerance to phosphinothricin & pollination control</td><td>MS8 & RF3</td>
<td>B- 84</td><td>98-238- 01p</td><td></td><td>AgrEvo</td><td>Soybeans</td><td>tolerance to phosphinothricin</td><td>GU262</td>
<td>B- 85</td><td>98-216- 01p</td><td></td><td>Monsanto</td><td>rape</td><td>tolerance to glyphosate</td><td>RT73</td>
<td>B- 86</td><td>98-173- 01p</td><td></td><td>Novartis Seeds & Monsanto</td><td>Beetroot</td><td>tolerance to glyphosate</td><td>GTSB77</td>
<td>B- 87</td><td>98-014- 01p</td><td>96-068-01p</td><td>AgrEvo</td><td>Soybeans</td><td>tolerance to phosphinothricin</td><td>A5547-127</td>
<td>B- 88</td><td>97-342- 01p</td><td></td><td>Pioneer</td><td>maize</td><td>male sterility & tolerance to phosphinothricin</td><td> 676,678,680</td>
<td>B- 89</td><td>97-339- 01p</td><td></td><td>Monsanto</td><td>potato</td><td>resistance to CPB & PVY</td><td>RBMT15-101, SEMT15-02, SEMT15-15</td>
<td>B- 90</td><td>97-336- 01p</td><td></td><td>AgrEvo</td><td>Beetroot</td><td>tolerance to phosphinothricin</td><td>T-120-7</td>
<td>B- 91</td><td>97-287- 01p</td><td></td><td>Monsanto</td><td>Tomato</td><td>Resistance to Lepidoptera</td><td> 5345</td>
<td>B- 92</td><td>97-265- 01p</td><td></td><td>AgrEvo</td><td>maize</td><td>tolerance to phosphinothricin & resistance to Lepidoptera</td><td>CBH-351</td>
<td>B- 93</td><td>97-205- 01p</td><td></td><td>AgrEvo</td><td>rape</td><td>tolerance to phosphinothricin</td><td>T45</td>
<td>B- 94</td><td>97-204- 01p</td><td></td><td>Monsanto</td><td>potato</td><td>resistance to CPB & PLRV</td><td>RBMT21-129 & RBMT21- 350</td>
<td>B- 95</td><td>97-148- 01p</td><td></td><td>Bejo</td><td>Cichorium intybus</td><td>male sterility</td><td>RM3-3, RM3- 4, RM3-6</td>
<td>B- 96</td><td>97-099- 01p</td><td></td><td>Monsanto</td><td>maize</td><td>tolerance to glyphosate</td><td>GA21</td>
<td>B- 97</td><td>97-013- 01p</td><td></td><td>Calgene</td><td>Cotton</td><td>tolerance to bromoxynil & resistance to Lepidoptera</td><td>events 31807 & 31808</td>
<td>B-</td><td> 97-008-</td><td></td><td>Du Pont</td><td>Soybeans</td><td>changed profile</td><td>G94-1, G94-</td>
<td> 98</td><td>01p</td><td></td><td></td><td></td><td>oil</td><td>19, G-168</td>
<td>B- 99</td><td>96-317- 01p</td><td></td><td>Monsanto</td><td>maize</td><td>tolerance to glyphosate & resistance to ECB</td><td>MON802</td>
<td>B- 100</td><td>96-291- 01p</td><td></td><td>DeKalb</td><td>maize</td><td>Resistance to European cornflower</td><td>DBT418</td>
<td>Β- 101</td><td>96-248- 01p</td><td>92-196-01p</td><td>Calgene</td><td>Tomato</td><td>changed fruit ripening</td><td>1 additional FLAVRSAVR line</td>
<td>B- 102</td><td>96-068- 01p</td><td></td><td>AgrEvo</td><td>Soybeans</td><td>tolerance to phosphinothricin</td><td>W62, W98, A2704- 12, A2704-21, A5547-35</td>
<td>B- 103</td><td>96-051- 01p</td><td></td><td>Cornell U</td><td>papaya</td><td>Resistance to PRSV</td><td> 55-1,63-1</td>
<td>B- 104</td><td>96-017- 01p</td><td>95-093-01p</td><td>Monsanto</td><td>maize</td><td>Resistance to European cornflower</td><td>MON809 & MON810</td>
<td>B- 105</td><td>95-352- 01p</td><td></td><td>Asgrov</td><td>Summer pumpkin</td><td>resistance to CMV, ZYMV, WMV2</td><td>THU-3</td>
<td>B- 106</td><td>95-338- 01p</td><td></td><td>Monsanto</td><td>potato</td><td>resistance to CPB</td><td>SBT02-5 & -7, ATBT04-6 & 27, - 30, -31, 36</td>
<td>B- 107</td><td>95-324- 01p</td><td></td><td>Agritope</td><td>Tomato</td><td>altered fruit ripening</td><td>35 1 N.</td>
<td>B- 108</td><td>95-256- 01p</td><td></td><td>Du Pont</td><td>Cotton</td><td>resistance to sulfonylureas</td><td>19-51a</td>
<td>B- 109</td><td>95-228- 01p</td><td></td><td>Plant Genetic Systems</td><td>maize</td><td>male sterile</td><td>MS3</td>
<td>B-</td><td> 95-195-</td><td></td><td>Northrup King</td><td>maize</td><td>Resistance to the fingerstick</td><td>Bt11</td>
<td> 110</td><td>01p</td><td></td><td></td><td></td><td>piglet</td><td></td>
<td>B- 111</td><td>95-179- 01p</td><td>92-196-01p</td><td>Calgene</td><td>Tomato</td><td>altered fruit ripening</td><td>2 additional FLAVRSAVR lines</td>
<td>B- 112</td><td>95-145- 01p</td><td></td><td>DeKalb</td><td>maize</td><td>tolerance to phosphinothricin</td><td>B16</td>
<td>B- 113</td><td>95-093- 01p</td><td></td><td>Monsanto</td><td>maize</td><td>Resistance to Lepidoptera</td><td>MON 80100</td>
<td>B- 114</td><td>95-053- 01p</td><td></td><td>Monsanto</td><td>Tomato</td><td>changed fruit ripening</td><td> 8338</td>
<td>B- 115</td><td>95-045- 01p</td><td></td><td>Monsanto</td><td>Cotton</td><td>tolerance to glyphosate</td><td> 1445, 1698</td>
<td>B- 116</td><td>95-030- 01p</td><td>92-196-01p</td><td>Calgene</td><td>Tomato</td><td>changed fruit ripening</td><td>20 additional FLAVRSAVR lines</td>
<td>B- 117</td><td>94-357- 01p</td><td></td><td>AgrEvo</td><td>maize</td><td>tolerance to phosphinothricin</td><td>T14, T25</td>
<td>B- 118</td><td>94-319- 01p</td><td></td><td>Ciba Seeds</td><td>maize</td><td>Resistance to Lepidoptera</td><td>event 176</td>
<td>B- 119</td><td>94-308- 01p</td><td></td><td>Monsanto</td><td>Cotton</td><td>Resistance to Lepidoptera</td><td> 531, 757, 1076</td>
<td>B- 120</td><td>94-290- 01p</td><td></td><td>Zeneca & Petoseed</td><td>Tomato</td><td>Reduced polygalacturonase content in the fruit</td><td>B, Da, F</td>
<td>B- 121</td><td>94-257- 01p</td><td></td><td>Monsanto</td><td>potato</td><td>Resistance to Coleoptera</td><td>BT6, BT10, BT12, BT16, BT17, BT18, BT23</td>
<td>B- 122</td><td>94-230- 01p</td><td>92-196-01p</td><td>Calgene</td><td>Tomato</td><td>altered fruit ripening</td><td>9 additional lines</td>
<td></td><td></td><td></td><td></td><td></td><td></td><td>FLAVRSAVR</td>
<td>B- 123</td><td>94-228- 01p</td><td></td><td>DNA Plant Tech</td><td>Tomato</td><td>changed fruit ripening</td><td> 1345-4</td>
<td>B- 124</td><td>94-22701p</td><td>92-196-01p</td><td>Calgene</td><td>Tomato</td><td>changed fruit ripening</td><td>Line N73 1436-111</td>
<td>B- 125</td><td>94-090- 01p</td><td></td><td>Calgene</td><td>rape</td><td>changed oil profile</td><td>pCGN3828212 / 86- 18 & 23</td>
<td>B- 126</td><td>93-25801p</td><td></td><td>Monsanto</td><td>Soybeans</td><td>tolerance to glyphosate</td><td> 40-3-2</td>
<td>B- 127</td><td>93-196- 01p</td><td></td><td>Calgene</td><td>Cotton</td><td>Tolerance on bromoxynil</td><td>BXN</td>
<td>B- 128</td><td>92-20401p</td><td></td><td>Upjohn</td><td>Summer pumpkin</td><td>resistance to WMV2 & ZYMV</td><td>ZW-20</td>
<td>B- 129</td><td>92-196- 01p</td><td></td><td>Calgene</td><td>Tomato</td><td>altered fruit ripening</td><td>FLAVRSAVR</td>
[0100] In a preferred embodiment of the invention, plants that contain or express the transgenic event D-1 to D-48 of Table D of Table D are treated, or the propagation material of these plants is treated or brought into contact with combinations of substances. of the active substances according to the invention either alone or in the form of compositions which contain a combination of active substances.
Table D
<td colspan="5">A non-exhaustive list of transgenic events and features to which the invention may be applied, including patent applications.</td>
<td>No</td><td>Type of plant</td><td>Transgenic event</td><td>Feature</td><td>Patent mark</td>
<td>D- 1</td><td>maize</td><td>PV-ZMGT32 (NK603)</td><td>glyphosate tolerance</td><td>US 2007-056056</td>
<td>D- 2</td><td>maize</td><td>MIR604</td><td>insect resistance (Cry3a055)</td><td>EP-A 1 737 290</td>
<td>D- 3</td><td>maize</td><td>LY038</td><td>High in lysine</td><td>US 7,157,281</td>
<td>D- 4</td><td>maize</td><td> 3272</td><td>self-processing maize (alpha amylase)</td><td>US 2006-230473</td>
<td>D5</td><td>maize</td><td>PV-ZMIR13 (MON863)</td><td>insect resistance (Cry3Bb)</td><td>US 2006-095986</td>
<td>D- 6</td><td>maize</td><td>DAS-59122-7</td><td>insect resistance (Cry34Ab1 / Cry35Ab1)</td><td>US 2006-070139</td>
<td>D- 7</td><td>maize</td><td>TC1507</td><td>insect resistance (Cry1F)</td><td>US 7,435,807</td>
<td>D- 8</td><td>maize</td><td>MON810</td><td>insect resistance (Cry1Ab)</td><td>US 2004-180373</td>
<td>D- 9</td><td>maize</td><td>VIP1034</td><td>insect resistance</td><td>WO 03/052073</td>
<td>D- 10</td><td>maize</td><td>B16</td><td>resistance to glufosinates</td><td>US 2003-126634</td>
<td>D- 11</td><td>maize</td><td>GA21</td><td>glyphosate resistance</td><td>US 6,040,497</td>
<td>D- 12</td><td>maize</td><td>GG25</td><td>glyphosate resistance</td><td>US 6,040,497</td>
<td>D- 13</td><td>maize</td><td>GJ11</td><td>glyphosate resistance</td><td>US 6,040,497</td>
<td>D- 14</td><td>maize</td><td>FI117</td><td>glyphosate resistance</td><td>US 6,040,497</td>
<td>D- 15</td><td>maize</td><td>GAT-ZM1</td><td>tolerance to glufosinates</td><td>WO 01/51654</td>
<td>D- 16</td><td>maize</td><td>DP-098140-6</td><td>glyphosate tolerance / tolerance to ALS inhibitors</td><td>WO 2008/112019</td>
<td>D- 17</td><td>Wheat</td><td>event 1</td><td>Fusarium resistance (trichotekene-3-O-acetyl transferase)</td><td>CA 2561992</td>
<td>D- 18</td><td>White beet</td><td>T227-1</td><td>glyphosate tolerance</td><td>US 2004-117870</td>
<td>D-</td><td>Beetroot</td><td>H7-1</td><td>glyphosate tolerance</td><td>WO 2004-074492</td>
<td> 19</td><td>sugar</td><td></td><td></td><td></td>
<td>D- twenty</td><td>Soybeans</td><td>MON89788</td><td>glyphosate tolerance</td><td>US 2006-282915</td>
<td>D- 21</td><td>Soybeans</td><td>A2704-12</td><td>tolerance to glufosinates</td><td>WO 2006/108674</td>
<td>D- 22</td><td>Soybeans</td><td>A5547-35</td><td>tolerance to glufosinates</td><td>WO 2006/108675</td>
<td>D- 23</td><td>Soybeans</td><td>DP-305423-1</td><td>High oleic acid content / tolerance to ALS inhibitors</td><td>WO 2008/054747</td>
<td>D- 24</td><td>Rice</td><td>GAT-OS2</td><td>tolerance to glufosinates</td><td>WO 01/83818</td>
<td>D- 25</td><td>Rice</td><td>GAT-OS3</td><td>tolerance to glufosinates</td><td>US 2008-289060</td>
<td>D- 26</td><td>Rice</td><td>PE-7</td><td>insect resistance (Cry1Ac)</td><td>WO 2008/114282</td>
<td>D- 27</td><td>rape</td><td>MS-B2</td><td>male sterility</td><td>WO 01/31042</td>
<td>D- 28</td><td>rape</td><td>MS-BN1 / RF- BN1</td><td>male sterility / rebuild</td><td>WO 01/41558</td>
<td>D- 29</td><td>rape</td><td>RT73</td><td>glyphosate resistance</td><td>WO 02/36831</td>
<td>D- thirty</td><td>Cotton</td><td>CE43-67B</td><td>insect resistance (Cry1Ab)</td><td>WO 2006/128573</td>
<td>D- 31</td><td>Cotton</td><td>CE46-02A</td><td>insect resistance (Cry1Ab)</td><td>WO 2006/128572</td>
<td>D- 32</td><td>Cotton</td><td>CE44-69D</td><td>insect resistance (Cry1Ab)</td><td>WO 2006/128571</td>
<td>D- 33</td><td>Cotton</td><td>1143-14A</td><td>insect resistance (Cry1Ab)</td><td>WO 2006/128569</td>
<td>D- 34</td><td>Cotton</td><td>1143-51B</td><td>insect resistance (Cry1Ab)</td><td>WO 2006/128570</td>
<td>D- 35</td><td>Cotton</td><td>T342-142</td><td>insect resistance (Cry1Ab)</td><td>WO 2006/128568</td>
<td>D- 36</td><td>Cotton</td><td>event 3006210-23</td><td>insect resistance (Cry1Ac)</td><td>WO 2005/103266</td>
<td>D- 37</td><td>Cotton</td><td>PV-GHGT07 (1445)</td><td>glyphosate tolerance</td><td>US 2004-148666</td>
<td>D- 38</td><td>Cotton</td><td>MON88913</td><td>glyphosate tolerance</td><td>WO 2004/072235</td>
<td>D- 39</td><td>Cotton</td><td>EE-GH3</td><td>glyphosate tolerance</td><td>WO 2007/017186</td>
<td>D- 40</td><td>Cotton</td><td>T304-40</td><td>insect resistance (Cry1Ab)</td><td>WO2008 / 122406</td>
<td>D- 41</td><td>Cotton</td><td>Cot202</td><td>insect resistance (VIP3)</td><td>US 2007-067868</td>
<td>D- 42</td><td>Cotton</td><td>LLcotton25</td><td>resistance to glufosinates</td><td>WO 2007/017186</td>
<td>D- 43</td><td>Cotton</td><td>EE-GH5</td><td>insect resistance (Cry1Ab)</td><td>WO 2008/122406</td>
<td>D- 44</td><td>Cotton</td><td>event 28124-236</td><td>insect resistance (Cry1F)</td><td>WO 2005/103266</td>
<td>D- 45</td><td>Cotton</td><td>Cot102</td><td>insect resistance (Vip3A)</td><td>US 2006-130175</td>
<td>D- 46</td><td>Cotton</td><td>MON 15985</td><td>insect resistance (Cry1A / Cry2Ab)</td><td>US 2004-250317</td>
<td>D- 47</td><td>broom</td><td>Asr-368</td><td>glyphosate tolerance</td><td>US 2006-162007</td>
<td>D- 48</td><td>eggplant</td><td>EE-1</td><td>insect resistance (Cry1Ac)</td><td>WO 2007/091277</td>
[0101] In a preferred embodiment of the invention, plants are treated which contain or express the transgenic event E-1 to E-50 of Table E, or the propagation material of these plants is treated or brought into contact with the combinations. the active substances according to the invention either alone or in the form of compositions which contain a combination of active substances.
-75 Table E
<td colspan="6">Non-exhaustive list of transgenic events and traits and their trade names.</td>
<td>No</td><td>trade name</td><td>Plant</td><td>Undertaking</td><td>genetically modified properties</td><td>additional information</td>
<td>E-1</td><td>Roundup Ready®</td><td>Beta vulgaris (White beet)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td></td>
<td>E-2</td><td>InVigor®</td><td>Brassica napus (Argentine Canola oilseed rape)</td><td>Bayer CropScience</td><td>Canola oilseed rape has been genetically modified with the event below; 0 expression of a gene that confers tolerance to the herbicide ammonium glyphosinate; 0 introduction of a new hybrid breeding system for Canola oilseed rape that relies on genetically modified male sterility (MS) and restored fertility (RF) lines; 0 Antibiotic resistance gene expression</td><td></td>
<td>E-3</td><td>Liberty Link®</td><td>Brassica napus (Argentine Canola Rape)</td><td>B ayerCropScience</td><td>Phosphinothricin tolerance</td><td></td>
<td>E-4</td><td>Roundup Ready®</td><td>Brassica napus (Canola Rapeseed)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td></td>
<td>E-5</td><td>Clearfield®</td><td>(Canola rape)</td><td>BASF Corporation</td><td>non-GMO, imazamox tolerant</td><td></td>
<td>E-6</td><td>Optimum ™ GAT ™</td><td>Glycine max L. (soybeans)</td><td>Pioneer Hi-Bred International, Inc</td><td>Glyphosate and ALS herbicide tolerance</td><td></td>
<td>E-7</td><td>Roundup Ready®</td><td>Glycine max L. (soybeans)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td></td>
<td>E-8</td><td>Roundup RReady2Yiel <sup>TM</sup></td><td>Glycine max L. (soybeans)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td></td>
<td>E-9</td><td>STS®</td><td>Glycine max L. (soybeans)</td><td>DuPont</td><td>Tolerance to sulfonylureas</td><td></td>
<td>E-10</td><td>YIELD GARD®</td><td>Glycine max L. (soybeans)</td><td>Monsanto Company</td><td></td><td></td>
<td>E-11</td><td>AFD®</td><td>Gossypium hirsutum L. (Cotton)</td><td>Bayer CropScience</td><td>The lines include, for example, AFD5062LL, AFD5064F, AFD 5065B2F; AFD seeds are available in different varieties with integrated technology such as Bollgard®, Bollgard II, Roundup Ready, Roundup Ready Flex and LibertyLinlc® technologies.</td><td></td>
<td>E-12</td><td>Bollgard II®</td><td>Gossypium hirsutum L. (Cotton)</td><td>Monsanto Company</td><td>event MON 15985: Cry2 (A) b1; Cry1A (c)</td><td></td>
<td>E-13</td><td>Bollgard®</td><td>Gossypium hirsutum L.</td><td>Monsanto Company</td><td>Cry 1Ac</td><td></td>
<td></td><td></td><td>(Cotton)</td><td></td><td></td><td></td>
<td>E-14</td><td>FiberMax®</td><td>Gossypium hirsutum L. (Cotton)</td><td>Bayer CropScience</td><td></td><td></td>
<td>E-15</td><td>Liberty Link®</td><td>Gossypium hirsutum L. (Cotton)</td><td>Bayer CropScience</td><td>Phosphinothricin tolerance</td><td></td>
<td>E-16</td><td>Nucotn 33B</td><td>Gossypium hirsutum L. (Cotton)</td><td>Delta Pine and Land</td><td>Bt toxin in the Delta Pine lines: CrylAc</td><td></td>
<td>E-17</td><td>Nucotn 35B</td><td>Gossypium hirsutum L. (Cotton)</td><td>Delta Pine and Land</td><td>Bt toxin in Delta Pine lines: Cry1Ac</td><td></td>
<td>E-18</td><td>Nucotn®</td><td>Gossypium hirsutum L. (Cotton)</td><td>Delta Pine and Land</td><td>Bt toxin in Delta Pine lines</td><td></td>
<td>E-19</td><td>PhytoGen ™</td><td>Gossypium hirsutum L. (Cotton)</td><td>PhytoGen Seed Company, Dow AgroSciences LLC</td><td>includes grades that include, for example, Roundup Ready flex, Widestrike</td><td></td>
<td>E-20</td><td>Roundup Ready®</td><td>Gossypium hirsutum L. (Cotton)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td></td>
<td>E-21</td><td>Roundup Ready®</td><td>Gossypium hirsutum L. (Cotton)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td></td>
<td>E-22</td><td>Widestrike ™</td><td>Gossypium hirsutum L. (Cotton)</td><td>Dow AgroSciences LLC</td><td>Cry1F and Cry1Ac</td><td>Monsanto / Dow</td>
<td>E-23</td><td>YIELD GARD®</td><td>Gossypium hirsutum L. (Cotton)</td><td>Monsanto Company</td><td></td><td>http://www.garstseed.com/ GarstClient / Technology / a grisure.aspx</td>
<td>E-24</td><td>Roundup Ready®</td><td>Medicago sativa (alfalfa)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td></td>
<td>E-25</td><td>Clearfield®</td><td>Oryza sativa (rice)</td><td>BASF Corporation</td><td>non-GMO, imazamox tolerant</td><td></td>
<td>E-26</td><td>NewLeaf®</td><td>Solanum tuberosum L. (potato)</td><td>Monsanto Company</td><td>Resistance to infection with leaf roll virus (PLRV) and feeding damage of the Colorado potato beetle Leptinotarsa decemlineata</td><td></td>
<td>E-27</td><td>NewLeaf® plus</td><td>Solanum tuberosum L. (potato)</td><td>Monsanto Company</td><td>Resistance to infection with leaf roll virus (PLRV) and feeding damage of the Colorado potato beetle Leptinotarsa decemlineata</td><td>http: //www.dowagro.com/ phytogen / index .htm</td>
<td>E-28</td><td>Protecta®</td><td>Solanum tuberosum L.</td><td></td><td></td><td></td>
<td></td><td></td><td>(potato)</td><td></td><td></td><td></td>
<td>E-29</td><td>Clearfield®</td><td>sunflower</td><td>BASF Corporation</td><td>non-GMO, imazamox tolerant</td><td></td>
<td>E-30</td><td>Roundup Ready®</td><td>Triticum aestivum (wheat)</td><td>Monsanto Company</td><td>Glyphosate tolerance, NK603</td><td></td>
<td>E-31</td><td>Clearfield®</td><td>Wheat</td><td>BASF Corporation</td><td>non-GMO, imazamox tolerant</td><td></td>
<td>E-32</td><td>Agrisure® (family)</td><td>Zea mays L. (maize)</td><td>Syngenta Seeds, Inc.</td><td>these include Agrisure CB / LL (event BT 11 plus phosphinothricin tolerance by event GA21); Agrisure CB / LL / RW (event Bt 11, modified synthetic Cry3A gene, tolerance to phosphinothricin by event GA21); Agrisure GT (glyphosate tolerance); Agrisure GT / CB / LL (tolerance to glyphosate and phosphinothricin by event GA21, event Bt 11); Agrisure 3000GT (CB / LL / RW / GT: tolerance to glyphosate and phosphinothricin by GA21 event, event Bt 11, modified synthetic Cry3A gene); Agrisure GT / RW (glyphosate tolerance, modified synthetic Cry3A gene); Agrisure RW (modified synthetic Cry3A gene); future features</td><td></td>
<td>E-33</td><td>BiteGard®</td><td>Zea mays L. (maize)</td><td>Novartis Seeds</td><td>the cry1A gene (b)</td><td></td>
<td>E-34</td><td>Bt-Xtra®</td><td>Zea mays L. (maize)</td><td>DEKALB Genetics Corporation</td><td>the cry1Ac gene</td><td></td>
<td>E-35</td><td>Clearfield®</td><td>Zea mays L. (maize)</td><td>BASF Corporation</td><td>non-GMO, imazamox tolerant</td><td></td>
<td>E-36</td><td>Herculex® (family)</td><td>Zea mays L. (maize)</td><td>Dow AgroSciences LLC</td><td></td><td></td>
<td>E-37</td><td>IMI®</td><td>Zea mays L. (maize)</td><td>DuPont</td><td>Imidazolinone tolerance</td><td></td>
<td>E-38</td><td>KnockOut®</td><td>Zea mays L. (maize)</td><td>Syngenta Seeds, Inc.</td><td>SYN-EV176-9: cry1A (b) gene</td><td></td>
<td>E-39</td><td>Mavera®</td><td>Zea mays L. (maize)</td><td>Renessen LLC</td><td>rich in lysine</td><td>http: //www.dowagro.com/ widestrike /</td>
<td>E-40</td><td>NatureGard®</td><td>Zea mays L. (maize)</td><td>Mycogen</td><td>the cry1A gene (b)</td><td></td>
<td>E-41</td><td>Roundup Ready®</td><td>Zea mays L. (maize)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td>http://www.starlinkcorn.co m / starlinkcorn.htm</td>
<td>E-42</td><td>Roundup Ready® 2</td><td>Zea mays L. (maize)</td><td>Monsanto Company</td><td>Glyphosate tolerance</td><td></td>
<td>E-43</td><td>SmartStax</td><td>Zea mays L. (maize)</td><td>Monsanto Company</td><td>A combination of eight genes</td><td></td>
<td>E-44</td><td>StarLink®</td><td>Zea mays L. (maize)</td><td>Aventis CropScience -> Bayer CropScience</td><td>the Cry9c gene</td><td></td>
<td>E-45</td><td>STS®</td><td>Zea mays L. (maize)</td><td>DuPont</td><td>Tolerance to sulfonylureas</td><td></td>
<td>E-46</td><td>YIELD GARD®</td><td>Zea mays L. (maize)</td><td>Monsanto Company</td><td>Mon810, Cry1Ab1; resistance to European cornflower</td><td>http: //www.dowagro.com/ herculex / about / herculexfa mily /</td>
<td>E-47</td><td>YieldGard® Plus</td><td>Zea mays L. (maize)</td><td>Monsanto Company</td><td>Mon810xMon863, double combination, resistance to European corn borer and corn rootworm</td><td></td>
<td>E-48</td><td>YieldGard® Rootworm</td><td>Zea mays L. (maize)</td><td>Monsanto Company</td><td>Mon863, Cry3Bb1, corn rootworm resistance</td><td></td>
<td>E-49</td><td>YieldGard® VT</td><td>Zea mays L. (maize)</td><td>Monsanto Company</td><td>Combination of features</td><td></td>
<td>E-50</td><td>YieldMaker TM</td><td>Zea mays L. (maize)</td><td>DEKALB Genetics Corporation</td><td>includes Roundup Ready 2, YieldGard VT, YieldGard Corn Borer, YieldGard Rootworm and YieldGard Plus technology</td><td></td>
[0102] The transgenic crop plants that can be treated according to the invention are preferably plants that contain a transformation event (transformation-integration events) or a combination of transformation events (transformation-integration events), and are for example listed in databases for various national or regional offices. registrations, including event 1143-14A (cotton, insect control, unfolded, disclosed in WO2006 / 128569); event 1143-51B (cotton, insect control, unfolded, disclosed in WO2006 / 128570); event 1445 (cotton, herbicide tolerance, unfolded, disclosed in US2002120964 or WO2002 / 034946); event 17053 (rice, herbicide tolerance, deposited as PTA-9843, disclosed in WO2010 / 117737); event 17314 (rice, herbicide tolerance, deposited as PTA-9844, disclosed in WO2010 / 117735); event 281-24-236 (cotton, insect control herbicide tolerance, deposited as PTA-6233, disclosed in WO2005 / 103266 or US2005216969); event 3006-210-23 (cotton, insect control herbicide tolerance, deposited as PTA-6233, disclosed in US2007143876 or WO2005 / 103266); event 3272 (maize, quality trait (Trait), deposited as PTA-9972, disclosed in WO2006098952 or US2006230473); event 40416 (maize, insect control - herbicide tolerance, deposited as ATCC PTA-11508, disclosed in WO2011 / 075593); event 43A47 (maize, insect control - herbicide tolerance, deposited as ATCC PTA-11509, disclosed in WO2011 / 075595); event 5307 (maize, insect control, deposited as ATCC PTA-9561, disclosed in WO2010 / 077816); event ASR-368 [bent grass, herbicide tolerant, deposited as ATCC PTA-4816, disclosed in US2006162007 or WO2004053062]; event B16 (maize, herbicide tolerance, unfolded, disclosed in US2003126634); event BPS-CV127-9 (soybeans, herbicide tolerance, deposited as NCIMB No. 41603, disclosed in WO2010 / 080829); event CE43-67B (cotton, insect control, filed as DSM ACC2724, disclosed in US2009217423 or WO2006 / 128573); event CE44-69D (cotton, insect control, unfolded, disclosed in US20100024077); event CE44-69D (cotton, insect control, unfolded, disclosed in WO2006 / 128571); event CE46-02A (cotton, insect control, unfolded, disclosed in WO2006 / 128572); event COT102 (cotton, insect control, unfolded, disclosed in US2006130175 or WO2004039986); event COT202 (cotton, insect control, unfolded, disclosed in US2007067868 or WO2005054479); event COT203 (cotton, insect control, unfolded, disclosed in WO2005 / 054480); event DAS40278 (maize herbicide tolerance deposited as ATCC PTA-10244, disclosed in WO2011 / 022469); event DAS-59122-7 (maize, insect control - herbicide tolerance, deposited as ATCC PTA 11384, disclosed in US2006070139); event DAS59132 (maize, insect control - herbicide tolerance, unfolded, disclosed in WO2009 / 100188); event DAS68416 (soybean herbicide tolerance, deposited as ATCC PTA-10442, disclosed in WO2011 / 066384 or WO2011 / 066360); event DP098140-6 (maize herbicide tolerance deposited as ATCC PTA-8296, disclosed in US2009137395 or WO2008 / 112019); event DP-305423-1 (soybeans, quality feature, uncomposed, disclosed in US2008312082 or WO2008 / 054747); event DP-32138-1
-83 (maize, hybrid system, folded as ATCC PTA-9158, disclosed in US20090210970 or WO2009 / 103049); event DP-356043-5 (soybean herbicide tolerance, deposited as ATCC PTA-8287, disclosed in US20100184079 or WO2008 / 002872); EE-1 event (eggplant, insect control, unfolded, disclosed in WO2007 / 091277); event FI117 (maize herbicide tolerance, deposited as ATCC 209031, disclosed in US2006059581 or WO1998 / 044140); GA21 event (maize herbicide tolerance, deposited as ATCC 209033, disclosed in US2005086719 or WO1998 / 044140); GG25 event (maize herbicide tolerance, deposited as ATCC 209032, disclosed in US2005188434 or WO1998 / 044140); event GHB119 (cotton, insect control-herbicide tolerance, deposited as ATCC PTA-8398, disclosed in WO2008 / 151780); event GHB614 (herbicide tolerant cotton deposited as ATCC PTA-6878, disclosed in US2010050282 or WO2007 / 017186); GJ11 event (maize herbicide tolerance, deposited as ATCC 209030, disclosed in US2005188434 or WO1998 / 044140); GM event RZ13 (sugar beet, virus resistance, deposited as NCIMB-41601, disclosed in WO2010 / 076212); event H7-1 (sugar beet herbicide tolerance deposited as NCIMB 41158 or NCIMB 41159, disclosed in US2004172669 or WO2004 / 074492); JOPLIN1 event (wheat, resistance to unassembled fungi, disclosed in US2008064032); event LL27 (soybean herbicide tolerance, compounded as NCIMB41658, disclosed in WO2006 / 108674 or US2008320616); event LL55 (soybean herbicide tolerance, compounded as NCIMB 41660, disclosed in WO2006 / 108675 or US2008196127); event LLcotton25 (herbicide tolerant cotton deposited as ATCC PTA-3343, disclosed in WO2003013224 or US2003097687); LLRICE06 event (rice herbicide tolerance deposited as ATCC-23352, disclosed in US6468747 or WO2000 / 026345); LLRICE601 event (rice herbicide tolerance deposited as ATCC PTA-2600, disclosed in US20082289060 or WO2000 / 026356); event LY038 (maize, quality feature, deposited as ATCC PTA-5623, disclosed in US2007028322 or WO2005061720); event MIR162 (maize, insect control, deposited as PTA-8166, disclosed in US2009300784 or WO2007 / 142840); event MIR604 (maize, insect control, unassembled, disclosed in US2008167456 or WO2005103301); event MON15985 (cotton, insect control, filed as ATCC PTA-2516, disclosed in US2004-250317 or WO2002 / 100163); event MON810 (maize, insect control, unassembled, disclosed in US2002102582); event MON863 (maize, insect control, deposited as ATCC PTA-2605, disclosed in WO2004 / 011601 or US2006095986); event MON87427 (maize, pollination control, deposited as ATCC PTA-7899, disclosed in WO2011 / 062904); event MON87460 (maize, stress tolerance, complexed as ATCC PTA-8910, disclosed in WO2009 / 111263 or US20110138504); event MON87701 (soybean, insect control, deposited as ATCC PTA-8194, disclosed in US2009130071 or WO2009 / 064652); event MON87705 (soybeans, quality trait herbicide tolerance, deposited as ATCC PTA-9241, disclosed in US20100080887 or WO2010 / 037016); event MON87708 (soybean herbicide tolerance, deposited as ATCC PTA9670, disclosed in WO2011 / 034704); event MON87754 (soybeans, feature
Qualities, deposited as ATCC PTA-9385, disclosed in WO2010 / 024976); event MON87769 (soybean quality feature, deposited as ATCC PTA-8911, disclosed in US20110067141 or WO2009 / 102873); event MON88017 (maize, insect control - herbicide tolerance, deposited as ATCC PTA-5582, disclosed in US2008028482 or WO2005 / 059103); event MON88913 (herbicide tolerant cotton, filed as ATCC PTA-4854, disclosed in WO2004 / 072235 or US2006059590); event MON89034 (maize, insect control, deposited as ATCC PTA-7455, disclosed in WO2007 / 140256 or US2008260932); event MON89788 (soybean herbicide tolerance, deposited as ATCC PTA-6708, disclosed in US2006282915 or WO2006 / 130436); MS11 event (canola, pollination control-herbicide tolerance, deposited as ATCC PTA-850 or PTA-2485, disclosed in WO2001 / 031042); MS8 event (canola, pollination control-herbicide tolerance, deposited as ATCC PTA-730, disclosed in WO2001 / 041558 or US2003188347); event NK603 (maize herbicide tolerance, deposited as ATCC PTA-2478, disclosed in US2007-292854); PE-7 event (rice, insect control, unassembled, disclosed in WO2008 / 114282); RF3 event (canola, pollination control-herbicide tolerance, deposited as ATCC PTA-730, disclosed in WO2001 / 041558 or US2003188347); RT73 event (canola, herbicide tolerance, unfolded, as disclosed in WO2002 / 036831 or US2008070260); event T227-1 (sugar beet herbicide tolerant, unfolded, as disclosed in WO2002 / 44407 or US2009265817); event T25 (maize, herbicide tolerance, unfolded, disclosed in US2001029014 or WO2001 / 051654); event T304-40 (cotton, insect control herbicide tolerance, deposited as ATCC PTA-8171, disclosed in US2010077501 or WO2008 / 122406); event T342-142 (cotton, insect control, unfolded, disclosed in WO2006 / 128568); event TC1507 (maize, insect control - herbicide tolerance, unfolded, disclosed in US2005039226 or WO2004 / 099447); event VIP1034 (maize, insect control-herbicide tolerance, deposited as ATCC PTA3925, disclosed in WO2003 / 052073); event 32316 (maize, insect control herbicide tolerance, deposited as PTA-11507, disclosed in WO2011 / 084632); event 4114 (maize, insect control - herbicide tolerance, deposited as PTA-11506, disclosed in WO2011 / 084621).
The plants listed can be treated with the active compound mixture according to the invention with particular advantage according to the invention. The preferred ranges stated above for the mixtures also apply to the treatment of these plants. The treatment of plants with the mixtures mentioned especially in this text is particularly distinguished.
[0104] The control of animal pests, especially nematodes, by treating the seeds of plants has been known for a long time and is the subject of continuous improvement. Nevertheless, a number of problems arise with the treatment of seeds that cannot always be satisfactorily solved. Thus, it is worth the effort to develop methods of protecting seeds and germinating plants which make the additional spread of plant protection products after sowing or after emergence of the plants unnecessary, or at least significantly reduce it. Moreover, it is worth trying to optimize the amount of active compound used so far that the seeds and germinating plants are as well protected as possible against pest infestation.
-85 animals, especially nematodes, but the plant itself is not harmed by the active substance used. The seed treatment methods should also address, in particular, the intrinsic insecticidal properties of the transgenic plants to achieve optimal protection of the seeds and germinating plants with a minimum of plant protection agents.
The invention therefore relates in particular to a method for protecting seeds and germinating plants against infestation by animal pests, in particular nematodes, as well as a method for increasing the yield by treating the seeds with an agent according to the invention.
[0106] The invention also relates to the use of the compositions according to the invention for the treatment of seeds for the protection of seeds and germinating plants against animal pests, in particular nematodes, and for increasing the yield.
The invention further relates to seeds which have been treated with an agent according to the invention for protection against animal pests, in particular nematodes.
[0108] One of the advantages of the invention is that, due to the particular systemic properties of the agents according to the invention, the treatment of seeds with these agents protects not only the seeds themselves, but also the emerged plants thereof, against animal pests, especially nematodes. In this way, direct treatment of the crop at the time of sowing or shortly thereafter can be omitted.
[0109] It is likewise considered advantageous that the mixtures according to the invention can also be used in particular with transgenic seeds.
Formulations
[0110] The active substances can be converted into generally accepted formulations for foliar and soil application, such as solutions, emulsions, spraying powders, suspensions, powders, dusts, pastes, soluble powders, granules, suspension-emulsion concentrates, active substance-impregnated natural and synthetic materials as well as microcapsules in polymeric substances.
These formulations are prepared in a known manner, e.g. by mixing the active substances with diluting agents, i.e. liquid solvents and / or solid carrier substances, optionally by using surface-active agents, i.e. emulsifying agents and / or dispersing agents and / or or foaming agents.
In the case of the use of water as an extender, organic solvents can, for example, also be used as auxiliary solvents. Suitable liquid solvents are in principle: aromatics, such as xylene, toluene or alkyl naphthalenes, chlorinated aromatics or chlorinated aliphatic hydrocarbons, such as chlorobenzoles, chloroethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, e.g. petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol as well as their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide and dimethyl sulfoxide and water.
-86 The following are considered solid support materials:
[0113] e.g. ammonium salts and natural rock powders such as kaolins, clayey earths, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth and synthetic rock powders such as highly dispersed silicic acid, aluminum oxide and silicates as solid carrier substances for granulates are taken into account: e.g. broken and fractionated natural rocks such as calcite, marble, pumice stone, sepiolite, dolomite as well as synthetic granules of inorganic and organic meals and granules of organic materials such as sawdust, coconut shells, corn cobs and tobacco stalks; as emulsifying and / or foaming agents there are suitable: e.g. nonionogenic and anionic emulsifiers, such as polyoxyethyl fatty acid esters, polyoxyethyl ethers of fatty alcohols, e.g. alkylaryl polyglycol ether, alkyl sulfonates, alkyl sulfates, aryl sulfonates as well as protein hydrolysates; as dispersants come into consideration: for example lignosulfide liquors and methylcellulose.
[0114] Adhesives such as carboxymethyl cellulose, natural and synthetic powdered, granular or latex-like polymers such as gum arabic, polyvinyl alcohol, polyvinyl acetate as well as natural phospholipids such as kephalins and lecithins and synthetic phospholipids can be used in the formulations. Mineral and vegetable oils can be used as further additives.
[0115] Dyes such as inorganic pigments, e.g. iron oxide, titanium oxide, iron cyan blue, and organic dyes, such as alizarin, azo and metal phthalocyanine dyes, and trace nutrients such as iron, manganese, boron, copper salts, may be used. cobalt, molybdenum and zinc.
[0116] The formulations usually contain between 0.1 and 95% by weight of active ingredient, preferably between 0.5 and 90%.
[0117] The active substance combinations according to the invention may be present in commercial formulations as well as in forms prepared therefrom, used in mixtures with other active substances, such as insecticides, attractants, sterilization preparations, bactericides, acaricides, nematicides, fungicides, regulating substances. growth or herbicides. The insecticides include, for example, phosphoric acid esters, carbamates, carboxylic acid esters, chlorinated hydrocarbons, phenylureas, substances produced by microorganisms, etc.
A mixture with other known active substances, such as herbicides, or with fertilizers and growth regulators is also possible.
[0119] The active substance combinations may furthermore be present when used as insecticides in their commercially available formulations as well as in forms prepared from these formulations used in admixture with synergists. Synergists are compounds which increase the effectiveness of active substances, although the added synergist need not be active itself.
[0120] The active substance content of the use form prepared from commercially accepted formulas can be varied within wide ranges. The concentration of the active substance
The forms used can be from 0.0000001 up to 95% by weight of active ingredient, preferably between 0.0001 and 50% by weight.
[0121] The application takes place in one of the application forms suited to the method adopted.
Application form
When the active substances according to the invention are used for controlling animal pests, in particular nematodes, the application rates can vary widely depending on the type of use. The amount of active substances used according to the invention is • when treating parts of plants, e.g. of leaves: 0.1 to 10,000 g / ha, preferably 10 to 1,000 g / ha, particularly preferably 50 to 300 g / ha (when applied by dripping or dripping, the application rate can be limited, especially when applying inert substrates such as rock wool or perlite);
• for seed treatment: from 2 to 200 g per 100 kg of seed, preferably from 3 to 150 g per 100 kg of seed, particularly preferably from 2.5 to 25 g per 100 kg of seed, particularly very preferably from 2.5 to 12, 5 g per 100 kg of seeds;
• when treating the substrate: 0.1 to 10,000 g / ha, preferably 1 to 5,000 g / ha.
[0123] These amounts used are given by way of example only and are not limiting in the context of the invention.
[0124] The active substances according to the invention or agents can also be used for the protection of plants for a certain period of time after treatment against invasion by animal pests, especially nematodes. The period of time during which the protection is carried out is usually from 1 to 28 days, preferably 1 to 14 days, particularly preferably from 1 to 10 days, particularly very preferably from 1 to 7 days after the treatment of the plants with the active substances or up to 200 days after treatment. dressing the seeds.
Foliar applications
By foliar application is meant the treatment of plants and plant parts according to the invention with the active substances directly or by influencing their surroundings, environment or storage place according to generally accepted methods of treatment, e.g. by dipping, spraying, fogging, fogging, sprinkling, rubbing in. , or by injection. Plant parts are understood to mean all above-ground and underground parts and organs of plants, such as shoot, leaf, flower and root, including, for example, leaves, needles, stems, trunks, flowers, fruiting bodies, fruits and seeds as well as roots, tubers and rhizome. Plant parts also include crops as well as vegetative and generative seed, for example cuttings, tubers, rhizomes, runners and seeds.
-88 Soil application
[0126] By soil application is meant the control of insects and / or spider mites and / or nematodes by flooding (infiltration) with soil pesticides, soil incorporation or irrigation systems as soil drip application. Alternatively, the active ingredient combinations according to the invention can be spread in solid form (e.g. in the form of granules) in the position of the plants. In wild rice cultivation, this can also take place by dosing the active compound combination according to the invention in solid application form (e.g. as granules) over a flooded rice field.
The invention relates to application forms on natural (soil-rich) or artificial substrates (e.g. mineral wool, glass wool, quartz sand, gravel, expanded clay, vermiculite) outdoors or in closed systems (e.g. greenhouses or covered with foil) and in annual (e.g. vegetables, potatoes, cotton, beetroot, ornamental plants) or perennial crops (e.g. citrus, fruit, tropical crops, spices, nuts, wine, conifers and ornamentals). Furthermore, it is possible to spread the active substances according to the Ultra-Low-Volume method or in the preparation of the active substances or to inject the active substance itself into the soil.
Dressing the seeds
The active compound combinations according to the invention are particularly suitable for the protection of the seeds of all plant species which are used in agriculture, in a greenhouse, in a forest or in horticulture against previously applied animal pests, in particular against nematodes. These are in particular cereal seeds (such as wheat, barley, rye, millet, oats), corn, cotton, soybeans, rice, potatoes, sunflower seeds, beans, coffee, beetroot (e.g. sugar beet and fodder beet), peanut, vegetables (such as tomato, cucumber, onion and lettuce), lawn and ornamental plants. The seed treatments of cereals (such as wheat, barley, rye and oats), corn and rice, and treated cotton and soybeans are of particular importance.
[0129] Within the scope of this invention, the agent according to the invention is spread alone or in a suitable formulation to the seeds. Preferably the seed is treated in a state in which it is so stable that no damage occurs during treatment. In general, seed treatment can take place at any time between harvesting and sowing. Typically seeds are used that have been separated from the plant and freed from the cob, shell, stem, casing, wool or flesh of the fruit. Thus, for example, seeds that have been harvested, cleaned and dried to a moisture content of less than 15% by weight may be used. Alternatively, seed may be used which, after drying, has been treated with e.g. water and then dried again.
[0130] In general, when treating seeds, care must be taken that the amount of the agent according to the invention spread on the seeds and / or further additives is selected such that it does not reduce the germination of the seeds or harm the plants derived therefrom. This must be observed in particular with active compounds which may have phytotoxic effects in the specified amounts used.
The active ingredient / agent combinations according to the invention can be spread directly, i.e. without containing further components and without dilution. As a rule, it is preferable to spread the remedies over the seeds in a suitable formula. Suitable formulations and methods for seed treatment are known to those skilled in the art and are described e.g. in the following documents: US 4,272,417 A, US 4,245,432 A, US 4,808,430 A, US 5,876,739 A, US 2003/0176428 A1, WO 2002/080675 A1, WO 2002/028186 A2.
[0132] The active ingredient combinations that can be used according to the invention can be converted into conventional stain formulations, such as solutions, emulsions, suspensions, powders, foams, slurries or other seed coatings, as well as ULV formulations.
These formulations are prepared in a known manner by mixing the active substances with conventional additives, such as, for example, conventional diluents as well as solvents or diluting agents, dyes, wetting agents, dispersing agents, emulsifiers, antifoams, preservatives, secondary thickeners. , glues, gibberellins and also water.
[0134] As dyes which may be included in the stain formulations that can be used according to the invention, all dyes conventional for the purpose are suitable. In this case, both poorly water-soluble pigments and water-soluble dyes can be used. Examples are the dyes known under the names Rhodamin B, CI Pigment Red 112 and CI Solvent Red 1.
[0135] As wetting agents that can be included in the stain formulations that can be used according to the invention, all conventional agrochemical active ingredient formulations that promote wetting are contemplated. Alkyl naphthalene sulfonates, such as diisopropyl or diisobutyl naphthalene sulfonates, are preferably used.
[0136] Suitable dispersants and / or emulsifiers which can be included in the staining agent formulations that can be used according to the invention, all non-ionogenic, anionic and cationic dispersants conventional for agrochemical active ingredient formulation are contemplated. Preferably, non-ionic or anionic dispersants or mixtures of non-ionic or anionic dispersants are possible. Suitable nonionic dispersants are, in particular, ethylene oxide-propylene oxide block polymers, alkylphenol polyglycol ethers as well as tristryrylphenol polyglycol ethers and their phosphated or sulphated derivatives. Preferred anionic dispersants are especially lignin sulfonates, polyacrylic acid salts and arylsulfonate-formaldehyde condensates.
[0137] All foam-inhibiting substances which are conventional for agrochemical active ingredient formulations can be included as antifoams in the stain formulations that can be used according to the invention.
Silicone antifoams and magnesium stearate are preferably used.
All substances that can be used in agrochemicals for this purpose can be contained as preservatives in the stain formulations which can be used according to the invention. Mention may be made, for example, of dichlorophen and the hemiformal of benzyl alcohol.
[0139] Suitable secondary thickeners which can be included in the stain formulations that can be used according to the invention, all substances customary for this purpose in agrochemicals are contemplated. Preferred are cellulose derivatives, acrylic acid derivatives, xanthan, modified clays and highly dispersed silica.
[0140] Suitable adhesives that can be included in the stain formulations that can be used according to the invention, all possible adhesives are suitable. Preferably, polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose are mentioned.
[0141] Gibberellins which can be included in the stain formulations which can be used according to the invention are preferably gynerelins A1, A3 (= gibberellic acid), A4 and A7, and particularly preferably gibberellic acid. Gibberellins are known (cf. R. Wegler "Chemie der Pflanzenschutz- und Schadlingsbekampfungsmittel", Bd. 2, Springer Verlag, 1970, pp. 401-412).
[0142] The stain formulations that can be used according to the invention may be used either directly or after dilution with water in advance for the treatment of seeds of a wide variety of species. Thus, the concentrates or preparations obtainable therefrom by dilution with water can be used for the staining of the seeds of cereals, such as wheat, barley, rye, oats and triticale, as well as seeds of corn, rice, rapeseed, peas, beans, cotton, soybeans, sunflowers and beetroots or also vegetable seeds of a different nature. The staining agent formulations that can be used according to the invention or their diluted formulations can also be used for staining the seeds of transgenic plants. In this connection, additional synergistic effects can also occur in conjunction with the substances formed by the expression.
[0143] For the treatment of seed with formulations of staining agents that can be used according to the invention or formulations prepared therefrom by adding water with formulations, all conventional mixing devices that can be used for the staining are contemplated. In detail, the staining is carried out in such a way that the seeds are fed into a mixer, which in each case adds the desired amounts of the staining formulations, either as such or after dilution with water in advance, and agitates until the formulation is evenly distributed over the seeds. Alternatively, there is a drying process.
[0144] The amount of stain formulations to be used according to the invention may be varied within a larger range. It depends on the respective content of active substances in the formulations and on the seeds. Combinations used
The active substances are usually between 0.001 and 50 g per kilogram of seed, preferably between 0.01 and 25 g per kilogram of seed.
Formula for calculating the mortality rate of a combination of two active substances
[0145] The expected effect for a given combination of two active substances can be calculated (cf. COLBY, SR; "Caculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 15, pp. 20-22, 1967);
if
X is the mortality rate, expressed as% of the untreated control, using an applied amount of active substance A of m ppm, or mg / ha
Y is the mortality rate, expressed as% of the untreated control, when applied amount of active substance B is n ppm, or ng / ha
E is the mortality rate, expressed as% of the untreated control, using active substances A and B in application rates of min ppm or ming / ha, then this means
ΧΎ E = X <sub>+</sub> Y [0146] If the actual insecticidal mortality rate is greater than that calculated, then the combination is hyperadditive in its kill, ie there is a synergistic effect. In this case, the actually observed kill rate must be greater than the expected kill rate (E) calculated using the above formula.
Example 1:
[0147] Myzus Study (Spray Treatment)
Solvent: 78 parts by weight of acetone
1.5 parts by weight of dimethylformamide
Emulsifier: 0.5 part by weight of an alkylaryl polyglycol ether
To prepare a suitable preparation of active ingredient, 1 part by weight of active ingredient is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water containing the emulsifier to the desired concentration. To prepare a suitable suspension of the biological agent, cells, spores or viruses are diluted with water containing an emulsifier at the desired concentration.
[0149] Leaf blades of Chinese cabbage (Brassica pekinensis) that are infected with all stages of green peach aphid (Myzus persicae) are sprayed with a preparation of the active compound at the desired concentration.
[0150] After the desired time, the action in% was determined. 100% means that all the aphids have been killed; 0% means that no aphids have been killed. The killing values obtained are calculated according to the Colbi formula (see sheet 1).
[0151] In this test, the following combination of fluopyram with an additional active or biological agent according to this application had a synergistically enhanced efficacy compared to the substances used alone:
Table 1-1: Study of Myzus persicae
<td>Active substance / biological factor</td><td>Concentration g ai / ha</td><td>Mortality in% after d 1</td>
<td>fluopyram</td><td> 1000 500</td><td> 0 0</td>
<td>imicyafos</td><td> 67,5</td><td> 0</td>
<td>fluopyram + imicyafos</td><td> 1000 + 67,5</td><td>stated * calculated ** 100 0</td>
<td>pyrethrum</td><td> 100</td><td> 80</td>
<td>fluopyram + pyrethrum ***</td><td> 1000 +100</td><td>stated * calculated ** 100 80</td>
<td>fluensulfone</td><td> 2000</td><td> 0</td>
<td>fluopyram + fluenesulfone ***</td><td> 500 + 2000</td><td>stated * calculated ** 90 0</td>
<td>Paecilomyces lilacinus strain 251</td><td> 5000</td><td> 0</td>
<td>fluopyram + Paecilomyces lilacinus strain 251 ***</td><td> 1000 + 5000</td><td>stated * calculated ** 70 0</td>
<td>Bacillus amyloliquefaciens strain FZB 42</td><td> 2000</td><td> 0</td>
<td>fluopyram + Bacillus amyloliquefaciens ***</td><td> 1000 +2000</td><td>stated * calculated ** 90 0</td>
<td>Cydia pomonella granulosis virus (CpGV)</td><td> 1000</td><td> 0</td>
<td>fluopyram + Cydia pomonella granulosis virus</td><td></td><td>stated **</td><td>calculated **</td>
<td>(CpGV) ***</td><td> 1000 +1000</td><td> 70</td><td> 0</td>
Table 1-2: Study - Myzus persicae
<td>Active substance / biological factor</td><td>Concentration g ai / ha</td><td>Λ ........<sup>d</sup>Mortality in% after 6</td>
<td>fluopyram</td><td> 1000 500</td><td> 0 0</td>
<td>Bacillus thuringiensis subspecies tenebrionis</td><td> 1000</td><td> 0</td>
<td>fluopyram + Bacillus thuringiensis subspecies tenebrionis ***</td><td> 1000+1000</td><td>stated * calculated ** 80 0</td>
<td>azadirachtin</td><td> 100</td><td> 0</td>
<td>fluopyram + azadirachtin ***</td><td> 1000+ 100</td><td>stated * calculated ** 70 0</td>
<td>Metschnikowia fructicola</td><td> 1000</td><td> 0</td>
<td>fluopyram + Metschnikowia fructicola ***</td><td> 500+ 1000</td><td>stated * calculated ** 90 0</td>
<td colspan="3">* states = insecticidal activity known, ** calculated = calculated operation according to the Colbi formula *** = not according to the invention</td>
Example 2: (not according to the invention)
[0152] Spodoptera frugiperda test (spray treatment)
Solvent: 78.0 parts by weight of acetone
1.5 parts by weight of dimethylformamide
Emulsifier: 0.5 part by weight of an alkylaryl polyglycol ether
To prepare a suitable preparation of active ingredient, 1 part by weight of active ingredient is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water containing the emulsifier to the desired concentration.
[0154] Corn leaves (Zea mays) are treated by spraying with a preparation of active ingredient of the desired concentration and, after drying, infested with owl caterpillars (Spodoptera frugiperda).
[0155] After the desired time, the action in% was determined. 100% means that all caterpillars have been exterminated; 0% means that no caterpillars have been exterminated. The mortality values obtained are calculated according to the Colbi formula (see sheet 1).
[0156] In this test the following combination of fluopyram with an additional active compound according to this application had a synergistically enhanced efficacy compared to the active substances used alone:
Table 2: Study of Spodoptera frugiperda
<td>Active substance / biological factor</td><td>Concentration g ai / ha</td><td>Mortality in% after 2<sup>d</sup></td>
<td>fluopyram</td><td> 1000</td><td> 0</td>
<td>pyrethrum</td><td> 100</td><td> 33</td>
<td>fluopyram + pyrethrum</td><td> 1000+ 100</td><td>stated * calculated ** 50 33</td>
<td colspan="3">* Statement = insecticidal activity known, ** calculated = calculated operation according to the Colbi formula</td>
Example 3 (not according to the invention):
Seed treatment - Cotton emergence study
[0157] Cotton seed (Gossypium hirsutum) is mixed with the desired amount of active ingredient and spores and water. After drying, 25 grains were sown in pots filled with sandy loam.
[0158] After 2 days, the% efficacy was determined from the emerging cotton plants. The following combination of fluopyram and a biological agent had a better emergence rate compared to the alone substances and untreated controls:
Table 3: Cotton emergence
<td>Active substance / biological factor</td><td>Concentration of g ai / kg of seeds</td><td>% emergence compared to the untreated control</td>
<td>Control (untreated seeds)</td><td></td><td> 100</td>
<td>fluopyram</td><td> 1 0,5</td><td> 133 100</td>
<td>Bacillus subtilis strain GB 03</td><td> 0,078</td><td> 158</td>
<td>fluopyram + B. subtilis strain GB 03</td><td> 0,5 + 0,078</td><td> 288</td>
<td>Bacillus amyloliquefaciens strain FZB 42</td><td> 0,15 0,075</td><td> 163 158</td>
<td>fluopyram + B. amyloliquefaciens strain FZB 42</td><td> 1,0 + 0,15 0,5 + 0,075</td><td> 225 221</td>
<td colspan="2">* Statement = insecticidal activity known, Colbi's formula</td><td>** cal. = calculated action according to</td>
Example 4: (not according to the invention) Test Meloidogyne incognita solvent: 125.0 parts by weight of acetone
[0159] To prepare a suitable preparation of the active ingredient, 1 part by weight of the active ingredient is mixed with the stated amounts of solvent and the concentrate is diluted with water to the desired concentration. To prepare a spore suspension, the spores are diluted with water to the desired concentration.
[0160] The dishes were filled with sand, active ingredient solution, Meloidogyne incognita egg suspension larvae and lettuce seeds. Lettuce seeds germinate and plants develop. Galls develop on the roots.
After the desired time, the nematode efficacy in% is determined from the formation of galls. 100% means that no gaskets were found; 0% means that the number of jellies on the treated plants corresponds to that of the untreated control. The values obtained are converted according to the Colbi formula (see sheet 1).
[0162] In this test, the following combination of fluopyram and the biological agent of this application had synergistically enhanced efficacy compared to the active ingredients used alone:
Table 4: Meloidogyne incognita study
<td>Active substance / biological factor</td><td>Concentration in ppm</td><td>Mortality in% after 21<sup>d</sup></td>
<td>fluopyram</td><td> 0,0005</td><td> 0</td>
<td>Metarhizium anisopliae strain F52</td><td> 5</td><td> 0</td>
<td>fluopyram + M. anisopliae strain F52</td><td> 0,0005 + 5</td><td>stated * calculated ** 80 0</td>
<td colspan="3">* Statement = insecticidal activity known, ** calculated = calculated operation according to the Colbi formula</td>
Example 5: Glycine max - growth promotion in combination with mycorrhiza
[0163] Soybeans (Glycine max) are mixed with the desired amount of active ingredient in water. After drying, the seeds were sown in pots filled with sand and perlite (1: 1). For inoculation with arbuscular mycorrhiza fungi, a sand-perlite mixture is previously mixed with the mycorrhiza inoculum (AMykor GmbH; Germany) at a concentration of 25 ml / l. The seeds were covered with 3 cm of Lecaton (clay).
[0164] During the following 44 days, the plants are grown in a greenhouse under good growth conditions. The pots are watered with a nutrient solution (Hoagland and Arnon, 1950, semi-concentrated solution) with a low concentration of phosphate (20 μΜ).
[0165] Untreated control plants were grown without the arbuscular mycorrhiza fungus but under the same conditions.
[0166] The shoot and root growth promoting effect is determined by the weight of the fresh roots of the treated plants compared to the untreated control.
[0167] The following combination of active ingredient and biological agent shows enhanced root growth compared to those of the separate applications and controls:
Table 5: Soybean Plant Growth
<td>Active substance / biological factor</td><td>Concentration mg / grain</td><td>root weight in% compared to the untreated control</td>
<td>control</td><td> -</td><td> 100</td>
<td>fluopyram</td><td> 0,1</td><td> 116,90</td>
<td>arbuscular mycorrhiza fungus</td><td> -</td><td> 133,21</td>
<td>fluopyram + arbuscular mycorrhiza fungus</td><td> 0,1</td><td> 137,91</td>
2 sheets
Sheet 1 Sheet 2
123 members in 16 offices
Priority claims11
| Document | Office | Kind | Date |
|---|---|---|---|
| 10193335 | European Patent Office (EPO) | A | |
| 41943810 | United States of America | P | |
| 11788536 | European Patent Office (EPO) | A | |
| 16173007 | European Patent Office (EPO) | A | |
| 10193335 | – | – | – |
| 161730072 | – | – | – |
| 419438P | – | – | – |
| EP20100193335 | – | – | – |
| EP20110788536 | – | – | – |
| EP20160173007 | – | – | – |
| US20100419438P | – | – | – |
Members123
| Document | Office | Kind | |
|---|---|---|---|
| EP2460407A1 | European Patent Office (EPO) | A1 | |
| CA2819270A1 | Canada | A1 | |
| CA3033426A1 | Canada | A1 | |
| CA3033429A1 | Canada | A1 | |
| CA3033430A1 | Canada | A1 | |
| CA3033431A1 | Canada | A1 | |
| CA3033448A1 | Canada | A1 | |
| CA3033465A1 | Canada | A1 | |
| CA3033471A1 | Canada | A1 | |
| CA3033588A1 | Canada | A1 | |
| CA3033766A1 | Canada | A1 | |
| CA3033795A1 | Canada | A1 | |
| CA3033801A1 | Canada | A1 | |
| WO2012072696A1 | World Intellectual Property Organization (WIPO) | A1 | |
| EP2645857A1 | European Patent Office (EPO) | A1 | |
| CO6801721A2 | Colombia | A2 | |
| CN103429080A | China | A | |
| JP2013544269A | Japan | A | |
| US2014005047A1 | United States of America | A1 | |
| KR20140001235A | Republic of Korea | A | |
| CN104824034A | China | A | |
| CN104824036A | China | A | |
| CN104824043A | China | A | |
| CN104886081A | China | A | |
| CN104938522A | China | A | |
| CN104957173A | China | A | |
| CN104957174A | China | A | |
| CN104957175A | China | A | |
| UA110356C2 | Ukraine | C2 | |
| UA111054C2 | Ukraine | C2 | |
| UA111313C2 | Ukraine | C2 | |
| CN103429080B | China | B | |
| UA111569C2 | Ukraine | C2 | |
| CN105594749A | China | A | |
| CN105638738A | China | A | |
| UA112037C2 | Ukraine | C2 | |
| UA112038C2 | Ukraine | C2 | |
| BR112013013402A2 | Brazil | A2 | |
| UA112144C2 | Ukraine | C2 | |
| JP5964849B2 | Japan | B2 | |
| UA112501C2 | Ukraine | C2 | |
| EP3092900A1 | European Patent Office (EPO) | A1 | |
| EP3103333A1 | European Patent Office (EPO) | A1 | |
| EP3103334A1 | European Patent Office (EPO) | A1 | |
| EP3103335A1 | European Patent Office (EPO) | A1 | |
| EP3103336A1 | European Patent Office (EPO) | A1 | |
| EP3103337A1 | European Patent Office (EPO) | A1 | |
| EP3103338A1 | European Patent Office (EPO) | A1 | |
| EP3103339A1 | European Patent Office (EPO) | A1 | |
| EP3103340A1 | European Patent Office (EPO) | A1 | |
| EP3103341A1 | European Patent Office (EPO) | A1 | |
| EP3103342A1 | European Patent Office (EPO) | A1 | |
| EP3103343A1 | European Patent Office (EPO) | A1 | |
| EP3103344A1 | European Patent Office (EPO) | A1 | |
| UA114660C2 | Ukraine | C2 | |
| UA115892C2 | Ukraine | C2 | |
| US9872494B2 | United States of America | B2 | |
| EP3092900B1 | European Patent Office (EPO) | B1 | |
| EP3103333B1 | European Patent Office (EPO) | B1 | |
| EP3103341B1 | European Patent Office (EPO) | B1 | |
| EP3103340B1 | European Patent Office (EPO) | B1 | |
| CN104824034B | China | B | |
| PT3092900T | Portugal | T | |
| PT3103333T | Portugal | T | |
| PT3103341T | Portugal | T | |
| DK3103341T3 | Denmark | T3 | |
| DK3092900T3 | Denmark | T3 | |
| DK3103333T3 | Denmark | T3 | |
| CN104824043B | China | B | |
| PT3103340T | Portugal | T | |
| DK3103340T3 | Denmark | T3 | |
| TR201808354T4 | Türkiye | T4 | |
| US2018206493A1 | United States of America | A1 | |
| CN104957174B | China | B | |
| PL3092900T3 | Poland | T3 | |
| PL3103333T3This record | Poland | T3 | |
| PL3103341T3 | Poland | T3 | |
| PL3103340T3 | Poland | T3 | |
| KR101894361B1 | Republic of Korea | B1 | |
| KR20180099924A | Republic of Korea | A | |
| CN104957175B | China | B | |
| CN104824036B | China | B | |
| CN104938522B | China | B | |
| BR112013013402B1 | Brazil | B1 | |
| CN105594749B | China | B | |
| EP3103336B1 | European Patent Office (EPO) | B1 | |
| EP3103337B1 | European Patent Office (EPO) | B1 | |
| EP3103339B1 | European Patent Office (EPO) | B1 | |
| EP3103342B1 | European Patent Office (EPO) | B1 | |
| EP3103343B1 | European Patent Office (EPO) | B1 | |
| CN104886081B | China | B | |
| BR122018003196B1 | Brazil | B1 | |
| BR122018003205B1 | Brazil | B1 | |
| BR122018003206B1 | Brazil | B1 | |
| PT3103336T | Portugal | T | |
| PT3103339T | Portugal | T | |
| PT3103342T | Portugal | T | |
| PT3103343T | Portugal | T | |
| PT3103337T | Portugal | T | |
| CN105638738B | China | B |
Numbers
- Publication
- 3103333
- Publication, DOCDB
- 3103333
- Publication, EPODOC
- PL3103333T
- Application
- 16173007
- Application, DOCDB
- 16173007
- Application, EPODOC
- PL20160173007T
Titles2
- English
- AGENT COMBINATIONS COMPRISING FLUOPYRAM AND OTHER IMICYAFOS
- Polish
- Kombinacje substancji aktywnych zawierające fluopiram i imicyjafos
Classification
- CPC, 12
- A01N43/40
- A01N31/08
- A01N43/28
- A01N57/32
- A01N2300/00
- A01N43/78
- A01N43/90
- A01N53/00
- A01N63/00
- A01N63/30
- A01N65/12
- A01N65/00
- IPC, 4
- A01N43 40
- A01N57 32
- A01P5 00
- A01P7 04