EP0241918A3

1-hydroxy-2-pyridinones, process for their preparation and medicines containing them, as well as intermediates formed by the preparation of 1-hydroxy-2-pyridinones

Abstract

New 1-hydroxy-2-pyridones of the general formula I in which mean<br />R¹, R² and R³, which are the same or different, are hydrogen or lower alkyl of 1-4 carbon atoms wherein R¹ and R³ are preferably hydrogen and R² is preferably methyl,<br />XS or preferably O,<br />Y is hydrogen or up to 2 halogen atoms, namely chlorine and / or bromine,<br />Z is a single bond or the divalent radicals O, S, -CR₂- (R = H or C₁-C₄-alkyl) or other 2-valent radicals having 2-10 chain-linked C and optionally O and / or S atoms, where - if the radicals contain 2 or more O and / or S atoms - the latter are separated from one another by at least 2 C atoms and in which 2 adjacent C atoms can also be linked to one another by a double bond and the free valencies of the C atoms Atoms are saturated by H and / or C₁-C₄-alkyl groups,<br />Ar is an aromatic ring system having up to two rings, which may be substituted by up to three radicals from the group of fluorine, chlorine, bromine, methoxy, C₁-C₄-alkyl, trifluoromethyl and trifluoromethoxy,<br />are produced according to different process variants. The compounds and their physiologically acceptable salts with inorganic or organic bases are mainly antimycotic, antibacterial and antiviral effective. Also, the compounds of the formula V occurring in the preparation of the compounds of formula I wherein R¹, R², R³, X, Y and Ar have the same meaning as in formula I,<br />are new.

EP0241918A3, drawing sheet 1
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Projected expiry passed 14 April 2007, 19.4 years ago.

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