Heteropolycyclic compounds, pharmaceutical compositions containing them and their use as metabotropic glutamate receptor antagonists
Abstract
The invention relates to metabotropic glutamate receptor antagonist compounds that can be used to treat neurological and psychiatric diseases and disorders. In the compounds of formula (II) according to the invention, X, Y and Z are independently a nitrogen, oxygen, sulfur or carbon atom or a carbonyl group, Ar1 and Ar2 are independently an optionally substituted heterocyclic or condensed heterocyclic group chosen from among nitrogen, oxygen and sulfur atoms Contains 1-4 heteroatoms, or a substituted aromatic group selected from the following group: phenyl, benzyl, 1-naphthyl, 2-naphthyl, fluorenyl, anthrenyl, indenyl, phenanthrenyl, benzonaphthenyl. HE

Term
No projected expiry on record.
- Priority
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- Today
6 sheets
Sheet 1 Sheet 2 Sheet 3 Sheet 4 Sheet 5 Sheet 6
95 members in 31 offices
Priority claims2
| Document | Office | Kind | Date |
|---|---|---|---|
| 14946499 | United States of America | P | |
| 0022618 | United States of America | W |
Members95
| Document | Office | Kind | |
|---|---|---|---|
| CA2381975A1 | Canada | A1 | |
| WO0112627A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AU6782400A | Australia | A | |
| IS6275A | Iceland | A | |
| NO20020823D0 | Norway | D0 | |
| NO20020823L | Norway | L | |
| KR20020038731A | Republic of Korea | A | |
| EP1210344A1 | European Patent Office (EPO) | A1 | |
| CZ2002599A3 | Czechia | A3 | |
| SK2512002A3 | Slovakia | A3 | |
| BR0013427A | Brazil | A | |
| CA2438991A1 | Canada | A1 | |
| WO02068417A2 | World Intellectual Property Organization (WIPO) | A2 | |
| IL148157A0 | Israel | A0 | |
| IL148157D0 | Israel | D0 | |
| CN1379775A | China | A | |
| WO02068417A3 | World Intellectual Property Organization (WIPO) | A3 | |
| HU0202757A2 | Hungary | A2 | |
| HUP0202757A2This record | Hungary | A2 | |
| BG106493A | Bulgaria | A | |
| JP2003507378A | Japan | A | |
| HK1047929A | Hong Kong, China | A | |
| HK1047929A1 | Hong Kong, China | A1 | |
| US2003055085A1 | United States of America | A1 | |
| EE200200079A | Estonia | A | |
| ZA200201358B | South Africa | B | |
| IS6922A | Iceland | A | |
| NO20033711D0 | Norway | D0 | |
| NO20033711L | Norway | L | |
| KR20030088434A | Republic of Korea | A | |
| PL353825A1 | Poland | A1 | |
| US6660753B2 | United States of America | B2 | |
| EP1379525A2 | European Patent Office (EPO) | A2 | |
| NZ517221A | New Zealand | A | |
| MXPA02001764A | Mexico | A | |
| IL157491A0 | Israel | A0 | |
| IL157491D0 | Israel | D0 | |
| MXPA03007513A | Mexico | A | |
| HK1060559A1 | Hong Kong, China | A1 | |
| BR0207390A | Brazil | A | |
| ZA200306493B | South Africa | B | |
| JP2004536037A | Japan | A | |
| AU780191B2 | Australia | B2 | |
| RU2003128535A | Russian Federation | A | |
| PL369598A1 | Poland | A1 | |
| US2005154027A1 | United States of America | A1 | |
| CN1649865A | China | A | |
| EP1582519A2 | European Patent Office (EPO) | A2 | |
| EP1210344B1 | European Patent Office (EPO) | B1 | |
| AT307129T | Austria | T | |
| ATE307129T1 | Austria | T1 | |
| UA74419C2 | Ukraine | C2 | |
| EP1582519A3 | European Patent Office (EPO) | A3 | |
| DE60023318D1 | Germany | D1 | |
| DK1210344T3 | Denmark | T3 | |
| HU0202757A3 | Hungary | A3 | |
| HUP0202757A3 | Hungary | A3 | |
| ES2250177T3 | Spain | T3 | |
| JP2006143746A | Japan | A | |
| UA75871C2 | Ukraine | C2 | |
| JP3790472B2 | Japan | B2 | |
| EP1679313A2 | European Patent Office (EPO) | A2 | |
| JP2006182789A | Japan | A | |
| DE60023318T2 | Germany | T2 | |
| EP1679313A3 | European Patent Office (EPO) | A3 | |
| US2006189661A1 | United States of America | A1 | |
| US7112595B2 | United States of America | B2 | |
| NO322460B1 | Norway | B1 | |
| CN1853630A | China | A | |
| NZ527691A | New Zealand | A | |
| RU2296127C2 | Russian Federation | C2 | |
| CN1313465C | China | C | |
| IL148157A | Israel | A | |
| CN1332959C | China | C | |
| RU2296127C9 | Russian Federation | C9 | |
| AU2002306517B2 | Australia | B2 | |
| EP1379525B1 | European Patent Office (EPO) | B1 | |
| AT375340T | Austria | T | |
| ATE375340T1 | Austria | T1 | |
| DE60222872D1 | Germany | D1 | |
| PT1379525E | Portugal | E | |
| DK1379525T3 | Denmark | T3 | |
| SI1379525T1 | Slovenia | T1 | |
| ES2292830T3 | Spain | T3 | |
| RU2319701C2 | Russian Federation | C2 | |
| KR100838447B1 | Republic of Korea | B1 | |
| DE60222872T2 | Germany | T2 | |
| NO326105B1 | Norway | B1 | |
| KR100875222B1 | Republic of Korea | B1 | |
| BG65586B1 | Bulgaria | B1 | |
| IS2564B | Iceland | B | |
| CY1105253T1 | Cyprus | T1 | |
| JP4519404B2 | Japan | B2 | |
| CA2438991C | Canada | C | |
| CY1107005T1 | Cyprus | T1 |
2 legal events, as the office reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | |
|---|---|---|
| Lapse of provisional protection due to non-payment of feesLapsedFD9A | FD9A | |
| Succession in titleGB9A | GB9A |
Numbers
- Application
- 202757
Titles2
- English
- HETEROPOLYCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
- Hungarian
- Metabotróp glutamát receptor antagonista heteropoliciklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és a vegyületek alkalmazása
Classification
- CPC, 17
- C07D401/04
- C07D413/04
- A61P25/00
- A61P25/04
- A61P25/06
- A61P25/08
- A61P25/14
- A61P25/16
- A61P25/18
- A61P25/24
- A61P25/28
- A61P29/00
- A61P29/02
- A61P3/08
- A61P43/00
- A61P9/00
- A61P9/10
- IPC, 19
- A61K
- A61K31 4245
- A61K31 4439
- A61K31 4709
- A61K31 4725
- A61K31 497
- A61P
- A61P9 10
- A61P25 00
- A61P25 06
- A61P25 08
- A61P25 14
- A61P25 16
- A61P25 28
- A61P29 00
- C07D
- C07D401 04
- C07D403 04
- C07D413 04