Modified human G-CSF.

A MODIFIED POLYPEPTIC PRESENTING A STIMULATING FACTOR ACTIVITY OF THE HUMAN GRANULOCYTIC COLONY (HG - CSF) INCLUDES A POLYPEPTIDE THAT HAS HG - CSF ACTIVITY WITH AT LEAST ONE AMINO GROUP REPLACED WITH A GROUP RESPONDING TO THE FORMULA 1 (FORMULA I) IT IS AN ALKYL OR ALCANOYL GROUP, N IS A WHOLE POSITIVE NUMBER THAT MAY VARY OPTIONALLY; X ES 0, NH OS; R2 IS (FORMULA II): (WHERE R3 IS - OH, CL, O - (CH2CH2O) N - R1, WHERE R1 AND N RESPOND TO THE ABOVE DEFINITION, AND MAY BE Z - (CH2) PCO, WHERE Z IS O, SO NH AND P IS A VARIABLE POSITIVE INTEGER OPTIONALLY, OR NOT BEING PRESENT), O (CO) M - (CH2) L CO, WHERE M IS 0 OR 1, L IS AN INTEGRELY OPTIONALLY VARIABLE POSITIVE, WHICH MAY CONTRIBUTE WITH A GREATER INCREASE EFFECT IN PERIPHERAL LEUKOCYTES (GRANULOCYTES ) WITH GREATER STABILITY AND TIME OF REMAINING IN THE BLOOD AND, AS SUCH, IT CAN BE USEFULLY USED IN CLINICAL MEDICINE.