Barrel for female syringe, syringe kit and syringe connection method

Technical Field

0001The present invention relates to a syringe kit, and a syringe connection method.

Background Art

0002A syringe kit for mixing two medicinal fluids configured to mix a medicinal chemical in one barrel and a medicinal chemical in the other barrel is disclosed in, for example, <patcit id="pcit0001" dnum="JP2013132349A"><text>JP 2013-132349 A</text></patcit>. This syringe kit includes: a first barrel (female syringe barrel) having a connecting tube portion provided with an inner tapered surface on an inner circumference and a male screw on an outer circumference; and a second barrel (male syringe barrel) having a nozzle portion, which has an outer tapered surface on an outer circumference and is fittable to the inner tapered surface on the inner circumference of the connecting tube portion, and a screw tube portion provided with a female screw, screwable with the male screw, on an inner circumference. In the syringe kit, the connecting tube portion of the first barrel and the screw tube portion of the second barrel are connected by screwing in order to mix a medicinal chemical in the first barrel and a medicinal chemical in the second barrel.

0003<patcit id="pcit0002" dnum="EP0805930B1"><text>EP 0 805 930 B1</text></patcit> discloses a syringe kit having the features of the preamble of claim 1.

0004<patcit id="pcit0003" dnum="US2008140020A1"><text>US 2008/140020 A1</text></patcit> discloses lockable enteral feeding adapters. In particular, a female adapter has a female tapered cavity having a circular sidewall, a tapered inner surface and an external surface. The female tapered cavity has an external opening at a proximal end thereof that does not form a liquid-tight connection with a standard male Luer conical fitting. One or more threads are disposed on the external surface of the tapered cavity. A male adapter has a male tapered cone that is sized to mate with the female tapered cavity. The male tapered cone is too large to form an effective connection with a standard female Luer conical fitting. An internally threaded locking ring is mounted around the male tapered cone. Rotation of the locking ring relative to the one or more threads locks the male adapter to the corresponding female adapter to prevent unintentional disengagement of the male and female adapters.

Summary of Invention

0005In the syringe kit of <patcit id="pcit0004" dnum="JP2013132349A"><text>JP 2013-132349 A</text></patcit> described above, both of a screwing portion of the connecting tube portion of the first barrel, and a screwing portion of the screw tube portion of the second barrel have a screw shape, and thus, excessive screwing is possible. Therefore, there is a problem that the tapered surfaces excessively fit together, and the connecting tube portion (mouth) of the first barrel is damaged or deformed, so that the liquid tightness between the nozzle and the cylindrical portion deteriorates. In addition, there is a problem that a distal end portion of either the first barrel or the second barrel is twisted to be damaged or deformed, so that the liquid tightness between the nozzle and the cylindrical portion deteriorates.

0006The present invention has been made in view of such problems, and an object thereof is to provide a syringe kit, and a syringe connection method capable of preventing damage and deformation of a female syringe barrel or a male syringe barrel caused by an excessive torque and preventing deterioration in liquid tightness between a nozzle and a cylindrical portion when screwing the female syringe barrel and the male syringe barrel.

0007The above object is solved by a syringe kit having the features of claim 1. A syringe connection method is stated in claim 5. Further developments are stated in the dependent claims.

0008In particular, the syringe kit of claim 1 includes: a male syringe having a male syringe barrel that includes a nozzle configured as a male luer and a lock adapter provided with a screw; and a female syringe having a female syringe barrel that includes a cylindrical portion configured as a female luer to which the nozzle is fittable, two protrusions which protrude from an outer circumferential surface of the cylindrical portion and are screwable with the screw of the lock adapter, and a female barrel body connected to the cylindrical portion. Each of the two protrusions has an inclined surface. When the screw and the two protrusions are screwed, the protrusions having the inclined surface advance over a screw thread of the lock adapter by a torque smaller than a torque at which the female syringe breaks when the female syringe is screwed with a convex reference conical fitting for a stress crack test specified in ISO 594-2.

0009According to the syringe kit of the present invention adopting the above configuration, when the male syringe and the female syringe are connected by screwing, excessive tightening can be prevented, damage and deformation of the cylindrical portion of the female syringe can be prevented, and deterioration in liquid tightness between the nozzle and the cylindrical portion can be prevented.

0010In the above syringe kit, both the male syringe barrel and the female syringe barrel may be made of a cyclic polyolefin.

0011Since the cyclic polyolefin has high rigidity and toughness, when the protrusion advances over the screw thread of the lock adapter, the protrusion and the cylindrical portion are less likely to be deformed, and the nozzle is less likely to be deformed, and thus, the liquid tightness between the nozzle and the cylindrical portion is kept favorable.

0012In the above syringe kit, both of an outer diameter of the male barrel body and an outer diameter of the female barrel body may be 6.7 mm or more, and both of an axial length of the male barrel body and an axial length of the female barrel body may be 35 mm or more.

0013In general, a barrel for a syringe having a barrel body of such external dimensions is likely to be subjected to a strong torque during the screwing, and is likely to be broken or deformed. According to this invention, however, it is possible to prevent the damage and deformation of the cylindrical portion and to effectively prevent the deterioration in liquid tightness between the nozzle and the cylindrical portion, which is advantageous.

0014In the above syringe kit, an inner diameter of the screw of the lock adapter may be 6.8 to 7.2 mm, the cylindrical portion may have an abutment portion provided at a position closer to a proximal end than the two protrusions on the outer circumferential portion of the cylindrical portion, and the abutment portion may have an outer diameter of 6.4 to 6.8 mm. When the two protrusions of the cylindrical portion are screwed with the screw of the lock adapter of the male syringe, the abutment portion may abut on an inner circumferential surface of the screw of the lock adapter so as to suppress the inclination of the axis of the cylindrical portion with respect to the axis of the lock adapter.

0015With this configuration, the inclination of the axis is suppressed by the abutment portion when the two protrusions of the cylindrical portion are screwed with the screw of the lock adapter of the male syringe, and thus, it is possible to prevent the breakage of the cylindrical portion due to uneven stress in the circumferential direction.

0016Further, the method of claim 5 is a syringe connection method for connecting a male syringe and a female syringe by screwing. The male syringe has a male syringe barrel that includes: a nozzle configured as a male luer; and a lock adapter provided with a screw. The female syringe has a female syringe barrel that includes: a cylindrical portion configured as a female luer to which the nozzle is fittable; and two protrusions screwable with the screw of the lock adapter. Each of the two protrusions has an inclined surface. When the screw and the protrusions are screwed, the protrusions having the inclined surface advance over a screw thread of the lock adapter by a predetermined torque, and a click feeling is generated along with the advancement.

0017As a result, it is possible to prevent the female syringe barrel or the male syringe barrel from being damaged or deformed due to an excessive torque during the screwing and to prevent deterioration in liquid tightness between the nozzle and the cylindrical portion, and a user who has performed the screwing operation can easily know that the screwing between the protrusions and the screw has been completed based on the generated click feeling.

0018In the above syringe connection method, the cylindrical portion may have an abutment portion provided at a position closer to a proximal end than the two protrusions on the outer circumferential portion of the cylindrical portion, and the abutment portion may abut on an inner circumferential surface of the lock adapter to suppress an inclination of an axis of the cylindrical portion with respect to an axis of the lock adapter when the screw and the two protrusions are screwed.

0019As a result, the inclination of the axis is suppressed by the abutment portion when the two protrusions of the cylindrical portion are screwed with the screw of the lock adapter of the male syringe, and thus, it is possible to prevent the breakage of the cylindrical portion due to uneven stress in the circumferential direction.

0020According to the syringe kit, and the syringe connection method of the present invention, it is possible to prevent the female syringe barrel or the male syringe barrel from being damaged or deformed due to the excessive torque during the screwing, and to prevent the deterioration in liquid tightness between the nozzle and the cylindrical portion.

Brief Description of Drawings

0021<ul id="ul0001" list-style="none" compact="compact"><li><figref idref="f0001">Fig. 1</figref> is a perspective view of a syringe kit according to an embodiment of the present invention.</li><li><figref idref="f0002">Fig. 2</figref> is a cross-sectional view of a male syringe barrel.</li><li><figref idref="f0003">Fig. 3</figref> is a cross-sectional view of a female syringe barrel.</li><li><figref idref="f0004">Fig. 4</figref> is a perspective view of a distal end portion of the female syringe barrel.</li><li><figref idref="f0005">Fig. 5</figref> is a side view of the distal end portion of the female syringe barrel.</li><li><figref idref="f0006">Fig. 6</figref> is a perspective view illustrating a state where a male syringe and a female syringe are connected.</li><li><figref idref="f0007">Fig. 7</figref> is a schematic view illustrating a state where a protrusion of the female syringe advances over a screw of the male syringe.</li><li><figref idref="f0008">Fig. 8</figref> is a perspective view of a distal end portion of a female syringe barrel according to a first modification.</li><li><figref idref="f0009">Fig. 9</figref> is a side view of the distal end portion of the female syringe barrel according to the first modification.</li><li><figref idref="f0010">Fig. 10</figref> is a cross-sectional view of a state where the female syringe barrel and a male syringe barrel according to a first modification are connected.</li><li><figref idref="f0011">Fig. 11</figref> is a perspective view of a female syringe barrel according to a second modification.</li><li><figref idref="f0012">Fig. 12A</figref> is a cross-sectional view illustrating a state where the female syringe barrel and a male syringe barrel according to a second modification are connected, and <figref idref="f0012">Fig. 12B</figref> is a cross-sectional view taken along the line XIIB-XIIB in <figref idref="f0012">Fig. 12A</figref>.</li><li><figref idref="f0013">Fig. 13</figref> is a schematic view illustrating a state where a protrusion and a proximal-end-side protrusion of the female syringe barrel according to the second modification advance over screws of the male syringe.</li><li><figref idref="f0014">Fig. 14</figref> is a perspective view of a female syringe barrel according to a third modification.</li><li><figref idref="f0015">Fig. 15</figref> is a cross-sectional view of a state where the female syringe barrel and a male syringe barrel according to a third modification are connected.</li></ul>

Description of Embodiments

0022Hereinafter, a female syringe barrel, a syringe kit, and a syringe connection method will be described with reference to the accompanying drawings.

0023A syringe kit 10 according to the present embodiment illustrated in <figref idref="f0001">Fig. 1</figref> is a mixing kit configured to mix a filling in one barrel and a filling in the other barrel. The syringe kit 10 includes a male syringe 12 and a female syringe 14 that can be screw-connected to each other. Both the male syringe 12 and the female syringe 14 are configured as prefilled syringes which are pre-filled with contents such as medicines.

0024Note that a side of the male syringe 12 that is connected to the female syringe 14 or a direction thereof is referred to as a "distal end portion" or a "distal end direction", and the opposite side or the opposite direction is referred to as a "proximal end portion" or a "proximal end direction" in the following description. In addition, a side of the female syringe 14 that is connected to the male syringe 12 or a direction thereof is referred to as a "distal end portion" or a "distal end direction", and the opposite side or the opposite direction is referred to as a "proximal end portion" or a "proximal end direction".

0025The male syringe 12 includes: a male syringe barrel 16 formed of a hollow body; a gasket 18 slidably inserted into the male syringe barrel 16; a pusher 20 connected to the gasket 18; and a medicine M filling a barrel chamber 17 formed by the male syringe barrel 16 and the gasket 18. Hereinafter, the "male syringe barrel 16" is abbreviated as "male barrel 16".

0026As illustrated in <figref idref="f0002">Fig. 2</figref>, the male barrel 16 has: a barrel body 22 (male barrel body) having a substantially cylindrical shape and a proximal end opening 22a formed at a proximal end; a nozzle 24 provided at a distal end of the barrel body 22; a lock adapter 26 provided outside the nozzle 24; and a flange 29 formed to protrude radially outward from the proximal end of the barrel body 22; The barrel body 22, the nozzle 24, the lock adapter 26, and the flange 29 are integrally formed.

0027An outer diameter D1 of the barrel body 22 is not particularly limited, but is preferably 6.7 mm or more. In addition, an axial length L1 of the barrel body 22 is not particularly limited, but is preferably 35 mm or more, and more preferably 47 mm or more. When the outer diameter D1 and the axial length L1 of the barrel body 22 are set in this manner, screwing is easily performed by gripping the barrel body 22 at the time of connecting the male syringe 12 with the female syringe 14.

0028The nozzle 24 extends in the distal end direction while being reduced in diameter from the center of the distal end of the barrel body 22 to the barrel body 22. The nozzle 24 has a passage 24b penetrating in the axial direction and communicating with an inner cavity (the barrel chamber 17) of the barrel body 22.

0029The nozzle 24 has a circular cross-sectional outer shape and is configured as a male luer having a tapered outer circumferential surface 24a whose outer diameter decreases toward the distal end direction. The nozzle 24 can be fitted to a cylindrical portion 38 (female luer), which will be described later, of the female syringe 14. The nozzle 24 protrudes in the distal end direction from a distal end surface of the lock adapter 26.

0030Note that a cap (not illustrated) is mounted on the nozzle 24 in an initial state of the male syringe 12 illustrated in <figref idref="f0001">Fig. 1</figref>, and a distal end opening 24c of the nozzle 24 is sealed by this cap. The cap is detached from the nozzle 24 at the time of using the male syringe 12 (at the time of using the syringe kit 10).

0031In <figref idref="f0002">Fig. 2</figref>, the lock adapter 26 is formed in a substantially hollow cylindrical shape that extends in the distal end direction from the distal end of the barrel body 22 and surrounds the nozzle 24 concentrically. An annular recess 26a that is open in the distal end direction is formed between an inner circumferential portion of the lock adapter 26 and an outer circumferential portion of the nozzle 24. A screw 28 is formed on an inner circumferential surface of the lock adapter 26. The screw 28 has a screw thread 28a protruding inward from the inner circumferential surface of the lock adapter 26.

0032In <figref idref="f0001">Fig. 1</figref>, the gasket 18 is inserted into the barrel body 22 via the proximal end opening 22a that is open at the proximal end of the barrel body 22. The proximal end side of the barrel body 22 is sealed by the gasket 18 in a liquid-tight manner. The gasket 18 is made of an elastic material such as a rubber material. The gasket 18 has an outer circumferential portion being in liquid-tight contact with an inner circumferential surface of the barrel body 22 and is arranged to be slidable inside the barrel body 22.

0033The gasket 18 is connected to a distal end portion of the pusher 20. When a user presses the pusher 20 in the axial direction (distal end direction or proximal end direction), the gasket 18 slides in the axial direction inside the barrel body 22. Note that the pusher 20 may be connected to the gasket 18 at the time of using the male syringe 12.

0034The medicine M may be any medicine such as a powdered medicine, a lyophilized medicine, a solid medicine, and a liquid medicine as long as being dissolved, diluted, and mixed by a medical liquid ML (specifically, a dissolving solution such as a physiological saline) filling the inside of the female syringe 14. Examples of the medicine M include protein preparations, peptide preparations, antitumor agents, vitamins (multivitamins), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, analgesics, cardiotonic agents, intravenous injection anesthetics, medical narcotics, anti-parkinsonian agents, ulcer treatment agents, corticosteroids, arrhythmic agents, and the like.

0035The female syringe 14 includes: a female syringe barrel 30 formed of a hollow body; a gasket 32 slidably inserted into the female syringe barrel 30; a pusher 34 connected to the gasket 32; and the medical liquid ML filling a barrel chamber 37 formed by the female syringe barrel 30 and the gasket 32. Hereinafter, the "female syringe barrel 30" is abbreviated as "female barrel 30".

0036As illustrated in <figref idref="f0003">Fig. 3</figref>, the female barrel 30 has: a barrel body 36 (female barrel body) having a substantially cylindrical shape and a proximal end opening 36a formed at a proximal end; a cylindrical portion 38 protruding in the distal end direction from a distal end of the barrel body 36; and a flange 40 formed to protrude radially outward from the proximal end of the barrel body 36. The barrel body 36, the cylindrical portion 38, and the flange 40 are integrally formed. Note that the cylindrical portion 38 is thinner than the barrel body 36 in <figref idref="f0003">Fig. 3</figref>, but the cylindrical portion 38 may have the same thickness as the barrel body 36 or may be thicker than the barrel body 36.

0037An outer diameter D2 of the barrel body 36 is not particularly limited, but is preferably 6.7 mm or more. In addition, an axial length L2 of the barrel body 36 is not particularly limited, but is preferably 35 mm or more, and more preferably 47 mm or more. When the outer diameter D2 and the axial length L2 of the barrel body 36 are set in this manner, screwing is easily performed by gripping the barrel body 36 at the time of connecting the female syringe 14 with the male syringe 12.

0038The cylindrical portion 38 extends in the distal end direction while being reduced in diameter from the center of the distal end of the barrel body 36 to the barrel body 36. The cylindrical portion 38 has a passage 38b penetrating in the axial direction and communicating with an inner cavity (the barrel chamber 37) of the barrel body 36. The cylindrical portion 38 is configured as a female luer having a tapered inner circumferential surface 38a whose outer diameter increases in the distal end direction.

0039As illustrated in <figref idref="f0004">Fig. 4</figref>, two protrusions 42 protruding to outer sides (radially outer sides), opposite to each other with respect to an axis (center line) of the cylindrical portion 38, are provided on an outer circumferential portion at the distal end of the cylindrical portion 38. The two protrusions 42 have the same shape and size. The two protrusions 42 can be screwed with the screw 28 (see <figref idref="f0002">Fig. 2</figref>) provided on the lock adapter 26 of the male barrel 16. Each of the protrusions 42 extends in an arc shape in the circumferential direction along an outer circumferential surface of the cylindrical portion 38.

0040In <figref idref="f0005">Fig. 5</figref>, a length Lp of the protrusion 42 along the radial direction of the cylindrical portion 38 is set to 35 to 65% of an outer diameter Dc of the cylindrical portion 38. Specifically, the length Lp of the protrusion 42 is set to 2.0 to 4.5 mm. Note that the length Lp of the protrusion 42 is an external dimension of a protruding end portion of the protrusion 42 in a direction perpendicular to an axis of the cylindrical portion 38 and perpendicular to a direction in which the protrusion 42 protrudes from the cylindrical portion 38 (see also <figref idref="f0004">Fig. 4</figref>) . A width W of the protrusion 42 along the axial direction of the cylindrical portion 38 is set to 1.0 to 1.5 mm.

0041An inclined surface 42a opposing a trailing flank of the screw 28 (see <figref idref="f0002">Fig. 2</figref>) of the above-described lock adapter 26 is provided at a proximal end portion of the protrusion 42 (an end portion of the protrusion 42 close to the barrel body 36). That is, the inclined surface 42a is inclined with respect to the circumferential direction of the cylindrical portion 38 to be substantially parallel to a spiral extending direction of the screw 28 when the protrusion 42 is screwed with the screw 28.

0042As illustrated in <figref idref="f0004">Figs. 4</figref> and <figref idref="f0005">5</figref>, a ring-shaped protruding portion 44 that protrudes outward from the distal end portion of the cylindrical portion 38 is integrally provided in the female barrel 30 according to the present embodiment. The ring-shaped protruding portion 44 extends in the circumferential direction along the outer circumferential surface of the cylindrical portion 38 with the axis of the cylindrical portion 38 as the center. The ring-shaped protruding portion 44 is continuous with the two protrusions 42. Specifically, the two protrusions 42 are integrally provided on an outer circumferential portion of the ring-shaped protruding portion 44. The two protrusions 42 protrude outward from the outer circumferential portion of the ring-shaped protruding portion 44. The proximal end portion of each of the protrusions 42 protrudes in the proximal end direction (toward the barrel body 36) from a proximal end surface of the ring-shaped protruding portion 44 (an end surface of the ring-shaped protruding portion 44 close to the barrel body 36).

0043In the female barrel 30 according to the present embodiment, a distal end protruding portion 46 that protrudes in the distal end direction from a distal end portion of the cylindrical portion 38, is provided integrally. The distal end protruding portion 46 extends in a ring shape in the circumferential direction concentrically with the cylindrical portion 38. In the present embodiment, an outer diameter of the distal end protruding portion 46 is smaller than the outer diameter Dc of the cylindrical portion 38. Note that the outer diameter of the distal end protruding portion 46 may be the same as the outer diameter Dc of the cylindrical portion 38, or may be larger than the outer diameter Dc of the cylindrical portion 38.

0044In <figref idref="f0001">Fig. 1</figref>, the gasket 32 is inserted into the barrel body 36 via the proximal end opening 36a that is open at the proximal end of the barrel body 36. The proximal end side of the barrel body 36 is sealed by the gasket 32 in a liquid-tight manner. The gasket 32 is made of an elastic material such as a rubber material. The gasket 32 has an outer circumferential portion being in liquid-tight contact with an inner circumferential surface of the barrel body 36 and is arranged to be slidable inside the barrel body 36.

0045The gasket 32 is connected to a distal end portion of the pusher 34. When a user presses the pusher 34 in the axial direction (distal end direction or proximal end direction), the gasket 32 slides in the axial direction inside the barrel body 36. Note that the pusher 34 may be connected to the gasket 32 at the time of using the female syringe 14.

0046In an initial state of the female syringe 14, a cap (not illustrated) is mounted on the cylindrical portion 38, and a distal end opening 38c (see <figref idref="f0003">Fig. 3</figref>) is sealed by this cap. The cap is detached from the cylindrical portion 38 at the time of using the female syringe 14 (at the time of using the syringe kit 10).

0047The medical liquid ML is a liquid in which the medicine M in the male syringe 12 can be dissolved, diluted, or mixed. Such a medical liquid ML may be a medicine solvent such as a physiological saline, a medicine diluent, a medicine mixture, or a medicinal solution containing a medicine (for example, vitamins and minerals). Note that the medical liquid ML is not necessarily poured in the female syringe 14 in advance as in the present embodiment, but may be sucked from a vial or the like into the empty female syringe 14 by the required amount as needed.

0048In the present embodiment, the male barrel 16 and the female barrel 30 are both made of a cyclic polyolefin having high rigidity and high toughness. Note that the male barrel 16 and the female barrel 30 may be made of polyesters such as polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly (4-methylpentene-1), an acrylic resin, an acrylonitrile-butadiene-styrene copolymer, and polyethylene terephthalate.

0049Next, a method for using the syringe kit 10 configured as described above will be described.

0050First, the caps (not illustrated) are detached (opened) from the nozzle 24 of the male barrel 16 and the cylindrical portion 38 of the female barrel 30, respectively, in the male syringe 12 and the female syringe 14 illustrated in <figref idref="f0001">Fig. 1</figref>.

0051Next, the male barrel 16 and the female barrel 30 are connected to each other as illustrated in <figref idref="f0006">Fig. 6</figref>. Specifically, the screw 28 (see <figref idref="f0002">Fig. 2</figref>) of the lock adapter 26 and the protrusion 42 (see <figref idref="f0003">Fig. 3</figref>) provided on the cylindrical portion 38 of the female barrel 30 are screwed. With this screwing, the nozzle 24 (male luer) of the male barrel 16 is inserted into the cylindrical portion 38 (female luer) of the female barrel 30. As a result, the tapered outer circumferential surface 24a (see <figref idref="f0002">Fig. 2</figref>) of the nozzle 24 is liquid-tightly fitted (taper-fitted) to the tapered inner circumferential surface 38a (see <figref idref="f0003">Fig. 3</figref>) of the cylindrical portion 38.

0052Next, the medical liquid ML and the medicine M are mixed by performing a pumping operation using the pusher 20 of the male syringe 12 and the pusher 34 of the female syringe 14. Specifically, the pusher 34 of the female syringe 14 is pressed in the distal end direction of the female syringe 14 to inject the medical liquid ML from the female barrel 30 into the male barrel 16, thereby mixing the medical liquid ML and the medicine M in the male barrel 16. Next, the pusher 20 of the male syringe 12 is pressed in the distal end direction of the male syringe 12 to inject a mixed liquid (mixture of the medical liquid ML and the medicine M) from the inside of the male barrel 16 into the inside of the female barrel 30. Then, the mixed liquid is repeatedly moved between the male barrel 16 and the female barrel 30 several times to promote dissolution, dilution, or mixing of the medicine M, whereby a desired medicinal solution is adjusted.

0053In this case, the cylindrical portion 38 of the female barrel 30 is provided with the two protrusions 42 that can be screwed to the screw 28 of the lock adapter 26 of the male barrel 16 according to the present embodiment. Further, the length Lp of the protrusion 42 along the direction perpendicular to the axis of the cylindrical portion 38 and perpendicular to the direction in which the protrusion 42 protrudes from the cylindrical portion 38 is 2.0 to 4.5 mm, and the width W of the protrusion 42 along the axial direction of the cylindrical portion 38 is 1.0 to 2.1 mm. In addition, the inclined surface 42a opposing the trailing flank of the screw 28 of the lock adapter 26 is provided at the end portion of the protrusion 42 close to the barrel body 36. For this reason, when the excessive torque is applied at the time of screwing the protrusion 42 and the screw 28 of the lock adapter 26, the protrusion 42 advances over the screw thread 28a of the lock adapter 26 (the protrusion 42 idles) as schematically illustrated in <figref idref="f0007">Fig. 7</figref>. Note that the protrusion 42 indicated by the virtual line in <figref idref="f0007">Fig. 7</figref> is the protrusion 42 before advancing over the screw thread 28a.

0054That is, when the screwing between the protrusion 42 and the screw 28 progresses to a certain extent, the fitting between the tapered outer circumferential surface 24a of the nozzle 24 and the tapered inner circumferential surface 38a of the cylindrical portion 38 is completed. Then, when the screw 28 is further screwed from this state, mainly the screw 28 (the lock adapter 26) is elastically deformed outward, so that the protrusion 42 advances over the screw thread 28a. Note that the expression that "the protrusion 42 advances over the screw thread 28a" does not mean that the protrusion 42 moves along the spiral shape of the screw 28, but means that the protrusion 42 moves from one side of the screw thread 28a to the other side across the top of the screw thread 28a.

0055Since the protrusion 42 advances over the screw thread 28a in this manner, no further relative displacement in the axial direction between the protrusion 42 and the screw 28 accompanying the screwing occurs, so that the nozzle 24 and the cylindrical portion 38 are not excessively fitted. As a result, excessive tightening can be prevented, damage and deformation of the cylindrical portion 38 of the female barrel 30 can be prevented, and deterioration in liquid tightness between the nozzle 24 and the cylindrical portion 38 can be prevented.

0056Meanwhile, a male reference connector is specified in ISO594-2 as a connector for testing a locking connector using screw connection. In the present embodiment, the protrusion 42 advances over the screw thread 28a of the lock adapter 26 at the time of screwing the screw 28 and the protrusion 42 by a torque smaller than a torque at which the female syringe 14 is damaged when a convex reference conical fitting for the stress crack test specified in ISO 594-2 is screwed with the female syringe 14. For this reason, it is possible to more reliably prevent the cylindrical portion 38 of the female syringe 14 from being damaged. Note that the convex reference conical fitting is made of a material having corrosion resistance (for example, stainless steel).

0057In the present embodiment, the ring-shaped protruding portion 44 (see <figref idref="f0004">Fig. 4</figref>) that protrudes outward from the distal end portion of the cylindrical portion 38 is provided, and the protrusion 42 is formed on the outer circumferential portion of the ring-shaped protruding portion 44. As a result, the protrusion 42 and the cylindrical portion 38 are reinforced. Therefore, when the protrusion 42 advances over the screw thread 28a of the lock adapter 26, the protrusion 42 and the cylindrical portion 38 are less likely to be deformed, and the liquid tightness between the nozzle 24 and the cylindrical portion 38 is kept favorable.

0058In the present embodiment, the distal end protruding portion 46 (see <figref idref="f0004">Fig. 4</figref>) that protrudes from the distal end portion of the cylindrical portion 38 toward the distal end is provided, and the distal end protruding portion 46 is located to be closer to the distal end than the protrusion 42. As a result, the protrusion 42 and the cylindrical portion 38 are reinforced. Therefore, when the protrusion 42 advances over the screw thread 28a of the lock adapter 26, the protrusion 42 and the cylindrical portion 38 are less likely to be deformed, and the liquid tightness between the nozzle 24 and the cylindrical portion 38 is kept favorable.

0059Since the female barrel 30 is made of the cyclic polyolefin having high rigidity and toughness in the present embodiment, when the protrusion 42 advances over the screw thread 28a of the lock adapter 26, the protrusion 42 and the cylindrical portion 38 are less likely to be deformed, and the liquid tightness between the nozzle 24 and the cylindrical portion 38 is kept favorable. In addition, since the male barrel 16 is also made of the cyclic polyolefin having high rigidity and toughness in the present embodiment, when the protrusion 42 advances over the screw thread 28a of the lock adapter 26, the nozzle 24 is less likely to be deformed, and the liquid tightness between the nozzle 24 and the cylindrical portion 38 is kept more favorable.

0060In the present embodiment, both the outer diameter D1 of the barrel body 22 of the male barrel 16 and the outer diameter D2 of the barrel body 36 of the female barrel 30 are 6.7 mm or more. In addition, both the axial length L1 of the barrel body 22 of the male barrel 16 and the axial length L2 of the barrel body 36 of the female barrel 30 are 35 mm or more. In general, in the case of a barrel for a syringe, provided with a barrel body having the above external dimensions, screwing is performed by gripping the barrel body, and thus, the screwing can be reliably performed, but it is easy to apply a strong torque so that it is easy to cause breakage or deformation. According to the present invention, however, the protrusion 42 advances over the screw thread 28a even if the barrel bodies 22 and 36 have the above-described external dimensions, and thus, it is possible to prevent the damage and deformation of the cylindrical portion 38 as described above, and the deterioration in liquid tightness between the nozzle 24 and the cylindrical portion 38 can be effectively prevented. Therefore, the present invention is particularly useful when the barrel bodies 22 and 36 have the above-described external dimensions.

0061In the present embodiment, the two protrusions 42 advance over the screw thread 28a of the lock adapter 26 by the predetermined torque at the time of screwing the screw 28 and the two protrusions 42, and the protrusions 42 (and the screw 28) generate the click feeling along with the advancement. For this reason, the user who has performed the screwing operation can easily know that the screwing between the protrusions 42 and the screw 28 has been completed based on the generated click feeling, and it is possible to quickly shift to the next step (the above-described mixing operation). Note that the protrusions 42 (and the screw 28) may generate a click sound together with the click feeling.

0062In the above-described syringe kit 10, a female syringe barrel 30a (hereinafter, abbreviated as the "female barrel 30a") according to a first modification illustrated in <figref idref="f0008">Figs. 8</figref> and <figref idref="f0009">9</figref> may be adopted, instead of the female barrel 30. The female barrel 30a is different from the female barrel 30 illustrated in <figref idref="f0001">Fig. 1</figref> and the like in terms that a cylindrical portion 39 is provided instead of the cylindrical portion 38. As illustrated in <figref idref="f0008">Fig. 8</figref>, the cylindrical portion 39 has two protrusions 43, which can be screwed with the screw 28 (see <figref idref="f0010">Fig. 10</figref>) provided on the lock adapter 26 of the male syringe 12, on opposite sides on an outer circumferential portion of the cylindrical portion 39.

0063In <figref idref="f0009">Fig. 9</figref>, a length Lpa of each of the protrusions 43 (the top of each of the protrusions 43) along the radial direction of the cylindrical portion 39 is set to 2.7 to 3.5 mm. A width Wa of each of the protrusions 43 (the top of each of the protrusions 43) along the axial direction of the cylindrical portion 39 is set to 1.5 to 2.1 mm. Note that the length Lpa of each of the protrusions 43 may be set to 2.0 to 4.5 mm similarly to the length Lp of each of the protrusions 42, and the width Wa of each of the protrusions 43 may be set to 1.0 to 2.1 mm similarly to the width W of each of the protrusions 42.

0064As illustrated in <figref idref="f0008">Fig. 8</figref>, each of the two protrusions 43 of the female barrel 30a is provided with an inclined surface 43a opposing the trailing flank of the screw 28 of the lock adapter 26 when the two protrusions 43 are screwed with the screw 28 of the lock adapter 26. The inclined surface 43a is configured in the same manner as the inclined surface 42a (see <figref idref="f0005">Fig. 5</figref>) provided on each of the protrusions 42 of the female barrel 30 described above. Each of the protrusions 43 has a chamfered corner 43b chamfered on a side surface opposing the inclined surface 42a. The chamfered corner 43b is an arcuate curved surface.

0065The cylindrical portion 39 includes an abutment portion 45 having an outer diameter Dd of 6.4 to 6.8 mm at a position closer to a proximal end than the two protrusions 43 on the outer circumferential portion of the cylindrical portion 39. As illustrated in <figref idref="f0010">Fig. 10</figref>, when the two protrusions 43 of the cylindrical portion 39 are screwed with the screw 28 of the lock adapter 26 of the male syringe 12, the abutment portion 45 abuts on an inner circumferential surface 27b of the screw 28 of the lock adapter 26 so as to suppress an inclination of an axis of the cylindrical portion 39 with respect to an axis of the lock adapter 26.

0066As illustrated in <figref idref="f0009">Fig. 9</figref>, the outer diameter Dd of the abutment portion 45 is constant along the axial direction of the cylindrical portion 39. The abutment portion 45 in the illustrated example is an annular surface (cylindrical surface) that extends over the entire circumference about the axis of the cylindrical portion 39. An external shape of the abutment portion 45 in a cross section perpendicular to the axis of the cylindrical portion 39 is not limited to a circle, but may be a non-circular shape such as a polygon. The abutment portion 45 may be present partially on the outer circumferential portion in the circumferential direction instead of the entire outer circumferential portion of the cylindrical portion 39.

0067The abutment portion 45 is provided continuously from proximal ends 43c of the two protrusions 43 to a position separated by at least 4 mm from a distal end 39a of the cylindrical portion 39 to the barrel body 36. A length Lt of the abutment portion 45 along the axial direction of the cylindrical portion 39 is preferably larger than the width Wa of the protrusion 43.

0068Even in the case of adopting this female barrel 30a, the protrusion 43 advances over the screw thread 28a of the lock adapter 26 when an excessive torque is applied at the time of screwing the protrusion 43 and the screw 28 of the lock adapter 26 as illustrated in <figref idref="f0010">Fig. 10</figref>. For this reason, excessive tightening can be prevented, damage and deformation of the cylindrical portion 39 of the female barrel 30a can be prevented, and deterioration in liquid tightness between the nozzle 24 and the cylindrical portion 39 can be prevented.

0069In addition, the female barrel 30a includes the abutment portion 45 having the outer diameter Dd of 6.4 to 6.8 mm at the position closer to the proximal end than the two protrusions 43 on the outer circumferential portion of the cylindrical portion 39. Therefore, the abutment portion 45 abuts on the inner circumferential surface 27b of the screw 28 of the lock adapter 26 when the two protrusions 43 of the cylindrical portion 39 are screwed with the screws 28 of the lock adapter 26 of the male syringe 12 as illustrated in <figref idref="f0010">Fig. 10</figref>, so that the inclination of the axis of the cylindrical portion 39 with respect to the axis of the lock adapter 26 is suppressed. For this reason, the cylindrical portion 39 can be prevented from breaking by being screwed with the axis being inclined.

0070That is, if the cylindrical portion 39 is screwed with the axis of the lock adapter 26 being inclined with respect to the axis of the lock adapter 26, there is a possibility that the cylindrical portion 39 breaks because stress applied to the cylindrical portion 39 becomes uneven in the circumferential direction. However, according to the female barrel 30a, the abutment portion 45 suppresses the inclination of the axis of the cylindrical portion 39 with respect to the axis of the lock adapter 26 as described above, and thus, it is possible to prevent the breakage of the cylindrical portion 39 due to the uneven stress in the circumferential direction.

0071In <figref idref="f0009">Fig. 9</figref>, the length Lpa of the protrusion 43 is 2.7 to 3.5 mm, the width Wa of the protrusion 43 is 1.5 to 2.1 mm, and the protrusion 43 has the chamfered corner 43b chamfered on the side surface opposing the inclined surface 43a. With the above chamfered corner 43b, a corner of the protrusion 43 does not interfere with the screw 28 when the protrusion 43 is formed to be large.

0072In the above-described syringe kit 10, a female syringe barrel 30A (hereinafter, abbreviated as the "female barrel 30A") according to a second modification illustrated in <figref idref="f0011">Fig. 11</figref> may be adopted instead of the female barrel 30. This female barrel 30A is obtained by adding a proximal-end-side protruding portion 50 to the female barrel 30 illustrated in <figref idref="f0001">Fig. 1</figref> and the like. The proximal-end-side protruding portion 50 protrudes from the outer circumferential portion of the cylindrical portion 38 and is provided at a position closer to the proximal end than the protrusion 42 with an interval in the axial direction of the cylindrical portion 38.

0073Specifically, the proximal-end-side protruding portion 50 includes a proximal-end-side ring-shaped protruding portion 52 that protrudes outward from the outer circumferential portion of the cylindrical portion 38 and two proximal-end-side protrusions 54 that protrude to outer sides, opposite to each other, with reference to the axis of the cylindrical portion 38. The proximal-end-side ring-shaped protruding portion 52 has the same configuration as the ring-shaped protruding portion 44. The two proximal-end-side protrusions 54 are provided on an outer circumferential portion of the proximal-end-side ring-shaped protruding portion 52, and have the same configuration as the two protrusions 42. In the cylindrical portion 38, the two proximal-end-side protrusions 54 are provided at the same circumferential positions as the two protrusions 42.

0074In this manner, the proximal-end-side protruding portion 50 protruding from the outer circumferential portion of the cylindrical portion 38 is provided at a position closer to the proximal end than the two protrusions 42 in the female barrel 30A. Therefore, the proximal-end-side protruding portion 50 abuts on an inner circumferential surface 27 of the lock adapter 26 when the two protrusions 42 of the cylindrical portion 38 are screwed with the screw 28 of the lock adapter 26 of the male syringe 12 as illustrated in <figref idref="f0012">Figs.12A and 12B</figref>, so that the inclination of the axis of the cylindrical portion 38 with respect to the axis of the lock adapter 26 is suppressed. For this reason, the cylindrical portion 38 can be prevented from breaking by being screwed with the axis being inclined.

0075That is, if the cylindrical portion 38 is screwed with the axis of the lock adapter 26 being inclined with respect to the axis of the lock adapter 26, there is a possibility that the cylindrical portion 38 breaks because stress applied to the cylindrical portion 38 becomes uneven in the circumferential direction. However, according to the female barrel 30A, the proximal-end-side protruding portion 50 suppresses the inclination of the axis of the cylindrical portion 38 with respect to the axis of the lock adapter 26 as described above, and thus, it is possible to prevent the breakage of the cylindrical portion 38 due to the uneven stress in the circumferential direction.

0076In this case, the inclination of the axis is prevented as the proximal-end-side protrusion 54 abuts on at least one of an inner circumferential surface 27a between the screw threads 28a of the lock adapter 26 and the inner circumferential surface 27b of the screw thread 28a of the lock adapter 26 during the screwing. That is, during the screwing, the proximal-end-side protrusion 54 opposes the inner circumferential surface 27a between the screw threads 28a of the lock adapter 26 (<figref idref="f0012">Fig. 12A</figref>), and the proximal-end-side ring-shaped protruding portion 52 opposes the inner circumferential surface 27b of the screw thread 28a of the lock adapter 26 (<figref idref="f0012">Fig. 12B</figref>). Accordingly, in the female barrel 30A in the illustrated example, the inclination of the axis is prevented as the proximal-end-side protrusion 54 and the proximal-end-side ring-shaped protruding portion 52 function as abutment portions that abut on the inner circumferential surface 27a between the screw threads 28a of the lock adapter 26 and the inner circumferential surface 27b of the screw thread 28a of the lock adapter 26, respectively, during the screwing. In this manner, the inner circumferential surface 27 of the lock adapter 26 includes the inner circumferential surface 27a between the screw threads 28a and the inner circumferential surface 27b of the screw thread 28a.

0077Note that, during the screwing, the proximal-end-side protrusion 54 may abut on the inner circumferential surface 27a between the screw threads 28a of the lock adapter 26, and the proximal-end-side ring-shaped protruding portion 52 does not necessarily abut on the inner circumferential surface 27b of the screw thread 28a of the lock adapter 26. Alternatively, during the screwing, the proximal-end-side ring-shaped protruding portion 52 may abut on the inner circumferential surface 27b of the screw thread 28a of the lock adapter 26, and the proximal-end-side protrusion 54 does not necessarily abut on the inner circumferential surface 27a between the screw threads 28a of the lock adapter 26. In addition, the proximal-end-side protrusion 54 may be omitted, and the proximal-end-side ring-shaped protruding portion 52 may function as the abutment portion that abuts on the inner circumferential surface 27b of the screw thread 28a of the lock adapter 26 during the screwing. In this case, the outer diameter of the proximal-end-side ring-shaped protruding portion 52 is preferably 6.4 to 6.8 mm.

0078Even in the case of adopting this female barrel 30A, the protrusion 42 advances over the screw thread 28a of the lock adapter 26 as schematically illustrated in <figref idref="f0013">Fig. 13</figref> when an excessive torque is applied at the time of screwing the protrusion 42 and the screw 28 of the lock adapter 26. At this time, the proximal-end-side protrusion 54 also advances over the screw thread 28a similarly to the protrusion 42. For this reason, excessive tightening can be prevented, damage and deformation of the cylindrical portion 38 of the female barrel 30A can be prevented, and deterioration in liquid tightness between the nozzle 24 and the cylindrical portion 38 can be prevented.

0079In the above-described syringe kit 10, a female syringe barrel 30B (hereinafter, abbreviated as the "female barrel 30B") according to a third modification illustrated in <figref idref="f0014">Fig. 14</figref> may be adopted instead of the female barrel 30. The female barrel 30B has a female barrel main body 60 and an outer cylinder 62 that surrounds an outer circumferential portion of the cylindrical portion 38 of the female barrel main body 60 and is not rotatable with respect to the cylindrical portion 38. The female barrel main body 60 has the same configuration as the above-described female barrel 30, and thus, its components are denoted by the same reference signs as those of the female barrel 30.

0080The outer cylinder 62 illustrated in <figref idref="f0014">Fig. 14</figref> is configured to be detachable from the female barrel main body 60. Specifically, the outer cylinder 62 has: a body portion 64 that covers the barrel body 36 of the female barrel main body 60; a distal end cylindrical portion 66 extending in a distal end direction from a distal end of the body portion 64; and a pair of engagement portions 68 protruding to outer sides, opposite to each other, from a proximal end of the body portion 64.

0081The outer cylinder 62 is made of a transparent material (for example, the same material as the female barrel main body 60) such that the female barrel main body 60 (and the inside thereof) arranged inside can be visually recognized. The distal end cylindrical portion 66 is a hollow cylindrical body surrounding the cylindrical portion 38 of the female barrel main body 60, and is arranged concentrically with the cylindrical portion 38. An annular space is formed between the distal end cylindrical portion 66 and the cylindrical portion 38.

0082The distal end cylindrical portion 66 is formed so as to cover the protrusion 42 provided on the cylindrical portion 38. Specifically, in a state where the outer cylinder 62 is mounted on the female barrel main body 60 as illustrated in <figref idref="f0015">Fig. 15</figref>, a distal end surface 66a of the distal end cylindrical portion 66 is located to be closer to the distal end than a distal end surface 42b of the protrusion 42 provided on the cylindrical portion 38. Note that the distal end surface 66a of the distal end cylindrical portion 66 may be located at an axial position between the distal end surface 42b and a proximal end surface 42c of the protrusion 42. An inner diameter of the distal end cylindrical portion 66 is slightly larger than an outer diameter of the lock adapter 26 of the male barrel 16.

0083In <figref idref="f0014">Fig. 14</figref>, the pair of engagement portions 68 is engaged with edges of the flange 40 of the female barrel main body 60 on both sides in the short-axis direction. As a result, the outer cylinder 62 is not rotatable with respect to the female barrel main body 60. A hook that engages with a proximal end surface of the flange 40 may be provided on the engagement portion 68 such that the outer cylinder 62 is not detached from the female barrel main body 60.

0084In this manner, the outer cylinder 62 that surrounds the outer circumferential portion of the cylindrical portion 38 and is not rotatable with respect to the cylindrical portion 38 is provided in the female barrel 30B. Therefore, as illustrated in <figref idref="f0015">Fig. 15</figref>, when the two protrusions 42 of the cylindrical portion 38 are screwed with the screw 28 of the lock adapter 26 of the male syringe 12, the lock adapter 26 is inserted between the cylindrical portion 38 and the outer cylinder 62. At this time, an inner circumferential surface of the outer cylinder 62 abuts on the outer circumferential surface of the lock adapter 26, thereby suppressing the inclination of the axis of the cylindrical portion 38 with respect to the axis of the lock adapter 26. For this reason, the cylindrical portion 38 can be prevented from breaking by being screwed with the axis being inclined.

0085Note that the outer cylinder 62 is not limited to the shape that surrounds most of the female barrel main body 60 as described above, and may be formed integrally with the female barrel main body 60 only around the cylindrical portion 38.

0086Although the case where the male syringe 12 is filled with the medicine M, and the female syringe 14 is filled with the medical liquid ML has been exemplified in the above-described embodiment, the fillings may be reversed between the male syringe 12 and the female syringe 14. That is, the male syringe 12 may be filled with the medical liquid ML, and the female syringe 14 may be filled with the medicine M.

0087The present invention is not limited to the above-described embodiment, and various modifications can be made within a scope not departing from a gist of the present invention.