Nova Patents
WO2005076216A3

Method and system for automaticed digital image based flourescent in situ hybridization (fish) analysis

Abstract

A method and system for automated digital fluorescent in situ hybridization (FISH) image analysis. Luminance parameters from a digital image of a biological tissue sample to which a fluorescent compound (e.g., LSI-HER-2/neu and CEP-17 dyes) have been applied are analyzed to determine plural regions of interest. Fluorescent color signals in the plural regions of interest including plural cell nuclei are identified, classified and grouped into plural groups. Each of the plural groups is validated based on pre-defined conditions. A medical diagnosis or prognosis or medical, life science or biotechnology experiment conclusion determined using a count of plural ratios of validated fluorescent color signals within each of the cell nuclei within the plural groups.

Term

No projected expiry on record.

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Every citation, both waysCites: the store holds 2 of 3

Citations
DocumentRelationOfficeCategoryCited duringRelevant claims
WO0120044A2CitesWorld Intellectual Property Organization (WIPO)XInternational search1-29
US5427910ACitesUnited States of AmericaXInternational search1-29
KOZUBEK M ET AL: "High-resolution cytometry of FISH dots in interphase cell nuclei.", CYTOMETRY : THE JOURNAL OF THE SOCIETY FOR ANALYTICAL CYTOLOGY. 1 AUG 1999, vol. 36, no. 4, 1 August 1999 (1999-08-01), pages 279 - 293, XP002341432, ISSN: 0196-4763Non-patent––International search–
LERNER B ET AL: "Automatic signal classification in fluorescence in situ hybridization images.", CYTOMETRY : THE JOURNAL OF THE SOCIETY FOR ANALYTICAL CYTOLOGY. 1 FEB 2001, vol. 43, no. 2, 1 February 2001 (2001-02-01), pages 87 - 93, XP002341433, ISSN: 0196-4763Non-patent––International search–