Use of a container for medical liquid

A container for medicinal liquid

Full description

Corresponding reference for related requests

This application claims priority over the application serial number 093772/60, filed on July 23, 1998 AD.

Background of the invention

1. Field of invention

The present invention relates to a container for a medicinal liquid, where the container is gas-tight and liquid-tight. 2. Related technology

European Patent No. A2 4 9 0 82 1 0 A bottle-shaped package comprising a fixed-shaped outer container and an inner container placed inside the outer container in the form of an easily deformable bag containing the filling material. The preform is produced by co-extrusion of two coaxial tubular portions. The two parts consist of two thermoplastic materials that are not connected together. The initial shape is expanded into a blow molding mold. A welded seam is provided at the flat bottom of the inner vessel. The flat bottom, formed on the outer bowl, contains a slit-shaped opening. The outer bowl and the inner bowl are connected together by a positive locking relationship in the drain hole area. This packaging is produced in essentially one operation.

The filling material is drained from the container using a pump located in the drain hole.

The inner vessel deforms when its volume shrinks as a result of pumping. The air passes into the space

It is located between the outer vessel and the deformed inner vessel, through an open slit in the flat bottom of the outer vessel, thus preventing a drop in pressure in this intermediate space. The inner bowl is not in constant contact with the outer bowl, except in the area of the drain hole. The package may be provided with a dip tube extending almost to the flat bottom and keeping the inner container in the extended position. This package can only be used acceptably and completely emptied when it is in a certain position in the vacuum.

European Patent No. Al 165 620 0 describes a tubular bag made of composite foil. The composite foil contains a plastic foil placed on the outer side and a metal foil placed on at least one inner side. The tubular sac is closed at both ends in a pouch-like shape. The bag is provided with a desired rupture site, by which the bag can be opened reliably at that point. A tubular bag of this type is suitable for storing hardenable material that is expelled from the tube by means of expulsion.

European Patent No. Al 068653 0 describes a flexible, collapsible container used in one cycle, made of thin film, and used in a suction or feeding bottle that can be used several times. One end of the bowl is open while the other end is closed with a welded seam, and the bowl is provided with a tongue portion. The lingual part is placed in a gap provided at the bottom of the suction or feeding bottle. This ensures that the bag-like container remains in a constantly extended position inside the suction or feeding bottle.

General description of the invention

The invention aims to produce a vessel used in one cycle that is highly economical without adversely affecting its suitability for use, and to facilitate its use.

The object of the present invention is to provide a container for a medical liquid, which is... It is gas-tight and liquid-tight, and has an appropriate filling volume for its intended use. And it is undermined

The vessel is such that it is easily moldable and non-reversible at slightly low pressure

Pre-defined so that it can be substantially unloaded.

According to the present invention, the container contains a foil bag that is closed at both ends. When the pressure difference between the inside of the vessel and its surroundings is less than 3.00 hectopascal (hpa) (300 millibar (mbar), the laminated bag is susceptible to deformation by external pressure and collapses. The vessel also contains a flange that is fixed in shape and mounted in a manner A seal on the foil bag and the flange is a removable connecting element for mounting the receptacle to a discharge connectionmenrber.

The foil bag is closed at at least one end by at least one welded seam extending substantially transversely with respect to the axis of the bag. The protruding lip has a fixed sealing location. It also provides a place for fluid drainage in the protruding lip area, which is fixed in shape.

According to the present invention, the bowl has many advantages over those of traditional bowls. For example, a bowl crown according to the present invention is economically feasible, suitable for use in one cycle and its production requires the use of a small amount of material.

In addition, the vessel according to the present invention may be produced under sterile condition and filled and sealed under sterile conditions. It may also be used for inhalation medications, usually supplied as solutions in ethanol, water, or a mixture of ethanol and water.

The liquid is drained from the vessel according to the present invention under sterile conditions, such that air is not sucked into the vessel upon draining. Thus, the liquid does not come into contact with air, oxygen, or carbon dioxide.

The vessel according to the present invention also allows for the drainage of a medical liquid free of gases and bubbles.

The vessel is sealed in accordance with the present invention so that the diffusion of liquids and gases is as little as possible. The container may be filled and stored for several years, depending on the specific drug used, while meeting the requirements of all official pharmacopoeias.

The vessel is easily deformed at slightly low pressure. The vessel according to the present invention also remains flat and extended in the collapsed position, so that it maintains its initial length after use.

In addition, the vessel of the present invention does not require a valve to equalize pressure after draining part of the liquid, and the vessel can be substantially emptied, even in the receptive position and when inverted.

The foil bag according to the present invention is attached only to the fixed protruding flange and is not secured to any sleeve, if provided.

The container filling volume may be easily adjusted to a predetermined value within a specified range by changing the length and/or diameter of the foil bag. The vessel can also be filled before closing it, and before making the single or second welded seam. Thus, there is no need for a separate closing method.

The container may be used with or without a cover. If the container is placed in a cover, it is protected from external damage.

The liquid is stored in the container according to the present invention, where it is protected from the influence of light by an opaque foil bag or by an opaque cover that is closed in all directions.

In addition, the vessel according to the present invention can be placed in and removed from a drainage device in a simple manner without any rotational movement.

Brief description of fees

The foregoing and other features and advantages of the invention will become apparent from the following more specific description of a preferred embodiment of the invention, as shown in the attached drawings.

Figure 1: A perspective drawing of a first embodiment of a closed foil bag according to the present invention

At both ends.

Figure 2: A perspective drawing of a second embodiment of a sealed foil bag according to the present invention

At both ends.

Figure 3 shows a perspective drawing of a third embodiment of a closed foil bag according to the present invention

At both ends.

Figure 4: A cross-sectional view of a first embodiment of a protruding flange according to the present invention.

Figure 5a: shows a cross-sectional view of a second embodiment of a protruding flange according to the present invention.

Figure 5b: shows a cross-sectional view of a second embodiment of the protruding flange taken along line 5-5 of Figure 5a.

Figure 6: shows a cross-sectional view of a third embodiment of a protruding flange according to the present invention.

Figure 7 shows a cross-sectional view of a fourth embodiment of a protruding flange according to the present invention.

Figure 8a: shows a view of a single-segment protruding flange according to the present invention, which is placed on the side of the foil bag.

Figure 8b: Shows a detailed view of a cross-section of the laminate foil used to make the laminated bag in Figure 8a.

Figure 9a: shows a side view of a first embodiment of a welded seam according to the present invention.

Figure 9b: shows a cross-sectional view of a welded seam taken along line 9-9 of Figure 9a.

Figure 10a: shows a side view of a second embodiment of a welded seam according to the present invention.

Figure 1B: shows a cross-sectional view of a welded seam taken along line 10-10 of the figure.

10a.

Figure 11a: shows a side view of a third embodiment of a welded seam according to the present invention.

Figure 11b: A step view of the welded seam in Figure 11a is shown.

Shapes

12a-12g: show a series of perspective drawings for making and filling a vessel according to a first embodiment of the present invention.

Shapes

13a-13f: Show a series of perspective drawings of making and filling a vessel according to a second embodiment of the present invention.

Figure 14: shows a partial cross-sectional view of a vessel according to the present invention.

Figure E1a: shows a cross-sectional view of a first embodiment of a connecting portion of a receptacle according to the present invention.

Figure 5 1b: A side view of one end of the vessel in Figure 5a shows.

Figure 16a: shows a cross-sectional view of a second embodiment of a connection portion of a receptacle according to the present invention.

Figure 16b: A side view of one end of the vessel in Figure 16a shows.

Detailed description

A preferred embodiment of the present invention is described by reference to figures where similar reference numbers indicate identical or functionally similar elements. While special formations and arrangements are explained, it should be understood that they are for illustrative purposes only. Those skilled in a related technique will realize that other configurations and arrangements can be used without departing from the principle and scope of the invention.

An object of the present invention is to provide a container for a medical liquid, which is gas-tight and liquid-tight, and has a filling volume suitable for the intended purpose of its use. The vessel is collapsed so that it is easily moldable and non-reversible at a slightly low pressure in a predetermined manner so that it can be substantially emptied.

According to the present invention, the container contains a foil bag that is closed at both ends. When the pressure difference between the inside of the container and its surroundings is less than 300 hectopascals (300 mbar), the foil bag is susceptible to deformation by external pressure and collapses. The container also has a fixed, protruding lip that mounts leak-proof on the foil bag. The protruding flange is a releasable coupling element for mounting the vessel to a drainage coupling member.

The laminated bag is closed at at least one end by at least one welded seam running substantially transverse to the axis of the bag. The protruding lip has a fixed shape to prevent scratches. It also provides a location for the liquid lip in the protruding lip area, which is stable in shape.

In another embodiment, the collapsible laminated bag can be deformed and undermined by external pressure at a pressure difference of less than 150 hPa (150 mbar) or preferably less than 0.8 hPa (80 mbar).

The foil bag can be closed with a welded seam at both ends. In this case, a fixed, protruding lip is welded to the side of the foil bag in a way that prevents drinking, and it is preferable to weld it near one end of the foil bag. However, the foil bag can also be closed at one end with a welded seam, and at the other end with a drinking-proof lip. In this case, one end of the foil bag is welded to the flange, preferably at its circumference.

The laminar bag may be made of a tube without a welded seam that extends in the axial direction of the laminar bag. In an alternative embodiment, the foil bag may have one or two welded seams extending in the longitudinal direction. The laminar bag may be in the form of a flat bag or a bag with side folds. Preferably a bag that has a welded seam that stretches in the direction

Longitudinal.

In one embodiment, the foil bag is made of a thin sheet of metal or metal alloy, preferably aluminum, gold or copper, or of a plastic material, preferably a thermoplastic material. In another embodiment, the foil bag is made of a composite film of plastic and metallic material. It is preferable for the composite foil to contain two or three foils connected together. The foil bag may also contain a plastic film on which a layer of metal, glass or ceramic is applied, for example by vapor deposition.

Plastic or metal films are a few micrometers thick. The thickness of the vapor-deposited metal, glass or ceramic layers is in the sub-micrometre range.

We may be a composite chip consisting of two chips made of a metal foil and a plastic foil connected together. In this embodiment, the foil forms the inside or outside of the composite foil. In another embodiment, the composite film consists of two plastic films of different materials,

It is preferable for the three-ply composite film to contain two plastic films.

There is a metal foil between them, connecting the three foils together. Composite foil may contain, instead of metal foil, a layer of glass or ceramic, such as silicon oxide (SiOx), produced by vapor deposition on a plastic foil.

In another embodiment, the inner film of the composite film consists of a copolymer, eg an ethylene-acrylic acid copolymer. It is preferable that the outer plastic sheet of the composite film be made up of a plastic material, for example polyethylene terephthalate, whose melting temperature is higher than the melting temperature of the plastic material that makes up the inner sheet. This flows from the seam welding process of the plastic material that makes up the inner film in the film bag production process.

In a composite film, a bonding layer can be provided between the two films.

The foil bag may include a plastic film with a thickness ranging from 20 micrometers to 100 micrometers. It may also include a composite film consisting of an inner sheet of plastic material with a thickness ranging from 0.2 µm to 100 µm, and an outer sheet of metal with a thickness of between 8 µm and 20 µm. A foil bag may also include a composite film consisting of an inner sheet of plastic material with a thickness of between 0 and 100 micrometers, and a middle sheet of metal with a thickness of between 8

µm and 20 µm, and an outer sheet of plastic material with a thickness of between 0 and 1

µm and 0 4 µm.

The vessel according to the invention is described in greater detail by reference, for example, to the figures.

Figures 1 through 3 represent perspective drawings of various embodiments of the foil bag closed at both ends. Figure 1 shows a tubular bag 1 1 with a fixed, cylindrical flange 2 1 and a u-shaped transverse seam 3 1 closing one end of the tubular bag and extending at least partially in the longitudinal direction of the tubular bag. The edge 4 1 of the protruding flange connects with the other end of the tubular sac. A hole 5 1 is located on the axis of the protruding flange into which a drain connection member can be inserted.

Figure 2 shows a bag with a sealing edge 1 2 containing two films located one on top of the other. The bag contains two welded proteins 22 that extend in the longitudinal direction of the bag, and at one end, a welded seam 23 that extends in the transverse direction. The other end is connected to a fixed protruding flange 4 2 in a fish-like shape. A hole 5 2 is located in the center of the protruding flange through which a drainage connecting member can be inserted.

Figure 3 shows a bag with a side fold 31 that is folded at both its longitudinal sides, and closed at each end by a special welded seam 32 that extends transversely. The protruding flange 33 is welded to maintain the shape of the bag on its flat side. The drain connection portion can be inserted into the hole 34 in the protruding flange.

The protruding lip can be fixed in different shapes. If placed at the end of the foil bag as its sealing device, it can be of a rotationally symmetrical shape and can be adapted to the size of the end of the foil bag. The fixed-shaped protruding flange may be provided with a guide passage into which a drain connection portion can be inserted. When installing the vessel, the valve's connecting member is located in the guide passage.

In one embodiment, the guideway is provided with a piess fit device encircling the discharge coupling member. In one embodiment the bag coupling device is part of the guideway and has a smooth inner wall with an inner diameter that differs only slightly from the outer diameter of the drain coupling member. In another embodiment, a plurality of bulge portions may be provided in a portion of the guide passage on its inner wall. The swollen parts, for example, may have an elongated shape, bend symmetrically and expand in the axial direction. A plurality of bulging parts may also be provided, arranged at axial distances from each other and extending in the azimuthal direction, forming, for example, two rings or comprising a plurality of ring parts. In addition, the bulging parts can extend into a helical configuration; Whereas, it may contain a group of helical parts distributed on the inner wall of the guideway

Or it may contain a helical portion whose length is longer than the circumference of the guideway. It provides a means of pairing

By such pressing the vessel is mounted on the valve connecting member and a sufficiently stable coupling of the protruding flange with the valve connecting member may be provided. Moreover, after emptying, the vessel can be withdrawn from the connecting member for drainage without damaging the latter.

The protruding lip may be single-part or multi-part. The preferred multi-part cantilever flange is the multi-part cantilever flange. A neat, outward portion of the protruding flange connects to the foil bag in a leak-proof manner. The outer part contains an opening that closes with the inner part in a leak-proof manner. The two parts can be screwed together using a screwthread, or they can be connected together with a snap-action connection or ultrasonic welding. The shape of a single-part cantilever flange is similar to that of a two-part cantilever flange, but does not contain any connecting elements. The projecting flange may be manufactured at the same time as a snap coupling, groove for sealing location, and pierceable membrane.

The protruding lip may be made of rubber, metal or plastic, preferably a thermoplastic material. It may be desirable to make the protruding lip from the same plastic material used to form the foil bag or the inner side of the foil bag. A protruding flange made of rubber or metal material can be attached to the foil bag by gluing or possibly vulcanization.

Figures 4 to 7 show cross-sectional views of different embodiments of the cantilever flange. Figure 4 shows a view of a longitudinal section through a single-segment cantilever flange 1 4 containing a cylindrical guide passage of Figure 42, in the form of a bag coupling device, for a cylindrical drainage connection member. The outer end of the guideway is chamfered, while the other end is closed by a diaphragm 43 located diagonally with respect to the axis of the protruding flange. The protruding flange 1 4 is manufactured in one operation, and its edge is connected to a foil bag 4 4 .

Figure 5a shows a longitudinal section of a cylindrical multi-part cantilever flange, and Figure 5b shows a cross section taken along line 5-5 in Figure 5a. A lower portion 51 of the protruding lip is connected to a lamellar bag 53. An upper part 52 of the protruding flange is installed in a slot located in the lower part 051 and the upper part 52 is provided with a guide passage 54 which has three elongated protrusions 55, as shown in Figure 5b, extending in the axial direction of the protruding flange. The elongated prongs 55 serve as a snap-on coupling device for a drain coupling member. An annular protrusion 56 acts as a seal. The lower part 51 and the upper part 52 are welded together at their contact surface 57. The guideway 54 includes an entry hole with an inclined insertion surface. This entry hole is sealed with a sealant film 58.

Figure 6 shows a fixed-shape multi-part cylindrical cantilever flange. A lower portion 61 of the protruding lip is connected to a lamellar bag 63. The upper part 62 of the protruding lip protrudes into the lower annular part 1 6. In the upper part 62, a circular ring 4 6 acts as a seal and is held in place by a gland 65 that is pressed into place. The slot works in a loop

Grouting 65 as a guideway for a drain connecting member. On the inner side of the seal in the upper part 62 is a protrusion extending circumferentially 66, which provides a means of coupling to the bag. A drain coupling member 67 is inserted into the guide passage of the packing ring 65. The vessel is fixed on a drainage connection member 67 by means of coupling to the bag in the form of a protrusion that extends circumferentially 66. The lower part 1 6 and the upper part 2 6 are welded together at their contact surface 8 6.

Figure 7 shows another embodiment of a multi-part cantilever flange according to the present invention.

A lower portion 71 of the protruding flange is connected to a pouch 073 and an upper portion 72 of the protruding flange is located in the lower annular portion 71 with a shoulder. The upper portion 72 includes a flat ring 4 7 acting as a seal, which is held in position by a gasket ring 75 that is pressed into position. A guide passage 76 for a drainage coupling member is placed below the flat ring 074, and two protrusions 77 within the guide passage 76 form a means of coupling to the piston, extending around it in the form of threads. Near the lower end of the guideway 76 is provided a diaphragm 78 perpendicular to the axis of the protruding flange. The membrane 78 is pierced when the vessel is installed on the connecting member for drainage. The membrane 78 and the upper part 72 are manufactured in a single operation. The lower part 71 and the upper part 72 are connected together at their contact surface 79.

Figure 8a shows a cross-section view of a single-segment cantilever flange 81 that is fixed in shape as it lies on the side of a foil bag 82. The protruding flange 81 contains a guide passage 83 that serves as a compression coupling device for a drain coupling member. This protruding flange 81 is sealed at its outer end with a sealing film 084 and when the vessel is installed on a drain connection member 85 with a beveled end, the foil bag is pierced at the inner end 86 of the guideway 83.

Figure 8b shows a detailed view of a cross-section through a commercially available laminated three-ply laminated bag format. The inner foil 87 is composed of polyethylene (4.0 micrometer thick), and the middle foil 88 acts as an anti-diffusion barrier.

It consists of aluminum (1.2 micrometers thick) and the outer layer 89 is composed of polyethylene terephthalate (1.2 micrometers thick).

The welded seam at one or both ends of the foil bag can be V, U or T shaped. The seam runs substantially transverse to the axis of the bag. In one embodiment, the welded connection may extend partially in the direction of the bag axis, where the specific deformation of the laminated bag is enhanced when liquid is drawn from it.

A leak-proof location or spill-proof device may be provided within or at one end of the guideway. The seal location may include a ring located within a groove provided on the inner wall of the guideway. The ring may be circular in shape, or it may have a substantially rectangular cross-section. The ring may be provided with a sealing lip. The ring may be made of an elastomer, a thermoplastic rubber polymer, or rubber. The leak-proof location is attached to the filling space or vessel chamber mounted on the coupling member for drainage in order to prevent gas and liquid leakage from ambient air. In addition, the leak-proof location allows the vacuum vessel to be withdrawn from the coupling member for drainage. A sealing location is required if the sealing effect of the snap-in coupling device is insufficient.

The width of the welded seam on the foil bag may range from 0.7 mm (mm) to 3 mm. The width of the welded seams is chosen according to the requirements for complete sealing and seam durability. Wide and longitudinal seams can be made on the foil bag after the welding process, so that they are placed on the outside of the foil bag, so that the width of the foil bag is only slightly greater than its width in the non-welded part between the welded seams.

The welded seams on the foil bag and the welding site between the foil bag and the protruding flange are made by well-known processes such as heat welding, ultrasonic welding or induction welding in the case of composite foils with a metal layer, where it is preferable to press the welding sites in the heated state. We demonstrate such processes, for example, in two patents

European No. 131 111 0 and No. 239 130 0, as described in this statement in full for reference.

Figures 9a, 9b, 10 or 1b show cross-section views and side views of various embodiments of the welded seam with the foil bag closed at at least one end. Figures 11 or 11b show a side view and a step view of an alternative embodiment of a welded seam on the end of the bag.

Figure 9a shows a U-shaped welded seam 1 9 extending partially in the longitudinal direction of the laminated bag 92. At one side of the foil bag 92, the welded seam 91 merges with the welded seam 93 of the foil bag extending in the longitudinal direction. Figure 9b is a view of a cross section through the film bag taken along line 9-9 in Figure 9a. The inner layer of the multi-layer folded foil 4 9 is welded at the welded seams 91 and 93.

Figure 0 1a shows a V-shaped welded seam 1 0 1 extending partially in the longitudinal direction of the laminated bag 102. In this case, the laminated bag 2 0 1 consists of a tubular film without a longitudinal seam. Figure 1b shows a view of a cross section through the film bag taken along line 10-10 in Figure 10a. The single-layer folded sheet 103 is welded to the welded seam 101.

Figure 1 1a shows a side view of a welded T-shaped seam 1 11, while Figure 1 1b shows a line view of the welded end of the laminated bag 112. In general, the length of the three prongs of the T-seam 111 is the same as the width of the plywood bag, if folded flat, on the outside of the T-seam.

A foil bag welded with a V, U or T-shaped seam in the transverse seam area shall not be larger than the diameter of the shell into which the foil bag may be inserted.

The drainage site should preferably be in the form of a hole or a perforated site. A permeable membrane may be provided at the perforation or perforated site, where the membrane is pierced at

Installing the vessel on the connecting member for drainage. The membrane is preferably arranged between the sealing site and the fluid compartment or space in the laminar bag. The permeable membrane can be placed at one end or within the guideway. It is preferable to place it directly at the end of the guideway or close to this end, which is towards the fluid space. The membrane may be part of the labrum or part of the lamellar sac. If it is part of the flange, it can be made at the same time as the flange, and it can be made from the same plastic material as the flange. The permeable membrane serves as the original sealing device for the filling compartment or compartment in the bag

Lamellar.

In another embodiment, the drain location may be sealed with a sealant film that is pulled before installing the vessel on the drain connecting member or pierced when installing the vessel on the drain connecting member.

The container can be placed in a fixed-shaped feeder consisting of a metal or a plastic material. One end of the casing is connected to the protruding flange in a releasable or non-releasable manner, while the other end of the casing can be closed at the bottom. In one embodiment, the casing is substantially closed on all sides, but has at least one opening. Alternatively, a gap may be provided where the casing connects to the protruding flange. The cover may also be in the form of a fixed basket containing many openings. In an alternative embodiment, instead of the sleeve, the vessel may be placed in a fixed U-shaped holder, each prong of the U-shaped holder being securely attached to a protruding lip, the prong being longer than the foil bag.

In a preferred embodiment, the receptacle placed inside the casing is in contact with the casing itself only at the protruding flange. The end of the foil bag, which is sealed with a welded seam, or its two ends closed with two welded seams, are not in contact with the packaging.

When the liquid is transferred from the vessel to the connecting member for drainage, the film bag collapses flat under the influence of external pressure. The air passes through the hole in the cover or through

The gap between the wrapper and the protruding flange, into the space between the wrapper and the foil bag, ensures pressure equalization. Thus, no valve is needed in the foil bag and the liquid in the foil bag does not come into contact with the air.

A schematic diagram of making and filling the vessel according to the invention is shown in the perspective drawings of Figures 12a-12 and Zo13a-13f.

As shown in Figure 12a, a strip of folded foil containing a welded seam in the longitudinal direction is supplied at both ends, divided into parts and shaped to form a tube. The lower part of the two-part cylindrical flange, made by injection molding, is welded to one end of the tube, as shown in Figure 21b. The other end of the tube is welded with a U-shaped transverse seam, as shown in Figure 12c. The finished vessel is pushed into a cylindrical aluminum housing, as shown in Figure 21d, the edge of which is pressed into a groove or channel in the edge of the cylindrical protruding lip. This way the bowl fits firmly in the casing. The empty container placed in the casing is then filled with liquid through the lower part of the protruding lip equipped with an opening, as shown in Figure 2 1e. After completing the filling process, the upper part of the protruding lip is pressed inside the lower part, as shown in Figure 2 and 1f, and the two parts are connected together in a leak-proof manner. The finished part, as shown in Figure 12g, is ready for installation on a drain connection member.

An alternative manufacturing process is shown in Figures 31a-31f. One end of the pipe is connected to a single-segment protruding flange closed by a sealing film, as shown in Figure 31b. The vessel is filled with liquid through the other open end of the foil tube, as shown in Figure 31c. The open end of the laminated tube is closed by a U-shaped transverse suture, as shown in Figure 3 1d. The filled container is placed inside a plastic cover, as shown in Figure 31d. The edge of the plastic cover is fixed on

The edge of the lip is one-part, folded. The finished part, as shown in Figure 3 and 1, is ready for installation on a drain connection member.

Figure 4 1 shows a partial cross-section view of a typical vessel 141 according to the present invention filled with a fluid and placed in a metal feeder 142. The foil bag is welded at one end with a U-shaped seam, while at the other end it is welded with the edge 144 of the lower part 145 of a two-part, cylindrical protruding flange of fixed shape. The metal sleeve has a bottom 146 in which there is an opening through which air can pass into the space between the metal sleeve 142 and the foil bag. The open end of the metal sleeve 142 is pressed into a groove or channel 147 in the edge of the lower portion 45 1 of the protruding flange. The metal casing 42 1 is fixedly connected to the protruding flange. The upper part 148 of the protruding lip is installed in a hole in the lower part. 145 The lower part 145 and the upper part 148 are connected by a quick-acting closure 149 and are provided with a flat drinking straw 150. Routing lane 151 is closed at its inner end. Using a membrane 152 and sealed at its outer edge with a waterproof film 153.

The metal casing shown in Figure 41 is preferably made of aluminum.

In one embodiment, it has a length of 43 mm, an outer diameter of 1.7 mm, and a wall thickness of 0.5 mm. The two-part flange is made of polyethylene and is manufactured by injection molding process. The upper part of the protruding flange containing the membrane is preferably made in one step in the process. The guide passage at the top of the protruding flange has an internal diameter of 2.5 mm at the piston coupling location and is fixedly mounted on a drainage coupling member.

The foil bag is anti-diffusion for the medical liquid and its components and for gases. The film bag material and composite film structure are selected potentially appropriate for use with liquid. The term “anti-diffusion” according to the present invention refers to the loss of vessel fluid (as measured by ethanol at ambient temperature) due to diffusion

At a rate of less than 0.6 mg (milligrams) per day, preferably less than 0.4 mg per day, and especially preferably less than 0.2 mg per day, and specifically less than 0.1 mg per day.

The inner foil or inner side of the foil bag touches the liquid inserted into the bag.

The material chosen for this film is a material that is not affected by the liquid and does not affect the liquid in a harmful way. It is preferable that this foil be in the form of a weldable foil.

One of the films or a layer placed by vapor deposition, for example, is the anti-diffusion barrier. This barrier prevents the spread of the liquid or its components and prevents the spread of gases from or to the foil bag. It may be desirable to protect the anti-diffusion barrier from mechanical damage and from tearing when the film is bent. One method of protection is to place another plastic sheet on the anti-diffusion barrier so that the spread of liquid or gases continues to be prevented for a long time.

Because the foil bag is diffusion-proof for gases, the drop in pressure that occurs inside the foil bag due to the liquid draining from it cannot be compensated for by the diffusion of gas into it. Thus, the foil bag collapses reliably even if the liquid drains from the vessel very slowly. Also, the liquid can be withdrawn from the foil bag in large partial quantities, for example 200 measured amounts, distributed over a long period of time, for example three months.

The container placed inside a closed feeder shall be essentially impervious to the outside and shall not be damaged when stored or when installed on a connecting member for drainage. An intrinsically sealed cover, a basket-shaped cover with multiple holes, or a fixed shape catcher makes it easy to store the container containing the thin foil bag. These covers also facilitate its use when it is installed on the connecting member for draining and when pulling the empty container from the connecting member for draining.

An example of a discharge coupling member is the hollow plunger for a medical liquid atomizer. Such an atomizer is described in German Patent No. 902.5 36 195 and European Patent No. 2687 97/1, which are described in full herein for reference. An example of an atomizer is shown in Figures 6a and 6b in this description. The hollow piston in this vaporizer is in the form of a connecting member to drain the medicinal liquid inside the container according to the invention. The bowl is mounted on a hollow piston preferably placed on the axis of the atomizer. In this configuration, the hollow plunger tip fits into the drainage site and is thus immersed in the medicinal fluid. The leak-proof location of the protruding lip seals the contents of the container in a way that prevents them from drinking into the outer wall of the hollow piston. The piston coupling device fixes the bowl on the hollow piston mechanically quickly and sufficiently.

It may be desirable, instead of or in addition to the force-locking connection between the bowl and the valve's connecting member, to provide a releasable positive locking connection between the fixed-shaped flange of the bowl and the discharge device, for example an atomizer. Such a connection may be in the form of a push-in snap connection, comprising a set of snap hooks fitted to a connecting portion of the drain device. When the vessel is mounted on a drainer, the snap hooks engage with a slot in the protruding flange, such as with a notch extending circumferentially or beyond the edge of the protruding lip. It is preferable that the snap noses be round in shape or beveled in both directions of movement of the bowl, so that an empty bowl can be removed using a moderate amount of force, and a full bowl can be installed on the drain tool using a moderate amount of force.

Figures 15 or 5 1b show a positive, snap-in, releaseable spring connection located between the fixed-shaped protruding lip of the receptacle and the connecting portion of the drain device.

Figure 5 1a shows a cross-sectional view through a connecting portion 154 disposed in the drain device and including at its axis a drain connecting member 67. Surrounded by a group of

Snap hooks 155, snap heads 156 have a round cross-section, with a drainage connection member 67. The occlusal hooks 155 are separated from each other by an intermediate space

It has an azimuth width ranging from 1.0 degrees to 6.0 degrees. Part 57 1 may be provided no

It has any occlusal head between two occlusal hooks 155. Part 157 rests with a positive clamp on the outer wall of the permeable vessel.

Figure 5 1b shows a side view of the end of a vessel encased in a casing 142 with its fixed-shaped protruding flange 148 protruding out of the casing 142. As shown in Figure 4 1, the casing 142 has a notch extending circumferentially 158, preferably in the region of the portion of the protruding lip that protrudes into the casing 142. The snap heads 156 of the bowl are engaged when installed in the connecting part 154 with the groove 158, while the bowl is connected to the connecting part 154 in a releasable manner with a positive tension relationship.

Figures 61a and 61b show another embodiment of a positive snap-in, push-in, releaseable spring connection.

Figure 6 1a shows a cross-sectional view through a connecting portion 161 disposed in the drain device and including at its axis a drain connecting member 67. A set of snap hooks in the form of tabs 162, with snap heads 163 with beveled sides in both directions of movement of the vessel, surround the drain connection member 67. The snap hooks 162 are placed such that they are separated from each other by azimuthal spacing.

Figure 6 1b shows a side view of the end of a vessel placed in a casing 142 with its fixed-shaped protruding flange 148 protruding out of the casing 142. When the bowl is installed in the connecting portion 154, the occlusal heads 163 engage with the circumferentially extending notch 147 of the portion of the protruding flange 148 that protrudes outside the casing, while the bowl is in releasable contact with the connecting portion with a positive tension relationship.

The vessel according to the invention is particularly suitable as an interchangeable cartridge for inhalable drug solutions in propellant-free atomizers. The filling volume of the vessel may range from 0.5 ml (ml) to 5 ml, preferably from 1 ml to 4 ml, particularly from 1 ml to 3 ml or from 2 ml to 4 ml. These solutions are dispensed in portions, with the specific dose ranging from 1 microliter (μ1) to 5.0 microliters, and preferably from 15 microliters (μl) to 2 microliters.

The diameter of the shell may range from 1.0 mm (mm) to 3.0 mm, preferably from 1.2 mm to 1.7 mm. The length of the vessel, including the portion that protrudes beyond the casing for the fixed flange, may range from 2.0 mm to 6.0 mm, and preferably from 30 mm to 5.0 mm.

According to the invention, the vessel functions as a primary packaging means to contain a medical liquid containing, for example, a medicine dissolved in a solvent. Examples of suitable solvents include water, ethanol, or a mixture of both. Examples of medications used include Berotec (fenoterol-hydrobromide; 1-(3,5-dihydroxyphenyl)-2-[[1-(4-hydroxybenzyl)-ethyl]-amino]-ethanol-3,5-hydrobromide. )-a

dihydroxyphenyl)-2- [ [ 1 -(4-hydroxybenzyl)-ethyl]-amino]-ethanol-hydrobromide),

Ahtrovent (iprateopium bromide), Berodual (a combination of fenoterol-hydrobromide and ipratropium-bromide), Salbutamol (or Albuterol), Combivent, Oxivent (oxifropium bromide, Ba 679). (Bromide Tiotropium BEA 2108, (tioOpium bromide (di-(2-thienyl)-glycol acid tropenol ester), Flunisolid, Budesonid, Beclomethasone and other medicines.

International Patent Publication No. 27959/98 describes stable aqueous medicament preparations for producing gas-free aerosols for inhalation, which are described in full herein for reference. In particular, reference is made to the preparations mentioned in this statement and shown in examples.

For example, suitable pharmaceutical preparations in a solution of ethanol are shown in International Patent Publication No. 01329/97, the description of which is mentioned in this statement in full for reference. In particular, reference is made to the active substances specified in this statement (see pages 2 and 3) and the fixed preparations mentioned in this statement.