Catheter apparatuses having expandable mesh structures for renal neuromodulation and associated systems and methods

CROSS-REFERENCE TO RELATED APPLICATION(S)

p-0002This application claims the benefit of U.S. Provisional Application No. 61/405,117, filed Oct. 20, 2010, and incorporated herein by reference in its entirety.

TECHNICAL FIELD

p-0003The present technology relates generally to renal neuromodulation and associated systems and methods. In particular, several embodiments are directed to catheter apparatuses having expandable mesh structures for intravascular renal neuromodulation and associated systems and methods.

BACKGROUND

p-0004The sympathetic nervous system (SNS) is a primarily involuntary bodily control system typically associated with stress responses. Fibers of the SNS innervate tissue in almost every organ system of the human body and can affect characteristics such as pupil diameter, gut motility, and urinary output. Such regulation can have adaptive utility in maintaining homeostasis or in preparing the body for rapid response to environmental factors. Chronic activation of the SNS, however, is a common maladaptive response that can drive the progression of many disease states. Excessive activation of the renal SNS in particular has been identified experimentally and in humans as a likely contributor to the complex pathophysiology of hypertension, states of volume overload (such as heart failure), and progressive renal disease. For example, radiotracer dilution has demonstrated increased renal norepinephrine (NE) spillover rates in patients with essential hypertension.

p-0005Cardio-renal sympathetic nerve hyperactivity can be particularly pronounced in patients with heart failure. For example, an exaggerated NE overflow from the heart and kidneys to plasma is often found in these patients. Heightened SNS activation commonly characterizes both chronic and end stage renal disease. In patients with end stage renal disease, NE plasma levels above the median have been demonstrated to be predictive for both all causes of death and death from cardiovascular disease. This is also true for patients suffering from diabetic or induced contrast nephropathy. Evidence suggests that sensory afferent signals originating from diseased kidneys are major contributors to initiating and sustaining elevated central sympathetic outflow.

p-0006Sympathetic nerves innervating the kidneys terminate in the blood vessels, the juxtaglomerular apparatus, and the renal tubules. Stimulation of the renal sympathetic nerves can cause increased renin release, increased sodium (Na⁺) reabsorption, and a reduction of renal blood flow. These neural regulation components of renal function are considerably stimulated in disease states characterized by heightened sympathetic tone and likely contribute to increased blood pressure in hypertensive patients. The reduction of renal blood flow and glomerular filtration rate as a result of renal sympathetic efferent stimulation is likely a cornerstone of the loss of renal function in cardio-renal syndrome (i.e., renal dysfunction as a progressive complication of chronic heart failure). Pharmacologic strategies to thwart the consequences of renal efferent sympathetic stimulation include centrally acting sympatholytic drugs, beta blockers (intended to reduce renin release), angiotensin converting enzyme inhibitors and receptor blockers (intended to block the action of angiotensin II and aldosterone activation consequent to renin release), and diuretics (intended to counter the renal sympathetic mediated sodium and water retention). These pharmacologic strategies, however, have significant limitations including limited efficacy, compliance issues, side effects, and others. Accordingly, there is a strong public-health need for alternative treatment strategies.

BRIEF DESCRIPTION OF THE DRAWINGS

p-0007Many aspects of the present disclosure can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale. Instead, emphasis is placed on illustrating clearly the principles of the present disclosure.

p-0008<figref idrefs="DRAWINGS">FIG. 1</figref> illustrates an intravascular renal neuromodulation system configured in accordance with an embodiment of the present technology.

p-0009<figref idrefs="DRAWINGS">FIG. 2</figref> illustrates modulating renal nerves with a catheter apparatus having an expandable mesh structure in accordance with an embodiment of the present technology.

p-0010<figref idrefs="DRAWINGS">FIG. 3</figref> is a view of a distal portion of a shaft and a mesh structure in a delivery state (e.g., a low-profile or collapsed configuration) used in conjunction with a guide catheter within a renal artery in accordance with an embodiment of the present technology.

p-0011<figref idrefs="DRAWINGS">FIG. 4</figref> is a view of the distal portion of the shaft and the mesh structure of <figref idrefs="DRAWINGS">FIG. 3</figref> in a deployed state (e.g., expanded configuration) within a renal artery in accordance with an embodiment of the technology.

p-0012<figref idrefs="DRAWINGS">FIG. 5</figref> is a cross-sectional view along line <b>5</b>-<b>5</b> of <figref idrefs="DRAWINGS">FIG. 4</figref> of the mesh structure in the expanded configuration inside a patient in accordance with an embodiment of the technology.

p-0013<figref idrefs="DRAWINGS">FIG. 6</figref> is a side perspective view of an embodiment of a distal portion of a shaft and a mesh structure in a collapsed configuration in accordance with an embodiment of the technology.

p-0014<figref idrefs="DRAWINGS">FIG. 7</figref> is a side perspective view of the mesh structure of <figref idrefs="DRAWINGS">FIG. 6</figref> in an expanded configuration outside a patient in accordance with an embodiment of the technology.

p-0015<figref idrefs="DRAWINGS">FIG. 8</figref> is a view of a treatment device within a renal artery used in conjunction with a guide catheter in accordance with an embodiment of the technology.

p-0016<figref idrefs="DRAWINGS">FIG. 9</figref> is a view of a treatment device within a renal artery with an open-ended basket configuration in accordance with an embodiment of the technology.

p-0017<figref idrefs="DRAWINGS">FIG. 10</figref> is a view of a treatment device within a renal artery used in conjunction with a guide wire in accordance with an embodiment of the technology.

p-0018<figref idrefs="DRAWINGS">FIG. 11</figref> is a view of a treatment device within a renal artery with a close-ended basket configuration in accordance with an embodiment of the technology.

p-0019<figref idrefs="DRAWINGS">FIG. 12A</figref> is a view of a treatment device within a renal artery with an open-ended tubular mesh configuration in accordance with an embodiment of the technology.

p-0020<figref idrefs="DRAWINGS">FIG. 12B</figref> is a view of a treatment device within a renal artery with another open-ended tubular mesh configuration in accordance with an embodiment of the technology.

p-0021<figref idrefs="DRAWINGS">FIG. 13</figref> is a view of a treatment device within a renal artery with multiple energy delivery elements associated with the structure in accordance with an embodiment of the technology.

p-0022<figref idrefs="DRAWINGS">FIG. 14</figref> is a partial side perspective view of a mesh structure with energy delivery leads threaded through the mesh in accordance with an embodiment of the technology.

p-0023<figref idrefs="DRAWINGS">FIG. 15</figref> is a partial side perspective view of a mesh structure with an energy delivery element threaded onto the fibers of the mesh in accordance with an embodiment of the technology.

p-0024<figref idrefs="DRAWINGS">FIG. 16</figref> is a partial side perspective view of a mesh structure with a ribbon electrode energy delivery element wound about the mesh in accordance with an embodiment of the technology.

p-0025<figref idrefs="DRAWINGS">FIG. 17</figref> is a partial side perspective view of a mesh structure with an insulated ribbon electrode having exposed areas for energy delivery in accordance with an embodiment of the technology.

p-0026<figref idrefs="DRAWINGS">FIG. 18</figref> is a side perspective view of a mesh structure in a collapsed configuration with multiple energy delivery elements distributed about the mesh structure in accordance with an embodiment of the technology.

p-0027<figref idrefs="DRAWINGS">FIG. 19</figref> is a view of the mesh structure of <figref idrefs="DRAWINGS">FIG. 18</figref> in an expanded configuration within a renal artery showing axial distances between the energy delivery elements in accordance with an embodiment of the technology.

p-0028<figref idrefs="DRAWINGS">FIG. 20A</figref> is an end view of a mesh structure in an expanded configuration showing the circumferential offset of the energy delivery elements in accordance with an embodiment of the technology.

p-0029<figref idrefs="DRAWINGS">FIG. 20B</figref> is a side view of the mesh structure of <figref idrefs="DRAWINGS">FIG. 20A</figref>.

p-0030<figref idrefs="DRAWINGS">FIG. 20C</figref> is an end view of a mesh structure in an expanded configuration showing the circumferential offset of the energy delivery elements in accordance with an embodiment of the technology.

p-0031<figref idrefs="DRAWINGS">FIG. 20D</figref> is a side view of the mesh structure of <figref idrefs="DRAWINGS">FIG. 20C</figref>.

p-0032<figref idrefs="DRAWINGS">FIG. 21</figref> is a view of a shaped energy delivery element in accordance with an embodiment of the technology.

p-0033<figref idrefs="DRAWINGS">FIG. 22</figref> is a view of an alternative shaped energy delivery element in accordance with an embodiment of the technology.

p-0034<figref idrefs="DRAWINGS">FIG. 23</figref> is a side perspective view of a mesh structure with varying braid pitch in adjacent cylindrical sections in accordance with an embodiment of the technology.

p-0035<figref idrefs="DRAWINGS">FIG. 24</figref> is a side perspective view of a mesh structure with varying braid pitch in an area surrounding an energy delivery element in accordance with an embodiment of the technology.

p-0036<figref idrefs="DRAWINGS">FIG. 25</figref> is a side perspective view of a mesh structure in which the mesh structure is electrically conductive and serves as the energy delivery element in accordance with an embodiment of the technology.

p-0037<figref idrefs="DRAWINGS">FIG. 26</figref> is a side perspective view of a mesh structure of a treatment device in which the mesh structure is electrically conductive and in which uninsulated areas of the mesh structure serve as the energy delivery elements in accordance with an embodiment of the technology.

p-0038<figref idrefs="DRAWINGS">FIG. 27</figref> is a side perspective view of a treatment device including multiple mesh structures that are electrically conductive and that include uninsulated areas of the mesh structure that are electrically isolated between the two mesh structures in accordance with an embodiment of the technology.

p-0039<figref idrefs="DRAWINGS">FIG. 28</figref> is a view of a mesh structure having a varying circumferential shape in accordance with an embodiment of the technology.

p-0040<figref idrefs="DRAWINGS">FIG. 29</figref> is a view of a mesh structure having a varying circumferential shape in accordance with an embodiment of the technology.

p-0041<figref idrefs="DRAWINGS">FIG. 30</figref> is a side perspective view of a mesh structure of a treatment device in which portions of electrically conductive mesh are separated by portions of electrically nonconductive mesh in accordance with an embodiment of the technology.

p-0042<figref idrefs="DRAWINGS">FIG. 31</figref> is a side perspective view of an alternative mesh structure of a treatment device in which portions of electrically conductive mesh are separated by portions of electrically nonconductive mesh in accordance with an embodiment of the technology.

p-0043<figref idrefs="DRAWINGS">FIG. 32</figref> is a side perspective view of an alternative mesh structure of a treatment device in which portions of electrically conductive mesh are separated by portions of electrically nonconductive mesh in accordance with an embodiment of the technology.

p-0044<figref idrefs="DRAWINGS">FIG. 33</figref> is an illustration of blood flow in a renal artery in accordance with an embodiment of the technology.

p-0045<figref idrefs="DRAWINGS">FIG. 34</figref> is a view of an embodiment of a treatment device in a renal artery, the treatment device including a fluid redirecting element within a mesh structure in accordance with an embodiment of the technology.

p-0046<figref idrefs="DRAWINGS">FIG. 35</figref> is a side perspective view of a mesh structure with a fluid redirecting element in which the mesh structure is in an expanded configuration in accordance with an embodiment of the technology.

p-0047<figref idrefs="DRAWINGS">FIG. 36</figref> is a side perspective view of a mesh structure with a fluid redirecting element in which the mesh structure is in a collapsed configuration in accordance with an embodiment of the technology.

p-0048<figref idrefs="DRAWINGS">FIG. 37</figref> is a partially cutaway side view of a grooved fluid redirecting element within a mesh structure in accordance with an embodiment of the technology.

p-0049<figref idrefs="DRAWINGS">FIG. 38</figref> is a partially cutaway side view of a porous fluid redirecting element within a mesh structure in accordance with an embodiment of the technology.

p-0050<figref idrefs="DRAWINGS">FIG. 39</figref> is a partially cutaway side view of a mesh fluid redirecting element within a mesh structure in accordance with an embodiment of the technology.

p-0051<figref idrefs="DRAWINGS">FIG. 40</figref> is a view of a fluid redirecting element in conjunction with a parachute-type mesh structure in accordance with an embodiment of the technology.

p-0052<figref idrefs="DRAWINGS">FIG. 41</figref> is a graph depicting an energy delivery algorithm that may be used in conjunction with the system of <figref idrefs="DRAWINGS">FIG. 1</figref> in accordance with an embodiment of the technology.

p-0053<figref idrefs="DRAWINGS">FIG. 42</figref> is a kit for packaging components of the system of <figref idrefs="DRAWINGS">FIG. 1</figref> in accordance with an embodiment of the technology.

p-0054<figref idrefs="DRAWINGS">FIG. 43</figref> is a conceptual illustration of the sympathetic nervous system (SNS) and how the brain communicates with the body via the SNS.

p-0055<figref idrefs="DRAWINGS">FIG. 44</figref> is an enlarged anatomic view of nerves innervating a left kidney to form the renal plexus surrounding the left renal artery.

p-0056<figref idrefs="DRAWINGS">FIGS. 45A and 45B</figref> provide anatomic and conceptual views of a human body, respectively, depicting neural efferent and afferent communication between the brain and kidneys.

p-0057<figref idrefs="DRAWINGS">FIGS. 46A and 46B</figref> are, respectively, anatomic views of the arterial and venous vasculatures of a human.

DETAILED DESCRIPTION

p-0058The present technology is directed to apparatuses, systems, and methods for achieving electrically- and/or thermally-induced renal neuromodulation (i.e., rendering neural fibers that innervate the kidney inert or inactive or otherwise completely or partially reduced in function) by percutaneous transluminal intravascular access. In particular, embodiments of the present technology relate to apparatuses, systems, and methods that incorporate a catheter treatment device having an expandable mesh structure or other open structure. The expandable mesh structure can include and/or is associated with at least one element configured to deliver energy (e.g., electrical energy, radiofrequency electrical energy, pulsed electrical energy, thermal energy) to a renal artery after being advanced via a catheter along a percutaneous transluminal path (e.g., a femoral artery puncture, an iliac artery and the aorta, a transradial approach, or another suitable intravascular path). The expandable mesh structure is sized and shaped so that the energy delivery element contacts an interior wall of the renal artery when the mesh structure is in an expanded configuration within the renal artery. In addition, the mesh portion of the expandable mesh structure allows blood to flow through the mesh, thereby maintaining blood flow to the kidney. Further, blood flow in and around the mesh structure may cool the associated energy delivery element and/or surrounding tissue. In some embodiments, cooling the energy delivery element allows for the delivery of higher power levels at lower temperatures than may be reached without cooling. This feature is expected to help create deeper and/or larger lesions during therapy, reduce intimal surface temperature, and/or allow longer activation times with reduced risk of overheating during treatment.

p-0059Specific details of several embodiments of the technology are described below with reference to <figref idrefs="DRAWINGS">FIGS. 1-46B</figref>. Although many of the embodiments are described below with respect to devices, systems, and methods for intravascular modulation of renal nerves using mesh catheter apparatuses, other applications and other embodiments in addition to those described herein are within the scope of the technology. Additionally, several other embodiments of the technology can have different configurations, components, or procedures than those described herein. A person of ordinary skill in the art, therefore, will accordingly understand that the technology can have other embodiments with additional elements, or the technology can have other embodiments without several of the features shown and described below with reference to <figref idrefs="DRAWINGS">FIGS. 1-46B</figref>.

p-0060As used herein, the terms “distal” and “proximal” define a position or direction with respect to the treating clinician or clinician's control device (e.g., a handle assembly). “Distal” or “distally” are a position distant from or in a direction away from the clinician or clinician's control device. “Proximal” and “proximally” are a position near or in a direction toward the clinician or clinician's control device.

I. RENAL NEUROMODULATION

p-0061Renal neuromodulation is the partial or complete incapacitation or other effective disruption of nerves innervating the kidneys. In particular, renal neuromodulation comprises inhibiting, reducing, and/or blocking neural communication along neural fibers (i.e., efferent and/or afferent nerve fibers) innervating the kidneys. Such incapacitation can be long-term (e.g., permanent or for periods of months, years, or decades) or short-term (e.g., for periods of minutes, hours, days, or weeks). Renal neuromodulation is expected to efficaciously treat several clinical conditions characterized by increased overall sympathetic activity, and in particular conditions associated with central sympathetic over stimulation such as hypertension, heart failure, acute myocardial infarction, metabolic syndrome, insulin resistance, diabetes, left ventricular hypertrophy, chronic and end stage renal disease, inappropriate fluid retention in heart failure, cardio-renal syndrome, and sudden death. The reduction of afferent neural signals contributes to the systemic reduction of sympathetic tone/drive, and renal neuromodulation is expected to be useful in treating several conditions associated with systemic sympathetic over activity or hyperactivity. Renal neuromodulation can potentially benefit a variety of organs and bodily structures innervated by sympathetic nerves. For example, a reduction in central sympathetic drive may reduce insulin resistance that afflicts patients with metabolic syndrome and Type II diabetics. Additionally, osteoporosis can be sympathetically activated and might benefit from the downregulation of sympathetic drive that accompanies renal neuromodulation. A more detailed description of pertinent patient anatomy and physiology is provided in Section VI below.

p-0062Various techniques can be used to partially or completely incapacitate neural pathways, such as those innervating the kidney. The purposeful application of energy (e.g., electrical energy, thermal energy) to tissue by energy delivery element(s) can induce one or more desired thermal heating effects on localized regions of the renal artery and adjacent regions of the renal plexus RP, which lay intimately within or adjacent to the adventitia of the renal artery. The purposeful application of the thermal heating effects can achieve neuromodulation along all or a portion of the renal plexus RP.

p-0063The thermal heating effects can include both thermal ablation and non-ablative thermal alteration or damage (e.g., via sustained heating and/or resistive heating). Desired thermal heating effects may include raising the temperature of target neural fibers above a desired threshold to achieve non-ablative thermal alteration, or above a higher temperature to achieve ablative thermal alteration. For example, the target temperature can be above body temperature (e.g., approximately 37° C.) but less than about 45° C. for non-ablative thermal alteration, or the target temperature can be about 45° C. or higher for the ablative thermal alteration.

p-0064More specifically, exposure to thermal energy (heat) in excess of a body temperature of about 37° C., but below a temperature of about 45° C., may induce thermal alteration via moderate heating of the target neural fibers or of vascular structures that perfuse the target fibers. In cases where vascular structures are affected, the target neural fibers are denied perfusion resulting in necrosis of the neural tissue. For example, this may induce non-ablative thermal alteration in the fibers or structures. Exposure to heat above a temperature of about 45° C., or above about 60° C., may induce thermal alteration via substantial heating of the fibers or structures. For example, such higher temperatures may thermally ablate the target neural fibers or the vascular structures. In some patients, it may be desirable to achieve temperatures that thermally ablate the target neural fibers or the vascular structures, but that are less than about 90° C., or less than about 85° C., or less than about 80° C., and/or less than about 75° C. Regardless of the type of heat exposure utilized to induce the thermal neuromodulation, a reduction in renal sympathetic nerve activity (“RSNA”) is expected.

II. SELECTED EMBODIMENTS OF RENAL NEUROMODULATION DEVICES HAVING MESH STRUCTURES

p-0065<figref idrefs="DRAWINGS">FIG. 1</figref> illustrates a renal neuromodulation system <b>10</b> (“system <b>10</b>”) configured in accordance with an embodiment of the present technology. The system <b>10</b> includes an intravascular treatment device <b>12</b> operably coupled to an energy source or energy generator <b>26</b>. In the embodiment shown in <figref idrefs="DRAWINGS">FIG. 1</figref>, the treatment device <b>12</b> (e.g., a catheter) includes an elongated shaft <b>16</b> having a proximal portion <b>18</b>, a handle assembly <b>34</b> at a proximal region of the proximal portion <b>18</b>, and a distal portion <b>20</b> extending distally relative to the proximal portion <b>18</b>. The treatment device <b>12</b> further includes an expandable mesh structure <b>22</b> including an energy delivery element <b>24</b> disposed at or near the distal portion <b>20</b> of the shaft <b>16</b>. As explained in further detail below, the mesh structure <b>22</b> is configured to be delivered to a renal blood vessel (e.g., renal artery) in a low-profile or delivery configuration. Upon delivery to the target treatment site within the renal blood vessel, the mesh structure <b>22</b> is further configured to be deployed into an expanded or treatment configuration, bringing the energy delivery element <b>24</b> in contact with the walls of the vessel. The energy delivery element <b>24</b> is configured to deliver energy at the treatment site and provide therapeutically-effective electrically- and/or thermally-induced renal neuromodulation. In some embodiments, the mesh structure <b>22</b> may be placed in the deployed configuration or arrangement via remote actuation, e.g., via an actuator <b>36</b>, such as a knob, pin, or lever carried by the handle <b>34</b>. In other embodiments, however, the mesh structure <b>22</b> may be movable between the delivery and deployed configurations using other suitable mechanisms or techniques (e.g., self-expanding).

p-0066As will be described in greater detail below, the energy delivery element <b>24</b> is associated with the mesh structure <b>22</b>. That is, the energy delivery element <b>24</b> may be proximate to, adjacent to, adhered to, woven into, or otherwise coupled to the mesh structure <b>22</b>. The associated energy delivery element <b>24</b> may also be formed by selected portions of, or the entirety of, the mesh structure <b>22</b> itself. For example, the fibers of the mesh may be capable of delivering energy. It should also be understood that mesh structure <b>22</b> may include a plurality of energy delivery elements <b>24</b>. When multiple energy delivery elements <b>24</b> are provided, the energy delivery elements <b>24</b> may deliver power independently (i.e., may be used in a monopolar fashion), either simultaneously, selectively, or sequentially, and/or may deliver power between any desired combination of the elements (i.e., may be used in a bipolar fashion). Furthermore, the clinician optionally may be permitted to choose which energy delivery element(s) <b>24</b> are used for power delivery in order to form highly customized lesion(s) within the renal artery, as desired. The energy delivery element <b>24</b> is mounted or integrated into the mesh structure <b>22</b>. As the mesh structure is expanded, the energy delivery element is placed in contact with the wall of a renal artery. The mesh structure <b>22</b> ensures the contact force of the energy delivery element does not exceed a maximum force, thus advantageously providing a more consistent contact force that may allow for more consistent lesion formation.

p-0067The energy source or energy generator <b>26</b> (e.g., a RF energy generator) is configured to generate a selected form and magnitude of energy for delivery to the target treatment site via the energy delivery element <b>24</b>. The energy generator <b>26</b> can be electrically coupled to the treatment device <b>12</b> via a cable <b>28</b>. At least one supply wire (not shown) passes along the elongated shaft <b>16</b> or through a lumen in the elongated shaft <b>16</b> to the energy delivery element <b>24</b> and transmits the treatment energy to the energy delivery element <b>24</b>. A control mechanism, such as foot pedal <b>32</b>, may be connected (e.g., pneumatically connected or electrically connected) to the energy generator <b>26</b> to allow the operator to initiate, terminate and, optionally, adjust various operational characteristics of the energy generator, including, but not limited to, power delivery. The energy generator <b>26</b> can be configured to deliver the treatment energy via an automated control algorithm <b>30</b> and/or under the control of the clinician. In addition, the energy generator <b>26</b> may include one or more evaluation or feedback algorithms <b>31</b> to provide feedback to the clinician before, during, and/or after therapy. Further details regarding suitable control algorithms and evaluation/feedback algorithms are described below with reference to <figref idrefs="DRAWINGS">FIGS. 41-48B</figref>.

p-0068In some embodiments, the system <b>10</b> may be configured to provide delivery of a monopolar electric field via the energy delivery elements <b>24</b>. In such embodiments, a neutral or dispersive electrode <b>38</b> may be electrically connected to the energy generator <b>26</b> and attached to the exterior of the patient, as shown in <figref idrefs="DRAWINGS">FIG. 2</figref>. Additionally, one or more sensors (not shown), such as one or more temperature (e.g., thermocouple, thermistor, etc.), impedance, pressure, optical, flow, chemical or other sensors, may be located proximate to or within the energy delivery element <b>24</b> and connected to one or more supply wires (not shown). For example, a total of two supply wires may be included, in which both wires could transmit the signal from the sensor and one wire could serve dual purpose and also convey the energy to the energy delivery element <b>24</b>. Alternatively, both wires could transmit energy to the energy delivery element <b>24</b>.

p-0069The generator <b>26</b> may be part of a device or monitor that may include processing circuitry, such as a microprocessor, and a display. The processing circuitry may be configured to execute stored instructions relating to the control algorithm <b>30</b>. The monitor may be configured to communicate with the treatment device <b>12</b> (e.g., via cable <b>28</b>) to control power to the energy delivery element <b>24</b> and/or to obtain signals from the energy delivery element <b>24</b> or any associated sensors. The monitor may be configured to provide indications of power levels or sensor data, such as audio, visual or other indications, or may be configured to communicate the information to another device.

p-0070<figref idrefs="DRAWINGS">FIG. 2</figref> illustrates modulating renal nerves with an embodiment of the system <b>10</b>, with further detail regarding the relevant anatomy provided below with reference to <figref idrefs="DRAWINGS">FIG. 44</figref>. The treatment device <b>12</b> provides access to the renal plexus RP through an intravascular path (P), such as from a percutaneous access site in the femoral (illustrated), brachial, radial, or auxiliary artery to a targeted treatment site within a respective renal artery RA. As illustrated, a section of the proximal portion <b>18</b> of the shaft <b>16</b> is exposed externally of the patient. By manipulating the proximal portion <b>18</b> of the shaft <b>16</b> from outside the intravascular path P (e.g., via the handle assembly <b>34</b>), the clinician may advance the shaft <b>16</b> through the sometimes tortuous intravascular path P and remotely manipulate or actuate the distal portion <b>20</b> of the shaft <b>16</b>. Image guidance, e.g., computed tomography (CT), fluoroscopy, intravascular ultrasound (IVUS), optical coherence tomography (OCT), or another suitable guidance modality, or combinations thereof, may be used to aid the clinician's manipulation. Further, in some embodiments image guidance components (e.g., IVUS, OCT) may be incorporated into the treatment device <b>12</b> itself. After the mesh structure <b>22</b> is adequately positioned in the renal artery RA, it can be expanded or otherwise deployed using the handle <b>34</b> or other suitable means until the energy delivery element <b>24</b> is in stable contact with the inner wall of the renal artery RA. The purposeful application of energy from the energy delivery element <b>24</b> is then applied to tissue to induce one or more desired neuromodulating effects on localized regions of the renal artery and adjacent regions of the renal plexus RP, which lay intimately within, adjacent to, or in close proximity to the adventitia of the renal artery RA. The purposeful application of the incapacitating energy may achieve neuromodulation along all or at least a portion of the renal plexus RP.

p-0071The neuromodulating effects are generally a function of, at least in part, power, time, contact between the energy delivery element <b>24</b> carried by the mesh structure <b>22</b> and the vessel wall, and blood flow through the vessel. The neuromodulating effects may include denervation, thermal ablation, and non-ablative thermal alteration or damage (e.g., via sustained heating and/or resistive heating. Desired thermal heating effects may include raising the temperature of target neural fibers above a desired threshold to achieve non-ablative thermal alteration, or above a higher temperature to achieve ablative thermal alteration. For example, the target temperature may be above body temperature (e.g., approximately 37° C.) but less than about 45° C. for non-ablative thermal alteration, or the target temperature may be about 45° C. or higher for the ablative thermal alteration. Desired non-thermal neuromodulation effects may also further include altering the electrical signals transmitted in a nerve.

p-0072<figref idrefs="DRAWINGS">FIG. 3</figref> is a cross-sectional view illustrating one embodiment of the distal portion <b>20</b> of the shaft <b>16</b> and the mesh structure <b>22</b> in a delivery state (e.g., low-profile or collapsed configuration) within a renal artery RA, and <figref idrefs="DRAWINGS">FIG. 4</figref> is a cross-sectional view of the mesh structure <b>22</b> in a deployed state (e.g., expanded configuration) within the renal artery RA. Referring first to <figref idrefs="DRAWINGS">FIG. 3</figref>, the collapsed or delivery configuration of the mesh structure <b>22</b> facilitates insertion and/or removal of the treatment device <b>12</b> and, in certain embodiments, repositioning of the mesh structure <b>22</b> within the renal artery RA. In the collapsed configuration, the mesh structure <b>22</b> is sized and shaped to fit within the renal artery RA and has a diameter that is less than a renal artery lumen diameter <b>52</b> and a length (from a proximal end <b>42</b> of the mesh structure <b>22</b> to a distal end <b>44</b> of the mesh structure <b>22</b>) that is less than a renal artery length <b>54</b>.

p-0073As shown in <figref idrefs="DRAWINGS">FIG. 3</figref>, the distal portion <b>20</b> of the shaft <b>16</b> may flex in a substantial fashion to gain entrance into a respective left/right renal artery by following a path defined by a guide catheter, a guide wire, or a sheath. For example, the flexing of the distal portion <b>20</b> may be imparted by a guide catheter <b>90</b>, such as a renal guide catheter with a preformed bend near the distal end that directs the shaft <b>16</b> along a desired path from the percutaneous insertion site to the renal artery RA. In another embodiment, the treatment device <b>12</b> may be directed to the treatment site within the renal artery RA by engaging and tracking a guide wire (not shown) that is inserted into the renal artery RA and extends to the percutaneous access site. In operation, the guide wire is preferably first delivered into the renal artery RA and the elongated shaft <b>16</b> comprising a guide wire lumen is then passed over the guide wire into the renal artery RA. In some guide wire procedures, a tubular delivery sheath <b>91</b> (described in greater detail below with reference to <figref idrefs="DRAWINGS">FIG. 8</figref>) is passed over the guide wire (i.e., the lumen defined by the delivery sheath slides over the guide wire) into the renal artery RA. Once the delivery sheath <b>91</b> (<figref idrefs="DRAWINGS">FIG. 8</figref>) is placed in the renal artery, the guide wire may be removed and exchanged for a treatment catheter (e.g., treatment device <b>12</b>) that may be delivered through the delivery sheath <b>91</b> (<figref idrefs="DRAWINGS">FIG. 8</figref>) into the renal artery RA. Furthermore, in particular embodiments, the flexing may be controlled from the handle assembly <b>34</b> (<figref idrefs="DRAWINGS">FIGS. 1 and 2</figref>), for example, by the actuatable element <b>36</b> or by another control element. In particular, the flexing of the elongated shaft <b>16</b> may be accomplished as provided in U.S. patent application Ser. No. 12/545,648, “Apparatus, Systems, and Methods for Achieving Intravascular, Thermally-Induced Renal Neuromodulation” to Wu et al., which is incorporated herein by reference in its entirety. Alternatively, or in addition, the treatment device <b>12</b> and its distal portion <b>20</b> may be flexed by being inserted through a steerable guide catheter (not shown) that includes a preformed or steerable bend near its distal end that can be adjusted or re-shaped by manipulation from the proximal end of the guide catheter.

p-0074After locating the mesh structure <b>22</b> in the renal artery RA, further manipulation of the distal portion <b>20</b> and the energy delivery element(s) <b>24</b> within the respective renal artery RA establishes apposition and alignment between the energy delivery element <b>24</b> and tissue along an interior wall of the respective renal artery RA. For example, as shown in <figref idrefs="DRAWINGS">FIG. 4</figref>, the mesh structure <b>22</b> is expanded within the renal artery RA such that the energy delivery element <b>24</b> is in contact with a renal artery wall <b>55</b>. In some embodiments, manipulation of the distal portion <b>20</b> will also facilitate contact between the energy delivery element <b>24</b> and the wall <b>55</b> of the renal artery. The alignment may also include alignment of geometrical aspects of the energy delivery element <b>24</b> with the renal artery wall <b>55</b>. For example, for embodiments in which the energy delivery element <b>24</b> has a cylindrical shape with rounded ends, alignment may include alignment of the longitudinal surface in contact with the artery wall <b>55</b>. In another example, an embodiment may comprise an energy delivery element <b>24</b> with a structured shape or inactive surface, and alignment may include aligning the energy delivery element <b>24</b> such that the structured shape or inactive surface is not in contact with the artery wall <b>55</b>.

p-0075<figref idrefs="DRAWINGS">FIG. 5</figref> is a transverse cross-sectional view along line <b>5</b>-<b>5</b> of <figref idrefs="DRAWINGS">FIG. 4</figref> of the mesh structure <b>22</b> in the deployed or expanded configuration and in contact with the renal artery wall <b>55</b>. One feature of the mesh structure <b>22</b> is that contact with the renal artery wall <b>55</b> is discontinuous. In particular, the mesh structure <b>22</b> includes fibers <b>58</b> or other solid structural elements separated by interstitial spaces <b>57</b>. The mesh structure <b>22</b> expands and creates an interior space <b>60</b> that is accessible to blood flow via the series of interstitial spaces <b>57</b> in the mesh structure <b>22</b>. Another feature of the mesh structure <b>22</b> is that, in particular embodiments, once inserted in a patient, expansion of the mesh structure is limited to the diameter <b>52</b> of the renal artery lumen. That is, the mesh structure <b>22</b> may, in certain embodiments, be more conformable than the renal artery such that the mesh structure <b>22</b> expands to span the lumen diameter <b>52</b> but does not apply sufficient radial force to the renal artery wall <b>55</b> to over-distend or injure the renal artery. Accordingly, an expanded diameter of the mesh structure <b>22</b> may, in some embodiments, be approximately equal to the lumen diameter <b>52</b> of the renal artery. Alternatively, as a renal artery lumen diameter <b>52</b> may vary from patient to patient, the mesh structure <b>22</b> may be configured to be deployed to a range of vessel lumen diameters. For example, a mesh structure <b>22</b> may be configured to expand, unconstrained, in diameter from a collapsed state to a fully deployed state with a diameter of about 10 mm and may be deployed within a renal artery until the mesh structure <b>22</b> and/or the energy delivery element <b>24</b> is/are in contact with the artery wall <b>55</b>.

p-0076The mesh structure <b>22</b> may also be characterized by its diameter in the collapsed or delivery configuration, e.g., a smallest diameter. <figref idrefs="DRAWINGS">FIG. 6</figref>, for example, is a side view of the distal end region <b>20</b> of the treatment device <b>12</b> in the collapsed configuration. A collapsed diameter <b>62</b> of the mesh structure <b>22</b> may be approximately equal to a diameter <b>61</b> of the elongated shaft <b>16</b>. As noted above, for example, the sizing and dimension of the treatment device <b>12</b> may be configured to allow insertion with or without a guide catheter into a patient via an opening in the femoral, brachial, or radial arteries.

p-0077For practical purposes, the maximum outer dimension (e.g., diameter) of any section of the elongated shaft <b>16</b>, including the energy delivery element <b>24</b> it carries, is dictated by the inner diameter of the guide catheter through which the elongated shaft <b>16</b> is passed. In one particular embodiment, for example, an 8 French guide catheter (having, for example, an inner diameter of approximately 0.091 inch, 2.31 mm) may be, from a clinical perspective, the largest guide catheter used to access the renal artery. Allowing for a reasonable clearance tolerance between the energy delivery element <b>24</b> and the guide catheter, the maximum outer dimension of the elongated shaft <b>16</b> may be expressed as being less than or equal to approximately 0.085 inch (2.16 mm). In such an embodiment, the mesh structure <b>22</b> (in a collapsed configuration and including the energy delivery element <b>24</b>) may have a collapsed diameter <b>62</b> that is less than or equal to approximately 0.085 inch (2.16 mm). However, use of a smaller 5 French guide catheter may require smaller outer diameters along the elongated shaft <b>16</b>. For example, a mesh structure <b>22</b> that is to be routed within a 5 French guide catheter would have an outer dimension of no greater than 0.053 inch (1.35 mm). In another example, the mesh structure <b>22</b> and energy delivery element <b>24</b> that are to be routed within a 6 French guide catheter would have an outer dimension of no greater than 0.070 inch (1.78 mm). In still further examples, other suitable guide catheters may be used, and outer dimension and/or arrangement of the shaft <b>16</b> can vary accordingly.

p-0078The mesh structure <b>22</b> may also be characterized by its length <b>64</b> in the collapsed configuration. In particular embodiments, it is envisioned that the length <b>64</b> may be measured from the proximal end <b>42</b> of the mesh structure <b>22</b> (e.g., at an interface of the proximal end <b>42</b> and any coupling <b>72</b> to the elongated shaft <b>16</b>) to the distal end <b>44</b> of the mesh structure <b>22</b>. Further, the length <b>64</b> in the collapsed configuration may generally be suitable for insertion into the renal artery. That is, the length may be approximately equal to or less than a renal artery length or a main renal artery (i.e. a section of a renal artery proximal to a bifurcation). As this dimension may vary from patient to patient, it is envisioned that in some embodiments the mesh structure <b>22</b> may be fabricated in different sizes (e.g., with different lengths <b>64</b> and/or diameters <b>62</b>) that may be appropriate for different patients.

p-0079In one embodiment, the distal end <b>44</b> of the mesh structure <b>22</b> may be coupled to an end piece <b>74</b> (e.g., a collar, shaft, or cap) having a rounded distal portion <b>50</b> to facilitate atraumatic insertion of the treatment device <b>12</b> into a renal artery. In addition, the elongated shaft <b>16</b>, the coupling <b>72</b>, the mesh structure <b>22</b>, and the end piece <b>74</b> may include passages sized and shaped to accommodate a control wire <b>68</b> that is fixed to the distal end <b>44</b> of the mesh structure or the end piece <b>74</b> and passes through the elongated shaft <b>16</b> to the proximal portion <b>18</b> of the elongated shaft <b>16</b>. The control wire <b>68</b> facilitates the expansion and/or contraction of the mesh structure <b>22</b> when it is pulled or pushed to shorten or lengthen the mesh structure <b>22</b>. For example, pulling (i.e., an increase in tension) the control wire <b>68</b> proximally relative to the shaft <b>16</b> may trigger expansion of the mesh structure <b>22</b> by drawing end piece <b>74</b> closer to coupling <b>72</b>. Conversely, pushing (i.e., an increase in compression) the control wire <b>68</b> distally relative to shaft <b>16</b> may lengthen the mesh structure <b>22</b> to a compressed configuration by axially spreading apart end piece <b>74</b> and coupling <b>72</b>. It will be understood that either the shaft <b>16</b> or the control wire <b>68</b> may be held in fixed position with respect to the patient while the other element is translated to create the relative movements described above. In some embodiments the mesh structure <b>22</b> has elastic or super-elastic shape memory properties such that when force is removed the mesh structure elastically returns to a relaxed state. Force may be applied by the control wire <b>68</b> to deform the mesh structure <b>22</b> into one state and when force is removed the mesh structure <b>22</b> returns to its relaxed state. For example, a relaxed state of the mesh structure <b>22</b> may be an expanded configuration as shown in <figref idrefs="DRAWINGS">FIG. 7</figref> and the control wire <b>68</b> may be pushed to lengthen the mesh structure <b>22</b> and reduce its diameter placing it in a collapsed configuration as shown in <figref idrefs="DRAWINGS">FIG. 6</figref>. Alternatively, a relaxed state of the mesh structure may be a collapsed or compressed configuration and the control wire <b>68</b> may be pulled (tension applied) to shorten the mesh structure <b>22</b> and increase its diameter placing it in an expanded configuration.

p-0080In some embodiments the control wire <b>68</b> may be a solid or stranded wire or cable made from a metal or polymer. In other embodiments (such as the example shown in <figref idrefs="DRAWINGS">FIGS. 6 and 7</figref>) the control wire may be a hollow tube that can be passed over a guide wire <b>66</b> to facilitate insertion through an intravascular path to a renal artery.

p-0081The proximal end <b>42</b> of the mesh structure <b>22</b> may be coupled to the elongated shaft <b>16</b> via a coupling piece <b>72</b>. Coupling piece <b>72</b>, for example, may be an integral end of the elongated shaft <b>16</b> (e.g., may not be a separate piece) or may be a separate piece that is associated with the distal region <b>20</b> of the elongated shaft <b>16</b>. The coupling piece <b>72</b> may be formed from the same type of material as the elongated shaft <b>16</b>, or may be formed from a different material. In one embodiment, the coupling piece <b>72</b> may be formed from a collar, such as a radiopaque band, that surrounds and secures the mesh structure <b>22</b> to an exterior surface of the elongated shaft <b>16</b>. In other embodiments, however, the coupling piece <b>72</b> may have a different arrangement and/or include different features.

p-0082<figref idrefs="DRAWINGS">FIG. 7</figref> is a side view of the mesh structure of <figref idrefs="DRAWINGS">FIG. 6</figref> in an expanded configuration. Referring to <figref idrefs="DRAWINGS">FIGS. 6 and 7</figref> together, when not inserted into a patient, the mesh structure <b>22</b> is capable of expanding to a maximum diameter <b>82</b> that is larger than the collapsed diameter <b>62</b>. Further, the mesh structure <b>22</b> may be sized so that the maximum diameter <b>82</b> is larger than the lumen diameter <b>52</b> of the renal artery. In some embodiments, for example, when inserted into a patient, the mesh structure <b>22</b> expands radially to span the renal artery lumen. In such an example, the largest transverse dimension of the mesh structure <b>22</b> is approximately or slightly less than (e.g., in embodiments in which the energy delivery element <b>24</b> fills some of the space) the diameter <b>52</b> of the renal artery lumen. A slight amount of vessel distension may be caused without undue injury and a mesh structure <b>22</b> may expand such that its largest transverse dimension is slightly more than the natural lumen diameter <b>52</b> of the renal artery, or such that an energy deliver element is slightly pressed into the wall of the renal artery. A mesh structure that causes slight and non-injurious distension of an artery wall may advantageously provide stable contact force between the energy delivery element <b>24</b> and the artery wall and/or hold the energy delivery element in place even as the artery moves with respiratory motion and pulsing blood flow. In further embodiments, the lumen diameter <b>52</b> can restrict the expansion of the mesh structure <b>22</b> and provide a limit to the maximum diameter <b>82</b>. This restriction can cause the mesh structure <b>22</b> to form more of a cylindrical tapered shape than the prolate spheroid shape illustrated in <figref idrefs="DRAWINGS">FIG. 7</figref>. Because this lumen diameter <b>52</b> varies from patient to patient, the mesh structure <b>22</b> may be capable of assuming a range of diameters between the compressed diameter <b>62</b> and the maximum diameter <b>82</b>.

p-0083The mesh structure <b>22</b> in the expanded configuration may be characterized by its length <b>80</b> along the axis of the elongated shaft <b>16</b>. In the depicted embodiment, only the proximal end <b>42</b> of the mesh structure <b>22</b> is coupled to the elongated shaft. As the mesh structure <b>22</b> expands, its diameter increases and its length decreases. That is, when the mesh structure expands, the distal end <b>44</b> moves axially towards the proximal end <b>42</b>. Accordingly, the expanded length <b>80</b> can be less than the unexpanded, or collapsed, length <b>64</b> (see <figref idrefs="DRAWINGS">FIG. 10</figref>). In certain embodiments, only one of the proximal end <b>42</b> or the distal end <b>44</b> of the mesh structure is fixedly coupled to the elongated shaft <b>16</b>. In such a configuration, the distance between the proximal end <b>42</b> and the distal end <b>44</b> changes as the mesh structure <b>22</b> moves between the expanded and collapsed configurations. In further non-braided mesh embodiments, the length <b>80</b> does not decrease with the expansion of the mesh structure <b>22</b>. As discussed further below with reference to <figref idrefs="DRAWINGS">FIG. 8</figref>, for example, a delivery sheath can be used for deploying the mesh structure <b>22</b>; in some embodiments the mesh structure <b>22</b> can self-expand and lengthen when the delivery sheath is retracted.

p-0084The dimensions of the mesh structure <b>22</b> are influenced by its physical characteristics and its configuration (e.g., expanded vs. unexpanded), which in turn may be selected with renal artery geometry in mind. For example, the axial length of the mesh structure <b>22</b> may be selected to be no longer than a patient's renal artery. Dimensions of the renal artery may be derived from textbooks of human anatomy, augmented with a clinician's knowledge of the site generally or as derived from prior analysis of the particular morphology of the targeted site. For example, the distance between the access site and the junction of the aorta and renal artery (e.g. the distance from a femoral access site to the renal artery is typically approximating about 40 cm to about 55 cm) is generally greater than the length of a renal artery between the aorta and the most distal treatment site along the length of the renal artery, which is typically less than about 7 cm. Accordingly, it is envisioned that the elongated shaft <b>16</b> is at least 40 cm and the mesh structure is less than about 7 cm in its unexpanded length <b>64</b>, for example. A length in an unexpanded configuration of no more than about 4 cm may be suitable for use in a large population of patients and provide a long contact area in an expanded configuration and in some embodiments provide a long region for placement of multiple energy delivery elements; however, a shorter length (e.g. less than about 2 cm) in an unexpanded configuration may be used in patients with shorter renal arteries. The mesh structure <b>22</b> may also be designed to work with typical renal artery lumen diameters. For example, the lumen diameter <b>52</b> of the renal artery may vary between about 2 mm and about 10 mm. In a particular embodiment, the placement of the energy delivery element <b>24</b> on the mesh structure <b>22</b> may be selected with regard to an estimated location of the renal plexus relative to the renal artery.

p-0085As noted, the expanded configuration length <b>80</b> of the mesh structure <b>22</b> is less than the length <b>64</b> in the compressed configuration. In some embodiments, the length <b>80</b> may be less than about 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, or 90% of the compressed length <b>64</b>. Further, in some embodiments, the expanded configuration diameter <b>82</b> may be at least 1.2×, 1.25×, 1.5, 1.75×, 2×, 2.25×, 2.5×, 2.75×3×, 3.25×, 3.5×, 3.75×, 4×, 4.25×, 4.5×, 4.75×, or 5× the compressed diameter <b>62</b>.

p-0086The dimensions of the mesh structure <b>22</b> may be taken into account. That is, a typical renal artery may constrict, dilate or move relative to the aorta in response to blood flow changes or changes in a patient's breathing, etc. The mesh structure <b>22</b> may be selected to be used in conjunction with a particular renal artery lumen diameter <b>52</b>, taking into account that this lumen diameter <b>52</b> may change (e.g., up to 20%) during the time that the mesh structure is in place. As such, the largest unconstrained diameter <b>82</b> of the mesh structure <b>22</b> may be sufficiently oversized relative to the renal artery to allow for additional expansion during use. In one embodiment, the unconstrained diameter <b>82</b> may be at least 1.2×, 1.5×, or 2× an estimated renal artery lumen diameter <b>52</b>. In addition, as provided herein, stable contact with the renal artery is facilitated by the contact force of the mesh structure <b>22</b> against the renal artery wall <b>55</b>. This contact force is influenced by the materials and construction of the mesh structure <b>22</b>. The mesh structure <b>22</b> may be able to provide a substantially constant/stable contact force against the renal artery wall <b>55</b> within a particular range of diameters that the renal artery and the inserted mesh structure <b>22</b> jointly assume. In a particular embodiment, the contact force may be substantially stable over a range of diameters for example, between about 3 mm-5 mm, 5 mm-8 mm, or 6 mm-10 mm. In another embodiment the contact force may be suitable over a range of 2 mm-10 mm by controlling the amount of expansion or by suitable exertion of expansion force created by a self expanding mesh structure, for example by a mesh structure fabricated with super-elastic material such as nickel titanium alloy (nitinol) or composite nitinol with polymer coating for insulation.

p-0087<tables id="TABLE-US-00001" num="00001"><table frame="none" colsep="0" rowsep="0" pgwide="1"><tgroup align="left" colsep="0" rowsep="0" cols="1"><colspec colname="1" colwidth="259pt" align="center" /><thead><row><entry namest="1" nameend="1" rowsep="1">TABLE 1</entry></row></thead><tbody valign="top"><row><entry namest="1" nameend="1" align="center" rowsep="1" /></row><row><entry>Examples of approximate dimensions of mesh structures</entry></row><row><entry>in expanded and unexpanded configurations.</entry></row></tbody></tgroup><tgroup align="left" colsep="0" rowsep="0" cols="5"><colspec colname="1" colwidth="49pt" align="center" /><colspec colname="2" colwidth="56pt" align="center" /><colspec colname="3" colwidth="56pt" align="center" /><colspec colname="4" colwidth="56pt" align="center" /><colspec colname="5" colwidth="42pt" align="center" /><tbody valign="top"><row><entry>Expanded</entry><entry>Expanded</entry><entry /><entry>Expanded</entry><entry /></row><row><entry>configuration</entry><entry>configuration</entry><entry>Compressed</entry><entry>configuration</entry><entry>Compressed</entry></row><row><entry>diameter</entry><entry>diameter</entry><entry>configuration</entry><entry>axial length</entry><entry>configuration</entry></row><row><entry>(in patient)</entry><entry>(outside patient)</entry><entry>diameter</entry><entry>(outside patient)</entry><entry>axial length</entry></row><row><entry namest="1" nameend="5" align="center" rowsep="1" /></row><row><entry>2 mm-8 mm</entry><entry>3 mm-12 mm</entry><entry>&lt;2 mm-&lt;2.18mm</entry><entry>&lt;36 mm</entry><entry>&lt;40 mm</entry></row><row><entry>3 mm-8 mm</entry><entry>5 mm-10 mm</entry><entry>&lt;2.18 mm</entry><entry>&lt;30 mm-&lt;36 mm</entry><entry>&lt;40 mm</entry></row><row><entry>6 mm-8 mm</entry><entry>8 mm-10 mm</entry><entry>&lt;2.18 mm</entry><entry>&lt;32 mm</entry><entry>&lt;40 mm</entry></row><row><entry>5 mm-8 mm</entry><entry>6 mm-10 mm</entry><entry>&lt;2.18 mm</entry><entry>&lt;30 mm</entry><entry>&lt;40 mm</entry></row><row><entry>3 mm-5 mm</entry><entry>5 mm-8 mm </entry><entry>&lt;2.18 mm</entry><entry>&lt;30 mm</entry><entry>&lt;40 mm</entry></row><row><entry namest="1" nameend="5" align="center" rowsep="1" /></row></tbody></tgroup></table></tables>

p-0088A. Formation of the Mesh Structure

p-0089Referring to <figref idrefs="DRAWINGS">FIGS. 6 and 7</figref> together, the mesh structure <b>22</b> includes structural elements, e.g., strands, wires, filaments or fibers <b>58</b>, arranged to define interstices or interstitial spaces <b>57</b> there between. As provided above, the mesh structure <b>22</b> may be characterized by its axial length (e.g., an axial length in an expanded configuration or unexpanded configuration, either inside or outside the patient) or its diameter (e.g., a largest diameter in an expanded or unexpanded configuration, either inside or outside the patient). In addition, the mesh structure <b>22</b> may be characterized by the structural elements from which it is formed. Because the change in diameter and length between the expanded configuration and the collapsed configuration may involve realignment of strands <b>58</b> and changes in the geometry of the interstitial spaces <b>57</b>, the makeup of the strands <b>58</b> and the geometry of the interstitial spaces <b>57</b> may at least in part define how much the diameter and length of the mesh structure <b>22</b> change as a result of configuration changes.

p-0090The fibers <b>58</b> may be formed from biocompatible metals, polymers, or composites. For example, suitable metals can include stainless steel, spring steel, cobalt chromium, gold, platinum, platinum-iridium, stainless steel, or combinations thereof. In embodiments in which the fibers <b>58</b> are composed solely of metal, the entire mesh structure <b>22</b> can comprise the electrode <b>24</b>. For example, in one particular embodiment, the mesh structure <b>22</b> may be composed of nitinol with gold plating to enhance radiopacity and/or conductivity. Suitable polymer materials can include, for example, polyethylene terephthalate (PET), polyamide, polyimide, polyethylene block amide copolymer, polypropylene, or polyether ether ketone (PEEK) polymers. In still further embodiments, the mesh structure <b>22</b> may be a combination of electrically conductive and nonconductive materials.

p-0091In addition, in particular embodiments, the mesh structure <b>22</b> may be formed at least in part from radiopaque materials that are capable of being imaged fluoroscopically to allow a clinician to determine if the mesh structure <b>22</b> is appropriately placed and/or deployed in the renal artery. Radiopaque materials may include barium sulfate, bismuth trioxide, bismuth subcarbonate, powdered tungsten, powdered tantalum, or various formulations of certain metals, including gold and platinum, and these materials may be directly incorporated into the fibers <b>58</b> or may form a partial or complete coating of the mesh structure <b>22</b>.

p-0092Generally, the mesh structure <b>22</b> may be designed to apply a desired outward radial force to a renal artery wall when inserted and expanded to contact the inner surface of the renal artery wall <b>55</b>. The radial force may be selected to avoid injury from stretching or distending the renal artery when the mesh structure <b>22</b> is expanded against an artery wall within the patient. Radial forces that may avoid injuring the renal artery yet provide adequate stabilization force may be determined by calculating the radial force exerted on an artery wall by typical blood pressure. For example, a suitable radial force may be less than about 300 mN/mm (e.g. less than 200 mN/mm). In other embodiments, however, the radial force can vary. Factors that may influence the applied radial force include the geometry and the stiffness of the mesh structure <b>22</b>. In one particular embodiment, for example, the fibers <b>58</b> are about 0.005-0.009 inch (0.330-1.23 mm) in diameter. Depending on the composition of the fibers <b>58</b>, the fiber diameters and quantity of fibers may be selected to facilitate a desired conformability and/or radial force against the renal artery when expanded. For example, fibers <b>58</b> formed from stiffer materials (e.g. metals) may be thinner relative to fibers <b>58</b> formed highly flexible polymers to achieve similar flexibilities and radial force profiles. The outward pressure of the mesh structure <b>22</b> may be assessed in vivo by an associated pressure transducer.

p-0093Mesh structures <b>22</b> with open structures (e.g., low material-per-square-inch ratios) may have less radial stiffness and strength than more closed structures (or high material density structures). The fiber thickness also affects outward pressure, radial strength and stiffness. A thicker fiber <b>58</b> provides greater radial strength and stiffness compared with a relatively thinner fiber <b>58</b> of the same material. However, a stiffer fiber material may compensate for a generally open braid structure. In addition, certain secondary processes, including heat treating and annealing, may harden or soften the fiber material to affect strength and stiffness. In particular, for shape-memory alloys such as nitinol, these secondary processes may be varied to give the same starting material different final properties. For example, the elastic range or softness may be increased to impart improved flexibility. The secondary processing of shape memory alloys influences the transition temperature, i.e., the temperature at which the structure exhibits a desired radial strength and stiffness. This temperature may be set at normal body temperature (e.g., 37° C.).

p-0094The mesh structure <b>22</b> may be laser cut, braided, knit, or woven to form a conformable structure (e.g., a tubular, barrel-shaped, parachute-shaped, or spherical structure) through which fluids may pass. In embodiments in which the mesh structure <b>22</b> is braided, the characteristics of the structure <b>22</b> may be influenced by the number of fibers. In a particular embodiment, the mesh structure <b>22</b> may have 8-96 fibers. It should be understood that a fiber may be formed from a single filament (monofilament) or by a plurality of filaments twisted or otherwise grouped together to form a multifilar fiber. In addition, the mesh structure <b>22</b> may be characterized by its braid pitch, which in embodiments may be between 10-90 picks (i.e., windings) per inch (3.9-35.5 picks per cm) or by its braid angle, defined as the angle between two intersecting braid strands and encompassing a longitudinal axis of the mesh structure <b>22</b>. The braid angle of the mesh structure <b>22</b> in its expanded configuration may be in the range of 20° to 160° (e.g. about 100°). Further, the mesh structure <b>22</b> may be helically braided (e.g., clockwise and counterclockwise helices) into a generally ovoid, tubular, barrel, or other shaped structure. Additionally, the type of braiding process used to form the mesh structure <b>22</b> may influence its compressibility. For example, filaments braided in a pattern known as “two over and two under” will have greater bending stiffness than a simpler “one over and one under” pattern.

p-0095It should be understood that the mesh structure <b>22</b> may be generally symmetrical and coaxial with respect to the elongated shaft <b>16</b>. However, it is also contemplated that the mesh structure <b>22</b> may be preformed to conform to any irregularities in the renal artery, which may be assessed by imaging or other techniques. For example, particular sizes and types of mesh structures may be used in conjunction with a patient's particular anatomic features.

p-0096B. Additional Embodiments of Treatment Devices Having Mesh Structures

p-0097<figref idrefs="DRAWINGS">FIGS. 8-12B</figref> illustrate additional embodiments of treatment devices including expandable mesh structures configured in accordance with embodiments of the technology. The embodiments described below may have many of the same or similar features as the treatment devices described above, and may be used with the system <b>10</b> or other suitable systems for renal neuromodulation. Further, the embodiments provided herein include features that may be combined with one another and with the features of other disclosed embodiments. In an effort to provide a concise description of these embodiments, not all features of an actual implementation are described herein.

p-0098<figref idrefs="DRAWINGS">FIG. 8</figref>, for example, illustrates a treatment device <b>812</b> used in conjunction with a delivery sheath <b>91</b> surrounds a mesh structure <b>822</b> and the elongated shaft <b>16</b>. As noted above, in certain embodiments it may be advantageous to use a guide catheter <b>90</b> of a particular size to facilitate insertion of the treatment device <b>812</b> through the femoral artery. A delivery sheath <b>91</b> may be used in conjunction with a guide catheter <b>90</b> to gain access to a renal artery and deliver a radially constrained expandable mesh structure <b>822</b>. Alternatively, a delivery sheath <b>91</b> may be used in conjunction with a guide wire (e.g., the guide wire <b>66</b> illustrated in <figref idrefs="DRAWINGS">FIG. 7</figref>). When used in conjunction with a guide catheter <b>90</b>, a working length of the elongated shaft <b>16</b> may be about 40 cm to about 125 cm. If, for example, a 55 cm length guide catheter is used, then this working length of the shaft <b>16</b> may be about 70 cm to about 80 cm. If a 90 cm length guide catheter is used, then this shaft working length may be about 105 cm to about 115 cm.

p-0099In the depicted embodiment, the mesh structure <b>822</b> may be held in the radially compressed configuration by the delivery sheath <b>91</b>. Removal of the delivery sheath <b>91</b> allows the mesh structure <b>822</b> to expand radially so that the energy delivery element <b>24</b> is in proper apposition with the inner wall of the renal artery for energy delivery. The expansion may be passive (e.g., the mesh structure may be self-expanding or may expand as the mesh structure is filled with blood) or active (e.g., the expansion is facilitated by an interior balloon or fluid injection into the interior space of the mesh structure <b>822</b>, or by a tension or control wire pulling on the distal end and/or pushing on the proximal end of a mesh structure <b>822</b> reducing its length to expand its diameter) Regardless of the type of expansion, the mesh structure <b>822</b> may by coupled to a control wire (e.g., the control wire <b>68</b> illustrated in <figref idrefs="DRAWINGS">FIG. 6</figref>) that may aid in compressing the mesh structure <b>822</b> prior to removal or repositioning of the treatment device <b>812</b>. In particular embodiments, depending on the placement and number of energy delivery elements <b>24</b>, the mesh structure <b>822</b> may be selectively repositioned within the renal artery to provide a number of locations for energy delivery. The mesh structure <b>822</b> is expected to provide stable contact of the energy delivery element <b>24</b> with the inner wall of the renal artery without occluding the blood flow within the artery. To that end, the mesh structure <b>822</b> may be shaped to include open areas to help maintain normal blood flow.

p-0100<figref idrefs="DRAWINGS">FIG. 9</figref> illustrates a mesh structure <b>922</b> having an opening <b>994</b> at a distal end <b>44</b>. A proximal end <b>42</b> of the mesh structure <b>922</b> is coupled to the elongated shaft <b>16</b>, while the distal end <b>44</b> terminates in a terminal circumferential section <b>92</b> that is approximately the same diameter as the renal artery lumen diameter <b>52</b>. The terminal circumferential section <b>92</b> may be bound or otherwise woven to eliminate any protruding fiber ends. In addition, a terminal circumferential section <b>92</b> may be relatively stiffer to prevent folding the free distal end <b>44</b>. The substantially cylindrical mesh configuration <b>922</b> may provide more surface area for contacting the renal artery inner wall as compared to a more ball-shaped mesh structure, thus providing more potential surface area for mounting energy delivery elements <b>24</b>.

p-0101Alternatively, as shown in <figref idrefs="DRAWINGS">FIG. 10</figref>, a mesh structure <b>1022</b> may be shaped to include a relatively smaller distal opening <b>96</b> sized for receiving the guide wire <b>66</b> and limiting lateral deflection of the guide wire <b>66</b>. The mesh in a neck <b>97</b> of the opening <b>96</b> may be relatively stiffer to help hold the guide wire <b>66</b> in place similar to the end piece <b>74</b> illustrated in <figref idrefs="DRAWINGS">FIG. 7</figref>. In some embodiments, this arrangement can help maintain a desired alignment between the mesh structure <b>1022</b> and the vessel. (e.g., the mesh structure <b>1022</b> remains approximately centered in the artery with wall apposition forces substantially evenly displaced over its surface). <figref idrefs="DRAWINGS">FIG. 11</figref> shows an embodiment in which a mesh structure <b>1122</b> includes a closed end <b>98</b>.

p-0102As noted previously, expansion of the mesh structure may be facilitated by blood flood within the renal artery. <figref idrefs="DRAWINGS">FIG. 12A</figref>, for example, illustrates an embodiment in which the distal end <b>44</b> of a mesh structure <b>1222</b><i>a </i>is closed and the open proximal end <b>42</b> is axially spaced apart from the distal end of the elongated shaft <b>16</b>. The blood flow depicted by arrows <b>106</b> may flow into the opening <b>100</b> to open the umbrella-like or parachute-like mesh structure <b>1222</b><i>a </i>with hydrodynamic force, pushing the energy delivery element <b>24</b> against the renal artery wall. The proximal end <b>42</b> of the mesh structure <b>1222</b><i>a </i>is coupled to the elongated shaft <b>16</b> via tethers or wires <b>104</b>. In some embodiments, for example, the wires <b>104</b> may facilitate retraction of the mesh structure <b>1222</b><i>a </i>into a delivery sheath for removal or repositioning. In another embodiment, the distal end <b>44</b> of the mesh structure <b>1222</b><i>a</i>, rather than the proximal end <b>42</b>, is coupled to the elongated shaft <b>16</b> via tethers that, when pulled, expand the mesh structure <b>22</b>. In still further embodiments, the mesh structure <b>1222</b><i>a </i>is wired or tethered to the shaft <b>16</b> at both the proximal <b>42</b> and distal ends <b>44</b> and the mesh structure <b>1222</b><i>a </i>may be expanded or collapsed by moving the tether attachment points on the proximal end <b>42</b> and distal end <b>44</b> relative to each other (e.g., the distal end <b>44</b> could be pulled proximally to expand and pushed distally to collapse; the proximal end <b>42</b> could be pushed distally to expand or pulled proximally to collapse).

p-0103Referring next to <figref idrefs="DRAWINGS">FIG. 12B</figref>, a mesh structure <b>1222</b><i>b </i>configured in accordance with another embodiment of the technology may have an opening <b>1294</b> at the distal end <b>44</b> in addition to the opening <b>100</b> at the proximal end <b>42</b> to allow maximum blood flow therethrough. In further embodiments, both ends of the mesh structure <b>1222</b><i>b </i>can be closed and/or tethered to the elongated shaft <b>16</b>. In this embodiment the mesh may be self expanding. For example, the mesh structure <b>1222</b><i>b </i>may be made from an elastic or super elastic material such as nitinol or spring temper stainless steel and have an unrestrained configuration comprising an expanded diameter. The self expanding mesh structure <b>1222</b><i>b </i>may be deployed by retracting a delivery sheath <b>91</b> to remove constraining forces. The self expanding mesh structure <b>1222</b><i>b </i>may be compressed by retraction into the delivery sheath facilitated by pulling the wires <b>104</b>. Wires <b>104</b> may further be beneficial by providing a flexible connection between the mesh structure <b>1222</b><i>b </i>and the distal end of the elongated shaft <b>16</b> such that if the distal end of the elongated shaft is eccentrically positioned within the artery, then the mesh structure <b>1222</b><i>b </i>remains centered in the artery with wall apposition forces substantially evenly displaced over its surface.

p-0104C. Size and Configuration of the Energy Delivery Element(s)

p-0105It will be appreciated that the embodiments provided herein may be used in conjunction with one or more energy delivery elements <b>24</b>. Referring to <figref idrefs="DRAWINGS">FIGS. 1-7</figref> together, for example, the energy delivery element <b>24</b> associated with the mesh structure <b>22</b> may be a separate element or may be an integral part of the mesh structure <b>22</b>. In some patients, it may be desirable to use the energy delivery element(s) <b>24</b> to create either a single lesion or a pattern of multiple focal lesions that are spaced apart circumferentially and/or axially along the longitudinal axis of the renal artery. A single focal lesion with desired longitudinal and/or circumferential dimensions, one or more full circumferential lesions, multiple circumferentially spaced focal lesions at a common longitudinal position, spiral-shaped lesions, interrupted spiral lesions, generally linear lesions, and/or multiple longitudinally spaced focal lesions along a line parallel to the axis of the renal artery alternatively or additionally may be created. In still further embodiments, the energy delivery element(s) <b>24</b> may be used to create lesions having a variety of other geometric shapes or patterns.

p-0106Depending on the size, shape, and number of the energy delivery elements <b>24</b>, the lesions created may be circumferentially spaced around the renal artery, either in a single transverse plane or the lesions may also be spaced apart longitudinally. In particular embodiments, it is desirable for each lesion to cover at least 10% of the vessel circumference to increase the probability of affecting the renal plexus. It is also desirable that each lesion be sufficiently deep to penetrate into and beyond the adventitia to thereby affect the renal plexus. However, lesions that are too deep run the risk of interfering with non-target tissue and tissue structures (e.g., the renal vein) so a controlled depth of energy treatment is also desirable.

p-0107In certain embodiments, the energy delivery element <b>24</b> may be circumferentially repositioned relative to the renal artery during treatment. This angular repositioning may be achieved, for example, by compressing the mesh structure and rotating the elongated shaft <b>16</b> of treatment device <b>12</b> via handle assembly <b>34</b>. In addition to the angular or circumferential repositioning of the energy delivery element <b>24</b>, the energy delivery element <b>24</b> optionally may also be repositioned along the lengthwise or longitudinal dimension of the renal artery. This longitudinal repositioning may be achieved, for example, by translating the elongated shaft <b>16</b> of the treatment device <b>12</b> via the handle assembly <b>34</b>, and may occur before, after, or concurrently with angular repositioning of the energy delivery element <b>24</b>. Repositioning the energy delivery element <b>24</b> in both the longitudinal and angular dimensions places the energy delivery element in contact with the interior wall of the renal artery at a second treatment site for treating the renal plexus. Energy then may be delivered via the energy delivery element <b>24</b> to form a second focal lesion at this second treatment site. For embodiments in which multiple energy delivery elements <b>24</b> are associated with the mesh structure, the initial treatment may result in two or more lesions, and repositioning may allow additional lesions to be created. One or more additional focal lesions optionally may be formed via additional repositioning of the mesh structure <b>22</b>.

p-0108In certain embodiments, the lesions created via repositioning of the mesh structure <b>22</b> are circumferentially and longitudinally offset from the initial lesion(s) about the angular and lengthwise dimensions of the renal artery, respectively. The composite lesion pattern created along the renal artery by the initial energy application and all subsequent energy applications after any repositioning of the energy delivery element(s) <b>24</b> may effectively result in a discontinuous lesion (i.e., it is formed from multiple, longitudinally and angularly spaced treatment sites). To achieve denervation of the kidney, it may be desirable for the composite lesion pattern, as viewed from a proximal or distal end of the vessel, to extend at least approximately all the way around the circumference of the renal artery. In other words, each formed lesion covers an arc of the circumference, and each of the lesions, as viewed from an end of the vessel, abut or overlap adjacent lesions to create a virtually circumferential lesion. The formed lesions defining an actual circumferential lesion lie in a single plane perpendicular to a longitudinal axis of the renal artery. A virtually circumferential lesion is defined by multiple lesions that may not all lie in a single perpendicular plane, although more than one lesion of the pattern can be so formed. At least one of the formed lesions comprising the virtually circumferential lesion is axially spaced apart from other lesions. In a non-limiting example, a virtually circumferential lesion can comprise six lesions created in a single helical pattern along the renal artery such that each lesion spans an arc extending along at least one sixth of the vessel circumference such that the resulting pattern of lesions completely encompasses the vessel circumference, when viewed from an end of the vessel. In other examples, however, a virtually circumferential lesion can comprise a different number of lesions

p-0109In one example, as shown in <figref idrefs="DRAWINGS">FIG. 13</figref>, a mesh structure <b>1322</b> (e.g., an open or closed-ended structure) may function as an expandable member to radially push multiple energy delivery elements <b>24</b> coupled to leads <b>110</b> against the inner wall of the renal artery. In the depicted embodiment, the leads <b>110</b> may be separate from the mesh structure <b>1322</b>, or may be loosely coupled or integrated into to the mesh structure <b>1322</b> to prevent twisting or kinking of the leads <b>110</b>. In particular embodiments, to facilitate the stable contact of the energy delivery element <b>24</b> in the renal artery, the energy delivery element <b>24</b> may be coupled to a mesh structure <b>1422</b> by weaving a lead <b>116</b> into the fibers <b>58</b> of the mesh or threading leads <b>116</b> through interstices in the mesh, as shown in <figref idrefs="DRAWINGS">FIG. 14</figref>. The energy delivery elements <b>24</b> are positioned on an exterior surface <b>118</b> or in spaces of the mesh structure <b>1422</b>. The positioning of the energy delivery elements <b>24</b> on the exterior surface <b>118</b> may be associated with a desired lesion pattern. Alternatively, as shown in <figref idrefs="DRAWINGS">FIG. 15</figref>, the energy delivery element <b>24</b> may be directly coupled to the fibers <b>58</b> of a mesh structure <b>1522</b>. The energy delivery element <b>24</b> is coupled to one or more fibers <b>58</b>, for example via adhesion or threading a fiber <b>58</b> through an internal bore <b>120</b>.

p-0110In an alternative embodiment, the energy delivery element <b>24</b> may be in the form of an electrically conductive wire or cable, e.g., a ribbon electrode. As shown in <figref idrefs="DRAWINGS">FIG. 16</figref>, the ribbon electrode <b>1624</b> may be wound about a mesh structure <b>1622</b> or may be woven into or otherwise coupled to the mesh structure <b>1622</b>. The ribbon electrode <b>1624</b> may provide increased surface area for delivering energy. For example, the ribbon electrode <b>1624</b> may form a helical lesion in a single energy application. Accordingly, the mesh structure <b>1622</b> may be capable of providing sufficient renal denervation with a single energy application at a single location. The ribbon electrode <b>1624</b> may be wound in any manner about the mesh structure <b>1622</b>, depending on the desired lesion to be formed. For example, the ribbon electrode <b>1624</b> may form a loose-pitch or tight-pitch helix. In addition, the winding may be tight against the mesh structure <b>1622</b>, so that the ribbon electrode <b>1624</b> generally follows the contours of the mesh structure <b>1622</b>. In other embodiments, slack portions of the ribbon electrode <b>1624</b> may be pulled into the interior space to allow the forming of discontinuous lesions. Further, in such an arrangement, regions of the ribbon electrode <b>1624</b> that do not contact the renal artery wall may contribute to cooling of the energy delivery element <b>24</b>, as provided herein. Alternatively, as shown in <figref idrefs="DRAWINGS">FIG. 17</figref>, only portions <b>130</b> of the ribbon electrode <b>1624</b> may be electrically conductive with the vessel tissue. That is, the ribbon electrode <b>1624</b> can include insulated portions <b>131</b> and uninsulated portions <b>130</b> in which the insulation is removed. The positioning and number of stripped portions <b>130</b> forming the energy delivery elements <b>1624</b> may be selected according to a desired lesion pattern to be formed.

p-0111As noted, one or more energy delivery elements <b>24</b> may be associated with the mesh structure <b>22</b> for forming a particular lesion pattern. As shown in <figref idrefs="DRAWINGS">FIG. 18</figref>, energy delivery elements <b>24</b><i>a</i>, <b>24</b><i>b</i>, and <b>24</b><i>c </i>may be distributed on the mesh structure <b>1822</b>. The axial distances (e.g., distances <b>140</b> and <b>142</b> in <figref idrefs="DRAWINGS">FIG. 19</figref>) between axially adjacent energy delivery elements <b>24</b> may be selected so that the edges of the lesions formed by each individual energy delivery elements <b>24</b> on the renal artery wall <b>55</b> are either overlapping or nonoverlapping. One or both of the axial distances <b>140</b> or <b>142</b> may be about 2 mm to about 1 cm. In a particular embodiment, the axial distances <b>140</b> or <b>142</b> may be in the range of about 2 mm to about 5 mm. In another representative embodiment, the axially adjacent energy delivery elements <b>24</b> may be spaced apart about 30 mm. In another representative embodiment, the axially adjacent energy delivery elements <b>24</b> are spaced apart about 11 mm. In still another representative embodiment, the axially adjacent energy delivery elements <b>24</b> are spaced apart about 17.5 mm. Further, the axial distance <b>140</b> may be less than, about equal to, or greater than the axial distance <b>142</b>.

p-0112In some embodiments, the energy delivery elements <b>24</b> are both longitudinally and circumferentially offset from one another. For example, <figref idrefs="DRAWINGS">FIG. 20A</figref> is an end view of a mesh structure <b>2022</b>A in which the energy delivery elements <b>24</b><i>a</i>-<b>24</b><i>c </i>are affixed to the mesh pattern in such an arrangement that element <b>24</b><i>c </i>is circumferentially offset from energy delivery element <b>24</b><i>a </i>by angle <b>150</b> and circumferentially offset from energy delivery element <b>24</b><i>b </i>by angle <b>152</b>. <figref idrefs="DRAWINGS">FIG. 20B</figref> is a side view of the mesh structure <b>2022</b>A illustrating the energy delivery elements <b>24</b><i>a</i>, <b>24</b><i>b</i>, and <b>24</b><i>c </i>in a generally circumferentially aligned arrangement. <figref idrefs="DRAWINGS">FIG. 20C</figref> is an end view of a generally cylindrical mesh structure <b>2022</b>B having energy delivery elements affixed to the mesh structure <b>2022</b>B in a helical pattern such that elements <b>24</b><i>d</i>-<b>24</b><i>h </i>are circumferentially and axially offset from one another. <figref idrefs="DRAWINGS">FIG. 20D</figref> is a side view of the mesh structure <b>2022</b>B. The circumferential offset arcs, or corresponding radial angles may be selected so that when energy is applied to the renal artery via energy delivery elements <b>24</b><i>d</i>-<b>24</b><i>h</i>, a roughly helical lesion pattern is formed therein. Depending on the number and positioning of the energy delivery elements <b>24</b> selectively mounted on mesh structure <b>2022</b>B, a helical lesion pattern with any desired number of turns may be formed with treatment device <b>12</b> using only a single energy application. In other embodiments, the energy delivery elements <b>24</b> may have a variety of different arrangements relative to each other (e.g., linear, interrupted helix, continuous helix).

p-0113As discussed previously, the energy delivery element <b>24</b> is sized and configured to contact an internal wall of the renal artery during operation. For example, referring back to <figref idrefs="DRAWINGS">FIGS. 1 and 2</figref>, the energy delivery element <b>24</b> may take the form of an electrode sized and configured to apply an electrical field of RF energy from the energy generator <b>26</b> (<figref idrefs="DRAWINGS">FIG. 1</figref>) to a vessel wall. The energy delivery element <b>24</b> may be operated in a monopolar or unipolar mode. In this arrangement, a return path for the applied RF electric field is established, e.g., by an external dispersive electrode (e.g., the external dispersive electrode <b>38</b> in <figref idrefs="DRAWINGS">FIGS. 1 and 2</figref>), also called an indifferent electrode or neutral electrode. The monopolar application of RF electric field energy serves to ohmically or resistively heat tissue in the vicinity of the electrode <b>24</b>. The application of the RF electrical field thermally injures tissue. The treatment objective is to thermally induce neuromodulation (e.g., necrosis, thermal alteration or ablation) in the targeted neural fibers. The thermal injury forms a lesion in the vessel wall. Alternatively, a RF electrical field may be delivered with an oscillating intensity that does not thermally injure the tissue whereby neuromodulation in the targeted nerves is accomplished by electrical modification of the nerve signals.

p-0114The active surface area of the energy delivery element <b>24</b> is defined as the energy transmitting area of the element <b>24</b> that may be placed in intimate contact against tissue. Too much contact between the energy delivery element and the vessel wall may create unduly high temperatures at or around the interface between the tissue and the energy delivery element, thereby creating excessive heat generation at this interface. This excessive heat may create a lesion that is circumferentially too large. This may also lead to undesirable thermal application to the vessel wall. In some instances, too much contact can also lead to small, shallow lesions. Too little contact between the energy delivery element and the vessel wall may result in superficial heating of the vessel wall, thereby creating a lesion that is too small (e.g., &lt;10% of vessel circumference) and/or too shallow.

p-0115The active surface area (ASA) of contact between the energy delivery element <b>24</b> and the inner vessel wall (e.g., the renal artery wall <b>55</b> of <figref idrefs="DRAWINGS">FIGS. 3-5</figref>) has great bearing on the efficiency and control of the generation of a thermal energy field across the vessel wall to thermally affect targeted neural fibers in the renal plexus RP. While the active surface area (ASA) of the energy delivery element is important to creating lesions of desirable size and depth, the ratio between the active surface area (ASA) and total surface area (TSA) of the energy delivery element <b>24</b> and electrode <b>46</b> is also important. The ASA to TSA ratio influences lesion formation in two ways: (1) the degree of resistive heating via the electric field, and (2) the effects of blood flow or other convective cooling elements such as injected or infused saline. For example, an RF electric field causes lesion formation via resistive heating of tissue exposed to the electric field. The higher the ASA to TSA ratio (i.e., the greater the contact between the electrode and tissue), the greater the resistive heating, e.g., the larger the lesion that is formed. As discussed in greater detail below, the flow of blood over the non-contacting portion of the electrode (TSA minus ASA) provides conductive and convective cooling of the electrode, thereby carrying excess thermal energy away from the interface between the vessel wall and electrode. If the ratio of ASA to TSA is too high (e.g., more than 50%), resistive heating of the tissue may be too aggressive and not enough excess thermal energy is being carried away, resulting in excessive heat generation and increased potential for stenotic injury, thrombus formation and undesirable lesion size. If the ratio of ASA to TSA is too low (e.g., 10%), then there is too little resistive heating of tissue, thereby resulting in superficial heating and smaller and shallower lesions. In a representative embodiment, the ASA of the energy delivery elements <b>24</b> contacting tissue may be expressed as

p-0116<br />0.25TSA≦ASA≦0.50TSA

p-0117An ASA to TSA ratio of over 50% may still be effective without excessive heat generation by compensating with a reduced power delivery algorithm and/or by using convective cooling of the electrode by exposing it to blood flow. As discussed further below, electrode cooling can be achieved by injecting or infusing cooling fluids such as saline (e.g., room temperature saline or chilled saline) over the electrode and into the blood stream.

p-0118Various size constraints for an electrode energy delivery element <b>24</b> may be imposed for clinical reasons by the maximum desired dimensions of the guide catheter, as well as by the size and anatomy of the renal artery lumen itself. Typically, the maximum outer diameter (or cross-sectional dimension for non-circular cross-section) of the energy delivery element <b>24</b> is the largest diameter encountered along the length of the elongated shaft <b>16</b> distal to the handle assembly <b>34</b>. As previously discussed, for clinical reasons, the maximum outer diameter (or cross-sectional dimension) of the energy delivery element <b>24</b> is constrained by the maximum inner diameter of the guide catheter through which the elongated shaft <b>16</b> is to be passed through the intravascular path <b>14</b>. For example, as provided above, assuming that an 8 French guide catheter (which has an inner diameter of approximately 0.091 inch or 2.31 mm) is, from a clinical perspective, the largest desired catheter to be used to access the renal artery, and allowing for a reasonable clearance tolerance between the energy delivery element <b>24</b> and the guide catheter, the maximum diameter of the electrode <b>46</b> is constrained to about 0.085 inch or 2.16 mm. In the event a 6 French guide catheter is used instead of an 8 French guide catheter, then the maximum diameter of the energy delivery element <b>24</b> is constrained to about 0.070 inch or 1.78 mm. In the event a 5 French guide catheter is used, then the maximum diameter of the energy delivery element <b>24</b> is constrained to about 0.053 inch or 1.35 mm.

p-0119In one embodiment, the energy delivery element <b>24</b> can take the form of a cylinder or a ball. Based upon these constraints and the aforementioned power delivery considerations, the energy delivery element <b>24</b> may have an outer diameter of from about 0.049 to about 0.051 inch (1.24 mm-1.30 mm). The energy delivery element <b>24</b> also may have a minimum outer diameter of about 0.020 inch or 0.51 mm to provide sufficient cooling and lesion size. In some embodiments, the energy delivery element <b>24</b> may have a length of about 1 mm to about 3 mm. In some embodiments in which the energy delivery element <b>24</b> is a resistive heating element, the energy delivery element <b>24</b> has a maximum outer diameter from about 0.049 to 0.051 inch (1.24 mm-1.30 mm) and a length of about 10 mm to 30 mm.

p-0120In other embodiments, cooling of the energy delivery element <b>24</b> may be facilitated by having an irregularly or asymmetrically shaped energy delivery element. For example, referring to <figref idrefs="DRAWINGS">FIGS. 21 and 22</figref>, an energy delivery element <b>24</b> positioned among fibers <b>58</b> of a mesh structure may have an active surface <b>170</b> configured to contact the renal artery wall <b>55</b> and an inactive surface <b>172</b>. The inactive surface <b>172</b> is larger than the active surface <b>170</b> because of asymmetry in the energy delivery element <b>24</b>. As shown in the illustrated embodiments, this may be because of a bulbous projection <b>174</b>, or because of surface projections <b>178</b> (e.g., teeth) that form an irregular inactive surface <b>172</b>. The inactive surface acts as a heat sink for the energy delivery element <b>24</b> because more surface area of the electrode energy delivery element <b>24</b> is exposed to the cooling blood flow. As such, in particular embodiments, the energy delivery element <b>24</b> may be formed in any shape in which the surface area of the inactive surface <b>172</b> is larger than the surface area of the active surface <b>170</b>. In alternative embodiments, a ribbon electrode energy delivery element <b>24</b> may be formed so that an inactive surface area is larger than an active surface area. As noted, this may be accomplished by forming a certain amount of slack into the winding and pulling portions of the ribbon electrode into the interior space <b>60</b>. Alternatively, the ribbon electrode may be formed to have asymmetrical regions.

p-0121The mesh structure <b>22</b> may also be altered to facilitate blood-mediated cooling of the energy delivery element <b>24</b>. <figref idrefs="DRAWINGS">FIG. 23</figref> illustrates an embodiment in which a mesh structure <b>2322</b> features axially arranged cylindrical sections of different mesh density (e.g., different braid pitch). Sections <b>180</b> that include an energy delivery element may alternate with sections <b>182</b> that do not include an energy delivery element <b>24</b>. The sections <b>180</b> have a more open mesh relative to the sections <b>182</b> that do not include energy delivery elements <b>24</b>. This arrangement may encourage blood flow in and around the more open mesh surrounding the energy delivery elements <b>24</b>. In one embodiment, the alternating sections <b>180</b> and <b>182</b> may be braided as part of a single structure, with varying braid pitch as the mesh structure <b>2322</b> is formed.

p-0122<figref idrefs="DRAWINGS">FIG. 24</figref> illustrates an alternative embodiment including a mesh structure <b>2422</b> having regions <b>184</b> of relatively open mesh surrounding the energy delivery elements <b>24</b> and denser mesh <b>186</b> in the remaining portions of the mesh structure <b>2422</b>. Such a mesh structure <b>2422</b> may be formed by varying braid pitch or by laser cutting the regions <b>184</b> and <b>186</b>. Further, it should be understood that a single mesh structure <b>2422</b> may include 2, 3, or more regions each with a different mesh pitch, as appropriate.

p-0123In certain embodiments, the mesh structure <b>22</b> may be formed of an electrically conductive material. Referring to <figref idrefs="DRAWINGS">FIG. 25</figref>, for example, wire leads <b>190</b> may connect the energy generator <b>26</b> and conductive mesh structure <b>2522</b>. The mesh structure <b>2522</b> forms a contact region <b>192</b> that contacts the renal artery inner wall and acts as the energy delivery element <b>24</b>. Depending on the shape of the mesh structure <b>2522</b>, the contact region <b>192</b> may form a band with a width <b>194</b> that corresponds to the portion of the mesh structure <b>2522</b> that expands to contact the renal artery wall. In this configuration, the mesh structure <b>2522</b> is capable of producing a circumferential lesion. The lesion may be wider for more tube or barrel-shaped mesh structures <b>2522</b> or narrower for more spherical mesh structures <b>2522</b>. Accordingly, depending on the strength of power applied via the energy delivery element <b>24</b> and the particular situation of each patient, the mesh structure <b>2522</b> may be designed so that the contact region is as wide or narrow as desired. In certain embodiments, the contact band has a width <b>194</b> of at least 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, or 10 mm.

p-0124In other embodiments, the electrically conductive mesh structure <b>22</b> is at least partially insulated. For example, the fibers <b>58</b> can be metal wires covered with an electrically insulating material and portions of the insulating material may be stripped away to expose one or more energy delivery elements <b>24</b>. The energy delivery elements <b>24</b> may be any size, shape, or number, and may be positioned relative to one another as provided herein. For example, one or more circumferential bands may be created along the length of the mesh structure <b>22</b>. The bands may be formed of a desired width by removing a desired amount of insulating material from the mesh structure <b>22</b>. Alternatively, individual sectors or quadrants (on the external and/or internal portions of the mesh structure <b>22</b>) or selected filaments may have their insulation removed. The insulation can be removed from the fibers <b>58</b> in a variety of ways to create the stripped portions that serve as conductive energy delivery elements <b>24</b>. For example, the insulation may be scraped away or ablated, e.g., by a thermal radiation source such as a laser. Further, the energy delivery elements may be formed by masking selected portions of the mesh structure <b>22</b> that are intended to remain insulated after laser ablation (of the unmasked portions).

p-0125As shown in <figref idrefs="DRAWINGS">FIG. 26</figref>, a mesh structure <b>2622</b> itself may be formed from an insulated electrically conductive material. In such embodiments, any individual energy delivery element <b>24</b> formed by selective removal of insulation to expose the electrically conductive material may be electrically connected to the other energy delivery elements <b>24</b> on the mesh structure <b>2622</b>. Electrically conductive fibers <b>2658</b> of the mesh structure <b>2622</b> may be formed (e.g., braided) so that spaced apart locations on the mesh structure <b>24</b> are electrically connected to one another. In such an arrangement, in order to obtain electrically independent energy delivery elements <b>24</b> (i.e., that may be activated and operated separately) additional mesh structures <b>22</b> may be associated with the treatment device. For example, as shown in <figref idrefs="DRAWINGS">FIG. 27</figref>, mesh structures <b>2722</b><i>a </i>and <b>2722</b><i>b </i>each include respective energy delivery elements <b>24</b><i>a </i>and <b>24</b><i>b</i>. A proximal end <b>42</b><i>a </i>of the mesh structure <b>2722</b><i>a </i>and a distal end <b>44</b><i>b </i>of the mesh structure <b>22</b><i>b </i>may be joined via a joining piece <b>198</b> that electrically insulates the two structures. Energy delivery element <b>24</b><i>a </i>is coupled to a wire lead(s) <b>190</b><i>a</i>, while energy delivery element <b>24</b><i>b </i>is coupled to a separate wire lead(s) <b>190</b>(<i>b</i>). By independently supplying power to wire leads <b>190</b><i>a </i>or <b>190</b><i>b</i>, energy delivery elements <b>24</b><i>a </i>and <b>24</b><i>b </i>may be activated separately. As shown, the mesh structures <b>2722</b><i>a </i>and <b>2722</b><i>b </i>may be used in conjunction with guide wire <b>66</b>. In such an embodiment, the joining piece <b>198</b> may include an internal passage sized to accommodate the guide wire and the distal end <b>44</b><i>a </i>of the mesh structure <b>2722</b><i>a </i>may also feature an opening <b>199</b> that permits passage of the guide wire <b>66</b>.

p-0126The mesh structure <b>22</b> can take on various shapes when expanded to control arterial surface contact and cooling fluid flow around the mesh structure <b>22</b>. <figref idrefs="DRAWINGS">FIG. 28</figref>, for example, illustrates an expanded mesh structure <b>2822</b> having mesh projections <b>2881</b> extending radially from the longitudinal axis of the elongated shaft <b>16</b>. A plurality of mesh projections <b>2881</b> are disposed around the circumference of mesh structure <b>2822</b> and can comprise conical mesh projections terminating in electrodes <b>24</b> and permitting flow of cooling fluid therebetween or can comprise one or more annular rings or other shapes. <figref idrefs="DRAWINGS">FIG. 29</figref> likewise illustrates an expanded mesh structure <b>2922</b> having a plurality of spaced-apart annular mesh ribs <b>2981</b> formed in and protruding outwardly from a generally cylindrical mesh body. Mesh ribs <b>2981</b> can include energy delivery elements <b>24</b> mounted at outermost circumferential points to contact the renal artery wall while still allowing blood or other fluid to flow within and around the mesh structure <b>2922</b>. The shapes of mesh points <b>2881</b> and mesh ribs <b>2981</b> can be heat-set into a generally cylindrical mesh body. In the illustrated embodiments, the mesh structures <b>2822</b>, <b>2922</b> further include distal openings <b>2899</b>, <b>2999</b> that permit passage of the guide wire <b>66</b>.

p-0127Alternatively, electrically isolated energy delivery elements <b>24</b> may be formed on a single mesh structure <b>22</b>. <figref idrefs="DRAWINGS">FIG. 30</figref>, for example, is a partial perspective view of a mesh structure <b>3022</b> formed from sections of insulated electrically conductive material <b>202</b> and <b>204</b> separated by a section <b>200</b> of electrically nonconductive material. Section <b>202</b> and section <b>204</b> are electrically isolated from one another and, therefore, may support respective electrically isolated energy delivery elements <b>24</b>, which may be created by removing any insulating material to create a desired size, shape, and number of energy delivery elements <b>24</b>. The sections <b>200</b>, <b>202</b>, and <b>204</b> may be joined together via adhesion or other suitable techniques.

p-0128Referring to <figref idrefs="DRAWINGS">FIG. 31</figref>, a woven configuration of a mesh structure <b>3122</b> is depicted in which longitudinal fibers <b>206</b> (e.g., running axially along the length of the mesh structure <b>3122</b>) are electrically conductive while the circumferential fibers <b>208</b> are electrically nonconductive. Because of the woven nature of the structure, the longitudinal fibers may be electrically isolated from one another because the circumferential fibers are electrically nonconductive. Alternatively, as shown in <figref idrefs="DRAWINGS">FIG. 32</figref>, a mesh structure <b>3222</b> having the circumferential fibers <b>210</b> may be electrically conductive, while the longitudinal fibers <b>212</b> are electrically nonconductive. In both embodiments, the electrically conductive fibers (e.g., <b>206</b>, <b>210</b>) may be covered with an insulating polymer. Multiple energy delivery elements <b>24</b> that are electrically isolated from one another may be created by stripping away the insulating polymer from the electrically conductive fibers. In a particular embodiment, the insulating polymer coating the electrically conductive fibers may have a lower melt temperature relative to the electrically nonconductive fibers. By applying just enough heat to melt the insulating material from desired locations on the electrically conductive fibers, energy delivery elements <b>24</b> may be created without damaging the integrity of the electrically nonconductive fibers. In particular, energy delivery elements <b>24</b> may be formed in circumferential bands, either by stripping away insulating material from a latitudinal fiber <b>210</b> or by simply weaving uninsulated, electrically conductive fibers into the mesh structure <b>3222</b>.

p-0129D. Applying Energy to Tissue Via the Energy Delivery Element(s)

p-0130Referring back to <figref idrefs="DRAWINGS">FIG. 1</figref>, the energy generator <b>26</b> may supply a continuous or pulsed RF electric field to the energy delivery element <b>24</b>. Although a continuous delivery of RF energy is desirable, the application of RF energy in pulses may allow the application of relatively higher instantaneous power (e.g., higher power), longer or shorter total duration times, and/or better controlled intravascular renal neuromodulation therapy. Pulsed energy may also allow for the use of a smaller energy delivery element <b>24</b>.

p-0131As previously discussed, energy delivery may be controlled and monitored via data collected with one or more sensors, such as temperature sensors (e.g., thermocouples, thermistors, etc.), impedance sensors, pressure sensors, optical sensors, flow sensors, chemical sensors, etc., which may be incorporated into or on the energy delivery element <b>24</b>, the mesh structure <b>22</b>, and/or in/on adjacent areas on the distal portion <b>20</b>. A sensor may be incorporated into the energy delivery element <b>24</b> in a manner that specifies whether the sensor(s) are in contact with tissue at the treatment site and/or are facing blood flow. The ability to specify temperature sensor placement relative to tissue and blood flow is significant since a temperature gradient across the electrode from the side facing blood flow to the side in contact with the vessel wall may be, e.g., up to about 15° C. (for platinum-iridium electrodes). In other embodiments including gold electrodes, this temperature gradient can be around, for example, 1-2° C. In still further embodiments, the temperature gradient can vary based, at least in part, on the electrode configuration/material. Significant gradients across the electrode in other sensed data (e.g., flow, pressure, impedance, etc.) also are expected.

p-0132The sensor(s) may, for example, be incorporated on or near the side of the energy delivery element <b>24</b> that contacts the vessel wall at the treatment site during power and energy delivery or may be incorporated on the opposing side of the energy delivery element <b>24</b> that faces blood flow during energy delivery, and/or may be incorporated within certain regions of the energy delivery element <b>24</b> (e.g., distal, proximal, quadrants, etc.). In some embodiments, multiple sensors may be provided at multiple positions along the energy delivery element <b>24</b> or mesh structure <b>22</b> and/or relative to blood flow. For example, a plurality of circumferentially and/or longitudinally spaced sensors may be provided. In one embodiment, a first sensor may face the vessel wall during treatment, and a second sensor may face blood flow.

p-0133Additionally or alternatively, various microsensors may be used to acquire data corresponding to the energy delivery element <b>24</b>, the vessel wall and/or the blood flowing across the energy delivery element <b>24</b>. For example, arrays of micro thermocouples and/or impedance sensors may be implemented to acquire data along the energy delivery element <b>24</b> or other parts of the treatment device. Sensor data may be acquired or monitored prior to, simultaneous with, or after the delivery of energy or in between pulses of energy, when applicable. The monitored data may be used in a feedback loop to better control therapy, e.g., to determine whether to continue or stop treatment, and it may facilitate controlled delivery of an increased or reduced power or a longer or shorter duration therapy.

p-0134E. Blood Flow Around the Energy Delivery Element(s)

p-0135Non-target tissue may be protected by blood flow within the respective renal artery that serves as a conductive and/or convective heat sink that carries away excess thermal energy. For example, since blood flow is not blocked by the elongated shaft <b>16</b>, the mesh structure <b>22</b>, and the energy delivery element <b>24</b> it carries, the native circulation of blood in the respective renal artery serves to remove excess thermal energy from the non-target tissue and the energy delivery element. The removal of excess thermal energy by blood flow may also allow for treatments of higher power at lower surface temperatures, where more power may be delivered to the target tissue as thermal energy is carried away from the electrode and non-target tissue. In this way, intravascularly-delivered thermal energy heats target neural fibers located proximate to the vessel wall to modulate the target neural fibers, while blood flow within the respective renal artery protects non-target tissue of the vessel wall from excessive or undesirable thermal injury.

p-0136It may also be desirable to provide enhanced cooling by inducing additional native blood flow across the energy delivery element <b>24</b>. For example, techniques and/or technologies may be implemented by the clinician to increase perfusion through the renal artery or to the energy delivery element <b>24</b> itself. These techniques include positioning partial occlusion elements (e.g., balloons) within upstream vascular bodies such as the aorta, or within a portion of the renal artery to improve flow across the energy delivery element.

p-0137<figref idrefs="DRAWINGS">FIG. 33</figref>, for example, illustrates hypothetical blood flow in a renal artery. Blood flow (F) is thought to be laminar, i.e., exhibit a gradient of flow velocities. In an area closest to the center of the artery, e.g., area <b>214</b>, the blood flow velocity F may be faster relative to areas closer to the renal artery wall <b>55</b>, e.g., areas <b>215</b>. Accordingly, the blood flow F nearest the location of the energy delivery element <b>24</b> is relatively slow. Because cooling of the energy delivery element <b>24</b> is mediated by blood flow, improved cooling may be achieved by redirecting the blood flow F in the renal artery so that the blood flowing around the energy delivery element <b>24</b> is relatively faster.

p-0138<figref idrefs="DRAWINGS">FIG. 34</figref> illustrates an embodiment in which a fluid redirecting element <b>220</b> is positioned approximately within the center of the renal artery. Accordingly, the flowing blood, represented by arrows <b>216</b>, including faster flowing blood, is redirected towards the energy delivery element <b>24</b>. The fluid redirecting element may be any biocompatible material, such as PET, that is positioned to encourage blood flow towards the energy delivery element <b>24</b> on a mesh structure <b>3422</b>.

p-0139As shown in <figref idrefs="DRAWINGS">FIG. 35</figref>, the fluid redirecting element <b>220</b> may extend from the distal end region <b>20</b> of the elongated shaft <b>16</b>, generally along the axis <b>222</b> of the elongated shaft <b>16</b>. For embodiments in which the guide wire <b>66</b> is used, the fluid redirecting element <b>220</b> may include an integral passage <b>224</b> sized and shaped to accommodate the guide wire <b>66</b>. In addition, in some embodiments, the axial length <b>226</b> of the fluid redirecting element <b>220</b> may be at least 25%, at least 50%, or at least 75% of the axial length <b>80</b> of the mesh structure <b>3422</b> in the expanded configuration. In any case, in order to maximize redirected blood flow, the fluid redirecting element <b>220</b> may extend at least far enough into the mesh structure <b>3422</b> so that an imaginary axis <b>230</b> through the energy delivery element <b>24</b> (e.g., <b>24</b><i>a </i>or <b>24</b><i>b</i>) and orthogonal to the axis <b>222</b> intersects the fluid redirecting element <b>220</b>. The diameter <b>228</b> of the fluid redirecting element <b>220</b> may be expandable such that in its unexpanded state it is generally compatible with insertion, repositioning, and removal of the mesh structure <b>3422</b> and in its expanded state it is configured to redirect blood flow toward areas closer to the renal artery wall, e.g., areas <b>215</b> of <figref idrefs="DRAWINGS">FIG. 33</figref>. As shown in <figref idrefs="DRAWINGS">FIG. 36</figref>, in a collapsed configuration, the mesh structure <b>3422</b> may conform to the shape of the fluid redirecting element <b>220</b>. The diameter <b>228</b> may be slightly larger than, about equal to, or less than the diameter <b>61</b> of the elongated shaft. In one embodiment, the diameter <b>228</b> may be less than about 2 mm.

p-0140As shown in <figref idrefs="DRAWINGS">FIG. 37</figref>, a fluid redirecting element <b>221</b> may include surface features <b>240</b>, e.g., fluid dynamic features, for increasing blood flow past the energy delivery element <b>24</b> on a mesh structure <b>3722</b>. The surface features <b>240</b> may include fins, grooves, channels, or rifling formed on the surface of the fluid redirecting element <b>220</b>.

p-0141<figref idrefs="DRAWINGS">FIG. 38</figref> illustrates an embodiment in which a fluid redirecting element <b>223</b> is formed from a compressible material, such as open-cell foam. Pores <b>242</b> within the fluid redirecting element <b>223</b> allow blood to enter the fluid redirecting element <b>223</b> and facilitate its expansion within the renal artery. However, because the fluid redirecting element <b>223</b> may be compressed to a lower profile, its expandability may not interfere with insertion and/or removal of the treatment device. In this manner, the fluid redirecting element <b>223</b> may be configured to have an expanded diameter that is relatively larger than the diameter <b>61</b> of the elongated shaft. Alternatively, the fluid redirecting element <b>223</b> may take the form of an inflatable balloon, or an expandable mesh, as shown in <figref idrefs="DRAWINGS">FIG. 39</figref>. In <figref idrefs="DRAWINGS">FIG. 39</figref>, a fluid redirecting element <b>225</b> may be formed of a denser mesh relative to the mesh structure <b>3922</b>.

p-0142A fluid redirecting element may also be used in conjunction with an umbrella-type or parachute-type mesh structure <b>22</b>. For example, as illustrated in <figref idrefs="DRAWINGS">FIG. 40</figref>, the proximal end <b>42</b> of the mesh structure <b>4022</b> may be axially separated and coupled to the elongated shaft <b>16</b> via wires <b>262</b>. A fluid redirecting element <b>227</b> (e.g., a solid, foam, or expandable mesh) may be disposed along a wire <b>262</b> to redirect blood flow <b>264</b> towards the energy delivery element <b>24</b>.

p-0143In addition, or as an alternative, to passively utilizing blood flow as a heat sink, active cooling may be provided to remove excess thermal energy and protect non-target tissues. For example, a thermal fluid infusate may be injected, infused, or otherwise delivered into the vessel in an open circuit system. Thermal fluid infusates used for active cooling may, for example, include (room temperature or chilled) saline or some other biocompatible fluid. The thermal fluid infusate(s) may, for example, be introduced through the treatment device <b>12</b> via one or more infusion lumens and/or ports. When introduced into the bloodstream, the thermal fluid infusate(s) may, for example, be introduced through a guide catheter at a location upstream from the energy delivery element <b>24</b> or at other locations relative to the tissue for which protection is sought. In a particular embodiment fluid infusate is injected through a lumen into internal space <b>60</b> so as to flow through interstitial spaces between filaments <b>58</b> and around energy delivery elements <b>24</b>. The delivery of a thermal fluid infusate in the vicinity of the treatment site (via an open circuit system and/or via a closed circuit system) may, for example, allow for the application of increased/higher power treatment, may allow for the maintenance of lower temperature at the vessel wall during energy delivery, may facilitate the creation of deeper or larger lesions, may facilitate a reduction in treatment time, may allow for the use of a smaller electrode size, or a combination thereof.

p-0144Accordingly, the treatment device <b>12</b> may include features for an open circuit cooling system, such as a lumen in fluid communication with a source of infusate and a pumping mechanism (e.g., manual injection or a motorized pump) for injection or infusion of saline or some other biocompatible thermal fluid infusate from outside the patient, through elongated shaft <b>16</b> and towards the energy delivery element <b>24</b> into the patient's bloodstream during energy delivery. In addition, the distal end region <b>20</b> of the elongated shaft <b>16</b> may include one or more ports for injection or infusion of saline directly at the treatment site.

III. USE OF THE SYSTEM

p-0145A. Intravascular Delivery, Deflection and Placement of the Treatment Device

p-0146As mentioned previously, any one of the embodiments of the treatment devices described herein may be delivered using over-the-wire (“OTW”) or rapid exchange (“RX”) techniques. When delivered in this manner, the elongated shaft <b>16</b> includes a passage or lumen accommodating passage of a guide wire. Alternatively, any one of the treatment devices described herein may be deployed using a conventional guide catheter or pre-curved renal guide catheter (e.g., as shown in <figref idrefs="DRAWINGS">FIG. 8</figref>). When using a guide catheter, the femoral artery is exposed and cannulated at the base of the femoral triangle, using conventional techniques. In one approach, a guide wire may be inserted through the access site and passed using image guidance through the femoral artery, into the iliac artery and aorta, and into either the left or right renal artery. A guide catheter may be passed over the guide wire into the accessed renal artery. The guide wire may then be removed. Alternatively, a renal guide catheter, which is specifically shaped and configured to access a renal artery, may be used instead of using a guide wire. Still alternatively, the treatment device may be routed from the femoral artery to the renal artery using angiographic guidance and without the need of a guide catheter.

p-0147When a guide catheter is used, at least three delivery approaches may be implemented. In one approach, one or more of the aforementioned delivery techniques may be used to position a guide catheter within the renal artery just distal to the entrance of the renal artery. The treatment device is then routed via the guide catheter into the renal artery. Once the treatment device is properly positioned within the renal artery, the guide catheter can be retracted from the renal artery into the abdominal aorta. In this approach, the guide catheter should be sized and configured to accommodate passage of the treatment device. For example, a 6 French guide catheter may be used.

p-0148In a second approach, a first guide catheter is placed at the entrance of the renal artery (with or without a guide wire). A second guide catheter (also called a delivery sheath) is passed via the first guide catheter (with or without the assistance of a guide wire) into the renal artery. The treatment device is then routed via the second guide catheter into the renal artery. Once the treatment device is properly positioned within the renal artery the second guide catheter is retracted, leaving the first guide catheter at the entrance to the renal artery. In this approach the first and second guide catheters should be sized and configured to accommodate passage of the second guide catheter within the first guide catheter (i.e., the inner diameter of the first guide catheter should be greater than the outer diameter of the second guide catheter). For example, a 8 French guide catheter may be used for the first guide catheter, and 5 French guide catheter may be used for the second guide catheter.

p-0149In a third approach, a renal guide catheter may be positioned within the abdominal aorta just proximal to the entrance of the renal artery. Any one of the treatment devices described herein may be passed through the guide catheter and into the accessed renal artery. The elongated shaft makes atraumatic passage through the guide catheter, in response to forces applied to the elongated shaft <b>16</b> through the handle assembly <b>34</b>.

p-0150B. Control of Applied Energy

p-0151With the treatments disclosed herein for delivering therapy to target tissue, it may be beneficial for energy to be delivered to the target neural structures in a controlled manner. The controlled delivery of energy will allow the zone of thermal treatment to extend into the renal fascia while reducing undesirable energy delivery or thermal effects to the vessel wall. A controlled delivery of energy may also result in a more consistent, predictable and efficient overall treatment. Accordingly, as noted previously, the energy generator <b>26</b> can include a processor-based control including a memory with instructions for executing an algorithm <b>30</b> (see <figref idrefs="DRAWINGS">FIG. 1</figref>) for controlling the delivery of power and energy to the energy delivery device <b>24</b>. The algorithm <b>30</b>, a representative embodiment of which is shown in <figref idrefs="DRAWINGS">FIG. 41</figref>, may be implemented as a conventional computer program for execution by a processor coupled to the energy generator <b>26</b>. A clinician using step-by-step instructions may also implement the algorithm <b>30</b> manually.

p-0152The operating parameters monitored in accordance with the algorithm may include, for example, temperature, time, impedance, power, flow velocity, volumetric flow rate, blood pressure, heart rate, etc. Discrete values in temperature may be used to trigger changes in power or energy delivery. For example, high values in temperature (e.g., 85° C.) could indicate increased risk of thrombosis, etc., in which case the algorithm may decrease or stop the power and energy delivery to prevent undesirable thermal effects to target or non-target tissue. Time additionally or alternatively may be used to prevent undesirable thermal alteration to non-target tissue. For each treatment, a set time (e.g., 2 minutes) is checked to prevent indefinite delivery of power.

p-0153Impedance may be used to measure tissue changes. Impedance indicates the electrical property of the treatment site. In thermal inductive embodiments, when electric field is applied to the treatment site, the impedance will decrease as the tissue become less resistive to current flow. If too much energy is applied, tissue desiccation or coagulation may occur near the electrode. When tissue at the treatment site becomes desiccated or decreases in water content, it becomes less electrically conductive, resulting in an overall increase in sensed impedance. When high impedance coagulum forms on the surface of an electrode, the covered area becomes insulated to some degree and active surface area is effectively decreased. Impedance is inversely proportional to electrode surface area. Therefore, insulating part of the electrode and decreasing active surface area can result in an increase in impedance. An increase in tissue impedance may be indicative or predictive of undesirable thermal alteration to target or non-target tissue. In other embodiments, the impedance value may be used to assess contact of the energy delivery element <b>24</b> with the tissue. For a single electrode configuration, a relatively high, stable impedance value may be indicative of good contact. For a multiple electrode configurations, relatively high, stable impedance values on both electrodes and a relatively small and stable difference in impedance values may be indicative of good contact with the tissue. Accordingly, impedance information may be provided to a downstream monitor, which in turn may provide an indication to a clinician related to the quality of the energy delivery element <b>24</b> contact with the tissue. Additionally or alternatively, power is an effective parameter to monitor in controlling the delivery of therapy. Power is a function of voltage and current. The algorithm may tailor the voltage and/or current to achieve a desired power.

p-0154Derivatives of the aforementioned parameters (e.g., rates of change) also may be used to trigger changes in power or energy delivery. For example, the rate of change in temperature could be monitored such that power output is reduced in the event that a sudden rise in temperature is detected. Likewise, the rate of change of impedance could be monitored such that power output is reduced in the event that a sudden rise in impedance is detected.

p-0155As seen in <figref idrefs="DRAWINGS">FIG. 41</figref>, when a clinician initiates treatment (e.g., via the foot pedal), the control algorithm <b>30</b> includes instructions to the generator <b>26</b> to gradually adjust its power output to a first power level P₁(e.g., 5 watts) over a first time period t₁(e.g., 15 seconds). The power increase during the first time period is generally linear. As a result, the generator <b>26</b> increases its power output at a generally constant rate of P₁/t₁. Alternatively, the power increase may be non-linear (e.g., exponential or parabolic) with a variable rate of increase. Once P₁and t₁are achieved, the algorithm may hold at P₁until a new time t₂for a predetermined period of time t₂−t₁(e.g., 3 seconds). At t₂power is increased by a predetermined increment (e.g., 1 watt) to P₂over a predetermined period of time, t₃−t₂(e.g., 1 second). This power ramp in predetermined increments of about 1 watt over predetermined periods of time may continue until a maximum power P_MAXis achieved or some other condition is satisfied. In one embodiment, P_MAXis 8 watts. In another embodiment P_MAXis 10 watts. Optionally, the power may be maintained at the maximum power P_MAXfor a desired period of time or up to the desired total treatment time (e.g., up to about 120 seconds).

p-0156In <figref idrefs="DRAWINGS">FIG. 41</figref>, algorithm <b>30</b> illustratively includes a power-control algorithm. However, it should be understood that algorithm <b>30</b> alternatively may include a temperature-control algorithm. For example, power may be gradually increased until a desired temperature (or temperatures) is obtained for a desired duration (durations). In another embodiment, a combination power-control and temperature-control algorithm may be provided. In still further embodiments, the algorithm <b>30</b> may include additional features and/or have different parameters.

p-0157As discussed, the algorithm <b>30</b> includes monitoring certain operating parameters (e.g., temperature, time, impedance, power, flow velocity, volumetric flow rate, blood pressure, heart rate, etc.). The operating parameters may be monitored continuously or periodically. The algorithm <b>30</b> checks the monitored parameters against predetermined parameter profiles to determine whether the parameters individually or in combination fall within the ranges set by the predetermined parameter profiles. If the monitored parameters fall within the ranges set by the predetermined parameter profiles, then treatment may continue at the commanded power output. If monitored parameters fall outside the ranges set by the predetermined parameter profiles, the algorithm <b>30</b> adjusts the commanded power output accordingly. For example, if a target temperature (e.g., 65° C.) is achieved, then power delivery is kept constant until the total treatment time (e.g., 120 seconds) has expired. If a first temperature threshold (e.g., 70° C.) is achieved or exceeded, then power is reduced in predetermined increments (e.g., 0.5 watts, 1.0 watts, etc.) until a target temperature is achieved. If a second power threshold (e.g., 85° C.) is achieved or exceeded, thereby indicating an undesirable condition, then power delivery may be terminated. The system may be equipped with various audible and visual alarms to alert the operator of certain conditions.

p-0158The following is a non-exhaustive list of events under which algorithm <b>30</b> may adjust and/or terminate/discontinue the commanded power output: <ul><li id="ul0001-0001" num="0000"><ul><li id="ul0002-0001" num="0155">(1) The measured temperature exceeds a maximum temperature threshold (e.g., about 70 to about 85° C.).</li><li id="ul0002-0002" num="0156">(2) The average temperature derived from the measured temperature exceeds an average temperature threshold (e.g., about 65° C.).</li><li id="ul0002-0003" num="0157">(3) The rate of change of the measured temperature exceeds a rate of change threshold.</li><li id="ul0002-0004" num="0158">(4) The temperature rise over a period of time is below a minimum temperature change threshold while the generator <b>26</b> has non-zero output. Poor contact between the energy delivery element <b>24</b> and the arterial wall may cause such a condition.</li><li id="ul0002-0005" num="0159">(5) A measured impedance exceeds an impedance threshold (e.g., <20 Ohms, or >500 Ohms).</li><li id="ul0002-0006" num="0160">(6) A measured impedance exceeds a relative threshold (e.g., impedance decreases from a starting or baseline value and then rises above this baseline value)</li><li id="ul0002-0007" num="0161">(7) A measured power exceeds a power threshold (e.g., >8 Watts or >10 Watts).</li><li id="ul0002-0008" num="0162">(8) A measured duration of power delivery exceeds a time threshold (e.g., >120 seconds).</li></ul></li></ul>

p-0159It should be understood that the foregoing list of parameters are merely provided as examples. In other embodiments, the algorithm <b>30</b> may include a variety of different parameters. For example, different electrode designs/configurations can result in changes to the operating parameters.

p-0160Advantageously, the magnitude of maximum power delivered during renal neuromodulation treatment in accordance with the present technology may be relatively low (e.g., less than about 15 Watts, for example, less than about 10 Watts or less than about 8 Watts) as compared, for example, to the power levels utilized in electrophysiology treatments to achieve cardiac tissue ablation (e.g., power levels greater than about 15 Watts, for example, greater than about 30 Watts). Since relatively low power levels may be utilized to achieve such renal neuromodulation, the flow rate and/or total volume of intravascular infusate injection needed to maintain the energy delivery element and/or non-target tissue at or below a desired temperature during power delivery (e.g., at or below about 50° C., for example, at or below about 45° C.) also may be relatively lower than would be required at the higher power levels used, for example, in electrophysiology treatments (e.g., power levels above about 15 Watts). In embodiments in which active cooling is used, the relative reduction in flow rate and/or total volume of intravascular infusate infusion advantageously may facilitate the use of intravascular infusate in higher risk patient groups that would be contraindicated were higher power levels and, thus, correspondingly higher infusate rates/volumes utilized (e.g., patients with heart disease, heart failure, renal insufficiency and/or diabetes mellitus).

p-0161In embodiments comprising relatively large energy delivery elements <b>24</b> (e.g., such as the embodiment shown in <figref idrefs="DRAWINGS">FIG. 25</figref> in which the mesh structure is electrically conductive and all or a large portion of the mesh structure is uninsulated) larger magnitudes of power may be delivered during renal neuromodulation treatment in accordance with the present technology. For example, power levels of about 30 W to 40 W may be sufficient with relatively large energy delivery elements that may spread the power over a large area.

IV. PREPACKAGED KIT FOR DISTRIBUTION, TRANSPORT AND SALE OF THE DISCLOSED APPARATUSES AND SYSTEMS

p-0162As shown in <figref idrefs="DRAWINGS">FIG. 42</figref>, one or more components of the system <b>10</b> shown in <figref idrefs="DRAWINGS">FIG. 1</figref> may be packaged together in a kit <b>276</b> for convenient delivery to and use by the customer/clinical operator. Components suitable for packaging include, the treatment device <b>12</b>, the cable <b>28</b> for connecting the treatment device <b>12</b> to the energy generator <b>26</b>, the neutral or dispersive electrode <b>38</b>, and/or one or more guide catheters (e.g., a renal guide catheter). Cable <b>28</b> may also be integrated into the treatment device <b>12</b> such that both components are packaged together. Each component may have its own sterile packaging (for components requiring sterilization) or the components may have dedicated sterilized compartments within the kit packaging. This kit may also include step-by-step instructions <b>280</b> for use that provide the operator with technical product features and operating instructions for using the system <b>10</b> and treatment device <b>12</b>, including all methods of insertion, delivery, placement, and use of the treatment device <b>12</b> disclosed herein.

V. ADDITIONAL CLINICAL USES OF THE DISCLOSED TECHNOLOGY

p-0163Although certain embodiments of the present techniques relate to at least partially denervating a kidney of a patient to block afferent and/or efferent neural communication from within a renal blood vessel (e.g., renal artery), the apparatuses, methods and systems described herein may also be used for other intravascular treatments. For example, the aforementioned catheter system, or select aspects of such system, may be placed in other peripheral blood vessels to deliver energy and/or electric fields to achieve a neuromodulatory affect by altering nerves proximate to these other peripheral blood vessels. There are a number of arterial vessels arising from the aorta which travel alongside a rich collection of nerves to target organs. Utilizing the arteries to access and modulate these nerves may have clear therapeutic potential in a number of disease states. Some examples include the nerves encircling the celiac trunk, superior mesenteric artery, and inferior mesenteric artery.

p-0164Sympathetic nerves proximate to or encircling the arterial blood vessel known as the celiac trunk may pass through the celiac ganglion and follow branches of the celiac trunk to innervate the stomach, small intestine, abdominal blood vessels, liver, bile ducts, gallbladder, pancreas, adrenal glands, and kidneys. Modulating these nerves in whole (or in part via selective modulation) may enable treatment of conditions including, but not limited to, diabetes, pancreatitis, obesity, hypertension, obesity related hypertension, hepatitis, hepatorenal syndrome, gastric ulcers, gastric motility disorders, irritable bowel syndrome, and autoimmune disorders such as Crohn's disease.

p-0165Sympathetic nerves proximate to or encircling the arterial blood vessel known as the inferior mesenteric artery may pass through the inferior mesenteric ganglion and follow branches of the inferior mesenteric artery to innervate the colon, rectum, bladder, sex organs, and external genitalia. Modulating these nerves in whole (or in part via selective modulation) may enable treatment of conditions including, but not limited to, GI motility disorders, colitis, urinary retention, hyperactive bladder, incontinence, infertility, polycystic ovarian syndrome, premature ejaculation, erectile dysfunction, dyspareunia, and vaginismus.

p-0166While arterial access and treatments received have been provided herein, the disclosed apparatuses, methods and systems may also be used to deliver treatment from within a peripheral vein or lymphatic vessel.

VI. ADDITIONAL DISCUSSION OF PERTINENT ANATOMY AND PHYSIOLOGY

p-0167The following discussion provides further details regarding pertinent patient anatomy and physiology. This section is intended to supplement and expand upon the previous discussion regarding the relevant anatomy and physiology, and to provide additional context regarding the disclosed technology and the therapeutic benefits associated with renal denervation. For example, as mentioned previously, several properties of the renal vasculature may inform the design of treatment devices and associated methods for achieving renal neuromodulation via intravascular access, and impose specific design requirements for such devices. Specific design requirements may include accessing the renal artery, facilitating stable contact between the energy delivery element(s) of such devices and a luminal surface or wall of the renal artery, and/or effectively modulating the renal nerves with the neuromodulatory apparatus.

p-0168A. The Sympathetic Nervous System

p-0169The Sympathetic Nervous System (SNS) is a branch of the autonomic nervous system along with the enteric nervous system and parasympathetic nervous system. It is always active at a basal level (called sympathetic tone) and becomes more active during times of stress. Like other parts of the nervous system, the sympathetic nervous system operates through a series of interconnected neurons. Sympathetic neurons are frequently considered part of the peripheral nervous system (PNS), although many lie within the central nervous system (CNS). Sympathetic neurons of the spinal cord (which is part of the CNS) communicate with peripheral sympathetic neurons via a series of sympathetic ganglia. Within the ganglia, spinal cord sympathetic neurons join peripheral sympathetic neurons through synapses. Spinal cord sympathetic neurons are therefore called presynaptic (or preganglionic) neurons, while peripheral sympathetic neurons are called postsynaptic (or postganglionic) neurons.

p-0170At synapses within the sympathetic ganglia, preganglionic sympathetic neurons release acetylcholine, a chemical messenger that binds and activates nicotinic acetylcholine receptors on postganglionic neurons. In response to this stimulus, postganglionic neurons principally release noradrenaline (norepinephrine). Prolonged activation may elicit the release of adrenaline from the adrenal medulla.

p-0171Once released, norepinephrine and epinephrine bind adrenergic receptors on peripheral tissues. Binding to adrenergic receptors causes a neuronal and hormonal response. The physiologic manifestations include pupil dilation, increased heart rate, occasional vomiting, and increased blood pressure. Increased sweating is also seen due to binding of cholinergic receptors of the sweat glands.

p-0172The sympathetic nervous system is responsible for up- and down-regulating many homeostatic mechanisms in living organisms. Fibers from the SNS innervate tissues in almost every organ system, providing at least some regulatory function to things as diverse as pupil diameter, gut motility, and urinary output. This response is also known as sympatho-adrenal response of the body, as the preganglionic sympathetic fibers that end in the adrenal medulla (but also all other sympathetic fibers) secrete acetylcholine, which activates the secretion of adrenaline (epinephrine) and to a lesser extent noradrenaline (norepinephrine). Therefore, this response that acts primarily on the cardiovascular system is mediated directly via impulses transmitted through the sympathetic nervous system and indirectly via catecholamines secreted from the adrenal medulla.

p-0173Science typically looks at the SNS as an automatic regulation system, that is, one that operates without the intervention of conscious thought. Some evolutionary theorists suggest that the sympathetic nervous system operated in early organisms to maintain survival as the sympathetic nervous system is responsible for priming the body for action. One example of this priming is in the moments before waking, in which sympathetic outflow spontaneously increases in preparation for action.

p-01741. The Sympathetic Chain

p-0175As shown in <figref idrefs="DRAWINGS">FIG. 43</figref>, the SNS provides a network of nerves that allows the brain to communicate with the body. Sympathetic nerves originate inside the vertebral column, toward the middle of the spinal cord in the intermediolateral cell column (or lateral horn), beginning at the first thoracic segment of the spinal cord and are thought to extend to the second or third lumbar segments. Because its cells begin in the thoracic and lumbar regions of the spinal cord, the SNS is said to have a thoracolumbar outflow. Axons of these nerves leave the spinal cord through the anterior rootlet/root. They pass near the spinal (sensory) ganglion, where they enter the anterior rami of the spinal nerves. However, unlike somatic innervation, they quickly separate out through white rami connectors which connect to either the paravertebral (which lie near the vertebral column) or prevertebral (which lie near the aortic bifurcation) ganglia extending alongside the spinal column.

p-0176In order to reach the target organs and glands, the axons should travel long distances in the body, and, to accomplish this, many axons relay their message to a second cell through synaptic transmission. The ends of the axons link across a space, the synapse, to the dendrites of the second cell. The first cell (the presynaptic cell) sends a neurotransmitter across the synaptic cleft where it activates the second cell (the postsynaptic cell). The message is then carried to the final destination.

p-0177In the SNS and other components of the peripheral nervous system, these synapses are made at sites called ganglia. The cell that sends its fiber is called a preganglionic cell, while the cell whose fiber leaves the ganglion is called a postganglionic cell. As mentioned previously, the preganglionic cells of the SNS are located between the first thoracic (T1) segment and third lumbar (L3) segments of the spinal cord. Postganglionic cells have their cell bodies in the ganglia and send their axons to target organs or glands.

p-0178The ganglia include not just the sympathetic trunks but also the cervical ganglia (superior, middle and inferior), which sends sympathetic nerve fibers to the head and thorax organs, and the celiac and mesenteric ganglia (which send sympathetic fibers to the gut).

p-01792. Innervation of the Kidneys

p-0180As <figref idrefs="DRAWINGS">FIG. 44</figref> shows, the kidney is innervated by the renal plexus RP, which is intimately associated with the renal artery. The renal plexus RP is an autonomic plexus that surrounds the renal artery and is embedded within the adventitia of the renal artery. The renal plexus RP extends along the renal artery until it arrives at the substance of the kidney. Fibers contributing to the renal plexus RP arise from the celiac ganglion, the superior mesenteric ganglion, the aorticorenal ganglion and the aortic plexus. The renal plexus RP, also referred to as the renal nerve, is predominantly comprised of sympathetic components. There is no (or at least very minimal) parasympathetic innervation of the kidney.

p-0181Preganglionic neuronal cell bodies are located in the intermediolateral cell column of the spinal cord. Preganglionic axons pass through the paravertebral ganglia (they do not synapse) to become the lesser splanchnic nerve, the least splanchnic nerve, first lumbar splanchnic nerve, second lumbar splanchnic nerve, and travel to the celiac ganglion, the superior mesenteric ganglion, and the aorticorenal ganglion. Postganglionic neuronal cell bodies exit the celiac ganglion, the superior mesenteric ganglion, and the aorticorenal ganglion to the renal plexus RP and are distributed to the renal vasculature.

p-01823. Renal Sympathetic Neural Activity

p-0183Messages travel through the SNS in a bidirectional flow. Efferent messages may trigger changes in different parts of the body simultaneously. For example, the sympathetic nervous system may accelerate heart rate; widen bronchial passages; decrease motility (movement) of the large intestine; constrict blood vessels; increase peristalsis in the esophagus; cause pupil dilation, piloerection (goose bumps) and perspiration (sweating); and raise blood pressure. Afferent messages carry signals from various organs and sensory receptors in the body to other organs and, particularly, the brain.

p-0184Hypertension, heart failure and chronic kidney disease are a few of many disease states that result from chronic activation of the SNS, especially the renal sympathetic nervous system. Chronic activation of the SNS is a maladaptive response that drives the progression of these disease states. Pharmaceutical management of the renin-angiotensin-aldosterone system (RAAS) has been a longstanding, but somewhat ineffective, approach for reducing over-activity of the SNS.

p-0185As mentioned above, the renal sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload (such as heart failure), and progressive renal disease, both experimentally and in humans. Studies employing radiotracer dilution methodology to measure overflow of norepinephrine from the kidneys to plasma revealed increased renal norepinephrine (NE) spillover rates in patients with essential hypertension, particularly so in young hypertensive subjects, which in concert with increased NE spillover from the heart, is consistent with the hemodynamic profile typically seen in early hypertension and characterized by an increased heart rate, cardiac output, and renovascular resistance. It is now known that essential hypertension is commonly neurogenic, often accompanied by pronounced sympathetic nervous system overactivity.

p-0186Activation of cardiorenal sympathetic nerve activity is even more pronounced in heart failure, as demonstrated by an exaggerated increase of NE overflow from the heart and the kidneys to plasma in this patient group. In line with this notion is the recent demonstration of a strong negative predictive value of renal sympathetic activation on all-cause mortality and heart transplantation in patients with congestive heart failure, which is independent of overall sympathetic activity, glomerular filtration rate, and left ventricular ejection fraction. These findings support the notion that treatment regimens that are designed to reduce renal sympathetic stimulation have the potential to improve survival in patients with heart failure.

p-0187Both chronic and end stage renal disease are characterized by heightened sympathetic nervous activation. In patients with end stage renal disease, plasma levels of norepinephrine above the median have been demonstrated to be predictive for both all-cause death and death from cardiovascular disease. This is also true for patients suffering from diabetic or contrast nephropathy. There is compelling evidence suggesting that sensory afferent signals originating from the diseased kidneys are major contributors to initiating and sustaining elevated central sympathetic outflow in this patient group; this facilitates the occurrence of the well known adverse consequences of chronic sympathetic over activity, such as hypertension, left ventricular hypertrophy, ventricular arrhythmias, sudden cardiac death, insulin resistance, diabetes, and metabolic syndrome.

p-0188(i) Renal Sympathetic Efferent Activity

p-0189Sympathetic nerves to the kidneys terminate in the blood vessels, the juxtaglomerular apparatus and the renal tubules. Stimulation of the renal sympathetic nerves causes increased renin release, increased sodium (Na+) reabsorption, and a reduction of renal blood flow. These components of the neural regulation of renal function are considerably stimulated in disease states characterized by heightened sympathetic tone and clearly contribute to the rise in blood pressure in hypertensive patients. The reduction of renal blood flow and glomerular filtration rate as a result of renal sympathetic efferent stimulation is likely a cornerstone of the loss of renal function in cardio-renal syndrome, which is renal dysfunction as a progressive complication of chronic heart failure, with a clinical course that typically fluctuates with the patient's clinical status and treatment. Pharmacologic strategies to thwart the consequences of renal efferent sympathetic stimulation include centrally acting sympatholytic drugs, beta blockers (intended to reduce renin release), angiotensin converting enzyme inhibitors and receptor blockers (intended to block the action of angiotensin II and aldosterone activation consequent to renin release) and diuretics (intended to counter the renal sympathetic mediated sodium and water retention). However, the current pharmacologic strategies have significant limitations including limited efficacy, compliance issues, side effects and others.

p-0190(ii) Renal Sensory Afferent Nerve Activity

p-0191The kidneys communicate with integral structures in the central nervous system via renal sensory afferent nerves. Several forms of “renal injury” may induce activation of sensory afferent signals. For example, renal ischemia, reduction in stroke volume or renal blood flow, or an abundance of adenosine enzyme may trigger activation of afferent neural communication. As shown in <figref idrefs="DRAWINGS">FIGS. 45A and 45B</figref>, this afferent communication might be from the kidney to the brain or might be from one kidney to the other kidney (via the central nervous system). These afferent signals are centrally integrated and may result in increased sympathetic outflow. This sympathetic drive is directed towards the kidneys, thereby activating the RAAS and inducing increased renin secretion, sodium retention, volume retention and vasoconstriction. Central sympathetic over activity also impacts other organs and bodily structures innervated by sympathetic nerves such as the heart and the peripheral vasculature, resulting in the described adverse effects of sympathetic activation, several aspects of which also contribute to the rise in blood pressure.

p-0192The physiology therefore suggests that (i) modulation of tissue with efferent sympathetic nerves will reduce inappropriate renin release, salt retention, and reduction of renal blood flow, and that (ii) modulation of tissue with afferent sensory nerves will reduce the systemic contribution to hypertension and other disease states associated with increased central sympathetic tone through its direct effect on the posterior hypothalamus as well as the contralateral kidney. In addition to the central hypotensive effects of afferent renal denervation, a desirable reduction of central sympathetic outflow to various other sympathetically innervated organs such as the heart and the vasculature is anticipated.

p-0193B. Additional Clinical Benefits of Renal Denervation

p-0194As provided above, renal denervation is likely to be valuable in the treatment of several clinical conditions characterized by increased overall and particularly renal sympathetic activity such as hypertension, metabolic syndrome, insulin resistance, diabetes, left ventricular hypertrophy, chronic end stage renal disease, inappropriate fluid retention in heart failure, cardio-renal syndrome, and sudden death. Since the reduction of afferent neural signals contributes to the systemic reduction of sympathetic tone/drive, renal denervation might also be useful in treating other conditions associated with systemic sympathetic hyperactivity. Accordingly, renal denervation may also benefit other organs and bodily structures innervated by sympathetic nerves, including those identified in <figref idrefs="DRAWINGS">FIG. 43</figref>. For example, as previously discussed, a reduction in central sympathetic drive may reduce the insulin resistance that afflicts people with metabolic syndrome and Type II diabetics. Additionally, patients with osteoporosis are also sympathetically activated and might also benefit from the down regulation of sympathetic drive that accompanies renal denervation.

p-0195C. Achieving Intravascular Access to the Renal Artery

p-0196In accordance with the present technology, neuromodulation of a left and/or right renal plexus RP, which is intimately associated with a left and/or right renal artery, may be achieved through intravascular access. As <figref idrefs="DRAWINGS">FIG. 46A</figref> shows, blood moved by contractions of the heart is conveyed from the left ventricle of the heart by the aorta. The aorta descends through the thorax and branches into the left and right renal arteries. Below the renal arteries, the aorta bifurcates at the left and right iliac arteries. The left and right iliac arteries descend, respectively, through the left and right legs and join the left and right femoral arteries.

p-0197As <figref idrefs="DRAWINGS">FIG. 46B</figref> shows, the blood collects in veins and returns to the heart, through the femoral veins into the iliac veins and into the inferior vena cava. The inferior vena cava branches into the left and right renal veins. Above the renal veins, the inferior vena cava ascends to convey blood into the right atrium of the heart. From the right atrium, the blood is pumped through the right ventricle into the lungs, where it is oxygenated. From the lungs, the oxygenated blood is conveyed into the left atrium. From the left atrium, the oxygenated blood is conveyed by the left ventricle back to the aorta.

p-0198As will be described in greater detail later, the femoral artery may be accessed and cannulated at the base of the femoral triangle just inferior to the midpoint of the inguinal ligament. A catheter may be inserted percutaneously into the femoral artery through this access site, passed through the iliac artery and aorta, and placed into either the left or right renal artery. This comprises an intravascular path that offers minimally invasive access to a respective renal artery and/or other renal blood vessels.

p-0199The wrist, upper arm, and shoulder region provide other locations for introduction of catheters into the arterial system. For example, catheterization of either the radial, brachial, or axillary artery may be utilized in select cases. Catheters introduced via these access points may be passed through the subclavian artery on the left side (or via the subclavian and brachiocephalic arteries on the right side), through the aortic arch, down the descending aorta and into the renal arteries using standard angiographic technique.

p-0200D. Properties and Characteristics of the Renal Vasculature

p-0201Since neuromodulation of a left and/or right renal plexus RP may be achieved in accordance with the present technology through intravascular access, properties and characteristics of the renal vasculature may impose constraints upon and/or inform the design of apparatus, systems, and methods for achieving such renal neuromodulation. Some of these properties and characteristics may vary across the patient population and/or within a specific patient across time, as well as in response to disease states, such as hypertension, chronic kidney disease, vascular disease, end-stage renal disease, insulin resistance, diabetes, metabolic syndrome, etc. These properties and characteristics, as explained herein, may have bearing on the efficacy of the procedure and the specific design of the intravascular device. Properties of interest may include, for example, material/mechanical, spatial, fluid dynamic/hemodynamic and/or thermodynamic properties.

p-0202As discussed previously, a catheter may be advanced percutaneously into either the left or right renal artery via a minimally invasive intravascular path. However, minimally invasive renal arterial access may be challenging, for example, because as compared to some other arteries that are routinely accessed using catheters, the renal arteries are often extremely tortuous, may be of relatively small diameter, and/or may be of relatively short length. Furthermore, renal arterial atherosclerosis is common in many patients, particularly those with cardiovascular disease. Renal arterial anatomy also may vary significantly from patient to patient, which further complicates minimally invasive access. Significant inter-patient variation may be seen, for example, in relative tortuosity, diameter, length, and/or atherosclerotic plaque burden, as well as in the take-off angle at which a renal artery branches from the aorta. Apparatus, systems and methods for achieving renal neuromodulation via intravascular access should account for these and other aspects of renal arterial anatomy and its variation across the patient population when minimally invasively accessing a renal artery.

p-0203In addition to complicating renal arterial access, specifics of the renal anatomy also complicate establishment of stable contact between neuromodulatory apparatus and a luminal surface or wall of a renal artery. When the neuromodulatory apparatus includes an energy delivery element, such as an electrode, consistent positioning and appropriate contact force applied by the energy delivery element to the vessel wall are important for predictability. However, navigation is impeded by the tight space within a renal artery, as well as tortuosity of the artery. Furthermore, establishing consistent contact is complicated by patient movement, respiration, and/or the cardiac cycle because these factors may cause significant movement of the renal artery relative to the aorta, and the cardiac cycle may transiently distend the renal artery (i.e. cause the wall of the artery to pulse.

p-0204Even after accessing a renal artery and facilitating stable contact between neuromodulatory apparatus and a luminal surface of the artery, nerves in and around the adventia of the artery should be safely modulated via the neuromodulatory apparatus. Effectively applying thermal treatment from within a renal artery is non-trivial given the potential clinical complications associated with such treatment. For example, the intima and media of the renal artery are highly vulnerable to thermal injury. As discussed in greater detail below, the intima-media thickness separating the vessel lumen from its adventitia means that target renal nerves may be multiple millimeters distant from the luminal surface of the artery. Sufficient energy should be delivered to or heat removed from the target renal nerves to modulate the target renal nerves without excessively cooling or heating the vessel wall to the extent that the wall is frozen, desiccated, or otherwise potentially effected to an undesirable extent. A potential clinical complication associated with excessive heating is thrombus formation from coagulating blood flowing through the artery. Given that this thrombus may cause a kidney infarct, thereby causing irreversible damage to the kidney, thermal treatment from within the renal artery should be applied carefully. Accordingly, the complex fluid mechanics and thermodynamic conditions present in the renal artery during treatment, particularly those that may impact heat transfer dynamics at the treatment site, may be important in applying energy (e.g., heating thermal energy) and/or removing heat from the tissue (e.g., cooling thermal conditions) from within the renal artery.

p-0205The neuromodulatory apparatus should also be configured to allow for adjustable positioning and repositioning of the energy delivery element within the renal artery since location of treatment may also impact clinical efficacy. For example, it may be tempting to apply a full circumferential treatment from within the renal artery given that the renal nerves may be spaced circumferentially around a renal artery. In some situations, full-circle lesion likely resulting from a continuous circumferential treatment may be potentially related to renal artery stenosis. Therefore, the formation of more complex lesions along a longitudinal dimension of the renal artery via the mesh structures described herein and/or repositioning of the neuromodulatory apparatus to multiple treatment locations may be desirable. It should be noted, however, that a benefit of creating a circumferential ablation may outweigh the potential of renal artery stenosis or the risk may be mitigated with certain embodiments or in certain patients and creating a circumferential ablation could be a goal. Additionally, variable positioning and repositioning of the neuromodulatory apparatus may prove to be useful in circumstances where the renal artery is particularly tortuous or where there are proximal branch vessels off the renal artery main vessel, making treatment in certain locations challenging. Manipulation of a device in a renal artery should also consider mechanical injury imposed by the device on the renal artery. Motion of a device in an artery, for example by inserting, manipulating, negotiating bends and so forth, may contribute to dissection, perforation, denuding intima, or disrupting the interior elastic lamina.

p-0206Blood flow through a renal artery may be temporarily occluded for a short time with minimal or no complications. However, occlusion for a significant amount of time should be avoided because to prevent injury to the kidney such as ischemia. It could be beneficial to avoid occlusion all together or, if occlusion is beneficial to the embodiment, to limit the duration of occlusion, for example to 2-5 minutes.

p-0207Based on the above described challenges of (1) renal artery intervention, (2) consistent and stable placement of the treatment element against the vessel wall, (3) effective application of treatment across the vessel wall, (4) positioning and potentially repositioning the treatment apparatus to allow for multiple treatment locations, and (5) avoiding or limiting duration of blood flow occlusion, various independent and dependent properties of the renal vasculature that may be of interest include, for example, (a) vessel diameter, vessel length, intima-media thickness, coefficient of friction, and tortuosity; (b) distensibility, stiffness and modulus of elasticity of the vessel wall; (c) peak systolic, end-diastolic blood flow velocity, as well as the mean systolic-diastolic peak blood flow velocity, and mean/max volumetric blood flow rate; (d) specific heat capacity of blood and/or of the vessel wall, thermal conductivity of blood and/or of the vessel wall, and/or thermal convectivity of blood flow past a vessel wall treatment site and/or radiative heat transfer; (e) renal artery motion relative to the aorta induced by respiration, patient movement, and/or blood flow pulsatility: and (f) as well as the take-off angle of a renal artery relative to the aorta. These properties will be discussed in greater detail with respect to the renal arteries. However, dependent on the apparatus, systems and methods utilized to achieve renal neuromodulation, such properties of the renal arteries, also may guide and/or constrain design characteristics.

p-0208As noted above, an apparatus positioned within a renal artery should conform to the geometry of the artery. Renal artery vessel diameter, D_RA, typically is in a range of about 2-10 mm, with most of the patient population having a D_RAof about 4 mm to about 8 mm and an average of about 6 mm. Renal artery vessel length, L_RA, between its ostium at the aorta/renal artery juncture and its distal branchings, generally is in a range of about 5-70 mm, and a significant portion of the patient population is in a range of about 20-50 mm. Since the target renal plexus is embedded within the adventitia of the renal artery, the composite Intima-Media Thickness, IMT, (i.e., the radial outward distance from the artery's luminal surface to the adventitia containing target neural structures) also is notable and generally is in a range of about 0.5-2.5 mm, with an average of about 1.5 mm. Although a certain depth of treatment is important to reach the target neural fibers, the treatment should not be too deep (e.g., >5 mm from inner wall of the renal artery) to avoid non-target tissue and anatomical structures such as the renal vein.

p-0209An additional property of the renal artery that may be of interest is the degree of renal motion relative to the aorta, induced by respiration and/or blood flow pulsatility. A patient's kidney, which located at the distal end of the renal artery, may move as much as 4″ cranially with respiratory excursion. This may impart significant motion to the renal artery connecting the aorta and the kidney, thereby requiring from the neuromodulatory apparatus a unique balance of stiffness and flexibility to maintain contact between the thermal treatment element and the vessel wall during cycles of respiration. Furthermore, the take-off angle between the renal artery and the aorta may vary significantly between patients, and also may vary dynamically within a patient, e.g., due to kidney motion. The take-off angle generally may be in a range of about 30°-135°.

VII. CONCLUSION

p-0210The above detailed descriptions of embodiments of the technology are not intended to be exhaustive or to limit the technology to the precise form disclosed above. Although specific embodiments of, and examples for, the technology are described above for illustrative purposes, various equivalent modifications are possible within the scope of the technology, as those skilled in the relevant art will recognize. For example, while steps are presented in a given order, alternative embodiments may perform steps in a different order. The various embodiments described herein may also be combined to provide further embodiments.

p-0211From the foregoing, it will be appreciated that specific embodiments of the technology have been described herein for purposes of illustration, but well-known structures and functions have not been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments of the technology. Where the context permits, singular or plural terms may also include the plural or singular term, respectively. For example, much of the disclosure herein describes an energy delivery element <b>24</b> (e.g., an electrode) in the singular. It should be understood that this application does not exclude two or more energy delivery elements or electrodes.

p-0212Moreover, unless the word “or” is expressly limited to mean only a single item exclusive from the other items in reference to a list of two or more items, then the use of “or” in such a list is to be interpreted as including (a) any single item in the list, (b) all of the items in the list, or (c) any combination of the items in the list. Additionally, the term “comprising” is used throughout to mean including at least the recited feature(s) such that any greater number of the same feature and/or additional types of other features are not precluded. It will also be appreciated that specific embodiments have been described herein for purposes of illustration, but that various modifications may be made without deviating from the technology. Further, while advantages associated with certain embodiments of the technology have been described in the context of those embodiments, other embodiments may also exhibit such advantages, and not all embodiments need necessarily exhibit such advantages to fall within the scope of the technology. Accordingly, the disclosure and associated technology can encompass other embodiments not expressly shown or described herein.