PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS

Wherein the compound having the formula or a pharmaceutically acceptable salt thereof, wherein R1 is a group of the formula wherein y is 0, 1 or 2; R4 is selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, ( C 1 -C 4) alkoxy, (C1-C6) acyloxy, (C1-C6) alkylamino, (C1-C6) alkyl) 2 amino, act, nitro, (C2-C6) alkenyl, (C2-C6) alkynyl or (C1- C6) acylamino, or R4 is (C3-C10) cycloalkyl wherein the cycloalkyl group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl, (C1-C6) acyloxy, (C1-C6) acylamino, (C1-C6) alkylamino, (C1-C6) alkyl) 2amino, cyano, cyano (C1-C6) alkyl, trifluoromethyl (C1-C6) alkyl, nitro, nitro (C1-C6) alkyl or (C1-C6) acylamino; R5 is selected from the group consisting of trifluoromethyl (C1-C6) alkyl, (C1-C3) alkyl (difluoromethylene) (C1-C3) alkyl, (C3-C10) cycloalkyl wherein the cycloalkyl group is optionally substituted by one to five carboxy, cyano, amino, deuterium, hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, halo, (C1-C6) acyl, (C1-C6) alkylamino, amino (C1-C6) alkyl, (C1-C6 ) alkoxy-CO-NH, (C1-C6) alkylamino-CO-, (C2C6) alkenyl, (C2-C6) alkynyl, (C1-C6) alkylamino, amino (C1-C6) alkyl, hydroxy (C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) alkyl, (C1-C6) acyloxy (C1-C6) alkyl, nitro, cyano (C1-C6) alkyl, halo (C1-C6) alkyl, nitro (C1- C6) alkyl, trifluoromethyl, trifluoromethyl (C1-C6) alkyl, (C1-C6) acylamino, (C1-C6) acylamino (C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) acylamino, amino (C1 C6) acyl, amino (C1-C6) acyl (C1-C6) alkyl, (C1-C6) alkylamino (C1-C6) acyl, (C1-C6) alkyl) 2amino (C1-C6) acyl, R15R16N-CO -O, R15R16N-CO- (C1-C6) alkyl, (C1 -C6) alkyl-S (O) m, R15R16NS (O) m, R15R16NS (O) m (C1-C6) alkyl, R15 (O) R15 MR16N (O) MR16N (C1-C6) alkyl wherein m is 0, 1 or 2 and R15 and R16 are each independently selected from hydrogen or (C1-C6) alkyl; or R5 is (C3-C10) cycloalkyl (C1-C6) alkyl, (C1C6) acyloxy (C1-C6) alkyl, (C2-C6) alkoxy (C1-C6) alkyl, piperazinyl (C1-C6) alkyl, (C1 C6) acylamino (C1-C6) alkyl, (C6-C10) aryl (C1-C6) alkoxy (C1-C6) alkyl, (C5-C9) heteroaryl (C1-C6) alkoxy (C1-C6) alkyl, (C1-C6) alkylthio (C1-C6) alkyl, (C6-C10) arylthio (C1-C6) alkyl, (C1-C6) alkylsulfonyl (C1-C6) alkyl, (C6-C10) arylsulfonyl, (C1-C6) alkyl, (C1-C6) alkylsulfonyl (C1-C6) alkyl, (C6-C10) arylsulfonyl, (C1-C6) alkyl, amino (C1-C6) alkyl, (C1-C6) alkylamino (C1-C6) alkyl, ( C1-C6) alkyl) 2 amino, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl wherein the alkyl, alkenyl or alkynyl groups are optionally substituted by one to five cyano, nitro, halo, deuterium , hydroxy, carboxy, (C1-C6) acylamino, (C1-C6) alkoxy (C1-C6) acylamino, amino (C1-C6) acyl, (C1-C6) alkylamino (C1-C6) acyl or (C1-C6 ) alkyl) 2amino (C1-C6) acyl; or R 5 is R 13 CO (C 1 -C 6) alkyl or R13CO (C3-C10) cycloalkyl wherein R13 is R20O or R20R21N wherein R20 and R21 are each independently selected from the group consisting of hydrogen, deuterium, (C1-C6) alkyl, (C6- C10) aryl (C1-C6) alkyl or (C5-C9) heteroaryl (C1-C6) alkyl; or R5 is R14, R14 (C1-C6)