EP0311368A3
Methods and apparatus for the quantitation of nuclear proteins
Abstract
A method of measuring the quantity of a specific nuclear protein in a cell/population, particularly in order to predict the prognosis of endocrine manipulative management in treating a carcinoma, comprises staining a sample of the cell population with at least one image enhancement factor which has an optical density which varies with the quantity of nuclear protein contained within said sample; measuring the optical density of said sample; and calibrating the measured optical density of said sample to the quantity of nuclear protein contained within said sample. An apparatus for carrying out the method is also disclosed.
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Every citation, both waysCites: the store holds 3 of 4
| Document | Relation | Office | Category | Cited during |
|---|---|---|---|---|
| EP0204922A2 | Cites | European Patent Office (EPO) | X | Search report |
| US4232001A | Cites | United States of America | X | Search report |
| WO8706705A1 | Cites | World Intellectual Property Organization (WIPO) | XP | Search report |
| International Journal of Gynecological Pathology, Vol. 5, No. 2, 1986, pages 119-131, Raven Press, New York, US; C. CHARPIN et al.: "Estrogen receptor immunocytochemical assay (ER-ICA) in human endometrium". | Non-patent | – | – | Search report |
| Cancer Research, Vol. 45, January 1985, pages 293-304; W.J. KING et al.: "Comparison of immunocytochemical and steroid-binding assays for estrogen receptor in human breast tumors". | Non-patent | – | – | Search report |
| Proc. Natl. Acad. Sci. USA, Vol. 82, July 1985, pages 4803-4807; A. SHIMADA et al.: "Immunocytochemical staining of estrogen receptor in paraffin sections of human breast cancer by use of monoclonal antibody: Comparison with that in frozen sections". | Non-patent | – | – | Search report |
| Arch. Pathol. Lab. Med., Vol. 109, August 1985, pages 716-721; K.S. McCARTY et al.: "Estrogen receptor analysis". | Non-patent | – | – | Search report |
| Am. J. Pathol., Vol. 123, No. 2, 1986, pages 280-292; M.F. PRESS et al.: "Estrogen receptor localization in the female genital tract". | Non-patent | – | – | Search report |
| Ann. Pathol., Vol. 8, No. 3, 1988, pages 196-210, Masson, Paris, FR; C. CHARPIN et al.: "Detection immunohistochimique de recepteurs oestrogeniques et analyse d'image (SAMBA 200) dans les carcinomes mammaires". | Non-patent | – | – | Search report |
| The Journal of Histochemistry and Cytochemistry, Vol. 35, No. 11, 1987, pages 1253-1259, The Histochemical Soc. Inc., US; R.J. SKLAREW et al.: "Quantitation of the immunocytochemical assay for estrogen receptor protein (ER-ICA) in human breast cancer by television imaging". | Non-patent | – | – | Search report |
| International Journal of Gynecological Pathology, Vol. 7, No. 1, 1988, pages 75-78, Raven Press Ltd., New York, US; J. KUPRYJANCZYK et al.: "Estrogen receptor distribution in the normal and pathologically changed human cervix uteri: An immunohistochemical study with use of monoclonal anti-ER antibody". | Non-patent | – | – | Search report |
| Am. J. Clin. Pahthol., Vol. 90, No. 2, 1988, pages 137-142; H.J. HELIN et al.: "Immunocytochemical detection of estrogen and progesterone receptors in 124 human breast cancers". | Non-patent | – | – | Search report |
| Cancer Research, Vol. 48, No. 15, August 1, 1988, pages 4368-4374; C. CHARPIN et al.: "Multiparametric evaluation (SAMBA) of growth fraction (monoclonal Ki67) in breast carcinoma tissue sections". | Non-patent | – | – | Search report |
| Proceedings of the 10th Symposium on Computer Applications in Medical Care, 25-26 October 1986, Washington, DC, US, pages 240-256, IEEE, New York, US; R.A. ROBB et al.: "A workstation for interactive display and quantitative analysis of 3-D and 4-D biomedical images". | Non-patent | – | – | Search report |
| T.Y. YOUNG et al., Handbook of Pattern Recognition and Image Processing, Chapter 26, "Biomedical Image Analysis", 1986, pages 629-647, Academic Press, London, GB; | Non-patent | – | – | Search report |
80 members in 8 offices
Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 106717 | United States of America | – | |
| 10671787 | United States of America | A | |
| 10671787 | United States of America | A | |
| US19870106717 | – | – | – |
Members80
| Document | Office | Kind | |
|---|---|---|---|
| WO8702802A1 | World Intellectual Property Organization (WIPO) | A1 | |
| WO8702803A1 | World Intellectual Property Organization (WIPO) | A1 | |
| EP0245466A1 | European Patent Office (EPO) | A1 | |
| EP0248840A1 | European Patent Office (EPO) | A1 | |
| US4741043A | United States of America | A | |
| JPS63501597A | Japan | A | |
| EP0311368A2 | European Patent Office (EPO) | A2 | |
| EP0314293A2 | European Patent Office (EPO) | A2 | |
| JPH01123153A | Japan | A | |
| JPH01127956A | Japan | A | |
| EP0317139A2 | European Patent Office (EPO) | A2 | |
| JPH01165958A | Japan | A | |
| US4887892A | United States of America | A | |
| EP0245466A4 | European Patent Office (EPO) | A4 | |
| EP0248840A4 | European Patent Office (EPO) | A4 | |
| EP0314293A3 | European Patent Office (EPO) | A3 | |
| EP0317139A3 | European Patent Office (EPO) | A3 | |
| CA2045172A1 | Canada | A1 | |
| CA2045614A1 | Canada | A1 | |
| WO9010276A1 | World Intellectual Property Organization (WIPO) | A1 | |
| WO9010277A1 | World Intellectual Property Organization (WIPO) | A1 | |
| US4998284A | United States of America | A | |
| US5008185A | United States of America | A | |
| US5016283A | United States of America | A | |
| US5018209A | United States of America | A | |
| EP0311368A3This record | European Patent Office (EPO) | A3 | |
| EP0460071A1 | European Patent Office (EPO) | A1 | |
| US5086476A | United States of America | A | |
| US5109429A | United States of America | A | |
| US5134662A | United States of America | A | |
| EP0534948A4 | European Patent Office (EPO) | A4 | |
| CA1312263C | Canada | C | |
| CA1312276C | Canada | C | |
| EP0460071A4 | European Patent Office (EPO) | A4 | |
| JPH05501151A | Japan | A | |
| EP0534948A1 | European Patent Office (EPO) | A1 | |
| US5202931A | United States of America | A | |
| EP0248840B1 | European Patent Office (EPO) | B1 | |
| DE3688330D1 | Germany | D1 | |
| DE3688330T2 | Germany | T2 | |
| EP0571053A2 | European Patent Office (EPO) | A2 | |
| US5272759A | United States of America | A | |
| US5281517A | United States of America | A | |
| CA1326601C | Canada | C | |
| EP0245466B1 | European Patent Office (EPO) | B1 | |
| DE3689856D1 | Germany | D1 | |
| US4741043B1 | United States of America | B1 | |
| DE3689856T2 | Germany | T2 | |
| EP0314293B1 | European Patent Office (EPO) | B1 | |
| DE3853254D1 | Germany | D1 | |
| EP0571053A3 | European Patent Office (EPO) | A3 | |
| JPH07146289A | Japan | A | |
| DE3853254T2 | Germany | T2 | |
| JPH07168102A | Japan | A | |
| JPH07181179A | Japan | A | |
| EP0317139B1 | European Patent Office (EPO) | B1 | |
| JPH07111425B2 | Japan | B2 | |
| DE3854644D1 | Germany | D1 | |
| US5485527A | United States of America | A | |
| EP0709667A2 | European Patent Office (EPO) | A2 | |
| DE3854644T2 | Germany | T2 | |
| US5541064A | United States of America | A | |
| EP0311368B1 | European Patent Office (EPO) | B1 | |
| JP2527536B2 | Japan | B2 | |
| DE3855472D1 | Germany | D1 | |
| DE3855472T2 | Germany | T2 | |
| EP0534948B1 | European Patent Office (EPO) | B1 | |
| AT153154T | Austria | T | |
| ATE153154T1 | Austria | T1 | |
| DE69030733D1 | Germany | D1 | |
| ES2100882T3 | Spain | T3 | |
| CA2045614C | Canada | C | |
| EP0709667A3 | European Patent Office (EPO) | A3 | |
| DE69030733T2 | Germany | T2 | |
| CA2045172C | Canada | C | |
| EP0245466B2 | European Patent Office (EPO) | B2 | |
| EP0571053B1 | European Patent Office (EPO) | B1 | |
| DE3650786D1 | Germany | D1 | |
| DE3689856T3 | Germany | T3 | |
| DE3650786T2 | Germany | T2 |
33 legal events, as 2 offices reported them to INPADOC
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|---|---|---|---|
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Se: european patent has lapsedLapsedEUG | EUG | EP | |
| Nl: ceased due to reaching the maximum lifetime of a patentCeasedNLV7 | NLV7 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Be: patent expiredExpiredBE20 | BE20 | EP | |
| Patent expired after termination of 20 yearsExpiredPE20 | PE20 | GB | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| European patent in force as of 2002-01-01IF02 | IF02 | GB | |
| No opposition filedOpposition26N | 26N | EP | |
| No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE | PLBE | EP | |
| Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA | STAA | EP | |
| It: translation for a ep patent filedITF | ITF | EP | |
| It: translation for a ep patent filedITF | ITF | EP | |
| Fr: translation filedET | ET | EP | |
| Corresponds to:REF | REF | EP | |
| Designated contracting statesAK | AK | EP | |
| (expected) grantORIGINAL CODE: 0009210GRAA | GRAA | EP | |
| Despatch of communication of intention to grant a patentORIGINAL CODE: EPIDOS IGRAGRAH | GRAH | EP | |
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| Party data changed (applicant data changed or rights of an application transferred)RAP1 | RAP1 | EP | |
| First examination report despatched17Q | 17Q | EP | |
| Request for examination filed17P | 17P | EP | |
| Main classification (correction)RHK1 | RHK1 | EP | |
| Designated contracting statesAK | AK | EP | |
| Search report despatchedORIGINAL CODE: 0009013PUAL | PUAL | EP | |
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| Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI | PUAI | EP |
Numbers
- Publication
- 0311368
- Publication, DOCDB
- 0311368
- Publication, EPODOC
- EP0311368
- Application
- 309264
- Application, DOCDB
- 88309264
- Application, EPODOC
- EP19880309264
Titles3
- German
- Verfahren und Vorrichtung zur Quantifizierung von Nuklearproteinen
- English
- Methods and apparatus for the quantitation of nuclear proteins
- French
- Procédé et dispositif pour la quantification des protéines nucléaires
Classification
- CPC, 15
- G06V20/69
- G01N15/1433
- G01N1/30
- G01N21/6458
- G01N33/68
- G01N33/743
- G01N2201/127
- Y10S436/813
- Y10S435/808
- Y10S436/807
- Y10S436/817
- Y10S436/805
- G01N2474/20
- G01N33/57515
- G01N33/57575
- IPC, 9
- G01N15 14
- G01N33 48
- G01N33 53
- G01N33 574
- G01N33 577
- G01N1 30
- G01N33 68
- G01N33 74
- G06K9 00
Designated states1
- Contracting states, 1
- Sweden