Enhanced transdermal transport using ultrasound

(57) Some means for reinforcing 経皮 transportation of a summary medicine and an analysis thing were developed. The ultrasonic wave of low frequency, permeability and/or the chemical modifier of emasculation, the ion introducing method and/or electroporation (electric field), pressure and/or decompression (physical enhancer), and use of a magnetism place are included by this. Application of the ultrasonic wave of low frequency (about 20 kHz * 1 MHz) reinforces measurement of the concentration of 経皮 transportation of a medicine and the analysis thing in humors (for example, blood or lymph). Using the range and intensity of frequency of a wide range ultrasonic wave, by using the career (for example, リポソーム or particulates) to a medicine, delivery may be reinforced further or may be controlled. Particulates are small molecules preferably, have the surface accompanied by the hydrophile property or oleophilicity which increased, and can reinforce transportation further.