Treating lignocellulosic materials

It is a method for significantly reducing the region width in daily dosages required to control pain in approximately 80% of patients disclosed, wherein an oral solid dosage formulation with controlled release comprising about 10 to about 40 mg oxycodone or a salt thereof to a patient is administered. The formulation provides a mean of about 2 to about 4.5 hours after administration, a mean maximum plasma concentration of oxycodone from about 6 to about 60 ng / ml, and an average of from about 10 to about 14 hours after repeated "q12h" ( ie, every 12 hours) administration of a mean minimum plasma concentration from about 3 to about 30 ng / ml at steady state conditions. Another embodiment relates to a method for significantly reducing the region width in daily dosages required to control pain in substantially all patients. Fig. 5 is a graph showing the mean plasma oxycodone concentration of a 10 mg oxycodone controlled-release formulation as well as a Studienrefenzstandard, wherein the formulation was prepared according to the present invention.