1-hydroxy-2-pyridinones, process for their preparation and medicines containing them, as well as intermediates formed by the preparation of 1-hydroxy-2-pyridinones
Abstract
New 1-hydroxy-2-pyridones of the general formula I in which mean<br />R¹, R² and R³, which are the same or different, are hydrogen or lower alkyl of 1-4 carbon atoms wherein R¹ and R³ are preferably hydrogen and R² is preferably methyl,<br />XS or preferably O,<br />Y is hydrogen or up to 2 halogen atoms, namely chlorine and / or bromine,<br />Z is a single bond or the divalent radicals O, S, -CR₂- (R = H or C₁-C₄-alkyl) or other 2-valent radicals having 2-10 chain-linked C and optionally O and / or S atoms, where - if the radicals contain 2 or more O and / or S atoms - the latter are separated from one another by at least 2 C atoms and in which 2 adjacent C atoms can also be linked to one another by a double bond and the free valencies of the C atoms Atoms are saturated by H and / or C₁-C₄-alkyl groups,<br />Ar is an aromatic ring system having up to two rings, which may be substituted by up to three radicals from the group of fluorine, chlorine, bromine, methoxy, C₁-C₄-alkyl, trifluoromethyl and trifluoromethoxy,<br />are produced according to different process variants. The compounds and their physiologically acceptable salts with inorganic or organic bases are mainly antimycotic, antibacterial and antiviral effective. Also, the compounds of the formula V occurring in the preparation of the compounds of formula I wherein R¹, R², R³, X, Y and Ar have the same meaning as in formula I,<br />are new.

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Every citation, both ways
| Document | Relation | Office | Category | Cited during |
|---|---|---|---|---|
| DE2214608A1 | Cites | Germany | A | Search report |
| DE2234009A1 | Cites | Germany | AD | Search report |
46 members in 22 offices
Priority claims10
| Document | Office | Kind | Date |
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| 3613061 | Germany | A | |
| 3613061 | Germany | A | |
| 3613061 | Germany | – | |
| 3626211 | Germany | A | |
| 3626211 | Germany | A | |
| 3626211 | Germany | – | |
| 3613061 | – | – | – |
| 3626211 | – | – | – |
| DE19863613061 | – | – | – |
| DE19863626211 | – | – | – |
Members46
| Document | Office | Kind | |
|---|---|---|---|
| DK198387D0 | Denmark | D0 | |
| NO871602D0 | Norway | D0 | |
| FI871699A0 | Finland | A0 | |
| PT84702A | Portugal | A | |
| IE871009L | Ireland | L | |
| DK198387A | Denmark | A | |
| FI871699A | Finland | A | |
| FI871699A7 | Finland | A7 | |
| NO871602L | Norway | L | |
| EP0241918A2 | European Patent Office (EPO) | A2 | |
| AU7171787A | Australia | A | |
| DE3613061A1 | Germany | A1 | |
| IL82231A0 | Israel | A0 | |
| IL82231D0 | Israel | D0 | |
| JPS62249974A | Japan | A | |
| KR870010001A | Republic of Korea | A | |
| HUT43824A | Hungary | A | |
| ZA872745B | South Africa | B | |
| DE3626211A1 | Germany | A1 | |
| ATA258387A | Austria | A | |
| US4797409A | United States of America | A | |
| EP0241918A3This record | European Patent Office (EPO) | A3 | |
| AT388551B | Austria | B | |
| HU198020B | Hungary | B | |
| NZ220020A | New Zealand | A | |
| PT84702B | Portugal | B | |
| PH24106A | Philippines | A | |
| AU602684B2 | Australia | B2 | |
| JPH03864B2 | Japan | B2 | |
| IL82231A | Israel | A | |
| EP0241918B1 | European Patent Office (EPO) | B1 | |
| CA1302415C | Canada | C | |
| AT76638T | Austria | T | |
| ATE76638T1 | Austria | T1 | |
| FI86635B | Finland | B | |
| DE3779352D1 | Germany | D1 | |
| NO170540B | Norway | B | |
| FI86635C | Finland | C | |
| NO170540C | Norway | C | |
| AR242187A1 | Argentina | A1 | |
| GR3005465T3 | Greece | T3 | |
| DK167494B1 | Denmark | B1 | |
| ES2041656T3 | Spain | T3 | |
| MX6093A | Mexico | A | |
| IE59965B1 | Ireland | B1 | |
| KR950007754B1 | Republic of Korea | B1 |
43 legal events, as 5 offices reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | Office | |
|---|---|---|---|
| Be: patent expiredExpiredBE20 | BE20 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Announcement of lapse in spainLapsedFD2A | FD2A | ES | |
| Se: european patent has lapsedLapsedEUG | EUG | EP | |
| Nl: ceased due to reaching the maximum lifetime of a patentCeasedNLV7 | NLV7 | EP | |
| Patent ceasedCeasedPL | PL | CH | |
| Patent expired after termination of 20 yearsExpiredPE20 | PE20 | GB | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Lapsed in a contracting state [announced via postgrant information from national office to epo]LapsedPG25 | PG25 | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| Annual fee paid to national office [announced via postgrant information from national office to epo]GrantedPGFP | PGFP | EP | |
| European patent in force as of 2002-01-01IF02 | IF02 | GB | |
| Se: european patent in force in swedenEAL | EAL | EP | |
| Lu: last paid annual feeEPTA | EPTA | EP | |
| Definitive protectionFG2A | FG2A | ES | |
| No opposition filedOpposition26N | 26N | EP | |
| No opposition filed within time limitOppositionORIGINAL CODE: 0009261PLBE | PLBE | EP | |
| Information on the status of an ep patent application or granted ep patentGrantedSTATUS: NO OPPOSITION FILED WITHIN TIME LIMITSTAA | STAA | EP | |
| Validation in greece3005465FG4A | FG4A | GR | |
| Gb: translation of ep patent filed (gb section 77(6)(a)/1977)GBT | GBT | EP | |
| Fr: translation filedET | ET | EP | |
| It: translation for a ep patent filedITF | ITF | EP | |
| It: translation for a ep patent filedITF | ITF | EP | |
| Corresponds to:REF | REF | EP | |
| Designated contracting statesAK | AK | EP | |
| Corresponds to:REF | REF | EP | |
| (expected) grantORIGINAL CODE: 0009210GRAA | GRAA | EP | |
| First examination report despatched17Q | 17Q | EP | |
| Request for examination filed17P | 17P | EP | |
| Designated contracting statesAK | AK | EP | |
| Search report despatchedORIGINAL CODE: 0009013PUAL | PUAL | EP | |
| Designated contracting statesAK | AK | EP | |
| Public reference made under article 153(3) epc to a published international application that has entered the european phaseORIGINAL CODE: 0009012PUAI | PUAI | EP |
Numbers
- Publication
- 0241918
- Publication, DOCDB
- 0241918
- Publication, EPODOC
- EP0241918
- Application
- 87105537
- Application, DOCDB
- 87105537
- Application, EPODOC
- EP19870105537
Titles3
- German
- 1-Hydroxy-2-pyridone, Verfahren zu ihrer Herstellung und Arzneimittel, die sie enthalten, sowie bei der Herstellung der 1-Hydroxy-2-pyridone gebildete Zwischenprodukte
- English
- 1-Hydroxy-2-pyridinones, process for their preparation and medicines containing them, as well as intermediates formed by the preparation of 1-hydroxy-2-pyridinones
- French
- Hydroxy-1-pyridin-2-ones, procédé pour leur préparation et médicaments qui les contiennent de même que des intermédiaires formés lors de la préparation des hydroxy-1-pyridin-2-ones
Classification
- CPC, 2
- C07D213/89
- C07D309/38
- IPC, 3
- A61K31 44
- C07D213 89
- C07D309 38
Designated states1
- Contracting states, 1
- Sweden