EP0952218A3
Single chain, multiple antigen-binding molecule, its preparation and use
Abstract
The invention relates to a single-chain, multi-antigen binding molecule, with different variable domains of a heavy or a light chain of an immunoglobulin, which are connected in the form of a VH-VL-Konstuktes, which in turn are linked together via a peptide, and their preparation and Use as a drug or diagnostic.
Term
Term ended
Projected expiry passed 8 April 2019, 7.5 years ago.
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Every citation, both waysCites: the store holds 0 of 1
| Reference | Relation | Cited during |
|---|---|---|
| Z. ZHU ET AL.: "Remodeling domain interfaces to enhance heterodimer formation.", PROTEIN SCIENCE, vol. 6, no. 4, April 1997 (1997-04-01), New York, NY, VSA, pages 781 - 788, XP000929847 | Non-patent | Search report |
| K. FITZGERALD ET AL.: "Improved tumour targeting by disulphide stabilized diabodies expressed in Pichia pastoris.", PROTEIN ENGINEERING, vol. 10, no. 10, October 1997 (1997-10-01), Oxford, GB, pages 1221 - 1225, XP002144896 | Non-patent | Search report |
| R. KONTERMANN ET AL.: "Enzyme immunoassays using bispecific diabodies.", IMMUNOTECHNOLOGY, vol. 3, no. 2, June 1997 (1997-06-01), Amsterdam, die Niederlande, pages 137 - 144, XP002144897 | Non-patent | Search report |
| P. HOLLIGER ET AL.: "Specific killing of lymphoma cells by cytotoxic T-cells mediated by a bispecific antibody.", PROTEIN ENGINEERING, vol. 9, no. 3, March 1996 (1996-03-01), Oxford, GB, pages 299 - 305, XP002144898 | Non-patent | Search report |
| M. GRUBER ET AL.: "Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed in Escherichia coli.", THE JOURNAL OF IMMUNOLOGY, vol. 152, no. 11, 1 June 1994 (1994-06-01), Baltimore, MD, VSA, pages 5368 - 5374, XP000872832 | Non-patent | Search report |
| S. BRÜSSELBACH ET AL.: "Enzyme recruitment and tumor cell killing in vitro by a secreted bispecific single-chain diabody.", TUMOR TARGETING, vol. 4, no. 2, July 1999 (1999-07-01), London, GB, pages 115 - 123, XP000929842 | Non-patent | Search report |
| R. KONTERMANN ET AL.: "Bispecific single-chain diabodies.", EUROPEAN JOURNAL OF CANCER, vol. 35, no. suppl. 5, October 1999 (1999-10-01), Oxford, GB, pages S58, XP000929846 | Non-patent | Search report |
34 members in 16 offices
Priority claims10
| Document | Office | Kind | Date |
|---|---|---|---|
| 19816141 | Germany | A | |
| 19816141 | Germany | A | |
| 19816141 | Germany | – | |
| 19827239 | Germany | A | |
| 19827239 | Germany | A | |
| 19827239 | Germany | – | |
| 19816141 | – | – | – |
| 19827239 | – | – | – |
| DE1998116141 | – | – | – |
| DE1998127239 | – | – | – |
Members34
| Document | Office | Kind | |
|---|---|---|---|
| HU9900956D0 | Hungary | D0 | |
| CA2268258A1 | Canada | A1 | |
| CZ121599A3 | Czechia | A3 | |
| DE19816141A1 | Germany | A1 | |
| EP0952218A2 | European Patent Office (EPO) | A2 | |
| AU2365699A | Australia | A | |
| CN1234406A | China | A | |
| KR19990083043A | Republic of Korea | A | |
| DE19827239A1 | Germany | A1 | |
| BR9902039A | Brazil | A | |
| JP2000201678A | Japan | A | |
| EP0952218A3This record | European Patent Office (EPO) | A3 | |
| HUP9900956A2 | Hungary | A2 | |
| AU767580B2 | Australia | B2 | |
| AU2004200632A1 | Australia | A1 | |
| US6759518B1 | United States of America | B1 | |
| AU767580C | Australia | C | |
| US2005004352A1 | United States of America | A1 | |
| EP0952218B1 | European Patent Office (EPO) | B1 | |
| AT414150T | Austria | T | |
| ATE414150T1 | Austria | T1 | |
| DE59914902D1 | Germany | D1 | |
| PT952218E | Portugal | E | |
| DK0952218T3 | Denmark | T3 | |
| EP2036926A2 | European Patent Office (EPO) | A2 | |
| ES2317680T3 | Spain | T3 | |
| HK1130498A | Hong Kong, China | A | |
| US2009326206A1 | United States of America | A1 | |
| US7838637B2 | United States of America | B2 | |
| EP2036926A3 | European Patent Office (EPO) | A3 | |
| CA2268258C | Canada | C | |
| EP2036926B1 | European Patent Office (EPO) | B1 | |
| JP5306564B2 | Japan | B2 | |
| DK2036926T3 | Denmark | T3 |
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| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
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| Transmission of propertyTP | TP | FR | |
| Ep patent validated in greeceEP | EP | GR | |
| Ep patent with danish claimsT3 | T3 | DK | |
| New agentNV | NV | CH | |
| Translation of granted ep patentGrantedTRGR | TRGR | SE | |
| Translation is availableAVAILABILITY OF NATIONAL TRANSLATIONSC4A | SC4A | PT | |
| Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)732E | 732E | GB | |
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| European patents granted designating irelandGrantedLANGUAGE OF EP DOCUMENT: GERMANFG4D | FG4D | IE | |
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Numbers
- Publication
- 0952218
- Publication, DOCDB
- 0952218
- Publication, EPODOC
- EP0952218
- Application
- 99106176
- Application, DOCDB
- 99106176
- Application, EPODOC
- EP19990106176
Titles3
- German
- Einzelkettiges, mehrfach-antigenbindendes Moleküll, dessen Herstellung und Verwendung
- English
- Single chain, multiple antigen-binding molecule, its preparation and use
- French
- Molécule monocaténaire de liaison aux antigènes multiples, sa préparation et son utilisation
Classification
- CPC, 14
- C07K16/00
- C07K16/468
- A61K48/00
- A61K2039/505
- C07K16/3007
- C07K16/40
- C07K2317/626
- C07K2319/00
- C07K2317/34
- A61P25/00
- A61P31/00
- A61P35/00
- A61P37/00
- A61P7/00
- IPC, 21
- A61K31 00
- A61K35 74
- A61K35 76
- A61K38 00
- A61K39 00
- A61K48 00
- A61P7 00
- A61P25 00
- A61P31 00
- A61P35 00
- A61P37 00
- C07K16 00
- C07K16 30
- C07K16 40
- C07K16 46
- C12N15 00
- C12N1 19
- C12N1 21
- C12N5 10
- C12N15 12
- C12N15 13
Designated states2
- Contracting states, 1
- Sweden
- Extension states, 1
- Slovenia