Nova Patents
EP1950221A3

Genomic sequences of exported mycobacteria polypeptides, vectors containing them and applications to the diagnosis and prevention of tuberculosis

Abstract

The subject of the invention is recombinant vectors that replicate in mycobacteria, a set of sequences coding for exported polypeptides detected by fusions with alkaline phosphatase, in particular a polypeptide, called DP428, of about 12 kD corresponding to an exported protein found. in mycobacteria belonging to the complex of Mycobacterium tuberculosis. The invention also relates to methods and kits for the in vitro detection of the presence of a mycobacterium and in particular a mycobacterium belonging to the Mycobacterium tuberculosis in a biological sample using said polypeptides, their fragments or polynucleotides encoding them. The invention relates to immunogenic compositions or vaccines for the prevention and / or treatment of infections caused by mycobacteria and in particular a mycobacterium belonging to said complex, in particular tuberculosis.

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Term ended

Projected expiry passed 14 August 2018, 8.1 years ago.

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Citations
DocumentRelationOfficeCategoryCited duringRelevant claims
WO9506726A2CitesWorld Intellectual Property Organization (WIPO)XSearch report1-5,7-9,11-23
DATABASE EMBL [online] 16 December 1995 (1995-12-16), "yx17b03.s1 Soares melanocyte 2NbHM Homo sapiens cDNA clone IMAGE:261965 3' similar to gb:J04111_cds1 TRANSCRIPTION FACTOR AP-1 (HUMAN);, mRNA sequence.", XP002530467, retrieved from EBI accession no. EMBL:H98664 Database accession no. H98664Non-patent––Search report–
DATABASE EMBL [online] 20 December 1994 (1994-12-20), "893R Heart Homo sapiens cDNA clone 893 similar to 7S L gene, mRNA sequence.", XP002530468, retrieved from EBI accession no. EMBL:T19702 Database accession no. T19702Non-patent––Search report–
ENG MONG LIM ET AL.: "Identification of Mycobacterium tuberculosis DNA sequences encoding exported proteins by using phoA gene fusions", JOURNAL OF BACTERIOLOGY, vol. 177, no. 1, 1 January 1995 (1995-01-01), pages 59 - 65, XP000560419Non-patent––Search report–
DATABASE UniProt [online] 1 June 1998 (1998-06-01), "SubName: Full=POSSIBLE EXPORTED PROTEIN; SubName: Full=Putative uncharacterized protein;", XP002530469, retrieved from EBI accession no. UNIPROT:O53654 Database accession no. O53654Non-patent––Search report–