Expandable stent having a dissolvable portion

BACKGROUND OF INVENTION

00011. Field of the Invention

0002The present invention relates to intravascular stents and methods of treating aneurysms, and more particularly, this invention relates to a covered stent which may be modified to treat an aneurysm located adjacent to a bifurcated blood vessel while permitting blood to flow through the bifurcated vessel, and methods of use thereof.

00032. Description of the Prior Art

0004Expandable stents are widely used in the treatment of vascular diseases. Typically, a stent is inserted into a stenosed blood vessel after an angioplasty to prevent the restenosis of the blood vessels. Expandable stents are also used as aneurysm covers. When a stent is placed across an aneurysm, the blood flow into the aneurysm is decreased. Decreased blood flow within an aneurysm promotes the formation of a thrombus within the aneurysm which ultimately aids in protecting the aneurysm from further expansion or rupture.

0005Optimally, a covered stent is positioned across an aneurysm to completely restrict the blood flow into the aneurysm. Such covered stents, typically covered with a material such as PTFE provide suitable aneurysm covers; however, these stents have certain limitations. For example, covered stents impede blood flow into or out of branching blood vessels. Thus, a covered stent may not be suitable for treating an aneurysm at or near a bifurcated blood vessel.

0006Several patents and patent applications disclose covered stents with various modifications which tend to avoid these limitations inherent with typical covered stents. For example, U.S. Pat. No. 6,030,414, entitled “Variable Stent And Method For Treatment Of Arterial Disease,” discloses a covered stent having predetermined and sized lateral openings for the treatment of arterial disease at or around the intersection of multiple arteries; U.S. Pat. No. 6,497,722, entitled “Method And Apparatus For In-Vivo Tailored Stents Indicated For Use In Tortuous Anatomy,” discloses a stent having a side opening to allow unimpeded blood flow to a branching vessel at the point of stenting; and, U.S. Patent Application Publication No. 2003/0074049, entitled “Covered Stents And Systems For Deploying Covered Stents,” discloses a covered stent which may be perforated in order to allow blood flow into a side branch or bifurcated vessel.

0007Also, U.S. patent application Ser. No. 10/696,667, filed on Oct. 29, 2003, assigned to the same assignee as the subject patent application discloses a covered stent for treating an aneurysm which includes a skeletal stent structure with removable slat members to permit blood to flow through a bifurcated blood vessel. Upon deployment, one or more of the slats may be removed to allow blood to flow through portions of the stent structure while others of the slats are left in place to seal the neck of an adjacent aneurysm. This patent application made of record in the subject patent application and is hereby incorporated and made a part of the subject application.

SUMMARY OF THE INVENTION

0008In accordance with one aspect of the present invention there is provided an aneurysm treatment device including an expandable stent which takes the form of a small diameter skeletal tubular member having a thin wall. The wall of the skeletal tubular member defines a plurality of cells which are formed by a plurality of interconnected strut members. Also, a covering extends over a portion of the expandable stent. The covering exhibits the characteristic of, upon being actuated by applying an activating agent to the covering, dissolving to thereby expose a portion of the expandable stent.

0009In accordance with another aspect of the present invention, the expandable stent takes the form of a metallic structural tubular member and the covering is formed from a polymer, such as ethylene vinyl alcohol. The activating agent may take the form of dimethylsulfoxide. If the activating agent is applied to a selective portion of the coating that portion dissolves to expose the underlying porous stent to permit blood to flow through the stent while the balance of the stent remains intact to cover an aneurysm.

0010In accordance with another aspect of the present invention, there is provided a method of treating an aneurysm including the method steps of providing an expandable stent including a skeletal tubular member having a covering disposed onto the skeletal tubular member, inserting the expandable stent into the blood vessel of a patient, advancing the expandable stent until the covering on the stent is aligned with and covers an aneurysm in the blood vessel, expanding the expandable stent so that the covering extends across the neck of an aneurysm, and applying an activating agent to a portion of the covering to cause that portion of the covering to dissolve to expose a portion of the underlying stent in order to permit blood to flow through that portion of the stent while maintaining a seal across the aneurysm.

0011In accordance with another aspect of the present invention there is provided a method for treating an aneurysm including the steps of providing an expandable stent including a skeletal tubular member having a covering disposed onto the skeletal tubular member, inserting said expandable stent into a blood vessel of a patient, advancing the expandable stent until the covering on the stent is aligned with and covers an aneurysm in the blood vessel and also covers a branching blood vessel, expanding the skeletal tubular member so that the covering extends across the neck of the aneurysm and across a branching vessel, inserting a drug delivery catheter into the branching vessel and advancing the distal tip of the drug delivery catheter to have position proximate to a portion of the covering of the stent which extends across the branching vessel, and applying an activating agent through the drug delivery catheter to that portion of the covering to thereby cause that portion of the covering to dissolve and expose a portion of the porous tubular member thereby permitting blood to flow to or from the branching vessel.

0012In accordance with still another aspect of the present invention, there is provided an aneurysm treatment device which includes an expandable tubular member having a thin wall and in which the wall of the tubular member is formed of a material which exhibits the characteristic that when an activating agent is applied to a portion of the wall of the tubular member that portion of the wall dissolves to provide a passageway through the wall. The wall of the expandable tubular member may be formed of ethylene vinyl alcohol and the activating agent may take the form of dimethylsulfoxide.

BRIEF DESCRIPTION OF THE DRAWINGS

0013<figref idref="DRAWINGS">FIG. 1</figref> is an enlarged oblique view of a covered stent device comprised of an expandable skeletal support member and a outer covering which extends over a portion of the support member;

0014<figref idref="DRAWINGS">FIG. 2</figref> is an enlarged elevational view of the covered stent placed adjacent to the neck of an aneurysm and across a main artery at a bifurcation;

0015<figref idref="DRAWINGS">FIG. 3</figref> is an enlarged elevational view of the covered stent illustrating an activating agent being applied to a portion of the covering device at a branching vessel; and,

0016<figref idref="DRAWINGS">FIG. 4</figref> is an enlarged elevational view of the covered stent with a portion of the covering removed to expose the underlying porous skeletal stent.

DESCRIPTION OF THE PREFERRED EMBODIMENT

0017<figref idref="DRAWINGS">FIG. 1</figref> illustrates an expandable covered stent <b>10</b> which may be used to treat an aneurysm, such as an aneurysm within the brain, occurring in a blood vessel at or near a bifurcation in the blood vessel. In the preferred embodiment of the present invention, the covered stent <b>10</b> is comprised of an expandable skeletal stent <b>12</b> and an outer covering <b>14</b> disposed on the outer surface of the skeletal stent <b>12</b>.

0018More particularly, the skeletal stent <b>12</b> includes a plurality of cells which are formed by a plurality of interconnected strut members to thereby define a structure which may be placed into a vessel and after being properly aligned may then be expanded. The skeletal stent <b>12</b> may either take the form of a balloon expandable stent or a self expanding stent. An example of such a self expanding stent is disclosed in U.S. Pat. No. 6,673,106, entitled, “Intravascular Stent Device,” and an example of a stent and stent deployment system is disclosed in U.S. patent application Ser. No. 10/365,288, entitled, “Expandable Stent And Delivery System,” filed on Feb. 12, 2003. This patent and patent application are assigned to the same assignee as the present patent application and are hereby made of record and incorporated by reference into the present patent application.

0019The outer covering <b>14</b> preferably takes the form of a polymer, such as a thin film of ethylene vinyl alcohol which may be bonded to the surface of the skeletal stent <b>12</b>. This covering, as will be described in more detail, serves to cover the neck of the aneurysm. This material exhibits the characteristic of, upon being activated by applying an agent to the covering, dissolving to expose a portion of the underlying expandable stent.

0020<figref idref="DRAWINGS">FIG. 2</figref> illustrates the covered stent <b>10</b> of <figref idref="DRAWINGS">FIG. 1</figref> positioned within a blood vessel such that the outer covering <b>14</b> extends across the neck of an aneurysm <b>16</b>. As with almost all vascular stents, the covered stent is initially compressed and is passed through the vessel and is then expanded with a balloon catheter or is permitted to self expand into the position as shown. Also, since the aneurysm <b>16</b> occurs at a location adjacent to a parent vessel <b>18</b> which serves to feed the branch vessels <b>20</b>, <b>22</b>, with the placement of the stent with the outer covering <b>14</b> covering the neck of the aneurysm <b>16</b>, it will also obstruct the flow of blood from the parent vessel <b>18</b> into the branching vessels <b>20</b>, <b>22</b>. Aneurysms frequently occur at a bifurcated junction vessels, therefore, it should be observed that one of the major advantages of the present invention is that of providing a covered stent which serves to provide a covering for the neck of the aneurysm while at the same time being modified to allow blood to flow from a bifurcated vessel to other vessels. This modification will be explained in more detail with respect to the following drawings.

0021<figref idref="DRAWINGS">FIG. 3</figref>, which is similar to <figref idref="DRAWINGS">FIG. 2</figref>, illustrates the covered stent <b>10</b> which extends from the branch vessel <b>20</b> to the branch vessel <b>22</b> and is positioned so that the outer covering <b>14</b> occludes both the aneurysm <b>16</b> and the parent vessel <b>18</b>. Once the covered stent <b>10</b> is properly placed within the blood vessels, a drug delivery catheter <b>24</b> may be inserted into the vasculature and passed through the parent vessel <b>18</b> so that the distal end <b>24</b><i>a </i>of the drug delivery catheter is positioned in proximity to the outer covering <b>14</b> of the covered stent <b>10</b> at a region <b>24</b><i>a </i>where the outer covering <b>14</b> occluded the parent vessel <b>18</b>. With the outer covering <b>14</b> formed of a thin film of ethylene vinyl alcohol, preferably an activating agent <b>26</b> such as, for example, dimethylsulfoxide, is applied to the outer covering <b>14</b> in the region where the outer covering <b>14</b> occludes the parent vessel <b>18</b>.

0022<figref idref="DRAWINGS">FIG. 4</figref> illustrates the covered stent <b>10</b> after application of the activating agent and, as is apparent, the activating agent, or dimethylsulfoxide, has dissolved the covering formed of ethylene vinyl alcohol in the desired region of the parent vessel <b>18</b> to thereby expose the underlying porous skeletal stent <b>12</b> at location <b>28</b>. The drug delivery catheter <b>24</b> is then removed from the vasculature, with the result that the covered stent <b>10</b> serves to occlude the neck of the aneurysm <b>16</b> while permitting blood to flow through the parent vessel <b>18</b> and into the branch vessels <b>20</b>, <b>22</b>.

0023In summary, the device of the present invention may be used to treat an aneurysm by providing an expandable stent including a skeletal tubular member having a covering disposed onto the skeletal member, inserting the expandable stent into a blood vessel of a patient, advancing the expandable stent until the covered stent is aligned with and covers an aneurysm in the blood vessel, expanding the skeletal tubular member so that the covering extends across the neck of the aneurysm, and applying an activating agent to a portion of the covering to cause that portion of the covering to dissolve and expose a portion of the underlying skeletal tubular member. Once this method has been performed, the remaining portion of the covering serves as a seal for the aneurysm while permitting blood to flow through all of the adjacent vessels.

0024A novel medical device and method to treat an aneurysm at a bifurcation has been disclosed. Although a preferred embodiment of the present invention has been described, it should be understood that various modifications such as for example removal of a portion of the covering by an electrical or electrolytic process, by a heating process or by other processes may be made by one skilled in the art without departing from the scope of the claims which follow.