Adamantyl acetamides as 11-beta hydroxysteroid dehydrogenase inhibitors
Abstract
N-oxide forms, pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein n is an integer of 1 or 2; R1 and R2 are each independently hydrogen, C1-4alkyl, NR9R10, C3-6alkyloxy; or R1 and R2 together with the carbon atom to which they are attached form C3-6cycloalkyl; and wherein n is 2, or R1 or R2 may be absent to give an unsaturation; R3 is C6-12cycloalkyl, preferably selected from cylooctanyl and cyclohexyl, or R3 is a monovalent radical having one of the following formulas, said C6-12cycloalkyl or monovalent radical being optionally substituted by one, or where possible two, three or more substituents selected from the group consisting of C1-4alkyl, C1-4alkyloxy, halogen or hydroxyl; Q is Het1 or Ar2 wherein said C3-8cycloalkyl, Het1 or Ar2 are optionally substituted with one or where possible two or more substituents selected from halogen, C1-4alkyl, C1-4alkyloxy, hydroxy, nitro, NR5R6, C1 -4alkyloxy substituted with one or where possible two, three or more substituents each independently selected from hydroxycarbonyl, Het2 and NR7R8, and C1-4alkyl substituted with one or where possible two or three halogen atoms, preferably trifluoromethyl; R5 and R6 are each independently hydrogen, C1-4alkyl, or C1-4alkyl substituted with phenyl; R1 and R8 are each independently hydrogen or C1-4alkyl; R9 and R10 are each independently hydrogen, C1-4alkyl or C1-4alkyloxycarbonyl; L is C1-4alkyl; Het1 is a heterocycle selected from pyridinyl, thiophenyl, or 1,3-benzodioxolyl; Het2 is piperidinyl, pyrrolidinyl or morpholinyl; Ar2 is phenyl, naphthyl or indenyl.
Term
Term ended
Projected expiry passed 16 December 2023, 2.8 years ago.
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39 members in 19 offices
Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 0214832 | European Patent Office (EPO) | W | |
| 0214832 | European Patent Office (EPO) | W | |
| PCTEP0214832 | – | – | – |
| WO2002EP14832 | – | – | – |
Members39
| Document | Office | Kind | |
|---|---|---|---|
| CA2508621A1 | Canada | A1 | |
| WO2004056744A1 | World Intellectual Property Organization (WIPO) | A1 | |
| WO2004056745A2 | World Intellectual Property Organization (WIPO) | A2 | |
| AU2003299243A1 | Australia | A1 | |
| WO2004056745A3 | World Intellectual Property Organization (WIPO) | A3 | |
| NO20053596L | Norway | L | |
| MXPA05006852A | Mexico | A | |
| KR20050088170A | Republic of Korea | A | |
| EP1581476A2 | European Patent Office (EPO) | A2 | |
| BR0317716A | Brazil | A | |
| EA200501045A1 | Eurasian Patent Organization (EAPO) | A1 | |
| CN1729158A | China | A | |
| PL377501A1This record | Poland | A1 | |
| JP2006511570A | Japan | A | |
| US2006079506A1 | United States of America | A1 | |
| HRP20050555A2 | Croatia | A2 | |
| HK1086552A1 | Hong Kong, China | A1 | |
| CN1915964A | China | A | |
| IL169315A0 | Israel | A0 | |
| HK1103716A1 | Hong Kong, China | A1 | |
| US7332524B2 | United States of America | B2 | |
| EA009710B1 | Eurasian Patent Organization (EAPO) | B1 | |
| US2008096869A1 | United States of America | A1 | |
| NZ541037A | New Zealand | A | |
| CN100450994C | China | C | |
| UA86755C2 | Ukraine | C2 | |
| AU2003299243B2 | Australia | B2 | |
| AU2003299243B9 | Australia | B9 | |
| CN1729158B | China | B | |
| US7968601B2 | United States of America | B2 | |
| KR101076751B1 | Republic of Korea | B1 | |
| NO331456B1 | Norway | B1 | |
| PL210615B1 | Poland | B1 | |
| JP4919599B2 | Japan | B2 | |
| IL169315A | Israel | A | |
| CA2508621C | Canada | C | |
| EP1581476B1 | European Patent Office (EPO) | B1 | |
| ES2614627T3 | Spain | T3 | |
| HRP20050555B1 | Croatia | B1 |
Numbers
- Publication
- 377501
- Publication, DOCDB
- 377501
- Publication, EPODOC
- PL377501
- Application
- 377501
- Application, DOCDB
- 37750103
- Application, EPODOC
- PL20030377501
Titles2
- English
- ADAMANTYL ACETAMIDES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS
- Polish
- Adamantyloacetamidy jako inhibitory dehydrogenazy 11-beta hydroksysteroidowej
Classification
- CPC, 61
- C07C233/11
- C07D207/27
- C07C233/14
- C07C233/22
- C07C233/23
- C07C233/32
- C07C233/41
- C07C233/58
- C07C235/36
- C07C235/40
- C07C237/20
- C07C237/22
- C07C255/41
- C07C255/57
- C07C271/22
- C07D209/08
- C07D209/18
- C07D213/56
- C07D215/08
- C07D215/48
- C07D217/06
- C07D217/26
- C07D243/08
- C07D257/04
- C07D277/40
- C07D277/48
- C07D295/088
- C07D295/155
- C07D295/185
- C07D309/12
- C07D311/58
- C07D311/64
- C07D317/60
- C07D317/72
- C07D333/24
- C07D333/68
- C07D335/06
- C07C2601/02
- C07C2601/14
- C07C2601/18
- C07C2601/20
- C07C2602/06
- C07C2602/08
- C07C2602/10
- C07C2602/12
- C07C2602/18
- C07C2602/42
- C07C2602/46
- C07C2603/62
- C07C2603/66
- C07C2603/70
- C07C2603/74
- A61P19/10
- A61P25/28
- A61P27/06
- A61P3/10
- A61P3/04
- A61P43/00
- A61P5/38
- A61P5/46
- A61K31/165
- IPC, 46
- C07C233 11
- A61K31 165
- A61K31 335
- A61K31 40
- A61K31 44
- A61P3 04
- A61P3 10
- C07C233 14
- C07C233 22
- C07C233 23
- C07C233 32
- C07C233 41
- C07C233 58
- C07C235 36
- C07C235 40
- C07C237 20
- C07C237 22
- C07C255 41
- C07C255 57
- C07C271 22
- C07D207 12
- C07D207 26
- C07D207 27
- C07D209 08
- C07D209 18
- C07D213 56
- C07D215 08
- C07D215 48
- C07D217 06
- C07D217 26
- C07D243 08
- C07D257 04
- C07D277 40
- C07D277 48
- C07D295 088
- C07D295 092
- C07D295 155
- C07D295 185
- C07D309 12
- C07D311 58
- C07D311 64
- C07D317 60
- C07D317 72
- C07D333 24
- C07D333 68
- C07D335 06