Reticulated enzym crystals and application thereof in an extracorporal device, biosensor and for obtaining the selected product

The invention refers to the reticulated enzym crystals, manifesting the protease resistance.The present invention forsees utilization of the reticulated enzym crystals in an extracorporal device, biosensors for analyte detection and as enzymatic catalyst for obtaining the selected product.Summary of the invention consists in, that the enzyms crystalls are reticulated by the polyfunctional reticulating agent, and the reticulated crystals manifest resistance to the exogenic proteolyse so, that the mentioned reticulated crystals retain at least 91% of initial activity thereof after the incubation during 3 hours in presence of pronase (PronaseTM) when in the same conditions the non-reticulated soluble form of the crystalizing enzym looses at least 94% of its initial activity.The result of the invention consists in, that into the enzyms crystals there are introduced intermolecular transversal linkages which considerably improve the properties of such crystals, what promotes wide application thereof in medicine, industry and long store at keeping activity thereof.