Plenylacetate and derivatives alone or in combination with other compounds against neoplastic conditions and other disorders
Abstract
Compositions and methods of treating various disorders by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof alone or in combination or in conjunction with other therapeutic agents including retinoids, hydroxyurea, and flavonoids. Intravesicle methods of treatment of cancers phenylacetate. Pharmacologically-acceptable salts alone or in combinations and methods of preventing AIDS and malignant conditions, and inducing cell differentiation are also aspects of this invention. A product as a combined preparation of phenylacetate and a retinoid, hydroxyurea, or flavonid (or other mevalonate pathway inhibitor) for simultaneous, separate, or sequential use in treating a neoplastic condition in a subject. Methods of modulating lipid metabolism and/or reducing serum triglycerides in a subject using phenylacetate.
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Projected expiry passed 12 October 2014, 12 years ago.
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Every citation, both ways
| Document | Relation | Office | Category | Cited during | Relevant claims |
|---|---|---|---|---|---|
| EP0069232A2 | Cites | European Patent Office (EPO) | Y | Search report | 1-6,60-64,69 |
| W. NEISH: "Phenylacetic acid as a potential therapeutic Agent for the treatment of human cancer", EXPERIENTIA, vol. 27, 1971 - 1971, pages 860 - 861, XP002317232 | Non-patent | – | – | Search report | – |
| S.R. BURZYNSKI: "Preclinical studies on Antineoplaston AS2-1 and Antineoplaston AS2-5", DRUGS EXP. CLIN. RES., vol. 12, 1986 - 1986, pages 11 - 16, XP002317233 | Non-patent | – | – | Search report | – |
| Y. SHECHTER ET AL.: "Hydroxyphenyl acetate derivatives inhibit protein tyrosine kinase activity and proliferation in Nb2 rat lymphoma cells and insulin-induced lipogenesis in rat adipocytes", MOL. CELL. ENDOCRINOL., vol. 80, no. 1-3, 1991 - 1991, pages 183 - 192, XP002317234 | Non-patent | – | – | Search report | – |
| D. SAMID ET AL.: "Phenylacetate: A novel nontoxic inducer of tumor cell differentiation", CANCER RES., vol. 52, no. 7, 1992 - 1992, pages 1988 - 1992, XP002317235 | Non-patent | – | – | Search report | – |
| D. SAMID ET AL.: "Interferon in combination with antitumourigenic phenyl derivatives: potentiation of IFN alpha activity in-vitro", BR. J. HAEMATOL., vol. 79, 10 October 1991 (1991-10-10), pages 81 - 83, XP002317236 | Non-patent | – | – | Search report | – |
| ABEMAYOR E ET AL: "Effects of retinoic acid on the in vivo growth of human neuroblastoma cells.", CANCER LETT (NETHERLANDS), NOV 19 1990, VOL. 55, NO. 1, PAGE(S) 1-5,, 1990, XP002317237 | Non-patent | – | – | Search report | – |
| CINATL J ET AL: "In vitro differentiation of human neuroblastoma cells induced by sodium phenylacetate.", CANCER LETT (NETHERLANDS), JUN 15 1993, VOL. 70, NO. 1-2, PAGE(S) 15-24,, 1993 - 1993, XP002317238 | Non-patent | – | – | Search report | – |
| GORSKI GK ET AL: "Synergistic inhibition of human rhabdomyosarcoma cells by sodium phenylacetate and Tretinoin [letter]", IN VITRO CELL DEV BIOL (UNITED STATES), MAR 1993, VOL. 29A (3 PT 1, PAGE(S) 189-91,, 1993, XP002317239 | Non-patent | – | – | Search report | – |
| WADA R ET AL: "Effects of phenylacetate and its interaction with retinoic acid on human neuroblastoma differentiation", PROCEEDINGS OF THE AMERICAN ASSOC. FOR CANCER RESEARCH ANNUAL MEETING, vol. 35, March 1994 (1994-03-01), pages 419, XP002317240 | Non-patent | – | – | Search report | – |
| LIU L ET AL: "Differentiation of cultured human melanoma cells induced by the aromatic fatty acids phenylacetate and phenylbutyrate.", J INVEST DERMATOL (UNITED STATES), SEP 1994, VOL. 103, NO. 3, PAGE(S) 335-40,, 1994, XP002317241 | Non-patent | – | – | Search report | – |
| WOOD C G ET AL: "Phenylacetate and retinoic acid act synergistically to promote cellular differentiation in the prostate cancer cell lines LNCaP", J. UROL., vol. 151, no. 5, May 1994 (1994-05-01), pages 491A, XP002317242 | Non-patent | – | – | Search report | – |
86 members in 16 offices
Priority claims5
| Document | Office | Kind | Date |
|---|---|---|---|
| 135661 | United States of America | – | |
| 13566193 | United States of America | A | |
| 207521 | United States of America | – | |
| 20752194 | United States of America | A | |
| 94930694 | European Patent Office (EPO) | A |
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| AT213409T | Austria | T | |
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| EP1108427A3 | European Patent Office (EPO) | A3 | |
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| EP1484059A2 | European Patent Office (EPO) | A2 | |
| EP0725635B1 | European Patent Office (EPO) | B1 | |
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| DE69434211D1 | Germany | D1 | |
| JP3628694B2 | Japan | B2 | |
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| EP1484058A3 | European Patent Office (EPO) | A3 | |
| EP1523982A3This record | European Patent Office (EPO) | A3 | |
| PT725635E | Portugal | E | |
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| EP1523982B1 | European Patent Office (EPO) | B1 | |
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| DK1523982T3 | Denmark | T3 | |
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| EP1484059B1 | European Patent Office (EPO) | B1 | |
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| SI1523982T1 | Slovenia | T1 | |
| DK1484059T3 | Denmark | T3 | |
| EP1484058B1 | European Patent Office (EPO) | B1 | |
| AT418975T | Austria | T | |
| ATE418975T1 | Austria | T1 | |
| DE69233754D1 | Germany | D1 | |
| ES2312884T3 | Spain | T3 | |
| DE69435086T2 | Germany | T2 |
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Numbers
- Publication
- 1523982
- Application
- 40309122
Titles3
- German
- Phenylacetate und Derivate, allein oder in Kombination mit anderen Verbindungen, zur Behandlung von neoplastischen und anderen Erkrankungen
- English
- Plenylacetate and derivatives alone or in combination with other compounds against neoplastic conditions and other disorders
- French
- Phenylacetate et ses dérivés seuls ou associés à d'autres composés pour traiter des neoplasmes et d'autres troubles
Classification
- CPC, 37
- A61K31/35
- A61K31/19
- A61K31/192
- A61K31/20
- A61K31/22
- A61K31/365
- A61K31/70
- A61K31/7072
- A61K31/7076
- A61K38/212
- A61K45/06
- A61P1/04
- A61P13/02
- A61P13/08
- A61P13/10
- A61P13/12
- A61P15/00
- A61P17/00
- A61P17/02
- A61P19/02
- A61P25/00
- A61P27/02
- A61P29/00
- A61P3/00
- A61P31/04
- A61P31/12
- A61P31/18
- A61P35/00
- A61P3/06
- A61P3/08
- A61P37/02
- A61P37/04
- A61P37/06
- A61P43/00
- A61P7/00
- A61P9/00
- A61P3/10
- IPC, 45
- A61K31 353
- A61K
- A61K31 035
- A61K31 07
- A61K31 12
- A61K31 17
- A61K31 19
- A61K31 192
- A61K31 20
- A61K31 22
- A61K31 35
- A61K31 365
- A61K31 70
- A61K31 7072
- A61K31 7076
- A61K38 21
- A61K38 22
- A61K45 00
- A61K45 06
- A61P1 04
- A61P3 00
- A61P3 06
- A61P3 08
- A61P3 10
- A61P7 00
- A61P9 00
- A61P13 02
- A61P13 08
- A61P13 10
- A61P13 12
- A61P15 00
- A61P17 00
- A61P17 02
- A61P19 02
- A61P25 00
- A61P27 02
- A61P29 00
- A61P31 04
- A61P31 12
- A61P31 18
- A61P35 00
- A61P37 02
- A61P37 04
- A61P37 06
- A61P43 00
Designated states19
- Contracting states, 17
- Austria
- Belgium
- Switzerland
- Germany
- Denmark
- Spain
- France
- United Kingdom
- Greece
- Ireland
- Italy
- Liechtenstein
- Luxembourg
- Monaco
- Netherlands (Kingdom of the)
- Portugal
- Sweden
- Extension states, 2
- Lithuania
- Slovenia