Apparatus for producing of prescription formulations

ARCHIVE COPYRIGHT

REPUBLIC

POLAND

<img file="PL63165Y1_D0001.tif" />

Patent Office of the Republic of Poland (12) PROTECTIVE DESCRIPTION OF THE DESIGN (21) Application number: 114934 (22) Date of application: 09.07.2004 (19) PL ni) 63165 (13) Y1 (51) IntCI.

B01F 11/00 (2006.01) B01F 7/16 (2006.01) B01F 7/22 (2006.01) (54) (30) Priority:

Equipment for the production of prescription mixtures (73) Authorized with the right of protection:

26.05.2004, DE 202004008573.9

Konietzko Albrecht, Bamberg, DE (43) The notification was announced:

28.11.2005 BUP 24/05 (72) Creator (s) of the utility model:

Albrecht Konietzko, Bamberg, DE (45) The following protection rights were announced:

31.05.2007 WUP 05/07&gt;

CO &lt;0

WHAT

about.

P &amp; 5S5

A device for producing recipe mixtures

This solution applies to the device for the production of prescription mixtures, especially for making ointments, pasty or liquid substances mainly for the pharmaceutical and cosmetics industries.

From EP 0 920 907 B1, a cylinder-shaped mixing and dosing container is known for the production of pharmaceutical, cosmetic or similar products and which has a lockable outlet nozzle from the bottom. Opposite the bottom, the open end is intended to grip the movable piston in the container body. The piston serves both as a guide for the drive shaft of the mixer and as an element of the dispensing mechanism of the rotary dispensing organ.

After the mixing process, the mixer shaft is disconnected from the mixer and removed from the container by means of a guide piston. Then, to collect the product, a dosing unit equipped with a spindle with a thread connected to the piston is placed on the container. By rotating the spindle, the piston moves towards the outlet nozzle, thus enabling dispensing.

The described dispensing principle is expensive and does not allow any simplification, since in each case the prepared formula mix requires a separate dispensing unit.

A container for storing pastes or liquids is known, for example, from EP 1 038 796 A2. The body of this container contains a movable dock that divides its interior into a pressure chamber and a tightly separated storage chamber. In order to dispense the product, compressed air is introduced into the pressure chamber and as a result of the piston displacement towards the storage chamber, mass is expelled from the outlet opening. The product dispensing principle described here is also relatively expensive. The product must be supplied with a compressed air supply for dispensing the product.

In turn, a mixing device is known from DE 197 35 539 A1, the agitator of which is in the container is always ready for use. For this reason, they must be adjusted to each other in terms of dimensions: the vessel, agitator and the drive end of the agitator rod so that the agitator is disassembled while the rod is entering the container from its initial position and after its return to its initial position it is immobilized. To obtain good mixing results a relatively long working time is required for this type of device.

A mixing device for mixing pharmaceutical and / or cosmetic products is also known from DE 42 16 252 C2, namely: ointments, pastes, creams, gels or emulsions. Good mixing results can also be achieved with this device. However, the mixing process itself is time consuming.

The task set before this solution is to develop a device for the production of recipe mixtures, which, despite the shortening of the mixing process, leads to a significant improvement in the quality of the manufactured product. In addition, receipt of the final product is greatly simplified.

The advantage of the device according to the utility model is primarily that the container and the stirrer are properly tuned together, so that the necessary friction contact between the mixing container and the stirrer itself leads to the quality of the right recipe by ensuring the efficient introduction of ingredients between the container a stirrer, which allows you to achieve the optimal mix with different recipe ingredients in a short time.

Compared to previously known solutions, a qualitatively better mixing result can be obtained with the aid of the present device, while reducing the production time.

In a particularly preferred embodiment of the device, the agitator is equipped with two paddle mixing arms connected to it in an overlap towards the axis of the drive shaft. The agitator arms are made as flat surfaces tapering towards the leading edge and have an oval shape in the plane of rotation. Each agitator arm is equipped with a recess or a hole in each case. The outer surfaces of the paddle blade arms facing the lid or the bottom of the container are so inclined in the front outer areas located in the direction of rotation that the thickness of the paddles decreases towards the edge of the stirrer. However, the subsequent surfaces of the paddle blade arms in the direction of rotation located on the opposite side of the through recess are so inclined that the thickness of the paddles decreases in the recess direction. Due to this shape of the stirrer, particularly good mixing of the ingredients of the recipe mix is ​​achieved. The external blade surfaces of the agitator arms facing towards the lid or the bottom of the container are intended to introduce material during the mixing process between the agitator and the immediate vicinity of the container, i.e. the lid or bottom. The subsequent surfaces of the agitator shoulder blades cause, by means of orthogonal arcuate areas, extending from the main planes of the agitator arms relative to the opposite internal surfaces of the container, the desired introduction of material.

During the mixing process, these obliquely located areas of the agitator surface produce suitable streams that lead to very strong swirling of the mix.

The agitator surfaces widened near the drive shaft affect the mixture being sucked around the center of the mixer and evenly moving portions of the mix towards the axis of the drive shaft. In this way, the concentration of the sliding force created in the center, acting on the mix, optimizes the inflow of the material input through the stirrer relative to the opposite areas of the inner walls of the container. At the same time, these enlarged surfaces weaken the undesirable air bubbles that appear in the product.

The through-recess in the agitator arm allows, on the one hand, the agitator end areas also in production and technical conditions to maintain production tolerance in the container by flexibly giving in and reversing in close contact with the inner wall of the container, and on the other hand, it is ensured that the expansion function equally effectively works on the introduced mixture. By adhering flexibly to the inner walls of the mixing container, an even run of the mixer in the container is achieved. While the arch-shaped end areas at the time of parking adhere elastically to the inner wall of the container, due to the pressure of the introduced material they move back elastically.

The reduction of the agitator blades towards its edges leads to a significant reduction in the energy required to drive the agitator. Due to the symmetrical design of the stirrer, it is possible to reduce the occurrence of noisy swinging of the mixer working at high revolutions in relation to asymmetrically made mixers. There is a significant reduction in the level of work noise during recipe production, which, for example, is very beneficial in pharmacies, as this should not interfere with conversations with customers.

According to a preferred embodiment, the surfaces of the agitator shoulder blades facing the lid or the bottom of the container are adapted to the shape of the inner surface of the lid or the inner wall of the bottom. Due to this configuration, an even feed introduction between the end area of ​​the mixer and the container wall is achieved.

In another embodiment of the mixer, its container has a sliding bottom. The sliding bottom is used to receive the mixture. The repeated opening of the lid for collection and the subsequent homogenisation of the mix can thus be effectively reduced. By means of a sliding bottom, it is possible to obtain volume equalization before the mixing process if the quantity of mix is ​​present than the volume of the mixing container. At the same time, this effectively displaces the air from the vessel.

Preferably a threaded bubble is used as the container, with the body being made in the shape of a cylindrical bubble provided with an external thread on which the lid is screwed. The threaded bubble also has a sliding bottom, the outer edge of which goes into a slip ring. The threaded bubble also has a bottom with a hole with an inner ring that serves as a stop collar for the sliding bottom. The threaded bubble also serves as a dispensing vessel, which can reduce the overflow of the produced mixture.

Cups have long been used in pharmacies as practical containers for storing or dispensing ointments, preferably in the field of prescription mixtures. Currently, bubbles are made of plastics with a capacity of 10, 20, 30, 50, 75, 10,150, 200, 250, 300, 500 or 1000 ml. Blisters as a medicine packaging for hygienic reasons are only dispensed once and cannot be returned or refilled. Thus, they are one-way containers, which are especially recommended for use as preparatory containers.

Mixing of the recipe ingredients in a closed system takes place without an air supply. Transferring the finished recipe from a large container to smaller dispensing containers is not required, since the large container also serves as a dispensing container.

Two forms are recommended for mixing containers. In a first embodiment, the mixing container lid is provided with a central hole for introducing the drive shaft. In this case, the central opening also serves as a receiving opening. In a second embodiment, the container includes a central opening for servicing the drive shaft if it is provided with a sliding bottom. In this version it is necessary to equip the device with an additional, closed receiving hole in the cover. In other embodiments, various adapters and applicators can be attached to the dispensing opening. Thanks to this, the product can be dosed better or it can be inserted more precisely into the body opening.

The formula is shown in more detail in the examples of the drawing, in which:

• Fig. 1 shows the container with the stirrer in a first embodiment in a simplified longitudinal section, • Fig. 2 the container with the stirrer in a second embodiment in a simplified longitudinal section, • Fig. 3 with the cross section of the mixer in a top view, • Fig. 4 bottom view of the agitator, • Fig. 5 inside the container in cross section during the mixing process, • Fig. 6 inside the container in longitudinal section during the mixing process • Fig. 7 detail of the end area of ​​the agitator arm when it adheres to the second inner surface delimiting the container, • Fig. 8 detail of the end area of ​​the agitator arm when it adheres to the inner wall of the container.

In Fig. 1 the container_l is simplified. with stirrer 2. Container _1_ is a cylindrical shaped threaded bubble. In the bottom of the container _ £ there is an opening _3, in which the limiter in the form of an inner ring is made. Inside the container

1 there is a sliding bottom. The sliding bottom 5 has on its outer edge a slip ring (not shown) acting as a seal. The bottom j can be moved up easily through the opening j in the same bottom 5. Its outer edge seals the inner wall 7 of the bulb.

The upper area of ​​the banks is provided with an external thread. A cover is screwed onto this external thread, the edge of which includes an internal thread. The cover j has a central opening 11 which is closed with a plug 13 if the stirrer_2 has been removed from the container 1. The central opening 11 simultaneously serves as a collecting opening for the finished product. The cylindrical space intended for the mixing process extends between the lower inner surface 6 and the upper inner surface &lt;8. The agitator j is attached to the end of the drive shaft 15 and secured against disconnection. The drive shaft 15 is rotated into the container through the central hole vv. The drive shaft 15 is in turn connected to the other end with a variable speed electric motor (not shown) that closes the drive system. Cooperating drive and clutch components are connected in a known manner.

It is important that the drive shaft 15 and agitator 2 are permanently or releasably connected to each other. In a specific embodiment, the stirrer 2 is made as a lost element and remains in the mixing container after the mixing process. In this case, the bubble must remain closed, because only the drive shaft must be removed from the central hole.

In the second embodiment, shown in Fig. 2, the container A is shown as a rotary cylinder with a sliding bottom inserted therein. The sliding bottom 5 can be removed from the container and during filling with the recipe ingredients. The central hole 11 is located in the sliding bottom 5. A drive shaft 15 is guided in the central hole U. at the end of which a stirrer 2 is mounted. On the steep container J_ opposite the sliding bottom. 5. a receiving hole 19 is arranged, closed by plug 13.

Figures 3 and 4 show a paddle mixer 2 consisting of two arms 21. 23 connected to each other and staggered in the axial direction of the drive shaft 15, which in the area of ​​the shaft 15 are overlapped. Shoulder blades 21. 23 are made as flat plates, tapering towards their ends, while in the plane of rotation they comprise substantially oval surfaces provided with through holes or recesses 25. On the other hand, the sides of the mixer 2 facing each other, in the direction of rotation, are inclined in the front region 27 of the recess 25 towards the plane of the shoulder of the second arm and narrowing towards the outer edge, while those sides of the mixer arms 2 that face each other - also in accordance with with the direction of rotation, they are inclined at the rear area 29 of the recess 25 towards the plane of the shoulder of the second arm and narrow towards their inner edges.

The end regions 31 with the arch-shaped shoulder blades 21, 23 flexibly adhere to the inner wall _7 of the container _1.

The surfaces of the arms 21 facing towards the lid 9 ^ or the bottom j5 of the container J 23. The agitators 2 are adapted to the inner surfaces 6, fi of the lid 9. or the bottom 5. Thus, a more intense introduction of material 33 between the inner surfaces 7 and the stirrer ^ can be achieved.

Both arms 21. 23 of the agitator 2 are provided with areas 27. 29. The areas 27 move the input material 33 between the agitator _2 and the container portion X adjacent the axial direction with the drive shaft 15 during the mixing process. Depending on the design of the container 1, i.e. depending on whether the drive shaft 15 is introduced into the container X through the bottom 5 or through the cover _9 - it can be either one or the other. The areas 29 affect in this case the input material 33 for the container L opposite the lying inner surface _7. Before the actual mixing process, displacement of the bottom of the container is possible as much air as possible from the container X (cf. the sliding arrows in Figures 1 and 2). By this treatment, the accumulation of air particles and their oxidation are largely removed. The mixing process starts with small revolutions, which increase continuously to the optimum number of revolutions, especially with ointments with solid ingredients depending on the size of the container and. The appropriate revolutions are generally between 500 and 1200 revolutions per minute in the initial phase, up to 3000 rpm to complete the process. The direction of rotation is shown in Figures 3 and 4 by means of round arrows.

In the economical and simple embodiment of the stirrer 2, manual guiding of the container X by means of an oscillating movement is used. With improved mixers, the container is automatically guided with the help of a stroke unit in a fixed rhythm up and down. A similar effect also arises if the stirrer _2 is run up and down with the container immobilized. 1,

After the mixing process is completed, the drive shaft 15 with the stirrer 2 is removed and before the next mixing process it is cleaned by pouring with a hot stream of water or simply wiping with cellulose. To reduce cleaning costs, it is also possible to separate the agitator 2 from the drive shaft 15 to clean them separately, while the relatively cheaper agitator 2 either remains in the mixing vessel 1 or is removed and discarded. Central bore 11. it is preferably closed with a plug 13 attached to the container L

When collecting the product, the plug 13 is removed from the central opening 11 or the receiving opening 19. Preferably, the removal or dispensing of the product can be carried out by simply moving the bottom 15 with the user's hand. Appropriate applicators are used for tight application with small or large holes in the body. These applicators regulate the amount of product secreted and allow for economical and reliable dosing.

In mixers, which have a large diameter and are very high, when the sliding bottom cannot be moved with the thumb of the operating finger, a pumping mechanism or a rotary mechanism is used as a metering aid. Such help also facilitates the transfer of the back-up product to small receiving containers with the dimensions given for the types of containers described above. If, before, the bottom of the dispensing container was moved close to the lid and with the help of the connector both receiving holes were coupled together, the inner wall assembly _7, perpendicular to the direction of the main plane of the agitator ^ could be during the whole mixing process.

Fig. 7 shows in detail the end area 31 of the stirrer _2 while it adheres to the upper inner surface 8_tThe material 33 is introduced between the stirrer 2 and the upper inner surface 8 of the container X when the stirrer 2 is in the highest position. In addition, Fig. 7 shows the effect of introducing material on the dispersion of already introduced and consolidated material 35.

In turn, the end region 31 with the arched blade of the stirrer 2 shown in FIG. 8 flexibly adheres to the areas of the inner wall pojemnika_ of the container _ during standstill. On the other hand, due to the pressure of the input material 33, the agitator 2 moves back elastically and thus allows the outside material to be introduced.

Proxy:

PATENT OBJECTS inż Χ ^ ιβΓΒόάοηβΓκ ^ // ł / 934