Interferon gamma polypeptide variants
Abstract
The present invention relates to novel interferon gamma polypeptide variants having interferon gamma (IFNG) activity, methods for their preparation, pharmaceutical compositions comprising the polypeptide variants and their use in the treatment of diseases, in particular for the treatment of interstitial pulmonary diseases, such as idiopathic pulmonary fibrosis. These novel polypeptide variants all comprise the substitution S99T as compared to the amino acid sequence of huIFNG or fragments thereof. By performing this mutation the naturally occurring N-glycosylation site present at position 97 is significantly beter utilized. Preferably, the variants comprise further modifications, e.g. in order to increase the AUC of such variatns when administered subcutaneously.
Term
Term ended
Projected expiry passed 4 April 2022, 4.5 years ago.
- Priority
- Filed
- Published
- Projected expiry
- Today
12 priority claims, no other members on record
Priority claims12
| Document | Office | Kind | Date |
|---|---|---|---|
| PA200100579 | Denmark | A | |
| PA200100579 | Denmark | A | |
| PA200100714 | Denmark | A | |
| PA200100714 | Denmark | A | |
| PA200200198 | Denmark | A | |
| PA200200198 | Denmark | A | |
| 01200100579 | – | – | – |
| 01200100714 | – | – | – |
| 02200200198 | – | – | – |
| DKPA200100579 | – | – | – |
| DKPA200100714 | – | – | – |
| DKPA200200198 | – | – | – |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)REFS | REFS |
Numbers
- Publication, DOCDB
- 366705
- Publication, EPODOC
- PL366705
- Application
- 2366705
- Application, DOCDB
- 36670502
- Application, EPODOC
- PL20020366705
Titles2
- English
- INTERFERON GAMMA POLYPEPTIDE VARIANTS
- Polish
- Warianty polipeptydu interferonu gamma
Classification
- CPC, 4
- C07K14/57
- A61P11/00
- A61P31/12
- A61P35/00
- IPC, 8
- A61K38 21
- A61K47 34
- A61K47 48
- C12N15 09
- A61P11 00
- C07K14 57
- C12N5 10
- C12P21 02