PL366376A1
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
Abstract
Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups ZR4R5 taken together comprise an NH-subsituted aryl.
Term
Term ended
Projected expiry passed 7 November 2021, 4.9 years ago.
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72 members in 39 offices
Priority claims8
| Document | Office | Kind | Date |
|---|---|---|---|
| 24987700 | United States of America | P | |
| 24987700 | United States of America | P | |
| 31056101 | United States of America | P | |
| 31056101 | United States of America | P | |
| 0060249877 | – | – | – |
| 0160310561 | – | – | – |
| US20000249877P | – | – | – |
| US20010310561P | – | – | – |
Members72
| Document | Office | Kind | |
|---|---|---|---|
| CA2429628A1 | Canada | A1 | |
| WO0240486A2 | World Intellectual Property Organization (WIPO) | A2 | |
| AU2002232760C1 | Australia | C1 | |
| AU3276002A | Australia | A | |
| UY27024A1 | Uruguay | A1 | |
| PE20020819A1 | Peru | A1 | |
| US2003069244A1 | United States of America | A1 | |
| IS6816A | Iceland | A | |
| NO20032229D0 | Norway | D0 | |
| KR20030045195A | Republic of Korea | A | |
| NO20032229L | Norway | L | |
| WO0240486A3 | World Intellectual Property Organization (WIPO) | A3 | |
| US2003186982A1 | United States of America | A1 | |
| CZ20031370A3 | Czechia | A3 | |
| EE200300227A | Estonia | A | |
| AR032637A1 | Argentina | A1 | |
| IL155570D0 | Israel | D0 | |
| EP1363910A2 | European Patent Office (EPO) | A2 | |
| US6670357B2 | United States of America | B2 | |
| BG107750A | Bulgaria | A | |
| MXPA03004290A | Mexico | A | |
| HU0303897A2 | Hungary | A2 | |
| HK1057555A1 | Hong Kong, China | A1 | |
| CA2505365A1 | Canada | A1 | |
| WO2004043912A2 | World Intellectual Property Organization (WIPO) | A2 | |
| AU2003287514A1 | Australia | A1 | |
| SK5402003A3 | Slovakia | A3 | |
| WO2004043912A3 | World Intellectual Property Organization (WIPO) | A3 | |
| JP2004522713A | Japan | A | |
| TW200413382A | Taiwan Province of China | A | |
| ZA200303786B | South Africa | B | |
| HRP20030485A2 | Croatia | A2 | |
| US2004229877A1 | United States of America | A1 | |
| PL366376A1This record | Poland | A1 | |
| US6867300B2 | United States of America | B2 | |
| US2005107462A1 | United States of America | A1 | |
| CN1622946A | China | A | |
| NZ525334A | New Zealand | A | |
| MXPA05004748A | Mexico | A | |
| BR0115446A | Brazil | A | |
| EP1562949A2 | European Patent Office (EPO) | A2 | |
| KR20050084961A | Republic of Korea | A | |
| BR0316056A | Brazil | A | |
| CO5560547A2 | Colombia | A2 | |
| UA74024C2 | Ukraine | C2 | |
| PL377112A1 | Poland | A1 | |
| CN1735615A | China | A | |
| EP1363910B1 | European Patent Office (EPO) | B1 | |
| AT318820T | Austria | T | |
| DE60117607D1 | Germany | D1 | |
| JP2006514622A | Japan | A | |
| YU37903A | Yugoslavia, later Serbia and Montenegro (until 2006) | A | |
| PT1363910E | Portugal | E | |
| DK1363910T3 | Denmark | T3 | |
| SI1363910T1 | Slovenia | T1 | |
| GEP20063915B | Georgia | B | |
| ES2259051T3 | Spain | T3 | |
| MY127066A | Malaysia | A | |
| AU2002232760B2 | Australia | B2 | |
| DE60117607T2 | Germany | T2 | |
| US7211666B2 | United States of America | B2 | |
| EP1562949A4 | European Patent Office (EPO) | A4 | |
| TWI290555B | Taiwan Province of China | B | |
| CN100360532C | China | C | |
| RU2316556C2 | Russian Federation | C2 | |
| KR100847605B1 | Republic of Korea | B1 | |
| US2009227567A1 | United States of America | A1 | |
| EP1562949B1 | European Patent Office (EPO) | B1 | |
| AT453645T | Austria | T | |
| DE60330800D1 | Germany | D1 | |
| ES2337571T3 | Spain | T3 | |
| JP4662775B2 | Japan | B2 |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)REFS | REFS |
Numbers
- Publication, DOCDB
- 366376
- Publication, EPODOC
- PL366376
- Application
- 1366376
- Application, DOCDB
- 36637601
- Application, EPODOC
- PL20010366376
Titles2
- English
- METHODS OF TREATING P38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS
- Polish
- Sposoby leczenia stanów związanych z kinazą p38 izwiązki pirolotriazynowe użyteczne jako inhibitory kinazy
Classification
- CPC, 17
- C07D487/04
- A61P1/04
- A61P11/00
- A61P11/06
- A61P17/02
- A61P17/06
- A61P19/02
- A61P19/06
- A61P19/10
- A61P25/28
- A61P29/00
- A61P31/14
- A61P37/06
- A61P39/02
- A61P43/00
- A61P9/10
- A61P3/10
- IPC, 26
- A61K31 53
- A61K31 5377
- A61K31 551
- A61P1 04
- A61P3 10
- A61P9 10
- A61P11 00
- A61P11 06
- A61P17 02
- A61P17 06
- A61P19 02
- A61P19 06
- A61P19 10
- A61P25 28
- A61P29 00
- A61P31 14
- A61P37 06
- A61P39 02
- A61P43 00
- C07D
- C07D209 00
- C07D253 00
- C07D471 00
- C07D487 00
- C07D487 04
- C07D519 00