Device of miniaturised construction for producing high pressure in a fluid to be atomised
Abstract
Abstract: The present invention relates to a miniaturized device for increasing fluid pressure. The tool includes a hollow piston that provides a fluid path and a valve member. The valve member is positioned to move axially so that the valve remains parallel to the piston axis. The valve member is arranged at one end of the hollow piston. The valve member may be arranged partially or completely inside the hollow piston. The tool is particularly adapted for use in a mechanically operated atomizer to produce an inhalable aerosol for liquid medicament without the use of propellant gas.

Term
No projected expiry on record.
- Priority
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39 claims: 39 independent, 0 dependent
- 11 - A device with a miniature structure for compressing a fluid. The device includes a cylindrical hollow piston (17, 22, 28, 31, 33) that is moveable in a cylinder (1) and is equipped with a path through which the fluid passes. The hollow piston contains The cylindrical hollow piston has a widened portion (20, 33) at the inlet or outlet end, and its inner diameter is larger than the inner diameter in the remaining part of the hollow piston. The hollow piston has an edge that is machined internally. (19, 24) at the inlet and outlet ends;High pressure chamber (4) located inside the cylinder in front of the piston;The valve operates without any auxiliary force arising from a spring, and it contains a valve member (18, 23, 29, 37) that has a defined sealing surface at its inlet end. The valve member is directed and installed in a way that allows movement axially within the piston. Hollow piston in its radiating part. The maximum diameter of the valve member is less than the inner diameter of the hollow piston at its expanded part and greater than the inner diameter in the remaining part of the hollow piston. Stop means (19;24;32) are provided at the outlet end of the expanding part of the hollow piston to keep the valve member inside the hollow piston. A valve is closed when the valve member rests on the defined sealing surface, and open when the valve member rests. member on the stop means at the outlet end of the widened part of the hollow piston. 1 - أداة ذات تركيب مصغر لضغط مائع fluid، وتشتمل الأداة على مكبس مجوف اسطواني cylindrical hollow piston (١٧؛ ٢٢؛ ٢٨، ٣١، ٣٣) قابل للحركة في اسطوانة cylinder (١) ومزود بمسار path يمر -المائع fluid خلاله، حيث يحتوي المكبس المجوف الاسطواني cylindrical hollow piston على جزء متسع widened portion (٢٠، ٣٣) عند طرف المدخل أو المخرج، ويكون القطر الداخلي inner diameter له أكبر من القطر الداخلي في الجزء المتبقي من المكبس المجوف hollow piston، ويكون للمكبس المجوف hollow piston حافة edge يتم تشكيلها داخليا (١٩، ٢٤) عند طرفي المدخل والمخرج؛ حجيرة عالية الضغط high pressure chamber (٤) تقع داخل الاسطوانة cylinder أمام المكبس piston؛ وصمام valve يعمل دون أي قوة مساعدة ناشئة عن نابض spring، ويحتوي على عضو صمام valve member (١٨، ٢٣، ٢٩، ٣٧) له سطح محدد مانع للتسرب defined sealing surface عند طرف مدخله ويوجه عضو الصمام valve member ويركب بكيفية تتيح الحركة محوريا داخل المكبس المجوف hollow piston في جزئه المشع. ويكون القطر الأقصى لعضو الصمام valve member أقل من القطر الداخلي للمكبس المجوف hollow piston عند جزئه المتسع وأكبر من القطر الداخلي في الجزء المتبقي من المكبس المجوف hollow piston؛ وتزود وسيلة صد stop means (١٩؛ ٢٤؛ ٣٢) عن طرف مخرج الجزء المتسع من المكبس المجوف hollow piston لإبقاء عضو الصمام valve member داخل المكبس المجوف hollow piston؛ ويكون الصمام valve مغلفا عندما يرتكز عضو الصمام valve member على السطح المحدد لمانع للتسرب defined sealing surface، ويكون مفتوحا عندما يرتكز عضو الصمام valve member على وسيلة الصد stop means عند طرف مخرج الجزء المتسع widened part من المكبس المجوف hollow piston.
- 22 - A device according to protection element 1, where the valve member (18, 23, 29, 37) is symmetrically rotating around a single axis. 2 - أداة وفقا لعنصر الحماية ١ حيث يكون عضو الصمام valve member (١٨، ٢٣، ٢٩، ٣٧) متماثل الدوران حول محور أحادي.
- 33 - A device according to protection element 1 or protection element 2 where the valve member (18, 23, 29, 37) is cylindrical. 3 - أداة وفقا لعنصر الحماية ١ أو عنصر الحماية ٢ حيث يكون عضو الصمام valve member (١٨، ٢٣، ٢٩، ٣٧) اسطوانيا.
- 44 - A device in accordance with any of the foregoing protections wherein at least one recess cavity (21) or indentation (27, 38) is provided in the stop means, or at least one recess cavity (21) or indentation (27, 38) extending radially in the valve member at one end. His way out. 4 - أداة وفقا لأي من عناصر الحماية السابقة حيث يتم تزويد تجويف recess واحد على الأقل في وسيلة الصد stop means، أو تجويف recess واحد على الأقل (٢١) أو تثلم indentation (٢٧، ٣٨) يمتد باتجاه نصف القطر في عضو الصمام valve member عند طرف مخرجه.
- 55 - A device according to any of the previous protection elements, where the cylindrical hollow piston (17, 22, 28) has a widened portion (20) at its outlet end, and the stop means is an internally formed edge (19, 24) At the outlet end of the hollow piston. 5 - أداة وفقا لأي من عناصر الحماية السابقة، حيث يكون للمكبس المجوف الاسطواني cylindrical hollow piston (١٧، ٢٢، ٢٨) جزء مشع widened portion (20) عند طرف مخرجه، و تكون وسيلة الصد stop means عبارة عن حافة edge مشكلة داخليا (١٩، ٢٤) عند طرف مخرج المكبس المجوف hollow piston.
- 66 - A device according to any of Claims 1 to 4, wherein the cylindrical hollow piston (31) has a widened portion (33) at its inlet end, the defined sealing surface is formed as an edge formed internally at At the inlet end of the hollow piston, stop means are provided at the outlet end of the widened portion of the hollow piston. 6 - أداة وفقا لأي من عناصر الحماية من ١ إلى ٤ ، حيث يكون للمكبس المجوف الاسطواني cylindrical hollow piston (٣١) جزء مشع widened portion (٣٣) عند طرف مدخله، يتم تشكيل السطح المحدد المانع للتسرب defined sealing surface في صورة حافة edge مشكلة داخليا عند طرف مدخل المكبر المجوف hollow piston، يتم تزويد وسيلة صد stop means عند طرف مخرج الجزء المتسع widened portion من المكبس المجوف hollow piston.
- 77 - A device according to any of the provisions from 1 to 4, wherein the cylindrical hollow piston (22) has an internally formed edge at one end, and an encircling constriction (25) near the formed edge of the hollow piston, guiding a member The valve member (23) is installed in a way that allows it to move axially inside the hollow piston between the formed edge (24) and the encircling constriction (25). The valve member has a recess cavity (27) in the region of its outlet end. 7 - أداة وفقا لأي من عناصر الحماية من ١ إلى ٤ ، حيث يكون للمكبس المجوف الاسطواني cylindrical hollow piston (٢٢) حافة edge مشكلة داخليا عند أحد طرفيه، و تخصر محيط encircling constriction (٢٥) قرب الحافة edge المشكلة للمكبس المجوف hollow piston، يوجه عضو الصمام valve member (٢٣) ويركب بكيفية تتيح له الحركة محوريا داخل المكبس المجوف hollow piston بين الحافة edge المشكلة (٢٤) والتخصر المحيط encircling constriction (٢٥)، و يكون لعضو الصمام valve member تجويف recess (٢٧) في منطقة طرف مخرجه.
- 88 - A device in accordance with Protection Clause 7, where the cylindrical hollow piston (22;28) has an internally formed edge (24) at its exit as a stop means, and an encircling constriction (25) in the formed edge area. Hollow piston outlet end. 8 - أداة وفقا لعنصر الحماية ٧، حيث يكون للمكبس الاسطواني المجوف cylindrical hollow piston (٢٢؛ ٢٨) حافة edge مشكلة داخليا (٢٤) عند طرف مخرجه بصفتها وسيلة الصد stop means، و تخصر محيط encircling constriction (٢٥) في منطقة الحافة edge المشكلة عد طرف مخرج المكبس المجوف hollow piston.
- 99 - A device in accordance with Claim 7, wherein the cylindrical hollow piston has an internally formed edge at its inlet end as the defined sealing surface, and an encircling constriction is provided adjacent to the edge formed at the inlet end of the hollow piston as stop means. 9 - أداة وفقا لعنصر الحماية ٧، حيث يكون للمكبس المجوف الاسطواني cylindrical hollow piston حافة edge مشكلة داخليا عند طرف مدخله بصفتها السطح المحدد لمانع للتسرب defined sealing surface، و يتم تزويد تخصر محيط encircling constriction بجوار الحافة edge المشكلة عند طرف مدخل المكبس المجوف hollow piston بصفتها وسيلة صد stop means.
- 1010 - A device according to any of the protection elements from 1 to 4, where the cylindrical hollow piston has a first encircling constriction at a distance starting from the exit end of the hollow piston, which acts as a stopping means, and a second encircling constriction between the first constriction and the end. The hollow piston inlet, which acts as a defined sealing surface, guides the valve member and is mounted in such a way that it can rotate axially between the two constrictions. 10 - أداة وفقا لأي من عناصر الحماية من ١ إلى ٤ ، حيث يكون للمكبس المجوف الاسطواني cylindrical hollow piston تخصر محيط encircling constriction أول على بعد يبدأ من طرف مخرج المكبس المجوف hollow piston الذي يعمل كوسيلة صد stop means وتخصر محيط encircling constriction ثان بين التخصر الأول وطرف مدخل المكبس المجوف hollow piston الذي يعمل بمثابة سطح محدد مانع للتسرب defined sealing surface، و يوجه عضو صمام valve member ويركب بكيفية قابلة للدوران محوريا بين التخصرين constrictions.
- 1111 - A device according to protection element 7 or protection element 10, where the inlet end of the hollow piston is provided with a displacement body (26) that has an axially extended channel, and is the aforementioned displacement body. Arranged in the hollow piston and connected to it in a stable connection, preferably adjusted until it reaches the encircling constriction (25) closest to the inlet end of the hollow piston. 11 - أداة وفقا لعنصر الحماية ٧ أو عنصر الحماية 10حيث يزود, طرف مدخل المكبس المجوف hollow piston بجسم إزاحي displacement body (٢٦) له قناة channel ممتدة محوريا، ويكون الجسم الإزاحي displacement body المذكور. مرتب في المكبس المجوف hollow piston ومتصل به اتصالا ثابتا ويفضل أن يعتد حتى يبلغ التخصر المحيط encircling constriction (٢٥) الأقرب إلى طرف مدخل المكبس المجوف hollow piston.
- 1212 - A device according to protection element 7 or protection element 10, where the outlet end of the hollow piston is provided with a displacement body that has an axially extended channel, and the aforementioned displacement body is arranged in the hollow piston and is firmly connected to it, preferably extending until it reaches The encircling constriction closest to the outlet end of the hollow piston. 12 - أداة وفقا لعنصر الحماية ٧ أو عنصر الحماية 10، حيث يزود طرف مخرج المكبس المجوف hollow piston بجسم إزاحي displacement body له قناة channel ممتدة محوريا، ويكون الجسم الإزاحي displacement body المذكور مرتب في المكبس المجوف hollow piston ومتصل به اتصالا ثابتا ويفضل أن يمتد حتى يبلغ التخصر المحيط encircling constriction الأقرب إلى طرف مخرج المكبس المجوف hollow piston.
- 1313 - A device according to any of claims 1 to 4, wherein the cylindrical hollow piston (31) has a widened portion (33) at its inlet end and optionally a tube (32) as a displacement body in the unwidened portion part of the hollow piston, and the widened end of the hollow piston is removed by a closure member (34) with which it is lifted and contains a depressed part (35) that is flat or conical with a bore (36), and directs the valve member (36). 37) It is installed in a way that allows it to move axially in the depressed part, and the aforementioned valve member is optionally removed at the end of its outlet with a slot (38) as a recess or notch. 13 - أداة وفقا لأي من عناصر الحماية من ١ إلى ٤ ، حيث يكون للمكبس المجوف الاسطواني cylindrical hollow piston (٣١) جزء مشع widened portion (٣٣) عند طرف مدخله وبشكل اختياري أنبوبة tube (٣٢) بصفتها جسما إزاحيا displacement body في الجزء غير المتسع unwidened part من المكبس المجوف hollow piston، ويزول الطرف المشع widened end من المكبس المجوف hollow piston بعضو إغلاق closure member (٣٤) ينشل به ويحتوي على جزء منخفض depression (٣٥) مستو أو مخروطي مع فجوة bore (٣٦)، ويوجه عضو الصمام valve member (٣٧) ويركب بكيفية تتيح له الحركة محوريا في الجزء المنخفض depression، ويزول عضو الصمام valve member المذكور اختياريا عند طرف مخرجه بشقب slot (٣٨) بصفته تجويفا recess أو حزا notch.
- 1414 - A device according to any of the previous protection elements where the defined sealing surface is the end surface of the valve member. 14 - أداة وفقا لأي من عناصر الحماية السابقة حيث يكون السطح المحدد لمانع التسرب defined sealing surface عبارة عن السطح الطرفي end surface لعضو الصمام valve member.
- 1515 - An atomizer for atomizing a fluid, consisting of an upper housing part (51), a lower housing part (70), a spring housing, a spring (68), a pump housing (52), and a nozzle. (54), blocking mechanism (62), storage container (71), characterized by the pump housing (52) being mounted in the upper housing part (51) and having a nozzle member at one end provided With nozzle (54);The atomizer includes a tool according to the element The protection comprises a hollow piston (57) with a valve member (58). According to any of protection elements 1 through 11, the drive flange (56) to which the hollow piston is fixed is located in the upper housing part. (51), the blocking or latching mechanism (62) is arranged in the upper housing part, and the spring housing with the spring (68) is located in the lower housing part, which is mounted in a rotatable manner on part The upper housing part is driven by a rotary bearing, and the lower housing part (70) is mounted on the spring housing in the axial direction. 15 - مرذاذ atomizer لتذرية مائع fluid، يتكون من جزء تبييت علوي upper housing part (٥١)، جزء تبييت سفلي lower housing part (٧٠)، مبيت نابض spring housing، نابض spring (٦٨)، مبيت مضخة pump housing (٥٢)، فوهة nozzle (٥٤)، تركيبة سد blocking mechanism (٦٢)، وعاء تخزين storage container (٧١)، يتميز بأن مبيت المضخة pump housing (٥٢) يكون مثبتا في جزء التبييت العلوي upper housing part (51) وله عند أحد طرفيه عضو فوهي nozzle member مزود بفوهة nozzle (٥٤)؛ المرذاذ atomizer يشتمل على أداة وفقا لعنصر الحماية تشتمل على مكبس مجوف hollow piston (٥٧) مع عضو صمام valve member (٥٨) وفقا لأي من عناصر الحماية من ١ إلى ١١، شفة الإدارة drive flange (٥٦) التي يثبت عليها المكبس المجوف hollow piston تقع في جزء التبييت العلوي upper housing part (51)، تركيبة السد أو الإقفال بسقاطة blocking or latching mechanism (٦٢) ترتب في جزء التبييت العلوي upper housing part، مبيت النابض spring housing المزود بالنابض spring (٦٨) يقع في جزء التبييت السفلي lower housing part، الذي يركب بكيفية قابلة للدوران على جزء التبييت العلوي upper housing part عن طريق محمل دوار rotary bearing، جزء التبييت السفلي lower housing part (70) يركب على مبيت النابض spring housing في الاتجاه المحوري.
- 1616 - An atomizer for atomizing a fluid according to protection element 15, where the hollow piston (57) with a valve member (58) according to any of the protection elements from 1 to 1 1 partially protrudes into the cylinder of the pump housing cylinder and is mounted in a removable manner. To rotate axially in the cylinder. 16 - مرذاذ atomizer لتذرية مائع fluid وفقا لعنصر الحماية ١5، حيث المكبس المجوف hollow piston (٥٧) مع عضو الصمام valve member (٥٨) وفقا لأي من عناصر الحماية من ١ إلى ١ ١ يبرز جزئيا في اسطوانة cylinder مبيت المضخة pump housing cylinder ويركب بكيفية قابلة للدوران محوريا في الاسطوانة cylinder.
- 1717 - an atomizer according to protection element 15 or 61, wherein the blocking mechanism is in the form of a helical thrust gear, equipped with a blocking member (62) arranged in an annular fashion with engaging surfaces, a locking button and an actuating button (64). ). 17 - مرذاذ atomizer وفقا لعنصر الحماية 15 أو ٦ ١، حيث تكون تركيبة السد blocking mechanism في صورة مسننة, دفع لولبية helical thrust gear، مزودة بعضو سد blocking member (٦٢) مرتب بشكل حلقي مع سطوح تعشيق engaging وزنق locking وزر تشغيل actuating button (٦٤).
- 1818 - An atomizer according to any of the protection elements from 15 to 17, where a mechanical counter having a spindle (74) and slide (76) is mounted on the spring housing (67) in the outer surface area, and the axis of the said spindle extends parallel to the axis of spring housing. 18 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى 17 ، حيث يركب عناد ميكانيكي mechanical counter له عمود spindle (٧٤) ومزلقة slide (٧٦) على مبيت النابض spring housing (٦٧) في منطقة السطح الخارجي، ويمتد محور العمود spindle المذكور موازيا لمحور مبيت النابض spring housing.
- 1919 - An atomizer in accordance with any of Claims 15 to 18, wherein the nozzle member (54) includes two plates of glass and/or silicon closely connected together, and at least one of the plates has one or more finely structured channels connecting the nozzle inlet. Nozzle at its outlet end. The nozzle outlet end has at least one opening with a diameter not exceeding 10 µm. 19 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى ١٨، حيث يشتمل عضو فوهي nozzle member (٥٤) على لوحين من الزجاج glass و/أو السليكون silicon متصلين معا اتصالا وثقيا، ولأحد اللوحين على الأقل قناة دقيقة البنية واحدة أو أكثر توصل مدخل الفوهة nozzle بطرف مخرجها. ولطرف مخرج الفوهة nozzle فتحة opening واحدة على الأقل قطرها لا يزيد عن 10 ميكرومتر um.
- 2020 - An atomizer according to Protection Tenant 19, where the nozzle member (54) has at least two openings at its outlet end, and the two spraying directions are inclined relative to each other and the two directions meet next to the nozzle openings. 20 - مرذاذ atomizer وفقا لعشر الحماية 19 ، حيث يكون لعضو فوهي nozzle member (54) فتحتان openings على الأقل عند طرف مخرجه، ويكون اتجاها الرش مائلين بالنسبة بعضهما البعض ويلتقى الاتجاهان بجوار فتحات الفوهة nozzle openings.
- 2121 - An atomizer according to any of the protection elements from 15 to 20, where a non-return valve is installed in the pump housing between the nozzle opening and the high pressure chamber of the cylinder. 21 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى 20، حيث يركب صمام لارجعي non-return valve في مبيت المضخة pump housing بين فتحة الفوهة nozzle opening والحجيرة عالية الضغط high pressure chamber للاسطوانة cylinder.
- 2222 - An atomizer according to any of the protection elements from 15 to 21, where the hollow piston (57) exerts a pressure of 5 to 60 megapascals (about 50 to 600 bar) on the fluid from its end opposite the nozzle. That is, at the high-pressure end of the nozzle, at the moment when the button (64) is activated to release the compressed spring (68). 22 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى ٢١، حيث يبذل المكبس المجوف hollow piston (٥٧) ضغطا pressure مقداره يتراوح من 5 إلى 60 ميغاباسكال MPa (من حوالي 50 إلى 600 بار bar) على المائع fluid عن طرفه المقابل للفوهة nozzle، أي، عند طرف الضغط العالي للفوهة nozzle، عند لحظه تشغيل الزر button (٦٤) لإطلاق النابض spring (٦٨) المضغوط.
- 2323 - The atomizer according to protection element 22, where the hollow piston (57) exerts a pressure ranging from 10 to 60 MPa (i.e. from about 100 to 600 bar) on the fluid at its end opposite the nozzle, that is, at the end of The high pressure of the nozzle, when the button (64) is operated to release the compressed spring (68). 23 - مرذاذ atomizer وفقا لعنصر الحماية ٢٢، حيث يبذل المكبس المجوف hollow piston (٥٧) ضغطا pressure يتراوح مقداره من 10 إلى 60 ميغاباسكال MPa (أي من حوالي 100 إلى 600 بار bar) على المائع fluid عند طرفه المقابل للفوهة nozzle، أي، عند طرف الضغط العالي للفوهة nozzle، عند لحظة تشغيل الزر button (٦٤) لإطلاق النابض spring (٦٨) المضغوط.
- 2424 - An atomizer in accordance with any of protections 15 to 23, where a replaceable storage container (71) for the fluid is arranged in the lower housing part (70). 24 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى ٢٣، حيث يرتب وعاء تخزين storage container قابل للاستبدال (٧١) للمائع fluid في جزء التبييت السفلي lower housing part (٧٠).
- 2525 - An atomizer in accordance with any of the protections from 15 to 24, where a storage container (71) is provided for the fluid, and said container contains a pharmaceutical composition. 25 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى 24، حيث يتم تزويد وعاء تخزين storage container (٧١) للمائع fluid، ويحتوي الوعاء container المذكور على تركيب صيدلي pharmaceutical composition.
- 2626 - An atomizer according to any of the protection elements from 15 to 25, where the storage container (71) contains a pharmaceutically acceptable solution of a medicament chosen from the group consisting of Berotec, Berodual, Flunisolide, Atrovent, and Salbutamol. Salbutamol, budesonide, combivent, tlotropium, oxivent, peptides are suitable. 26 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى ٢٥، حيث يحتوي وعاء التخزين storage container (٧١) على محلول مقبول صيدليا pharmaceutically acceptable solution من دواء medicament يختار من المجموعة المكونة من البيروتيك berotec، البيروديوال berodual، الفلونيسوليد ،flunisolide الأتروفنت atrovent، السالبوتامول salbutamol، البوديسونيد budesonide، الكمبفنت combivent، التيوتروبيوم tlotropium، الأكسيفنت oxivent ببتيدات peptides ملائمة.
- 2727 - An atomizer according to any of protection elements 15 to 26 is used to produce medical aerosols without the use of propellant gas. 27 - مرذاذ atomizer وفقا لأي من عناصر الحماية من ١٥ إلى ٢٦ يستخدم لإنتاج إيرروسولات دوائية medical aerosols دون استخدام غاز داسر propellant gas.
- 2828 - An atomizer in accordance with any of the protection elements from 15 to 27 for spraying a liquid at high pressure, including a pump to increase the pressure of a pre-determined volume of liquid and discharge it through an atomizing nozzle. The pump includes a cylinder (52) and a piston (52). 57) Inverted inside, the piston is tubular and the inlet flow path to the cylinder ends after the first end of the piston and is provided with a non-return valve, a liquid reservoir (71) that has a top surface. A membrane, stopper or cap of resilient material that the other end of the piston penetrates to allow flow. Fluid from the reservoir through the length of the piston to the cylinder in the induction stroke, holding the piston and reservoir together when the pump is turned on, and a reciprocating pump means to move the piston and cylinder relative to each other. 28 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى 27 لرش سائل liquid عند ضغط عال يشتمل على مضخة pump لزيادة ضغط حجم محدد مسبقا من سائل liquid وتصريفه عبر فوهة ذرية atomizing nozzle، وتشتمل المضخة pump على اسطوانة cylinder (٥٢)، مكبس piston (٥٧) معكوس داخله، ويكون المكبس piston أنبوبيا ويزول مسار تدفق دخول inlet flow path إلى الاسطوانة cylinder بعد طرف أول first end من المكبس piston ويتم تزويده بصمام لارجعي non-return valve، خزان لسائل liquid reservoir (٧١) له سطح علوي top surface، غشاء membrane، مصد stopper أو غطاء cap من مادة رجوعية resilient material يخترقها الطرف end الآخر من المكبس piston للسماح بتدفق. المائع من الخزان reservoir عبر طول المكبس piston إلى الاسطوانة cylinder في شوط السحب induction stroke، ويثبت المكبس piston والخزان reservoir ببعضهما البعض عند تشغيل المضخة pump، ووسيلة ضخ ترددية pump reciprocating means لتحريك المكبس piston والاسطوانة cylinder بالنسبة لبعضهما البعض.
- 2929 - An atomizer according to protection element 28, wherein the second end of the piston is engaged in order to penetrate the resilient top surface of the reservoir, membrane, stopper or reservoir cap for the first time. 29 - مرذاذ atomizer وفقا لعنصر الحماية ٢٨، حيث يسن الطرف الثاني second end من المكبس piston من أجل اختراق السطح العلوي الرجوعي resilient top surface للخزان reservoir، أو غشاء membrane، مصد stopper أو غطاء cap الخزان reservoir لأول مرة.
- 3030 - An atomizer in accordance with Protection Clause 29, where the pump reciprocating means includes a spring-loaded flange (56) or other member located on the piston, such that the spring (68) operates the pump in the compression direction, A means of tightening the spring when the pump is operating in the induction direction. 30 - مرذاذ atomizer وفقا لعنصر الحماية ٢٩، حيث ذشتمل وسيلة الضخ الترددية pump reciprocating means على شفة تحمل نابض spring-loaded flange (٥٦) أو عضو أخر موجود على المكبس piston، بحيث يشغل النابض spring (٦٨) المضخة pump في اتجاه الانضغاط compression direction، ووسيلة لشد النابض spring عندما تعمل المضخة pump في شوط السحب induction direction.
- 3131 - An atomizer according to Protection Clause 30, wherein the means used to tension the spring (68) includes a helical saw tooth cam operated by rotating one part (51) of the atomizer relative to the other part (70). 31 - مرذاذ atomizer وفقا لعنصر الحماية ٣٠، حيث تشتمل الوسيلة المستخدمة لشد النابض spring (٦٨) على حدبة مسننة لولبية helical saw tooth cam تشغل بتدوير جزء واحد (51) من المرذاذ atomizer بالنسبة للجزء الآخر (70).
- 3232 - An atomizer in accordance with protection element 30 or 31, wherein the pump reciprocating means includes a manually operated latch to temporarily hold the spring in this loaded state before discharging the pressurized fluid. 32 - مرذاذ atomizer وفقا لعنصر الحماية 30 أو ٣١، حيث تشتمل وسيلة الضخ الترددية pump reciprocating means على سقاطة latch تشغل يدويا لإبقاء النابض spring في حالة التحميل هذه بشكل مؤقت قبل تصريف المائع fluid المضغوط.
- 3333 - The atomizer spray, in accordance with any of the protection elements 28 to 30, is prepared so that the pressure of the liquid increases to a pressure of not less than 5 MPa (about 50 bar). 33 - رذاذ atomizer وفقا لأي من عناصر الحماية من ٢٨ إلى ٣٠، يهيا بحيث يزداد ضغط السائل liquid إلى ضغط pressure لا يقل عن 5 ميغاباسكال MPa (حوالي 50 بار bar).
- 3434 - An atomizer according to any of the protection elements 15 to 4 2, which is a metered dose inhaler to produce a mist of liquid medicine for inhalation into the lungs, and the liquid droplets have a mass mean size of no more than 12 micrometer. 34 - مرذاذ atomizer وفقا لأي من عناصر الحماية 15 إلى ٤ ٢ حيث يكون عبارة عن جهاز إستنشاق معاير الجرعة metered dose inhaler لإنتاج رذاذ mist من دواء سائل liquid medicament لاستنشاقه في الرئتين lungs، ويكون لقطرات السائل liquid droplets متوسط كتلي للحجم mass mean size لا يزيد عن 12 ميكرومتر micrometer.
- 3535 - A reciprocating pump device for generating high pressure in a fluid, including a device in accordance with any of protection elements 1 through 4. We further distinguish that the hollow cylindrical piston (17;22;28) is movable in a cylinder. (1), and the aforementioned piston creates a path through which the fluid passes, a high-pressure chamber (4) located in front of the piston inside the cylinder and is supplied with a fluid that passes through the aforementioned path, and a non-return valve member. member (18;23;29) There is in the aforementioned fluid path that moves with the piston but is able to limit the movement directed along the piston axis between a closed position in contact with the valve seat supplied by the piston and an open position that is far from The valve seat, the valve member (18;23;29) is formed and oriented so that it cannot rotate about an axis transverse to the piston axis so that a predetermined surface of it engages the seat. 35 - أداة ضخ ترددية reciprocating pump device لتوليد ضغط عال high pressure في مائع fluid، تشتمل على أداة وفقا لأي من عناصر الحماية من ١ إلى ٤ ١ نتميز كذلك بأن المكبس الاسطواني المجوف hollow cylindrical piston (١٧؛ ٢٢؛ ٢٨) يكون متحركا في اسطوانة cylinder (١)، ويزول المكبس piston المذكور مسارا path يمر خلاله المائع fluid، حجيرة عالية الضغط high pressure chamber (٤) تقع أمام المكبس piston داخل الاسطوانة cylinder وتزود بمائع fluid يمر خلال المسار path المذكور، وعضو صمام لارجعي non-return valve member (١٨؛ ٢٣؛ ٢٩) يوجد في مسار المائع fluid path المذكور الذي يتحرك مع المكبس piston ولكنه قادر على الحد من الحركة الموجهة على طول محور المكبس piston axis بين موضع إغلاق في تلامس مع قاعدة صمام valve seat يزودها المكبس وموضع فتح يكون بعيدا عن قاعدة الصمام valve seat، ويشكل عضو الصمام valve member (١٨؛ ٢٣؛ ٢٩) ويوجه بحيث لا يمكنه الدوران حول محور axis مستعرض لمحور المكبس piston axis بحيث يتعشق سطح محدد مسبقا منه بالقاعدة seat.
- 3636 - A reciprocating pump device according to protection element 35, where the valve member (37) is usually cylindrical and mounted at the front end of the hollow piston (31), and the effective area of the valve base is essentially the same as the piston bore. 36 - أداة ضخ ترددية reciprocating pump device وفقا لعنصر الحماية ٣٥، حيث يكون عضو الصمام valve member (٣٧) عادة اسطوانيا ويركب عند الطرف الأمامي من المكبس المجوف hollow piston (31)، وتكون المساحة الفعالة من قاعدة الصمام مماثلة بصفة جوهرية لفجوة المكبس piston bore.
- 3737 - A reciprocating pump device according to protection element 36, where the valve seat (36) is shaped like a frustoconical cone. 37 - أداة ضح ترددية reciprocating pump device وفقا لعنصر الحماية ٣٦، حيث تكون قاعدة الصمام valve seat (٣٦) على شكل مخروط ناقص frustoconical.
- 3939 - An atomizer in accordance with any of Protections 15 to 34 and 38, contains a nozzle member (54) and a filter (55) after the nozzle. 39 - مرذاذ atomizer وفقا لأي من عناصر الحماية من 15 إلى ٣٤ و٣٨، يحتوي على عضو فوهي nozzle member (٥٤) ومرشح filter (٥٥) بعد الفوهة nozzle.
Independent claims39
156 paragraphs, as filed
A device with a small structure for generating high pressure in a fluid to be atomized
Full description
Background of the invention
This invention relates to a device for generating high pressure in a fluid. This device consists of a piston moving in a cylinder and a valve, both of miniaturised construction. The invention also relates to a high-pressure atomizer containing this device, and its use, preferably for medical purposes.
One of the objects of the invention is to make an instrument of this type and the atomizer containing the instrument of a simpler design, at a lower cost of production and adequate to its function.
And half of the French patent No. 390,699 2-A dispensing apparatus for distributing high-viscosity liquid products such as gels and also for distributing low-viscosity products. The distribution device, according to Figures 2 and 3 of this document, is provided with two valves: an inlet valve and an outlet valve. Valve plates are mounted on a valve spring to prevent product flow during the valve closing phases. Both valves are closed using an auxiliary force generated by a compression spring for each valve. Valve discs are placed so that they can move axially with respect to the hollow piston or with respect to the cylinder, respectively.
The dispensing device according to Figure 1 of French Patent No. 390,699 2-A also contains two valves, consisting of valve members in the form of cambered caps, from which extend fixing lugs with catch portions.
It is provided to install the convex surface cover inside the control hole in the radial wall. During the closing phase of these valves, the circumference of the cap has a convex surface in close contact with the outer surface of the radial wall in each case. During the opening of these valves, the convex cover is bent outward, forming a gap between the circumference of the convex cover and the radial wall, allowing an amount of liquid to pass through it. These convex covers are not mounted on a valve spring and are not capable of moving axially with respect to the piston or cylinder on which they are mounted in any case. The composition according to Figure 1 herein is satisfactory when used to dispense viscous products. This formulation is not reliable enough to dispense low-viscosity products, especially after a certain shelf life.
The distribution devices described in French Patent No. 390 699 2-A consist of two valves, either mounted on two valve springs and capable of moving axially, or not mounted on two valve springs and not portable axially.
One-half of U.S. Patent No. 718,345 4-A is a sprayer in which a hand-actuated trigger moves a hollow piston into motion in a cylinder. The valve member is placed freely within the piston, and in one embodiment (Figure 9a) the movement of the valve member is directed by the piston. Stop means are provided at the inlet end of the piston to limit the movement of the valve member.
In liquid chromatography, for example, relatively small amounts of liquid are usually moved under high pressure through a separating column. In addition, aerosols (aerosols) are produced in medical aerosol therapy, by atomizing or spraying liquid drugs to treat respiratory tract diseases in humans or to treat asthmatic conditions. On the other hand, high pressure is required in usually a relatively small amount of fluid to produce the small droplet sizes needed for an aerosol. In a dose-calibrated inhaler, according to US Patent No. 5,497,944, we spray a volume of
A fluid is fed through a nozzle with a small aperture under a pressure ranging from 5 to 40 MPa (about 50 to 400 bar) to produce an aerosol. The present invention is particularly applicable to dose metering inhalers and similar devices.
General description of the invention
According to one aspect of the invention, a device with a miniature structure is provided for compressing a fluid, and the device includes a cylindrical hollow piston (17; 22; 28, 31, 33) that is moveable in a cylinder (1) and is equipped with a path through it, where the cylindrical hollow piston contains On a widened portion (20, 33) at the inlet or outlet end, the inner diameter is larger than the inner diameter in the remainder of the hollow piston, and the hollow piston has an edge that is machined internally (19, 24); High pressure chamber (4) is located Inside the cylinder in front of the piston; A valve that operates without any auxiliary force arising from a spring, and contains a valve member (18, 23, 29, 37) that has a defined sealing surface at its inlet end. The valve member is oriented and installed in a way that allows movement axially within the hollow piston in its radiating part. The maximum diameter of the valve member is less than the inner diameter of the hollow piston at its radiating portion and greater than the inner diameter at the remainder of the hollow piston; A stop device (19; 24; 32) is provided at the outlet end of the expanding part of the hollow piston to keep the valve member inside the hollow piston; The valve is closed when the valve member rests on the specified anti-drinking surface, and is open when the valve member rests on the stop device at the outlet end of the radiating portion of the hollow piston.
In one embodiment the valve member is normally prevented from rotating about any axis that is transverse to the piston axis.
In another embodiment, the hollow cylindrical piston is movable in the cylinder and provides a path through which the fluid passes, and the high-pressure chamber located in front of the piston provides
The cylinder is filled with a fluid passing through the aforementioned path, and the inlet valve is directed in the path of the said fluid and moves with the piston, but it is also subject to limited directed movement along the axis of the piston between a closed position in contact with the valve base supplied by the piston and an open position that returns from the valve base, and the valve member is formed and directed So that it cannot rotate around any axis transverse to the piston axis, such that a pre-defined surface of it engages with the base.
In US Patent No. 5,497,944, a similar device is described and shown in which the check valve member is a ball, and in such an arrangement the ball can rotate during multiple operations. It has been found that the wear and deformation resulting from high pressure may permanently irritate the ball so that if a different part of its surface is used during successive sealing and sealing operations (because the ball is free to rotate about a transverse axis) there is a tendency for leakage to occur. This can be avoided by using the same surface of the valve member each time, thus allowing the valve member to stabilize at its base to ensure the desired seal. In a preferred arrangement according to the invention, the greater part of the valve member is cylindrical and oriented in a chamber (which may, for example, be the pumping chamber itself or may be a section of the interior of the piston) and the valve member cylinder has an end surface that contributes to sealing the valve it supplies Piston. Another disadvantage of the ball valve which can be avoided by taking advantage of the invention is that the cross-sectional area of the valve must be much smaller than the diameter of the ball and the guide cylinder in which it moves; This leads to a decrease in the force exerted by the valve member on the valve base resulting from the fluid pressure generated during the pressure stroke (forward movement) of the piston. It is preferable that the high force exerted by the valve member on the valve member and/or valve seat is partially deformed elastically to close any small gaps between them.
In the following description, the two terms use the inlet and outlet side or the inlet and outlet side relative to the main direction of fluid flow inside the tool. The term fluid includes both gases and liquids, but the present invention relates mainly to liquids.
The valve member is to some extent displacable on the hollow piston but essentially moves with it.
It is preferable that the shape of the valve member be symmetrical in rotation around a single axis, for example, it takes the form of a circular cylinder or a frustom. Its cross-section is somewhat less than the cross-section of the chamber in which the valve member is mounted in such a way as to enable it to move. This is achieved by one or more channels, preferably extending along the outer surface of the cylindrical valve member, or by using a valve member with a diameter somewhat smaller than the diameter of the chamber in which the valve member is installed in a way that allows it to move.
The valve member is oriented in the chamber in which it is installed in a way that allows it to move; The cylindrical valve member can rotate around its axis depending on the economy, but its axis remains parallel to the axis of the hollow piston. This results in a defined sealing surface at the inlet end of the valve member.
The distance through which the valve member moves relative to the hollow piston is determined by a stop or a stop device that keeps the moving valve member with the hollow piston.
In some embodiments of the invention where the stop is after the outlet end of the valve member,
At least one recess cavity may be required in the outlet end region of the valve member to allow fluid flow between the bumper and the valve member when the valve is open. The cavity, or each cavity, is located either in the valve member at its outlet end or in the stop in the hollow piston.
When the valve member rests on the bumper in the hollow piston, the valve is open. With the valve member resting on the specified sealing surface, the valve is closed.
In fact, a valve member arranged inside the hollow piston does not rub against the inner wall of the hollow piston. The valve member arranged directly in front of the hollow piston tip can rub against the wall of the main pumping cylinder of the tool. In this case, the valve closes
Effectively, it opens when the hollow piston moves, due to friction between the valve member and the cylinder wall.
It is preferable that the cylinder be made of plastics and the hollow piston made of metal or plastics. The valve member material is chosen, in terms of hardness, to complement the hardness of the hollow piston material. This material may be metal, ceramics, glass, gemstone, plastic, or elastomer. The valve member is preferably made of one piece.
When the fluid is absorbed, the high-pressure chamber is connected to the fluid supply via a hollow piston. During the intake stroke of the hollow piston, fluid flows through the hollow piston and pushes the valve member into the high-pressure cylinder chamber. During the exhaust stroke of the hollow piston, the valve base is sealed by a high-pressure seal on the specific watertight surface of the valve member.
The device according to the invention used to generate high pressure in a fluid is connected to the fluid source at its inlet end. The chamber with the current pressure is connected to another device in which the fluid is transmitted under high pressure. The hollow piston or cylinder is connected to a drive device that conducts a relative movement between the hollow piston and the cylinder and exerts the force required to generate high pressure.
In one embodiment, the preferred cylinder valve member may be so mounted as to enable it to move completely within the hollow piston. The outlet end of the hollow piston has an inner diameter larger than the inner diameter of the remainder of the hollow piston. The length of the expanding portion of the hollow piston is somewhat greater than the length of the valve member. The diameter of the valve member is essentially equal to the inner diameter at the radiating end of the hollow piston. The outlet end of the hollow piston is shaped internally to form a rim either on its total circumference or on part of its total circumference and acts as a stop that keeps the valve member inside the hollow piston. The base of the radiating portion that forms the base of the valve may be flat or conical. For example, it may take a flow cavity
Fluid in the outlet side of the valve member forms a graduated channel. A fluid flow cavity may form in the bumper, for example in the form of an indentation at the edge of the rim.
In a variant of this embodiment, the valve member may be arranged entirely within the piston.
The hollow at the edge of its entrance. The stop will then be located at the outlet end of the expanding part and the limiting sealing surface will be located on the formed flange at the inlet end of the hollow piston.
In another embodiment, the hollow piston consists of a thin-walled tube formed at its end that projects into the cylinder and provided with an encircling constriction at the end of the valve member's space. The cylindrical valve member is oriented and installed in a way that allows it to move in the space between the formed flange and the surrounding waist. Another thick-walled tube may be pushed into the inlet end of the hollow piston, its outer diameter equals the inner diameter of the hollow piston. This thick-walled tube is also firmly connected to the hollow piston, preferably extending to approximately the circumference of the hollow piston. The thick-walled tube acts as a displacement member and facilitates the absorption of fluid into the high-pressure chamber without the actual need for pressure. It is preferable that the tube be thick-walled made of plastic.
In a variation of this embodiment, the valve member may be completely mounted within the hollow piston at its inlet end. The bumper will then be located at the circumferential waist and the limiting sealing surface will be located at the edge formed at the inlet end of the hollow piston.
In another embodiment, the hollow piston consists of a thin-walled tube containing a thick-walled tube with an outer diameter equal to the inner diameter of the hollow piston and in fixed contact with the hollow piston. The thick-walled tube acts as a displacement member and facilitates the absorption of fluid without the actual need for pressure.
The inlet end of the hollow piston is wide. At the expanding end, the hollow piston is firmly connected to a closing member whose outer diameter is larger than the outer diameter of the radiating inlet end of the hollow piston. The closing member has a lower part
depression is open on the side opposite the expanding end of the hollow piston. At the base of the low part there is an opening that serves as an inlet for the fluid. The base of the depressed part may be conical or flat; It forms the specific waterproof surface.
The valve member coordinates in the lower part of the closing member; This valve is directed so that it moves an axial movement in the lower part. The outer diameter of the valve member is smaller than the inner diameter of the lower part, but preferably this diameter should be larger than the inner diameter of the hollow piston in the part that protrudes into the cylinder. The valve member may contain, at its outlet end, at least one cavity through which fluid flows into the chamber at normal pressure during the intake stroke of the hollow piston.
It is preferable that the stop of the valve member be the tip of the displacement member that protrudes into the expanding part of the hollow piston, or it is the place of transition from the non-radiating part of the hollow piston to the tip of its radiating inlet if the tip of the displacement member is located in the non-radiating part of the hollow piston.
It is preferable that the hollow piston with a widened inlet tip be made of metal.
It is preferable that the displacement member and the closing member be made of plastics. The valve member may be made of plastic or a metal material.
It is particularly important to use the device according to the biopsy to generate high pressure in a fluid in an atomizer to spray the fluid without the use of propellant-free spraying.
According to another aspect of the invention, an atomizer is provided for spraying a fluid, consisting of an upper housing part, a lower housing part, a pump housing, a nozzle, a blocking mechanism, a spring housing, a spring and a supply container. where :
The pump housing is fixed to the upper housing, at one end of which there is a nozzle member containing the nozzle.
It includes a device according to the invention comprising a hollow piston containing a valve member as described above,
The drive flange that holds the hollow piston is located in the upper housing,
The locking or ratcheting assembly which is located in the upper housing portion,
The spring housing containing the spring is located in the lower housing, which is rotatably mounted by a rotary bearing on the upper housing,
The part of the lower housing that is mounted on the spring housing in the axial direction
axial direction
Other aspects of the invention are mentioned in the attached protection elements, but changes and combinations of certain features can be made without deviating from the scope of the invention. Certain preferred features are specified in the child protection elements.
Other favorable features will now be described. Preferably, the vaporizer should be an inhaler with a calibrated dose.
The hollow piston valve member corresponds preferably to a device of the invention as set forth herein. It partially protrudes into the pump housing cylinder and is mounted in the cylinder in a way that can rotate axially. The hollow piston containing the valve member exerts a pressure of 5 to 60 MPa (i.e., about 50 to 600 bar), and preferably 10 to 60 MPa (i.e., about 100 to 600 bar) on the fluid at the high-pressure end at the moment of release. The spring.
It is preferable that the nozzle in the nozzle member be microstructured, i.e. produced using microtechnology. Microstructured orifice organs have been described, for example in US Patent No. 5,472,143.
The orifice organ consists, for example, of two plates of glass and/or silicon closely connected together, at least one of the plates containing a finely structured canal.
One or more microstructured channels connecting the inlet raft of a nozzle to its outlet end. And there is
At the exit end of the nozzle there is at least one circular or non-circular opening with a diameter of not more than 10 micrometers (um). The term scale in this regard refers to hydraulic diameter. The diameter of this type of tool is generally less than 100 micrometers, preferably 1-20 micrometers.
Spraying may be carried out using nozzles in the nozzle in directions parallel to each other or in an inclined direction relative to each other. In a nozzle member having at least two nozzle openings at the exit end of the nozzle, the direction of spray may be inclined with respect to each other
At an angle ranging from 20 to 160 (degrees), and preferably at an angle ranging from 60 to 150. And it has
Spray directions meet in the vicinity of the nozzle nozzles.
In the pump housing, a check valve with or without a spring bias may be provided between the nozzle orifice and the high-pressure chamber of the cylinder. This non-return valve closes the high-pressure chamber in the atomizer's resting state, protects the fluid from entering air and, if necessary, prevents the volatile component of the fluid from evaporating from the pump housing. The non-return valve opens itself as soon as the fluid pressure in the chamber with the current pressure exceeds a minimum value and the fluid flow begins; It closes itself as soon as the fluid stream empties. The non-return valve, for example, may be a ball valve. This valve may consist of a flexible plate that is clamped on one side and remains like a flap (dangling end) at the outlet end of the high-pressure chamber. In another embodiment, the valve may consist of a disk, preferably of flexible material, clamped along its circumference, and pierced with a pin. This hole allows the fluid stream to pass through it to reach the nozzle as soon as the pressure in the fluid exceeds a minimum value. After the fluid stream empties, the hole is closed again.
It is preferable to install the valve member at the end of the cylinder that faces the nozzle member.
The locking or ratcheting assembly contains a spring, preferably a cylindrical helical compression spring, as a store of mechanical energy.
mechanical energy. The spring acts on the driven flange as a jumping member whose movement determines the location of the blocking member. The distance traveled by the driven lip is precisely determined by an upper and lower bumper. It is preferable to tighten the spring with an external torque through a force stepping-up device, such as a helical sawtooth thrust cam. The force is generated when the upper housing part rotates against the spring housing in the lower housing part. In this case the upper housing and driven flange have a single or multiple sawtooth wedge arrangement.
Compositions of this general type are described in US Patent No. 4260-082 and German Patent Application No. 2291135.
The sealing member containing sealing and engagement surfaces is arranged around an annularly driven flange. This member consists, for example, of a plastic or metal ring whose shape changes inherently in the radial direction. The episode is arranged in
Level for right angles on the axis of the atomizer. After the spring is aligned, the sealing surfaces of the sealing member move toward the driven flange and prevent the spring from releasing. The dam member is operated by a button. The actuating bottom button is connected to the dam member. To operate the dam combination pushes
The operating button is oriented parallel to the plane of the ring, preferably in an atomizer; Thus, the changeable shape of the ring changes in the plane of the ring to release the lip for movement by the spring.
The preferred seal member and spring are described and shown in German Patent Application No. 195452267 filed by Microparts but assigned to Boehringer Ingelheim International GmbH.
The vaporizer may contain a mechanical counter consisting of a screw threaded spindle mounted on the spring housing. The shaft axis extends in the outer surface area parallel to the atomizer axis. The shaft is mounted, at its ends, by means of a rotating bearing on the spring housing. The shaft has teeth at the end closest to the upper housing. On the edge of the upper housing there is at least one cusp that engages the teeth at one end
Column when the two housing parts rotate relative to each other. It rests on the column with a slider equipped with a rotation prevention means and is engaged with its teeth.
The preferred meter is described and shown in German Patent Application No. 033.9 49 195 dated December 8, 2019, filed by Microparts but assigned to Boehringer Ingelheim International (GmbH).
The lower housing is pushed axially onto the spring housing and covers the assembly, shaft drive and fluid storage container. The position of the slide can be seen through a recess in the lower housing and can be read on a scale, for example on the lower housing.
When the atomizer is switched on, the upper housing rotates relative to the lower housing, i.e. the lower housing that holds the spring housing inside it. At the same time, the spring is compressed and aligned by the spiral drive cam, and the tooth assembly self-locks. It is preferable that the rotation angle represents an integer part of the angle, for example 180. At the same time, when the spring is aligned, the driven part of the upper housing moves a certain distance, pulling the hollow piston inside the cylinder into the pump housing, due to which part of the fluid goes from the storage vessel to the high-pressure chamber located in front of the nozzle.
By the action of gears, which consist of a piston at one end of the shaft and a rack or several racks on the edge of the upper housing, the relative movement of the two housing parts is activated and transformed. Rotational movement of the shaft and displacement movement of the slide on the shaft. Each time the atomizer is turned on, the lubricant moves a certain distance along the shaft.
The position of the lubricant indicates how much of the fluid to be sprayed has already been drawn from the storage container and how much is still available. The slide on the shaft can be reset if necessary using the resetting lug.
If desired, several (preferably collapsible) replaceable storage containers holding the liquid to be sprayed into the vaporizer can be inserted one by one and used. The storage vessel is not pressurized or not substantially pressurized. The fluid pressure in the storage vessel is in any case substantially less than the pressure generated by a mechanically operated atomizer in the high-pressure chamber. The storage container, for example, contains a liquid containing a drug
drug
A convenient receptacle has an outer portion that is fixed at the top and an inner portion that collapses when the fluid within is removed as described in U.S. Pat. No. 5,316,135.
The spraying process begins by gently pressing the start button. The dam structure then opens a way for the orbital part to move. The spring, after being aligned, pushes the piston to the pump housing cylinder. The fluid leaves the atomizer nozzle in the form of a mist.
The parts of the atomizer are made of... Suitable for performing its function. The atomizer housing and other parts, as far as their function allows, should preferably be made of plastic, for example by injection molding. Physiologically acceptable materials are used for medical purposes.
According to the invention, the vaporizer is used, for example, to produce medical aerosols without the use of propellant gases. It can produce an inhalable aerosol with a mass average particle size (droplet) of about 5 micrometers. These small particles (with an average particle size of less than 12 micrometers) are necessary to penetrate directly into the lungs. The amount discharged is preferably about 15 microliters.
The following active substances are disguised as examples of pharmaceutical compositions in the form of aqueous or ethanolic solutions, depending on the solubility of the active substance: Berotec, Berodual, Flunisolide, Atrovent, Salbutamol,
Budesonide, Combivent, tiotropium, oxivent and appropriate peptides.
Solutions may also contain pharmaceutically acceptable excipients.
The preferred device according to the invention is used to generate high pressure in a fluid and the preferred atomizer containing this device has the following advantages:
- The tool has a valve that operates without auxiliary force (produced by the spring)
It closes due to flow resistance on the valve member or due to friction on the cylinder wall.
The valve member is considered tight to pressures usually exceeding 3 MPa (30 bar).
- The valve member is made of one piece; It is easy to make and install.
- The valve closes very quickly due to the short distance traveled by the valve member to reach the specified sealing surface.
- The valve has a high sealing action.
- Because the symmetrical valve member is oriented so that it rotates about a single axis, a surface is produced
A sealing limiter that is impermeable to high pressure through a very large number of strokes of the hollow piston.
- The dead space of the current pressure chamber can remain very small.
- The vaporizer can be operated safely and easily even by untrained persons, to guide
Pulsator to operate the spraying process.
The vaporizer works without propellant gas and therefore does not pose an environmental risk.
- The fluid storage vessel is not pressurized or substantially non-pressurized.
The movement of the dam member is coupled to the rotary movement to direct the spring in a simple way.
- In a preferred embodiment the atomizer consists of low-wear mechanical components
Nothing else. Operates over long periods of time reliably.
- Because of the specific bearing surfaces of the rotated part, the amount of fluid is measured very accurately.
- The vaporizer can be made at low cost and easily installed.
- The mechanical timer works automatically when the vaporizer is turned on; It has a permissible tolerance that is not critical
uncritical of tolerance, easy to install and operate safely and reliably.
- The meter is inaccessible when the atomizer is used correctly and cannot be disabled
falsified by accident.
- The meter can be adapted to any number of fluid flows from the storage vessel and to several vessels
Different storage used with one atomizer.
- The meter is integrated into the atomizer and does not occupy additional space.
- There are no materials that can pass from the meter to the material to be sprayed.
Preferred embodiments of the invention will be described, for example, by reference to drawings where:
Brief explanation of fees
Figures 1a, 1b and 1c: Between the shapes in order is a longitodinal section
For a first embodiment of a pump used to generate high pressure in a fluid according to the invention, an oblique view of its hollow piston and an oblique view of its valve member;
Figures 2a, 2b and 2c are identical views of a second embodiment;
Figures 2d, 2e and 2f are identical views of a modification of the second embodiment;
Figure 3 represents a longitudinal section of a third embodiment; And
Figures 4a and 4b represent two longitudinal cross-sections of a dosed derivation administration
Calibrated according to the invention under different operating conditions.
The various embodiments of the pumping device have been described above in general terms but will now be appended in additional detail by reference to the drawings.
Detailed description
Figure 1A shows an inclined longitudinal section view of a first embodiment of the device of the invention used to generate high pressure in a fluid. In cylinder (1), the hollow piston (17) and valve member (18) appear in the closed position of the valve.
Figure (1b) shows an inclined longitudinal section view through the hollow piston (17) with the shaped end (19). At the outlet end of the hollow piston there is a widened portion (20) in which the valve member (18) is directed and mounted in a way that allows it to move axially. The entrance end of the widened part (20) shall be chamfered or level.
Figure 1c shows an inclined longitudinal section view of the valve member. Cylindrical (18). Both ends of the valve member are level and located perpendicular to the axis of the valve member. The valve member (18), for example, has four stepped channels or flats (21) on its outer surface. To facilitate flow. Fluid through the formed tip (9a), intoned lip. When the valve opens, the ends of the channels (21) are radially toward the inside of the lip. The edge of the valve member (18) that rests on the base of the hollow chamber (20) is chamfered.
The diameter of the valve member (18) is less than the diameter of the expanding part (20), and thus the valve member (18) can move without being limited by the expanding part (20) approximately.
To install the valve member (18), it is pushed into the expanding part (20) before the outlet end (19) of the hollow piston is formed.
To withdraw the fluid, the hollow piston is partially lifted from the cylinder, and as a result the valve opens on its own. The fluid flows through the cavity (7) in the hollow piston and pushes the valve member into the high-pressure chamber (4). To expel the fluid, the hollow piston (2) is pushed into the cylinder (1), and as a result the valve closes itself, at almost the same moment, and a high pressure is generated in the fluid.
Figure 2a shows an oblique longitudinal cross-section view of a second embodiment of the device of the invention used at high pressure in a fluid. In cylinder (1), the hollow piston (22) and valve member (23) appear.
In the closed position of the valve. The diameter of the valve member is less than the inner diameter of the hollow piston.
Figure 2b shows a view of an inclined longitudinal section through the hollow piston (22) with the machined outlet tip (24) forming the driven edge and encircling constriction.
(25). The thick-walled tube (26), which acts as a displacement body, may be forced into the hollow piston (22) and fixed inside it.
Figure 2c shows the valve member (23) at an angle. At the outlet end of the valve member there is an indentation extending towards the radius (27) in the form of a transverse slot to facilitate the flow of fluid when the valve opens.
Figure 2d shows an alternative image of the second embodiment in the form of an oblique longitudinal section. In cylinder (1), the hollow piston (28) appears, optionally with the displacement body (26), and the valve is in the closed position. The diameter of the valve member (29) is less than the inner diameter of the hollow piston.
Figure 2e shows an inclined longitudinal section view, through the hollow piston (28) with the formed outlet tip (24) and the surrounding waist (25). At least one notch (30) in the form of a recess or notch is provided on the formed outlet end (24) to facilitate the flow of fluid when the valve is opened. There may be convexity instead of grooves.
Figure 2f shows the valve member (29) at an angle. In this case, the valve member is a straight cylinder with no recesses.
Figure 3 shows an oblique longitudinal cross-section view of the third embodiment of the device of the invention used to generate high pressure in a fluid. In the cylinder (1), the hollow piston (31) appears, which contains a displacement body (32). At the end of the cylindrical radiating inlet (33) the hollow piston is installed with a closing member (34) with the lower part (35) and the bore (36). In the notch there is an axially moveable guide valve member (37), which may be provided with a slot (38) in the form of a cavity at its outlet end.
Embodiments of the device according to the invention used to generate high pressure in a fluid and shown in Figures 2a through 3 operate in the same manner as previously described by reference to Figure 1a.
Figure (4a) shows a longitudinal section through the preferred atomizer described in detail above in the case in which the spring is directed, and Figure (4b) shows a longitudinal section through the atomizer in the case in which the spring is fired.
The upper housing (51) contains the pump housing (52) on the end of which the holder (53) for the atomizer nozzle is mounted. Preferably, this fastening device is as described in German Patent Application No. 51-p19536903.3 dated October 4, 1995 (and a similar Patent Cooperation Treaty application filed at the same time as this application in the joint name of Boehringer Ingelheim International GmbH) International) and inventors). The fastener has a foot member (54) and a filter (55). The hollow piston (57) mounted in the cup-shaped driven flange (56) of the seal assembly (57) partially protrudes into the pump housing cylinder. The hollow piston carries a valve member (58) at its end. The hollow piston is sealed by means of a drinking stop (59). Inside the upper housing portion is the annular mount (i.e. the opposite annular protrusion (60) on the lip) on which the lip rests when the spring is released. On the pivot end of the cup-shaped driven flange is the mount (61) which holds the driven flange when directing the spring. After guiding the spring, the general annular seal member (62) moves between the mount (61) and the support (63) in the upper housing portion, either by its elasticity or (or when more rigid) by an external spring (not shown). The operating button (4 6) is connected to the dam member, which may move physically or out of shape to release the anchor (61). The upper housing part ends with the mouth piece (65) and is closed with a protective cap (66) on which it can be installed.
The spring housing (67) with compression spring (68) is mounted in a rotatable manner on the upper housing by means of a snapping lug (69) and a swivel bearing. And he pays
The lower housing portion (70) is over the spring housing and rotates with it to operate a spiral toothed cam drive (not shown) to cock the atomizer (moving it from the location of Figure 6B to the tip of Figure 6A). Inside the spring housing there is a replaceable storage container (71) for the fluid (72) to be sprayed. The storage container is provided with a stopper (73) through which the hollow piston protrudes into the storage container and its tip is immersed in the fluid.
The shaft (74) of the mechanical counter is installed on the outer surface of the spring housing. At the end of the shaft opposite the upper housing, there is a drive pinion (75). The sled (76) rests on the pole.
The embodiments shown in the drawing may change. The parts may be used together in a manner different from the method shown in the drawing.
Example (1): A miniature high-pressure device used in a cosmetic atomizer
cosmetic atomizer
The valve portion of a cosmetic atomizer according to Figure 1a consists of a cylinder made of polyetherether-ketone having an inner diameter of 2.5 millimeters (mm) and an outer diameter of 8 mm. The high-pressure chamber is closed by a nozzle carrier plate. On this board there is a nozzle with a diameter of 25 micrometers and a nozzle channel length of 2 mm.
A hollow piston made of reinforced plastics with an outer diameter of 2.48 mm and a bore of 0.5 mm is pushed into the cylinder. The hollow piston can be pushed into the cylinder a distance of 45 mm, with a stroke of 24 mm. The hollow piston is drilled to an internal diameter of 1.85 mm along a length of 5.0 mm at the outlet end. The base of the chamber formed in the hollow piston is beveled. The shape of the outlet end of the hollow piston changes thermally.
The valve part is a cylinder made of polypropylene, 3 mm high and 1.6 mm in diameter. There are four graduated channels in an image
Cavities in the outer surface. The valve member may be displaced axially by about 0.5 mm within the hollow piston.
The delivery volume is equivalent to about 116 mm3. The pressure in the fluid is about 3 MPa (30 bar).
This vaporizer is used to spray hair spray.
1 sheet
Sheet 1
98 members in 39 offices
Priority claims2
| Document | Office | Kind | Date |
|---|---|---|---|
| 19536902 | Germany | A | |
| 195369025 | Germany | – |
Members98
| Document | Office | Kind | |
|---|---|---|---|
| UY24339A1 | Uruguay | A1 | |
| CA2232151A1 | Canada | A1 | |
| CA2473681A1 | Canada | A1 | |
| CA2551891A1 | Canada | A1 | |
| CA2551999A1 | Canada | A1 | |
| DE19536902A1 | Germany | A1 | |
| WO9712687A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AU7287096A | Australia | A | |
| HRP960448A2 | Croatia | A2 | |
| ZA968317B | South Africa | B | |
| CO4560418A1 | Colombia | A1 | |
| NO981521D0 | Norway | D0 | |
| NO20074487L | Norway | L | |
| NO981521L | Norway | L | |
| PE29098A1 | Peru | A1 | |
| TR199800586T1 | Türkiye | T1 | |
| EP0853501A1 | European Patent Office (EPO) | A1 | |
| PL325961A1 | Poland | A1 | |
| AR003794A1 | Argentina | A1 | |
| EE9800107A | Estonia | A | |
| BG102345A | Bulgaria | A | |
| IL123634D0 | Israel | D0 | |
| SK42698A3 | Slovakia | A3 | |
| CN1198689A | China | A | |
| CZ101598A3 | Czechia | A3 | |
| BR9611140A | Brazil | A | |
| HU9900741A2 | Hungary | A2 | |
| HUP9900741A2 | Hungary | A2 | |
| TW364041B | Taiwan Province of China | B | |
| KR19990063707A | Republic of Korea | A | |
| YU53996A | Yugoslavia, later Serbia and Montenegro (until 2006) | A | |
| NZ320179A | New Zealand | A | |
| US5964416A | United States of America | A | |
| HK1015304A1 | Hong Kong, China | A1 | |
| JPH11512649A | Japan | A | |
| HU9900741A3 | Hungary | A3 | |
| HUP9900741A3 | Hungary | A3 | |
| AU730797B2 | Australia | B2 | |
| EG21374A | Egypt | A | |
| EE03519B1 | Estonia | B1 | |
| IL140221D0 | Israel | D0 | |
| RU2179075C2 | Russian Federation | C2 | |
| US6402055B1 | United States of America | B1 | |
| EP1214985A2 | European Patent Office (EPO) | A2 | |
| EP1214985A3 | European Patent Office (EPO) | A3 | |
| HU221232B1 | Hungary | B1 | |
| US2002130195A1 | United States of America | A1 | |
| CN1091660C | China | C | |
| US6497373B2 | United States of America | B2 | |
| JP2003056458A | Japan | A | |
| UA54402C2 | Ukraine | C2 | |
| MY115214A | Malaysia | A | |
| US2003080210A1 | United States of America | A1 | |
| PL185631B1 | Poland | B1 | |
| PL185789B1 | Poland | B1 | |
| SK283515B6 | Slovakia | B6 | |
| EP0853501B1 | European Patent Office (EPO) | B1 | |
| AT248028T | Austria | T | |
| ATE248028T1 | Austria | T1 | |
| DE69629708D1 | Germany | D1 | |
| IL140221A | Israel | A | |
| DK0853501T3 | Denmark | T3 | |
| BG64081B1 | Bulgaria | B1 | |
| JP3488717B2 | Japan | B2 | |
| PT853501E | Portugal | E | |
| SI0853501T1 | Slovenia | T1 | |
| ES2201204T3 | Spain | T3 | |
| US6726124B2 | United States of America | B2 | |
| HRP960448B1 | Croatia | B1 | |
| IL123634A | Israel | A | |
| DE69629708T2 | Germany | T2 | |
| KR100431011B1 | Republic of Korea | B1 | |
| US2004178227A1 | United States of America | A1 | |
| YU49228B | Yugoslavia, later Serbia and Montenegro (until 2006) | B | |
| CZ295103B6 | Czechia | B6 | |
| US6918547B2 | United States of America | B2 | |
| US2005252990A1 | United States of America | A1 | |
| SA919B1This record | Saudi Arabia | B1 | |
| SA97170624B1 | Saudi Arabia | B1 | |
| US7104470B2 | United States of America | B2 | |
| US2006285987A1 | United States of America | A1 | |
| EP1214985B1 | European Patent Office (EPO) | B1 | |
| AT352379T | Austria | T | |
| ATE352379T1 | Austria | T1 | |
| DE69636875D1 | Germany | D1 | |
| PT1214985E | Portugal | E | |
| JP2007092762A | Japan | A | |
| DK1214985T3 | Denmark | T3 | |
| SI1214985T1 | Slovenia | T1 | |
| DE69636875T2 | Germany | T2 | |
| CA2232151C | Canada | C | |
| ES2280442T3 | Spain | T3 | |
| JP2009019637A | Japan | A | |
| CA2551891C | Canada | C | |
| JP2010138913A | Japan | A | |
| CA2473681C | Canada | C | |
| CA2551999C | Canada | C | |
| JP5015896B2 | Japan | B2 |
Numbers
- Publication
- 919
- Application
- 97170624
Titles2
- Arabic
- أداة ذات تركيب مصغر لتوليد ضغط عالٍ في مائع يراد تذريته
- English
- A device with a miniature structure for generating high pressure in a fluid to be atomized
Classification
- CPC, 17
- A61M15/0065
- B05B11/00
- A61M15/00
- A61M2205/7545
- F04B53/125
- A61M15/0068
- A61M15/0071
- A61M15/0081
- Y10T137/7909
- Y10T137/7916
- Y10T137/7913
- B05B11/026
- B05B11/1001
- B05B11/1067
- B05B11/108
- B05B11/109
- B05B11/1091
- IPC, 11
- A61M11 00
- A47K5 12
- A61M15 00
- B05B9 043
- B05B11 00
- B05B11 06
- B65D83 76
- F04B9 14
- F04B53 10
- F04B53 12
- F16K