Film-forming composition containing a sun filter, and use thereof for the treatment of scars

Film-forming composition containing a sunscreen, its use for the treatment of scars

The present invention relates to a liquid dressing containing at least one polymer, a plasticizer, a volatile solvent, and an organic sunscreen in very small quantities. This composition, intended to be applied to the skin to cover it with a waterproof film, can be advantageously used for the treatment of scars.

Scars are particularly fragile and sensitive not only to external pathogens, but also to ultraviolet (UV) radiation from the sun.

Several products have already been offered commercially for the protection of scars, in particular with respect to UV radiation. Some of them are in the form of emulsion creams and contain a large amount of water. These water-based products include very high levels of sun filters to guarantee sufficient effectiveness against UV radiation (of the order of 10 to 35% by weight).

A cream making it possible to reduce the scars containing from 2 to 7.5% by weight of Octinoxate and from 0.5 to 7.5% by weight of zinc oxide has been described in the document US 7,241,451. This cream has the drawback, however, of having poor resistance to water, so that the sun protection of the scar disappears as soon as the skin is brought into contact with water. In addition, this type of cream has the disadvantage of not resisting friction.

Furthermore, a certain proportion of the sunscreens that these formulations contain tend to penetrate the skin, so that in order to guarantee effective protection of the skin against UV radiation, the composition must contain a high proportion of organic filter (s) (s).

Liquid dressings formulated in a volatile solvent are generally in the form of a fluid which is applied to the skin via an appropriate applicator, such as a spray, a brush, a spatula or a palette. The volatile solvent evaporates on contact with the skin so as to leave a solid film which protects the skin.

Liquid dressings forming a film on the skin have the advantage of limiting the penetration of the constituents into the skin since the film formed is solid and remains on the surface. In addition, these films being resistant to water and rubbing, it is possible to keep them for several days after their application.

Document FR 2 929 522 has proposed a liquid dressing in the solvent phase containing organic sunscreens and inorganic sunscreens in large quantities. However, the Applicant has been able to observe that the inorganic filters decant over time, so that the composition is not stable during storage.

In addition, contrary to the teaching of this document, the Applicant has highlighted that it is not necessary to incorporate an inorganic sunscreen to obtain effective protection against UV. The Applicant has thus optimized the nature and the quantity of sunscreen to be incorporated into a liquid dressing in solvent phase.

The Applicant has moreover discovered, against all expectations, that the organic ButylMethoxydibenzoylmethane (Avobenzone) filter retains, in this type of formulation, a high sun protection power even after irradiation, so that it is not necessary to add it a photostabilizing agent, such as Octocrylene conventionally used in combination with it.

The present invention thus provides liquid dressings offering satisfactory absorption in UV by using a limited amount of solar filter (s), preferably organic (s).

The present invention therefore relates to a fluid composition intended to be applied to the skin containing a polymer, a plasticizer, a solvent for said polymer, excluding water which is volatile, and at least one organic sunscreen, characterized in that the total content of solar filter (s) is between 0.5 and 2.2% by weight of the total weight of the composition, the volatile solvent represents from 60 to 90% by weight relative to the total weight of the composition, and the polymer represents from 5 to 20% by dry weight of the total weight of the composition.

The polymer is preferably capable of forming a continuous film on the skin, after application of the composition according to the invention. The polymer is preferably insoluble in water and forms a film insoluble in water once the volatile solvent of the composition has evaporated. For example, hydroxypropylcellulose and hydroxyethylcellulose do not form dry films insoluble in water. The polymer is preferably soluble in a volatile solvent other than water. The polymer can be chosen from polymers of natural origin, guar gums, arabic gums, alginates, xanthan gum, gelatin, chitosan, silicates, hydrated silicas, polyurethanes, polyesters, polyester amides, polyamides, polyureas, vinyl polymers, acrylic polymers, polyvinylbutyrals, alkyd resins, resins derived from aldehyde condensation products such as arylsulfonamide formaldehyde resins, arylsulfonamide epoxy resins, ethyltosylamide resins, acetophenone / formaldehyde resins, and mixtures thereof.

The vinyl polymers can result from the homopolymerization or from the copolymerization of monomers chosen from vinyl esters such as vinyl acetate, vinyl neodecanoate, vinyl pivalate, vinyl benzoate and vinyl t-butyl benzoate and styrenic monomers such as styrene and alpha-methyl styrene.

The acrylic polymers can be homopolymers of acrylic acid, copolymers of acrylic acid, homopolymers of methacrylic acid or copolymers of methacrylic acid.

According to one embodiment, the polymer is chosen from cellulosic polymers, in particular hydroxypropylmethylcellulose, cellulose ethers, cellulose esters, nitrocelluloses, cellulose derivatives which are insoluble in water, and mixtures thereof.

According to one embodiment, the polymer is a nitrocellulose, preferably chosen from nitrocelluloses of high viscosity. In particular, nitrocelluloses of quality between RS 1/2 second and RS 20 seconds can be used according to the American standard, corresponding to a quality between 8E and 21E according to the European standard. We prefer for example nitrocellulose grade 10E or 11E (RS 15 seconds according to the American standard).

The nitrocellulose can be chosen in particular from nitrocelluloses RS 5 sec. and RS 15 sec. marketed by HERCULES, DHL products^® 120/170, DHL^® 25/45 or DHX^® 40/70 marketed by Nobel Enterprises, nitrocelulloses E 840^® and E 620^® produced by Wolff Cellulosics, and the products marketed under the references E80^®, E70®, E60^® and E40^® by SNPE- Bergerac. The nitrocellulose can be supplied in dry form or in solution in a solvent such as isopropanol or ethanol. The polymer is preferably present in a content ranging from 5 to 20% by dry weight of the total weight of the composition, for example from 6 to 15% or even from 6 to 9% by dry weight, relative to the total weight of composition.

The plasticizer makes it possible to soften the film; it is advantageously chosen from oils of plant origin and their oxyethylenated derivatives. Vegetable oil can be:

The vegetable oil is advantageously chosen from sesame oil, castor oil, almond oil, canola oil, hazelnut oil, pistachio oil, linseed oil , borage oil, hemp oil, jojoba oil, sunflower oil, wheat germ oil, corn oil and / or corn germ oil, peanut, avocado oil, safflower oil, rapeseed oil, olive oil, argan oil, sunflower oil, grape seed oil, soybean oil, walnut oil, pumpkin seed oil, palm oil, coconut oil, and mixtures thereof.

The oil can also be a derivative of one of the vegetable oils mentioned above. It may be hydrogenated oil or not, peroxidized or not.

You can also choose the plasticizer from:

- esters of monocarboxylic acid such as isononyl isononanoate, oleyl erucate or octyl-2-docecyl neopentanoate;

- fatty alcohols such as octyldodecanol, 2-butyloctanol, 2-hexyl decanol, 2-undecylpentadecanol, oleic alcohol;

- fatty acids such as oleic acid, linoleic acid, linolenic acid;

- glycols and their derivatives, such as diethylene glycol ethyl ether, diethylene glycol methyl ether, polyethylene glycols, polypropylene glycols;

- dicarboxylic acid esters, such as citrates (acetyltributyl citrate), phthalates (dibutylphthalate), adipates, sebacates (dibutylsebacate);

- glyceryl triacetin or triacetate;

- glycerin;

- their mixtures.

The plasticizer is preferably soluble in the solvent of the polymer.

Advantageously, the plasticizer and the polymer are present in the composition according to the invention in a weight ratio ranging from 0.5 to 1.5, and better still ranging from 0.7 to 1.2, more particularly close to 1.

In the context of the present invention, the term "organic sunscreen" means any organic compound absorbing UV radiation in the wavelength range generally ranging from 280 nm to 400 nm. The solar filter S

organic compound used according to the invention can be a compound filtering UV-A radiation of wavelengths between 320 and 400 nm, a compound filtering UV-B radiation of wavelengths between 280 and 320 nm, a compound filtering UV-A and UV-B radiation or one of their mixtures.

The composition preferably comprises less than 0.5%, more preferably less than 0.2% by weight of inorganic sun filter (s) relative to the total weight of the composition.

The composition of the invention is preferably free from inorganic sunscreen.

The total amount of sunscreen (s) in the composition is low, preferably composed between 0.5 and 2.2%, more preferably between 1.2 and 1.8%, preferably of the order 1.5% by weight relative to the total weight of the composition.

The organic filter can be chosen from organic filters active in UV-A, organic filters active in UV-B, organic filters active in UV-A and UV-B, and mixtures thereof.

An organic filter active in UV-A is advantageously chosen from: dibenzoylmethane derivatives, for example ButylMethoxydibenzoylmethane (designation INCI) or Azobenzone (designation USAN) sold in particular under the trade name PARSOL^® 1789, or risopropylDibenzoylmethane,

- menthylanthranilate sold in particular under the reference NEO HELIOPAN^® MA by SYMRISE,

- their mixtures.

The composition of the invention advantageously contains a dibenzoylmethane derivative without adding a photostabilizing agent to it, such as Octocrylene. According to one embodiment, a liposoluble organic filter absorbing in UV-B is added to the dibenzoylmethane derivative.

The content of active organic filter in UV-A, in particular of dibenzoylmethane derivative, is advantageously less than 1% by weight, for example between 0.2 and 0.8% by weight, preferably between 0.3 and 0.7% by weight more preferably of the order of 0.5% by weight relative to the weight of the composition.

The composition may contain a filter active in UV-B, preferably liposoluble, which can be chosen from sun filters absorbing only wavelengths located in UV-B, sun filters absorbing both in 'UV-A and UV-B, and mixtures thereof.

The active filter only in the UV-B can be chosen from:

- salicylic derivatives: Homosalate sold in particular under the name NEO HELIOPAN^® HMS; Ethylhexyl Salicylate sold in particular under the name NEO

HELIOPAN^® OS by SYMRISE; Octyl Salicylate sold in particular under the name NEO HELIOPAN^® type 05;

- cinnamates: EthylhexylMethoxycinnamate sold in particular under the trade name PARSOL^® MCX by DSM NutritionalProducts, Inc .; Isopropyl ethoxycinnamate; IsoamylMethoxycinnamate sold in particular under the trade name NEO HELIOPAN^® E 1000 by SYMRISE; DiisopropylMethylcinnamate; Cinnoxate; Glyceryl Ethylhexanoate-

Dimethoxycinnamate;

- Benzylidene camphor derivatives: 3-Benzylidene camphor manufactured under the name MEXORYL^® SD by CHIMEX; Camphor methylbenzylidene sold in particular under the name NEO HELIOPAN^® MBC;

- triazine derivatives: Ethylhexyltriazone sold in particular under the trade name UVINUL^® T150 by BASF, DiethylhexylButamidoTriazone sold under the trade name UVASORB^® HEB, Bis- EthylhexyloxyphenolMethoxyphenyl-Triazine;

- para-aminobenzoates, such as Ethyl PABA; EthylDihydroxypropyl PABA; EthylhexylDimethyl PABA (ESCALOL^® 507 of ISP);

- imidazoline derivatives: EthylhexylDimethoxybenzylideneDioxoimidazoline- Propionate;

- Benzalmalonate derivatives: polyorganosiloxanes with benzalmalonate function such as Polysilicone-15 sold in particular under the trade name PARSOL^® SLX by DSM Nutritional Products Inc .; Di-neopentyl-4'- methoxybenzalmalonate;

- and their mixtures.

An active filter in both the UV-A and the UV-B can be chosen from:

- Benzophenone derivatives: Benzophenone-1 sold under the trade name UVINUL^® 400; Benzophenone-2 sold under the trade name UVINUL D50; Benzophenone-3 or Oxybenzone sold under the trade name UVINUL^® M40; Benzophenone-4 sold under the trade name UVINUL^® MS40; Benzophenone-6 sold under the trade name HELISORB 11; Benzophenone-8 sold under the trade name SPECTRASORB^® UV-24; - phenylbenzotriazole derivatives: DrométrizoleTrisiloxane sold in particular under the name Silatrizole^® by RHODIA CHIMIE; Methylene bis- BenzotriazolylTetramethylbutylphenol sold in solid form in particular under the trade name MIXXIM^® BB / 100 by FAIRMOUNT CHEMICAL;

- bis-resorcinyltriazines derivatives: Bis-

EthylhexyloxyphenolMethoxyphenylTriazine sold in particular under the trade name ΉΝθεθ ^ Β^® S by CIBA GEIGY;

- benzoxazole derivatives: 2,4-bis- [5-l (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) -imino] -6- (2-ethylhexyl) -imino-1, 3,5- triazine sold in particular under the name of Invasorb^® K2A by Sigma 3V;

- and their mixtures.

According to one embodiment of the invention, the organic sun filter is a mixture of an absorbent sun filter in UV-A and a filter sun filter in UV-B.

One can for example add to an organic filter active in UV-A, a fat-soluble UV-B filter chosen from cinnamates, in particular ethylhexyl-methoxycinnamate (designation INCI) or Octinoxate (designation USAN) sold under the trade name PARSOL^® MCX.

The organic sunscreen can be a mixture of butyl-methoxydibenzoylmethane (USAN Avobenzone) and ethylhexyl-methoxycinnamate (USAN Octinoxate).

The UV-B liposoluble organic filter content, in particular of ethylhexylmethoxycinnamate, in the composition of the invention is advantageously less than 1.2%, for example between 0.5 and 1.2% by weight, preferably between 0 , 8 and 1.2% by weight, more preferably of the order of 1% by weight relative to the weight of the composition.

According to one embodiment, the mass ratio between the dibenzoylmethane derivative and the cinnamate derivative is between 0.3 and 0.7, preferably of the order of 0.5.

The organic sunscreen comprising a dibenzoylmethane derivative and a cinnamate derivative is advantageously present in an amount between 0.5 to 2.2% by weight, preferably between 1.2 and 1.8% by weight, more preferably from about 1.5% by weight relative to the total weight of the composition.

The compositions of the invention also contain a volatile solvent, which preferably dissolves the polymer and the plasticizer. The latter makes it possible to dissolve and homogenize the ingredients and its volatile nature participates in the formation of a solid and continuous film on the skin following the application.

In the context of the present invention, the term “volatile solvent” is intended to mean a solvent capable of evaporating rapidly on contact with the skin. Water is excluded from this definition. Volatile solvents or volatile solvent mixtures with a boiling point above 50 ° C (at atmospheric pressure) are preferred.

As usable solvent, there may be mentioned:

- ketones such as methyl ethyl ketone, methyl isobutyl ketone, diisobutyl ketone, isophorone, cyclohexanone, acetone;

- Alcohols such as ethanol, isopropanol, n-propanol, n-butanol, diacetone alcohol, 2-butoxyethanol, cyclohexanol;

- glycols such as ethylene glycol, propylene glycol, pentylene glycol, glycerol;

- propylene glycol ethers such as propylene glycol monomethyl ether, propylene glycol monomethyl ether acetate, dipropylene glycol mono n-butyl ether;

- esters such as ethyl acetate, methyl acetate, propyl acetate, n-butyl acetate, isopentyl acetate;

- methylal;

- ethers such as diethyl ether, dimethyl ether or dichlorodiethyl ether;

- silicone solvents, in particular hexamethylsiloxane and polydimethylsiloxanes;

- their mixtures.

The volatile solvent will advantageously be chosen from ethanol, ethyl acetate and their mixtures. In particular, a mixture of ethyl acetate and ethanol will be chosen in proportions of between 1/1 and 3/1, preferably 2/1. The amount of volatile solvent preferably represents from 60 to 90% by weight relative to the total weight of the composition, advantageously from 70 to 90% by weight relative to the total weight of the composition.

The composition is essentially devoid of water. It preferably contains less than 2% by weight.

The compositions according to the invention may also contain additives usually used in the preparation of dressings, such as perfumes, preservatives, depigmenting agents, anti-bacterial agents, antifungal agents, healing agents, painkillers, anti-inflammatory, hydrating agents, keratolytic agents, vitamins, glycerin, citric acid.

In general, the assets are chosen from:

- antibacterials such as Polymyxin B, penicillins (Amoxycillin), clavulanic acid, tetracyclines, Minocycline, chlorotetracycline, aminoglycosides, Amikacin, Gentamicin, Neomycin, silver and its salts (Silver sulfadiazine), probiotics;

- antiseptics such as sodium mercurothiolate, eosin, chlorhexidine, phenylmercury borate, hydrogen peroxide, Dakin liquor, triclosan, biguanide, hexamidine, thymol, Lugol, Povidone iodine, Merbromin, Benzalkonium and Benzethonium Chloride, ethanol, isopropanol;

- anti-virals such as Acyclovir, Famciclovir, Ritonavir;

- anti fungals such as polyenes, Nystatin, Amphotericin B, Natamycin, imidazoles (Miconazole, Ketoconazole, Clotrimazole, Éconazole,

Bifonazole, Butoconazole, Fenticonazole, Isoconazole, Oxiconazole, Sertaconazole, Sulconazole, Thiabendazole, Tioconazole), triazoles (Fluconazole, Itraconazole, Ravuconazole, Posaconazole, Voriconazole), allylamines, Butafine, Naftafine, Naftafine

- Flucytosine (antimetabolite), Griseofulvin, Caspofungin, Micafungin;

- painkillers such as Paracetamol, Codeine, Dextropropoxyphene, Tramadol, Morphine and its derivatives, Corticoids and derivatives;

- anti-inflammatory drugs such as Glucocorticoids, non-steroidal anti-inflammatory drugs, Aspirin, Ibuprofen, Ketoprofen, Flurbiprofen,

Diclofenac, Aceclofenac, Ketorolac, Meloxicam, Piroxicam, Tenoxicam, Naproxen, Indomethacin, Naproxcinod, Nimesulide, Celecoxib, Etoricoxib, Parecoxib, Rofecoxib, Valenecox niflumic acid, mefenamic acid;

- active ingredients promoting healing such as Retinol, Vitamin A, Vitamin E, N-acetyl-hydroxyproline, Centella Asiatica extracts, papain, silicones, essential oils of thyme, niaouli, rosemary and sage, hyaluronic acid, synthetic polysulfated oligosaccharides having 1 to 4 ose units such as the potassium salt of octasulfated sucrose, the silver salt of octasulfated sucrose or sucralfate, Allantoin; - depigmenting agents such as kojic acid (Kojic Acid SL^® - Quimasso (Sino Lion)), Arbutin (Olevatin^® - Quimasso (Sino Lion)), the mixture of sodium palmitoylpropyl and white water lily extract (Sepicalm^® - Seppic), undecylenoyl phenylalanine (Sepiwhite^® - Seppic), licorice extract obtained by fermentation with Aspergillus and ethoxydiglycol (Gatuline Whitening^® - Gattefossé), octadecenedioic acid (ODA White^® - Sederma), alpha-arbutin (Alpha-arbutin^®, SACI-CFPA (Pentapharm)), the aqueous extract of Arctophylos Uva Ursi leaves (elfade-J^® - SACI-CFPA (Pentapharm)), the mixture of Gigawhite complex plant^® (SACI-CFPA (Alpaflor)), diacetyl boldine (Lumiskin^® - Sederma), Japanese mandarin extract (Melaslow^® - Sederma), the mixture of lemon extract enriched with citric acid and cucumber extract (Uninontan^®U-34 - Unipex), the mixture of Rumex occidentalis extract and vitamin C (Tyrostat^® 11 - Unipex), oligopeptides (Melanostatin 5^® - Unipex), kojic dipalmitate (KAD-15^® - Quimasso (Sino Lion)), the natural Vegewhite complex^® from LCW, wheat germ extracts (Clariskin^® II - Silab), ethyldiamine triacetate (EDTA);

- keratolytic agents such as salicylic acid, zinc salicylate, ascorbic acid, alpha hydroxyl acids (glycolic, lactic, malic, citric, tartaric acid), extracts of Silver Maple, Griottier, Tamarind , urea, topical keratoline retinoid^® (Sederma), the proteases obtained by fermentation of Bacillus Subtilis, the Linked-Papain product^® (SACI-CFPA), papain (proteolytic enzyme from the papaya fruit);

- restructuring active agents (for example reshaping appendages) such as silica derivatives, vitamin E, chamomile, calcium, horsetail extract, Li pester of silk;

- anesthetics such as benzocaine, lidocaine, dibucaine, pramoxine hydrochloride, bupivacaine, mepivacaine, prilocaine, etidocaine.

As indicated above, the composition according to the present invention is in the form of a fluid liquid intended to be applied using a suitable device. It is advantageously formulated so that it can be used in different possible forms, in particular in the form of a bottle with an appropriate applicator, such as a brush or a palette, a roll-on, or in the form of a spray, of a lip tube. , or foams.

The invention also relates to the composition described above for its use in the protection of scars. According to one embodiment, the compositions according to the present invention are intended to be applied to scars, whether they are linked to an accident, an illness or following surgery.

These compositions can also be used for any skin condition for which UV exposure is undesirable.

Mention may be made, for example, of acne, chickenpox, shingles, rosacea, first degree burns, eczema, hyperpigmentation, lucitis, vitiligo, xerosis, prophecy, stretch marks, psoriasis, insect bites.

The invention also relates to the use of a composition as defined above for the preparation of a dressing intended to protect risk areas such as scars.

The following examples illustrate the invention without limiting its scope.

Example 1:

The following composition was prepared.

<img file="WO2012131237A1_D0001.tif" />

Procedure:

Ingredients 2 to 6 were mixed with stirring at 700 rpm for 10 minutes with a propeller stirrer. The nitrocellulose was then dispersed in the mixture with stirring, and the mixture was stirred successively for 20 minutes at 1100 rpm and for 30 minutes at 2000 rpm.

Filtering power measurement:

The composition according to the invention was spread out homogeneously and calibrated on an inert support, then it was left to dry so that the volatile solvent evaporated. A film 10 microns thick was obtained which was separated from the support.

The Sun Protection Factor (SPF) of the composition was measured in vitro on the composition film previously irradiated so as to approximate the conditions encountered in vivo. The film was previously irradiated for 30 minutes with a dose of standard sunlight between 2 and 4 DEM. The DEM value retained was 25 mJ / cm2 erythemal efficiency, this value corresponding to an exposure of 15 minutes to the sun at its zenith (standard sun) with an erythemal power of 4 DEM / h, the UVB spectroradiometric flux being 0.365 mW / cm2 between 290 and 320 nm, the UVA spectroradiometric flux being 6.0 mW / cm2 between 320 and 400 nm (UVA / UVB ratio: 16.5 / 1).

The method used to measure the SPF followed the principles described by BL Diffey and J. Robson in JSCC, 40, 127-133, May-June 1989.

The equipment used included:

- A "KONTRON 930" spectrophotometer equipped with a UV source and a double monochromator capable of delivering an energy flow between 250 and 800 nm;

- A light source for irradiation: CPS + SUNTEST (ATLAS) with standard filter and Schott WG 320 filter. A PMMA plate containing UV filters is taken as a reference witness.

The average SPF value obtained from 3 to 5 measurements on the 10 µm film was 243 (± 74).

The film of the invention has protective properties against

UVA and UVB, with good spectral distribution between UVA and UVB. The critical wavelength is 370 nm.<img file="WO2012131237A1_D0002.tif" />

Example 2:

The following composition was prepared by following the procedure of Example 1.

The average value of the SPF was calculated according to the method of the example

1. The average value of SPF obtained after pre-irradiation on 5 measurements was 17.10 (± 0.32). The product therefore presented effective sun protection. Comparative example 3:

The following composition was prepared:

<img file="WO2012131237A1_D0003.tif" /> Procedure:

Ingredients 2 to 6 were mixed with stirring at 700 rpm for 10 minutes with a propeller stirrer. The nitrocellulose was then dispersed in the mixture with stirring, and the mixture was stirred successively for 20 minutes at 1100 rpm and for 30 minutes at 2000 rpm.

The nitrocellulose content (percentage by dry weight) of Example 4 was 20%. The composition according to Example 4 was very viscous and runny. Therefore, it was impossible to spread it with a brush. The film obtained was very irregular and not homogeneous.

Comparative example 4:

The following composition was prepared:

<img file="WO2012131237A1_D0004.tif" />

Procedure:

Ingredients 2 to 6 were mixed with stirring at 700 rpm for 10 minutes with a propeller stirrer. The nitrocellulose was then dispersed in the mixture with stirring, and the mixture was stirred successively for 20 minutes at 1100 rpm and for 30 minutes at 2000 rpm. The nitrocellulose content (percentage by dry weight) of Example 5 was 4.8%. The composition according to Example 5 was very liquid and did not make it possible to obtain a film thick enough on the skin to have the required sun protection. The film formed was extremely thin, which made it more sensitive to friction and washing.

Comparative example 5:

The following composition was prepared:

<img file="WO2012131237A1_D0005.tif" />

Procedure:

Ingredients 2 to 6 were mixed with stirring at 700 rpm for 10 minutes with a propeller stirrer. The nitrocellulose was then dispersed in the mixture with stirring, and the mixture was stirred successively for 20 minutes at 1100 rpm and for 30 minutes at 2000 rpm.

Filtering power measurement:

The composition according to Example 6 was spread out homogeneously and calibrated on an inert support, then it was left to dry so that the volatile solvent evaporated. A film 10 microns thick was obtained which was separated from the support. The Sun Protection Factor (SPF) of the composition was measured as in Example 1.

The spectrophotometer showed a saturation above 1.2% by weight of Parsol MCX. Similarly, for Parsol 1789, saturation has been shown to be 1% by weight.