Novel derivatives of flavones, xanthones and coumarins
Abstract
Compounds having the formula (I)or a pharmaceutically acceptable salt or solvate thereof wherein Z can represent the formula (1A) or (1B).The compounds possess antiproliferative activity and are useful as modulators of multiple drug resistance in cancer chemotherapy. The compounds may also be useful for the manufacture of a medicament for the treatment or prevention of neoplasms, menopausal disorders and osteoporosis.
Term
No projected expiry on record.
- Priority
- Filed
- Published
- Today
1 claim: 1 independent, 0 dependent
- 1Z-OCH2-C = CCH2NRR1 Z-OCH2-C=CCH2NRR1
11 paragraphs, as filed
(21) Application No (22) Entry Day (24) Running Day (41) Alm. avail.
<td> 20021050 2002.03.01</td><td>(86) Int. Entry date and application number</td><td>2000.08.28, PCT / EP00 / 08365</td>
<td> 2000.08.28</td><td>(85) Continuation Day</td><td> 2002.03.01</td>
<td> 2002.05.03</td><td>(30) Priority</td><td>1999.09.03, GB, 9920912</td>
(71) Seeking (72) Inventor (74) Proxy
Indena SpA, Viale Ortles, 12.1-20139 Milan, IT
Ezio Bombardelli, Milan, IT
Piero Valenti, Bologna, IT
JK Thorsens Patentburéau AS, 0134 Oslo (54) Name (57) Summary
New derivatives of flavones, xanthones and coumarins
Novel compounds having formula (I): Z-OCH 2 -C 2 CCH 2 NRR<sup>1</sup> (I) or a pharmaceutically acceptable salt or solvate thereof wherein Z may represent formulas (IA) or (IB). The compounds possess antiproliferative activity and are useful as modulators of multiple drug resistance in cancer chemotherapy. The compounds may also be useful in the manufacture of a medicament for the treatment or prevention of neoplasms, menopausal disorders and osteoporosis.
39 members in 22 offices
Priority claims8
| Document | Office | Kind | Date |
|---|---|---|---|
| 9920912 | United Kingdom | A | |
| 9920912 | United Kingdom | A | |
| 0008365 | European Patent Office (EPO) | W | |
| 0008365 | European Patent Office (EPO) | W | |
| 0008365 | – | – | – |
| 9920912 | – | – | – |
| GB19990020912 | – | – | – |
| WO2000EP08365 | – | – | – |
Members39
| Document | Office | Kind | |
|---|---|---|---|
| GB9920912D0 | United Kingdom | D0 | |
| CA2382129A1 | Canada | A1 | |
| WO0117985A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AU7000000A | Australia | A | |
| NO20021050D0 | Norway | D0 | |
| KR20020030801A | Republic of Korea | A | |
| NO20021050LThis record | Norway | L | |
| CZ2002785A3 | Czechia | A3 | |
| EP1212312A1 | European Patent Office (EPO) | A1 | |
| HK1043368A1 | Hong Kong, China | A1 | |
| CN1371371A | China | A | |
| HU0202578A2 | Hungary | A2 | |
| HUP0202578A2 | Hungary | A2 | |
| US2002183318A1 | United States of America | A1 | |
| JP2003508524A | Japan | A | |
| EP1212312B1 | European Patent Office (EPO) | B1 | |
| AT236147T | Austria | T | |
| ATE236147T1 | Austria | T1 | |
| DE60001974D1 | Germany | D1 | |
| DK1212312T3 | Denmark | T3 | |
| US6608089B2 | United States of America | B2 | |
| PT1212312E | Portugal | E | |
| SK3092002A3 | Slovakia | A3 | |
| ES2195933T3 | Spain | T3 | |
| SI1212312T1 | Slovenia | T1 | |
| DE60001974T2 | Germany | T2 | |
| PL356699A1 | Poland | A1 | |
| AU775790B2 | Australia | B2 | |
| HU0202578A3 | Hungary | A3 | |
| HUP0202578A3 | Hungary | A3 | |
| RU2252221C2 | Russian Federation | C2 | |
| CN1229370C | China | C | |
| KR100819575B1 | Republic of Korea | B1 | |
| SK286402B6 | Slovakia | B6 | |
| CZ300939B6 | Czechia | B6 | |
| NO327911B1 | Norway | B1 | |
| CA2382129C | Canada | C | |
| JP4782337B2 | Japan | B2 | |
| PL211887B1 | Poland | B1 |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Lapsed by not paying the annual feesLapsedMM1K | MM1K |
Numbers
- Publication, DOCDB
- 20021050
- Publication, EPODOC
- NO20021050L
- Application
- 1050
- Application, DOCDB
- 20021050
- Application, EPODOC
- NO20020001050
Titles2
- Norwegian
- Nye derivater av flavoner, xantoner og kumariner
- English
- New derivatives of flavones, xanthones and coumarins
Classification
- CPC, 14
- C07D311/86
- A61K31/35
- A61K31/37
- A61K31/44
- A61K31/52
- A61K31/535
- C07D311/16
- C07D311/30
- C07D311/36
- A61P15/00
- A61P15/12
- A61P19/10
- A61P35/00
- A61P43/00
- IPC, 29
- A61K31 165
- A61K31 337
- C07D311 18
- A61K31 35
- A61K31 352
- A61K31 37
- A61K31 4025
- A61K31 44
- A61K31 453
- A61K31 485
- A61K31 496
- A61K31 497
- A61K31 52
- A61K31 535
- A61K31 5377
- A61K31 704
- A61K38 00
- A61K45 00
- A61P15 00
- A61P15 12
- A61P19 10
- A61P35 00
- A61P43 00
- C07D311 16
- C07D311 30
- C07D311 36
- C07D311 86
- C07D405 12
- C07D413 12