Eye-refreshing agent to eliminate and alleviate eye fatigue and discomfort

p0001A cancellation, relieve eye fatigue and eye discomfort FIELD cooling agents

p0002The present invention belongs to the field of pharmaceutical preparation technology, relates to a fresh natural medicinal plants as the raw material used to eliminate, alleviate eye fatigue and eye discomfort cooling agents, the present invention also relates to the eye cooling agents Preparation. Background technique

p0003Over the past decade with the fast-paced development of social life and the widespread use of the network, people with the eyes of a lot more time, especially online staff, IT industry professionals, long-distance passenger and truck drivers as well as students and other groups, since focus on the eye with prolonged time, visual fatigue has become a major factor affecting eye health. Currently the number of Internet users in the world every year in larger increments of only in the number of Internet users in China has more than 300 million Internet users each day has reached an average of eight hours or so, in addition to outside users, now Chief of Staff has entered computer office automation era, the average daily online office hours have been more than four hours, eye fatigue tend to affect productivity and lead to eye disease; and long-distance transport drivers average driving time is more than four hours, sometimes serious than 6 hours of continuous working time, a serious accident due to head the Ministry of Burgundy also cause visual fatigue frequently occur. For older people, for a long time with the eye and other ocular physiological function organic causes hair appears dry, astringent, ghosting, blurred vision and other eye aging phenomena occur physiologically dry, astringent and so also seriously affect their health and quality of life.

p0004Head unit Burgundy visual fatigue include eye strain and eye fatigue are two skin cells, both The result is a direct cause visual fatigue eye. The most direct expression of mesh portion Burgundy is dry eye visual fatigue, swelling, ghosting, blurred vision, eye rings of black, there will be serious bags under the eyes increases, decreased vision, increased eye Gen wrinkles and other phenomena. The conventional way to solve such problems is mainly used eye drops, thus increasing the moisture of the eye, but the eye can not resolve the problem of skin cells fatigue fundamentally, but also unable to effectively address the many elderly long-standing eye Ministry of physiological hair appears dry, astringent phenomenon.

p0005At home and abroad for the treatment of dry eyes and eye drops main moisturizing eye gel, etc., which are mainly eye drops antibiotic drugs, although anti-inflammatory, antibacterial effect, but can not play a relieve visual fatigue eye effect; and Run eye lotion moisturizer products are mainly a class of drugs has a moisturizing effect on the eye, but they can not relieve visual fatigue.

p0006Sales of ophthalmic drugs currently on the market, though has anti-inflammatory, antibacterial, moisturizing effect, but none of them take into account the drug long used to reduce the visual fatigue caused by eye Burgundy, not fresh eye problems. SUMMARY

p0007Object of the present invention is to solve the problems of the prior art, thereby providing a natural plant-utilization can be used to eliminate, alleviate eye fatigue and eye discomfort cooling agents, the cooling agents have mitigating and eye head unit Burgundy eliminate visual fatigue caused by dryness, swelling, ghosting, blurred vision, eye black rings of other conditions as well as older type of eye dry, astringent, itching phenomenon, but also promote eye skin cell metabolism, to improve the refreshing degree vision, prevention and elimination of visual fatigue, but also has the role of bags due to ease and improve the visual fatigue caused by eye wrinkles and other pseudo-section of Burgundy. Aspect of the present invention to solve the problems of the prior art and the use of the designer based on the analysis of data based on the pharmaceutical ingredient selected natural plant intended for human eye effect on skin cells, as well as through clinical administration of the drug on the eye relieve visual fatigue generated, foundation improvement of practical experience and knowledge on the obtained, it is a dedicated preparation prepared by techniques of modern biotechnology in remission, improve the human eye to eye skin due to longer lead to vision natural eye fatigue cooling agents. The agent is a refreshing eye germ green beans, eucalyptus, clove leaves, mint leaves, camphor, borneol as raw material for the dosage sprays, ointments, eye patch or a liquid eye several topical skin care agent, its raw material component consists of the following components of effective drug weight ratio is made:

p0008Mung bean germ extract was separated acoustic diaphragm 10 to 80,

p0009Eucalyptus leaves extract sound separation membrane 10 to 80,

p0010Mint leaf extract sound separation membrane 5 to 50,

p0011Clove leaf extract sound separation membrane 5 to 50,

p0012Camphor leaf extract sound membrane separation 1 to 10,

p0013Borneol 0.1 to 1,

p0014The method for preparing the ocular cooling agents include the following process steps:

p00151. Preparation of membrane separation mung bean germ extract sound: after fresh green beans and mixed germ rough cut 0.3 ~ 0.5 times the weight of water, mix: ^ text into the ultrasonic cell crusher, broken into serous cells, cell after the treatment the slurry centrifuged, then the supernatant was separated by the acoustic membrane separator, having a molecular weight of less than 6000D acoustic membrane separation bean germ extract;

p00162. Preparation of the acoustic membrane separation eucalyptus leaves extract: fresh eucalyptus leaves mechanically broken after adding 0.5 ~ 0.6 times the weight of water were mixed in: ^ text within the ultrasonic cell crusher, crushing Slurry into cells, the cells after centrifuging the slurry process, the supernatant then separated by the acoustic membrane separator to obtain a molecular weight less than 6000D eucalyptus leaf extract sound membrane separation;

p00173. Preparation of the acoustic membrane separation mint leaves extract: A Fresh mint leaves with broken machinery, added 0.5 ~ 0.6 times the weight of water were mixed in: ^ text into the ultrasonic cell crusher, broken into cells serous cells after centrifuging the slurry process, the supernatant was then separated by the sound of membrane separator to obtain a sound mint leaves membrane separation molecular weight less than 6000D extract;

p00184 Preparation, clove leaf extract sound membrane separation: after fresh clove leaf broken machinery, added 0.5 ~ 0.6 times the weight of water were mixed in: ^ text into the ultrasonic cell crusher, broken into cells serous cells after centrifuging the slurry process, the supernatant was then separated by the sound of membrane separator to obtain a molecular weight less than 6000D acoustic membrane separation of clove leaf extract;

p00195, camphor leaf extract sound membrane separation: After the fresh leaves of camphor mechanical break, adding 0.5 ~ 0.6 times the weight of water were mixed in: ^ text into the ultrasonic cell crusher, broken into cell slurry after centrifuging the cells treated slurry, and then the supernatant was separated by separator acoustic diaphragm having a molecular weight of less than 6000D camphorsulfonic YE separation membrane extract;

p0020After 6, each of the above-described membrane separation acoustic extract preparation were mixed in the range of 0 ~ 4 ° C were centrifuged, speed of centrifugation 3000rpm ~ 4000rpm, for 10 to 20 minutes, again after acoustic diaphragm separating and removing sediment, centrifugate It is to give the mixed sound separation membrane of molecular weight less than 6000D extract;

p00217, mixing sound mixing after separation membrane separating the extract is mixed with borneol, press sprays, ointments, eye patch or preparation of the agent will be prepared as sprays, ointments, eye patch or agent .

p0022In each active pharmaceutical ingredient of the present invention the cooling agents in the eye: mung bean germ has a clear Cool, detoxification, cell hydration effect, can enhance the eye skin cell metabolism and hydration capability; Eucalyptus leaves a cool, refreshing effect and hydration of cells, which can enhance the eye skin cell metabolism and hydration capacity ; clove leaf and mint leaves have a cool, refreshing effect, can promote eye skin cell metabolism; camphor and borneol, respectively, with a refreshing and refreshing effect.

p0023Eye of the present invention is the choice of cooling agents natural plant material and biological products prepared in accordance with the technical requirements made of mesh portion Burgundy skin care products, containing plant polysaccharides, polypeptides, cell hydration factor, menthol, camphor, clove a variety of active ingredients alcohol, borneol, etc., the above-mentioned active ingredient is a low molecular weight, easy to be absorbed through the skin eye with ease, eliminate eye fatigue visual effects, but also it has improved due to head the Ministry of Burgundy dry eye caused by a longer time , swelling, blurred vision, eye black rings of action, ghost, bags under the eyes, for the elderly appear eye wrinkles, bags under the eyes also has a role in the formation and prevent the formation of certain improvement, but also for age-related dry eye , astringent, itching phenomenon has significantly improved, alleviate and eliminate the role. In addition, since the eye refreshing agent selected substances are natural plant materials, no chemical synthetic drugs and endogenous substances allergies, nontoxic to humans, nor is there any side effects to the eye skin sensitization sexual stimulation, set efficacy and safety as a whole, it has a good use of promotional value.

p0024To show the present invention on the skin of the eye eye freshener fatigue and visual fatigue mitigation, cancellation, the present invention after several years of repeated application products research and trial practice (including the choice of visual fatigue eye dryness, swelling , ghosting, blurred vision, eye rings of black test status) study show that the eye cooling agents with a broad spectrum of visual eye fatigue ameliorating, alleviating, eliminating the role of reach fresh eye vision, visual attention set Increase the head unit Burgundy moist feeling effect, promote cell metabolism and enhance eye and enhance the capacity and capillary circulation. The development process, the effectiveness of cooling agents according to the present invention, the eye due to a long time with the eyes can cause eye fatigue-reducing conditions, relieve eye dryness, swelling, ghosting, blurred vision, eye black rings of degree standard, effective Basis eye health and eliminate visual fatigue elimination standards, nearly 500 people on the dosage form is spray usage of the eye skin care agents were visited daily dose of respondents use a spray, one dose at 0 . about 5ml, the statistical results are as follows:

p0025Statistical data for the 472, the effective rate was 100%, effective rate of 97%. detailed description

p0026Example

p0027The process for manufacturing the extraction solution mesh Gen-soluble portion of cooling agents are described below:

p00281, the fresh-cut green beans germ coarsely mixed with 0.4 times by weight of water, into the mixture ultrasonic cell crusher, crushing the slurry into the cells, the cells treated slurry through centrifuge (centrifugal rotation 3500rpm, 15 minutes ), the supernatant was then after the designer of the present invention developed patent No. ZL03262745. 6 acoustic membrane separator (hereinafter the same) were separated to give the cell molecular weight less than 6000D liquid (acoustic membrane separation mung bean germ extract) color is pale yellow or colorless liquid, containing polysaccharides plant components;

p00292, fresh eucalyptus leaves after breaking mechanically mixed with 0.5 times the weight of water, and the mixture placed in an ultrasonic cell crusher, broken into serous cells, cells treated slurry through centrifuge (centrifugal speed 3500rpm, time 15 minutes), the supernatant was then after the acoustic separation membrane separator was prepared to give a molecular weight of less than 6000D cells dope (eucalyptus acoustic diaphragm points From the extract), color is light green or colorless liquid, containing polysaccharides of plant components;

p00303, fresh mint leaves with broken machinery, added 0.5 times by weight of water were mixed in the text into the ultrasonic cell crusher, broken into serous cells, cells treated slurry through centrifuge (centrifugal speed 3500rpm, time 15 minutes), the supernatant was then separated by separator acoustic diaphragm having a molecular weight of less than 6000D cells liquid mint leaves (mint extract acoustic membrane separation), colorless or color is yellowish green liquid, containing plant menthol ingredients;

p00314, fresh clove leaf broken machinery, added 0.5 times the weight of water were mixed, and the mixture placed in an ultrasonic cell crusher, broken into serous cells, cells treated slurry through centrifuge (centrifugal speed 3500rpm, time 15 minutes), the supernatant was then separated by separator acoustic diaphragm having a molecular weight of less than 6000D liquid clove leaf cells (membrane separation sound clove extract), the color is colorless or yellowish green liquid, containing Ding mellow plant ingredients;

p00325, fresh camphor leaves broken machinery, added 0.5 times by weight of water were mixed in the text into the ultrasonic cell crusher, broken into serous cells, cells treated slurry through centrifuge (centrifugal speed 3500rpm, time 15 minutes), the supernatant was then separated by separator acoustic diaphragm having a molecular weight of less than 6000D leaf cells liquid camphor (camphor YE separation membrane extract), the color is colorless or yellowish green liquid, containing plants ingredients like camphor;

p00336, each of the cells take dope and borneol material allocation ratio according to the following configuration: mung bean germ extract sound membrane separation 5000g,

p0034Eucalyptus leaves sound membrane extract 5000 g, Mint leaf extract sound membrane separation 1 000 g,

p0035Clove leaf extract sound membrane separation 1 00 Og,

p0036Camphor leaf extract sound membrane separation 50 Og,

p0037Borneol 50g,

p00387, each of the above-described membrane separation acoustic extract preparation were mixed at a low temperature (0 ~ 4 ° C) conditions of high-speed centrifugation (centrifugation speed 3500rpm, 15 minutes), the residue was discarded, the supernatant retained, supernatant liquid membrane separation technique using sound to give the molecular weight of less than 6000D liquid separation;

p00398, the liquid will be mixed with ice flakes mixed cells separated after preparation according to the conventional spray will be prepared after the spray dispensing and packaging, ie finished.