Device for the transdermal administration of a rotigotine base
Abstract
The invention relates to a polymer matrix suitable for the transdermal administration of rotigotine [(-)-5, 6, 7, 8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphtol], containing a matrix for the transdermal administration of rotigotine [(-)-5, 6, 7, 8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1naphtol], containing a matrix polymer which is supersaturated with a rotigotine base. Said polymer matrix is characterised in that the part of the rotigotine which is not dissolved in the matrix polymer is dispersed in the matrix polymer as amorphous particles having a maximum mean diameter of 30 ñm, and the matrix is free of solubilisers, crystallisation inhibitors and dispersants. The invention also relates to a flat device for the transdermal administration of rotigotine, containing the above-mentioned, preferably silicon-based polymer matrix which is supersaturated with rotigotine, and a rear layer which is impermeable to the active ingredient.
Term
No projected expiry on record.
- Priority
- Filed
- Published
- Today
40 members in 24 offices
Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 10261696 | Germany | A | |
| 10261696 | Germany | A | |
| 102616965 | – | – | – |
| DE2002161696 | – | – | – |
Members40
| Document | Office | Kind | |
|---|---|---|---|
| CA2485656A1 | Canada | A1 | |
| DE10261696A1 | Germany | A1 | |
| WO2004058247A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AU2003294007A1 | Australia | A1 | |
| EP1490052A1 | European Patent Office (EPO) | A1 | |
| BR0311637A | Brazil | A | |
| MXPA04012151A | Mexico | A | |
| NO20053202D0 | Norway | D0 | |
| US2005175678A1 | United States of America | A1 | |
| KR20050086373A | Republic of Korea | A | |
| ZA200408523B | South Africa | B | |
| NO20053202L | Norway | L | |
| IL165131A0 | Israel | A0 | |
| IL165131D0 | Israel | D0 | |
| CN1731995A | China | A | |
| PL378243A1This record | Poland | A1 | |
| JP2006513195A | Japan | A | |
| HK1088227A1 | Hong Kong, China | A1 | |
| NZ536235A | New Zealand | A | |
| RU2005124166A | Russian Federation | A | |
| AU2003294007B2 | Australia | B2 | |
| EP1490052B1 | European Patent Office (EPO) | B1 | |
| AT363274T | Austria | T | |
| ATE363274T1 | Austria | T1 | |
| DE50307373D1 | Germany | D1 | |
| PT1490052E | Portugal | E | |
| DK1490052T3 | Denmark | T3 | |
| SI1490052T1 | Slovenia | T1 | |
| ES2285234T3 | Spain | T3 | |
| RU2340339C2 | Russian Federation | C2 | |
| KR100875532B1 | Republic of Korea | B1 | |
| CA2485656C | Canada | C | |
| CN1731995B | China | B | |
| IL165131A | Israel | A | |
| US2011165247A1 | United States of America | A1 | |
| JP5134187B2 | Japan | B2 | |
| CY1108084T1 | Cyprus | T1 | |
| US8545872B2 | United States of America | B2 | |
| PL215307B1 | Poland | B1 | |
| NO335200B1 | Norway | B1 |
Numbers
- Publication
- 378243
- Publication, DOCDB
- 378243
- Publication, EPODOC
- PL378243
- Application
- 378243
- Application, DOCDB
- 37824303
- Application, EPODOC
- PL20030378243
Titles2
- English
- DEVICE FOR THE TRANSDERMAL ADMINISTRATION OF A ROTIGOTINE BASE
- Polish
- Urządzenie do poprzezskórnego aplikowania zasady rotigotyny
Classification
- CPC, 6
- A61K9/7069
- A61K9/70
- A61K31/381
- A61P25/14
- A61P25/16
- A61P25/24
- IPC, 2
- A61K31 381
- A61K9 70