Antimicrobial, anti-inflammatory, wound-healing and disinfecting glass and use thereof

Antimicrobial, anti-inflammatory, wound healing and disinfectant glass and its use

The invention relates to an antimicrobial, anti-inflammatory, wound-healing and disinfecting glass and a glass powder comprising such a glass.

Glasses which comprise iodine or generally halides for a biological or medical application are known from the following documents:

DE 39 39 831 JP 9114 6436 US 5 807 641

DE 39 39 831 shows a crystallized glass or a glass ceramic and in particular a biocompatible glass or a biocompatible glass ceramic which can be used to repair a damaged or destroyed part of a tooth. For coloring, DE 39 39 831 provides for the use of a colorant, such as, for example, a noble metal halide. The halides are not described in detail.

From US 5 807 641 an antibacterial and anti-fungicidal glass composition for ceramic products, such as for example sanitary materials, has become known, whereby the materials can comprise a silver halide. The glasses described in US Pat. No. 5,807,641 are used in particular as glazes. From JP-A-91146436 a microbicidal glass for the treatment of water or for the destruction of algae and microorganisms in water has become known. The glass according to JP-A-91146436 comprises halides as a raw material.

The object of the invention is to provide an antimicrobial, anti-inflammatory and disinfectant glass which itself has an anti-microbial and anti-inflammatory effect and which synergistically uses its disinfectant effect by adding iodide to the glass.

The object is achieved by iodide-containing glass compositions according to claim 1.

Iodine or^" Iodide has an antimicrobial effect that has long been used in the medical field. An iodine tincture is a clear, brown-red liquid that consists of 2.5 parts of iodine, 2.5 parts of potassium iodide, 28.5 parts of water and 66.5 parts of alcohol (90%).

Due to the low content of iodide in the glass, this invention is excellently suitable for food supplements. Glasses doped higher with iodide show a clear antimicrobial effect as well as disinfectant and anti-inflammatory or wound-healing properties, whereby this effect synergistically exceeds the individual effects of the glass and the iodide ions.

The glass contains Si0₂ as a network builder between 30-80% by weight. At lower concentrations, the hydrolytic resistance decreases significantly, so that grinding in aqueous media can no longer be guaranteed without significant dissolution of the glass. At higher values, the crystallization stability can decrease and the processing temperature increases significantly, so that the melting and hot forming properties deteriorate.

Nβ_GO is used as a flux when melting the glass. The melting behavior is negatively influenced at total concentrations of less than 5%. In addition, the necessary mechanism of ion exchange no longer works sufficiently to achieve an antibacterial effect. At concentrations higher than 40% by weight, there is a deterioration in chemical resistance or hydrolytic resistance, particularly in connection with a decrease in SiO 2₂-Share to watch.

P₂0₅ is a network builder and can increase crystallization stability. The concentrations should not be above 15% by weight, otherwise the chemical resistance of the silicate glass will decrease too much. P, O_s improves the surface reactivity of the glasses.

B₂0₃ is a network builder and increases chemical resistance. The reactivity of the glass and thus the effect can be controlled by varying the contents.

CaO improves the chemical resistance especially in the slightly alkaline range and is therefore necessary to prevent the glass from dissolving in aqueous media. It also contributes to the ion exchange with H +.

MgO improves the chemical resistance especially in the slightly alkaline range and is therefore necessary to prevent the glass from dissolving in aqueous media. It also contributes to the ion exchange with H +. K_JOT and Li₂0 additions favor the interchangeability of sodium and potassium, and lithium itself can be exchanged for H -honing.

The amount of Al₂0₃ can be added to increase the crystallization stability up to a maximum of 10% by weight. -

Fluoride can be added with iodide to achieve synergistic enhancement.

The glass according to the invention can be produced on an industrial scale using standard processes.

In a preferred embodiment, the glass contains 30-60% by weight SiO₂ , 2-40% by weight Na ^ O, 5-40% by weight CaO, 1-15% by weight P₂O_s as well as XJ_y > 100 ppm, where X, Li, Na, K, Rb, Cs, Be, Mg, Ca, Sr, Ba, Ag, Zn and y = 1 or y = 2.

A particularly preferred embodiment contains 30-60% by weight SiO₂, 5-35 wt% Ns ^ O, 2-10 wt% P₂0₅ as well as XJ_y > 100 ppm, where X, ϊ, Na, K, Rb, Cs, Be, Mg, Ca, Sr, Ba, Ag, Zn and y = 1 or y = 2 To achieve a disinfectant effect, the amount is XJ_y > 500 ppm, in particular> 1% by weight, particularly preferably> 2% by weight.

XJ levels are found in nutritional supplements and when used within the human body_y from 10 ppm to 1% by weight, in particular 10 ppm to 500 ppm, particularly preferably contents 10 ppm to 250 ppm.

The glasses according to the invention can also be obtained in powder form and added to products. The glasses are therefore advantageously suitable for grinding in different grinding media, for example water, ie the glass has adequate hydrolytic resistance.

In addition to production using a melting process, alternative production processes using the sol-gel or reaction sinter route are also conceivable.

Particle sizes of <100 μm can be obtained by a grinding process. Particle sizes of <50 μm or 20 μm have proven to be expedient. Particle sizes <10 μm and smaller than 5 μm are particularly suitable. Particle sizes <1 μm have proven to be particularly suitable

The Mahi process can be carried out dry as well as with aqueous and non-aqueous Mahi media.

Mixtures of different glass powders from the composition range with different compositions and grain sizes are possible to combine certain effects.

The glasses within the claimed composition range meet all requirements regarding use in the areas of paper hygiene, cosmetics, paints, varnishes, cleaning, medical products, cosmetic applications, food additives and use in deodorant products such as deodorants and antiperspirants.

The glass can be used in any suitable form, including the powder form mentioned. Mixtures of different glass puivers from the composition range with different compositions are also possible. Mixing with other glass powders is also possible to combine certain effects. The invention will be described below with reference to exemplary embodiments.

Embodiments

A glass was melted from the raw materials and then shaped into ribbons. These robbons were further processed into powder with a particle size d50 = 4 μm by means of dry grinding.

Table 1 shows compositions (synthesis values) [% by weight] and properties of glasses according to the invention.

Table 1: Compositions of glasses:

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The antibacterial effect of the powder according to Europ. Pharmacopoeia (3rd edition) is given for Example 1 in Table 2.

Table 2: Antibacterial effect of embodiment 1; according to European pharmacopoeia (germ contamination test)

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The antimicrobial, anti-inflammatory, wound healing and disinfectant glasses or glass powder can be used as a food additive, in cosmetic products, deoproducts, in medical products, plastics and polymers, paper hygiene, in paints, varnishes and cleaning and cleaning agents.

Example 1 in water (after 24 h)

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