Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis.
Abstract
Ultrasonic apparatus and method for coupling ultrasonic energy into intravascular walls to enhance phonophoresis and for dissolution of intravascular blockages. The apparatus includes a radiator for coupling ultrasonic waves and a piezoelectric crystal, connected with said radiator, for the intravascular generation of ultrasonic waves; said ultrasonic waves being propagated along a longitudinal axis of said piezoelectric crystal. A seed liquid is introduced proximate the radiator for promoting cavitation of intravascular fluid. In addition, enhancement of dissolution of intravascular blockages and inhibition of restenosis by chemical agents is significantly increased when combined with ultrasonic energy.
Term
Term ended
Projected expiry passed 13 September 2013, 13 years ago.
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Every citation, both ways
| Document | Relation | Office | Category | Cited during | Relevant claims |
|---|---|---|---|---|---|
| EP0316796A2 | Cites | European Patent Office (EPO) | Y | Search report | 1-10 |
| EP0332871A2 | Cites | European Patent Office (EPO) | A | Search report | 2,3 |
| US5040537A | Cites | United States of America | A | Search report | 4,5,9 |
| WO8605990A1 | Cites | World Intellectual Property Organization (WIPO) | A | Search report | 10 |
| WO8701276A1 | Cites | World Intellectual Property Organization (WIPO) | A | Search report | 1,6 |
| WO9210140A1 | Cites | World Intellectual Property Organization (WIPO) | YD | Search report | 1-10 |
15 members in 8 offices
Priority claims9
| Document | Office | Kind | Date |
|---|---|---|---|
| 94527592 | United States of America | A | |
| 94527592 | United States of America | A | |
| 5822293 | United States of America | A | |
| 5822293 | United States of America | A | |
| 9308591 | United States of America | W | |
| 9308591 | United States of America | W | |
| US19920945275 | – | – | – |
| US19930058222 | – | – | – |
| WO1993US08591 | – | – | – |
Members15
| Document | Office | Kind | |
|---|---|---|---|
| WO9406355A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AU4858093A | Australia | A | |
| US5318014A | United States of America | A | |
| US5362309A | United States of America | A | |
| EP0664686A1 | European Patent Office (EPO) | A1 | |
| EP0664686A4This record | European Patent Office (EPO) | A4 | |
| US5474531A | United States of America | A | |
| JPH08501238A | Japan | A | |
| EP0664686B1 | European Patent Office (EPO) | B1 | |
| AT182259T | Austria | T | |
| ATE182259T1 | Austria | T1 | |
| DE69325715D1 | Germany | D1 | |
| ES2135490T3 | Spain | T3 | |
| DE69325715T2 | Germany | T2 | |
| JP3561274B2 | Japan | B2 |
46 legal events, as 6 offices reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | Office | |
|---|---|---|---|
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Announcement of lapse in spainLapsedFD2A | FD2A | ES | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Notification of lapseLapsedST | ST | FR | |
| Gb: european patent ceased through non-payment of renewal feeCeasedGBPC | GBPC | EP | |
| Lapsed because of non-payment of the annual feeLapsedV1 | V1 | NL | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| European patent in force as of 2002-01-01IF02 | IF02 | GB | |
| No opposition filedOpposition26N | 26N | EP | |
| No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE | PLBE | EP | |
| Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA | STAA | EP | |
| Patent ceasedCeasedPL | PL | CH | |
| Definitive protectionFG2A | FG2A | ES | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Fr: translation filedET | ET | EP | |
| Correction of patent specification (title page) publishedK2C1 | K2C1 | EP | |
| Corresponds to:REF | REF | EP | |
| European patent takes effect as a national patent in ch/liEP | EP | CH | |
| Designated contracting statesAK | AK | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Corresponds to:REF | REF | EP | |
| (expected) grantORIGINAL CODE: 0009210GRAA | GRAA | EP | |
| Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOS IGRAGRAH | GRAH | EP | |
| Despatch of communication of intention to grantORIGINAL CODE: EPIDOS AGRAGRAG | GRAG | EP | |
| Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOS IGRAGRAH | GRAH | EP | |
| Despatch of communication of intention to grantORIGINAL CODE: EPIDOS AGRAGRAG | GRAG | EP | |
| First examination report despatched17Q | 17Q | EP | |
| Supplementary search report drawn up and despatchedA4 | A4 | EP | |
| Designated contracting statesAK | AK | EP | |
| Request for examination filed17P | 17P | EP | |
| Designated contracting statesAK | AK | EP | |
| Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI | PUAI | EP |
Numbers
- Publication, DOCDB
- 0664686
- Publication, EPODOC
- EP0664686
- Application
- 93921513
- Application, DOCDB
- 93921513
- Application, EPODOC
- EP19930921513
Titles3
- German
- VORRICHTUNG UND VERFAHREN ZUR VERBESSERTEN INTRAVASKULäREN PONOPHORESEMIT AUFLöSUNG VON INTRAVASKULäREN VERSCHLüSSEN UND VERMEIDUNG VONRESTENOSIS.
- English
- APPARATUS AND METHOD FOR ENHANCED INTRAVASCULAR PHONOPHORESIS INCLUDING DISSOLUTION OF INTRAVASCULAR BLOCKAGE AND CONCOMITANT INHIBITION OF RESTENOSIS.
- French
- APPAREIL ET PROCEDE AMELIORANT LA PHONOPHORESE INTRAVASCULAIRE, COMPRENANT LA DISSOLUTION D'OCCLUSIONS INTRAVASCULAIRES ET L'INHIBITION CONCOMITANTE DE RESTENOSES.
Classification
- CPC, 6
- A61B17/2202
- A61B2017/22002
- A61B2017/22008
- A61B2017/22021
- A61B2017/22082
- A61M37/0092
- IPC, 5
- A61B17 00
- A61B17 22
- A61B18 00
- A61M5 14
- A61M37 00
Designated states12
- Contracting states, 12
- Austria
- Belgium
- Switzerland
- Germany
- Denmark
- Spain
- France
- United Kingdom
- Italy
- Liechtenstein
- Netherlands (Kingdom of the)
- Sweden