Use of linear annelated tricyclics as inhibitors of erythrocyte aggregation
Abstract
Use of linearly fused tricyclic compounds of general formula I.in which R represents an optionally substituted phenyl ring or an optionally substituted heterocyclic five - membered ring containing from 1 to 4 heteroatoms, wherein the heteroatoms may be the same or different and denote oxygen, sulfur or nitrogen and, if desired, at one or several nitrogen atoms can carry one oxygen atom,or in the event that X represents a bond, R, in addition to the abovementioned groups, also a hydrogen atom, an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, haloalkyl, alkoxyalkyl, carboxyalkyl, alkoxy, carbonylalkyl, a hydroxy, mercapto, amino, alkylmercapto,Formylaminoalkyl, or a pyridylcarbonylamino group,X represents a bond, an alkylene, or the vinylene group,A may be a nitrogen atom or the group CRs, where R5 represents a hydrogen atom, an alkyl, alkenyl, cycloalkyl, cycloalkenyl, cyano, alkylcarbonyl, alkoxycarbonyl, carboxy, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl or aryl group,B is an oxygen atom, a sulfur atom or the group NR6 means, wherein R6 is a hydrogen atom or an alkyl group, or B is the group CR7R8th can be, where R7 represents a hydrogen atom, an alkyl, alkenyl, or a cycloalkyl group, and R8th a hydrogen atom, an alkyl, alkenyl or cyano group, a carbonyl group substituted by a hydroxy, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino group, or R7 and R8th together form an alkylidene or cycloalkylidene group, or R7 and R8th together with the carbon atom to which they are attached form a spirocycle,and their pharmacologically acceptable salts for the treatment of diseases in which the erythrocyte aggregation plays an important role in the pathogenesis.

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1 sheet
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Every citation, both ways
| Document | Relation | Office | Cited during |
|---|---|---|---|
| EP0161632A2 | Cites | European Patent Office (EPO) | Search report |
| EP0186010A1 | Cites | European Patent Office (EPO) | Search report |
| EP0189103A2 | Cites | European Patent Office (EPO) | Search report |
| EP0207483A2 | Cites | European Patent Office (EPO) | Search report |
| EP0214592A2 | Cites | European Patent Office (EPO) | Search report |
| EP0216165A1 | Cites | European Patent Office (EPO) | Search report |
13 members in 10 offices
Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 3740985 | Germany | A | |
| 3740985 | Germany | A | |
| 3740985 | Germany | – | |
| DE19873740985 | – | – | – |
Members13
| Document | Office | Kind | |
|---|---|---|---|
| DK666388D0 | Denmark | D0 | |
| DK666388A | Denmark | A | |
| EP0318902A2 | European Patent Office (EPO) | A2 | |
| AU2650688A | Australia | A | |
| DE3740985A1 | Germany | A1 | |
| IL88533A0 | Israel | A0 | |
| KR890009404A | Republic of Korea | A | |
| JPH01193219A | Japan | A | |
| ZA888880B | South Africa | B | |
| HUT51486A | Hungary | A | |
| EP0318902A3This record | European Patent Office (EPO) | A3 | |
| US4981864A | United States of America | A | |
| AU616620B2 | Australia | B2 |
8 legal events, as the office reported them to INPADOC
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| Application deemed to be withdrawnWithdrawn18D | 18D | |
| Information on the status of an ep patent application or granted ep patentGrantedSTATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWNSTAA | STAA | |
| First examination report despatched17Q | 17Q | |
| Designated contracting statesAK | AK | |
| Search report despatchedORIGINAL CODE: 0009013PUAL | PUAL | |
| Request for examination filed17P | 17P | |
| Designated contracting statesAK | AK | |
| Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI | PUAI |
Numbers
- Publication
- 0318902
- Publication, DOCDB
- 0318902
- Publication, EPODOC
- EP0318902
- Application
- 119839
- Application, DOCDB
- 88119839
- Application, EPODOC
- EP19880119839
Titles3
- German
- Verwendung linear anellierter Tricyclen als Hemmer der Erythrozytenaggregation
- English
- Use of linear annelated tricyclics as inhibitors of erythrocyte aggregation
- French
- Utilisation des tricycles linéairement annelés comme inhibiteurs de l'aggrégation des érythrocytes
Classification
- CPC, 17
- A61K31/44
- A61K31/54
- A61K31/40
- A61K31/415
- A61K31/42
- A61K31/425
- A61K31/50
- A61P1/04
- A61P3/08
- A61P17/00
- A61P7/02
- A61P25/02
- A61P9/00
- A61P29/00
- A61P9/08
- A61P35/00
- A61P9/10
- IPC, 20
- A61K31 40
- A61K31 41
- A61K31 415
- A61K31 42
- A61K31 425
- A61K31 44
- C07D487 04
- A61K31 50
- A61P1 04
- A61P3 08
- A61P7 02
- A61P9 00
- A61P9 08
- A61P9 10
- A61P17 00
- A61P25 02
- A61P29 00
- A61P35 00
- C07D498 04
- C07D513 04
Designated states13
- Contracting states, 13
- Austria
- Belgium
- Switzerland
- Germany
- Spain
- France
- United Kingdom
- Greece
- Italy
- Liechtenstein
- Luxembourg
- Netherlands (Kingdom of the)
- Sweden