Stable liquid interferon formulations
Abstract
Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3 % and 5 % by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.
Term
No projected expiry on record.
- Priority
- Filed
- Published
- Today
80 members in 29 offices
Priority claims8
| Document | Office | Kind | Date |
|---|---|---|---|
| 3435396 | United States of America | P | |
| 3435396 | United States of America | P | |
| 9723817 | United States of America | W | |
| 9723817 | United States of America | W | |
| 3435396 | – | – | – |
| 9723817 | – | – | – |
| US19960034353P | – | – | – |
| WO1997US23817 | – | – | – |
Members80
| Document | Office | Kind | |
|---|---|---|---|
| CA2275890A1 | Canada | A1 | |
| WO9828007A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AU5619198A | Australia | A | |
| IS5087A | Iceland | A | |
| NO993121D0 | Norway | D0 | |
| NO993121LThis record | Norway | L | |
| EP0948358A1 | European Patent Office (EPO) | A1 | |
| CZ228299A3 | Czechia | A3 | |
| TR199901968T2 | Türkiye | T2 | |
| SK85899A3 | Slovakia | A3 | |
| CN1245434A | China | A | |
| EA199900597A1 | Eurasian Patent Organization (EAPO) | A1 | |
| PL334365A1 | Poland | A1 | |
| EE9900313A | Estonia | A | |
| BG103594A | Bulgaria | A | |
| BR9714434A | Brazil | A | |
| IL130524D0 | Israel | D0 | |
| HU0000829A2 | Hungary | A2 | |
| HUP0000829A2 | Hungary | A2 | |
| HK1025040A1 | Hong Kong, China | A1 | |
| KR20000069664A | Republic of Korea | A | |
| AU738362B2 | Australia | B2 | |
| NZ336548A | New Zealand | A | |
| JP2001519770A | Japan | A | |
| HU0000829A3 | Hungary | A3 | |
| HUP0000829A3 | Hungary | A3 | |
| EA002754B1 | Eurasian Patent Organization (EAPO) | B1 | |
| NZ512792A | New Zealand | A | |
| EE200300127A | Estonia | A | |
| US2003190307A1 | United States of America | A1 | |
| EE04223B1 | Estonia | B1 | |
| EE04266B1 | Estonia | B1 | |
| EP0948358B1 | European Patent Office (EPO) | B1 | |
| AT270899T | Austria | T | |
| ATE270899T1 | Austria | T1 | |
| DE69729880D1 | Germany | D1 | |
| PT948358E | Portugal | E | |
| DK0948358T3 | Denmark | T3 | |
| ES2224290T3 | Spain | T3 | |
| SI0948358T1 | Slovenia | T1 | |
| HU224222B1 | Hungary | B1 | |
| DE69729880T2 | Germany | T2 | |
| IL130524A | Israel | A | |
| CN1222315C | China | C | |
| IS2070B | Iceland | B | |
| CN1733296A | China | A | |
| SK284989B6 | Slovakia | B6 | |
| HK1092048A1 | Hong Kong, China | A1 | |
| PL193447B1 | Poland | B1 | |
| KR20070052363A | Republic of Korea | A | |
| BG109523A | Bulgaria | A | |
| BG65171B1 | Bulgaria | B1 | |
| JP2007204501A | Japan | A | |
| US2008044381A1 | United States of America | A1 | |
| US2008050338A1 | United States of America | A1 | |
| US2008050339A1 | United States of America | A1 | |
| BG65418B1 | Bulgaria | B1 | |
| CZ300636B6 | Czechia | B6 | |
| NO327844B1 | Norway | B1 | |
| CN1733296B | China | B | |
| US2010239531A1 | United States of America | A1 | |
| JP2011068694A | Japan | A | |
| KR101042660B1 | Republic of Korea | B1 | |
| CA2275890C | Canada | C | |
| EP0948358B2 | European Patent Office (EPO) | B2 | |
| JP2012006979A | Japan | A | |
| JP4878664B2 | Japan | B2 | |
| ES2224290T5 | Spain | T5 | |
| DK0948358T4 | Denmark | T4 | |
| SI0948358T2 | Slovenia | T2 | |
| DE69729880T3 | Germany | T3 | |
| US8512691B2 | United States of America | B2 | |
| US8512692B2 | United States of America | B2 | |
| US2013302281A1 | United States of America | A1 | |
| JP2014098029A | Japan | A | |
| US8932574B2 | United States of America | B2 | |
| US2015093359A1 | United States of America | A1 | |
| JP5851695B2 | Japan | B2 | |
| MX337876B | Mexico | B | |
| US9522174B2 | United States of America | B2 |
2 legal events, as the office reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | |
|---|---|---|
| Patent expiredExpiredMK1K | MK1K | |
| Change of the owner's name or address (par. 44 patent law, par. patentforskriften)CHAD | CHAD |
Numbers
- Publication
- 19993121
- Publication, DOCDB
- 993121
- Publication, EPODOC
- NO993121L
- Application
- 993121
- Application, DOCDB
- 993121
- Application, EPODOC
- NO19990003121
Titles2
- Norwegian
- Stabile flytende interferon-formuleringer
- English
- Stable liquid interferon formulations
Classification
- CPC, 11
- A61K47/183
- A61K47/18
- A61K9/0019
- A61K38/215
- A61P25/28
- A61P31/12
- A61P31/18
- A61P35/00
- A61P35/04
- A61P37/02
- A61P43/00
- IPC, 4
- A61K38 21
- A61K9 08
- A61K47 18
- A61P43 00