Denture cleansing tablet.

Description of the Reckitt GmbH German Industrial and Commercial Patent, headquartered at Hoffraannstrasse 6, D-4920 Bad Salzuflen, Federal Republic of Germany (inventor: Dr. Mira Reuss, residing in West Germany), for PRO ·· CD3S0 FOR PP.DP.aR. ·· 'Ç. ~ 0 DD A PA3TIL1IA

DD CLEANING DG DSXTA HARD¹¹

Description

The present invention relates to a cleaning pad for the automatic cleaning of aqueous solution dentures according to the preamble of the main claim.

Denture cleansing tablets, for example those of the type described in DE-OS 2133710; They are used by placing them in water at the same time as the denture is not cleaned, and then the cleaning tablet disintegrates with more or less pronounced gas development and releases active substances which attack and remove contaminant coatings. that adhere to the denture.

Such wipers, as they are the subject of German patents 2312847, 2543469,

2653450 and 2741072, European Patents 0010412, 0023005 and 0102418, as well as EP-OS 0133354, 0149308, 0157464 and 0255658, contain essentially oxygen-releasing substances for oxidation and disinfection (such as monopersulfates and / or perborates). , inorganic anionizers and calcium oxide binding agents (such as phosphates and / or polyphosphates), chelating agents such as EDTA, gas forming vehicles such as carbonates and / or

<img file="PT90035B_D0001.tif" />

bicarbonates, citric acid, tartaric acid, starch sulfonic acid or their disinfectant salts, such as alkyl benzoates and / or hydroxybenzoates, as well as binder and / or disintegrating lubricants, surfactants, colorants and lastly aromatic agents. As a function of the composition, when dl; 3ol is seen in water the ph values ​​fluctuate between neutral and alkaline acid. They are generally quick cleansing tablets, and have a cleaning time of 10 to 15 minutes. However, in certain cases they are slow acting tablets with relatively long periods of use, wherein the complete cleaning action with respect to the denture thus treated is only achieved after 1 to 2 hours. With regard to denture cleaning, all of the above tablets have a disadvantage that is characteristic of the composition and practice of use. Formation of axigen perborate in the desired active form by means of ion 1100 is only satisfactorily performed at temperatures above 60 ° C. However, dentures are generally cleaned by the user in about 10 to 15 minutes at approximately 30 to 40 ° C so that in the case of known cleansing tablets a considerable part of the intended oxidizing and disinfecting action of the oxygen releasing substances is not realized.

EP-Od 0253772 discloses a cleaning tablet of the aforementioned type wherein the phosphorus compound consists of a combination of phosphates which act or participate in the cleaning process while using a polymeric phosphoryl carbon as the binder. When using a hydrophobic florocarbon there is a problem with the dissolution of the wipe not only because the dissolution becomes more difficult due to its hydrophobic nature, but also because it floats in the dissolved cleaning liquid in the form of reagent separation and thus delays the release. cleaning action The use of such a polymeric hydrophobic binder explains why in the case of the Ef-Oo O253772 cleaning tablet₉high activator content is used between 5 ^The 15 / in weight, which leads to a loss of the actual subs2 content

<img file="PT90035B_D0002.tif" />

active, specific cleaning agents. As noted, in the known cleansing tablet, inorganic phosphates are also used, in the same way as the STD used to act: Such metal bonding agents cannot be considered perfect because of possible influences of the environment. The problem of the present invention is to provide a so-called quick cleansing tablet of the aforementioned type which, while ensuring the stability and activity of the tablet by a suitable process stabilizing agent, makes it unnecessary to use a hydrophobic non-ρε-iripeptate binder in the cleaning process or harmful inorganic polyphosphates as medium, EDTA / XTA and NL6.

According to iro seri lem veriç

This problem is achieved through the etheric chamber shown in the main chamber portion of the main claim. The achievements; Particularly preferred embodiments of the present invention form the subject matter of the subsequent claims.

^; The present invention is based on the surprising conclusion that it is possible to overcome the problems of the aforementioned known cleaning pads by using an organic phosphoric acid as a metal bonding agent and to stabilize the peroxide while avoiding the need of a hydrophobic polymeric binder. At the same time it is a stable hydrolysis removal agent, for example for eleal and heavy metals and also replaces problematic phosphates / polyphosphates as medium and EDTA, which have been the inorganic removal agents in the hitherto known cleaning agents. dentures, by dissolving the cleaning tablet the peroxide is not prevented by an inert polymer and is instead stabilized by a substance in the cleaning tablet, which upon dissolution in the cleaning process has the effect of removing the contact toxicants and analogs present in the water so as to keep the activator action in system method free from negative influences. According to the present invention it is only necessary to have an activator content of between 3.5 and 3.0) by weight, whereby it is possible to increase the percentage of active substances in the cleaning tablet. This is also possible in the tablet. In accordance with the present invention, because of the high activator activity, 5 to 10 parts of the polyphosphates commonly used in the prior art of the cleaning tablets may be replaced by only part of the phosphonates. Due to the peroxide and activator having a complete action on the cleaning liquid, without any foreign material for example in the form of floating hydrophobic polymers, it is ensured that throughout the cleaning period of for example 15 minutes and despite Slowly decreasing the temperature of the cleaning liquid in water or the like maintains the full activity of the peroxide. According to a preferred embodiment of the present invention, tetraacetyl acetylenediamine (T., b'D) is used as activator, which makes it possible to considerably increase and stabilize the release of active oxygen in the desired form for anti-oxidative action. microbe and cleaning by formation of high activity peracetic acid,

Phosphoric acids or their hydrolysis-stable salts used in the present invention have an enhanced binding action to calcium oxide, metal and in particular iron and simultaneously have a dispersing / deflecting action. Preferably proport. · It to the cleaning tablet one. dye system of the claimed type which enables optical labeling of the cleaning sequence to the end. of the main or total cleaning process. In this embodiment, during the cleaning process, there is a slight reduction in the color intensity, followed by a qualitative color change before discoloration occurs.

3rd characteristic of the cleaning pad

<img file="PT90035B_D0003.tif" />

According to the present invention there will be no inorganic phosphates, polyphosphates as a pre-organic organic removal agent based on amino carboxylic acids (e.g. EDTA). Anti antimicrobial and cleaning action is not sensitive to temperature within limits;

use, i.

It is intended to be used with an optical cleaning action within the range of approximately 2 ° C and 45 ° C._ç

As a result of the perborate activator used in the cleansing tablet according to the present invention, a reaction mechanism is initiated in the aqueous solution which can be represented as follows:

a) / 5₂O_gH,_!2-7. 2Na + -&gt; 2Na B0_P + 211^

Hydrogen Peroxide Perborate Monohydrate

b) H_O0_P + 0H {'&gt; H ^ 0 + H00_;) _ .. &lt;- C = 0 - H00-7

I *

CH „

0 -&gt; - X- C-OOH

I “3 acetyl activator group

Ο_d) C-OOH HO XK -r / "CH -C-OOH /?

0H_

CH, peracetic acid:

CH -8-0H + / "0_7 / *" ch „-c-ooh_7 acetic acid active axigen * important than peracetic acid if it is. me as an intermediate stage that decomposes, then, e: n acetic acid and oxygen. The release of the thus activated axigen from the perborate leads to significantly improved cleaning action.

The antimicrobial action of the cleansing tablet of the present invention achieved by the perborate / peroxide activator with peracetic acid as an intermediate stage also exceeds expectations. It is concluded that even in the case of high dilutions and short periods of action only sterility is obtained. The specific composition of the cleansing tablet may be varied in the manner known to the skilled artisan according to the desired purposes. In order to obtain bacterial-free cultures by foot incubation for 48 hours at a peracetic acid concentration of 0.002 to 0.005 / wt, it is sufficient to have an action time of between 2 and 10 minutes with respect to the test bacteria. (Escherichia coli, Staphylococcus aureus, Streptococcus mutans, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus mesenterius) in order to eliminate them. 0 same applies to hyphomycetes and blastomycetes (Trichophyton rubrum, Candida albicans). Even in cases of resistant enteroviruses, when using the cleansing tablet of the present invention, a much lower concentration is required due to the peracetic acid present than in the case previously used.

While the formulations of most known denture cleaning agents contain inorganic polyphosphates and phosphates for calcium oxide binding and dispersion as well as aminocarboxylic acid-based organic scavengers such as EDTA and NTA, the cleaning tablet according to The present invention does not require such additives. This is an advantage because polyphosphates are sensitive to hydrolysis, i.e. that is, they hydrolyze in aqueous solution accompanied by j) orthophosphate formation and as a consequence lose their dispersing action, while EDTA has no dispersing action from the outset. It should also be borne in mind that inorganic phosphates and, for example, EDTA are not perfect as a medium because the problems are caused by one of these due to the enrichment of oxygen-receiving plant water and the other due to difficult degradation. in.

In the case of the cleaning tablet according to the present invention the problem groups of products as means mentioned above are removed from the whole composition. The very effective calcium oxide and metal binding agents in the form of phosphonic acid-based organic removers or salts thereof first used in denture cleansing tablets according to the present invention are stable to hydrolysis, have an effective action. corrosion inhibitor and improve the cleaning process in which, in synergistic cooperation with the perborate activator, stabilize the release or oxygen releasing agent while having good dispersing and deflocculating properties.

Almost all known commercially available denture cleansing tablets prescribe hot and other water up to 5 ° C for the cleaning liquid. This is necessary with most conventional formulations in order to dissolve the peroxide active oxygen in good time. However, other disadvantages need to be accepted, eg faster hydrolysis, reduced dispersion / deflocculation, reduced corrosion inhibition, etc. -4 consequence of the action of actj. peroxide / stannilizer / stabilizer of the phosphonic acid-based hydrolysis-stable organic removal agent of the present invention, as well as the elimination of hydrolysis-sensitive polyphosphates ensure that the cleaning tablet of the present invention does not have the disadvantages mentioned, also completely effective. en; ambient temperatures and does not require hot water temperatures that have been required so far, so it is not necessary for the user to worry about disinfecting and cleaning action by not following the manufacturer's instructions for using heated cleaning liquid.

It has also not been possible so far with known wipers to sensorially or visually control the sequence and end of the wiping process. an intermediate stage of pre-cleaning, while the end of the main cleaning and last cleaning is not visible to the user of the tablet colors (e.g. blue, pink) used so far are visible for a long time after the washing process when using glass containers, even if another effect is really desired.

However, by using the dye system proposed in the present invention, the problems encountered hitherto with regard to the optical observation of the cleaning process can be eliminated. This involves the use of a reduction sensitive dye with a relatively low oxidation potential combined with a different color dye independent of the redox potential. Protons released by the oxidation of the contaminants and some proton release from the other pellet substances lead to a quantitative reduction in intensity. dye density, followed by a qualitative change in color before discoloration occurs. The time sequence is dependent on the degree of contamination of the denture as well as, in part, on the temperature and pH value of the mare. 2 It is possible to visually follow, in virtually all cases, the end of the main cleaning phase by the color change and the end of the cleaning process optimized for the desired action time for complete discoloration. This may be accomplished according to the present invention by different suitable color systems and when using the present combination with indigotine disulfonic acid disodium salt and quinophthalone disulfonic acid disodium salt a turquoise green color is obtained, h the color intensity decreases during the cleaning process and then changes to a greenish yellow (end of main cleaning) before discoloration (end of cleaning) occurs'.

The cleaning tablet of the present invention may be presented within the following limits:

<td>sodium perborate monohydrate</td><td>15-30 / by weight</td>

<td>potassium mono per sulfate</td><td>20-40O / W by weight</td>

<td>sodium hydrogen carbonate</td><td>10-30, - by weight</td>

<td>sodium carbonate</td><td>0-10- by weight</td>

<td>sodium sulfate</td><td>0-10 / by weight</td>

citric acid or salts of citrate and other similarly acting organic acids or their respective salts tetraacetyl ethylenediamine and other peroxides of action

5-20 / by weight

0.3-3 / wt similar organic phosphoric acid or polyethylene 20 silicon polyvinylpyrrolidone dioxide (respective aerosyl salts 0.5-3 / wt 1-4.5 / wt 0-3 / wt

200/300) 0.5-1.5 / wt sodium dodecyl benzene sulfonate ricinyl monoethanoyl sulfosuccinate

0.2-1 „5 / en: weight of sodium salt or hard acting triglyceride surfactants 0-2 / en: weight fatty alcohol polyglycol ethers 0.5-2 / by weight preservatives / stabilizers 0 -2p by weight

Peppermint powder or other flavoring substances (eg eucalyptus) 1-2 wt.

<img file="PT90035B_D0004.tif" />

J

<img file="PT90035B_D0005.tif" />

dye tank (for example indigotim L -... zul 2 and 0.05-0 quinoline yellow L-tidal mass 3 according to specific specification:

30 / J by weight

20Q in paso

20% by weight

<td>5% in</td><td>Weight</td>

<td>4% in</td><td>Weight</td>

<td>7% in</td><td>Weight</td>

<td> 10 5°°</td><td>by weight</td>

<td>1 · 5b</td><td>by weight</td>

4 wt% 1.5 wt%

1 ', 5b · en; weight 0.75 /&gt; by weight 0o5b by weight

1% by weight

1; by weight 5% by weight

O2p% by weight

The following is a lemon tablet of the present invention for a sodium perborate monohydrate potassium monopersulfate sodium hydrogen carbonate sodium carbonate sodium sulfate citric acid, sodium tetraacetyl ethylenediamine sodium salt or salts thereof polyethylene glycol 20,000 polyvinylpyrrolidone

Aeros il 200/300 sodium dodecyl benzene sulfonate hard triglycerides fatty alcohol polyglycol ether with peppermint powder

L-blue 2 indigotine and L-yellow 3 quinoline yellow

The above constituents were compressed into powder or granules using known methods to form a cleaning tablet. After dissolution, the resulting cleaning tablet has a pH value of

<td>at the</td><td>liquid</td><td>in</td><td>9 · θ cleaning</td><td>with temperature</td><td colspan="2">this last one</td>

<td>in</td><td>at 0 ° pv '-' O ±</td><td>Hi</td><td>possible to follow</td><td>visuahueiite the</td><td>course</td><td>of ρr the CO d so</td>

<td>in</td><td>cleaning</td><td>powder</td><td colspan="2">r a corresponding change of</td><td>color and</td><td>and 3 t OVH con</td>

after about 10 minutes.