Nova Patents
EP0215313B1

Emulsion compositions for the parenteral and/or oral administration of sparingly water soluble ionizable hydrophobic drugs

Abstract

This record has no abstract on file.

EP0215313B1, drawing sheet 1
Sheet 1 of 8

Term

Term ended

Expired 19 August 2006, 20.1 years ago.

  1. Priority
  2. Filed
  3. Granted
  4. Expired
  5. Today

7 claims: 1 independent, 6 dependent

  1. 1
    A pharmaceutical composition for delivery of hydrophobic drugs comprising:(a) a hydrophobic drug Bis(2-imidazol-2-yl hydrazone)-9,10-anthracenedicarboxaldehyde or 3-[4,6-bis[(1,1,2,2,-tetramethyl-propyl)amino]-s-triazin-2-yl]-3-azabicyclo [3,2,2] nonane;(b) a pharmaceutically acceptable oleaginous vehicle selected from sesame oil, peanut oil, olive oil, safflower oil, soybean oil, benzyl benzoate, mono, di or triglycerides;(c) a surfactant selected from egg or soy lecithins, egg or soy phospholipids, egg phosphatidyl ethanolamine, phosphatidic acid, plant monogalactosyl diglyceride (hydrogenated), plant digalactosyl diglyceride, dihexanoyl-L-α-lecithin dioctanoyl-L-α-lecithin, didecanoyl-L-α-lecithin, didodecanoyl-L-α-lecithin, ditetradecanoyl-L-α-lecithin, dihexadecanoyl-L-α-lecithin, dioctadecanoyl-L-α-lecithin, dioleoyl-L-α-lecithin, dilinoleoyl-L-α-lecithin, α-palmito, β-oleoyl-L-α-lecithin, L-α-glycerophosphoryl choline, sorbitan triisostearate, triglycerol diisosterate, triglycerol or surfactants based on polyoxyethylated hydrocarbons or vegetable oils;(d) a co-surfactant selected from saturated or unsaturated aliphatic acids, carproic, enathic, caprylic, capric, lauric, palmitic, stearic arachidonic, arachidic, oleic, linoleic, or linolenic;(e) benzyl alcohol as a co-solvent;(f) optionally, a cryoprotectant or toxicity modifier selected from glycerol, lactose, or mannitol or an antioxident such as d,l-α-tocopherol or an emulsion stabilizer;(g) water.