Pharmaceutical formulations for the sustained release of one or more active principles and therapeutic applications thereof

The invention relates to novel, based on stable, a of a pasting a long buckled active ingredients, specifically a protein which active medicine formulation, the invention further claims the applications of said formulation, specifically application of therapeutics. Purpose of the invention claims a release of active agents to the liquid medicine formulation, the formula of the outer gastrointestinal hose, a display is a treating with a protein of the body the time, and reducing active protein blood plasma concentration top. Moreover, wherein and can be is stably, and biological is accommodating, and a biodegradable, and not of the immunity, and lower part tolerance. The invention formula based on connecting the hydrophobic group water-solubility a biodegradable polymer the lower viscosity hydrosol a of micro grains, wherein the particle non-covalence at least one active ingredient (AP) connected, and formed the gel heater object at the position injection part; the gel gelation gelling of the problem of the physiological medium's protein.