EP0321201A3

Ribozymes

Abstract

Synthetic RNA molecules having highly specific endoribonuclease activity (hereinafter referred to as "ribozymes") are described. The ribozymes comprise a hybridizing region which is complementary in nucleotide sequence to at least part of a target RNA, and a catalytic region which is adapted to cleave the target RNA. Methods for inactivating RNA, and compositions containing ribozymes are also described.

EP0321201A3, drawing sheet 1 — Sheet 1 of 1

Term

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Projected expiry passed 14 December 2008, 17.8 years ago.

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Citations
Document	Relation	Office	Category	Cited during
WO8804300A1	Cites	World Intellectual Property Organization (WIPO)	XPD	Search report

54 members in 26 offices

This recordMember, by publication datePriority claim16 more offices are in the list below

Priority claims25

Priority claims
Document	Office	Kind	Date
591187	Australia	–	1987-12-15
PI591187	Australia	A	1987-12-15
PI591187	Australia	A	1987-12-15
995088	Australia	–	1988-08-19
PI995088	Australia	A	1988-08-19
PI995088	Australia	A	1988-08-19
35388	Australia	–	1988-09-09
PJ035388	Australia	A	1988-09-09
PJ035388	Australia	A	1988-09-09
130488	Australia	–	1988-11-04
PJ130488	Australia	A	1988-11-04
PJ130488	Australia	A	1988-11-04
133388	Australia	–	1988-11-07
PJ133388	Australia	A	1988-11-07
PJ133388	Australia	A	1988-11-07
130488	–	–	–
133388	–	–	–
35388	–	–	–
591187	–	–	–
995088	–	–	–
AU1987PI05911	–	–	–
AU1988PI09950	–	–	–
AU1988PJ00353	–	–	–
AU1988PJ01304	–	–	–
AU1988PJ01333	–	–	–

Members54

Family members, oldest first
Document	Office	Kind
EP0321201A2	European Patent Office (EPO)	A2	1989-06-21
WO8905852A1	World Intellectual Property Organization (WIPO)	A1	1989-06-29
CN1033838A	China	A	1989-07-12
AU2800789A	Australia	A	1989-07-19
ZA889352B	South Africa	B	1989-12-27
EP0321201A3This record	European Patent Office (EPO)	A3	1990-01-10
DK143390D0	Denmark	D0	1990-06-12
NO902661D0	Norway	D0	1990-06-14
DK143390A	Denmark	A	1990-08-14
NO20000369L	Norway	L	1990-08-14
NO902661L	Norway	L	1990-08-14
KR900700603A	Republic of Korea	A	1990-08-16
HUT54407A	Hungary	A	1991-02-28
JPH03502638A	Japan	A	1991-06-20
MC2115A1	Monaco	A1	1991-07-05
NZ227332A	New Zealand	A	1991-08-27
AU632993B2	Australia	B2	1993-01-21
IN171821B	India	B	1993-01-23
BG51160A3	Bulgaria	A3	1993-02-15
AR243935A1	Argentina	A1	1993-09-30
US5254678A	United States of America	A	1993-10-19
EP0321201B1	European Patent Office (EPO)	B1	1994-12-21
AT115999T	Austria	T	1995-01-15
DE3852539D1	Germany	D1	1995-02-02
EP0640688A1	European Patent Office (EPO)	A1	1995-03-01
ES2065919T3	Spain	T3	1995-03-01
DE3852539T2	Germany	T2	1995-05-04
GR3015374T3	Greece	T3	1995-06-30
IL88683A	Israel	A	1995-11-27
HU211891A9	Hungary	A9	1995-12-28
US5494814A	United States of America	A	1996-02-27
US5543508A	United States of America	A	1996-08-06
US5574143A	United States of America	A	1996-11-12
US5589580A	United States of America	A	1996-12-31
KR970010758B1	Republic of Korea	B1	1997-06-30
US5707835A	United States of America	A	1998-01-13
US5747335A	United States of America	A	1998-05-05
US5766942A	United States of America	A	1998-06-16
SG52270A1	Singapore	A1	1998-09-28
US5840874A	United States of America	A	1998-11-24
RO114469B1	Romania	B1	1999-04-30
CA1340831C	Canada	C	1999-11-30
RU2144080C1	Russian Federation	C1	2000-01-10
NO20000369D0	Norway	D0	2000-01-25
FI104562B	Finland	B	2000-02-29
JP3046318B2	Japan	B2	2000-05-29
NO308610B1	Norway	B1	2000-10-02
US6127114A	United States of America	A	2000-10-03
NO312105B1	Norway	B1	2002-03-18
CN1102174C	China	C	2003-02-26
EP0321201B2	European Patent Office (EPO)	B2	2004-11-24
ES2065919T5	Spain	T5	2005-06-16
DE3852539T3	Germany	T3	2005-08-04
DK175956B1	Denmark	B1	2005-08-22

74 legal events, as 7 offices reported them to INPADOC

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	Event	Code	Office
2009-08-31	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-06-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-04-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-03-16	Announcement of lapse in spainLapsedFD2A	FD2A	ES
2009-02-17	Se: european patent has lapsedLapsedEUG	EUG	EP
2009-01-30	Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25	PG25	EP
2009-01-07	Patent expired after termination of 20 yearsExpiredPE20	PE20	GB
2008-12-31	Be: patent expiredExpiredBE20	BE20	EP
2008-12-15	Patent ceasedCeasedPL	PL	CH
2008-07-25	Opposition data, opponent's data or that of the opponent's representative modifiedOppositionORIGINAL CODE: 0009299OPPOPLAB	PLAB	EP
2008-05-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-05-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-04-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-04-30	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-03-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-03-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-02-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-02-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-02-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-01-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2008-01-31	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2006-12-29	Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP	PGFP	EP
2005-12-09	Fr: translation filed ** decision concerning oppositionOppositionET3	ET3	EP
2005-10-05	Appeal reference modifiedAppealORIGINAL CODE: EPIDOSCREFNOAPAH	APAH	EP
2005-06-16	Patent modifiedDC2A	DC2A	ES
2005-05-02	Nl: receipt of modified translations in the netherlands language after an opposition procedureOppositionNLR3	NLR3	EP
2005-03-28	Ep patent validated in greeceEP	EP	GR
2005-03-15	Ep patent has been republished in amended form after opposition at epoOppositionRPEO	RPEO	SE
2005-01-03	Nl: decision of oppositionOppositionNLR2	NLR2	EP
2004-12-15	Scope or validity of the patent modifiedAUFRECHTERHALTUNG DES PATENTES IN GEAENDERTER FORMAEN	AEN	CH
2004-11-24	Patent maintained in amended form27A	27A	EP
2004-11-24	Designated contracting statesAK	AK	EP
2004-10-08	Patent maintained in amended formORIGINAL CODE: 0009272PUAH	PUAH	EP
2004-10-08	Information on the status of an ep patent application or granted ep patentGrantedSTATUS: PATENT MAINTAINED AS AMENDEDSTAA	STAA	EP
2004-02-25	Appeal procedure closedAppealORIGINAL CODE: EPIDOSNNOA9OAPBU	APBU	EP
2002-10-30	Appeal dossier modifiedAppealORIGINAL CODE: EPIDOS NOAPOAPAC	APAC	EP
2002-02-22	Appeal dossier modifiedAppealORIGINAL CODE: EPIDOS NOAPOAPAC	APAC	EP
2002-01-01	European patent in force as of 2002-01-01IF02	IF02	GB
2001-12-19	Appeal dossier modifiedAppealORIGINAL CODE: EPIDOS NOAPOAPAC	APAC	EP
2000-12-04	Appeal reference modifiedAppealORIGINAL CODE: EPIDOS REFNOAPAE	APAE	EP
2000-11-30	Appeal reference modifiedAppealORIGINAL CODE: EPIDOS REFNOAPAE	APAE	EP
2000-11-24	Appeal dossier modifiedAppealORIGINAL CODE: EPIDOS NOAPOAPAC	APAC	EP
2000-09-13	Interlocutory decision in oppositionOppositionORIGINAL CODE: EPIDOS IDOPPLAW	PLAW	EP
1999-07-16	Change of addressCA	CA	FR
1999-07-01	Nl: modifications (of names), taken from the european patent patent bulletinNLT2	NLT2	EP
1999-05-19	Party data changed (patent owner data changed or rights of a patent transferred)RAP2	RAP2	EP
1999-05-14	Name/firm changedGENE SHEARS PTY LIMITED,SUITE 1, BUILDING 5, 105 DELHI ROAD,NORTH RYDE, NSW 2113 (AU) TRANSFER- GENE SHEARS PTY LIMITED,ADMINISTRATION BUILDING CNR BARRY DRIVE-CLUNIES ROSS STREET GPO BOX 1600,CANBERRA, ACT 2601 (AU)PFA	PFA	CH
1998-08-28	Change of addressCA	CA	FR
1997-07-01	Nl: modifications (of names), taken from the european patent patent bulletinNLT2	NLT2	EP
1997-05-21	Party data changed (patent owner data changed or rights of a patent transferred)RAP2	RAP2	EP
1997-05-15	Name/firm changedGENE SHEARS PTY LTD,154 PACIFIC HIGHWAY, LEVEL 2,ST. LEONARDS/NSW (AU) TRANSFER- GENE SHEARS PTY LIMITED,SUITE 1, BUILDING 5, 105 DELHI ROAD,NORTH RYDE, NSW 2113 (AU)PFA	PFA	CH
1996-07-18	Reply of patent proprietor to notice(s) of oppositionOppositionORIGINAL CODE: EPIDOS OBSOPLBF	PLBF	EP
1996-05-03	Reply of patent proprietor to notice(s) of oppositionOppositionORIGINAL CODE: EPIDOS OBSOPLBF	PLBF	EP
1996-03-29	Reply of patent proprietor to notice(s) of oppositionOppositionORIGINAL CODE: EPIDOS OBSOPLBF	PLBF	EP
1996-01-02	Nl: opposition has been filed with the epoOppositionNLR1	NLR1	EP
1995-11-15	Opposition filedOpposition26	26	EP
1995-09-28	Opposition filedOppositionORIGINAL CODE: 0009260PLBI	PLBI	EP
1995-05-31	Validation in greece3015374FG4A	FG4A	GR
1995-03-17	Fr: translation filedET	ET	EP
1995-03-01	Definitive protectionFG2A	FG2A	ES
1995-02-02	Corresponds to:REF	REF	EP
1995-01-05	It: translation for a ep patent filedITF	ITF	EP
1995-01-05	It: translation for a ep patent filedITF	ITF	EP
1994-12-21	Designated contracting statesAK	AK	EP
1994-12-21	Corresponds to:REF	REF	EP
1994-11-04	(expected) grantORIGINAL CODE: 0009210GRAA	GRAA	EP
1994-09-21	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1	EP
1991-01-02	First examination report despatched17Q	17Q	EP
1990-09-12	Party data changed (applicant data changed or rights of an application transferred)RAP1	RAP1	EP
1990-05-30	Request for examination filed17P	17P	EP
1990-01-10	Designated contracting statesAK	AK	EP
1989-11-22	Search report despatchedORIGINAL CODE: 0009013PUAL	PUAL	EP
1989-06-21	Designated contracting statesAK	AK	EP
1989-05-06	Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI	PUAI	EP

Ribozymes

Abstract

Term

Priority claims25

Members54

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Events

Numbers

Titles3

Classification

Designated states13