Nova Patents
PL2800811T3

Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription

Abstract

The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Term

6.5 yearsto projected expiry

Projected expiry 15 March 2033, counted from filing; an application has no term until it is granted.

  1. Priority
  2. Filed
  3. Published
  4. Today
  5. Projected expiry

1 claim: 1 independent, 0 dependent

  1. 1
    Zastrzeżenia patentowe 1. Sposób modyfikowania docelowego DNA, przy czym sposób obejmuje kontaktowanie docelowego DNA z kompleksem zawierającym:(a) polipeptyd Cas9 i (b) jednocząsteczkowy RNA-ukierunkowujący DNA zawierający: (i) segment-ukierunkowujący DNA zawierający sekwencję nukleotydową, która jest komplementarna do sekwencji w docelowym DNA;i (ii) segment wiążący białko, który współdziała z tym polipeptydem Cas9, przy czym segment wiążący białko zawiera dwa komplementarne odcinki nukleotydów, które hybrydyzują dla utworzenia dwuniciowego dupleksu RNA (dsRNA), przy czym te dwa komplementarne odcinki nukleotydów są kowalencyjnie połączone za pomocą nukleotydów interweniujących, przy czym kontaktowanie jest in vitro lub w komórce ex vivo;i przy czym modyfikowanie polega na cięciu docelowego DNA. 2. Sposób według zastrzeżenia 1, przy czym dupleks dsRNA ma długość od 8 par zasad (pz) do 30 pz. 3. Sposób według zastrzeżenia 1 albo 2, przy czym procentowa komplementarność pomiędzy nukleotydami, które hybrydyzują dla wytworzenia dupleksu dsRNA segmentu wiążącego białko jest większa niż 70%. 4. Sposób według zastrzeżenia 1, 2 albo 3, przy czym docelowy DNA obecny jest w komórce bakteryjnej, w komórce archeobakteryjnej, pojedynczym komórkowym organizmie eukariotycznym, komórce roślinnej, komórkach bezkręgowców lub komórkach kręgowców. 5. Sposób według zastrzeżenia 1, 2 albo 3, przy czym docelowym DNA jest chromosomalny DNA. 6. Sposób według dowolnego z poprzednich zastrzeżeń, przy czym kontaktowanie obejmuje wprowadzanie do komórki (a) polipeptydu Cas9 lub polinukleotydu kodującego polipeptyd Cas9 i (b) RNA-ukierunkowującego DNA lub polinukleotydu DNA kodującego RNA-ukierunkowujący DNA. 7. Sposób według zastrzeżenia 6, przy czym sposób dodatkowo obejmuje wprowadzanie do komórki polinukleotydu donorowego. 8. Sposób według dowolnego z poprzednich zastrzeżeń, przy czym domena transdukcji białka jest kowalencyjnie związana z końcem aminowym polipeptydu Cas9, przy czym domena transdukcji białka ułatwia przechodzenie polipeptydu Cas9 z cytosolu do organelli komórki. -1959. Sposób według dowolnego z zastrzeżeń 1-7, przy czym domena transdukcji białka jest kowalencyjnie związana z końcem karboksylowym polipeptydu Cas9, przy czym domena transdukcji białka ułatwia przechodzenie polipeptydu Cas9 z cytosolu do organelli komórki. 10. Kompozycja zawierająca: (a) polipeptyd Cas9 lub polinukleotyd kodujący polipeptyd Cas9, i (b) jednocząsteczkowy RNA-ukierunkowujący DNA lub polinukleotyd DNA kodujący RNA-ukierunkowujący DNA, przy czym jednocząsteczkowy RNAukierunkowujący DNA zawiera: (i) segment-ukierunkowujący DNA zawierający sekwencję nukleotydową, która jest komplementarna do sekwencji w docelowym DNA;i (ii) segment wiążący białko, który współdziała z tym polipeptydem Cas9, przy czym segment wiążący białko zawiera dwa komplementarne odcinki nukleotydów, które hybrydyzują dla utworzenia dwuniciowego dupleksu RNA (dsRNA), przy czym te dwa komplementarne odcinki nukleotydów są kowalencyjnie połączone za pomocą nukleotydów interweniujących. 11. Kompozycja według zastrzeżenia 10, przy czym domena transdukcji białka jest kowalencyjnie związana z końcem aminowym polipeptydu Cas9, przy czym domena transdukcji białka ułatwia przechodzenie polipeptydu Cas9 z cytosolu do organelli komórki. 12. Kompozycja według zastrzeżenia 10, przy czym domena transdukcji białka jest kowalencyjnie związana z końcem karboksylowym polipeptydu Cas9, przy czym domena transdukcji białka ułatwia przechodzenie polipeptydu Cas9 z cytosolu do organelli komórki. 13. Kompozycja według dowolnego z zastrzeżeń 10-12, przy czym (a) polipeptyd Cas9 lub polinukleotyd kodujący polipeptyd Cas9, i (b) jednocząsteczkowy RNAukierunkowujący DNA lub polinukleotyd DNA kodujący RNA-ukierunkowujący DNA są w komórce in vitro lub ex vivo, przy czym komórka nie jest ludzką komórką zarodkową. 14. Jednocząsteczkowy RNA-ukierunkowujący DNA lub polinukleotyd DNA kodujący RNA-ukierunkowujący DNA, przy czym jednocząsteczkowy RNA-ukierunkowujący DNA zawiera: (a) segment-ukierunkowujący DNA zawierający sekwencję nukleotydową, która jest komplementarna do sekwencji w docelowym DNA;i (b) segment wiążący białko, który współdziała z tym polipeptydem Cas9, przy czym segment wiążący białko zawiera dwa komplementarne odcinki -196nukleotydów, które hybrydyzują dla utworzenia dwuniciowego dupleksu RNA (dsRNA), i przy czym te dwa komplementarne odcinki nukleotydów są kowalencyjnie połączone za pomocą nukleotydów interweniujących. 15. Jeden lub więcej kwasów nukleinowych zawierających: (a) pierwszą sekwencję nukleotydową kodującą jednocząsteczkowy RNAukierunkowujący DNA, zawierający: (i) segment-ukierunkowujący DNA zawierający sekwencję nukleotydową, która jest komplementarna do sekwencji w docelowym DNA;i (ii) segment wiążący białko, który współdziała z tym polipeptydem Cas9, przy czym segment wiążący białko zawiera dwa komplementarne odcinki nukleotydów, które hybrydyzują dla utworzenia dwuniciowego dupleksu RNA (dsRNA), i przy czym te dwa komplementarne odcinki nukleotydów są kowalencyjnie połączone za pomocą nukleotydów interweniujących;przy czym pierwsza sekwencja nukleotydowa kodująca RNA-ukierunkowujący DNA jest połączona funkcjonalnie z promotorem;i opcjonalnie, (b) drugą sekwencję nukleotydową kodującą polipeptyd Cas9, przy czym druga sekwencja nukleotydową kodująca polipeptyd Cas9 jest połączona funkcjonalnie z promotorem. 16. Jeden lub więcej kwasów nukleinowych według zastrzeżenia 15, przy czym kwasy nukleinowe stanowią jeden lub więcej rekombinowanych wektorów ekspresyjnych. 17. Jeden lub więcej kwasów nukleinowych według zastrzeżenia 15, przy czym jeden lub więcej rekombinowanych wektorów ekspresyjnych stanowią jeden lub więcej wektorów wirusowych. 18. Zestaw zawierający (a) polipeptyd Cas9 lub kwas nukleinowy zawierający sekwencję nukleotydową kodującą polipeptyd Cas9;i (b) jednocząsteczkowy RNA-ukierunkowujący DNA lub kwas nukleinowy zawierający sekwencję nukleotydową kodującą ten jednocząsteczkowy RNAukierunkowujący DNA, przy czym jednocząsteczkowy RNA-ukierunkowujący DNA zawiera: (i) segment ukierunkowujący- DNA zawierający sekwencję nukleotydową, która jest komplementarna do sekwencji w docelowym DNA;i (ii) segment wiążący białko, który współdziała z polipeptydem Cas9, przy czym segment wiążący białko zawiera dwa komplementarne -197odcinki nukleotydów, które hybrydyzują dla utworzenia dwuniciowego dupleksu RNA (dsRNA), i przy czym te dwa komplementarne odcinki nukleotydów są kowalencyjnie połączone za pomocą nukleotydów interweniujących;przy czym (a) i (b) są w tych samych lub oddzielnych pojemnikach. 19. Kompozycja według dowolnego z zastrzeżeń 10-13, jednocząsteczkowy RNAukierunkowujący DNA lub polinukleotyd DNA kodujący RNA-ukierunkowujący DNA według zastrzeżenia 14, jeden lub więcej kwasów nukleinowych według dowolnego z zastrzeżeń 15-17 lub zestaw według zastrzeżenia 18, przy czym dupleks dsRNA ma długość od 8 par zasad (pz) do 30 pz. 20. Kompozycja według dowolnego z zastrzeżeń 10-13 albo 19, jednocząsteczkowy RNA-ukierunkowujący DNA lub polinukleotyd DNA kodujący RNAukierunkowujący DNA według zastrzeżenia 14 lub 19, jeden lub więcej kwasów nukleinowych według dowolnego z zastrzeżeń 15-17 lub 19, lub zestaw według zastrzeżenia 18 lub 19, przy czym procentowa komplementarność pomiędzy nukleotydami, które hybrydyzują dla wytworzenia dupleksu dsRNA segmentu wiążącego białko jest większa niż 70%. 21. Kompozycja według dowolnego z zastrzeżeń 10-13, 19 albo 20, jednocząsteczkowy RNA-ukierunkowujący DNA lub polinukleotyd DNA kodujący RNAukierunkowujący DNA według dowolnego z zastrzeżeń 14, 19 lub 20, jeden lub więcej kwasów nukleinowych według dowolnego z zastrzeżeń 15-17, 19 lub 20, lub zestaw według dowolnego z zastrzeżeń 18, 19 lub 20, docelowy DNA obecny jest w komórce bakteryjnej, w komórce archeobakteryjnej, pojedynczym komórkowym organizmie eukariotycznym, komórce roślinnej, komórkach bezkręgowców lub komórkach kręgowców. 22. Kompozycja według dowolnego z zastrzeżeń 10-13 albo 19-21, jednocząsteczkowy RNA-ukierunkowujący DNA lub polinukleotyd kodujący RNA-ukierunkowujący DNA według dowolnego z zastrzeżeń 14 lub 19-21, jeden lub więcej kwasów nukleinowych według dowolnego z zastrzeżeń 15-17 lub 19-21, lub zestaw według dowolnego z zastrzeżeń 18-21, przy czym docelowy DNA jest chromosomalnym DNA. 23. Kompozycja według dowolnego z zastrzeżeń 10-13 albo 19-22, lub jednocząsteczkowy RNA-ukierunkowujący DNA lub polinukleotyd kodujący RNAukierunkowujący DNA według dowolnego z zastrzeżeń 14 lub 19-22, lub jeden lub więcej kwasów nukleinowych według dowolnego z zastrzeżeń 15-17 lub 19-22, do stosowania w sposobie leczenia terapeutycznego pacjenta. 198- -199- -200Cas9/Csn1 Streptococcus pyoaenes motywy *_ MDKKYSIGLDIGTNSVGWAVITDDYKVPSKKLKGLGNTDRHGIKKNLIGALL FDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLEE SFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLADSTDKVDLRLIYL ALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASRVDA KAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAED AKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEITK APLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGG ASQEEFYKFIKPILEKMDGTEELLAKLNREDLLRKQRTFDNGSIPYQIHLGEL HAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEE TITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYN ELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIEC FDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFED REMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTI LDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGS PAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERM KRIEEGIKELGSDILKEYPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRL *_ SDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYW RQLLNAKLITQRKFDNLTKAERGGLSELDKVGFIKRQLVETRQITKHVAQILD SRMNTKYDENDKLIREVRVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAY LNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYS NIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQV NIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVL VVAKVEKGKSKKLKSVKELLGITIMERSSFEKDPIDFLEAKGYKEVRKDLIIKL PKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSP EDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPI REQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLY ETRIDLSQLGGD FIG. 3A -201Cas9/Csn1 Streptococcus pyoaenes Domeny MDKKYSIGLDIGTNSVGWAVITDDYKVPSKKLKGLGNTDRHGIKKNLIGAL LFDSGETAEATRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLE ESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLADSTDKVDLRLI YLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASRV DAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLA EDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEI TKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYID GGASQEEFYKFIKPILEKMDGTEELLAKLNREDLLRKQRTFDNGSIPYQIHL GELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRK SEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTV YNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKI ECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLF EDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSG KTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLA 2 GSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSR ERMKRIEEGIKELGSDILKEYPVENTQLQNEKLYLYYLQNGRDMYVDQEL DINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKK MKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKVGFIKRQLVETRQIT KHVAQILDSRMNTKYDENDKLIREVRVITLKSKLVSDFRKDFQFYKVREIN NYHHAHDAYLNAWGTALIKKYPKLESE F VYG D YKVYDVRKMIAKS EQ EIG KATAKYFFYSNIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATV RKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGF DSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKDPIDFLEAKGY KEVRKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLA SHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVL SAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLD ATLIHQSITGLYETRIDLSQLGGD FIG. 3B -2020 LL fid -203- Motyw 3 * -204- innocua (1)----OTUGUdmUUClmAIMCAUAGCAAGUUAAAAUAAGGCl-------lUUUl·-----KJCCGUU < 01 -205- FIG. 7 -206- FIG. 8 -207- Listeria innocua Parowanie zasad in vivo (crRNA/tracrRNA) 5'- variable 20nt GUUUUAG—AGCUAUGUUAUUUUG-3' *11111* I I I I I I I I I I I I UGCCGCGAUGAAUUAAUUUUCAACUAUUGCCUGUUUCGGAAUAAAAUUGAACGAUACAAUAAA-5' u mm UGGGCGCUUUUUU-3' Przykład jednoczgsteczkowego RNA-ukierunkowującego DNA 5'---20nt----GUUUUAG—AGCUA A •...... I I I I ) 3'-GCCUGUUUCGGAAUAAAAUUGAACGAUk J FIG. 9 -208- FIG. 10 -209primer wiążący niekomplementarną nić -210- -211protospacer 2 oligonukleotyd DNA ® protospacer 2 H H a /_ οϋ jnukleotyd DNA λ. % '’λ. CM < O. Z <P έ < u ± 2 L ** * * */ */ \ % *> I I I 2. | (0 £ co CM w m co CM FIG. 12 -212- -213- FIG. 12 (kontynuacja 2) -214- -215- FIG. 13 -216protospacer 4 oligonukleotyd DNA -217- FIG. 13 (kontynuacja 2) -218- -219- -220cd m 'sr -221 -222- < (nVLu) eiodjosqv objętość elucji (ml) CD o LL -223- O. CD CO ID Xł ' FIG. 17 -224Β protospacer 1 oligonukleotyd DNA crRNA-sp4 niekomplementarny PAM 5'-TGCGCTGGTTGATTTCTTCTTGCGCTTTTT.GGGTATTGGGGAATTCATTA-3' 1111111111 o 1111111111111111 3'-ACGCGACCAACTAAAGAAGAACGCGAAAAAĆGC;ATAACCCCTTAAGTAAT-5' komplementarny I 11111111 111 111111 11_ 5' -GWUĆUWHG^GĆUUaU^UUUUAGAGCUAUGCUGUUUUGl· 3' CrRNA-Sp1 •lilii- llllllllllllll AGCCACGGUGAAAAAGUUCAACUAUUGCCUGAUCGGAAUAAAAUU CGAUACGACAAAACUUACCAAGGUUG-5' -225- -226- -227protospacer 4 oligonukleotyd DNA FIG. 18(cd.) -228protospacer 4 o I i go nukleotyd D N A FIG. 19 -229φΩ SLi ι/i ο 2 φ ο Μ 1- ο 0.Ό LD I ο ο ο ο ο οο φΩ οο ld ι ι Η — < ο — ο ο — ο ο — υ ο ο — ο ο — ο Η — < Η — < Η — Η — < Η — < _ O — Ο. S ·Ο'·;·?Α·.;Ο·. u>i ο υ ο υ 3Ξ ο < Ξ < _ ο < Ξ = - < = 3 - < — ο - < — ο — ο — < — ο - < — ο — ο 0.5 «/) ο ο Φ ο ο 1- Ο 0-Ό Λ LiO οο LO I Ο ο < < ο ο < - < =3 - < • ο Ο ο ο ο < ο ο ο ο ο < η ο < Η — : ο ο ο u ο Η Ο Ο < Ο — ο — = < ο — ο — ο — ο — < ο — ο — Η — < < Fi — Η — - < = 3 - < — ο — ο — < — ο - < — ο — ο - < - < • ο < < ο ο ο ο < ο ο ο ο ο -230WWRr IJęNwwt nie poddany wstępnemu annealingowi/ nie inkubowany wstępnie 0.5 1 2 5 7.510 20 40 60 nie poddany wstępnemu annealingowi/ wstępnie inkubowany 0.5 1 2 5 7.510 20 40 6O.min "produkt cięcia superskręcony 100Φ O) > (0 o 10 20 30 40 50 60 t (min) 20mirr 1 warunek obs 0.47 ± 0.04 poddany wstępnemu annealingowi/ wstępnie inkubowany nie poddany wstępnemu annealingowi/ 0.89 + 0.12 nie inkubowany wstępnie poddany wstępnemu annealingowi/ 0.31 ±0.01 nie inkubowany wstępnie nie poddany wstępnemu annealingowi/ 1.04 ± 0.10 wstępnie inkubowany a poddany wstępnemu annealingowi/ ^wstępnie inkubowany Qnie poddany wstępnemu annealingowi/ ''“nie inkubowany wstępnie g poddany wstępnemu annealingowi/ nie inkubowany wstępnie []nie poddany wstępnemu annealingowi/ wstępnie inkubowany poddany wstępnemu annealingowi/ wstępnie inkubowany 0.5 1 2 5 7.510 20 40 60 poddany wstępnemu annealingowi/ nie inkubowany wstępnie 0.5 1 2 5 7.510 20 40 60 min produkt cięcia superskręcony FIG. 20 -231produkt cięcia (nM) -232A protospacer 1 docelowy plazmid DNA okrągły linearny -6300 bp -4950 bp -1350 bp protospacer 4 oliginukleotyd DNA komplementarna niekomplementarna -233- FIG. 22 -234FIG. 23 protospacer 1 docelowy oligonukleotyd DNA crRNA-sp1 tracrRNA Cas9 nt nt -235FIG. 23(cd.) protospacer 4 docelowy oligonukleotyd DNA crRNA-sp4 tracrRNA Cas9 nt nt -236- -237protospacer 1 oligonukleotyd DNA komplementarny niekomplementarny -238- FIG. 24 (cd. 2) -239- FIG. 24(cd. 3) -240- -241- -242- LO CM LL Próbka docelowego DNA -243- -244tracrRNA tracrRNA tracrRNA crRNA-sp4 tracrRNA crRNA-sp4 crRNA-sp4 + Cas9 crRNA-sp4 + Cas9 -TAATCCAC-5' 3'-TTTTTAAT -245CFU/pg DNA Cas9 — + + + docelowy protospacer 2 PAM WT 5'-ATAACTCAATTTGTAAAAAA-GGGTA-3' PAM G^C 5'-ATAACTCAATTTGTAAAAAA-GCGTA-3' PAM GG->CC5'-ATAACTCAATTTGTAAAAAA-GCCTA-3' FIG. 26 -246WT PAM1 PAM2 PAM3 PAM4 DPAM plazmid docelowy 5' 5' 5' 5' 5' 5' docelowy protospacer 4 PAM -AAAAATTAGGTGCGCTTGGC-TGGCG-3' -AAAAATTAGGTGCGCTTGGC-TCGCG-3' -AAAAATTAGGTGCGCTTGGC-TGCCG-3' -AAAAATTAGGTGCGCTTGGC-TGGCC-3' -AAAAATTAGGTGCGCTTGGC-TCCCC-3' -AAAAATTAGGTGCGCTTGGC-T-3' FIG. 26 (cd.) <—800 bp <—2640 bp <—1880 bp kbp 10.0 -247 -248- -249AmpR 9522 ... 10181 FIG. 28 -250Sekwencja docelowa -251- -252- FIG. 29 -253sgRNA FIG. 29 (Cd. Ί) ZFN R -TCAGTCCTCATCTCCCTCAAGCAGGCCCCGCTGGTGCACTGAAGAGCCACCCTGTGGAAACACTACATCTGCAA-3 AGTCAGGAGTAGAGGGAGTTCGTCCGGGGCGACCACGIGACTGCTCGGIKjGGACACCTTTGTGATGTAGACGTT-S' CLTA1 sgRNA ZFN-L Cas9 doce owe DNA PAWI GCCUGAUCGGAAUAAAAUU CG AU GAA sgRNA 2na 1 st seg U6 Pol seg -254- U6-CLTA1 sgRNA -- + + FIG. 29 (cd. 2) -255A Cas9-GFP plazmid _ + + _ + ZFN U6-CLTA1 sgRNA plazmid --- + + transkrybowany in vitro CLTA1 sgRNAdodany do lizatuCTRL Cas9-GFP U6-CLTA1 sgRNA plazmid - + - + transkrybowany in vitro CLTA1 sgRNA dodany do lizatu - - + + FIG. 30 -256CTLA1 sgRNA U6 (Pol III) > 1 st seg. ΊΧ 1 2 nd seg. TTTTTTTT 5'-GCAGAUGUAGUGUUUCCACAGUUUUAGAGCUA G •lilii· llll 3'-GCCUGAUCGGAAUAAAAUU CGAU* GAA v1.0 5'-GCAGAUGUAGUGUUUCCACAGUUUUAGAGCUAUGCU G •mu· iiiiiiii 3’-CUAUUGCCUGAUCGGAAUAAAAUU CGAUACGA^ GAA v2.1 -GCAGAUGUAGUGUUUCCACAGUUUUAGAGCUAUGCUGUUUUG u •mu· mmmmii 3'-CUAUUGCCUGAUCGGAAUAAAAUU CGAUACGACAAAAC A GAA v2.2 FIG. 31 -257- FIG. 31 (c.d.) -258FIG 32A ΙΙ-Α Francisella novicida U112 Wolinella succinoaenes DSM 1740+ protobakteria gamma HTTC 5015 - Sutterella wadsworthensis 3 1 45B - Parasutterella excrementihominis\\T 11859 Legionella pneumophila str. Paris —Listeria-innocua Clip11262 ) r Streptococcus thermophilus LMD-9 -rf-r Streptococcus mutans UA159 81*Streptococcus pyogenes M1 GAS Fusobacterium nucleatum ATCC 49256 Filifactor alocis ATCC 35896 Peptoniphilus duerdenii ATCC BAA-1640 Treponema denticola ATCC 35405 —Coprococcus catus GD-7 Solobacterium moorei F0204 - Veillonella afyp/ca ACS-134-V-Col7a - Acidaminococcus intestini RyC-MR95 -Finegoldia magna ATCC 29328 Olsenella uli DSM 7084 Lactobacillus rhamnosus GG Lactobacillus gasseri JV-V03 Catenibacteńum mitsuoka\ DSM 15897 - Oenococcus kitaharae DSM 17330 - Bifidobacterium bifidum S17 Staphylococcus pseudintermedius ED99 Eubacterium rectale ATCC 33656 —Enterococcus faecalis ΤΧ0012 Streptococcus thermophilus LMD-9** Staphylococcus lugdunensis M23590 - Eubacterium dolichum DSM 3991 Mycoplasma mobile 163K Mycoplasma ovipneumoniae SC01 r— Mycoplasma gallisepticum str. F 96*—Mycoplasma canis PG 14 — Mycoplasma synoviae 53 -25951 6 Bacillus cereus Rocki-15 98M llyobacterpolytropus DSM 2926 —Aminomonas paucivorans DSM 12260 Lg—Clostridium perfringens D JGS1721 — Clostridium cellulolyticum H10 53— Acidovorax ebreus TPSY $5— Neisseria meningitidis Z2491 '^Pasteurella multocida Pm70 - niehodowane bakterie grupy Termite 1 RS-D17 Wolinella succinogenes DSM 1740ł Campylobacter jejuni NCTC 11168 - Helicobacter mustelae 12198 ll-C — Roseburia intestinalis L1-82 Lactobacillus coryniformis KCTC 3535 -Ruminococcus albus 8 (vi) —Rhodopseudomonas palustris BisB18 r^-Cand. Puniceispirillum marinum I MCC 1322 100 Verminephrobacter eiseniae E F 01 -2 Ralstonia syzygii R24 Azospirillum sp. B510 —Nitrobacter hamburgensis X14 —Bradyrhizobium sp. BTAil Dinoroseobacter shibae DFL 12 -Rhodospirillum rubrum ATCC 11170 Elusimicrobium minutum Pei191 Sphaerochaeta globus str. Buddy ~Prevotella ruminicola 23 Flavobacterium columnare ATCC 49512 L 56 *—99 -Prevotella micans F0438 Parvibaculum lavamentivorans DS-1 Bacteroides fragilis NCTC 9343 Capnocytophaga ochracea DSM 7271 Fibrobacter succinogenes S85 - Nitratifractor salsuginis DSM 16511 —Akkermansia muciniphila ATCC BAA-835 -Acidothermus cellulolyticus 11B -Corynebacterium diphtheriae NCTC 13129 99^|_|^e/7/£yoibacier/i/ / n longum DJO10A Bifidobacterium dentium Bd1 FIG. 32A (c.d.) (vii) -260- (iv) 36 -1150 (ν) 36 -1300 (ν) 36 -1050 (νϋ) 44-48 -1400 (viii) 36 -1100 FIG. 32B -261- -262- Bifidobacterium bifidum S17 -fcięąśi FIG. 33 (c.d. 1) -263c Typ ll-B (c.d.) I Staphylococcus pseudintermedius ED99 Eubacterium rectale ATCC 33656 Enterococcus faecalis ΤΧ0012 Streptococcus thermophilus LMD-9 Staphylococcus lugdunensis M23590 Eubacterium dolichum DSM 3991 Mycoplasma mobile 163K Mycoplasma ovipneumoniae SC01 Mycoplasma gallisepticum str. F Mycoplasma canis PG 14 Mycoplasma synoviae 53 FIG. 33 (c.d. 2) -264Typ ll-C Bacillus cereus Rocki -15 llyobacter polytropus DSM 2926 Aminomonas paucivorans DSM 12260 Clostridium perfringens D JGS1721 Clostridium cellulolyticum H10 Acidovorax ebreus TPSY Neisseria meningitidis Z2491 Pasteurella multocida Pm70 uncult. Termite group 1 bact. Rs-D17 Wolinella succinogenes DSM 1740 Campylobacter jejuni NCTC 11168 Helicobacter mustelae 12198 Roseburia intestinalis L1-82 Lactobacillus coryniformis KCTC 3535 Ruminococcus albus 8 Rhodopseudomonas palustris BisB 18 Cand. Puniceispirillum marinum IMCC 1322 Verminephrobacter eiseniae EF01 -2 Ralstonia syzygii R24 Azospirillum sp. B510 Nitrobacter hamburgensis Χ14 Bradyrhizobium sp. BTAil FIG. 33 (c.d. 3) -265Typ ll-C (c.d.) Dinoroseobacter shibae DFL12 Rhodospirillum rubrum ATCC 11170 Elusimicrobium minutum Pei191 Sphaerochaeta globus str. Buddy Prevotella ruminicola 23 Flavobacterium columnare ATCC 49512 Prevotella micans F0438 Parvibaculum lavamentivorans DS-1 Bacteroides fragilis NCTC 9343 Capnocytophaga ochracea DSM 7271 Fibrobacter succinogenes S85 Nitratifractor salsuginis DSM 16511 Akkermansia muciniphila ATCC BAA-835 Acidothermus cellulolyticus 11B Corynebacterium diphtheriae NCTC 13129 Bifidobacterium longum DJO10A Bifidobacterium dentium Bd1 FIG. 33 (c.d. 4) -266- -267FIG. 34 (c.d.) C.yę/i/n/NCTC 11168 W/AAA -□ODOEk—O GUUUUAGUCCCUUUUUAAAUUUCUUUAUGGUAAAAU 3' 5' 5' GUUGUAGCUCCCUUUCUCAUUUCGCAGUGCUACAAU 3' olllllll | III llll II IIIIIIII lilii 3' UAACAUCGUUGCCAAGAGUAAAGCGUCACGCUGUUAUA 5' N meningitidis Z2491 +12 -268- FIG. 35 -269- FIG. 35 (c.d.) -270MOjAzDpo q2XueModeiuz^g^|,gg lunidi □ MOłAzDpo q?XueModeiuz S0Z8P epioiAOu j a a o (O T - N oo a O CO IO in IO o 3DAa»0d 3DAaX0d io FIG. 36 tracrRNAs -271crRNAs m u φ m u φ c o n O O CM CM i O 8 3DAd>IOd O. J2 O O co" O O CO s." T - CO FIG. 36 (c.d. 1) MO)Xz3po ipAueMOdeiuz P8LPL66 M 9Mz3po ipZueModeiuz S028P Oj lunfaf -q epiDiAOu -j -272tracrRNAs -273crRNAs FIG. 36 (c.d. 3) -274- -2753 § u U O. O O w Ol <*» 3DAa»0d Ω. O O K Ol <*) FIG. 36 (c.d.5) MOlAzDpO ιρλ U EMO de LUZ g£22^S|, sueinui $ -276- FIG. 37 -277- -278- -279- -280- -281- -282- -283- -284- FIG. 37 ( Cd. 8) -285- FIG. 37 ( cd. 9) -286- -287- -288- FIG. 37( Cd. 12) -289- FIG. 37 ( cd. 13) -290- FIG. 37 ( Cd. 14) -291- FIG. 38 -292- FIG. 38( cd. ) -293 -294cas9 sgRNA chimera CD CD ŁO 'M" CO CM o CM CD CO !=> O U o o o CD O co < w CD O LO O O co o CM O v- n ._ _ o COD 0 < Of<DDDO P<0U << 6SB9P ąiueżfeiM CO < H O < H O O O «< O O O H >< LO co O o LL -295- FIG. 40( cd. 1) -296- -297- -298- (Log 10) (-) sgRNA -299- FIG. 42( cd. -300Odległość od Region A początku parowania kodonu zasad Względna odległość od początku kodonu Aktywność represyjna (względna) Obcięcia Rozciągnięcia Długość regionu parowania zasad sgRNA FIG. 43 -301- -302- FIG. 44 -303- (eio||ilu einsoupof) XzppXzoiifP|p5^ FIG. 44 (cd. i) -304- FIG-44 (cd.2) -305MSCV LTR pue ~ioo bp reporter chromosamatny kontrola ujemna (brak EG FP) FIG. 45 -306EGFP fluorescencja (a*u.) mCherry fluoresccncja {a.u.) -307tracrRNA Γ* ca$9 ca$1 ce$2 csn2 Γ* H--1-r--r^__._fs__r-^ J CR.SPR Χ^ϊυ br powtórzenie powtórzenie powtórzenie powtórzenie transkrypcja spacer spacer spacer o RNaza przetwarzanie post-transkrypcyjne J kompleks crRNA skanowanie DNA formowanie dupleksu RN A-DNA przerwanie nici podwójnej FIG. 46 ujhl) dsDNA -308- -309- -310&dCas9 dCas9 sgRNA-ukierunkowujące Lacl aktywacja mRFP acZ lacY'i represja ilosc odczytów (Log 10) (-sgRNA FIG. 49 1 2 3 4 5 ilość odczytów (LoglOj, (-) IPTG (} sgRNA Oł< OZ JflC - ™ 3 w Ό Λ ΰΰ ? ·“ c L — ]S + brak sgRNA {+H IPTG aktywacja racz acY t jacA mRFP represja -311FIG. 49 (cd.] sgRNA-ukierunkowujące LacZ 3 4 ilość odczytów (Logi0), (-) )PTG (-} sgRNA Ś N Z o raj o d· d< s s '§, 0» n tn u _ o X Sg ” Ł represja aktywacja tfCas9 mRFP -312- FIG. 50 -313- -314ΓΤ3 m o LL _l_I_I_ ur> o ιλ o 9uiXs^jd9j 3iuepej>}|S O J_I_1 < aufAseicUj ajuepe^s -315MSCV 5' LTR W FIG. 52 1500 bp reporterzy plazmidu MSCV 3'LTR SV40-EGFP reporter NISCV-EGFP reporter SY40-EGFP reporter Λ 12000 8000 4000 MSCV-EGFP reporter Φ c £ S j=C *8 £ 5 fluorescencja SV40 p EGFP Π H sgRNA (+) sgRNA -100 bp sgRNA IRES q EGFP -316OD600 " fluorecencja (a u.) " (a.u.) I t I Ł L {-) (-) W (*> {-I W (! NT1 - 1X - 10Χ - 10QX RuvC1 d€as9 sgRNA IX 10Χ 1ΜΧ (·) W (+) (+) HNH dCas9 (·) (♦) Μ NT1 sgRNA czas inkubacji FIG. 53 -317- FIG. 54 -318- FIG. 54 (cd. υ -319- FIG. 54 (cd. 2) -320 pU6 Γ* +1 gRNA koniec MSCV LTR dcas9 vP64 RFP nls x3 GAL4-VP64 (-) Cas9-VP64 (-) przewodnik RNA (-) 1UCJDO 1030 100 FIG. 55 -30-aktywacja składania “20-aktywaga składania mCMV komórki gRNA Γ* HEK 293 CSCGFP GaL4 UAS reporter chromosomatny -321komórki HEK293 z reporterem chromosomu GAL4 FIG. 55 CcdJ [+) GAL4*VP64 kontrola 10080C {-) kontrola [+) dCas9-VP64 {+) gRNA (+) GAL4’VP64 kontrola {+) dCase9-VP64&gRNA f-ι kontrola -322- przewodnik RNA -323- FIG. 57 -324- -325- Legenda: Methods and compositions for rna-directed target DNA modification and for RNAdirected modulation of transcription Uncultured Termite Artifitial sequence Synthetic amino acid sequence Synthetic nucleic acid sequence Gamma proteobacterium n at each of these position can be present or absent such that this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u Exemplary Uncultured bacterium Uncultured delta Sposoby i kompozycje do kierowanej RNA modyfikacji docelowego DNA i do modulacji transkrypcji kierowanej RNA Nie podlegająca hodowli [grupa] Termitowa Sekwencja sztuczna Syntetyczna sekwencja aminokwasowa Syntetyczna sekwencja nukleinowa Gammaproteobakteria n może być obecne lub nie w każdej pozycji tak, że ten region może zawierać gdziekolwiek od 12 do 80 nukleotydów. n to a, c, g, lub u Przykładowe Nie podlegająca hodowli bakteria Nie podlegająca hodowli delta Page 1 of 3790 SEQUENCE LISTING Jinek, Martin Doudna, Jennifer A. Charpentier, Emmanuelle Chyliński, Krzysztof Doudna Cate, James H. Lim, Wendell Qi, Lei METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION BERK-187WO US 61/652,086 2012-05-25 US 61/716,256 2012-10-19 US 61/757,640 2013-01-28 US 61/765,576 2013-02-15 1346 Patentln version 3.5 1 1056 PRT Pasteurella multocida 1 Met Gin Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 10 15 Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 20 25 30 Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 35 40 45 Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 50 55 60 Thr Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Leu Ala Lys 65 70 75 80 Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Ile Asp Leu Glu Lys 85 90 95 Gly Leu Pro Asn Gin Ala Trp Glu Leu Arg Val Ala Gly Leu Glu Arg 100 Arg Leu Ser Ala Ile Glu Trp Gly 115 120 His Arg Gly Tyr Leu Ser Lys Arg 130 135 Lys Glu Leu Gly Ala Leu Leu Ser 145 150 Leu Gin Ser Asp Asp Tyr Arg Thr 165 Phe Ala Lys Glu Glu Gly His Ile 180 His Thr Phe Asn Arg Leu Asp Leu 195 200 Ala Gin Gin His Gin Phe Gly Asn 210 215 Gin Tyr Met Thr Glu Leu Leu Met 225 230 Glu Ala Ile Leu Lys Met Leu Gly 245 Phe Lys Ala Ala Lys His Thr Tyr 260 Thr Lys Leu Asn Asn Leu Arg Ile 275 280 Leu Asn Glu Glu Glu Arg Gin Leu 290 295 Ser Lys Leu Thr Tyr Ala Gin Val 305 310 Gin Ala Ile Phe Lys His Leu Arg 325 Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 340 345 350 Glu Asn Gin Gly Leu Lys Asp Thr 355 360 Asp Leu Leu Asp Glu Ile Gly Thr 370 375 Glu Asp Ile Gin Gin Tyr Leu Thr 385 390 Asn Ala Leu Leu Val Ser Leu Asn 405 Leu Lys Ser Leu Arg Lys Ile Leu 420 Tyr Asp Gin Ala Cys Arg Glu Ile 435 440 Asn Gin Lys Thr Ser Gin Leu Leu 450 455 Arg Asn Pro Val Val Leu Arg Thr 465 470 Asn Ala Ile Ile Arg Gin Tyr Gly 485 Thr Gly Arg Glu Leu Gly Lys Ser 500 Lys Gin Gin Glu Asp Asn Arg Thr 515 520 Phe Lys Glu Leu Phe Ser Asp Phe 530 535 Ile Leu Lys Phe Arg Leu Tyr Glu 545 550 Ser Gly Lys Glu Ile Asn Ile His 565 Glu Ile Asp His Ala Leu Pro Phe 580 590 Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gin Asn Lys Gly Asn 595 600 605 Page 4 of 3790 Gin Thr Pro Tyr Glu Trp Leu Gin Gly Lys Ile Asn Ser Glu Arg Trp 610 615 620 Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gin Cys Ser Ala Ala Lys 625 630 635 640 Lys Gin Arg Leu Leu Thr Gin Val Ile Asp Asp Asn Lys Phe Ile Asp 645 650 655 Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 660 665 670 Ile Gin Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 675 680 685 Thr Pro Asn Gly Gin Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 690 695 700 Ile Lys Ala Arg Glu Asn Asn Asn Arg His His Ala Leu Asp Ala Ile 705 710 715 720 Val Val Ala Cys Ala Thr Pro Ser Met Gin Gin Lys Ile Thr Arg Phe 725 730 735 Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 740 745 750 Met Val Asp Gin Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 755 760 765 Pro Trp Ala Tyr Phe Arg Gin Glu Val Asn Ile Arg Val Phe Asp Asn 770 775 780 His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gin Ala 785 790 795 800 Asn His Gin Phe Val Gin Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 805 810 815 Lys Met Ser Gly Gin Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 820 825 830 Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gin Leu Lys 835 840 845 Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 850 855 860 Page 5 of 3790 Gly Tyr Tyr Ile Gly Leu Asp Arg Ala Thr Gly Asn Ile Ser Leu Lys 995 1000 1005 Pro Val Arg 1055 2 1368 PRT Streptococcus pyogenes 2 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 6 of 3790 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp Page 7 of 3790 260 265 270 Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 310 315 320 Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 390 395 400 Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 470 475 480 Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Page 8 of 3790 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 9 of 3790 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Page 10 of 3790 Pro Glu Asp Asn Glu Gin Lys Gin Leu Phe Val Glu Gin His Lys Page 11 of 3790 1250 1255 1260 Phe Phe Cys Arg Leu Ser Asp Ser Phe Tyr Val Asp Asn Glu Lys Arg Page 14 of 3790 Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu Asn Ile Val 610 615 620 Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gin Leu 625 630 635 640 Gin Gin Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 645 650 655 Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Met 660 665 670 Gly Ile Arg Asp Lys Gin Ser His Leu Thr Ile Leu Asp Tyr Leu Met 675 680 685 Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gin Leu Ile Asn Asp Ser 690 695 700 Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin Val Thr Thr Ala 705 710 715 720 Asp Lys Asp Ile Gin Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 725 730 735 Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val 740 745 750 Ser Val Met Gly Tyr Pro Pro Gin Thr Ile Val Val Glu Met Ala Arg 755 760 765 Glu Asn Gin Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg Pro Arg Tyr 770 775 780 Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys 785 790 795 800 Glu His Pro Thr Asp Asn Gin Glu Leu Arg Asn Asn Arg Leu Tyr Leu 805 810 815 Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Gin Asp Leu Asp 820 825 830 Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gin Ser 835 840 845 Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 850 855 860 Page 15 of 3790 Lys Leu Ile Pro Arg Lys Thr Asn Trp Asp Pro Met Lys Tyr Gly Page 16 of 3790 1100 1105 1110 Gly Leu Tyr Glu Ser Arg Lys Arg Leu Asp Asp 1325 1330 Page 17 of 3790 4 1368 PRT Streptococcus pyogenes 4 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 20 25 30 Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys 180 Leu Phe 185 Ile Gin Leu Val Gin Thr Tyr 190 Asn Gin Leu Phe 195 Glu Glu Asn Pro 200 Ile Asn Ala Ser Arg Val 205 Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Page 19 of 3790 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn 690 Arg Asn Phe Met Gin Leu 695 Ile His Asp Asp 700 Ser Leu Thr Phe Lys Glu Asp 705 Ile Gin Lys Ala 710 Gin Val Ser Gly Gin 715 Gly Asp Ser Leu 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Page 20 of 3790 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Val Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Gin Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gin Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 Page 21 of 3790 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Page 22 of 3790 5 1370 PRT Streptococcus agalactiae 5 Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Page 24 of 3790 Ser Met Ile Gin Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gin Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gin Glu Ile Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 530 535 540 Lys Gin Glu 545 Ile Phe Asp Gly Val 550 Phe Lys Glu His Arg Lys Val 555 Ser 560 Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 565 570 575 Page 25 of 3790 Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 595 600 605 Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gin Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 625 630 635 640 Tyr Lys Asp Leu Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asp Lys Glu Ser Gin Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 675 680 685 Gly Arg Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu 690 695 700 Ser Phe Lys Ser Ile Ile Ser Lys Ala Gin Ala Gly Ser His Ser Asp 705 710 715 720 Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Tyr Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Asn Gin Gly Arg Arg Asn Ser Arg Gin Arg Tyr Lys Leu 770 775 780 Leu Asp Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 785 790 795 800 Leu Lys Glu Tyr Pro Thr Asp Asn Gin Ala Leu Gin Asn Glu Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 820 Page 26 of 3790 825 830 Thr Val Val Val Lys Asp Asp Ile Glu Val Asn Asn Asp Thr Gly 1055 1060 1065 Page 27 of 3790 Page 28 of 3790 Glu Asp 1370 6 1345 PRT Streptococcus mutans 6 Page 29 of 3790 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe 370 Tyr Lys Tyr Leu Lys 375 Gly Leu Leu Asn Lys 380 Ile Glu Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Page 30 of 3790 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His Page 32 of 3790 Page 33 of 3790 1340 1345 7 1377 PRT Streptococcus agalactiae 7 Page 34 of 3790 Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 100 105 110 Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gin Glu Glu Lys Tyr Tyr 115 120 125 His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 130 135 140 Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Gin Lys Gin Tyr Gin Ala Phe Leu Glu Ile 180 185 190 Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gin Asn Val Asp 195 200 205 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Page 35 of 3790 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gin 370 375 380 Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys 485 Glu Lys Ser Ala Glu Ala Phe 490 Ile His Arg Met 495 Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Page 37 of 3790 Page 38 of 3790 Page 39 of 3790 8 1368 PRT Streptococcus pyogenes 8 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 20 25 30 Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Page 40 of 3790 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn 305 Ser Glu 310 Ile Thr Lys Ala Pro Leu 315 Ser Ala Ser 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys Page 42 of 3790 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Page 43 of 3790 Page 44 of 3790 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Page 45 of 3790 1310 1315 1320 1355 1360 1365 9 131 PRT Helicobacter hepaticus 9 Met Arg Ile Leu Gly Phe Asp Ile Gly Ile Thr Ser Ile Gly Trp Ala 15 10 15 Tyr Val Glu Ser Asn Glu Leu Lys Asp Cys Gly Val Arg Ile Phe Thr 20 25 30 Lys Ala Glu Asn Pro Lys Asn Gly Asp Ser Leu Ala Ala Pro Arg Arg 35 40 45 Glu Ala Arg Gly Ala Arg Arg Arg Leu Ala Arg Arg Lys Ala Arg Leu 50 55 60 Asn Ala Ile Lys Arg Leu Leu Cys Lys Glu Phe Glu Leu Asn Leu Asn 65 70 75 80 Asp Tyr Leu Ala Asn Asp Gly Glu Leu Pro Lys Ala Tyr Gin Thr Ser 85 90 95 Lys Asp Thr Lys Ser Pro Tyr Glu Leu Tyr Thr Ala Phe His Trp Ile 100 105 110 Ile Phe Ala Phe Cys Ser Ile Ala Ser Ser Leu Ser Asn Arg Gin Met 115 120 125 Leu Pro Ile 130 10 1059 PRT Wolinella succinogenes Page 46 of 3790 10 Met Ile Glu Arg Ile Leu Gly Val Asp Leu Gly Ile Ser Ser Leu Gly 15 10 15 Trp Ala Ile Val Glu Tyr Asp Lys Asp Asp Glu Ala Ala Asn Arg Ile 20 25 30 Ile Asp Cys Gly Val Arg Leu Phe Thr Ala Ala Glu Thr Pro Lys Lys 35 40 45 Lys Glu Ser Pro Asn Lys Ala Arg Arg Glu Ala Arg Gly Ile Arg Arg 50 55 60 Val Leu Asn Arg Arg Arg Val Arg Met Asn Met Ile Lys Lys Leu Phe 65 70 75 80 Leu Arg Ala Gly Leu Ile Gin Asp Val Asp Leu Asp Gly Glu Gly Gly 85 90 95 Met Phe Tyr Ser Lys Ala Asn Arg Ala Asp Val Trp Glu Leu Arg His 100 105 110 Asp Gly Leu Tyr Arg Leu Leu Lys Gly Asp Glu Leu Ala Arg Val Leu 115 120 125 Ile His Ile Ala Lys His Arg Gly Tyr Lys Phe Ile Gly Asp Asp Glu 130 135 140 Ala Asp Glu Glu Ser Gly Lys Val Lys Lys Ala Gly Val Val Leu Arg 145 150 155 160 Gin Asn Phe Glu Ala Ala Gly Cys Arg Thr Val Gly Glu Trp Leu Trp 165 170 175 Arg Glu Arg Gly Ala Asn Gly Lys Lys Arg Asn Lys His Gly Asp Tyr 180 185 190 Glu Ile Ser Ile His Arg Asp Leu Leu Val Glu Glu Val Glu Ala Ile 195 200 205 Phe Val Ala Gin Gin Glu Met Arg Ser Thr Ile Ala Thr Asp Ala Leu 210 215 220 Lys Ala Ala Tyr Arg Glu Ile Ala Phe Phe Val Arg Pro Met Gin Arg 225 230 235 240 Ile Glu Lys Met Val Gly His Cys Thr Tyr Phe Pro Glu Glu Arg Arg Page 48 of 3790 Val Ala Asn Ala Leu Val Arg Lys Tyr Gly Ala Phe Asp Arg Val His 500 505 510 Phe Glu Leu Ala Arg Glu Ile Asn Thr Lys Gly Glu Ile Glu Asp Ile 515 520 525 Lys Glu Ser Gin Arg Lys Asn Glu Lys Glu Arg Lys Glu Ala Ala Asp 530 535 540 Trp Ile Ala Glu Thr Ser Phe Gin Val Pro Leu Thr Arg Lys Asn Ile 545 550 555 560 Leu Lys Lys Arg Leu Tyr Ile Gin Gin Asp Gly Arg Cys Ala Tyr Thr 565 570 575 Gly Asp Val Ile Glu Leu Glu Arg Leu Phe Asp Glu Gly Tyr Cys Glu 580 585 590 Ile Asp His Ile Leu Pro Arg Ser Arg Ser Ala Asp Asp Ser Phe Ala 595 600 605 Asn Lys Val Leu Cys Leu Ala Arg Ala Asn Gin Gin Lys Thr Asp Arg 610 615 620 Thr Pro Tyr Glu Trp Phe Gly His Asp Ala Ala Arg Trp Asn Ala Phe 625 630 635 640 Glu Thr Arg Thr Ser Ala Pro Ser Asn Arg Val Arg Thr Gly Lys Gly 645 650 655 Lys Ile Asp Arg Leu Leu Lys Lys Asn Phe Asp Glu Asn Ser Glu Met 660 665 670 Ala Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Met Ala Arg Ala 675 680 685 Ile Lys Thr Tyr Cys Glu Gin Tyr Trp Val Phe Lys Asn Ser His Thr 690 695 700 Lys Ala Pro Val Gin Val Arg Ser Gly Lys Leu Thr Ser Val Leu Arg 705 710 715 720 Tyr Gin Trp Gly Leu Glu Ser Lys Asp Arg Glu Ser His Thr His His 725 730 735 Ala Val Asp Ala Ile Ile Ile Ala Phe Ser Thr Gin Gly Met Val Gin 740 745 750 Page 49 of 3790 Page 50 of 3790 1055 Phe Phe Ser Phe Thr Asp Ser Leu Asp Asn Ser Gin Ser Gly Thr Val 20 25 30 Ile Tyr Asp Glu 35 Ser Phe Val Leu Ser Gin Val Gly Arg Arg 45 Ser Lys Arg His 50 Ser Lys Arg Asn Asn 55 Leu Arg Asn Lys Leu Val 60 Lys Arg Leu Phe Leu Leu 65 Ile Leu Gin Glu His His Gly Leu Ser 70 75 Ile Asp Val Leu 80 Pro Asp Glu Ile Arg Gly Leu Phe Asn Lys Arg Gly Tyr Thr 85 90 Tyr Ala 95 Gly Phe Glu Leu Asp Glu 100 Lys Lys Lys Asp Ala Leu Glu 105 Ser Asp Thr 110 Leu Lys Glu Phe Leu 115 Ser Glu Lys 120 Leu Gin Ser Ile Asp Arg Asp Ser 125 Asp Val 130 Glu Asp Phe Leu Asn Gin 135 Ile Ala Ser Asn Ala Glu Ser Phe 140 Lys Asp Tyr Lys Lys Gly Phe Glu Ala Val Phe Ala Ser Ala Thr His 145 150 155 160 Page 51 of 3790 Ser Pro Asn Lys Lys Leu Glu Leu Lys Asp Glu Leu Lys Ser Glu Tyr 165 170 175 Gly Glu Asn Ala Lys Glu Leu Leu Ala Gly Leu Arg Val Thr Lys Glu 180 185 190 Ile Leu Asp Glu Phe Asp Lys Gin Glu Asn Gin Gly Asn Leu Pro Arg 195 200 205 Ala Lys Tyr Phe Glu Glu Leu Gly Glu Tyr Ile Ala Thr Asn Glu Lys 210 215 220 Val Lys Ser Phe Phe Asp Ser Asn Ser Leu Lys Leu Thr Asp Met Thr 225 230 235 240 Lys Leu Ile Gly Asn Ile Ser Asn Tyr Gin Leu Lys Glu Leu Arg Arg 245 250 255 Tyr Phe Asn Asp Lys Glu Met Glu Lys Gly Asp Ile Trp Ile Pro Asn 260 265 270 Lys Leu His Lys Ile Thr Glu Arg Phe Val Arg Ser Trp His Pro Lys 275 280 285 Asn Asp Ala Asp Arg Gin Arg Arg Ala Glu Leu Met Lys Asp Leu Lys 290 295 300 Ser Lys Glu Ile Met Glu Leu Leu Thr Thr Thr Glu Pro Val Met Thr 305 310 315 320 Ile Pro Pro Tyr Asp Asp Met Asn Asn Arg Gly Ala Val Lys Cys Gin 325 330 335 Thr Leu Arg Leu Asn Glu Glu Tyr Leu Asp Lys His Leu Pro Asn Trp 340 345 350 Arg Asp Ile Ala Lys Arg Leu Asn His Gly Lys Phe Asn Asp Asp Leu 355 360 365 Ala Asp Ser Thr Val Lys Gly Tyr Ser Glu Asp Ser Thr Leu Leu His 370 375 380 Arg Leu Leu Asp Thr Ser Lys Glu Ile Asp Ile Tyr Glu Leu Arg Gly 385 390 395 400 Lys Lys Pro Asn Glu Leu Leu Val Lys Thr Leu Gly Gin Ser Asp Ala Page 53 of 3790 Leu Ala Lys Ile Lys Ala Lys Glu Leu Glu Gly Met Glu Ala Lys Glu 660 665 670 Ile Lys Val Pro Ile Ile Leu Glu Gin Asn Ala Phe Glu Tyr Glu Glu 675 680 685 Ser Leu Arg Lys Ser Lys Thr Gly Ser Asn Asp Arg Val Ile Asn Ser 690 695 700 Lys Lys Asp Arg Asp Gly Lys Lys Leu Ala Lys Ala Lys Glu Asn Ala 705 710 715 720 Glu Asp Arg Leu Lys Asp Lys Asp Lys Arg Ile Lys Ala Phe Ser Ser 725 730 735 Gly Ile Cys Pro Tyr Cys Gly Asp Thr Ile Gly Asp Asp Gly Glu Ile 740 745 750 Asp His Ile Leu Pro Arg Ser His Thr Leu Lys Ile Tyr Gly Thr Val 755 760 765 Phe Asn Pro Glu Gly Asn Leu Ile Tyr Val His Gin Lys Cys Asn Gin 770 775 780 Ala Lys Ala Asp Ser Ile Tyr Lys Leu Ser Asp Ile Lys Ala Gly Val 785 790 795 800 Ser Ala Gin Trp Ile Glu Glu Gin Val Ala Asn Ile Lys Gly Tyr Lys 805 810 815 Thr Phe Ser Val Leu Ser Ala Glu Gin Gin Lys Ala Phe Arg Tyr Ala 820 825 830 Leu Phe Leu Gin Asn Asp Asn Glu Ala Tyr Lys Lys Val Val Asp Trp 835 840 845 Leu Arg Thr Asp Gin Ser Ala Arg Val Asn Gly Thr Gin Lys Tyr Leu 850 855 860 Ala Lys Lys Ile Gin Glu Lys Leu Thr Lys Met Leu Pro Asn Lys His 865 870 875 880 Leu Ser Phe Glu Phe Ile Leu Ala Asp Ala Thr Glu Val Ser Glu Leu 885 890 895 Arg Arg Gin Tyr Ala Arg Gin Asn Pro Leu Leu Ala Lys Ala Glu Lys 900 905 910 Page 54 of 3790 Page 55 of 3790 Ser Asn Ile Val Val Arg Lys Asn Ala Ala Asp Phe Thr Leu Ser Page 56 of 3790 1385 1390 1395 Phe Arg Ser Glu His Ile Gin Lys Leu Leu Lys 1400 1405 12 1374 PRT Fusobacterium nucleatum 12 Met Lys Lys Gin Lys Phe Ser Asp 1 5 Tyr Tyr Leu Gly Phe Asp Ile Gly 10 15 Thr Asn Ser Val Gly Trp Cys Val 20 Thr Asp Leu Asp Tyr Asn Val Leu 25 30 Arg Phe Asn Lys Lys Asp Met Trp 35 40 Gly Ser Arg Leu Phe Asp Glu Ala 45 Lys Thr Ala Ala Glu Arg Arg Val 50 55 Gin Arg Asn Ser Arg Arg Arg Leu 60 Lys Arg Arg Lys Trp Arg Leu Asn 65 70 Leu Leu Glu Glu Ile Phe Ser Asp 75 80 Glu Ile Met Lys Ile Asp Ser Asn 85 Phe Phe Arg Arg Leu Lys Glu Ser 90 95 Ser Leu Trp Leu Glu Asp Lys Asn 100 Ser Lys Glu Lys Phe Thr Leu Phe 105 110 Asn Asp Asp Asn Tyr Lys Asp Tyr 115 120 Asp Phe Tyr Lys Gin Tyr Pro Thr 125 Ile Phe His Leu Arg Asp Glu Leu 130 135 Ile Lys Asn Pro Glu Lys Lys Asp 140 Ile Arg Leu Ile Tyr Leu Ala Leu 145 150 His Ser Ile Phe Lys Ser Arg Gly 155 160 His Phe Leu Phe Glu Gly Gin Asn 165 Leu Lys Glu Ile Lys Asn Phe Glu 170 175 Thr Leu Tyr Asn Asn Leu Ile Ser 180 Phe Leu Glu Asp Asn Gly Ile Asn 185 190 Lys Ser Ile Asp Lys Asp Asn Ile Glu Lys Leu Glu Lys Ile Ile Cys Page 57 of 3790 195 200 205 Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Gly Ile 210 215 220 Phe Asn Ser Asp Lys Gin Leu Val Ala Ile Phe Lys Leu Ser Val Gly 225 230 235 240 Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 245 250 255 Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gin Ile Tyr Glu 260 265 270 Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 275 280 285 Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 290 295 300 Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 305 310 315 320 Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 325 330 335 Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 340 345 350 Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Asp Lys Lys Glu Val 355 360 365 Val Glu Lys Ser Arg Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 370 375 380 Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Thr Ile 385 390 395 400 Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 405 410 415 Gin Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gin Ile His Glu Val 420 425 430 Glu Leu Glu Lys Ile Leu Glu Asn Gin Ser Lys Tyr Tyr Asp Phe Leu 435 440 445 Page 59 of 3790 Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 705 710 715 720 Phe Thr Leu Gin Glu Ser Ile Asp Asn Glu Asn Lys Glu Met Asn Glu 725 730 735 Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 740 745 750 Lys Arg Ala Ile Leu Gin Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 755 760 765 Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 770 775 780 Gly Asp Glu Ser Met Lys Asn Lys Lys Ile Pro Ala Arg Gin Glu Gin 785 790 795 800 Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 805 810 815 Ile Asp Ile Lys Glu Met Lys Asn Ser Leu Ser Ser Tyr Asp Asn Asn 820 825 830 Ser Leu Arg Gin Lys Lys Leu Tyr Leu Tyr Tyr Leu Gin Phe Gly Lys 835 840 845 Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gin Asn 850 855 860 Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 865 870 875 880 Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 885 890 895 Ala Glu Lys Ser Asn Glu Tyr Pro Val Lys Lys Glu Ile Gin Glu Lys 900 905 910 Met Lys Ser Phe Trp Arg Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 915 920 925 Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Asp Phe Glu Leu Arg Gly 930 935 940 Phe Met Ala Arg Gin Leu Val Asn Val Arg Gin Thr Thr Lys Glu Val 945 950 955 960 Page 60 of 3790 Thr Phe Thr Gly Val Asp Ser Asn Lys Lys Val Glu Leu Lys Asn Page 61 of 3790 1370 13 1084 PRT Corynebacterium diphtheriae 13 Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 15 10 15 Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser Page 64 of 3790 Met Gin Glu Lys Leu Asn Val Gin Gly Lys Pro Ser Arg Ala Asp Leu 530 535 540 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 545 550 555 560 Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 565 570 575 Arg Ala Gly Gin Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 580 585 590 Cys His Arg Cys Asn Gin Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 595 600 605 Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 610 615 620 Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 625 630 635 640 Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gin Arg Ala Thr Met 645 650 655 Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 660 665 670 Asn Glu Leu Arg Ser Arg Val Ala Gin His Phe Ala Ser His Gly Thr 675 680 685 Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 690 695 700 Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 705 710 715 720 Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 725 730 735 Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 740 745 750 Gin Ser Gin Ala His Arg Gin Glu Ala Pro Gin Trp Arg Glu Phe Thr 755 760 765 Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gin Lys 770 775 780 Page 65 of 3790 Lys Ala Val 995 Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 1000 1005 Gly Phe Phe Ser Pro Ser Lys Leu Arg Leu Arg Pro Leu Gin Met 1010 1015 1020 Ser Lys Glu Gly Ile Lys Lys Glu Ser Ala Pro Glu Leu Ser Lys Page 66 of 3790 1025 1030 1035 Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His Page 69 of 3790 Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gin 660 665 670 Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 675 680 685 Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 690 695 700 Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gin Asn Asn Leu Met 705 710 715 720 Glu Leu Leu Ser Ser Glu Phe Thr Phe Thr Glu Asn Ile Lys Lys Ile 725 730 735 Asn Ser Gly Phe Glu Asp Ala Glu Lys Gin Phe Ser Tyr Asp Gly Leu 740 745 750 Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gin 755 760 765 Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gin Ala Pro Pro 770 775 780 Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 785 790 795 800 Arg Thr Lys Thr Arg Leu Lys Ile Leu Gin Asp Leu Tyr Asn Asn Cys 805 810 815 Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 820 825 830 Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 835 840 845 Leu Tyr Tyr Thr Gin Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 850 855 860 Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 865 870 875 880 Tyr Pro Gin Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 885 890 895 Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 900 905 910 Page 70 of 3790 Lys Gly Asn Lys Ile Arg Ser Leu Glu Thr Ile Pro Leu Tyr Leu Page 71 of 3790 1145 1150 1155 Ile Ser Ser Leu Asp Asn Cys Ile Leu Ile Tyr Gin Ser Ile Thr 1370 1375 1380 Page 72 of 3790 Gly Ile Phe Glu Lys Arg Ile Asp Leu Leu Lys Val Page 74 of 3790 Gin Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 465 470 475 480 Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 485 490 495 Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 500 505 510 Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Met Val Tyr Asn 515 520 525 Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gin Gly Lys Thr Asn Tyr 530 535 540 Phe Ser Gly Arg Glu Lys Gin Gin Val Phe Asn Asp Leu Phe Lys Gin 545 550 555 560 Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 565 570 575 Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 580 585 590 Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gin 595 600 605 Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 610 615 620 Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys Glu Gin Leu 625 630 635 640 Gin Gin Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys Lys Leu Glu 645 650 655 Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 660 665 670 Gly Ile Arg Glu Lys Gin Ser His Leu Thr Ile Leu Asp Tyr Leu Met 675 680 685 Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gin Leu Ile Asn Asp Ser 690 695 700 Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin Val Ser Thr Thr 705 710 715 720 Page 75 of 3790 Asp Lys Asp Leu Gin Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 725 730 735 Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val 740 745 750 Ser Ile Met Gly Tyr Pro Pro Gin Thr Ile Val Val Glu Met Ala Arg 755 760 765 Glu Asn Gin Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 770 775 780 Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys 785 790 795 800 Glu His Pro Thr Asp Asn Gin Glu Leu Lys Asn Asn Arg Leu Tyr Leu 805 810 815 Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Gin Glu Leu Asp 820 825 830 Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gin Ser 835 840 845 Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Ser Ser Ala 850 855 860 Gly Asn Arg Glu Lys Gly Gly Asp Val Pro Pro Leu Glu Ile Val Arg 865 870 875 880 Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gin Gly Asn Leu Met Ser 885 890 895 Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 900 905 910 Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gin Leu Val Glu Thr Arg 915 920 925 Gin Ile 930 Thr Lys Asn Val Ala Asn 935 Ile Leu Tyr Gin Arg Phe Asn 940 Lys Glu Thr Asp Asn His 945 Gly Asn Thr Met 950 Glu Gin Val Arg 955 Ile Val Thr 960 Leu Lys Ser Ala Leu Val Ser Gin Phe Arg Lys Gin Phe Gin Leu Tyr 965 975 Page 76 of 3790 970 Page 77 of 3790 16 1236 PRT Mycoplasma mobile 16 Met Tyr Phe Tyr Lys Asn Lys Glu Asn Lys Leu Asn Lys Lys Val Val 15 10 15 Leu Gly Leu Asp Leu Gly Ile Ala Ser Val Gly Trp Cys Leu Thr Asp 20 25 30 Ile Ser Gin Lys Glu Asp Asn Lys Phe Pro Ile Ile Leu His Gly Val 35 40 45 Arg Leu Phe 50 Glu Thr Val Asp Asp 55 Ser Asp Asp Lys Leu Leu Asn Glu Thr Arg Arg Lys Lys Arg Gly Gin Arg Arg Arg Asn Arg Arg Leu Phe 65 70 75 80 Page 79 of 3790 Asn Lys Leu Thr Asp Trp Lys His Lys Asn Glu Tyr Ile Ser Glu Arg 340 345 350 Leu Lys Arg Lys Ile Leu Leu Ser Arg Phe Leu Asn Lys Asp Ser Lys 355 360 365 Ser Ala Val Glu Lys Ile Leu Lys Glu Glu Asn Ile Lys Phe Glu Asn 370 375 380 Leu Ser Glu Ile Ala Tyr Asn Lys Asp Asp Asn Lys Ile Asn Leu Pro 385 390 395 400 Ile Ile Asn Ala Tyr His Ser Leu Thr Thr Ile Phe Lys Lys His Leu 405 410 415 Ile Asn Phe Glu Asn Tyr Leu Ile Ser Asn Glu Asn Asp Leu Ser Lys 420 425 430 Leu Met Ser Phe Tyr Lys Gin Gin Ser Glu Lys Leu Phe Val Pro Asn 435 440 445 Glu Lys Gly Ser Tyr Glu Ile Asn Gin Asn Asn Asn Val Leu His Ile 450 455 460 Phe Asp Ala Ile Ser Asn Ile Leu Asn Lys Phe Ser Thr Ile Gin Asp 465 470 475 480 Arg Ile Arg Ile Leu Glu Gly Tyr Phe Glu Phe Ser Asn Leu Lys Lys 485 490 495 Asp Val Lys Ser Ser Glu Ile Tyr Ser Glu Ile Ala Lys Leu Arg Glu 500 505 510 Phe Ser Gly Thr Ser Ser Leu Ser Phe Gly Ala Tyr Tyr Lys Phe Ile 515 520 525 Pro Asn Leu Ile Ser Glu Gly Ser Lys Asn Tyr Ser Thr Ile Ser Tyr 530 535 540 Glu Glu Lys Ala Leu Gin Asn Gin Lys Asn Asn Phe Ser His Ser Asn 545 550 555 560 Leu Phe Glu Lys Thr Trp Val Glu Asp Leu Ile Ala Ser Pro Thr Val 565 570 575 Lys Arg Ser Leu Arg Gin Thr Met Asn Leu Leu Lys Glu Ile Phe Lys 580 585 590 Page 80 of 3790 Tyr Ser Glu Lys Asn Asn Leu Glu Ile Glu Lys Ile Val Val Glu Val 595 600 605 Thr Arg Ser Ser Asn Asn Lys His Glu Arg Lys Lys Ile Glu Gly Ile 610 615 620 Asn Lys Tyr Arg Lys Glu Lys Tyr Glu Glu Leu Lys Lys Val Tyr Asp 625 630 635 640 Leu Pro Asn Glu Asn Thr Thr Leu Leu Lys Lys Leu Trp Leu Leu Arg 645 650 655 Gin Gin Gin Gly Tyr Asp Ala Tyr Ser Leu Arg Lys Ile Glu Ala Asn 660 665 670 Asp Val Ile Asn Lys Pro Trp Asn Tyr Asp Ile Asp His Ile Val Pro 675 680 685 Arg Ser Ile Ser Phe Asp Asp Ser Phe Ser Asn Leu Val Ile Val Asn 690 695 700 Lys Leu Asp Asn Ala Lys Lys Ser Asn Asp Leu Ser Ala Lys Gin Phe 705 710 715 720 Ile Glu Lys Ile Tyr Gly Ile Glu Lys Leu Lys Glu Ala Lys Glu Asn 725 730 735 Trp Gly Asn Trp Tyr Leu Arg Asn Ala Asn Gly Lys Ala Phe Asn Asp 740 745 750 Lys Gly Lys Phe Ile Lys Leu Tyr Thr Ile Asp Asn Leu Asp Glu Phe 755 760 765 Asp Asn Ser Asp Phe Ile Asn Arg Asn Leu Ser Asp Thr Ser Tyr Ile 770 775 780 Thr Asn Ala Leu Val Asn His Leu Thr Phe Ser Asn Ser Lys Tyr Lys 785 790 795 800 Tyr Ser Val Val Ser Val Asn Gly Lys Gin Thr Ser Asn Leu Arg Asn 805 810 815 Gin Ile Ala Phe Val Gly Ile Lys Asn Asn Lys Glu Thr Glu Arg Glu 820 825 830 Trp Lys Arg Pro Glu Gly Phe Lys Ser Ile Asn Ser Asn Asp Phe Leu Page 81 of 3790 Phe Lys Ile Ile Arg Lys Ile Arg Tyr Ile Lys Phe Ser Ser Glu 1070 1075 1080 Page 82 of 3790 Phe Lys Lys 1235 17 1372 PRT Legionella pneumophila 17 Met Glu Ser Ser Gin Ile Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly 15 10 15 Lys Phe Thr Gly Val Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 20 25 30 Pro Asn His Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 35 40 45 Page 84 of 3790 Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gin Ser Leu Leu 305 310 315 320 Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 325 330 335 Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 340 345 350 His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gin 355 360 365 Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gin Arg Tyr Leu Asp Leu Asn 370 375 380 Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gin Leu Ser Phe Leu Gly 385 390 395 400 Gin Gly Lys Gin Leu Pro Ala Asn Leu Ile Glu Thr Gin Lys Glu Met 405 410 415 Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gin Ile Ala 420 425 430 Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gin Gly Ile Trp Phe 435 440 445 Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 450 455 460 Lys Gin Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 465 470 475 480 Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Ile Phe Trp Asn 485 490 495 Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 500 505 510 Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 515 520 525 Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 530 535 540 Ile Ile Gin Thr Ile Pro Asp Ile Ile Gin Ala Ile Gin Ser His Leu 545 550 555 560 Page 85 of 3790 Gly His Asn Asp Ser Gin Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 565 570 575 Ser Gin Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 580 585 590 Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gin Lys Thr 595 600 605 Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 610 615 620 Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gin Arg Leu Ala 625 630 635 640 Tyr Glu Ile Ala Met Ala Lys Trp Glu Gin Ile Lys His Ile Pro Asp 645 650 655 Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gin Asn Arg Phe Glu 660 665 670 Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Ser Ser Ser Asp Lys Thr 675 680 685 Leu Glu Gin Ala Ile Glu Lys Gin Asn Ile Gin Trp Glu Glu Lys Phe 690 695 700 Gin Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 705 710 715 720 Ser Ile Gly Gly Gin Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 725 730 735 Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Val Asn Leu Ile 740 745 750 Tyr Cys Ser Ser Gin Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 755 760 765 Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gin Phe Gly Thr Asp 770 775 780 Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gin Asn Val Ala Asn Ile 785 790 795 800 Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gin Gin Lys Ala 805 815 Page 86 of 3790 810 Page 87 of 3790 Page 88 of 3790 Lys Lys Gin Pro 1370 18 1122 PRT Streptococcus thermophilus 18 Page 89 of 3790 Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser Lys 130 135 140 Gin Leu Glu Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Tyr Gin 145 150 155 160 Thr Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 165 170 175 Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 180 185 190 Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Ser Gin Ile Thr 195 200 205 Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Arg Thr Asn Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gin Lys Asn Gin Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu Lys Val Met Gly Pro Ala Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 325 330 335 His Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 340 345 350 Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gin Met Asp 355 360 365 Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 370 375 380 Page 90 of 3790 Arg Glu Gly Ile Gin Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 385 390 395 400 Phe Ser Gin Lys Gin Val Asp Glu Leu Val Gin Phe Arg Lys Ala Asn 405 410 415 Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 420 425 430 Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr 435 440 445 Ile Leu Thr Arg Leu Gly Lys Gin Lys Thr Thr Ser Ser Ser Asn Lys 450 455 460 Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Val Asn Ala Ala 485 490 495 Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 500 505 510 Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Lys Ile Gin Lys 515 520 525 Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gin 530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 545 550 555 560 Gin Leu Ala Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 580 585 590 Asn Gin Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu Asp Ser Met Asp Asp Ala Glu Gly Asp Lys Pro Lys Leu Asp Phe 1115 1120 Page 93 of 3790 19 1128 PRT Streptococcus thermophilus 19 Met Ser Asp Leu Val Leu Gly Leu 1 5 Asp Ile Gly Ile Gly Ser Val Gly 10 15 Val Gly Ile Leu Asn Lys Val Thr 20 Gly Glu Ile Ile His Lys Asn Ser 25 30 Arg Ile Phe Pro Ala Ala Gin Ala 35 40 Glu Asn Asn Leu Val Arg Arg Thr 45 Asn Arg Gin Gly Arg Arg Leu Thr 50 55 Arg Arg Lys Lys His Arg Ile Val 60 Arg Leu Asn Arg Leu Phe Glu Glu 65 70 Ser Gly Leu Ile Thr Asp Phe Thr 75 80 Lys Ile Ser Ile Asn Leu Asn Pro 85 Tyr Gin Leu Arg Val Lys Gly Leu 90 95 Thr Asp Glu Leu Ser Asn Glu Glu 100 Leu Phe Ile Ala Leu Lys Asn Met 105 110 Val Lys His Arg Gly Ile Ser Tyr 115 120 Leu Asp Asp Ala Ser Asp Asp Gly 125 Asn Ser Ser Val Gly Asp Tyr Ala 130 135 Gin Ile Val Lys Glu Asn Ser Lys 140 Gin Leu Glu Thr Lys Thr Pro Gly 145 150 Gin Ile Gin Leu Glu Arg Tyr Gin 155 160 Thr Tyr Gly Gin Leu Arg Gly Asp 165 Phe Thr Val Glu Lys Asp Gly Lys 170 175 Lys His Arg Leu Ile Asn Val Phe 180 Pro Thr Ser Ala Tyr Arg Ser Glu 185 190 Ala Leu Arg Ile Leu Gin Thr Gin 195 200 Gin Glu Phe Asn Pro Gin Ile Thr 205 Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Page 94 of 3790 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gin Lys Asn Gin Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 325 330 335 Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 340 345 350 Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gin Met Asp 355 360 365 Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Gin Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 385 390 395 400 Phe Ser Gin Lys Gin Val Asp Glu Leu Val Gin Phe Arg Lys Ala Asn 405 410 415 Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 420 425 430 Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr 435 440 445 Ile Leu 450 Thr Arg Leu Gly Lys 455 Gin Lys Arg Leu Arg Leu 460 Gin Ile Lys Gin Asn Ile Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr 465 470 475 480 Page 95 of 3790 Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gin Ala Ile 485 490 495 Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 500 505 510 Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 515 520 525 Ile Gin Lys Ile Gin Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 530 535 540 Leu Lys Ala Ala Asn Gin Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 545 550 555 560 Val Phe His Gly His Lys Gin Leu Ala Thr Lys Ile Arg Leu Trp His 565 570 575 Gin Gin Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 580 585 590 Asp Leu Ile Asn Asn Pro Asn Gin Phe Glu Val Asp His Ile Leu Pro 595 600 605 Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 610 615 620 Ala Thr Ala Asn Gin Glu Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu 625 630 635 640 Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 645 650 655 Arg Glu Ser Lys Thr Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 660 665 670 Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 675 680 685 Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 690 695 700 Gin Glu His Phe Arg Ala His Lys Ile Asp Thr Lys Val Ser Val Val 705 710 715 720 Arg Gly Gin Phe Thr Ser Gin Leu Arg Arg His Trp Gly Ile Glu Lys Page 97 of 3790 Tyr Phe Asn Lys Ala Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr 980 985 990 Ala Asp Leu Gin Phe Glu Lys Gly Thr Gly Thr Tyr Lys Ile Ser Gin 995 1000 1005 20 1123 PRT Francisella tularensis 20 Met Asn Val Lys Ile Leu Pro Ile Ala Ile Asp Leu Asp Val Lys Asn 15 10 15 Thr Gly Val Phe Ser Ala Phe Tyr Gin Lys Gly Thr Ser Leu Glu Lys 20 25 30 Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 35 40 45 Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Lys Arg Arg Gly 50 55 60 Page 99 of 3790 Asn Val Leu Asp Glu Asn Asn His Gin Glu Gly Tyr Leu Lys Asn Phe 325 330 335 Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 340 345 350 Leu Val Asn Leu Val Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 355 360 365 Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 370 375 380 Glu Gin Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 385 390 395 400 Arg Val Gly Val Lys Asp Gin Asp Lys Lys Asp Gly Ala Lys Tyr Ser 405 410 415 Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gin Lys Val Thr Lys Ala Gly 420 425 430 Leu Ile Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 435 440 445 Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gin Ser Leu Ile 450 455 460 Leu Asn Pro Lys Phe Leu Asp Asn Gin Tyr Pro Asn Trp Gin Gin Tyr 465 470 475 480 Leu Gin Glu Leu Lys Lys Leu Gin Ser Ile Gin Asp Tyr Leu Asp Ser 485 490 495 Phe Glu Thr Asp Leu Lys Asp Leu Lys Ser Ser Lys Asp Gin Pro Tyr 500 505 510 Phe Val Glu Tyr Lys Ser Ser Asn Gin Gin Met Ala Ser Gly Gin Arg 515 520 525 Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gin Phe Ile Phe Asp Arg 530 535 540 Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gin Ala 545 550 555 560 Lys Lys Leu Lys Gin Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 565 570 575 Page 100 of 3790 Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gin Leu Ser Gin Ile 580 585 590 Leu Lys Ser Gin His Thr Asn Gly Ile Phe Glu Gin Gly Thr Phe Leu 595 600 605 His Leu Val Cys Lys Tyr Tyr Lys Gin Arg Gin Arg Ala Arg Asp Ser 610 615 620 Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu Asp Lys 625 630 635 640 Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asn Asn Gin Leu Leu Thr Tyr 645 650 655 Cys Asn His Lys Pro Arg Gin Lys Arg Tyr Gin Leu Leu Asn Asp Leu 660 665 670 Ala Gly Val Leu Gin Val Ser Arg Asn Gin Leu Leu Ser Ser Val Glu 675 680 685 Glu Trp Phe Gin Gin Ala Gin Arg Val Gly Glu Ile Ser Lys Ser Gin 690 695 700 Asp Glu Gin Ile Phe Glu Trp Leu Lys Ser Phe Lys Ile Ala Ser Tyr 705 710 715 720 Cys Lys Ala Ala Val Glu Met Gin Lys Gin Tyr Arg Gly Thr Leu Lys 725 730 735 Asn Ala Ile Gin Thr Ala Ile Phe Arg Gin Ser Glu Asn Ile Asn Lys 740 745 750 Asn Lys Asn Thr Gly Asn Gin Gin Gin Ala Leu Ser Glu Asn Ser Lys 755 760 765 Asp Val Lys Ser Leu Thr Ala Asp Glu Lys Lys Leu Leu Lys Leu Ile 770 775 780 Glu Asn Ile Ala Lys Ala Ser Gin Lys Ile Gly Glu Ser Leu Gly Leu 785 790 795 800 Asn Asp Lys Gin Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gin 805 810 815 Ile Gin Gin Ile Ala Phe Ala Lys Arg Lys Gly Asn Ala Asn Thr Cys 820 Page 101 of 3790 825 830 Arg Val Lys Leu Asp Tyr Val Ile Asp Asp Asp Ser Lys Ile Asn 1055 1060 1065 Page 102 of 3790 Asn Asn Lys Ser Arg Tyr Pro Asp Lys 1080 Thr Ile Ile Glu Phe Glu Ser 1095 Glu Met Leu Gly Met Thr Leu 1110 5 Leu Gly Thr Asn Ser Ile Gly Trp 10 15 Ala Leu Val Asn Glu Ala Glu Asn 20 Lys Asp Glu Arg Ser Ser Ile Val 25 30 Lys Leu Gly Val Arg Val Asn Pro 35 40 Leu Thr Val Asp Glu Leu Thr Asn 45 Phe Glu Lys Gly Lys Ser Ile Thr 50 55 Thr Asn Ala Asp Arg Thr Leu Lys 60 Arg Gly Met Arg Arg Asn Leu Gin 65 70 Arg Tyr Lys Leu Arg Arg Glu Thr 75 80 Leu Thr Glu Val Leu Lys Glu His 85 Lys Leu Ile Thr Glu Asp Thr Ile 90 95 Leu Ser Glu Asn Gly Asn Arg Thr 100 Thr Phe Glu Thr Tyr Arg Leu Arg 105 110 Ala Lys Ala Val Thr Glu Glu Ile 115 120 Ser Leu Glu Glu Phe Ala Arg Val 125 Leu Leu Met Ile Asn Lys Lys Arg 130 135 Gly Tyr Lys Ser Ser Arg Lys Ala 140 Lys Gly Val Glu Glu Gly Thr Leu 145 150 Ile Asp Gly Met Asp Ile Ala Arg 155 160 Page 103 of 3790 Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gin Leu 165 170 175 Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 180 185 190 Gin Asn Glu Leu Asp Arg Ile Trp Glu Lys Gin Lys Glu Tyr Tyr Pro 195 200 205 Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 210 215 220 Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Asn 225 230 235 240 Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gin Gin Glu Arg 245 250 255 Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 260 265 270 Lys Arg Glu Asn Leu Gin Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 275 280 285 Ser Leu Glu Gin Leu Val Ile Val Phe Gin Glu Met Asn Thr Gin Ile 290 295 300 Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 305 310 315 320 Leu Tyr Phe Asn Lys Gin Thr Val Gly Gin Tyr Gin Met Glu Met Leu 325 330 335 Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gin 340 345 350 Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gin Ala Val Tyr 355 360 365 His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 370 375 380 Ile Phe Tyr Gin Arg Arg Leu Lys Ser Gin Lys Gly Leu Ile Gly Phe 385 390 395 400 Cys Glu Phe Glu Ser Arg Gin Ile Glu Val Asp Ile Asp Gly Lys Lys 405 410 415 Page 104 of 3790 Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 420 425 430 Phe Gin Glu Phe Lys Ile Trp Gin Ile Leu Asn Asn Ile Glu Val Thr 435 440 445 Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 450 455 460 Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gin Leu Glu Leu Asn Gly 465 470 475 480 Ser Arg Arg Leu Cys Gin Glu Glu Lys Glu Leu Leu Ala Gin Glu Leu 485 490 495 Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 500 505 510 Asp Asn Pro Gin Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 515 520 525 Lys Thr Gly Tyr Ala Leu Phe Gin Ala Tyr Ser Lys Met Ile Glu Met 530 535 540 Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 545 550 555 560 Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 565 570 575 Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gin Pro Tyr Tyr Lys 580 585 590 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 595 600 605 Asn Gly Arg Leu Ile Gin Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 610 615 620 Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gin Asp Asp Tyr Gly 625 630 635 640 Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 645 650 655 Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 660 665 670 Page 105 of 3790 Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 675 680 685 Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 690 695 700 Lys Ile Leu Asn Gin Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 705 710 715 720 Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 725 730 735 Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gin Thr 740 745 750 Thr Lys Ala His Glu Glu Tyr Lys Thr Leu Leu Gin Thr Glu Phe Gly 755 760 765 Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 770 775 780 Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 785 790 795 800 Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 805 810 815 Pro Gin Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 820 825 830 Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 835 840 845 Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 850 855 860 Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 865 870 875 880 Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gin Asp Ile Pro Asp Gly 885 890 895 Phe Ile Glu Arg Asp Leu Arg Asn Thr Gin Tyr Ile Ala Lys Lys Ala 900 905 910 Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly Page 106 of 3790 Page 107 of 3790 Page 108 of 3790 Ser Ser Ile Leu Arg Gly Ile Thr Trp Ile Asp Phe Arg Ser Ser 1400 1405 1410 Lys Gly Leu Asp Thr Ile Val Lys Val Arg Val Asn His Ile Gly 1415 1420 1425 Page 109 of 3790 Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp Glu Phe Val Ser Asn Ser 180 185 190 Phe Pro Ser Lys Lys Leu His Glu His Tyr Glu Lys Tyr Gly Phe Phe 195 200 205 Arg Gly Ser Val Lys Leu Asp Asn Lys Leu Asp Asn Lys Lys Asp Lys 210 215 220 Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser Asp Ala Lys Lys Glu Ser 225 230 235 240 Glu Glu Leu Ile Phe Ser Asn Lys Gin Trp Ile Asn Glu Ile Val Lys 245 250 255 Val Phe Glu Asn Gin Ser Tyr Leu Thr Glu Ser Phe Lys Glu Glu Tyr 260 265 270 Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe Asn Lys Gly Pro Gly Ser 275 280 285 Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe Ser Thr Asp Ile Asp Pro 290 295 300 Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn Ile Trp Asp Lys Thr Ile 305 310 315 320 Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile Arg Ala Pro Lys Asn Leu 325 330 335 Pro Ser Ala Leu Ile Phe Asn Leu Gin Asn Glu Ile Cys Thr Ile Lys 340 345 350 Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp Leu Asn Ala Glu Gin Lys 355 360 365 Ser Glu Ile Leu Lys Phe Val Phe Thr Glu Leu Phe Asn Trp Lys Asp 370 375 380 Lys Lys Tyr Ser Asp Lys Lys Phe Asn Lys Asn Leu Gin Asp Lys Ile 385 390 395 400 Lys Lys Tyr Leu Leu Asn Phe Ala Leu Glu Asn Phe Asn Leu Asn Glu 405 410 415 Glu Ile Leu Lys Asn Arg Asp Leu Glu Asn Asp Thr Val Leu Gly Leu 420 425 430 Page 110 of 3790 Lys Gly Val Lys Tyr Tyr Glu Lys Ser Asn Ala Thr Ala Asp Ala Ala 435 440 445 Leu Glu Phe Ser Ser Leu Lys Pro Leu Tyr Val Phe Ile Lys Phe Leu 450 455 460 Lys Glu Lys Lys Leu Asp Leu Asn Tyr Leu Leu Gly Leu Glu Asn Thr 465 470 475 480 Glu Ile Leu Tyr Phe Leu Asp Ser Ile Tyr Leu Ala Ile Ser Tyr Ser 485 490 495 Ser Asp Leu Lys Glu Arg Asn Glu Trp Phe Lys Lys Leu Leu Lys Glu 500 505 510 Leu Tyr Pro Lys Ile Lys Asn Asn Asn Leu Glu Ile Ile Glu Asn Val 515 520 525 Glu Asp Ile Phe Glu Ile Thr Asp Gin Glu Lys Phe Glu Ser Phe Ser 530 535 540 Lys Thr His Ser Leu Ser Arg Glu Ala Phe Asn His Ile Ile Pro Leu 545 550 555 560 Leu Leu Ser Asn Asn Glu Gly Lys Asn Tyr Glu Ser Leu Lys His Ser 565 570 575 Asn Glu Glu Leu Lys Lys Arg Thr Glu Lys Ala Glu Leu Lys Ala Gin 580 585 590 Gin Asn Gin Lys Tyr Leu Lys Asp Asn Phe Leu Lys Glu Ala Leu Val 595 600 605 Pro Leu Ser Val Lys Thr Ser Val Leu Gin Ala Ile Lys Ile Phe Asn 610 615 620 Gin Ile Ile Lys Asn Phe Gly Lys Lys Tyr Glu Ile Ser Gin Val Val 625 630 635 640 Ile Glu Met Ala Arg Glu 645 Leu Thr Lys Pro Asn Leu Glu Lys 650 Leu Leu 655 Asn Asn Ala Thr Asn 660 Ser Asn Ile Lys 665 Ile Leu Lys Glu Lys 670 Leu Asp Gin Thr Glu Lys Phe Asp Asp Phe Thr Lys Lys Lys Phe Ile Asp Lys Page 111 of 3790 675 680 685 Ile Glu Asn Ser Val Val Phe Arg Asn Lys Leu Phe Leu Trp Phe Glu 690 695 700 Gin Asp Arg Lys Asp Pro Tyr Thr Gin Leu Asp Ile Lys Ile Asn Glu 705 710 715 720 Ile Glu Asp Glu Thr Glu Ile Asp His Val Ile Pro Tyr Ser Lys Ser 725 730 735 Ala Asp Asp Ser Trp Phe Asn Lys Leu Leu Val Lys Lys Ser Thr Asn 740 745 750 Gin Leu Lys Lys Asn Lys Thr Val Trp Glu Tyr Tyr Gin Asn Glu Ser 755 760 765 Asp Pro Glu Ala Lys Trp Asn Lys Phe Val Ala Trp Ala Lys Arg Ile 770 775 780 Tyr Leu Val Gin Lys Ser Asp Lys Glu Ser Lys Asp Asn Ser Glu Lys 785 790 795 800 Asn Ser Ile Phe Lys Asn Lys Lys Pro Asn Leu Lys Phe Lys Asn Ile 805 810 815 Thr Lys Lys Leu Phe Asp Pro Tyr Lys Asp Leu Gly Phe Leu Ala Arg 820 825 830 Asn Leu Asn Asp Thr Arg Tyr Ala Thr Lys Val Phe Arg Asp Gin Leu 835 840 845 Asn Asn Tyr Ser Lys His His Ser Lys Asp Asp Glu Asn Lys Leu Phe 850 855 860 Lys Val Val Cys Met Asn Gly Ser Ile Thr Ser Phe Leu Arg Lys Ser 865 870 875 880 Met Trp Arg Lys Asn Glu Glu Gin Val Tyr Arg Phe Asn Phe Trp Lys 885 890 895 Lys Asp Arg Asp Gin Phe Phe His His Ala Val Asp Ala Ser Ile Ile 900 905 910 Ala Ile Phe Ser Leu Leu Thr Lys Thr Leu Tyr Asn Lys Leu Arg Val 915 920 925 Page 112 of 3790 Page 113 of 3790 1310 23 1368 PRT Streptococcus pyogenes 23 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val 20 Ile Thr Asp Asp Tyr Lys Val 25 Pro Ser Lys Lys 30 Phe Lys Val Leu Gly Asn 35 Thr Asp Arg 40 His Ser Ile Lys Lys Asn Leu 45 Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Page 114 of 3790 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Page 115 of 3790 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Page 117 of 3790 Page 118 of 3790 Page 119 of 3790 24 1368 PRT Streptococcus pyogenes 24 Page 120 of 3790 Met Ile Lys Phe Arg Gly His Phe 165 Leu Ile Glu Gly Asp Leu Asn Pro 170 175 Asp Asn Ser Asp Val Asp Lys Leu 180 Phe Ile Gin Leu Val Gin Thr Tyr 185 190 Asn Gin Leu Phe Glu Glu Asn Pro 195 200 Ile Asn Ala Ser Gly Val Asp Ala 205 Lys Ala Ile Leu Ser Ala Arg Leu 210 215 Ser Lys Ser Arg Arg Leu Glu Asn 220 Leu Ile Ala Gin Leu Pro Gly Glu 225 230 Lys Lys Asn Gly Leu Phe Gly Asn 235 240 Leu Ile Ala Leu Ser Leu Gly Leu 245 Thr Pro Asn Phe Lys Ser Asn Phe 250 255 Asp Leu Ala Glu Asp Ala Lys Leu 260 Gin Leu Ser Lys Asp Thr Tyr Asp 265 270 Asp Asp Leu Asp Asn Leu Leu Ala 275 280 Gin Ile Gly Asp Gin Tyr Ala Asp 285 Leu Phe Leu Ala Ala Lys Asn Leu 290 295 Ser Asp Ala Ile Leu Leu Ser Asp 300 Ile Leu Arg Val Asn Thr Glu Ile 305 310 Thr Lys Ala Pro Leu Ser Ala Ser 315 320 Met Ile Lys Arg Tyr Asp Glu His 325 His Gin Asp Leu Thr Leu Leu Lys 330 335 Ala Leu Val Arg Gin Gin Leu Pro 340 Glu Lys Tyr Lys Glu Ile Phe Phe 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala 355 360 Gly Tyr Ile Asp Gly Gly Ala Ser 365 Gin Glu Glu Phe Tyr Lys Phe Ile 370 375 Lys Pro Ile Leu Glu Lys Met Asp 380 Gly Thr Glu Glu Leu Leu Val Lys 385 390 Leu Asn Arg Glu Asp Leu Leu Arg 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu Page 121 of 3790 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Page 122 of 3790 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Page 123 of 3790 Page 124 of 3790 25 1370 PRT Streptococcus agalactiae Page 125 of 3790 25 Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 100 105 110 Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Gin Glu Glu Lys Asp Tyr 115 120 125 His Glu Lys Phe Ser Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 130 135 140 Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Ile Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Ser Lys Gin Tyr Gin Asp Phe Leu Glu Ile 180 185 190 Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gin Asn Val Asp 195 200 205 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys Tyr Page 127 of 3790 Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 530 535 540 Lys Gin Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 545 550 555 560 Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 565 570 575 Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 595 600 605 Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gin Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 625 630 635 640 Tyr Lys Asp Leu Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asp Lys Glu Ser Gin Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 675 680 685 Gly Arg Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu 690 695 700 Ser Phe Lys Ser Ile Ile Ser Lys Ala Gin Ala Gly Ser His Ser Asp 705 710 715 720 Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Page 128 of 3790 Page 129 of 3790 Met Lys Phe Leu Tyr Leu Ala Ser Arg Tyr Asn Glu Ser Lys Gly Glu Asp 1370 26 1173 PRT Rhodospirillum rubrum 26 Met Arg Pro Ile Glu Pro Trp Ile Leu Gly Leu Asp Ile Gly Thr Asp 15 10 15 Ser Leu Gly Trp Ala Val 20 Phe Ser Cys 25 Glu Glu Lys Gly Pro Pro 30 Thr Ala Lys Glu Leu Leu Gly Gly 35 Gly Val 40 Arg Leu Phe Asp 45 Ser Gly Arg Asp Ala Lys 50 Asp His Thr Ser Arg Gin Ala 55 Glu Arg 60 Gly Ala Phe Arg Arg Ala Arg Arg Gin Thr Arg Thr Trp Pro Trp Arg Arg Asp Arg Leu Page 132 of 3790 Thr Ala Arg Phe Val Glu Trp Pro Ala Leu Arg Arg Ala Leu Gly Leu 325 330 335 Lys Arg Gly Val Lys Phe Thr Ala Glu Thr Glu Arg Asn Gly Ala Lys 340 345 350 Gin Ala Ala Arg Gly Thr Ala Gly Asn Leu Thr Glu Ala Ile Leu Ala 355 360 365 Pro Leu Ile Pro Gly Trp Ser Gly Trp Asp Leu Asp Arg Lys Asp Arg 370 375 380 Val Phe Ser Asp Leu Trp Ala Ala Arg Gin Asp Arg Ser Ala Leu Leu 385 390 395 400 Ala Leu Ile Gly Asp Pro Arg Gly Pro Thr Arg Val Thr Glu Asp Glu 405 410 415 Thr Ala Glu Ala Val Ala Asp Ala Ile Gin Ile Val Leu Pro Thr Gly 420 425 430 Arg Ala Ser Leu Ser Ala Lys Ala Ala Arg Ala Ile Ala Gin Ala Met 435 440 445 Ala Pro Gly Ile Gly Tyr Asp Glu Ala Val Thr Leu Ala Leu Gly Leu 450 455 460 His His Ser His Arg Pro Arg Gin Glu Arg Leu Ala Arg Leu Pro Tyr 465 470 475 480 Tyr Ala Ala Ala Leu Pro Asp Val Gly Leu Asp Gly Asp Pro Val Gly 485 490 495 Pro Pro Pro Ala Glu Asp Asp Gly Ala Ala Ala Glu Ala Tyr Tyr Gly 500 505 510 Arg Ile Gly Asn Ile Ser Val His Ile Ala Leu Asn Glu Thr Arg Lys 515 520 525 Ile Val Asn Ala Leu Leu His Arg His Gly Pro Ile Leu Arg Leu Val 530 535 540 Met Val Glu Thr Thr Arg Glu Leu Lys Ala Gly Ala Asp Glu Arg Lys 545 550 555 560 Arg Met Ile Ala Glu Gin Ala Glu Arg Glu Arg Glu Asn Ala Glu Ile 565 570 575 Page 133 of 3790 Asp Val Glu Leu Arg Lys Ser Asp Arg Trp Met Ala Asn Ala Arg Glu 580 585 590 Arg Arg Gin Arg Val Arg Leu Ala Arg Arg Gin Asn Asn Leu Cys Pro 595 600 605 Tyr Thr Ser Thr Pro Ile Gly His Ala Asp Leu Leu Gly Asp Ala Tyr 610 615 620 Asp Ile Asp His Val Ile Pro Leu Ala Arg Gly Gly Arg Asp Ser Leu 625 630 635 640 Asp Asn Met Val Leu Cys Gin Ser Asp Ala Asn Lys Thr Lys Gly Asp 645 650 655 Lys Thr Pro Trp Glu Ala Phe His Asp Lys Pro Gly Trp Ile Ala Gin 660 665 670 Arg Asp Asp Phe Leu Ala Arg Leu Asp Pro Gin Thr Ala Lys Ala Leu 675 680 685 Ala Trp Arg Phe Ala Asp Asp Ala Gly Glu Arg Val Ala Arg Lys Ser 690 695 700 Ala Glu Asp Glu Asp Gin Gly Phe Leu Pro Arg Gin Leu Thr Asp Thr 705 710 715 720 Gly Tyr Ile Ala Arg Val Ala Leu Arg Tyr Leu Ser Leu Val Thr Asn 725 730 735 Glu Pro Asn Ala Val Val Ala Thr Asn Gly Arg Leu Thr Gly Leu Leu 740 745 750 Arg Leu Ala Trp Asp Ile Thr Pro Gly Pro Ala Pro Arg Asp Leu Leu 755 760 765 Pro Thr Pro Arg Asp Ala Leu Arg Asp Asp Thr Ala Ala Arg Arg Phe 770 775 780 Leu Asp Gly Leu Thr Pro Pro Pro Leu Ala Lys Ala Val Glu Gly Ala 785 790 795 800 Val Gin Ala Arg Leu Ala Ala Leu Gly Arg Ser Arg Val Ala Asp Ala 805 810 815 Gly Leu Ala Asp Ala Leu Gly Leu Thr Leu Ala Ser Leu Gly Gly Gly 820 825 830 Page 134 of 3790 Gin Pro Ala Pro Pro Pro Pro Pro Glu Asn Ala Arg Leu Val Met Arg Leu Arg Page 135 of 3790 1070 1075 1080 Arg Leu Ser Val Ala Ser Arg Gly Gly Pro Asp Ser Lys Glu Glu Ala Page 136 of 3790 115 120 125 Gly Tyr Asp Phe Tyr Pro Glu Arg Ala His Leu Glu Asp Glu Phe His 130 135 140 Ala Leu Trp Ser Ala Gin Ala Ala Phe His Pro Asp Leu Thr Cys Glu 145 150 155 160 Leu Arg Asp Val Val Phe Glu Lys Ile Phe Tyr Gin Arg Pro Leu Lys 165 170 175 Glu Pro Lys Val Gly Leu Cys Leu Phe Thr Ala Glu Glu Arg Leu Pro 180 185 190 Lys Ala His Pro Leu Thr Gly Arg Arg Val Leu Tyr Glu Thr Val Asn 195 200 205 Gin Leu Arg Val Thr Ala Asp Gly Arg Thr Thr Arg Pro Leu Thr Leu 210 215 220 Glu Glu Arg Asp Met Ile Val Tyr Ala Leu Asp Asn Lys Lys Pro Val 225 230 235 240 Lys Ser Leu Ser Ser Met His Leu Lys Leu Val Ala Leu Gly Lys Leu 245 250 255 Val Lys Leu Lys Asp Gly Glu Arg Phe Thr Leu Glu Ser Gly Val Arg 260 265 270 Asp Ala Ile Ala Cys Asp Pro Ile Arg Ala Thr Met Gly His Pro Asp 275 280 285 Gly Phe Gly Pro Ala Trp Ser Arg Leu Asp Trp Gin Ala Gin Trp Ala 290 295 300 Leu Ile Glu Lys Leu Arg Gin Val Gin Ser Asp Asp Asp Phe Ala Ser 305 310 315 320 Leu Val Ala Trp Leu Gly Ala Thr His Asn Leu Ser Glu Asp His Ala 325 330 335 Lys Arg Val Ala Asn Leu His Leu Pro Glu Gly Tyr Gly Arg Leu Gly 340 345 350 Leu Thr Ala Thr Glu Ala Ile Leu Cys Asn Leu Lys Ala Glu Val Cys 355 360 365 Page 138 of 3790 Ile Ser Arg Ala Tyr Leu Asp Thr Leu Phe Thr Glu Gly Gly His Val 625 630 635 640 Trp Val Val Pro Gly Arg Met Thr Glu Met Leu Arg Arg His Trp Gly 645 650 655 Leu Asn Ala Leu Leu Ser Asp Lys Asp Arg Gly Ala Gly Lys Val Lys 660 665 670 Asn Arg Thr Asp His Arg His His Ala Ile Asp Ala Ala Val Ile Ala 675 680 685 Ala Thr Asp His Ser Leu Val Asn Arg Ile Ser Lys Ala Ala Gly Gin 690 695 700 Gly Glu Ser Ala Gly Gin Ser Ala Glu Leu Ile Ala Arg Asp Thr Pro 705 710 715 720 Glu Pro Trp Glu Gly Phe Arg Asn Asp Ile Ser Ala Gin Ile Ala Arg 725 730 735 Ile Val Val Ser His Arg Ala Asp His Gly Arg Ile Asp Val Glu Gly 740 745 750 Arg Lys His Gly Lys Asp Ser Thr Ala Gly Arg Leu His Asn Asp Thr 755 760 765 Ala Tyr Gly Ile Val Asp Asp His Thr Val Val Ser Arg Thr Pro Leu 770 775 780 Leu Ser Leu Lys Pro Gly Asp Ile Glu Val Thr Thr Lys Gly Lys Asn 785 790 795 800 Ile Arg Asp Thr Gin Leu Gin Lys Ala Leu Ser Val Ala Thr Thr Gly 805 810 815 Lys Asp Gly Lys Gly Phe Glu Glu Ala Leu Arg Asn Phe Ala Glu Lys 820 825 830 Glu Gly Pro Tyr Gin Gly Ile Arg Arg Val Arg Leu Ile Glu Thr Leu 835 840 845 Gin Ser Ser Ala Arg Val Glu Val Gly Ser Asp Glu Asp Gly Gin Pro 850 855 860 Leu Lys Ala Tyr Lys Gly Asp Ser Asn His Cys Tyr Asp Leu Trp Lys 865 870 875 880 Page 139 of 3790 Page 140 of 3790 Pro Tyr Glu Ile Gly Arg Ile Leu Leu His Leu Ala Lys Arg Arg Gly 100 105 110 Phe Leu Ser Asn Arg Thr Thr Asp Arg Ser Gly Gly Asn Glu Leu Lys 115 120 125 Gly Ile Leu Ala Glu Met Thr Gin Leu Gin Gly Glu Ile Ala Ala His 130 135 140 Gly Cys Gin Thr Leu Gly Gin Tyr Leu His Gin Leu Gly Asp Asp Gly 145 150 155 160 Glu Thr Phe Ala Gin Arg Leu Arg Gly Arg His Thr Leu Arg Ala Met 165 170 175 Tyr Glu Asp Glu Phe Glu Lys Ile Trp Glu Arg Gin Ala Ser Tyr Tyr 180 185 190 Pro Ala Leu Leu Thr Glu Glu Leu Arg Gly Gly Glu Glu Gly Lys Gin 195 200 205 Ser Tyr Pro Leu Val Pro Thr Ala Arg Arg Lys Ser Glu Ser Leu Leu 210 215 220 Lys Arg Phe Gly Leu His Gly Leu Leu Phe Phe Gin Arg Lys Met Tyr 225 230 235 240 Trp Pro Lys Ser Val Ile Gly Arg Cys Asp Leu Glu Pro Lys Glu Lys 245 250 255 Arg Cys Pro Lys Ala Asp Arg Leu Ala Gin Arg Phe Arg Ile Leu Gin 260 265 270 Glu Val Asn Asn Leu Arg Leu Ile Ser Pro Ala Asp Arg Lys Glu Tyr 275 280 285 Thr Phe Ala Glu Phe Val Gly Ala Gly Ala Asp Lys Lys Leu Val Asp 290 295 300 Tyr Leu Cys Glu Ala Lys Glu Arg Thr Phe Pro Gin Ile Arg Lys Lys 305 310 315 320 Phe Lys Leu Pro Glu Thr Ile Ser Phe Asn Tyr Glu Arg Gly Glu Arg 325 330 335 Ser Lys Leu Gin Gly His Glu Thr Asp Ala His Phe Asn Gly Lys Lys Page 142 of 3790 Ala Asn Lys Val Ile Ala His Arg Ser Ala Asn Asn Glu Lys Gly Asp 595 600 605 Arg Thr Pro Trp Glu Trp Leu Gly His Asp Lys Pro Arg Phe Asp Glu 610 615 620 Leu Leu Leu Arg Ala Gin Arg Leu Pro Tyr Gly Lys Arg Gin Arg Phe 625 630 635 640 Ile Gin Lys Glu Val Glu Leu Thr Asn Phe Val Glu Arg Gin Leu Arg 645 650 655 Asp Thr Thr Tyr Val Ser Arg Leu Val Val Gin Tyr Leu Lys Gly Leu 660 665 670 Gly Val Pro Ile Thr Thr Val Lys Gly Pro Met Thr Ala Glu Leu Arg 675 680 685 His His Trp Gly Leu Asn Ala Leu Leu Asn Glu Asp Gly Ser Gin Lys 690 695 700 Lys Asn Arg Ser Asp His Arg His His Ala Ile Asp Ala Ile Val Ile 705 710 715 720 Gly Leu Thr Asp Ala Lys Arg Leu His Ala Leu Ala Asn Ala Arg Gly 725 730 735 Lys Asp Leu Gin Pro Pro Trp Ser Glu Phe Arg Ser Asp Val Ala Thr 740 745 750 Ala Leu Gly Arg Met Ala Val Ser His Arg Val Arg Arg Arg Ile Gin 755 760 765 Gly Ala Leu His Glu Glu Thr Ile Tyr Gly Pro Thr Gin Lys Ala Ala 770 775 780 Gin Pro Thr Ser Thr Asp Gin Arg Pro Trp Ala Lys Asp Trp Ile Glu 785 790 795 800 Asp Ser Gin Ile Val Val Arg Arg Lys Ser Val Ser Asp Leu Thr Asn 805 810 815 Thr Lys His Leu Ala Lys Ile Arg Asp Val Thr Ile Arg Lys Ile Leu 820 825 830 Glu Asp His Leu Arg Arg Gin Lys Val Asp Pro Thr Lys Pro Gly Val 835 840 845 Page 143 of 3790 Phe Asp Ala Arg Lys Val Thr Val Thr Pro Leu Gly Lys Ile Arg 1010 1015 1020 Asn Ala Asn Asp 1025 29 158 PRT Francisella tularensis 29 Page 144 of 3790 Page 145 of 3790 Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 100 105 110 Thr Glu Tyr Leu Asn Ile Val Pro Glu Gin Val Lys Ala Ile Leu Met 115 120 125 Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 130 135 140 Lys Leu Ala Thr Glu Gin Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 145 150 155 160 Leu Met Gin Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 165 170 175 Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 180 185 190 Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 195 200 205 Leu Lys Thr Gin Lys Phe Ser Tyr Thr Asp Lys Gin Gly Asn Leu Lys 210 215 220 Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gin Glu Phe Leu 225 230 235 240 Lys Arg His Ala Thr Ile Asn Asp Glu Ile Leu Asp Thr Leu Leu Thr 245 250 255 Asp Asp Phe Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 260 265 270 Lys Asn Glu Glu Lys Leu Gin Ser Gin Glu Asp Lys Asp His Thr Gin 275 280 285 Ala Tyr Phe His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 290 295 300 Met Ala Ser Gly Gly Arg His Arg Ser Gin Tyr Phe Gin Glu Ile Thr 305 310 315 320 Asn Val Leu Asp Glu Asn Asn His Gin Glu Gly Tyr Leu Lys Asn Phe 325 330 335 Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 340 345 350 Page 146 of 3790 Page 147 of 3790 His Ala Phe Gly Asp Met Ile Ala Asn Asp Pro Lys Phe Ala Asn Arg 180 185 190 Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 195 200 205 Leu Glu Asp Glu Val Arg Ala Ile Leu Arg Ala Gin Leu Arg Phe Gly 210 215 220 Ser Ala Ala Ala Thr Glu Thr Leu Ala Gin Thr Phe Ala Asp Val Ala 225 230 235 240 Phe Phe Gin Arg Pro Leu Gin Asp Ser Glu Asp Arg Val Gly Asp Cys 245 250 255 Pro Phe Glu Pro Gly Gin Lys Arg Ala Ala Arg Arg Ala Pro Ser Phe 260 265 270 Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Ala Val 275 280 285 Gly Arg Ser Pro Glu Arg Arg Leu Thr Ala Glu Glu Ile Ala Leu Ala 290 295 300 Ala Lys Gly Phe Gly Glu Thr Lys Lys Thr Ile Thr Phe Lys Ser Leu 305 310 315 320 Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Ile Gly 325 330 335 Lys Asp Lys Glu Ala Ser Leu Asp Val Val Ala Arg Thr Gly Gly Ala 340 345 350 Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 355 360 365 Arg Ser Leu Ser Arg Thr Pro Glu Thr Leu Asp Arg Ile Ala Glu Ile 370 375 380 Leu Ser Phe Arg Glu Asp Ile Thr Ser Ile Arg Asn Gly Leu Glu Asp 385 390 395 400 Leu Gly Leu Asp Ser Leu Val Val Glu Ala Leu Met Gin Ala Ala Ala 405 410 415 Asn Gly Asp Phe Lys Glu Phe Thr Arg Ala Gly His Ile Ser Ala Arg Page 150 of 3790 32 1149 PRT Lactobacillus salivarius 32 Met Glu Arg Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser Ile Gly 15 10 15 Trp Ala Val Ile Gly Asp Asp Phe Lys Ile Lys Arg Lys Lys Gly Lys 20 25 30 Asn Leu Ile Gly Val Arg Leu Phe Lys Glu Gly Asp Thr Ala Ala Glu 35 40 45 Arg Arg Gly Phe Arg Thr Gin Arg Arg Arg Leu Asn Arg Arg Lys Trp 50 55 60 Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Met Ala Glu Val 65 70 75 80 Page 151 of 3790 Asp Lys Tyr Phe Phe Ala Arg Leu Lys Glu Ser Asn Leu Ser Pro Lys 85 90 95 Asp Ser Asn Lys Lys Tyr Leu Gly Ser Leu Leu Phe Pro Asp Ile Ser 100 105 110 Asp Ser Asn Phe Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Arg 115 120 125 Asp Leu Met Glu Lys Asp Lys Lys Phe Asp Leu Arg Glu Ile Tyr Leu 130 135 140 Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Glu Lys Val 145 150 155 160 Pro Ala Lys Asn Tyr Lys Asn Ser Gly Ala Ser Ile Gly Phe Leu Leu 165 170 175 Glu Glu Val Asn Asp Leu Tyr Gly Asn Ile Ile Gly Asn Glu Asp Val 180 185 190 Ala Ile Leu Asp Asn Asp Lys Phe Glu Asp Val Glu Lys Ile Ile Leu 195 200 205 Asn Asp Glu Ile Arg Asn Ile Asp Lys Gin Lys Asn Val Gly Arg Leu 210 215 220 Leu Val Lys Asp Lys Lys Glu Lys Asn Ile Val Thr Ala Phe Ser Lys 225 230 235 240 Ala Ile Phe Gly Tyr Lys Phe Asn Leu Glu Asp Leu Leu Leu Ile Glu 245 250 255 Ser Asp Glu Lys Asn Lys Leu Thr Phe Asn Asp Glu Asn Ile Asp Asp 260 265 270 Ile Phe Asn Glu Leu Ser His Ser Leu Asn Asp Asn Gin Met Asp Leu 275 280 285 Leu Thr Lys Thr Arg Glu Ile Tyr Phe Lys Phe Lys Leu Asn Met Ile 290 295 300 Val Pro Thr Gly Tyr Thr Ile Ser Glu Ser Met Ile Glu Lys Tyr Glu 305 310 315 320 Met His Lys Ala His Leu Lys Met Tyr Lys Glu Phe Ile Asn Thr Leu 325 330 335 Page 152 of 3790 Asn Ala Lys Asp Arg Lys Ile Leu Lys Asn Ala Tyr Ser Asp Tyr Ile 340 345 350 Asn Asn Glu Lys Ala Lys Ala Ala Asn Ala Gin Glu Asn Phe Tyr Lys 355 360 365 Thr Val Lys Lys Thr Ile Lys Glu Asn Asp Ser Asp Thr Ala Lys Lys 370 375 380 Ile Ile Gly Leu Ile Asp Glu Gly Asn Phe Met Pro Lys Gin Arg Thr 385 390 395 400 Gly Glu Asn Gly Val Ile Pro His Gin Leu His Gin Ile Glu Leu Asp 405 410 415 Arg Ile Ile Glu Asn Gin Ala Lys Tyr Tyr Pro Trp Leu Ala Glu Glu 420 425 430 Asn Pro Val Glu Lys Asn Arg Lys Phe Ala Lys Tyr Lys Leu Asp Glu 435 440 445 Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Asp Lys 450 455 460 Thr Glu Ser Asn Lys Asn Glu Lys Glu Thr Lys Phe Ala Trp Met Val 465 470 475 480 Arg Lys Ala Lys Gly Thr Ile Thr Pro Trp Asn Phe Glu Asn Leu Val 485 490 495 Asp Arg Thr Glu Ser Ala Asn Arg Phe Ile Lys Arg Met Thr Ser Lys 500 505 510 Asp Thr Tyr Ile Ile Gly Glu Asp Val Leu Pro Ala Ser Ser Leu Leu 515 520 525 Tyr Glu Lys Tyr Lys Val Leu Asn Glu Leu Asn Asn Ile Lys Val Asn 530 535 540 Lys Lys Lys Leu Asp Val Glu Gin Lys Gin His Val Tyr Leu Asp Leu 545 550 555 560 Phe Thr Thr Arg Lys Asn Val Thr Lys Asp Asp Leu Ala Thr Ser Leu 565 570 575 Asn Cys Asp Val Glu Ser Ile Thr Gly Leu Thr Asp Asn Lys Lys Phe Page 154 of 3790 Asn Gly Ala Phe Tyr Asp Gin Thr Lys Tyr Asn Ala Lys Thr Ile 1070 1075 1080 Page 155 of 3790 1145 33 1064 PRT Rhodopseudomonas palustris 33 Met Ser Glu Cys Val Thr Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 15 10 15 Ala Ser Cys Gly Trp Gly Val 20 Ile Glu Val 25 Gly Glu Ala Ser Gly 30 Ser Ile Ile Ala 35 Ser Gly Val Arg Cys 40 Phe Asp Ala Pro Leu Ile Asp Lys Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gin Arg 50 55 60 Arg Ile 65 Ile Arg Arg Arg 70 Arg Gin Arg Met Asn Ala Val 75 Arg Arg Leu 80 Leu Ala Glu Phe Gly Val 85 Leu Thr Gly Arg 90 Ser Pro Asp Ala Leu 95 His Gin Ala Leu Leu Arg Leu 100 Ser Gin Ser Val Ala Gly 105 Ser Gin Val 110 Thr Pro Trp Thr 115 Leu Arg Ala Ala Ala 120 His Glu Arg Lys Leu Thr Asn Asp 125 Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 130 135 140 Page 156 of 3790 Ser Asn Ser Lys Asn Asp Gly Gly Ala Asn Ala Ala Asp Glu Thr Ser 145 150 155 160 Lys Met Lys Lys Ala Met Glu Thr Thr Arg Glu Gly Leu Ala Arg Tyr 165 170 175 His Ser Phe Gly Ala Met Ile Ala Ser Asp Pro Lys Phe Ala Asp Arg 180 185 190 Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 195 200 205 Leu Glu Asp Glu Val Arg Thr Ile Phe Arg Ser Gin Thr Arg Phe Gly 210 215 220 Ser Leu Val Ala Ser Glu Lys Leu Ser Gin Ala Phe Ala Asp Ala Ala 225 230 235 240 Phe Phe Gin Arg Pro Leu Gin Asp Ser Glu Asp Met Val Gly Ser Cys 245 250 255 Pro Phe Glu Pro Gly Gin Lys Arg Thr Ala Arg Arg Ala Pro Ser Phe 260 265 270 Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Thr Val 275 280 285 Gly Arg Ala Pro Glu Arg Arg Leu Thr Pro Asp Glu Ile Ala Leu Ala 290 295 300 Ala Lys Gly Phe Gly Glu Thr Lys Lys Ser Ile Thr Phe Lys Ser Leu 305 310 315 320 Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Val Ala 325 330 335 Lys Glu Lys Glu Ser Thr Leu Asp Val Ala Ala Arg Thr Gly Gly Ala 340 345 350 Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 355 360 365 Arg Ser Leu Ser Arg Met Pro Glu Lys Leu Asp Arg Ile Ala Glu Ile 370 375 380 Leu Ser Phe Arg Glu Asp Met Lys Ala Ile Arg Asn Gly Leu Glu Glu 385 390 395 400 Page 157 of 3790 Val Gly Leu Asp Gly Leu Val Val Asp Ala Leu Met Gin Ala Thr Ala 405 410 415 Asn Gly Asp Phe Lys Asp Phe Thr Arg Ala Ala His Ile Ser Ala Leu 420 425 430 Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 435 440 445 Asp Ala Cys Thr Arg Val Gly Tyr Asp His Ala Ala Arg Pro Ala Val 450 455 460 Pro Leu Ser Gin Ile Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 465 470 475 480 Ala Leu Lys Gin Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 485 490 495 Tyr Phe His Ile Glu Leu Ala Arg Ser Ile Gly Lys Ser Ala Glu Glu 500 505 510 Arg Lys Lys Leu Thr Asp Gly Ile Glu Ala Arg Asn Val Glu Lys Glu 515 520 525 Lys Arg Arg Lys Glu Ala Ala Glu His Leu Gly Arg Ala Pro Ser Asp 530 535 540 Asp Glu Leu Leu Arg Tyr Glu Leu Ala Lys Glu Gin Asn Phe Lys Cys 545 550 555 560 Ile Tyr Ser Gly Asp Pro Ile Asp Pro Ala Gly Ile Ser Ala Asn Asp 565 570 575 Thr Arg Tyr Gin Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 580 585 590 Asp Ser Tyr Val Asn Lys Thr Leu Cys Thr Ala Arg Ser Asn Gin Asn 595 600 605 Lys Arg Gly Arg Thr Pro Phe Glu Trp Phe Asp Ala Asp Lys Thr Glu 610 615 620 Ala Glu Trp Met Glu Tyr Ser Ala Arg Val Glu Asp Leu Lys Glu Val 625 630 635 640 Lys Gly Arg Lys Lys Arg Asn Tyr Ser Ile Lys Asp Ala Ala Ser Val Page 161 of 3790 Glu His Ile Ile Phe Tyr Gin Arg Pro Leu Lys Pro Ala Ile Val Gly 305 310 315 320 Lys Cys Thr Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu 325 330 335 Gly Tyr Arg Ala Pro Trp Ser His Pro Leu Ala Gin Arg Phe Arg Ile 340 345 350 Leu Ser Glu Ala Arg Asn Leu Glu Ile Arg Asp Thr Gly Lys Gly Ser 355 360 365 Arg Arg Leu Thr Lys Glu Gin Ser Asp Leu Val Val Ala Ala Leu Leu 370 375 380 Ala Asn Arg Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu 385 390 395 400 Pro Ala Glu Ala Arg Phe Asn Leu Glu Ser Asp Arg Arg Ala Ala Leu 405 410 415 Asp Gly Asp Gin Thr Ala Ala Arg Leu Ser Asp Lys Lys Gly Phe Asn 420 425 430 Lys Ala Trp Arg Gly Phe Pro Pro Glu Arg Gin Ile Ala Ile Val Ala 435 440 445 Arg Leu Glu Glu Thr Glu Asp Glu Asn Glu Leu Ile Ala Trp Leu Glu 450 455 460 Lys Glu Cys Ala Leu Asp Gly Ala Ala Ala Ala Arg Val Ala Asn Thr 465 470 475 480 Thr Leu Pro Asp Gly His Cys Arg Leu Gly Leu Arg Ala Ile Lys Lys 485 490 495 Ile Val Pro Ile Met Gin Asp Gly Leu Asp Glu Asp Gly Val Ala Gly 500 505 510 Ala Gly Tyr His Ile Ala Ala Lys Arg Ala Gly Tyr Asp His Ala Lys 515 520 525 Leu Pro Thr Gly Glu Gin Leu Gly Arg Leu Pro Tyr Tyr Gly Gin Trp 530 535 540 Leu Gin Asp Ala Val Val Gly Ser Gly Asp Ala Arg Asp Gin Lys Glu 545 550 555 560 Page 162 of 3790 Lys Gin Tyr Gly Gin Phe Pro Asn Pro Thr Val His Ile Gly Leu Gly 565 570 575 Gin Leu Arg Arg Val Val Asn Asp Leu Ile Asp Lys Tyr Gly Pro Pro 580 585 590 Thr Glu Ile Ser Ile Glu Phe Thr Arg Ala Leu Lys Leu Ser Glu Gin 595 600 605 Gin Lys Ala Glu Arg Gin Arg Glu Gin Arg Arg Asn Gin Asp Lys Asn 610 615 620 Lys Ala Arg Ala Glu Glu Leu Ala Lys Phe Gly Arg Pro Ala Asn Pro 625 630 635 640 Arg Asn Leu Leu Lys Met Arg Leu Trp Glu Glu Leu Ala His Asp Pro 645 650 655 Leu Asp Arg Lys Cys Val Tyr Thr Gly Glu Gin Ile Ser Ile Glu Arg 660 665 670 Leu Leu Ser Asp Glu Val Asp Ile Asp His Ile Leu Pro Val Ala Met 675 680 685 Thr Leu Asp Asp Ser Pro Ala Asn Lys Ile Ile Cys Met Arg Tyr Ala 690 695 700 Asn Arg His Lys Arg Lys Gin Thr Pro Ser Glu Ala Phe Gly Ser Ser 705 710 715 720 Pro Thr Leu Gin Gly His Arg Tyr Asn Trp Asp Asp Ile Ala Ala Arg 725 730 735 Ala Thr Gly Leu Pro Arg Asn Lys Arg Trp Arg Phe Asp Ala Asn Ala 740 745 750 Arg Glu Glu Phe Asp Lys Arg Gly Gly Phe Leu Ala Arg Gin Leu Asn 755 760 765 Glu Thr Gly Trp Leu Ala Arg Leu Ala Lys Gin Tyr Leu Gly Ala Val 770 775 780 Thr Asp Pro Asn Gin Ile Trp Val Val Pro Gly Arg Leu Thr Ser Met 785 790 795 800 Leu Arg Gly Lys Trp Gly Leu Asn Gly Leu Leu Pro Ser Asp Asn Tyr 805 815 Page 163 of 3790 810 35 641 PRT Nitrobacter hamburgensis 35 Page 165 of 3790 Gly Arg Ala Ile Phe His Leu Asn Gin Arg Arg Gly Phe Gin Ser Asn 100 105 110 Arg Lys Thr Asp Arg Lys Gin Ser Glu Asp Gly Ala Ile Lys Gin Ala 115 120 125 Ala Ser Lys Leu Lys Ala Arg Met His Glu Glu Ala Ala Pro Thr Leu 130 135 140 Gly Ala Phe Phe Ala Asp Met His Leu Arg Lys Ser Tyr Asp Asp Gin 145 150 155 160 Gin Thr Ala Ile Arg Ala Glu Leu Val Arg Leu Gly Lys Asp His Leu 165 170 175 Thr Gly Asn Ala Arg Lys Lys Val Trp Ala Lys Val Arg Lys Arg Leu 180 185 190 Phe Gly Asp Glu Val Leu Arg Pro Lys Asp Thr Ser Asp Gly Ala Arg 195 200 205 Ala Arg Ala Thr Thr Thr Gly Thr Lys Ala Ser Tyr Asp Phe Tyr Pro 210 215 220 Thr Arg Ala Met Leu Leu Asp Glu Phe Asn Ala Ile Trp Ala Ala Gin 225 230 235 240 Arg Glu His His Leu Ala Met Thr Asp Glu Ala Lys Ala Glu Ile Glu 245 250 255 His Ile Ile Phe Tyr His Arg Pro Leu Lys Pro Ala Ile Val Gly Lys 260 265 270 Cys Thr Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu Gly 275 280 285 Tyr Arg Ala Pro Trp Ser His Pro Leu Ala Gin Arg Phe Arg Ile Leu 290 295 300 Ser Glu Ala Arg Asn Leu Glu Ile Arg Glu Thr Gly Lys Thr Ser Arg 305 310 315 320 Arg Leu Thr Lys Asp Gin Ser Asp Leu Val Val Ala Ala Leu Leu Ala 325 330 335 Asn Arg Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu Pro 340 345 350 Page 166 of 3790 Ala Glu Ala Arg Phe Asn Leu Glu Ser Asp Arg Arg Ser Thr Ala Thr 355 360 365 Arg Pro Pro His Gly Cys Arg Thr Arg Arg Ala Ser Ile Arg Arg Gly 370 375 380 Ala Gly Phe Leu Arg Asn Gly Arg Ser Arg Ser Ser Pro Asp Trp Lys 385 390 395 400 Lys Pro Lys Thr Lys Thr Asn Cys Ser His Gly Ser Lys Trp Asn Ala 405 410 415 His Leu Thr Ala Gin Arg Pro Arg Ala Ser Pro Ile Arg Arg Cys Arg 420 425 430 Thr Ala Ile Ala Gly Ser Ala Cys Ala Gin Ser Lys Arg Ser Cys Arg 435 440 445 Ser Cys Arg Thr Ser Ser Met Arg Met Ala Leu Arg Ala Pro Ala Ile 450 455 460 Thr Ser Trp Pro Ser Val Pro Ala Thr Thr Ile Pro Val Asp Thr Phe 465 470 475 480 Gin Gin Gly Gly Asn Ala Phe Gly Arg Ile Leu Ser Val Val Thr Ile 485 490 495 Glu Leu Phe Ala Ile Thr Asp Arg Val Asp Pro Val Gin Glu Gin Asp 500 505 510 Ala Arg Cys Phe Ala Leu Arg Ile Ala Glu Cys Arg Ser Asp Gly Leu 515 520 525 Gin His Phe Ala Glu Val Ser Leu Gly Leu Pro Pro Arg Asn Ala Ala 530 535 540 Gin Asp Gin Arg His Ser Ala Gly Leu Cys Gin Ser Ser Cys Val Gly 545 550 555 560 Arg Phe Val Pro Gly Thr Pro Cys Arg Arg Thr Pro Arg Ser Thr Ser 565 570 575 Leu His Gly Lys Glu Pro Ser Ala His Ala Phe Gly Ser Thr Ala Arg 580 585 590 Ser Arg Pro Gin Leu Pro Ala Ser Pro Arg Pro Cys Met Ser Phe Arg 595 600 605 Page 167 of 3790 Asp Gly Thr Ser Ser Ser Pro Ala Arg Met Pro Glu Thr Leu Asp Arg 610 615 620 Cys Ala Ile Ser Arg Ser Asn Arg Ser Ser Val Cys Arg Ala Glu Arg 625 630 635 640 Leu 36 1368 PRT Streptococcus pyogenes 36 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Page 168 of 3790 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe Page 171 of 3790 Page 172 of 3790 37 1368 PRT Streptococcus pyogenes 37 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 173 of 3790 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp Page 175 of 3790 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 176 of 3790 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Page 177 of 3790 Pro Glu Asp Asn Glu Gin Lys Gin Leu Phe Val Glu Gin His Lys 38 1368 PRT Streptococcus pyogenes 38 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Ile Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys Page 180 of 3790 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Page 181 of 3790 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Ile Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Page 182 of 3790 Glu Val Gin Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 39 Page 185 of 3790 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Page 186 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg His Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Ile Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Page 187 of 3790 Lys Glu Ala Ile Gin Lys Ala Gin Val Ser Gly Gin Gly His Ser Leu 705 710 715 720 His Glu Gin Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr 755 760 765 Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 770 775 780 Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro Val 785 790 795 800 Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gin 805 810 815 Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg Leu 820 825 830 Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Ile Lys Asp 835 840 845 Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 850 855 860 Lys Ser Asp Asp Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 865 870 875 880 Tyr Trp Arg Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys Phe 885 890 895 Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 900 905 910 Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys 915 920 925 His Val Ala Gin Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 930 935 940 Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 960 945 950 Page 188 of 3790 955 Page 189 of 3790 40 1121 PRT Streptococcus thermophilus 40 Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 15 10 15 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270 Page 191 of 3790 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gin Lys Asn Gin Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 325 330 335 Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 340 345 350 Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gin Met Asp 355 360 365 Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Gin Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 385 390 395 400 Phe Ser Gin Lys Gin Val Asp Glu Leu Val Gin Phe Arg Lys Ala Asn 405 410 415 Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 420 425 430 Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr 435 440 445 Ile Leu Thr Arg Leu Gly Lys Gin Lys Thr Thr Ser Ser Ser Asn Lys 450 455 460 Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Val Asn Ala Ala 485 490 495 Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 500 505 510 Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Lys Ile Gin Lys 515 520 525 Page 192 of 3790 Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gin 530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 545 550 555 560 Gin Leu Ala Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 580 585 590 Asn Gin Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu Asp Ser Met Asp Asp Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 645 650 655 Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 660 665 670 Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gin Glu His Phe Arg Ala 690 695 700 His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Asn 740 745 750 Leu Trp Lys Lys Gin Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gin 755 760 765 Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys Gly Thr Gly Thr 995 Tyr Lys Ile Ser Gin Glu Lys Tyr Asn Asp Ile Lys 1000 1005 Lys Lys 1010 Glu Gly Val Asp Ser Asp Ser Glu Phe Lys 1015 1020 Phe Thr Leu 41 1388 PRT Streptococcus thermophilus 41 Page 195 of 3790 Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Ala Tyr 115 120 125 His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 130 135 140 Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 165 170 175 Lys Asn Asn Asp Ile Gin Lys Asn Phe Gin Asp Phe Leu Asp Thr Tyr 180 185 190 Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gin Leu 195 200 205 Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 210 215 220 Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Arg Lys Cys Phe 245 250 255 Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 260 265 270 Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 275 280 285 Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 305 310 315 320 Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 325 330 335 Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 340 345 350 Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 196 of 3790 Gin Glu Asp Phe Tyr Val Tyr Leu Lys Lys Leu Leu Ala Glu Phe Glu 370 375 380 Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Leu Asp Lys Gin Ala Lys Phe Tyr Pro Phe 420 425 430 Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 450 455 460 Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 465 470 475 480 Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 515 520 525 Phe Ile Ala Glu Ser Met Arg Asp Tyr Gin Phe Leu Asp Ser Lys Gin 530 535 540 Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 545 550 555 560 Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 565 570 575 Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ser Ser Leu Ser Thr 580 585 590 Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 595 600 605 Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 610 615 620 Page 197 of 3790 Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ser Lys Phe Glu Asn 625 630 635 640 Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 645 650 655 Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 660 665 670 Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 675 680 685 Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ala Leu Ser Phe Lys 690 695 700 Lys Lys Ile Gin Lys Ala Gin Ile Ile Gly Asp Glu Asp Lys Gly Asn 705 710 715 720 Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 740 745 750 Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Tyr Thr Asn Gin Gly Lys Ser Asn Ser Gin Gin Arg Leu Lys Arg 770 775 780 Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 785 790 795 800 Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gin Asn Asp 805 810 815 Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly 820 825 830 Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 835 840 845 Ile Pro Gin Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 850 855 860 Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Leu 880 865 870 Page 198 of 3790 875 Glu Glu Gin Asn His Gly Leu Asp Arg Gly Lys Pro Lys Gly Leu 1100 1105 1110 Page 199 of 3790 Page 200 of 3790 42 1138 PRT Acidothermus cellulolyticus 42 Page 201 of 3790 Glu Pro Gly Thr Val Gly Gin Trp Ala Gly Tyr Leu Leu Gin Arg Ala 180 185 190 Pro Gly Ile Arg Leu Asn Pro Thr Gin Gin Ser Ala Gly Arg Arg Ala 195 200 205 Glu Leu Ser Asn Ala Thr Ala Phe Glu Thr Arg Leu Arg Gin Glu Asp 210 215 220 Val Leu Trp Glu Leu Arg Cys Ile Ala Asp Val Gin Gly Leu Pro Glu 225 230 235 240 Asp Val Val Ser Asn Val Ile Asp Ala Val Phe Cys Gin Lys Arg Pro 245 250 255 Ser Val Pro Ala Glu Arg Ile Gly Arg Asp Pro Leu Asp Pro Ser Gin 260 265 270 Leu Arg Ala Ser Arg Ala Cys Leu Glu Phe Gin Glu Tyr Arg Ile Val 275 280 285 Ala Ala Val Ala Asn Leu Arg Ile Arg Asp Gly Ser Gly Ser Arg Pro 290 295 300 Leu Ser Leu Glu Glu Arg Asn Ala Val Ile Glu Ala Leu Leu Ala Gin 305 310 315 320 Thr Glu Arg Ser Leu Thr Trp Ser Asp Ile Ala Leu Glu Ile Leu Lys 325 330 335 Leu Pro Asn Glu Ser Asp Leu Thr Ser Val Pro Glu Glu Asp Gly Pro 340 345 350 Ser Ser Leu Ala Tyr Ser Gin Phe Ala Pro Phe Asp Glu Thr Ser Ala 355 360 365 Arg Ile Ala Glu Phe Ile Ala Lys Asn Arg Arg Lys Ile Pro Thr Phe 370 375 380 Ala Gin Trp Trp Gin Glu Gin Asp Arg Thr Ser Arg Ser Asp Leu Val 385 390 395 400 Ala Ala Leu Ala Asp Asn Ser Ile Ala Gly Glu Glu Glu Gin Glu Leu 405 410 415 Leu Val His Leu Pro Asp Ala Glu Leu Glu Ala Leu Glu Gly Leu Ala 420 425 430 Page 202 of 3790 Leu Pro Ser Gly Arg Val Ala Tyr Ser Arg Leu Thr Leu Ser Gly Leu 435 440 445 Thr Arg Val Met Arg Asp Asp Gly Val Asp Val His Asn Ala Arg Lys 450 455 460 Thr Cys Phe Gly Val Asp Asp Asn Trp Arg Pro Pro Leu Pro Ala Leu 465 470 475 480 His Glu Ala Thr Gly His Pro Val Val Asp Arg Asn Leu Ala Ile Leu 485 490 495 Arg Lys Phe Leu Ser Ser Ala Thr Met Arg Trp Gly Pro Pro Gin Ser 500 505 510 Ile Val Val Glu Leu Ala Arg Gly Ala Ser Glu Ser Arg Glu Arg Gin 515 520 525 Ala Glu Glu Glu Ala Ala Arg Arg Ala His Arg Lys Ala Asn Asp Arg 530 535 540 Ile Arg Ala Glu Leu Arg Ala Ser Gly Leu Ser Asp Pro Ser Pro Ala 545 550 555 560 Asp Leu Val Arg Ala Arg Leu Leu Glu Leu Tyr Asp Cys His Cys Met 565 570 575 Tyr Cys Gly Ala Pro Ile Ser Trp Glu Asn Ser Glu Leu Asp His Ile 580 585 590 Val Pro Arg Thr Asp Gly Gly Ser Asn Arg His Glu Asn Leu Ala Ile 595 600 605 Thr Cys Gly Ala Cys Asn Lys Glu Lys Gly Arg Arg Pro Phe Ala Ser 610 615 620 Trp Ala Glu Thr 625 Ser Asn Arg 630 Val Gin Leu Arg Asp Val 635 Ile Asp Arg 640 Val Gin Lys Leu Lys 645 Tyr Ser Gly Asn Met 650 Tyr Trp Thr Arg Asp Glu 655 Phe Ser Arg Tyr Lys Lys 660 Ser Val Val 665 Ala Arg Leu Lys Arg Arg 670 Thr Ser Asp Pro Glu Val Ile Gin Ser Ile Glu Ser Thr Gly Tyr Ala Ala Page 203 of 3790 675 680 685 Val Ala Leu Arg Asp Arg Leu Leu Ser Tyr Gly Glu Lys Asn Gly Val 690 695 700 Ala Gin Val Ala Val Phe Arg Gly Gly Val Thr Ala Glu Ala Arg Arg 705 710 715 720 Trp Leu Asp Ile Ser Ile Glu Arg Leu Phe Ser Arg Val Ala Ile Phe 725 730 735 Ala Gin Ser Thr Ser Thr Lys Arg Leu Asp Arg Arg His His Ala Val 740 745 750 Asp Ala Val Val Leu Thr Thr Leu Thr Pro Gly Val Ala Lys Thr Leu 755 760 765 Ala Asp Ala Arg Ser Arg Arg Val Ser Ala Glu Phe Trp Arg Arg Pro 770 775 780 Ser Asp Val Asn Arg His Ser Thr Glu Glu Pro Gin Ser Pro Ala Tyr 785 790 795 800 Arg Gin Trp Lys Glu Ser Cys Ser Gly Leu Gly Asp Leu Leu Ile Ser 805 810 815 Thr Ala Ala Arg Asp Ser Ile Ala Val Ala Ala Pro Leu Arg Leu Arg 820 825 830 Pro Thr Gly Ala Leu His Glu Glu Thr Leu Arg Ala Phe Ser Glu His 835 840 845 Thr Val Gly Ala Ala Trp Lys Gly Ala Glu Leu Arg Arg Ile Val Glu 850 855 860 Pro Glu Val Tyr Ala Ala Phe Leu Ala Leu Thr Asp Pro Gly Gly Arg 865 870 875 880 Phe Leu Lys Val Ser Pro Ser Glu Asp Val Leu Pro Ala Asp Glu Asn 885 890 895 Arg His Ile Val Leu Ser Asp Arg Val Leu Gly Pro Arg Asp Arg Val 900 905 910 Lys Leu Phe Pro Asp Asp Arg Gly Ser Ile Arg Val Arg Gly Gly Ala 915 920 925 Page 204 of 3790 995 1000 1005 43 1629 PRT Francisella novicida 43 Page 205 of 3790 Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 15 10 15 Thr Gly Val Phe Ser Ala Phe Tyr Gin Lys Gly Thr Ser Leu Glu Arg 20 25 30 Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 35 40 45 Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gin Arg Arg Gly 50 55 60 Ile Asp Arg Lys Gin Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 65 70 75 80 Glu Gin Leu Asn Leu Glu Trp Asp Lys Asp Thr Gin Gin Ala Ile Ser 85 90 95 Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 100 105 110 Pro Glu Tyr Leu Asn Ile Val Pro Glu Gin Val Lys Ala Ile Leu Met 115 120 125 Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 130 135 140 Lys Leu Ala Thr Glu Gin Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 145 150 155 160 Leu Met Gin Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 165 170 175 Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 180 185 190 Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 195 200 205 Leu Lys Thr Gin Lys Phe Ser Tyr Thr Asp Lys Gin Gly Asn Leu Lys 210 215 220 Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gin Glu Phe Leu 225 230 235 240 Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 245 250 255 Page 206 of 3790 Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 260 265 270 Lys Asn Glu Glu Lys Leu Gin Asn Gin Glu Asp Lys Asp His Ile Gin 275 280 285 Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 290 295 300 Met Ala Ser Gly Gly Arg His Arg Ser Gin Tyr Phe Gin Glu Ile Thr 305 310 315 320 Asn Val Leu Asp Glu Asn Asn His Gin Glu Gly Tyr Leu Lys Asn Phe 325 330 335 Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 340 345 350 Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 355 360 365 Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 370 375 380 Glu Gin Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 385 390 395 400 Arg Val Gly Val Lys Asp Gin Asp Lys Lys Asp Gly Ala Lys Tyr Ser 405 410 415 Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gin Lys Val Thr Lys Ala Gly 420 425 430 Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 435 440 445 Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gin Ser Leu Ile 450 455 460 Leu Asn Pro Lys Phe Leu Asp Asn Gin Tyr Pro Asn Trp Gin Gin Tyr 465 470 475 480 Leu Gin Glu Leu Lys Lys Leu Gin Ser Ile Gin Asn Tyr Leu Asp Ser 485 490 495 Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gin Pro Tyr 500 505 510 Page 207 of 3790 Phe Val Glu Tyr Lys Ser Ser Asn Gin Gin Ile Ala Ser Gly Gin Arg 515 520 525 Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gin Phe Ile Phe Asp Arg 530 535 540 Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gin Ala 545 550 555 560 Lys Lys Leu Lys Gin Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 565 570 575 Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gin Leu Ser Gin Ile 580 585 590 Leu Lys Ser Gin His Thr Asn Gly Ile Phe Glu Gin Gly Thr Phe Leu 595 600 605 His Leu Val Cys Lys Tyr Tyr Lys Gin Arg Gin Arg Ala Arg Asp Ser 610 615 620 Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 625 630 635 640 Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gin Leu Leu Thr Tyr 645 650 655 Cys Asn His Lys Pro Arg Gin Lys Arg Tyr Gin Leu Leu Asn Asp Leu 660 665 670 Ala Gly Val Leu Gin Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 675 680 685 Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 690 695 700 Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gin Lys Asp Asn 705 710 715 720 Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 725 730 735 Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 740 745 750 Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly Page 208 of 3790 Page 210 of 3790 Page 211 of 3790 1625 Ser Leu Gly Trp Ala Ile Phe Arg Leu Asn Glu Ala Arg Glu Pro Thr 20 25 30 Ala Ile Ile Arg Ala Gly Val 35 Arg Ile Phe Ser Asp Gly Arg Asn Ala 45 Asn Ser Glu Pro Leu Ala Val His Arg Arg Val Ala Arg Ala Met Arg 50 55 60 Page 212 of 3790 Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Lys Arg Met His Asp Gin 65 70 75 80 Leu Val Gin His Gly Phe Phe Pro Ala Glu Val Ala Glu Arg Lys Glu 85 90 95 Leu Glu Arg Leu Asn Pro Tyr Gin Leu Arg Ala Lys Gly Leu His Glu 100 105 110 Ala Leu Thr Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gin 115 120 125 Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Lys Asp Asn Asp 130 135 140 Ser Gly Ala Leu Lys Gin Ala Ile Ser Glu Leu Arg Lys Arg Ile Gin 145 150 155 160 Asp Ser Asp Cys Ala Thr Ala Gly Glu Trp Phe Trp Lys Glu Arg Met 165 170 175 Gin Gin Lys Pro Glu Gly Val Arg Gly Gin Trp Val Arg Ala Arg Tyr 180 185 190 Arg Lys Thr Pro Ser Thr Thr Asp Glu Gly Lys Lys Arg Ile Gly Tyr 195 200 205 Asp Leu Tyr Val Asp Arg Ala Met Val Glu Gin Glu Phe Asp Ala Leu 210 215 220 Trp Ala Ala Gin Ala Ala Leu Gin Pro Gly Leu Phe Thr Glu Ala Ala 225 230 235 240 Arg Ala Glu Leu Lys Asp Thr Leu Leu Tyr Gin Arg Asp Leu Arg Pro 245 250 255 Val Lys Pro Gly Arg Cys Thr Leu Leu Pro Ala Glu Glu Arg Ala Pro 260 265 270 Leu Ala Leu Pro Ser Thr Gin Arg Phe Arg Ile Leu Gin Glu Val Asn 275 280 285 Asn Leu Arg Leu 290 Leu Asp Glu Ala 295 Leu Arg Glu Val 300 Pro Leu Asn Leu Ala Gin Arg Asp Ala Val Val Ser Ala Leu Glu Gly Lys Lys Glu Leu Page 214 of 3790 Gin Thr Gin Arg Glu Gin Ala Asp Asn Gin Lys Arg Asn Glu Asp Ile 565 570 575 Arg Lys Arg Ile Ala Pro Ile Leu Glu Thr Ser Pro Glu Arg Val Arg 580 585 590 Asp Arg Asp Ile Lys Lys Trp Ile Leu Trp Glu Glu Leu Asn Lys Lys 595 600 605 Asp Ile Ala Asp Arg His Cys Pro Tyr Ser Gly Glu Arg Ile Ser Ala 610 615 620 Thr Met Leu Leu Ser Glu Ala Val Glu Ile Glu His Ile Leu Pro Phe 625 630 635 640 Ser Arg Thr Leu Asp Asp Ser Leu Asn Asn Arg Thr Val Ala Met Arg 645 650 655 Arg Ala Asn Arg Ile Lys Gly Asp Arg Thr Pro Trp Glu Ala Arg Ala 660 665 670 Asp Phe Glu Ala Gin Gly Trp Arg Tyr Glu Ala Ile Leu Gin Arg Ala 675 680 685 Glu Gly Met Pro Pro Arg Lys Arg Tyr Arg Phe Ala Glu Asp Gly Tyr 690 695 700 Gin Arg Trp Leu Gly Lys Asp Arg Asn Phe Leu Ala Arg Ala Leu Asn 705 710 715 720 Asp Thr Ser Tyr Leu Ser Arg Leu Ala Ala Asn Tyr Leu Arg Leu Val 725 730 735 Cys Pro Gin Gly Val Arg Val Ile Pro Gly Gin Met Thr Asp Lys Leu 740 745 750 Arg Gly Lys Phe Gly Leu Asn Ser Val Leu Gly Leu Asp Gly Lys Lys 755 760 765 Asn Arg Asn Asp His Arg His His Ala Val Asp Ala Cys Val Ile Gly 770 775 780 Val Thr Asp Gin Gly Leu Met Gin Arg Phe Ala Asn Ala Ser Lys Gin 785 790 795 800 Ala Arg Glu Asn Gly Leu Thr Arg Leu Val Gin Asp Met Leu Leu Pro 805 810 815 Page 215 of 3790 Met Glu Val Asp 995 Gly Arg Asp Glu Val Met Arg Val Val Lys Met Ser 1000 1005 Gly Lys 1010 Glu Met Val Phe Ala 1015 Pro Val Arg Glu Ala 1020 Asn Val Asp Lys Arg 1025 Asn Asn Met Pro Asp 1030 Glu Gin Asp Pro Phe 1035 Thr Tyr Thr Tyr Lys 1040 Arg Ala Asp Gin Leu 1045 Arg Lys Ala Lys Ala 1050 Arg Gin Val Thr Ile Ser Pro Ile Gly Glu Leu Arg Asp Pro Gly Phe Lys Gly 1055 1060 1065 Page 216 of 3790 45 1125 PRT Francisella tularensis 45 Met Asn Val Lys Ile Leu Pro Ile Ala Ile Asp Leu Asp Val Lys Asn 15 10 15 Thr Gly Val Phe Ser Ala Phe Tyr Gin Lys Gly Thr Ser Leu Glu Lys 20 25 30 Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 35 40 45 Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gin Arg Arg Gly 50 55 60 Ile Asp Arg Lys Gin Leu Val Lys Arg Leu Phe Lys Leu Val Trp Thr 65 70 75 80 Glu Gin Leu Asn Leu Glu Trp Asp Lys Asp Thr Gin Gin Ala Ile Ser 85 90 95 Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 100 105 110 Thr Glu Tyr Leu Asn Ile Val Pro Glu Gin Val Lys Ala Ile Leu Met 115 120 125 Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 130 135 140 Lys Leu Ala Thr Glu Gin Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 145 150 155 160 Leu Met Gin Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 165 170 175 Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 180 185 190 Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 195 200 205 Leu Lys Ile Gin Lys Phe Ser Tyr Thr Asp Lys Gin Gly Asn Leu Lys 210 215 220 Page 217 of 3790 Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gin Glu Phe Leu 225 230 235 240 Lys Arg His Ala Thr Ile Asn Asp Glu Ile Leu Asp Thr Leu Leu Thr 245 250 255 Asp Asp Phe Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 260 265 270 Lys Asn Glu Glu Lys Leu Gin Asn Gin Glu Asp Lys Asp His Thr Gin 275 280 285 Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 290 295 300 Met Ala Ser Gly Gly Arg His Arg Ser Gin Tyr Phe Gin Glu Ile Thr 305 310 315 320 Asn Val Leu Asp Glu Asn Asn His Gin Glu Gly Tyr Leu Lys Asn Phe 325 330 335 Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 340 345 350 Leu Val Asn Leu Val Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 355 360 365 Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 370 375 380 Glu Gin Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 385 390 395 400 Arg Val Gly Val Lys Asp Gin Asp Lys Lys Asp Gly Ala Lys Tyr Ser 405 410 415 Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gin Lys Val Thr Lys Ala Gly 420 425 430 Leu Ile Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 435 440 445 Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gin Ser Leu Ile 450 455 460 Leu Asn Pro Lys Phe Leu Asp Asn Gin Tyr Pro Asn Trp Gin Gin Tyr Page 219 of 3790 Cys Lys Ala Ala Val Glu Met Gin Lys Gin Tyr Arg Gly Thr Leu Lys 725 730 735 Asn Ala Ile Gin Thr Ala Ile Phe Arg Gin Ser Glu Asn Ile Asn Lys 740 745 750 Asn Lys Asn Lys Asn Thr Gly Asn Gin Gin Gin Ala Leu Ser Glu Asn 755 760 765 Ser Lys Asp Val Lys Ser Leu Thr Ala Asp Glu Lys Lys Leu Leu Lys 770 775 780 Leu Ile Glu Asn Ile Ala Lys Ala Ser Gin Lys Ile Gly Glu Ser Leu 785 790 795 800 Gly Leu Asn Asp Lys Gin Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe 805 810 815 Ala Gin Ile Gin Gin Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn 820 825 830 Thr Cys Ala Val Cys Ser Ala Asp Asn Ala His Arg Met Gin Gin Ile 835 840 845 Lys Ile Thr Glu Leu Val Glu Asp Asn Lys Asp Asn Ile Ile Leu Ser 850 855 860 Ala Lys Ala Gin Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly 865 870 875 880 Ala Val Lys Lys Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp 885 890 895 Asn Trp Gin Asn Ile Lys Gin Val Leu Ser Ala Lys His Gin Leu His 900 905 910 Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu 915 920 925 Ala Asp Val Lys Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu 930 935 940 Glu Arg Ile Ser Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile 945 950 955 960 Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr 965 970 975 Page 220 of 3790 Asp Gly Asp Phe Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro 980 985 990 Arg Ser His Lys Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile 995 1000 1005 46 1064 PRT Bradyrhizobium sp. 46 Met Lys Arg Thr Ser Leu Arg Ala Tyr Arg Leu Gly Val Asp Leu Gly 15 10 15 Ala Asn Ser Leu Gly Trp Phe Val Val Trp Leu Asp Asp His Gly Gin 20 25 30 Pro Glu Gly Leu Gly Pro Gly Gly Val Arg Ile Phe Pro Asp Gly Arg 35 40 45 Asn Pro Gin Ser Lys Gin Ser Asn Ala Ala Gly Arg Arg Leu Ala Arg 50 55 60 Page 221 of 3790 Ser Ala Arg Arg Arg Arg Asp Arg Tyr Leu Gin Arg Arg Gly Lys Leu 65 70 75 80 Met Gly Leu Leu Val Lys His Gly Leu Met Pro Ala Asp Glu Pro Ala 85 90 95 Arg Lys Arg Leu Glu Cys Leu Asp Pro Tyr Gly Leu Arg Ala Lys Ala 100 105 110 Leu Asp Glu Val Leu Pro Leu His His Val Gly Arg Ala Leu Phe His 115 120 125 Leu Asn Gin Arg Arg Gly Leu Phe Ala Asn Arg Ala Ile Glu Gin Gly 130 135 140 Asp Lys Asp Ala Ser Ala Ile Lys Ala Ala Ala Gly Arg Leu Gin Thr 145 150 155 160 Ser Met Gin Ala Cys Gly Ala Arg Thr Leu Gly Glu Phe Leu Asn Arg 165 170 175 Arg His Gin Leu Arg Ala Thr Val Arg Ala Arg Ser Pro Val Gly Gly 180 185 190 Asp Val Gin Ala Arg Tyr Glu Phe Tyr Pro Thr Arg Ala Met Val Asp 195 200 205 Ala Glu Phe Glu Ala Ile Trp Ala Ala Gin Ala Pro His His Pro Thr 210 215 220 Met Thr Ala Glu Ala His Asp Thr Ile Arg Glu Ala Ile Phe Ser Gin 225 230 235 240 Arg Ala Met Lys Arg Pro Ser Ile Gly Lys Cys Ser Leu Asp Pro Ala 245 250 255 Thr Ser Gin Asp Asp Val Asp Gly Phe Arg Cys Ala Trp Ser His Pro 260 265 270 Leu Ala Gin Arg Phe Arg Ile Trp Gin Asp Val Arg Asn Leu Ala Val 275 280 285 Val Glu Thr Gly Pro Thr Ser Ser Arg Leu Gly Lys Glu Asp Gin Asp 290 295 300 Lys Val Ala Arg Ala Leu Leu Gin Thr Asp Gin Leu Ser Phe Asp Glu 305 310 315 320 Page 222 of 3790 Ile Arg Gly Leu Leu Gly Leu Pro Ser Asp Ala Arg Phe Asn Leu Glu 325 330 335 Ser Asp Arg Arg Asp His Leu Lys Gly Asp Ala Thr Gly Ala Ile Leu 340 345 350 Ser Ala Arg Arg His Phe Gly Pro Ala Trp His Asp Arg Ser Leu Asp 355 360 365 Arg Gin Ile Asp Ile Val Ala Leu Leu Glu Ser Ala Leu Asp Glu Ala 370 375 380 Ala Ile Ile Ala Ser Leu Gly Thr Thr His Ser Leu Asp Glu Ala Ala 385 390 395 400 Ala Gin Arg Ala Leu Ser Ala Leu Leu Pro Asp Gly Tyr Cys Arg Leu 405 410 415 Gly Leu Arg Ala Ile Lys Arg Val Leu Pro Leu Met Glu Ala Gly Arg 420 425 430 Thr Tyr Ala Glu Ala Ala Ser Ala Ala Gly Tyr Asp His Ala Leu Leu 435 440 445 Pro Gly Gly Lys Leu Ser Pro Thr Gly Tyr Leu Pro Tyr Tyr Gly Gin 450 455 460 Trp Leu Gin Asn Asp Val Val Gly Ser Asp Asp Glu Arg Asp Thr Asn 465 470 475 480 Glu Arg Arg Trp Gly Arg Leu Pro Asn Pro Thr Val His Ile Gly Ile 485 490 495 Gly Gin Leu Arg Arg Val Val Asn Glu Leu Ile Arg Trp His Gly Pro 500 505 510 Pro Ala Glu Ile Thr Val Glu Leu Thr Arg Asp Leu Lys Leu Ser Pro 515 520 525 Arg Arg Leu Ala Glu Leu Glu Arg Glu Gin Ala Glu Asn Gin Arg Lys 530 535 540 Asn Asp Lys Arg Thr Ser Leu Leu Arg Lys Leu Gly Leu Pro Ala Ser 545 550 555 560 Thr His Asn Leu Leu Lys Leu Arg Leu Trp Asp Glu Gin Gly Asp Val Page 224 of 3790 Arg Ile Gly Trp Thr Arg Pro Lys Lys Trp Pro 1055 1060 Page 225 of 3790 47 1354 PRT Flavobacterium psychrophilum 47 Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Phe Ile Asn Glu Ala Glu Asn Glu Ile Glu Val Ser Ser Ile Val 20 25 30 Asn Thr Gly Val Arg Ile Val Pro Leu Thr Thr Asp Glu Glu Ser Asp 35 40 45 Phe Lys Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 50 55 60 Arg Gly Ala Arg Arg Gly Leu Gin Arg Phe Lys Gin Arg Arg Glu Ala 65 70 75 80 Leu Leu Glu Thr Phe Asn Arg Ile Lys Phe Ile Ala Thr Asp Phe Val 85 90 95 Tyr Ala Glu Thr Gly Ala Ala Thr Thr Phe Ser Ser Tyr Gin Leu Arg 100 105 110 Ala Lys Ser Ala Val Glu Ala Val Thr Lys Glu Glu Leu Val Lys Val 115 120 125 Leu Leu Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 130 135 140 Lys Thr Ala Glu Glu Gly Asp Ala Ile Asp Gly Met Lys Ile Ala Lys 145 150 155 160 Glu Ile Phe Glu Asn Asn Leu Thr Pro Gly Gin Trp Val Tyr Asn Ser 165 170 175 Leu Ser Lys Gly Gly Lys Phe Ile Pro Asp Phe Tyr His Ser Asp Leu 180 185 190 Gin Lys Glu Leu Glu Lys Ile Val Arg Phe Gin Asn Gin Phe His Ser 195 200 205 Glu Gin Ile Asn Asp Lys Leu Leu Ala Asp Ile Gin Gly Lys Ser Arg 210 215 220 Page 226 of 3790 Thr Gin Thr Ser Gin His Phe Ser Lys Thr Leu Asn Ile Pro Leu Ala 225 230 235 240 Glu Asn Lys Gly Thr Arg Glu Glu Thr Lys Leu Gin His Tyr Gin Trp 245 250 255 Arg Asn Glu Ala Leu Ala Asn Glu Leu Asp Met Lys Ile Leu Ala Phe 260 265 270 Ile Ile Thr Glu Ile Asn Asn Gin Ile Asn Gin Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Gin Glu Thr 290 295 300 Val Gly Gin Tyr Gin Tyr Lys Gin Leu Gin Glu Asn Val His Ala Lys 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Lys Ile Trp Glu Thr Gin Ala Lys Phe His Ser Glu Leu Asn Glu Lys 340 345 350 Leu Lys Ala Glu Ile Arg Asp Ile Thr Ile Phe Tyr Gin Arg Lys Leu 355 360 365 Lys Ser Gin Lys His Leu Val Ser Phe Cys Glu Phe Glu Lys Gly His 370 375 380 Lys Ala Ile Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Arg Ile Trp 385 390 395 400 Gin Asn Leu Asn Asn Val Val Val Lys Asn Glu Thr Thr Lys Glu Val 405 410 415 Phe Glu Leu Ser Glu Glu Leu Lys Gin Leu Ile Ala Glu Glu Leu Gin 420 425 430 Phe Lys Glu Ser Met Thr Asp Val Gin Met Leu Thr Phe Cys Glu Leu 435 440 445 Lys Lys Gly Thr His Thr Val Asn Phe Lys Lys Ile Glu Gly Asn Arg 450 455 460 Thr Asn Thr Ser Ile Tyr Lys Ala Phe Glu Lys Ile Leu Glu Val Glu 465 470 475 480 Page 227 of 3790 Gly Tyr Glu Ile Asp Phe Ser Lys Met Lys Pro Leu Glu Ile Lys Glu 485 490 495 Thr Val Ala Pro Ile Phe Glu Thr Leu Asn Ile Asn Thr Val Ile Leu 500 505 510 Asp Phe Asp Pro Thr Ile Gin Gly Asn Asp Phe Asp Lys Gin Pro Tyr 515 520 525 Tyr Gin Leu Trp His Leu Leu Tyr Ser Ala Glu Asp Asp Asp Lys Leu 530 535 540 Lys Glu Thr Leu Lys Thr Lys Phe Gly Phe Lys Glu Asn His Leu Pro 545 550 555 560 Phe Ile Leu Asn Ile Asn Leu Gin Ala Asp Tyr Gly Ser Leu Ser Ala 565 570 575 Lys Ala Ile Lys Lys Ile Leu Pro His Leu Met Asp Gly His Ile Tyr 580 585 590 Asp Lys Ala Cys Leu Met Val Gly Tyr Asn His Ser Ser Ser Leu Thr 595 600 605 Thr Ala Gin Asn Asn Asp Arg Val Leu Lys Asp Thr Leu Glu Leu Leu 610 615 620 Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gin 625 630 635 640 Met Ile Asn Val Ile Asn Ala Ile Met Lys Asp Pro Ala Met Gly Lys 645 650 655 Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys Ala Asn Asn 660 665 670 Glu Gin Arg Lys Lys Ala Thr Ser Asp Ile Asn Thr Ala Thr Thr Glu 675 680 685 His Glu Arg Ile Arg Lys Leu Leu His Ser Glu Phe Asn Ile Pro Arg 690 695 700 Val Thr Arg Asn Asp Ile Ile Arg Tyr Lys Leu Trp Leu Glu Thr Gly 705 710 715 720 Gly Ile Ser Leu Tyr Thr Gly Asn Pro Ile Lys Ala Ser Asp Leu Phe Page 229 of 3790 Gin Leu Glu Ser Ile Leu Ile Ser Tyr Lys Ala Lys Asn Lys Val Val 980 985 990 Thr Lys Asn Lys Asn Thr Thr Lys Lys Ser Gly Gly Thr Asn Gin Lys 995 1000 1005 Page 230 of 3790 Tyr 48 1062 PRT Actinobacillus succinogenes 48 Met Asn Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile Ala Ser Val 15 10 15 Gly Trp Ala Val Val Glu Ile Asp Glu Gin Glu Asn Pro Gin Arg Leu 20 25 30 Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val Leu Lys Thr 35 40 45 Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ser Arg Arg 50 55 60 Page 231 of 3790 Leu Val Lys Arg Arg Ala Glu Arg Ile Lys Lys Ala Lys Arg Leu Leu 65 70 75 80 Lys Ala Glu Asn Leu Leu Leu Ser Ala Asp Glu Ile Leu Pro Asn Glu 85 90 95 Ala Trp Gin Leu Arg Val Lys Gly Leu Asp Gin Lys Leu Glu Arg Gin 100 105 110 Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg Gly Tyr Leu 115 120 125 Ser Gin Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu Gly Ala 130 135 140 Leu Leu Ser Gly Val Ala Ile Asn His Gin Ile Leu Gin Ser Ala Glu 145 150 155 160 Tyr Arg Thr Pro Ala Glu Ile Ala Val Asn Lys Phe Gin Ala Glu Glu 165 170 175 Gly His Ile Arg Asn Gin Arg Gly Ala Tyr Thr His Thr Phe Ser Arg 180 185 190 Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Gin Arg Gin Ala Thr 195 200 205 Leu Gly Asn Pro His Thr Ser Thr Lys Leu Leu Glu Asn Leu Thr Ala 210 215 220 Leu Leu Met Trp Gin Lys Pro Ala Leu Ala Gly Glu Ala Ile Leu Lys 225 230 235 240 Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys Ala Ala Lys 245 250 255 Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn 260 265 270 Leu Arg Ile Leu Glu Gin Gly Ala Glu Arg Ala Leu Thr Asp Asn Glu 275 280 285 Arg Phe Ala Leu Leu Asp Gin Pro Tyr Glu Lys Ala Lys Leu Thr Tyr 290 295 300 Ala Gin Val Arg Thr Leu Leu Gly Leu Ser Asp Glu Ala Ile Phe Lys 305 310 315 320 Page 232 of 3790 Gly Leu Arg Tyr Gin Gly Glu Asp Lys Lys Ala Val Glu Thr Lys Thr 325 330 335 Thr Leu Met Glu Val Lys Ala Tyr His Gin Ile Arg Lys Ala Leu Glu 340 345 350 Gly Leu Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn Asn Pro Ala 355 360 365 Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Asp 370 375 380 Asp Ile His Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser Val Leu Asn 385 390 395 400 Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gin Leu Ser Leu 405 410 415 Lys Ala Leu Gin Gin Ile Leu Pro Leu Met Leu Gin Gly Gin Arg Tyr 420 425 430 Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly Lys Lys Ser 435 440 445 Asp Glu Ile Asp Arg Leu Leu Pro Asn Ile Pro Thr Asp Glu Ile Arg 450 455 460 Asn Pro Val Val Leu Arg Thr Leu Thr Gin Ala Arg Lys Val Ile Asn 465 470 475 480 Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr 485 490 495 Gly Arg Glu Val Gly Lys Ser Tyr Gin Asp Arg Lys Lys Leu Glu Lys 500 505 510 Gin Gin Glu Glu Asn Arg Lys Gin Arg Glu Asn Ala Val Lys Lys Phe 515 520 525 Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly Lys Asp Ile 530 535 540 Leu Lys Met Arg Leu Tyr Glu Leu Gin Gin Ala Lys Cys Leu Tyr Ser 545 550 555 560 Gly Lys Ser Leu Glu Leu Tyr Arg Leu Leu Glu Lys Gly Tyr Val Glu 980 985 990 Lys Gly Glu 995 Ile Phe Gly Tyr Phe Asn Gly Leu Asp Arg Ala Thr Gly 1000 1005 Ser Ile Glu 1010 Ile Glu Glu His Asp Leu 1015 Glu Lys Ser Lys Gly Lys 1020 Asn Gly 1025 Ser His Arg Gly Leu 1030 Gly Val Lys Thr Ala 1035 Phe Phe Leu Glu Lys 1040 Tyr Gin Val Asp Glu 1045 Leu Gly Lys Asn Ile Arg Pro Cys 1050 Arg Pro Thr Lys Arg Gin His Val Arg 1055 1060 Page 235 of 3790 49 1340 PRT Dorea longicatena 49 Met Glu Gin Glu Tyr Tyr Leu Gly Leu Asp Met Gly Thr Gly Ser Val 15 10 15 Gly Trp Ala Val Thr Asp Ser Glu Tyr His Val Leu Arg Lys His Gly 20 25 30 Lys Ala Leu Trp Gly Val Arg Leu Phe Glu Ser Ala Ser Thr Ala Glu 35 40 45 Glu Arg Arg Met Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Asn 50 55 60 Trp Arg Ile Glu Ile Leu Gin Glu Ile Phe Ala Glu Glu Ile Ser Lys 65 70 75 80 Lys Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 85 90 95 Glu Asp Lys Arg Asp Ile Asn Gly Asn Cys Pro Glu Leu Pro Tyr Ala 100 105 110 Leu Phe Val Asp Asp Asp Phe Thr Asp Lys Asp Tyr His Lys Lys Phe 115 120 125 Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Asn Thr Glu Glu Thr 130 135 140 Pro Asp Ile Arg Leu Val Tyr Leu Ala Ile His His Met Met Lys His 145 150 155 160 Arg Gly His Phe Leu Leu Ser Gly Asp Ile Asn Glu Ile Lys Glu Phe 165 170 175 Gly Thr Thr Phe Ser Lys Leu Leu Glu Asn Ile Lys Asn Glu Glu Leu 180 185 190 Asp Trp Asn Leu 195 Glu Leu Gly Lys 200 Glu Glu Tyr Ala Val 205 Val Glu Ser Ile Leu Lys Asp Asn Met Leu Asn Arg Ser Thr Lys Lys Thr Arg Leu 210 215 220 Page 236 of 3790 Ile Lys Ala Leu Lys Ala Lys Ser Ile Cys Glu Lys Ala Val Leu Asn 225 230 235 240 Leu Leu Ala Gly Gly Thr Val Lys Leu Ser Asp Ile Phe Gly Leu Glu 245 250 255 Glu Leu Asn Glu Thr Glu Arg Pro Lys Ile Ser Phe Ala Asp Asn Gly 260 265 270 Tyr Asp Asp Tyr Ile Gly Glu Val Glu Asn Glu Leu Gly Glu Gin Phe 275 280 285 Tyr Ile Ile Glu Thr Ala Lys Ala Val Tyr Asp Trp Ala Val Leu Val 290 295 300 Glu Ile Leu Gly Lys Tyr Thr Ser Ile Ser Glu Ala Lys Val Ala Thr 305 310 315 320 Tyr Glu Lys His Lys Ser Asp Leu Gin Phe Leu Lys Lys Ile Val Arg 325 330 335 Lys Tyr Leu Thr Lys Glu Glu Tyr Lys Asp Ile Phe Val Ser Thr Ser 340 345 350 Asp Lys Leu Lys Asn Tyr Ser Ala Tyr Ile Gly Met Thr Lys Ile Asn 355 360 365 Gly Lys Lys Val Asp Leu Gin Ser Lys Arg Cys Ser Lys Glu Glu Phe 370 375 380 Tyr Asp Phe Ile Lys Lys Asn Val Leu Lys Lys Leu Glu Gly Gin Pro 385 390 395 400 Glu Tyr Glu Tyr Leu Lys Glu Glu Leu Glu Arg Glu Thr Phe Leu Pro 405 410 415 Lys Gin Val Asn Arg Asp Asn Gly Val Ile Pro Tyr Gin Ile His Leu 420 425 430 Tyr Glu Leu Lys Lys Ile Leu Gly Asn Leu Arg Asp Lys Ile Asp Leu 435 440 445 Ile Lys Glu Asn Glu Asp Lys Leu Val Gin Leu Phe Glu Phe Arg Ile 450 455 460 Pro Tyr Tyr Val Gly Pro Leu Asn Lys Ile Asp Asp Gly Lys Glu Gly 465 470 475 480 Page 237 of 3790 Lys Phe Thr Trp Ala Val Arg Lys Ser Asn Glu Lys Ile Tyr Pro Trp 485 490 495 Asn Phe Glu Asn Val Val Asp Ile Glu Ala Ser Ala Glu Lys Phe Ile 500 505 510 Arg Arg Met Thr Asn Lys Cys Thr Tyr Leu Met Gly Glu Asp Val Leu 515 520 525 Pro Lys Asp Ser Leu Leu Tyr Ser Lys Tyr Met Val Leu Asn Glu Leu 530 535 540 Asn Asn Val Lys Leu Asp Gly Glu Lys Leu Ser Val Glu Leu Lys Gin 545 550 555 560 Arg Leu Tyr Thr Asp Val Phe Cys Lys Tyr Arg Lys Val Thr Val Lys 565 570 575 Lys Ile Lys Asn Tyr Leu Lys Cys Glu Gly Ile Ile Ser Gly Asn Val 580 585 590 Glu Ile Thr Gly Ile Asp Gly Asp Phe Lys Ala Ser Leu Thr Ala Tyr 595 600 605 His Asp Phe Lys Glu Ile Leu Thr Gly Thr Glu Leu Ala Lys Lys Asp 610 615 620 Lys Glu Asn Ile Ile Thr Asn Ile Val Leu Phe Gly Asp Asp Lys Lys 625 630 635 640 Leu Leu Lys Lys Arg Leu Asn Arg Leu Tyr Pro Gin Ile Thr Pro Asn 645 650 655 Gin Leu Lys Lys Ile Cys Ala Leu Ser Tyr Thr Gly Trp Gly Arg Phe 660 665 670 Ser Lys Lys Phe Leu Glu Glu Ile Thr Ala Pro Asp Pro Glu Thr Gly 675 680 685 Glu Val Trp Asn Ile Ile Thr Ala Leu Trp Glu Ser Asn Asn Asn Leu 690 695 700 Met Gin Leu Leu Ser Asn Glu Tyr Arg Phe Met Glu Glu Val Glu Thr 705 710 715 720 Tyr Asn Met Gly Lys Gin Thr Lys Thr Leu Ser Tyr Glu Thr Val Glu Page 239 of 3790 Arg Glu Val Asn Asp Leu His His Ala Lys Asp Ala Tyr Leu Asn Ile 980 985 990 Val Val Gly Asn Ser Tyr Tyr Val Lys Phe Thr Lys Asn Ala Ser Trp 995 1000 1005 Page 240 of 3790 Lys Ile 1340 50 984 PRT Campylobacter jejuni 50 Met Ala Lys Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu 20 Leu Lys Asp Cys Gly Val Arg 30 Ile Phe Thr Lys Ala 35 Glu Asn Pro Lys Thr Gly Glu 40 Ser Leu Ala Leu 45 Pro Arg Arg Ile Ala Arg 50 Ser Ala Arg 55 Lys Arg Leu Ala Arg Arg 60 Lys Ala Arg Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Page 241 of 3790 Glu Asp Tyr Gin Ser Phe Asp Glu Ile Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Leu Tyr Thr Lys Asp Asp Leu 275 280 285 Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu Thr Tyr Lys 290 295 300 Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu Phe Lys Gly 305 310 315 320 Glu Lys Gly Asn Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu Phe Ile 325 330 335 Page 242 of 3790 Lys Ala Leu Gly Glu His Ser Leu Ser Gin Asp Asp Leu Asn Glu Ile 340 345 350 Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu Lys Lys Ala 355 360 365 Leu Ala Lys Tyr Asp Leu Asn Glu Asn Gin Ile Asp Asn Leu Ser Lys 370 375 380 Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu Lys Leu 385 390 395 400 Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu Ala Cys Asn 405 410 415 Glu Leu Thr Leu Lys Val Ala Ile Asn Glu Asp Lys Lys Asp Phe Leu 420 425 430 Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr Asn Pro Val 435 440 445 Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu 450 455 460 Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala Arg Glu 465 470 475 480 Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys Glu Gin Asn 485 490 495 Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Lys Leu 500 505 510 Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe Lys 515 520 525 Glu Gin Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile Lys Leu Ser 530 535 540 Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile Tyr Pro Tyr 545 550 555 560 Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu Val Phe Thr 565 570 575 Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu Ala Phe Gly Page 244 of 3790 Page 245 of 3790 Arg Arg Arg Ile Arg Arg Lys Ala Leu Asn Glu Thr Leu His Glu Ala 65 70 75 80 Gly Phe Leu Pro Ala Tyr Gly Ser Ala Asp Trp Pro Val Val Met Ala 85 90 95 Asp Glu Pro Tyr Glu Leu Arg Arg Arg Gly Leu Glu Glu Gly Leu Ser 100 105 110 Ala Tyr Glu Phe Gly Arg Ala Ile Tyr His Leu Ala Gin His Arg His 115 120 125 Phe Lys Gly Arg Glu Leu Glu Glu Ser Asp Thr Pro Asp Pro Asp Val 130 135 140 Asp Asp Glu Lys Glu Ala Ala Asn Glu Arg Ala Ala Thr Leu Lys Ala 145 150 155 160 Leu Lys Asn Glu Gin Thr Thr Leu Gly Ala Trp Leu Ala Arg Arg Pro 165 170 175 Pro Ser Asp Arg Lys Arg Gly Ile His Ala His Arg Asn Val Val Ala 180 185 190 Glu Glu Phe Glu Arg Leu Trp Glu Val Gin Ser Lys Phe His Pro Ala 195 200 205 Leu Lys Ser Glu Glu Met Arg Ala Arg Ile Ser Asp Thr Ile Phe Ala 210 215 220 Gin Arg Pro Val Phe Trp Arg Lys Asn Thr Leu Gly Glu Cys Arg Phe 225 230 235 240 Met Pro Gly Glu Pro Leu Cys Pro Lys Gly Ser Trp Leu Ser Gin Gin 245 250 255 Arg Arg Met Leu Glu Lys Leu Asn Asn Leu Ala Ile Ala Gly Gly Asn 260 265 270 Ala Arg Pro Leu Asp Ala Glu Glu Arg Asp Ala Ile Leu Ser Lys Leu 275 280 285 Gin Gin Gin Ala Ser Met Ser Trp Pro Gly Val Arg Ser Ala Leu Lys 290 295 300 Ala Leu Tyr Lys Gin Arg Gly Glu Pro Gly Ala Glu Lys Ser Leu Lys 305 310 315 320 Page 246 of 3790 Phe Asn Leu Glu Leu Gly Gly Glu Ser Lys Leu Leu Gly Asn Ala Leu 325 330 335 Glu Ala Lys Leu Ala Asp Met Phe Gly Pro Asp Trp Pro Ala His Pro 340 345 350 Arg Lys Gin Glu Ile Arg His Ala Val His Glu Arg Leu Trp Ala Ala 355 360 365 Asp Tyr Gly Glu Thr Pro Asp Lys Lys Arg Val Ile Ile Leu Ser Glu 370 375 380 Lys Asp Arg Lys Ala His Arg Glu Ala Ala Ala Asn Ser Phe Val Ala 385 390 395 400 Asp Phe Gly Ile Thr Gly Glu Gin Ala Ala Gin Leu Gin Ala Leu Lys 405 410 415 Leu Pro Thr Gly Trp Glu Pro Tyr Ser Ile Pro Ala Leu Asn Leu Phe 420 425 430 Leu Ala Glu Leu Glu Lys Gly Glu Arg Phe Gly Ala Leu Val Asn Gly 435 440 445 Pro Asp Trp Glu Gly Trp Arg Arg Thr Asn Phe Pro His Arg Asn Gin 450 455 460 Pro Thr Gly Glu Ile Leu Asp Lys Leu Pro Ser Pro Ala Ser Lys Glu 465 470 475 480 Glu Arg Glu Arg Ile Ser Gin Leu Arg Asn Pro Thr Val Val Arg Thr 485 490 495 Gin Asn Glu Leu Arg Lys Val Val Asn Asn Leu Ile Gly Leu Tyr Gly 500 505 510 Lys Pro Asp Arg Ile Arg Ile Glu Val Gly Arg Asp Val Gly Lys Ser 515 520 525 Lys Arg Glu Arg Glu Glu Ile Gin Ser Gly Ile Arg Arg Asn Glu Lys 530 535 540 Gin Arg Lys Lys Ala Thr Glu Asp Leu Ile Lys Asn Gly Ile Ala Asn 545 550 555 560 Pro Ser Arg Asp Asp Val Glu Lys Trp Ile Leu Trp Lys Glu Gly Gin 565 570 575 Page 247 of 3790 Glu Arg Cys Pro Tyr Thr Gly Asp Gin Ile Gly Phe Asn Ala Leu Phe 580 585 590 Arg Glu Gly Arg Tyr Glu Val Glu His Ile Trp Pro Arg Ser Arg Ser 595 600 605 Phe Asp Asn Ser Pro Arg Asn Lys Thr Leu Cys Arg Lys Asp Val Asn 610 615 620 Ile Glu Lys Gly Asn Arg Met Pro Phe Glu Ala Phe Gly His Asp Glu 625 630 635 640 Asp Arg Trp Ser Ala Ile Gin Ile Arg Leu Gin Gly Met Val Ser Ala 645 650 655 Lys Gly Gly Thr Gly Met Ser Pro Gly Lys Val Lys Arg Phe Leu Ala 660 665 670 Lys Thr Met Pro Glu Asp Phe Ala Ala Arg Gin Leu Asn Asp Thr Arg 675 680 685 Tyr Ala Ala Lys Gin Ile Leu Ala Gin Leu Lys Arg Leu Trp Pro Asp 690 695 700 Met Gly Pro Glu Ala Pro Val Lys Val Glu Ala Val Thr Gly Gin Val 705 710 715 720 Thr Ala Gin Leu Arg Lys Leu Trp Thr Leu Asn Asn Ile Leu Ala Asp 725 730 735 Asp Gly Glu Lys Thr Arg Ala Asp His Arg His His Ala Ile Asp Ala 740 745 750 Leu Thr Val Ala Cys Thr His Pro Gly Met Thr Asn Lys Leu Ser Arg 755 760 765 Tyr Trp Gin Leu Arg Asp Asp Pro Arg Ala Glu Lys Pro Ala Leu Thr 770 775 780 Pro Pro Trp Asp Thr Ile Arg Ala Asp Ala Glu Lys Ala Val Ser Glu 785 790 795 800 Ile Val Val Ser His Arg Val Arg Lys Lys Val Ser Gly Pro Leu His 805 810 815 Lys Glu Thr Thr Tyr Gly Asp Thr Gly Thr Asp Ile Lys Thr Lys Ser 820 Page 248 of 3790 825 830 52 1107 PRT Eubacterium ventriosum 52 Met Gly Tyr Thr Val Gly Leu Asp Ile Gly Val Ala Ser Val Gly Val Page 250 of 3790 Lys Cys Ser Val Tyr Pro Glu Glu Tyr Arg Ala Ser Ser Ala Ser Tyr 260 265 270 Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Lys Ile 275 280 285 Asn Asn Glu Lys Leu Thr Glu Phe Gin Lys Lys Glu Ile Val Glu Ile 290 295 300 Ile Lys Asp Ala Ser Ser Val Asn Met Arg Lys Ile Ile Lys Lys Val 305 310 315 320 Ile Asp Glu Asp Ile Glu Gin Tyr Ser Gly Ala Arg Ile Asp Lys Lys 325 330 335 Gly Lys Glu Ile Tyr His Thr Phe Glu Ile Tyr Arg Lys Leu Lys Lys 340 345 350 Glu Leu Lys Thr Ile Asn Val Asp Ile Asp Ser Phe Thr Arg Glu Glu 355 360 365 Leu Asp Lys Thr Met Asp Ile Leu Thr Leu Asn Thr Glu Arg Glu Ser 370 375 380 Ile Val Lys Ala Phe Asp Glu Gin Lys Phe Val Tyr Glu Glu Asn Leu 385 390 395 400 Ile Lys Lys Leu Ile Glu Phe Arg Lys Asn Asn Gin Arg Leu Phe Ser 405 410 415 Gly Trp His Ser Phe Ser Tyr Lys Ala Met Leu Gin Leu Ile Pro Val 420 425 430 Met Tyr Lys Glu Pro Lys Glu Gin Met Gin Leu Leu Thr Glu Met Asn 435 440 445 Val Phe Lys Ser Lys Lys Glu Lys Tyr Val Asn Tyr Lys Tyr Ile Pro 450 455 460 Glu Asn Glu Val Val Lys Glu Ile Tyr Asn Pro Val Val Val Lys Ser 465 470 475 480 Ile Arg Thr Thr Val Lys Ile Leu Asn Ala Leu Ile Lys Lys Tyr Gly 485 490 495 Tyr Pro Glu Ser Val Val Ile Glu Met Pro Arg Asp Lys Asn Ser Asp 500 505 510 Page 251 of 3790 Asp Glu Lys Glu Lys Ile Asp Met Asn Gin Lys Lys Asn Gin Glu Glu 515 520 525 Tyr Glu Lys Ile Leu Asn Lys Ile Tyr Asp Glu Lys Gly Ile Glu Ile 530 535 540 Thr Asn Lys Asp Tyr Lys Lys Gin Lys Lys Leu Val Leu Lys Leu Lys 545 550 555 560 Leu Trp Asn Glu Gin Glu Gly Leu Cys Leu Tyr Ser Gly Lys Lys Ile 565 570 575 Ala Ile Glu Asp Leu Leu Asn His Pro Glu Phe Phe Glu Ile Asp His 580 585 590 Ile Ile Pro Lys Ser Ile Ser Leu Asp Asp Ser Arg Ser Asn Lys Val 595 600 605 Leu Val Tyr Lys Thr Glu Asn Ser Ile Lys Glu Asn Asp Thr Pro Tyr 610 615 620 His Tyr Leu Thr Arg Ile Asn Gly Lys Trp Gly Phe Asp Glu Tyr Lys 625 630 635 640 Ala Asn Val Leu Glu Leu Arg Arg Arg Gly Lys Ile Asp Asp Lys Lys 645 650 655 Val Asn Asn Leu Leu Cys Met Glu Asp Ile Thr Lys Ile Asp Val Val 660 665 670 Lys Gly Phe Ile Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg 675 680 685 Val Val Leu Asn Glu Met Gin Ser Phe Phe Glu Ser Arg Lys Tyr Cys 690 695 700 Asn Thr Lys Val Lys Val Ile Arg Gly Ser Leu Thr Tyr Gin Met Arg 705 710 715 720 Gin Asp Leu His Leu Lys Lys Asn Arg Glu Glu Ser Tyr Ser His His 725 730 735 Ala Val Asp Ala Met Leu Ile Ala Phe Ser Gin Lys Gly Tyr Glu Ala 740 745 750 Tyr Arg Lys Ile Gin Lys Asp Cys Tyr Asp Phe Glu Thr Gly Glu Ile 755 760 765 Page 252 of 3790 Ser Lys Asn Ile Thr Tyr Lys Phe Ser Leu Tyr Lys Asn Asp Ile Page 253 of 3790 1010 1015 1020 1100 1105 53 1136 PRT Streptococcus gordonii 53 Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly Page 254 of 3790 115 120 125 Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 130 135 140 Leu Leu Ala Glu Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Phe Glu 145 150 155 160 Lys Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Glu Asn Gly Glu 165 170 175 Lys His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 180 185 190 Ala Glu Arg Ile Leu Arg Lys Gin Gin Glu Phe Asn Ser Lys Ile Thr 195 200 205 Asp Glu Phe Ile Glu Asp Tyr Leu Ile Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Thr Glu Glu Tyr Arg Ala Ser Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Lys Leu Ile 290 295 300 Ile Glu Tyr Ala Lys Ser Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 305 310 315 320 Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gin Ile Arg Gly 325 330 335 Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 340 345 350 Tyr Arg Lys Met Gin Ser Leu Glu Thr Ile Lys Val Glu Glu Leu Pro 355 360 365 Page 256 of 3790 Gly Gin Arg Thr Pro Phe Gin Ala Leu Asp Ser Met Asp Asp Ala Trp 625 630 635 640 Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Ser Lys Leu Leu Ser 645 650 655 Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 660 665 670 Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 675 680 685 Ser Ser Arg Val Val Leu Asn Ala Leu Gin Asp Phe Tyr Lys Ser His 690 695 700 Gin Leu Asp Thr Thr Ile Ser Val Val Arg Gly Gin Phe Thr Ser Gin 705 710 715 720 Leu Arg Arg Lys Trp Gly Ile Glu Lys Ser Arg Glu Thr Tyr His His 725 730 735 His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg Leu 740 745 750 Trp Lys Lys His Ser Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gin Phe 755 760 765 Val Asp Ser Glu Thr Gly Glu Ile Val Ser Leu Ser Asp Glu Glu Tyr 770 775 780 Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 785 790 795 800 Arg Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp 805 810 815 Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 820 825 830 Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 835 840 845 Lys Ile Lys Asp 850 Ile Tyr Ala Leu 855 Gly Thr Lys Thr Pro 860 Ser Lys Thr Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Lys Thr Asp Lys Ser Gin Phe 865 870 875 880 Page 257 of 3790 Lys Tyr Ala Asp 995 Leu Cys Phe Glu Glu Gly Gly Ala Tyr Gly Ile Ser 1000 1005 Glu Val Lys 1010 Tyr Lys Lys Ile Arg Glu 1015 Lys Glu Gly 1020 Ile Gly Lys Asn Ser 1025 Glu Phe Lys Phe Thr 1030 Leu Tyr Lys Asn Asp 1035 Leu Ile Leu Ile Lys Asp 1040 Thr Glu Thr Asn 1045 Cys Gin Gin Phe Phe Arg Phe 1050 Trp Ser Arg 1055 Thr Gly Lys Asp Asn 1060 Pro Lys Ser Phe Glu Lys His 1065 Lys Ile Glu 1070 Leu Lys Pro Tyr Glu 1075 Lys Ala Lys Phe Glu 1080 Lys Gly Glu Glu Leu 1085 Lys Val Leu Gly Lys 1090 Val Pro Pro Ser Ser Asn Gin Phe 1095 Gin Lys 1100 Asn Met Gin Ile Glu 1105 Asn Leu Ser Ile Tyr 1110 Lys Val Lys Thr Asp Ile Leu Gly Asn Lys His Phe Ile Lys Lys Glu Gly Asp Page 258 of 3790 1115 1120 1125 Glu Pro Lys Leu Lys Phe Lys Lys 1130 1135 54 984 PRT Campylobacter jejuni 54 Arg Cys Ile Thr Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe Page 259 of 3790 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Page 261 of 3790 Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Val Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Page 262 of 3790 Page 263 of 3790 Asn Arg Gly Gly Pro Asp Gly Lys Glu Glu Ala Gly Tyr Asp Phe Tyr 195 200 205 Pro Asp Arg Arg His Leu Glu Glu Glu Phe His Lys Leu Trp Ala Ala 210 215 220 Gin Gly Ala His His Pro Glu Leu Thr Glu Thr Leu Arg Asp Leu Leu 225 230 235 240 Phe Glu Lys Ile Phe Phe Gin Arg Pro Leu Lys Glu Pro Glu Val Gly 245 250 255 Leu Cys Leu Phe Ser Gly His His Gly Val Pro Pro Lys Asp Pro Arg 260 265 270 Leu Pro Lys Ala His Pro Leu Thr Gin Arg Arg Val Leu Tyr Glu Thr 275 280 285 Val Asn Gin Leu Arg Val Thr Ala Asp Gly Arg Glu Ala Arg Pro Leu 290 295 300 Thr Arg Glu Glu Arg Asp Gin Val Ile His Ala Leu Asp Asn Lys Lys 305 310 315 320 Pro Thr Lys Ser Leu Ser Ser Met Val Leu Lys Leu Pro Ala Leu Ala 325 330 335 Lys Val Leu Lys Leu Arg Asp Gly Glu Arg Phe Thr Leu Glu Thr Gly 340 345 350 Val Arg Asp Ala Ile Ala Cys Asp Pro Leu Arg Ala Ser Pro Ala His 355 360 365 Pro Asp Arg Phe Gly Pro Arg Trp Ser Ile Leu Asp Ala Asp Ala Gin 370 375 380 Trp Glu Val Ile Ser Arg Ile Arg Arg Val Gin Ser Asp Ala Glu His 385 390 395 400 Ala Ala Leu Val Asp Trp Leu Thr Glu Ala His Gly Leu Asp Arg Ala 405 410 415 His Ala Glu Ala Thr Ala His Ala Pro Leu Pro Asp Gly Tyr Gly Arg 420 425 430 Leu Gly Leu Thr Ala Thr Thr Arg Ile Leu Tyr Gin Leu Thr Ala Asp Page 264 of 3790 435 440 445 Val Val Thr Tyr Ala Asp Ala Val Lys Ala Cys Gly Trp His His Ser 450 455 460 Asp Gly Arg Thr Gly Glu Cys Phe Asp Arg Leu Pro Tyr Tyr Gly Glu 465 470 475 480 Val Leu Glu Arg His Val Ile Pro Gly Ser Tyr His Pro Asp Asp Asp 485 490 495 Asp Ile Thr Arg Phe Gly Arg Ile Thr Asn Pro Thr Val His Ile Gly 500 505 510 Leu Asn Gin Leu Arg Arg Leu Val Asn Arg Ile Ile Glu Thr His Gly 515 520 525 Lys Pro His Gin Ile Val Val Glu Leu Ala Arg Asp Leu Lys Lys Ser 530 535 540 Glu Glu Gin Lys Arg Ala Asp Ile Lys Arg Ile Arg Asp Thr Thr Glu 545 550 555 560 Ala Ala Lys Lys Arg Ser Glu Lys Leu Glu Glu Leu Glu Ile Glu Asp 565 570 575 Asn Gly Arg Asn Arg Met Leu Leu Arg Leu Trp Glu Asp Leu Asn Pro 580 585 590 Asp Asp Ala Met Arg Arg Phe Cys Pro Tyr Thr Gly Thr Arg Ile Ser 595 600 605 Ala Ala Met Ile Phe Asp Gly Ser Cys Asp Val Asp His Ile Leu Pro 610 615 620 Tyr Ser Arg Thr Leu Asp Asp Ser Phe Pro Asn Arg Thr Leu Cys Leu 625 630 635 640 Arg Glu Ala Asn Arg Gin Lys Arg Asn Gin Thr Pro Trp Gin Ala Trp 645 650 655 Gly Asp Thr Pro His Trp His Ala Ile Ala Ala Asn Leu Lys Asn Leu 660 665 670 Pro Glu Asn Lys Arg Trp Arg Phe Ala Pro Asp Ala Met Thr Arg Phe 675 680 685 Page 266 of 3790 1070 1075 56 1096 PRT Eubacterium dolichum 56 Met Met Glu Val Phe Met Gly Arg Leu Val Leu Gly Leu Asp Ile Gly 15 10 15 Ile Thr Ser Val Gly Phe Gly Ile Ile Asp Leu Asp Glu Ser Glu Ile 20 25 30 Val Asp Tyr Gly Val Arg Leu Phe Lys Glu Gly Thr Ala Ala Glu Asn 35 40 45 Glu Thr Arg Arg Thr Lys Arg Gly Gly Arg Arg Leu Lys Arg Arg Arg 50 55 60 Val Thr Arg Arg Glu Asp Met Leu His Leu Leu Lys Gin Ala Gly Ile 65 70 75 80 Page 267 of 3790 Ile Ser Thr Ser Phe His Pro Leu Asn Asn Pro Tyr Asp Val Arg Val 85 90 95 Lys Gly Leu Asn Glu Arg Leu Asn Gly Glu Glu Leu Ala Thr Ala Leu 100 105 110 Leu His Leu Cys Lys His Arg Gly Ser Ser Val Glu Thr Ile Glu Asp 115 120 125 Asp Glu Ala Lys Ala Lys Glu Ala Gly Glu Thr Lys Lys Val Leu Ser 130 135 140 Met Asn Asp Gin Leu Leu Lys Ser Gly Lys Tyr Val Cys Glu Ile Gin 145 150 155 160 Lys Glu Arg Leu Arg Thr Asn Gly His Ile Arg Gly His Glu Asn Asn 165 170 175 Phe Lys Thr Arg Ala Tyr Val Asp Glu Ala Phe Gin Ile Leu Ser His 180 185 190 Gin Asp Leu Ser Asn Glu Leu Lys Ser Ala Ile Ile Thr Ile Ile Ser 195 200 205 Arg Lys Arg Met Tyr Tyr Asp Gly Pro Gly Gly Pro Leu Ser Pro Thr 210 215 220 Pro Tyr Gly Arg Tyr Thr Tyr Phe Gly Gin Lys Glu Pro Ile Asp Leu 225 230 235 240 Ile Glu Lys Met Arg Gly Lys Cys Ser Leu Phe Pro Asn Glu Pro Arg 245 250 255 Ala Pro Lys Leu Ala Tyr Ser Ala Glu Leu Phe Asn Leu Leu Asn Asp 260 265 270 Leu Asn Asn Leu Ser Ile Glu Gly Glu Lys Leu Thr Ser Glu Gin Lys 275 280 285 Ala Met Ile Leu Lys Ile Val His Glu Lys Gly Lys Ile Thr Pro Lys 290 295 300 Gin Leu Ala Lys Glu Val Gly Val Ser Leu Glu Gin Ile Arg Gly Phe 305 310 315 320 Arg Ile Asp Thr Lys Gly Ser Pro Leu Leu Ser Glu Leu Thr Gly Tyr 325 330 335 Page 268 of 3790 Lys Met Ile Arg Glu Val Leu Glu Lys Ser Asn Asp Glu His Leu Glu 340 345 350 Asp His Val Phe Tyr Asp Glu Ile Ala Glu Ile Leu Thr Lys Thr Lys 355 360 365 Asp Ile Glu Gly Arg Lys Lys Gin Ile Ser Glu Leu Ser Ser Asp Leu 370 375 380 Asn Glu Glu Ser Val His Gin Leu Ala Gly Leu Thr Lys Phe Thr Ala 385 390 395 400 Tyr His Ser Leu Ser Phe Lys Ala Leu Arg Leu Ile Asn Glu Glu Met 405 410 415 Leu Lys Thr Glu Leu Asn Gin Met Gin Ser Ile Thr Leu Phe Gly Leu 420 425 430 Lys Gin Asn Asn Glu Leu Ser Val Lys Gly Met Lys Asn Ile Gin Ala 435 440 445 Asp Asp Thr Ala Ile Leu Ser Pro Val Ala Lys Arg Ala Gin Arg Glu 450 455 460 Thr Phe Lys Val Val Asn Arg Leu Arg Glu Ile Tyr Gly Glu Phe Asp 465 470 475 480 Ser Ile Val Val Glu Met Ala Arg Glu Lys Asn Ser Glu Glu Gin Arg 485 490 495 Lys Ala Ile Arg Glu Arg Gin Lys Phe Phe Glu Met Arg Asn Lys Gin 500 505 510 Val Ala Asp Ile Ile Gly Asp Asp Arg Lys Ile Asn Ala Lys Leu Arg 515 520 525 Glu Lys Leu Val Leu Tyr Gin Glu Gin Asp Gly Lys Thr Ala Tyr Ser 530 535 540 Leu Glu Pro Ile Asp Leu Lys Leu Leu Ile Asp Asp Pro Asn Ala Tyr 545 550 555 560 Glu Val Asp His Ile Ile Pro Ile Ser Ile Ser Leu Asp Asp Ser Ile 565 570 575 Thr Asn Lys Val Leu Val Thr His Arg Glu Asn Gin Glu Lys Gly Asn Page 270 of 3790 Page 271 of 3790 Tyr Lys Val Lys Lys Asn Thr Leu Lys Phe Glu Phe Asp 1085 1090 1095 57 1082 PRT Neisseria meningitidis 57 Met Ala Ala Phe Lys Pro Asn Pro 1 5 Ile Asn Tyr Ile Leu Gly Leu Asp 10 15 Ile Gly Ile Ala Ser Val Gly Trp 20 Ala Met Val Glu Ile Asp Glu Asp 25 30 Glu Asn Pro Ile Cys Leu Ile Asp 35 40 Leu Gly Val Arg Val Phe Glu Arg 45 Ala Glu Val Pro Lys Thr Gly Asp 50 55 Ser Leu Ala Met Ala Arg Arg Leu 60 Ala Arg Ser Val Arg Arg Leu Thr 65 70 Arg Arg Arg Ala His Arg Leu Leu 75 80 Arg Ala Arg Arg Leu Leu Lys Arg 85 Glu Gly Val Leu Gin Ala Ala Asp 90 95 Phe Asp Glu Asn Gly Leu Ile Lys 100 Ser Leu Pro Asn Thr Pro Trp Gin 105 110 Leu Arg Ala Ala Ala Leu Asp Arg 115 120 Lys Leu Thr Pro Leu Glu Trp Ser 125 Ala Val Leu Leu His Leu Ile Lys 130 135 His Arg Gly Tyr Leu Ser Gin Arg 140 Lys Asn Glu Gly Glu Thr Ala Asp 145 150 Lys Glu Leu Gly Ala Leu Leu Lys 155 160 Gly Val Ala Asp Asn Ala His Ala 165 Leu Gin Thr Gly Asp Phe Arg Thr 170 175 Pro Ala Glu Leu Ala Leu Asn Lys 180 Phe Glu Lys Glu Ser Gly His Ile 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser 195 200 His Thr Phe Ser Arg Lys Asp Leu 205 Page 272 of 3790 Gin Ala Glu Leu Asn Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Thr Thr 290 295 300 Leu Ile Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Glu Leu Asp Asn Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Asp Leu 450 455 460 Page 273 of 3790 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Thr Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp His Met Leu Leu Thr 675 680 685 Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp Page 275 of 3790 Leu Val Pro Ile Tyr Ser Trp Gin Val Ala Lys Gly Ile Leu Pro Asp 965 970 975 Arg Ala Val Val Gin Gly Lys Asp Glu Glu Asp Trp Gin Leu Ile Asp 980 985 990 Asp Ser Phe Asn Phe Lys Phe Ser Leu His Pro Asn Asp Leu Val Glu 995 1000 1005 Glu Ile Arg Pro 1070 Cys Arg Leu 1075 Lys Lys Arg Pro Pro 1080 Val Arg 58 1050 PRT Gluconacetobacter diazotrophicus 58 Met Gly Glu Asn Met Ile Asp Glu Ser Leu Thr Phe Gly Ile Asp Leu 15 10 15 Gly Ile Gly Ser Cys 20 Gly Trp Ala Val 25 Leu Arg Arg Pro Ser Ala Phe 30 Gly Arg Lys 35 Gly Val Ile Glu Gly Met Gly 40 Ser Trp Cys 45 Phe Asp Val Pro Glu Thr 50 Ser Lys Glu Arg Thr 55 Pro Thr Asn Gin 60 Ile Arg Arg Ser Asn Arg Leu 65 Leu Arg Arg Val 70 Ile Arg Arg Arg 75 Arg Asn Arg Met Ala Ala Ile Arg Arg Leu Leu His Ala Ala Gly Leu Leu Pro Ser Thr Asp 85 90 95 Page 276 of 3790 Ser Asp Ala Leu Lys Arg Pro Gly His Asp Pro Trp Glu Leu Arg Ala 100 105 110 Arg Gly Leu Asp Lys Pro Leu Lys Pro Val Glu Phe Ala Val Val Leu 115 120 125 Gly His Ile Ala Lys Arg Arg Gly Phe Lys Ser Ala Ala Lys Arg Lys 130 135 140 Ala Thr Asn Ile Ser Ser Asp Asp Lys Lys Met Leu Thr Ala Leu Glu 145 150 155 160 Ala Thr Arg Glu Arg Leu Gly Arg Tyr Arg Thr Val Gly Glu Met Phe 165 170 175 Ala Arg Asp Pro Asp Phe Ala Ser Arg Arg Arg Asn Arg Glu Gly Lys 180 185 190 Tyr Asp Arg Thr Thr Ala Arg Asp Asp Leu Glu His Glu Val His Ala 195 200 205 Leu Phe Ala Ala Gin Arg Arg Leu Gly Gin Gly Phe Ala Ser Pro Glu 210 215 220 Leu Glu Glu Ala Phe Thr Ala Ser Ala Phe His Gin Arg Pro Met Gin 225 230 235 240 Asp Ser Glu Arg Leu Val Gly Phe Cys Pro Phe Glu Arg Thr Glu Lys 245 250 255 Arg Ala Ala Lys Leu Thr Pro Ser Phe Glu Arg Phe Arg Leu Leu Ala 260 265 270 Arg Leu Leu Asn Leu Arg Ile Thr Thr Pro Asp Gly Glu Arg Pro Leu 275 280 285 Thr Val Asp Glu Ile Ala Leu Val Thr Arg Asp Leu Gly Lys Thr Ala 290 295 300 Lys Leu Ser Ile Lys Arg Val Arg Thr Leu Ile Gly Leu Glu Asp Asn 305 310 315 320 Gin Arg Phe Thr Thr Ile Arg Pro Glu Asp Glu Asp Arg Asp Ile Val 325 330 335 Ala Arg Thr Gly Gly Ala Met Thr Gly Thr Ala Thr Leu Arg Lys Ala 340 345 350 Page 277 of 3790 Leu Gly Glu Ala Leu Trp Thr Asp Met Gin Glu Arg Pro Glu Gin Leu 355 360 365 Asp Ala Ile Val Gin Val Leu Ser Phe Phe Glu Ala Asn Glu Thr Ile 370 375 380 Thr Glu Lys Leu Arg Glu Ile Gly Leu Thr Leu Ala Val Leu Asp Val 385 390 395 400 Leu Leu Thr Ala Leu Asp Ala Gly Val Phe Ala Lys Phe Lys Gly Ala 405 410 415 Ala His Ile Ser Thr Lys Ala Ala Arg Asn Leu Leu Pro His Leu Glu 420 425 430 Gin Gly Arg Arg Tyr Asp Glu Ala Cys Thr Met Ala Gly Tyr Asp His 435 440 445 Ala Ala Ser Arg Leu Ser His His Gly Gin Ile Val Ala Lys Thr Gin 450 455 460 Phe Asn Ala Leu Val Thr Glu Ile Gly Glu Ser Ile Ala Asn Pro Ile 465 470 475 480 Ala Arg Lys Ala Leu Ile Glu Gly Leu Lys Gin Ile Trp Ala Met Arg 485 490 495 Asn His Trp Gly Leu Pro Gly Ser Ile His Val Glu Leu Ala Arg Asp 500 505 510 Val Gly Asn Ser Ile Glu Lys Arg Arg Glu Ile Glu Lys His Ile Glu 515 520 525 Lys Asn Thr Ala Leu Arg Ala Arg Glu Arg Arg Glu Val His Asp Leu 530 535 540 Leu Asp Leu Glu Asp Val Asn Gly Asp Thr Leu Leu Arg Tyr Arg Leu 545 550 555 560 Trp Lys Glu Gin Gly Gly Lys Cys Leu Tyr Thr Gly Lys Ala Ile His 565 570 575 Ile Arg Gin Ile Ala Ala Thr Asp Asn Ser Val Gin Val Asp His Ile 580 585 590 Leu Pro Trp Ser Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu 595 600 605 Page 278 of 3790 Cys Leu Ala Ser Ala Asn Gin Gin Lys Lys Arg Ser Thr Pro Tyr Glu 610 615 620 Trp Leu Ser Gly Gin Thr Gly Asp Ala Trp Asn Ala Phe Val Gin Arg 625 630 635 640 Ile Glu Thr Asn Lys Glu Leu Arg Gly Phe Lys Lys Arg Asn Tyr Leu 645 650 655 Leu Lys Asn Ala Lys Glu Ala Glu Glu Lys Phe Arg Ser Arg Asn Leu 660 665 670 Asn Asp Thr Arg Tyr Ala Ala Arg Leu Phe Ala Glu Ala Val Lys Leu 675 680 685 Leu Tyr Ala Phe Gly Glu Arg Gin Glu Lys Gly Gly Asn Arg Arg Val 690 695 700 Phe Thr Arg Pro Gly Ala Leu Thr Ala Ala Leu Arg Gin Ala Trp Gly 705 710 715 720 Val Glu Ser Leu Lys Lys Gin Asp Gly Lys Arg Ile Asn Asp Asp Arg 725 730 735 His His Ala Leu Asp Ala Leu Thr Val Ala Ala Val Asp Glu Ala Glu 740 745 750 Ile Gin Arg Leu Thr Lys Ser Phe His Glu Trp Glu Gin Gin Gly Leu 755 760 765 Gly Arg Pro Leu Arg Arg Val Glu Pro Pro Trp Glu Ser Phe Arg Ala 770 775 780 Asp Val Glu Ala Thr Tyr Pro Glu Val Phe Val Ala Arg Pro Glu Arg 785 790 795 800 Arg Arg Ala Arg Gly Glu Gly His Ala Ala Thr Ile Arg Gin Val Lys 805 810 815 Glu Arg Glu Cys Thr Pro Ile Val Phe Glu Arg Lys Ala Val Ser Ser 820 825 830 Leu Lys Glu Ala Asp Leu Glu Arg Ile Lys Asp Gly Glu Arg Asn Glu 835 840 845 Ala Ile Val Glu Ala Ile Arg Ser Trp Ile Ala Thr Gly Arg Pro Ala 850 855 Page 279 of 3790 860 59 1391 PRT Kordia algicida 59 Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Asn Glu Ala Glu His Glu His Glu Gin Ser Ser Ile Val Page 281 of 3790 Val Leu Val Glu Ile Asn Asn Asn Ile Asn Lys Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Ala Leu Tyr Phe Asn Asn Glu Thr 290 295 300 Val Gly Glu Tyr Leu Tyr Gly Gin Leu Val Lys Asn Arg His Asn Ser 305 310 315 320 Leu Arg Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Lys Ile Trp Glu Thr Gin Ala Lys Phe Tyr Asp Glu Leu Thr Asn Glu 340 345 350 Leu Lys Gin Glu Ile Arg Asp Val Val Ile Phe Tyr Gin Arg Lys Leu 355 360 365 Lys Ser Gin Lys His Leu Ile Ser Asp Cys Leu Phe Glu Lys His His 370 375 380 Lys Ala Ile Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys Ile Trp 385 390 395 400 Gin Asn Leu Asn Tyr Leu Glu Phe Val His Thr Gin Ser Lys Glu Lys 405 410 415 Ile Phe Phe Ser Glu Leu Asp Asp Glu Thr Arg Gin Phe Val Phe Ala 420 425 430 Glu Leu Asn Ile Arg Gly Thr Leu Lys Ile Lys Glu Ile Lys Lys Leu 435 440 445 Ile Gly Leu Glu Thr Pro Val Tyr Trp Lys Ser Asn Phe Asp Glu Ile 450 455 460 Glu Gly Asn Arg Thr Asn Gin Val Leu Tyr Asn Val Tyr Gin Asn Ile 465 470 475 480 Ala Asp Asp Leu Gly Tyr Gly Phe Asp Trp Ser Lys Lys His Ala Phe 485 490 495 Glu Ile Asn Ala Glu Leu Gin Ala Ile Phe Lys Asp Val Gly Ile Asp 500 505 510 Thr Ala Ile Leu Asn Phe Asp Ala Ser Ile Glu Glu Asn Asp Phe Asp 515 520 525 Page 282 of 3790 Lys Gin Lys Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser Ala Glu Asp 530 535 540 Thr Asp Lys Ala Thr Glu Glu Asp Lys Leu Ile Tyr Gly Asn Ile Asn 545 550 555 560 Thr Lys Leu Lys Lys Gin Leu His Gin Lys Tyr Gly Phe Glu Ala Lys 565 570 575 Tyr Gly Asn Leu Leu Ala Asn Ile Ser Leu Gin Gin Asp Tyr Gly Asn 580 585 590 Leu Ser Ala Lys Ala Ile Lys Lys Ile Leu Pro Tyr Leu Glu Ser Gly 595 600 605 Asn Ser Phe Tyr Glu Ala Cys Thr Ile Val Gly Tyr Asn Pro Ser Asn 610 615 620 Ser Leu Thr Lys Glu Gin Gin Gin Asn Arg Lys Leu Lys Asp Lys Leu 625 630 635 640 Glu Leu Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile 645 650 655 Leu Asn Gin Lys Val Asn Leu Ile Asn Gin Leu Ile Asp Glu Tyr Gly 660 665 670 Lys Pro Asp Glu Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser 675 680 685 Ala Lys Gin Arg Ala Asp Leu Ser Lys His Ile Asn Asp Ala Thr Leu 690 695 700 Lys Asn Gin Asn Ile Arg Lys Thr Leu Gin Lys Asp Phe Gly Ile Gin 705 710 715 720 Asn Pro Ser Lys Asn Asp Val Ile Arg Tyr Lys Leu Tyr Asp Glu Leu 725 730 735 Lys Asp Asn Gly Tyr Lys Thr Leu Phe Thr Asn Lys Tyr Ile Pro Lys 740 745 750 Glu Gin Leu Phe Ser Lys Asp Val Asp Ile Glu His Ile Ile Pro Lys 755 760 765 Ala Ile Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Tyr Arg 770 775 780 Page 283 of 3790 Arg Thr Lys Thr Lys Thr Lys Gly Val Phe Asn Glu Lys Ile Gin Page 285 of 3790 60 1116 PRT Clostridium spiroforme 60 Met Val Glu Phe Leu Leu Lys Glu Met Lys Ile Met Gly Arg Leu Val 15 10 15 Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Tyr Gly Val Ile Asp 20 25 30 Ile Asp Lys Asn Glu Phe Val Asp Tyr Gly Val Arg Leu Phe Lys Glu 35 40 45 Gly Thr Ala Ile Asn Asn Glu Glu Arg Arg Ser Lys Arg Gly Ala Arg 50 55 60 Arg Leu Lys Arg Arg Lys Thr Asn Arg Ile Ala Asp Met Lys Lys Leu 65 70 75 80 Page 286 of 3790 Leu Glu Arg Asn Gly Leu Ile Asp Glu Gin Tyr Thr Ala Leu Asn Asn 85 90 95 Pro Tyr Glu Ile Arg Lys Lys Gly Leu Lys Asn Lys Leu Ser Asn Tyr 100 105 110 Glu Leu Ala Thr Ala Ile Leu His Ile Thr Lys Asn Arg Gly Thr Cys 115 120 125 Leu Glu Ser Asn Ala Asp Glu Thr Gin Asp Glu Glu Ser Thr Lys Asn 130 135 140 Ile Leu Ser Lys Asn Ala Leu Glu Leu Lys Asp Lys Tyr Ile Cys Glu 145 150 155 160 Ile Gin Leu Ala Arg Leu Glu Glu Ser Gly Lys Ile Arg Gly Ile Asn 165 170 175 Asn Asn Phe Lys Thr Glu Asp Tyr Leu Lys Glu Leu Ser Lys Ile Leu 180 185 190 Glu Asn Gin Asp Leu Glu Lys Glu Thr Ile Asp Lys Ile Lys Glu Ile 195 200 205 Val Ala Arg Arg Arg Arg Tyr Asp Gin Gly Pro Gly Ser Glu Lys Ser 210 215 220 Pro Thr Pro Tyr Gly Ser Tyr Arg Met Glu Asn Gly Glu Leu Val His 225 230 235 240 Val Asn Leu Ile Asp Met Met Arg Gly Lys Cys Ser Val Phe Pro Asp 245 250 255 Gin Leu Arg Ala Pro Gin Gin Ser Tyr Ser Ala Glu Leu Phe Asn Leu 260 265 270 Leu Asn Asp Leu Asn Asn Leu Lys Ile Asn Gly Glu Lys Leu Ser Ser 275 280 285 Thr Glu Lys Gin Lys Ile Ile Asp Phe Val Asn Glu Lys Gly Gly Ile 290 295 300 Thr Val Lys Gin Leu Leu Lys Leu Ile Asp Val Gly Ile Thr Glu Ile 305 310 315 320 Ser Gly Phe Arg Ile Asp Lys Asn Glu Lys Pro Leu Ile Thr Glu Phe 325 330 335 Page 287 of 3790 Lys Gly Tyr Lys Lys Val Leu Lys Val Phe Lys Asn Tyr Asn Gin Glu 340 345 350 Ser Leu Leu Asn Asp Lys Ser Ile Val Asp Thr Ile Met Asp Ile Asn 355 360 365 Thr Lys Ile Lys Ser Ile Asp Glu Arg Ser Asp Gin Leu Lys Gin Val 370 375 380 Leu Pro Ser Leu Asp Thr Ser Ile Ile Asn Asp Leu Ala Ser Ile Lys 385 390 395 400 Gly Val Ser Gly Tyr His Ser Leu Ser Leu Lys Ala Leu Asn Leu Ile 405 410 415 Asn Asn Glu Met Leu Lys Thr Glu Met Asn Gin Met Gin Val Leu His 420 425 430 Gin Leu Asp Ile Phe Asp Lys Asn Arg Val Ser Leu Lys Gly Gin Arg 435 440 445 Gin Ile Tyr Ala Asp Asp Asn Ala Ile Leu Ser Pro Val Ala Lys Arg 450 455 460 Ala His Arg Glu Thr Phe Lys Val Ile Asn Lys Leu Arg Ser Ile Tyr 465 470 475 480 Gly Glu Phe Asp Ser Ile Val Ile Glu Thr Thr Arg Asp Lys Asn Thr 485 490 495 Gin Asp Gin Lys Lys Arg Ile Lys Asn Asn Gin Lys Asn Tyr Glu Glu 500 505 510 Arg Asn Thr Glu Val Asn Asn Phe Leu Lys Glu Ala Gly Tyr Asn Pro 515 520 525 Glu Asn Ile Asn Ala Lys Thr Lys Met Lys Ile Arg Leu Tyr Ile Glu 530 535 540 Gin Asp Ala Lys Ser Ala Tyr Thr Leu Gin Asp Ile Asn Leu Lys Glu 545 550 555 560 Leu Ile Glu Asp Glu Lys Ala Tyr Glu Ile Asp His Ile Ile Pro Ile 565 570 575 Ser Ile Ser Leu Asp Asp Ser Phe Asn Asn Lys Val Leu Thr Thr His 580 585 590 Page 288 of 3790 Asp Glu Asn Gin Glu Lys Gly Asn Leu Thr Pro Ile Ser Ala Phe Leu 595 600 605 Lys Gly Lys Phe His Asn Gly Asn Leu Asn Thr Tyr Lys Val Phe Ile 610 615 620 Gin Asn Asn Lys Asn Leu Asn Arg Lys Lys Lys Glu Tyr Leu Leu Cys 625 630 635 640 Glu Asp Asp Ile Thr Arg Tyr Glu Val Val Gin Asn Phe Ile Asn Arg 645 650 655 Asn Leu Val Asp Thr Ser Tyr Ala Cys Arg Thr Val Met Asn Thr Leu 660 665 670 Val His Tyr Phe Lys Asp Asn Glu Ile Asn Thr Lys Val His Thr Ile 675 680 685 Lys Gly Gin Ala Thr Ser Thr Phe Arg Lys Arg Ile Gly Leu Ile Lys 690 695 700 Asp Arg Glu Glu Asp Tyr Phe His His Ala Ile Asp Ala Leu Ile Val 705 710 715 720 Ala Ser Leu Lys Lys Met Asn Leu Ile Asn Ser Tyr Leu Met Lys Val 725 730 735 Asp Phe Asn Glu Met Tyr Asp Glu Glu Thr Gly Glu Ile Phe Asn Val 740 745 750 Leu Pro Asp Asn Ser Tyr Leu Asp Glu Lys Tyr Ile Ser Phe Val Ser 755 760 765 Asn Leu Lys Asn Ile Tyr Glu Glu Ser Asn Lys Tyr Ile Arg Gly Val 770 775 780 Met Ile Lys Glu Lys Met Thr Tyr Pro Leu Ile Lys Val Ser His Lys 785 790 795 800 Ile Asp Thr Lys Pro Asn Arg Lys Ile Ser Asp Asp Thr Ile Tyr Ser 805 810 815 Thr Arg Asn Val 820 Asp Asn Gin Asp Met 825 Leu Val Glu Arg Ile Lys Asn 830 Ile Tyr Asp Pro Lys Glu Asn Ala Ala Asn Thr Leu Ile Asn Asp Ile Page 289 of 3790 Page 290 of 3790 61 1348 PRT Finegoldia magna 61 Page 291 of 3790 Glu Gin Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 180 185 190 Glu Glu Leu Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 195 200 205 Lys Arg Thr Asp Lys Lys Asn Asn Leu Lys Glu Leu Ile Lys Gly Gin 210 215 220 Asp Phe Asn Lys Gin Glu Gly Asn Ile Leu Asn Ser Ile Phe Glu Ser 225 230 235 240 Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 245 250 255 Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 260 265 270 Gly Asp Ser Tyr Glu Glu Asn Leu Gin Tyr Phe Glu Glu Val Leu Gin 275 280 285 Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Thr Tyr Asp Phe Leu 290 295 300 Ile Leu Gin Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gin 305 310 315 320 Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 325 330 335 Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gin Val Phe 340 345 350 Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 355 360 365 Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 370 375 380 Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gin Cys Asp Cys Glu 385 390 395 400 Asp Glu Asp Val Lys Tyr Leu Leu Gly Lys Ile Glu Gin Glu Asn Phe 405 410 415 Leu Leu Lys Gin Ile Ser Ser Ile Asn Ser Val Ile Pro His Gin Ile 420 425 430 Page 292 of 3790 His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Asn Tyr 435 440 445 Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 450 455 460 Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 465 470 475 480 Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 485 490 495 Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 500 505 510 Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gin Cys Thr Tyr 515 520 525 Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 530 535 540 Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Gly Lys Pro 545 550 555 560 Leu Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 565 570 575 Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Val Arg Asn 580 585 590 Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 595 600 605 Ile Ala Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Glu 610 615 620 Asp Lys Phe Asp Val Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 625 630 635 640 Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 645 650 655 Tyr Pro Asp Leu Ser Ser Ser Gin Ile Gin Lys Ile Ile Asn Leu Lys 660 665 670 Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Lys 675 680 685 Page 293 of 3790 Gly Thr Lys Lys Glu Thr Glu Lys Thr Asp Thr Val Ile Asn Phe Leu 690 695 700 Arg Asn Ser Ser Asp Asn Leu Met Gin Ile Ile Gly Ser Gin Asn Tyr 705 710 715 720 Ser Phe Asn Glu Tyr Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gin 725 730 735 Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 740 745 750 Lys Lys Met Ile Trp Gin Val Ile Arg Val Thr Glu Glu Ile Thr Lys 755 760 765 Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 770 775 780 Glu Glu Glu Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Asp 785 790 795 800 Leu Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gin Tyr Glu Lys 805 810 815 Leu Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg 820 825 830 Lys Leu Tyr Leu Tyr Tyr Thr Gin Met Gly Arg Asp Met Tyr Thr Gly 835 840 845 Glu Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys 850 855 860 Asp His Ile Ile Pro Gin Ser Met Lys Lys Asp Asp Ser Ile Ile Asn 865 870 875 880 Asn Leu Val Leu Val Asn Lys Asn Ala Asn Gin Thr Thr Lys Gly Asn 885 890 895 Ile Tyr Pro Val Pro Ser Ser Ile Arg Asn Asn Pro Lys Ile Tyr Asn 900 905 910 Tyr Trp Lys Tyr Leu Met Glu Lys Glu Phe Ile Ser Lys Glu Lys Tyr 915 920 925 Asn Arg Leu Ile Arg Asn Thr Pro Leu Thr Asn Glu Glu Leu Gly Gly 930 935 Page 294 of 3790 940 62 1129 PRT Streptococcus infantarius 62 Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Val Ala Ser Val 15 10 15 Gly Val Gly Ile Ile Asp Ser Lys Thr Gly Asn Val Ile His Ala Asn 20 25 30 Page 297 of 3790 Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gin Lys Glu Tyr Leu Val 290 295 300 Asp Phe Ala Lys Lys Ser Lys Ala Leu Gly Ala Ser Lys Leu Leu Lys 305 310 315 320 Glu Ile Ala Lys Ile Val Asp Cys Ser Val Asp Asp Ile Lys Gly Tyr 325 330 335 Arg Val Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 340 345 350 Arg Lys Leu Lys Phe Asn Leu Ser Ser Ile Asp Ile Asp Glu Leu Ser 355 360 365 Arg Glu Thr Leu Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Ser Gin Phe 385 390 395 400 Thr Glu Glu Gin Ile Ser Glu Ile Val Gin Ile Arg Lys Asn Gin Ser 405 410 415 Ser Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Val Thr Ser Glu Glu Gin Met Thr Ile 435 440 445 Leu Thr Arg Leu Glu Lys Phe Lys Val Asn Lys Lys Ser Ser Lys Asn 450 455 460 Thr Lys Thr Ile Asp Glu Lys Glu Ile Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Val Arg Gin Thr Ile Lys Ile Ile Asn Ala Ala 485 490 495 Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 500 505 510 Asp Lys Asn Ala Glu Asp Glu Lys Lys Phe Ile Asp Lys Lys Gin Lys 515 520 525 Glu Asn Lys Lys Glu Lys Asp Asp Ser Leu Lys Arg Ala Ala Phe Leu 530 535 540 Page 298 of 3790 Tyr Asn Gly Thr Asp Asn Leu Pro Asp Gly Val Phe His Gly Asn Lys 545 550 555 560 Glu Leu Lys Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Ser Gly Lys Leu Ile Ser Ile His Asp Leu Val His Asn Ser 580 585 590 Asn Lys Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Trp Thr Asn Gin Glu 610 615 620 Lys Gly Gin Lys Thr Pro Tyr Gin Val Ile Asp Ser Met Asp Thr Ala 625 630 635 640 Trp Ser Phe Arg Glu Met Lys Asp Tyr Val Leu Lys Gin Lys Gly Leu 645 650 655 Gly Lys Lys Lys Cys Glu Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 660 665 670 Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gin Thr Ala Leu Lys Glu 690 695 700 Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg Lys Trp Asn Ile Asp Lys Ser Arg Glu Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Lys 740 745 750 Leu Trp Gin Lys Gin Glu Asn Pro Met Phe Glu Ser Tyr Gly Glu Asn 755 760 765 Gin Val Val Asn Lys Glu Thr Gly Glu Ile Leu Ser Ile Ser Asp Asp 770 775 780 Lys Tyr Lys Glu Leu Val Phe Gin Pro Pro Tyr Gin Gly Phe Val Asn Asp Ala Ile Arg Glu Lys Glu Gly Ile Gly Lys Lys Ser Glu Phe 1010 1015 1020 Lys Phe Thr Leu Tyr Arg Asn Asp Leu Ile Leu Ile Lys Asp Thr 1025 1030 1035 Page 300 of 3790 Lys 63 1065 PRT Clostridium perfringens 63 Met Asn Lys Asp Ile Asn Tyr Ala Leu Gly Leu Asp Ile Gly Ile Thr 15 10 15 Ser Val Gly Trp Ala Val Ile Asn Leu Asp Leu Asn Arg Ile Glu Asp 20 25 30 Leu Gly Val Arg Ile Phe Asn Ala Ala Glu Asn Leu Lys Asp Gly Ser 35 40 45 Ser Leu Ala Leu Pro Arg Arg Leu Ala Arg Gly Arg Arg Arg Leu Leu 50 55 60 Arg Arg Lys Ala Tyr Arg Val Glu Arg Val Arg Lys Leu Ile Leu Lys 65 70 75 80 Asn Asn Ile Leu Thr Lys Glu Glu Leu Glu Gly Leu Phe Lys Asn Lys 85 90 95 Glu Val Ile Asp Val Trp Glu Ala Arg Val Lys Gly Leu Asp Tyr Lys 100 105 110 Page 301 of 3790 Leu Ser Arg Glu Glu Trp Ala Lys Ile Leu Ile Asn Phe Cys Lys Arg 115 120 125 Arg Gly Phe Lys Ser Asn Arg Lys Asn Glu Ala Lys Asp Lys Glu Ala 130 135 140 Gly Gin Ile Leu Ser Ser Ile Ser Tyr Asn Ile Glu Lys Met Lys Glu 145 150 155 160 Thr Asn Ser Arg Thr Ile Gly Glu Tyr Ile Tyr Asn Glu Val Lys Asn 165 170 175 Ser Glu Asp Ser Tyr Ala Pro Leu Arg Asn Lys Phe Gly Glu Tyr Lys 180 185 190 Met Cys Val Ser Arg Asp Val Ile Arg Glu Glu Ile His Thr Leu Phe 195 200 205 Glu Lys Gin Arg Glu Leu Gly Asn Asn Phe Ala Ser Asp Glu Ile Glu 210 215 220 Asp Lys Tyr Phe Glu Ile Phe Asn Ser Gin Arg Pro Phe Ser Asn Phe 225 230 235 240 Glu Asp Leu Glu Lys Leu Val Gly Phe Cys Thr Phe Glu Arg Lys Lys 245 250 255 His Lys Arg Ala Pro Lys His Cys Ile Ser Ser Glu Glu Phe Thr Leu 260 265 270 Tyr Glu Gly Ile Asn Lys Leu Ser Ile Ile Lys Asp Gly Glu Lys Arg 275 280 285 Lys Leu Ser Glu Glu Glu Arg Thr Leu Val Val Asn Glu Ala Phe Asn 290 295 300 Lys Lys Glu Ile Lys Tyr Thr Thr Leu Arg Lys Leu Leu Gly Leu Ser 305 310 315 320 Glu Glu Glu Leu Phe Ser Thr Leu Thr Tyr Ser Ile Asp Lys Asp Ile 325 330 335 Ser Lys Thr Glu Asn Thr Lys Phe Val Ser Leu Lys Gly Tyr His Glu 340 345 350 Ile Lys Arg Ala Ile Glu Lys Gly Val Ser Lys Lys Ala Trp Gin Asp 355 360 365 Page 302 of 3790 Ile Glu Asn Asn Arg Asn Leu Leu Asn Asp Ile Ala Tyr Val Leu Thr 370 375 380 Leu Gly Lys Thr Asp Asp Glu Ile Glu Lys Gin Leu Arg Leu Arg Asn 385 390 395 400 Val Pro Glu Glu Leu Phe Glu Ser Leu Leu Asp Met Ser Phe Asn Lys 405 410 415 Phe Asn Asn Leu Ser Ile Tyr Ala Leu Glu Lys Ile Leu Pro Phe Met 420 425 430 Lys Glu Gly Tyr Gin Tyr Asn Glu Ala Cys Glu Lys Ala Gly Tyr Asn 435 440 445 Phe Lys Ala Ile Tyr Glu Gly Val Arg Thr Lys Lys Leu Pro Val Ile 450 455 460 Glu Ile Asp Glu Ile Val Asn Pro Val Val Asn Arg Ala Leu Ala Gin 465 470 475 480 Thr Arg Lys Val Ile Asn Ser Val Ile Asp Lys Tyr Gly Ser Pro Val 485 490 495 Arg Ile Asn Ile Glu Leu Ala Arg Asp Leu Ala Lys Asn Phe Lys Asp 500 505 510 Arg Lys Leu Ile Glu Lys Glu Gin Lys Glu Asn Arg Ala Asn Leu Asp 515 520 525 Lys Ile Arg Glu Asn Leu Arg Glu Leu Met Asp Lys Glu Pro Thr Val 530 535 540 Val Glu Val Leu Lys Tyr Arg Leu Trp Glu Gin Gin Arg Gly Glu Cys 545 550 555 560 Ala Tyr Thr Gin Ser Gin Ile Pro Leu Glu Arg Leu Phe Ser Pro Gly 565 570 575 Tyr Cys Glu Ile Asp His Ile Ile Pro Phe Ser Arg Ser Phe Asp Asp 580 585 590 Ser Leu Ser Asn Lys Ile Leu Val Leu Gly Ser Glu Asn Gin Arg Lys 595 600 605 Gly Asn Arg Thr Pro Tyr Glu Tyr Phe Gly Glu Asp Ser Glu Arg Trp 610 615 620 Page 303 of 3790 Asn Ser Phe Glu Ile Trp Val Lys Gly Ser Tyr Leu Asn Tyr Lys Lys 625 630 635 640 Lys Ala Asn Leu Leu Lys Lys Lys Phe Ser Glu Glu Glu Gin Arg Asp 645 650 655 Trp Lys Ala Arg Asn Leu Gin Asp Thr Lys Tyr Ile Cys Arg Tyr Ile 660 665 670 Ser Asn Phe Val Asn Asn Arg Leu Glu Phe Lys Glu Ser Glu Asn Lys 675 680 685 Gin Lys Val Ile Thr Val Asn Gly Arg Ala Thr Ala Tyr Leu Arg Ser 690 695 700 Arg Trp Gly Leu Asn Lys Val Arg Glu Asp Gly Asp Lys His His Ala 705 710 715 720 Leu Asp Ala Ala Val Val Gly Val Thr Thr Gin Gly Met Val Gin Lys 725 730 735 Ile Ser Lys Tyr Ser Lys Ala His Glu Leu Tyr Thr Val Arg Lys Asn 740 745 750 Asp Glu Phe Val Asp Val Glu Thr Gly Glu Cys Val Asp Val Asp Glu 755 760 765 Tyr Lys Glu Ile Arg Lys Asp Ile Leu Pro Arg Pro Trp Arg Gly Phe 770 775 780 Ser Glu Glu Leu Lys Leu Arg Leu Ser Asp Asn Pro Leu Glu Glu Leu 785 790 795 800 Lys Lys Ser Pro Ile Glu Thr Tyr Asn Glu Glu Phe Ile Lys Glu Asn 805 810 815 Val Lys Pro Ile Phe Val Ser Arg Val Pro Phe Arg Lys Ile Ser Gly 820 825 830 Lys Leu Phe Lys Glu Thr Ile Tyr Ser Glu Arg Ala Phe Lys Asp Gly 835 840 845 Tyr Phe Val Ser Lys Lys Ser Leu Val Asp Leu Lys Arg Gly Asp Leu 850 855 860 Asp Asn Phe Tyr Asn Tyr Glu Cys Asp Lys Lys Leu Tyr Asp Ala Ile 64 1195 PRT Elusimicrobium minutum 64 Met Gin Lys Asn Ile Asn Thr Lys Gin Asn His Ile Tyr Ile Lys Gin 15 10 15 Ala Gin Lys Ile Lys Glu Lys Leu Gly Asp Lys Pro Tyr Arg Ile Gly 500 505 510 Gin Lys Ile Ile Ala Lys Gly Phe Ser Pro Gin Phe Lys Asp Lys Gly 515 520 525 Page 307 of 3790 Tyr Lys Thr Pro His Thr Asn Lys Tyr Glu Leu Glu Tyr Gly Arg Ile 530 535 540 Ala Asn Pro Val Val His Gin Thr Leu Asn Glu Leu Arg Lys Leu Val 545 550 555 560 Asn Glu Ile Ile Asp Ile Leu Gly Lys Lys Pro Cys Glu Ile Gly Leu 565 570 575 Glu Thr Ala Arg Glu Leu Lys Lys Ser Ala Glu Asp Arg Ser Lys Leu 580 585 590 Ser Arg Glu Gin Asn Asp Asn Glu Ser Asn Arg Asn Arg Ile Tyr Glu 595 600 605 Ile Tyr Ile Arg Pro Gin Gin Gin Val Ile Ile Thr Arg Arg Glu Asn 610 615 620 Pro Arg Asn Tyr Ile Leu Lys Phe Glu Leu Leu Glu Glu Gin Lys Ser 625 630 635 640 Gin Cys Pro Phe Cys Gly Gly Gin Ile Ser Pro Asn Asp Ile Ile Asn 645 650 655 Asn Gin Ala Asp Ile Glu His Leu Phe Pro Ile Ala Glu Ser Glu Asp 660 665 670 Asn Gly Arg Asn Asn Leu Val Ile Ser His Ser Ala Cys Asn Ala Asp 675 680 685 Lys Ala Lys Arg Ser Pro Trp Ala Ala Phe Ala Ser Ala Ala Lys Asp 690 695 700 Ser Lys Tyr Asp Tyr Asn Arg Ile Leu Ser Asn Val Lys Glu Asn Ile 705 710 715 720 Pro His Lys Ala Trp Arg Phe Asn Gin Gly Ala Phe Glu Lys Phe Ile 725 730 735 Glu Asn Lys Pro Met Ala Ala Arg Phe Lys Thr Asp Asn Ser Tyr Ile 740 745 750 Ser Lys Val Ala His Lys Tyr Leu Ala Cys Leu Phe Glu Lys Pro Asn 755 760 765 Ile Ile Cys Val Lys Gly Ser Leu Thr Ala Gin Leu Arg Met Ala Trp 770 775 780 Page 308 of 3790 Lys Tyr Val Gin Leu Ser Lys Lys Glu Pro Gly Lys Phe Phe Ala 1190 1195 65 1101 PRT Akkermansia muciniphila 65 Met Ser Arg Ser Leu Thr Phe Ser Phe Asp Ile Gly Tyr Ala Ser Ile 15 10 15 Gly Trp Ala Val Ile Ala Ser Ala Ser His Asp Asp Ala Asp Pro Ser 20 25 30 Val Cys Gly Cys Gly Thr Val Leu Phe Pro Lys Asp Asp Cys Gin Ala Page 310 of 3790 40 45 Phe Lys Arg Arg Glu Tyr Arg Arg Leu Arg Arg Asn Ile Arg Ser Arg 50 55 60 Arg Val Arg Ile Glu Arg Ile Gly Arg Leu Leu Val Gin Ala Gin Ile 65 70 75 80 Ile Thr Pro Glu Met Lys Glu Thr Ser Gly His Pro Ala Pro Phe Tyr 85 90 95 Leu Ala Ser Glu Ala Leu Lys Gly His Arg Thr Leu Ala Pro Ile Glu 100 105 110 Leu Trp His Val Leu Arg Trp Tyr Ala His Asn Arg Gly Tyr Asp Asn 115 120 125 Asn Ala Ser Trp Ser Asn Ser Leu Ser Glu Asp Gly Gly Asn Gly Glu 130 135 140 Asp Thr Glu Arg Val Lys His Ala Gin Asp Leu Met Asp Lys His Gly 145 150 155 160 Thr Ala Thr Met Ala Glu Thr Ile Cys Arg Glu Leu Lys Leu Glu Glu 165 170 175 Gly Lys Ala Asp Ala Pro Met Glu Val Ser Thr Pro Ala Tyr Lys Asn 180 185 190 Leu Asn Thr Ala Phe Pro Arg Leu Ile Val Glu Lys Glu Val Arg Arg 195 200 205 Ile Leu Glu Leu Ser Ala Pro Leu Ile Pro Gly Leu Thr Ala Glu Ile 210 215 220 Ile Glu Leu Ile Ala Gin His His Pro Leu Thr Thr Glu Gin Arg Gly 225 230 235 240 Val Leu Leu Gin His Gly Ile Lys Leu Ala Arg Arg Tyr Arg Gly Ser 245 250 255 Leu Leu Phe Gly Gin Leu Ile Pro Arg Phe Asp Asn Arg Ile Ile Ser 260 265 270 Arg Cys Pro Val Thr Trp Ala Gin Val Tyr Glu Ala Glu Leu Lys Lys 275 280 285 Page 311 of 3790 Gly Asn Ser Glu Gin Ser Ala Arg Glu Arg Ala Glu Lys Leu Ser Lys 290 295 300 Val Pro Thr Ala Asn Cys Pro Glu Phe Tyr Glu Tyr Arg Met Ala Arg 305 310 315 320 Ile Leu Cys Asn Ile Arg Ala Asp Gly Glu Pro Leu Ser Ala Glu Ile 325 330 335 Arg Arg Glu Leu Met Asn Gin Ala Arg Gin Glu Gly Lys Leu Thr Lys 340 345 350 Ala Ser Leu Glu Lys Ala Ile Ser Ser Arg Leu Gly Lys Glu Thr Glu 355 360 365 Thr Asn Val Ser Asn Tyr Phe Thr Leu His Pro Asp Ser Glu Glu Ala 370 375 380 Leu Tyr Leu Asn Pro Ala Val Glu Val Leu Gin Arg Ser Gly Ile Gly 385 390 395 400 Gin Ile Leu Ser Pro Ser Val Tyr Arg Ile Ala Ala Asn Arg Leu Arg 405 410 415 Arg Gly Lys Ser Val Thr Pro Asn Tyr Leu Leu Asn Leu Leu Lys Ser 420 425 430 Arg Gly Glu Ser Gly Glu Ala Leu Glu Lys Lys Ile Glu Lys Glu Ser 435 440 445 Lys Lys Lys Glu Ala Asp Tyr Ala Asp Thr Pro Leu Lys Pro Lys Tyr 450 455 460 Ala Thr Gly Arg Ala Pro Tyr Ala Arg Thr Val Leu Lys Lys Val Val 465 470 475 480 Glu Glu Ile Leu Asp Gly Glu Asp Pro Thr Arg Pro Ala Arg Gly Glu 485 490 495 Ala His Pro Asp Gly Glu Leu Lys Ala His Asp Gly Cys Leu Tyr Cys 500 505 510 Leu Leu Asp Thr Asp 515 Ser Ser Val Asn 520 Gin His Gin Lys 525 Glu Arg Arg Leu Asp Thr Met Thr Asn Asn His Leu Val Arg His Arg Met Leu Ile 530 535 540 Page 312 of 3790 Leu Asp Arg Leu Leu Lys Asp Leu Ile Gin Asp Phe Ala Asp Gly Gin 545 550 555 560 Lys Asp Arg Ile Ser Arg Val Cys Val Glu Val Gly Lys Glu Leu Thr 565 570 575 Thr Phe Ser Ala Met Asp Ser Lys Lys Ile Gin Arg Glu Leu Thr Leu 580 585 590 Arg Gin Lys Ser His Thr Asp Ala Val Asn Arg Leu Lys Arg Lys Leu 595 600 605 Pro Gly Lys Ala Leu Ser Ala Asn Leu Ile Arg Lys Cys Arg Ile Ala 610 615 620 Met Asp Met Asn Trp Thr Cys Pro Phe Thr Gly Ala Thr Tyr Gly Asp 625 630 635 640 His Glu Leu Glu Asn Leu Glu Leu Glu His Ile Val Pro His Ser Phe 645 650 655 Arg Gin Ser Asn Ala Leu Ser Ser Leu Val Leu Thr Trp Pro Gly Val 660 665 670 Asn Arg Met Lys Gly Gin Arg Thr Gly Tyr Asp Phe Val Glu Gin Glu 675 680 685 Gin Glu Asn Pro Val Pro Asp Lys Pro Asn Leu His Ile Cys Ser Leu 690 695 700 Asn Asn Tyr Arg Glu Leu Val Glu Lys Leu Asp Asp Lys Lys Gly His 705 710 715 720 Glu Asp Asp Arg Arg Arg Lys Lys Lys Arg Lys Ala Leu Leu Met Val 725 730 735 Arg Gly Leu Ser His Lys His Gin Ser Gin Asn His Glu Ala Met Lys 740 745 750 Glu Ile Gly Met Thr Glu Gly Met Met Thr Gin Ser Ser His Leu Met 755 760 765 Lys Leu Ala Cys Lys Ser Ile Lys Thr Ser Leu Pro Asp Ala His Ile 770 775 780 Asp Met Ile Pro Gly Ala Val Thr Ala Glu Val Arg Lys Ala Trp Asp 785 790 795 800 Page 313 of 3790 Ala Gly Val Trp Arg Ile Glu Ser Ile Gin Asp Ser Lys Gly Gly Page 314 of 3790 1040 1045 1050 Glu Leu Ala Thr Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Page 316 of 3790 Val Gin Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val 405 410 415 Ala Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg 420 425 430 Leu Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala 435 440 445 Tyr Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu 450 455 460 Thr Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser 465 470 475 480 Val Glu Thr Leu Gin Lys Leu Thr Arg Gin Met Leu Thr Thr Asp Asp 485 490 495 Asp Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp 500 505 510 Arg Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val 515 520 525 Asp Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gin Gin 530 535 540 Arg Trp Gly Asn Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser 545 550 555 560 Phe Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys 565 570 575 Asn Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gin Leu 580 585 590 Arg Ala Asp Glu Gin Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg 595 600 605 Leu Glu Ala Ile Gin Arg Gin Asn Gly Gin Cys Leu Tyr Cys Gly Arg 610 615 620 Thr Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys 625 630 635 640 Gly Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala 645 650 655 Page 317 of 3790 Glu Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg 660 665 670 Ser Glu Asp Ala Gin Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys 675 680 685 Arg Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu 690 695 700 Val Lys Ala Phe Lys Gin Ala Val Ile Ala Arg Leu Gin Gin Thr Glu 705 710 715 720 Asp Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met 725 730 735 Ala Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gin 740 745 750 Tyr Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys 755 760 765 Thr Thr Val Ser Val Phe Gin Gly Arg Val Thr Ala Ser Ala Arg Arg 770 775 780 Ala Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gin Gin Ser Lys 785 790 795 800 Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala 805 810 815 Met Met Asn Thr Ala Ala Ala Gin Thr Leu Met Glu Arg Glu Ser Leu 820 825 830 Arg Glu Ser Gin Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp 835 840 845 Lys Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu 850 855 860 Trp Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu 865 870 875 880 Asp Asn Asp Arg Ile Ala Val Met 885 Gin Ser Gin Arg Tyr Val 890 Leu Gly 895 Asn Ser Ile Ala His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro 900 905 910 Page 318 of 3790 Lys Gin Gly Trp Leu Pro Pro Val Asn Thr Ala Ser Lys Thr Ala Page 319 of 3790 1155 1145 1150 Val Arg Ile Val Arg Arg Asn Ala Phe Gly Glu Pro Arg Leu Ser 1160 1165 1170 Ser Ala His His Met Pro Cys Ser Trp Gin Trp Arg His Glu 1175 1180 1185 67 166 PRT uncultured Termite 67 Met Asn Lys Val Gin Glu Ile Glu 1 5 Tyr Lys Lys Ile Arg Glu Lys Leu 10 15 Ala Asp Arg Glu Tyr Arg Ile Gly 20 Leu Asp Leu Gly Val Gly Ser Ile 25 30 Gly Tyr Val Val Val Ser Leu Lys 35 40 Glu Cys Asn Asp Leu Ser Tyr Leu 45 Pro Glu Asp Ile Ile Leu Ser Gly 50 55 Ser Arg Ile Phe Lys Ser Ser Ile 60 Gly Ala Val Glu Arg Arg Glu Phe 65 70 Arg Leu Gin Arg Asn Ser His Arg 75 80 His His Arg Glu Arg Met Arg Phe 85 Leu Trp Gin Leu Leu Ala Glu Lys 90 95 Gin Leu Ala Leu Gin Ser Ser Lys 100 Asp Leu Glu Lys Lys Glu Asn Ser 105 110 Ala Asp Cys Glu Thr Ser Gin Lys 115 120 Arg Phe Pro Ile Asn Ile Leu Lys 125 Glu Asp Pro Tyr Ile Leu Arg Tyr 130 135 Lys Ala Leu Glu Glu Lys Leu Ser 140 Leu Phe Gin Leu Gly Tyr Val Leu 145 150 Tyr His Ile Ala Asn His Ser Asn 155 160 Thr Ala Tyr Glu Asn Thr 165 68 Page 320 of 3790 Gin Gly Arg Asp Lys Thr Thr Gin Lys Ile Lys Gly Tyr Ala Leu Val Page 322 of 3790 Glu Gin Asn Phe Ile Cys Pro Phe Cys Ser Glu Lys Ile Thr Pro Asp 485 490 495 Asp Ile Ile Asn Ser Lys Val Asp Val Glu His Ile Phe Pro Ile Glu 500 505 510 Glu Ser Glu Asp Ile Thr Lys Asn Asn Leu Val Ile Ala His Asn Glu 515 520 525 Cys Asn Ala Asp Lys Gly Lys Lys Ser Pro Phe Asp Ala Phe Gly Asp 530 535 540 Lys Thr Ser Gly Lys Tyr Arg Trp Asn Cys Ile Leu His Asn Ala Gin 545 550 555 560 Lys Asn Leu Pro His Lys Val Trp Arg Phe Tyr Gin Gly Ser Leu Glu 565 570 575 Lys Phe Leu Glu Asn Lys Pro Met Ser Arg Arg Phe Gly Thr Asp Asn 580 585 590 Ser Tyr Ile Ser Lys Ile Ala Ala Arg Tyr Leu Ala Cys Leu Phe Asn 595 600 605 Asp Pro Tyr His Ser Glu Ile Phe Cys Ile Lys Ser Ser Leu Ile Ala 610 615 620 Gin Leu Arg Ile Ala Trp Asp Leu Asn Ser Ile Met Val Pro Leu Val 625 630 635 640 Lys Asn Ile Leu Ser Glu Lys Glu Leu Glu Glu Phe Lys Ile Ser Lys 645 650 655 Asn Lys Lys Ile Arg Ile Asp Asn Arg His His Ala Leu Asp Ala Ile 660 665 670 Val Ile Ala Tyr Ala Asn Arg Gly Tyr His Asn Phe Leu Asn Arg Ile 675 680 685 His Ala Lys Glu Tyr Lys Ile Asn Tyr Arg Glu Lys Ser Trp Leu Ser 690 695 700 Lys Ile Leu Leu Pro Pro Leu Asn Arg Asp Leu Glu Asp Phe Lys Ile 705 710 715 720 Ser Val Lys Asp Ser Ile Glu Lys Ala Asn Val Ser Ile Lys His Asp 725 730 735 Page 323 of 3790 His Asn Thr Asn Gly Ser Leu Val Lys Ala Thr Ala Tyr Lys Val Tyr 740 745 750 Tyr Ser Gly Ala Gly Glu Tyr Ile Ile Thr Thr Ser Lys Asn Val Glu 755 760 765 Glu Ile Ser Phe Lys Glu Lys Glu Asp Pro Lys Asp Thr Leu Tyr Arg 770 775 780 Ala Leu Cys Lys Phe Glu Cys Arg Asp Ile Asp Ile Lys Asp Glu Lys 785 790 795 800 Leu Ile Lys Lys Leu Lys Tyr Asn Ser Thr Leu Tyr Lys Lys Val Gin 805 810 815 Asn Asn Leu Ser Lys Ala Lys Gin Glu Leu Glu Gin Asp Asn Lys Lys 820 825 830 Thr Glu Glu Glu Gly Lys Lys Ser Gin Lys Ile Thr Glu Val Arg Ile 835 840 845 Tyr Lys Lys Ala Cys Ser Leu Val Lys Gly Gin Tyr Ile Gin Cys Gly 850 855 860 Ser Arg Leu Lys Asp Lys Phe Phe Ala Val Lys Glu Pro Thr Glu Ile 865 870 875 880 Lys Thr Gly Leu Gly Tyr Asp Thr Gly Asp Asn Leu Phe Leu Asp Leu 885 890 895 Tyr Tyr Asp Lys Thr Gly Lys Leu Cys Gly Glu Ile Ile Arg Lys Val 900 905 910 Asn Phe Asn Arg Asn Lys Pro Asn Tyr Gin Lys Glu Gly Tyr Thr Leu 915 920 925 Phe Glu Arg Ile Tyr Gin Ser Asp Ile Leu Glu Val Asp Thr Ser Glu 930 935 940 Asp Arg Ile Ser Leu Lys Asn Lys Thr Gly Ser Ala Pro Ser Asp Arg 945 950 955 960 Thr Phe Ile Lys Val Asn Thr Phe Thr Glu Val Asn Ala Tyr Phe Asp 965 970 975 Gly Lys Arg Asp Lys Ile Gin Ile Phe Phe Gly Asn Leu Leu Lys Ser 980 985 990 Page 324 of 3790 Ser Phe Lys Asn Asp Ser Phe Phe Ile Ser Ser Met Gin Lys Tyr Asn 995 1000 1005 Val Arg Lys Val Ile Leu Thr Ser Leu Gly Ile Ile Lys Tyr Arg Page 325 of 3790 Phe Cys Lys Asn Glu Ser Tyr Lys Glu His Lys Arg Asn Lys Gly Gly 180 185 190 Glu Tyr Ile Asn Ser Val Ala Arg Glu Leu Ile Glu Glu Glu Val Glu 195 200 205 Lys Ile Phe Val Lys Gin Arg Glu Lys Gly Asn Asn Phe Ala Asp Val 210 215 220 Asn Thr Glu Arg Glu Tyr Leu Lys Ile Ala Phe Ser Gin Lys Pro Ala 225 230 235 240 Gly Ser Ile Ser Lys Met Val Gly Phe Cys Thr Phe Glu Asn Gly Glu 245 250 255 Lys Arg Ala Pro Arg Asp Ser Tyr Ser Ala Glu Leu Phe Lys Val Leu 260 265 270 Cys Thr Ile Asn Asn Thr Thr Phe Thr Asp Met Lys Thr Gly Glu Ile 275 280 285 Arg Ser Phe Ser Lys Glu Glu Ile Gly Lys Thr Leu Glu Thr Val Lys 290 295 300 Asn Val Lys Asp Val Lys Tyr Ala Lys Ile Arg Lys Asp Leu Gly Leu 305 310 315 320 Glu Asp Ser Val Lys Phe Ser Gly Val Asp Tyr Arg Glu Asn Ala Lys 325 330 335 Ser Lys Gly Glu Gly Glu Ile Phe Val Ser Met Lys Thr Tyr His Glu 340 345 350 Ile Lys Ser Lys Ile Glu Lys Leu Ser Lys Glu Lys Trp Asp Asn Leu 355 360 365 Lys Gly Asn Thr Glu Leu Leu Asp Ser Ile Val Asn Ile Ile Ala Asn 370 375 380 Leu Lys Asp Asp Glu Ser Ile Lys Lys Glu Phe Gin Lys Leu Lys Ile 385 390 395 400 Asp Glu Asp Ile Ile Asp Val Leu Leu Asn Phe Glu Phe Lys Lys Phe 405 410 415 Ile Asn Leu Ser Phe Lys Ala Leu Arg Lys Ile Ile Pro Phe Gin Phe 900 905 910 Tyr Val Ser Asp Phe Lys Asn Lys Asp Leu Pro Asn Lys Ala Ile Ala 915 920 925 Page 328 of 3790 Leu Gly Asn Tyr Thr Glu Val Lys His Glu Lys Arg Met Pro Ala Page 329 of 3790 Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gin Gin Tyr Pro Thr Met Tyr 115 120 125 His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 130 135 140 Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 145 150 155 160 Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 165 170 175 Asn Glu Ile Phe Pro Ala Leu Gin Asp Ala Tyr Ala Gin Val Tyr Pro 180 185 190 Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 195 200 205 Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gin Arg Ala Leu 210 215 220 Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gin 225 230 235 240 Gin Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 245 250 255 Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 260 265 270 Thr Val Trp Asn Phe Ser Leu Gly Gin Leu Asp Asp Lys Trp Ala Gly 275 280 285 Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gin Ile 290 295 300 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Lys Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Ala Gin His His Glu 325 330 335 Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Thr Ala Lys Ala Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Page 330 of 3790 Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Leu Ala Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Lys Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Arg Tyr 530 535 540 Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 545 550 555 560 Ser Ile Glu Gin Lys Gin Gin Val Ile Arg Glu Leu Phe Glu Arg His 565 570 575 Asn Ser Val Thr Ile Lys Gin Phe Ala Glu Asn Leu Arg Ala His Gly 580 585 590 Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gin Leu Lys Ser Leu Leu Pro Phe Leu Ala 995 Ala Arg Ile Gly Thr Tyr Leu Leu Lys Arg Phe Pro Asn 1000 1005 Leu Gin Ala 1010 Phe Phe Thr Tyr 1015 Gly Lys Phe Lys Lys Ala Asp Val 1020 Lys Lys 1025 Leu Arg Gly Phe Asn 1030 Phe Ile Arg Asp Ile 1035 Thr His Ala Glu Asp Lys 1040 Ile Val Val Lys 1045 Asp Thr Gly Glu Val 1050 Ile Trp Asp Lys Lys Arg Asp Val Asp Glu 1055 1060 Leu Asp Arg Ile Tyr Asn Phe Lys 1065 Arg Met Leu 1070 Ile Thr His Glu Val 1075 His Phe Glu Lys 1080 Ala Asp Leu Phe Lys 1085 Gin Thr Val Tyr Gly 1090 Ala Lys Asp Ser Lys 1095 Glu Ala Gly Gly Lys Lys Gin Leu Ile Ser Lys Lys Lys Gly Tyr Pro Val Asp 1100 1105 1110 Page 333 of 3790 Page 334 of 3790 Arg Glu Val His Leu Ser Asp Leu 1355 1360 Page 335 of 3790 Lys Glu Leu Leu Ser Ala Ala Leu Ser Lys Ser Lys Arg Leu Glu Asn 210 215 220 Leu Ile Ser Leu Ile Pro Gly Gin Lys Lys Thr Gly Ile Phe Gly Asn 225 230 235 240 Ile Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ala Asn Phe 245 250 255 Gly Leu Ser Lys Asp Val Lys Leu Gin Leu Ala Lys Asp Thr Tyr Ala 260 265 270 Asp Asp Leu Asp Ser Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Thr Glu Ser Asp Glu Ile Thr Arg Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Val Lys Arg Tyr Arg Glu His His Lys Asp Leu Val Thr Leu Lys 325 330 335 Thr Leu Ile Lys Asp Gin Leu Pro Glu Lys Tyr Gin Glu Ile Phe Leu 340 345 350 Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Gin Val Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Tyr Leu Lys Pro Ile Leu Ala Arg Leu Asp 370 375 380 Gly Ser Glu Pro Leu Leu Leu Lys Ile Asp Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Glu Glu Leu His Ala Ile Leu Arg Arg Gin Glu Val Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Lys 435 Lys Ile Glu 440 Ser Leu Leu Thr Phe Arg 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly His Ser Arg Phe Ala Trp Page 338 of 3790 Leu Val Ser Asp Phe Arg Lys Glu Phe Gly Leu Tyr Lys Ile Arg Asp 965 970 975 Ile Asn His Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 980 985 990 Ala Lys Ala Ile Leu Gly Lys Tyr Pro Gin Leu Ala Pro Glu Phe Val 995 1000 1005 Tyr Gly Asp Tyr Pro Lys Tyr Asn Ser Phe Lys Glu Arg Gin Lys 1010 1015 1020 Ala Thr Gin Lys Met Leu Phe Tyr Ser Asn Ile Leu Lys Phe Phe 1025 1030 1035 Lys Asp Gin Glu Ser Leu His Val Asn Ser Asp Gly Glu Glu Ile 1040 1045 1050 Trp Asn Ala Asn Lys His Leu Pro Ile Ile Lys Asn Val Leu Ser 1055 1060 1065 Ile Pro Gin Val Asn Ile Val Lys Lys Thr Glu Val Gin Thr Gly 1070 1075 1080 Gly Phe Tyr Lys Glu Ser Ile Leu Ser Lys Gly Asn Ser Asp Lys 1085 1090 1095 Leu Ile Pro Arg Lys Asn Asn Trp Asp Thr Arg Lys Tyr Gly Gly 1100 1105 1110 Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Ile Ala Lys 1115 1120 1125 Met Glu Lys Gly Lys Ala Lys Val Leu Lys Pro Val Lys Glu Met 1130 1135 1140 Val Gly Ile Thr Ile Met Glu Arg Thr Ala Phe Glu Glu Asn Pro 1145 1150 1155 Val Val Phe Leu Glu Ala Arg Gly Tyr Arg Glu Ile Gin Glu His 1160 1165 1170 Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn 1175 1180 1185 Gly Arg Arg Arg Leu Leu Ala Ser Ala Ser Glu Leu Gin Lys Gly 1190 1195 1200 Page 339 of 3790 72 1341 PRT Ruminococcus lactaris 72 Met Gly Lys Gly Tyr Tyr Val Gly Leu Asp Met Gly Thr Gly Ser Val 15 10 15 Gly Trp Ala Val Thr Asp Glu Ser Tyr Gin Ile Leu Arg Arg His Gly 20 25 30 Lys Ala Met Trp Gly Val Arg Leu Phe Glu Ser Ala Lys Thr Ala Glu 35 40 45 Glu Arg Arg Met Phe Arg Thr Gly Arg Arg Arg Leu Asp Arg Arg Gly 50 55 60 Page 340 of 3790 Trp Arg Ile Glu Ile Leu Gin Glu Ile Phe Ala Glu Glu Ile Ser Arg 65 70 75 80 Val Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 85 90 95 Glu Asp Lys Arg Asp Ile Gin Gly Asn Cys Pro Glu Leu Pro Tyr Thr 100 105 110 Leu Phe Val Asp Lys Thr Phe Thr Asp Lys Asp Phe His Lys Lys Tyr 115 120 125 Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Glu Thr Glu Asp Thr 130 135 140 Pro Asp Met Arg Leu Val Tyr Leu Ala Leu His His Met Met Lys His 145 150 155 160 Arg Gly His Phe Leu Leu Ser Gly Asp Ile Ser Gin Val Thr Glu Phe 165 170 175 Lys Asn Thr Phe Asn Gin Phe Ile Glu Asn Ile Arg Asn Glu Glu Met 180 185 190 Asp Phe Glu Ile Glu Leu Asp Glu Ser Ala Val Gin Met Ile Glu Glu 195 200 205 Thr Leu Lys Asp Lys Asn Leu Thr Arg Ser Ala Lys Lys Ser Lys Leu 210 215 220 Val Lys Gly Leu Asn Ala Lys Asn Val Arg Asp Lys Ala Phe Leu Thr 225 230 235 240 Leu Leu Ser Gly Gly Thr Val Lys Leu Ser Asp Leu Phe Gly Met Glu 245 250 255 Glu Leu Asn Glu Gly Glu Arg Pro Lys Ile Ser Phe Ala Asp Asn Gly 260 265 270 Tyr Glu Glu Tyr Ala Ala Val Val Glu Met Glu Leu Gly Glu Leu Tyr 275 280 285 Tyr Ile Val Glu Ser Ala Lys Ala Val Tyr Asp Trp Ala Ile Leu Ser 290 295 300 Asp Ile Leu Gly Gly Ser Thr Ser Val Ser Asp Ala Lys Val Arg Ala Page 342 of 3790 Ile Tyr Arg Asp Val Phe Cys Arg Ser Arg Lys Val Thr Gin Lys Lys 565 570 575 Leu Lys Ser Tyr Leu Ile Arg Glu Gly Ile Ala Gly Lys Asn Val Glu 580 585 590 Leu Thr Gly Ile Asp Gly Asp Phe Lys Gly Ser Leu Thr Ala Tyr His 595 600 605 Asp Phe Lys Glu Lys Leu Ile Asp Val Glu Leu Thr Gin Lys Glu Lys 610 615 620 Glu Glu Ile Ile Leu Asn Ile Val Leu Phe Gly Asp Asp Lys Lys Leu 625 630 635 640 Leu Lys Gin Arg Leu Lys Lys Lys Phe Pro Gin Leu Thr Glu Lys Gin 645 650 655 Ile Asn Thr Val Thr Ala Leu Ser Tyr Lys Gly Trp Gly Arg Leu Ser 660 665 670 Lys Lys Leu Leu Glu Glu Val Thr Val Pro Ala Pro Glu Thr Gly Glu 675 680 685 Val Trp Asn Ile Ile Thr Ala Leu Trp Glu Thr Asn Asp Asn Phe Met 690 695 700 Gin Leu Leu Ser Lys Glu Tyr Gin Phe Ser Asp Arg Ile Glu Glu Phe 705 710 715 720 Asn Glu Glu Lys Ala Asp Pro Glu Val Ser Tyr Gin Thr Ile Glu Asp 725 730 735 Leu Tyr Val Ser Pro Ala Val Lys Arg Gin Ile Trp Gin Thr Leu Gin 740 745 750 Ile Ile Gin Glu Ile Glu Lys Val Met Gly Glu Lys Pro Lys Arg Val 755 760 765 Phe Val Glu Met Ala Arg Glu Lys Gin Glu Asn Lys Arg Thr Glu Ser 770 775 780 Arg Lys Lys Thr Leu Ser Asp Leu Tyr Thr Lys Cys Lys Lys Glu Glu 785 790 795 800 Pro Glu Trp Ile Glu Ala Leu Cys Thr Ser Leu Glu Lys His Glu Glu 805 810 815 Page 343 of 3790 Met Glu Lys Asn His Ile Leu Val Thr Arg Arg Ser Tyr Glu Val 1055 1060 1065 Page 344 of 3790 Ala Ala Asn Leu Lys Met Ile Gly Gly Pro Ala Ser Ala Gly Ile Page 345 of 3790 73 1003 PRT Gluconacetobacter diazotrophicus 73 Arg Leu Gly Arg Tyr Arg Thr Val Gly Glu Met Phe Ala Arg Asp Pro Page 348 of 3790 Tyr Ala Ala Arg Leu Phe Ala Glu Ala Val Lys Leu Leu Tyr Ala Phe 675 680 685 Gly Glu Arg Gin Glu Lys Gly Gly Asn Arg Arg Val Phe Thr Arg Pro 690 695 700 Gly Ala Leu Thr Ala Ala Leu Arg Gin Ala Trp Gly Val Glu Ser Leu 705 710 715 720 Lys Lys Gin Asp Gly Lys Arg Ile Asn Asp Asp Arg His His Ala Leu 725 730 735 Asp Ala Leu Thr Val Ala Ala Val Asp Glu Ala Glu Ile Gin Arg Leu 740 745 750 Thr Lys Ser Phe His Glu Trp Glu Gin Gin Gly Leu Gly Arg Pro Leu 755 760 765 Arg Arg Val Glu Pro Pro Trp Glu Ser Phe Arg Ala Asp Val Glu Ala 770 775 780 Thr Tyr Pro Glu Val Phe Val Ala Arg Pro Glu Arg Arg Arg Ala Arg 785 790 795 800 Gly Glu Gly His Ala Ala Thr Ile Arg Gin Val Lys Glu Arg Glu Cys 805 810 815 Thr Pro Ile Val Phe Glu Arg Lys Ala Val Ser Ser Leu Lys Glu Ala 820 825 830 Asp Leu Glu Arg Ile Lys Asp Gly Glu Arg Asn Glu Ala Ile Val Glu 835 840 845 Ala Ile Arg Ser Trp Ile Ala Thr Gly Arg Pro Ala Asp Ala Pro Pro 850 855 860 Arg Ser Pro Arg Gly Asp Ile Ile Thr Lys Ile Arg Leu Ala Thr Thr 865 870 875 880 Ile Lys Ala Ala Val Pro Val Arg Gly Gly Thr Ala Gly Arg Gly Glu 885 890 895 Met Val Arg Ala Asp Val Phe Ser Lys Pro Asn Arg Arg Gly Lys Asp 900 905 910 Glu Trp Tyr Leu Val Pro Val Tyr Pro His Gin Ile Met Asn Arg Lys 915 920 925 Page 349 of 3790 Page 350 of 3790 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg Page 352 of 3790 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Leu Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 785 790 795 800 Val Glu Thr Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Leu Lys 835 840 845 Asp Asp Ser 850 Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 855 860 Gly Lys 865 Ser Asp Asn Val 870 Pro Ser Glu Glu Val 875 Val Lys Lys Met Lys 880 Asn Tyr Trp Lys Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Page 353 of 3790 Page 354 of 3790 75 Page 355 of 3790 180 185 190 Gin Leu Arg Gly Glu 195 Glu Glu Glu 200 Glu Asn Lys Asp Lys 205 Leu Val Glu Phe Tyr Ala Leu Lys Val 210 Val 215 Ala Val Glu Asp Ser Gly Glu Lys 220 Lys Gly Lys Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val Tyr Page 357 of 3790 Leu Asn Gly Lys Lys Glu Ile Asp Gin Lys Ala Phe Leu Lys Tyr Pro 485 490 495 Val Phe Gly Leu Lys Lys Glu Ile Glu Asn Tyr Arg Trp Asn Tyr Val 500 505 510 Gin Asp Lys Pro Tyr Pro Cys Asn Glu Thr Arg Ser Leu Met Leu Ala 515 520 525 Arg Leu Glu Lys Cys Asp Ile Ser Ile Glu Phe Leu Thr Lys Glu Asn 530 535 540 Glu Glu Ala Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Asn Glu 545 550 555 560 Ile Val Lys Ala Leu Gin Lys Phe Ala Asp Lys His Asp Leu Asn Ala 565 570 575 Ser Phe Val Asp Val Phe Gin Lys Phe Pro Pro Phe Lys Lys Glu Tyr 580 585 590 Gly Ser Tyr Ser Ala Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg 595 600 605 Met Gly Lys Tyr Trp Ser Glu Asn Ser Ile Asp Lys Gly Thr Arg Glu 610 615 620 Arg Ile Asp Lys Ile Ile Thr Gly Glu Tyr Asp Glu Lys Ile Glu Asn 625 630 635 640 Arg Val Arg Glu Lys Ala Ile His Leu Ala Asp Val Ser Asp Phe Lys 645 650 655 Gly Leu Pro Leu Trp Leu Val Cys Tyr Ile Val Tyr Gly Arg His Ser 660 665 670 Glu Ala Lys Glu Ile Ile Gin Trp Lys Ser Pro Ala Asp Ile Asp Ser 675 680 685 Tyr Leu Arg Ser Phe Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu 690 695 700 Gin Ile Ile Ile Glu Thr Leu Arg Val Val Arg Asp Ile Trp Lys Gin 705 710 715 720 Val Gly Asn Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu Met Lys 725 730 735 Page 358 of 3790 Asn Pro Ala Asp Lys Arg Lys Lys Met Thr Gin Gin Met Ser Glu Asn 740 745 750 Glu Asn Thr Asn Leu Arg Ile Lys Tyr Leu Leu Thr Glu Phe Leu Asn 755 760 765 Pro Glu Tyr Glu Val Glu Asn Val Arg Pro Tyr Ser Pro Ser Gin Gin 770 775 780 Asp Ile Leu Arg Ile Tyr Glu Glu Gly Val Leu Asn Ser Val Ser Asp 785 790 795 800 Leu Pro Glu Glu Ile Ser Asp Ile Leu Lys Lys Phe Thr Glu Thr Asp 805 810 815 Leu Lys Lys Arg Pro Ser Arg Ser Glu Val Leu Arg Tyr Lys Leu Trp 820 825 830 Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Glu Val Ile Pro Leu 835 840 845 Gly Lys Leu Phe Thr Pro Ala Tyr Glu Ile Glu His Val Ile Pro Gin 850 855 860 Ser Tyr Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala 865 870 875 880 Glu Val Asn Lys Leu Lys Ser Asn Leu Leu Gly His Glu Phe Ile Val 885 890 895 Lys His His Gly Glu Ile Val Glu Leu Pro Phe Gly Lys Lys Val Arg 900 905 910 Ile Phe Thr Val Asp Glu Tyr Glu Gin Phe Val Lys Asp Asn Tyr Ser 915 920 925 Arg Thr Arg Ser Lys Met Lys Lys Leu Leu Met Asp Asp Ile Pro Glu 930 935 940 Glu Phe Val Thr Arg Gin Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val 945 950 955 960 Val Lys Ser Leu Leu Ser Asn Ile Val Arg Glu Lys Gly Glu Glu Glu 965 970 975 Ala Ile Ser Lys Asn Val Ile Pro Cys Thr Gly Gly Val Thr Asp Arg 980 985 990 Page 359 of 3790 Leu Lys Lys Asp Trp Gly Ile Asn Glu Val Trp Asn Lys Ile Ile Leu 995 1000 1005 Lys Arg Ile Lys Lys Tyr Phe Glu Asp Asn Arg Glu Thr Trp Ser Page 361 of 3790 Lys 76 1426 PRT Capnocytophaga sputigena 76 Page 362 of 3790 Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gin Leu Ser Leu Gin Leu Leu 165 170 175 Gin Gin Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gin 180 185 190 Arg Glu Phe Asp Leu Val Trp Asn Phe Gin Lys Gin Phe Tyr Pro Asp 195 200 205 Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gin Gly Lys Gly Lys Asp 210 215 220 Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 225 230 235 240 Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gin Ala Tyr Gin Trp Arg 245 250 255 Ala Glu Ala Ile Ser Lys Gin Leu Ser Lys Glu Glu Val Ala Tyr Val 260 265 270 Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 275 280 285 Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gin Thr Val 290 295 300 Gly Gin Tyr Leu Tyr Ala Gin Leu Gin Glu Asn Arg His Asn Ser Leu 305 310 315 320 Lys Asn Lys Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu Arg 325 330 335 Ile Trp Glu Thr Gin Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 340 345 350 Lys Lys Gin Ile Arg Asp Val Val Ile Phe Tyr Gin Arg Lys Leu Lys 355 360 365 Ser Gin Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 370 375 380 Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Thr Ile Gly Ala Arg 385 390 395 400 Val Val Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys Ile Trp Gin 405 410 415 Page 363 of 3790 Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 420 425 430 Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gin 435 440 445 Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gin Leu Leu Phe Asp Glu 450 455 460 Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 465 470 475 480 Gly Tyr Ser Pro Gin Glu Trp Glu Ile Asn Tyr Asn Gin Leu Glu Gly 485 490 495 Asn Arg Thr Gin Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 500 505 510 Met Glu Ala His Asp Val Lys Asp Ile Leu Gin Ile Lys Ser Ala Lys 515 520 525 Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Lys 530 535 540 Glu Lys Val Lys Asp Ile Phe Gin Ala Leu Gly Ile Cys Thr Lys Ile 545 550 555 560 Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Lys Gin Asp 565 570 575 Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 580 585 590 Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 595 600 605 Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gin Asp 610 615 620 Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 625 630 635 640 Ile Lys Glu Asn Gin Tyr Ser Lys Ala Cys Glu Leu Ala Gly Tyr Lys 645 650 655 His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 660 665 670 Page 364 of 3790 Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 675 680 685 Val Glu Lys Ile Leu Asn Gin Met Ile Asn Val Val Asn Ala Leu Ile 690 695 700 Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 705 710 715 720 His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 725 730 735 Ala Gin Lys Arg Tyr Glu Met Thr Gin Asn Ile Asn Lys Ala Lys Leu 740 745 750 Glu His Gin Lys Ile Ser Glu Ile Leu Gin Lys Lys Phe Gly Ile Lys 755 760 765 Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gin Glu Leu 770 775 780 Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Ala Pro Ile Ala Arg 785 790 795 800 Asp Met Leu Phe Ser Lys Asn Ile Glu Ile Glu His Ile Val Pro Lys 805 810 815 Ala Arg Val Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Thr Phe His 820 825 830 Arg Ile Asn Ser Asn Lys Gly Glu Tyr Thr Ala Phe Asp Tyr Ile Thr 835 840 845 Ser Leu Asn Ser Glu Glu Glu Leu Asn Gin Tyr Leu Thr Arg Val Glu 850 855 860 Asn Ala Tyr Lys Thr Lys Ser Ile Ser Leu Thr Lys Tyr Lys Asn Leu 865 870 875 880 Leu Lys Lys Ala Ser Glu Ile Gly Asp Gly Phe Ile Asn Arg Asp Leu 885 890 895 Arg Asp Thr Gin Tyr Ile Ala Lys Lys Ala Lys Glu Ile Leu Phe Gin 900 905 910 Val Thr Lys Asn Val Leu Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu Page 365 of 3790 Page 367 of 3790 Lys Arg Glu Gly Leu Ser Gly Leu Lys Asp Ile Val Lys Val Arg 1400 1405 1410 Ile Asn His Leu Gly Asp Ile Val Ser Ile Gly Glu Tyr 1415 1420 1425 77 1443 PRT Parabacteroides johnsonii 77 Met Ile Lys Leu Leu Tyr Leu Glu Lys Leu Lys Gin Tyr Thr Met Lys 15 10 15 Lys Ile Leu Gly Leu Asp Leu Gly Thr Ser Ser Ile Gly Trp Ala Leu 20 25 30 Val Asn Glu Ala Glu Asn Ser Asp Glu Val Ser Ser Ile Ile Lys Leu 35 40 45 Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Met Gin Asn Phe Glu 50 55 60 Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys Arg Ser 65 70 75 80 Met Arg Arg Asn Leu Gin Arg Tyr Lys Leu Arg Arg Asp Ala Leu Ile 85 90 95 Glu Leu Leu Lys Lys Val Gly Phe Ile Thr Asp Lys Thr Ile Leu Ser 100 105 110 Glu Gin Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg Ala Lys 115 120 125 Ala Ala Glu Glu Glu Ile Ser Leu Lys Glu Leu Ala Arg Val Leu Leu 130 135 140 Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys Gly 145 150 155 160 Glu Glu Glu Gly Ala Leu Ile Asp Gly Met Glu Ile Ala Lys Lys Leu 165 170 175 Tyr Asp Glu Asp Leu Thr Pro Gly Gin Leu Cys Leu Gin Leu Leu Glu 180 185 190 Page 368 of 3790 Ser Gly Lys Lys Phe Phe Pro Asp Phe Tyr Arg Ser Asp Leu Gin Glu 195 200 205 Glu Phe Asn Lys Ile Trp Asp Phe Gin Lys Gin Phe Asn Leu Phe Ser 210 215 220 Phe Cys Asp Val Ala Lys Glu Glu Val Lys Gly Lys Asn Lys Ser Gin 225 230 235 240 Thr Trp Ala Ile Leu Ala Lys Tyr Phe Val Glu Thr Lys Lys Val Asn 245 250 255 Val Trp Asn Glu His Glu Ala Gin Thr Glu Asn Arg Glu Glu Val Tyr 260 265 270 Lys Leu Val Gly Leu Lys Arg Thr Val Lys Gly Glu Glu Leu Lys Lys 275 280 285 Glu Asn Tyr Arg Trp Arg Val Gin Ala Leu Thr Glu Gin Leu Asp Leu 290 295 300 Glu Lys Ile Ala Val Val Leu Gin Glu Ile Asn Gly Gin Ile Ser Ala 305 310 315 320 Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val Leu Tyr 325 330 335 Phe Asn Arg Gin Thr Val Gly Gin Tyr Gin Met Ala Glu Leu Asn Lys 340 345 350 Asn Pro Asn Met Ser Leu Arg Asn Met Val Phe Tyr Arg Gin Asp Tyr 355 360 365 Leu Asp Glu Phe Asn Val Ile Trp Glu Lys Gin Ala Glu Phe His Lys 370 375 380 Glu Leu Thr Pro Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile Ile Phe 385 390 395 400 Tyr Gin Arg Arg Leu Lys Ser Gin Lys Gly Leu Ile Ser Phe Cys Glu 405 410 415 Phe Glu Asn Arg Glu Val Val Val Glu Lys Glu Gly Lys Lys Gin Thr 420 425 430 Lys Ile Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu Phe Gin 435 440 445 Page 369 of 3790 Glu Phe Lys Ile Trp Gin Thr Leu Asn Asn Ile Glu Val Phe Val Gly 450 455 460 Glu Lys Lys Gly Lys Arg Lys Lys Ser Asn Val Ser Ser Asp Leu Phe 465 470 475 480 Gly Asp Thr Glu Asp Ala Leu Ile Thr Glu Gly Arg Arg Phe Leu Tyr 485 490 495 Gin Glu Glu Lys Lys Ile Leu Ala Lys Glu Leu Ser Ile Lys Lys Gly 500 505 510 Leu Thr Lys Ala Glu Ile Leu Arg Leu Leu Phe Glu Asn Pro Gin Glu 515 520 525 Leu Asp Ile Asn Phe Lys Gin Ile Asp Gly Asn Gin Thr Gly Phe Ala 530 535 540 Leu Phe Ser Ala Tyr Ser Asn Met Ile Glu Lys Tyr Gly Tyr Glu Pro 545 550 555 560 Leu Asp Phe Lys Lys Pro Ala Glu Asp Leu Ile Ser Gin Leu Lys Thr 565 570 575 Val Phe Thr Asp Leu Gly Trp Asn Thr Asp Leu Leu Phe Ile Asp Leu 580 585 590 Asp Lys Glu Asn Lys Glu Trp Glu Lys Gin Pro Tyr Phe Arg Leu Trp 595 600 605 His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly Asn Gly 610 615 620 Lys Leu Ile Glu Lys Ile Met Gin Leu Cys Gly Ile Glu Lys Glu Tyr 625 630 635 640 Ala Ile Glu Leu Ala Asn Val Ser Leu Gin Asp Asp Tyr Gly Ser Leu 645 650 655 Ser Ala Lys Ala Ile Lys Lys Ile Leu Leu Tyr Leu Lys Glu Gly Asn 660 665 670 Gin Tyr Asp Met Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser Lys Ser 675 680 685 Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Asp Lys Leu Page 371 of 3790 Page 372 of 3790 Page 373 of 3790 Val Arg Ile Asn His Ile Gly Gin Ile Val Ser Val Gly Glu Tyr Page 374 of 3790 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Page 377 of 3790 Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970 975 Arg Gin Arg Glu Asp Phe Lys Lys 980 79 1082 PRT Neisseria meningitidis 79 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Page 378 of 3790 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Page 379 of 3790 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 80 1021 PRT Clostridium cellulolyticum 80 Met Lys Tyr Thr Leu Gly Leu Asp Val Gly Ile Ala Ser Val Gly Trp 15 10 15 Ala Val Ile Asp Lys Asp Asn Asn Lys Ile Ile Asp Leu Gly Val Arg 20 25 30 Cys Phe Asp Lys Ala Glu Glu Ser Lys Thr Gly Glu Ser Leu Ala Thr 35 40 45 Ala Arg Arg 50 Ile Ala Arg Gly Met 55 Arg Arg Arg Ile Ser Arg Arg Ser Gin Arg Leu Arg Leu Val Lys Lys Leu Phe Val Gin Tyr Glu Ile Ile 65 70 75 80 Page 382 of 3790 Lys Asp Ser Ser Glu Phe Asn Arg Ile Phe Asp Thr Ser Arg Asp Gly 85 90 95 Trp Lys Asp Pro Trp Glu Leu Arg Tyr Asn Ala Leu Ser Arg Ile Leu 100 105 110 Lys Pro Tyr Glu Leu Val Gin Val Leu Thr His Ile Thr Lys Arg Arg 115 120 125 Gly Phe Lys Ser Asn Arg Lys Glu Asp Leu Ser Thr Thr Lys Glu Gly 130 135 140 Val Val Ile Thr Ser Ile Lys Asn Asn Ser Glu Met Leu Arg Thr Lys 145 150 155 160 Asn Tyr Arg Thr Ile Gly Glu Met Ile Phe Met Glu Thr Pro Glu Asn 165 170 175 Ser Asn Lys Arg Asn Lys Val Asp Glu Tyr Ile His Thr Ile Ala Arg 180 185 190 Glu Asp Leu Leu Asn Glu Ile Lys Tyr Ile Phe Ser Ile Gin Arg Lys 195 200 205 Leu Gly Ser Pro Phe Val Thr Glu Lys Leu Glu His Asp Phe Leu Asn 210 215 220 Ile Trp Glu Phe Gin Arg Pro Phe Ala Ser Gly Asp Ser Ile Leu Ser 225 230 235 240 Lys Val Gly Lys Cys Thr Leu Leu Lys Glu Glu Leu Arg Ala Pro Thr 245 250 255 Ser Cys Tyr Thr Ser Glu Tyr Phe Gly Leu Leu Gin Ser Ile Asn Asn 260 265 270 Leu Val Leu Val Glu Asp Asn Asn Thr Leu Thr Leu Asn Asn Asp Gin 275 280 285 Arg Ala Lys Ile Ile Glu Tyr Ala His Phe Lys Asn Glu Ile Lys Tyr 290 295 300 Ser Glu Ile Arg Lys Leu Leu Asp Ile Glu Pro Glu Ile Leu Phe Lys 305 310 315 320 Ala His Asn Leu Thr His Lys Asn Pro Ser Gly Asn Asn Glu Ser Lys 325 330 335 Page 383 of 3790 Lys Phe Tyr Glu Met Lys Ser Tyr His Lys Leu Lys Ser Thr Leu Pro 340 345 350 Thr Asp Ile Trp Gly Lys Leu His Ser Asn Lys Glu Ser Leu Asp Asn 355 360 365 Leu Phe Tyr Cys Leu Thr Val Tyr Lys Asn Asp Asn Glu Ile Lys Asp 370 375 380 Tyr Leu Gin Ala Asn Asn Leu Asp Tyr Leu Ile Glu Tyr Ile Ala Lys 385 390 395 400 Leu Pro Thr Phe Asn Lys Phe Lys His Leu Ser Leu Val Ala Met Lys 405 410 415 Arg Ile Ile Pro Phe Met Glu Lys Gly Tyr Lys Tyr Ser Asp Ala Cys 420 425 430 Asn Met Ala Glu Leu Asp Phe Thr Gly Ser Ser Lys Leu Glu Lys Cys 435 440 445 Asn Lys Leu Thr Val Glu Pro Ile Ile Glu Asn Val Thr Asn Pro Val 450 455 460 Val Ile Arg Ala Leu Thr Gin Ala Arg Lys Val Ile Asn Ala Ile Ile 465 470 475 480 Gin Lys Tyr Gly Leu Pro Tyr Met Val Asn Ile Glu Leu Ala Arg Glu 485 490 495 Ala Gly Met Thr Arg Gin Asp Arg Asp Asn Leu Lys Lys Glu His Glu 500 505 510 Asn Asn Arg Lys Ala Arg Glu Lys Ile Ser Asp Leu Ile Arg Gin Asn 515 520 525 Gly Arg Val Ala Ser Gly Leu Asp Ile Leu Lys Trp Arg Leu Trp Glu 530 535 540 Asp Gin Gly Gly Arg Cys Ala Tyr Ser Gly Lys Pro Ile Pro Val Cys 545 550 555 560 Asp Leu Leu Asn Asp Ser Leu Thr Gin Ile Asp His Ile Tyr Pro Tyr 565 570 575 Ser Arg Ser Met Asp Asp Ser Tyr Met Asn Lys Val Leu Val Leu Thr 580 585 590 Page 384 of 3790 Asp Glu Asn Gin Asn Lys Arg Ser Tyr Thr Pro Tyr Glu Val Trp Gly 595 600 605 Ser Thr Glu Lys Trp Glu Asp Phe Glu Ala Arg Ile Tyr Ser Met His 610 615 620 Leu Pro Gin Ser Lys Glu Lys Arg Leu Leu Asn Arg Asn Phe Ile Thr 625 630 635 640 Lys Asp Leu Asp Ser Phe Ile Ser Arg Asn Leu Asn Asp Thr Arg Tyr 645 650 655 Ile Ser Arg Phe Leu Lys Asn Tyr Ile Glu Ser Tyr Leu Gin Phe Ser 660 665 670 Asn Asp Ser Pro Lys Ser Cys Val Val Cys Val Asn Gly Gin Cys Thr 675 680 685 Ala Gin Leu Arg Ser Arg Trp Gly Leu Asn Lys Asn Arg Glu Glu Ser 690 695 700 Asp Leu His His Ala Leu Asp Ala Ala Val Ile Ala Cys Ala Asp Arg 705 710 715 720 Lys Ile Ile Lys Glu Ile Thr Asn Tyr Tyr Asn Glu Arg Glu Asn His 725 730 735 Asn Tyr Lys Val Lys Tyr Pro Leu Pro Trp His Ser Phe Arg Gin Asp 740 745 750 Leu Met Glu Thr Leu Ala Gly Val Phe Ile Ser Arg Ala Pro Arg Arg 755 760 765 Lys Ile Thr Gly Pro Ala His Asp Glu Thr Ile Arg Ser Pro Lys His 770 775 780 Phe Asn Lys Gly Leu Thr Ser Val Lys Ile Pro Leu Thr Thr Val Thr 785 790 795 800 Leu Glu Lys Leu Glu Thr Met Val Lys Asn Thr Lys Gly Gly Ile Ser 805 810 815 Asp Lys Ala Val Tyr Asn Val Leu Lys Asn Arg Leu Ile Glu His Asn 820 825 830 Asn Lys Pro Leu Lys Ala Phe Ala Glu Lys Ile Tyr Lys Pro Leu Lys Page 385 of 3790 Arg Arg Gly Met Glu Lys Tyr Asn Ser Phe Lys Ser Asn 1010 1015 1020 81 1131 PRT Acidovorax ebreus 81 Phe Asp Lys Ala Glu Thr Ala Lys Glu Gly Asp Pro Leu Asn Leu Thr Page 386 of 3790 40 45 Arg Arg Gin Ala Arg Leu Leu Arg Arg Arg Leu Tyr Arg Arg Ala Trp 50 55 60 Arg Leu Thr Gin Leu Ser Arg Leu Leu Lys Arg Lys Gly Leu Ile Ala 65 70 75 80 Asp Ala Lys Leu Phe Ala Lys Ala Pro Ser Tyr Gly Asp Ser Ala Trp 85 90 95 Glu Leu Arg Arg Gin Gly Leu Asp Arg Leu Leu Thr Pro Leu Glu Trp 100 105 110 Ala Arg Val Ile Tyr His Gin Cys Lys His Arg Gly Phe His Trp Thr 115 120 125 Ser Lys Ala Glu Glu Ala Lys Ala Asp Ser Asp Ala Glu Gly Gly Arg 130 135 140 Val Lys Gin Gly Leu Ala His Thr Lys Ala Leu Met Gin Ala Lys Asn 145 150 155 160 Tyr Arg Ser Ala Ala Glu Met Val Leu Ala Glu Phe Pro Asp Ala Gin 165 170 175 Arg Asn Lys Arg Gly Gin Tyr Asp Lys Ala Leu Ser Arg Val Leu Leu 180 185 190 Gly Glu Glu Leu Ala Leu Leu Phe Ala Thr Gin Arg Arg Leu Gly Asn 195 200 205 Pro His Ala Ser Asp Phe Phe Glu Lys Leu Ile Leu Gly Asp Gly Asp 210 215 220 Arg Lys Ser Gly Leu Phe Trp Gin Gin Lys Pro Ala Leu Ser Gly Ala 225 230 235 240 Asp Leu Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Lys Gly Glu Tyr 245 250 255 Arg Ala Pro Lys Ala Ser Phe Ser Val Glu Arg His Val Trp Leu Thr 260 265 270 Arg Leu Asn Asn Leu Arg Ile Val Val Asp Gly Arg Ser Arg Pro Leu 275 280 285 Page 387 of 3790 Asn Glu Ala Glu Arg Gin Ala Ala Leu Leu Leu Pro Tyr Gin Thr Glu 290 295 300 Thr Ser Lys Tyr Lys Thr Leu Lys Asn Ala Phe Ile Lys Ala Gly Leu 305 310 315 320 Trp Gly Asp Gly Val Arg Phe Gly Gly Leu Ala Tyr Pro Ser Gin Ala 325 330 335 Gin Ile Asp Ala Glu Lys Thr Lys Asp Pro Glu Asp Gin Phe Leu Val 340 345 350 Lys Leu Pro Ala Trp His Glu Leu Arg Lys Ala Phe Lys Ala Ala Gly 355 360 365 His Glu Ala Leu Trp Gin Gin Ile Ser Thr Pro Ala Leu Asp Gly Asp 370 375 380 Pro Thr Leu Leu Asp Gin Ile Ala Thr Val Leu Ser Val Tyr Lys Asp 385 390 395 400 Gly Ala Glu Val Val Gin Gin Leu Arg Gin Leu Ala Leu Pro Glu Pro 405 410 415 Ala Ala Ser Ile Ala Val Leu Glu Lys Ile Ser Phe Asp Lys Phe Ser 420 425 430 Ser Leu Ser Leu Lys Ala Leu Arg Arg Ile Val Pro Leu Met Gin Ser 435 440 445 Gly Leu Arg Tyr Asp Glu Ala Val Ala Gin Ile Pro Glu Tyr Gly His 450 455 460 His Ser Gin Arg Ile Glu Pro Gly Ala Ala Lys His Leu Tyr Leu Pro 465 470 475 480 Pro Phe Tyr Glu Ala Gin Arg Lys Tyr Ala Gly Lys Gly Asp His Ile 485 490 495 Gly Ser Met Gin Phe Arg Asp Asp Ala Asp Ile Pro Arg Asn Pro Val 500 505 510 Val Leu Arg Ala Leu Asn Gin Ala Arg Lys Val Val Asn Ala Leu Ile 515 520 525 Arg Glu Tyr Gly Ser Pro Ile Ala Val Asn Ile Glu Met Ala Arg Asp 530 535 540 Page 388 of 3790 Leu Ser Arg Pro Leu Asp Glu Arg Asn Lys Val Lys Arg Ala Gin Glu 545 550 555 560 Glu Phe Arg Asp Arg Asn Asp Arg Ala Arg Ser Glu Phe Glu Arg Asp 565 570 575 Phe Gly Tyr Lys Pro Lys Ala Ala Ala Phe Glu Lys Trp Met Leu Tyr 580 585 590 Arg Glu Gin Leu Gly Gin Cys Ala Tyr Ser Gin Gin Pro Leu Asp Ile 595 600 605 Gin Arg Val Leu Asp Asp His Asn Tyr Ala Gin Val Asp His Ala Leu 610 615 620 Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Lys Asn Asn Lys Val Leu Val 625 630 635 640 Leu Thr His Glu Asn Gin Asn Lys Gly Asn Arg Thr Ala Phe Glu Tyr 645 650 655 Leu Thr Ser Phe Pro Asp Gly Glu Asp Gly Glu Arg Trp Arg Thr Phe 660 665 670 Val Ala Trp Val Gin Gly Asn Lys Ala Tyr Arg Met Ala Lys Arg Asn 675 680 685 Arg Leu Leu Arg Lys Asn Tyr Gly Val Asp Glu Ser Lys Gly Phe Ile 690 695 700 Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile Cys Lys Phe Phe Lys Asn 705 710 715 720 Tyr Val Glu Glu His Leu Gin Leu Ala Ala Arg Ala Asp Gly Asp Thr 725 730 735 Ala Arg Arg Cys Val Val Val Asn Gly Gin Leu Thr Ala Phe Leu Arg 740 745 750 Ala Arg Trp Gly Leu Thr Lys Val Arg Gly Asp Ser Asp Arg His His 755 760 765 Ala Leu Asp Ala Ala Val Val Ala Ala Cys Thr His Gly Met Val Lys 770 775 780 Ala Leu Ala Asp Tyr Ser Arg Arg Lys Glu Ile Ser Phe Leu Gin Glu 785 790 795 800 Page 389 of 3790 Thr Leu Ile Asp Glu Ser Phe Ala Phe Leu Phe Ser Val Tyr Pro Page 390 of 3790 1040 1045 1050 Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Ser Asp Asn Glu Page 391 of 3790 115 120 125 Ala Gly Arg Ser Asp Tyr Ala Lys Ala Ile Glu Arg Asn Arg Gin Leu 130 135 140 Leu Thr Ser Lys Thr Pro Gly Glu Ile Gin Leu Glu Arg Leu Glu Lys 145 150 155 160 Tyr Gly Gin Leu Arg Gly Asn Phe Thr Ile Ile Asp Glu Glu Gly Gin 165 170 175 Ser Gin Gin Ile Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu 180 185 190 Val Glu Lys Ile Leu Asp Cys Gin Lys Met Tyr His Lys Phe Ile Ser 195 200 205 Asp Glu Phe Cys Asp Lys Leu Ile Glu Leu Leu Arg Glu Lys Arg Lys 210 215 220 Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile 225 230 235 240 Tyr Arg Thr Asp Gly Thr Thr Leu Glu Asn Leu Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Gin Tyr Arg Ser Ser Arg Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Gin Glu Gin Lys Glu Phe Leu 290 295 300 Val Asn Tyr Ala Lys Glu Thr Ser Val Leu Gly Ala Gly Lys Ile Leu 305 310 315 320 Gin Gin Ile Ala Lys Leu Ala Asp Cys Lys Val Glu Asp Ile Arg Gly 325 330 335 Tyr Arg Leu Asp Asn Lys Asp Lys Pro Glu Leu His Thr Phe Glu Thr 340 345 350 Tyr Arg Ala Met Lys Gly Leu Val Pro Leu Val Asp Ile Gly Val Leu 355 360 365 Page 392 of 3790 Ser Arg Glu Gin Leu Asp Ile Leu Ala Asp Ile Leu Thr Leu Asn Thr 370 375 380 Asp Phe Glu Gly Ile Arg Glu Ala Leu Lys Lys Gin Leu Pro Asn Val 385 390 395 400 Phe Asp Glu Lys Gin Val Lys Gly Leu Ala Ser Phe Arg Lys Ser Lys 405 410 415 Ser Gin Leu Phe Ala Lys Gly Trp His Asn Leu Ser Gin Lys Ile Met 420 425 430 Leu Glu Val Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gin Met Thr 435 440 445 Ile Leu Thr Arg Leu Gly Lys Phe Glu Lys Ser Ser Val Ala Glu Tyr 450 455 460 Pro Ser Ser Ile Asn Val Asp Glu Ile Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Ile Arg Gin Thr Ile Lys Ile Ile Asn Ala Ser 485 490 495 Ile Lys Lys Trp Gly Glu Phe Asp Gin Ile Val Ile Glu Met Pro Arg 500 505 510 Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gin Lys 515 520 525 Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 530 535 540 Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 545 550 555 560 Gin Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Ile Tyr Thr Gly Gin Pro Ile Ser Ile His Asp Leu Ile His Asn Gin 580 585 590 Asn Gin Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 595 600 605 Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gin Glu 610 615 620 Page 393 of 3790 Lys Ala Gin Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 625 630 635 640 Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 645 650 655 Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 660 665 670 Phe Glu Val Arg Ser Lys Phe Ile Gin Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gin Asp Tyr Phe Lys Ile 690 695 700 Ser Gly Ile Gin Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg 740 745 750 Leu Trp Lys Lys Gin Glu Ser Pro Leu Val Val Asp Tyr Gin Glu Gly 755 760 765 Arg Gin Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 770 775 780 Gin Tyr Lys Glu Leu Val Tyr Gin Pro Pro Tyr Gin Gly Phe Val Asn 785 790 795 800 Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gin 805 810 815 Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 820 825 830 Thr Arg Asn Ala Gin Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 835 840 845 Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gin Ala Gly Tyr Glu Ala Phe 850 855 860 Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 865 870 875 880 Page 394 of 3790 Glu His Pro Gin Leu Lys Phe Lys Lys Page 395 of 3790 Tyr His Ala Leu Lys Val Val Ser Val Glu Asp Ser Gly Glu Arg Lys Page 397 of 3790 Leu Asp Val Asp Val Thr Arg Glu Phe Leu Pro Ser Glu Glu Asp Tyr 465 470 475 480 Val Lys Leu Phe Asp Trp Leu Asn Glu Arg Lys Glu Ile Ser Gin Lys 485 490 495 Phe Leu Leu Ala Tyr Lys Pro Phe Gly Leu Lys Lys Asn Glu Gin Ala 500 505 510 Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys Asn Glu 515 520 525 Thr Arg Ala Glu Ile Lys Ser Arg Leu Ser Lys Ala Gly Val Pro Glu 530 535 540 Glu Phe Leu Thr Glu Glu Lys Glu Glu Ala Leu Trp His Ile Leu Tyr 545 550 555 560 Ser Ile Ser Asp Lys Lys Glu Leu Thr Lys Ala Leu Gly Thr Phe Ala 565 570 575 Ala Lys Asn Cys Leu Asn Glu Ser Phe Val Glu Val Phe Ala Lys Ile 580 585 590 Pro Pro Phe Glu Ser Asn Tyr Ala Ala Tyr Ser Leu Lys Ala Ile Arg 595 600 605 Lys Leu Leu Ala Leu Met Arg Met Gly Lys Tyr Trp Asn Glu Gin Ala 610 615 620 Ile Asp Arg Gin Thr Arg Asp Arg Ile Glu Lys Ile Leu Thr Gly Glu 625 630 635 640 Tyr Asp Glu Thr Ile Arg Ser Arg Val Arg Glu Lys Ala Met Leu Leu 645 650 655 Thr Asp Ile Ser Ser Phe Arg Gly Leu Pro Leu Trp Leu Ala Cys Tyr 660 665 670 Ile Val Tyr Asp Arg His Ser Glu Ser Lys Glu Leu Val Lys Trp Glu 675 680 685 Thr Pro Ala Asp Ile Asp His Phe Leu Ser Lys Phe Lys Gin Asn Ser 690 695 700 Leu Arg Asn Pro Ile Val Glu Gin Val Ile Thr Glu Ser Leu Arg Thr 705 710 715 720 Page 398 of 3790 Val Arg Asp Ile Trp Lys Gin Glu Gly Lys Ile Asp Glu Ile His Val 725 730 735 Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Lys Glu Arg Ala Arg Ile 740 745 750 Thr Ala Gin Val Gin Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala 755 760 765 Leu Leu Ala Glu Phe Met Asn Pro Glu Phe Glu Ile Glu Asn Val His 770 775 780 Pro Tyr Ser Pro Gly Gin Gin Glu Ile Leu Arg Ile Tyr Glu Asp Gly 785 790 795 800 Val Leu Ser Gly Ile Ala Glu Lys Asp Leu Pro Asp Asp Ile Thr Ala 805 810 815 Ile Leu Lys Lys Phe Arg Glu Asn Asp Val Lys Lys Arg Pro Thr Thr 820 825 830 Ser Glu Val Leu Arg Tyr Lys Leu Trp Leu Glu Gin Arg Tyr Arg Ser 835 840 845 Pro Tyr Thr Gly Arg Val Ile Pro Leu Gly Lys Leu Phe Thr Pro Ala 850 855 860 Tyr Glu Ile Glu His Val Ile Pro Gin Ser Arg Tyr Phe Asp Asp Ser 865 870 875 880 Ile Ser Asn Lys Val Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp 885 890 895 Asn Cys Leu Gly Tyr Glu Phe Ile Lys Lys His Ser Gly Glu Met Val 900 905 910 Glu Leu Gly Asn Gly Glu Thr Val Pro Val Phe Ser Val Glu Glu Tyr 915 920 925 Glu Arg Phe Val Lys Glu Ser Tyr Phe Gly Asn Ser Lys Lys Met Lys 930 935 940 Lys Leu Leu Leu Glu Asp Ile Pro Asp Ser Phe Ile Glu Arg Gin Leu 945 950 955 960 Asn Asp Ser Arg Tyr Ile Ser Arg Val Val Thr Ser Leu Leu Ser Asn 965 970 975 Page 399 of 3790 Leu Val Cys Glu Glu Gly Glu Gin Asp Gly Leu Ser Lys Asn Val Ile 980 985 990 Val Cys Thr Gly Gly Ile Thr Asp Arg Leu Lys Lys Asp Trp Gly Val 995 1000 1005 Gin Glu Val Trp Asn Arg Ile Ile Leu Pro Arg Phe Leu Arg Leu 1010 1015 1020 Asn Glu Ile Thr Gly Arg Thr Asp Phe Thr Ser Thr Ser Val Asn 1025 1030 1035 Gly His Leu Leu Pro Ala Leu Pro Leu Tyr Leu Gin Lys Gly Phe 1040 1045 1050 Asn Lys Lys Arg Ile Asp His Arg His His Ala Met Asp Ala Ile 1055 1060 1065 Val Ile Ala Cys Ala Asn Arg Asn Ile Val Asn Tyr Leu Asn Asn 1070 1075 1080 Ser Ser Ala Arg Lys Asn Ser Glu Ile Ser Arg Tyr Asp Leu Gin 1085 1090 1095 Arg Leu Leu Cys Glu Lys Val Lys Thr Asp Ala Asn Gly Asn Tyr 1100 1105 1110 Lys Trp Ile Leu Arg Lys Pro Trp Glu Thr Phe Thr Gin Asp Val 1115 1120 1125 Tyr Ala Ala Leu Thr Asn Ile Val Val Ser Phe Lys Gin Asn Leu 1130 1135 1140 Arg Val Ile Asn Arg Thr Thr Asn Tyr Tyr Gin His Tyr Asn Glu 1145 1150 1155 Ala Gly Glu Lys Arg Met Ile Pro Gin Thr Lys Gly Asp Arg Trp 1160 1165 1170 Ala Ile Arg Lys Pro Met His Lys Asp Thr Val Tyr Gly Glu Val 1175 1180 1185 Asn Leu Arg Lys Glu Lys Thr Leu Pro Leu Arg Asp Val Val Lys 1190 1195 1200 Asn Pro Ser Ile Val Val Asp Lys Ser Leu Lys Asn Lys Leu Tyr Page 401 of 3790 1505 84 1219 PRT Bacteroides cellulosilyticus 84 Met Lys Glu Glu Val Arg Gly Lys Asn Arg Ser Gin Thr Trp Ala Ile 15 10 15 Leu Ala Lys Phe Phe Val Trp Ser Glu Lys Glu Ser Val Trp Asn Glu 20 25 30 Lys Glu Ala Arg Thr Glu Glu Arg Val Lys Glu Tyr Lys Leu Val Gly 35 40 45 Leu Lys Arg Asp Thr Lys Gly Asn Glu Leu Lys Leu Glu Asn Tyr Arg 50 55 60 Trp Arg Val Gin Ala Leu Ser Glu Gin Leu Asn Pro Glu Ile Val Ala 65 70 75 80 Ile Val Leu Gin Glu Ile Asn Gly Gin Ile Ser Ala Ser Ser Gly Tyr 85 90 95 Leu Gly Ala Ile Ser Asp Arg Ser Lys Gin Leu Tyr Phe Asn Arg Gin 100 105 110 Thr Val Gly Gin Tyr Leu Met Ser Glu Leu Glu Lys Asp Pro Asn Val 115 120 125 Ser Leu Arg Asn Arg Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe 130 135 140 Page 403 of 3790 Lys Ile Met Gin Leu Cys Asp Val Glu Lys Glu Tyr Ala Val Glu Leu 405 410 415 Ala Asn Val Ser Phe Gin Glu Asp Tyr Gly Ser Leu Ser Ala Lys Ala 420 425 430 Ile Lys Lys Ile Leu Pro Tyr Leu Lys Glu Gly Asn Gin Tyr Asp Val 435 440 445 Ala Cys Asp Tyr Ala Gly Tyr Arg His Ser Arg Ser Ser Leu Thr Lys 450 455 460 Asp Glu Ile Glu Asn Lys Ile Leu Lys Asp Lys Leu Glu Ile Leu Pro 465 470 475 480 Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gin Met 485 490 495 Val Asn Leu Ile Asn Thr Leu Ile Asp Thr Tyr Gly Lys Pro Asp Glu 500 505 510 Ile Arg Val Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Lys Glu Arg 515 520 525 Glu Glu Leu Thr Lys Ser Ile Ala Arg Asn Thr Arg Glu His Asp Glu 530 535 540 Ile Arg Gin Leu Leu Arg Thr Glu Phe Gly Met Met Asn Val Ser Arg 545 550 555 560 Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu Glu Leu Lys Asp Asn Gly 565 570 575 Tyr Lys Thr Leu Tyr Ser Asn Glu Tyr Ile Pro Arg Glu Lys Ile Phe 580 585 590 Ser Lys Glu Ile Asp Ile Glu His Val Ile Pro Gin Ala Arg Leu Phe 595 600 605 Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu Tyr Arg Ala Ile Asn Ile 610 615 620 Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe Val Lys Glu Lys Tyr Gly 625 630 635 640 Asn Asp Gly Leu Glu Lys Phe Leu Asn Arg Cys Glu Thr Leu Phe Lys 645 650 655 Page 404 of 3790 Asp Lys Arg Thr Lys Leu Arg Lys Leu Lys Met Glu Glu Lys Asp Ile 660 665 670 Pro Glu Gly Phe Ile Asp Arg Asp Leu Arg Asn Thr Gin Tyr Ile Ser 675 680 685 Lys Lys Ala Phe Ala Met Leu Asn Glu Ile Ser Arg Arg Val Val Ala 690 695 700 Thr Thr Gly Ser Ile Thr Asp Lys Leu Arg Glu Asp Trp Gin Leu Val 705 710 715 720 Asp Leu Met Lys Glu Leu Asn Leu Pro Lys Tyr Glu Lys Leu Gly Met 725 730 735 Val Glu Met Phe Glu Asp Lys Asp Gly Arg Lys Ile Lys Lys Ile Thr 740 745 750 Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala Val Asp Ala Leu 755 760 765 Thr Val Ala Phe Thr Lys Asp Val Phe Ile Gin Phe Tyr Asn Asn Lys 770 775 780 Asn Ala Ala Trp Met Pro Ala Ser Lys Glu His Ala Asn Ile Thr Gly 785 790 795 800 Ile Lys Ala Arg Tyr Phe Glu Asn Gly Lys Ala Leu Ala Pro Met Pro 805 810 815 Leu Ala Gin Phe Arg Ala Glu Ala Lys Arg His Leu Glu Asn Leu Leu 820 825 830 Val Ser Ile Lys Ala Lys Asn Lys Val Ile Thr Ser Asn Val Asn Arg 835 840 845 Thr Lys Asn Lys Asn Gly Glu Asn Arg Lys Leu Gin Gin Thr Pro Arg 850 855 860 Gly Gin Leu His Leu Glu Thr Val Tyr Gly Ser His Arg Gin Tyr Ala 865 870 875 880 Thr Lys Ile Glu Lys Val Asn Ala Ala Phe Asp Val Thr Lys Ile Ala 885 890 895 Thr Val Ser Lys Leu Ala Tyr Arg Asn Ala Leu Leu Lys Arg Leu Glu 900 910 Page 405 of 3790 905 Page 406 of 3790 Tyr 85 1329 PRT Catenibacterium mitsuokai 85 Page 407 of 3790 Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Cys Glu Ser Thr Glu Lys 130 135 140 Ala Asp Pro Arg Leu Ile Tyr Leu Ala Leu His His Ile Val Lys Tyr 145 150 155 160 Arg Gly Asn Phe Leu Tyr Glu Gly Gin Lys Phe Asn Met Asp Ala Ser 165 170 175 Asn Ile Glu Asp Lys Leu Ser Asp Ile Phe Thr Gin Phe Thr Ser Phe 180 185 190 Asn Asn Ile Pro Tyr Glu Asp Asp Glu Lys Lys Asn Leu Glu Ile Leu 195 200 205 Glu Ile Leu Lys Lys Pro Leu Ser Lys Lys Ala Lys Val Asp Glu Val 210 215 220 Met Thr Leu Ile Ala Pro Glu Lys Asp Tyr Lys Ser Ala Phe Lys Glu 225 230 235 240 Leu Val Thr Gly Ile Ala Gly Asn Lys Met Asn Val Thr Lys Met Ile 245 250 255 Leu Cys Glu Pro Ile Lys Gin Gly Asp Ser Glu Ile Lys Leu Lys Phe 260 265 270 Ser Asp Ser Asn Tyr Asp Asp Gin Phe Ser Glu Val Glu Lys Asp Leu 275 280 285 Gly Glu Tyr Val Glu Phe Val Asp Ala Leu His Asn Val Tyr Ser Trp 290 295 300 Val Glu Leu Gin Thr Ile Met Gly Ala Thr His Thr Asp Asn Ala Ser 305 310 315 320 Ile Ser Glu Ala Met Val Ser Arg Tyr Asn Lys His His Asp Asp Leu 325 330 335 Lys Leu Leu Lys Asp Cys Ile Lys Asn Asn Val Pro Asn Lys Tyr Phe 340 345 350 Asp Met Phe Arg Asn Asp Ser Glu Lys Ser Lys Gly Tyr Tyr Asn Tyr 355 360 365 Ile Asn Arg Pro Ser Lys Ala Pro Val Asp Glu Phe Tyr Lys Tyr Val 370 375 380 Page 408 of 3790 Lys Lys Cys Ile Glu Lys Val Asp Thr Pro Glu Ala Lys Gin Ile Leu 385 390 395 400 Asn Asp Ile Glu Leu Glu Asn Phe Leu Leu Lys Gin Asn Ser Arg Thr 405 410 415 Asn Gly Ser Val Pro Tyr Gin Met Gin Leu Asp Glu Met Ile Lys Ile 420 425 430 Ile Asp Asn Gin Ala Glu Tyr Tyr Pro Ile Leu Lys Glu Lys Arg Glu 435 440 445 Gin Leu Leu Ser Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Phe Gly Pro 450 455 460 Leu Asn Glu Thr Ser Glu His Ala Trp Ile Lys Arg Leu Glu Gly Lys 465 470 475 480 Glu Asn Gin Arg Ile Leu Pro Trp Asn Tyr Gin Asp Ile Val Asp Val 485 490 495 Asp Ala Thr Ala Glu Gly Phe Ile Lys Arg Met Arg Ser Tyr Cys Thr 500 505 510 Tyr Phe Pro Asp Glu Glu Val Leu Pro Lys Asn Ser Leu Ile Val Ser 515 520 525 Lys Tyr Glu Val Tyr Asn Glu Leu Asn Lys Ile Arg Val Asp Asp Lys 530 535 540 Leu Leu Glu Val Asp Val Lys Asn Asp Ile Tyr Asn Glu Leu Phe Met 545 550 555 560 Lys Asn Lys Thr Val Thr Glu Lys Lys Leu Lys Asn Trp Leu Val Asn 565 570 575 Asn Gin Cys Cys Ser Lys Asp Ala Glu Ile Lys Gly Phe Gin Lys Glu 580 585 590 Asn Gin Phe Ser Thr Ser Leu Thr Pro Trp Ile Asp Phe Thr Asn Ile 595 600 605 Phe Gly Lys Ile Asp Gin Ser Asn Phe Asp Leu Ile Glu Asn Ile Ile 610 615 620 Tyr Asp Leu Thr Val Phe Glu Asp Lys Lys Ile Met Lys Arg Arg Leu 625 630 635 640 Page 409 of 3790 Lys Lys Lys Tyr Ala Leu Pro Asp Asp Lys Val Lys Gin Ile Leu Lys 645 650 655 Leu Lys Tyr Lys Asp Trp Ser Arg Leu Ser Lys Lys Leu Leu Asp Gly 660 665 670 Ile Val Ala Asp Asn Arg Phe Gly Ser Ser Val Thr Val Leu Asp Val 675 680 685 Leu Glu Met Ser Arg Leu Asn Leu Met Glu Ile Ile Asn Asp Lys Asp 690 695 700 Leu Gly Tyr Ala Gin Met Ile Glu Glu Ala Thr Ser Cys Pro Glu Asp 705 710 715 720 Gly Lys Phe Thr Tyr Glu Glu Val Glu Arg Leu Ala Gly Ser Pro Ala 725 730 735 Leu Lys Arg Gly Ile Trp Gin Ser Leu Gin Ile Val Glu Glu Ile Thr 740 745 750 Lys Val Met Lys Cys Arg Pro Lys Tyr Ile Tyr Ile Glu Phe Glu Arg 755 760 765 Ser Glu Glu Ala Lys Glu Arg Thr Glu Ser Lys Ile Lys Lys Leu Glu 770 775 780 Asn Val Tyr Lys Asp Leu Asp Glu Gin Thr Lys Lys Glu Tyr Lys Ser 785 790 795 800 Val Leu Glu Glu Leu Lys Gly Phe Asp Asn Thr Lys Lys Ile Ser Ser 805 810 815 Asp Ser Leu Phe Leu Tyr Phe Thr Gin Leu Gly Lys Cys Met Tyr Ser 820 825 830 Gly Lys Lys Leu Asp Ile Asp Ser Leu Asp Lys Tyr Gin Ile Asp His 835 840 845 Ile Val Pro Gin Ser Leu Val Lys Asp Asp Ser Phe Asp Asn Arg Val 850 855 860 Leu Val Val Pro Ser Glu Asn Gin Arg Lys Leu Asp Asp Leu Val Val 865 870 875 880 Pro Phe Asp Ile Arg Asp Lys Met Tyr Arg Phe Trp Lys Leu Leu Phe 885 895 Page 410 of 3790 890 Gin Tyr Thr Ile Val Ala Ile Glu Gly Gin Lys Lys Lys Gly Lys 1115 1120 1125 Page 411 of 3790 Thr Lys Lys 1325 Tyr Lys Leu 86 1152 PRT Roseburia inulinivorans 86 Page 412 of 3790 Met Asn Ala Glu His Gly Lys Glu Gly Leu Leu Ile Met Glu Glu Asn 15 10 15 Phe Gin Tyr Arg Ile Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 20 25 30 Ala Val Leu Gin Asn Asn Ser Gin Asp Glu Pro Val Arg Ile Thr Asp 35 40 45 Leu Gly Val Arg Ile Phe Asp Val Ala Glu Asn Pro Lys Asn Gly Asp 50 55 60 Ala Leu Ala Ala Pro Arg Arg Asp Ala Arg Thr Thr Arg Arg Arg Leu 65 70 75 80 Arg Arg Arg Arg His Arg Leu Glu Arg Ile Lys Phe Leu Leu Gin Glu 85 90 95 Asn Gly Leu Ile Glu Met Asp Ser Phe Met Glu Arg Tyr Tyr Lys Gly 100 105 110 Asn Leu Pro Asp Val Tyr Gin Leu Arg Tyr Glu Gly Leu Asp Arg Lys 115 120 125 Leu Lys Asp Glu Glu Leu Ala Gin Val Leu Ile His Ile Ala Lys His 130 135 140 Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Lys Glu Lys Glu Gly 145 150 155 160 Gly Ala Val Leu Lys Ala Thr Thr Glu Asn Gin Lys Ile Met Gin Glu 165 170 175 Lys Gly Tyr Arg Thr Val Gly Glu Met Leu Tyr Leu Asp Glu Ala Phe 180 185 190 His Thr Glu Cys Leu Trp Asn Glu Lys Gly Tyr Val Leu Thr Pro Arg 195 200 205 Asn Arg Pro Asp Asp Tyr Lys His Thr Ile Leu Arg Ser Met Leu Val 210 215 220 Glu Glu Val His Ala Ile Phe Ala Ala Gin Arg Ala His Gly Asn Gin 225 230 235 240 Lys Ala Thr Glu Gly Leu Glu Glu Ala Tyr Val Glu Ile Met Thr Ser 245 250 255 Page 413 of 3790 Gin Arg Ser Phe Asp Met Gly Pro Gly Leu Gin Pro Asp Gly Lys Pro 260 265 270 Ser Pro Tyr Ala Met Glu Gly Phe Gly Asp Arg Val Gly Lys Cys Thr 275 280 285 Phe Glu Lys Asp Glu Tyr Arg Ala Pro Lys Ala Thr Tyr Thr Ala Glu 290 295 300 Leu Phe Val Ala Leu Gin Lys Ile Asn His Thr Lys Leu Ile Asp Glu 305 310 315 320 Phe Gly Thr Gly Arg Phe Phe Ser Glu Glu Glu Arg Lys Thr Ile Ile 325 330 335 Gly Leu Leu Leu Ser Ser Lys Glu Leu Lys Tyr Gly Thr Ile Arg Lys 340 345 350 Lys Leu Asn Ile Asp Pro Ser Leu Lys Phe Asn Ser Leu Asn Tyr Ser 355 360 365 Ala Lys Lys Glu Gly Glu Thr Glu Glu Glu Arg Val Leu Asp Thr Glu 370 375 380 Lys Ala Lys Phe Ala Ser Met Phe Trp Thr Tyr Glu Tyr Ser Lys Cys 385 390 395 400 Leu Lys Asp Arg Thr Glu Glu Met Pro Val Gly Glu Lys Ala Asp Leu 405 410 415 Phe Asp Arg Ile Gly Glu Ile Leu Thr Ala Tyr Lys Asn Asp Asp Ser 420 425 430 Arg Ser Ser Arg Leu Lys Glu Leu Gly Leu Ser Gly Glu Glu Ile Asp 435 440 445 Gly Leu Leu Asp Leu Ser Pro Ala Lys Tyr Gin Arg Val Ser Leu Lys 450 455 460 Ala Met Arg Lys Met Gin Pro Tyr Leu Glu Asp Gly Leu Ile Tyr Asp 465 470 475 480 Lys Ala Cys Glu Ala Ala Gly Tyr Asp Phe Arg Ala Leu Asn Asp Gly 485 490 495 Asn Lys Lys His Leu Leu Lys Gly Glu Glu Ile Asn Ala Ile Val Asn 500 505 510 Page 414 of 3790 Asp Ile Thr Asn Pro Val Val Lys Arg Ser Val Ser Gin Thr Ile Lys 515 520 525 Val Ile Asn Ala Ile Ile Gin Lys Tyr Gly Ser Pro Gin Ala Val Asn 530 535 540 Ile Glu Leu Ala Arg Glu Met Ser Lys Asn Phe Gin Asp Arg Thr Asn 545 550 555 560 Leu Glu Lys Glu Met Lys Lys Arg Gin Gin Glu Asn Glu Arg Ala Lys 565 570 575 Gin Gin Ile Ile Glu Leu Gly Lys Gin Asn Pro Thr Gly Gin Asp Ile 580 585 590 Leu Lys Tyr Arg Leu Trp Asn Asp Gin Gly Gly Tyr Cys Leu Tyr Ser 595 600 605 Gly Lys Lys Ile Pro Leu Glu Glu Leu Phe Asp Gly Gly Tyr Asp Ile 610 615 620 Asp His Ile Leu Pro Tyr Ser Ile Thr Phe Asp Asp Ser Tyr Arg Asn 625 630 635 640 Lys Val Leu Val Thr Ala Gin Glu Asn Arg Gin Lys Gly Asn Arg Thr 645 650 655 Pro Tyr Glu Tyr Phe Gly Ala Asp Glu Lys Arg Trp Glu Asp Tyr Glu 660 665 670 Ala Ser Val Arg Leu Leu Val Arg Asp Tyr Lys Lys Gin Gin Lys Leu 675 680 685 Leu Lys Lys Asn Phe Thr Glu Glu Glu Arg Lys Glu Phe Lys Glu Arg 690 695 700 Asn Leu Asn Asp Thr Lys Tyr Ile Thr Arg Val Val Tyr Asn Met Ile 705 710 715 720 Arg Gin Asn Leu Glu Leu Glu Pro Phe Asn His Pro Glu Lys Lys Lys 725 730 735 Gin Val Trp Ala Val Asn Gly Ala Val Thr Ser Tyr Leu Arg Lys Arg 740 745 750 Trp Gly Leu Met Gin Lys Asp Arg Ser Thr Asp Arg His His Ala Met Page 415 of 3790 Page 416 of 3790 87 686 PRT Coprococcus comes 87 Met Lys Lys Gin Asp Ser Pro Lys Asn Asn Met Gly Tyr Thr Ala Tyr 15 10 15 Asn Leu Asn Val Leu Gly Tyr Glu Glu Phe Ala Lys Arg Val 20 25 30 Glu Leu Leu Phe Lys Asp 35 Thr Asp Ala Val Lys Arg Leu Asn Asp 45 Ser His Met Gin Met Ala Glu Gly Phe Asp Leu Asn Ala Leu Pro Gly Ser Pro Ala 50 55 60 Page 417 of 3790 Leu Arg Arg Gly Val Ser Gin Ala Ile Lys Val Leu Asp Asp Ile Val 65 70 75 80 Ser Val Ala Gly Lys Ala Pro Asp Arg Ile Tyr Leu Lys Val Thr Arg 85 90 95 Thr Ala Ser Asn Ser Arg Lys Gly Lys Arg Thr Ala Lys Arg Ser Asp 100 105 110 Lys Ile Lys Gin Ala Leu Lys Ala Leu Asp Ala Asp Ala Ala Ala Asp 115 120 125 Leu Gly Ala Ala Lys Leu Leu Arg Glu Leu Gly Met Phe Asp Glu Lys 130 135 140 Glu Ile Asn Glu Arg Ile Tyr Leu Tyr Phe His Gin Ala Gly Lys Cys 145 150 155 160 Leu Tyr Thr Gly Lys Pro Ile Asp Ile Thr Arg Ile Ala Ser Asn Asp 165 170 175 Tyr Tyr Val Asp His Val Val Pro Leu Ala Tyr Arg Lys Asp Glu Ser 180 185 190 Leu Asp Asn Lys Val Leu Val Tyr Ala Glu Ala Ser Arg Tyr Lys Ser 195 200 205 Glu Thr Leu Leu Val Ser Pro Ala Val Gin Arg Lys Met Leu Pro Phe 210 215 220 Trp Arg Met Leu Arg Asn Ala Gly Leu Met Ser Glu Arg Lys Leu Asn 225 230 235 240 Ala Leu Ile Arg Thr Glu Ile Ser Glu Gly Met Leu Lys Ser Ile Ile 245 250 255 Gly Arg Gin Phe Thr Glu Asn Ser Trp Glu Ala Lys Leu Phe Thr Ala 260 265 270 Ala Ile Ala Ala Lys Tyr Pro Gly Thr Val Val Ile Pro Val Lys Ala 275 280 285 Gly Val Ile Gly Ala Val Arg Ser Arg Ile Gly Ile Pro Lys Ser Leu 290 295 300 Lys Ala Asn Gin Phe Tyr His Ala His Asp Ala Leu Leu Ala Ala Glu 305 310 315 320 Page 418 of 3790 Val Gly Arg Tyr Met Glu Leu Ala Lys Pro Ala Phe Val His Asn Arg 325 330 335 Val Lys Tyr Glu Gin Tyr Met Arg Lys Ile Lys Leu Val Asn Glu Glu 340 345 350 Asn Lys Lys Ala Pro Lys Ser Gin Leu Asp Phe Phe Ala Gly Gly Phe 355 360 365 Phe Phe Asp Arg Val Asp Lys Asp Thr Gly Glu Val Tyr Trp Asn Lys 370 375 380 Asp Glu Glu Val Glu Arg Ile Tyr Arg Ala Cys Gly Trp Lys Asn Leu 385 390 395 400 Arg Val Thr Tyr Ala Ala Phe Glu Asp Gly Gly Ala Phe Trp Lys Gin 405 410 415 Thr Ile Tyr Ser Pro Arg Glu Lys Ser Lys Leu Ile Ala Thr Lys Ser 420 425 430 Asp Arg Pro Ala Glu Ile Tyr Gly Gly Tyr Ser Ser Gin Thr Phe Ala 435 440 445 Asn Phe Phe Val Tyr Glu Val Met Lys Lys Lys Val Lys Gin Leu Arg 450 455 460 Phe Gly Ala Val Pro Ala Ala Ile Ala Ser Lys Ser Asp Pro Asp Thr 465 470 475 480 Tyr Asn Ala Met Leu Glu Met Tyr Ala Arg Gly Leu Ala Lys Thr Ala 485 490 495 Lys Glu Lys Phe Val Arg Ile Val Arg Ala Arg Val Leu Lys Asn Thr 500 505 510 Met Ile Glu Leu Tyr Gly Glu Arg Phe Arg Ile Ala Gly Glu Lys Gin 515 520 525 Val Tyr Pro Val Arg Gin Met Pro Leu Ala Ile Asp Glu Val Tyr Leu 530 535 540 Leu Lys Gly Val Glu Thr Ile Ala Ala Ala Gly Asn Ala Gly Ala Ser 545 550 555 560 Ala Lys Ile Asp Phe Glu Lys Ala Ala Glu Ser Leu Val Gly Phe Trp 565 570 575 Page 419 of 3790 675 680 685 88 1105 PRT Actinomyces coleocanis Page 420 of 3790 Thr Pro Ile Arg Asp Glu Asn Asp Leu His Glu Lys Leu Ala Ile Ala 115 120 125 Val Arg His Ile Ala Arg His Arg Gly Trp Arg Ser Pro Trp Val Pro 130 135 140 Val Arg Ser Leu His Val Glu Gin Pro Pro Ser Asp Gin Tyr Leu Ala 145 150 155 160 Leu Lys Glu Arg Val Glu Ala Lys Thr Leu Leu Gin Met Pro Glu Gly 165 170 175 Ala Thr Pro Ala Glu Met Val Val Ala Leu Asp Leu Ser Val Asp Val 180 185 190 Asn Leu Arg Pro Lys Asn Arg Glu Lys Thr Asp Thr Arg Pro Glu Asn 195 200 205 Lys Lys Pro Gly Phe Leu Gly Gly Lys Leu Met Gin Ser Asp Asn Ala 210 215 220 Asn Glu Leu Arg Lys Ile Ala Lys Ile Gin Gly Leu Asp Asp Ala Leu 225 230 235 240 Leu Arg Glu Leu Ile Glu Leu Val Phe Ala Ala Asp Ser Pro Lys Gly 245 250 255 Ala Ser Gly Glu Leu Val Gly Tyr Asp Val Leu Pro Gly Gin His Gly 260 265 270 Lys Arg Arg Ala Glu Lys Ala His Pro Ala Phe Gin Arg Tyr Arg Ile 275 280 285 Ala Ser Ile Val Ser Asn Leu Arg Ile Arg His Leu Gly Ser Gly Ala 290 295 300 Asp Glu Arg Leu Asp Val Glu Thr Gin Lys Arg Val Phe Glu Tyr Leu 305 310 315 320 Leu Asn Ala Lys Pro Thr Ala Asp Ile Thr Trp Ser Asp Val Ala Glu 325 330 335 Glu Ile Gly Val Glu Arg Asn Leu Leu Met Gly Thr Ala Thr Gin Thr 340 345 350 Ala Asp Gly Glu Arg Ala Ser Ala Lys Pro Pro Val Asp Val Thr Asn Page 421 of 3790 355 360 365 Val Ala Phe Ala Thr Cys Lys Ile Lys Pro Leu Lys Glu Trp Trp Leu 370 375 380 Asn Ala Asp Tyr Glu Ala Arg Cys Val Met Val Ser Ala Leu Ser His 385 390 395 400 Ala Glu Lys Leu Thr Glu Gly Thr Ala Ala Glu Val Glu Val Ala Glu 405 410 415 Phe Leu Gin Asn Leu Ser Asp Glu Asp Asn Glu Lys Leu Asp Ser Phe 420 425 430 Ser Leu Pro Ile Gly Arg Ala Ala Tyr Ser Val Asp Ser Leu Glu Arg 435 440 445 Leu Thr Lys Arg Met Ile Glu Asn Gly Glu Asp Leu Phe Glu Ala Arg 450 455 460 Val Asn Glu Phe Gly Val Ser Glu Asp Trp Arg Pro Pro Ala Glu Pro 465 470 475 480 Ile Gly Ala Arg Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala 485 490 495 Val Asn Arg Tyr Leu Met Ala Ala Glu Ala Glu Trp Gly Ala Pro Leu 500 505 510 Ser Val Asn Ile Glu His Val Arg Glu Gly Phe Ile Ser Lys Arg Gin 515 520 525 Ala Val Glu Ile Asp Arg Glu Asn Gin Lys Arg Tyr Gin Arg Asn Gin 530 535 540 Ala Val Arg Ser Gin Ile Ala Asp His Ile Asn Ala Thr Ser Gly Val 545 550 555 560 Arg Gly Ser Asp Val Thr Arg Tyr Leu Ala Ile Gin Arg Gin Asn Gly 565 570 575 Glu Cys Leu Tyr Cys Gly Thr Ala Ile Thr Phe Val Asn Ser Glu Met 580 585 590 Asp His Ile Val Pro Arg Ala Gly Leu Gly Ser Thr Asn Thr Arg Asp 595 600 605 Page 422 of 3790 Asn Leu Val Ala Thr Cys Glu Arg Cys Asn Lys Ser Lys Ser Asn Lys 610 615 620 Pro Phe Ala Val Trp Ala Ala Glu Cys Gly Ile Pro Gly Val Ser Val 625 630 635 640 Ala Glu Ala Leu Lys Arg Val Asp Phe Trp Ile Ala Asp Gly Phe Ala 645 650 655 Ser Ser Lys Glu His Arg Glu Leu Gin Lys Gly Val Lys Asp Arg Leu 660 665 670 Lys Arg Lys Val Ser Asp Pro Glu Ile Asp Asn Arg Ser Met Glu Ser 675 680 685 Val Ala Trp Met Ala Arg Glu Leu Ala His Arg Val Gin Tyr Tyr Phe 690 695 700 Asp Glu Lys His Thr Gly Thr Lys Val Arg Val Phe Arg Gly Ser Leu 705 710 715 720 Thr Ser Ala Ala Arg Lys Ala Ser Gly Phe Glu Ser Arg Val Asn Phe 725 730 735 Ile Gly Gly Asn Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 740 745 750 Asp Ala Ala Thr Val Ala Met Leu Arg Asn Ser Val Ala Lys Thr Leu 755 760 765 Val Leu Arg Gly Asn Ile Arg Ala Ser Glu Arg Ala Ile Gly Ala Ala 770 775 780 Glu Thr Trp Lys Ser Phe Arg Gly Glu Asn Val Ala Asp Arg Gin Ile 785 790 795 800 Phe Glu Ser Trp Ser Glu Asn Met Arg Val Leu Val Glu Lys Phe Asn 805 810 815 Leu Ala Leu Tyr Asn Asp Glu Val Ser Ile Phe Ser Ser Leu Arg Leu 820 825 830 Gin Leu Gly Asn Gly Lys Ala His Asp Asp Thr Ile Thr Lys Leu Gin 835 840 845 Met His Lys Val Gly Asp Ala Trp Ser Leu Thr Glu Ile Asp Arg Ala 850 855 860 Page 423 of 3790 Leu Pro Val Ser Trp Gin Gly 1100 1105 Page 424 of 3790 Asp Ile Gly Thr Asn Ser Val Gly 10 15 Asn Ile Glu Arg Phe Lys Lys Lys 25 30 Asp Glu Ala Lys Thr Ala Glu Ser 45 Arg Met Arg Gin Arg Lys Ile Gin 60 Phe Asp Val Glu Ile Ser Lys Val 75 80 Lys Glu Ser Asp Leu His Tyr Glu 90 95 Ala Leu Phe Asn Asp Lys Glu Phe 105 110 Tyr Pro Thr Ile Phe His Leu Ile 125 Lys Lys Asp Ile Arg Leu Leu Tyr 140 Asn Arg Gly His Phe Ile Phe Glu 155 160 Ser Leu Asn Asn Asn Ile Asn Lys 170 175 Tyr Asn Ile Cys Leu Asp Phe Asp 185 190 Val Asn Gin Asn Leu Asn Ile Ser 205 Leu Leu Arg Lys Thr Asn Leu Glu 220 Page 425 of 3790 Val Gly Ile Ala Asn Leu Ile Ala Gly Gly Ser Ile Lys Leu Ser Asn 225 230 235 240 Met Phe Asp Asp Asp Glu Leu Lys Asn Leu Asp Tyr Asn Ser Leu Ser 245 250 255 Phe Lys Asn Ser Asn Phe Asp Glu Gly Arg Glu Leu Phe Glu Glu Val 260 265 270 Leu Glu Asp Arg Phe Glu Leu Val Glu Ile Leu Lys Asp Ile His Asp 275 280 285 Ala Ser Val Leu Glu Thr Met Leu Ser Ser Ala Ser Ile Ser Pro Asp 290 295 300 Gly Gly Lys Tyr Ile Ser Ser Ser Met Ile Asn Ser Tyr Asn Lys His 305 310 315 320 Lys Arg Asp Leu Lys Leu Leu Lys Lys Ile Ile Lys Lys Tyr Lys Lys 325 330 335 Ser Glu Tyr Asp Asn Ile Phe Arg Asp Glu Asn Ile Lys Asn Asn Tyr 340 345 350 Leu Ser Tyr Thr Arg Thr Gly Ile Asn Lys Asn Lys Lys Val Gin Ala 355 360 365 Glu Asp Asn Thr Asp Ser Asp Gly Phe Tyr Lys Tyr Ile Val Lys Ile 370 375 380 Leu Lys Asp Ile Lys Glu Asn Asp Ser Asp Glu Asp Ile Lys Tyr Ile 385 390 395 400 Leu Ser Glu Ile Asp Lys Lys Asn Phe Val Pro Lys Gin Arg Thr Lys 405 410 415 Glu Asn Ser Val Ile Pro Tyr Gin Leu Arg Glu Ile Glu Leu Arg Lys 420 425 430 Ile Ile Asp Asn Gin Ser Lys Tyr His Lys Phe Leu Asn Glu Val Asp 435 440 445 Glu Lys Gly Ile Ser Val Lys Glu Lys Ile Ile Ser Leu Leu Thr Phe 450 455 460 Arg Ile Pro Tyr Tyr Ile Gly Pro Leu Asn Pro Ser Tyr Asn Glu Glu Page 427 of 3790 Phe Lys Asp Glu Ile Glu Lys Leu Asn Ser Lys Tyr Tyr Thr Asp Glu 725 730 735 Lys Ile Asn Ile Asp Tyr Leu Asp Asp Leu Tyr Leu Ser Ser Pro Ala 740 745 750 Lys Arg Met Leu Trp Gin Ser Phe Gin Ile Val Asp Glu Ile Lys Asn 755 760 765 Ile Lys Asn Ser Asp Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Ser 770 775 780 Lys Glu Asp Lys Pro Thr Arg Lys Met Ser Arg Lys Ser Arg Leu Glu 785 790 795 800 Lys Leu Tyr Thr Asp Ser Lys Lys Gin Phe Ile Lys Leu Phe Gly Pro 805 810 815 Asp Glu Tyr Asp Lys Leu Asn Asn Glu Ile Lys Asn Lys Ser Glu Ser 820 825 830 Asp Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gin Phe Gly Arg 835 840 845 Cys Met Tyr Ser Leu Asp Pro Ile Asp Leu Glu Glu Leu Ser Asn Lys 850 855 860 Asn Leu Tyr Asp Gin Asp His Ile Tyr Pro Lys Ser Lys Ile Tyr Asp 865 870 875 880 Asp Ser Ile Glu Asn Arg Val Leu Val Lys Lys Gin Leu Asn Leu Asp 885 890 895 Lys Ser Asn Glu Tyr Pro Ile Pro Asp Arg Val Leu Asn Lys Asp Lys 900 905 910 Asn Lys Leu Leu Ala Phe Trp Lys Met Leu Asn Glu Lys Glu Leu Ile 915 920 925 Gly Asp Lys Lys Tyr Ala Arg Leu Ile Arg Lys Ser Pro Phe Thr Asp 930 935 940 Glu Glu Leu Gly Asp Phe Ile Ala Arg Gin Leu Val Glu Thr Arg Gin 945 950 955 960 Ala Thr Lys Glu Thr Ala Asn Met Leu Lys Arg Leu Cys Pro Asp Ser 965 970 975 Page 428 of 3790 Lys Ile Val Tyr Val Lys Ala Lys Asn Val Ser Asp Phe Arg Arg Lys 980 985 990 Phe Asp Ile Leu Lys Cys Arg Ser Ile Asn Asp Leu His His Ala His 995 1000 1005 Asp Ala Tyr Leu Asn Ile Val Val Gly Asn Val Phe Asp Thr Lys 1010 1015 1020 Phe Thr Ser Asn Pro Leu Asn Phe Ile Lys Asn Asn Ser Lys Asn 1025 1030 1035 Arg Ser Tyr Asn Leu Glu Lys Ile Tyr Asp Tyr Asp Val Ile Arg 1040 1045 1050 Asn Glu Lys Ile Ala Trp Leu Ala Glu Arg Lys Glu Glu Asn Gin 1055 1060 1065 Asp Gly Ser Ile Ala Thr Val Leu Lys Asn Leu Ser Lys Asn Asp 1070 1075 1080 Ile Arg Val Thr Arg Arg Thr Tyr Ile Lys Cys Glu Asp Leu Phe 1085 1090 1095 Asp Glu Asn Ile Val Arg Lys Gly Asn Gly Lys Phe Pro Ile Lys 1100 1105 1110 Glu Asn Asn Asn Lys Ser Asp Thr Asn Lys Tyr Gly Gly Tyr Ser 1115 1120 1125 Gly Ile Lys Asn Ala Tyr Phe Val Leu Leu Glu Asp Glu Lys His 1130 1135 1140 Asn Arg Ile Leu Glu Ala Ile Pro Ser Phe Ile Tyr Lys Lys Glu 1145 1150 1155 Lys Asn Gly Glu Lys Gly Ser Val Ile Asn Tyr Leu Gin Asn Ile 1160 1165 1170 Leu Gly Ile Lys Ser Ala Lys Ile Leu Arg Asp Lys Ile Lys Ile 1175 1180 1185 Gly Ser Leu Leu Lys Ile Asp Lys Phe Pro Tyr Asn Leu Ala Gly 1190 1195 1200 Lys Ser Gly Asn Gly Ile Leu Ile Ser Gly Gly Val Gin Leu Ile 1205 1210 1215 Page 429 of 3790 90 1377 PRT Lactobacillus brevis 90 Met Glu Ser Asn His Asp Gly Glu Gin Val Lys Tyr Thr Leu Gly Leu 15 10 15 Asp Ile Gly Thr Ser Ser Ile Gly Tyr Ala Ala Ile Asp Lys His Gin 20 25 30 Lys Pro Ile Arg Ala Lys Gly Lys His Val Ile Gly Val Arg Leu Phe 35 40 45 Gin Glu Gly Gin Thr Ala Ala Asp Arg Arg Ala Phe Arg Thr Thr Arg 50 55 60 Page 430 of 3790 Arg Arg Leu Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Asn Arg Leu 65 70 75 80 Phe Asp Pro Tyr Leu Ser Glu Val Asp Pro Asn Phe Leu Pro Arg Leu 85 90 95 Arg Gin Ser Asn Leu Ser Pro Lys Asp Asp Asn Lys His Phe Asn Gly 100 105 110 Ser Thr Leu Phe Pro Asp Lys Thr Asp Ala Ala Phe Tyr Arg Gin Tyr 115 120 125 Pro Thr Met Tyr His Leu Arg Tyr Ala Leu Met Thr Glu Lys Arg Lys 130 135 140 Phe Asp Ile Arg Glu Val Tyr Leu Ala Ile His His Ile Val Lys Tyr 145 150 155 160 Arg Gly Asn Phe Leu Asn Ser Ala Thr Val Asp Ser Phe Lys Thr Ser 165 170 175 Asn Ile Asp Phe Thr Ser Gin Phe Asp Arg Leu Asn Glu Leu Tyr Arg 180 185 190 Gin Val Ile Leu Asp Glu Pro Phe Gin Ile Asn Met Asp Gin Val Asp 195 200 205 Glu Met Thr Asn Lys Leu Leu Asp Asn Asp Ala Leu Lys Leu Asp Thr 210 215 220 Gin Lys Gin Val Ala Lys Leu Leu Pro Val Ile Tyr Asn Asp Lys Pro 225 230 235 240 Ile Asp Lys Gin Tyr Thr Arg Ile Ala Thr Glu Phe Ser Lys Ala Ile 245 250 255 Leu Gly Tyr Lys Thr Lys Leu Asp Val Ile Leu Asn Leu Asp Thr Gin 260 265 270 Asn Ala Lys Asp Trp Val Ile Arg Leu Asp Asp Glu Asp Ile Asp Asp 275 280 285 Lys Leu Pro Ala Leu Val Glu Asn Leu Asp Glu Ser Arg Gin Glu Ile 290 295 300 Val Thr Ile Ile Arg Asp Leu Tyr Ala Gin Ile Thr Leu Asn Ala Ile Page 432 of 3790 Asn Asp Ser Arg Leu Ser Pro Ser Gin Lys Gin Asp Leu Phe Asn Asn 565 570 575 Leu Phe Lys Lys Gin Lys Thr Ile Arg Thr Lys Lys Leu Gin Thr Tyr 580 585 590 Ile Arg Thr Asn Trp Glu Leu Pro Ser Val Met Ile Ser Gly Leu Ala 595 600 605 Asp Pro Asp Lys Phe Asn Ser Ser Leu Ser Thr Tyr Ile Asp Phe Arg 610 615 620 Asp Ile Phe Gly Glu Lys Val Asp Asp Pro Asn Arg Gin Ala Asp Tyr 625 630 635 640 Glu Glu Ile Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile Tyr 645 650 655 Gin Ala Lys Leu Asn Gin Leu Asp Trp Leu Thr Glu Pro Gin Arg Lys 660 665 670 Ala Leu Leu Thr Lys Arg Tyr Thr Gly Trp Gly Arg Leu Ser Lys Lys 675 680 685 Leu Leu Thr Gly Leu Lys Asp Gin Asn Gly Asp Ser Ile Leu Asp Gin 690 695 700 Leu Trp Lys Thr Asn Asp Asn Phe Met Gin Ile Gin Ser Arg Asp Glu 705 710 715 720 Phe Ala Lys Gin Ile His Asp Glu Asn Ala Lys Gin Phe His Glu Ala 725 730 735 Asn Asn Val Asp Asp Ile Leu Asp Asp Ala Phe Thr Ser Pro Gin Asn 740 745 750 Lys Lys Ala Ile Arg Gin Val Asp Lys Val Val Gin Asp Val Val Lys 755 760 765 Ala Val Gly Tyr Ala Pro Asp Lys Ile Ala Ile Glu Phe Thr Arg Ser 770 775 780 Leu Glu Asn Asn Pro Gin Arg Thr Val Ser Arg Gin Arg Gin Leu Gin 785 790 795 800 Ala Ala Tyr Lys Asn Ile Pro Arg Glu Ile Met Lys Ser Gly Leu Met 805 810 815 Page 433 of 3790 Val Asp Ser Glu Thr Gly Glu Ile Val Trp Glu Lys His Gly Ser 1055 1060 1065 Page 434 of 3790 Phe Val Asn Leu Pro Leu Ser Asn Gin Tyr Asp Gly Ser Lys Leu Page 435 of 3790 1295 1300 1305 1370 1375 91 1239 PRT Lactobacillus buchneri 91 Met Thr Glu Lys Arg Lys Phe Asp Ile Arg Glu Val Tyr Leu Ala Ile 15 10 15 His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn Ser Ala Thr Val 20 25 30 Asp Ser Phe Lys Thr Ser Asn Ile Asp Phe Thr Ser Gin Phe Asp Arg 35 40 45 Leu Asn Glu Leu Tyr Arg Gin Val Ile Leu Glu Glu Pro Phe Gin Ile 50 55 60 Asn Met Asn Gin Val Asp Lys Met Thr Asn Lys Leu Leu Asp Asn Asp 65 70 75 80 Ala Leu Lys Leu Asp Thr Gin Lys Gin Val Ala Lys Leu Leu Pro Val 85 90 95 Ile Tyr Asn Asp Lys Pro Val Asp Lys Gin Tyr Thr Arg Leu Ala Thr 100 105 110 Glu Phe Ser Lys Ala Ile Leu Gly Tyr Lys Thr Lys Leu Asp Val Ile 115 120 125 Leu Asn Leu Asp Thr Gin Asn Ala Lys Asp Trp Ala Ile Arg Leu Asp Page 437 of 3790 Ile Arg Arg Met Thr Thr Lys Asp Ser Tyr Leu Val Ala Glu Asp Val 385 390 395 400 Leu Pro Asp Ser Ser Leu Ile Tyr Glu Lys Phe Lys Val Leu Asn Glu 405 410 415 Leu Asn Met Leu Lys Val Asn Asp Arg Arg Leu Ser Ile Ser Gin Lys 420 425 430 Gin Asp Leu Phe Asn Asn Leu Phe Lys Lys Gin Lys Thr Ile Arg Thr 435 440 445 Lys Lys Leu Gin Thr Tyr Ile Arg Thr Lys Trp Glu Leu Pro Ser Val 450 455 460 Met Ile Ser Gly Leu Ser Asp Pro Asp Lys Phe Asn Ser Ser Leu Ala 465 470 475 480 Thr Tyr Ile Asp Phe Arg Asp Val Phe Gly Glu Lys Val Asp Asp Pro 485 490 495 Asn Arg Gin Ala Asp Tyr Glu Lys Ile Ile Glu Trp Ser Thr Val Phe 500 505 510 Glu Asp Arg Lys Ile Tyr Gin Ala Lys Leu Asn Gin Leu Asp Trp Leu 515 520 525 Thr Glu Ser Gin Ser Lys Ala Leu Leu Thr Lys His Tyr Thr Gly Trp 530 535 540 Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Lys Asp Gin Asn Gly 545 550 555 560 Asp Ser Ile Leu Asp Gin Leu Trp Lys Thr Asn Asp Asn Phe Met Gin 565 570 575 Ile Gin Ser Arg Asp Glu Phe Ala Lys Gin Ile His Asp Glu Asn Ala 580 585 590 Lys Gin Phe His Glu Ala Asn Asn Val Asp Asp Ile Leu Asp Asp Ala 595 600 605 Phe Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg Gin Val Asp Lys Val 610 615 620 Val Gin Asp Val Val Lys Ala Val Gly Tyr Ala Pro Asp Lys Ile Ala 625 630 635 640 Page 438 of 3790 Ile Glu Phe Thr Arg Ser Pro Gin Asp Arg Pro Gin Arg Thr Phe Ser 645 650 655 Arg Gin Arg Gin Leu Gin Ser Thr Tyr Leu Asn Val Ala Lys Ala Leu 660 665 670 Met Lys Ser Asn Leu Asn Gin Glu Leu Lys Ser Val Ile Asp Ser Gin 675 680 685 Gin Thr Leu Thr Asp Lys Leu Tyr Leu Tyr Phe Thr Gin Leu Gly Gin 690 695 700 Asp Met Tyr Thr Gly Lys Glu Ile Asn Phe Asp Glu Leu Val Asn Tyr 705 710 715 720 Gin Ile Asp His Ile Leu Pro Gin Ala Phe Ile Lys Asp Asp Ser Leu 725 730 735 Asp Asn Arg Val Leu Val Ser Ala Pro Ile Asn Asn Ala Lys Ser Asp 740 745 750 Asn Val Pro Val Lys Lys Phe Gly Ala Lys Met Gly Tyr Phe Trp Lys 755 760 765 Gin Leu Ala Glu Asn His Leu Ile Ser Lys Arg Lys Leu Asn Asn Leu 770 775 780 Thr Thr Asp Pro Asp Lys Ile Gly Lys Phe Thr Ala Gin Gly Phe Ile 785 790 795 800 His Arg Gin Leu Val Glu Thr Ser Gin Val Ile Arg Leu Val Ala Asn 805 810 815 Ile Leu Gly Asn Glu Tyr Gly His Asp Gly Thr Thr Ile Ile Glu Val 820 825 830 Thr Ala Lys Met Asn His Gin Met Arg Lys Asp Phe Asp Leu Ile Lys 835 840 845 Ile Arg Asp Val Asn Asp Tyr His His Ala Met Asp Ala Tyr Leu Thr 850 855 860 Ala Tyr Val Gly Asp Tyr Leu Tyr Leu Arg Tyr Pro Lys Leu Arg Ser 865 870 875 880 Tyr Phe Val Tyr Gly Asp Phe Lys Lys Leu Lys Asp Gin Ser Leu Lys 885 890 895 Page 439 of 3790 Ile Leu Glu Lys Val Asp Gin Tyr Phe Glu Leu Tyr Asp Ile Asn 1235 92 1381 PRT Lactobacillus fermentum 92 His Pro Glu Asp Pro Ala Lys Asn Gin Ala Phe Ile Gly Lys Leu Leu Page 442 of 3790 Glu Arg Gin Leu Ala Glu Val Lys Glu Tyr Leu Ala Thr Gin Pro Ala 355 360 365 Ser Ala Arg Lys Glu Phe Asp Gin Val Tyr Asn Lys Tyr Ile Gly Gin 370 375 380 Val Pro Lys Glu Lys Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile 385 390 395 400 Leu Ser Lys Lys Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala 405 410 415 Gly Asp Phe Leu Pro Lys Gin Arg Thr Ser Ala Asn Gly Val Ile Pro 420 425 430 His Gin Met His Gin Gin Glu Leu Asp Arg Ile Ile Glu Lys Gin Ala 435 440 445 Lys Tyr Tyr Pro Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg 450 455 460 Asp Arg His Gin Ala Lys Tyr Glu Leu Asp Gin Leu Val Ser Phe Arg 465 470 475 480 Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Pro Glu Val Gin Lys Ala 485 490 495 Thr Ser Gly Ala Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu 500 505 510 Ile Thr Pro Trp Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala 515 520 525 Glu Ala Phe Ile Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn 530 535 540 Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gin Lys Tyr Asn Val 545 550 555 560 Leu Asn Glu Leu Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val 565 570 575 Gly Ile Lys Gin Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr 580 585 590 Val Lys Ala Gly Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly 595 600 605 Page 443 of 3790 Val Asn Lys Pro Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn 610 615 620 Ser Asn Leu Ala Thr Tyr Leu Asp Leu Lys Ser Ile Met Gly Asp Lys 625 630 635 640 Val Asp Asp Asn Arg Tyr Gin Met Asp Leu Glu Asn Ile Ile Glu Trp 645 650 655 Arg Ser Val Phe Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu 660 665 670 Val Glu Trp Leu Thr Asp Glu Gin Arg Ser Ala Leu Val Lys Lys Arg 675 680 685 Tyr Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val 690 695 700 Asp Glu Asn Gly Gin Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gin 705 710 715 720 Asn Phe Met Gin Ile Val Asn Gin Pro Val Phe Lys Glu Gin Ile Asp 725 730 735 Gin Leu Asn Gin Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu 740 745 750 Arg Val Glu Ser Val Leu Asp Asp Ala Tyr Thr Ser Pro Gin Asn Lys 755 760 765 Lys Ala Ile Trp Gin Val Val Arg Val Val Glu Asp Ile Val Lys Ala 770 775 780 Val Gly Asn Ala Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu 785 790 795 800 Gly Asn Lys Gly Glu Ile Thr Arg Ser Arg Arg Thr Gin Leu Gin Lys 805 810 815 Leu Phe Glu Asp Gin Ala His Glu Leu Val Lys Asp Thr Ser Leu Thr 820 825 830 Glu Glu Leu Glu Lys 835 Ala Pro Asp 840 Leu Ser Asp Arg Tyr 845 Tyr Phe Tyr Phe Thr Gin Gly Gly Lys Asp Met Tyr Thr Gly Asp Pro Ile Asn Phe 850 855 860 Page 444 of 3790 Ser Lys Glu Val His Asp Arg Ser Asp Gin Leu Tyr Gly Ala Thr 93 1306 PRT Sphingobacterium spiritivorum 93 Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Ile Lys Gin Asn Phe Glu Asn Lys Gin Gly Glu Ile Leu Gly 20 25 30 Met Gly Ser Arg Ile Ile Pro Met Gly Ala Glu Leu Ser Lys Phe Glu 35 40 45 Gin Gly Gin Ala Gin Thr Lys Asn Ala Asn Arg Arg Ile Ala Arg Gly 50 55 60 Thr Arg Lys Leu Asn Lys Arg Tyr Lys Gin Arg Arg Asn Lys Leu Ile 65 70 75 80 Tyr Ile Leu Gin Gly Leu Gly Met Leu Pro Asp Gin Ile Lys Leu Val 85 90 95 Asn Gin Phe Ser Asp Pro Asn Lys Leu Asp Lys Ile Ser Ile Leu Pro 100 105 110 Ile Ser Lys Asn Gin Gin Gin Leu Thr Ala Phe Asp Leu Leu Glu Leu 115 120 125 Arg Val 130 Lys Ala Leu Thr Glu Lys 135 Ile Glu Leu Glu Glu Leu Gly Lys 140 Val 145 Ile Tyr Lys Tyr Asn Gin 150 Leu Arg Gly Tyr 155 Ser Gly Gly Asn Ser 160 Glu Pro Glu Lys Glu Glu Asn Asn Glu Asp Glu Ser Glu Glu Asn Glu 165 170 175 Page 447 of 3790 Lys Thr Asn Asp Ser Phe Val Val Phe Ser Lys Val Leu Ser Leu Gly 180 185 190 Leu Pro Glu Glu Ile Thr Phe Lys Gly Lys Lys Leu Ser Lys Arg Lys 195 200 205 Ile Ala Ile Glu Thr Glu Asp Gly Ile Ile Glu Ala Glu Thr Phe Leu 210 215 220 Asp Ser Leu Lys Glu Asn Asp Ser Leu Glu Leu His Val Asn Ile Arg 225 230 235 240 Arg Ala Lys Ser Gly Asp Thr Ile Thr Ile Lys Leu Pro Ser Lys Thr 245 250 255 Ser Trp Arg Lys Lys Met Glu Asn Ile Glu Lys Gin Leu Ala Asp Lys 260 265 270 Ser Lys Glu Leu Gly Arg Glu Tyr Phe Ile Ser Glu Leu Leu Phe Asp 275 280 285 Ile Leu Lys Glu Asn Lys Trp Ala Lys Ile Arg Asn Asn Val Ile Leu 290 295 300 Arg Ser Arg Tyr Glu Ser Glu Phe Asp Ala Val Trp Ser Glu Gin Ser 305 310 315 320 Lys Tyr Tyr Pro Ile Leu Asn His Leu Glu Thr Asp Arg Leu Gin Lys 325 330 335 Ile Leu Glu Phe Ile Phe Pro Gly Gin Lys Glu Ser Gin Glu Lys Leu 340 345 350 Arg Gin Thr Gly Leu Lys Glu Gly Leu Lys Tyr Val Ile Lys Asn Gin 355 360 365 Val Val Phe Tyr Gin Arg Glu Leu Lys Asp Gin Ser Asp Leu Ile Ser 370 375 380 Asn Cys Arg Tyr Glu Pro Thr Glu Lys Val Val Ala Lys Ser His Pro 385 390 395 400 Val Phe Gin Glu Tyr Lys Ile Trp Glu Gin Ile Asn Lys Leu Val Ile 405 410 415 Asn Thr Lys Ile Glu Asn Gly Val Asn Arg Lys Gly Glu Ile Arg Tyr 420 425 430 Page 448 of 3790 Lys Tyr Ile Asp Lys Pro Ile Pro Val Ala Leu Lys Glu Trp Leu Tyr 435 440 445 Glu Glu Leu Gin Ser Lys Lys Glu Val Ser Phe Asn Pro Ile Leu Thr 450 455 460 Lys Leu Lys Lys Glu Phe Lys Leu Arg Glu Asn Val Asp Phe Leu Asn 465 470 475 480 Gly Met Asn Ala Lys Asp Lys Leu Lys Gly Asn Glu Thr Lys Val Ile 485 490 495 Leu Gin Lys Ala Leu Gly Glu Leu Trp Asn Ile Phe Gly Leu Asp Asp 500 505 510 Ser Glu Arg Gin Val Glu Leu Trp Glu Ile Leu Tyr Asn Gly Lys Gly 515 520 525 Asn Glu Tyr Asp Leu Thr Ser Glu Arg Thr Ser Asn Ile Leu Ala Phe 530 535 540 Ile Glu Lys Tyr Ser Pro Asp Leu Glu Asn Lys Asn Asp Val Ala Ile 545 550 555 560 Lys Ile Ser Lys Ile Lys Phe Ser Arg Asn Tyr Ser Asn Leu Ser Leu 565 570 575 Lys Ala Ile Asp Asn Ile Leu Pro Leu Val Arg Ala Gly Lys Phe Phe 580 585 590 Asp Gin Asn Phe Ser Glu Ala Leu Ser His Lys Ile Val Lys Leu Leu 595 600 605 Asn Glu Asn Val Glu Asp Pro Phe Glu Lys Ser Ala Gin Glu Phe Leu 610 615 620 Asp Lys Asn Gin Asp Val Leu Ser Asp Gly Gly Ile Val Asn Ala Ile 625 630 635 640 Ala Thr Ile Leu Val Tyr Asp Lys His Thr Ala Lys Glu Tyr Ser Gly 645 650 655 Asp Glu Leu Ile Lys Glu Phe Thr Gin Ile Ser Arg Leu Lys Gin Gly 660 665 670 Glu Leu Arg Asn Pro Leu Ala Glu Gin Ile Ile Asn Glu Ala Leu Val 675 680 685 Page 449 of 3790 Ile Val Arg Asp Ile Trp Arg Lys Tyr Gly Phe Lys Pro Asp Glu Ile 690 695 700 Arg Val Glu Leu Ala Arg Glu Leu Lys Asn Asn Ala Val Glu Arg Gly 705 710 715 720 Lys Met Tyr Ser Ala Asn Leu Lys Ser Gin Lys His Asn Ala Glu Ile 725 730 735 Arg Asn Lys Leu Ile Glu Leu Lys Gin Glu Ile Ser Ile Ala Asn Ile 740 745 750 Glu Lys Tyr Lys Leu Trp Val Ser Gin Glu Asn Leu Gin Glu Val Tyr 755 760 765 Leu Lys Asn Tyr Asn Asp Pro Ser Lys Ser Glu Ile Glu Lys Leu Lys 770 775 780 Leu Trp Glu Ser Gin Gly His Ile Ser Pro Tyr Thr Gly Gin Pro Ile 785 790 795 800 Ser Leu Ser Glu Leu Phe Asn Arg Glu Arg Tyr Asp Val Asp His Ile 805 810 815 Ile Pro Gin Ser Arg Tyr Phe Asp Asp Ser Leu Ser Asn Lys Val Ile 820 825 830 Cys Glu Lys Ser Ile Asn Asn Glu Lys Gly Asn Arg Thr Ser Met Glu 835 840 845 Tyr Phe Glu Val Gly Ser Val Asn Tyr Arg Ile Phe Thr Lys Asp Gin 850 855 860 Phe Ile Asp His Ala Asn Lys Tyr Phe Ser Gly Lys Lys Arg Lys Asn 865 870 875 880 Leu Leu Ala Thr Ser Ile Pro Glu Asp Pro Ile Gin Arg Gin Ile Lys 885 890 895 Asp Thr Gin Tyr Ile Ser Ile Arg Ile Arg Glu Glu Leu Asn Lys Ile 900 905 910 Val Gly Asn Glu Asn Val Lys Thr Thr Thr Gly Gly Ile Thr Asp Tyr 915 920 925 Leu Arg Asn His Trp Gly Leu Thr Asp Lys Phe Lys Val Leu Leu Lys His Tyr Asp Leu Lys Leu Phe Leu Thr Leu Leu Ile Phe 1295 1300 1305 Gin Arg Val Lys Leu Val Gin Glu Ile Phe Ala Pro Val Ile Ser Pro 65 70 75 80 Page 452 of 3790 Ile Asp Pro Arg Phe Phe Ile Arg Leu His Glu Ser Ala Leu Trp Arg 85 90 95 Asp Asp Val Ala Glu Thr Asp Lys His Ile Phe Phe Asn Asp Pro Thr 100 105 110 Tyr Thr Asp Lys Glu Tyr Tyr Ser Asp Tyr Pro Thr Ile His His Leu 115 120 125 Ile Val Asp Leu Met Glu Ser Ser Glu Lys His Asp Pro Arg Leu Val 130 135 140 Tyr Leu Ala Val Ala Trp Leu Val Ala His Arg Gly His Phe Leu Asn 145 150 155 160 Glu Val Asp Lys Asp Asn Ile Gly Asp Val Leu Ser Phe Asp Ala Phe 165 170 175 Tyr Pro Glu Phe Leu Ala Phe Leu Ser Asp Asn Gly Val Ser Pro Trp 180 185 190 Val Cys Glu Ser Lys Ala Leu Gin Ala Thr Leu Leu Ser Arg Asn Ser 195 200 205 Val Asn Asp Lys Tyr Lys Ala Leu Lys Ser Leu Ile Phe Gly Ser Gin 210 215 220 Lys Pro Glu Asp Asn Phe Asp Ala Asn Ile Ser Glu Asp Gly Leu Ile 225 230 235 240 Gin Leu Leu Ala Gly Lys Lys Val Lys Val Asn Lys Leu Phe Pro Gin 245 250 255 Glu Ser Asn Asp Ala Ser Phe Thr Leu Asn Asp Lys Glu Asp Ala Ile 260 265 270 Glu Glu Ile Leu Gly Thr Leu Thr Pro Asp Glu Cys Glu Trp Ile Ala 275 280 285 His Ile Arg Arg Leu Phe Asp Trp Ala Ile Met Lys His Ala Leu Lys 290 295 300 Asp Gly Arg Thr Ile Ser Glu Ser Lys Val Lys Leu Tyr Glu Gin His 305 310 315 320 His His Asp Leu Thr Gin Leu Lys Tyr Phe Val Lys Thr Tyr Leu Ala 325 330 335 Page 453 of 3790 Lys Glu Tyr Asp Asp Ile Phe Arg Asn Val Asp Ser Glu Thr Thr Lys 340 345 350 Asn Tyr Val Ala Tyr Ser Tyr His Val Lys Glu Val Lys Gly Thr Leu 355 360 365 Pro Lys Asn Lys Ala Thr Gin Glu Glu Phe Cys Lys Tyr Val Leu Gly 370 375 380 Lys Val Lys Asn Ile Glu Cys Ser Glu Ala Asp Lys Val Asp Phe Asp 385 390 395 400 Glu Met Ile Gin Arg Leu Thr Asp Asn Ser Phe Met Pro Lys Gin Val 405 410 415 Ser Gly Glu Asn Arg Val Ile Pro Tyr Gin Leu Tyr Tyr Tyr Glu Leu 420 425 430 Lys Thr Ile Leu Asn Lys Ala Ala Ser Tyr Leu Pro Phe Leu Thr Gin 435 440 445 Cys Gly Lys Asp Ala Ile Ser Asn Gin Asp Lys Leu Leu Ser Ile Met 450 455 460 Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Arg Lys Asp Asn Ser 465 470 475 480 Glu His Ala Trp Leu Glu Arg Lys Ala Gly Lys Ile Tyr Pro Trp Asn 485 490 495 Phe Asn Asp Lys Val Asp Leu Asp Lys Ser Glu Glu Ala Phe Ile Arg 500 505 510 Arg Met Thr Asn Thr Cys Thr Tyr Tyr Pro Gly Glu Asp Val Leu Pro 515 520 525 Leu Asp Ser Leu Ile Tyr Glu Lys Phe Met Ile Leu Asn Glu Ile Asn 530 535 540 Asn Ile Arg Ile Asp Gly Tyr Pro Ile Ser Val Asp Val Lys Gin Gin 545 550 555 560 Val Phe Gly Leu Phe Glu Lys Lys Arg Arg Val Thr Val Lys Asp Ile 565 570 575 Gin Asn Leu Leu Leu Ser Leu Gly Ala Leu Asp Lys His Gly Lys Leu 580 585 590 Page 454 of 3790 Thr Gly Ile Asp Thr Thr Ile His Ser Asn Tyr Asn Thr Tyr His His 595 600 605 Phe Lys Ser Leu Met Glu Arg Gly Val Leu Thr Arg Asp Asp Val Glu 610 615 620 Arg Ile Val Glu Arg Met Thr Tyr Ser Asp Asp Thr Lys Arg Val Arg 625 630 635 640 Leu Trp Leu Asn Asn Asn Tyr Gly Thr Leu Thr Ala Asp Asp Val Lys 645 650 655 His Ile Ser Arg Leu Arg Lys His Asp Phe Gly Arg Leu Ser Lys Met 660 665 670 Phe Leu Thr Gly Leu Lys Gly Val His Lys Glu Thr Gly Glu Arg Ala 675 680 685 Ser Ile Leu Asp Phe Met Trp Asn Thr Asn Asp Asn Leu Met Gin Leu 690 695 700 Leu Ser Glu Cys Tyr Thr Phe Ser Asp Glu Ile Thr Lys Leu Gin Glu 705 710 715 720 Ala Tyr Tyr Ala Lys Ala Gin Leu Ser Leu Asn Asp Phe Leu Asp Ser 725 730 735 Met Tyr Ile Ser Asn Ala Val Lys Arg Pro Ile Tyr Arg Thr Leu Ala 740 745 750 Val Val Asn Asp Ile Arg Lys Ala Cys Gly Thr Ala Pro Lys Arg Ile 755 760 765 Phe Ile Glu Met Ala Arg Asp Gly Glu Ser Lys Lys Lys Arg Ser Val 770 775 780 Thr Arg Arg Glu Gin Ile Lys Asn Leu Tyr Arg Ser Ile Arg Lys Asp 785 790 795 800 Phe Gin Gin Glu Val Asp Phe Leu Glu Lys Ile Leu Glu Asn Lys Ser 805 810 815 Asp Gly Gin Leu Gin Ser Asp Ala Leu Tyr Leu Tyr Phe Ala Gin Leu 820 825 830 Gly Arg Asp Met Tyr Thr Gly Asp Pro Ile Lys Leu Glu His Ile Lys Page 455 of 3790 Gly Leu Phe Asp Ile Gin Pro Leu Lys Ala Ser Thr Gly Leu Val 1070 1075 1080 Page 456 of 3790 Page 457 of 3790 Ala Asp Leu Thr Gly Leu Ser Lys Lys Tyr Ser Asp Ile Arg Leu 1325 1330 1335 Val Glu Gin Ser Ala Ser Gly Leu Phe Val Ser Lys Ser Gin Asn 1340 1345 1350 Leu Leu Glu Tyr Leu 1355 Lys His Thr Gin Val Ala Met Lys Gin Leu Ser Glu Phe Thr Tyr Glu 20 25 30 Asp Leu Glu Asp Ser Tyr Phe Ser Val Pro Val Lys Arg Met Ile Trp 35 40 45 Gin Thr Leu Leu Val Val Arg Glu Ile Glu Lys Val Met Gly Tyr Ala 50 55 60 Pro Lys Arg Ile Phe Val Glu Met Thr Arg Thr Glu Glu Glu Lys Gly 65 70 75 80 Asp Lys Gly Arg Lys Glu Ser Arg Gly Asn Gin Leu Leu Glu Leu Tyr 85 90 95 Lys Ser Ile Lys Asn Thr Asp Ser His Asn Trp Lys Glu Glu Ile Ala 100 105 110 Ala Ala Asp Lys Asp Gly Lys Leu Arg Ser Lys Lys Leu Phe Leu Tyr 115 120 125 Tyr Met Gin Met Gly Arg Asp Met Tyr Thr Gly Glu Glu Ile Asp Leu 130 135 140 Gly Arg Leu Tyr Asp Asp Asn Leu Tyr Asp Ile Asp His Ile Tyr Pro 145 150 155 160 Arg His Tyr Val Lys Asp Asp Ser Ile Met Asn Asn Leu Val Leu Val 165 170 175 Page 458 of 3790 Asn Arg Arg Ala Asn Gin Asp Ile Lys Lys Asp Leu Tyr Pro Ile Pro 180 185 190 Glu Gin Ile Lys Ala Asn Pro Asn Val His Met Leu Trp Asp Ala Leu 195 200 205 His Lys Gin Lys Leu Ile Thr Asp Glu Lys Tyr Ala Arg Leu Thr Ser 210 215 220 Asn Thr Ala Phe Ser Glu Lys Gin Leu Gly Asp Phe Ile Ala Arg Gin 225 230 235 240 Leu Val Glu Thr Gly Gin Gly Thr Lys Gly Val Ala Asp Leu Leu Glu 245 250 255 Gin Leu Phe Lys Asp Thr Val Ile Val Tyr Ala Lys Ala Ser Asn Val 260 265 270 Ser Asp Phe Arg Arg Asp Asn Gly Phe Leu Lys Ser Arg Leu Val Asn 275 280 285 Asp Phe His His Ala Gin Asp Ala Tyr Leu Asn Ile Val Val Gly Asn 290 295 300 Val Tyr Tyr Thr Lys Phe Thr Lys Asn Pro Trp Asn Phe Ile Cys Lys 305 310 315 320 Asp Tyr Glu Lys Asp Lys Glu Lys Asn Arg Tyr Asn Leu Ala Arg Met 325 330 335 Phe Asp Trp Asn Val Val Arg Gly Ser Glu Thr Ala Trp Ile Val Glu 340 345 350 Arg Lys Asp Glu Lys Gly Thr Ile Ser Thr Val Arg Lys Met Met Gin 355 360 365 Lys Asn Thr Pro Leu Leu Thr Arg Met Asn Phe Glu Gin His Gly Ser 370 375 380 Ile Ala Asn Ala Thr Leu Tyr Ser Ala Lys Lys Ala Lys Ser Glu Asn 385 390 395 400 Tyr Leu Pro Leu Lys Thr Ala Asp Glu Lys Met Ser Asp Val Lys Lys 405 410 415 Tyr Gly Gly Tyr Thr Ser Met Ser Ile Ala Tyr Tyr Phe Ile Val His 420 425 430 Page 459 of 3790 His Lys Glu Asp Lys Lys Glu Asn Val Thr Ile Glu Ala Leu Pro Leu 435 440 445 Tyr Cys Lys Asp Lys Val Glu Arg Glu Glu Asn Gly Leu Glu Lys Tyr 450 455 460 Cys Glu Glu Val Leu Gly Tyr Gly Glu Val Asn Ile Ile Arg Arg Lys 465 470 475 480 Leu Lys Ile Gin Ser Leu Leu Glu Phe Asn Gly Tyr Gin Val His Leu 485 490 495 Ser Gly Lys Thr Gly Asn Gin Leu Ile Leu Arg Asn Ala Ile Ser Leu 500 505 510 Cys Leu Ser Thr Lys Trp Ile Thr Tyr Ile Lys Lys Leu Glu Lys Ala 515 520 525 Val Asn Ile Gin Ile Val Glu Glu Val Val Thr Pro Glu Glu Asn Ile 530 535 540 Lys Leu Tyr Asn Leu Leu Ala Asp Lys His Ala Asn Thr Val Tyr Ser 545 550 555 560 Lys Arg Pro Asn Ala Tyr Gly Glu Lys Leu Leu Ala Asp Arg Glu Ile 565 570 575 Phe Val Thr Leu Glu Phe Gly Lys Gin Cys Glu Ala Leu Leu Gin Ile 580 585 590 Leu Ser Leu Thr Lys Ile Gly Ser Thr Glu Ala Asn Leu Leu Leu Ile 595 600 605 Gly Glu Ser Glu His Ser Gly Lys Ile Leu Ile Ser Lys Asn Leu Lys 610 615 620 Ala Ser Asp Arg Pro Ala Val Ile Asn Gin Ser Pro Cys Gly Leu Tyr 625 630 635 640 Glu Lys Lys Glu Trp Ile Phe Asp Lys Ile Val Glu Lys 645 650 96 1436 PRT Capnocytophaga gingivalis Page 460 of 3790 96 Met Lys Tyr Ile Lys Tyr Ile Leu Gly Leu Asp Ile Gly Ser Asn Ser 15 10 15 Ile Gly Trp Ala Leu Ile Gin Leu Asp Leu Leu Gin Lys Thr Lys Arg 20 25 30 Ile Ile Ala Ala Gly Ser Arg Ile Ile Pro Met Asp Gin Lys Val Leu 35 40 45 Ser Asp Phe Gly Lys Gly Ile Thr Ile Ser Pro Thr Ala Gin Arg Thr 50 55 60 Ser Tyr Arg Asn Ala Arg His Cys Arg Glu Arg His Leu Leu Arg Arg 65 70 75 80 Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro Thr His 85 90 95 Tyr Asp Lys Gin Ile Asp Phe Ser Lys Arg Tyr Gly Lys Phe Val Asp 100 105 110 Asn Thr Glu Pro Lys Ile Ala Tyr Asn Glu Gly Lys Phe Leu Phe Met 115 120 125 Asp Ser Phe Gin Glu Met Leu Ser Asp Phe Lys Ser His Gin Pro Asp 130 135 140 Leu Phe Tyr Thr Lys Lys Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp 145 150 155 160 Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gin Lys Ile Ser 165 170 175 Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gin Lys Arg Gly 180 185 190 Tyr Tyr Gin Leu Arg Glu Glu Glu Gly Asn Lys Glu Asn Asp Phe Glu 195 200 205 Ile Ile Ser Ser Lys Ile Ile Ser Val Ile Lys Lys Asp Lys Asp Lys 210 215 220 Lys Tyr Asn Lys Tyr Trp Tyr Asp Ile Ile Leu Glu Asn Gly Leu Val 225 230 235 240 Tyr Gin Ala Ala Phe Tyr Asn Asp Phe Val Tyr Asn Trp Ile Asn Gin Page 462 of 3790 Leu Lys Tyr Phe Leu Asn Gin Thr Tyr Pro Asn Ala Lys Glu Lys Ala 500 505 510 Leu Lys Ser Glu Leu Lys Lys Trp Lys Asp Thr Tyr Arg Trp Asn Tyr 515 520 525 Val Tyr Asp Ile Gly Glu Lys Ser Ser Lys Lys Tyr Pro Met Asn Glu 530 535 540 Thr Arg Tyr Glu Leu Lys Arg His Leu Glu Lys Val Ala Asn Leu Pro 545 550 555 560 Asp Asp Phe Leu Ser Ser Glu Val Glu Tyr Leu Leu Trp His Leu Ile 565 570 575 Tyr Ser Val Lys Asp Lys Val Ala Tyr Glu Lys Gly Leu Lys Lys Phe 580 585 590 Ala Gin Lys His His Leu Asp Lys Asp Ser Phe Val Glu Ser Phe Lys 595 600 605 Lys Phe Asn Pro Tyr Pro Ser Glu Tyr Gly Ser Phe Ser Glu Lys Ala 610 615 620 Ile Arg Lys Leu Leu Pro Leu Met Arg Phe Gly Ala His Trp Asp Phe 625 630 635 640 Asn His Ile Asp Lys Asn Thr Gin Lys Arg Ile Glu Asp Leu Ile Thr 645 650 655 Gly Val Glu Asn Glu Glu Ile Arg Thr Ile Leu Arg Glu Lys Ala Glu 660 665 670 Lys Tyr Gin Leu Glu Lys Glu Thr Asp Phe Gin Asp Leu Pro Leu Trp 675 680 685 Leu Ala Gin Tyr Ile Val Tyr Asn Arg His Ala Glu Ala Ser Ser Leu 690 695 700 Glu Lys Trp Thr Ser Val Asn Asp Leu Glu Thr Tyr Leu Asn Glu Phe 705 710 715 720 Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin Val Val Met Glu 725 730 735 Thr Leu Arg Val Val Arg Asp Ile Trp Gin Gin Tyr Gly Gin Gly Gin 740 745 750 Page 463 of 3790 Page 464 of 3790 Ala Phe Ser Pro Glu Gly Leu Glu Glu Leu Asn Lys Asn Leu Ser Met Asn Tyr Asp Ile Gly Leu Arg Ile Gly Ile Thr Ser Cys Gly Trp Page 467 of 3790 Gin Tyr Phe Ser Leu Leu Gin Lys Ile Asn Lys Leu Lys Val Ser Asp 260 265 270 Asp Asn Thr Leu Arg Lys Leu Ser Lys Glu Glu Arg Asp Ile Val Ile 275 280 285 Glu Leu Ala Phe Lys Lys Lys Asn Val Ser Phe Val Asp Ile Arg Lys 290 295 300 Ala Leu Lys Leu Asn Asp Asn Thr Lys Phe Asn His Leu Thr Tyr Ser 305 310 315 320 His Val Val Glu Thr Lys Lys Val Glu Lys Ala Thr Phe Ile Glu Leu 325 330 335 Lys Gly Tyr His Leu Ile Lys Lys Gin Leu Lys Asp Arg Asn Val Glu 340 345 350 Leu Thr Gin Glu Leu Gin Pro Lys Asp Tyr Asp Ala Ile Ala Ala Ala 355 360 365 Ser Thr Phe Phe Lys Asn Asp Ile Glu Phe Arg Asp Tyr Leu Arg Asn 370 375 380 Gin Tyr Leu Asp Ser Asn Gly Lys Arg Lys Ser Asn Ile Ala Asn Lys 385 390 395 400 Val Phe Glu Asp Lys Val Ile Ala Ala Val Phe Glu Leu Asn Phe Ser 405 410 415 Lys Val Cys His Leu Ser Phe Lys Ser Leu Tyr Lys Leu Ile Pro His 420 425 430 Leu Glu Lys Gly Leu Asp Tyr Lys Glu Ala Ile Leu Cys Ala Gly Tyr 435 440 445 Asn Phe Arg Asp Glu Asn Lys Arg Asp Lys Lys Leu Phe Leu Pro Val 450 455 460 Ile Gin Gin Glu Thr Asn Pro Val Val His Arg Ala Leu Thr Gin Ala 465 470 475 480 Arg Lys Val Ile Asn Ala Ile Ile Arg Glu Tyr Gly Ser Pro Asn Thr 485 490 495 Ile Arg Phe Val Val Ala Asn Asp Leu Ala Lys Thr Tyr Lys Gin Arg 500 505 510 Page 468 of 3790 Lys Glu Leu Glu Ser Thr Leu Lys Lys Asn Arg Ala Glu Asn Glu Lys 515 520 525 Ile Lys Thr Lys Leu Leu Ser Met Gly Ile Ile Asn Pro Thr Gly Met 530 535 540 Asp Ile Val Lys Tyr Lys Leu Trp Tyr Glu Gin Ser Gly Ile Cys Leu 545 550 555 560 Tyr Thr Gly Arg Gin Met Glu Leu Ser Ser Leu Phe Lys Pro Gly Tyr 565 570 575 Ser Ile Val Asn His Ile Ile Pro Tyr Asn Arg Ser Phe Asp Asp Thr 580 585 590 Tyr His Asn Arg Val Leu Thr Leu Thr Glu Thr Lys Tyr Glu Lys Gly 595 600 605 Asn Lys Ile Pro Phe Glu Tyr Phe Gly Ala Glu Glu Thr Cys Trp Asn 610 615 620 Glu Tyr Glu Lys Arg Val Ser Thr Ser Lys Lys Ile His Asp Lys Lys 625 630 635 640 Arg Glu Lys Leu Leu Ile Arg Asn Phe Asp Ile Glu Tyr Glu Asn Glu 645 650 655 Met Ile Ser Asn Asn Val Phe Asp Thr His Tyr Ile Gly Ser Tyr Phe 660 665 670 Glu Lys Tyr Ile Asp Glu His Leu Gin Phe Lys Lys Ser Thr Lys Lys 675 680 685 Gin Lys Val Phe Ser Ile His Gly Asn Met Val Ala His Leu His Ser 690 695 700 Arg Trp Gly Phe Asn Lys Asn Ser Arg Glu Ile Tyr Leu Asn His Ala 705 710 715 720 Val Asp Ala Ala Ile Val Ala Val Leu Thr Asp Gin Leu Ile Arg Asn 725 730 735 Ile Ala Asp Tyr Tyr Arg Arg Asp Asn Ile Leu Glu Gin Lys Gly Ser 740 745 750 Leu Lys Phe Pro Glu Pro Trp Lys Ser Phe Ser Ile Glu Leu Glu Ala 755 760 765 Page 469 of 3790 Tyr Phe Lys Gly Leu Asp Ser Ser Thr Gly Ala Phe Thr Leu Glu Page 470 of 3790 1010 1015 1020 Ile Phe Leu Ala Val His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Page 472 of 3790 Glu Val Phe Gly Lys Phe Val Ser Asp Asn Leu Asp Asp Ser Glu Leu 405 410 415 Ala Asn Lys Ile Lys Ala Arg Leu Asp Leu Gly Glu Phe Leu Pro Lys 420 425 430 Gin Arg Thr Asn Gin Asn Gly Val Ile Pro Tyr Gin Leu His Gin Val 435 440 445 Glu Leu Thr Gin Ile Leu Glu Lys Gin Gly Lys Tyr Tyr Pro Phe Leu 450 455 460 Ile Thr Pro Asn Pro Val Glu Ser His Arg Asn Asn Ala Pro Tyr Glu 465 470 475 480 Ile Ser Glu Leu Val Ser Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu 485 490 495 Ile Asp Asn Gin Ser Ile Lys Asp Lys Gin Asn Lys Asn Lys Phe Ala 500 505 510 Trp Met Val Arg Gin Lys Gin Gly Gin Ile Thr Pro Trp Asn Phe Glu 515 520 525 Glu Met Val Asp Thr Thr Glu Ser Ala Asn Gin Phe Ile Lys Arg Met 530 535 540 Thr Arg Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro Lys Ser 545 550 555 560 Ser Leu Ile Tyr Gin Lys Phe Met Ile Leu Asp Glu Leu Asn Arg Ile 565 570 575 Lys Ile Asp Gly Lys Lys Leu Thr Ser Lys Leu Lys His Asp Ile Phe 580 585 590 Glu Lys Leu Phe Lys Lys Gin Lys Ser Ile Asn Leu Asp Asn Leu Lys 595 600 605 Asn Tyr Leu Leu Ala Glu Gly Asn Ile Pro Gly Leu Ile Glu Gly Leu 610 615 620 Ser Asp Gly Ile Asn Phe Asn Asn Ser Phe Ser Thr Tyr Ile Asp Tyr 625 630 635 640 Arg Asn Ile Phe Gly Asp Glu Ile Asp Asn Pro Asn Lys Gin Ala Asp 645 650 655 Page 473 of 3790 Phe Glu Lys Met Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile 660 665 670 Phe Lys Arg Lys Leu Lys Glu Ile Thr Trp Leu Thr Pro Glu Gin Ile 675 680 685 Lys Gin Val Ser Ser Lys Arg Tyr Ser Gly Trp Gly Arg Leu Ser Lys 690 695 700 Lys Leu Leu Thr Gin Ile Thr Asp Glu Asn Gly Val Asn Ile Leu Gin 705 710 715 720 Arg Leu Trp Asn Glu Pro Glu Thr Leu Thr Glu Val Leu Ala Asn Pro 725 730 735 Val Ile Lys Arg Lys Ile Ser Glu Ala Asn Ser Leu Phe Val Gin Ile 740 745 750 Asn Lys Val Glu Asn Ile Leu Asp Asp Ala Tyr Thr Ser Pro Gin Asn 755 760 765 Lys Lys Ala Ile Arg Gin Val Ile Arg Val Val Asp Asp Ile Ile Ala 770 775 780 Ala Ala His Gly Lys Lys Pro Ser Gin Ile Ala Ile Glu Phe Ala Arg 785 790 795 800 Ser Ser Gin Asn Lys Ala Lys Val Pro Asp Thr Arg Lys Lys Gin Leu 805 810 815 Asp Lys Ile Tyr Asn Lys Ile Ser Ser Glu Ile Leu Asp Ser Ser Ile 820 825 830 Lys Asn Glu Leu Lys Asn Leu Lys Ser Asn Lys Tyr Leu Ser Lys Asp 835 840 845 Lys Leu Phe Leu Tyr Phe Lys Gin Met Gly Arg Asp Ala Tyr Thr Gly 850 855 860 Asp Lys Leu Ser Leu Asp Gin Leu Gin Asn Tyr Asp Ile Asp His Ile 865 870 875 880 Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu 885 890 895 Thr Gin Lys Pro Ile Asn Ala Lys Lys Ser Asp Tyr Gly Ile Pro Ala 900 905 910 Page 474 of 3790 Gly Leu Pro Thr Glu Ile Tyr Gly Gly Tyr Ser Gly Asn Lys Asp Page 476 of 3790 Arg Arg Ile Lys Ile Lys Asp Leu 1385 1390 99 1114 PRT Eubacterium rectale 99 Met Asn Tyr Thr Glu Lys Glu Lys 1 5 Leu Phe Met Lys Tyr Ile Leu Ala 10 15 Leu Asp Ile Gly Ile Ala Ser Val 20 Gly Trp Ala Ile Leu Asp Lys Glu 25 30 Ser Glu Thr Val Ile Glu Ala Gly 35 40 Ser Asn Ile Phe Pro Glu Ala Ser 45 Ala Ala Asp Asn Gin Leu Arg Arg 50 55 Asp Met Arg Gly Ala Lys Arg Asn 60 Asn Arg Arg Leu Lys Thr Arg Ile 65 70 Asn Asp Phe Ile Lys Leu Trp Glu 75 80 Asn Asn Asn Leu Ser Ile Pro Gin 85 Phe Lys Ser Thr Glu Ile Val Gly 90 95 Leu Lys Val Arg Ala Ile Thr Glu 100 Glu Ile Thr Leu Asp Glu Leu Tyr 105 110 Leu Ile Leu Tyr Ser Tyr Leu Lys 115 120 His Arg Gly Ile Ser Tyr Leu Glu 125 Asp Ala Leu Asp Asp Thr Val Ser 130 135 Gly Ser Ser Ala Tyr Ala Asn Gly 140 Leu Lys Leu Asn Ala Lys Glu Leu 145 150 Glu Thr His Tyr Pro Cys Glu Ile 155 160 Gin Gin Glu Arg Leu Asn Thr Ile 165 Gly Lys Tyr Arg Gly Gin Ser Gin 170 175 Ile Ile Asn Glu Asn Gly Glu Val 180 Leu Asp Leu Ser Asn Val Phe Thr 185 190 Ile Gly Ala Tyr Arg Lys Glu Ile 195 200 Gin Arg Val Phe Glu Ile Gin Lys 205 Page 477 of 3790 Lys Tyr His Pro Glu Leu Thr Asp Glu Phe Cys Asp Gly Tyr Met Leu 210 215 220 Ile Phe Asn Arg Lys Arg Lys Tyr Tyr Glu Gly Pro Gly Asn Glu Lys 225 230 235 240 Ser Arg Thr Asp Tyr Gly Arg Phe Thr Thr Lys Leu Asp Ala Asn Gly 245 250 255 Asn Tyr Ile Thr Glu Asp Asn Ile Phe Glu Lys Leu Ile Gly Lys Cys 260 265 270 Ser Val Tyr Pro Asp Glu Leu Arg Ala Ala Ala Ala Ser Tyr Thr Ala 275 280 285 Gin Glu Tyr Asn Val Leu Asn Asp Leu Asn Asn Leu Thr Ile Asn Gly 290 295 300 Arg Lys Leu Glu Glu Asn Glu Lys His Glu Ile Val Glu Arg Ile Lys 305 310 315 320 Ser Ser Asn Thr Ile Asn Met Arg Lys Ile Ile Ser Asp Cys Met Gly 325 330 335 Glu Asn Ile Asp Asp Phe Ala Gly Ala Arg Ile Asp Lys Ser Gly Lys 340 345 350 Glu Ile Phe His Lys Phe Glu Val Tyr Asn Lys Met Arg Lys Ala Leu 355 360 365 Leu Glu Ile Gly Ile Asp Ile Ser Asn Tyr Ser Arg Glu Glu Leu Asp 370 375 380 Glu Ile Gly Tyr Ile Met Thr Ile Asn Thr Asp Lys Glu Ala Met Met 385 390 395 400 Glu Ala Phe Gin Lys Ser Trp Ile Asp Leu Ser Asp Asp Val Lys Gin 405 410 415 Cys Leu Ile Asn Met Arg Lys Thr Asn Gly Ala Leu Phe Asn Lys Trp 420 425 430 Gin Ser Phe Ser Leu Lys Ile Met Asn Glu Leu Ile Pro Glu Met Tyr 435 440 445 Ala Gin Pro Lys Glu Gin Met Thr Leu Leu Thr Glu Met Gly Val Thr 450 455 460 Page 478 of 3790 Lys Gly Thr Gin Glu Glu Phe Ala Gly Leu Lys Tyr Ile Pro Val Asp 465 470 475 480 Val Val Ser Glu Asp Ile Phe Asn Pro Val Val Arg Arg Ser Val Arg 485 490 495 Ile Ser Phe Lys Ile Leu Asn Ala Val Leu Lys Lys Tyr Lys Ala Leu 500 505 510 Asp Thr Ile Val Ile Glu Met Pro Arg Asp Arg Asn Ser Glu Glu Gin 515 520 525 Lys Lys Arg Ile Asn Asp Ser Gin Lys Leu Asn Glu Lys Glu Met Glu 530 535 540 Tyr Ile Glu Lys Lys Leu Ala Val Thr Tyr Gly Ile Lys Leu Ser Pro 545 550 555 560 Ser Asp Phe Ser Ser Gin Lys Gin Leu Ser Leu Lys Leu Lys Leu Trp 565 570 575 Asn Glu Gin Asp Gly Ile Cys Leu Tyr Ser Gly Lys Thr Ile Asp Pro 580 585 590 Asn Asp Ile Ile Asn Asn Pro Gin Leu Phe Glu Ile Asp His Ile Ile 595 600 605 Pro Arg Ser Ile Ser Phe Asp Asp Ala Arg Ser Asn Lys Val Leu Val 610 615 620 Tyr Arg Ser Glu Asn Gin Lys Lys Gly Asn Gin Thr Pro Tyr Tyr Tyr 625 630 635 640 Leu Thr His Ser His Ser Glu Trp Ser Phe Glu Gin Tyr Lys Ala Thr 645 650 655 Val Met Asn Leu Ser Lys Lys Lys Glu Tyr Ala Ile Ser Arg Lys Lys 660 665 670 Ile Gin Asn Leu Leu Tyr Ser Glu Asp Ile Thr Lys Met Asp Val Leu 675 680 685 Lys Gly Phe Ile Asn Arg Asn Ile Asn Asp Thr Ser Tyr Ala Ser Arg 690 695 700 Leu Val Leu Asn Thr Ile Gin Asn Phe Phe Met Ala Asn Glu Ala Asp 705 710 715 720 Page 479 of 3790 Thr Lys Val Lys Val Ile Lys Gly Ser Tyr Thr His Gin Met Arg Cys 725 730 735 Asn Leu Lys Leu Asp Lys Asn Arg Asp Glu Ser Tyr Ser His His Ala 740 745 750 Val Asp Ala Met Leu Ile Gly Tyr Ser Glu Leu Gly Tyr Glu Ala Tyr 755 760 765 His Lys Leu Gin Gly Glu Phe Ile Asp Phe Glu Thr Gly Glu Ile Leu 770 775 780 Arg Lys Asp Met Trp Asp Glu Asn Met Ser Asp Glu Val Tyr Ala Asp 785 790 795 800 Tyr Leu Tyr Gly Lys Lys Trp Ala Asn Ile Arg Asn Glu Val Val Lys 805 810 815 Ala Glu Lys Asn Val Lys Tyr Trp His Tyr Val Met Arg Lys Ser Asn 820 825 830 Arg Gly Leu Cys Asn Gin Thr Ile Arg Gly Thr Arg Glu Tyr Asp Gly 835 840 845 Lys Gin Tyr Lys Ile Asn Lys Leu Asp Ile Arg Thr Lys Glu Gly Ile 850 855 860 Lys Val Phe Ala Lys Leu Ala Phe Ser Lys Lys Asp Ser Asp Arg Glu 865 870 875 880 Arg Leu Leu Val Tyr Leu Asn Asp Arg Arg Thr Phe Asp Asp Leu Cys 885 890 895 Lys Ile Tyr Glu Asp Tyr Ser Asp Ala Ala Asn Pro Phe Val Gin Tyr 900 905 910 Glu Lys Glu Thr Gly Asp Ile Ile Arg Lys Tyr Ser Lys Lys His Asn 915 920 925 Gly Pro Arg Ile Asp Lys Leu Lys Tyr Lys Asp Gly Glu Val Gly Ala 930 935 940 Cys Ile Asp Ile Ser His Lys Tyr Gly Phe Glu Lys Gly Ser Lys Lys 945 950 955 960 Val Ile Leu Glu Ser Leu Val Pro Tyr Arg Met Asp Val Tyr Tyr Lys 965 975 Page 480 of 3790 970 Glu Glu Asn His Ser Tyr Tyr Leu Val Gly Val Lys Gin Ser Asp Ile 980 985 990 Lys Phe Glu Lys Gly Arg Asn Val Ile Asp Glu Glu Ala Tyr Ala Arg 995 1000 1005 Cys 100 1362 PRT Lactobacillus paracasei 100 Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 15 10 15 Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 20 25 30 Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 35 40 45 Ala Ala Ala Lys Arg Arg Ala Gly Arg Thr Thr Arg Arg Arg Leu Ser Page 482 of 3790 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Thr Gly 305 310 315 320 Lys Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Thr Gin His His Glu 325 330 335 Asp Leu Gin Leu Phe Lys Ala Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Thr Ala Lys Ala Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Asp Ala Ala Pro Phe Leu Arg Glu Asn Phe Val Lys Ala Leu Thr Lys 370 375 380 Asp Val Thr Ala His Pro Asn Thr Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Leu Ala Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ala Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Lys Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Glu 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Arg Tyr 530 535 540 Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 545 550 555 560 Page 483 of 3790 Ser Ile Glu Gin Lys Gin Gin Val Ile Arg Glu Leu Phe Glu Arg His 565 570 575 Asn Ser Val Thr Ile Lys Gin Phe Ala Glu Asn Leu Arg Ala His Gly 580 585 590 Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gin Leu Lys Ser Leu Leu Pro 610 615 620 Glu Ala Ile Asp Asp Pro Ala Lys Gin Ala Asp Ile Glu Asn Ile Ile 625 630 635 640 Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 645 650 655 Lys Glu Ile Ser Trp Leu Gly Ser Glu Ala Ile Thr Lys Leu Ser Asn 660 665 670 Ile Arg Tyr Arg Gly Trp Gly Gin Phe Ser Arg Lys Phe Leu Asn Gly 675 680 685 Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gin Glu Leu Leu Leu Ser 690 695 700 Thr Asn Asn Leu Met Gin Ile Leu Thr Asp Glu Thr Leu Gin Lys Lys 705 710 715 720 Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Thr Ala Asn Ile Asn Asp 725 730 735 Ala Ile Asp Asn Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 740 745 750 Gin Val Leu Arg Val Val Asp Asp Ile Lys Arg Ala Ala Asp Gly Gin 755 760 765 Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 770 775 780 Gly Lys Arg Thr Arg Ala Arg Gin His Gin Leu Gin Glu Ile Tyr Ala 785 790 795 800 Asn Ala Ala His Glu Leu Ile Asp Thr Ala Val Arg Gly Glu Leu Glu 805 810 815 Page 484 of 3790 Lys Gin Arg Asp Val Asp Glu Leu Asp Arg Ile Tyr Asn Phe Lys Page 486 of 3790 101 1056 PRT Actinobacillus minor 101 Page 487 of 3790 Asp Asn Lys Glu Leu Gly Ala Leu Leu Lys Gly Val Ser Glu Asn Arg 145 150 155 160 Gin Leu Leu Gin Ala Gin Ala Phe Ser Thr Pro Ala Glu Ile Ala Ile 165 170 175 Lys Lys Phe Gin Gin Glu Glu Gly His Ile Arg Asn Gin Arg Gly Ala 180 185 190 Tyr Ser His Thr Phe Asp Arg Asn Asp Leu Leu Ala Glu Leu Arg Leu 195 200 205 Leu Phe Gin Lys Gin Arg Glu Phe Asn Asn Pro Tyr Thr Ser Gin Ser 210 215 220 Leu Glu Gin Ala Ile Ala Glu Leu Leu Met Trp Gin Lys Pro Ala Leu 225 230 235 240 Ser Gly Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro 245 250 255 Ser Glu Tyr Lys Ala Pro Lys Asn Ser Tyr Ser Ala Glu Tyr Phe Val 260 265 270 Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asn Gly Ala Asp 275 280 285 Arg Gly Leu Thr Ala Glu Glu Arg Gin Leu Leu Ile Asn Gin Pro Phe 290 295 300 Glu Lys Ala Lys Phe Thr Tyr Ala Gin Ala Arg Lys Leu Leu Glu Leu 305 310 315 320 Ser Asp Leu Ala Ile Phe Lys Gly Val Arg Tyr Gly Lys Asp Asn Ala 325 330 335 Glu Ser Ala Thr Leu Met Glu Met Lys Ala Trp His Ala Ile Arg Lys 340 345 350 Ala Leu Glu Ser Asn Gly Leu Lys Thr Glu Trp Asn Gly Leu Lys Thr 355 360 365 Lys Pro Glu Leu Leu Asp Lys Ile Gly Thr Ala Phe Ser Ile Tyr Lys 370 375 380 Thr Asp Glu Asp Ile Ser Gin Tyr Leu Asn Gly Glu Leu Ser Pro Ala 385 390 395 400 Page 488 of 3790 Val Leu Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Arg 405 410 415 Leu Ser Leu Gin Ser Leu Ala Lys Ile Leu Pro Leu Met Glu Gin Gly 420 425 430 Leu Arg Tyr Asp Glu Ala Cys Lys Gin Val Tyr Gly Asp His Tyr Gly 435 440 445 Lys Lys Glu Gin Leu Glu Leu Arg Phe Leu Pro Lys Ile Pro Val Glu 450 455 460 Asp Ile Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gin Ala Arg Lys 465 470 475 480 Val Ile Asn Gly Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 485 490 495 Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Phe Ser Glu Arg Arg Asp 500 505 510 Ile Ser Lys Arg Gin Glu Glu Asn Arg Asn Glu Arg Gin Arg Ala Val 515 520 525 Glu Lys Phe Lys Glu Phe Phe Pro His Phe Val Gly Glu Pro Lys Ala 530 535 540 Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Gin Gin His Gly Lys Cys 545 550 555 560 Leu Tyr Ser Gly Lys Glu Leu Asp Leu Asn Arg Leu Leu Glu Lys Gly 565 570 575 Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 580 585 590 Ser Phe Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gin Asn Lys 595 600 605 Gly Asn Gin Thr Pro Tyr Glu Trp Leu Asn Gly Lys Glu Asn Ala Glu 610 615 620 Arg Trp Lys Leu Phe Gin Ala Leu Val Asn Gly Ser Arg Phe Pro Tyr 625 630 635 640 Ser Lys Lys Gin Arg Ile Leu Thr Lys Tyr Leu Asp Glu Asp Gly Phe 645 650 655 Page 489 of 3790 Arg Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys 660 665 670 Asn Phe Ile Glu Asp Asn Met Gin Leu Val Gly Gin Gly Lys Lys Arg 675 680 685 Val Phe Ala Ser Asn Gly Gin Ile Thr Ala Leu Leu Arg Arg Ser Trp 690 695 700 Gly Ile Gin Lys Val Arg Glu Asp Asn Asp Arg His His Ala Val Asp 705 710 715 720 Ala Val Val Val Ala Cys Ser Thr Arg Ala Leu Gin Lys Lys Ile Thr 725 730 735 Asp Tyr Val Arg Tyr Lys Glu Met Asn Val Phe Thr Gly Glu Lys Ile 740 745 750 Asp Gin Glu Thr Gly Glu Ile Ile Lys Phe His Phe Pro Glu Pro Trp 755 760 765 Lys Phe Phe Arg Gin Glu Val Glu Ile Arg Val Phe Ser Glu Thr Pro 770 775 780 Ala Glu Asp Val Val Ile Ala Leu Pro Asp Arg Pro Gin Ala Asn His 785 790 795 800 Glu Phe Ile Gin Pro Leu Phe Val Ser Arg Ala Pro Thr Arg Lys Met 805 810 815 Thr Gly Gin Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg Leu Ala 820 825 830 Glu Gly Leu Ser Val Ser Arg Val Pro Leu Thr Gin Leu Lys Leu Lys 835 840 845 Asp Leu Glu Asn Met Val Asn Arg Glu Arg Glu Lys Ala Leu Tyr Glu 850 855 860 Ala Leu Lys Val Arg Leu Glu Lys Phe Asn Asn Asp Pro Ala Lys Ala 865 870 875 880 Phe Ala Asp Pro Phe Tyr Lys Lys Gly Gly Gin Gin Val Lys Ala Val 885 890 895 Arg Val Glu Gin Val Gin Lys Ser Gly Val Leu Val Arg Gin Glu Asn 900 910 Page 490 of 3790 905 Pro Val Arg 1055 102 1081 PRT Neisseria flavescens 102 Met Thr Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 15 10 15 Ile Gly Ile Ala 20 Ser Val Gly Trp Ala Met Val 25 Glu Ile Asp Glu 30 Glu Glu Asn Pro 35 Ile Arg Leu Ile Asp Leu 40 Gly Val Arg Val 45 Phe Glu Arg Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu Page 492 of 3790 Leu Ile Asp Met Pro Tyr Lys Asn Lys Leu Thr Tyr Ala Lys Ala Arg 305 310 315 320 Glu Leu Leu Gly Leu Asp Asp Thr Ala Phe Phe Lys Gly Leu Arg Tyr 325 330 335 Gly Lys Asp Asn Ala Glu Ser Ala Thr Leu Met Glu Met Lys Ala Tyr 340 345 350 His Ala Ile Arg Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys Lys 355 360 365 Ser Pro Leu Ser Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr Ala 370 375 380 Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys Gly 385 390 395 400 Cys Leu Gin Pro Glu Ile Leu Asp Ala Leu Leu Lys His Ile Asn Phe 405 410 415 Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val Pro 420 425 430 Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Thr Tyr 435 440 445 Gly Asp His Tyr Gly Glu Lys Asn Ser Glu Glu Met Leu Tyr Leu Pro 450 455 460 Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala Leu 465 470 475 480 Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly Ser 485 490 495 Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser Phe 500 505 510 Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys Asp 515 520 525 Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe Val 530 535 540 Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu Gin 545 550 555 560 Page 493 of 3790 Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Ala Ile Asp Ile Arg Arg 565 570 575 Leu Asn Gly Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser 580 585 590 Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly Ser 595 600 605 Glu Asn Gin Asn Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Leu Asn Gly 610 615 620 Lys Asp Asn Ser Arg Glu Trp Leu Glu Phe Lys Ala Arg Val Glu Thr 625 630 635 640 Ser Arg Phe Pro His Ser Lys Lys Gin Arg Val Leu Leu Gin Lys Phe 645 650 655 Asp Glu Lys Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val 660 665 670 Asn Arg Phe Leu Cys Gin Phe Val Ala Asp His Met Gin Leu Thr Gly 675 680 685 Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn Leu 690 695 700 Leu Arg Gly Phe Trp Gly Leu His Lys Val Arg Ala Glu Asn Asp Arg 705 710 715 720 His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met 725 730 735 Gin Gin Lys Ile Thr Cys Phe Val Arg Tyr Lys Glu Met Asn Ala Phe 740 745 750 Asp Gly Lys Thr Val Asp Lys Glu Thr Gly Glu Val Leu His Gin Lys 755 760 765 Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met Ile 770 775 780 Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala Asp 785 790 795 800 Thr Pro Glu Lys Leu Arg Ala Leu Leu Ala Glu Lys Leu Ser Ser Arg 805 810 815 Page 494 of 3790 Leu Val Leu Met Gin Lys Tyr Gin Ile Asp Glu Leu Gly Lys Glu Page 495 of 3790 1055 1060 1065 Ile Arg Pro Cys Arg Leu Lys Lys Arg Pro Pro Val Arg 1070 1075 1080 103 1392 PRT Gemella haemolysans 103 Met Ala Asn Lys Thr Trp Tyr Leu 1 5 Gly Leu Asp Ile Gly Ser Ala Ser 10 15 Val Gly Trp Ala Ala Thr Asp Thr 20 Gly Tyr Lys Ile Ile Arg Lys Asn 25 30 Lys Lys Arg Leu Trp Gly Val Arg 35 40 Leu Phe Glu Glu Ala Lys Thr Ala 45 Glu Asp Arg Arg Gly Tyr Arg Ser 50 55 Ser Arg Arg Arg Leu Ala Arg Arg 60 Lys Trp Arg Leu Asn Leu Leu Glu 65 70 Glu Leu Phe Thr Ser Glu Val Lys 75 80 Lys Val Asp Glu Asn Phe Phe Leu 85 Arg Leu Lys Glu Ser Gin Tyr His 90 95 Tyr Glu Asp Lys Thr His Lys Val 100 Pro Tyr Ala Ile Phe Asn Asp Lys 105 110 Asp Tyr Thr Asp Lys Asp Tyr Tyr 115 120 Lys Asp Tyr Pro Thr Ile Tyr His 125 Leu Arg Ser Lys Leu Met Thr Glu 130 135 Glu Asn Pro Asp Ile Arg Lys Val 140 Phe Leu Ala Ile His His Ile Ile 145 150 Lys Asn Arg Gly His Phe Leu Leu 155 160 Gin Gly Gin Ser Phe 165 Lys Asp Gly Asn Leu Asn Asn 170 Leu Ile Lys Glu 175 Leu Leu Glu Leu Asp 180 Ile Leu His Val 185 Gly Phe Glu Val Thr Glu Glu 190 Val Val Asp Lys Ile Ala Asp Ile Ser Leu Glu Lys Lys Thr Ser Lys Page 496 of 3790 195 200 205 Asp Lys Leu Asn Asp Ile Lys Glu Leu Tyr Pro Lys Glu Lys Gin Leu 210 215 220 Leu Glu Val Phe Arg Leu Ile Phe Gly Gly Lys Thr Ser Leu Asp Lys 225 230 235 240 Leu Phe Ala Ile Asp Glu Tyr Lys Glu Leu Asp Ala Ala Ile Lys Ser 245 250 255 Val Ser Phe Lys Glu Lys Ile Tyr Glu Glu Val Arg His Asp Tyr Glu 260 265 270 Gin Val Leu Ser Asn Tyr Ile Glu Leu Leu Asp Leu Ala Lys Leu Val 275 280 285 Tyr Asp Ser Ile Ile Leu Ser Asp Ile Lys Lys Glu Gly Lys Thr Leu 290 295 300 Ser Glu Ser Lys Val Glu Leu Phe Glu Lys His Arg Asp Asp Leu Leu 305 310 315 320 Lys Leu Lys Asn Leu Val Lys Asn Asp Ser Lys Leu Ser Glu Asp Lys 325 330 335 Lys Val Glu Leu Tyr Ala Leu Ile Phe Lys Glu Asp Lys Asp Lys Gly 340 345 350 Thr Asn Tyr Val Asn Tyr Ile Arg Lys Ser Glu Glu Gly Lys Gly Cys 355 360 365 Asn Tyr Glu Asp Phe Lys Lys Phe Leu Val Lys Glu Leu Ala Lys Leu 370 375 380 Glu Glu Ser Ser Val Lys Thr Glu Ile Ile Lys Asp Leu Glu Leu Glu 385 390 395 400 Gin Phe Leu Pro Leu Gin Arg Thr Lys Asp Asn Ser Val Val Pro Tyr 405 410 415 Gin Ile His Lys Glu Glu Leu Val Lys Ile Leu Asp Asn Ala Ala Arg 420 425 430 Tyr His Ser Phe Leu Asn Glu Lys Asp Glu Ser Gly Tyr Asn Val Arg 435 440 445 Page 497 of 3790 Glu Lys Val Ile Gin Leu Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly 450 455 460 Pro Leu Asn Ser Ser Lys Lys Ala Lys Glu Gly Gly Phe Ala Trp Ser 465 470 475 480 Val Arg Asn Thr Gly Tyr Glu Asn Thr Pro Val Thr Pro Trp Asn Tyr 485 490 495 Ser Lys Val Ile Asp Glu Ser Ala Ser Ala Glu Lys Phe Ile Thr Asn 500 505 510 Leu Thr Asn Lys Cys Thr Tyr Leu Lys Gly Glu Asp Val Leu Pro Lys 515 520 525 Ser Ser Leu Leu Tyr Ser Glu Phe Ala Leu Leu Asn Glu Leu Asn Ala 530 535 540 Leu Lys Tyr Asp Gly Asn Arg Ile Ser Leu Glu Ala Arg Asn Thr Ile 545 550 555 560 Ile Glu Lys Leu Phe Lys Gin Gin Gly Lys Lys Val Thr Lys Thr Ser 565 570 575 Ile Lys Asn Leu Leu Lys Ala Glu Gly Tyr Ile Asp Gly Lys Gly Glu 580 585 590 Ile Thr Gly Ile Asp Ile Thr Val Lys Asn Asp Leu Lys Ser Tyr Arg 595 600 605 Asp Phe Lys Lys Ile Leu Gly Asn Lys Phe Asn Ser Glu His Val Glu 610 615 620 Asn Ile Ile Leu Trp Ile Thr Leu Tyr Gly Glu Ser Arg Lys Leu Ile 625 630 635 640 Lys Ala Lys Ile Glu Ser Val Tyr Gly Glu Val Tyr Ser Lys Asp Glu 645 650 655 Ile Thr Lys Met Ser Arg Leu Val Tyr Lys Asp Trp Gly Arg Phe Ser 660 665 670 Arg Lys Leu Leu Thr Glu Leu Val Ser Lys Lys Leu Tyr Asn Glu Glu 675 680 685 Thr Gly Glu Cys Leu Asn Ile Ile Gly Ala Met Arg Gin Asn Asn Ile 690 695 700 Page 498 of 3790 Leu Phe Met Glu Leu Leu Ala Asp Arg Phe Asp Tyr Ser Lys Gin Ile 705 710 715 720 Val Glu Phe Asn Lys Glu Leu Gin Glu Asp Val Thr Glu Ile Ala Pro 725 730 735 Glu Ile Leu Asp Asp Leu Tyr Val Ser Pro Ala Val Lys Arg Ser Ile 740 745 750 Trp Gin Thr Val Arg Ile Val Glu Glu Leu Lys Lys Ile Ile Gly Cys 755 760 765 Ala Pro Ala Lys Ile Phe Val Glu Thr Thr Arg Ser Asn Gin Glu Lys 770 775 780 Lys Lys Pro Thr Asp Ser Arg Lys Lys Gin Leu Glu Leu Ala Tyr Lys 785 790 795 800 Ala Val Lys Lys Asp Val Lys Glu Leu Glu Lys Glu Ile Gly Thr Ile 805 810 815 Asn Phe Asp Val Leu Asn Asp Arg Leu Ser Ser Val Glu Pro Ser Lys 820 825 830 Leu Lys Ala Lys Lys Leu Tyr Leu Tyr Tyr Thr Gin Leu Gly Arg Cys 835 840 845 Met Tyr Ser Glu Glu Pro Ile Asn Ile Ser Glu Leu Phe Asp Asn Asn 850 855 860 Lys Tyr Asp Ile Asp His Ile Tyr Pro Gin Ser Lys Ile Lys Asp Asp 865 870 875 880 Ser Phe Thr Asn Thr Val Leu Val Lys Arg Glu Ser Asn Ala Ala Lys 885 890 895 Thr Asp Arg Tyr Pro Leu Gly Ser Asp Ile Gin Thr Pro Ser Asn Arg 900 905 910 Arg Phe Trp Lys Phe Leu Lys Glu Lys Gly Leu Ile Ser Asp Glu Lys 915 920 925 Tyr Asn Arg Leu Val Arg Thr Glu Glu Phe Ser Asp Glu Glu Leu Ser 930 935 940 Gly Phe Ile Ala Arg Gin Leu Val Glu Thr Ser Gin Ser Val Lys Ala 945 950 955 960 Page 499 of 3790 Val Ala Ser Ile Leu Gly Glu Leu Asn Pro Glu Thr Ser Ile Cys Tyr 965 970 975 Ser Lys Ala Glu Asn Val Ser Ser Phe Arg Gin Asn Phe Gly Lys Ile 980 985 990 Lys Lys Gly Asp Arg Asp Ser Lys Asn Asn Asp Gin Leu Ile Lys Val 995 1000 1005 Gin Ile Phe Cys Arg Ala Tyr Glu Lys Ile Lys Asp Phe Lys Leu Page 500 of 3790 1190 1195 1200 1385 1390 104 702 PRT Helicobacter pullorum 104 Met Arg Lys Ile Leu Lys Ile Asp Glu Arg Ile Gin Phe Lys Glu Val Page 503 of 3790 Arg Ala Leu Ser Leu Gly Lys Ile Arg Gin Ile Gly Thr Lys Ile Val 515 520 525 Ala Asn Gly Pro Met Val Arg Val Asp Ile Phe Lys His Thr Gin Ser 530 535 540 Gly Arg Phe Tyr Ala Val Pro Ile Tyr Thr Met Asp Phe Ala Leu Gly 545 550 555 560 Ile Leu Pro Asn Lys Ala Val Val Ser Gly Lys Asp Lys Asp Arg Ile 565 570 575 Ile Lys Asp Trp Leu Glu Met Asp Ser Cys Tyr Glu Phe Cys Phe Ser 580 585 590 Leu Phe Lys Asp Asp Val Ile Glu Val Gin Lys Arg Asp Met Glu Lys 595 600 605 Pro Glu Leu Ala Tyr Phe Val Ser Leu Asp Ala Ser Asp Gly Arg Ile 610 615 620 Lys Val Arg His His Cys Asn Asp Ile Thr Lys Ile Asn Glu Asn Gin 625 630 635 640 Lys Lys Leu Phe Ser Glu Ala Ile Glu Lys Glu Val Val Gly Arg Gly 645 650 655 Ser Ile Gin Asn Leu Lys Val Phe Lys Lys Tyr Lys Val Ser Pro Leu 660 665 670 Gly Glu Ile Lys Glu Ala Lys Tyr Glu Pro Arg Gin Pro Ile Ala Leu 675 680 685 Lys Thr Ser Pro Lys Lys His Arg Lys Gin Asn Asn Ala Gin 690 695 700 105 1371 PRT Streptococcus dysgalactiae 105 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Page 504 of 3790 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Page 505 of 3790 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gin Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys 1010 1015 1020 Ser Glu Gin Glu Ile Gly Lys Ala Thr Ala Lys Arg Phe Phe Tyr 1025 1030 1035 Page 508 of 3790 Page 509 of 3790 Gly Gly Asp 1370 106 1007 PRT Helicobacter canadensis 106 Page 510 of 3790 Ser Lys Glu Asp Leu Ala Arg Val Ile Leu His Ile Ala Lys His Arg 115 120 125 Gly Tyr Met Asn Lys Asn Gin Lys Thr Ser Gin Asp Ser Glu Lys Gly 130 135 140 Ala Ile Leu Ser Ala Ile Lys Glu Asn Ser Asn Lys Ile Lys His Tyr 145 150 155 160 Gin Thr Ala Gly Glu Tyr Phe Tyr Lys Glu Leu Phe Glu Asn Leu Arg 165 170 175 Asp Gly Thr Lys Glu Phe Lys Asn Ile Arg Asn Lys Ala Met Lys Asn 180 185 190 Glu Lys Thr Gly Asn Met Glu Ser Thr Tyr Tyr Asn Thr Ile Leu Ala 195 200 205 Ser Asp Leu Glu Lys Glu Leu Lys Leu Ile Leu Glu Lys Gin Gin Ala 210 215 220 Tyr His Asn Tyr Ser Asp Thr Phe Ile Lys Glu Val Leu Glu Ile Ala 225 230 235 240 Phe Tyr Gin Arg Pro Leu Lys Asp Phe Ser His Leu Val Gly Ser Cys 245 250 255 Thr Phe Tyr Glu Asn Glu Lys Arg Ala Cys Lys Asn Ser Tyr Ser Ala 260 265 270 Trp Glu Phe Ile Ala Leu Gly Lys Ile Ile Asn Thr Leu Glu Ser Ile 275 280 285 Lys Lys Asp Thr Gly Glu Ile Phe Ser Asn Glu Ile Ile Thr Gin Ile 290 295 300 Leu Lys Glu Val Leu Asp Lys Gly Ser Leu Ser Tyr Thr Lys Leu Arg 305 310 315 320 Lys Met Ile Asn Leu Asp Glu Lys Val Lys Phe Lys Gly Leu Lys Tyr 325 330 335 Asp Lys Glu Gly Val Glu Lys Thr Asn Leu Ile Glu Phe Lys Lys Leu 340 345 350 Lys Glu Phe Lys Lys Ala Leu Gly Glu His Asn Leu Glu Arg Lys Thr Page 511 of 3790 355 360 365 Leu Asp Glu Ile Ala Thr His Ile Thr Leu Thr Lys Asp Glu Asn Gin 370 375 380 Leu Lys Lys Gin Leu Glu Gin Tyr Ala Leu Ser Gin Asn Gin Ile Asp 385 390 395 400 Ala Leu Ala Glu Leu Asp Phe Asn Asp His Ile Asn Leu Ser Phe Lys 405 410 415 Ala Leu Tyr Glu Ile Leu Pro Leu Met Glu Lys Gly Lys Arg Tyr Asp 420 425 430 Glu Ala Cys Asn Glu Leu Gly Leu Lys Ala Lys Thr Ser Asn Gin Lys 435 440 445 Ser Glu Phe Leu Pro Ala Phe Cys Asp Ser Ile Phe Ala Gin Glu Leu 450 455 460 Thr Asn Pro Ile Val Asn Arg Ala Ile Ser Glu Tyr Arg Lys Val Leu 465 470 475 480 Asn Arg Leu Leu Lys Lys Tyr Gly Lys Met His Lys Ile His Ile Glu 485 490 495 Leu Ala Arg Asp Ala Gly Leu Ser Lys Glu Ala Arg Asn Lys Ile Glu 500 505 510 Lys Glu Gin Lys Glu Asn Lys Asp Ile Asn Asp Lys Ala Glu Lys Thr 515 520 525 Cys Lys Glu Phe Gly Leu Lys Pro Asn Ala Lys Asn Ile Leu Lys Ile 530 535 540 Lys Leu Trp Arg Glu Gin Gly Glu Ile Cys Ala Tyr Ser Gly Lys Lys 545 550 555 560 Ile Thr Ile Asp Asp Leu Lys Glu Asp Lys Ala Leu Glu Val Asp His 565 570 575 Ile Tyr Pro Tyr Ser Arg Ser Tyr Asp Asp Ser Tyr Asn Asn Lys Val 580 585 590 Leu Val Phe Ile Lys Glu Asn Gin Leu Lys Leu Asn Gin Thr Pro Tyr 595 600 605 Page 512 of 3790 Glu Ala Phe Gly Ser Asn Gin Glu Lys Trp Ser Lys Ile Gin Val Leu 610 615 620 Ala Gin Lys Leu Pro Tyr Lys Lys Lys Asn Arg Ile Leu Asp Glu Asn 625 630 635 640 Phe Lys Asn Lys Asp Gin Ile Glu Phe Ile Ser Arg Asn Leu Asn Asp 645 650 655 Thr Arg Tyr Ala Thr Ser Leu Ile Ala Lys Tyr Thr Lys Glu Tyr Leu 660 665 670 Glu Phe Leu Pro Leu Ser Asp Asp Glu Asp Ile Ser Leu Lys Ser Gly 675 680 685 Glu Lys Gly Ser Lys Thr His Val Gin Thr Met Asn Gly Met Leu Thr 690 695 700 Ser Val Leu Arg His Ala Trp Gly Phe Ser Gin Lys Asp Arg Asn Asn 705 710 715 720 His Leu His His Ala Leu Asp Ala Ile Ile Ile Ala Tyr Ser Thr Asn 725 730 735 Ser Ile Ile Lys Ala Phe Ser Asp Phe Lys Lys Asn Gin Glu Ile Leu 740 745 750 Lys Ala Lys Leu Tyr Ala Lys Lys Leu Thr Ser Glu Glu Tyr Lys Asn 755 760 765 Gin Ser Lys Phe Thr Gly Phe Glu Lys Tyr Arg Ser Lys Ile Leu Glu 770 775 780 Lys Leu Asp Ser Ile Phe Val Ser Lys Pro Pro Asn Lys Asn Thr Lys 785 790 795 800 Gly Ala Leu His Glu Gin Thr Phe Tyr Ser Tyr Gin Asp Ile Leu Glu 805 810 815 Glu Tyr Lys Thr Gin Glu Gly Leu Lys Arg Ala Leu Glu Cys Gly Lys 820 825 830 Val Arg Lys Ile Gly Thr Lys Tyr Val Val Asn Asp Arg Met Val Arg 835 840 845 Leu Asp Ile Phe Lys Lys Asp Asn Lys Phe Tyr Gly Ile Pro Ile Tyr 850 855 860 Page 513 of 3790 Page 514 of 3790 Glu Tyr Gly Ile Lys Arg Glu Glu Val Thr Glu Pro Leu Leu Lys Phe 85 90 95 Ile Asn Gly Leu Leu Asn Arg Arg Gly Tyr Thr Tyr Ile Ser Glu Glu 100 105 110 Val Asp Glu Glu Ser Met Asn Val Ser Pro Leu Pro Phe Ser Glu Met 115 120 125 Met Pro Asp Tyr Phe Asn Ser Ser Ala Pro Leu Leu Glu Gin Leu Ala 130 135 140 Lys Leu Leu Ser Asp Lys Asn Lys Leu Val Arg Phe Arg Ala Glu Gly 145 150 155 160 Lys Ile Pro Ser Asn Lys Asn Glu Phe Lys Lys Leu Leu Asp Thr Ala 165 170 175 Leu Asp Gly Lys Tyr Lys Asp Glu Lys Lys Glu Leu Ser Glu Ala Trp 180 185 190 Gly Asn Ile Leu Ile Ala Ser Glu Asn Val Leu Lys Ser Thr Val Asp 195 200 205 Gly His Lys Ser Arg Ser Glu Tyr Leu Ala Asn Ile Lys Glu Asp Ile 210 215 220 Lys Ser Asn Glu Glu Leu Glu Lys Gin Ile Ser Ser Lys Glu Ile Asp 225 230 235 240 Gly Phe Tyr Asn Leu Val Gly His Leu Ser Asn Phe Gin Leu Arg Leu 245 250 255 Leu Arg Lys Tyr Phe Asn Asp Pro Asn Met Ser Gly Val Ser Tyr Trp 260 265 270 Asp Glu Lys Arg Leu Glu Lys Tyr Phe Tyr Gin Trp Val Gin Gly Trp 275 280 285 His Thr Lys Gly Gly Thr Asp Glu Ala Glu Lys Lys Asn Ile Ile Leu 290 295 300 Lys Thr Lys Gly Ala Pro Leu Leu Lys Thr Leu Lys Ser Leu Ser Ala 305 310 315 320 Asp Leu Thr Ile Pro Pro Tyr Glu Asp Gin Asn Asn Arg Arg Pro Pro 325 330 335 Page 515 of 3790 Lys Cys Gin Ser Val Leu Leu Ser Asp Glu Lys Leu Thr Met His Tyr 340 345 350 Pro Lys Trp Lys Glu Trp Val Gly Gin Leu Val Lys Gin Asn Asp Asn 355 360 365 Ala Tyr Leu Asn Glu Asn Val Thr Leu Ala Asn Ala Leu His Arg Ile 370 375 380 Val Glu Arg Ser Arg Ser Ile Asp Pro Tyr Gin Leu Arg Leu Leu Ile 385 390 395 400 Ser Ile Thr Asp Ala Glu Lys Arg Asn Asp Leu Ala Gly Tyr Lys Arg 405 410 415 Leu Lys Leu Ser Leu Gly Ser Glu Val Asp Glu Phe Leu Leu Leu Val 420 425 430 Lys Asn Ile Val Asp Glu Thr Lys Glu Ala Arg Glu Gly Leu Trp Phe 435 440 445 Glu Thr Glu Asn Lys Leu Phe Phe Lys Cys Gly Lys Thr Pro Pro Arg 450 455 460 Lys Glu Lys Leu Lys Ser Thr Leu Leu Ser Ala Val Leu Gly Lys Asn 465 470 475 480 Leu Ser Asp Asp Glu Gin Ser Ser Phe Ile Glu Glu Phe Trp Lys Ser 485 490 495 Gly Thr Pro Lys Ile Glu Arg Arg Asn Val Arg Gly Trp Cys Arg Leu 500 505 510 Ala Ser Gin Val Gin Lys Thr Tyr Gly Val Tyr Leu Lys Glu Tyr Gly 515 520 525 Leu Gin Gin Leu His Lys Leu Glu Ala Gly Lys Lys Leu Asp Asp Lys 530 535 540 Pro Leu Ala Leu Leu Tyr Lys Asn Ser Gly Leu Ile Ala Ser Lys Ile 545 550 555 560 Gly Glu Ala Leu Asn Ile Glu Pro Asp Glu Val Ser Arg Phe Ala Ser 565 570 575 Pro His Ser Leu Ala Gin Ile Phe Asn Ile Ile Glu Gly Asp Val Ala Page 517 of 3790 Page 518 of 3790 Page 519 of 3790 108 1082 PRT Neisseria meningitidis 108 Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 15 10 15 Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 20 25 30 Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 35 40 45 Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Val Arg Arg Leu 50 55 60 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 65 70 75 80 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gin Ala Ala Asp 85 90 95 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Page 520 of 3790 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asp Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Ile Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys Page 522 of 3790 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gin Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 885 890 895 Page 523 of 3790 109 1334 PRT Listeria monocytogenes 109 Met Lys Lys Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Leu Thr Asp Gin Tyr Asp Leu Val Lys Arg Lys Met 20 25 30 Page 524 of 3790 Lys Ile Ser Gly Asp Ser Glu Lys Lys Gin Ile Lys Lys Asn Phe Trp 35 40 45 Gly Val Arg Leu Phe Glu Lys Gly Glu Thr Ala Ala Lys Arg Arg Met 50 55 60 Ser Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Ile Gin Met Asn Glu Val Asp Asp Asn 85 90 95 Phe Phe Asn Arg Leu Lys Glu Ser Phe Tyr Ala Glu Ser Asp Lys Lys 100 105 110 Tyr Asn Arg His Pro Phe Phe Gly Thr Val Glu Glu Glu Val Ala Tyr 115 120 125 Tyr Lys Asp Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ile Asp 130 135 140 Ser Gin Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Ala Leu Asp Thr 165 170 175 Lys Asn Thr Ser Ile Asp Glu Met Phe Lys Gin Phe Leu Gin Ile Tyr 180 185 190 Asn Gin Val Phe Ala Asn Asp Ile Glu Glu Ala Ser Leu Lys Lys Thr 195 200 205 Glu Lys Asn Gin Glu Val Ala Gin Ile Leu Ala Glu Lys Phe Thr Arg 210 215 220 Lys Asp Lys Leu Asp Lys Ile Leu Ser Leu Tyr Pro Gly Glu Lys Thr 225 230 235 240 Thr Gly Val Phe Ala Gin Phe Val Asn Ile Ile Val Gly Ser Thr Gly 245 250 255 Lys Phe Lys Lys His Phe Asn Leu His Glu Lys Lys Asp Ile Asn Cys 260 265 270 Ala Glu Asp Thr Tyr Asp Thr Asp Leu Glu Ser Leu Leu Ala Ile Ile 275 280 285 Page 525 of 3790 Gly Asp Glu Phe Ala Glu Val Phe Val Ala Ala Lys Asn Ala Tyr Asn 290 295 300 Ala Val Val Leu Ser Asn Ile Ile Thr Val Thr Asp Ser Thr Thr Arg 305 310 315 320 Ala Lys Leu Ser Ala Ser Leu Ile Glu Arg Phe Glu Asn His Lys Glu 325 330 335 Asp Leu Lys Lys Met Lys Arg Phe Val Arg Thr Tyr Leu Pro Glu Lys 340 345 350 Tyr Asp Glu Ile Phe Asp Asp Thr Glu Lys His Gly Tyr Ala Gly Tyr 355 360 365 Ile Ser Gly Lys Thr Lys Gin Ala Asp Phe Tyr Lys Tyr Met Lys Ala 370 375 380 Thr Leu Glu Lys Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 385 390 395 400 Glu Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile 405 410 415 Pro His Gin Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gin Gin 420 425 430 Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 435 440 445 Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 450 455 460 Gin Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 465 470 475 480 Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 485 490 495 Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 500 505 510 Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Met Val Tyr Asn 515 520 525 Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gin Gly Lys Thr Asn Tyr 980 985 990 Asn Gly Val Val Ala Asn Thr Leu Leu Lys Val Tyr Pro Gin Leu Glu 995 1000 1005 Pro Glu Phe Val Tyr Gly Glu Tyr His Gin Phe Gly Trp Phe Lys 1010 1015 1020 Ala Asn Lys Ala Thr Ala Lys Lys Gin Phe Tyr Thr Asn Ile Met 1025 1030 1035 Page 528 of 3790 Page 529 of 3790 110 1337 PRT Enterococcus faecalis 110 Page 530 of 3790 Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 165 170 175 Glu Asn Ile Ser Val Lys Glu Gin Phe Gin Gin Phe Met Ile Ile Tyr 180 185 190 Asn Gin Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 195 200 205 Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 210 215 220 Thr Lys Lys Ser Glu Lys Val Leu Gin Gin Phe Pro Gin Glu Lys Ala 225 230 235 240 Asn Gly Leu Phe Gly Gin Phe Leu Lys Leu Met Val Gly Asn Lys Ala 245 250 255 Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 260 265 270 Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 275 280 285 Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 290 295 300 Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 305 310 315 320 Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gin Glu 325 330 335 Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 340 345 350 Tyr Asp Asn Leu Phe Lys Asn Glu Gin Lys Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Ala His Ala Gly Lys Val Ser Gin Leu Lys Phe Tyr Gin Tyr Val 370 375 380 Lys Lys Ile Ile Gin Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 385 390 395 400 Ile Ala Gin Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Page 533 of 3790 Page 534 of 3790 111 1426 PRT Capnocytophaga ochracea 111 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 15 10 15 Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 20 25 30 Page 535 of 3790 Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gin Ser Asp Phe 35 40 45 Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 50 55 60 Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gin Gin Arg Arg Lys Tyr Leu 65 70 75 80 Ile Asp Leu Leu Gin Lys Ala Asn Leu Ile Thr Pro Ser Ser Ile Leu 85 90 95 Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gin Leu Arg Ala 100 105 110 Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Ile Leu 115 120 125 Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 130 135 140 Thr Glu Asp Glu Gly Gin Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 145 150 155 160 Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gin Leu Ser Leu Gin Leu Leu 165 170 175 Gin Gin Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gin 180 185 190 Lys Glu Phe Asp Leu Val Trp Asn Phe Gin Lys Gin Phe Tyr Pro Asp 195 200 205 Ile Leu Thr Asp Ile Phe Tyr Lys Glu Leu Gin Gly Lys Gly Lys Asp 210 215 220 Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Thr Glu 225 230 235 240 Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gin Ala Tyr Gin Trp Arg 245 250 255 Ala Glu Ala Ile Ser Lys Gin Leu Ser Lys Glu Glu Val Ala Tyr Val 260 265 270 Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly Page 536 of 3790 275 280 285 Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gin Thr Val 290 295 300 Gly Gin Tyr Leu Tyr Ala Lys Leu Gin Glu Asn Arg His Asn Ser Leu 305 310 315 320 Lys Asn Lys Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu Arg 325 330 335 Ile Trp Glu Thr Gin Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 340 345 350 Lys Lys Gin Ile Arg Asp Val Val Ile Phe Tyr Gin Arg Lys Pro Lys 355 360 365 Ser Gin Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 370 375 380 Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Asn Ile Gly Ala Arg 385 390 395 400 Val Val Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys Ile Trp Gin 405 410 415 Ile Leu Asn Asn Val Ile Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 420 425 430 Ile Ser Ala Lys Thr Thr Gin Leu Asp Leu Leu Asn Glu Ser Ser Gin 435 440 445 Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gin Leu Leu Phe Asp Glu 450 455 460 Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 465 470 475 480 Gly Tyr Ser Pro Gin Glu Trp Glu Ile Asn Tyr Asn Gin Leu Glu Gly 485 490 495 Asn Arg Thr Gin Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 500 505 510 Met Glu Ala His Asp Val Lys Asp Ile Leu Gin Ile Lys Ser Ala Lys 515 520 525 Page 537 of 3790 Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 530 535 540 Glu Lys Val Lys Ala Ile Phe Gin Thr Leu Gly Ile Cys Thr Lys Ile 545 550 555 560 Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Glu Gin Asp 565 570 575 Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 580 585 590 Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 595 600 605 Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gin Asp 610 615 620 Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 625 630 635 640 Ile Lys Glu Asn Gin Tyr Ser Thr Ala Cys Glu Lys Ala Gly Tyr Lys 645 650 655 His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 660 665 670 Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 675 680 685 Val Glu Lys Ile Leu Asn Gin Met Ile Asn Val Val Asn Ala Leu Ile 690 695 700 Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 705 710 715 720 His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 725 730 735 Ala Gin Lys Arg Tyr Glu Met Thr Gin Asn Ile Asn Lys Ala Lys Leu 740 745 750 Glu His Gin Lys Ile Ser Glu Ile Leu Gin Lys Glu Phe Gly Ile Lys 755 760 765 Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Gin Glu Leu 770 775 780 Page 538 of 3790 Asn Tyr Ser Val Ile Leu Ala Ile Glu Glu Lys Glu Thr Ile Lys 1010 1015 1020 Val Pro Thr Asn Asn Gly Lys Asn Lys Arg Val Phe Ile Glu Pro 1025 1030 1035 Page 539 of 3790 Leu Asn Lys Glu Gly Lys Glu Ile Pro Val Asp Tyr Val Ser Thr Ile Asn His Leu Gly Asp Ile Val Ser Ile Gly Glu Tyr 1415 1420 1425 112 1424 PRT Parabacteroides sp. 112 Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Asn Glu Ala Glu Thr Asp Glu Glu Val Ser Ser Ile Ile 20 25 30 Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Thr 35 40 45 Gin Asn Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Glu Arg Thr Leu Lys Page 543 of 3790 Asp Leu Thr Lys Glu Gly Lys Glu Leu Glu Met Gin Pro Tyr Phe Arg 565 570 575 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Ser Thr Gly 580 585 590 Asn Gly Lys Leu Ile Glu Lys Ile Met Gin Leu Cys Gly Val Glu Lys 595 600 605 Glu Tyr Ala Val Glu Leu Ala Ser Leu Ser Phe Gin Asp Asp Tyr Gly 610 615 620 Ser Leu Ser Ala Lys Ala Ile Lys Arg Ile Leu Pro Tyr Leu Lys Glu 625 630 635 640 Gly Asn Leu Tyr Asp Val Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser 645 650 655 Lys Ser Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Gly 660 665 670 Lys Leu Glu Val Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 675 680 685 Lys Ile Leu Ser Gin Met Val Asn Val Ile Asn Thr Ile Ile Asp Thr 690 695 700 Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 705 710 715 720 Lys Ser Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Ile Ala Lys Ser 725 730 735 Thr Arg Glu His Glu Glu Ile Arg Lys Leu Leu Gin Asp Glu Phe Gly 740 745 750 Met Met Asn Val Ser Arg Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu 755 760 765 Glu Leu Lys Asp Asn Gly Tyr Lys Thr Leu Tyr Ser Asn Gin Tyr Ile 770 775 780 Pro Lys Glu Lys Ile Phe Ser Lys Glu Ile Asp Ile Glu His Ile Ile 785 790 795 800 Pro Gin Ser Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu 805 810 815 Page 544 of 3790 Asn Thr Lys Ile Gin Gin Thr Pro Arg Gly Gin Leu His Leu Glu Page 546 of 3790 Ser Cys Gly Tyr Val Val 20 Thr Asp Lys 25 Gin Asn Asn Ile Leu Lys Leu 30 Lys Gly Lys 35 Thr Ala Ile Gly Ala Arg 40 Leu Phe Lys Glu Gly Gin Ala 45 Ala Ala Asp 50 Arg Arg Ser Phe Arg Thr 55 Thr Arg Arg Arg 60 Leu Ala Arg Arg His Trp Arg Leu Gly Leu Leu Glu Glu Ile Phe Asp Pro Glu Met 65 70 75 80 Page 547 of 3790 Glu Lys Ile Asp Pro Asn Phe Phe Arg Arg Leu Lys Glu Ser Asp Tyr 85 90 95 Ser Pro Lys Asp Ser Arg Lys Gin Phe Asn Ala Ile Val Phe Lys Ser 100 105 110 Ile Lys Ala Asp Lys Arg Phe Tyr Lys Lys Tyr Pro Thr Ile Tyr His 115 120 125 Leu Arg Asn Ala Leu Met His Asp Asn Gin Lys His Asp Leu Arg Glu 130 135 140 Ile Phe Met Ala Val His His Ile Val Lys Tyr Arg Gly Asn Phe Leu 145 150 155 160 Arg Glu Asp Ser Val Asn Ala Phe Lys Ala Ala Lys Phe Ser Leu Arg 165 170 175 Gly Glu Asp Gly Ile Gly Pro Val Asp Lys Leu Asn Asp Leu Leu Lys 180 185 190 Glu Ile Tyr Ser Glu Tyr Ser Pro Glu Leu Ala Thr Asn Asn Leu Ser 195 200 205 Lys Ile Glu Asp Ile Ile Lys Asp Lys Asn Leu Tyr Lys Gin Asp Lys 210 215 220 Leu Lys Gin Val Ala Thr Leu Leu Ile Lys Glu Ala Asp Ser Lys Asp 225 230 235 240 Lys Ala Lys Leu Asn Lys Asp Ile Ala Lys Gin Val Ala Asn Ser Phe 245 250 255 Met Gly Tyr Met Phe Arg Leu Asp Thr Leu Phe Ser Leu Thr Asp Val 260 265 270 Asp Val Lys Asp Tyr Lys 275 Leu Lys 280 Phe Ser Asp Ala Asn 285 Ile Asp Glu Ser Leu Asp Asp Leu 290 Thr Ser Leu Leu 295 Thr Asp Ala 300 Gin Ile Glu Phe Val 305 Leu Glu Leu Gin Ser 310 Ile Tyr Asn Thr Ile Val 315 Leu Asn Glu Ile 320 Val Pro Asp Gly Met Ser Leu Ser Glu Ser Met Ile Lys Lys Tyr Asp 325 330 335 Page 548 of 3790 Asp His Lys Glu Asp Leu Lys Ile Phe Lys Glu Tyr Ile Asp Ser Leu 340 345 350 Ser Asp Gin Lys Lys Ala Lys Lys Leu Leu Ser Ala Tyr Asn Leu Tyr 355 360 365 Val Asn Tyr Arg Lys Ser Asp Leu Val Glu Ala Lys Asn Leu Phe Lys 370 375 380 Asn Lys Lys Val Gly Asp Lys Asn Phe Ala Asp Val Ile Ser Asn Phe 385 390 395 400 Glu Val Phe Gly Lys Phe Val Ser Asp Asn Leu Asp Asp Ser Glu Leu 405 410 415 Ala Asn Lys Ile Lys Ala Arg Leu Asp Leu Gly Glu Phe Leu Pro Lys 420 425 430 Gin Arg Thr Asn Gin Asn Gly Val Ile Pro Tyr Gin Leu His Gin Val 435 440 445 Glu Leu Thr Gin Ile Leu Glu Lys Gin Gly Lys Tyr Tyr Pro Phe Leu 450 455 460 Ile Thr Pro Asn Pro Val Glu Ser His Arg Asn Asn Ala Pro Tyr Glu 465 470 475 480 Ile Ser Glu Leu Val Ser Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu 485 490 495 Ile Asp Asn Gin Ser Ile Lys Asp Lys Gin Asn Lys Asn Lys Phe Ala 500 505 510 Trp Met Val Arg Gin Lys Gin Gly Gin Ile Thr Pro Trp Asn Leu Glu 515 520 525 Glu Met Val Asp Thr Thr Glu Ser Ala Asn Gin Phe Ile Lys Arg Met 530 535 540 Thr Arg Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro Lys Ser 545 550 555 560 Ser Leu Val Tyr Gin Lys Phe Met Ile Leu Asp Glu Leu Asn Arg Ile 565 570 575 Lys Ile Asp Gly Lys Lys Leu Thr Ser Glu Leu Lys His Asp Ile Phe 580 585 590 Page 549 of 3790 Glu Lys Leu Phe Lys Lys Gin Lys Ser Ile Asn Leu Asp Asn Leu Lys 595 600 605 Asn Tyr Leu Leu Val Glu Gly Asn Ile Pro Gly Leu Ile Glu Gly Leu 610 615 620 Ser Asp Gly Ile Asn Phe Asn Asn Ser Phe Ser Thr Tyr Ile Asp Tyr 625 630 635 640 Arg Asn Ile Phe Gly Asp Glu Ile Asp Asn Pro Asn Lys Gin Ala Asp 645 650 655 Phe Glu Lys Met Ile Glu Trp Ser Thr Val Phe Glu Asp Arg Lys Ile 660 665 670 Phe Lys Arg Lys Leu Lys Glu Ile Thr Trp Leu Thr Ser Glu Gin Ile 675 680 685 Lys Gin Val Ser Ser Lys Arg Tyr Ser Gly Trp Gly Arg Leu Ser Lys 690 695 700 Lys Leu Leu Thr Gin Ile Thr Asp Glu Asn Gly Val Asn Ile Leu Gin 705 710 715 720 Arg Leu Trp Asn Glu Pro Glu Thr Leu Thr Glu Val Leu Ala Asn Pro 725 730 735 Val Ile Lys Arg Lys Ile Val Glu Ala Asn Ser Ser Phe Thr Lys Ala 740 745 750 Lys Asp Met Lys Asp Ile Leu Val Glu Ala Tyr Thr Ser Pro Gin Asn 755 760 765 Lys Lys Ala Ile Arg Gin Val Met Arg Val Val Asp Asp Ile Ile Ala 770 775 780 Ala Ala His Gly Lys Lys Pro Ser Gin Ile Ala Ile Glu Phe Ala Arg 785 790 795 800 Glu Asp Gin Asp Asn Pro Gin Met Thr Lys Ser Arg Lys Ala Gin Leu 805 810 815 Asp Gin Ile Tyr Ala Lys Ile Ser Asp Glu Phe Leu Asp Asp Ala Val 820 825 830 Lys Asn Glu Leu Lys Asn Met Lys Asp Asn Lys Pro Leu Ala Lys Asp Page 550 of 3790 Page 551 of 3790 Page 552 of 3790 114 1140 PRT Roseburia intestinalis 114 Page 553 of 3790 Arg Gly Phe Arg Ser Thr Arg Lys Ala Glu Thr Ala Ala Lys Glu Asn 145 150 155 160 Gly Ala Val Leu Lys Ala Thr Asp Glu Asn Gin Lys Arg Met Gin Glu 165 170 175 Lys Gly Tyr Arg Thr Val Gly Glu Met Ile Tyr Leu Asp Glu Ala Phe 180 185 190 Arg Thr Gly Cys Ser Trp Ser Glu Lys Gly Tyr Ile Leu Thr Pro Arg 195 200 205 Asn Lys Ala Glu Asn Tyr Gin His Thr Met Leu Arg Ala Met Leu Val 210 215 220 Glu Glu Val Lys Glu Ile Phe Ser Ser Gin Arg Arg Leu Gly Asn Glu 225 230 235 240 Lys Ala Thr Glu Glu Leu Glu Glu Lys Tyr Leu Glu Ile Met Thr Ser 245 250 255 Gin Arg Ser Phe Asp Leu Gly Pro Gly Met Gin Pro Asp Gly Lys Pro 260 265 270 Ser Pro Tyr Ala Met Glu Gly Phe Ser Asp Arg Val Gly Lys Cys Thr 275 280 285 Phe Leu Gly Asp Gin Gly Glu Leu Arg Gly Ala Lys Gly Thr Tyr Thr 290 295 300 Ala Glu Tyr Phe Val Ala Leu Gin Lys Ile Asn His Thr Lys Leu Val 305 310 315 320 Asn Gin Asp Gly Glu Thr Arg Asn Phe Thr Glu Glu Glu Arg Arg Ala 325 330 335 Leu Thr Leu Leu Leu Phe Thr Gin Lys Glu Val Lys Tyr Ala Ala Val 340 345 350 Arg Lys Lys Leu Gly Leu Pro Glu Asp Ile Leu Phe Tyr Asn Leu Asn 355 360 365 Tyr Lys Lys Ala Ala Thr Lys Glu Glu Gin Gin Lys Glu Asn Gin Asn 370 375 380 Thr Glu Lys Ala Lys Phe Ile Gly Met Pro Tyr Tyr His Asp Tyr Lys 385 390 395 400 Page 554 of 3790 Lys Cys Leu Glu Glu Arg Val Lys Tyr Leu Thr Glu Asn Glu Val Arg 405 410 415 Asp Leu Phe Asp Glu Ile Gly Met Ile Leu Thr Cys Tyr Lys Asn Asp 420 425 430 Asp Ser Arg Thr Glu Arg Leu Ala Lys Leu Gly Leu Val Pro Ile Glu 435 440 445 Met Glu Gly Leu Leu Ala Tyr Thr Pro Thr Lys Phe Gin His Leu Ser 450 455 460 Met Lys Ala Met Arg Asn Ile Ile Pro Phe Leu Glu Lys Gly Met Thr 465 470 475 480 Tyr Asp Lys Ala Cys Glu Glu Ala Gly Tyr Asp Phe Lys Ala Asp Ser 485 490 495 Lys Gly Thr Lys Gin Lys Leu Leu Thr Gly Glu Asn Val Asn Gin Thr 500 505 510 Ile Asn Glu Ile Thr Asn Pro Val Val Lys Arg Ser Val Ser Gin Thr 515 520 525 Val Lys Val Ile Asn Ala Ile Ile Arg Thr Tyr Gly Ser Pro Gin Ala 530 535 540 Ile Asn Ile Glu Leu Ala Arg Glu Met Ser Lys Thr Phe Glu Glu Arg 545 550 555 560 Arg Lys Ile Lys Gly Asp Met Glu Lys Arg Gin Lys Asn Asn Glu Asp 565 570 575 Val Lys Lys Gin Ile Gin Glu Leu Gly Lys Leu Ser Pro Thr Gly Gin 580 585 590 Asp Ile Leu Lys Tyr Arg Leu Trp Gin Glu Gin Gin Gly Ile Cys Met 595 600 605 Tyr Ser Gly Lys Thr Ile Pro Leu Glu Glu Leu Phe Lys Pro Gly Tyr 610 615 620 Asp Ile Asp His Ile Leu Pro Tyr Ser Ile Thr Phe Asp Asp Ser Phe 625 630 635 640 Arg Asn Lys Val Leu Val Thr Ser Gin Glu Asn Arg Gin Lys Gly Asn Ser Val Val Arg Ser Glu Lys Arg Met Gly Phe Ser 1130 1135 1140 Page 557 of 3790 Glu Asn Cys Gly Phe Glu Phe Leu 10 15 Thr Glu Glu Glu Lys Glu Leu Ile 20 Lys Pro Leu Phe Phe Arg Ile Ser 25 30 Lys Pro Ser Phe Gin Phe Ala Asp 35 40 Ile Glu Lys Lys Leu Lys Gly Lys 45 Asn Gly Phe Trp Lys Phe Asn Tyr 50 55 Arg Lys Asp Thr Asn Val Ser Gly 60 Cys Pro Val Ser Ala Gly Leu Lys 65 70 Asn Ile Phe Gly Asp Glu Ala Ser 75 80 Ala Glu Ser Trp Lys Asp Lys Lys 85 Val Gly Gin Tyr Asp Met Cys Asp 90 95 Ile Trp His Val Leu Phe Asp Phe 100 Asp Asp Glu Glu Lys Leu Leu Glu 105 110 Phe Ala Lys Arg Lys Leu Phe Leu 115 120 Ser Asp Glu Ala Ala Lys Lys Phe 125 Cys Ala Ile Arg Ile Gin Gin Gly 130 135 Tyr Ala Asn Leu Ser Leu Lys Ala 140 Ile Arg Lys Ile Thr Pro Phe Leu 145 150 Arg Lys Gly Tyr Ile Tyr Ser Thr 155 160 Ala Val Phe Leu Ala Asn Ile Pro 165 Phe Met Ile Gly Arg Asp Ile Phe 170 175 Leu Gin Asn Glu Lys Glu Ile Glu 180 Asp Ser Val Lys Asn Ile Ile Gly 185 190 Thr Leu Arg Asp Lys Asn Asn Ile 195 200 Ile Val Leu Ala Asn Arg Cys Ile 205 Glu Ser Ala Phe Lys Asp Lys Asp Asn Asp Phe Arg Phe Glu Glu Trp 210 215 220 Page 558 of 3790 Asp Lys Ala Leu Val Glu Asn Ser Ala Trp Asp Leu Phe Gly Lys Lys 225 230 235 240 Lys Trp Asn Glu Tyr Asp Glu Glu Lys Arg Lys Thr Ile Ile Ser Gin 245 250 255 Val Ser Glu Lys Val Glu Asp Asn Leu Lys Ile Ala Val Gly Lys Asn 260 265 270 Pro Asn Asp Tyr Lys Tyr Pro Leu Leu Arg Thr Asp Asp Leu Ile Met 275 280 285 Asp Tyr Leu Asn Gin Lys Gly Phe Val Val Lys Gly Glu Leu Tyr His 290 295 300 Pro Ser Asp Thr Asp Tyr Asn Phe Glu Thr Pro Val Pro Ala Glu Asp 305 310 315 320 Gly Lys Ile Tyr Leu Ala Ser Pro Arg Ser Pro Ser Val Lys Asn Pro 325 330 335 Val Val Met Arg Ala Leu His Gin Leu Arg Lys Leu Val Asn Tyr Leu 340 345 350 Ile Lys Thr Gly Lys Ile Asp Ser Thr Thr Lys Ile Asn Val Glu Leu 355 360 365 Ala Asn Asp Val Asn Asp Lys Asn Gin Arg Lys Ala Ile Glu Glu Leu 370 375 380 Ala Lys Thr Asn Glu Lys Asn Asn Ala Asp Ala Arg Lys Lys Ile Glu 385 390 395 400 Glu Leu Cys Asn Glu Ala Gly Phe Lys Val Val Pro Thr Glu Ser Asp 405 410 415 Ile Lys Lys Phe Arg Leu Trp Lys Glu Gin Asn Glu Thr Cys Pro Tyr 420 425 430 Thr Gly Lys His Ile Ser Phe Thr Asp Leu Phe Gly Pro Ile Pro Lys 435 440 445 Phe Asp Phe Glu His Thr Ile Pro Arg Ser Leu Ser Tyr Asp Asp Ser 450 455 460 Leu Glu Asn Leu Thr Leu Cys Asp Ser Glu Phe Asn Arg Asn Ile Lys 465 470 475 480 Page 559 of 3790 Lys Gin Arg Leu Pro Ser Glu Leu Pro Asp Phe Glu Glu Ile Asn Lys 485 490 495 Arg Phe Leu Lys Phe Tyr Glu Asp Lys Ile Asp Asn Cys Leu Arg Ile 500 505 510 Ile Glu Leu Asn Ser Lys Ser Gly Gly Ser Tyr Glu Glu Pro Ala Val 515 520 525 Lys Asp Leu Arg Ile Val Lys Lys His Lys Ala Gin Tyr Glu Leu Asn 530 535 540 Tyr Tyr Lys Glu Lys Leu Arg Arg Phe Ser Ser Thr Glu Ile Thr Ser 545 550 555 560 Gly Phe Lys His Ser Gin Leu Asn Asp Thr Arg Ile Ile Thr Lys Phe 565 570 575 Ser Leu Ser Tyr Leu Lys Gly Val Phe Asp His Val Gin Pro Val Lys 580 585 590 Gly Ser Met Thr Asp Thr Phe Lys Arg Gin Trp Gly Leu Met Glu Arg 595 600 605 Asn Glu Ile Lys Asp Arg Ser Asn His Thr His His Thr Val Asp Ala 610 615 620 Leu Thr Val Ala Cys Ile Asn Arg Gly Lys Phe Asn Leu Leu Ser Glu 625 630 635 640 Ala Ile Lys Asn Ser Ser Asp Gly Lys His Leu Lys Phe Pro Lys Pro 645 650 655 Trp Glu Thr Phe Asp Thr Asp Val Leu Asn Ala Val Arg Tyr Ile Ile 660 665 670 Pro Lys Tyr Phe Ser Asp Glu Ser Ser Leu Arg Gin Ser Lys Lys Ile 675 680 685 Leu Arg Gly Arg Asp Gly Lys Pro Val Leu Lys Asn Gly Lys Ala Val 690 695 700 Phe Ile Gin Gly Ala Thr Ala Arg Gly Ser Leu His Lys Asp Thr Phe 705 710 715 720 Tyr Gly Cys Ile Lys Thr Val Pro Glu Lys Gly Gly Lys Ser Glu Met Page 563 of 3790 Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 465 470 475 480 Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 485 490 495 Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 500 505 510 Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gin Lys Phe Ser Ile Tyr 515 520 525 Asn Glu Leu Thr Lys Val Arg Tyr Gin Asp Glu Arg Gly Gin Met Asn 530 535 540 Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 545 550 555 560 Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gin Glu Phe Leu Tyr Leu 565 570 575 Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 580 585 590 Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 595 600 605 Lys Arg Glu Met Lys Gin Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 610 615 620 Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 625 630 635 640 Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 645 650 655 Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 660 665 670 Lys Glu Leu Ile Gin Gly Ile Arg Asp Lys Gin Ser Asn Lys Thr Ile 675 680 685 Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 690 695 700 Asn Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 705 710 715 720 Page 564 of 3790 Ile Lys Lys Ala Gin Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 725 730 735 Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin 740 745 750 Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 755 760 765 Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Arg 770 775 780 Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 785 790 795 800 Lys Asp Phe Gly Ser Gin Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 805 810 815 Ser Leu Gin Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Arg 820 825 830 Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 835 840 845 Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 850 855 860 Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 865 870 875 880 Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 885 890 895 Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 900 905 910 Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 915 920 925 Gin Leu Val Glu Thr Arg Gin Ile Thr Lys His Val Ala Gly Ile Leu 930 935 940 His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Asp Pro Ile Arg Lys 945 950 955 960 Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gin Phe Arg Asn 965 975 Page 565 of 3790 970 Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 980 985 990 His Asp Ala Tyr Leu Asn Gly Val Val Ala Leu Ala Leu Leu Lys Lys 995 1000 1005 Tyr Pro Gin Leu Ala Pro Glu Phe Val Tyr Gly Glu Tyr Leu Lys 1010 1015 1020 Phe Asn Ala His Lys Ala Asn Lys Ala Thr Val Lys Lys Glu Phe 1025 1030 1035 Tyr Ser Asn Ile Met Lys Phe Phe Glu Ser Asp Thr Pro Val Cys 1040 1045 1050 Asp Glu Asn Gly Glu Ile Phe Trp Asp Lys Ser Lys Ser Ile Ala 1055 1060 1065 Gin Val Lys Lys Val Ile Asn His His His Met Asn Ile Val Lys 1070 1075 1080 Lys Thr Glu Ile Gin Lys Gly Gly Phe Ser Lys Glu Thr Val Glu 1085 1090 1095 Pro Lys Lys Asp Ser Ser Lys Leu Leu Pro Arg Lys Asn Asn Trp 1100 1105 1110 Asp Pro Ala Lys Tyr Gly Gly Leu Gly Ser Pro Asn Val Ala Tyr 1115 1120 1125 Thr Val Ala Phe Thr Tyr Glu Lys Gly Lys Ala Arg Lys Arg Thr 1130 1135 1140 Asn Ala Leu Glu Gly Ile Thr Ile Met Glu Arg Glu Ala Phe Glu 1145 1150 1155 Gin Ser Pro Val Leu Phe Leu Lys Asn Lys Gly Tyr Glu Gin Ala 1160 1165 1170 Glu Ile Glu Met Lys Leu Pro Lys Tyr Ala Leu Phe Glu Leu Glu 1175 1180 1185 Asn Gly Arg Lys Arg Met Val Ala Ser Asn Lys Glu Ala Gin Lys 1190 1195 1200 Page 566 of 3790 Gly Lys 1340 117 1363 PRT Lactobacillus rhamnosus 117 Page 567 of 3790 Arg Thr Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Ala Pro His 65 70 75 80 Ile Thr Lys Ile Asp Pro Asp Phe Phe Leu Arg Gin Lys Tyr Ser Glu 85 90 95 Ile Ser Pro Lys Asp Lys Asp Arg Phe Lys Tyr Glu Lys Arg Leu Phe 100 105 110 Asn Asp Arg Thr Asp Ala Glu Phe Tyr Glu Asp Tyr Pro Ser Met Tyr 115 120 125 His Leu Arg Leu His Leu Met Thr His Thr His Lys Ala Asp Pro Arg 130 135 140 Glu Ile Phe Leu Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 145 150 155 160 Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 165 170 175 Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gin Val Tyr Pro 180 185 190 Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 195 200 205 Lys Leu Leu Asp Glu Gin Ala Thr Pro Ser Asp Thr Gin Lys Ala Leu 210 215 220 Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 225 230 235 240 Arg Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 245 250 255 Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 260 265 270 Ser Asn Trp Gin Phe Ser Met Gly Gin Leu Asp Asp Lys Trp Ser Asn 275 280 285 Ile Glu Thr Ser Met Thr Asp Gin Gly Thr Glu Ile Phe Glu Gin Ile 290 295 300 Gin Glu Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Page 568 of 3790 Met Ser Leu Ser Gin Ala Lys Val Ala Asp Tyr Gly Gin His Lys Glu 325 330 335 Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 340 345 350 Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 355 360 365 Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gin Leu Leu Asn Arg 385 390 395 400 Met Gly Gin Ala Asn Phe Met Leu Lys Gin Arg Thr Lys Ala Asn Gly 405 410 415 Ala Ile Pro Ile Gin Leu Gin Gin Arg Glu Leu Asp Gin Ile Ile Ala 420 425 430 Asn Gin Ser Lys Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Ala His Arg Trp Lys Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 His Ile Pro Tyr Tyr Val Gly Pro Leu Ile Thr Pro Lys Gin Gin Ala 465 470 475 480 Glu Ser Gly Glu Asn Val Phe Ala Trp Met Val Arg Lys Asp Pro Ser 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Lys Tyr 530 535 540 Glu Val 545 Leu Asn Glu Leu Asn Asn Val 550 Arg Ile Asn Asn Glu Cys 555 Leu 560 Gly Thr Asp Gin Lys Gin Arg Leu Ile Arg Glu Val Phe Glu Arg His 565 570 575 Page 569 of 3790 Ser Ser Val Thr Ile Lys Gin Val Ala Asp Asn Leu Val Ala His Gly 580 585 590 Asp Phe Ala Arg Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr His Gin Leu Lys Glu Ile Leu His 610 615 620 Glu Ala Ile Asp Asp Pro Thr Lys Leu Leu Asp Ile Glu Asn Ile Ile 625 630 635 640 Thr Trp Ser Thr Val Phe Glu Asp His Thr Ile Phe Glu Thr Lys Leu 645 650 655 Ala Glu Ile Glu Trp Leu Asp Pro Lys Lys Ile Asn Glu Leu Ser Gly 660 665 670 Ile Arg Tyr Arg Gly Trp Gly Gin Phe Ser Arg Lys Leu Leu Asp Gly 675 680 685 Leu Lys Leu Gly Asn Gly His Thr Val Ile Gin Glu Leu Met Leu Ser 690 695 700 Asn His Asn Leu Met Gin Ile Leu Ala Asp Glu Thr Leu Lys Glu Thr 705 710 715 720 Met Thr Glu Leu Asn Gin Asp Lys Leu Lys Thr Asp Asp Ile Glu Asp 725 730 735 Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 740 745 750 Gin Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gin 755 760 765 Asp Pro Ser Trp Leu Phe Ile Glu Thr Ala Asp Gly Thr Gly Thr Ala 770 775 780 Gly Lys Arg Thr Gin Ser Arg Gin Lys Gin Ile Gin Thr Val Tyr Ala 785 790 795 800 Asn Ala Ala Gin Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 805 810 815 Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 820 830 Page 570 of 3790 825 Page 571 of 3790 Page 572 of 3790 118 1234 PRT Prevotella tannerae 118 Page 573 of 3790 Tyr Thr Leu Gly Arg Ala Leu Tyr His Leu Thr Gin Arg Arg Gly Phe 165 170 175 Leu Ser Asn Arg Leu Asp Gin Asn Glu Glu Ala Glu Glu Thr Gly Lys 180 185 190 Val Lys Ser Ala Ile Ser Glu Leu Ser Lys Glu Met Lys Glu Ala Gly 195 200 205 Cys Glu Phe Leu Gly Asp Tyr Phe Tyr Leu Leu Tyr Arg Thr Glu Gly 210 215 220 Asn Arg Val Arg Ile Arg Ser Arg Tyr Thr Asp Arg Glu Lys His Tyr 225 230 235 240 Leu Gin Glu Phe Lys Glu Ile Cys Arg Val Gin Glu Leu Asp Glu Asp 245 250 255 Leu Ala Lys Ala Leu Glu Lys Thr Ile Phe Phe Gin Arg Pro Leu Lys 260 265 270 Ser Gin Arg Gin Gly Val Gly Lys Cys Thr Met Glu Lys Gly His Ser 275 280 285 Arg Cys Ala Val Ser His Pro Leu Tyr Glu Glu Tyr Arg Leu Leu Cys 290 295 300 Tyr Leu Asn Asn Ile Arg Ile Lys Thr Pro Ser Asp Asp Arg Leu Arg 305 310 315 320 Pro Leu Asn Ala Glu Glu Arg Glu Lys Ile Thr Pro Leu Phe Tyr Lys 325 330 335 Glu Lys Asn Phe Asp Phe Glu Lys Ile Ala Lys Lys Leu Ala Gly Lys 340 345 350 Thr Pro Phe Gly Trp Ile Arg Asp Ala Glu Asp Trp Pro Tyr Gin Phe 355 360 365 Asn Tyr Arg Met Thr Gin Glu Ala Pro Ala Cys Pro Thr Thr Ala Gin 370 375 380 Leu Ile Lys Val Phe Gly Glu Asp Trp Lys Ala Ala Leu Ala Glu Thr 385 390 395 400 Tyr Thr Met Ser Ala Lys Gin Asp Gly Thr Leu Lys Thr Glu Asp Glu 405 410 415 Page 574 of 3790 Ile Cys Thr Asp Ile Trp Asn Val Leu Tyr Ser Phe Ser Ser Lys Glu 420 425 430 Lys Leu Lys Glu Phe Gly Leu Lys Lys Leu Gin Leu Asp Glu Val Gin 435 440 445 Ala Lys Ala Phe Ser Glu Ile Arg Leu Thr Arg Asp Phe Ala Ser Leu 450 455 460 Ser Leu Lys Ala Ile Arg Lys Ile Leu Phe Phe Leu Arg Thr Gly Glu 465 470 475 480 Asp Tyr Ser Lys Ala Ile Phe Leu Ala Asn Ile Pro Thr Ile Val Gly 485 490 495 Glu Glu Ile Trp Asn Asp Ile Glu Arg Arg Ser Arg Leu Leu Tyr Lys 500 505 510 Val Asp Leu Ala Leu Arg Pro Gin Glu Glu Arg Asp Ala Glu Glu His 515 520 525 Arg Thr Ile Ala Glu Arg Ile Lys Ala Ala Val Ala Ala Glu Val Pro 530 535 540 Asp Ala Pro Ile Asp Leu Leu Tyr His Pro Ser Met Ile Glu Ala Tyr 545 550 555 560 Pro Asp Ala Lys Arg Asn Glu Arg Phe Asp Cys Tyr Gin Leu Gly Ser 565 570 575 Pro Lys Thr Asn Ala Val Arg Asn Pro Met Ala Met Arg Ser Leu His 580 585 590 Met Val Arg Lys Val Ile Asn His Leu Leu Arg Lys His Ile Ile Asp 595 600 605 Glu Lys Thr Glu Ile His Ile Glu Tyr Ala Arg Glu Leu Asn Asp Ala 610 615 620 Asn Lys Arg Gin Ala Ile Ala Asp Trp Gin Arg Glu Leu Ser Lys Arg 625 630 635 640 His Thr Ala Tyr Ala Gin Asn Ile Arg Gin Leu Tyr Lys Ala Glu Thr 645 650 655 Gly Leu Val Ile Glu Pro Thr Lys Ala Asp Ile Leu Lys Tyr Gin Leu Page 577 of 3790 Leu 119 1496 PRT Prevotella veroralis 119 Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Lys Val Cys Val Asp Asp Asn Gly Asn Tyr Leu Arg Asp Ile Lys 20 25 30 Leu Gly Ser Arg Ile Ile Pro Met Ser Gin Asp Val Leu Gly Asn Phe 35 40 45 Asp Lys Gly Val Thr Glu Ser Gin Thr Ser Val Arg Thr Gly Phe Arg 50 55 60 Gly Val Arg Arg Ile Arg Glu Arg Ser Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 His Arg Val Leu His Val Leu Gly Tyr Leu Pro Pro His Tyr Asp Ser 85 90 95 Ala Ile Gly Trp Asn Lys Asn Glu 100 Pro 105 Ser Thr Tyr Gly Lys 110 Phe Leu Asn His Gly Glu Pro Lys Leu Ala Trp Glu His Lys Glu Asp Gly Ser 115 120 125 Page 578 of 3790 Met Arg Phe Leu Phe Met Glu Ser Phe His Glu Met Met Ala Asp Phe 130 135 140 Ala Lys Ser Gin Pro Ser Leu Val Ser Asp Gly Lys Lys Ile Pro Leu 145 150 155 160 Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gin Pro Ile 165 170 175 Arg Lys Glu Glu Leu Ala Trp Leu Leu Leu Asn Phe Asn Gin Lys Arg 180 185 190 Gly Tyr Tyr Gin Leu Arg Gly Glu Glu Asp Asp Asp Asn Pro Thr Lys 195 200 205 Cys Glu Glu Tyr Tyr Glu Leu Lys Val Val Gly Ile Glu Ala Asp Glu 210 215 220 Glu Gly Lys Asn Gly Asn Thr Trp Tyr Asn Val Lys Leu Glu Asn Gly 225 230 235 240 Trp Ile Tyr Arg Arg Gin Ser Lys Ile Pro Leu Asp Asp Trp Ile Gly 245 250 255 Lys Val Arg Glu Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Ile 260 265 270 Thr Leu Lys Lys Asp Lys Asn Gly Asp Val Lys Arg Ser Phe Arg Ser 275 280 285 Pro Ser Glu Asp Asp Trp Gly Leu Arg Lys Lys Arg Thr Glu Lys Leu 290 295 300 Leu Asp Ser Ser Lys Met Thr Val Gly Ala Phe Val Tyr Asp His Leu 305 310 315 320 Leu Ala Glu Pro Ser Asp Lys Ile Arg Gly Lys Phe Ile Arg Thr Ile 325 330 335 Glu Arg Lys Tyr Tyr Lys Lys Glu Leu Tyr Ala Ile Leu Cys Glu Gin 340 345 350 Ser Lys Tyr His Glu Glu Leu Arg Ser Gly Asp Tyr Leu Asn Lys Cys 355 360 365 Ala Glu Glu Leu Tyr Lys Asn Asn Gin Pro His Arg Asn Ser Leu Leu 370 375 380 Page 579 of 3790 Thr Lys Asp Leu Ala Tyr Leu Leu Leu Glu Asp Leu Ile Phe Tyr Gin 385 390 395 400 Arg Pro Leu Lys Thr Lys Lys Ser Leu Ile Ala Glu Cys Pro Tyr Glu 405 410 415 Ala Tyr Lys Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gin Gly 420 425 430 Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gin Glu Phe Arg Leu 435 440 445 Trp Gin Phe Ile Ser Asn Leu Arg Leu Phe Asn Lys Ala Asp Asp Lys 450 455 460 Glu Val Thr Ala Asp Tyr Leu Pro Thr Gin Asp Asp Tyr Val Arg Leu 465 470 475 480 Phe Ala Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gin Glu Thr Leu Leu 485 490 495 Lys Glu Phe Phe Lys Leu Lys Lys Ile Thr Val Asn Ser Glu Lys Val 500 505 510 Phe Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 515 520 525 Cys Asn Glu Thr Arg His Glu Leu Leu Leu Ala Leu Asp Arg Ala Arg 530 535 540 Ile Asp His Ser Trp Leu Glu Lys Pro Gly Gin Glu Tyr Arg Leu Trp 545 550 555 560 His Leu Leu Tyr Ser Val Glu Ser Lys Glu Glu Thr Lys Glu Ala Leu 565 570 575 Arg Lys Leu Lys Asp Asp Asp Ala Phe Val Glu Ser Phe Leu Lys Val 580 585 590 Lys Pro Phe Lys Arg Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys 595 600 605 Lys Leu Leu Ala Val Met Arg Met Gly Ser Leu Trp Arg Glu Thr Asp 610 615 620 Ile Cys Asp Thr Thr Lys Gly Asn Ile Thr Lys Ile Leu Gin Gly Glu Page 581 of 3790 Thr Ala Ala Leu Glu Asp Val Ile Val Ser Phe Lys Asn Tyr Val 1115 1120 1125 Page 582 of 3790 Page 583 of 3790 120 1082 PRT Neisseria cinerea 120 Met Ala Ala Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp 15 10 15 Ile Gly Ile Ala Ser Val Gly Trp Ala Ile Val Glu Ile Asp Glu Glu 20 25 30 Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 35 40 45 Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 50 55 60 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 65 70 75 80 Page 584 of 3790 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gin Ala Ala Asp 85 90 95 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asp Asn Thr His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Asn Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Asn Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Asp Leu Asp Asp Thr Ala Phe Phe Lys Gly Leu Arg Page 587 of 3790 Page 588 of 3790 121 1512 PRT Fibrobacter succinogenes 121 Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Val Val Asn Ala Asp Glu Ile Thr Arg Asp Asp Gly Ser Arg Tyr 20 25 30 Leu Lys Pro Asn Gly Ile Ser Ala Ala Gly Ser Arg Ile Ile Pro Met 35 40 45 Ser Ala Asp Ile Leu Gly Asp Phe Glu Lys Gly Asn Ser Ile Ser Gin 50 55 60 Thr Ala Glu Arg Thr Arg Met Arg Met Ala Arg Arg Leu His Glu Arg 65 70 75 80 Ala Leu Leu Arg Arg Glu Arg Leu Leu Arg Val Leu Asn Leu Leu Asp 85 90 95 Phe Leu Pro Lys His Phe Ala Asp Lys Ile Asp Arg Tyr Gly Lys Phe 100 105 110 Thr Asp Asp Ser Glu Pro Lys Leu Ala Trp Arg Lys Asn Thr Glu Gly 115 120 125 Lys Tyr Glu Phe Ile Phe Gin Asp Ala Phe Asn Glu Met Leu Ala Glu 130 135 140 Phe Lys Asp Lys Gin Pro Glu Ile Val Glu Glu Gly Lys Lys Ile Pro 145 150 155 160 Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Glu Lys Ala 165 170 175 Leu Ser Lys Glu Glu Leu Ser Trp Ile Leu Leu Gin Phe Asn Gin Lys 180 185 190 Arg Gly Tyr Tyr Gin Leu Arg Gly Glu Glu Glu Glu Ile Pro Gin Asp 195 200 205 Lys Lys Ile Glu Tyr Leu Ala Gin Lys Val Val Lys Val Glu Ala Thr 210 215 220 Page 589 of 3790 Asp Gin Lys Lys Gly Asp Asp Val Trp Tyr Asn Val Tyr Leu Glu Asn 225 230 235 240 Gly Met Ile Tyr Arg Arg Thr Ser Lys Ala Pro Leu Asp Trp Glu Gly 245 250 255 Lys Val Lys Glu Phe Ile Val Thr Thr Glu Val Glu Asn Asp Gly Glu 260 265 270 Thr Pro Lys Lys Asp Lys Glu Gly Asn Ile Lys Arg Ser Phe Arg Ala 275 280 285 Pro Lys Glu Asp Asp Trp Thr Leu Leu Lys Lys Lys Thr Glu Ala Asp 290 295 300 Ile Glu Asn Ser His Lys Thr Val Gly Cys Tyr Ile Tyr Asp Ser Leu 305 310 315 320 Leu Asn Asn Pro Lys Gin Lys Ile Ile Gly Lys Leu Val Arg Thr Val 325 330 335 Glu Arg Lys Phe Tyr Lys Glu Glu Leu Thr Gin Ile Leu Lys Lys Gin 340 345 350 Val Glu Leu Ile Pro Glu Leu Arg Asp Asp Asn Leu Tyr Lys Gin Cys 355 360 365 Ile Glu Glu Leu Tyr Pro Ile Asn Glu Ala His Arg Asn Thr Ile Ala 370 375 380 Lys Thr Asp Phe Ala Asn Leu Phe Ile Asn Asp Ile Leu Phe Tyr Gin 385 390 395 400 Arg Pro Leu Lys Ser Lys Lys Ser Gin Ile Asp Asn Cys Pro Tyr Glu 405 410 415 Glu Arg Ile Phe Ile Asp Ser Lys Thr Gly Glu Lys Lys Lys Val Pro 420 425 430 Val Lys Cys Ile Ala Lys Ser Asn Pro Leu Phe Gin Glu Phe Arg Leu 435 440 445 Trp Gin Phe Ile Gin Asn Leu Arg Ile Tyr Gin Arg Glu Lys Glu Ile 450 455 460 Asp Gly Lys Leu Leu Thr Asp Ile Asp Ile Thr Ser Glu Cys Leu Lys Page 591 of 3790 Thr Glu Thr Leu Arg Thr Val Arg Asp Ile Trp Ile Gin Glu Glu Gin 725 730 735 Ile Asp Glu Ile His Leu Glu Leu Gly Arg Asp Leu Lys Asn Pro Ala 740 745 750 Asp Lys Arg Lys Lys Met Ser Glu Asn Ile Leu Lys Asn Glu Asn Thr 755 760 765 Asn Leu Arg Ile Lys Ala Met Leu Met Glu Phe Met Asn Pro Ser Met 770 775 780 Gly Ile Glu Asn Val Arg Pro Tyr Ser Pro Ser Gin Gin Asp Ile Leu 785 790 795 800 Arg Ile Tyr Glu Glu Asn Ala Leu Asp Asn Leu Thr Lys Asp Asp Lys 805 810 815 Asp Phe Asp Phe Ile Ser Lys Ile Ser Lys Gin Ala Gin Pro Ser Lys 820 825 830 Thr Asp Ile Ile Arg Tyr Lys Cys Trp Leu Glu Gin Lys Tyr Arg Ser 835 840 845 Pro Tyr Thr Gly Lys Thr Ile Ser Leu Ser Lys Leu Phe Thr Pro Ala 850 855 860 Tyr Glu Ile Glu His Val Ile Pro Gin Ser Leu Tyr Phe Asp Asp Ser 865 870 875 880 Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Lys Leu Lys Asp 885 890 895 Arg Gin Leu Gly Tyr Lys Phe Ile Ala Glu His His Gly Glu Lys Val 900 905 910 Gin Leu Ser Gin Gly Glu Val 915 Val 920 Glu Ile Leu Ser Val Asp Ala Tyr 925 Glu Lys Phe Val Lys Glu Asn Tyr Ala Asn Asn Arg Ile Lys Met Lys 930 935 940 Lys Leu Leu Met Glu 945 Ser 950 Ile Pro Asp Glu Phe 955 Ile Glu Arg Gin Leu 960 Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Gly Leu Leu Ser Asn 965 970 975 Page 592 of 3790 Ile Val Arg Glu Lys Ile Asp Asp Glu Asn Tyr Glu Pro Glu Ala Val 980 985 990 Ser Lys Asn Leu Ile Ser Cys Asn Gly Ala Ile Thr Asp Arg Leu Lys 995 1000 1005 Page 593 of 3790 Lys Arg Ile Tyr Lys Val Val Ser Phe Thr Asn Asn Arg Leu Tyr 122 1259 PRT Streptobacillus moniliformis 122 Met Lys Tyr Ile Leu Gly Leu Asp Leu Gly Val Ala Ser Ile Gly Trp 15 10 15 Ala Val Thr Glu Ile Asn Glu Lys Gly Glu Pro Val Gly Leu Ile Asp 20 25 30 Ala Asn Ser Val Ile Phe Lys Pro Leu Asp Asn Asp Lys Gly Lys Leu 35 40 45 Tyr Asn Val Glu Arg Arg Asp Lys Arg Gly Ser Arg Arg Ile Leu Arg 50 55 60 Arg Lys Lys His Arg Val Glu Arg Thr Lys Met Leu Leu Val Asn Ser 65 70 75 80 Ser Phe Leu Thr Asn Glu Glu Ile Asp Asn Leu Tyr Val Gly Lys Leu 85 90 95 Asp Asn Ile Tyr Glu Val Arg Leu Lys Gly Leu Lys Glu Gin Leu Ser 100 105 110 Lys Asn Glu Ile Ala Arg Leu Met Ile Tyr Tyr Cys Lys Asn Arg Gly 115 120 125 Phe Lys Ser Asn Arg Lys Thr Glu Asp Leu Glu Ile Leu Lys Ser Leu 130 135 140 Gly Glu Lys Ile Ser Glu Lys Asp Ser Asp Glu Lys Lys Leu Lys Pro Page 596 of 3790 Lys Ser Lys Phe Lys Lys Asn Asn Ile Asp Glu Asn Arg Ile Lys Glu 405 410 415 Leu Gly Gly Ile Tyr Phe Leu Asp Leu Val Ala Glu Leu Leu Thr Tyr 420 425 430 Ser Lys Thr Asp Glu Lys Leu Glu Tyr Phe Val Glu Asn Val Glu Arg 435 440 445 Tyr Ser Leu Phe Lys Glu Gin Arg Asp Ile Val Glu Ile Ile Lys Thr 450 455 460 Phe Pro Asn Tyr Thr Lys Asn Gly Asn Leu Ser Leu Ser Leu Val Arg 465 470 475 480 Glu Leu Asn Lys Leu Leu Met Glu Gly His Asp Tyr Glu Ser Ser Leu 485 490 495 Ser Ser Leu Asn Tyr Tyr Ile Asp Thr Asp Val Asp Trp Glu Lys Phe 500 505 510 Pro Thr Ile Ser Glu Ile Glu Asp Ser Leu Ser Thr Lys Ile Thr Asn 515 520 525 Pro Asn Val Lys His Ile Leu Val Ile Leu Arg Lys Leu Tyr Asn Thr 530 535 540 Leu Leu Phe Lys Tyr Gly Arg Pro Glu Lys Val His Leu Glu Leu Ser 545 550 555 560 Arg Asp Phe Ser Asn Asp Phe Ser Thr Arg Asn Lys Ile Gin Lys Glu 565 570 575 Gin Leu Glu Asn Lys Val Arg Arg Glu Val Ala Ala Phe Glu Met Tyr 580 585 590 Gly Ala Asn Lys Asp Ile Val Ala Gly Lys Asp Arg Leu Ser Asn Asp 595 600 605 Asp Phe Val Arg Ile Lys Leu Trp Glu Glu Gin Asn Lys Val Cys Met 610 615 620 Tyr Ser Gly Arg Thr Ile Glu Lys Tyr Gin Leu Thr Ser Ala Glu Val 625 630 635 640 Gin Ile Asp His Ile Leu Pro Tyr Ser Lys Ser Phe Asp Asn Ser Tyr 645 650 655 Page 597 of 3790 Ser Asn Lys Val Leu Val Phe Ser Asn Glu Asn Gin Asp Lys Lys Glu 660 665 670 Arg Thr Pro Tyr Gin Trp Leu Lys Gly Thr Glu Lys Trp Asn Glu Phe 675 680 685 Lys Gin Arg Val Arg Leu Asn Leu Asn Ile Ser Asn Lys Lys Lys Glu 690 695 700 Asn Leu Leu Phe Glu Asp Glu Val Val Asn Asn Glu Phe Leu Glu Arg 705 710 715 720 Glu Leu His Ala Thr Ser Tyr Ser Ser Arg Leu Ala Leu Asn Ile Phe 725 730 735 Gin Arg Leu Ile Pro Val Ser Asp Glu Asp Lys Tyr Asp Glu His Gly 740 745 750 Asn Glu Lys Val Lys Tyr Leu Tyr Asn Arg Asn Val Ile Ala Phe Gin 755 760 765 Gly Lys Met Thr Ser Met Leu Arg Asn Leu Tyr Ser Leu Asn Lys Tyr 770 775 780 Thr His Ser Phe Glu Ser Asp Thr Leu Asp Ile Asp Asn Lys Ala Phe 785 790 795 800 Ile Leu Lys Glu Phe Glu Ile Asn Lys Asp Asn Leu Lys Met Thr Ala 805 810 815 Tyr Asn Val Asn Thr Gly Leu Glu Ile Thr Ser Glu Thr Lys Val Glu 820 825 830 Lys Asn Lys Ser Gly Glu Phe Lys Thr Ile Lys Asp Glu Leu Leu Lys 835 840 845 Lys Glu Leu Asp Lys Lys Glu Asn Leu Ile Glu Ile Ser Asp Tyr Phe 850 855 860 Lys Asp Lys Val Leu Phe Asp Leu Lys Ile Val Asp Phe Glu Glu Ile 865 870 875 880 Asp Thr Val Glu Pro Glu Ile Ile Ser Ile Leu Tyr Lys Met Ile Thr 885 890 895 Ala Leu Lys Glu Glu Val Tyr Ser Lys Asn Arg Glu Asn His Leu His 900 905 910 Page 598 of 3790 Arg Tyr Lys Tyr Asn Leu Leu Lys Ser Glu Lys Asp Val Asn Ile Val Gly Phe Ala Ala Val Glu Glu Asp Asp Ser Gly Ser Pro 20 25 30 Thr Arg Phe Leu Asn 35 Thr Met Val Val Ile His Asp 40 Ser Gly Val Asp 45 Pro Glu Gin Lys Lys 50 Tyr Ala Ile Thr Arg Leu Ala 55 Ser Ala Gly 60 Thr Ala Arg Arg Thr Arg Arg Leu 65 Tyr Arg 70 Thr Arg Arg Gin Arg 75 Leu Arg Glu Leu Asp Asp Phe Ile Ser Asn Glu Leu Gly 85 Tyr Pro 90 Leu Val Asn Leu Glu Asn Phe Ala Asp Pro Tyr Glu Pro Trp Lys Val Arg Ala Asp Leu Ala Page 602 of 3790 Pro Phe Ala Val Trp Ala Gly Lys Ala Ser Asn Phe Asp Val Ser Ile 610 615 620 Asp Asp Ala Val Ser Arg Val Lys Gin Trp Gin Arg Ser Gin Asn Glu 625 630 635 640 Gly Val Arg Glu Phe Arg Ala Phe Gin Asn Glu Val Ile Ser Arg Leu 645 650 655 Leu Lys Thr Thr Glu Asp Pro Glu Ile Asp Ser Arg Ser Leu Glu Ser 660 665 670 Val Ala Trp Met Ala Arg Glu Leu His His Arg Val Glu Tyr Tyr Phe 675 680 685 Gin Ser Lys Gly Ala Gin Thr Gin Val Ser Val Tyr Arg Gly Ala Val 690 695 700 Thr Ala Gin Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 705 710 715 720 Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 725 730 735 Asp Ala Ala Thr Ile Ala Leu Met Thr Pro Gly Ile Ser Thr Thr Leu 740 745 750 Ser Glu Lys Asn Asn Leu Arg Asp Ala Gin Lys Phe Thr Gly Gin Ser 755 760 765 Glu Thr Trp Lys Asp Tyr Cys Gly Arg Thr Glu Thr Ala Arg Lys His 770 775 780 Phe Ala Val Trp Lys Ser Asn Met Glu Arg Leu Thr Asp Leu Phe Asn 785 790 795 800 Asp Lys Leu Glu Asn Asp Ala Ile Pro Val Val Gin Pro Leu Arg Leu 805 810 815 Arg Leu Ser Asn Ser Lys Ala His Asp Asp Gly Ile Gly Lys Leu Asp 820 825 830 Ser Lys Lys Leu Gly 835 Ser Val Trp Ser Leu Ala Asp 840 Ile Asp Arg Ala 845 Ala Thr Pro Gin Ile Trp Thr Ala Leu Thr Arg Cys Asp Asp Phe Asp 850 855 860 Page 603 of 3790 124 Page 604 of 3790 872 PRT Candidatus Parvarchaeum 124 Met Leu Gly Ser Ser Arg Tyr Leu Arg Tyr Asn Leu Thr Ser Phe Glu 15 10 15 Gly Lys Glu Pro Phe Leu Ile Met Gly Tyr Tyr Lys Glu Tyr Asn Lys 20 25 30 Glu Leu Ser Ser Lys Ala Gin Lys Glu Phe Asn Asp Gin Ile Ser Glu 35 40 45 Phe Asn Ser Tyr Tyr Lys Leu Gly Ile Asp Leu Gly Asp Lys Thr Gly 50 55 60 Ile Ala Ile Val Lys Gly Asn Lys Ile Ile Leu Ala Lys Thr Leu Ile 65 70 75 80 Asp Leu His Ser Gin Lys Leu Asp Lys Arg Arg Glu Ala Arg Arg Asn 85 90 95 Arg Arg Thr Arg Leu Ser Arg Lys Lys Arg Leu Ala Arg Leu Arg Ser 100 105 110 Trp Val Met Arg Gin Lys Val Gly Asn Gin Arg Leu Pro Asp Pro Tyr 115 120 125 Lys Ile Met His Asp Asn Lys Tyr Trp Ser Ile Tyr Asn Lys Ser Asn 130 135 140 Ser Ala Asn Lys Lys Asn Trp Ile Asp Leu Leu Ile His Ser Asn Ser 145 150 155 160 Leu Ser Ala Asp Asp Phe Val Arg Gly Leu Thr Ile Ile Phe Arg Lys 165 170 175 Arg Gly Tyr Leu Ala Phe Lys Tyr Leu Ser Arg Leu Ser Asp Lys Glu 180 185 190 Phe Glu Lys Tyr Ile Asp Asn Leu Lys Pro Pro Ile Ser Lys Tyr Glu 195 200 205 Tyr Asp Glu Asp Leu Glu Glu Leu Ser Ser Arg Val Glu Asn Gly Glu 210 215 220 Ile Glu Glu Lys Lys Phe Glu Gly Leu Lys Asn Lys Leu Asp Lys Ile Page 606 of 3790 Glu Lys Ser Phe Glu Thr Leu Lys Glu Lys Leu Ala Lys Glu Thr Gly 485 490 495 Gly Ile Asp Ile Tyr Thr Gly Glu Lys Leu Lys Lys Asp Phe Glu Ile 500 505 510 Glu His Ile Phe Pro Arg Ala Arg Met Gly Pro Ser Ile Arg Glu Asn 515 520 525 Glu Val Ala Ser Asn Leu Glu Thr Asn Lys Glu Lys Ala Asp Arg Thr 530 535 540 Pro Trp Glu Trp Phe Gly Gin Asp Glu Lys Arg Trp Ser Glu Phe Glu 545 550 555 560 Lys Arg Val Thr Ser Leu Tyr Ser Lys Lys Lys Ile Ser Glu Arg Lys 565 570 575 Arg Glu Ile Leu Leu Asn Lys Ser Asn Glu Tyr Pro Gly Leu Asn Pro 580 585 590 Thr Glu Leu Ser Arg Ile Pro Ser Thr Leu Ser Asp Phe Val Glu Ser 595 600 605 Ile Arg Lys Met Phe Val Lys Tyr Gly Tyr Glu Glu Pro Gin Thr Leu 610 615 620 Val Gin Lys Gly Lys Pro Ile Ile Gin Val Val Arg Gly Arg Asp Thr 625 630 635 640 Gin Ala Leu Arg Trp Arg Trp His Ala Leu Asp Ser Asn Ile Ile Pro 645 650 655 Glu Lys Asp Arg Lys Ser Ser Phe Asn His Ala Glu Asp Ala Val Ile 660 665 670 Ala Ala Cys Met Pro Pro Tyr Tyr Leu Arg Gin Lys Ile Phe Arg Glu 675 680 685 Glu Ala Lys Ile Lys Arg Lys Val Ser Asn Lys Glu Lys Glu Val Thr 690 695 700 Arg Pro Asp Met Pro Thr Lys Lys Ile Ala Pro Asn Trp Ser Glu Phe 705 710 715 720 Met Lys Thr Arg Asn Glu Pro Val Ile Glu Val Ile Gly Lys Val Lys 725 730 735 Page 607 of 3790 Pro Ser Trp Lys Asn Ser Ile Met Asp Gin Thr Phe Tyr Lys Tyr Leu 740 745 750 Leu Lys Pro Phe Lys Asp Asn Leu Ile Lys Ile Pro Asn Val Lys Asn 755 760 765 Thr Tyr Lys Trp Ile Gly Val Asn Gly Gin Thr Asp Ser Leu Ser Leu 770 775 780 Pro Ser Lys Val Leu Ser Ile Ser Asn Lys Lys Val Asp Ser Ser Thr 785 790 795 800 Val Leu Leu Val His Asp Lys Lys Gly Gly Lys Arg Asn Trp Val Pro 805 810 815 Lys Ser Ile Gly Gly Leu Leu Val Tyr Ile Thr Pro Lys Asp Gly Pro 820 825 830 Lys Arg Ile Val Gin Val Lys Pro Ala Thr Gin Gly Leu Leu Ile Tyr 835 840 845 Arg Asn Glu Asp Gly Arg Val Asp Ala Val Arg Glu Phe Ile Asn Pro 850 855 860 Val Ile Glu Met Tyr Asn Asn Gly 865 870 125 1229 PRT Pediococcus acidilactici 125 Met Gly Asp Arg Lys Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser Ser 15 10 15 Ile Gly Phe Ala Ala Val Asp Glu Asn Asn Gin Pro Ile Arg Val Lys 20 25 30 Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala 35 40 45 Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 50 55 60 Arg Trp Arg Ile Asn Leu Leu Asn Glu Ile Phe Asp Ala His Leu Ala 65 70 75 80 Page 608 of 3790 Glu Val Asp Pro Thr Phe Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser 85 90 95 Asn Leu Asp Pro Lys Lys Ser Phe Gin Gly Ser Leu Leu Phe Pro Glu 100 105 110 Arg Lys Asp Tyr Gin Phe Tyr Glu Glu Tyr Pro Thr Ile Tyr His Leu 115 120 125 Arg Lys Ala Leu Met Glu Lys Asp Arg Lys Phe Asp Ile Arg Glu Ile 130 135 140 Tyr Leu Ala Val His His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Asn 145 150 155 160 Gly Thr Pro Met Arg Ser Phe Lys Val Glu Asn Ile Glu Leu Asn Thr 165 170 175 Leu Phe Asp Gin Leu Asn Gin Leu Tyr Ala Glu Ile Val Pro Asp Asn 180 185 190 Glu Leu Ala Phe Asp Leu Ala Gin Val Ala Asp Val Lys Asp Val Leu 195 200 205 Ser Ser Thr Thr Ile Tyr Lys Met Asp Lys Lys Lys Gin Leu Val Lys 210 215 220 Met Met Leu Leu Pro Ala Ser Asn Lys Ala Leu Gin Ser Glu Asn Lys 225 230 235 240 Lys Ile Val Thr Gin Phe Val Asn Ala Ile Leu Asn Tyr Lys Phe Lys 245 250 255 Leu Asp Val Leu Leu Gin Val Glu Thr Asp Ala Asp Trp Ser Leu Lys 260 265 270 Leu Asn Asp Glu Gly Ala Asp Asp Lys Leu Glu Glu Phe Thr Gly Asp 275 280 285 Leu Asp Glu Asn Arg Leu Glu Ile Ile Asp Leu Leu Gin Arg Leu His 290 295 300 Asn Trp Phe Ser Leu Asn Glu Ile Thr Lys Asp Gly Asn Ser Leu Ser 305 310 315 320 Ala Ala Met Val Glu Lys Tyr Glu Asn His His His His Leu Gly Leu 325 330 335 Page 609 of 3790 Leu Lys Lys Val Ile Glu Asn His Pro Asp Ala Lys Lys Ala Lys Ala 340 345 350 Leu Lys Glu Thr Tyr Thr Ala Tyr Val Gly Lys Thr Asp Asp Lys Thr 355 360 365 Gin Asn Gin Asp Asp Phe Tyr Lys Ala Val Glu Lys Asn Leu Asp Asp 370 375 380 Ser Pro Asp Ala Lys Gly Ile Lys Arg Leu Ile Gin Leu Asp Gin Phe 385 390 395 400 Met Pro Lys Gin Arg Thr Gly Gin Asn Gly Ala Ile Pro His Gin Leu 405 410 415 His Gin Gin Glu Leu Asp Gin Ile Ile Glu Lys Gin Ser Lys Tyr Tyr 420 425 430 Pro Phe Leu Ala Glu Pro Asn Pro Asn Val Lys Arg Arg Lys Asp Ala 435 440 445 Pro Tyr Lys Leu Asp Glu Leu Ile Ala Phe Lys Ile Pro Tyr Tyr Val 450 455 460 Gly Pro Leu Val Thr Pro Glu Glu Gin Ala Gin Asn Lys Glu Asn Val 465 470 475 480 Phe Ala Trp Met Lys Arg Lys Ala Ala Gly Pro Ile Thr Pro Trp Asn 485 490 495 Phe Asp Glu Lys Val Asp Arg Met Glu Ser Ala Asn Arg Phe Ile Arg 500 505 510 Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro 515 520 525 Ala Glu Ser Met Ile Tyr Gin Lys Phe Val Val Leu Asn Glu Leu Asn 530 535 540 Asn Leu Lys Ile Asn Gly Arg His Leu Ser Leu Lys Asp Lys Gin Asp 545 550 555 560 Val Tyr Asn Asp Leu Phe Lys Gin Gin Lys Thr Val Ser Ile Lys Ala 565 570 575 Leu Gin Asn Tyr Tyr Val Thr Lys Lys Lys Ala Ala Thr Ala Pro Thr Page 611 of 3790 Page 612 of 3790 126 1398 PRT Veillonella parvula 126 Page 613 of 3790 Val Ala Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 65 70 75 80 Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 85 90 95 Gin Val Asp Pro Thr Phe Phe Met Arg Leu Arg Glu Ser Lys Tyr His 100 105 110 Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 115 120 125 Asp Lys Asn Tyr Asn Asp Gin Asp Tyr Phe Lys Glu Tyr Pro Thr Val 130 135 140 Tyr His Leu Arg Ser Glu Leu Met Lys Ser Gly Thr Asp Asp Ile Arg 145 150 155 160 Lys Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly Asn Phe 165 170 175 Leu Tyr Glu Gly Ala Thr Phe Asp Ser Asn Ala Ser Thr Leu Asp Asp 180 185 190 Val Ile Lys Gin Ala Leu Glu Asn Ile Thr Phe Asn Cys Phe Asp Cys 195 200 205 Asn Ser Ala Ile Ser Ser Ile Gly Gin Ile Leu Met Glu Ala Gly Lys 210 215 220 Thr Lys Ser Asp Lys Ala Lys Ala Ile Glu His Leu Val Asp Thr Tyr 225 230 235 240 Ile Ala Thr Asp Thr Val Asp Thr Ser Ser Lys Thr Gin Lys Asp Gin 245 250 255 Val Lys Glu Asp Lys Lys Arg Leu Lys Ala Phe Ala Asn Leu Val Leu 260 265 270 Gly Leu Asn Ala Ser Leu Ile Asp Leu Phe Gly Ser Val Glu Glu Leu 275 280 285 Glu Glu Asp Leu Lys Lys Leu Gin Ile Thr Gly Asp Thr Tyr Asp Asp 290 295 300 Lys Arg Asp Glu Leu Ala Lys Ala Trp Ser Asp Glu Ile Tyr Ile Ile 305 310 315 320 Page 614 of 3790 Asp Asp Cys Lys Ser Val Tyr Asp Ala Ile Ile Leu Leu Ser Ile Lys 325 330 335 Glu Pro Gly Leu Thr Ile Ser Glu Ser Lys Val Lys Ala Phe Asn Lys 340 345 350 His Lys Asp Asp Leu Ala Ile Leu Lys Ser Leu Leu Lys Ser Asp Arg 355 360 365 Ser Ile Tyr Asn Thr Met Phe Lys Val Asp Glu Lys Gly Leu His Asn 370 375 380 Tyr Val His Tyr Ile Lys Gin Gly Arg Thr Glu Glu Thr Ser Cys Asn 385 390 395 400 Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu Gly Leu Ser 405 410 415 Asp Ser Lys Asp Lys Glu Tyr Ile Leu Ser Gin Ile Glu Leu Gin Ile 420 425 430 Leu Leu Pro Leu Gin Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gin 435 440 445 Leu His Leu Glu Glu Leu Lys Ala Ile Leu Ala Lys Cys Gly Pro Lys 450 455 460 Phe Pro Phe Leu Asn Glu Val Ala Asp Gly Phe Ser Val Ala Glu Lys 465 470 475 480 Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 485 490 495 Asn Thr His His Asn Val Asp Asn Gly Gly Phe Ala Trp Ala Val Arg 500 505 510 Lys Ala Ser Gly Arg Val Thr Pro Trp Asn Phe Asp Asp Lys Ile Asp 515 520 525 Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 530 535 540 Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 545 550 555 560 Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly Page 616 of 3790 Page 617 of 3790 Page 618 of 3790 127 1485 PRT Prevotella bivia 127 Page 619 of 3790 Lys Met Arg Phe Leu Phe Met Asp Ser Phe His Asp Met Leu Ser Glu 130 135 140 Phe Ser Glu Lys His Pro Glu Leu Leu Ala Asn Gly Lys Lys Ile Pro 145 150 155 160 Leu Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Tyr Lys Ala 165 170 175 Ile Thr Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys 180 185 190 Arg Gly Tyr Tyr Gin Leu Arg Gly Glu Glu Asp Arg Asp Ser Glu Ala 195 200 205 Asn Lys Lys Glu Tyr Leu Glu Leu Lys Val Ile Gly Val Glu Ala Thr 210 215 220 Gly Glu Lys Lys Gly Asn Asp Ile Trp Tyr Asn Ile His Leu Glu Asn 225 230 235 240 Gly Trp Ile Tyr Arg Arg Ser Ser Lys Asn Pro Leu Asn Asp Trp Leu 245 250 255 Gly Lys Val Lys Ser Phe Ile Val Thr Thr Asp Leu Asp Ala Asp Gly 260 265 270 Asn Pro Lys Lys Asp Lys Asp Gly Asn Ile Lys Arg Ser Phe Arg Ala 275 280 285 Pro Ser Glu Gly Asp Trp Thr Leu Ile Lys Lys Arg Thr Glu Ser Leu 290 295 300 Leu Glu Asn Ser Gly Gin Thr Val Gly Gin Phe Ile Tyr Asn His Ile 305 310 315 320 Leu Glu Glu Pro Ser Ala Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 325 330 335 Glu Arg Lys Tyr Tyr Lys Asp Glu Leu Lys Ala Ile Leu Glu Lys Gin 340 345 350 Lys Glu Phe His His Glu Leu Ser Ser Glu Ser Leu Leu Thr Glu Cys 355 360 365 Ala Lys Glu Leu Tyr Lys Arg Asn Ile Ala His Gin Glu Val Leu Leu Page 621 of 3790 Ile Lys Gin Val Gly Ala Glu Ile Glu Lys Thr Ile Glu Gly Glu Leu 625 630 635 640 Pro Asp Tyr Val Leu Gin Arg Leu Glu Lys Ser Gin His Asn Tyr Asn 645 650 655 Lys Ile Ser Asp Phe Ser Gly Leu Pro Leu Trp Leu Ala Ser Tyr Ile 660 665 670 Ile Tyr Gly Arg His Ser Glu Ala Lys Glu Ile Ile His Trp Asp Asn 675 680 685 Pro Glu Ser Met Met Ala Tyr Ile Lys Asp Phe Arg Gin His Ser Met 690 695 700 Arg Asn Pro Ile Val Glu Gin Cys Val Leu Glu Thr Leu Arg Thr Val 705 710 715 720 His Asp Ile Trp Lys Glu Ile Gly His Ile Asp Glu Ile His Ile Glu 725 730 735 Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Gin Arg Lys Ala Ile Thr 740 745 750 Gin Asn Val Leu His Asn Gin Asn Thr Asn Ile Arg Ile Lys Leu Leu 755 760 765 Leu Gin Glu Leu Lys Asn Asp Asn Asn Ile Thr Gly Val Arg Pro Tyr 770 775 780 Ser Pro Met Gin Gin Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala Leu 785 790 795 800 Gin Gly Leu Thr Lys Glu Asp Lys Asp Tyr Asn Asp Ile Leu Lys Ile 805 810 815 Ser Gin Thr Ala Gin Pro Thr Ser Asn Glu Leu Thr Arg Tyr Lys Leu 820 825 830 Trp Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ala Ile Ser 835 840 845 Leu Ser Lys Leu Phe Thr Ser Ala Tyr Gin Ile Glu His Val Ile Pro 850 855 860 Gin Ser Arg Tyr Phe Asp Asp Ser Leu Ser Asn Lys Val Ile Cys Glu 865 870 875 880 Page 622 of 3790 Tyr Ala Leu Lys Asp Ile Ile Val Thr Phe Lys Asn Tyr Val Arg 1115 1120 1125 Page 623 of 3790 Lys Glu Gly Lys Arg Asn Tyr Asp Thr Ile Pro Leu Asn Ile Ala 128 1218 PRT Prevotella buccalis 128 Met Asn Lys Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Gly 15 10 15 Trp Ala Val Val Asp Trp Asp Glu His Ala Gin Ser Tyr Glu 30 Leu Ile Lys Tyr Gly Asp Val 35 Ile Phe Gin Glu Gly Val 40 Lys Ile Glu Lys Gly 45 Ile Glu Ser 50 Ser Lys Ala Ala 55 Glu Arg Ser Gly Tyr Lys Ala 60 Ile Arg Lys Gin Tyr Phe Arg Arg Arg 70 Leu Arg Lys Ile Gin Val 75 Leu Lys Val 80 Leu Val Lys Tyr His Leu Cys Pro Tyr Leu Ser Asp Asp Asp Leu Arg Page 626 of 3790 Gly Lys Lys Asn Tyr Ala Trp Ile His Asp Lys Glu Glu Arg Ala Tyr 340 345 350 Lys Phe Asn Tyr Arg Met Thr Gin Gly Val Pro Gly Cys Pro Thr Thr 355 360 365 Ala Gin Leu Lys Ser Ile Phe Gly Asp Asp Trp Lys Thr Gly Ile Ala 370 375 380 Glu Thr Tyr Thr Leu Ile Gin Lys Lys Asn Gly Ser Lys Ser Leu Gin 385 390 395 400 Glu Met Val Asp Asp Val Trp Asn Val Leu Tyr Ser Phe Ser Ser Val 405 410 415 Glu Lys Leu Lys Glu Phe Ala His His Lys Leu Gin Leu Asp Glu Glu 420 425 430 Asn Ala Glu Lys Phe Ala Lys Ile Lys Leu Ser His Ser Phe Ala Ala 435 440 445 Leu Ser Leu Lys Ala Ile Arg Lys Phe Leu Pro Phe Leu Arg Lys Gly 450 455 460 Met Tyr Tyr Thr His Ala Ser Phe Phe Ala Asn Ile Pro Thr Ile Val 465 470 475 480 Gly Lys Glu Ile Trp Asn Asn Glu Gin Ser Arg Lys Tyr Ile Met Glu 485 490 495 Asn Val Gly Glu Leu Val Phe Asn Tyr Gin Pro Lys His Arg Asp Val 500 505 510 Gin Gly Thr Ile Glu Met Leu Ile Lys Asp Phe Leu Ala Asn Asn Phe 515 520 525 Glu Leu Pro Ala Gly Ala Thr Asp Lys Leu Tyr His Pro Ser Met Ile 530 535 540 Glu Thr Tyr Pro His Ala Leu Arg Asn Glu Phe Gly Ile Leu Gin Leu 545 550 555 560 Gly Ser Pro Arg Thr Asn Ala Ile Arg Asn Pro Met Ala Met Arg Ser 565 570 575 Leu His Val Leu Arg Arg Val Val Asn Gin Leu Leu Lys Glu Ser Ile 580 585 590 Page 627 of 3790 Ile Asp Glu Asn Thr Glu Val His Val Glu Tyr Ala Arg Glu Leu Asn 595 600 605 Asp Ala Asn Lys Arg Arg Ala Ile Ala Asp Arg Gin Lys Glu Gin Asp 610 615 620 Lys Gin His Lys Lys Tyr Gly Asp Glu Ile Arg Lys Leu Tyr Lys Glu 625 630 635 640 Glu Thr Gly Lys Asp Ile Glu Pro Thr Gin Thr Asp Val Leu Lys Phe 645 650 655 Gin Leu Trp Glu Glu Gin Asn His Tyr Cys Leu Tyr Thr Gly Glu Gin 660 665 670 Ile Gly Ile Thr Asp Phe Ile Gly Ser Asn Pro Lys Phe Asp Ile Glu 675 680 685 His Thr Ile Pro Gin Ser Val Gly Gly Asp Ser Thr Gin Met Asn Leu 690 695 700 Thr Leu Cys Asp Asn Arg Phe Asn Arg Glu Val Lys Lys Ala Lys Leu 705 710 715 720 Pro Thr Glu Leu Ala Asn His Glu Glu Ile Leu Thr Arg Ile Glu Pro 725 730 735 Trp Lys Asn Lys Tyr Glu Gin Leu Val Lys Glu Arg Asp Lys Gin Arg 740 745 750 Thr Phe Ala Gly Met Asp Lys Ala Val Lys Asp Ile Arg Ile Gin Lys 755 760 765 Arg His Lys Leu Gin Met Glu Ile Asp Tyr Trp Arg Gly Lys Tyr Glu 770 775 780 Arg Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gin Gly 785 790 795 800 Thr Gly Ile Gly Leu Ile Ser Arg Tyr Ala Gly Leu Tyr Leu Lys Ser 805 810 815 Leu Phe His Gin Ala Asp Ser Arg Asn Lys Ser Asn Val Tyr Val Val 820 825 830 Lys Gly Val Ala Thr Ala Glu Phe Arg Lys Met Trp Gly Leu Gin Ser 835 840 845 Page 628 of 3790 Ser Tyr Ile Glu Ala Ala Lys Tyr Tyr Lys Arg Ser Gin Asp Arg 129 1218 PRT Prevotella timonensis 129 Met Asn Lys Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Gly 15 10 15 Trp Ala Val Val Asp Trp Asp Glu His Ala Gin Ser Tyr Glu 30 Leu Ile Lys Tyr Gly Asp Val 35 Ile Phe Gin Glu Gly Val 40 Lys Ile Glu Lys Gly 45 Ile Glu Ser 50 Ser Lys Ala Ala 55 Glu Arg Ser Gly Tyr Lys Ala 60 Ile Arg Lys Gin Tyr Phe Arg Arg Arg 70 Leu Arg Lys Ile Gin Val 75 Leu Lys Val 80 Leu Val Lys Tyr His Leu Cys Pro Tyr Leu Ser Asp Asp Asp Leu Arg Page 631 of 3790 Gly Lys Lys Asn Tyr Ala Trp Ile His Asp Lys Glu Glu Arg Ala Tyr 340 345 350 Lys Phe Asn Tyr Arg Met Thr Gin Gly Val Pro Gly Cys Pro Thr Ile 355 360 365 Ala Gin Leu Lys Ser Ile Phe Gly Asp Asp Trp Lys Thr Gly Ile Ala 370 375 380 Glu Thr Tyr Thr Leu Ile Gin Lys Lys Asn Gly Ser Lys Ser Leu Gin 385 390 395 400 Glu Met Val Asp Asp Val Trp Asn Val Leu Tyr Ser Phe Ser Ser Val 405 410 415 Glu Lys Leu Lys Glu Phe Ala His His Lys Leu Gin Leu Asp Glu Glu 420 425 430 Ser Ala Glu Lys Phe Ala Lys Ile Lys Leu Ser His Ser Phe Ala Ala 435 440 445 Leu Ser Leu Lys Ala Ile Arg Lys Phe Leu Pro Phe Leu Arg Lys Gly 450 455 460 Met Tyr Tyr Thr His Ala Ser Phe Phe Ala Asn Ile Pro Thr Ile Val 465 470 475 480 Gly Lys Glu Ile Trp Asn Lys Glu Gin Asn Arg Lys Tyr Ile Met Glu 485 490 495 Asn Val Gly Glu Leu Val Phe Asn Tyr Gin Pro Lys His Arg Glu Val 500 505 510 Gin Gly Thr Ile Glu Met Leu Ile Lys Asp Phe Leu Ala Asn Asn Phe 515 520 525 Glu Leu Pro Ala Gly Ala Thr Asp Lys Leu Tyr His Pro Ser Met Ile 530 535 540 Glu Thr Tyr Pro Asn Ala Gin Arg Asn Glu Phe Gly Ile Leu Gin Leu 545 550 555 560 Gly Ser Pro Arg Thr Asn Ala Ile Arg Asn Pro Met Ala Met Arg Ser 565 570 575 Leu His Ile Leu Arg Arg Val Val Asn Gin Leu Leu Lys Glu Ser Ile 580 585 590 Page 632 of 3790 Ile Asp Glu Asn Thr Glu Val His Val Glu Tyr Ala Arg Glu Leu Asn 595 600 605 Asp Ala Asn Lys Arg Arg Ala Ile Ala Asp Arg Gin Lys Glu Gin Asp 610 615 620 Lys Gin His Lys Lys Tyr Gly Asp Glu Ile Arg Lys Leu Tyr Lys Glu 625 630 635 640 Glu Thr Gly Lys Asp Ile Glu Pro Thr Gin Thr Asp Val Leu Lys Phe 645 650 655 Gin Leu Trp Glu Glu Gin Asn His His Cys Leu Tyr Thr Gly Glu Gin 660 665 670 Ile Gly Ile Thr Asp Phe Ile Gly Ser Asn Pro Lys Phe Asp Ile Glu 675 680 685 His Thr Ile Pro Gin Ser Val Gly Gly Asp Ser Thr Gin Met Asn Leu 690 695 700 Thr Leu Cys Asp Asn Arg Phe Asn Arg Glu Val Lys Lys Ala Lys Leu 705 710 715 720 Pro Thr Glu Leu Ala Asn His Glu Glu Ile Leu Thr Arg Ile Glu Pro 725 730 735 Trp Lys Asn Lys Tyr Glu Gin Leu Val Lys Glu Arg Asp Lys Gin Arg 740 745 750 Thr Phe Ala Gly Met Asp Lys Ala Val Lys Asp Ile Arg Ile Gin Lys 755 760 765 Arg His Lys Leu Gin Met Glu Ile Asp Tyr Trp Arg Gly Lys Tyr Glu 770 775 780 Arg Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gin Gly 785 790 795 800 Thr Gly Ile Gly Leu Ile Ser Arg Tyr Ala Gly Leu Tyr Leu Lys Ser 805 810 815 Leu Phe His Gin Ala Asp Ser Arg Asn Lys Ser Asn Val Tyr Val Val 820 825 830 Lys Gly Val Ala Thr Ala Glu Phe Arg Lys Met Trp Gly Leu Gin Ser 835 840 845 Page 633 of 3790 Ser Tyr Ile Glu Ala Ala Lys Tyr Tyr Lys Arg Ser Gin Asp Arg 130 1487 PRT Prevotella timonensis 130 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Val Gly Trp 15 10 15 Ala Leu Val Lys Val 20 Glu Glu Asn Gly Asn 25 Pro Ile Gly Ser 30 Ile Lys Met Gly Ser Arg 35 Ile Ile Pro Met 40 Ser Gin Asp Ile Leu Gly 45 Ser Phe Glu Lys 50 Gly Asp Thr Val Ser Gin 55 Thr Ala Gin Arg 60 Thr Leu Tyr Arg Gly Lys Arg Arg Leu 65 Ile Glu Arg His Val 70 Leu Arg Arg Glu Arg 75 Leu Cys Arg Val Leu His Ile Met Asn Phe Leu Pro Ala His Phe Asp Arg 565 570 575 Lys Ala Leu Arg Lys Leu Tyr Asp Asp Asp Lys Phe Val Thr Ser Phe 580 585 590 Page 637 of 3790 Leu Lys Ile Lys Pro Phe Asn Lys Cys Tyr Gly Ala Tyr Ser Glu Lys 595 600 605 Ala Ile Lys Arg Leu Leu Thr Leu Met Arg Met Gly Lys Ala Trp Asn 610 615 620 Glu Gin Ala Ile Asp Ala Lys Thr Leu Lys Cys Ile Gin Gin Ile Ile 625 630 635 640 Thr Asp Asn Val Asp Ser Lys Leu Lys Glu Lys Ile Asp Asp Ser Arg 645 650 655 Tyr Val Leu His His Val Ser Asp Phe Gin Gly Leu Pro Thr Tyr Leu 660 665 670 Ala Ser Tyr Val Ile Tyr Gly Arg His Ser Glu Val Thr Asp Ile Gin 675 680 685 Cys Trp Asp Ser Pro Glu Asp Leu Leu Lys Phe Ile Arg Asp Phe Lys 690 695 700 Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin Val Ile Leu Glu Thr 705 710 715 720 Leu Arg Val Val Tyr Asp Ile Trp Lys Ala Glu Lys His Ile Asp Glu 725 730 735 Ile His Val Glu Val Ala Arg Glu Met Lys Leu Thr Ala Gin Gin Arg 740 745 750 Asn Glu Ala Asn Leu Arg Asn Leu Asn Asn Glu Ala Thr Asn Leu Arg 755 760 765 Ile Lys Tyr Leu Leu Glu Glu Leu Lys Asn Asp Thr Phe Ile Lys Asp 770 775 780 Val Arg Pro Leu Ser Pro Ile His Gin Glu Lys Met Arg Ile Tyr Glu 785 790 795 800 Gin Ala Val Leu Gly Asn Leu Asn Lys Gin Asp Lys Asp Tyr Asp Asp 805 810 815 Ile Ile Lys Ile Ser Lys Lys Glu His Pro Thr Asn Ala Glu Leu Ile 820 825 830 Arg Tyr Lys Leu Trp Leu Glu Gin Arg Tyr Cys Ser Pro Tyr Thr Gly 835 840 845 Page 638 of 3790 Ala Asn Ala Asn Ser Pro Lys Gin Arg Glu Asp Leu Arg Gin Leu 131 1138 PRT Bifidobacterium dentium 131 Met Leu Cys Arg Cys His Arg Arg Tyr Arg Ile Gly Ile Asp Val Gly 15 10 15 Leu Met Ser Val Gly Leu Ala Ala Ile Glu Val Asp Glu Thr Gly Phe 20 25 30 Pro Ile Arg Ile Leu Asn Ile Gin Ser Val Ile His Asp Gly Gly Ile 35 40 45 Page 642 of 3790 Lys Arg Lys Leu Thr Ile Ala Glu Lys Gin Arg Val Phe Gly Phe Leu 305 310 315 320 Ser Ser Asn Glu Thr Asp Asp Ile Thr Trp Ile Asp Val Ala Glu Lys 325 330 335 Leu Gly Leu Glu Arg Arg Gin Ile Gin Gly Val Gly Cys Leu Thr Ala 340 345 350 Asp Gly Glu Glu Arg Ile Ser Ser Thr Pro Pro Arg Asn Ile Thr Ala 355 360 365 Leu His Ile His Ser Ala Lys Pro Val Ile Arg Glu Lys Leu Val Ala 370 375 380 Trp Trp Lys Ala Ala Ser Pro Thr Val Arg Glu Thr Met Val Glu Leu 385 390 395 400 Leu Ser Asn Thr Val Asp Ile Asp Arg Val Arg Glu Asp Met Asp Tyr 405 410 415 Ser Ser Ala Val Ala Phe Ile Asp Ser Leu Gly Asp Glu Glu Leu Thr 420 425 430 Ala Leu Asp Ser Val Asp Leu Leu Ser Gly Arg Ala Ala Tyr Ser Arg 435 440 445 Gin Thr Leu Lys Gin Leu Thr Glu Arg Met Leu Asn Thr Asp Asp Asp 450 455 460 Leu His Glu Ala Arg Lys Ala Val Phe Gly Val Asp Asp Asn Trp Lys 465 470 475 480 Pro Pro Val Asp Ala Ile Ser Thr Ser Val Gly Asn Pro Ala Val Asp 485 490 495 Arg Val Leu Lys Ile Val Asn Arg Tyr Leu Leu Ala Cys Gin Lys Arg 500 505 510 Trp Arg Asn Pro Gin Ser Val Gin Ile Glu His Val Arg Glu Ser Phe 515 520 525 Ser Ser Val Ala Lys Ala Lys Glu Thr Glu Arg Val Gin Gly Glu Arg 530 535 540 Ala Arg Tyr Arg Asn Asp Leu Arg Arg Glu Leu Cys Glu Gin Glu Gly 545 550 555 560 Page 643 of 3790 Leu Asn Lys Ile Arg Glu Ser Asp Ile Arg Arg Trp Glu Ser Val Gin 565 570 575 Arg Gin Asn Gly Thr Cys Leu Tyr Cys Gly Ser Pro Ile Thr Phe Arg 580 585 590 Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr 595 600 605 Asn Thr Arg Val Asn Leu Ala Ala Ala Cys Ala Ala Cys Asn Lys Leu 610 615 620 Lys Ser Asn Thr Ala Phe Ser Val Trp Ala Arg Thr Glu Gly Ala Ala 625 630 635 640 Asn Arg Lys Val Ser Gin Arg Asp Ala Ile Glu Arg Val Lys Thr Phe 645 650 655 Ile Phe Asn Lys Ser Val Pro Pro Arg Glu Gin Arg Ala Phe Lys Gin 660 665 670 Ala Val Ile Ser Arg Leu Arg Gin Ala Glu Ser Asp Pro Ala Ile Asp 675 680 685 Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu His Arg 690 695 700 Arg Ile Glu Ala Tyr Phe Asn Gin Asp Ala Asp Val Ser Gly Asn Thr 705 710 715 720 Pro Ala Thr Gin Val Trp Val Phe Gin Gly Arg Val Thr Ala Leu Ala 725 730 735 Arg Lys Ala Ser Gly Ile Glu Gly Arg Ile His Phe Ala Gly Glu Trp 740 745 750 Lys Lys Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val 755 760 765 Ile Ala Met Met Asn His Ser Ala Ala Gin Thr Leu Val Glu Arg Asp 770 775 780 Ser Leu Arg Leu Ser Gin Trp Ile Thr Arg Lys Pro Glu Thr Trp Lys 785 790 795 800 Asn Tyr Pro Phe Ser Glu Gly Gin Lys Lys Thr Arg Phe Lys Glu Trp 805 815 Page 644 of 3790 810 Page 645 of 3790 132 587 PRT Neisseria subflava 132 Met Ala Thr Ser Arg Ser Arg Ile Arg Ser Gin Thr Asp Ala Phe Gly 15 10 15 Val Val Gly Ser Leu Val Ala Phe Asn Gin Thr Ser Arg Leu Phe Val 20 25 30 Ala Lys Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu 35 40 45 Leu Lys 50 Gly Val Ala Asp Asn Ala His Ala Leu 55 Gin Thr Gly Asn Phe 60 Arg Thr Pro Ala Glu 65 Leu Ala 70 Leu Asn Lys Phe Glu Lys 75 Glu Ser Gly 80 His Ile Arg Asn Gin Arg Gly Asp 85 Tyr Ser His 90 Thr Phe Asn Arg Lys 95 Asp Leu Gin Ala Glu Leu Asn Leu Leu Phe Glu Lys Gin Lys 100 105 110 Glu Phe Gly Asn Pro His Val Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu 115 120 125 Page 647 of 3790 Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly 385 390 395 400 Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn 405 410 415 Arg Lys Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro 420 425 430 Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu 435 440 445 Tyr Glu Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn 450 455 460 Leu Gly Arg Leu Asn Glu Lys Gly Tyr Ile Glu Ile Asp His Ala Leu 465 470 475 480 Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val 485 490 495 Leu Gly Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr 500 505 510 Phe Asn Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg 515 520 525 Val Glu Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu 530 535 540 Gin Lys Phe Asp Glu Asp Gly Ile Tyr Arg Ile Gly Val Lys Thr Ala 545 550 555 560 Leu Ser Phe Pro Lys Tyr Gin Ile Asp Glu Leu Gly Lys Glu Ile Arg 565 570 575 Pro Cys Arg Leu Lys Lys Arg Pro Pro Val Arg 580 585 133 1269 PRT Mycoplasma gallisepticum 133 Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 15 10 15 Page 648 of 3790 Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 20 25 30 Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gin Ala Lys Thr Ala 35 40 45 Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 50 55 60 Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 65 70 75 80 Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gin Glu 85 90 95 Gin Gin Lys Leu His Asn Thr Val Leu Asn Leu Lys Ser Glu Ala Leu 100 105 110 Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 115 120 125 Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 130 135 140 Tyr Pro Thr Lys Glu Leu Ala Lys Tyr Phe Asp Lys Tyr Gly Tyr Tyr 145 150 155 160 Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asn Lys Leu Glu Glu 165 170 175 Glu Leu Thr Lys Tyr Lys Phe Ser Asn Lys His Trp Leu Glu Glu Val 180 185 190 Lys Lys Val Leu Ser Asn Gin Thr Gly Leu Pro Glu Lys Phe Lys Glu 195 200 205 Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 210 215 220 Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 225 230 235 240 Lys Glu Gly Lys Val Val Gin Lys Tyr Asn Asn Ile Trp Asp Lys Thr 245 250 255 Ile Gly Lys Cys Asn Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 260 265 270 Page 649 of 3790 Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 275 280 285 Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gin Glu Phe 290 295 300 Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 305 310 315 320 Gly Glu Lys Pro Ile Asp Ala Arg Gin Phe Lys Lys Leu Arg Glu Glu 325 330 335 Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Asn 340 345 350 Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 355 360 365 Lys Leu Asn Thr Asn Gly Lys Ile Gin Tyr Asn Asp Leu Ser Ser Leu 370 375 380 Ala Lys Phe Val His Lys Leu Lys Gin His Leu Lys Leu Asp Phe Leu 385 390 395 400 Leu Glu Asp Gin Tyr Ala Thr Leu Asp Lys Ile Asn Phe Leu Gin Ser 405 410 415 Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 420 425 430 Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 435 440 445 Ile Leu Gin Lys Gin Lys Asp Gly Leu Phe Lys Leu Phe Glu Gin Thr 450 455 460 Asp Lys Asp Asp Glu Lys Ile Leu Ala Gin Thr His Ser Leu Ser Thr 465 470 475 480 Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 485 490 495 Glu Asp Asn Gin Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 500 505 510 Lys Asn Phe Asp Gin Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn Page 650 of 3790 515 520 525 Leu Ser Leu Lys Gin Asn Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 530 535 540 Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 545 550 555 560 Lys Val Phe Asn Ala Ile Leu Lys Gin Phe Ser Glu Glu Tyr Asp Val 565 570 575 Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 580 585 590 Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 595 600 605 Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ser Glu Asp Glu Ile 610 615 620 Lys Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Phe Leu Leu Trp 625 630 635 640 Leu Gin Gin Asp His Ile Asp Pro Tyr Ser Leu Lys Glu Ile Ala Phe 645 650 655 Asp Asp Ile Phe Thr Lys Thr Glu Lys Phe Glu Ile Asp His Ile Ile 660 665 670 Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 675 680 685 Leu Ala Glu Ser Asn Gin Ala Lys Ser Asn Gin Thr Pro Tyr Glu Phe 690 695 700 Ile Ser Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 705 710 715 720 Cys Arg Lys Phe Lys Asp Gly Asp Ser Ser Leu Leu Asp Ser Thr Gin 725 730 735 Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 740 745 750 Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 755 760 765 Page 651 of 3790 Page 652 of 3790 Page 653 of 3790 Leu Asp Lys Ile Val Lys 1265 134 1354 PRT Prevotella melaninogenica 134 Met Ala Asp Phe Ala Lys Tyr Gin 1 5 Pro Gly Met Val Ala Asp Gly Arg 10 15 Lys Ile Pro Leu Asp Trp Thr Leu 20 Tyr Tyr Leu Arg Lys Lys Ala Leu 25 30 Thr Gin Ala Ile Arg Lys Glu Glu 35 40 Leu Ala Trp Ile Leu Leu Asn Phe 45 Asn Gin Lys Arg Gly Tyr Tyr Gin 50 55 Leu Arg Gly Glu Glu Glu Glu Glu 60 Asn Ser Thr Lys His Glu Glu Tyr 65 70 Tyr Glu Leu Lys Val Val Ser Val 75 80 Glu Ala Ala Glu Glu Gly Lys Gly 85 Gly Asn Thr Trp Tyr Asn Val Thr 90 95 Leu Glu Asn Gly Trp Ile Tyr Arg 100 Arg Gin Ser Lys Ile Glu Leu Asn 105 110 Asp Trp Val Gly Lys Val Arg Pro 115 120 Phe Ile Val Thr Thr Glu Tyr Glu 125 Ile Asp Gly Val Thr Ile Lys Lys 130 135 Asp Lys Asn Gly Glu Val Lys Arg 140 Ser Phe Arg Ala Pro Ser Glu Asn 145 150 Asp Trp Gly Leu Arg Lys Lys Arg 155 160 Thr Glu Ser Leu Leu Glu Glu Ser 165 Gly Lys Thr Val Gly Ala Phe Ile 170 175 Tyr Asn His Ile Leu Ser Glu Pro 180 Ala Asp Lys Ile Arg Gly Asn Phe 185 190 Ile Arg Thr Ile Glu Arg Lys Phe 195 200 Tyr Lys Lys Glu Leu Glu Ala Ile 205 Page 654 of 3790 Leu Arg Glu Gin Ser Lys His Gin Lys Glu Leu Lys Asp Ile Asp Thr 210 215 220 Leu Ile Ala Cys Ile Lys Glu Leu Tyr Pro Asn Asn Lys Pro His Gin 225 230 235 240 Asp Ser Leu Ile Lys Lys Asp Met Thr Tyr Leu Leu Ile Thr Asp Leu 245 250 255 Ile Phe Tyr Gin Arg Pro Leu Lys Ser Lys Lys Ser Leu Ile Ala Asp 260 265 270 Cys Pro Tyr Glu Tyr Tyr Glu Tyr Val Ile Lys Glu Thr Gly Glu Asn 275 280 285 Lys Arg Gin Ser Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gin 290 295 300 Glu Phe Arg Leu Trp Gin Phe Ile Ile Asn Leu Arg Leu Phe Asp Arg 305 310 315 320 Asn Asn Asp Lys Glu Val Thr Ser Glu Tyr Leu Ser Ser Met Glu Asp 325 330 335 Tyr Thr Arg Leu Phe Thr Tyr Leu Asn Asp Arg Lys Asp Ile Asn Gin 340 345 350 Glu Thr Leu Leu Lys Asp Phe Phe Lys Gin Lys Lys Val Lys Arg Gly 355 360 365 Met Glu Lys Glu Phe Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu 370 375 380 Lys Lys Tyr Pro Cys Asn Glu Thr Arg His Glu Leu Leu Thr Ala Leu 385 390 395 400 Gly Lys Val Gly Ile Asp His Ser Trp Leu Asp Asp Lys Glu Leu Phe 405 410 415 Tyr Arg Leu Trp His Leu Leu Tyr Ser Val Glu Ser Lys Glu Glu Ala 420 425 430 Glu Gly Ala Leu Arg Lys Leu Val Asp Asn Asp Asp Phe Val Asn Ala 435 440 445 Phe Leu Lys Ile Lys Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Glu Page 657 of 3790 Lys Pro Trp Glu Thr Phe Thr Gin Asp Ala His Thr Ala Leu Glu Asn 965 970 975 Val Val Val Ser Phe Lys Asn Tyr Ile Arg Val Ile Asn Lys Ala Thr 980 985 990 Asn Tyr Tyr Glu Lys Tyr Asp Lys Asn Gly Lys Lys Glu Ile Ala Glu 995 1000 1005 Gin Lys Gly Gin Asp Met Trp Ala Ile Arg Lys Pro Met His Lys 1010 1015 1020 Glu Thr Val Phe Gly Gin Val Asn Leu Arg Arg Lys Ile Thr Ile 1025 1030 1035 Lys Leu Lys Asp Ala Leu Glu Lys Ile Pro Ala Ile Cys Asp Lys 1040 1045 1050 Glu Leu Arg Asp Tyr Ile Asn Ile Leu Val Ala Lys Gin Phe Asn 1055 1060 1065 Lys Lys Gin Ile Leu Ala His Phe Lys Ser Ile Asn Tyr Arg Leu 1070 1075 1080 Asn Met Lys Ser Val Asp Lys Val Asp Val Trp Gin Phe Ser Asn 1085 1090 1095 Glu Lys Glu Pro Met Val Ala Thr Arg Lys Ser Val Asp Thr Ser 1100 1105 1110 Phe Asp Thr Lys Arg Ile Ala Thr Ile Thr Asp Thr Gly Ile Gin 1115 1120 1125 Lys Ile Leu Leu Asn Tyr Leu Lys Ala Lys Asn Asn Asp Pro Asn 1130 1135 1140 Ile Ala Phe Thr Pro Glu Gly Ile Ala Glu Met Asn Lys His Ile 1145 1150 1155 Thr Glu Tyr Asn Asn Gly Lys Gin His Gin Pro Ile Leu Lys Val 1160 1165 1170 Arg Val Ser Glu Pro Lys Gly Ala Lys Tyr Gin Val Gly Glu Thr 1175 1180 1185 Gly Asn Lys Arg Ser Lys Phe Val Glu Ala Gin Lys Gly Thr Asn 1190 1195 1200 Page 658 of 3790 Lys 135 1130 PRT Streptococcus gallolyticus 135 Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 15 10 15 Gly Val Gly Ile Ile Glu Ala Lys Thr Gly Lys Val Val His Ala Asn 20 25 30 Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 35 40 45 Page 659 of 3790 Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 50 55 60 Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Glu Ile Val Thr Asp Phe 65 70 75 80 Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 85 90 95 Glu Gin Leu Thr Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 100 105 110 Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 115 120 125 Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 130 135 140 Lys Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Leu Glu Lys Tyr 145 150 155 160 Gly Gin Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 165 170 175 His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 180 185 190 Arg Lys Ile Leu Glu Thr Gin Ala Asp Tyr Asn Lys Lys Ile Thr Ala 195 200 205 Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gin Lys Arg Lys Tyr 210 215 220 Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 225 230 235 240 Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 245 250 255 Lys Cys Ser Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 260 265 270 Thr Ala Gin Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 275 280 285 Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gin Lys Glu Ala Leu Val Page 662 of 3790 Page 663 of 3790 Lys Lys 1130 136 1371 PRT Streptococcus gallolyticus 136 Page 664 of 3790 Tyr His Gin Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 130 135 140 Asp Ser His Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 145 150 155 160 His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn 165 170 175 Ala Glu Asn Thr Asp Val Gin Lys Leu Phe Glu Ala Phe Val Glu Val 180 185 190 Tyr Asp Arg Thr Phe Asp Asp Ser Asn Leu Ser Glu Ile Thr Val Asp 195 200 205 Ala Ser Ser Ile Leu Thr Glu Lys Phe Ser Lys Ser Arg Arg Leu Glu 210 215 220 Asn Leu Ile Lys His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 225 230 235 240 Asn Leu Val Ala Leu Ala Leu Gly Leu Gin Pro Asn Phe Lys Thr Ser 245 250 255 Phe Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr 260 265 270 Glu Glu Asp Leu Glu Glu Leu Ile Gly Lys Ile Gly Asp Glu Tyr Ala 275 280 285 Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Ala Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Lys Arg Tyr Asn Glu His Gin Val Asp Leu Lys Lys Leu 325 330 335 Lys Glu Phe Ile Lys Asn Asn Ala Ser Asp Lys Tyr Asp Glu Ile Phe 340 345 350 Asn Asp Lys Asp Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 355 360 365 Lys Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Thr Leu Ser Lys Ile Page 667 of 3790 Page 668 of 3790 Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Lys Leu Page 669 of 3790 1355 1360 1365 Gly Glu Glu 1370 Pro Arg Arg Glu His Val Asn Gly 10 15 Trp Thr Pro Asp Pro His Arg Ile 20 Ser Lys Pro Phe Phe Ile Leu Val 25 30 Ser Trp His Leu Leu Ser Arg Val 35 40 Val Ile Asp Ser Ser Ser Gly Cys 45 Phe Pro Gly Thr Ser Arg Asp His 50 55 Thr Asp Lys Phe Ala Glu Trp Glu 60 Cys Ala Val Gin Pro Tyr Arg Leu 65 70 Ser Phe Asp Leu Gly Thr Asn Ser 75 80 Ile Gly Trp Gly Leu Leu Asn Leu 85 Asp Arg Gin Gly Lys Pro Arg Glu 90 95 Ile Arg Ala Leu Gly Ser Arg Ile 100 Phe Ser Asp Gly Arg Asp Pro Gin 105 110 Asp Lys Ala Ser Leu Ala Val Ala 115 120 Arg Arg Leu Ala Arg Gin Met Arg 125 Arg Arg Arg Asp Arg Tyr Leu Thr 130 135 Arg Arg Thr Arg Leu Met Gly Ala 140 Leu Val Arg Phe Gly Leu Met Pro 145 150 Ala Asp Pro Ala Ala Arg Lys Arg 155 160 Leu Glu Val Ala Val Asp Pro Tyr 165 Leu Ala Arg Glu Arg Ala Thr Arg 170 175 Glu Arg Leu Glu Pro Phe Glu Ile 180 Gly Arg Ala Leu Phe His Leu Asn 185 190 Gin Arg Arg Gly Tyr Lys Pro Val Arg Thr Ala Thr Lys Pro Asp Glu Page 670 of 3790 195 200 205 Glu Ala Gly Lys Val Lys Glu Ala Val Glu Arg Leu Glu Ala Ala Ile 210 215 220 Ala Ala Ala Gly Ala Pro Thr Leu Gly Ala Trp Phe Ala Trp Arg Lys 225 230 235 240 Thr Arg Gly Glu Thr Leu Arg Ala Arg Leu Ala Gly Lys Gly Lys Glu 245 250 255 Ala Ala Tyr Pro Phe Tyr Pro Ala Arg Arg Met Leu Glu Ala Glu Phe 260 265 270 Asp Thr Leu Trp Ala Glu Gin Ala Arg His His Pro Asp Leu Leu Thr 275 280 285 Ala Glu Ala Arg Glu Ile Leu Arg His Arg Ile Phe His Gin Arg Pro 290 295 300 Leu Lys Pro Pro Pro Val Gly Arg Cys Thr Leu Tyr Pro Asp Asp Gly 305 310 315 320 Arg Ala Pro Arg Ala Leu Pro Ser Ala Gin Arg Leu Arg Leu Phe Gin 325 330 335 Glu Leu Ala Ser Leu Arg Val Ile His Leu Asp Leu Ser Glu Arg Pro 340 345 350 Leu Thr Pro Ala Glu Arg Asp Arg Ile Val Ala Phe Val Gin Gly Arg 355 360 365 Pro Pro Lys Ala Gly Arg Lys Pro Gly Lys Val Gin Lys Ser Val Pro 370 375 380 Phe Glu Lys Leu Arg Gly Leu Leu Glu Leu Pro Pro Gly Thr Gly Phe 385 390 395 400 Ser Leu Glu Ser Asp Lys Arg Pro Glu Leu Leu Gly Asp Glu Thr Gly 405 410 415 Ala Arg Ile Ala Pro Ala Phe Gly Pro Gly Trp Thr Ala Leu Pro Leu 420 425 430 Glu Glu Gin Asp Ala Leu Val Glu Leu Leu Leu Thr Glu Ala Glu Pro 435 440 445 Page 671 of 3790 Glu Arg Ala Ile Ala Ala Leu Thr Ala Arg Trp Ala Leu Asp Glu Ala 450 455 460 Thr Ala Ala Lys Leu Ala Gly Ala Thr Leu Pro Asp Phe His Gly Arg 465 470 475 480 Tyr Gly Arg Arg Ala Val Ala Glu Leu Leu Pro Val Leu Glu Arg Glu 485 490 495 Thr Arg Gly Asp Pro Asp Gly Arg Val Arg Pro Ile Arg Leu Asp Glu 500 505 510 Ala Val Lys Leu Leu Arg Gly Gly Lys Asp His Ser Asp Phe Ser Arg 515 520 525 Glu Gly Ala Leu Leu Asp Ala Leu Pro Tyr Tyr Gly Ala Val Leu Glu 530 535 540 Arg His Val Ala Phe Gly Thr Gly Asn Pro Ala Asp Pro Glu Glu Lys 545 550 555 560 Arg Val Gly Arg Val Ala Asn Pro Thr Val His Ile Ala Leu Asn Gin 565 570 575 Leu Arg His Leu Val Asn Ala Ile Leu Ala Arg His Gly Arg Pro Glu 580 585 590 Glu Ile Val Ile Glu Leu Ala Arg Asp Leu Lys Arg Ser Ala Glu Asp 595 600 605 Arg Arg Arg Glu Asp Lys Arg Gin Ala Asp Asn Gin Lys Arg Asn Glu 610 615 620 Glu Arg Lys Arg Leu Ile Leu Ser Leu Gly Glu Arg Pro Thr Pro Arg 625 630 635 640 Asn Leu Leu Lys Leu Arg Leu Trp Glu Glu Gin Gly Pro Val Glu Asn 645 650 655 Arg Arg Cys Pro Tyr Ser Gly Glu Thr Ile Ser Met Arg Met Leu Leu 660 665 670 Ser Glu Gin Val Asp 675 Ile Asp His 680 Ile Leu Pro Phe Ser Val 685 Ser Leu Asp Asp Ser Ala Ala Asn Lys Val Val Cys Leu Arg Glu Ala Asn Arg 690 695 700 Page 672 of 3790 Ile Lys Arg Asn Arg Ser Pro Trp Glu Ala Phe Gly His Asp Ser Glu 705 710 715 720 Arg Trp Ala Gly Ile Leu Ala Arg Ala Glu Ala Leu Pro Lys Asn Lys 725 730 735 Arg Trp Arg Phe Ala Pro Asp Ala Leu Glu Lys Leu Glu Gly Glu Gly 740 745 750 Gly Leu Arg Ala Arg His Leu Asn Asp Thr Arg His Leu Ser Arg Leu 755 760 765 Ala Val Glu Tyr Leu Arg Cys Val Cys Pro Lys Val Arg Val Ser Pro 770 775 780 Gly Arg Leu Thr Ala Leu Leu Arg Arg Arg Trp Gly Ile Asp Ala Ile 785 790 795 800 Leu Ala Glu Ala Asp Gly Pro Pro Pro Glu Val Pro Ala Glu Thr Leu 805 810 815 Asp Pro Ser Pro Ala Glu Lys Asn Arg Ala Asp His Arg His His Ala 820 825 830 Leu Asp Ala Val Val Ile Gly Cys Ile Asp Arg Ser Met Val Gin Arg 835 840 845 Val Gin Leu Ala Ala Ala Ser Ala Glu Arg Glu Ala Ala Ala Arg Glu 850 855 860 Asp Asn Ile Arg Arg Val Leu Glu Gly Phe Lys Glu Glu Pro Trp Asp 865 870 875 880 Gly Phe Arg Ala Glu Leu Glu Arg Arg Ala Arg Thr Ile Val Val Ser 885 890 895 His Arg Pro Glu His Gly Ile Gly Gly Ala Leu His Lys Glu Thr Ala 900 905 910 Tyr Gly Pro Val Asp Pro Pro Glu Glu Gly Phe Asn Leu Val Val Arg 915 920 925 Lys Pro 930 Ile Asp Gly Leu Ser Lys Asp Glu 935 Ile Asn 940 Ser Val Arg Asp Pro Arg Leu Arg Arg Ala Leu Ile Asp Arg Leu Ala Ile Arg Arg Arg 945 950 955 960 Page 673 of 3790 Asp Ala Asn Asp Pro Ala Thr Ala 965 Ala Ala Gin Pro Ala Ser Arg Gly 980 Lys Glu Ser Asn Pro Ile Arg Val 995 1000 Leu Ala Lys Ala Ala Glu Asp Leu 970 975 Ile Arg Arg Val Arg Val Leu Lys 985 990 Ile Ser Glu His Gly Gly Asn Pro Ser Gly Page 674 of 3790 138 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe Page 676 of 3790 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Page 677 of 3790 Page 678 of 3790 Asp Tyr Val Asp Lys His Lys Asp Glu Phe Lys Glu Leu Leu Asp 1340 1345 139 1024 PRT Helicobacter mustelae 139 Lys Leu Ala Thr Leu Phe Gin Thr Ser Lys Asp Phe Leu Ser Pro Trp 580 585 590 Ala Leu Gin Ile Asp His Ala Phe Pro Leu Ser Arg Ser Leu Asp Asp 595 600 605 Page 682 of 3790 Ser Gin Ser Asn Lys Val Leu Cys Leu Thr Ser Ser Asn Gin Glu Lys 610 615 620 Ser Asn Lys Thr Pro Tyr Glu Trp Leu Gly Ser Asp Glu Lys Lys Trp 625 630 635 640 Asp Met Tyr Val Gly Arg Val Tyr Ser Ser Asn Phe Ser Pro Ser Lys 645 650 655 Lys Arg Lys Leu Thr Gin Lys Asn Phe Lys Glu Arg Asn Glu Glu Asp 660 665 670 Phe Leu Ala Arg Asn Leu Val Asp Thr Gly Tyr Ile Gly Arg Val Thr 675 680 685 Lys Glu Tyr Ile Lys His Ser Leu Ser Phe Leu Pro Leu Pro Asp Gly 690 695 700 Lys Lys Glu His Ile Arg Ile Ile Ser Gly Ser Met Thr Ser Thr Met 705 710 715 720 Arg Ser Phe Trp Gly Val Gin Glu Lys Asn Arg Asp His His Leu His 725 730 735 His Ala Gin Asp Ala Ile Ile Ile Ala Cys Ile Glu Pro Ser Met Ile 740 745 750 Gin Lys Tyr Thr Thr Tyr Leu Lys Asp Lys Glu Thr His Arg Leu Lys 755 760 765 Ser His Gin Lys Ala Gin Ile Leu Arg Glu Gly Asp His Lys Leu Ser 770 775 780 Leu Arg Trp Pro Met Ser Asn Phe Lys Asp Lys Ile Gin Glu Ser Ile 785 790 795 800 Gin Asn Ile Ile Pro Ser His His Val Ser His Lys Val Thr Gly Glu 805 810 815 Leu His Gin Glu Thr Val Arg Thr Lys Glu Phe Tyr Tyr Gin Ala Phe 820 825 830 Gly Gly Glu Glu Gly Val Lys Lys Ala Leu Lys Phe Gly Lys Ile Arg 835 840 845 Glu Ile Asn Gin Gly Ile Val Asp Asn Gly Ala Met Val Arg Val Asp 850 855 860 Page 683 of 3790 Pro Arg Asn Arg Gin Asn Ile Ala Leu Lys Thr Thr Pro Lys His 1010 1015 1020 Val 140 765 PRT Butyrivibrio fibrisolvens 140 Met Gly Ile Thr Ile Gly Leu Asp Leu Gly Val Ala Ser Val Gly Trp 15 10 15 Ala Val Val Asn Asp Asp Tyr Glu Ile Leu Glu Ser Cys Ser Asn Ile 20 25 30 Phe Pro Ser Ala Asp Ala Ser Lys Asn Ser Glu Arg Arg Gly Phe Arg 35 40 45 Page 684 of 3790 Gin Gly Arg Arg Leu Thr Arg Arg Arg Lys Asn Arg Ile His Asp Phe 50 55 60 Gin Lys Leu Trp Glu Asp Lys Gly Phe Val Ile Pro Ser Gin Gly Thr 65 70 75 80 Glu Asp Val Leu Ala Ile Lys Ile Lys Gly Leu Ser Glu Lys Leu Ser 85 90 95 Val Asp Glu Val Tyr Trp Val Leu Leu Asn Ser Leu Lys His Arg Gly 100 105 110 Ile Ser Tyr Leu Asp Asp Ala Asp Ser Gly Asp Asn Ser Ser Asp Tyr 115 120 125 Ala Lys Ser Ile Ser Arg Asn Glu Glu Glu Leu Lys Glu Lys Leu Pro 130 135 140 Cys Glu Ile Gin Trp Glu Arg Leu Gin Lys Tyr Gly Ala Tyr Arg Gly 145 150 155 160 Asn Ile Ser Ile Val Glu Asp Gly Glu Pro Ile Thr Leu Arg Asn Val 165 170 175 Phe Thr Thr Ser Ala Tyr Lys Lys Glu Val Glu Gin Phe Ile Asp Thr 180 185 190 Gin Ala Lys Tyr Asn Ala Gin Tyr Ser Gly Asp Phe Lys Ala Asp Tyr 195 200 205 Leu Glu Ile Phe Asn Arg Lys Arg Glu Tyr Tyr Glu Gly Pro Gly Asn 210 215 220 Glu Leu Ser Arg Thr Asp Tyr Gly Lys Tyr Thr Thr Glu Ile Asn Ala 225 230 235 240 Asp Gly Glu Tyr Ile Thr Val Asp Asn Ile Phe Asp Lys Leu Val Gly 245 250 255 Lys Cys Ser Val Asn Pro Asp Glu Arg Arg Ala Ala Gly Ala Ser Tyr 260 265 270 Thr Ala Gin Glu Phe Asn Val Leu Asn Asp Leu Asn Asn Leu Thr Ile 275 280 285 Ser Ser Glu Ser Ser Phe Ile Glu Asp Gly Lys Leu Thr Glu Asp Ala Page 687 of 3790 Met Lys Gin Glu Tyr Phe Leu Gly Leu Asp Met Gly Thr Gly Ser Leu 15 10 15 Gly Trp Ala Val Thr Asp Ser Thr Tyr Gin Val Met Arg Lys His Gly 20 25 30 Lys Ala Leu Trp Gly Thr Arg Leu Phe Glu Ser Ala Ser Thr Ala Glu 35 40 45 Glu Arg Arg Met Phe Arg Thr Ala Arg Arg Arg Leu Asp Arg Arg Asn 50 55 60 Trp Arg Ile Gin Val Leu Gin Glu Ile Phe Ser Glu Glu Ile Ser Lys 65 70 75 80 Val Asp Pro Gly Phe Phe Leu Arg Met Lys Glu Ser Lys Tyr Tyr Pro 85 90 95 Glu Asp Lys Arg Asp Ala Glu Gly Asn Cys Pro Glu Leu Pro Tyr Ala 100 105 110 Leu Phe Val Asp Asp Asn Tyr Thr Asp Lys Asn Tyr His Lys Asp Tyr 115 120 125 Pro Thr Ile Tyr His Leu Arg Lys Met Leu Met Glu Thr Thr Glu Ile 130 135 140 Pro Asp Ile Arg Leu Val Tyr Leu Val Leu His His Met Met Lys His 145 150 155 160 Arg Gly His Phe Leu Leu Ser Gly Asp Ile Ser Gin Ile Lys Glu Phe 165 170 175 Lys Ser Thr Phe Glu Gin Leu Ile Gin Asn Ile Gin Asp Glu Glu Leu 180 185 190 Glu Trp His Ile Ser Leu Asp Asp Ala Ala Ile Gin Phe Val Glu His 195 200 205 Val Leu Lys Asp Arg Asn Leu Thr Arg Ser Thr Lys Lys Ser Arg Leu 210 215 220 Ile Lys Gin Leu Asn Ala Lys Ser Ala Cys Glu Lys Ala Ile Leu Asn 225 230 235 240 Leu Leu Ser Gly Gly Thr Val Lys Leu Ser Asp Ile Phe Asn Asn Lys 245 250 255 Page 688 of 3790 Glu Leu Asp Glu Ser Glu Arg Pro Lys Val Ser Phe Ala Asp Ser Gly 260 265 270 Tyr Asp Asp Tyr Ile Gly Ile Val Glu Ala Glu Leu Ala Glu Gin Tyr 275 280 285 Tyr Ile Ile Ala Ser Ala Lys Ala Val Tyr Asp Trp Ser Val Leu Val 290 295 300 Glu Ile Leu Gly Asn Ser Val Ser Ile Ser Glu Ala Lys Ile Lys Val 305 310 315 320 Tyr Gin Lys His Gin Ala Asp Leu Lys Thr Leu Lys Lys Ile Val Arg 325 330 335 Gin Tyr Met Thr Lys Glu Asp Tyr Lys Arg Val Phe Val Asp Thr Glu 340 345 350 Glu Lys Leu Asn Asn Tyr Ser Ala Tyr Ile Gly Met Thr Lys Lys Asn 355 360 365 Gly Lys Lys Val Asp Leu Lys Ser Lys Gin Cys Thr Gin Ala Asp Phe 370 375 380 Tyr Asp Phe Leu Lys Lys Asn Val Ile Lys Val Ile Asp His Lys Glu 385 390 395 400 Ile Thr Gin Glu Ile Glu Ser Glu Ile Glu Lys Glu Asn Phe Leu Pro 405 410 415 Lys Gin Val Thr Lys Asp Asn Gly Val Ile Pro Tyr Gin Val His Asp 420 425 430 Tyr Glu Leu Lys Lys Ile Leu Asp Asn Leu Gly Thr Arg Met Pro Phe 435 440 445 Ile Lys Glu Asn Ala Glu Lys Ile Gin Gin Leu Phe Glu Phe Arg Ile 450 455 460 Pro Tyr Tyr Val Gly Pro Leu Asn Arg Val Asp Asp Gly Lys Asp Gly 465 470 475 480 Lys Phe Thr Trp Ser Val Arg Lys Ser Asp Ala Arg Ile Tyr Pro Trp 485 490 495 Asn Phe Thr Glu Val Ile Asp Val Glu Ala Ser Ala Glu Lys Phe Ile 500 505 510 Page 689 of 3790 Arg Arg Met Thr Asn Lys Cys Thr Tyr Leu Val Gly Glu Asp Val Leu 515 520 525 Pro Lys Asp Ser Leu Val Tyr Ser Lys Phe Met Val Leu Asn Glu Leu 530 535 540 Asn Asn Leu Arg Leu Asn Gly Glu Lys Ile Ser Val Glu Leu Lys Gin 545 550 555 560 Arg Ile Tyr Glu Glu Leu Phe Cys Lys Tyr Arg Lys Val Thr Arg Lys 565 570 575 Lys Leu Glu Arg Tyr Leu Val Ile Glu Gly Ile Ala Lys Lys Gly Val 580 585 590 Glu Ile Thr Gly Ile Asp Gly Asp Phe Lys Ala Ser Leu Thr Ala Tyr 595 600 605 His Asp Phe Lys Glu Arg Leu Thr Asp Val Gin Leu Ser Gin Arg Ala 610 615 620 Lys Glu Ala Ile Val Leu Asn Val Val Leu Phe Gly Asp Asp Lys Lys 625 630 635 640 Leu Leu Lys Gin Arg Leu Ser Lys Met Tyr Pro Asn Leu Thr Thr Gly 645 650 655 Gin Leu Lys Gly Ile Cys Ser Leu Ser Tyr Gin Gly Trp Gly Arg Leu 660 665 670 Ser Lys Thr Phe Leu Glu Glu Ile Thr Val Pro Ala Pro Gly Thr Gly 675 680 685 Glu Val Trp Asn Ile Met Thr Ala Leu Trp Gin Thr Asn Asp Asn Leu 690 695 700 Met Gin Leu Leu Ser Arg Asn Tyr Gly Phe Thr Asn Glu Val Glu Glu 705 710 715 720 Phe Asn Thr Leu Lys Lys Glu Thr Asp Leu Ser Tyr Lys Thr Val Asp 725 730 735 Glu Leu Tyr Val Ser Pro Ala Val Lys Arg Gin Ile Trp Gin Thr Leu 740 745 750 Lys Val Val Lys Glu Ile Gin Lys Val Met Gly Asn Ala Pro Lys Arg Page 690 of 3790 Page 691 of 3790 Page 692 of 3790 142 1035 PRT Candidatus Puniceispirillum 142 Met Arg Arg Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp Cys 15 10 15 Leu Leu Asp Leu Gly Asp Asp Gly Glu Pro Val Ser Ile Phe Arg Thr 20 25 30 Gly Ala Arg Ile Phe Ser Asp Gly Arg Asp Pro Lys Ser Leu Gly Ser 35 40 45 Leu Lys Ala Thr Arg Arg Glu Ala Arg Leu Thr Arg Arg Arg Arg Asp 50 55 60 Arg Phe Ile Gin Arg Gin Lys Asn Leu Ile Asn Ala Leu Val Lys Tyr 65 70 75 80 Gly Leu Met Pro Ala Asp Glu Ile Gin Arg Gin Ala Leu Ala Tyr Lys 85 90 95 Asp Pro Tyr Pro Ile Arg Lys Lys Ala Leu Asp Glu Ala Ile Asp Pro 100 105 110 Tyr Glu Met Gly Arg Ala Ile Phe His Ile Asn Gin Arg Arg Gly Phe 115 120 125 Page 693 of 3790 Lys Ser Asn Arg Lys Ser Ala Asp Asn Glu Ala Gly Val Val Lys Gin 130 135 140 Ser Ile Ala Asp Leu Glu Met Lys Leu Gly Glu Ala Gly Ala Arg Thr 145 150 155 160 Ile Gly Glu Phe Leu Ala Asp Arg Gin Ala Thr Asn Asp Thr Val Arg 165 170 175 Ala Arg Arg Leu Ser Gly Thr Asn Ala Leu Tyr Glu Phe Tyr Pro Asp 180 185 190 Arg Tyr Met Leu Glu Gin Glu Phe Asp Thr Leu Trp Ala Lys Gin Ala 195 200 205 Ala Phe Asn Pro Ser Leu Tyr Ile Glu Ala Ala Arg Glu Arg Leu Lys 210 215 220 Glu Ile Val Phe Phe Gin Arg Lys Leu Lys Pro Gin Glu Val Gly Arg 225 230 235 240 Cys Ile Phe Leu Ser Asp Glu Asp Arg Ile Ser Lys Ala Leu Pro Ser 245 250 255 Phe Gin Arg Phe Arg Ile Tyr Gin Glu Leu Ser Asn Leu Ala Trp Ile 260 265 270 Asp His Asp Gly Val Ala His Arg Ile Thr Ala Ser Leu Ala Leu Arg 275 280 285 Asp His Leu Phe Asp Glu Leu Glu His Lys Lys Lys Leu Thr Phe Lys 290 295 300 Ala Met Arg Ala Ile Leu Arg Lys Gin Gly Val Val Asp Tyr Pro Val 305 310 315 320 Gly Phe Asn Leu Glu Ser Asp Asn Arg Asp His Leu Ile Gly Asn Leu 325 330 335 Thr Ser Cys Ile Met Arg Asp Ala Lys Lys Met Ile Gly Ser Ala Trp 340 345 350 Asp Arg Leu Asp Glu Glu Glu Gin Asp Ser Phe Ile Leu Met Leu Gin 355 360 365 Asp Asp Gin Lys Gly Asp Asp Glu Val Arg Ser Ile Leu Thr Gin Gin 370 375 380 Page 694 of 3790 Tyr Gly Leu Ser Asp Asp Val Ala Glu Asp Cys Leu Asp Val Arg Leu 385 390 395 400 Pro Asp Gly His Gly Ser Leu Ser Lys Lys Ala Ile Asp Arg Ile Leu 405 410 415 Pro Val Leu Arg Asp Gin Gly Leu Ile Tyr Tyr Asp Ala Val Lys Glu 420 425 430 Ala Gly Leu Gly Glu Ala Asn Leu Tyr Asp Pro Tyr Ala Ala Leu Ser 435 440 445 Asp Lys Leu Asp Tyr Tyr Gly Lys Ala Leu Ala Gly His Val Met Gly 450 455 460 Ala Ser Gly Lys Phe Glu Asp Ser Asp Glu Lys Arg Tyr Gly Thr Ile 465 470 475 480 Ser Asn Pro Thr Val His Ile Ala Leu Asn Gin Val Arg Ala Val Val 485 490 495 Asn Glu Leu Ile Arg Leu His Gly Lys Pro Asp Glu Val Val Ile Glu 500 505 510 Ile Gly Arg Asp Leu Pro Met Gly Ala Asp Gly Lys Arg Glu Leu Glu 515 520 525 Arg Phe Gin Lys Glu Gly Arg Ala Lys Asn Glu Arg Ala Arg Asp Glu 530 535 540 Leu Lys Lys Leu Gly His Ile Asp Ser Arg Glu Ser Arg Gin Lys Phe 545 550 555 560 Gin Leu Trp Glu Gin Leu Ala Lys Glu Pro Val Asp Arg Cys Cys Pro 565 570 575 Phe Thr Gly Lys Met Met Ser Ile Ser Asp Leu Phe Ser Asp Lys Val 580 585 590 Glu Ile Glu His Leu Leu Pro Phe Ser Leu Thr Leu Asp Asp Ser Met 595 600 605 Ala Asn Lys Thr Val Cys Phe Arg Gin Ala Asn Arg Asp Lys Gly Asn 610 615 620 Arg Ala Pro Phe Asp Ala Phe Gly Asn Ser Pro Ala Gly Tyr Asp Trp Page 696 of 3790 Thr Ser Lys Ser Pro Gly Lys Leu Gin Ser Ala Ser Ala Arg Lys 1010 1015 1020 Val His Ile Ser Pro Thr Gly Leu Ile Arg Glu Gly 1025 1030 1035 143 1270 PRT Mycoplasma gallisepticum 143 Met Asn Asn Ser Ile Lys Ser Lys Pro Glu Val Thr Ile Gly Leu Asp 15 10 15 Leu Gly Val Gly Ser Val Gly Trp Ala Ile Val Asp Asn Glu Thr Asn 20 25 30 Ile Ile His His Leu Gly Ser Arg Leu Phe Ser Gin Ala Lys Thr Ala 35 40 45 Glu Asp Arg Arg Ser Phe Arg Gly Val Arg Arg Leu Ile Arg Arg Arg 50 55 60 Page 697 of 3790 Lys Tyr Lys Leu Lys Arg Phe Val Asn Leu Ile Trp Lys Tyr Asn Ser 65 70 75 80 Tyr Phe Gly Phe Lys Asn Lys Glu Asp Ile Leu Asn Asn Tyr Gin Glu 85 90 95 Gin Gin Lys Leu His Asn Thr Val Leu Asn Leu Lys Leu Glu Ala Leu 100 105 110 Asn Ala Lys Ile Asp Pro Lys Ala Leu Ser Trp Ile Leu His Asp Tyr 115 120 125 Leu Lys Asn Arg Gly His Phe Tyr Glu Asp Asn Arg Asp Phe Asn Val 130 135 140 Tyr Pro Thr Glu Glu Leu Ala Asn Tyr Phe Asp Glu Phe Gly Tyr Tyr 145 150 155 160 Lys Gly Ile Ile Asp Ser Lys Asn Asp Asp Asp Asp Lys Leu Glu Glu 165 170 175 Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gin His Trp Leu Glu Glu Val 180 185 190 Lys Lys Val Leu Ser Asn Gin Thr Gly Leu Pro Glu Lys Phe Lys Glu 195 200 205 Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 210 215 220 Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 225 230 235 240 Lys Glu Gly Lys Val Val Gin Lys Tyr Asn Asn Ile Trp Asp Lys Thr 245 250 255 Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 260 265 270 Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 275 280 285 Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gin Glu Phe 290 295 300 Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 305 310 315 320 Page 698 of 3790 Ser Glu Lys Pro Ile Asp Ala Arg Gin Phe Lys Lys Leu Arg Glu Glu 325 330 335 Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Ser 340 345 350 Glu Glu Lys Leu Glu Lys Asp Asp His Lys Trp Lys Leu Lys Gly Leu 355 360 365 Lys Leu Asn Thr Asn Gly Lys Ile Gin Tyr Asn Asp Leu Ser Ser Leu 370 375 380 Ala Lys Phe Val His Lys Leu Lys Gin His Leu Lys Leu Asp Phe Leu 385 390 395 400 Leu Glu Asp Gin Tyr Thr Pro Leu Asp Lys Ile Asn Phe Leu Gin Ser 405 410 415 Leu Tyr Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 420 425 430 Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Ser Arg Leu Phe Glu Arg 435 440 445 Val Leu Gin Glu Gin Lys Asp Gly Leu Phe Lys Leu Phe Glu Gin Thr 450 455 460 Asp Lys Asp Asp Glu Lys Ile Leu Thr Gin Thr His Ser Leu Ser Thr 465 470 475 480 Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 485 490 495 Glu Asp Asn Gin Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 500 505 510 Lys Asn Phe Asp Gin Lys Phe Ile Asp Ile Thr Lys Thr Asn Asn Asn 515 520 525 Leu Ser Leu Lys Gin Asp Lys Arg Tyr Leu Asp Asp Gin Phe Ile Asn 530 535 540 Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 545 550 555 560 Lys Val Phe Asn Ala Ile Leu Lys Gin Phe Ser Glu Glu Tyr Asp Val 565 570 575 Page 699 of 3790 Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 580 585 590 Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 595 600 605 Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ala Glu Asp Lys Ile 610 615 620 Glu Glu Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 625 630 635 640 Leu Gin Gin Asp His Ile Asp Pro Tyr Ser Gin Lys Glu Ile Ala Phe 645 650 655 Asp Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 660 665 670 Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 675 680 685 Leu Ala Glu Ser Asn Gin Ala Lys Ser Asn Gin Thr Pro Tyr Glu Phe 690 695 700 Ile Asn Ser Gly Lys Ala Glu Ile Thr Trp Glu Val Tyr Glu Ala Tyr 705 710 715 720 Cys His Lys Phe Lys Asn Gly Asp Ser Ser Leu Leu Asp Ser Thr Gin 725 730 735 Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 740 745 750 Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 755 760 765 Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala Asn Asn His Leu 770 775 780 Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Gly Val 785 790 795 800 Thr Ser Phe Leu Arg Lys Asn Phe Asp Pro Lys Ser Trp Tyr Ala Lys 805 810 815 Lys Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile 820 830 Page 700 of 3790 825 Page 701 of 3790 1265 1270 144 1204 PRT Prevotella ruminicola 144 Page 702 of 3790 Met Glu Arg Ile Leu Gly Ile Asp Thr Gly Thr Asn Ser Leu Gly Trp 15 10 15 Ala Ile Val Asp Lys Asp Glu Asn Gin Tyr His Leu Val Ala Lys Gly 20 25 30 Thr Asn Ile Phe Ser Glu Gly Val Lys Ile Glu Lys Gly Ile Glu Ser 35 40 45 Ser Lys Ala Ala Glu Arg Thr Glu His Arg Ser Val Arg Lys His Tyr 50 55 60 Trp Arg Arg Lys Ile Arg Lys Ile Arg Leu Leu Thr Ile Leu Ser Asp 65 70 75 80 Asn Asp Leu Cys Pro Arg Leu Lys His Glu Gin Leu Arg Gin Trp Arg 85 90 95 Leu Lys Lys Val Tyr Pro Thr Asp Asp Thr Phe Met Glu Trp Gin Arg 100 105 110 Thr Glu Asp Lys Ala Gin Val Asn Pro Tyr Lys Phe Arg Tyr Ile Cys 115 120 125 Leu Thr Gin Lys Leu Asp Leu Ser Asp Ile Thr Gin Arg Phe Ile Leu 130 135 140 Gly Arg Ala Leu Tyr His Leu Asn Gin Arg Arg Gly Phe Leu Ser Asn 145 150 155 160 Arg Lys Glu Ala Thr Lys Glu Ser Glu Gly Thr Val Lys Glu Gly Ile 165 170 175 Ser Ser Leu Ser Lys Asp Met Lys Asp Ser Gly Cys Glu Tyr Leu Gly 180 185 190 Glu Tyr Phe Tyr Gin Leu Tyr Gin Gin Gly Lys Lys Ile Arg Asn His 195 200 205 Tyr Thr Ala Arg Lys Glu His Tyr Leu Lys Glu Phe Lys Ala Ile Cys 210 215 220 Ser Lys Gin Glu Leu Asp Asp Ala Leu Ile Glu Lys Leu Glu Lys Ala 225 230 235 240 Ile Phe Asp Gin Arg Pro Leu Lys Ser Gin Lys Gly Gin Val Gly Thr 245 250 255 Page 703 of 3790 Cys Thr Phe Glu Lys Gly Lys Ser Arg Cys Pro Ser Ser His Pro Leu 260 265 270 Tyr Glu Asp Phe Arg Met Tyr Ser Phe Ile Asn Asn Ile Lys Val Gin 275 280 285 Val Asp Thr Leu Tyr Asp Lys Gly Glu Arg Ser Leu Thr Asp Glu Glu 290 295 300 Lys Gin Leu Ile Ile Pro Leu Phe Lys Arg Lys Ser Lys Arg Thr Phe 305 310 315 320 Pro Phe Glu Asp Ile Ala Lys Lys Ile Ala Gly Lys Asn Asn Tyr Cys 325 330 335 Tyr Ile Lys Ser Asn Glu Glu Lys Ala Tyr Lys Phe Asn Tyr Gin Met 340 345 350 Asp Thr Gin Val Ser Gly Ser Pro Val Asn Ala Gin Leu Glu Glu Ile 355 360 365 Phe Gly Glu Asp Trp Leu Ser Ser Val Cys Glu Val Tyr Thr Leu Ala 370 375 380 Asn Asn Lys Ser Arg Phe Gin Ile Met Asn Asp Val Trp His Val Leu 385 390 395 400 Phe Phe Tyr Asp Asp Glu Asp Lys Leu Lys Glu Phe Ala Lys Asp Arg 405 410 415 Leu Gin Leu Asp Asp Glu Leu Ala Glu Lys Phe Ser Lys Ile Ser Ile 420 425 430 Pro Asn Asp Tyr Ala Ala Leu Ser Leu Lys Ala Ile Arg Lys Ile Met 435 440 445 Pro Tyr Leu Arg Asp Tyr Gly Leu Ile Tyr Ser Glu Ala Val Phe Leu 450 455 460 Ala Asn Leu Val Asp Val Leu Pro Gin His Val Trp Gly Ile Lys Glu 465 470 475 480 Met Arg Glu Ala Ala Ile Glu Asn Val Ile Asp Val Met His Ser Tyr 485 490 495 Asp Lys Asn Asn Ile Asp Gly Ile Thr Leu Glu Gly Cys Val Lys Thr 500 505 510 Page 704 of 3790 Phe Leu Lys Glu Arg Tyr Gin Val Ser Asp Asp Asn Leu Lys Lys Leu 515 520 525 Tyr His Pro Ser Met Leu Asp Pro Tyr Pro Arg Gin Arg Pro Asn Asp 530 535 540 Glu Gly Val Phe Gin Leu Gly Ser Pro Arg Ile Ser Ser Val Lys Asn 545 550 555 560 Pro Met Ala Met His Ser Leu Phe Arg Leu Arg Lys Val Val Asn Leu 565 570 575 Met Leu Lys Lys Gly Tyr Ile Thr Pro Asp Thr Lys Val His Ile Glu 580 585 590 Phe Ser Arg Asp Leu Asn Asp Ala Asn Lys Arg Trp Ala Ile Gin Thr 595 600 605 Trp Gin Arg Glu Asn Glu Lys Glu Arg Glu Arg Cys Arg Lys Glu Ile 610 615 620 Glu Lys Tyr Ile Ala Ser Pro Ser Asp Thr Asp Ile Leu Lys Tyr Gin 625 630 635 640 Leu Trp Glu Glu Gin Asn His Lys Cys Leu Tyr Thr Gly Asp Glu Ile 645 650 655 Arg Ile Thr Asp Phe Leu Gly Asp Asn Pro Lys Tyr Asp Ile Glu His 660 665 670 Thr Ile Pro Arg Ser Ala Gly Gly Asp Ser Thr Lys Met Asn Leu Thr 675 680 685 Leu Cys Ser Ser Arg Phe Asn Arg Asp Glu Lys Lys Thr Lys Leu Pro 690 695 700 Ala Glu Leu Val Asn His Asp Glu Ile Leu Glu Arg Ile Ser Asn Trp 705 710 715 720 Lys Glu Lys Tyr Glu Asp Ile Asp Lys Gin Ile Arg Lys Ile Ser Thr 725 730 735 Lys Gly Ala Thr Ser Lys Glu Asp Lys Asp Ser Lys Ile Arg Arg Arg 740 745 750 His Tyr Leu Ile Leu Gin Arg Asp Tyr Trp Arg Gly Lys Tyr Gin Arg Page 705 of 3790 Page 706 of 3790 Page 707 of 3790 Met Gly Lys Arg His Asn Ser Asn Met Ala Lys Lys Lys Ile Ser Tyr 15 10 15 Arg Ile Gly Ile Asp Val Gly Leu Asn Ser Thr Gly Leu Ala Ala Ile 20 25 30 Glu Val Asp Asp Asp Gly Ala Pro Ile Arg Ile Leu Asn Thr Met Ser 35 40 45 Val Ile His Asp Gly Gly Val Asp Pro Asp Ala Ala Lys Val Arg Gly 50 55 60 Thr Arg Leu Ala Ile Ser Gly Ile Ala Arg Arg Thr Arg Arg Met Arg 65 70 75 80 Arg Arg Arg Ala Lys Arg Leu Asp Arg Leu Glu Gin Ile Leu Glu Lys 85 90 95 Tyr Gly Tyr Thr Asp Thr Glu Pro Val Leu Glu Glu Pro Tyr Gly Pro 100 105 110 Trp Ile Cys Arg Ala Glu Leu Ala Asp Gly Phe Ile Asn Asp Asp Glu 115 120 125 Gin Arg Arg Met Met Ile Gly Ile Ala Ile Arg His Ile Ala Arg His 130 135 140 Arg Gly Trp Arg Asn Pro Tyr Gin Asn Val Arg Ala Leu Leu Asn Ile 145 150 155 160 Asp Asp Ser Asp Leu Ser Glu Glu Tyr Lys Asn Leu Lys Glu Lys Val 165 170 175 Gin Asp Gin Ile Asn Asp Gly Lys Asp Leu Pro Asn Phe Thr Pro Ser 180 185 190 Gin Leu Val Arg Asp Tyr Leu Asp Asn Phe Ser Gly Gin Pro Ala Ala 195 200 205 Arg Ile Arg Thr Gly Lys Ala Gly Pro Arg Gly Asn Arg Arg Asp Ala 210 215 220 Val Gly Ile Leu Pro Gin Arg Met Arg Gin Ser Asp Tyr Ala Tyr Glu 225 230 235 240 Leu Gin Arg Ile Phe Asp Met Gin Lys Ile Gly Arg Asp Glu Ala Gin 245 250 255 Page 708 of 3790 Glu Leu Leu Met Ala Val Phe Glu Ala Lys Ser Pro Lys Gly Ser Ala 260 265 270 Glu Lys Arg Ile Gly Lys Asp Pro Leu Thr Gly Lys Lys Arg Ala Leu 275 280 285 Lys Ala Ser Leu Ala Phe Gin Lys Tyr Arg Ile Val Ala Thr Ile Thr 290 295 300 Asn Leu Arg Ile Lys Thr Gly Thr Gly Ser Glu Arg Met Leu Ser Pro 305 310 315 320 Thr Glu Leu Asn Asp Ile Tyr Thr Tyr Leu Leu Arg Val Gin Asp Asp 325 330 335 Asn His Leu Pro Thr Trp Glu Asp Ile Cys Glu Glu Val Leu His Ile 340 345 350 Gly Arg Tyr Gin Leu Ala Gly Ile Gly Lys Thr Phe Glu Gly Gly Glu 355 360 365 Arg Ile Ser Asn Met Pro Pro Val Ile Gin Thr Ser Leu Ala Ile His 370 375 380 Gly Leu Ser Glu Gly Thr Leu Ala Glu Lys Leu Thr Lys Trp Trp Asp 385 390 395 400 Lys Ala Asp Asp Asp Ser Arg Glu Ser Met Ile Lys Leu Leu Ser Asn 405 410 415 Thr Val Asp Ile Asp Arg Val Asn Glu Val Asp Glu Asn Phe Ala Ser 420 425 430 Ala Leu Asp Phe Ile Asp Ser Leu Asp Asp Glu Glu Leu Thr Lys Leu 435 440 445 Asp Lys Ile Ala Leu Pro Arg Gly Arg Ala Ala Tyr Ser Glu Glu Ala 450 455 460 Leu Asn Lys Leu Thr Ala Asp Met Leu Asn Thr Gly Asp Asp Leu Phe 465 470 475 480 Ser Ala Arg Gin Arg Ile Tyr His Val Asn Asn Ser Trp Arg Pro Pro 485 490 495 Gin Pro Pro Ile Gly Glu Pro Leu Gly Asn Pro Ala Val Asp Arg Val 500 505 510 Page 709 of 3790 Leu Lys Ile Thr Asn Arg Tyr Leu Met Asn Cys Leu Asn Arg Trp Gly 515 520 525 Gin Pro Arg Arg Val Thr Ile Glu His Thr Arg Ser Gly Phe Thr Ser 530 535 540 Val Lys Gin Ala Thr Glu His Gin Lys Ile Ser Asp Lys Arg Ala Glu 545 550 555 560 Tyr Arg Arg Asp Ile Val Lys Gin Leu Glu Glu Ala Gly Val Glu Ser 565 570 575 Val His Glu Tyr Asp Ile Arg Arg Trp Glu Ala Val Gin Arg Gin Asn 580 585 590 Gly Gin Cys Leu Tyr Cys Gly Arg Asp Ile Thr Phe Lys Thr Cys Glu 595 600 605 Met Asp His Ile Val Pro Arg Lys Gly Pro Gly Ser Thr Asn Thr Arg 610 615 620 Thr Asn Phe Ala Ala Val Cys Pro Glu Cys Asn Arg Met Lys Ser Asn 625 630 635 640 Ile Pro Phe Ala Ser Trp Ala Glu Thr Lys Glu Ala Lys Asp Arg Gly 645 650 655 Val Ser Leu Asp Lys Ala Ile Lys Gin Val Arg Phe Phe Asn Phe Thr 660 665 670 Lys Asn Glu Tyr Ser Pro Gin Ala Gin Arg Asn Phe Lys Lys Ser Met 675 680 685 Ile Glu Arg Leu Lys Gin Lys Thr Ser Asp Glu Pro Leu Asp Asn Arg 690 695 700 Ser Ile Glu Ser Val Ser Trp Met Ala Asp Glu Leu Tyr Lys Arg Ile 705 710 715 720 Asp Trp Tyr Phe Asn His Glu Gin Tyr Glu Thr Ser Lys Lys Ala Ile 725 730 735 Asn Asp Asp Lys Asp Asn Leu Ser Gly Thr Gin Val Val Val Tyr Pro 740 745 750 Gly Ser Ile Thr Ala Glu Ala Arg Asn Ala Ala Gly Leu Gly Gly Asn Page 710 of 3790 Page 711 of 3790 146 1371 PRT Gordonibacter pamelaeae 146 Met Asn Leu Arg Asn Val Glu Ser Tyr Gin Val Gly Leu Asp Ile Gly 15 10 15 Thr Gly Ser Val Gly Trp Ala Val Leu Asp Asp Asn Gly Asp Leu Cys 20 25 30 Page 712 of 3790 Arg Phe Lys Gly Lys Pro Thr Trp Gly Ser Arg Val Phe Pro Thr Ala 35 40 45 Glu Thr Ala Ala Glu Ala Arg Val His Arg Gly Gin Arg Arg Arg Tyr 50 55 60 Asp Arg Arg Arg Gin Arg Ile Asp Leu Leu Gin Arg Phe Phe Ala Asp 65 70 75 80 Glu Val Ala Lys Val Asp Pro Glu Phe Phe Ile Arg Leu Asn Gin Ala 85 90 95 Arg Leu His Pro Glu Asn Arg Asp Pro Ala His Ala Asp Tyr Arg Trp 100 105 110 Pro Leu Phe Asn Gly Ser Asn Phe Thr Glu Lys Asp Tyr Tyr Arg Gin 115 120 125 Phe Pro Thr Ile Tyr His Leu Arg Ala His Leu Leu Lys Ser Asp Glu 130 135 140 Pro Ala Asp Ile Arg Leu Val Tyr Leu Ala Leu His Asn Ile Val Lys 145 150 155 160 His Arg Gly Asn Phe Leu His Gin Asp Asn Pro Ser Leu Ser Ala Arg 165 170 175 Asn Ala Asn Val Gly Asp Ala Val Glu Ala Leu Cys Leu Ala Leu Asp 180 185 190 Glu Trp Cys Gly Ala His Asp Val Glu Cys Ala Cys Asp Glu Ala Ala 195 200 205 Leu Ala Glu Ala Leu Gly Asp Ala Ser Leu Arg Pro Gly Glu Lys Arg 210 215 220 Glu Arg Ala Glu Ala Ala Leu Gly Val Glu Lys Ala His Lys Lys Leu 225 230 235 240 Ala Lys Ala Val Ser Ser Ala Val Val Gly Tyr Ala Ala Glu Phe Gly 245 250 255 His Val Phe Phe Ala Glu Ser Glu Gly Ser Lys Phe Ala Leu Ser Asn 260 265 270 Asp Glu Lys Val Glu Ala Tyr Val Cys Pro Asp Glu Gly Arg Asp Leu 275 280 285 Page 713 of 3790 Phe Asp Ala Met Arg Ala Val His Ser Ser Tyr Val Leu Met Gly Ile 290 295 300 Leu Ser Glu Ala Gin Gly Glu Leu Leu Ser Val Cys Lys Val Gly Glu 305 310 315 320 Tyr Glu Arg Tyr Lys Arg Asp Leu Glu Thr Leu Lys Ser Leu Val Arg 325 330 335 Ala Tyr Gly Pro Glu Arg Tyr Asp Glu Phe Phe Cys Gly Pro Phe Tyr 340 345 350 Glu Gly Thr Arg Asp Tyr Asp Pro Gly Lys Ala Gin Gly Tyr Thr Lys 355 360 365 Tyr Asn Leu Gly Ala Ser Lys Leu Ser His Glu Asp Phe Leu Lys Glu 370 375 380 Val Gin Lys Leu Leu Lys Asp Ile Gly Ala Gin Ala Asp Glu Arg Tyr 385 390 395 400 Ala Asp Ile Glu Arg Ala Ile Glu Ala Gly Ala Phe Leu Arg Arg Leu 405 410 415 Lys Thr Ser Asp Asn Gly Thr Ile Pro Tyr Gin Leu His Leu Glu Glu 420 425 430 Met Asp Ala Ile Ile Glu Arg Gin Ala Ala Phe Tyr Pro Phe Leu Ala 435 440 445 Gin Glu Lys Asp Lys Leu Lys Ser Leu Val Ser Phe Arg Ile Pro Tyr 450 455 460 Tyr Val Gly Pro Leu Thr Gin Lys Asn Ala Ala Arg Asp Gly Lys Gly 465 470 475 480 Glu Ala Arg Phe Ala Trp Ser Ser Arg Lys Pro Gly Met Glu Asp Ala 485 490 495 Arg Val Tyr Pro Trp Asn Trp Glu Asp Val Ile Asp Lys Asp Gin Ser 500 505 510 Ala Glu Asp Phe Ile Arg Arg Met Thr Gly Thr Cys Thr Tyr Leu Lys 515 520 525 Gly Glu Pro Val Leu Ala Arg Cys Ser Leu Asp Tyr Glu Leu Phe Cys 530 535 540 Page 714 of 3790 Val Leu Asn Glu Leu Ala Gly Ala Arg Trp Thr Gin Asp Gly Asp Lys 545 550 555 560 Ser Tyr Arg Phe Asp Ala Ala Asp Arg Leu Gly Ile Val Glu Asp Leu 565 570 575 Phe Lys Lys Arg Lys Arg Val Thr Tyr Glu Ala Ala Glu Lys Trp Leu 580 585 590 Ala Arg Thr His Gly Pro Glu Ser Gly Lys Ser Ala Gly Gly Ala Tyr 595 600 605 His Val Ser Gly Gly Gin Gly Glu Asp Ala Phe Glu Ser Gin Leu Ser 610 615 620 Ser His Tyr Asp Phe Cys Lys Ile Leu Gly Val Asp Glu Leu Ser Asp 625 630 635 640 Ala Asp Glu Ala Met Ala Glu Asp Ile Ile Leu Trp Asn Thr Val Phe 645 650 655 Glu Asp Arg Ser Ile Leu Lys Arg Lys Ile Lys Leu Ala Tyr Gly Asp 660 665 670 Arg Leu Gly Asp Ala Gin Val Arg Lys Leu Cys Gin Lys Arg Tyr Thr 675 680 685 Gly Trp Gly Arg Leu Ser Gly Glu Leu Leu Arg Gly Leu Arg Ser Ala 690 695 700 Thr Asp Asn Gly Pro Lys Thr Ile Met Asp Ile Leu Leu Glu Gly Asp 705 710 715 720 Pro Asn His Ala Arg Arg Met Gly Ala Ala Met Asn Leu Met Glu Ile 725 730 735 Leu His Asp Asp Leu Leu Glu Phe Gin Ala Lys Ile Asp Glu His Asn 740 745 750 Arg Glu Arg Ala Leu Ala Val Gly Gly Met Ser Val Asp Glu Val Thr 755 760 765 Gly Ser Pro Ala Leu Arg Arg Gly Ile Asn Gin Ala Leu Arg Val Val 770 775 780 Asp Glu Ile Ala Gly Ile Ala Gly Lys Pro Pro Ala His Ile Tyr Val Asp Phe His His Ala His Asp Ala Tyr Leu Ala Cys Gin Val Gly 1010 1015 1020 Arg Phe Val Gin Tyr Arg His Ser Ala Val Tyr Ser Glu Pro Val 1025 1030 1035 Page 717 of 3790 Leu Gly Leu 1370 147 1388 PRT Zunongwangia profunda 147 Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Asn Glu Ala Glu Asn Glu Lys Glu Ile Ser Lys 20 25 30 Lys Leu Gly Val Arg Val Asn Pro Leu Thr Ile Asp Glu Lys 35 40 45 Ile Ile Thr Asn Phe Glu Lys 50 Gly Arg Pro Leu Ser Thr Asn Ala Asp Arg 60 Thr Leu Lys Arg Gly Ala Arg Arg Asn Leu Gin Arg Tyr Lys Leu Arg Arg Glu Asn 80 Leu Ile Glu Ile Leu 85 Ile Asp Asn His Ile Ile Thr Lys Glu Thr Pro 95 Leu Thr Glu Ile Gly Lys Gly Thr Thr Tyr Gin Thr Leu Ser Leu Arg 100 105 110 Page 718 of 3790 Ala Lys Ala Val Arg Glu Arg Ile Asp Leu Glu Asp Phe Ala Lys Val 115 120 125 Leu Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 130 135 140 Ser Asn Asp Glu Glu Gly Gin Ala Ile Asp Gly Met Ala Ile Ala Lys 145 150 155 160 Glu Leu Tyr Glu Arg Gly Ile Thr Pro Gly Gin Tyr Val Leu Glu Leu 165 170 175 Leu Glu Asn Asp Arg Lys Tyr Ile Pro Asp Phe Tyr Arg Ser Asp Leu 180 185 190 Lys Gin Glu Phe Asn Lys Ile Trp Asn Asn Gin Lys Thr Phe Tyr Pro 195 200 205 Glu Ile Leu Thr Asp Glu Leu Phe Lys Glu Leu Asp Gly Lys Asn Lys 210 215 220 Ser Gin Thr Trp Ala Ile Cys Gin Lys Pro Phe Asn Ile Lys Gly Ile 225 230 235 240 Lys Arg Ile Thr Lys Gly Arg Glu Lys Thr Ile Glu Asn Tyr His Trp 245 250 255 Arg Val Lys Gly Leu Ser Gly Lys Leu Asn Leu Glu Lys Leu Ala Ile 260 265 270 Ile Leu Gin Glu Ile Asn Asn Asp Ile Asn Gin Ser Ser Gly Tyr Leu 275 280 285 Gly Gly Ile Ser Asp Lys Ser Lys Lys Leu Tyr Leu Asn Lys Glu Thr 290 295 300 Val Gly Glu Phe Leu Tyr Lys Gin Ile Ala Lys Asn Pro His Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg His Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Gin Ile Trp Lys Thr Gin Ser Asn Phe Asn Ala Asn Leu Thr Asp Glu 340 345 350 Leu Lys Gin Glu Ile Arg Asp Val Ile Ile Phe Tyr Gin Arg Lys Ile 355 360 365 Page 719 of 3790 Lys Ser Gin Lys Ser Leu Ile Ser Phe Cys Gin Phe Glu Ser Trp Glu 370 375 380 Gin Glu Tyr Phe Asp Lys Glu Thr Gly Lys Thr Lys Thr Arg Thr Val 385 390 395 400 Gly Arg Arg Val Ile Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys 405 410 415 Ile Trp Gin Asn Leu Asn His Leu Val Phe Thr Asn Ser Glu Thr Asp 420 425 430 Glu Lys Ile Glu Ile Lys Glu Val Glu Gin Glu Ile Arg Lys Glu Leu 435 440 445 Phe Glu Glu Leu Asn Leu Arg Gly Asp Leu Asn Pro Asn Asp Leu Leu 450 455 460 Lys Ile Leu Arg Ser Gin Phe Lys Ile Gly Lys Leu Ser Asn Trp Lys 465 470 475 480 Cys Asn Phe Glu Lys Ile Glu Gly Asn Arg Thr Asn Ala Ala Leu Phe 485 490 495 Asn Ile Tyr Gin Lys Ile Ser Asp Phe Glu Gly Tyr Gly Ile Asp Trp 500 505 510 Asn Lys Ser Asn Ala Lys Lys Ile Arg Lys Glu Leu Lys Ala Thr Phe 515 520 525 Pro Glu Ile Gly Ile Asp Ala Ser Ile Leu Glu Phe Asp Ala Tyr Lys 530 535 540 Lys Gin Leu Thr Asn Gin Ser Ser Tyr Glu Leu Trp His Leu Leu Tyr 545 550 555 560 Ser Ala Glu Glu Asp Phe Lys Ile Ser Glu Gin Asp Lys Leu Ile Tyr 565 570 575 Gly Asn Ser Ser Val Ser Leu Lys Lys Lys Leu His Leu Lys Phe Gly 580 585 590 Phe Asn Pro Glu Tyr Ala Lys Met Leu Ala Asn Leu Ser Leu Met Ser 595 600 605 Asp Tyr Gly Asn Leu Ser Ala Lys Ala Ile Lys Lys Ile Leu Pro Tyr Page 721 of 3790 Gin Glu Ala Val Leu His His Leu Lys Lys Tyr Asp Asn Asn Glu 1100 1105 1110 Page 722 of 3790 Page 723 of 3790 148 1082 PRT Methylosinus trichosporium 148 Page 724 of 3790 Asp Glu Ser Phe Val Leu Arg Gin Thr Pro Thr Lys Asn Gly Ala Ser 180 185 190 Glu Ile Val Arg Arg Phe Arg Asn Arg Glu Gly Asp Tyr Ser Arg Ser 195 200 205 Leu Leu Arg Asp Asp Leu Ala Ala Glu Met Arg Ala Leu Phe Thr Ala 210 215 220 Gin Ala Arg Phe Gin Ser Ala Ile Ala Thr Ala Asp Leu Gin Thr Ala 225 230 235 240 Phe Thr Lys Ala Ala Phe Phe Gin Arg Pro Leu Gin Asp Ser Glu Lys 245 250 255 Leu Val Gly Pro Cys Pro Phe Glu Val Asp Glu Lys Arg Ala Pro Lys 260 265 270 Arg Gly Tyr Ser Phe Glu Leu Phe Arg Phe Leu Ser Arg Leu Asn His 275 280 285 Val Thr Leu Arg Asp Gly Lys Gin Glu Arg Thr Leu Thr Arg Asp Glu 290 295 300 Leu Ala Leu Ala Ala Ala Asp Phe Gly Ala Ala Ala Lys Val Ser Phe 305 310 315 320 Thr Ala Leu Arg Lys Lys Leu Lys Leu Pro Glu Thr Thr Val Phe Val 325 330 335 Gly Val Lys Ala Asp Glu Glu Ser Lys Leu Asp Val Val Ala Arg Ser 340 345 350 Gly Lys Ala Ala Glu Gly Thr Ala Arg Leu Arg Ser Val Ile Val Asp 355 360 365 Ala Leu Gly Glu Leu Ala Trp Gly Ala Leu Leu Cys Ser Pro Glu Lys 370 375 380 Leu Asp Lys Ile Ala Glu Val Ile Ser Phe Arg Ser Asp Ile Gly Arg 385 390 395 400 Ile Ser Glu Gly Leu Ala Gin Ala Gly Cys Asn Ala Pro Leu Val Asp 405 410 415 Ala Leu Thr Ala Ala Ala Ser Asp Gly Arg Phe Asp Pro Phe Thr Gly Page 726 of 3790 Asp Met Lys Gly Phe Lys Lys Arg Asn Tyr Lys Leu Arg Asn Ala Glu 675 680 685 Glu Ala Ala Ala Lys Phe Arg Asn Arg Asn Leu Asn Asp Thr Arg Trp 690 695 700 Ala Cys Arg Leu Leu Ala Glu Ala Leu Lys Gin Leu Tyr Pro Lys Gly 705 710 715 720 Glu Lys Asp Lys Asp Gly Lys Glu Arg Arg Arg Val Phe Ser Arg Pro 725 730 735 Gly Ala Leu Thr Asp Arg Leu Arg Arg Ala Trp Gly Leu Gin Trp Met 740 745 750 Lys Lys Ser Thr Lys Gly Asp Arg Ile Pro Asp Asp Arg His His Ala 755 760 765 Leu Asp Ala Ile Val Ile Ala Ala Thr Thr Glu Ser Leu Leu Gin Arg 770 775 780 Ala Thr Arg Glu Val Gin Glu Ile Glu Asp Lys Gly Leu His Tyr Asp 785 790 795 800 Leu Val Lys Asn Val Thr Pro Pro Trp Pro Gly Phe Arg Glu Gin Ala 805 810 815 Val Glu Ala Val Glu Lys Val Phe Val Ala Arg Ala Glu Arg Arg Arg 820 825 830 Ala Arg Gly Lys Ala His Asp Ala Thr Ile Arg His Ile Ala Val Arg 835 840 845 Glu Gly Glu Gin Arg Val Tyr Glu Arg Arg Lys Val Ala Glu Leu Lys 850 855 860 Leu Ala Asp Leu Asp Arg Val Lys Asp Ala Glu Arg Asn Ala Arg Leu 865 870 875 880 Ile Glu Lys Leu Arg Asn Trp Ile Glu Ala Gly Ser Pro Lys Asp Asp 885 890 895 Pro Pro Leu Ser Pro Lys Gly Asp Pro Ile Phe Lys Val Arg Leu Val 900 905 910 Thr Lys Ser Lys Val Asn Ile Ala Leu Asp Thr Gly Asn Pro Lys Arg 915 920 925 Page 727 of 3790 149 1186 PRT Gardnerella vaginalis 149 Met Glu Gly Asn Ile Ser Tyr Ala Ile Gly Ile Asp Val Gly Leu Asn 15 10 15 Ser Val Gly Leu Ala Ala Ile Arg Leu Asp Asn Asn Gly Glu Pro Ile 20 25 30 Arg Ile Leu Lys Ala Met Ser Val Ile His Asp Ala Gly Ile Asp Pro 35 40 45 Asn Gly Ala Lys Glu Ser Asp Thr Arg Lys Ala Ile Ser Gly Val Ala 50 55 60 Page 728 of 3790 Arg Arg Val Arg Arg Leu Tyr Arg Gin Arg Arg Arg Arg Leu Gin Lys 65 70 75 80 Leu Asp Phe Leu Leu His Ser Leu Gly Phe Pro Val Val Glu Asn Lys 85 90 95 Asp Leu Asp Phe Ser Asp Ser Phe Thr Pro Trp Ile Phe Arg Ala Lys 100 105 110 Leu Ala Asp Glu Tyr Ile Ala Asp Glu Lys Gin Arg Lys Gin Met Leu 115 120 125 Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 130 135 140 Tyr Gin Ser Ile Lys Ser Met Thr Gin Glu Thr Glu Tyr Ser Glu Phe 145 150 155 160 Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Phe Ala Pro Gly Val Ser 165 170 175 Cys Glu Gly Ser Thr Pro Ala Gin Leu Val Arg Asp Tyr Leu Leu Ser 180 185 190 Gin Gin Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Asp Asp Arg 195 200 205 Arg Lys Asn His Pro Asn Ser Leu Asp Pro Val Leu Pro Arg Lys Leu 210 215 220 Met Gin Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gin 225 230 235 240 His Ile Asp Asn Lys Tyr Val Arg Glu Gin Ile Ile Asn Ala Val Phe 245 250 255 Tyr Ala Lys Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 260 265 270 Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 275 280 285 Gin Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 290 295 300 Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gin Ser Val Tyr 305 310 315 320 Page 729 of 3790 Lys Leu Leu Thr Thr Ser Thr Asp Glu Tyr Ser Lys Glu Lys Ser Ala 325 330 335 Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 340 345 350 Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gin Ile Glu Asp Gly Glu 355 360 365 Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Leu 370 375 380 Tyr Ala Asn Ala Lys Ser Leu Lys Gin Ser Leu Ile Thr Trp Trp Leu 385 390 395 400 Ala Ala Asn Arg Thr Gin Glu Asp Lys Glu Ala Phe Ile Glu Ile Leu 405 410 415 Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gin 420 425 430 Asp Lys Tyr Gly Ser Val Ile Ala Phe Ile Asp Ser Met Asp Glu Thr 435 440 445 Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asn Gly Arg Ala Ala 450 455 460 Tyr Ser Leu Glu Thr Leu Asp Lys Leu Asn Lys Gin Met Leu Glu Thr 465 470 475 480 Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 485 490 495 Asn Trp Arg Pro Ser Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 500 505 510 Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 515 520 525 Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 530 535 540 Ser Gly Phe Gin Ser Lys Lys Met Ala Asn Ser Tyr Lys Lys Leu Leu 545 550 555 560 Asp Lys Arg Thr Glu Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn Page 731 of 3790 Asp Glu Ile Ile Val Asp Phe Ser His Val Lys Leu Ser Gly Tyr 1055 1060 1065 Page 732 of 3790 150 1434 PRT Bacteroidetes orał 150 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Tyr Val Lys Gin Ala Gin Asn Asp Ser Glu Lys Ser Glu Ile Ala 20 25 30 Glu Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Thr Asn 35 40 45 Phe Glu Lys Gly Lys Pro Ile Ser Thr Asn Ala Asp Arg Thr Leu Lys 50 55 60 Arg Gly Ala Arg Arg Asn Leu Gin Arg Tyr Lys Leu Arg Arg Gin Glu 65 70 75 80 Leu Ile Glu Leu Leu Lys Asp Tyr Gin Val Ile Ser Asp Lys Thr Ile 85 90 95 Page 733 of 3790 Leu Ala Glu Asp Gly Lys Glu Thr Thr Phe Glu Thr Leu Arg Leu Arg 100 105 110 Val Lys Ser Ala Lys Glu Gin Val Ser Leu Glu Glu Leu Ala Arg Ile 115 120 125 Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 130 135 140 Lys Asn Glu Asp Glu Gly Gin Leu Ile Asp Gly Met Glu Ile Ala Arg 145 150 155 160 Arg Leu Tyr Asp Glu Asn Leu Thr Thr Gly Gin Leu Ser Leu Gin Leu 165 170 175 Leu Lys Glu Gly Lys Lys Ser Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 180 185 190 Gin His Glu Leu Asp Lys Val Trp Asn Phe Gin Lys Gin Phe His Pro 195 200 205 Asp Ile Leu Thr Asp Glu Phe Tyr Thr Ser Ile Gin Gly Lys Gly Gin 210 215 220 Lys Ala Thr Arg Glu Ser Phe Ser Ser Lys Tyr Gly Ile Asp Thr Ala 225 230 235 240 Glu Asn Lys Gly Ser Arg Glu Glu Lys Lys Leu Gin Ala Tyr Gin Trp 245 250 255 Arg Ala Asp Ala Thr His Lys Glu Leu Thr Lys Glu Glu Leu Ala Phe 260 265 270 Val Ile Thr Glu Ile Asn Asn Asn Ile Asn Asn Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Ile Phe Ala Asn Glu Thr 290 295 300 Val Gly Glu Tyr Leu Trp Lys Gin Ile Gin Asn Asp Pro His Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Phe Asp Glu Phe Glu 325 330 335 Arg Ile Trp Glu Thr Gin Ser Gly Phe Tyr Pro Gin Ile Leu Thr Glu 340 345 350 Page 734 of 3790 Ser Leu Lys Asn Glu Leu Arg Asp Ile Leu Ile Phe Tyr Gin Arg Lys 355 360 365 Leu Lys Ser Gin Lys Ala Leu Val Ser Ile Cys Glu Phe Glu Ser Lys 370 375 380 Glu Ile Pro Leu Lys Asp Lys Gin Gly Asn Pro Ile Ser Lys Asn Gly 385 390 395 400 Ile Pro Val Thr Lys Leu Val Gly Pro Lys Val Ala Pro Lys Ser Ser 405 410 415 Pro Leu Phe Gin Glu Phe Lys Ile Trp Gin Asn Leu Asn Asn Val Leu 420 425 430 Val Arg Pro Lys Gly Ser Arg Lys Arg Lys Val Thr Thr Asn Gin Gin 435 440 445 Ser Thr Leu Leu Glu Gly Gin Glu Pro Val Phe Glu Leu Asn Leu Glu 450 455 460 Gin Lys Glu Leu Leu Phe Glu Glu Leu Asn Leu Lys Gly Asn Leu Lys 465 470 475 480 Thr Asp Tyr Cys Leu Glu Leu Ile Gly Tyr Ser Ala Lys Glu Trp Glu 485 490 495 Met Asn Tyr Pro Thr Leu Glu Gly Asn Lys Thr Asn Lys Ala Leu Tyr 500 505 510 Glu Ala Tyr Leu Lys Ile Ile Asp Ser Glu Gly Tyr Asp Ala Lys Lys 515 520 525 Leu Leu Lys Val Lys Thr Asp Lys Asp Asp Ile Asn Leu Asp Asp Ile 530 535 540 Lys Val Ser Ala Ser Glu Ile Lys Thr Met Ile Ser Asp Ile Phe Asn 545 550 555 560 Glu Leu Gly Ile Asn Thr Lys Ile Leu Asp Phe Asp Ala Glu Leu Glu 565 570 575 Arg Lys Gin Phe Glu Ala Gin Ala Ser Tyr Arg Leu Trp His Leu Leu 580 585 590 Tyr Ser Tyr Glu Gly Asp Asp Ser Lys Ser Gly Asn Glu Leu Leu Tyr Page 735 of 3790 595 600 605 Arg Leu Leu Glu Asp Lys Phe Gly Phe Lys Arg Glu His Ser Lys Thr 610 615 620 Leu Ala Asn Val Ser Leu Leu Ser Asp Tyr Gly Asn Leu Ser Thr Lys 625 630 635 640 Ala Ile Arg Thr Ile Tyr Pro Tyr Ile Lys Glu Asn Lys Phe Ser Thr 645 650 655 Ala Cys Glu Leu Ala Gly Tyr Arg His Ser Lys Leu Ser Ile Ser Lys 660 665 670 Glu Glu Asn Glu Asn Arg Thr Leu Lys Asp Thr Leu Asp Val Leu Lys 675 680 685 Lys Asn Ser Leu Arg Gin Pro Val Val Glu Lys Ile Leu Asn Gin Met 690 695 700 Ile Asn Leu Ile Asn Glu Leu Ile Glu Lys His Ser Glu Lys Asp Glu 705 710 715 720 Lys Gly Asn Ile Val Lys Tyr Phe Lys Phe Asp Glu Ile His Ile Glu 725 730 735 Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Arg Glu Leu Asp 740 745 750 Ser Lys Val Arg Glu Gly Lys Asp Arg Asn Glu Lys Ile Ile Thr Ile 755 760 765 Leu Lys Ser Glu Phe Gly Leu Pro Tyr Pro Thr Lys Asn Asp Ile Thr 770 775 780 Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Asp Asn Gly Tyr Lys Asp Leu 785 790 795 800 Tyr Thr Asn Thr Tyr Ile Pro Arg Glu Lys Leu Phe Ser Lys Glu Ile 805 810 815 Asp Ile Glu His Ile Ile Pro Lys Ser Arg Leu Phe Asn Asp Ser Phe 820 825 830 Ser Asn Lys Thr Ile Cys Tyr Arg Gin Asp Asn Leu Asn Lys Gly Glu 835 840 845 Page 736 of 3790 Gin Gin Glu Thr Leu Ser Pro Arg Gly Gin Leu His Lys Glu Thr 1085 1090 1095 Page 737 of 3790 Page 738 of 3790 1430 151 1341 PRT Peptoniphilus sp. 151 Page 739 of 3790 Phe Leu Ala Ile His Asn Ile Leu Lys Asn Arg Gly His Phe Leu Leu 115 120 125 Ala Gly Asn Asp Ile Asn Ile Ser Leu Ser Leu Asn Asp Thr Leu Thr 130 135 140 Asp Leu Phe Glu Tyr Leu Lys Ile His Leu Gly Ile Glu Val Glu Phe 145 150 155 160 Glu Asn Lys Leu Lys Asp Ile Glu Lys Ile Ala Leu Asp Lys Asn Leu 165 170 175 Ser Lys Ser Asp Lys Gin Lys Lys Ile Val Gin Leu Leu Glu Thr Asp 180 185 190 Tyr Lys Lys Gin Leu Ala Asp Val Phe Lys Leu Ser Leu Gly Leu Thr 195 200 205 Ala Asn Met Glu Asn Ile Phe Gly Lys Glu Asn Glu Gin Gly Leu Glu 210 215 220 Phe Ile Asn Ala Glu Asn Lys Ile Lys Lys Ile Gin Phe Asp Ser Ser 225 230 235 240 Tyr Glu Glu Asn Ile Ala Glu Phe Asp Gin Phe Tyr Gly Glu Tyr Phe 245 250 255 Glu Ile Ile Asp Ile Cys Lys Lys Ile Tyr Asp Ala Ile Ser Leu Ser 260 265 270 Gin Ile Leu Val Asp Gly Lys Gly Leu Ser Glu Ser Lys Val Leu Ser 275 280 285 Tyr Glu Lys His Lys Glu Asp Leu Lys Leu Leu Lys Lys Val Leu Lys 290 295 300 Asn Ile Asp Lys Ala Tyr Asp Asn Lys Gly Glu Asp Arg Leu Val Tyr 305 310 315 320 Lys Val Leu Lys Glu Asp Lys Asp Lys Gly Thr Asn Tyr Val Asn Tyr 325 330 335 Ser Lys Leu Ser Asn Asn Gly Thr Ala Thr Thr Lys Glu Glu Phe Tyr 340 345 350 Lys Phe Leu Ser Lys Asn Leu Asp Leu Lys Lys Phe Gly Lys Leu Asn Page 740 of 3790 355 360 365 Lys Glu Asp Ile Glu Thr Leu Asp Tyr Ile Asn Ser Glu Ile Leu Leu 370 375 380 Gly Arg Phe Leu Pro Leu Gin Lys Glu Lys Ile Asn Gly Val Ile Pro 385 390 395 400 Tyr Gin Leu Gin Met Lys Glu Leu Thr Gin Ile Leu Asn Asn Ala Ser 405 410 415 Lys Tyr Leu Pro Phe Leu Asn Lys Ile Glu Asp Gly Met Thr Val Lys 420 425 430 Asp Lys Ile Ile Ser Leu Ile Lys Phe Arg Ile Pro Tyr Tyr Val Gly 435 440 445 Pro Leu Asn Glu Tyr Asn Arg Ile Glu Asn Gly Asn Gly Phe Ala Trp 450 455 460 Ile Glu Lys Lys Lys Asn Glu Lys Ile Phe Pro Trp Asn Phe Asn Asp 465 470 475 480 Val Val Asp Ile Glu Lys Ser Ala Glu Lys Phe Ile Asn Asn Leu Thr 485 490 495 Asn Lys Cys Thr Tyr Ile Lys Glu Glu Thr Val Leu Pro Lys Asn Ser 500 505 510 Ile Ile Tyr Ser Lys Phe Met Val Leu Asn Glu Leu Asn Asn Leu Gin 515 520 525 Tyr Gly Asn Lys Lys Leu Asp Ile Glu Leu Lys Met Lys Met Tyr Thr 530 535 540 Asp Leu Phe Leu Glu Lys Lys Asp Asn Arg Lys Val Thr Glu Lys Arg 545 550 555 560 Ile Leu Glu Tyr Phe Arg Ile Asn Gly Ile Asn Asp Gly Lys Glu Lys 565 570 575 Leu Thr Gly Leu Asn Asn Glu Ile His Ala Asp Met Lys Ser Tyr Arg 580 585 590 Asp Met Cys Glu Ile Met Gly Glu Asn Phe Asn Ile Asn Val Ala Glu 595 600 605 Page 741 of 3790 Asn Ile Ile Asn Trp Ile Thr Val Phe His Gly Glu Lys Lys Ile Leu 610 615 620 Ile Asn Lys Ile Lys Asn Val Tyr Gly Lys Met Phe Asn Asp Glu Gin 625 630 635 640 Ile Ser Lys Leu Ser Lys Leu Asn Tyr Ser Asp Trp Gly Arg Leu Ser 645 650 655 Lys Lys Leu Leu Thr Asp Ile Lys Cys Tyr Ile Asp Ala Asp Gly Ile 660 665 670 Asn Phe Pro Val Ser Ile Leu Glu Ala Met Glu Val Ser Asn Lys Asn 675 680 685 Leu Met Glu Leu Leu Ser Asn Lys Tyr Glu Phe Ile Ser Cys Ile Asp 690 695 700 Asp Ile Asn Asn Lys Tyr Phe Gly Asp Arg Asp Ile Ser Ala Ser Glu 705 710 715 720 Leu Ile Asp Glu Leu Tyr Val Ser Pro Ala Val Lys Arg Gly Ile Trp 725 730 735 Gin Ser Val Arg Ile Leu Glu Glu Ile Val Ser Ile Ile Gly His Asn 740 745 750 Pro Lys Lys Ile Phe Ile Glu Met Thr Arg His Asn Glu Glu Lys Val 755 760 765 Gin Lys Ser Ser Arg Arg His Asn Leu Glu Glu Leu Tyr Lys Ala Ile 770 775 780 Arg Lys Asp Pro Glu Tyr Val Glu Leu Ile Lys Glu Phe Asp Ser Thr 785 790 795 800 Thr Asp Thr Asp Ser Phe Lys Ile Lys Lys Leu Tyr Leu Tyr Phe Met 805 810 815 Gin Leu Gly Lys Cys Ala Tyr Ser Lys Glu Lys Ile Asp Phe Asp Lys 820 825 830 Leu Phe Thr Asp Ser Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys 835 840 845 Thr Lys Asp Asp Ser Ile His Asn Asn Leu Val Leu Val Lys Ala Lys 850 855 860 Page 742 of 3790 Page 743 of 3790 Leu Asn Ile Page 744 of 3790 195 200 205 Ile Ile Arg Asp Lys Lys Val Phe Lys Ile Asn Lys Val Lys Ser Ile Page 747 of 3790 Gin Asn Asn Phe Met Gin Ile Val Asn Gin Ser Asp Phe Lys Asp Ala 725 730 735 Ile Ala Val Ala Asn Gin Asn Leu Leu Val Asn Thr Ser Val Glu Asp 740 745 750 Ile Leu Asn Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 755 760 765 Gin Val Val Lys Val Val Asp Asp Ile Val Lys Ala Ala Ser Gly Lys 770 775 780 Val Pro Lys Gin Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Asp Lys 785 790 795 800 Ala Lys Ile Ser Gin Thr Arg Ala Asn Lys Leu Arg Lys Val Tyr Lys 805 810 815 Glu Leu Ser Asn Glu Leu Ala Ser Glu Thr Ile Arg Asn Glu Leu Glu 820 825 830 Arg Val Ala Lys Asp Gin Lys Leu Leu Lys Asp Lys Tyr Tyr Leu Tyr 835 840 845 Phe Met Gin Leu Gly Arg Asp Ala Tyr Thr Gly Glu Pro Ile Asn Ile 850 855 860 Asp Asp Leu Gly Gin Tyr Asp Ile Asp His Ile Leu Pro Gin Ser Phe 865 870 875 880 Ile Lys Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Ala Val 885 890 895 Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Tyr Gly Asn Arg 900 905 910 Met Ala Ala Asp Leu Gly Met Thr Ile Arg His Met Trp Glu Lys Trp 915 920 925 Lys Asp Gin Gly Leu Ile Thr Lys Thr Lys Tyr Asn Asn Leu Ile Ile 930 935 940 Asp Pro Asp Lys Ile Asn Lys Tyr Glu Ser Ser Gly Phe Ile His Arg 945 950 955 960 Gin Leu Val Glu Thr Ser Gin Ile Ile Lys Leu Val Ser Thr Ile Leu 965 970 975 Page 748 of 3790 Gin Ser Lys Tyr Pro Asp Thr Glu Ile Ile Val Val Lys Ala Arg Tyr 980 985 990 Asn His Tyr Leu Arg Lys His Leu Asn Leu Tyr Lys Ser Arg Glu Val 995 1000 1005 Asn Asp Tyr His His Ala Ile Asp Ala Tyr Leu Ser Ala Ile Cys 1010 1015 1020 Gly Asn Leu Leu Tyr Gin Val Tyr Pro Tyr Leu Arg Pro Phe Phe 1025 1030 1035 Val Tyr Gly Gin Tyr Lys Lys Phe Ser Ser Asp Pro Lys Lys Glu 1040 1045 1050 Lys Ile Ile Tyr Asp Lys Thr Arg Lys Tyr Asn Phe Ile Ser Gin 1055 1060 1065 Ile Phe Glu Asn Lys Ser Asn Asp Ile Ile Ser Leu Glu Thr Lys 1070 1075 1080 Lys Lys Val Phe Asp Lys Lys Asp Ile Ile Glu Lys Leu Lys His 1085 1090 1095 Ala Tyr Asn Tyr Lys Tyr Met Leu Val Ser Arg Glu Thr Glu Thr 1100 1105 1110 His Asp Gin Glu Met Phe Lys Met Thr Val Tyr Pro Arg Leu Ser 1115 1120 1125 Arg Asp Thr Lys Lys Ser Arg Asn Leu Ile Ser Lys Lys Lys Asp 1130 1135 1140 Met Pro Thr Glu Ile Tyr Gly Gly Tyr Thr Asn Asn Ser Asp Ala 1145 1150 1155 Tyr Met Val Ile Ala Arg Ile Asn Lys Lys Lys Gly Thr Glu Tyr 1160 1165 1170 Arg Val Phe Gly Val Pro Met Arg Glu Leu Val Asn Leu Arg Lys 1175 1180 1185 Ala Glu Lys Asn Gly Arg Tyr Asn Ala Tyr Leu Lys Gin Val Leu 1190 1195 1200 Glu Pro Glu Ile Met Tyr Ser Lys Asn Gly Lys Lys Asn Lys Thr 153 1426 PRT Sphingobacterium spiritivorum 153 Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Ile Lys Gin Asp Phe Glu Asn Lys Gin Gly Glu Ile Leu Gly Page 751 of 3790 Glu Lys Arg Ser Phe Arg Ala Pro Gly Glu Asn Asp Trp Thr Leu Val 275 280 285 Lys Lys Lys Thr Glu Gin Glu Ile Asp Ser Ser Arg Lys Thr Val Gly 290 295 300 Thr Tyr Ile Tyr Glu Thr Leu Leu Lys Asn Pro Lys Gin Lys Ile Lys 305 310 315 320 Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Thr Glu Leu 325 330 335 Lys Gin Ile Leu Glu Lys Gin Lys Glu Phe His Pro Glu Leu Arg Gin 340 345 350 Asp Asp Leu Tyr Ser Asp Cys Val Arg Glu Leu Tyr Lys Asn Asn Glu 355 360 365 Ala His Gin Leu Thr Leu Ser Lys Lys Asp Phe Val His Leu Phe Met 370 375 380 Glu Asp Ile Ile Phe Tyr Gin Arg Pro Leu Gly Ser Gin Lys Ser Ser 385 390 395 400 Ile Ser Asn Cys Thr Leu Glu Phe Arg Lys Tyr Lys Asp Glu Asn Gly 405 410 415 Thr Glu His Thr Gin Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr 420 425 430 Tyr Gin Glu Phe Arg Ile Trp Gin Trp Met Tyr Asn Leu Asn Ile Tyr 435 440 445 Lys Lys Glu Asp Asp Thr Asn Val Thr Lys Asp Phe Leu Asn Thr Lys 450 455 460 Ala Asp Phe Glu Ser Leu Phe Glu Phe Leu Asn Asn Arg Lys Glu Val 465 470 475 480 Asp Gin Lys Ala Leu Leu Lys His Phe Lys Leu Asn Asp Lys Thr His 485 490 495 Arg Trp Asn Tyr Val Glu Asp Lys Lys Tyr Pro Cys Asn Glu Thr Lys 500 505 510 Thr Met Ile Leu Ser Arg Leu Asp Lys Val Glu Asn Ile Ser Asp Asp 515 520 525 Page 752 of 3790 Phe Leu Thr Arg Glu Met Glu Gin Lys Ile Trp His Ile Ile Tyr Ser 530 535 540 Val Asn Asp Lys Val Glu Tyr Glu Lys Ala Leu Lys Ser Phe Ala Gly 545 550 555 560 Lys Asn Asn Leu Glu Asp Asn Ser Phe Phe Glu Ala Phe Lys Lys Phe 565 570 575 Pro Pro Phe Lys Ser Glu Tyr Gly Ala Phe Ser Glu Lys Ala Ile Lys 580 585 590 Lys Leu Leu Pro Leu Met Arg Met Gly Lys Phe Trp Asn Tyr Asn Asn 595 600 605 Ile Ser Glu Gin Ser Lys Ser Arg Ile Gin Lys Ile Ile Thr Gly Glu 610 615 620 Tyr Asp Glu Asn Ile Lys Asp Lys Val Arg Glu Lys Ala Ile His Leu 625 630 635 640 Thr Thr Glu Thr Asp Phe Gin Gly Leu Gin Leu Trp Leu Val Gin Tyr 645 650 655 Ile Val Tyr Gly Arg His Ser Glu Ala Ala Met Leu Gly Lys Trp Asn 660 665 670 Ser Ala Asp Asp Leu Glu Glu Phe Leu Lys Glu Phe Lys Gin His Ser 675 680 685 Leu Arg Asn Pro Ile Val Glu Gin Val Ile Thr Glu Thr Leu Arg Val 690 695 700 Val Lys Asp Ile Trp Gin Lys Tyr Gly Asn Gly Ala Lys Asp Phe Phe 705 710 715 720 Arg Glu Ile His Ile Glu Leu Gly Arg Glu Met Lys Leu Pro Ala Glu 725 730 735 Glu Arg Glu Arg Leu Thr Arg Gin Ile Ser Glu Asn Glu Asn Thr Asn 740 745 750 Phe Arg Ile 755 Lys Ala Leu Leu Ala 760 Glu Met Met Asp Asp Asn 765 Ser Val Glu Asn Val Arg Pro Phe Ser Pro Met Gin Gin Glu Ile Leu Lys Ile 770 775 780 Page 753 of 3790 Leu Pro Thr Val Pro Val Glu Phe Ser Lys Gly Phe Ser Lys Lys 154 1361 PRT Lactobacillus casei 154 Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser 15 10 15 Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 20 25 30 Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 35 40 45 Page 757 of 3790 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Lys Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Ala Gin His His Glu 325 330 335 Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Thr Ala Lys Ala Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Leu Ala Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Lys Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Arg Tyr 530 535 540 Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 545 550 555 560 Page 758 of 3790 Ser Ile Glu Gin Lys Gin Gin Val Ile Arg Glu Leu Phe Glu Arg His 565 570 575 Asn Ser Val Thr Ile Lys Gin Phe Ala Glu Asn Leu Arg Ala His Gly 580 585 590 Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gin Leu Lys Ser Leu Leu Pro 610 615 620 Asp Ala Ile Asp Asp Pro Ala Lys Gin Ala Asp Ile Glu Asn Ile Ile 625 630 635 640 Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 645 650 655 Lys Glu Ile Asn Trp Leu Asp Ser Gin Thr Ile Thr Lys Leu Ser Asn 660 665 670 Ile Arg Tyr Arg Gly Trp Gly Gin Phe Ser His Lys Phe Leu Asn Gly 675 680 685 Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gin Glu Leu Phe Leu Ser 690 695 700 Asn Asn Asn Leu Met Gin Ile Leu Thr Asp Glu Thr Leu Gin Lys Lys 705 710 715 720 Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 725 730 735 Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 740 745 750 Gin Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gin 755 760 765 Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 770 775 780 Gly Lys Arg Thr Arg Ala Arg Gin His Gin Leu Gin Glu Ile Tyr Ala 785 790 795 800 Asn Ala Ala His Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 805 815 Page 759 of 3790 810 Glu Asp Lys Ile Val Val Lys Asp Thr Gly Glu Val Ile Trp Asp 1040 1045 1050 Page 760 of 3790 Page 761 of 3790 155 1436 PRT Bacteroides fragilis 155 Page 762 of 3790 Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 145 150 155 160 Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gin Leu 165 170 175 Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 180 185 190 Gin Asn Glu Leu Asp Arg Ile Trp Glu Lys Gin Lys Glu Tyr Tyr Pro 195 200 205 Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 210 215 220 Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Asn 225 230 235 240 Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gin Gin Glu Arg 245 250 255 Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 260 265 270 Lys Arg Glu Asn Leu Gin Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 275 280 285 Ser Leu Glu Gin Leu Val Ile Val Phe Gin Glu Met Asn Thr Gin Ile 290 295 300 Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 305 310 315 320 Leu Tyr Phe Asn Lys Gin Thr Val Gly Gin Tyr Gin Met Glu Met Leu 325 330 335 Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gin 340 345 350 Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gin Ala Val Tyr 355 360 365 His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 370 375 380 Ile Phe Tyr Gin Arg Arg Leu Lys Ser Gin Lys Gly Leu Ile Gly Phe 385 390 395 400 Page 763 of 3790 Cys Glu Phe Glu Ser Arg Gin Ile Glu Val Asp Ile Asp Gly Lys Lys 405 410 415 Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 420 425 430 Phe Gin Glu Phe Lys Ile Trp Gin Ile Leu Asn Asn Ile Glu Val Thr 435 440 445 Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 450 455 460 Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gin Leu Glu Leu Asn Gly 465 470 475 480 Ser Arg Arg Leu Cys Gin Glu Glu Lys Glu Leu Leu Ala Gin Glu Leu 485 490 495 Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 500 505 510 Asp Asn Pro Gin Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 515 520 525 Lys Thr Gly Tyr Ala Leu Phe Gin Ala Tyr Ser Lys Met Ile Glu Met 530 535 540 Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 545 550 555 560 Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 565 570 575 Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gin Ser Tyr Tyr Lys 580 585 590 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 595 600 605 Asn Gly Arg Leu Ile Gin Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 610 615 620 Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gin Asp Asp Tyr Gly 625 630 635 640 Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu Page 765 of 3790 Phe Ile Glu Arg Asp Leu Arg Asn Thr Gin Tyr Ile Ala Lys Lys Ala 900 905 910 Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 915 920 925 Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gin Leu Ile Asp Val Met 930 935 940 Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 945 950 955 960 Phe Glu Asp Arg Asp Gly Arg Gin Ile Gly Arg Ile Lys Asp Trp Thr 965 970 975 Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 980 985 990 Phe Thr Lys Asp Val Phe Ile Gin Tyr Phe Asn Asn Lys Asn Ala Ser 995 1000 1005 Leu Asp Pro Asn Ala Asn Glu His Ala Ile Lys Asn Lys Tyr Phe 1010 1015 1020 Gin Asn Gly Arg Ala Ile Ala Pro Met Pro Leu Arg Glu Phe Arg 1025 1030 1035 Ala Glu Ala Lys Lys His Leu Glu Asn Thr Leu Ile Ser Ile Lys 1040 1045 1050 Ala Lys Asn Lys Val Ile Thr Gly Asn Ile Asn Lys Thr Arg Lys 1055 1060 1065 Lys Gly Gly Val Asn Lys Asn Met Gin Gin Thr Pro Arg Gly Gin 1070 1075 1080 Leu His Leu Glu Thr Ile Tyr Gly Ser Gly Lys Gin Tyr Leu Thr 1085 1090 1095 Lys Glu Glu Lys Val Asn Ala Ser Phe Asp Met Arg Lys Ile Gly 1100 1105 1110 Thr Val Ser Lys Leu Ala Tyr Arg Asp Ala Leu Leu Lys Arg Leu 1115 1120 1125 Tyr Glu Asn Asp Asn Asp Pro Lys Lys Ala Phe Ala Gly Lys Asn 1130 1135 1140 Page 766 of 3790 Page 767 of 3790 156 1517 PRT Bacteroides sp. 156 Page 768 of 3790 Leu Arg Lys Lys Ala Leu Thr Gin Lys Ile Ser Lys Glu Glu Leu Ala 165 170 175 Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr Gin Leu Arg 180 185 190 Gly Glu Glu Glu Glu Thr Pro Asn Lys Leu Val Glu Tyr Tyr Ser Leu 195 200 205 Lys Val Glu Lys Val Glu Asp Ser Gly Glu Arg Lys Gly Lys Asp Thr 210 215 220 Trp Tyr Asn Val His Leu Glu Asn Gly Met Ile Tyr Arg Arg Thr Ser 225 230 235 240 Asn Ile Pro Leu Asp Trp Glu Gly Lys Thr Lys Glu Phe Ile Val Thr 245 250 255 Thr Asp Leu Glu Ala Asp Gly Ser Pro Lys Lys Asp Lys Glu Gly Asn 260 265 270 Ile Lys Arg Ser Phe Arg Ala Pro Lys Asp Asp Asp Trp Thr Leu Ile 275 280 285 Lys Lys Lys Thr Glu Ala Asp Ile Asp Lys Ile Lys Met Thr Val Gly 290 295 300 Ala Tyr Ile Tyr Asp Thr Leu Leu Gin Lys Pro Asp Gin Lys Ile Arg 305 310 315 320 Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr Lys Asn Glu Leu 325 330 335 Tyr Gin Ile Leu Lys Thr Gin Ser Glu Phe His Glu Glu Leu Arg Asp 340 345 350 Lys Gin Leu Tyr Ile Ala Cys Leu Asn Glu Leu Tyr Pro Asn Asn Glu 355 360 365 Pro Arg Arg Asn Ser Ile Ser Thr Arg Asp Phe Cys His Leu Phe Ile 370 375 380 Glu Asp Ile 385 Ile Phe Tyr Gin Arg Pro 390 Leu Lys 395 Ser Lys Lys Ser Leu 400 Ile Asp Asn Cys Pro Tyr Glu Glu Asn Arg Tyr Ile Asp Lys Glu Ser Page 771 of 3790 Page 772 of 3790 Gin Gly Leu Ser Ser Ala Pro Glu Asp Glu Asn Gly Asn Leu Pro 157 1399 PRT Olsenella uli 157 Met Asn Leu Arg Asn Thr Thr Asp Glu Tyr Asn Ile Gly Leu Asp Met 15 10 15 Gly Thr Asn Ser Val 20 Gly Trp Ala Val 25 Thr Asp Lys Ala Gly Ala 30 Ile Ala His Phe Lys 35 Gly Lys Pro Thr Leu Gly 40 Ser Arg Leu 45 Phe Asp Ala Ala Gin 50 Thr Ala Ala Gly Ala Arg 55 Ile His Arg Ser Gin Arg Arg Arg 60 Tyr Val Arg Arg Arg 65 Trp Arg Leu Asp 70 Leu Leu Gin 75 Ser Leu Phe Gin Asp Glu Val Ser Lys Val Asp Ser Glu Phe Phe Cys Arg Leu Arg Gin Page 774 of 3790 90 95 Ser Arg Leu Tyr Val Gly Asp Arg Glu Lys Gly His Ala Asp Tyr Thr 100 105 110 Trp Pro Ile Phe Asn Asp Ser Asp Phe Asn Glu Val Asp Tyr Tyr Lys 115 120 125 Arg Phe Pro Thr Ile Tyr His Leu Arg Lys Trp Leu Met Glu Thr Asp 130 135 140 Glu Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Thr His Asn Ile Val 145 150 155 160 Lys His Arg Gly Asn Phe Leu Arg Glu Asn Asn Lys Ser Leu Ser Ser 165 170 175 Arg Asp Ala Asn Pro Ala Gin Ala Val Lys Ser Leu Arg Leu Ala Leu 180 185 190 Asn Asp Trp Cys Ser Glu Arg Asp Tyr Glu Cys Ala Trp Lys Gly Glu 195 200 205 Glu Asp Asp Gly Ala Ile Asp Glu Ala Ile Leu Asn Val Leu Ala Asp 210 215 220 Gly Glu Lys Gly Arg Ser Asp Gin Ala Lys Glu Ile Ala Lys Leu Thr 225 230 235 240 Gly Val Asp Cys Gly Asp Ala Lys Gin Ser Lys Gin Cys Asn Glu Ala 245 250 255 Ile Ala Lys Ala Ile Val Gly Leu Lys Val Glu Met Lys Asn Ile Phe 260 265 270 Gly Glu Phe Pro Ala Glu Lys Thr Ser Tyr Ile Tyr Leu Ser Ser Asp 275 280 285 Glu Asp Val Glu Ala Val Arg Glu Ser Cys Pro Asp Asp Ser Gly Glu 290 295 300 Leu Phe Gin Ala Leu Cys Lys Leu Tyr Ser Ala Tyr Ile Leu Gin Glu 305 310 315 320 Leu Leu Ser Tyr Ala Asp Pro Ser Gly Gin Thr Ile Ser Ala Asn Met 325 330 335 Page 775 of 3790 Val Ala Lys Tyr Lys Gin Tyr Gly Arg Asp Leu Arg Leu Leu Lys Glu 340 345 350 Leu Thr Arg Thr Tyr Ala Pro Gin Lys Tyr Asp Leu Phe Phe Arg Gly 355 360 365 Glu Thr Tyr Ala Gly Ser Ser Asp Tyr Val Val Asp Glu Ala Arg Gly 370 375 380 Tyr Thr Arg Tyr Asn Leu Gly Thr Thr Lys Ala Asn Tyr Asp Asp Phe 385 390 395 400 Gin Lys Ser Val Lys Glu Leu Phe Lys Gly Thr Asp Ala Leu Gin Asp 405 410 415 Glu Arg Tyr Gin Glu Met Met Val Ala Phe Gly Glu Gin Lys Phe Leu 420 425 430 Arg Arg Leu Lys Thr Ser Asp Asn Gly Ser Ile Tyr Tyr Gin Leu His 435 440 445 Leu Glu Glu Leu His Thr Ile Leu Glu Asn Gin Gly Lys His Tyr Pro 450 455 460 Phe Leu Leu Ser Glu Glu Asp Lys Ile Glu Ser Leu Val Ser Phe Arg 465 470 475 480 Ile Pro Tyr Tyr Val Gly Pro Leu Thr Arg Lys Asn Ala Ala Ile Gly 485 490 495 His Asp Gly Lys Glu Arg Phe Ala Trp Ser Ser Arg Lys Asp Gly Met 500 505 510 Glu His Ala Val Ile Thr Pro Trp Asn Trp Glu Glu Ile Ile Asp Arg 515 520 525 Asp Lys Ser Ala Glu Asp Phe Ile Met Arg Met Thr Gly Asp Cys Thr 530 535 540 Tyr Leu Gin Gly Glu Pro Val Leu Pro Lys Cys Ser Leu Leu Tyr Glu 545 550 555 560 Glu Phe Cys Ala Leu Asn Glu 565 Phe Asn Gly Ala 570 His Trp Thr Val Asp 575 Gly Asp Asp Glu Arg Arg Phe Asp Ala Ala Gin Arg Glu Arg Ile Met 580 585 590 Page 776 of 3790 Cys Asp Leu Phe Arg Arg Thr Arg Ser Val Thr Tyr Asn Lys Val Ser 595 600 605 Asp Trp Leu Glu Arg Lys Tyr Asn Phe Thr Gly Ala Arg Val Arg Gly 610 615 620 Gly Gin Gly Glu His Gly Phe Glu Ser Lys Leu Gly Ser Tyr Ile Phe 625 630 635 640 Phe Cys Lys Asp Val Phe Lys Thr Asp Gly Leu Asp Glu Ala Asp Tyr 645 650 655 Thr Met Ile Glu Gin Ile Ile Leu Trp Ser Thr Leu Phe Glu Asp Arg 660 665 670 Asp Ile Leu Lys Arg Lys Ile Glu Glu Ala Tyr Gly Gly Asp Arg Leu 675 680 685 Thr Ser Glu Gin Ile Lys Val Ile Cys Lys Lys Arg Phe Thr Gly Trp 690 695 700 Gly Arg Leu Ser Lys Arg Leu Leu Thr Asp Ile Lys Val Asn Thr Asp 705 710 715 720 Thr Gly Arg Lys Ser Ile Met Asp Val Leu Arg Glu Gly Asn Pro Asn 725 730 735 Asn Gly Gin Arg Ser Arg Thr Met Val Phe Met Glu Val Leu Arg Asp 740 745 750 Glu Asp Leu Gly Phe Gin Lys Ala Ile Asp Gly Leu Asn Arg Asp Tyr 755 760 765 Phe Arg Glu His Asn Asn Gly Leu Met Asp Val Asn Asp Leu Pro Gly 770 775 780 Ser Pro Ala Ile Arg Arg Ser Ile Asn Gin Ala Val Arg Ile Val Asp 785 790 795 800 Glu Ile Ala Ser Ile Ala Arg Lys Glu Pro Thr Asn Ile Phe Ile Glu 805 810 815 Val Thr Arg Glu Glu Asp Asp Pro Arg Lys Lys Gly Lys Arg Thr Lys 820 825 830 Arg Arg Tyr Asp Ala Ile Lys Ser Ala Leu Glu Lys Phe Lys Lys Asp 835 840 845 Page 777 of 3790 Phe Ile Val Asn Ser Phe Leu Ser Ser Gly Phe Asp Glu Glu Thr Page 779 of 3790 Leu 158 1398 PRT Veillonella atypica 158 Met Glu Thr Gin Thr Ser Asn Gin Leu Ile Thr Ser His Leu Lys Asp 15 10 15 Tyr Pro Lys Gin Asp Tyr Phe Val Gly Leu Asp Ile Gly Thr Asn Ser 20 25 30 Val Gly Trp Ala Val Thr Asn Thr Ser Tyr Glu Leu Leu Lys Phe His 35 40 45 Ser His Lys Met Trp Gly Ser Arg Leu Phe Glu Glu Gly Glu Ser Ala 50 55 60 Val Thr Arg Arg Gly Phe Arg Ser Met Arg Arg Arg Leu Glu Arg Arg 65 70 75 80 Lys Leu Arg Leu Lys Leu Leu Glu Glu Leu Phe Ala Asp Ala Met Ala 85 90 95 Gin Val Asp Ser Thr Phe Phe Ile Arg Leu His Glu Ser Lys Tyr His 100 105 110 Tyr Glu Asp Lys Thr Thr Gly His Ser Ser Lys His Ile Leu Phe Ile 115 120 125 Page 781 of 3790 Tyr Val His Tyr Ile Lys Gin Gly Arg Thr Glu Glu Thr Ser Cys Ser 385 390 395 400 Arg Glu Asp Phe Tyr Lys Tyr Thr Lys Lys Ile Val Glu Gly Leu Ala 405 410 415 Asp Ser Lys Asp Lys Glu Tyr Ile Leu Asn Glu Ile Glu Leu Gin Thr 420 425 430 Leu Leu Pro Leu Gin Arg Ile Lys Asp Asn Gly Val Ile Pro Tyr Gin 435 440 445 Leu His Leu Glu Glu Leu Lys Val Ile Leu Asp Lys Cys Gly Pro Lys 450 455 460 Phe Pro Phe Leu His Thr Val Ser Asp Gly Phe Ser Val Thr Glu Lys 465 470 475 480 Leu Ile Lys Met Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 485 490 495 Asn Thr His His Asn Ile Asp Asn Gly Gly Phe Ser Trp Ala Val Arg 500 505 510 Lys Gin Ala Gly Arg Val Thr Pro Trp Asn Phe Glu Glu Lys Ile Asp 515 520 525 Arg Glu Lys Ser Ala Ala Ala Phe Ile Lys Asn Leu Thr Asn Lys Cys 530 535 540 Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 545 550 555 560 Ser Glu Phe Met Leu Leu Asn Glu Leu Asn Asn Val Arg Ile Asp Gly 565 570 575 Lys Ala Leu Ala Gin Gly Val Lys Gin His Leu Ile Asp Ser Ile Phe 580 585 590 Lys Gin Asp His Lys Lys Met Thr Lys Asn Arg Ile Glu Leu Phe Leu 595 600 605 Lys Asp Asn Asn Tyr Ile Thr Lys Lys His Lys Pro Glu Ile Thr Gly 610 615 620 Leu Asp Gly Glu Ile Lys Asn Asp Leu Thr Ser Tyr Arg Asp Met Val 625 630 635 640 Page 782 of 3790 Arg Ile Leu Gly Asn Asn Phe Asp Val Ser Met Ala Glu Asp Ile Ile 645 650 655 Thr Asp Ile Thr Ile Phe Gly Glu Ser Lys Lys Met Leu Arg Gin Thr 660 665 670 Leu Arg Asn Lys Phe Gly Ser Gin Leu Asn Asp Glu Thr Ile Lys Lys 675 680 685 Leu Ser Lys Leu Arg Tyr Arg Asp Trp Gly Arg Leu Ser Lys Lys Leu 690 695 700 Leu Lys Gly Ile Asp Gly Cys Asp Lys Ala Gly Asn Gly Ala Pro Lys 705 710 715 720 Thr Ile Ile Glu Leu Met Arg Asn Asp Ser Tyr Asn Leu Met Glu Ile 725 730 735 Leu Gly Asp Lys Phe Ser Phe Met Glu Cys Ile Glu Glu Glu Asn Ala 740 745 750 Lys Leu Ala Gin Gly Gin Val Val Asn Pro His Asp Ile Ile Asp Glu 755 760 765 Leu Ala Leu Ser Pro Ala Val Lys Arg Ala Val Trp Gin Ala Leu Arg 770 775 780 Ile Val Asp Glu Val Ala His Ile Lys Lys Ala Leu Pro Ser Arg Ile 785 790 795 800 Phe Val Glu Val Ala Arg Thr Asn Lys Ser Glu Lys Lys Lys Lys Asp 805 810 815 Ser Arg Gin Lys Arg Leu Ser Asp Leu Tyr Ser Ala Ile Lys Lys Asp 820 825 830 Asp Val Leu Gin Ser Gly Leu Gin Asp Lys Glu Phe Gly Ala Leu Lys 835 840 845 Ser Gly Leu Ala Asn Tyr Asp Asp Ala Ala Leu Arg Ser Lys Lys Leu 850 855 860 Tyr Leu Tyr Tyr Thr Gin Met Gly Arg Cys Ala Tyr Thr Gly Asn Ile 865 870 875 880 Ile Asp Leu Asn Gin Leu Asn Thr Asp Asn Tyr Asp Ile Asp His Ile Page 784 of 3790 Page 785 of 3790 Thr Ile Gly Val Lys Ile His Asn Leu Asp Glu Phe Lys Ile Ile 1370 1375 1380 Asn Glu Ser Ile Thr Gly Leu Tyr Ser Asn Glu Val Thr Ile Val Page 786 of 3790 Asn Cys Asn Tyr Leu Gly Asp Tyr Phe Tyr Lys Leu Tyr Thr Glu Lys 195 200 205 Gly Asn Thr Val Gin Ile Arg Lys Arg Tyr Thr Asp Arg Glu Lys His 210 215 220 Tyr Lys Asn Glu Phe Asn Ala Ile Cys Glu Lys Gin Glu Leu Asn Glu 225 230 235 240 Thr Ile Val Lys Glu Leu Asp Lys Ala Ile Phe Phe Gin Arg Lys Leu 245 250 255 Lys Pro Gin Arg His Gly Val Gly Lys Cys Thr Phe Glu Pro Asn Asn 260 265 270 Arg Arg Cys Ala Ile Ser His Pro Asp Phe Glu Arg Phe Arg Met Leu 275 280 285 Cys Phe Ile Asn Asn Ile Lys Ile Lys Thr Pro Phe Glu Glu Asn Leu 290 295 300 Arg Pro Leu Asn Asn Glu Glu Lys Ala Leu Ile Glu Pro Leu Phe Tyr 305 310 315 320 Arg Lys Ser Ile Lys Asn Phe Asp Phe Glu Glu Ile Ala Lys Lys Leu 325 330 335 Ala Gly Lys Asn Asn Tyr Cys Tyr Ile Lys Asp Asp Ser Ser Lys Gin 340 345 350 Tyr Lys Phe Asn Tyr Arg Met Ser Gin Gly Ala Ser Thr Cys Gin Thr 355 360 365 Ile Ala Lys Leu Lys Ser Ile Phe Gly Glu Glu Trp Lys Asn Gly Ile 370 375 380 Ala Glu Thr Tyr Thr Asn Arg Arg Lys Lys Glu Gly Leu Lys Lys Gin 385 390 395 400 Ala Glu Met Val Asp Asp Ile Trp Asn Val Leu Tyr Ser Val Ser Glu 405 410 415 Cys Asp Val Leu Lys Asp Phe Ala Ile Asn Lys Leu Gin Leu Asp Glu 420 425 430 Lys Thr Ala Asp Asn Phe Ser Lys Thr Lys Leu Ala Gin Gly Phe Ala 435 440 445 Page 787 of 3790 Thr Leu Ser Leu Lys Ala Ile Arg Lys Ile Leu Pro Phe Leu Glu Gin 450 455 460 Gly Phe Gly Tyr Thr Glu Ala Val Phe Leu Ala Asn Ile Pro Thr Val 465 470 475 480 Val Gly Lys Glu Tyr Trp Asn Asn Glu Asp Ile Arg Asn Asp Ile Met 485 490 495 Glu Glu Ile Lys Thr Ile Phe Tyr His Asn Thr Leu Lys Thr Asn Asp 500 505 510 Ser His Asn Thr Ile Leu Phe Cys Ile Lys Asp Ile Leu Ser Asn Asn 515 520 525 Phe Asp Leu Ala Pro Gly Ala Ile Asp Lys Leu Tyr His Pro Ser Met 530 535 540 Ile Asn Val Tyr Lys Asp Val Ile Pro Asn Glu Asp Gly Ile Leu Gin 545 550 555 560 Leu Gly Ser Pro Lys Ile Asp Ala Val Lys Asn Pro Met Ala Met Arg 565 570 575 Ser Leu His Ile Ile Arg Lys Val Val Asn Glu Leu Leu Arg Glu Gly 580 585 590 Ile Ile Asn Ser Asp Thr Glu Val Arg Ile Glu Tyr Ala Arg Glu Leu 595 600 605 Asn Asp Ala Asn Lys Arg His Ala Ile Ala Asp Trp Gin Lys Lys Gin 610 615 620 Tyr Gly Lys His Gin Lys Tyr Arg Lys Glu Ile Lys Glu Leu Phe Lys 625 630 635 640 Ala Glu Thr Gly Phe Glu Ile Glu Pro Asn Glu Thr Asp Ile Leu Lys 645 650 655 Phe Glu Leu Trp Glu Glu Gin Asn His Ile Cys Leu Tyr Thr Gly Gin 660 665 670 Glu Ile Gly Ile Ser Glu Phe Val Gly Glu Asn Pro Lys Tyr Asp Ile 675 680 685 Glu His Thr Ile Pro Arg Ser Leu Gly Gly Asp Ser Thr Lys Met Asn 160 1428 PRT Burkholderiales bacterium 160 Thr Glu Ala Glu Thr Asp Thr Ser Val Leu Glu Ser Leu Asp Pro Ser Page 789 of 3790 115 120 125 Val Phe Ser Ser Ala Pro Ser Phe Thr Asn Phe Phe Asn Asp Ser Glu 130 135 140 Pro Leu Asn Ile Gin Trp Glu Ala Ile Ala Asn Ser Pro Glu Thr Thr 145 150 155 160 Lys Ala Leu Asn Lys Glu Leu Ser Gly Gin Lys Glu Ala Asp Phe Lys 165 170 175 Lys Tyr Ile Lys Thr Ser Phe Pro Glu Tyr Ser Ala Lys Glu Ile Leu 180 185 190 Ala Asn Tyr Val Glu Gly Arg Arg Ala Ile Leu Asp Ala Ser Lys Tyr 195 200 205 Ile Ala Asn Leu Gin Ser Leu Gly His Lys His Arg Ser Lys Tyr Leu 210 215 220 Ser Asp Ile Leu Gin Asp Met Lys Arg Asp Ser Arg Ile Thr Arg Leu 225 230 235 240 Ser Glu Ala Phe Gly Ser Thr Asp Asn Leu Trp Arg Ile Ile Gly Asn 245 250 255 Ile Ser Asn Leu Gin Glu Arg Ala Val Arg Trp Tyr Phe Asn Asp Ala 260 265 270 Lys Phe Glu Gin Gly Gin Glu Gin Leu Asp Ala Val Lys Leu Lys Asn 275 280 285 Val Leu Val Arg Ala Leu Lys Tyr Leu Arg Ser Asp Asp Lys Glu Trp 290 295 300 Ser Ala Ser Gin Lys Gin Ile Ile Gin Ser Leu Glu Gin Ser Gly Asp 305 310 315 320 Val Leu Asp Val Leu Ala Gly Leu Asp Pro Asp Arg Thr Ile Pro Pro 325 330 335 Tyr Glu Asp Gin Asn Asn Arg Arg Pro Pro Glu Asp Gin Thr Leu Tyr 340 345 350 Leu Asn Pro Lys Ala Leu Ser Ser Glu Tyr Gly Glu Lys Trp Lys Ser 355 360 365 Page 790 of 3790 Trp Ala Asn Lys Phe Ala Gly Ala Tyr Pro Leu Leu Thr Glu Asp Leu 370 375 380 Thr Glu Ile Leu Lys Asn Thr Asp Arg Lys Ser Arg Ile Lys Ile Arg 385 390 395 400 Ser Asp Val Leu Pro Asp Ser Asp Tyr Arg Leu Ala Tyr Ile Leu Gin 405 410 415 Arg Ala Phe Asp Arg Ser Ile Ala Leu Asp Glu Cys Ser Ile Arg Arg 420 425 430 Thr Ala Glu Asp Phe Glu Asn Gly Val Val Ile Lys Asn Glu Lys Leu 435 440 445 Glu Asp Val Leu Ser Gly His Gin Leu Glu Glu Phe Leu Glu Phe Ala 450 455 460 Asn Arg Tyr Tyr Gin Glu Thr Ala Lys Ala Lys Asn Gly Leu Trp Phe 465 470 475 480 Pro Glu Asn Ala Leu Leu Glu Arg Ala Asp Leu His Pro Pro Met Lys 485 490 495 Asn Lys Ile Leu Asn Val Ile Val Gly Gin Ala Leu Gly Val Ser Pro 500 505 510 Ala Glu Gly Thr Asp Phe Ile Glu Glu Ile Trp Asn Ser Lys Val Lys 515 520 525 Gly Arg Ser Thr Val His Ser Ile Cys Asn Ala Ile Glu Asn Glu Arg 530 535 540 Lys Thr Tyr Gly Pro Tyr Phe Ser Glu Asp Tyr Lys Phe Val Lys Thr 545 550 555 560 Ala Leu Lys Glu Gly Lys Thr Glu Lys Glu Leu Ser Lys Lys Phe Ala 565 570 575 Ala Val Ile Lys Val Leu Lys Met Val Ser Glu Val Val Pro Phe Ile 580 585 590 Gly Lys Glu Leu Arg Leu Ser Asp Glu Ala Gin Ser Lys Phe Asp Asn 595 600 605 Pro Tyr Ser Leu Ala Gin Leu Tyr Asn Leu Ile Glu Thr Glu Arg Asn 610 615 620 Page 791 of 3790 Gly Phe Ser Lys Val Ser Leu Ala Ala His Leu Glu Asn Ala Trp Arg 625 630 635 640 Met Thr Met Thr Asp Gly Ser Ala Gin Cys Cys Arg Leu Pro Ala Asp 645 650 655 Cys Val Arg Pro Phe Asp Gly Phe Ile Arg Lys Ala Ile Asp Arg Asn 660 665 670 Ser Trp Glu Val Ala Lys Arg Ile Ala Glu Glu Val Lys Lys Ser Val 675 680 685 Asp Phe Thr Asn Gly Thr Val Lys Ile Pro Val Ala Ile Glu Ala Asn 690 695 700 Ser Phe Asn Phe Thr Ala Ser Leu Thr Asp Leu Lys Tyr Ile Gin Leu 705 710 715 720 Lys Glu Gin Lys Leu Lys Lys Lys Leu Glu Asp Ile Gin Arg Asn Glu 725 730 735 Glu Asn Gin Glu Lys Arg Trp Leu Ser Lys Glu Glu Arg Ile Arg Ala 740 745 750 Asp Ser His Gly Ile Cys Ala Tyr Thr Gly Arg Pro Leu Asp Asp Val 755 760 765 Gly Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Leu Lys Lys Ser 770 775 780 Glu Ser Ile Tyr Asn Ser Glu Val Asn Leu Ile Phe Val Ser Ala Gin 785 790 795 800 Gly Asn Gin Glu Lys Lys Asn Asn Ile Tyr Leu Leu Ser Asn Leu Ala 805 810 815 Lys Asn Tyr Leu Ala Ala Val Phe Gly Ala Ser Asp Leu Ser Gin Ile 820 825 830 Thr Asn Glu Ile Glu Ser Thr Val Leu Gin Leu Lys Ala Ala Gly Arg 835 840 845 Leu Gly Tyr Phe Asp Leu Leu Ser Glu Lys Glu Arg Ala Cys Ala Arg 850 855 860 His Ala Leu Phe Leu Asn Ser Asp Ser Glu Ala Arg Arg Ala Val Ile 865 870 875 880 Page 792 of 3790 Lys Ala Ala Lys Ile Leu Glu Ala Leu His Phe Val Thr Val Lys Page 794 of 3790 Ile Gly Ser Thr Ser Ile Gly Trp Ala Met Ile Arg Leu Ser Met Gin 20 25 30 Asn Glu Pro Ile Ala Ile Ile Arg Met Gly Val Arg Ile Phe Ser Asp 35 40 45 Gly Arg Asn Pro Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Val 50 55 60 Ala Arg Gin Met Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Thr 65 70 75 80 Arg Leu Leu Asn Ala Leu Val Gin Lys Lys Phe Phe Pro Glu Asp Ala 85 90 95 Asp Ala Arg Lys Ala Leu Val Val Leu Asn Pro Tyr Glu Leu Arg Lys 100 105 110 Glu Gly Leu Tyr Arg Gin Leu Ser Gly Pro Glu Phe Gly Arg Ala Leu 115 120 125 Phe His Ile Ser Gin Arg Arg Gly Phe Leu Ser Asn Arg Lys Thr Asp 130 135 140 Page 795 of 3790 Lys Lys Asp Asn Asp Ser Ser Val Leu Lys Lys Ala Ile Val Asp Leu 145 150 155 160 Arg Gin Gin Leu Glu Val Glu Asn Cys Gin Thr Ile Gly Glu Trp Leu 165 170 175 Phe Lys Gin Gin Gin Ser Gly Lys Ser Val Arg Ala Arg Leu Arg Gly 180 185 190 Lys Thr Gin Lys Asp Lys Ala Tyr Asp Phe Tyr Ile Asp Arg Ala Met 195 200 205 Ile Ala His Glu Phe Asp Thr Leu Trp Val Ser Gin Ala Lys Tyr Asp 210 215 220 Pro Leu Leu Phe Asn Glu Asp Ala Arg Ala Ile Leu Arg Asp Ile Leu 225 230 235 240 Leu Tyr Gin Arg Pro Leu Lys Pro Val Lys Pro Gly Arg Cys Thr Leu 245 250 255 Ile Pro Asp Glu Ser Arg Ala Pro Leu Ala Leu Pro Leu Thr Gin Gin 260 265 270 Ala Arg Ile Tyr Gin Glu Leu Asn His Leu Arg Ile Thr Thr Pro Ala 275 280 285 Leu Gly Ala Gin Ala Leu Thr Val Ala Gin Arg Asn Thr Ile Ala Ala 290 295 300 Leu Leu Glu Lys Ser Asp Val Thr Phe Val Lys Ile Ala Lys Ala Leu 305 310 315 320 Gly Leu Thr Ser Thr Thr Glu Phe Asn Leu Gin Asp Ile Lys Arg Asp 325 330 335 Arg Leu Lys Gly Asn Ala Thr Ala Ile Ile Leu Ala Arg Asn Gin Tyr 340 345 350 Phe Gly Arg Arg Trp His Asp Phe Asn Ala Asp Leu Gin Asn Leu Ile 355 360 365 Val Asp Lys Leu Val Asn Glu Gly Ser Glu Thr Ala Leu Ile Glu Trp 370 375 380 Leu Lys Ala Asn Thr Asp Val Asp Glu Ser Ala Ala Glu Arg Val Ser 385 390 395 400 Page 796 of 3790 Gly Val Thr Leu Pro Glu Gly Tyr Gly Ser Leu Ser Val Ala Ala Leu 405 410 415 Arg Arg Leu Leu Pro Ala Leu Lys Glu Asp Val Val Val Tyr Ser Glu 420 425 430 Ala Val Lys Arg Ala Gly Phe Asp Ser His Ser Ala Leu Ser Leu Ile 435 440 445 Glu Gin Thr Gly Glu Leu Tyr Gin Glu Leu Pro Tyr Tyr Gly Glu Val 450 455 460 Leu Gin Arg His Val Gly Phe Gly Ser Gly Asp Pro Asn Asp Ser Pro 465 470 475 480 Glu Arg Arg Phe Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu 485 490 495 Asn Glu Leu Arg Lys Ile Ile Asn Ala Leu Ile Lys Arg Tyr Gly Asn 500 505 510 Pro Ala Glu Val Val Val Glu Leu Ala Arg Asp Leu Lys Leu Ser Arg 515 520 525 Glu Lys Arg Lys Glu Ile Gin Glu Glu Gin Lys Gin Arg Gin Asp Arg 530 535 540 Asn Glu Lys Arg Ile Lys Asp Ala Cys Glu Ile Leu Gly Ile Asp Pro 545 550 555 560 Leu Val Ile Asp Arg Gly Lys Arg Arg Glu Ile Ser Gin Lys Met Gin 565 570 575 Leu Trp Asp Glu Leu Asn Pro Lys Asp Ala Ala Asn Arg Arg Cys Pro 580 585 590 Tyr Thr Gly Asp Gin 595 Ile Ser Ile Glu Lys Leu Leu 600 Ser Ala Glu Val 605 Glu Ile Glu His 610 Ile Leu Pro Phe 615 Ser Lys Thr Leu Asp Asp 620 Ser Leu Asn Asn Lys 625 Thr Val Ala Met 630 Arg Arg Ala Asn 635 Arg Asp Lys Gly Asn 640 Arg Thr Pro Tyr Glu Ala Phe Gly Glu Ser Leu Asn Pro Asp Tyr Asp 645 650 655 Page 797 of 3790 Tyr Asp Ala Ile Leu Gin Arg Ala Ser Leu Met Pro Arg Glu Lys Arg 660 665 670 Lys Arg Phe Ala Ser Asp Gly Tyr Gin Gin Trp Leu Arg Asp Asp Lys 675 680 685 Asp Phe Leu Ser Arg Ala Leu Asn Asp Thr Ala Tyr Leu Ser Arg Ile 690 695 700 Ala Lys Glu Tyr Leu Thr Leu Ile Cys Pro Pro Asn Ser Val Arg Ala 705 710 715 720 Ile Pro Gly Arg Met Thr Ala Gin Leu Arg Ala Met Phe Gly Leu Asn 725 730 735 Arg Leu Leu Ser Glu Gly Gly Ile Lys Asn Arg Glu Asp His Arg His 740 745 750 His Ala Ile Asp Ala Ala Val Ile Gly Val Thr Asp Gin Gly Leu Leu 755 760 765 Gin Lys Phe Ser Arg Ala Ser Ala Arg Thr Arg Glu Leu Gin Leu Ser 770 775 780 Arg Leu Val Asp Asp Met Pro Leu Pro Trp Asp Thr Tyr Arg Glu His 785 790 795 800 Val Thr Arg Ala Leu Glu His Leu Val Val Ser His Lys Pro Asp His 805 810 815 Gly Tyr Gin Gly Lys Met His Glu Asp Thr Ala Trp Gly Leu Arg Asp 820 825 830 Asn Gly Gin Val Thr Arg Arg Val Arg Ser Glu Asp Gly Gly Pro Arg 835 840 845 Gin Arg Leu Leu Glu Asn Lys Asn Val Val Lys Ile Asn Ser Thr Arg 850 855 860 Asp Phe Ser Arg His Gly Ile Asp Glu Gin Gly Gin Val Asn Ala Tyr 865 870 875 880 Lys Gly Tyr Val Gly Gly Ser Asn Tyr Cys Ile Glu Ile Trp Ile Asp 885 890 895 Glu Lys Gly Lys Trp Asn Ser Asp Val Val Ser Thr Phe Gin Ala Tyr 900 910 Page 798 of 3790 905 His Met Ala Ile Ser Pro Ile Gly Asp Ala Arg Pro Val Arg Tyr Glu Val Asp Pro Thr Phe Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser Page 800 of 3790 Leu Lys Lys Val Ile Glu Asn His Pro Asp Ala Lys Lys Ala Lys Ala 340 345 350 Leu Lys Glu Thr Tyr Thr Ala Tyr Val Gly Lys Thr Asp Asp Lys Thr 355 360 365 Gin Asn Gin Asp Asp Phe Tyr Lys Ala Val Glu Lys Asn Leu Asp Asp 370 375 380 Ser Pro Asp Ala Lys Glu Ile Lys Arg Leu Ile Gin Leu Asp Gin Phe 385 390 395 400 Met Pro Lys Gin Arg Thr Gly Gin Asn Gly Ala Ile Pro His Gin Leu 405 410 415 His Gin Gin Glu Leu Asp Gin Ile Ile Glu Lys Gin Ser Lys Tyr Tyr 420 425 430 Pro Phe Leu Ala Glu Pro Asn Pro Asn Val Lys Arg Arg Lys Asp Ala 435 440 445 Pro Tyr Lys Leu Asp Glu Leu Ile Ala Phe Lys Ile Pro Tyr Tyr Val 450 455 460 Gly Pro Leu Val Thr Pro Glu Glu Gin Ala Gin Asn Gly Glu Asn Val 465 470 475 480 Phe Ala Trp Met Lys Arg Lys Ala Ala Gly Pro Ile Thr Pro Trp Asn 485 490 495 Phe Asp Glu Lys Val Asp Arg Met Glu Ser Ala Asn Arg Phe Ile Arg 500 505 510 Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe Gly Glu Asp Val Leu Pro 515 520 525 Ala Glu Ser Met Ile Tyr Gin Lys Phe Val Val Leu Asn Glu Leu Asn 530 535 540 Asn Leu Lys Ile Asn Gly Arg His Leu Ser Leu Lys Asp Lys Gin Asp 545 550 555 560 Val Tyr Asn Asp Leu Phe Lys Gin Gin Lys Thr Val Ser Ile Lys Ala 565 570 575 Leu Gin Asn Tyr Tyr Val Thr Lys Lys Lys Ala Ala Thr Ala Pro Thr 580 585 590 Page 801 of 3790 Val Gly Gly Leu Ala Asp Pro Lys Lys Phe Leu Ser Ser Leu Ser Thr 595 600 605 Tyr Ile Asp Phe Lys Asn Met Phe Gly Glu Arg Val Asn Asp Pro Gin 610 615 620 Phe Gin Glu Asp Leu Glu Gin Ile Val Glu Trp Ser Thr Ile Phe Glu 625 630 635 640 Asp Arg Gly Ile Phe Lys Ala Lys Leu Gin Ala Leu Gly Trp Leu Ser 645 650 655 Glu Lys Gin Ile Gin Gin Leu Val Ala Lys Arg Tyr Lys Gly Trp Gly 660 665 670 Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Lys Asn Ala Glu Gly Tyr 675 680 685 Ser Ile Leu Asp Glu Met Trp Arg Ser Thr Gly Asn Phe Met Gin Ile 690 695 700 Gin Ser Arg Pro Glu Phe Ala Ala Leu Ile Gin Gin Ala Asn Glu Lys 705 710 715 720 Gin Phe Glu Gly Asn Asp Pro Asp Asn Val Trp Glu Asn Ile Glu Asn 725 730 735 Ile Leu Gly Asp Ala Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg 740 745 750 Gin Val Val Lys Val Val Gin Asp Ile Glu Lys Ala Val Gly Asn Pro 755 760 765 Pro Glu Lys Ile Ala Ile Glu Phe Thr Arg Glu Ala Ala Ala Asn Pro 770 775 780 Gin Arg Thr Gin Ser Arg Leu Arg Thr Leu Glu Lys Leu Tyr Glu Ser 785 790 795 800 Ala Glu Glu Val Val Asp Ala Gly Leu Thr Ala Glu Leu Ala Glu Phe 805 810 815 Lys Glu Asn Lys His Val Leu Ser Asp Lys Tyr Tyr Leu Tyr Phe Thr 820 825 830 Gin Leu Gly Arg Asp Val Tyr Thr Gly Asp Thr Ile Ser Leu Asp Lys 835 840 845 Page 802 of 3790 Arg Arg Ala Glu Leu Phe Asn Gin Thr Val Tyr Pro Lys Asn Tyr 163 1364 PRT Peptoniphilus duerdenii 163 Met Lys Asn Leu Lys Glu Tyr Tyr Ile Gly Leu Asp Ile Gly Thr Ala 15 10 15 Ser Val Gly Trp Ala Val Thr Asp Glu Ser Tyr Asn Ile Pro Lys Phe 20 25 30 Asn Gly Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr 35 40 45 Ala Glu Glu Arg Arg Thr Gin Arg Gly Ser Arg Arg Arg Leu Asn Arg 50 55 60 Arg Lys Glu Arg Ile Asn Leu Leu Gin Asp Leu Phe Ala Thr Glu Ile 65 70 75 80 Ser Lys Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu 85 90 95 Tyr Arg Glu Asp Lys Asp Glu Lys Leu Lys Ser Lys Tyr Thr Leu Phe 100 105 110 Asn Asp Lys Asp Phe Lys Asp Arg Asp Tyr His Lys Lys Tyr Pro Thr 115 120 125 Ile His His Leu Ile Met Asp Leu Ile Glu Asp Glu Gly Lys Lys Asp 130 135 140 Ile Arg Leu Leu Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly 145 150 155 160 His Phe Ile Phe Glu Gly Gin Lys Phe Asp Thr Lys Asn Ser Phe Asp 165 170 175 Page 805 of 3790 Lys Ser Ile Asn Asp Leu Lys Ile His Leu Arg Asp Glu Tyr Asn Ile 180 185 190 Asp Leu Glu Phe Asn Asn Glu Asp Leu Ile Glu Ile Ile Thr Asp Thr 195 200 205 Thr Leu Asn Lys Thr Asn Lys Lys Lys Glu Leu Lys Asn Ile Val Gly 210 215 220 Asp Thr Lys Phe Leu Lys Ala Ile Ser Ala Ile Met Ile Gly Ser Ser 225 230 235 240 Gin Lys Leu Val Asp Leu Phe Glu Asp Gly Glu Phe Glu Glu Thr Thr 245 250 255 Val Lys Ser Val Asp Phe Ser Thr Thr Ala Phe Asp Asp Lys Tyr Ser 260 265 270 Glu Tyr Glu Glu Ala Leu Gly Asp Thr Ile Ser Leu Leu Asn Ile Leu 275 280 285 Lys Ser Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Asp Ala 290 295 300 Asp Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Lys Ala Phe Val Lys 305 310 315 320 Lys Phe Asn Lys His Gly Lys Asp Leu Lys Thr Leu Lys Arg Ile Ile 325 330 335 Lys Lys Tyr Leu Pro Ser Glu Tyr Ala Asn Ile Phe Arg Asn Lys Ser 340 345 350 Ile Asn Asp Asn Tyr Val Ala Tyr Thr Lys Ser Asn Ile Thr Ser Asn 355 360 365 Lys Arg Thr Lys Ala Ser Lys Phe Thr Lys Gin Glu Asp Phe Tyr Lys 370 375 380 Phe Ile Lys Lys His Leu Asp Thr Ile Lys Glu Thr Lys Leu Asn Ser 385 390 395 400 Ser Glu Asn Glu Asp Leu Lys Leu Ile Asp Glu Met Leu Thr Asp Ile 405 410 415 Glu Phe Lys Thr Phe Ile Pro Lys Leu Lys Ser Ser Asp Asn Gly Val 420 425 430 Page 806 of 3790 Ile Pro Tyr Gin Leu Lys Leu Met Glu Leu Lys Lys Ile Leu Asp Asn 435 440 445 Gin Ser Lys Tyr Tyr Asp Phe Leu Asn Glu Ser Asp Glu Tyr Gly Thr 450 455 460 Val Lys Asp Lys Val Glu Ser Ile Met Glu Phe Arg Ile Pro Tyr Tyr 465 470 475 480 Val Gly Pro Leu Asn Pro Asp Ser Lys Tyr Ala Trp Ile Lys Arg Glu 485 490 495 Asn Thr Lys Ile Thr Pro Trp Asn Phe Lys Asp Ile Val Asp Leu Asp 500 505 510 Ser Ser Arg Glu Glu Phe Ile Asp Arg Leu Ile Gly Arg Cys Thr Tyr 515 520 525 Leu Lys Glu Glu Lys Val Leu Pro Lys Ala Ser Leu Ile Tyr Asn Glu 530 535 540 Phe Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn Glu Phe Leu 545 550 555 560 Ile Thr Glu Glu Met Lys Lys Ala Ile Phe Glu Glu Leu Phe Lys Thr 565 570 575 Lys Lys Lys Val Thr Leu Lys Ala Val Ser Asn Leu Leu Lys Lys Glu 580 585 590 Phe Asn Leu Thr Gly Asp Ile Leu Leu Ser Gly Thr Asp Gly Asp Phe 595 600 605 Lys Gin Gly Leu Asn Ser Tyr Ile Asp Phe Lys Asn Ile Ile Gly Asp 610 615 620 Lys Val Asp Arg Asp Asp Tyr Arg Ile Lys Ile Glu Glu Ile Ile Lys 625 630 635 640 Leu Ile Val Leu Tyr Glu Asp Asp Lys Thr Tyr Leu Lys Lys Lys Ile 645 650 655 Lys Ser Ala Tyr Lys Asn Asp Phe Thr Asp Asp Glu Ile Lys Lys Ile 660 665 670 Ala Ala Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys Arg Phe Leu 675 680 685 Page 807 of 3790 Thr Gly Ile Glu Gly Val Asp Lys Thr Thr Gly Glu Lys Gly Ser Ile 690 695 700 Ile Tyr Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu Leu Met Ser 705 710 715 720 Gly His Tyr Thr Phe Thr Glu Glu Val Glu Lys Leu Asn Pro Val Glu 725 730 735 Asn Arg Glu Leu Cys Tyr Glu Met Val Asp Glu Leu Tyr Leu Ser Pro 740 745 750 Ser Val Lys Arg Met Leu Trp Gin Ser Leu Arg Val Val Asp Glu Ile 755 760 765 Lys Arg Ile Ile Gly Lys Asp Pro Lys Lys Ile Phe Ile Glu Met Ala 770 775 780 Arg Ala Lys Glu Ala Lys Asn Ser Arg Lys Glu Ser Arg Lys Asn Lys 785 790 795 800 Leu Leu Glu Phe Tyr Lys Phe Gly Lys Lys Ala Phe Ile Asn Glu Ile 805 810 815 Gly Glu Glu Arg Tyr Asn Tyr Leu Leu Asn Glu Ile Asn Ser Glu Glu 820 825 830 Glu Ser Lys Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gin Leu 835 840 845 Gly Arg Cys Met Tyr Ser Leu Glu Pro Ile Asp Leu Ala Asp Leu Lys 850 855 860 Ser Asn Asn Ile Tyr Asp Gin Asp His Ile Tyr Pro Lys Ser Lys Ile 865 870 875 880 Tyr Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Asn Leu Asn 885 890 895 His Glu Lys Gly Asn Gin Tyr Pro Ile Pro Glu Lys Val Leu Asn Lys 900 905 910 Asn Ala Tyr Gly Phe Trp Lys Ile Leu Phe Asp Lys Gly Leu Ile Gly 915 920 925 Gin Lys Lys Tyr Thr Arg Leu Thr Arg Arg Thr Pro Phe Glu Glu Arg 930 935 Page 808 of 3790 940 164 1089 PRT Corynebacterium matruchotii 164 Met Asn Ser Ala Asn Val Asn Tyr Arg Val Gly Ile Asp Val Gly Ser 15 10 15 Page 811 of 3790 Arg Ile Ala Ala Leu Ile Gly Asn Leu Arg Ile Arg Gly Gly Lys Gly 275 280 285 Asn Arg Arg Leu Thr Thr Glu Glu Thr Arg Leu Val Phe Asp Tyr Leu 290 295 300 Arg Ser Leu Pro Ala Lys Gin Glu Pro Thr Trp Gin Leu Val Ala Glu 305 310 315 320 Gin Leu Lys Ile Asp Arg Gly Asn Leu Val Gly Thr Ala Ile Met Thr 325 330 335 Asp Asp Gly Glu Arg Ala Gly Ala Lys Pro Pro Val His Asp Thr Asn 340 345 350 Arg Ile Met Glu Asn Thr Lys Ile Lys Pro Leu Ala Thr Trp Trp Lys 355 360 365 Ser Ala Asp Ala Asp Ala Arg Ala Ala Met Val Lys Ala Leu Ser Asn 370 375 380 Ala Glu Val Asp Asp Phe Asp Ser Gin Ala Gly Ala Gin Val Gin Glu 385 390 395 400 Phe Phe Phe Gly Ile Ser Asp Glu Asp Gin Glu Lys Leu Asp Gly Leu 405 410 415 His Leu Pro Ile Gly Arg Ala Ala Tyr Ser Glu Asp Thr Leu Asp Arg 420 425 430 Leu Thr Lys Arg Met Ile Gly Glu Gly Met Asp Leu Tyr Glu Ala Arg 435 440 445 Gin Ala Glu Phe Lys Ile Ser Asn Asp Trp Ala Pro Pro Ala Pro Glu 450 455 460 Ile Gly Glu Arg Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala 465 470 475 480 Thr Ala Arg Trp Leu Asn Ala Ala Glu Arg Gin Trp Gly Ala Pro Lys 485 490 495 Ser Val Asn Ile Glu His Val Arg Ala Ala Phe Met Ser Glu Ser Ser 500 505 510 Ala Arg Glu Leu Asp Arg Asp Asn Gin Gin Arg Ala Lys Arg Asn Val 515 520 525 Page 812 of 3790 Lys Val Val Ala Glu Met Gin Glu Lys Leu Gly Ile Glu Gly Arg Pro 530 535 540 Ser Arg Ala Asp Val Trp Arg Phe Gin Ser Ile Gin Arg Gin Asn Gly 545 550 555 560 Lys Cys Ala Tyr Cys Gly Ala Glu Ile Ser Phe Lys Asn Ser Glu Met 565 570 575 Asp His Ile Ile Pro Gin Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp 580 585 590 Asn Leu Val Ala Val Cys Arg Glu Cys Asn Ser Ser Lys Ser Asn Ile 595 600 605 Ala Phe Ala Val Trp Ala Glu Asn Thr Ser Arg Pro Gly Val Ser Val 610 615 620 Gin Lys Ala Ile Glu Arg Thr His His Trp Val Thr Asp Ser Gly Leu 625 630 635 640 Arg Lys Pro Glu Phe Asp Lys Phe Arg Lys Gin Val Cys Asp Arg Leu 645 650 655 Arg Arg Lys Ala Thr Asp Glu Pro Ile Asp Ala Arg Ser Leu Glu Ser 660 665 670 Val Ala Trp Met Ala Asn Glu Leu Arg Ser Arg Ile Ala Gin Lys Phe 675 680 685 Lys Asp Gly Asp Thr Lys Val Arg Val Tyr Lys Gly Ala Leu Thr Ala 690 695 700 Glu Ala Arg Arg Ala Ser Gly Ile Ser Gly Lys Leu Glu Phe Val Asp 705 710 715 720 Gly Lys Gly Lys Ser Arg Leu Asp Arg Arg His His Ala Val Asp Ala 725 730 735 Ala Val Val Ala Phe Thr Ser Asn Tyr Val Ala Glu Thr Leu Ala Leu 740 745 750 Arg Ser Asn Met Lys 755 Phe Asp Gin 760 Glu Leu Arg Arg Lys 765 Ala Pro Gin Trp Arg Glu Phe Thr Gly Ser Asp His Val His Gin Val Glu Trp Thr Asp Thr Pro Gly 995 Ile Val Lys Leu Arg Glu Glu Tyr Gly Pro Val Asn 1000 1005 Arg Trp 1010 Arg Leu Ala Gly Leu 1015 Thr Ser Val Thr Arg 1020 Leu Asn Leu Page 814 of 3790 1085 165 1134 PRT Streptococcus mitis 165 Page 816 of 3790 Ser Gin Asp Gin Val Leu Glu Leu Val Gin Phe Arg Lys Asn Asn Ser 405 410 415 Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr Ile 435 440 445 Leu Thr Arg Leu Gly Lys Gin Lys Ser Lys Glu Thr Ser Lys Arg Thr 450 455 460 Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 465 470 475 480 Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Ile Asn Glu Ala Thr 485 490 495 Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 500 505 510 Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gin Lys Ala 515 520 525 Asn Gin Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gin Tyr 530 535 540 Asn Gly Lys Lys Glu Leu Pro Asp Asn Ile Phe His Gly His Lys Glu 545 550 555 560 Leu Ala Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Lys Cys Leu 565 570 575 Tyr Thr Gly Lys Thr Ile Pro Ile Ser Asp Leu Ile Tyr Asn Gin Tyr 580 585 590 Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 595 600 605 Ser Leu Ser Asn Lys Val Leu Ala Leu Ala Thr Ala Asn Gin Glu Lys 610 615 620 Gly Gin Arg Thr Pro Phe Gin Ala Leu Asp Ser Met Asp Asp Ala Trp 625 630 635 640 Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Leu Lys Ser Leu Ser 645 650 655 Page 817 of 3790 Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 660 665 670 Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 675 680 685 Ser Ser Arg Val Val Leu Asn Ala Leu Gin Asp Phe Tyr Lys Ser His 690 695 700 Gin Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gin Phe Thr Ser Gin 705 710 715 720 Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 725 730 735 His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg Leu 740 745 750 Trp Lys Lys Gin Asn Asn Pro Leu Ile Thr Tyr Lys Glu Gly Gin Phe 755 760 765 Val Asp Ser Gin Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 770 775 780 Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 785 790 795 800 Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp 805 810 815 Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 820 825 830 Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 835 840 845 Lys Ile Lys Asp Ile Tyr Ser Leu Gly Thr Lys Thr Pro Ser Lys Thr 850 855 860 Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Asn Lys Asp Lys Ser Gin Phe 865 870 875 880 Leu Met Phe Gin Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 885 890 895 Ile Met Glu Gin Tyr Arg Pro Phe Lys Glu Tyr Asp Lys Thr Gly Lys 900 910 Page 818 of 3790 905 Lys Pro Lys Leu Lys Phe 1130 Page 819 of 3790 Page 821 of 3790 Phe Asp Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr 485 490 495 Arg Met Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro 500 505 510 Lys His Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr 515 520 525 Lys Ile Lys Tyr Val Asn Glu Gin Gly Lys Asp Ser Phe Phe Asp Ser 530 535 540 Asn Met Lys Gin Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys 545 550 555 560 Val Thr Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu 565 570 575 Tyr Arg Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe 580 585 590 Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys 595 600 605 Ala Phe Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile 610 615 620 Lys Thr Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu 625 630 635 640 Gin Lys Tyr Ser Asp Ile Phe Thr Ala Asp Gin Leu Lys Lys Leu Glu 645 650 655 Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn 660 665 670 Gly Ile Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile 675 680 685 Asp Asp Gly Ser Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp 690 695 700 Thr Leu Pro Phe Lys Gin Ile Ile Gin Lys Ser Gin Val Val Gly Asp 705 710 715 720 Val Asp Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala 725 730 735 Page 822 of 3790 Ile Lys Lys Gly Ile Leu Gin Ser Val Lys Ile Val Asp Glu Leu Val 740 745 750 Lys Val Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg 755 760 765 Glu Asn Gin Thr Thr Asn Arg Gly Arg Ser Gin Ser Gin Gin Arg Leu 770 775 780 Lys Lys Leu Gin Asn Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn 785 790 795 800 Glu Glu Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu 805 810 815 Gin Asn Asp Gin Leu Phe Leu Tyr Tyr Ile Gin Asn Gly Lys Asp Met 820 825 830 Tyr Thr Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile 835 840 845 Asp His Ile Ile Pro Gin Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn 850 855 860 Arg Val Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val 865 870 875 880 Pro Ser Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu 885 890 895 Tyr Lys Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys 900 905 910 Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys 915 920 925 Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys His Val Ala Gin Ile 930 935 940 Leu Asp Ala Arg Phe Asn Thr Glu Ser Asp Glu Asn Asp Lys Val Ile 945 950 955 960 Arg Asp Val Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gin Phe 965 970 975 Arg Lys Asp Phe Glu Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His 980 990 Page 823 of 3790 985 His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Leu 995 1000 1005 Page 824 of 3790 1370 167 1099 PRT Corynebacterium accolens 167 Met Ser Leu Leu Tyr Arg Val Gly Ile Asp Val Gly Thr Tyr Ser Leu 15 10 15 Gly Cys Thr Ala Ile Glu Val Asp Asp Asn Asp Gin Pro Val Ser Ile 20 25 30 Leu Ser Ser Val Ser Leu Ile His Asp Ser Gly Leu Asp Pro Asp Gin 35 40 45 Page 826 of 3790 Arg Asp Glu Lys Leu Ile Val Phe Asn Tyr Leu Val Asn Leu Pro Lys 305 310 315 320 Lys Glu Glu Pro Ser Trp Leu Lys Ile Ala Glu Ile Leu Asn Ile Asp 325 330 335 Arg Gly Gin Leu Arg Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 340 345 350 Ala Gly Ala Thr Pro Pro Val His Asp Thr Asn Arg Thr Ile Leu Asp 355 360 365 Ser Lys Val Lys Pro Leu Ala His Trp Trp Glu Asn Ala Ser Asp Asp 370 375 380 Glu Arg Ala Ala Met Leu Lys Ser Leu Ser Asn Ser Glu Val Glu Asp 385 390 395 400 Phe Asp Ser Pro Ala Gly Ala Gin Val Gin Ala Phe Phe Ala Asp Leu 405 410 415 Asp Glu Thr Glu Gin Glu Lys Leu Asp Ser Leu His Leu Pro Met Gly 420 425 430 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Met Arg Leu Thr Asn Arg Met 435 440 445 Leu Asp Glu Asn Leu Asp Leu Tyr Glu Ala Arg Leu Ala Glu Phe Gly 450 455 460 Ile Pro Lys Asp Trp Ala Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 465 470 475 480 Gly Asn Pro Ala Val Asp Arg Val Leu Lys Gly Val Ala Arg Trp Leu 485 490 495 Glu Ala Ala Ala Asp Glu Trp Gly Ala Pro Lys Ser Val Val Ile Glu 500 505 510 His Val Arg Asp Gly Phe Val Ser Lys Ser Lys Ala Ile Glu Ile Asp 515 520 525 Arg Ala Asn Asn Asn Arg His Lys Arg Asn Arg Glu Leu Phe Gin Lys 530 535 540 Met Gin Glu Asn Leu Gly Ile Glu Gly Lys Val Arg Ser Ser Asp Leu 545 550 555 560 Page 827 of 3790 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 565 570 575 Gly Ser Pro Ile Thr Tyr Thr Thr Cys Glu Met Asp His Ile Val Pro 580 585 590 Arg Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala Thr 595 600 605 Cys His Arg Cys Asn Leu Ala Lys Lys Asn Ile Pro Phe Ala Val Trp 610 615 620 Ala Glu Lys Ser Thr Ile Pro Gly Val Ser Val Lys Glu Ala Leu Asp 625 630 635 640 Arg Thr Arg His Trp Ser Glu Asp Ser Gly Met Ser Lys Lys Asp Phe 645 650 655 Gin Lys Phe Arg Lys Asn Val Cys Glu Arg Leu Asn Arg Thr Val Val 660 665 670 Asp Glu Pro Leu Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 675 680 685 Asn Glu Leu Arg Gly Arg Val Ala Gin Arg Phe Gin Glu Glu Asn Thr 690 695 700 Thr Val Asn Val Tyr Arg Gly Ala Leu Thr Ala Glu Ala Arg Arg Ala 705 710 715 720 Ala Gly Ile Thr Asp Lys Leu Arg Phe Ile Asp Gly Thr Gly Lys Ser 725 730 735 Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala Phe 740 745 750 Ile His Asn Tyr Val Ala Glu Thr Leu Ala Ile Arg Ser Asn Lys Lys 755 760 765 Arg Glu Ala Gin Leu Leu Gin Gly Thr Ser Gin Trp Lys Glu Phe Thr 770 775 780 Gly Ser Asp Asp Lys His Arg Ala Val Trp Asn Ala Trp Ile Pro Lys 785 790 795 800 Met Gin Lys Leu Ala Val Leu Leu Gin Ile Ala Leu Asp Glu Asp Arg 805 815 Page 828 of 3790 810 Glu 168 1054 PRT Actinobacillus pleuropneumoniae 168 Met Lys Leu Thr Pro Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 15 10 15 Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Gin Glu Asn Pro 20 25 30 Leu Gly Leu Ile Asp Val Gly Val Arg Thr Phe Asp Arg Ala Glu Val 35 40 45 Ala Lys Thr Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser 50 55 60 Ser Arg Arg Leu Val Lys Arg Arg Ala Asp Arg Ile Lys Lys Val Lys 65 70 75 80 Arg Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Ala Asp Glu Gin Leu 85 90 95 Pro Asn Asp Val Trp Gin Leu Arg Val Lys Gly Leu Asp Gin Lys Leu 100 105 110 Glu Arg Gin Glu Trp Ala Ala Val Leu Leu His Leu Leu Lys His Arg 115 120 125 Gly Tyr Leu Ser Gin Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 130 135 140 Leu Gly Ala Leu Arg Ser Gly Val Ala Ala Asn His Gin Ile Leu Gin 145 150 155 160 Page 830 of 3790 Ser Ala Glu Tyr Arg Thr Pro Ala Glu Ile Ala Val Lys Lys Phe His 165 170 175 Val Glu Glu Gly His Ile Arg Asn Gin Arg Gly Ala Tyr Thr His Thr 180 185 190 Phe Ser Arg Leu Asp Leu Leu Ala Glu Ile Glu Leu Leu Phe Thr Arg 195 200 205 Gin Thr Glu Leu Gly Asn Pro His Thr Ser Ala Lys Leu Leu Glu Asn 210 215 220 Leu Thr Ala Leu Leu Met Trp Gin Lys Pro Ala Leu Ala Gly Glu Ala 225 230 235 240 Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys 245 250 255 Ala Ala Lys Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys 260 265 270 Leu Asn Asn Leu Arg Ile Leu Glu Gin Gly Ala Glu Arg Ala Leu Thr 275 280 285 Asp Asn Glu Arg Phe Ala Leu Leu Asp Gin Pro Tyr Glu Lys Ala Lys 290 295 300 Phe Thr Tyr Ala Gin Ala Arg Thr Met Leu Ala Leu Pro Asp Glu Ala 305 310 315 320 Ile Phe Lys Gly Val Arg 325 Tyr Gin Gly Glu Asp 330 Lys Lys Ala Val 335 Glu Thr Lys Thr Ile Leu Met 340 Glu Met Lys Ala Tyr His 345 Gin Ile Arg Lys 350 Ala Leu Glu Asn Ala Asp 355 Leu Lys 360 Ala Glu Trp Asn Glu Leu Lys 365 Asn Asn Ser Glu Leu 370 Leu Asp Asp 375 Ile Gly Thr Ala Phe 380 Ser Leu His Lys Thr Asp Glu Asp 385 Ile Cys Arg Tyr Leu Asp Gly Lys Leu Ser Glu 390 395 Ser 400 Ile Leu Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gin 405 410 415 Page 831 of 3790 Leu Ser Leu Lys Ala Leu Gin Gin Ile Leu Pro Leu Met Leu Gin Gly 420 425 430 Gin Arg Tyr Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly 435 440 445 Lys Lys Ser Ala Glu Ile Asn Arg Leu Leu Pro Thr Ile Pro Ala Asp 450 455 460 Glu Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gin Ala Arg Lys 465 470 475 480 Val Ile Asn Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 485 490 495 Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Gin Asp Arg Lys Lys 500 505 510 Leu Glu Lys Gin Gin Glu Asp Asn Arg Lys His Arg Glu Ser Ala Val 515 520 525 Gin Lys Phe Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly 530 535 540 Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Leu Gin Gin Ala Lys Cys 545 550 555 560 Leu Tyr Ser Gly Lys Ser Leu Glu Leu His Arg Leu Leu Glu Lys Gly 565 570 575 Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 580 585 590 Ser Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gin Asn Lys 595 600 605 Gly Asn Leu Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu 610 615 620 Pro Trp Gin Asn Phe Val Ala Arg Val Gin Thr Ser Gly Phe Ser His 625 630 635 640 Thr Lys Lys Gin Arg Ile Leu Ser His Lys Leu Asp Glu Lys Gly Phe 645 650 655 Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Val Arg Phe Leu Cys 660 665 670 Page 832 of 3790 Asn Phe Ile Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys 675 680 685 Val Phe Ala Ser Asn Gly Gin Ile Thr Ala Leu Leu Arg Gly Arg Trp 690 695 700 Gly Leu Gin Lys Val Arg Asp Asp Asn Asp Arg His His Ala Leu Asp 705 710 715 720 Ala Val Val Val Ala Cys Ser Thr Val Ala Met Gin Gin Lys Ile Thr 725 730 735 Arg Phe Val Arg Tyr Glu Glu Gly Asn Val Phe Ser Gly Glu Arg Ile 740 745 750 Asp Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ser Pro Trp 755 760 765 Ala Phe Phe Arg Glu Asn Val Glu Ile Arg Ile Phe Ser Glu Asn Pro 770 775 780 Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr Pro Gin Tyr Asn His 785 790 795 800 Glu Phe Val Gin Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met 805 810 815 Thr Gly Gin Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asp 820 825 830 Glu Gly Leu Ser Val Leu Lys Val Pro Leu Thr Gin Leu Lys Leu Asn 835 840 845 Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu Met Ala Leu Tyr Glu 850 855 860 Ser Leu Lys Val Arg Leu Glu Gin Phe Asp Asn Asp Pro Ala Lys Ala 865 870 875 880 Phe Ala Glu Pro Phe Tyr Lys Lys Gly Gly Ala Leu Val Lys Ala Val 885 890 895 Arg Val Glu Gin Thr Gin Lys Ser Gly Val Leu Val Arg Asp Gly Asn 900 905 910 Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys Page 833 of 3790 Arg 169 1369 PRT Lactobacillus iners 169 Met Asn Asn Asn Tyr Tyr Leu Gly Leu Asp Leu Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Thr Asp Asp His Tyr Asn Ile Ile Lys Phe His Gly 20 25 30 Lys His Met Trp Gly Met Arg Leu Phe Glu Glu Ala Glu Thr Ala Lys 35 40 45 Asp Arg Arg Leu His Arg Gin Ala Arg Arg Arg Arg Gin Arg Leu Val 50 55 60 Glu Arg Ile Asn Leu Leu Glu Glu Leu Phe Asp Lys Glu Ile Ser Lys Page 835 of 3790 His Lys Ser Asp Leu Lys Arg Leu Lys Ser Leu Ile Lys Lys Tyr Leu 325 330 335 Pro Ser Glu Tyr Asn Asn Ile Phe Arg Lys Ile Thr Glu Lys Asp Asn 340 345 350 Tyr Val Ala Tyr Ser Lys Ser Asn Ile Thr Asn Asn Lys Arg Glu Lys 355 360 365 Ala Leu Lys Tyr Val Lys Tyr Val Asp Phe Thr Lys Tyr Leu Thr Lys 370 375 380 Lys Leu Lys Thr Ile Lys Thr Gin Asp Ala Glu Asp Asp Gin Glu Ile 385 390 395 400 Phe Glu Ile Lys Gly Glu Leu Glu Lys Gin Ser Phe Leu Pro Lys Gin 405 410 415 Arg Thr Leu Asp Asn Ser Ile Ile Pro Tyr Gin Leu His Leu Met Glu 420 425 430 Leu Lys Lys Ile Leu Asp Asn Gin Ser Lys Tyr Tyr Asp Phe Leu Leu 435 440 445 Ala Lys Asp Asp Gin Glu Gly Ile Thr Val Lys Asp Lys Ile Ile Ser 450 455 460 Leu Leu Thr Phe Arg Leu Pro Tyr Tyr Ile Gly Pro Val Asn Pro Ala 465 470 475 480 Val His Gly Lys Phe Ala Trp Val 485 Lys Arg Leu Ala Asn 490 Gly Lys 495 Val Thr Pro Trp Asn 500 Tyr Lys Glu Lys Ile Asp 505 Ile Asp Ala Ser His 510 Glu Glu Phe Ile Lys 515 Thr Lys Leu Ser Lys 520 Cys Ser Phe Leu 525 Ile Gly Cys Asp Val 530 Leu Pro Lys Asn Ser Leu Leu 535 Tyr Gin Lys 540 Tyr Met Val Leu Ser Glu Leu Asn Thr 545 Ile Lys 550 Phe Asn Gly Val 555 Asn Ile Ser Glu Lys 560 Leu Lys Asp Asp Ile Tyr Gin Asn Leu Phe Lys Asn Ile Gin Lys Val 565 570 575 Page 836 of 3790 Thr Lys Lys Arg Leu Gin Asn Tyr Ile Lys Glu His Glu Asn Ile Ile 580 585 590 Gly Asp Val Ile Val Thr Gly Ile Asp Asn Ala Phe Lys Gin Gly Leu 595 600 605 Val Ser Tyr Leu Lys Phe Lys Lys Ile Ile Gly Asp Lys Val Asp Asp 610 615 620 Asp Arg Tyr Gin Lys Val Leu Glu Lys Ile Ile Arg Asp Ile Thr Leu 625 630 635 640 Tyr Asp Glu Cys Ala Gly Lys Lys Ile Lys Lys Glu Tyr Lys Asp Ser 645 650 655 Asp Leu Phe Thr Glu Asp Glu Leu Asn Lys Ile Val Lys Leu Thr Phe 660 665 670 Asn Asp Trp Gly Arg Leu Ser Ala Glu Leu Leu Asp Gin Leu Glu Gly 675 680 685 Glu Asp Thr Val Ser Gly Glu Thr Gly Lys Ile Ile Glu Phe Met Gin 690 695 700 Lys His Asn Tyr Asn Leu Met Gin Leu Met Ser Lys Lys Phe Thr Phe 705 710 715 720 Lys Ser Lys Ile Asp Glu Ile Asn Lys Ser Tyr Tyr Gin His Asp Lys 725 730 735 Phe Asn Tyr Lys Ser Met Ile Asp Ser Leu Tyr Val Ser Pro Ala Thr 740 745 750 Lys Arg Ile Leu Trp Gin Ser Leu Lys Val Val His Glu Ile Ser Lys 755 760 765 Ile Met Lys His Asp Pro Glu Lys Ile Phe Ile Glu Met Ala Arg Ser 770 775 780 Lys Glu Asp His Pro Lys Arg Lys Leu Ser Arg Lys Ala Asp Leu Lys 785 790 795 800 Gin Val Tyr Lys Asp Ser Lys Lys Gin Ile Ile Ser Ile Ile Gly Lys 805 810 815 Asp Lys Tyr Gin Asp Leu Ser Asn Glu Leu Asp Asn Lys Asp Asp Arg 820 825 830 Page 837 of 3790 Asn Gly Thr Ile Ala Asn Val Lys Cys Asn Leu Ser Thr Lys Asp Page 839 of 3790 Leu 170 1420 PRT Bifidobacterium bifidum 170 Met Ser Arg Lys Asn Tyr Val Asp Asp Tyr Ala Ile Ser Leu Asp Ile 15 10 15 Gly Asn Ala Ser Val Gly Trp Ser Ala Phe Thr Pro Asn Tyr Arg Leu 20 25 30 Val Arg Ala Lys Gly His Glu Leu Ile Gly Val Arg Leu Phe Asp Pro 35 40 45 Ala Asp Thr Ala Glu Ser Arg Arg Met Ala Arg Thr Thr Arg Arg Arg 50 55 60 Tyr Ser Arg Arg Arg Trp Arg Leu Arg Leu Leu Asp Ala Leu Phe Asp 65 70 75 80 Gin Ala Leu Ser Glu Ile Asp Pro Ser Phe Leu Ala Arg Arg Lys Tyr 85 90 95 Ser Trp Val His Pro Asp Asp Glu Asn Asn Ala Asp Cys Trp Tyr Gly 100 105 110 Ser Val Leu Phe Asp 115 Ser Asn Glu Gin Asp 120 Lys Arg Phe 125 Tyr Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Met Glu Asp Asp Ser 130 135 140 Page 841 of 3790 Lys Ala Asn Val Phe Phe Lys Lys Met Ile Glu Thr Ser Asp Leu Ser 405 410 415 Glu Thr Asp Lys Asn Arg Leu Ile His Asp Ile Glu Glu Asp Lys Leu 420 425 430 Phe Pro Ile Gin Arg Asp Ser Asp Asn Gly Val Ile Pro His Gin Leu 435 440 445 His Gin Asn Glu Leu Lys Gin Ile Ile Lys Lys Gin Gly Lys Tyr Tyr 450 455 460 Pro Phe Leu Leu Asp Ala Phe Glu Lys Asp Gly Lys Gin Ile Asn Lys 465 470 475 480 Ile Glu Gly Leu Leu Thr Phe Arg Val Pro Tyr Phe Val Gly Pro Leu 485 490 495 Val Val Pro Glu Asp Leu Gin Lys Ser Asp Asn Ser Glu Asn His Trp 500 505 510 Met Val Arg Lys Lys Lys Gly Glu Ile Thr Pro Trp Asn Phe Asp Glu 515 520 525 Met Val Asp Lys Asp Ala Ser Gly Arg Lys Phe Ile Glu Arg Leu Val 530 535 540 Gly Thr Asp Ser Tyr Leu Leu Gly Glu Pro Thr Leu Pro Lys Asn Ser 545 550 555 560 Leu Leu Tyr Gin Glu Tyr Glu Val Leu Asn Glu Leu Asn Asn Val Arg 565 570 575 Leu Ser Val Arg Thr Gly Asn His Trp Asn Asp Lys Arg Arg Met Arg 580 585 590 Leu Gly Arg Glu Glu Lys Thr Leu Leu Cys Gin Arg Leu Phe Met Lys 595 600 605 Gly Gin Thr Val Thr Lys Arg Thr Ala Glu Asn Leu Leu Arg Lys Glu 610 615 620 Tyr Gly Arg Thr Tyr Glu Leu Ser Gly Leu Ser Asp Glu Ser Lys Phe 625 630 635 640 Thr Ser Ser Leu Ser Thr Tyr Gly Lys Met Cys Arg Ile Phe Gly Glu 645 650 655 Page 842 of 3790 Lys Tyr Val Asn Glu His Arg Asp Leu Met Glu Lys Ile Val Glu Leu 660 665 670 Gin Thr Val Phe Glu Asp Lys Glu Thr Leu Leu His Gin Leu Arg Gin 675 680 685 Leu Glu Gly Ile Ser Glu Ala Asp Cys Ala Leu Leu Val Asn Thr His 690 695 700 Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Leu Thr Thr Lys Ala 705 710 715 720 Gly Glu Cys Lys Ile Ser Asp Asp Phe Ala Pro Arg Lys His Ser Ile 725 730 735 Ile Glu Ile Met Arg Ala Glu Asp Arg Asn Leu Met Glu Ile Ile Thr 740 745 750 Asp Lys Gin Leu Gly Phe Ser Asp Trp Ile Glu Gin Glu Asn Leu Gly 755 760 765 Ala Glu Asn Gly Ser Ser Leu Met Glu Val Val Asp Asp Leu Arg Val 770 775 780 Ser Pro Lys Val Lys Arg Gly Ile Ile Gin Ser Ile Arg Leu Ile Asp 785 790 795 800 Asp Ile Ser Lys Ala Val Gly Lys Arg Pro Ser Arg Ile Phe Leu Glu 805 810 815 Leu Ala Asp Asp Ile Gin Pro Ser Gly Arg Thr Ile Ser Arg Lys Ser 820 825 830 Arg Leu Gin Asp Leu Tyr Arg Asn Ala Asn Leu Gly Lys Glu Phe Lys 835 840 845 Gly Ile Ala Asp Glu Leu Asn Ala Cys Ser Asp Lys Asp Leu Gin Asp 850 855 860 Asp Arg Leu Phe Leu Tyr Tyr Thr Gin Leu Gly Lys Asp Met Tyr Thr 865 870 875 880 Gly Glu Glu Leu Asp Leu Asp Arg Leu Ser Ser Ala Tyr Asp Ile Asp 885 890 895 His Ile Ile Pro Gin Ala Val Thr Gin Asn Asp Ser Ile Asp Asn Arg 900 910 Page 843 of 3790 905 Page 845 of 3790 171 1092 PRT llyobacter polytropus 171 Glu Ile Ala Gin 115 Ile Leu Leu His 120 Ile Ala Lys Arg Arg Gly 125 Phe Lys Ser Phe Arg Lys 130 Thr Asp Arg 135 Asn Ala Asp Asp Thr Gly Lys 140 Leu Leu Ser Gly 145 Ile Gin Glu Asn Lys 150 Lys Ile Met Glu Glu Lys 155 Gly Tyr Leu 160 Thr Ile Gly Asp Met Val Ala Lys Asp Pro Lys Phe Asn Thr His Val 165 170 175 Page 846 of 3790 Arg Asn Lys Ala Gly Ser Tyr Leu Phe Ser Phe Ser Arg Lys Leu Leu 180 185 190 Glu Asp Glu Val Arg Lys Ile Gin Ala Lys Gin Lys Glu Leu Gly Asn 195 200 205 Thr His Phe Thr Asp Asp Val Leu Glu Lys Tyr Ile Glu Val Phe Asn 210 215 220 Ser Gin Arg Asn Phe Asp Glu Gly Pro Ser Lys Pro Ser Pro Tyr Tyr 225 230 235 240 Ser Glu Ile Gly Gin Ile Ala Lys Met Ile Gly Asn Cys Thr Phe Glu 245 250 255 Ser Ser Glu Lys Arg Thr Ala Lys Asn Thr Trp Ser Gly Glu Arg Phe 260 265 270 Val Phe Leu Gin Lys Leu Asn Asn Phe Arg Ile Val Gly Leu Ser Gly 275 280 285 Lys Arg Pro Leu Thr Glu Glu Glu Arg Asp Ile Val Glu Lys Glu Val 290 295 300 Tyr Leu Lys Lys Glu Val Arg Tyr Glu Lys Leu Arg Lys Ile Leu Tyr 305 310 315 320 Leu Lys Glu Glu Glu Arg Phe Gly Asp Leu Asn Tyr Ser Lys Asp Glu 325 330 335 Lys Gin Asp Lys Lys Thr Glu Lys Thr Lys Phe Ile Ser Leu Ile Gly 340 345 350 Asn Tyr Thr Ile Lys Lys Leu Asn Leu Ser Glu Lys Leu Lys Ser Glu 355 360 365 Ile Glu Glu Asp Lys Ser Lys Leu Asp Lys Ile Ile Glu Ile Leu Thr 370 375 380 Phe Asn Lys Ser Asp Lys Thr Ile Glu Ser Asn Leu Lys Lys Leu Glu 385 390 395 400 Leu Ser Arg Glu Asp Ile Glu Ile Leu Leu Ser Glu Glu Phe Ser Gly 405 410 415 Thr Leu Asn Leu Ser Leu Lys Ala Ile Lys Lys Ile Leu Pro Tyr Leu 420 425 430 Page 847 of 3790 Glu Lys Gly Leu Ser Tyr Asn Glu Ala Cys Glu Lys Ala Asp Tyr Asp 435 440 445 Tyr Lys Asn Asn Gly Ile Lys Phe Lys Arg Gly Glu Leu Leu Pro Val 450 455 460 Val Asp Lys Asp Leu Ile Ala Asn Pro Val Val Leu Arg Ala Ile Ser 465 470 475 480 Gin Thr Arg Lys Val Val Asn Ala Ile Ile Arg Lys Tyr Gly Thr Pro 485 490 495 His Thr Ile His Val Glu Val Ala Arg Asp Leu Ala Lys Ser Tyr Asp 500 505 510 Asp Arg Gin Thr Ile Ile Lys Glu Asn Lys Lys Arg Glu Leu Glu Asn 515 520 525 Glu Lys Thr Lys Lys Phe Ile Ser Glu Glu Phe Gly Ile Lys Asn Val 530 535 540 Lys Gly Lys Leu Leu Leu Lys Tyr Arg Leu Tyr Gin Glu Gin Glu Gly 545 550 555 560 Arg Cys Ala Tyr Ser Arg Lys Glu Leu Ser Leu Ser Glu Val Ile Leu 565 570 575 Asp Glu Ser Met Thr Asp Ile Asp His Ile Ile Pro Tyr Ser Arg Ser 580 585 590 Met Asp Asp Ser Tyr Ser Asn Lys Val Leu Val Leu Ser Gly Glu Asn 595 600 605 Arg Lys Lys Ser Asn Leu Leu Pro Lys Glu Tyr Phe Asp Arg Gin Gly 610 615 620 Arg Asp Trp Asp Thr Phe Val Leu Asn Val Lys Ala Met Lys Ile His 625 630 635 640 Pro Arg Lys Lys Ser Asn Leu Leu Lys Glu Lys Phe Thr Arg Glu Asp 645 650 655 Asn Lys Asp Trp Lys Ser Arg Ala Leu Asn Asp Thr Arg Tyr Ile Ser 660 665 670 Arg Phe Val Ala Asn Tyr Leu Glu Asn Ala Leu Glu Tyr Arg Asp Asp Page 848 of 3790 675 680 685 Ser Pro Lys Lys Arg Val Phe Met Ile Pro Gly Gin Leu Thr Ala Gin 690 695 700 Leu Arg Ala Arg Trp Arg Leu Asn Lys Val Arg Glu Asn Gly Asp Leu 705 710 715 720 His His Ala Leu Asp Ala Ala Val Val Ala Val Thr Asp Gin Lys Ala 725 730 735 Ile Asn Asn Ile Ser Asn Ile Ser Arg Tyr Lys Glu Leu Lys Asn Cys 740 745 750 Lys Asp Val Ile Pro Ser Ile Glu Tyr His Ala Asp Glu Glu Thr Gly 755 760 765 Glu Val Tyr Phe Glu Glu Val Lys Asp Thr Arg Phe Pro Met Pro Trp 770 775 780 Ser Gly Phe Asp Leu Glu Leu Gin Lys Arg Leu Glu Ser Glu Asn Pro 785 790 795 800 Arg Glu Glu Phe Tyr Asn Leu Leu Ser Asp Lys Arg Tyr Leu Gly Trp 805 810 815 Phe Asn Tyr Glu Glu Gly Phe Ile Glu Lys Leu Arg Pro Val Phe Val 820 825 830 Ser Arg Met Pro Asn Arg Gly Val Lys Gly Gin Ala His Gin Glu Thr 835 840 845 Ile Arg Ser Ser Lys Lys Ile Ser Asn Gin Ile Ala Val Ser Lys Lys 850 855 860 Pro Leu Asn Ser Ile Lys Leu Lys Asp Leu Glu Lys Met Gin Gly Arg 865 870 875 880 Asp Thr Asp Arg Lys Leu Tyr Glu Ala Leu Lys Asn Arg Leu Glu Glu 885 890 895 Tyr Asp Asp Lys Pro Glu Lys Ala Phe Ala Glu Pro Phe Tyr Lys Pro 900 905 910 Thr Asn Ser Gly Lys Arg Gly Pro Leu Val Arg Gly Ile Lys Val Glu 915 920 925 Page 849 of 3790 1085 1090 172 994 PRT Page 850 of 3790 Ile Asn Gly Asn Val Ile Lys Thr Ile Lys Lys Asn Met Ser Ser Val 50 55 60 Leu Ile Phe Asp Glu Ala Asn Pro Ala Lys Gly Ala Arg Thr Lys Arg 65 70 75 80 Thr Ser Arg Arg Arg Tyr Thr Arg Arg Asn Phe Arg Leu Leu Glu Leu 85 90 95 Lys Lys Leu Phe Glu Lys Glu Ile Glu Lys Ile Asp Pro Asn Phe Phe 100 105 110 His Arg Ile Lys Glu Asp Ser Phe Phe Asn Trp Asn Asp Lys Glu Phe 115 120 125 Asp Lys His Pro Leu Phe Gly Asn Leu Lys Glu Glu Lys Lys Phe His 130 135 140 Asn Asn Tyr Pro Thr Val Phe His Leu Arg Asn Glu Ile Gly Lys Asn 145 150 155 160 Ser Ser Lys Lys Phe Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 165 170 175 Ile Ile Lys Tyr Arg Gly His Phe Leu Asp Glu Thr Phe Asp Pro Asp 180 185 190 Ala Ser Val Ser Val Glu Lys Arg Leu Asn Asp Phe Ile Val Glu Tyr 195 200 205 Asn Glu Leu Phe Asp Lys Asp Leu Arg Ser Glu Ala Lys Phe Ser Glu 210 215 220 Ile Leu Met Ser Asp Ser Ser Asn Ser Val Lys Ile Glu Ser Thr Leu 225 230 235 240 Ser Leu Tyr Pro Ser Glu Lys Asn Thr Ile Phe Gin Val Phe Leu Lys 245 250 255 Leu Ile Val Gly Asn Gin Gly Asp Phe Asn Lys Phe Phe Lys Asp Glu 260 265 270 Leu Glu Ser Ser Ser His Ser Gly Lys Leu Val Phe Ser Ser Asp Glu 275 280 285 Val Glu Asp Glu Lys Glu Glu Leu Ile Ser Ile Ile Gly Glu Asp Tyr 290 295 300 Page 851 of 3790 Leu Asp Ile Ile Asn Leu Cys Gin Ser Leu Tyr Ser Thr Val Ala Leu 305 310 315 320 Ala Lys Ile Ile Ser Thr Asp Thr Gly Glu Ser Asn Thr Pro Leu Ser 325 330 335 Ala Ser Met Val Lys Arg Tyr Asn Glu His Lys Gly Asp Leu Ala Asn 340 345 350 Leu Lys Gly Ile Val Lys His Phe Ile Pro Glu Lys Tyr Glu Glu Val 355 360 365 Phe Gly Glu His Ser Lys Thr Gly Tyr Thr Ala Tyr Ile Arg Asn Pro 370 375 380 Asn Lys Met Pro Glu Lys Lys Phe Tyr Asp Tyr Leu Tyr His Glu Gly 385 390 395 400 Glu Lys Gly Lys Ile Ser Gly Ile Leu Ser Asp Ser Arg Ile Tyr Glu 405 410 415 Leu Pro Ala Val Gin Lys Phe Ile Leu Lys Ile Glu Gin Lys Ser Phe 420 425 430 Leu Lys Lys Gin Arg Thr Lys Glu Asn Gly Leu Ile Pro Tyr Gin Leu 435 440 445 His Leu Lys Glu Leu Lys Ile Ile Ile Glu Asn Gin Ser Glu Tyr Tyr 450 455 460 Pro Phe Leu His Glu Ile Glu Glu Lys Leu Glu Lys Leu Leu Thr Phe 465 470 475 480 Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Gin Thr Lys Tyr Ile Asn 485 490 495 Pro Arg Phe Asn Trp Leu Val Arg Lys Ser Glu Asp His Ile Lys Pro 500 505 510 Trp Asn Phe Ser Glu Ile Val Asp Glu Glu Lys Ser Ala Thr Lys Phe 515 520 525 Ile Glu Lys Leu Ile Ser Asn Asp Gin Phe Leu Phe Gly Glu Lys Val 530 535 540 Leu Pro Lys Arg Ser Ile Ile Tyr Gin Gin Phe Leu Ile Phe Asn Glu 545 550 555 560 Page 852 of 3790 Leu Thr Lys Val Ser Tyr Gin Ile Lys Asp Gly Pro Ser Arg Asn Phe 565 570 575 Asp Ser Glu Thr Lys Glu Glu Ile Phe Asn Ser Leu Phe Lys Lys Asn 580 585 590 Lys Leu Gly Cys Val Thr Val Val Asp Leu Lys Asn Tyr Ile Lys Asn 595 600 605 Asp Gin Cys Leu Ser Glu Lys Glu Asp Ile Gin Ile Glu Gly Ile Lys 610 615 620 Lys Lys Phe Asn Ser Ser Tyr Ser Thr Tyr Ala Asp Leu Ser Glu Ile 625 630 635 640 Ser Gly Leu Lys Glu Leu Leu Asp Asp Asp Thr Gin Leu Asp Leu Val 645 650 655 Glu Glu Ile Ile Arg Ile Leu Thr Val Phe Glu Asp Lys Lys Met Arg 660 665 670 Thr Lys Gin Leu Glu Lys Leu Asn Leu Pro Ala Asn Val Asp Ile Glu 675 680 685 Lys Leu Cys Lys Lys His Tyr Lys Gly Trp Ala Asn Val Ser Arg Gin 690 695 700 Leu Ile Asp Gly Ile Ala Asp Arg Ser Arg Gly Phe Lys Lys Thr Ile 705 710 715 720 Leu Asp Tyr Leu Lys Asp Asp Asp Ile Pro Asn Asn Asp Ala Phe Ser 725 730 735 Thr Lys Val Gin Lys Ser Leu Asn Arg Asn Phe Ala Gin Leu Ile Thr 740 745 750 Asp Lys Ser Leu Asp Phe Ala Arg Lys Leu Asp Glu Ser Tyr Lys Ile 755 760 765 Asp Val Lys Lys Asp Tyr Pro Ser Leu Val Glu Asp Ile Pro Gly Ser 770 775 780 Pro Ala Ile Arg Arg Ala Ile Leu Gin Ser Leu Tyr Thr Val Asp Glu 785 790 795 800 Ile Ile Gly Val Met Gly Arg Met Pro Lys Asn Ile Val Ile Glu Met Asn Arg 173 1052 PRT Aminomonas paucivorans 173 Met Ile Gly Glu His Val Arg Gly Gly Cys Leu Phe Asp Asp His Trp 15 10 15 Thr Pro Asn Trp Gly Ala Phe Arg Leu Pro Asn Thr Val Arg Thr Phe Page 856 of 3790 Asp Ile Val Gly Thr Ala Pro Gly Pro Gly Asp Leu Leu Lys Met Arg 530 535 540 Leu Trp Arg Glu Gin Gly Gly Phe Cys Pro Tyr Cys Glu Glu Tyr Leu 545 550 555 560 Asn Pro Thr Arg Leu Ala Glu Pro Gly Tyr Ala Glu Met Asp His Ile 565 570 575 Leu Pro Tyr Ser Arg Ser Leu Asp Asn Gly Trp His Asn Arg Val Leu 580 585 590 Val His Gly Lys Asp Asn Arg Asp Lys Gly Asn Arg Thr Pro Phe Glu 595 600 605 Ala Phe Gly Gly Asp Thr Ala Arg Trp Asp Arg Leu Val Ala Trp Val 610 615 620 Gin Ala Ser His Leu Ser Ala Pro Lys Lys Arg Asn Leu Leu Arg Glu 625 630 635 640 Asp Phe Gly Glu Glu Ala Glu Arg Glu Leu Lys Asp Arg Asn Leu Thr 645 650 655 Asp Thr Arg Phe Ile Thr Lys Thr Ala Ala Thr Leu Leu Arg Asp Arg 660 665 670 Leu Thr Phe His Pro Glu Ala Pro Lys Asp Pro Val Met Thr Leu Asn 675 680 685 Gly Arg Leu Thr Ala Phe Leu Arg Lys Gin Trp Gly Leu His Lys Asn 690 695 700 Arg Lys Asn Gly Asp Leu His His Ala Leu Asp Ala Ala Val Leu Ala 705 710 715 720 Val Ala Ser Arg Ser Phe Val Tyr Arg Leu Ser Ser His Asn Ala Ala 725 730 735 Trp Gly Glu Leu Pro Arg Gly Arg Glu Ala Glu Asn Gly Phe Ser Leu 740 745 750 Pro Tyr Pro Ala Phe Arg Ser Glu Val Leu Ala Arg Leu Cys Pro Thr 755 760 765 Arg Glu Glu Ile Leu Leu Arg Leu Asp Gin Gly Gly Val Gly Tyr Asp 770 775 780 Page 857 of 3790 Lys Asp Val Leu Ser Met Ser Lys Tyr Gin Val Asp Pro Leu Gly Page 858 of 3790 1025 1030 1035 Glu Ile Arg Leu Val Gly Ser Glu Lys Pro Pro Phe Val Leu 1040 1045 1050 Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gin Page 859 of 3790 195 200 205 Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gin Arg Gin 210 215 220 Phe Gly Phe Ser Leu Lys Gin Asp Phe Glu Asn Lys Leu Leu Thr Lys 225 230 235 240 Ile Phe Glu Gin Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 245 250 255 Cys Cys Phe Ile Ala Gly Glu Lys Arg Ala Pro Lys Asp Ser Pro Ser 260 265 270 Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 275 280 285 Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gin 290 295 300 Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 305 310 315 320 Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 325 330 335 Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 340 345 350 Glu Phe Lys Gin Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe 355 360 365 Thr Thr Leu Ala Ile Ser Gin Leu Asp Glu Ile Ala Glu His Ile Ala 370 375 380 Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 385 390 395 400 Leu Thr Lys Glu Gin Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 405 410 415 His Ile Asn Leu Ser Leu Gin Ala Leu Lys Gin Ile Leu Pro Phe Met 420 425 430 Arg Gly Asp Asn Gly Glu Gin Cys Leu Asp Tyr Asp Glu Ser Val Glu 435 440 445 Page 860 of 3790 Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gin Met 450 455 460 Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 465 470 475 480 Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Val Leu Leu Lys 485 490 495 Gin Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 500 505 510 Lys Leu Ser Ser Thr Glu Arg Gin Lys Tyr Glu Lys Glu Gin Lys Asp 515 520 525 Asn Tyr Ala Ala Asn Gin Ala Ala His Lys Lys Cys Gin Glu Leu Gly 530 535 540 Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gin Glu 545 550 555 560 Gin Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr 565 570 575 Leu Gin Asp Pro Thr Ala Leu Gin Val Asp His Ile Tyr Pro Tyr Ser 580 585 590 Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Cys Leu Val Leu Thr Lys 595 600 605 Ala Asn Gin Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly Thr 610 615 620 Asp Ser Ala Lys Trp Gly Val Ile Thr Thr Leu Ala Gin Lys Leu Pro 625 630 635 640 His Lys Lys Arg Arg Arg Ile Leu Asn Thr Ala Phe Asn Asp Lys Glu 645 650 655 Ala Gly Phe Lys Leu Arg Asn Leu Asn Asp Thr Ser Tyr Ile Ala Arg 660 665 670 Leu Val Ala Asp Tyr Thr Glu Thr Tyr Leu Glu Phe Leu Pro Leu Val 675 680 685 Glu Ser Glu Asn Thr Thr Leu Ser Lys Gly Gin Lys Gly Ser Lys Lys 690 695 700 Page 861 of 3790 His Ile Ala Ile Val Asn Gly Val Leu Thr Ser Thr Met Arg Tyr Tyr 705 710 715 720 Leu Gly Phe Ala Ser Lys Asp Arg Asp Asn His Leu His His Ala Leu 725 730 735 Asp Ala Val Ile Ile Gly Phe Met Asn Asp Ser Val Ile Lys Ala Phe 740 745 750 Ser Asp Phe Lys Lys Thr Gin Glu Thr Ser Lys Ala Ala Tyr Tyr Ala 755 760 765 His Thr Leu Ser Lys Gin Glu Tyr Lys Lys Gin Arg Ala Phe Ile Gin 770 775 780 Leu Pro Ser Gly Glu Asn Phe Arg Val Ser Val Leu Glu Lys Val Glu 785 790 795 800 Ser Val Phe Val Ser Lys Pro Pro Arg Lys Arg Val Arg Gly Ala Leu 805 810 815 His Glu Ala Thr Phe Tyr Ser Pro Asn Asp Pro Lys Leu Leu Lys Asn 820 825 830 Tyr Gly Gly Thr Lys Gly Val Glu Arg Ala Leu Ala Leu Gly Lys Met 835 840 845 Arg Lys Val Gly Ala Lys Ile Val Ser Asn Gly Ala Met Val Arg Val 850 855 860 Asp Ile Phe Arg His Lys Ser Ser Gly Lys Phe Tyr Gly Val Pro Val 865 870 875 880 Tyr Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val 885 890 895 Val Gly Lys Asp Gin Asn Gly Val Ile Lys Asp Trp Leu Glu Met Asp 900 905 910 Ser Ser Tyr Glu Phe Ile Phe Ser Leu Tyr Lys Asp Asp Val Ile Leu 915 920 925 Val Gin Lys Lys Glu Met Gin Arg Pro Glu Leu Cys Tyr Phe Val Ser 930 935 940 Phe Asp Thr Ser Gly Ala Ser Ile Lys Val Ala Lys His Asp Asn Asn 945 950 955 960 Page 862 of 3790 Page 863 of 3790 Glu Glu Ile Ile Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile 165 170 175 Asn Glu Arg Leu Gin Glu Phe Ser Asn Val Leu Asp Glu Ala Val Leu 180 185 190 Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala 195 200 205 Lys Leu Leu Ile Gly Ile Arg Asp Lys Glu Ser His Leu Thr Ile Leu 210 215 220 Asp Tyr Leu Met Asn Asp Asp Lys His Asn Arg Asn Leu Met Gin Leu 225 230 235 240 Ile Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin 245 250 255 Val Ser Thr Ala Asp Lys Asp Ile Gin Ser Ile Val Ala Asp Leu Ala 260 265 270 Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val 275 280 285 Asp Glu Leu Val Gly Ile Met Gly Tyr Pro Pro Gin Thr Ile Val Val 290 295 300 Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Lys Gly Lys Asn Asn Ser 305 310 315 320 Lys Pro Arg Phe Thr Ser Leu Glu Lys Ala Ile Lys Glu Leu Gly Ser 325 330 335 Gin Ile Leu Lys Glu His Pro Thr Asp Asn Gin Gly Leu Lys Asn Asp 340 345 350 Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly 355 360 365 Gin Glu Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Val 370 375 380 Val Pro Gin Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Arg Val Leu 385 390 395 400 Ala Ser Ser Ala Ala Asn Arg Glu Lys Gly Asp Asn Val Pro Ser Leu Page 866 of 3790 Met Ala Ala Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp 15 10 15 Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Lys Glu 20 25 30 Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 35 40 45 Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 50 55 60 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 65 70 75 80 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gin Asp Ala Asp 85 90 95 Phe Asp Glu Asn Gly Leu Val Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Cys Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asp Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Asn Leu Leu Phe Glu Lys Gin Lys Glu Phe Ser Asn 210 215 220 Pro His Val Ser Asp Ser Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Ala Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 Page 867 of 3790 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Pro Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Thr Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Lys Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Cys Lys Lys Asn Ala Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Cys Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Page 868 of 3790 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp His Ile Leu Leu Thr 675 680 685 Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin Page 869 of 3790 Arg Leu Lys Arg Thr Asn Arg Arg Arg Tyr Thr Arg Arg Arg Tyr Arg 20 25 30 Leu Cys Gin Leu Gin Asn Ile Phe Ala Thr Glu Met Val Lys Val Asp 35 40 45 Asp Thr Phe Phe Gin Arg Leu Ser Glu Ser Phe Phe Tyr Tyr Gin Asp 50 55 60 Lys Ala Phe Asp Lys His Pro Ile Phe Gly Asn Ser Lys Glu Glu Arg 65 70 75 80 Ala Tyr His Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu 85 90 95 Ala Asp Arg Asp Gin Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 100 105 110 Ser His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu 115 120 125 Asn Ser Glu Asn Thr Asp Val Gin Lys Leu Phe Ile Ala Leu Val Thr 130 135 140 Page 871 of 3790 Val Tyr Asn Leu Leu Phe Glu Glu Glu Pro Ile Ala Gly Glu Thr Cys 145 150 155 160 Asp Ala Lys Ala Leu Leu Thr Ala Lys Thr Ser Lys Ser Lys Arg Leu 165 170 175 Glu Ser Leu Ile Ser Glu Phe Pro Gly Gin Lys Lys Asn Gly Leu Phe 180 185 190 Gly Asn Leu Leu Ala Leu Ala Leu Gly Leu Arg Pro Asn Phe Lys Ser 195 200 205 Asn Phe Gly Leu Ser Glu Asp Ala Lys Leu Gin Ile Thr Lys Asp Thr 210 215 220 Tyr Glu Glu Glu Leu Asp Asn Leu Leu Ala Glu Ile Gly Asp His Tyr 225 230 235 240 Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 245 250 255 Ser Asp Ile Leu Thr Leu Ser Asp Glu Asn Thr Arg Ala Pro Leu Ser 260 265 270 Ala Ser Met Ile Lys Arg Tyr Glu Glu His Gin Glu Asp Leu Ala Leu 275 280 285 Leu Lys Lys Leu Val Lys Glu Gin Met Pro Glu Lys Tyr Trp Glu Ile 290 295 300 Phe Ser Asn Ala Lys Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 305 310 315 320 Val Ser Gin Glu Asp Phe Tyr Arg Tyr Ile Lys Pro Ile Leu Ser Arg 325 330 335 Leu Lys Gly Gly Asp Glu Phe Leu Ala Lys Ile Asp Arg Asp Asp Phe 340 345 350 Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile 355 360 365 His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gin Glu Lys Tyr Tyr 370 375 380 Pro Phe Leu Ala Glu Gin Lys Glu Lys Ile Glu Gin Leu Leu Cys Phe 385 390 395 400 Page 872 of 3790 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly Gly Asn Ser Ser 405 410 415 Phe Ala Trp Leu Lys Arg Arg Ser Asp Glu Pro Ile Thr Pro Trp Asn 420 425 430 Phe Lys Asp Val Val Asp Glu Glu Ala Ser Ala Gin Ala Phe Ile Glu 435 440 445 Gly Met Thr Asn Tyr Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro 450 455 460 Lys His Ser Pro Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr 465 470 475 480 Lys Val Lys Tyr Ile Ala Glu Asn Met Thr Lys Pro Leu Tyr Leu Ser 485 490 495 Ala Glu Gin Lys Glu Ala Ile Ile Asp His Leu Phe Lys Gin Thr Arg 500 505 510 Lys Val Thr Val Lys Asp Leu Lys Glu Lys Tyr Phe Ser Gin Ile Glu 515 520 525 Gly Leu Glu Asn Val Asp Val Thr Gly Val Glu Gly Ala Phe Asn Ala 530 535 540 Ser Leu Gly Thr Tyr Asn Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala 545 550 555 560 Phe Leu Asp Asp Glu Ala Asn Ala Glu Ile Leu Glu Glu Ile Val Leu 565 570 575 Ile Leu Thr Leu Phe Gin Asp Glu Lys Leu Ile Glu Lys Arg Leu Ala 580 585 590 Lys Tyr Ala Asn Leu Phe Glu Lys Ser Val Leu Lys Lys Leu Arg Lys 595 600 605 Arg His Tyr Arg Gly Trp Gly Arg Leu Ser Arg Gin Leu Ile Asp Gly 610 615 620 Met Lys Asp Lys Ala Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala 625 630 635 640 Asp Asp Phe Ala Asn Arg Asn Phe Ile Gin Leu Ile Asn Asp Ser Ser 645 650 655 Page 873 of 3790 Leu Asp Phe Glu Lys Leu Ile Asp Asp Ala Gin Lys Lys Ala Ile Lys 660 665 670 Arg Glu Ser Leu Thr Glu Ala Val Ala Asn Leu Ala Gly Ser Pro Ala 675 680 685 Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Val Val Asp Glu Ile Val 690 695 700 Lys Val Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ser Arg 705 710 715 720 Glu Asn Gin Thr Thr Ala Gin Gly Leu Lys Asn Ala Arg Gin Arg Leu 725 730 735 Lys Lys Ile Lys Glu Val His Lys Lys Thr Gly Ser Arg Ile Leu Glu 740 745 750 Asp Asn Ser Glu Arg Ile Thr Asn Leu Thr Leu Gin Asp Asn Arg Leu 755 760 765 Tyr Leu Tyr Leu Leu Gin Asp Gly Lys Asp Met Tyr Thr Gly Gin Asp 770 775 780 Leu Asp Ile Asn Asn Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro 785 790 795 800 Gin Ser Phe Ile Lys Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Thr 805 810 815 Gin Lys Ala Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val 820 825 830 Val Arg Asp Met Lys Asp Arg Val Trp Arg Arg Gin Leu Ala Asn Gly 835 840 845 Ala Ile Ser Arg Gin Lys Phe Asp His Leu Thr Lys Ala Glu Arg Gly 850 855 860 Gly Leu Ala Asp Ser Asp Lys Ala Arg Phe Leu Arg Arg Gin Leu Val 865 870 875 880 Glu Thr Arg Gin Ile Thr Lys His Val Ala Gin Leu Leu Asp Ser Arg 885 890 895 Phe Asn Ser Lys Ser Asn Gin Asn Lys Lys Leu Ala Arg Asn Val Lys 900 910 Page 874 of 3790 905 Page 875 of 3790 178 1150 PRT Enterococcus faecalis 178 Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 15 10 15 Page 877 of 3790 Leu Ser Leu Ser Ala Gin Gin Tyr Asn Leu Leu Asn Asp Leu Thr Asn 275 280 285 Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gin Lys Glu Tyr 290 295 300 Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 305 310 315 320 Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 325 330 335 Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 340 345 350 Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 355 360 365 Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 370 375 380 Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 385 390 395 400 Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 405 410 415 Ser Gin Ser Ile Ser Thr Gin Ser Trp His Arg Phe Ser Leu Lys Thr 420 425 430 Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gin Asn 435 440 445 Thr Leu Leu Glu Gin Phe Gin Leu Lys Ser Asp Val Arg Lys Arg Tyr 450 455 460 Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 465 470 475 480 Asn Pro Thr Val Asn Lys Thr Val Ser Gin Ala Phe Lys Val Ile Asp 485 490 495 Ala Leu Leu Val Lys Tyr Gly Lys Glu Gin Ile Arg Tyr Ile Thr Ile 500 505 510 Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 515 520 525 Page 878 of 3790 Glu Leu His Ala Lys Asn Ser Gin Arg Lys Asn Asp Ser Gin Ser Tyr 530 535 540 Phe Met Gin Lys Ser Gly Trp Ser Gin Glu Lys Phe Gin Thr Thr Ile 545 550 555 560 Gin Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gin 565 570 575 Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 580 585 590 Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 595 600 605 Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 610 615 620 Gin Val Lys Gly Gin Gin Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 625 630 635 640 Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gin Lys 645 650 655 Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 660 665 670 Glu Thr Arg Asn Ile Phe Asp Ser Glu Gin Val Glu Lys Phe Leu Ala 675 680 685 Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 690 695 700 Leu Gin Ser Phe Phe Thr Asn Gin Glu Thr Lys Val Arg Val Val Asn 705 710 715 720 Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 725 730 735 Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 740 745 750 Ala Val Thr Ser Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 755 760 765 Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly Thr Leu Gin 995 Ser Leu Lys Pro Tyr Arg Tyr Asp Ile Tyr Gin Asp Leu 1000 1005 Glu Thr 1010 Lys Ala Tyr Tyr Thr Val Gin Leu Tyr Tyr 1015 1020 Ser Asp Leu Page 880 of 3790 179 1150 PRT Enterococcus faecalis 179 Met Tyr Ser Ile Gly Leu Asp Leu Gly Val Ser Ser Val Gly Trp Ser 15 10 15 Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 20 25 30 Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 35 40 45 Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 50 55 60 Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 65 70 75 80 Page 881 of 3790 Asn Ser Cys Pro Tyr Gin Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 85 90 95 Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 100 105 110 Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 115 120 125 Gin Asp Tyr Lys Glu Gin Val Arg Glu Asn Ala Gin Leu Leu Thr Lys 130 135 140 Tyr Thr Pro Gly Gin Ile Gin Leu Gin Arg Leu Lys Glu Asn Asn Arg 145 150 155 160 Val Lys Thr Gly Ile Asn Ala Gin Gly Asn Tyr Gin Leu Asn Val Phe 165 170 175 Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gin 180 185 190 Gin Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 195 200 205 Val Gin Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 210 215 220 Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 225 230 235 240 Arg Trp Ser Asp Phe Lys Lys Thr Gly Gin Pro Ala Thr Asn Ile Phe 245 250 255 Asp Lys Leu Ile Gly Lys Asp Phe Gin Gly Glu Leu Arg Ala Ser Gly 260 265 270 Leu Ser Leu Ser Ala Gin Gin Tyr Asn Leu Leu Asn Asp Leu Thr Asn 275 280 285 Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Pro Glu Gin Lys Glu Tyr 290 295 300 Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Ile Asn 305 310 315 320 Asp Val Ala Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 325 330 335 Page 882 of 3790 Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 340 345 350 Arg Asn Trp Arg Lys Ile Phe Ala Glu Ser Gly Ile Asp Leu Ala Thr 355 360 365 Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 370 375 380 Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 385 390 395 400 Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 405 410 415 Ser Gin Ser Val Ser Thr Gin Ala Trp His Arg Phe Ser Leu Lys Thr 420 425 430 Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gin Asn 435 440 445 Thr Leu Leu Glu Gin Phe Gin Leu Lys Ser Asp Val Arg Lys Arg Tyr 450 455 460 Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 465 470 475 480 Asn Pro Thr Val Asn Lys Thr Val Ser Gin Ala Phe Lys Val Ile Asp 485 490 495 Ala Leu Leu Val Lys Tyr Gly Lys Glu Gin Ile Arg Tyr Ile Thr Ile 500 505 510 Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 515 520 525 Glu Leu His Ala Lys Asn Ser Gin Arg Lys Asn Asp Ser Gin Ser Tyr 530 535 540 Phe Met Gin Lys Ser Gly Trp Ser Gin Glu Lys Phe Gin Thr Thr Ile 545 550 555 560 Gin Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gin 565 570 575 Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 580 585 590 Page 883 of 3790 Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 595 600 605 Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 610 615 620 Gin Val Lys Gly Gin Gin Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 625 630 635 640 Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gin Lys 645 650 655 Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 660 665 670 Glu Thr Arg Asn Ile Phe Asp Ser Glu Gin Val Glu Lys Phe Leu Ala 675 680 685 Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 690 695 700 Leu Gin Ser Phe Phe Ala Asn Gin Glu Thr Lys Val Arg Val Val Asn 705 710 715 720 Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 725 730 735 Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 740 745 750 Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 755 760 765 Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 770 775 780 Glu Ile Val Asp Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 785 790 795 800 Tyr Glu Arg Lys Thr Tyr Gin Val Lys Trp Pro Asn Phe Arg Glu Gin 805 810 815 Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gin Val 820 825 830 Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val Page 884 of 3790 Ser Gin Cys Tyr Asp Val Arg Phe Tyr Asn Phe Gin Ser Ala Asn 1070 1075 1080 Page 885 of 3790 180 1345 PRT Streptococcus anginosus 180 Page 887 of 3790 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met His Ala Ile Leu Arg Arg Gin Glu Glu His Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Gin Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 450 455 460 Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 465 470 475 480 Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 485 490 495 Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Asn Glu Gin Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 565 570 575 Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 580 585 590 Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 595 600 605 Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gin Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gin Arg Leu Gin Lys Tyr 625 630 635 640 Ser Asp Ile Phe Thr Lys Ala Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Page 888 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 660 665 670 Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Tyr Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Arg Ala Gin Ile Ile Gly Asp Val Asp Asp 705 710 715 720 Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 740 745 750 Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Met Thr Asp Lys Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Leu Leu 770 775 780 Gin Asp Ser Leu Lys Asn Leu Asp Asn Pro Val Asn Ile Lys Asn Val 785 790 795 800 Glu Asn Gin Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gin 805 810 815 Asn Gly Lys Asp Met Tyr Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu 820 825 830 Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys Asp 835 840 845 Asn Ser Leu Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 850 855 860 Lys Ser Asp Asp Val Pro Ser Ile Glu Val Val His Glu Met Lys Ser 865 870 875 880 Phe Trp Ser Lys Leu Leu 885 Ser Val Lys Leu 890 Ile Thr Gin Arg Lys 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Glu Asp Lys 900 910 Page 889 of 3790 905 Page 890 of 3790 181 849 PRT Listeria ivanovii Page 891 of 3790 misc_feature (780)..(780) Xaa can be any naturally occurring amino acid 181 Leu Ile Asp Lys Asn Gly Thr Pro Gin His Ile Thr Met Ile Asp Lys 15 10 15 Met Arg Gly Lys Cys Thr Tyr Phe Pro Glu Glu Val Arg Ile Ala Lys 20 25 30 Met Ser Tyr Thr Ala Glu Leu Phe Gly Leu Leu Asn Asp Phe Asn Asn 35 40 45 Ile Tyr Phe Ala Asp Pro Glu Thr Gly Glu Lys Ile Gly Phe Thr Glu 50 55 60 Ala Asp Lys Lys Tyr Phe Ile Asp Thr Phe Ile His Asp Gin Lys Gly 65 70 75 80 Val Lys Asn Ile Thr Leu Lys Gin Ile Met Lys His Lys Asn Ile Ile 85 90 95 Asn Glu Thr Asp Ile Phe Gly Tyr Arg Ile Asn Thr Lys Asn Gly Thr 100 105 110 Pro Ile Phe Thr Glu Phe Lys Gly Leu Lys Ala Leu Lys Lys Ala Leu 115 120 125 Lys Glu Val Asp Leu Pro Asp Glu Phe Tyr Gin Asn Thr Glu Met Met 130 135 140 Asp Glu Ile Ala Asn Ile Leu Ser Ser Glu Lys Ser Phe Thr Arg Arg 145 150 155 160 Glu Glu Gin Leu Lys Glu Leu Phe Leu Ala Ala Phe Asn Asp Glu Leu 165 170 175 Glu Glu Ala Val Lys Glu Leu Ile Asn Asp Ile Thr Phe Lys Glu Phe 180 185 190 His Ser Leu Ser Lys Lys Ala Ile Met Val Ile Leu Pro Glu Leu Trp 195 200 205 Ser Thr Asn Gin Asn Gin Met Gin Leu Phe Val Gin His Lys Met Asp 210 215 220 Lys Ser Arg Leu Glu Asn Leu Gin Asn Gly Thr Lys Ile Gin Phe Asp Page 893 of 3790 Ser Ala Leu Arg Lys Arg Ala Lys Leu Asn Lys Asp Arg Asp Ala Gly 485 490 495 His Ala His His Ala Ile Asp Ala Leu Ile Val Ala Ala Ile Gly Arg 500 505 510 Leu Pro Leu Ile Lys Gin Leu Ala Glu Leu Arg Val Asn Glu Glu Gly 515 520 525 Glu Phe Ala Asp Lys Ile Thr Asp Lys Gly Leu Asp Asp Lys Thr Ala 530 535 540 Phe Asp Asp Lys Thr Leu Lys Phe Leu Arg Asn Leu Leu Asn Tyr Glu 545 550 555 560 Ser Lys Val Lys Tyr Ser His Lys Val Asp Arg Lys Pro Asn Arg Ser 565 570 575 Leu Ser Lys Gin Thr Leu Tyr Ser Thr Arg Glu Lys Asp Gly Glu Lys 580 585 590 Tyr Ile Ile Gly Lys Val Lys Asn Ile Tyr Thr Leu Asp Lys Ala Gly 595 600 605 Tyr Ala Ala Leu Lys Lys Arg Ile Asp Lys Asn Pro Glu Asp Phe Leu 610 615 620 Met Ala Gin His Asn Pro Lys Thr Trp Glu Glu Ile Ile Lys Ile Met 625 630 635 640 Glu Val Tyr Ser Lys Ala Asp Asn Pro Phe Lys Glu Phe Tyr Asp Glu 645 650 655 His Gly Phe Ile Met Lys Asp Gly Lys Val Pro Val Lys Ser Leu Arg 660 665 670 Tyr His Asp Lys Lys Leu Gly Ile His Val Pro Leu Thr His Lys Tyr 675 680 685 Glu Asn Thr Arg His Asp Val Val Leu Leu Lys Arg Asn Ser Leu Arg 690 695 700 Val Asp Ile Tyr Met Asn Lys Glu Gly Val Tyr Lys Tyr Gin Gly Val 705 710 715 720 Pro Tyr Asn Trp Phe Asn Gin Lys Gly Asp Lys Tyr Ile Leu Asp Met 725 730 735 Page 894 of 3790 Page 895 of 3790 Ala Ile Gly Trp Asp Arg Thr Glu Ala Val Thr Tyr Gly Lys Phe Leu 100 105 110 Asn His Ala Glu Pro Lys Leu Ala Trp Glu Glu Leu Gly Asn Gly Lys 115 120 125 Arg Arg Phe Leu Phe Met Asp Ser Phe His Glu Met Val Ala Asp Phe 130 135 140 Ala Arg Cys Gin Pro Ala Leu Val Ala Asp Gly Lys Lys Ile Pro Leu 145 150 155 160 Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gin Ala Ile 165 170 175 Thr Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg 180 185 190 Gly Tyr Tyr Gin Leu Arg Gly Glu Glu Glu Glu Glu Asn Pro Thr Lys 195 200 205 Gin Glu Glu Tyr Tyr Glu Leu Lys Val Val Ser Val Glu Ala Thr Asp 210 215 220 Ser Arg Lys Gly Asn Asp Thr Trp Tyr Asn Val His Leu Glu Asn Gly 225 230 235 240 Trp Ile Tyr Arg Arg Ser Ser Lys Ile Ser Leu Asp Asp Trp Val Gly 245 250 255 Lys Val Lys Gin Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Ala 260 265 270 Thr Leu Lys Thr Asp Lys Glu Gly Tyr Val Lys Arg Ser Phe Arg Ala 275 280 285 Pro Asn Glu Asn Asp Trp Gly Leu Arg Lys Lys Arg Thr Glu Thr Leu 290 295 300 Leu Glu Met Ser Gly Lys Thr Val Gly Ala Phe Ile Tyr Asp His Leu 305 310 315 320 Leu Gin Glu Pro Ala Asp Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 325 330 335 Glu Arg His Tyr Tyr Lys Ala Glu Leu Glu Ala Ile Leu Ala Glu Gin 340 345 350 Page 896 of 3790 Cys Lys Tyr His Ile Glu Leu Arg Asp Lys Glu Met Leu Glu Ala Cys 355 360 365 Ala Arg Glu Leu Tyr Leu Asn Asn Leu Pro His Gin Arg Ser Leu Met 370 375 380 Lys Lys Asp Met Thr Tyr Leu Leu Leu Tyr Asp Leu Ile Phe Tyr Gin 385 390 395 400 Arg Pro Leu Lys Ser Lys Lys Ala Leu Ile Ala Asn Cys Pro Tyr Glu 405 410 415 Tyr Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gin Asn 420 425 430 Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Phe Gin Glu Phe Arg Leu 435 440 445 Trp Gin Phe Val Leu Asn Leu Arg Leu Phe Asp Arg Val Glu Asp Lys 450 455 460 Glu Val Thr Ala Asn Tyr Leu Pro Thr Ala Asp Asp His Ala Arg Leu 465 470 475 480 Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gin Glu Thr Leu Leu 485 490 495 Lys Asp Tyr Phe Lys Leu Lys Lys Val Lys Ile Gly Asn Glu Lys Glu 500 505 510 Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 515 520 525 Cys Asn Glu Thr Arg Tyr Glu Leu Leu Met Ala Leu Asp Arg Ala Gly 530 535 540 Ile Glu His Lys Trp Leu Asp Asp Asn Asn Leu Glu Tyr Arg Leu Trp 545 550 555 560 His Leu Leu Tyr Ser Val Glu Val Lys Ser Glu Ser Glu Thr Ala Leu 565 570 575 Arg Lys Leu Lys Asn Asp Asp Ala Phe Val Asn Ser Phe Leu Lys Val 580 585 590 Lys Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys Page 897 of 3790 595 600 605 Arg Leu Leu Ala Val Met Arg Lys Gly Phe Leu Trp Asn Glu Gin Asp 610 615 620 Ile Cys Asp Glu Thr Arg Lys Arg Ile Glu Ile Ile Ile Lys Gly Asp 625 630 635 640 Val Asp Glu Lys Val Lys Glu Arg Met Gly His Ala Ala Tyr Ser Phe 645 650 655 Asp Arg Val Ser Asp Phe Gin Gly Leu Pro Glu Trp Leu Ala Cys Tyr 660 665 670 Val Val Tyr Gly Arg His Ser Glu Ala Met Asp Ile Gin His Trp Asp 675 680 685 Ser Pro Glu Arg Leu Met Ala Tyr Ile Asn Asn Phe Lys Gin Tyr Ser 690 695 700 Leu Arg Asn Pro Ile Val Glu Gin Cys Ile Leu Glu Thr Leu Arg Thr 705 710 715 720 Val His Asp Ile Trp Lys Glu Thr Gly Gin Ile Asp Glu Ile His Val 725 730 735 Glu Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Glu Arg Ala Arg Arg 740 745 750 Thr Gin Asn Val Leu Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser 755 760 765 Leu Leu Ile Glu Leu Lys Asn Asp Thr Asp Ile Cys Asn Val His Pro 770 775 780 Tyr Ser Pro Met Gin Gin Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala 785 790 795 800 Leu Gin Glu Leu Asn Arg Glu Asp Glu Asp Phe Glu Glu Ile Ser Lys 805 810 815 Ile Ser Gin Met Ser Gin Pro Ser Gly Lys Glu Leu Asn Arg Tyr Lys 820 825 830 Leu Trp Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Ala Ile 835 840 845 Page 898 of 3790 Page 899 of 3790 Page 900 of 3790 183 1330 PRT Enterococcus italicus 183 Met Lys Asn Asp Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Ile Ser Lys Lys Met 20 25 30 Asn Val Phe Gly Asn Thr Glu Lys Lys Ser Ile Lys Lys Asn Phe Trp 35 40 45 Gly Val Arg Leu Phe Glu Ser Gly Gin Thr Ala Gin Glu Ala Arg Met 50 55 60 Lys Arg Thr Ser Arg Arg Arg Ile Ala Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Gin Pro Glu Met Asn His Leu Asp Asn Asn 85 90 95 Page 901 of 3790 Phe Phe Tyr Arg Leu Asn Glu Ser Phe Leu Val Ala Asp Asp Ala Lys 100 105 110 Tyr Asp Lys His Pro Ile Phe Gly Thr Leu Asp Glu Glu Ile His Phe 115 120 125 His Glu Gin Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 130 135 140 Gly Asp Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Ile Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly Asn Phe Leu Ile Glu Gly Glu Leu Asn Thr 165 170 175 Glu Asn Asn Ser Val Ile Glu Leu Ser Lys Val Phe Val Gin Leu Tyr 180 185 190 Asn Gin Thr Leu Ser Glu Leu Glu Gly Phe Gin Phe Ile Asp Glu Ser 195 200 205 Ile Asp Phe Ser Glu Val Leu Thr Gin Gin Leu Ser Lys Ser Glu Arg 210 215 220 Ala Asp Asn Val Leu Lys Leu Phe Pro Asp Glu Lys Gly Thr Gly Ile 225 230 235 240 Phe Ala Gin Phe Ile Lys Leu Ile Val Gly Asn Gin Gly Asn Phe Lys 245 250 255 Lys Val Phe Gin Leu Glu Glu Asp Gin Lys Leu Gin Leu Ser Thr Asp 260 265 270 Asp Tyr Glu Glu Asn Ile Glu Asn Leu Leu Ala Ile Ile Gly Asp Glu 275 280 285 Tyr Gly Asp Ile Phe Val Ala Ala Gin Asn Leu Tyr Gin Ala Ile Leu 290 295 300 Leu Ala Gly Ile Leu Thr Ser Thr Glu Lys Thr Arg Ala Lys Leu Ser 305 310 315 320 Ala Ser Met Ile Gin Arg Tyr Glu Glu His Ala Lys Asp Leu Lys Leu 325 330 335 Leu Lys Arg Phe Val Lys Glu His Ile Pro Asp Lys Tyr Ala Glu Ile Page 903 of 3790 Gly Thr Tyr Leu Asp Leu Lys Lys Phe Asp Glu Leu His Pro Tyr Leu 595 600 605 Asp Asp Glu Lys Tyr Gin Asp Thr Leu Glu Glu Val Ile Lys Val Leu 610 615 620 Thr Val Phe Glu Asp Arg Ser Met Ile Gin Asn Gin Leu Glu Gin Leu 625 630 635 640 Pro Leu Asn Leu Ser Thr Lys Thr Ile Lys Ala Leu Ser Arg Arg Lys 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Arg Leu Ile Asp Gly Ile His 660 665 670 Asp Lys Asn Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Glu Asp Glu 675 680 685 Ser Asp Ser Tyr Ile Val Asn Arg Asn Phe Met Gin Leu Ile Asn Asp 690 695 700 Asp His Leu Ser Phe Lys Lys Ile Ile Glu Asp Ser Gin Pro Tyr Lys 705 710 715 720 Glu Gin Gin Ser Ala Glu Glu Ile Val Ser Glu Leu Ser Gly Ser Pro 725 730 735 Ala Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu 740 745 750 Val Ala Ile Met Gly Tyr Lys Pro Lys Asn Ile Val Val Glu Met Ala 755 760 765 Arg Glu Asn Gin Thr Thr Gly Arg Gly Lys Gin Asn Ser Lys Pro Arg 770 775 780 Leu Lys Gly Ile Glu Asn Gly Leu Lys Glu Phe Ser Asp Ser Val Leu 785 790 795 800 Lys Gly Ser Ser Ile Asp Asn Lys Gin Leu Gin Asn Asp Arg Leu Tyr 805 810 815 Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly His Glu Leu 820 825 830 Asp Ile Asp His Leu Ser Thr Tyr Asp Ile Asp His Ile Ile Pro Gin 835 840 845 Page 904 of 3790 Page 905 of 3790 Arg Val Arg Leu Thr Glu Val Page 906 of 3790 Ala Thr Pro Ala Glu Val Leu Val Asp Leu Met Gly Arg Gin Lys Ile Page 909 of 3790 Gin Ser Lys Gly Ala Gin Thr Gin Val Ser Val Tyr Arg Gly Ala Val 725 730 735 Thr Ala Gin Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 740 745 750 Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met 755 760 765 Asp Ala Ala Thr Ile Ala Leu Met Thr Pro Gly Ile Ser Thr Thr Leu 770 775 780 Ser Glu Lys Asn Asn Leu Arg Asp Ala Gin Lys Phe Thr Gly Gin Ser 785 790 795 800 Glu Thr Trp Lys Asp Tyr Cys Gly Arg Thr Glu Thr Ala Arg Glu His 805 810 815 Phe Ala Val Trp Lys Ser Asn Met Glu Arg Leu Thr Asp Leu Phe Asn 820 825 830 Asp Lys Leu Glu Asn Asp Ala Ile Pro Val Val Gin Pro Leu Arg Leu 835 840 845 Arg Leu Ser Asp Ser Lys Ala His Asp Asp Gly Ile Gly Lys Leu Asp 850 855 860 Ser Lys Lys Leu Gly Ser Val Trp Ser Leu Ala Asp Ile Asp Arg Ala 865 870 875 880 Ala Thr Pro Gin Ile Trp Thr Ala Leu Thr Arg Cys Asp Asp Phe Asp 885 890 895 Pro Thr Lys Gly Leu Pro Glu Asn Ala Asn Arg Val Ile Arg Ala Gin 900 905 910 Gly Val Lys Tyr Glu Ser Glu Asp Asn Ile Pro Val Phe Pro Ser Asn 915 920 925 Val Ala Ala Ile Ala Val Arg Asp Gly Tyr Ala Glu Ile Gly Ser Thr 930 935 940 Ile His His Ala Arg Ile Tyr Arg Ile Asp Asp Gly Lys Lys Ile Phe 945 950 955 960 Tyr Ser Met Ile Arg Val Phe Ala Val Asp Leu Leu Lys His Gin Ala 965 970 975 Page 910 of 3790 Glu Asp Leu Phe Thr Val Lys Leu Pro Pro Ser Ala Ile Ser Ile Arg 980 985 990 Thr Cys Glu Asp Ser Leu Arg Arg Ala Leu Ser Asn Gly Thr Ala Glu 995 1000 1005 185 1054 PRT Staphylococcus lugdunensis 185 Met Asn Gin Lys Phe Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 15 10 15 Gly Tyr Gly Leu Ile Asp Tyr Glu Thr Lys Asn Ile Ile Asp Ala Gly 20 25 30 Val Arg Leu Phe Pro Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 35 40 45 Ser Lys Arg Gly Ser Arg Arg Leu Lys Arg Arg Arg Ile His Arg Leu 50 55 60 Page 911 of 3790 Glu Arg Val Lys Lys Leu Leu Glu Asp Tyr Asn Leu Leu Asp Gin Ser 65 70 75 80 Gin Ile Pro Gin Ser Thr Asn Pro Tyr Ala Ile Arg Val Lys Gly Leu 85 90 95 Ser Glu Ala Leu Ser Lys Asp Glu Leu Val Ile Ala Leu Leu His Ile 100 105 110 Ala Lys Arg Arg Gly Ile His Lys Ile Asp Val Ile Asp Ser Asn Asp 115 120 125 Asp Val Gly Asn Glu Leu Ser Thr Lys Glu Gin Leu Asn Lys Asn Ser 130 135 140 Lys Leu Leu Lys Asp Lys Phe Val Cys Gin Ile Gin Leu Glu Arg Met 145 150 155 160 Asn Glu Gly Gin Val Arg Gly Glu Lys Asn Arg Phe Lys Thr Ala Asp 165 170 175 Ile Ile Lys Glu Ile Ile Gin Leu Leu Asn Val Gin Lys Asn Phe His 180 185 190 Gin Leu Asp Glu Asn Phe Ile Asn Lys Tyr Ile Glu Leu Val Glu Met 195 200 205 Arg Arg Glu Tyr Phe Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 210 215 220 Glu Gly Asp Pro Lys Ala Trp Tyr Glu Thr Leu Met Gly His Cys Thr 225 230 235 240 Tyr Phe Pro Asp Glu Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 245 250 255 Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Gin Arg Asp 260 265 270 Gly Leu Ser Lys Leu Glu Tyr His Glu Lys Tyr His Ile Ile Glu Asn 275 280 285 Val Phe Lys Gin Lys Lys Lys Pro Thr Leu Lys Gin Ile Ala Asn Glu 290 295 300 Ile Asn Val Asn Pro Glu Asp Ile Lys Gly Tyr Arg Ile Thr Lys Ser Page 913 of 3790 Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Tyr His Asn Lys Val Leu 565 570 575 Val Lys Gin Ser Glu Asn Ser Lys Lys Ser Asn Leu Thr Pro Tyr Gin 580 585 590 Tyr Phe Asn Ser Gly Lys Ser Lys Leu Ser Tyr Asn Gin Phe Lys Gin 595 600 605 His Ile Leu Asn Leu Ser Lys Ser Gin Asp Arg Ile Ser Lys Lys Lys 610 615 620 Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Lys Phe Glu Val Gin 625 630 635 640 Lys Glu Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg 645 650 655 Glu Leu Thr Asn Tyr Leu Lys Ala Tyr Phe Ser Ala Asn Asn Met Asn 660 665 670 Val Lys Val Lys Thr Ile Asn Gly Ser Phe Thr Asp Tyr Leu Arg Lys 675 680 685 Val Trp Lys Phe Lys Lys Glu Arg Asn His Gly Tyr Lys His His Ala 690 695 700 Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Leu Phe Lys Glu Asn 705 710 715 720 Lys Lys Leu Lys Ala Val Asn Ser Val Leu Glu Lys Pro Glu Ile Glu 725 730 735 Ser Lys Gin Leu Asp Ile Gin Val Asp Ser Glu Asp Asn Tyr Ser Glu 740 745 750 Met Phe Ile Ile Pro Lys Gin Val Gin Asp Ile Lys Asp Phe Arg Asn 755 760 765 Phe Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Gin Leu Ile 770 775 780 Asn Asp Thr Leu Tyr Ser Thr Arg Lys Lys Asp Asn Ser Thr Tyr Ile 785 790 795 800 Val Gin Thr Ile Lys Asp Ile Tyr Ala Lys Asp Asn Thr Thr Leu Lys 805 810 815 Page 914 of 3790 Asn Page 915 of 3790 186 586 PRT Pseudoramibacter alactolyticus 186 Met Thr Tyr Tyr Leu Gly Leu Asp 1 5 Met Gly Thr Gly Ser Val Gly Trp 10 15 Ala Ala Thr Asp Lys Asn Tyr Lys 20 Leu Ile Arg Ala Lys Gly Lys Asp 25 30 Leu Trp Gly Val Arg Leu Phe Gin 35 40 Thr Ala Lys Thr Ala Ala Glu Arg 45 Arg Ser His Arg Val Ala Arg Leu 50 55 Arg Arg Gin Arg Glu Lys Val Arg 60 Ile Gly Tyr Leu Lys Thr Ile Phe 65 70 Ser Asp Ala Ile Asn Lys Val Asp 75 80 Pro Gly Phe Phe Gin Arg Leu Asp 85 Asp Ser Phe Phe Tyr Ala Glu Asp 90 95 Lys Asn Ile Asn Gin Pro Tyr Ala 100 Leu Phe Ala Asp Thr Gly Tyr Thr 105 110 Asp Val Asp Tyr Tyr Arg Asp Tyr 115 120 Pro Thr Ile Phe His Leu Arg Ser 125 Thr Leu Ile His Asp Thr Ser Pro 130 135 Lys Asp Val Arg Leu Val Tyr Leu 140 Ala Val Leu Asn Met Phe Lys His 145 150 Arg Gly His Phe Leu Ala Ser Asn 155 160 Leu Ser Glu Asn Gly Val Asp Asp 165 Phe Gly Asp Ile Tyr Gin Gin Trp 170 175 Cys Lys Ser Val Pro Lys Pro Val 180 Gin Ile Ser Asp Pro Glu Ala Lys 185 190 Thr Glu Lys Ile Glu Asn Ile Leu 195 200 Ser Lys Ala Gly Ile Ser Asn Thr 205 Arg Arg Leu Glu Ala Leu Leu Glu 210 215 Val Phe Gly Ile Lys Arg Arg Asp 220 Page 916 of 3790 Ala Phe Ala Glu Val Leu Lys Leu Trp Cys Gly Leu Lys Gly Asn Leu 225 230 235 240 Ser Lys Ile Trp Ser Glu Thr Asp Phe Ser Asp Leu Asp Asn Thr Lys 245 250 255 Pro Ala Leu Ser Phe Lys Asp Ser Asn Leu Asp Met Val Leu Ser Gin 260 265 270 Leu Glu Glu Ile Leu Pro Asp Glu Asp Tyr Ser Trp Leu Met Leu Thr 275 280 285 Lys Gin Ile Tyr Asp Trp Ser Leu Leu Ser Gly Met Met Lys Asp Ala 290 295 300 Ser Gly Lys Ser Tyr Asp Tyr Leu Ser Asp Ala Arg Val Ala Ser Tyr 305 310 315 320 Gin Lys His Ser Glu Asp Leu Lys Thr Leu Lys Arg Phe Tyr His Asp 325 330 335 Asn His Leu Ser Ala Ala Tyr Asp Gin Met Phe Arg Val Met Gly Lys 340 345 350 Asp Asn Tyr Ser Ala Tyr Ala Gly Ser Val Gin Ser Lys Lys Glu Val 355 360 365 Val Arg Arg Gly Ala Ser Cys Gly Ile Glu Glu Leu Tyr Lys Arg Ile 370 375 380 Lys Lys Asp Leu Lys Pro Val Pro Asp Cys Glu Thr Lys Gin Ile Ile 385 390 395 400 Leu Glu Asn Ile Glu Arg Gly Thr Phe Leu Pro Lys Gin Leu Thr Arg 405 410 415 Asp Asn Gly Val Ile Pro Asn Gin Ile His Val His Glu Leu Lys Ala 420 425 430 Ile Leu Lys Asn Ala Glu Asn Tyr Leu Pro Phe Leu Lys Glu Gly Ser 435 440 445 Glu Leu Thr Asn Ser Glu Lys Ile Leu Gin Leu Phe Gin Phe Gin Ile 450 455 460 Pro Tyr Tyr Val Gly Pro Leu Tyr Ser Asp Glu Asn Asn Tyr Ala Trp 580 585 187 1385 PRT Gemella morbillorum 187 Phe Glu Asp Lys Ser Leu Met Asn Glu Tyr Ile Leu Phe Asn Asp Lys Page 920 of 3790 Asp Phe Lys Lys Ile Leu Ala Asp Lys Phe Asp Lys Glu Arg Val Glu 610 615 620 Asn Ile Ile Leu Trp Ile Thr Leu Tyr Gly Glu Ser Arg Lys Leu Ile 625 630 635 640 Lys Glu Lys Ile Thr Lys Val Tyr Gly Asp Phe Tyr Thr Val Asp Glu 645 650 655 Ile Glu Lys Met Ser Arg Leu Thr Tyr Lys Asp Trp Gly Ile Leu Ser 660 665 670 Arg Lys Leu Leu Thr Glu Leu Val Ser Glu Lys Leu Tyr Asn Glu Glu 675 680 685 Thr Gly Glu Cys Leu Asn Ile Ile Gly Ala Met Arg Gin Gly Thr Ile 690 695 700 Leu Phe Met Glu Leu Leu Ala Asp Lys Phe Asp Tyr Met Ser Gin Ile 705 710 715 720 Lys Asn His Asn Lys Glu Asn Lys Asp Asp Ile Thr Glu Ile Thr Pro 725 730 735 Asp Ile Leu Glu Asn Leu His Ala Ser Pro Ala Val Lys Arg Ser Ile 740 745 750 Trp Gin Thr Val Arg Ile Val Glu Glu Leu Lys Thr Ile Ile Gly Cys 755 760 765 Val Pro Thr Lys Ile Phe Ile Glu Thr Thr Lys Arg Asn Asn Ala Pro 770 775 780 Tyr Lys Val Pro Thr Leu Asn Arg Asn Asp Leu Val Thr Lys Tyr Lys 785 790 795 800 Thr Ile Arg Glu His Glu Ile Phe Glu Leu Glu Lys Glu Leu Lys Asn 805 810 815 Thr Leu Asp Phe Thr Leu Asn Lys Asn Arg Leu Ile Asn Glu Glu Pro 820 825 830 Ser Lys Leu Lys Ala Thr Lys Leu Tyr Leu Tyr Tyr Thr Gin Leu Gly 835 840 845 Arg Cys Met Tyr Thr Gly Lys Lys Ile Asp Leu Gly Glu Leu Phe Asp 850 855 860 Page 921 of 3790 Gin Lys Gly Ala Leu Tyr Asp Ala Thr Leu Tyr Lys Ala Lys Val Ile Leu 1385 188 1029 PRT Alicycliphilus denitrificans 188 Page 924 of 3790 Glu Gin Gly Ser Arg Thr Val Gly Glu Tyr Leu Trp Thr Arg Leu Gin 165 170 175 Gin Gly Gin Gly Val Arg Ala Arg Tyr Arg Glu Lys Pro Tyr Thr Thr 180 185 190 Glu Glu Gly Lys Lys Arg Ile Asp Lys Ser Tyr Asp Leu Tyr Ile Asp 195 200 205 Arg Ala Met Ile Glu Gin Glu Phe Asp Ala Leu Trp Ala Ala Gin Ala 210 215 220 Ala Phe Asn Pro Thr Leu Phe His Glu Ala Ala Arg Ala Asp Leu Lys 225 230 235 240 Asp Thr Leu Leu His Gin Arg Pro Leu Arg Pro Val Lys Pro Gly Arg 245 250 255 Cys Thr Leu Leu Pro Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser 260 265 270 Thr Gin Arg Phe Arg Ile His Gin Glu Val Asn His Leu Arg Leu Leu 275 280 285 Asp Glu Asn Leu Arg Glu Val Ala Leu Thr Leu Ala Gin Arg Asp Ala 290 295 300 Val Val Thr Ala Leu Glu Thr Lys Ala Lys Leu Ser Phe Glu Gin Ile 305 310 315 320 Arg Lys Leu Leu Lys Leu Ser Gly Ser Val Gin Phe Asn Leu Glu Asp 325 330 335 Ala Lys Arg Thr Glu Leu Lys Gly Asn Ala Thr Ser Ala Ala Leu Ala 340 345 350 Arg Lys Glu Leu Phe Gly Ala Ala Trp Ser Gly Phe Asp Glu Ala Leu 355 360 365 Gin Asp Glu Ile Val Trp Gin Leu Val Thr Glu Glu Gly Glu Gly Ala 370 375 380 Leu Ile Ala Trp Leu Gin Thr His Thr Gly Val Asp Glu Ala Arg Ala 385 390 395 400 Gin Ala Ile Val Asp Val Ser Leu Pro Glu Gly Tyr Gly Asn Leu Ser 405 410 415 Page 925 of 3790 Arg Lys Ala Leu Ala Arg Ile Val Pro Ala Leu Arg Ala Ala Val Ile 420 425 430 Thr Tyr Asp Lys Ala Val Gin Ala Ala Gly Phe Asp His His Ser Gin 435 440 445 Leu Gly Phe Glu Tyr Asp Ala Ser Glu Val Glu Asp Leu Val His Pro 450 455 460 Glu Thr Gly Glu Ile Arg Ser Val Phe Lys Gin Leu Pro Tyr Tyr Gly 465 470 475 480 Lys Ala Leu Gin Arg His Val Ala Phe Gly Ser Gly Lys Pro Glu Asp 485 490 495 Pro Asp Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 500 505 510 Gly Leu Asn Gin Val Arg Met Val Val Asn Ala Leu Ile Arg Arg Tyr 515 520 525 Gly Arg Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gin 530 535 540 Ser Arg Glu Gin Lys Val Glu Ala Gin Arg Arg Gin Ala Asp Asn Gin 545 550 555 560 Arg Arg Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile 565 570 575 Gly Glu Glu Arg Val Arg Gly Ser Asp Ile Gin Lys Trp Ile Cys Trp 580 585 590 Glu Glu Leu Ser Phe Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly 595 600 605 Val Gin Ile Ser Ala Ala Met Leu Leu Ser Asp Glu Val Glu Val Glu 610 615 620 His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Leu Asn Asn Arg 625 630 635 640 Thr Val Ala Met Arg Gin Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro 645 650 655 Trp Asp Ala Arg Ala Glu Phe Glu Ala Gin Gly Trp Ser Tyr Glu Asp 660 665 670 Page 926 of 3790 Ile Leu Gin Arg Ala Glu Arg Met Pro Leu Arg Lys Arg Tyr Arg Phe 675 680 685 Ala Pro Asp Gly Tyr Glu Arg Trp Leu Gly Asp Asp Lys Asp Phe Leu 690 695 700 Ala Arg Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu 705 710 715 720 Tyr Leu Arg Leu Val Cys Pro Gly Thr Arg Val Ile Pro Gly Gin Leu 725 730 735 Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 740 745 750 Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 755 760 765 Cys Val Ile Gly Val Thr Asp Gin Gly Leu Met Gin Arg Phe Ala Thr 770 775 780 Ala Ser Ala Gin Ala Arg Gly Asp Gly Leu Thr Arg Leu Val Asp Gly 785 790 795 800 Met Pro Met Pro Trp Pro Thr Tyr Arg Asp His Val Glu Arg Ala Val 805 810 815 Arg His Ile Trp Val Ser His Arg Pro Asp His Gly Phe Glu Gly Ala 820 825 830 Met Met Glu Glu Thr Ser Tyr Gly Ile Arg Lys Asp Gly Ser Ile Lys 835 840 845 Gin Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Ile Ser Asn Leu 850 855 860 Ile Arg Ile His Glu Ala Thr Gin Pro Leu Arg His Gly Val Ser Ala 865 870 875 880 Asp Gly Gin Pro Leu Ala Tyr Lys Gly Tyr Val Gly Gly Ser Asn Tyr 885 890 895 Cys Ile Glu Ile Thr Val Asn Asp Lys Gly Lys Trp Glu Gly Glu Val 900 905 910 Ile Ser Thr Phe Arg Ala Tyr Gly Val Val Arg Ala Gly Gly Met Gly Page 927 of 3790 Ala Lys Thr Arg Arg Val Thr Ile Ser Pro Ile Gly Glu Val Arg Glu Trp Lys Arg Gly Arg Glu Ala Leu Ser Gly Leu Leu Lys Arg Arg Page 930 of 3790 Asn Pro Phe Ser Leu Ala Gin Phe Tyr Thr Leu Ile Glu Thr Glu Val 610 615 620 Ser Gly Phe Ser Ala Thr Thr Leu Ala Val His Leu Glu Asn Ala Trp 625 630 635 640 Arg Met Thr Ile Lys Asp Ala Val Ile Asn Gly Glu Thr Val Arg Ala 645 650 655 Ala Gin Cys Ser Arg Leu Pro Ala Glu Thr Ala Arg Pro Phe Asp Gly 660 665 670 Leu Val Arg Arg Leu Val Asp Arg Gin Ala Trp Glu Ile Ala Lys Arg 675 680 685 Val Ser Thr Asp Ile Gin Ser Lys Val Asp Phe Ser Asn Gly Ile Val 690 695 700 Asp Val Ser Ile Phe Val Glu Glu Asn Lys Phe Glu Phe Ser Ala Ser 705 710 715 720 Val Ala Asp Leu Lys Lys Asn Lys Arg Val Lys Asp Lys Met Leu Ser 725 730 735 Glu Ala Glu Lys Leu Glu Thr Arg Trp Leu Ile Lys Asn Glu Arg Ile 740 745 750 Lys Lys Ala Ser Arg Gly Thr Cys Pro Tyr Thr Gly Asp Arg Leu Ala 755 760 765 Glu Gly Gly Glu Ile Asp His Ile Leu Pro Arg Ser Leu Ile Lys Asp 770 775 780 Ala Arg Gly Ile Val Phe Asn Ala Glu Pro Asn Leu Ile Tyr Ala Ser 785 790 795 800 Ser Arg Gly Asn Gin Leu Lys Lys Asn Gin Arg Tyr Ser Leu Ser Asp 805 810 815 Leu Lys Ala Asn Tyr Arg Asn Glu Ile Phe Lys Thr Ser Asn Ile Ala 820 825 830 Ala Ile Thr Ala Glu Ile Glu Asp Val Val Thr Lys Leu Gin Gin Thr 835 840 845 His Arg Leu Lys Phe Phe Asp Leu Leu Asn Glu His Glu Gin Asp Cys 850 855 860 Page 931 of 3790 His Ala 1085 Thr Tyr Arg Ile Leu 1090 Lys Lys Pro Ala Tyr 1095 Glu Phe Leu Ala Lys Ala Ala Leu Gin Pro Leu Ser Ala Glu Glu Lys Arg Leu Page 933 of 3790 1415 1420 190 1132 PRT Nitratifractor salsuginis 190 Met Lys Lys Ile Leu Gly Val Asp Leu Gly Ile Thr Ser Phe Gly Tyr 15 10 15 Ala Ile Leu Gin Glu Thr Gly Lys Asp Leu Tyr Arg Cys Leu Asp Asn 20 25 30 Ser Val Val Met Arg Asn Asn Pro Tyr Asp Glu Lys Ser Gly Glu Ser 35 40 45 Ser Gin Ser Ile Arg Ser Thr Gin Lys Ser Met Arg Arg Leu Ile Glu 50 55 60 Lys Arg Lys Lys Arg Ile Arg Cys Val Ala Gin Thr Met Glu Arg Tyr 65 70 75 80 Gly Ile Leu Asp Tyr Ser Glu Thr Met Lys Ile Asn Asp Pro Lys Asn 85 90 95 Asn Pro Ile Lys Asn Arg Trp Gin Leu Arg Ala Val Asp Ala Trp Lys 100 105 110 Arg Pro Leu Ser Pro Gin Glu Leu Phe Ala Ile Phe Ala His Met Ala 115 120 125 Page 935 of 3790 Lys His Pro Asp Ala Leu Gin Ile Phe Arg Glu Leu Ala Glu Ile Leu 385 390 395 400 Gin Arg Ser Lys Thr Pro Gin Glu Ala Leu Asp Arg Leu Arg Ala Leu 405 410 415 Met Ala Gly Lys Gly Ile Asp Thr Asp Asp Arg Glu Leu Leu Glu Leu 420 425 430 Phe Lys Asn Lys Arg Ser Gly Thr Arg Glu Leu Ser His Arg Tyr Ile 435 440 445 Leu Glu Ala Leu Pro Leu Phe Leu Glu Gly Tyr Asp Glu Lys Glu Val 450 455 460 Gin Arg Ile Leu Gly Phe Asp Asp Arg Glu Asp Tyr Ser Arg Tyr Pro 465 470 475 480 Lys Ser Leu Arg His Leu His Leu Arg Glu Gly Asn Leu Phe Glu Lys 485 490 495 Glu Glu Asn Pro Ile Asn Asn His Ala Val Lys Ser Leu Ala Ser Trp 500 505 510 Ala Leu Gly Leu Ile Ala Asp Leu Ser Trp Arg Tyr Gly Pro Phe Asp 515 520 525 Glu Ile Ile Leu Glu Thr Thr Arg Asp Ala Leu Pro Glu Lys Ile Arg 530 535 540 Lys Glu Ile Asp Lys Ala Met Arg Glu Arg Glu Lys Ala Leu Asp Lys 545 550 555 560 Ile Ile Gly Lys Tyr Lys Lys Glu Phe Pro Ser Ile Asp Lys Arg Leu 565 570 575 Ala Arg Lys Ile Gin Leu Trp Glu Arg Gin Lys Gly Leu Asp Leu Tyr 580 585 590 Ser Gly Lys Val Ile Asn Leu Ser Gin Leu Leu Asp Gly Ser Ala Asp 595 600 605 Ile Glu His Ile Val Pro Gin Ser Leu Gly Gly Leu Ser Thr Asp Tyr 610 615 620 Asn Thr Ile Val Thr Leu Lys Ser Val Asn Ala Ala Lys Gly Asn Arg 625 630 635 640 Page 936 of 3790 Leu Pro Gly Asp Trp Leu Ala Gly Asn Pro Asp Tyr Arg Glu Arg Ile 645 650 655 Gly Met Leu Ser Glu Lys Gly Leu Ile Asp Trp Lys Lys Arg Lys Asn 660 665 670 Leu Leu Ala Gin Ser Leu Asp Glu Ile Tyr Thr Glu Asn Thr His Ser 675 680 685 Lys Gly Ile Arg Ala Thr Ser Tyr Leu Glu Ala Leu Val Ala Gin Val 690 695 700 Leu Lys Arg Tyr Tyr Pro Phe Pro Asp Pro Glu Leu Arg Lys Asn Gly 705 710 715 720 Ile Gly Val Arg Met Ile Pro Gly Lys Val Thr Ser Lys Thr Arg Ser 725 730 735 Leu Leu Gly Ile Lys Ser Lys Ser Arg Glu Thr Asn Phe His His Ala 740 745 750 Glu Asp Ala Leu Ile Leu Ser Thr Leu Thr Arg Gly Trp Gin Asn Arg 755 760 765 Leu His Arg Met Leu Arg Asp Asn Tyr Gly Lys Ser Glu Ala Glu Leu 770 775 780 Lys Glu Leu Trp Lys Lys Tyr Met Pro His Ile Glu Gly Leu Thr Leu 785 790 795 800 Ala Asp Tyr Ile Asp Glu Ala Phe Arg Arg Phe Met Ser Lys Gly Glu 805 810 815 Glu Ser Leu Phe Tyr Arg Asp Met Phe Asp Thr Ile Arg Ser Ile Ser 820 825 830 Tyr Trp Val Asp Lys Lys Pro Leu Ser Ala Ser Ser His Lys Glu Thr 835 840 845 Val Tyr Ser Ser Arg His Glu Val Pro Thr Leu Arg Lys Asn Ile Leu 850 855 860 Glu Ala Phe Asp Ser Leu Asn Val Ile Lys Asp Arg His Lys Leu Thr 865 870 875 880 Thr Glu Glu Phe Met Lys Arg Tyr Asp Lys Glu Ile Arg Gin Lys Leu 885 895 Page 937 of 3790 890 Ile Glu Trp Phe Lys Glu Glu Ser Gly Tyr Gly Arg Val Glu Asp 1115 1120 1125 Page 938 of 3790 180 185 190 Tyr Leu Asn Glu Asn Asp Ile Glu Phe Asn Ile Glu Asn Lys Lys Glu 195 200 205 Page 939 of 3790 Phe Ile Asn Val Leu Ser Asp Lys His Leu Thr Lys Lys Glu Lys Lys 210 215 220 Ile Ser Leu Lys Lys Leu Tyr Gly Asp Ile Thr Asp Ser Glu Asn Ile 225 230 235 240 Asn Ile Ser Val Leu Ile Glu Met Leu Ser Gly Ser Ser Ile Ser Leu 245 250 255 Ser Asn Leu Phe Lys Asp Ile Glu Phe Asp Gly Lys Gin Asn Leu Ser 260 265 270 Leu Asp Ser Asp Ile Glu Glu Thr Leu Asn Asp Val Val Asp Ile Leu 275 280 285 Gly Asp Asn Ile Asp Leu Leu Ile His Ala Lys Glu Val Tyr Asp Ile 290 295 300 Ala Val Leu Thr Ser Ser Leu Gly Lys His Lys Tyr Leu Cys Asp Ala 305 310 315 320 Lys Val Glu Leu Phe Glu Lys Asn Lys Lys Asp Leu Met Ile Leu Lys 325 330 335 Lys Tyr Ile Lys Lys Asn His Pro Glu Asp Tyr Lys Lys Ile Phe Ser 340 345 350 Ser Pro Thr Glu Lys Lys Asn Tyr Ala Ala Tyr Ser Gin Thr Asn Ser 355 360 365 Lys Asn Val Cys Ser Gin Glu Glu Phe Cys Leu Phe Ile Lys Pro Tyr 370 375 380 Ile Arg Asp Met Val Lys Ser Glu Asn Glu Asp Glu Val Arg Ile Ala 385 390 395 400 Lys Glu Val Glu Asp Lys Ser Phe Leu Thr Lys Leu Lys Gly Thr Asn 405 410 415 Asn Ser Val Val Pro Tyr Gin Ile His Glu Arg Glu Leu Asn Gin Ile 420 425 430 Leu Lys Asn Ile Val Ala Tyr Leu Pro Phe Met Asn Asp Glu Gin Glu 435 440 445 Asp Ile Ser Val Val Asp Lys Ile Lys Leu Ile Phe Lys Phe Lys Ile 450 455 460 Page 940 of 3790 Pro Tyr Tyr Val Gly Pro Leu Asn Thr Lys Ser Thr Arg Ser Trp Val 465 470 475 480 Tyr Arg Ser Asp Glu Lys Ile Tyr Pro Trp Asn Phe Ser Asn Val Ile 485 490 495 Asp Leu Asp Lys Thr Ala His Glu Phe Met Asn Arg Leu Ile Gly Arg 500 505 510 Cys Thr Tyr Thr Asn Asp Pro Val Leu Pro Met Asp Ser Leu Leu Tyr 515 520 525 Ser Lys Tyr Asn Val Leu Asn Glu Ile Asn Pro Ile Lys Val Asn Gly 530 535 540 Lys Ala Ile Pro Val Glu Val Lys Gin Ala Ile Tyr Thr Asp Leu Phe 545 550 555 560 Glu Asn Ser Lys Lys Lys Val Thr Arg Lys Ser Ile Tyr Ile Tyr Leu 565 570 575 Leu Lys Asn Gly Tyr Ile Glu Lys Glu Asp Ile Val Ser Gly Ile Asp 580 585 590 Ile Glu Ile Lys Ser Lys Leu Lys Ser His His Asp Phe Thr Gin Ile 595 600 605 Val Gin Glu Asn Lys Cys Thr Pro Glu Glu Ile Glu Arg Ile Ile Lys 610 615 620 Gly Ile Leu Val Tyr Ser Asp Asp Lys Ser Met Leu Arg Arg Trp Leu 625 630 635 640 Lys Asn Asn Ile Lys Gly Leu Ser Glu Asn Asp Val Lys Tyr Leu Ala 645 650 655 Lys Leu Asn Tyr Lys Glu Trp Gly Arg Leu Ser Lys Thr Leu Leu Thr 660 665 670 Asp Ile Tyr Thr Ile Asn Pro Glu Asp Gly Glu Ala Cys Ser Ile Leu 675 680 685 Asp Ile Met Trp Asn Thr Asn Ala Thr Leu Met Glu Ile Leu Ser Asn 690 695 700 Glu Lys Tyr Gin Phe Lys Gin Asn Ile Glu Asn Tyr Lys Ala Glu Asn 705 710 715 720 Page 941 of 3790 Tyr Asp Glu Lys Gin Asn Leu His Glu Glu Leu Asp Asp Met Tyr Ile 725 730 735 Ser Pro Ala Ala Arg Arg Ser Ile Trp Gin Ala Leu Arg Ile Val Asp 740 745 750 Glu Ile Val Asp Ile Lys Lys Ser Ala Pro Lys Lys Ile Phe Ile Glu 755 760 765 Met Ala Arg Glu Lys Lys Ser Ala Met Lys Lys Lys Arg Thr Glu Ser 770 775 780 Arg Lys Asp Thr Leu Leu Glu Leu Tyr Lys Ser Cys Lys Ser Gin Ala 785 790 795 800 Asp Gly Phe Tyr Asp Glu Glu Leu Phe Glu Lys Leu Ser Asn Glu Ser 805 810 815 Asn Ser Arg Leu Arg Arg Asp Gin Leu Tyr Leu Tyr Tyr Thr Gin Met 820 825 830 Gly Arg Ser Met Tyr Thr Gly Lys Arg Ile Asp Phe Asp Lys Leu Ile 835 840 845 Asn Asp Lys Asn Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys 850 855 860 Ile Lys Asp Asp Ser Ile Thr Asn Arg Val Leu Val Glu Lys Asp Ile 865 870 875 880 Asn Gly Glu Lys Thr Asp Ile Tyr Pro Ile Ser Glu Asp Ile Arg Gin 885 890 895 Lys Met Gin Pro Phe Trp Lys Ile Leu Lys Glu Lys Gly Leu Ile Asn 900 905 910 Glu Glu Lys Tyr Lys Arg Leu Thr Arg Asn Tyr Glu Leu Thr Asp Glu 915 920 925 Glu Leu Ser Ser Phe Val Ala Arg Gin Leu Val Glu Thr Gin Gin Ser 930 935 940 Thr Lys Ala Leu Ala Thr Leu Leu Lys Lys Glu Tyr Pro Ser Ala Lys 945 950 955 960 Ile Val Tyr Ser Lys Ala Gly Asn Val Ser Glu Phe Arg Asn Arg Lys 965 975 Page 942 of 3790 970 Asp Lys Glu Leu Pro Lys Phe Arg Glu Ile Asn Asp Leu His His Ala 980 985 990 Lys Asp Ala Tyr Leu Asn Ile Val Val Gly Asn Val Tyr Asp Thr Lys 995 1000 1005 Phe Thr Glu Lys Phe Phe Asn Asn Ile Arg Asn Glu Asn Tyr Ser 1010 1015 1020 Leu Lys Arg Val Phe Asp Phe Ser Val Pro Gly Ala Trp Asp Ala 1025 1030 1035 Lys Gly Ser Thr Phe Asn Thr Ile Lys Lys Tyr Met Ala Lys Asn 1040 1045 1050 Asn Pro Ile Ile Ala Phe Ala Pro Tyr Glu Val Lys Gly Glu Leu 1055 1060 1065 Phe Asp Gin Gin Ile Val Pro Lys Gly Lys Gly Gin Phe Pro Ile 1070 1075 1080 Lys Gin Gly Lys Asp Ile Glu Lys Tyr Gly Gly Tyr Asn Lys Leu 1085 1090 1095 Ser Ser Ala Phe Leu Phe Ala Val Glu Tyr Lys Gly Lys Lys Ala 1100 1105 1110 Arg Glu Arg Ser Leu Glu Thr Val Tyr Ile Lys Asp Val Glu Leu 1115 1120 1125 Tyr Leu Gin Asp Pro Ile Lys Tyr Cys Glu Ser Val Leu Gly Leu 1130 1135 1140 Lys Glu Pro Gin Ile Ile Lys Pro Lys Ile Leu Met Gly Ser Leu 1145 1150 1155 Phe Ser Ile Asn Asn Lys Lys Leu Val Val Thr Gly Arg Ser Gly 1160 1165 1170 Lys Gin Tyr Val Cys His His Ile Tyr Gin Leu Ser Ile Asn Asp 1175 1180 1185 Glu Asp Ser Gin Tyr Leu Lys Asn Ile Ala Lys Tyr Leu Gin Glu 1190 1195 1200 Page 943 of 3790 Asp Leu Leu Lys 1325 192 738 PRT Treponema phagedenis 192 Met Leu Gin Glu Leu Phe Ala Lys Glu Ile Ala Lys Ile Asp Glu Gly 15 10 15 Phe Phe Arg Arg Leu Asp Glu Ser Ala Phe Tyr Leu Glu Asp Lys Ser 20 25 30 Leu Lys Gin Lys 35 Tyr Ser Leu Phe Asn Asp Asp Asn 40 Phe Thr Asp Lys Asp Tyr Tyr Lys Lys Phe Pro Thr 50 55 Ile His His Leu Ile Lys Ala Leu Ile Asn Asp Glu Thr His Val Asp Ile Arg Leu Leu Tyr Leu Ala Cys 65 70 75 80 Page 944 of 3790 His Thr Ile Ile Lys Asn Arg Gly His Phe Leu Phe Glu Gly Lys Glu 85 90 95 Phe Asn Thr Glu Ser Arg Phe Asp Asp Ala Ile Asn Glu Leu Phe Ser 100 105 110 Tyr Leu Arg Gin Asp Met Glu Ile Asp Phe Ala Phe Glu Asp Lys Ile 115 120 125 Ala Asp Ile Lys Glu Ile Leu Glu Asn Lys Lys Ile Gly Met Arg Asp 130 135 140 Lys Gin Asn Ala Leu Asn Lys Lys Leu Ser Ile Ala Pro Lys Asp Lys 145 150 155 160 Gin Lys Lys Glu Ile Ile Lys Leu Ile Val Gly Ala Ser Phe Asn Leu 165 170 175 Lys Thr Leu Phe Asn Asp Glu Lys Tyr Ser Ser Glu Lys Glu Ser Tyr 180 185 190 Ser Phe Ala Lys Ser Asn Tyr Glu Glu Lys Glu Ala Val Leu Glu Ser 195 200 205 Leu Leu Gly Asp Gly Phe Gly Leu Ile Leu Arg Ala Lys Ala Val Tyr 210 215 220 Asp Ser Ser Val Leu Ser Glu Ile Leu Gly Asn Glu Thr Tyr Leu Ser 225 230 235 240 Phe Ala Lys Val Lys Ile Tyr Asp Lys His Lys Glu Asp Leu Ala Lys 245 250 255 Leu Lys Lys Val Ile Lys Thr Tyr His Ala Asp Glu Phe Lys Lys Val 260 265 270 Phe Ala Glu Ala Asn Ile Gin Gly Asn Tyr Cys Ser Tyr Val Gly Ser 275 280 285 Cys Lys Lys Asn Gly Lys Lys Val Pro Ile Glu Lys Arg Ala Asp Lys 290 295 300 Asp Ala Phe Tyr Asp Phe Leu Lys Lys Ile Leu Lys Asp Glu Lys Ala 305 310 315 320 Lys Asn Ser Asp Ala Asp Tyr Ala Phe Ile Leu Asn Glu Ile Glu Leu 325 330 335 Page 945 of 3790 Lys Thr Phe Leu Pro Lys Gin Val Ser Lys Lys Asn Ala Asn Ile Pro 340 345 350 Tyr Gin Leu Arg Arg Met Glu Leu Glu Lys Ile Val Asn Asn Ala Glu 355 360 365 Lys Tyr Phe Ser Phe Leu Ser Glu Lys Asp Glu Tyr Gly Thr Val Lys 370 375 380 Glu Lys Ile Ile Gin Leu Leu Thr Phe Lys Arg Pro Tyr Tyr Ile Gly 385 390 395 400 Ile Ile Gin Asp Thr His Lys Glu Lys Phe Pro Asp Arg Cys Trp Val 405 410 415 Val Lys Lys Glu Asn Ala Lys Asn Glu Lys Ile Thr Pro Trp Asn Phe 420 425 430 Tyr Asp His Ile Asp Glu Asp Lys Thr Ala Glu Ala Phe Ile Thr Ser 435 440 445 Arg Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu Pro Arg 450 455 460 Asn Ser Leu Leu Tyr Met Glu Tyr Thr Val Leu Asn Glu Leu Asn Asn 465 470 475 480 Leu Lys Val Ser Val Asp Gly Val Asn Ile Phe Asp Val Lys Leu Lys 485 490 495 Lys Lys Ile Tyr Glu Gin Val Phe Lys Gin Arg Lys Glu Val Ser Lys 500 505 510 Lys Thr Ile Ala Asp Phe Leu Lys Lys Glu Gly Ile Cys Lys Lys Glu 515 520 525 Asn Asp Val Val Ile Thr Gly Ile Asp Glu Lys Cys Thr Thr Ser Leu 530 535 540 Lys Leu Tyr Ile Asp Ile Lys Lys Ile Ile Gly Lys Arg Ile Glu Glu 545 550 555 560 Glu Pro Thr Lys Asn Ala Leu Glu Asp Ile Ile Leu Trp Ala Ser Ile 565 570 575 Tyr Asp Glu Gly Glu Gly Arg Lys Ile Leu Glu Ala Lys Ile Gin Ser 580 585 590 Page 946 of 3790 Page 947 of 3790 Lys Arg Ala Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Lys Glu Met Ala Lys Val Asp Glu Ser 85 90 95 Phe Phe Gin Arg Leu Glu Glu Ser Phe Leu Thr Asp Asp Asp Lys Thr 100 105 110 Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Thr Tyr 115 120 125 His Gin Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 130 135 140 Ser Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gin Leu Asn Ala 165 170 175 Glu Asn Thr Asp Val Gin Lys Ile Phe Ala Asp Phe Val Gly Val Tyr 180 185 190 Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 195 200 205 Ala Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Lys Gin Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Val Ala Leu Ala Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Asp 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Ala Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser Page 949 of 3790 Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 565 570 575 Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 580 585 590 Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 595 600 605 Asp Asp Lys Thr Asn Glu Gin Ile Ile Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gin Lys Tyr 625 630 635 640 Ser Asp Ile Phe Thr Ser Gin Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 660 665 670 Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 675 680 685 Asp Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Ser 690 695 700 Phe Lys Thr Thr Ile Gin Glu Ala Gin Val Val Gly Asp Val Asp Asp 705 710 715 720 Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 740 745 750 Gly His Asn Pro Gin Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Ile Thr Gly Tyr Gly Arg Asn Arg Ser Asn Gin Arg Leu Lys Arg Leu 770 775 780 Gin Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 785 790 795 800 Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gin Asn Asp 805 810 815 Page 950 of 3790 Asn Phe Phe Lys Thr Glu Val Lys Tyr Ala Asp Gly Arg Val Phe 1055 1060 1065 Page 951 of 3790 Val Asp Asn Leu Ile Asn Glu Phe Thr Glu Tyr Gly Gin Glu Asp 194 1128 PRT Streptococcus vestibularis 194 Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser Lys Page 955 of 3790 Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 645 650 655 Arg Glu Ser Lys Ser Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 660 665 670 Glu Glu Asp Ile Ser Arg Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 675 680 685 Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 690 695 700 Gin Glu His Phe Arg Ala His Lys Thr Asp Thr Lys Val Ser Val Val 705 710 715 720 Arg Gly Gin Phe Thr Ser Gin Leu Arg Arg His Trp Gly Ile Glu Lys 725 730 735 Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 740 745 750 Ala Ser Ser Gin Leu Asn Leu Trp Lys Lys Gin Lys Asn Thr Leu Val 755 760 765 Asn Tyr Ser Glu Asn Gin Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 770 775 780 Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gin His 785 790 795 800 Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 805 810 815 Ser Tyr Gin Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 820 825 830 Ile Tyr Ala Thr Arg Gin Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 835 840 845 Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gin Thr Gly Tyr 850 855 860 Asp Ala Phe Ile Lys Ile Tyr Gin Lys Asp Lys Ser Lys Phe Leu Met 865 870 875 880 Tyr Arg His Asp Pro Gin Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 885 890 895 Page 956 of 3790 195 Page 957 of 3790 25 30 Arg Leu Gin Ser Thr Phe Ala Lys Val Glu Leu Glu Ala Glu Phe Thr Page 959 of 3790 Ala Leu Lys Lys Ile Leu Gin Glu Glu Arg Ile Ser Arg Glu Leu Val 485 490 495 Gly Ser Pro Ser Ala Arg Lys Ala Leu Ile Glu Ala Val Lys Gin Val 500 505 510 Lys Ala Ile Ile Glu Lys Tyr Gly Val Pro Asp Arg Ile His Val Glu 515 520 525 Leu Ala Arg Asp Val Gly Lys Ser Ile Glu Glu Arg Arg Asp Ile His 530 535 540 Phe Gly Ile Glu Lys Arg Ser Arg Gin Lys Asp Lys Leu Arg Glu Leu 545 550 555 560 Phe Gly Lys Glu Val Gly His Leu Pro Gin Asp Gly Glu Arg Gly Lys 565 570 575 Glu Glu Leu Leu Arg Phe Glu Leu Trp Asn Glu Gin Met Gly Arg Cys 580 585 590 Leu Tyr Thr Asp Glu Tyr Ile Asn Pro Lys Gin Leu Val Ala Ser Asp 595 600 605 Asn Ser Val Gin Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 610 615 620 Asp Ser Tyr Leu Asn Lys Thr Leu Cys Thr Ala Lys Ala Asn Gin Asp 625 630 635 640 Lys Lys Gly Arg Thr Pro Tyr Glu Trp Phe Arg Ala Asp Lys Pro Glu 645 650 655 Ala Glu Trp Asp Ala Phe Val Ala Arg Val Glu Ser Ile Gin Phe Met 660 665 670 Lys Gly Leu Lys Lys Arg Asn Tyr Lys Leu Lys Asn Ala Glu Glu Ala 675 680 685 Ala Glu Lys Phe Arg Ser Arg Asn Leu Asn Asp Thr Arg Trp Thr Cys 690 695 700 Arg Leu Leu Ala Glu Ala Leu Lys Gin Leu Tyr Pro Lys Gly Glu Lys 705 710 715 720 Asp Lys Asp Gly Lys Glu Arg Arg Arg Val Phe Thr Arg Pro Gly Ala 725 730 735 Page 960 of 3790 Leu Thr Asn Arg Leu Arg Arg Ala Trp Ser Leu Gin Arg Arg Lys Lys 740 745 750 Ser Glu Lys Gly Glu Arg Ile Ala Asp Asp Arg His His Ala Leu Asp 755 760 765 Ala Ile Ile Val Ala Ala Thr Thr Glu Ser Leu Leu Ile Arg Ala Thr 770 775 780 Arg Glu Val Gin Asp Ile Glu Arg Lys Gly Leu His Tyr Asp Leu Thr 785 790 795 800 Lys Asn Ile Thr Gin Pro Trp Pro Gly Phe Ala Asp Glu Ala Leu Asp 805 810 815 Ala Val Glu Lys Val Phe Val Ala Arg Ala Glu Arg Arg Arg Ala Arg 820 825 830 Gly Lys Ala His Asp Ala Thr Ile Arg His Ile Ala Val Arg Asp Asp 835 840 845 Glu Ala Lys Val Tyr Glu Arg Lys Lys Val Gly Asp Ile Lys Leu Gly 850 855 860 Asp Leu Ile Arg Val Lys Asp Ala Glu Arg Asn Ala Pro Leu Ile Glu 865 870 875 880 Asn Leu Arg Lys Trp Ile Glu Ala Gly Ser Pro Arg Asp Asn Pro Pro 885 890 895 Leu Ser Pro Lys Gly Asp Pro Val Ser Lys Val Arg Leu Val Thr Lys 900 905 910 Asn Lys Val Asn Ile Thr Leu Asp Thr Gly Asn Pro Glu Arg Leu Ala 915 920 925 Thr Val Asp Arg Gly Glu Met Ala Arg Val Asp Val Phe Arg Lys Ala 930 935 940 Asn Arg Lys Gly Lys Tyr Glu Tyr Tyr Leu Val Pro Ile Tyr Pro His 945 950 955 960 Glu Ile Ala Thr Met Glu Thr Pro Pro Met Arg Ala Val Gin Gly Gly 965 970 975 Gly Asp Asp Asp Lys Trp Pro Glu Ile Asp Ser Thr Phe Glu Phe Leu 980 985 990 Page 961 of 3790 Trp Ser Ile Asn Gin Leu Ser Leu Leu Glu Leu Thr Lys Pro Asp Gly 995 1000 1005 196 1087 PRT Phascolarctobacterium succinatutens 196 Met Leu Arg Met Lys Tyr Ala Ile Gly Leu Asp Ile Gly Ile Ala Ser 15 10 15 Val Gly Tyr Ala Val Leu Ala Leu Asp His Glu Glu Asn Pro Trp Gly 20 25 30 Ile Ile Arg Leu Gly Ser Arg Ile Phe Asp Val Ala Glu Asn Pro Lys 35 40 45 Asp Gly Ala Ser Leu Ala Leu Pro Arg Arg Glu Ala Arg Ser Val Arg 50 55 60 Arg Arg Leu Arg Arg His His His Arg Leu Glu Arg Ile Lys Asn Leu 65 70 75 80 Leu Ile Asn Thr Glu Phe Ile Thr Lys Asp Glu Leu Leu His Leu Tyr 85 90 95 Asp Gly Asn Leu 100 Ser Asp Val Tyr Glu 105 Leu Arg Val Lys Ala 110 Leu Asp Tyr Ser Val Thr Asn Ala Glu Leu Thr Arg Ile Leu Leu His Leu Ala 115 120 125 Page 962 of 3790 Gin Arg Arg Gly Phe Lys Ser Asn Arg Lys Ser Asp Ala Asn Asp Lys 130 135 140 Glu Ala Gly Gin Leu Leu Glu Ala Val Ser Ala Asn Ala Lys Arg Met 145 150 155 160 Gin Glu Asn His Tyr Arg Thr Val Gly Glu Met Phe Tyr Lys Asp Asp 165 170 175 Leu Phe Ser Lys Tyr Lys Arg Asn Lys Gly Gly Thr Tyr Leu Thr Thr 180 185 190 Val His Arg Asp Met Ile Ala Ala Glu Ala Arg Thr Ile Leu Glu Lys 195 200 205 Gin Phe Ala Leu Gly Asn Asn Ile Cys Thr Gin Asp Phe Ile Asp Lys 210 215 220 Tyr Leu Ser Ile Leu Leu Ser Gin Arg Gin Phe Asp Glu Gly Pro Gly 225 230 235 240 Glu Pro Ser Pro Tyr Ala Gly Asn Gin Ile Ala Asn Met Ile Gly Lys 245 250 255 Cys Thr Phe Glu Pro Asn Glu Tyr Arg Ala Ala Lys Ala Ser Tyr Ser 260 265 270 Phe Glu Arg Phe Asn Leu Leu Gin Lys Val Asn His Leu Arg Leu Leu 275 280 285 Leu Glu Gly Lys Ser Ile Ala Leu Asp Asn Glu Gin Arg Lys Lys Ile 290 295 300 Ile Ala Leu Ala His Asp Lys Ala Asp Leu Arg Tyr Ser His Ile Arg 305 310 315 320 Lys Ala Leu Gly Leu Asp Glu Lys Val Leu Phe Asn Thr Ile Thr Tyr 325 330 335 Asn Asp Asp Val Ser Val Ile Glu Lys Lys Thr Lys Phe Asn Phe Leu 340 345 350 Gin Ala Tyr His Gin Ile Lys Lys Val Leu Ala Glu Asp Met Gin Lys 355 360 365 Leu Thr Thr Glu Gin Leu Asp Asn Ile Gly Gin Ile Leu Ser Thr Tyr Page 965 of 3790 Lys Pro Phe Arg 1085 Page 966 of 3790 Met Arg Lys Asn Gin Glu Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr 15 10 15 Ser Ser Ile Gly Trp Ser Ile Met Asn Asp Asn Phe Asp Leu Met Arg 20 25 30 Val Lys Gly Lys Lys Gly Ile Gly Val Arg Leu Tyr Asn Glu Gly Gin 35 40 45 Ser Ala Ala Glu Arg Arg Met His Arg Thr Ala Arg Arg Arg Tyr Gly 50 55 60 Arg Arg Lys Trp Arg Leu Arg Leu Leu Glu Asp Phe Phe Asp Glu His 65 70 75 80 Met Ala Glu Val Asp Asp Thr Phe Phe Ala Arg Leu Lys Asp Ser Asn 85 90 95 Ile Ser Pro Lys Asp Asp Lys Lys Tyr Arg Lys Ser Leu Leu Phe Pro 100 105 110 Lys Ser Lys Gly Val Thr Tyr Gin Asp Asp Gly Glu Phe Tyr Lys Lys 115 120 125 Tyr Pro Thr Met Tyr His Leu Arg Tyr Ala Leu Met Thr Glu His Arg 130 135 140 Lys Phe Asp Leu Arg Glu Ile Tyr Leu Ala Phe His His Met Val Lys 145 150 155 160 Tyr Arg Gly Asn Phe Leu Tyr Asp Thr Ser Val Asp Ser Phe Glu Ala 165 170 175 Lys Asn Leu Asp Ile Lys Gly Lys Phe Asp Glu Ile Asn Asp Leu Leu 180 185 190 Ser Ser Tyr Thr Asp Phe Tyr Val Asp Asn Ser Asn Ala Ala Leu Val 195 200 205 Glu Ser Ile Leu Leu Glu Lys Asn Thr Thr Arg Lys Asp Lys Ser Lys 210 215 220 Lys Ile Ala Lys Leu Leu His Val Glu Asp Lys Glu Lys Gly Lys Asn 225 230 235 240 Lys Lys Ala Lys Asp Leu Ala Thr Gin Ile Ser Asn Ala Val Leu Gly 245 250 255 Page 967 of 3790 Leu Lys Cys Asn Phe His Leu Ile Phe Glu Leu Gin Gin Lys Tyr Ser 260 265 270 Phe Asp Leu Cys Ser Glu Lys Thr Glu Glu Asn Ile Ala Lys Leu Ser 275 280 285 Glu Val Leu Asp Glu Asn Gin Lys Met Leu Leu Met Ile Leu Lys Glu 290 295 300 Val Gin Asp Gin Val Met Leu Asn Ala Phe Val Pro Ser Gly Met Ser 305 310 315 320 Leu Ser Glu Ala Met Met Gin Lys Tyr Asp Asp Tyr Gly Glu Gin Leu 325 330 335 Lys Ile Tyr His Glu Leu Glu His Ser Val Ser Asp Asp Ser Ala Ala 340 345 350 Lys Leu Arg Gly Ala Tyr Arg Asp Tyr Asn Asp Asn Ile Ile Lys Arg 355 360 365 Ile Asp Gly Asp Asn Lys Lys Asp Thr Phe Tyr Lys Arg Val Lys Asn 370 375 380 Ile Leu Thr Lys Ile Ser Lys Glu Tyr Val Asp Gin Asp Val Leu Glu 385 390 395 400 Ser Cys Gly Lys Leu Lys Lys Leu Ile Asp Glu Asn Lys Leu Phe Ile 405 410 415 Arg Gin Arg Thr Ala Ala Asn Gly Val Leu Pro His Gin Leu His Gin 420 425 430 Ile Glu Met Arg Lys Ile Ile Asp Asn Gin Lys Glu Tyr Tyr Pro Trp 435 440 445 Leu Ala Glu Pro Asn Pro Asn Glu Lys Arg Arg Val Tyr Ser Lys Tyr 450 455 460 Lys Val Glu Glu Leu Ile Ala Phe Arg Ile Pro Tyr Tyr Val Gly Pro 465 470 475 480 Leu Val Asp Pro Asn Asn Ala Asp Lys Asn Lys Glu Ala Arg Phe Ser 485 490 495 Trp Met Val Arg Lys Lys Asp Gly Glu Ile Thr Pro Trp Asn Phe Tyr Lys Asn Arg Asn Val 995 Asn Asp Tyr 1000 His His Ala Phe Asp Ala Tyr Leu 1005 Page 970 of 3790 Page 971 of 3790 1370 1375 198 1391 PRT Prevotella oralis 198 Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 15 10 15 Ala Leu Val Asn Glu Lys Glu Asn Asn Glu Glu Leu Ser Ser Ile Ile 20 25 30 Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Ser Asn 35 40 45 Phe Glu Lys Gly Lys Asp Ile Thr Thr Asn Ala Asp Arg Thr Lys Cys 50 55 60 Arg Ser Ala Arg Arg Asn Leu Gin Arg Phe Lys Leu Arg Arg Glu Ala 65 70 75 80 Page 972 of 3790 Leu Ala Asp Cys Leu Lys Arg His Gly Leu Met Thr Asp Glu Thr Pro 85 90 95 Leu Cys Glu Thr Asn Asn Ser Ile Ile Phe Lys Thr Tyr Ser Asn Arg 100 105 110 Ala Lys Ala Val Cys Glu Lys Ile Ala Leu Asp Asp Phe Val Arg Val 115 120 125 Leu Phe Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Leu 130 135 140 Asn Thr Asp Asp Glu Gly Thr Leu Val Asp Gly Met Asp Val Ala Lys 145 150 155 160 Leu Leu Tyr Asn Glu Gin Ile Thr Pro Gly Glu Tyr Leu Leu Arg Leu 165 170 175 Phe Lys Lys Gly Lys Lys Thr Arg Pro Asp Phe Tyr Leu Ser Asp Leu 180 185 190 Lys Ala Glu Leu Glu Arg Ile Trp Asp Phe Gin Arg Thr Phe Tyr Pro 195 200 205 Glu Ile Leu Cys Asn Ala Leu Lys Glu Asp Leu Lys Gly Lys Ser Arg 210 215 220 Thr Gin Ser Ser Ala Ile Phe Tyr Ala Lys Tyr Lys Val Ser Thr Ala 225 230 235 240 Lys Ile Ala Gly Lys Asp Lys Arg Leu Gin Glu Leu Thr Trp Arg Thr 245 250 255 Asp Ala Leu Arg Lys Gin Leu Thr Ile Asp Glu Val Ala Tyr Val Ile 260 265 270 Cys Ser Ile Asn Gly Glu Val Asn Gly Ser Ser Gin Arg Leu Ser Met 275 280 285 Ile Ser Asp Arg Ser Lys Leu Leu Tyr Phe Asn His Gin Thr Ile Gly 290 295 300 Gin Tyr Leu Met Gin Arg Leu Glu Glu Asn Pro Asn Ala Gly Leu Lys 305 310 315 320 Asn Ile Ile Phe Tyr Arg Gin Asp Tyr Glu Asp Glu Phe Asn Asp Ile Page 974 of 3790 Asp Gin Ser Lys Thr Gly Ile Glu Ala Leu Val Lys Arg Ile Gin Glu 580 585 590 Leu Cys Gly Phe Glu Pro Glu Tyr Ala Arg Ile Leu Ala Asn Ile Ser 595 600 605 Phe Ile Pro Asp Tyr Gly Asn Leu Ser Ser Lys Ala Met Arg Lys Ile 610 615 620 Leu Pro Tyr Met Gin Asp Gly Tyr Glu Tyr Ser Glu Ala Cys Ser Lys 625 630 635 640 Ala Gly Tyr Arg His Ser Ala Ser Ser Leu Thr Lys Glu Glu Ile Asn 645 650 655 Lys Lys Asn Tyr Lys Thr His Leu Asp Glu Ile Lys Arg Asn Ser Leu 660 665 670 Arg Asn Pro Ile Val Glu Lys Ile Leu Asn Gin Met Val Asn Val Val 675 680 685 Asn Ser Val Ile Asp Thr Tyr Ser Asn Ile Asp Glu Ile Arg Ile Glu 690 695 700 Met Ala Arg Glu Leu Lys Lys Ser Lys Pro Glu Arg Glu Asp Met Ser 705 710 715 720 Phe Ala Ile Ser Lys Ala Thr Lys Glu Thr Glu Arg Ile Lys Gly Ile 725 730 735 Leu Glu Gin Glu Phe Lys Ile Gin His Val Thr Arg Asn Asp Ile Ile 740 745 750 Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Pro Asn Gly Tyr Lys Thr Leu 755 760 765 Tyr Ser Asn Thr Tyr Ile Pro Arg Glu Asp Leu Phe Ser Lys Lys Phe 770 775 780 Asp Ile Glu His Ile Ile Pro Lys Ala Arg Leu Phe Asp Asp Ser Tyr 785 790 795 800 Ser Asn Lys Thr Leu Glu Leu Arg Asp Ile Asn Ile Glu Lys Gly Asn 805 810 815 Gin Thr Ala Tyr Asp Phe Val Leu Ser Lys Tyr Gly Glu Glu Gly Leu 820 825 830 Page 975 of 3790 Page 976 of 3790 Phe Asn Pro Ser Glu Ile Ser Leu Lys Asp Glu Lys Asn Tyr Ala Page 977 of 3790 1310 1315 1320 1385 1390 Ile Thr Asn Lys Met Val Leu Thr Asn Pro Gin Lys Gin Lys Thr Ile Page 980 of 3790 Asp His Ile Ile Pro Tyr Ser Phe Leu Pro Ile Asp Ser Ile Asp Asn 645 650 655 Lys Val Leu Thr His Arg Lys Asn Asn Gin Arg Lys Leu Asp Asn Ile 660 665 670 Pro Asp Lys Glu Thr Val Ala His Met Lys Pro Phe Trp Glu Ala Leu 675 680 685 Tyr Asn Ala Lys Leu Ile Ser Gin Thr Lys Tyr Gin Arg Leu Thr Thr 690 695 700 Ser Glu Arg Thr Pro Asp Gly Val Leu Thr Glu Ser Met Lys Ala Gly 705 710 715 720 Phe Ile Glu Arg Gin Leu Val Glu Thr Arg Gin Ile Ile Lys His Val 725 730 735 Ala Arg Ile Leu Asp Asn Arg Phe Ser Asp Thr Lys Ile Ile Thr Leu 740 745 750 Lys Ser Gin Leu Val Thr Asn Phe Arg Asn Thr Phe His Ile Ala Lys 755 760 765 Ile Arg Glu Leu Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Ala 770 775 780 Val Val Val Gly Gin Thr Leu Leu Lys Ala Tyr Pro Lys Leu Ala Pro 785 790 795 800 Glu Leu Ile Tyr Gly His His Val His Phe Asn Arg His Glu Glu Asn 805 810 815 Lys Ala Thr Leu Arg Lys His Leu Tyr Ser Asn Ile Met Arg Phe Phe 820 825 830 Asn Asn Pro Asp Ser Lys Val Ser Lys Asp Ile Trp Asp Cys Asn Arg 835 840 845 Asp Leu Pro Ile Ile Lys His Val Ile Tyr Asn Ser Gin Ile Asn Phe 850 855 860 Val Lys Arg Thr Met Ile Lys Lys Gly Ala Phe Tyr Asn Gin Asn Pro 865 870 875 880 Val Gly Lys Phe Asn Lys Gin Leu Ala Ala Asn Asn Arg Tyr Pro Leu 885 890 895 Page 981 of 3790 Thr Val Ala Arg Met Arg Pro Lys Pro Asp Lys Arg Leu Leu Asn 200 1334 PRT Staphylococcus pseudintermedius 200 Leu Ile Glu Thr Tyr Glu Asn Leu Asn Asn Ile Lys Leu Asn Leu Asp Page 984 of 3790 Ala Glu Ile Thr Asp Glu Met Ile Glu Lys Val Leu Ser Leu Ile Gin 435 440 445 Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Asn Asp His Thr Ala 450 455 460 Ser Lys Phe Gly Trp Met Glu Arg Lys Ser Asn Glu Ser Ile Lys Pro 465 470 475 480 Trp Asn Phe Asp Glu Val Val Asp Arg Ser Lys Ser Ala Thr Gin Phe 485 490 495 Ile Arg Arg Met Thr Asn Lys Cys Ser Tyr Leu Ile Asn Glu Asp Val 500 505 510 Leu Pro Lys Asn Ser Leu Leu Tyr Gin Glu Met Glu Val Leu Asn Glu 515 520 525 Leu Asn Ala Thr Gin Ile Arg Leu Gin Thr Asp Pro Lys Asn Arg Lys 530 535 540 Tyr Arg Met Met Pro Gin Ile Lys Leu Phe Ala Val Glu His Ile Phe 545 550 555 560 Lys Lys Tyr Lys Thr Val Ser His Ser Lys Phe Leu Glu Ile Met Leu 565 570 575 Asn Ser Asn His Arg Glu Asn Phe Met Asn His Gly Glu Lys Leu Ser 580 585 590 Ile Phe Gly Thr Gin Asp Asp Lys Lys Phe Ala Ser Lys Leu Ser Ser 595 600 605 Tyr Gin Asp Met Thr Lys Ile Phe Gly Asp Ile Glu Gly Lys Arg Ala 610 615 620 Gin Ile Glu Glu Ile Ile Gin Trp Ile Thr Ile Phe Glu Asp Lys Lys 625 630 635 640 Ile Leu Val Gin Lys Leu Lys Glu Cys Tyr Pro Glu Leu Thr Ser Lys 645 650 655 Gin Ile Asn Gin Leu Lys Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu 660 665 670 Ser Glu Lys Leu Leu Thr His Ala Tyr Gin Gly His Ser Ile Ile Glu 675 680 685 Page 985 of 3790 Leu Leu Arg His Ser Asp Glu Asn Phe Met Glu Ile Leu Thr Asn Asp 690 695 700 Val Tyr Gly Phe Gin Asn Phe Ile Lys Glu Glu Asn Gin Val Gin Ser 705 710 715 720 Asn Lys Ile Gin His Gin Asp Ile Ala Asn Leu Thr Thr Ser Pro Ala 725 730 735 Leu Lys Lys Gly Ile Trp Ser Thr Ile Lys Leu Val Arg Glu Leu Thr 740 745 750 Ser Ile Phe Gly Glu Pro Glu Lys Ile Ile Met Glu Phe Ala Thr Glu 755 760 765 Asp Gin Gin Lys Gly Lys Lys Gin Lys Ser Arg Lys Gin Leu Trp Asp 770 775 780 Asp Asn Ile Lys Lys Asn Lys Leu Lys Ser Val Asp Glu Tyr Lys Tyr 785 790 795 800 Ile Ile Asp Val Ala Asn Lys Leu Asn Asn Glu Gin Leu Gin Gin Glu 805 810 815 Lys Leu Trp Leu Tyr Leu Ser Gin Asn Gly Lys Cys Met Tyr Ser Gly 820 825 830 Gin Ser Ile Asp Leu Asp Ala Leu Leu Ser Pro Asn Ala Thr Lys His 835 840 845 Tyr Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser 850 855 860 Ile Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn Gin Thr Lys Gly 865 870 875 880 Asp Gin Val Pro Leu Gin Phe Ile Gin Gin Pro Tyr Glu Arg Ile Ala 885 890 895 Tyr Trp Lys Ser Leu Asn Lys Ala Gly Leu Ile Ser Asp Ser Lys Leu 900 905 910 His Lys Leu Met Lys Pro Glu Phe Thr Ala Met Asp Lys Glu Gly Phe 915 920 925 Ile Gin Arg Gin Leu Val Glu Thr Arg Gin Ile Ser Val His Val Arg 930 935 940 Page 986 of 3790 Asn Lys Gly Asp Leu Leu Tyr Ile Asn Asn His Pro Cys Tyr Phe Page 987 of 3790 1175 1180 1185 1325 1330 201 1156 PRT Ruminococcus albus 201 Ala Ser Gin Gin Cys Arg Arg Ser Arg Gly Leu Arg Arg Leu Tyr Arg Page 989 of 3790 Val Phe Asp Thr Ser Phe Ala Asn Asp Leu Ile Asn Ser Ala Leu Lys 305 310 315 320 Asn Gly Ser Met Asp Lys Arg Glu Leu Lys Ala Ile Ala Lys Ser Tyr 325 330 335 His Ile Asp Ile Ser Asp Lys Asn Ser Asp Thr Ser Leu Thr Lys Cys 340 345 350 Phe Lys Tyr Ile Lys Val Val Lys Pro Leu Phe Glu Lys Tyr Gly Tyr 355 360 365 Asp Trp Asp Lys Leu Ile Glu Asn Tyr Thr Asp Thr Asp Asn Asn Val 370 375 380 Leu Asn Arg Ile Gly Ile Val Leu Ser Gin Ala Gin Thr Pro Lys Arg 385 390 395 400 Arg Arg Glu Lys Leu Lys Ala Leu Asn Ile Gly Leu Asp Asp Gly Leu 405 410 415 Ile Asn Glu Leu Thr Lys Leu Lys Leu Ser Gly Thr Ala Asn Val Ser 420 425 430 Tyr Lys Tyr Met Gin Gly Ser Ile Glu Ala Phe Cys Glu Gly Asp Leu 435 440 445 Tyr Gly Lys Tyr Gin Ala Lys Phe Asn Lys Glu Ile Pro Asp Ile Asp 450 455 460 Glu Asn Ala Lys Pro Gin Lys Leu Pro Pro Phe Lys Asn Glu Asp Asp 465 470 475 480 Cys Glu Phe Phe Lys Asn Pro Val Val Phe Arg Ser Ile Asn Glu Thr 485 490 495 Arg Lys Leu Ile Asn Ala Ile Ile Asp Lys Tyr Gly Tyr Pro Ala Ala 500 505 510 Val Asn Ile Glu Thr Ala Asp Glu Leu Asn Lys Thr Phe Glu Asp Arg 515 520 525 Ala Ile Asp Thr Lys Arg Asn Asn Asp Asn Gin Lys Glu Asn Asp Arg 530 535 540 Ile Val Lys Glu Ile Ile Glu Cys Ile Lys Cys Asp Glu Val His Ala 545 550 555 560 Page 990 of 3790 Arg His Leu Ile Glu Lys Tyr Lys Leu Trp Glu Ala Gin Glu Gly Lys 565 570 575 Cys Leu Tyr Ser Gly Glu Thr Ile Thr Lys Glu Asp Met Leu Arg Asp 580 585 590 Lys Asp Lys Leu Phe Glu Val Asp His Ile Val Pro Tyr Ser Leu Ile 595 600 605 Leu Asp Asn Thr Ile Asn Asn Lys Ala Leu Val Tyr Ala Glu Glu Asn 610 615 620 Gin Lys Lys Gly Gin Arg Thr Pro Leu Met Tyr Met Asn Glu Ala Gin 625 630 635 640 Ala Ala Asp Tyr Arg Val Arg Val Asn Thr Met Phe Lys Ser Lys Lys 645 650 655 Cys Ser Lys Lys Lys Tyr Gin Tyr Leu Met Leu Pro Asp Leu Asn Asp 660 665 670 Gin Glu Leu Leu Gly Gly Trp Arg Ser Arg Asn Leu Asn Asp Thr Arg 675 680 685 Tyr Ile Cys Lys Tyr Leu Val Asn Tyr Leu Arg Lys Asn Leu Arg Phe 690 695 700 Asp Arg Ser Tyr Glu Ser Ser Asp Glu Asp Asp Leu Lys Ile Arg Asp 705 710 715 720 His Tyr Arg Val Phe Pro Val Lys Ser Arg Phe Thr Ser Met Phe Arg 725 730 735 Arg Trp Trp Leu Asn Glu Lys Thr Trp Gly Arg Tyr Asp Lys Ala Glu 740 745 750 Leu Lys Lys Leu Thr Tyr Leu Asp His Ala Ala Asp Ala Ile Ile Ile 755 760 765 Ala Asn Cys Arg Pro Glu Tyr Val Val Leu Ala Gly Glu Lys Leu Lys 770 775 780 Leu Asn Lys Met Tyr His Gin Ala Gly Lys Arg Ile Thr Pro Glu Tyr 785 790 795 800 Glu Gin Ser Lys Lys Ala Cys Ile Asp Asn Leu Tyr Lys Leu Phe Arg 805 810 815 Page 991 of 3790 Pro Asp Asp Tyr Tyr Thr His Val Met Tyr Ile Phe Pro Gly Asp 202 1440 PRT Weeksella virosa 202 Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Glu Gin Asp Phe 20 Glu Asn Lys 25 Gin Gly Leu Ile Leu Gly 30 Met Gly Ser Arg 35 Ile Ile Pro Met 40 Asp Ala Gly Ile Ile Gly Lys Phe 45 Ala Glu Gly Ser Ser Ile Ser Gin Thr Ala Glu Arg Thr Gly Tyr Arg 50 55 60 Ser Ile Arg Arg Leu Arg 70 Glu Arg His Leu Leu Arg Arg 75 Glu Arg Leu 80 His Arg Val Leu Asn 85 Ile Leu Lys Phe Leu 90 Pro Glu His Tyr Ala Ala 95 Glu Ile Asp Phe 100 Glu Lys Arg Phe Gly Gin 105 Phe Leu Ala Glu 110 Thr Glu Pro Lys Leu Ala Trp Lys Lys Asn Ala Glu Gly Lys Phe Glu Phe Leu Page 993 of 3790 115 120 125 Phe Gin Arg Ser Phe Asp Glu Met Val Ala Asp Phe Lys Ala Asn Gly 130 135 140 Gin Asp Ile Lys Ile Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 145 150 155 160 Lys Ala Leu Thr Gin Lys Ile Ser Pro Gin Glu Leu Ala Trp Ile Ile 165 170 175 Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr Gin Leu Arg Gly Glu Glu 180 185 190 Glu Glu Glu Asn Pro Asn Lys Lys Val Glu Phe Tyr Ser Leu Lys Ile 195 200 205 Val Asp Val Val Ala Asp Glu Gin Pro Asn Lys Lys Gly Asp Thr Trp 210 215 220 Tyr Ser Leu His Leu Glu Asn Gly Trp Val Tyr Arg Arg Ser Ser Lys 225 230 235 240 Ile Pro Leu Tyr Asp Trp Lys Asp Lys Val Arg Asp Phe Ile Val Thr 245 250 255 Thr Asp Ile Asn Glu Asp Gly Ser Glu Lys Leu Asp Lys Asp Gly Glu 260 265 270 Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp Trp Thr Leu Ile 275 280 285 Lys Lys Lys Thr Glu Gin Glu Ile Glu Gin Phe Asn Gin Thr Val Gly 290 295 300 Ser Tyr Ile Tyr Glu Ala Leu Leu Asp Asn Pro Thr Gin Lys Ile Arg 305 310 315 320 Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Ser Glu Leu 325 330 335 Lys Lys Ile Leu Glu Lys Gin Ile Glu Leu Gin Pro Glu Leu Phe Thr 340 345 350 Glu Asp Leu Tyr Asn Ala Cys Ala Arg Glu Leu Tyr Arg Arg Asn Val 355 360 365 Page 994 of 3790 Ala His Gin Gin Gin Leu Ser Ser Arg Asp Phe Val Tyr Leu Phe Leu 370 375 380 Asn Asp Ile Ile Phe Tyr Gin Arg Pro Leu Arg Ser Gin Lys Ser Leu 385 390 395 400 Ile Ser Asn Cys Ser Leu Glu Phe Arg Thr Ile Lys Asp Lys Asp Gly 405 410 415 Asn Gly Gin Ile Ile Tyr Leu Lys Ala Ile Pro Lys Ser Asn Pro Tyr 420 425 430 Tyr Gin Glu Phe Arg Val Trp Gin Trp Leu Tyr Asn Leu Lys Ile Phe 435 440 445 Thr Lys Glu Asp Asp Lys Asp Val Thr Asn Gin Phe Ile Asn Lys Val 450 455 460 Glu Asp Leu Glu Ala Leu Phe Glu Phe Leu Met Asn Gin Lys Glu Val 465 470 475 480 Asn His Thr Asp Ile Leu Thr Tyr Leu Ile Glu Pro Ile Val Lys Ser 485 490 495 Lys Tyr Pro Asn Ala Lys Gly Lys Ala Phe Lys Asp Glu Leu Lys Lys 500 505 510 Glu Leu Lys Lys Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Asp Lys Asp 515 520 525 Glu Ser Lys Ser Tyr Pro Met Asn Glu Thr Arg Tyr Glu Leu Arg Lys 530 535 540 Arg Leu Asp Lys Val Glu Asn Val Pro Ala Asp Phe Met Thr Arg Lys 545 550 555 560 Ile Glu Gin His Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Ile 565 570 575 Glu Phe Glu Lys Ala Leu Lys Ser Phe Ala Asn Lys Tyr Asp Leu His 580 585 590 Gin Glu Ser Phe Val Glu Asn Phe Lys Arg Phe Lys Pro Phe Asp Ser 595 600 605 Asp Tyr Gly Thr Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu 610 615 620 Page 995 of 3790 Met Arg Val Gly Lys Tyr Trp Ser Trp Asp Ile Ile Asp Asp Lys Thr 625 630 635 640 Lys Thr Arg Ile Gly Lys Ile Ile Thr Gly Glu Tyr Asp Glu Thr Ile 645 650 655 Lys Asn Arg Val Arg Glu Lys Ala Ile Asp Leu Thr Glu Glu Asn His 660 665 670 Phe Gin Gly Leu Gin Leu Trp Leu Ala Gin Tyr Ile Val Tyr Asp Arg 675 680 685 His Ser Glu Ala Asp Ile Ala Gly Lys Trp Asn Ser Val Ala Asp Leu 690 695 700 Glu Gin Tyr Leu Ser Glu Phe Lys Gin His Ser Leu Arg Asn Pro Ile 705 710 715 720 Val Glu Gin Val Ile Thr Glu Thr Leu Arg Val Val Arg Asp Ile Trp 725 730 735 Lys Gin Tyr Gly Lys Gly Ala Lys Asp Tyr Phe Asp Glu Ile His Ile 740 745 750 Glu Leu Gly Arg Glu Met Lys Asn Thr Ala Glu Glu Arg Lys Arg Leu 755 760 765 Ser Ser Ile Ile Ser Glu Asn Glu Thr Thr Asn Leu Arg Ile Arg Ala 770 775 780 Ile Leu Glu Glu Leu Met Tyr Asp Glu Asn Met Glu Asn Val Arg Pro 785 790 795 800 Tyr Ser Pro Met Gin Gin Glu Ala Leu Lys Ile Tyr Glu Asp Gly Val 805 810 815 Leu Ser Ser Ser Val Glu Ile Pro Glu Asp Ile Glu Lys Ile Ser Lys 820 825 830 Lys Ser Glu Pro Thr Lys Ser Glu Ile Gin Arg Tyr Lys Leu Trp Leu 835 840 845 Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Arg Pro Ile Pro Leu Ser 850 855 860 Lys Leu Phe Thr Pro Ala Tyr Gin Ile Glu His Ile Ile Pro Gin Ala 865 870 875 880 Page 996 of 3790 Asp Lys Glu Gly Lys Val Arg Thr Lys Phe Thr Glu Phe Lys Lys Page 998 of 3790 Cys Gin Arg Leu Gly Ser Arg Pro Tyr Ser Ile Gly Leu Asp Leu Gly 20 25 30 Val Gly Ser Ile Gly Val Ala Val Ala Ala Tyr Asp Pro Ile Lys Lys 35 40 45 Gin Pro Ser Asp Leu Val Phe Val Ser Ser Arg Ile Phe Ile Pro Ser 50 55 60 Thr Gly Ala Ala Glu Arg Arg Gin Lys Arg Gly Gin Arg Asn Ser Leu 65 70 75 80 Arg His Arg Ala Asn Arg Leu Lys Phe Leu Trp Lys Leu Leu Ala Glu 85 90 95 Arg Asn Leu Met Leu Ser Tyr Ser Glu Gin Asp Val Pro Asp Pro Ala 100 105 110 Arg Leu Arg Phe Glu Asp Ala Val Val Arg Ala Asn Pro Tyr Glu Leu 115 120 125 Page 1000 of 3790 Glu Gin Lys Asp Asp Phe Phe Ser Ala Trp Thr Asn Thr Pro Asp Asp 385 390 395 400 Lys Arg Leu Ser Lys Tyr Leu Met Lys His Leu Leu Leu Thr Glu Asn 405 410 415 Glu Val Val Asp Ala Leu Lys Thr Val Ser Leu Ile Gly Asp Tyr Gly 420 425 430 Pro Ile Gly Lys Thr Ala Thr Gin Leu Leu Met Lys His Leu Glu Asp 435 440 445 Gly Leu Thr Tyr Thr Glu Ala Leu Glu Arg Gly Met Glu Thr Gly Glu 450 455 460 Phe Gin Glu Leu Ser Val Trp Glu Gin Gin Ser Leu Leu Pro Tyr Tyr 465 470 475 480 Gly Gin Ile Leu Thr Gly Ser Thr Gin Ala Leu Met Gly Lys Tyr Trp 485 490 495 His Ser Ala Phe Lys Glu Lys Arg Asp Ser Glu Gly Phe Phe Lys Pro 500 505 510 Asn Thr Asn Ser Asp Glu Glu Lys Tyr Gly Arg Ile Ala Asn Pro Val 515 520 525 Val His Gin Thr Leu Asn Glu Leu Arg Lys Leu Met Asn Glu Leu Ile 530 535 540 Thr Ile Leu Gly Ala Lys Pro Gin Glu Ile Thr Val Glu Leu Ala Arg 545 550 555 560 Glu Leu Lys Val Gly Ala Glu Lys Arg Glu Asp Ile Ile Lys Gin Gin 565 570 575 Thr Lys Gin Glu Lys Glu Ala Val Leu Ala Tyr Ser Lys Tyr Cys Glu 580 585 590 Pro Asn Asn Leu Asp Lys Arg Tyr Ile Glu Arg Phe Arg Leu Leu Glu 595 600 605 Asp Gin Ala Phe Val Cys Pro Tyr Cys Leu Glu His Ile Ser Val Ala 610 615 620 Asp Ile Ala Ala Gly Arg Ala Asp Val Asp His Ile Phe Pro Arg Asp 625 630 635 640 Page 1001 of 3790 Asp Thr Ala Asp Asn Ser Tyr Gly Asn Lys Val Val Ala His Arg Gin 645 650 655 Cys Asn Asp Ile Lys Gly Lys Arg Thr Pro Tyr Ala Ala Phe Ser Asn 660 665 670 Thr Ser Ala Trp Gly Pro Ile Met His Tyr Leu Asp Glu Thr Pro Gly 675 680 685 Met Trp Arg Lys Arg Arg Lys Phe Glu Thr Asn Glu Glu Glu Tyr Ala 690 695 700 Lys Tyr Leu Gin Ser Lys Gly Phe Val Ser Arg Phe Glu Ser Asp Asn 705 710 715 720 Ser Tyr Ile Ala Lys Ala Ala Lys Glu Tyr Leu Arg Cys Leu Phe Asn 725 730 735 Pro Asn Asn Val Thr Ala Val Gly Ser Leu Lys Gly Met Glu Thr Ser 740 745 750 Ile Leu Arg Lys Ala Trp Asn Leu Gin Gly Ile Asp Asp Leu Leu Gly 755 760 765 Ser Arg His Trp Ser Lys Asp Ala Asp Thr Ser Pro Thr Met Arg Lys 770 775 780 Asn Arg Asp Asp Asn Arg His His Gly Leu Asp Ala Ile Val Ala Leu 785 790 795 800 Tyr Cys Ser Arg Ser Leu Val Gin Met Ile Asn Thr Met Ser Glu Gin 805 810 815 Gly Lys Arg Ala Val Glu Ile Glu Ala Met Ile Pro Ile Pro Gly Tyr 820 825 830 Ala Ser Glu Pro Asn Leu Ser Phe Glu Ala Gin Arg Glu Leu Phe Arg 835 840 845 Lys Lys Ile Leu Glu Phe Met Asp Leu His Ala Phe Val Ser Met Lys 850 855 860 Thr Asp Asn Asp Ala Asn Gly Ala Leu Leu Lys Asp Thr Val Tyr Ser 865 870 875 880 Ile Leu Gly Ala Asp Thr Gin Gly Glu Asp Leu Val Phe Val Val Lys 885 895 Page 1002 of 3790 890 Page 1003 of 3790 204 1370 PRT Streptococcus gallolyticus 204 Met Thr Lys Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 15 10 15 Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys 20 25 30 Met Lys Val Leu Gly Asn Thr Asp Lys Lys Tyr Ile Lys Lys Asn Leu 35 40 45 Leu Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 50 55 60 Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 65 70 75 80 Arg Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Thr Lys Val Asp Glu 85 90 95 Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 100 105 110 Asp Phe Glu Arg His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala 115 120 125 Tyr His Gin Lys Phe Pro Thr Ile Tyr His Leu Arg Asn Tyr Leu Ala 130 135 140 Asp Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala 145 150 155 160 Page 1004 of 3790 His Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Asn 165 170 175 Ala Glu Asn Thr Asp Val Gin Lys Leu Phe Thr Asp Phe Val Gly Val 180 185 190 Tyr Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp 195 200 205 Val Ala Ser Thr Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu 210 215 220 Asn Leu Ile Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly 225 230 235 240 Asn Leu Ile Ala Leu Ala Leu Gly Leu Gin Pro Asn Phe Lys Met Asn 245 250 255 Phe Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr 260 265 270 Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 275 280 285 Asp Leu Phe Thr Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu 325 330 335 Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 340 345 350 Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 355 360 365 Lys Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 370 375 380 Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Page 1005 of 3790 Leu Gin Glu Met His Ala Ile Leu Arg Arg Gin Gly Asp Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Lys Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 450 455 460 Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 465 470 475 480 Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 485 490 495 Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 515 520 525 Lys Tyr Val Asn Glu Gin Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 530 535 540 Lys Gin Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 545 550 555 560 Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 565 570 575 Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 595 600 605 Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 610 615 620 Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gin Lys 625 630 635 640 Tyr Ser Asp Ile Phe Thr Ala Asn Gin Leu Lys Lys Leu Glu Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 660 665 670 Page 1006 of 3790 Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 675 680 685 Gly Ser Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Thr Leu 690 695 700 Pro Phe Lys Gin Ile Ile Gin Lys Ser Gin Val Val Gly Asp Val Asp 705 710 715 720 Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Asn Arg Gly Arg Ser Gin Ser Gin Gin Arg Leu Lys Lys 770 775 780 Leu Gin Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 785 790 795 800 Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gin Asn 805 810 815 Asp Gin Leu Phe Leu Tyr Tyr Ile Gin Asn Gly Lys Asp Met Tyr Thr 820 825 830 Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 835 840 845 Ile Ile Pro Gin Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 850 855 860 Leu Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser 865 870 875 880 Leu Asp Ile Val Arg Ala Arg Lys Ala Glu Trp Val Arg Leu Tyr Lys 885 890 895 Ser Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 900 905 910 Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gin Page 1007 of 3790 Page 1008 of 3790 Glu Glu 1370 205 1044 PRT Page 1009 of 3790 Nitrosomonas sp. 205 Met Leu His Lys Met Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr 15 10 15 Ser Leu Gly Trp Ala Met Val Arg Leu Asn Ala Asn Gin Gin Pro Cys 20 25 30 Ala Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asn Gly Arg Asn Pro 35 40 45 Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Glu Ala Arg Ser Met 50 55 60 Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Ala Arg Met Met Arg 65 70 75 80 Thr Leu Ile Glu Tyr Gly Phe Phe Pro Ala Asn Glu Thr Gin Arg Lys 85 90 95 Ala Leu Glu Asn Leu Asn Pro Tyr Ala Leu Arg Ala Lys Gly Leu Asp 100 105 110 Glu Ala Leu Thr Pro Ser Glu Phe Ala Arg Ala Leu Phe His Ile Asn 115 120 125 Gin Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Ser 130 135 140 Asp Ser Gly Ala Leu Lys Thr Ala Ile Lys Gin Leu His Ser Val Leu 145 150 155 160 Asp Pro Gin Gly Asn Asp Gly Lys Pro Arg Thr Val Gly Glu Leu Leu 165 170 175 Tyr Lys Arg Phe Thr Asp Leu Ser Lys Leu Pro Lys Asp Arg Thr Val 180 185 190 Arg Ala Arg Tyr Arg Gin Asp Lys Ile Val Lys Asp Asp Gly Lys Thr 195 200 205 Lys Ile Asp Lys Tyr Tyr Asp Leu Tyr Ile Asp Arg Ala Met Ile Glu 210 215 220 Gin Glu Phe Asp Ala Leu Trp Lys Lys Gin Ser Glu Leu Asn Pro Ile 225 230 235 240 Page 1010 of 3790 Leu Phe Thr Glu Asn Ala Arg Ala Asp Leu Lys Asp Val Leu Leu Tyr 245 250 255 Gin Arg Ser Leu Lys Pro Val Lys Pro Gly Arg Cys Thr Phe Met Ser 260 265 270 Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser Thr Gin Arg Phe Arg 275 280 285 Met Tyr Gin Glu Val Asn Asn Leu Arg Ile Leu Arg Glu Gly Leu Lys 290 295 300 Glu Glu Ser Leu Thr Leu Gin Gin Arg Asp Asp Leu Ile Asn Ala Leu 305 310 315 320 Glu Lys Asn Asn Arg Arg Thr Phe Thr Gin Ile Lys Lys Leu Leu Gly 325 330 335 Val Gly Gly Ser Val Gin Phe Asn Phe Glu Asp Pro Lys Arg Glu Glu 340 345 350 Leu Lys Gly Asn Thr Thr Ser Ala Ile Leu Gly Lys Ser Glu His Phe 355 360 365 Gly Glu Ala Trp Phe Ala Phe Asn Glu Ala Lys Gin Asp Ala Ile Val 370 375 380 Leu Gin Leu Ile Lys Glu Glu Asn Glu Ala Lys Leu Val Arg Trp Leu 385 390 395 400 Gin Asp Glu Thr Gly Ile Asp Glu Lys Arg Ala Glu Val Ile Ala Asn 405 410 415 Ala Gly Leu Pro Glu Gly Tyr Gly Ser Leu Cys Ile Glu Ala Leu Ala 420 425 430 Arg Ile Leu Pro Glu Leu Arg Arg Asp Val Val Thr Tyr Asp Lys Ala 435 440 445 Val Gin Ala Ala Gly Phe Glu His His Ser Lys Leu Asn Arg Asn Glu 450 455 460 Glu Ile Pro Asp Ile Thr Phe Lys Ile Glu Ser Ile Asp Arg Asn Ser 465 470 475 480 Gly Glu Ile Lys Gin Phe His Leu His Lys Glu Leu Pro Tyr Tyr Gly 485 490 495 Page 1011 of 3790 Glu Tyr Leu Gin Arg His Val Gly Phe Gly Ser Gly Lys Pro Glu Asp 500 505 510 Ser Ile Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 515 520 525 Gly Leu Asn Gin Val Arg Val Val Val Asn Ala Leu Ile Lys Arg Tyr 530 535 540 Gly His Pro Ser Glu Ile Ile Val Glu Val Ala Arg Asp Leu Lys Gin 545 550 555 560 Ser Lys Asp Arg Arg Asp Glu Glu Asn Lys Arg Gin Ala Glu Asn Gin 565 570 575 Lys Arg Asn Glu Arg Leu Arg Lys Asp Ile Ala Asp Ile Leu Gly Ile 580 585 590 Ser Glu Glu Arg Val Arg Arg Asp Asp Ile Glu Lys Met Ile Leu Trp 595 600 605 Glu Glu Leu Ser Phe Asp Pro Ala Asp Arg Arg Cys Pro Tyr Ser Gly 610 615 620 Val Gin Val Ser Thr Val Met Leu Leu Ser Asp Glu Val Glu Val Glu 625 630 635 640 His Ile Leu Pro Phe Ser Gin Thr Leu Asp Asp Ser Leu Asn Asn Lys 645 650 655 Thr Val Ala Leu Arg Gin Ala Asn Arg Ile Lys Gly Asn Arg Thr Pro 660 665 670 Trp Glu Ala Phe Gly Thr Ser Asn Ile Ser Gly Phe Asp Tyr Ser Gly 675 680 685 Ile Leu Thr Arg Ala Glu Leu Met Pro Lys Ala Lys Arg Tyr Arg Phe 690 695 700 Ala Glu Asp Gly Tyr Gin Arg Trp Leu Lys Asp Asp Ala Gly Phe Leu 705 710 715 720 Ala Arg Ala Leu Asn Asp Thr Arg His Leu Ser Lys Ile Ala Arg Glu 725 730 735 Tyr Met Ser Leu Ile Cys Pro Asn Thr Arg Val Ile Pro Gly Gin Met Page 1013 of 3790 Ala Leu Ala Asp Val Thr Glu Ala Asn Val Asp Ala Arg Thr Arg Thr 995 1000 1005 1040 206 1045 PRT Acidovorax avenae 206 Page 1014 of 3790 Gin Met His Glu Ser Gly Cys Arg Thr Val Gly Glu Trp Phe Trp Lys 165 170 175 Val Arg Met Glu Arg Lys Pro Glu Gly Val Lys Gly Gin Gly Val Arg 180 185 190 Ala Arg Tyr Arg Glu Thr Pro Phe Thr Thr Asp Glu Gly Lys Lys Arg 195 200 205 Ile Asp Lys Arg Tyr Asp Leu Tyr Val Asp Arg Ala Met Val Ala Gin 210 215 220 Glu Phe Asp Ala Leu Trp Ala Ala Gin Ala Thr Phe Ala Pro Ala Leu 225 230 235 240 Phe Asn Glu Ala Ala Arg Ala Glu Leu Arg Asp Ile Leu Leu His Gin 245 250 255 Arg Lys Leu Arg Pro Val Gin Pro Gly Arg Cys Thr Leu Val Pro Glu 260 265 270 Glu Pro Arg Ala Leu Leu Ala Leu Pro Ser Thr Gin Arg Phe Arg Ile 275 280 285 Tyr Gin Glu Val Asn His Leu Arg Val Leu His Asp Glu Leu Arg Glu 290 295 300 Glu Ala Leu Thr Leu Ala Gin Arg Asp Gin Ile Val Ala Leu Leu Glu 305 310 315 320 Arg Gin Ala Lys Val Thr Phe Thr Ala Met Arg Lys Ala Leu Gly Phe 325 330 335 Ser Ala Leu Phe Asn Leu Glu Asp Ala Lys Arg Asp Gly Leu Lys Gly 340 345 350 Asn Ala Thr Thr Ala Ala Leu Gly Lys Lys Asp Leu Phe Gly Pro Leu 355 360 365 Trp Ala Gly Phe Asp Thr Ala Leu Gin Asp Glu Ile Val Thr Gin Leu 370 375 380 Met Thr Glu Glu Ser Glu Pro Arg Leu Ile Ala Trp Leu Gin Glu His 385 390 395 400 Thr Gly Val Asp Glu Ala Arg Ala Gin Ala Ile Ala Asn Ala Gly Leu 405 410 415 Page 1015 of 3790 Pro Glu Gly Tyr Gly Ser Leu Gly Arg Thr Ala Leu Ala Arg Ile Val 420 425 430 Pro Glu Leu Gin Arg Asp Val Ile Thr Tyr Asp Lys Ala Val Gin Ala 435 440 445 Ala Gly Phe Ala His His Ser Asp Leu Gly Phe Ser Phe Glu His Asp 450 455 460 Ala Asp Glu Val Glu Arg Ile Gly Glu Arg Thr Ile Ala Ser Thr Gly 465 470 475 480 Glu Ile Lys Pro Val Phe Ala Phe Lys Gin Leu Pro Tyr Tyr Gly Arg 485 490 495 Ala Leu Gin Arg His Val Ala Phe Ala Lys Glu Asn Pro Arg Asn Asp 500 505 510 Glu Glu Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu 515 520 525 Asn Gin Val Arg Val Val Val Asn Ala Leu Met Cys Arg Tyr Gly Arg 530 535 540 Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gin Ser Arg 545 550 555 560 Glu Gin Lys Leu Glu Ala Gin Gin Arg Gin Ala Asp Asn Gin Lys Arg 565 570 575 Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile Ser Glu 580 585 590 Glu Arg Val Arg Thr Leu Asp Ile Gin Lys Trp Ile Leu Trp Glu Glu 595 600 605 Leu Ser His Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly Val Gin 610 615 620 Ile Ser Ala Ser Met Leu Leu Gly Glu Arg Val Glu Ile Glu His Ile 625 630 635 640 Leu Pro Phe Ser Met Thr Leu Asp Asp Ser Leu Asn Asn Arg Thr Val 645 650 655 Ala Leu Arg Glu Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro Trp Asp 660 665 670 Page 1016 of 3790 Ala Arg Thr Asp Phe Glu Ala His Gly Trp Ser Tyr Asp Gly Ile Leu 675 680 685 Gin Arg Ala Glu Arg Met Pro Gin Arg Lys Arg His Arg Phe Ala Pro 690 695 700 Asp Gly Tyr Glu Arg Trp Leu Gly Glu Asp Lys Asp Phe Leu Ala Arg 705 710 715 720 Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu Tyr Leu 725 730 735 Arg Leu Val Cys Pro Gly Ser Ala Thr Arg Val Ile Pro Gly Gin Met 740 745 750 Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 755 760 765 Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 770 775 780 Cys Val Ile Gly Val Thr Asp Gin Arg Met Met Gin Arg Phe Ala Gin 785 790 795 800 Ala Asn Ala Gin Ala Arg Glu Asp Gly Leu Thr Arg Leu Val Glu Asp 805 810 815 Met Pro Leu Pro Trp Pro Thr Tyr Arg Ala His Val Glu Arg Ala Val 820 825 830 Arg His Ile Trp Val Ser His Lys Pro Asp His Gly Phe Glu Gly Ala 835 840 845 Met Met Glu Glu Thr Ser Tyr Gly Ile Leu Arg Asp Gly Thr Ile Lys 850 855 860 Gin Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Ile Ser Arg Leu 865 870 875 880 Ile Arg Ile Thr Glu Pro Ser Gin Pro Gin Arg His Gly Val Asp Ala 885 890 895 Glu Gly Arg Pro Leu Pro Tyr Lys Gly Tyr Val Gly Gly Ser Asn Tyr 900 905 910 Cys Leu Glu Ile Thr Val Asn Asp Lys Gly Lys Trp Glu Gly Gin Val Page 1017 of 3790 Asn Glu Ala Phe Ala Tyr Thr Ser Lys Ile Ala Gly Ser Phe Gin 1010 1015 1020 Lys Thr Lys Ala Arg Gin Val Thr Ile Ser Pro Ile Gly Glu Leu Ile Gly Thr Ile Phe Tyr Lys Arg Pro Leu Arg Ser Gin Arg Gly Asn Page 1019 of 3790 Ala Gin Val Gly Tyr Glu Lys Gin Ile Asn Asn Ile Val Asn Ala Leu 340 345 350 Ile Ala Lys Tyr Lys Ser Ala Ser Glu Glu Tyr Arg Phe Ala Asp His 355 360 365 Asn Tyr Glu Tyr Gin Leu Asp Lys Ser Asp Glu Lys Asp Ile Ile Lys 370 375 380 Gin Ile Glu Ser Asn Ile Gly Thr Arg Lys Trp Ser Leu Leu Asp Ala 385 390 395 400 Asp Glu Gin Thr Asp Ile Leu Gin Lys Val Arg Asp Lys Tyr Gin Asn 405 410 415 Phe Phe Arg Ser His Glu Arg Lys Phe Val Glu Ser Pro Lys Leu Gly 420 425 430 Glu Cys Phe Glu Glu Tyr Leu Met Lys Lys Phe Pro Met Val Glu Gly 435 440 445 Glu Gin Trp Lys Lys Leu Tyr His Pro Ser Gin Ile Ala Ile Tyr Arg 450 455 460 Pro Val Ser Ala Gly Lys Asp Arg Ser Ala Leu Arg Leu Gly Asn Pro 465 470 475 480 Asp Ile Gly Ala Ile Lys Asn Pro Thr Val Leu Arg Val Leu Asn Thr 485 490 495 Leu Arg Lys Arg Val Asn Gin Leu Leu Asp Asp Gly Leu Ile Ser Pro 500 505 510 Asp Glu Thr Arg Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala 515 520 525 Asn Arg Lys Trp Ala Leu Asp Asn Tyr Asn Arg Ile Arg His Asp Glu 530 535 540 Asn Glu Lys Ile Lys Lys Ile Leu Glu Glu Phe Tyr Pro Lys Arg Asp 545 550 555 560 Gly Ile Ser Thr Asp Asp Ile Asp Lys Ala Arg Tyr Val Ile Asp Gin 565 570 575 Arg Glu Met Asp Tyr Phe Thr Glu Glu Lys Pro Tyr Asn Lys Asp Ile 580 585 590 Page 1020 of 3790 Lys Lys Tyr Lys Leu Trp Leu Glu Gin Gly Gly Gin Cys Met Tyr Thr 595 600 605 Gly Arg Thr Ile Asn Leu Ser Asn Leu Phe Asp Pro Asn Ser Phe Asp 610 615 620 Val Glu His Thr Ile Pro Glu Ser Ile Ser Phe Asp Ser Ser Asp Met 625 630 635 640 Asn Leu Thr Leu Cys Asp Ala His Tyr Asn Arg Phe Ile Lys Lys Asn 645 650 655 His Ile Pro Ala Asp Leu Pro Asn Tyr Asp Lys Ser Val Val Ile Asp 660 665 670 Gly Lys Glu Tyr Ser Pro Ile Lys Pro Arg Leu Gin Arg Trp Ala Asp 675 680 685 Arg Val Glu Arg Leu Asn Arg Asn Val Glu Tyr Trp Arg Gly Gin Ala 690 695 700 Arg Arg Ala Gin Asn Lys Asp Arg Lys Asp Gin Cys Met Arg Glu Met 705 710 715 720 His Leu Trp Lys Met Glu Leu Glu Tyr Trp Thr Lys Lys Leu Glu Arg 725 730 735 Phe Thr Ile Thr Glu Val Thr Asp Glu Phe Lys Asn Ser Gin Leu Val 740 745 750 Asp Thr Arg Val Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile 755 760 765 Phe Pro His Val Asp Val Gin Arg Gly Asp Val Thr Ala Lys Phe Arg 770 775 780 Lys Ile Leu Gly Ile Gin Ser Val Asp Glu Lys Lys Asp Arg Ser Leu 785 790 795 800 His Ser His His Ala Ile Asp Ala Thr Thr Leu Thr Ile Ile Pro Gly 805 810 815 Ala Ala Lys Arg Glu Arg Met Leu Glu Leu Phe Ala Lys Ile Glu Glu 820 825 830 Val Asn Lys Met Leu Ser Phe Ser Gly Asn Glu Asp Arg Thr Gly Leu 835 840 845 Page 1021 of 3790 Phe Lys Ile Tyr Ser Leu Tyr Asp Ile Ser Cys His Arg Lys Val 208 1458 PRT Fluviicola taffensis 208 Leu His Arg Val Leu Asn Ile Ile Gly Phe Leu Pro Glu His Tyr Ala Ile Arg Gly Lys Leu Ile Ser Thr Ile Glu Arg Lys Phe Tyr Lys Glu 325 330 335 Page 1024 of 3790 Glu Leu Lys Thr Ile Leu Lys Thr Gin Leu Phe Phe His Lys Glu Leu 340 345 350 Lys Asp Glu Lys Leu Tyr Asn Ala Cys Ile Glu Glu Leu Tyr Lys Asn 355 360 365 Asn Glu Ala His Arg Ser Leu Leu Ser Asn Lys Gly Phe Glu His Leu 370 375 380 Phe Ile Asn Asp Ile Leu Phe Tyr Gin Arg Pro Leu Arg Ser Lys Lys 385 390 395 400 Ser Gin Ile Ser Asn Cys Pro Leu Glu Lys Arg Thr Tyr Lys Lys Glu 405 410 415 Gly Ile Glu Ile Thr Glu Gly Ile Lys Val Ile Ser Lys Ser Asn Pro 420 425 430 Ile Tyr Gin Glu Phe Arg Leu Trp Gin Trp Ile Ser Asn Leu Ser Leu 435 440 445 Tyr Cys Ile Glu Pro Thr Glu Thr Asn Val Thr Ser Thr Phe Leu Asn 450 455 460 Ser Ile Glu Asp Tyr Glu Asn Leu Phe Glu Phe Leu Asn Asn Arg Lys 465 470 475 480 Glu Ile Glu Gin Lys His Leu Leu Lys Tyr Leu Leu Glu Asn Gin Gly 485 490 495 Phe Lys Gly Lys Leu Leu Thr Asn Glu Leu Glu Lys Phe Arg Trp Asn 500 505 510 Phe Val Ala Asp Lys Lys Tyr Pro Cys Asn Glu Thr Gly Ser Leu Leu 515 520 525 His Thr Arg Leu Ser Lys Val Lys Asn Ile Ser Pro Asp Phe Leu Thr 530 535 540 Lys Glu Ile Glu His Gin Leu Trp His Ile Ile Tyr Ser Val Thr Asp 545 550 555 560 Lys Ile Glu Tyr Glu Gin Ala Leu Lys Thr Phe Ala Arg Lys Asn Asn 565 570 575 Leu Asp Val Asp Ser Phe Phe Glu His Phe Lys Lys Ile Pro Pro Phe 580 585 590 Page 1025 of 3790 Glu Ser Thr Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu 595 600 605 Pro Leu Ile Arg Leu Gly Lys Tyr Trp Asn Trp Glu Ala Ile Asp Ser 610 615 620 Ile Ser Lys Asp Arg Ile Ser Lys Ile Leu Ser Gly Glu Tyr Asp Glu 625 630 635 640 Asn Ile Lys Asn Arg Val Arg Glu Lys Ala Val His Leu Thr Ser Glu 645 650 655 Asn Asn Phe Gin Gly Leu Gin Glu Trp Leu Ala Lys Tyr Ile Val Tyr 660 665 670 Asp Arg His Ser Glu Gly Asn Asp Leu Gly Lys Trp Thr Ser Val Ser 675 680 685 Asp Leu Glu Thr Tyr Leu Lys Glu Phe Lys Gin His Ser Leu Arg Asn 690 695 700 Pro Ile Val Glu Gin Val Ile Thr Glu Thr Leu Arg Val Val Lys Asp 705 710 715 720 Ile Trp Ile Lys His Gly Lys Gly Thr Glu Asn Phe Phe Asp Glu Ile 725 730 735 His Val Glu Leu Gly Arg Glu Met Lys Asn Asn Ser Glu Asp Arg Lys 740 745 750 Arg Leu Thr Asn Thr Ile Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile 755 760 765 Lys Ala Leu Leu Met Glu Met Met Asn Asp Asn Asp Val Glu Asn Val 770 775 780 Arg Pro Tyr Ser Pro Ser Gin Gin Glu Ile Leu Lys Ile Tyr Glu Asp 785 790 795 800 Gly Ala Leu Asn Ser Asn Ile Glu Leu Asp Asp Glu Ile Val Lys Ile 805 810 815 Ser Lys Lys Ala Glu Pro Thr Lys Ser Glu Leu Gin Arg Tyr Lys Leu 820 825 830 Trp Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Gin Val Ile Pro 835 840 845 Page 1026 of 3790 Leu Lys Arg Tyr Asp Leu Gin Asn Lys Leu Arg Lys Lys Glu Pro Page 1028 of 3790 209 1384 PRT Coriobacterium glomerans 209 Met Lys Leu Arg Gly Ile Glu Asp Asp Tyr Ser Ile Gly Leu Asp Met 15 10 15 Gly Thr Ser Ser Val Gly Trp Ala Val Thr Asp Glu Arg Gly Thr Leu 20 25 30 Ala His Phe Lys Arg Lys Pro Thr Trp Gly Ser Arg Leu Phe Arg Glu 35 40 45 Ala Gin Thr Ala Ala Val Ala Arg Met Pro Arg Gly Gin Arg Arg Arg 50 55 60 Tyr Val Arg Arg Arg Trp Arg Leu Asp Leu Leu Gin Lys Leu Phe Glu 65 70 75 80 Page 1029 of 3790 Gin Gin Met Glu Gin Ala Asp Pro Asp Phe Phe Ile Arg Leu Arg Gin 85 90 95 Ser Arg Leu Leu Arg Asp Asp Arg Ala Glu Glu His Ala Asp Tyr Arg 100 105 110 Trp Pro Leu Phe Asn Asp Cys Lys Phe Thr Glu Arg Asp Tyr Tyr Gin 115 120 125 Arg Phe Pro Thr Ile Tyr His Val Arg Ser Trp Leu Met Glu Thr Asp 130 135 140 Glu Gin Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu His Asn Ile Val 145 150 155 160 Lys His Arg Gly Asn Phe Leu Arg Glu Gly Gin Ser Leu Ser Ala Lys 165 170 175 Ser Ala Arg Pro Asp Glu Ala Leu Asn His Leu Arg Glu Thr Leu Arg 180 185 190 Val Trp Ser Ser Glu Arg Gly Phe Glu Cys Ser Ile Ala Asp Asn Gly 195 200 205 Ser Ile Leu Ala Met Leu Thr His Pro Asp Leu Ser Pro Ser Asp Arg 210 215 220 Arg Lys Lys Ile Ala Pro Leu Phe Asp Val Lys Ser Asp Asp Ala Ala 225 230 235 240 Ala Asp Lys Lys Leu Gly Ile Ala Leu Ala Gly Ala Val Ile Gly Leu 245 250 255 Lys Thr Glu Phe Lys Asn Ile Phe Gly Asp Phe Pro Cys Glu Asp Ser 260 265 270 Ser Ile Tyr Leu Ser Asn Asp Glu Ala Val Asp Ala Val Arg Ser Ala 275 280 285 Cys Pro Asp Asp Cys Ala Glu Leu Phe Asp Arg Leu Cys Glu Val Tyr 290 295 300 Ser Ala Tyr Val Leu Gin Gly Leu Leu Ser Tyr Ala Pro Gly Gin Thr 305 310 315 320 Ile Ser Ala Asn Met Val Glu Lys Tyr Arg Arg Tyr Gly Glu Asp Leu 325 330 335 Page 1030 of 3790 Ala Leu Leu Lys Lys Leu Val Lys Ile Tyr Ala Pro Asp Gin Tyr Arg 340 345 350 Met Phe Phe Ser Gly Ala Thr Tyr Pro Gly Thr Gly Ile Tyr Asp Ala 355 360 365 Ala Gin Ala Arg Gly Tyr Thr Lys Tyr Asn Leu Gly Pro Lys Lys Ser 370 375 380 Glu Tyr Lys Pro Ser Glu Ser Met Gin Tyr Asp Asp Phe Arg Lys Ala 385 390 395 400 Val Glu Lys Leu Phe Ala Lys Thr Asp Ala Arg Ala Asp Glu Arg Tyr 405 410 415 Arg Met Met Met Asp Arg Phe Asp Lys Gin Gin Phe Leu Arg Arg Leu 420 425 430 Lys Thr Ser Asp Asn Gly Ser Ile Tyr His Gin Leu His Leu Glu Glu 435 440 445 Leu Lys Ala Ile Val Glu Asn Gin Gly Arg Phe Tyr Pro Phe Leu Lys 450 455 460 Arg Asp Ala Asp Lys Leu Val Ser Leu Val Ser Phe Arg Ile Pro Tyr 465 470 475 480 Tyr Val Gly Pro Leu Ser Thr Arg Asn Ala Arg Thr Asp Gin His Gly 485 490 495 Glu Asn Arg Phe Ala Trp Ser Glu Arg Lys Pro Gly Met Gin Asp Glu 500 505 510 Pro Ile Phe Pro Trp Asn Trp Glu Ser Ile Ile Asp Arg Ser Lys Ser 515 520 525 Ala Glu Lys Phe Ile Leu Arg Met Thr Gly Met Cys Thr Tyr Leu Gin 530 535 540 Gin Glu Pro Val Leu Pro Lys Ser Ser Leu Leu Tyr Glu Glu Phe Cys 545 550 555 560 Val Leu Asn Glu Leu Asn Gly Ala His Trp Ser Ile Asp Gly Asp Asp 565 570 575 Glu His Arg Phe Asp Ala Ala Asp Arg Glu Gly Ile Ile Glu Glu Leu 580 585 590 Page 1031 of 3790 Phe Arg Arg Lys Arg Thr Val Ser Tyr Gly Asp Val Ala Gly Trp Met 595 600 605 Glu Arg Glu Arg Asn Gin Ile Gly Ala His Val Cys Gly Gly Gin Gly 610 615 620 Glu Lys Gly Phe Glu Ser Lys Leu Gly Ser Tyr Ile Phe Phe Cys Lys 625 630 635 640 Asp Val Phe Lys Val Glu Arg Leu Glu Gin Ser Asp Tyr Pro Met Ile 645 650 655 Glu Arg Ile Ile Leu Trp Asn Thr Leu Phe Glu Asp Arg Lys Ile Leu 660 665 670 Ser Gin Arg Leu Lys Glu Glu Tyr Gly Ser Arg Leu Ser Ala Glu Gin 675 680 685 Ile Lys Thr Ile Cys Lys Lys Arg Phe Thr Gly Trp Gly Arg Leu Ser 690 695 700 Glu Lys Phe Leu Thr Gly Ile Thr Val Gin Val Asp Glu Asp Ser Val 705 710 715 720 Ser Ile Met Asp Val Leu Arg Glu Gly Cys Pro Val Ser Gly Lys Arg 725 730 735 Gly Arg Ala Met Val Met Met Glu Ile Leu Arg Asp Glu Glu Leu Gly 740 745 750 Phe Gin Lys Lys Val Asp Asp Phe Asn Arg Ala Phe Phe Ala Glu Asn 755 760 765 Ala Gin Ala Leu Gly Val Asn Glu Leu Pro Gly Ser Pro Ala Val Arg 770 775 780 Arg Ser Leu Asn Gin Ser Ile Arg Ile Val Asp Glu Ile Ala Ser Ile 785 790 795 800 Ala Gly Lys Ala Pro Ala Asn Ile Phe Ile Glu Val Thr Arg Asp Glu 805 810 815 Asp Pro Lys Lys Lys Gly Arg Arg Thr Lys Arg Arg Tyr Asn Asp Leu 820 825 830 Lys Asp Ala Leu Glu Ala Phe Lys Lys Glu Asp Pro Glu Leu Trp Arg Page 1032 of 3790 Arg Cys Arg Thr Ile Pro Gly Ser Ser Gly Phe Ile Val Asn Ser 1070 1075 1080 Page 1034 of 3790 Leu 210 1077 PRT Neisseria bacilliformis 210 Met Gin Gin Lys Pro Gin Arg Tyr 1 5 Ile Leu Gly Leu Asp Leu Gly Ile 10 15 Ala Ser Val Gly Trp Ala Cys Val 20 Trp Ala Asp Glu Asn Glu His Pro 25 30 Thr Gly Leu Leu Asp Cys Gly Val 35 40 Arg Thr Phe Glu Arg Ala Glu Val 45 Pro Lys Thr Gly Asp Ser Leu Ala 50 55 Leu Ala Arg Arg Gin Ala Arg Ser 60 Val Arg Arg Leu Ile Arg Arg Arg 65 70 Ala His Arg Leu Leu Arg Leu Arg 75 80 Arg Leu Leu Lys Arg Glu Gly Val 85 Leu Leu Ser Ala Asp Phe Asn Glu 90 95 Asn Gly Leu Val Arg Gly Leu Pro 100 Ile Asp Ala Trp Ala Leu Arg Val 105 110 Ala Gly Leu Asp Arg Lys Leu Ser 115 120 Asn Lys Glu Trp Ala Ala Val Leu 125 Leu His Leu Val Lys His Arg Gly Tyr Leu Ser Gin Arg Lys Asn Glu 130 135 140 Page 1035 of 3790 Thr Gin Ser Lys Asp Lys Glu Leu Gly Arg Leu Leu Ala Gly Val Asn 145 150 155 160 Gly Asn Arg Glu Ala Leu Gin Asn Arg Ser Asp Glu Tyr Arg Thr Ala 165 170 175 Ala Glu Leu Ala Val Lys Lys Phe Ala Ala Glu Asn Asn Gly Ser Leu 180 185 190 Arg Asn Lys Gly Gly Asp Tyr Ser His Thr Phe Asp Arg Lys Asp Leu 195 200 205 Gin Arg Glu Leu His Leu Leu Phe Glu Arg Gin Arg Ala Leu Asp Asn 210 215 220 Pro Phe Thr Ser Ser Glu Met Glu Ala Ala Val Asp Glu Leu Leu Met 225 230 235 240 Lys Gin Arg Ser Ala Leu Gin Gly Glu Ala Val Leu Lys Met Leu Gly 245 250 255 Arg Cys Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Ser Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Gin Tyr Asn Gly Glu Glu Arg Ala Leu Ser Glu Ala Glu Arg Arg Leu 290 295 300 Leu Leu Asp Glu Pro Tyr Gin Lys Ala Lys Leu Thr Tyr Lys Gin Val 305 310 315 320 Arg Thr Ile Leu Glu Leu Pro Glu Ser Ala Val Phe Lys Gly Leu Arg 325 330 335 Tyr Gly His Gly Glu Asp Gly Leu Lys Ala Glu Ser Gly Thr Leu Met 340 345 350 Glu Met Lys Ala Tyr His Ala Val Arg Lys Ala Leu Lys Asp Ala Gly 355 360 365 Leu Glu Gly Glu Trp Glu Asn Arg Ile Arg Asn Pro Glu Leu Leu Asp 370 375 380 Ala Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Glu Asp Ile Arg 385 390 395 400 Page 1036 of 3790 Ala Asn Leu Ala Ala Phe Arg Leu Ser Glu Asn Val Leu Glu Ala Leu 405 410 415 Leu Ala Gly Leu Asn Phe Asp Lys Phe Val His Leu Ser Leu Lys Ala 420 425 430 Leu Ala Lys Ile Leu Pro Leu Met Glu Gin Gly Met Arg Tyr Asp Glu 435 440 445 Ala Cys Lys Glu Ala Tyr Gly Asp His Tyr Gly Ala Lys Glu Gin Glu 450 455 460 Asp His Arg Leu Leu Pro Pro Phe Val Ala Asp Asp Ile Arg Asn Pro 465 470 475 480 Val Val Phe Arg Thr Leu Thr Gin Ala Arg Lys Ile Val Asn Glu Ile 485 490 495 Val Arg Arg Tyr Gly Ser Pro Leu Arg Val His Ile Glu Thr Gly Arg 500 505 510 Glu Val Gly Lys Ser Phe Ser Asp Arg Lys Glu Ile Glu Lys Arg Gin 515 520 525 Glu Glu Asn Arg Lys Glu Arg Glu Arg Ala Ala Ala His Phe Lys Glu 530 535 540 Leu Phe Pro Asn Phe Ala Gly Glu Pro Lys Ala Gin Asp Ile Leu Lys 545 550 555 560 Leu Arg Leu Tyr Glu Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys 565 570 575 Glu Ile Asp Leu Arg Arg Leu Pro Glu Lys Gly Tyr Val Glu Ile Asp 580 585 590 His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys 595 600 605 Val Leu Val Leu Gly Lys Glu Asn Gin Asp Lys Arg Asn Arg Thr Pro 610 615 620 Tyr Glu Tyr Leu Asp Gly Lys Gly Asn Ser Gly Ala Trp Arg Ala Phe 625 630 635 640 Ala Glu Arg Val Ser Gly Cys Arg Phe Pro Tyr Ala Lys Lys Gin Arg Page 1038 of 3790 Ser Leu Tyr Pro Asn Asp Leu Val Glu Val Val Thr Lys Lys Asp Lys 995 1000 1005 211 1029 PRT Alicycliphilus denitrificans 211 Met Arg Ser Leu Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr Ser 15 10 15 Leu Gly Trp Ala Leu Phe Arg Leu Asp Ala Cys Asn Arg Pro Thr Ala 20 25 30 Page 1039 of 3790 Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys 35 40 45 Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Ala Ala Arg Ala Met Arg 50 55 60 Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Thr Arg Met Gin Ala Lys 65 70 75 80 Leu Val Glu His Gly Phe Phe Pro Ala Asp Ala Gly Lys Arg Lys Ala 85 90 95 Leu Glu Gin Leu Asn Pro Tyr Ala Leu Arg Ala Lys Gly Leu Gin Glu 100 105 110 Ala Leu Leu Pro Gly Glu Phe Ala Arg Ala Leu Phe His Ile Asn Gin 115 120 125 Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Asn Asp 130 135 140 Ser Gly Val Leu Lys Lys Ala Ile Gly Gin Leu Arg Gin Gin Met Ala 145 150 155 160 Glu Gin Gly Ser Arg Thr Val Gly Glu Tyr Leu Trp Thr Arg Leu Gin 165 170 175 Gin Gly Gin Gly Val Arg Ala Arg Tyr Arg Glu Lys Pro Tyr Thr Thr 180 185 190 Glu Glu Gly Lys Lys Arg Ile Asp Lys Ser Tyr Asp Leu Tyr Ile Asp 195 200 205 Arg Ala Met Ile Glu Gin Glu Phe Asp Ala Leu Trp Ala Ala Gin Ala 210 215 220 Ala Phe Asn Pro Thr Leu Phe His Glu Ala Ala Arg Ala Asp Leu Lys 225 230 235 240 Asp Thr Leu Leu His Gin Arg Pro Leu Arg Pro Val Lys Pro Gly Arg 245 250 255 Cys Thr Leu Leu Pro Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser 260 265 270 Thr Gin Arg Phe Arg Ile His Gin Glu Val Asn His Leu Arg Leu Leu 275 280 285 Page 1040 of 3790 Asp Glu Asn Leu Arg Glu Val Ala Leu Thr Leu Ala Gin Arg Asp Ala 290 295 300 Val Val Thr Ala Leu Glu Thr Lys Ala Lys Leu Ser Phe Glu Gin Ile 305 310 315 320 Arg Lys Leu Leu Lys Leu Ser Gly Ser Val Gin Phe Asn Leu Glu Asp 325 330 335 Ala Lys Arg Thr Glu Leu Lys Gly Asn Ala Thr Ser Ala Ala Leu Ala 340 345 350 Arg Lys Glu Leu Phe Gly Ala Ala Trp Ser Gly Phe Asp Glu Ala Leu 355 360 365 Gin Asp Glu Ile Val Trp Gin Leu Val Thr Glu Glu Gly Glu Gly Ala 370 375 380 Leu Ile Ala Trp Leu Gin Thr His Thr Gly Val Asp Glu Ala Arg Ala 385 390 395 400 Gin Ala Ile Val Asp Val Ser Leu Pro Glu Gly Tyr Gly Asn Leu Ser 405 410 415 Arg Lys Ala Leu Ala Arg Ile Val Pro Ala Leu Arg Ala Ala Val Ile 420 425 430 Thr Tyr Asp Lys Ala Val Gin Ala Ala Gly Phe Asp His His Ser Gin 435 440 445 Leu Gly Phe Glu Tyr Asp Ala Ser Glu Val Glu Asp Leu Val His Pro 450 455 460 Glu Thr Gly Glu Ile Arg Ser Val Phe Lys Gin Leu Pro Tyr Tyr Gly 465 470 475 480 Lys Ala Leu Gin Arg His Val Ala Phe Gly Ser Gly Lys Pro Glu Asp 485 490 495 Pro Asp Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro Thr Val His Ile 500 505 510 Gly Leu Asn Gin Val Arg Met Val Val Asn Ala Leu Ile Arg Arg Tyr 515 520 525 Gly Arg Pro Thr Glu Val Val Ile Glu Leu Ala Arg Asp Leu Lys Gin 530 535 540 Page 1041 of 3790 Ser Arg Glu Gin Lys Val Glu Ala Gin Arg Arg Gin Ala Asp Asn Gin 545 550 555 560 Arg Arg Asn Ala Arg Ile Arg Arg Ser Ile Ala Glu Val Leu Gly Ile 565 570 575 Gly Glu Glu Arg Val Arg Gly Ser Asp Ile Gin Lys Trp Ile Cys Trp 580 585 590 Glu Glu Leu Ser Phe Asp Ala Ala Asp Arg Arg Cys Pro Tyr Ser Gly 595 600 605 Val Gin Ile Ser Ala Ala Met Leu Leu Ser Asp Glu Val Glu Val Glu 610 615 620 His Ile Leu Pro Phe Ser Lys Thr Leu Asp Asp Ser Leu Asn Asn Arg 625 630 635 640 Thr Val Ala Met Arg Gin Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro 645 650 655 Trp Asp Ala Arg Ala Glu Phe Glu Ala Gin Gly Trp Ser Tyr Glu Asp 660 665 670 Ile Leu Gin Arg Ala Glu Arg Met Pro Leu Arg Lys Arg Tyr Arg Phe 675 680 685 Ala Pro Asp Gly Tyr Glu Arg Trp Leu Gly Asp Asp Lys Asp Phe Leu 690 695 700 Ala Arg Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Glu 705 710 715 720 Tyr Leu Arg Leu Val Cys Pro Gly Thr Arg Val Ile Pro Gly Gin Leu 725 730 735 Thr Ala Leu Leu Arg Gly Lys Phe Gly Leu Asn Asp Val Leu Gly Leu 740 745 750 Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala Val Asp Ala 755 760 765 Cys Val Ile Gly Val Thr Asp Gin Gly Leu Met Gin Arg Phe Ala Thr 770 775 780 Ala Ser Ala Gin Ala Arg Gly Asp Gly Leu Thr Arg Leu Val Asp Gly 800 785 790 Page 1042 of 3790 795 Asp Pro Gly Phe Lys Gly 1025 Page 1043 of 3790 212 1122 PRT Streptococcus suis 212 Met Ser Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 15 10 15 Gly Val Gly Val Ile Asp Ala Gin Thr Gly Glu Ile Ile His Ala Ser 20 25 30 Ser Arg Ile Phe Pro Ser Ala Asn Ala Ala Asn Asn Ala Glu Arg Arg 35 40 45 Thr Phe Arg Gly Ser Arg Arg Leu Ile Arg Arg Lys Lys His Arg Ile 50 55 60 Lys Arg Leu Asp Asp Leu Phe Asn Asp Phe His Ile Asn Leu Asp Gly 65 70 75 80 Glu Met Ser Thr Asp Asn Pro Tyr Val Leu Arg Val Lys Gly Leu Ser 85 90 95 Gin Lys Leu Thr Val Glu Glu Leu Tyr Ile Ser Ile Lys Asn Ile Met 100 105 110 Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Ser Asp Asn Glu 115 120 125 Ala Gly Arg Ser Asp Tyr Ala Lys Ala Ile Glu Arg Asn Arg Gin Leu 130 135 140 Leu Thr Ser Lys Thr Pro Gly Glu Ile Gin Leu Glu Arg Leu Glu Lys 145 150 155 160 Tyr Gly Gin Leu Arg Gly Asn Phe Thr Ile Ile Asp Glu Glu Gly Gin 165 170 175 Ser Gin Gin Ile Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu 180 185 190 Val Glu Lys Ile Leu Asp Cys Gin Lys Met Tyr His Lys Phe Ile Ser 195 200 205 Asp Glu Phe Cys Asp Lys Leu Ile Glu Leu Leu Arg Glu Lys Arg Lys 210 215 220 Page 1044 of 3790 Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile 225 230 235 240 Tyr Arg Thr Asp Gly Thr Thr Leu Glu Asn Leu Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Gin Tyr Arg Ser Ser Arg Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Gin Glu Gin Lys Glu Phe Leu 290 295 300 Val Asn Tyr Ala Lys Glu Thr Ser Val Leu Gly Ala Gly Lys Ile Leu 305 310 315 320 Gin Gin Ile Ala Lys Leu Ala Asp Cys Lys Val Glu Asp Ile Arg Gly 325 330 335 Tyr Arg Leu Asp Asn Lys Asp Lys Pro Glu Leu His Thr Phe Glu Thr 340 345 350 Tyr Arg Ala Met Lys Gly Leu Val Pro Leu Val Asp Ile Gly Val Leu 355 360 365 Ser Arg Glu Gin Leu Asp Ile Leu Ala Asp Ile Leu Thr Leu Asn Thr 370 375 380 Asp Phe Glu Gly Ile Arg Glu Ala Leu Lys Lys Gin Leu Pro Asn Val 385 390 395 400 Phe Asp Glu Lys Gin Val Lys Gly Leu Ala Ser Phe Arg Lys Ser Lys 405 410 415 Ser Gin Leu Phe Ala Lys Gly Trp His Asn Leu Ser Gin Lys Ile Met 420 425 430 Leu Glu Val Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gin Met Thr 435 440 445 Ile Leu Thr Arg Leu Gly Lys Phe Glu Lys Ser Ser Val Ala Glu Tyr 450 455 460 Pro Ser Ser Ile Asn Val Asp Glu Ile Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Page 1045 of 3790 Val Val Ala Lys Ser Ile Arg Gin Thr Ile Lys Ile Ile Asn Ala Ser 485 490 495 Ile Lys Lys Trp Gly Glu Phe Asp Gin Ile Val Ile Glu Met Pro Arg 500 505 510 Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gin Lys 515 520 525 Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 530 535 540 Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 545 550 555 560 Gin Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Ile Tyr Thr Gly Gin Pro Ile Ser Ile His Asp Leu Ile His Asn Gin 580 585 590 Asn Gin Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 595 600 605 Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gin Glu 610 615 620 Lys Ala Gin Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 625 630 635 640 Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 645 650 655 Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 660 665 670 Phe Glu Val Arg Ser Lys Phe Ile Gin Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gin Asp Tyr Phe Lys Ile 690 695 700 Ser Gly Ile Gin Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 725 730 735 Page 1046 of 3790 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg 740 745 750 Leu Trp Lys Lys Gin Glu Ser Pro Leu Val Val Asp Tyr Gin Glu Gly 755 760 765 Arg Gin Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 770 775 780 Gin Tyr Lys Glu Leu Val Tyr Gin Pro Pro Tyr Gin Gly Phe Val Asn 785 790 795 800 Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gin 805 810 815 Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 820 825 830 Thr Arg Asn Ala Gin Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 835 840 845 Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gin Ala Gly Tyr Glu Ala Phe 850 855 860 Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 865 870 875 880 Asp Leu Asp Thr Trp Glu Lys Val Ile Glu Ile Ile Leu Arg Asp Tyr 885 890 895 Arg Glu Tyr Asp Glu Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg 900 905 910 Tyr Arg Arg Glu Asn Gly Tyr Val Lys Lys Tyr Ser Arg Lys Gly Asn 915 920 925 Gly Thr Ala Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn 930 935 940 His Ile Asp Ile Thr Pro Glu Asn Ser Arg Asn Ala Val Val Leu Gin 945 950 955 960 Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Glu Thr Gly 965 970 975 Lys Tyr Glu Phe Leu Gly Ile Lys Tyr Ser Asp Leu Ser Phe Glu Lys 980 990 Page 1047 of 3790 985 Gly Thr Gly Glu Tyr Gly Ile Ser Gin Glu Lys Tyr Asp Ser Ile Lys 995 1000 1005 213 1428 PRT Parasutterella excrementihominis 213 Met Gly Lys Thr His Ile Ile Gly Val Gly Leu Asp Leu Gly Gly Thr 15 10 15 Tyr Thr Gly Thr Phe Ile Thr Ser His Pro Ser Asp Glu Ala Glu His 20 25 30 Arg Asp His 35 Ser Ser Ala Phe Thr Val Val Asn 40 Ser Glu Lys 45 Leu Ser Phe Ser Ser Lys 50 Ser Arg Thr Ala Val 55 Arg His Arg Val 60 Arg Ser Tyr Lys Gly Phe Asp Leu Arg Arg Arg Leu Leu Leu Leu Val Ala Glu Tyr Page 1049 of 3790 Val Leu Asp Val Leu Ala Gly Leu Asp Pro Asp Arg Thr Ile Pro Pro 325 330 335 Tyr Glu Asp Gin Asn Asn Arg Arg Pro Pro Glu Asp Gin Thr Leu Tyr 340 345 350 Leu Asn Pro Lys Ala Leu Ser Ser Glu Tyr Gly Glu Lys Trp Lys Ser 355 360 365 Trp Ala Asn Lys Phe Ala Gly Ala Tyr Pro Leu Leu Thr Glu Asp Leu 370 375 380 Thr Glu Ile Leu Lys Asn Thr Asp Arg Lys Ser Arg Ile Lys Ile Arg 385 390 395 400 Ser Asp Val Leu Pro Asp Ser Asp Tyr Arg Leu Ala Tyr Ile Leu Gin 405 410 415 Arg Ala Phe Asp Arg Ser Ile Ala Leu Asp Glu Cys Ser Ile Arg Arg 420 425 430 Thr Ala Glu Asp Phe Glu Asn Gly Val Val Ile Lys Asn Glu Lys Leu 435 440 445 Glu Asp Val Leu Ser Gly His Gin Leu Glu Glu Phe Leu Glu Phe Ala 450 455 460 Asn Arg Tyr Tyr Gin Glu Thr Ala Lys Ala Lys Asn Gly Leu Trp Phe 465 470 475 480 Pro Glu Asn Ala Leu Leu Glu Arg Ala Asp Leu His Pro Pro Met Lys 485 490 495 Asn Lys Ile Leu Asn Val Ile Val Gly Gin Ala Leu Gly Val Ser Pro 500 505 510 Ala Glu Gly Thr Asp Phe Ile Glu Glu Ile Trp Asn Ser Lys Val Lys 515 520 525 Gly Arg Ser Thr Val Arg Ser Ile Cys Asn Ala Ile Glu Asn Glu Arg 530 535 540 Lys Thr Tyr Gly Pro Tyr Phe Ser Glu Asp Tyr Lys Phe Val Lys Thr 545 550 555 560 Ala Leu Lys Glu Gly Lys Thr Glu Lys Glu Leu Ser Lys Lys Phe Ala 565 570 575 Page 1050 of 3790 Ala Val Ile Lys Val Leu Lys Met Val Ser Glu Val Val Pro Phe Ile 580 585 590 Gly Lys Glu Leu Arg Leu Ser Asp Glu Ala Gin Ser Lys Phe Asp Asn 595 600 605 Leu Tyr Ser Leu Ala Gin Leu Tyr Asn Leu Ile Glu Thr Glu Arg Asn 610 615 620 Gly Phe Ser Lys Val Ser Leu Ala Ala His Leu Glu Asn Ala Trp Arg 625 630 635 640 Met Thr Met Thr Asp Gly Ser Ala Gin Cys Cys Arg Leu Pro Ala Asp 645 650 655 Cys Val Arg Pro Phe Asp Gly Phe Ile Arg Lys Ala Ile Asp Arg Asn 660 665 670 Ser Trp Glu Val Ala Lys Arg Ile Ala Glu Glu Val Lys Lys Ser Val 675 680 685 Asp Phe Thr Asn Gly Thr Val Lys Ile Pro Val Ala Ile Glu Ala Asn 690 695 700 Ser Phe Asn Phe Thr Ala Ser Leu Thr Asp Leu Lys Tyr Ile Gin Leu 705 710 715 720 Lys Glu Gin Lys Leu Lys Lys Lys Leu Glu Asp Ile Gin Arg Asn Glu 725 730 735 Glu Asn Gin Glu Lys Arg Trp Leu Ser Lys Glu Glu Arg Ile Arg Ala 740 745 750 Asp Ser His Gly Ile Cys Ala Tyr Thr Gly Arg Pro Leu Asp Asp Val 755 760 765 Gly Glu Ile Asp His Ile Ile Pro Arg Ser Leu Thr Leu Lys Lys Ser 770 775 780 Glu Ser Ile Tyr Asn Ser Glu Val Asn Leu Ile Phe Val Ser Ala Gin 785 790 795 800 Gly Asn Gin Glu Lys Lys Asn Asn Ile Tyr Leu Leu Ser Asn Leu Ala 805 810 815 Lys Asn Tyr Leu Ala Ala Val Phe Gly Thr Ser Asp Leu Ser Gin Ile 820 825 830 Page 1051 of 3790 Ser Val Leu Gly Ala Tyr Leu Asp Lys Ala Pro Ser Ser Glu Lys Page 1053 of 3790 214 1371 PRT Lactobacillus buchneri 214 Met Lys Val Asn Asn Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser 15 10 15 Ile Gly Trp Val Ala Ile Gly Glu Asp Gly Lys Pro Leu Arg Ile Lys 20 25 30 Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Gin Glu Gly Asn Pro Ala 35 40 45 Ala Asp Arg Arg Met Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 50 55 60 Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Ile Thr 65 70 75 80 Pro Val Asp Ser Thr Phe Phe Ala Arg Leu Lys Gin Ser Asn Leu Ser 85 90 95 Page 1054 of 3790 Pro Lys Asp Ser Arg Lys Glu Phe Lys Gly Ser Met Leu Phe Pro Asp 100 105 110 Leu Thr Asp Met Gin Tyr His Lys Asp Tyr Pro Thr Ile Tyr His Leu 115 120 125 Arg His Ala Leu Met Thr Gin Asp Glu Lys Phe Asp Ile Arg Met Val 130 135 140 Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn 145 150 155 160 Ser Thr Pro Val Asp Ser Phe Lys Ala Ser Lys Val Asn Phe Val Asp 165 170 175 Gin Phe Lys Lys Leu Asn Glu Leu Tyr Thr Ala Ile Asn Pro Glu Glu 180 185 190 Ser Phe Gin Ile Asn Leu Ala Asn Ser Glu Asp Ile Gly His Gin Phe 195 200 205 Leu Asp Pro Ser Ile Arg Lys Phe Asp Lys Lys Lys Gin Ile Pro Lys 210 215 220 Ile Val Pro Val Ser Val Asp Asp Lys Ala Thr Asp Lys Ile Asn Gly 225 230 235 240 Lys Ile Ala Ser Glu Ile Ile Asn Ala Ile Leu Gly Tyr Lys Ser Lys 245 250 255 Leu Asp Val Val Val Gin Cys Thr Pro Val Asp Ser Lys Ser Trp Ala 260 265 270 Leu Lys Phe Asp Glu Glu Asp Ile Asp Ala Lys Leu Gin Lys Ile Leu 275 280 285 Pro Glu Met Asp Glu Asn Gin Gin Ser Ile Ile Ala Ile Leu Gin Asn 290 295 300 Leu Tyr Ser Gin Val Thr Leu Asn Gin Ile Val Pro Asn Gly Met Ser 305 310 315 320 Leu Ser Glu Ser Met Ile Glu Lys Tyr Asn Asp His His Asp His Leu 325 330 335 Lys Leu Tyr Lys Lys Ile Ile Asp Gin Leu Ala Asp Pro Lys Lys Lys 340 345 350 Page 1055 of 3790 Ala Ala Leu Lys Lys Ala Tyr Ser Gin Tyr Val Gly Asp Asp Gly Lys 355 360 365 Val Ile Glu Gin Ala Asp Phe Trp Ser Ser Val Lys Lys Asn Leu Asp 370 375 380 Asp Ser Asp Leu Ser Lys Gin Ile Met Asp Leu Ile Asp Ala Glu Lys 385 390 395 400 Phe Met Pro Lys Gin Arg Thr Ser Gin Asn Gly Val Ile Pro His Gin 405 410 415 Leu His Gin Arg Glu Leu Asp Glu Ile Ile Glu His Gin Ser Lys Tyr 420 425 430 Tyr Pro Trp Leu Ala Glu Ile Asn Pro Asn Lys His Asp Leu His Leu 435 440 445 Ala Lys Tyr Lys Ile Glu Glu Leu Val Ala Phe Arg Val Pro Tyr Tyr 450 455 460 Val Gly Pro Met Ile Thr Pro Asp Asp Gin Ala Lys Ser Ala Glu Thr 465 470 475 480 Val Phe Ser Trp Met Glu Arg Lys Gly Lys Glu Ala Gly Gin Ile Thr 485 490 495 Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Asn Ala Ser Ala Asn Arg 500 505 510 Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Ile Gly Glu Asp 515 520 525 Val Leu Pro Asp Glu Ser Leu Leu Tyr Glu Lys Phe Lys Val Leu Asn 530 535 540 Glu Leu Asn Met Val Arg Val Asn Gly Lys Leu Leu Lys Val Ala Asp 545 550 555 560 Lys Gin Ala Ile Phe Gin Asp Leu Phe Glu Asn Tyr Lys His Ile Ser 565 570 575 Val Lys Lys Leu Gin Asn Tyr Ile Lys Ser Lys Thr Gly Leu Pro Ser 580 585 590 Asp Pro Glu Ile Ser Gly Leu Ser Asp Pro Glu Tyr Phe Asn Asn Ser 595 600 605 Page 1056 of 3790 Leu Gly Thr Tyr Asn Asp Phe Lys Lys Leu Phe Gly Asn Lys Val Asp 610 615 620 Glu Pro Asp Leu Gin Asp Asp Phe Glu Lys Ile Val Glu Trp Ser Thr 625 630 635 640 Val Phe Glu Asp Lys Arg Ile Leu Arg Glu Lys Leu Asn Glu Ile Thr 645 650 655 Trp Leu Ser Asp Gin Gin Lys Asp Val Leu Glu Ser Ser Arg Tyr Gin 660 665 670 Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asn Asp 675 680 685 Gin Gly Glu Arg Ile Ile Asp Glu Leu Trp Asn Thr Asn Lys Asn Phe 690 695 700 Met Gin Ile Gin Ser Asp Asn Asp Phe Ala Lys Arg Ile His Glu Ala 705 710 715 720 Asn Ala Asp Gin Met Lys Ala Val Asp Val Glu Asp Val Leu Ala Asp 725 730 735 Ala Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg Gin Val Val Lys 740 745 750 Val Val Asp Asp Ile Gin Lys Ala Met Gly Gly Val Ala Pro Lys Tyr 755 760 765 Ile Ser Ile Glu Phe Thr Arg Ser Glu Asp Arg Asn Pro Arg Arg Thr 770 775 780 Ile Ser Arg Gin Arg Gin Leu Glu Asn Thr Leu Lys Asp Thr Ala Lys 785 790 795 800 Ser Leu Ala Lys Ser Ile Asn Pro Glu Leu Leu Ser Glu Leu Asp Asn 805 810 815 Ala Ala Lys Ser Lys Lys Gly Leu Thr Asp Arg Leu Tyr Leu Tyr Phe 820 825 830 Thr Gin Leu Gly Lys Asp Ile Tyr Thr Gly Lys Pro Ile Asn Ile Asp 835 840 845 Glu Ile Ser Thr Tyr Asp Ile Asp His Ile Leu Pro Gin Ala Phe Val 850 855 Page 1057 of 3790 860 Leu Arg Gly Ala Met Phe Asn Gin Thr Val Tyr Pro Ala Ser Asp 1085 1090 1095 Page 1059 of 3790 215 1090 PRT Sphingomonas sp. 215 Page 1060 of 3790 Thr Asp Ala Asn His Ile Pro Ser Val Arg Thr Arg Leu Arg Pro Glu 180 185 190 Thr Gly Glu Gly Ala Lys Gly Asp Gly Tyr Asp Phe Tyr Pro Ser Arg 195 200 205 Ala Leu Ile Ala Glu Glu Phe Glu Glu Ile Trp Ala Ala Gin Ala Pro 210 215 220 His Tyr Pro Asp Thr Leu Thr Gin Gin Val His Asp Arg Leu Tyr Glu 225 230 235 240 Ile Ile Phe His Gin Arg Pro Leu Arg Ala Pro Gin Val Gly Gin Cys 245 250 255 Thr Leu Val Ala Gly Glu Thr Arg Leu Pro Lys Ala His Pro Leu Phe 260 265 270 Gin Lys Arg Arg Leu Leu Glu Glu Ile Asn Ala Leu Met Ile Val Arg 275 280 285 Pro Gly Glu Ile Ala Gin Arg Leu Thr Pro Glu Glu Arg Asp Thr Leu 290 295 300 Tyr Leu Lys Leu Lys Asp Lys Arg Thr Val Ser Phe Ala Thr Leu Arg 305 310 315 320 Lys Thr Leu Lys Leu Asp Ser Ala Ala Arg Phe Asn Lys Glu Ser Glu 325 330 335 Asn Arg Thr Glu Leu Lys Gly Asp Glu Val Ala Ala Glu Leu Gly Ala 340 345 350 Lys Thr Arg Leu Gly Thr Arg Trp Gin His Leu Ser Gly Asp Gin Gin 355 360 365 Trp Glu Val Val His Arg Leu Met Ala Leu Glu Ser Gin Ala Asp Glu 370 375 380 Ala Ala Phe Arg Asp Trp Ile Ser Gin Thr Tyr Asp Leu Leu Pro Glu 385 390 395 400 Gin Ala Ala Ala Val Leu Gly Ala Arg Leu Pro Gin Gly His Gly Arg 405 410 415 Phe Gly Pro Thr Ala Thr Thr Thr Leu Ile Asp Ser Leu Leu His Asp 420 425 430 Page 1061 of 3790 Arg Thr Glu Asp Gly Arg Val Val Val Tyr Ser Glu Ala Val Gin Arg 435 440 445 Ser Gly Leu Gly His His Ser Asp Leu Arg His Asp Arg Asp Asp Glu 450 455 460 Asp Val Thr Glu Leu Pro Tyr Tyr Gly Val Ala Leu Glu Arg His Ile 465 470 475 480 Met Pro Gly Thr Ala Glu Pro Thr Asp Pro Glu Glu Met Arg Ile Gly 485 490 495 Arg Leu Thr Asn Pro Thr Val His Ile Gly Leu Asn Gin Leu Arg His 500 505 510 Val Val Asn Arg Leu Ile Arg Ala Tyr Gly Pro Pro Lys Glu Ile Ala 515 520 525 Ile Glu Leu Ala Arg Glu Leu Lys Leu Ser Glu Asp Glu Lys Lys Lys 530 535 540 Arg Asn Ser Glu Asn Arg Asp Asn Arg Leu Ala Ala Glu Gly Arg Ser 545 550 555 560 Lys Lys Leu Glu Glu Ile Arg Gin Arg Asp Thr Gly Ala Asn Arg Ala 565 570 575 Leu Leu Lys Leu Trp Glu Glu Leu Asn Pro Gly Asn Val Leu Asp Arg 580 585 590 Arg Cys Ile Tyr Thr Gly Glu Gin Ile Ser Ile Asp Met Leu Phe Ser 595 600 605 Asp Arg Val Glu Val Asp His Ile Leu Pro Phe Ala Gin Thr Leu Asp 610 615 620 Asp Ser Asn Gly Asn Lys Leu Leu Cys Leu Arg Glu Ala Asn Arg Glu 625 630 635 640 Lys Arg Arg Arg Ser Pro Tyr Glu Ala Trp Gly His Thr Asp Arg Trp 645 650 655 Pro Asp Ile Ala Glu Arg Ala Ser Arg Leu Pro Lys Pro Lys Arg Trp 660 665 670 Arg Phe Glu Pro Asp Ala Met Gin Arg Phe Ala Thr Glu Asp Gly Phe Page 1062 of 3790 675 680 685 Leu Ala Arg His Leu Val Asp Thr Gin Tyr Leu Gly Arg Leu Ala Arg 690 695 700 Glu Tyr Leu Ser Trp Leu Tyr Pro Gly Arg Gly Glu Gly Ser Gly His 705 710 715 720 Val Trp Val Ser Pro Gly Arg Leu Thr Glu Met Val Arg Arg Lys Leu 725 730 735 Gly Leu Asn Asp Leu Leu Pro Asp His Asn Phe Gly Gly Gly Ala Asp 740 745 750 Gin Pro Lys Asn Arg Leu Asp His Arg His His Ala Ile Asp Ala Leu 755 760 765 Val Val Ala Ile Val Asp Arg Gly Met Leu Gin Ala Ile Ala Arg Ala 770 775 780 Ser Gly Gin Asp Gly Ser Glu Gly Arg Glu Arg Ile His Ile Pro Ala 785 790 795 800 Pro Trp Asp Gly Phe Arg Asp Asp Leu Arg Val Ala Val Asn Gly Ile 805 810 815 Ile Val Ser His Arg Pro Asp His Gly Thr Val Ala Lys Ala Gly Leu 820 825 830 Ala Arg Gly Arg Asp Gin Thr Ala Gly Arg Leu His Asn Asp Thr Ala 835 840 845 Tyr Gly Leu Thr Gly Glu Thr Asp Ala Lys Gly Asn Ser Ile Val Val 850 855 860 Arg Arg Ile Pro Leu Ser Ala Ile Lys Lys Pro Ala Asp Ile Ala Arg 865 870 875 880 Val Arg Asp Pro Leu Leu Arg Asn Ala Leu Ala Glu Phe Thr Lys Gly 885 890 895 Leu Asp Gly Lys Ala Phe Glu Ala Arg Ile Gly Arg Phe His Glu Leu 900 905 910 Gly Pro Leu Leu Tyr Arg Gly Ile Arg Arg Val Arg Val Val Glu Thr 915 920 925 Page 1063 of 3790 216 1000 PRT Kingella kingae 216 Met Ala Arg Ala Gin Arg Arg Leu Ile Ser Arg Arg Ala Asn Arg Met 15 10 15 Asn Lys Leu Arg Arg Leu Leu Lys Gin Glu Asn Val Leu Gin Ala Asn 20 25 30 Asp Tyr Asp Glu Lys Gly Leu Ile Ile Gly Leu Pro Asn Gin Ala Trp 35 40 45 Page 1064 of 3790 Glu Leu Arg Ala Gin Gly Leu Asp Arg Lys Leu Glu Pro Lys Glu Trp 50 55 60 Ala Ala Val Leu Ile Asn Leu Val Lys His Arg Gly Tyr Leu Ser Gin 65 70 75 80 Arg Lys Asn Glu Ser Gin Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu 85 90 95 Ser Gly Met Asn His Asn His Gin Leu Leu Gin Ser Gin Ser Asn Gin 100 105 110 Tyr Arg Thr Pro Ala Glu Leu Ala Ile Lys Gin Phe Ala Thr Gin Asp 115 120 125 Gly His Ile Arg Asn Gin Arg Gly Ala Tyr Thr His Thr Phe Asn Arg 130 135 140 Leu Asp Leu Gin Asn Glu Leu Asn Gin Leu Phe Asp Ala Gin Thr Arg 145 150 155 160 Leu Gly Asn Pro His Val Ser Gly Ser Leu Lys Thr Ala Ile Asn Asp 165 170 175 Leu Leu Met Asn Gin Lys Ala Ala Leu Ser Gly Asp Ala Ile Leu Glu 180 185 190 Met Leu Gly Arg Cys Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys 195 200 205 Asn Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu Gly Lys Leu Thr Asn 210 215 220 Leu Arg Ile Gin Asp Asn Gly Leu Glu Ser Ala Leu Ser Arg Glu Gin 225 230 235 240 Arg Glu Leu Leu Leu Asn Glu Pro Tyr Asn Lys Thr Lys Leu Thr Tyr 245 250 255 Gin Gin Val Arg Lys Leu Leu Arg Leu Pro Glu Thr Ala Phe Phe Lys 260 265 270 Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ser Ala Thr Phe Met Glu 275 280 285 Met Lys Ser Tyr His Ala Ile Arg Lys Ser Leu Glu Asn Lys Ser Leu 290 295 300 Page 1065 of 3790 Lys Ser Glu Trp Glu Lys Leu Lys Thr Gin Pro Lys Leu Leu Asp Leu 305 310 315 320 Ile Gly Thr Ala Phe Ser Ile Tyr Lys Thr Asp Asp Glu Ile Ala Gly 325 330 335 Cys Leu Lys Asn Gin Leu Pro Glu Asn Val Ile Ile Ala Leu Gin Glu 340 345 350 Gin Leu Asn Phe Ser Asn Phe Met Glu Leu Ser Leu Lys Ala Leu Glu 355 360 365 Lys Leu Leu Pro Leu Met Glu Gin Gly Leu Arg Tyr Asp Glu Ala Cys 370 375 380 Thr Gin Ile Tyr Gly Asn Arg His Glu Lys Ile Ala Asp Lys Thr Glu 385 390 395 400 Lys Phe Leu Pro Asn Ile Pro Ala Asp Lys Leu Arg Asn Pro Val Val 405 410 415 Leu Arg Thr Leu Thr Gin Ala Arg Lys Val Ile Asn Ala Ile Ile Arg 420 425 430 Arg Tyr Gly Ser Pro Ala Arg Val His Ile Glu Thr Gly Arg Glu Val 435 440 445 Gly Lys Ser Phe Ser Asp Arg Asp Lys Leu Lys Lys Gin Gin Glu Glu 450 455 460 Asn Gin Glu Gin Arg Arg Arg Ala Ile Asp Glu Trp Lys Gin Phe Phe 465 470 475 480 Pro Asn Ala Ala His Glu Pro Lys Ala Val Asp Ile Leu Lys Leu Arg 485 490 495 Leu Tyr Gin Leu Gin Gin Gly Lys Cys Leu Tyr Ser Gly Leu Pro Ile 500 505 510 Asp Val Arg Arg Leu Pro Glu Lys Gly Tyr Val Glu Ile Asp His Ala 515 520 525 Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Ile Leu 530 535 540 Val Leu Ala Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu 545 550 555 560 Page 1066 of 3790 Tyr Leu Arg Gly Ala Asp Asn Ser Glu Ser Trp Arg Leu Phe Val Glu 565 570 575 Asn Val Gin Asn Cys Gin Phe Ser Pro Asn Lys Lys Gin Lys Ile Met 580 585 590 Ala Lys Gin Leu Asp Glu Lys Gly Phe Leu Glu Arg Asn Leu Asn Asp 595 600 605 Thr Arg Tyr Val Ser Arg Phe Leu Cys Gin Phe Ile Ser Glu His Leu 610 615 620 His Leu Thr Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin 625 630 635 640 Ile Thr Ala Leu Leu Arg Gly Arg Trp Gly Leu Ser Lys Asn Arg Glu 645 650 655 Glu Asn Asp Arg His His Ala Val Asp Ala Val Val Val Ala Cys Ser 660 665 670 Thr Val Ala Met Gin Gin Lys Ile Thr Gin Phe Val Arg Tyr Gin Lys 675 680 685 Gly Asn Val Phe Thr Gly Glu Arg Ile Asp Lys Glu Thr Gly Glu Val 690 695 700 Ile Ser Ile His Phe Pro Thr Pro Trp Glu His Phe Arg Glu Glu Val 705 710 715 720 Met Ile Arg Val Phe Asp Asp Asn Pro Leu Arg Thr Leu Pro Glu Lys 725 730 735 Leu Pro Asn Arg Pro Glu Ala Leu His Glu Tyr Val Met Pro Leu Phe 740 745 750 Val Ser Arg Met Pro Thr Arg Lys Met Thr Gly Gin Gly His Lys Glu 755 760 765 Thr Ile Lys Ser Ala Lys Arg Leu Asp Glu Lys Ile Ser Val Leu Arg 770 775 780 Val Pro Leu Thr Gin Leu Lys Leu Asn Asp Leu Glu Asn Met Val Asn 785 790 795 800 Arg Glu Arg Glu Pro Ala Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu 217 1130 PRT Streptococcus pasteurianus 217 Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 15 10 15 Gly Val Gly Ile Ile Glu Ala Lys Thr Gly Lys Val Val His Ala Asn Page 1068 of 3790 25 30 Ser Arg Leu Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg 35 40 45 Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 50 55 60 Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Gly Ile Val Thr Asp Phe 65 70 75 80 Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 85 90 95 Glu Gin Leu Lys Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 100 105 110 Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 115 120 125 Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 130 135 140 Lys Asn Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Leu Glu Lys Tyr 145 150 155 160 Gly Gin Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 165 170 175 His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 180 185 190 Arg Lys Ile Leu Glu Thr Gin Ala Asp Tyr Asn Lys Lys Ile Thr Ala 195 200 205 Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gin Lys Arg Lys Tyr 210 215 220 Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 225 230 235 240 Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 245 250 255 Lys Cys Asn Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 260 265 270 Page 1069 of 3790 Thr Ala Gin Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 275 280 285 Ser Thr Glu Thr Gly Lys Leu Ser Thr Glu Gin Lys Glu Ser Leu Val 290 295 300 Glu Phe Ala Lys Asn Thr Ala Thr Leu Gly Pro Ala Lys Leu Leu Lys 305 310 315 320 Glu Ile Ala Lys Ile Leu Asp Cys Lys Val Asp Glu Ile Lys Gly Tyr 325 330 335 Arg Glu Asp Asp Lys Gly Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 340 345 350 Arg Lys Leu Lys Phe Asn Leu Glu Ser Ile Asn Ile Asp Asp Leu Ser 355 360 365 Arg Glu Val Ile Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Asn Gin Phe 385 390 395 400 Thr Glu Glu Gin Ile Ser Glu Ile Ile Lys Val Arg Lys Ser Gin Ser 405 410 415 Thr Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gin Met Thr Ile 435 440 445 Leu Thr Arg Leu Glu Lys Phe Lys Val Asn Lys Lys Ser Ser Lys Asn 450 455 460 Thr Lys Thr Ile Asp Glu Lys Glu Val Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Val Arg Gin Thr Ile Lys Ile Ile Asn Ala Ala 485 490 495 Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 500 505 510 Asp Lys Asn Ala Asp Asp Glu Lys Lys Phe Ile Asp Lys Arg Asn Lys 515 520 525 Page 1070 of 3790 Glu Asn Lys Lys Glu Lys Asp Asp Ala Leu Lys Arg Ala Ala Tyr Leu 530 535 540 Tyr Asn Ser Ser Asp Lys Leu Pro Asp Glu Val Phe His Gly Asn Lys 545 550 555 560 Gin Leu Glu Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Ser Gly Lys Pro Ile Ser Ile Gin Glu Leu Val His Asn Ser 580 585 590 Asn Asn Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Trp Thr Asn Gin Glu 610 615 620 Lys Gly Gin Lys Thr Pro Tyr Gin Val Ile Asp Ser Met Asp Ala Ala 625 630 635 640 Trp Ser Phe Arg Glu Met Lys Asp Tyr Val Leu Lys Gin Lys Gly Leu 645 650 655 Gly Lys Lys Lys Arg Asp Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 660 665 670 Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gin Ser Ala Leu Arg Glu 690 695 700 Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg Lys Trp Lys Ile Asp Lys Ser Arg Glu Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Lys 740 745 750 Leu Trp Glu Lys Gin Asp Asn Pro Met Phe Val Asp Tyr Gly Lys Asn 755 760 765 Gin Val Val Asp Lys Gin Thr Gly Glu Ile Leu Ser Val Ser Asp Asp 770 775 780 Page 1071 of 3790 Asp Ala Ile Lys Glu Lys Glu Gly Ile Gly Lys Lys Ser Glu Phe 1010 1015 1020 Lys Phe Thr Leu Tyr Arg Asn Asp Leu Ile Leu Ile Lys Asp Ile Page 1072 of 3790 1025 1030 1035 Gin Ala Lys Tyr Ser Val Tyr Glu Leu Arg Val Ala Gly Leu Asp Arg Page 1074 of 3790 Arg Phe Asn Leu Val Asn Tyr Gly Ser Leu Gin Thr Gin Lys Glu Ile 355 360 365 Glu Thr Val Glu Lys Lys Thr Arg Phe Val Asp Phe Lys Ala Tyr His 370 375 380 Asp Leu Val Lys Val Leu Pro Glu Glu Met Trp Gin Ser Arg Gin Leu 385 390 395 400 Leu Asp His Ile Gly Thr Ala Leu Thr Leu Tyr Ser Ser Asp Lys Arg 405 410 415 Arg Arg Arg Tyr Phe Ala Glu Glu Leu Asn Leu Pro Ala Glu Leu Ile 420 425 430 Glu Lys Leu Leu Pro Leu Asn Phe Ser Lys Phe Gly His Leu Ser Ile 435 440 445 Lys Ser Met Gin Asn Ile Ile Pro Tyr Leu Glu Met Gly Gin Val Tyr 450 455 460 Ser Glu Ala Thr Thr Asn Thr Gly Tyr Asp Phe Arg Lys Lys Gin Ile 465 470 475 480 Ser Lys Asp Thr Ile Arg Glu Glu Ile Thr Asn Pro Val Val Arg Arg 485 490 495 Ala Val Thr Lys Thr Ile Lys Ile Val Glu Gin Ile Ile Arg Arg Tyr 500 505 510 Gly Lys Pro Asp Gly Ile Asn Ile Glu Leu Ala Arg Glu Leu Gly Arg 515 520 525 Asn Phe Lys Glu Arg Gly Asp Ile Gin Lys Arg Gin Asp Lys Asn Arg 530 535 540 Gin Thr Asn Asp Lys Ile Ala Ala Glu Leu Thr Glu Leu Gly Ile Pro 545 550 555 560 Val Asn Gly Gin Asn Ile Ile Arg Tyr Lys Leu His Lys Glu Gin Asn 565 570 575 Gly Val Asp Pro Tyr Thr Gly Asp Gin Ile Pro Phe Glu Arg Ala Phe 580 585 590 Ser Glu Gly Tyr Glu Val Asp His Ile Ile Pro Tyr Ser Ile Ser Trp 595 600 605 Page 1075 of 3790 Asp Asp Ser Tyr Thr Asn Lys Val Leu Thr Ser Ala Lys Cys Asn Arg 610 615 620 Glu Lys Gly Asn Arg Ile Pro Met Val Tyr Leu Ala Asn Asn Glu Gin 625 630 635 640 Arg Leu Asn Ala Leu Thr Asn Ile Ala Asp Asn Ile Ile Arg Asn Ser 645 650 655 Arg Lys Arg Gin Lys Leu Leu Lys Gin Lys Leu Ser Asp Glu Glu Leu 660 665 670 Lys Asp Trp Lys Gin Arg Asn Ile Asn Asp Thr Arg Phe Ile Thr Arg 675 680 685 Val Leu Tyr Asn Tyr Phe Arg Gin Ala Ile Glu Phe Asn Pro Glu Leu 690 695 700 Glu Lys Lys Gin Arg Val Leu Pro Leu Asn Gly Glu Val Thr Ser Lys 705 710 715 720 Ile Arg Ser Arg Trp Gly Phe Leu Lys Val Arg Glu Asp Gly Asp Leu 725 730 735 His His Ala Ile Asp Ala Thr Val Ile Ala Ala Ile Thr Pro Lys Phe 740 745 750 Ile Gin Gin Val Thr Lys Tyr Ser Gin His Gin Glu Val Lys Asn Asn 755 760 765 Gin Ala Leu Trp His Asp Ala Glu Ile Lys Asp Ala Glu Tyr Ala Ala 770 775 780 Glu Ala Gin Arg Met Asp Ala Asp Leu Phe Asn Lys Ile Phe Asn Gly 785 790 795 800 Phe Pro Leu Pro Trp Pro Glu Phe Leu Asp Glu Leu Leu Ala Arg Ile 805 810 815 Ser Asp Asn Pro Val Glu Met Met Lys Ser Arg Ser Trp Asn Thr Tyr 820 825 830 Thr Pro Ile Glu Ile Ala Lys Leu Lys Pro Val Phe Val Val Arg Leu 835 840 845 Ala Asn His Lys Ile Ser Gly Pro Ala His Leu Asp Thr Ile Arg Ser 850 855 860 Page 1076 of 3790 Tyr Phe Gly Arg Tyr His Lys Val His Glu Lys Lys Arg Gin Leu Page 1077 of 3790 1100 1105 1110 Phe Val Lys Arg Asp Glu 1115 219 1126 PRT Lactobacillus farciminis 219 Thr Ser Ala Tyr Glu Lys Glu Ala Lys Gin Ile Ile Ala Thr Gin Gin Page 1078 of 3790 195 200 205 Gin Phe Tyr Pro Glu Ser Leu Thr Asp Lys Phe Thr Glu Glu Tyr Cys 210 215 220 Gin Ile Leu Thr Arg Lys Arg Asp Tyr Phe Val Gly Pro Gly Asn Glu 225 230 235 240 Lys Ser Arg Thr Asp Tyr Gly Ile Tyr Lys Thr Asp Gly Arg Thr Leu 245 250 255 Asp Asn Leu Phe Glu Glu Leu Ile Gly His Asp Lys Ile Tyr Pro Glu 260 265 270 Glu Leu Arg Ala Ser Ala Ala Ser Tyr Thr Ala Gin Leu Phe Asn Val 275 280 285 Leu Asn Asp Leu Asn Asn Leu Arg Ile Leu Asn Tyr Glu Asp Gly Lys 290 295 300 Leu Thr Lys Glu Asp Lys Glu Lys Ile Ile Ala Glu Ile Lys Asn Asn 305 310 315 320 Thr Thr Thr Ile Asn Met Leu Asn Val Ile Lys Lys Val Ala Gly Cys 325 330 335 Ser Lys Asp Asp Ile Lys Gly Phe Arg Val Asn Glu Lys Asp Lys Pro 340 345 350 Glu Ile Ser Ser Met Pro Val Tyr Arg Lys Ile His Lys Asp Leu Leu 355 360 365 Lys Ala Gly Val Asp Ile Ser Asp Trp Pro Val Glu Phe Ile Asp Glu 370 375 380 Leu Ser Phe Ile Leu Thr Leu Asn Thr Glu Asn Gly Glu Ile Arg Lys 385 390 395 400 Gin Leu Asn Asn Arg Leu Ala Pro Lys Phe Asp Phe Leu Asn Ala Asp 405 410 415 Leu Ile Gin Leu Ile Ile Asp Asn Lys Asp Ser Phe Glu Ile Lys Thr 420 425 430 Asn Asn Lys Trp His Arg Phe Ser Val Lys Thr Met Asn Lys Leu Ile 435 440 445 Page 1079 of 3790 Pro Glu Met Met Glu Arg Pro Val Glu Gin Met Thr Leu Leu Asn Glu 450 455 460 Met Gly Leu Val Lys Lys Asp Lys Lys Arg Phe Glu Asn Asn Lys Tyr 465 470 475 480 Leu Pro Tyr Lys Glu Ile Ala Lys Asp Ile Phe Asn Pro Val Ala Ser 485 490 495 Lys Ser Val Arg Glu Ala Leu Lys Ile Val Asn Ala Val Leu Lys Lys 500 505 510 Tyr Gly His Ile Asp Tyr Leu Val Val Glu Met Pro Arg Asp Lys Asn 515 520 525 Leu Lys Glu Glu Gin Asp Asn Ile Lys Glu Phe Gin Asn Lys Asn Lys 530 535 540 Lys Ala Lys Asp Ala Ala Phe Glu Ala Phe Val Lys Ser Val Gly Ser 545 550 555 560 Glu Gin Arg Val Lys Glu Ala Leu Ser Lys Asn Arg Lys Leu Gin Met 565 570 575 Lys Met Arg Leu Trp Tyr Gin Gin Gin Glu Ile Asp Pro Tyr Asn Gly 580 585 590 Lys Thr Ile Asp Ala Thr Asp Leu Ile Asn Asn Pro Asp Lys Phe Glu 595 600 605 Ile Asp His Ile Ile Pro Gin Ser Ile Ser Phe Tyr Asp Ser Ile Asn 610 615 620 Asn Lys Thr Leu Cys Phe Ala Ser Met Asn Gin Val Lys Gly Gin Lys 625 630 635 640 Thr Pro Tyr Glu Phe Met Leu Glu Gly His Gly Gin Ser Tyr Asp Lys 645 650 655 Phe Lys Ala Thr Val Met Ala Asn Lys Asn Phe Gly Lys Ala Lys Arg 660 665 670 Ala Asn Tyr Leu Phe Glu Glu Asn Val Ser Asp Ile Glu Thr Arg Lys 675 680 685 Arg Phe Leu Ser Arg Asn Leu Val Asp Thr Arg Tyr Ser Ser Arg Val 690 695 700 Page 1080 of 3790 Val Leu Asn Ser Leu Gin Asp Phe Phe Arg Glu Lys Ser Ala Asp Thr 705 710 715 720 Lys Val Thr Val Ile Arg Gly Lys Phe Thr Ser Asn Met Arg Lys His 725 730 735 Trp His Ile Asp Lys Thr Arg Glu Thr Phe His His His Ala Ile Asp 740 745 750 Ala Ser Ile Ile Ala Ala Thr Pro Phe Leu Arg Met Trp Lys Lys Gly 755 760 765 Gly Thr Ile Phe Pro Val Lys Val Gly Glu Glu Ser Ile Asp Ile Glu 770 775 780 Thr Gly Glu Ile Leu Asp Asp Lys Asn Phe Asp Lys Ala Met Tyr Glu 785 790 795 800 Glu Pro Tyr Ser Gly Phe Val Ser Glu Ile Met Asn Ala Asp Asp Arg 805 810 815 Ile Lys Phe Ser His Gin Val Asp Lys Lys Met Asn Arg Lys Val Ser 820 825 830 Asp Ala Thr Ile Tyr Ser Thr Arg Thr Gly Lys Leu Ala Lys Asp Lys 835 840 845 Lys Asp Ala Glu Tyr Ile Val Ala Lys Val Lys Asp Ile Tyr Ser Val 850 855 860 Asp Gly Phe Lys Lys Phe Lys Lys Val Tyr Asp Lys Asp Lys Thr Lys 865 870 875 880 Phe Leu Leu Tyr Lys Tyr Asp Pro Arg Thr Phe Ser Lys Leu Glu Arg 885 890 895 Ile Ile Ser Asp Cys Pro Asp Lys Val Glu Lys Val Gin Thr Asn Gly 900 905 910 Lys Val Lys Ala Val Asp Ile Ser Pro Phe Glu Met Tyr Arg Arg Asp 915 920 925 His Gly Met Ile Lys Lys Tyr Ser Lys Lys Gly Asn Gly Pro Ala Ile 930 935 940 Lys Gin Leu Lys Tyr Leu Asp Lys Lys Leu Gly Ser His Ile Asp Ile 945 950 955 960 Page 1081 of 3790 220 1380 PRT Eggerthella sp. 220 Met Asn Leu Arg His Val Gly Asn Tyr Asn Ile Gly Leu Asp Met Gly 15 10 15 Thr Ala Ser Val 20 Gly Trp Ala Ala Ile Asp Glu Gin 25 Gly Glu Leu 30 Leu His Phe Lys Gly Lys Pro Thr Trp Gly Ser Arg Leu Phe Asp Ser Ala 35 40 45 Page 1082 of 3790 Asn Thr Ala Ala Thr Ala Arg Met Pro Arg Gly Gin Arg Arg Arg Tyr 50 55 60 Ile Arg Arg Arg Trp Arg Leu Asp Leu Leu Gin Lys Phe Phe Ser Glu 65 70 75 80 Glu Met Ala Glu Lys Asp Pro Glu Phe Phe Ile Arg Leu Arg Gin Ser 85 90 95 Ser Leu Trp Pro Glu Asp Arg Glu Gly Gly His Thr Ala Tyr His Trp 100 105 110 Pro Leu Phe Asn Asp Ser Asp Phe Asn Glu Lys Glu Tyr Tyr Glu Lys 115 120 125 Phe Pro Thr Ile Phe His Leu Arg Gin Trp Leu Met Glu Thr Asp Glu 130 135 140 Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Phe His Asn Ile Val Lys 145 150 155 160 His Arg Gly Asn Phe Leu Gin Glu Asn Asn Asp Ser Leu Ser Ala Gin 165 170 175 Asn Ala Asn Met Arg Glu Ser Leu Glu Ser Phe Cys Ile Ala Leu Glu 180 185 190 Glu Trp Cys Asp Glu Lys Glu Leu Thr Cys Ser Cys Asp Pro Gin Lys 195 200 205 Leu Glu His Leu Phe Lys Glu Val Lys Tyr Arg Ser Asp Ile Arg Asp 210 215 220 Gly Phe Ala Ala Leu Leu Gly Leu Ala Cys Ser Gly Glu Asn Glu Val 225 230 235 240 Asp Val Lys Ala Met Ala Lys Glu Met Gly Lys Ala Ile Val Gly Tyr 245 250 255 Lys Ala Asp Phe Ser Lys Ile Phe Thr Glu Cys Asp Lys Glu Gly Ser 260 265 270 Ser Phe Arg Leu Ser Asp Asp Glu Gly Pro Glu Ala Phe Leu Asp Ile 275 280 285 Cys Pro Asp Asp Gly Ile Ala Leu Phe Glu Ala Ile Gin Met Val Tyr Page 1084 of 3790 Leu Pro Arg Cys Ser Leu Leu Tyr Glu Glu Tyr Cys Val Leu Asn Glu 545 550 555 560 Leu Asn Gly Ala Arg Trp Thr Gin Asp Gly Asp Lys Phe Ile Arg Phe 565 570 575 Asp Tyr Lys Asp Arg Ser Asp Ile Ile Glu Glu Leu Phe Lys Lys Arg 580 585 590 Arg Gly Arg Ile Gin Tyr Ala Ala Val Ala Asp Trp Met Lys Gin Glu 595 600 605 Arg Ser His Ala Asn Val His Val Ser Gly Gly Gin Gly Glu Asn Ala 610 615 620 Phe Glu Ser Arg Leu Ser Ser Tyr His Phe Phe Cys Asn Asp Val Phe 625 630 635 640 Gly Val Asp Glu Leu Pro Gly Ser Tyr Val Asp Met Val Glu Glu Ile 645 650 655 Ile Leu Trp Ser Thr Leu Phe Glu Asp Arg Ser Ile Leu Arg Glu Glu 660 665 670 Ile Gin Arg Lys Tyr Gly Asp Val Leu Asn Glu Glu Gin Ile Lys Thr 675 680 685 Ile Cys Lys Lys Arg Phe Ser Gly Trp Gly Arg Leu Ser Arg Lys Leu 690 695 700 Leu Cys Ser Leu Lys Ala Gin Thr Asp Asn Gly Pro Lys Ser Ile Met 705 710 715 720 Asp Ile Leu Gin Glu Gly Asp Gin Asn Asn Gly Arg Val Gly Arg Ala 725 730 735 Met Val Phe Gin Glu Ile Leu His Asp Glu Gin Leu Gly Phe Glu Gin 740 745 750 Lys Ile Glu Glu Glu Asn Thr Gin Ser Met Leu Glu Gly Glu Asn Leu 755 760 765 Leu Ile Glu Asp Leu Pro Gly Ser Pro Ala Ile Arg Arg Ser Ile Asn 770 775 780 Gin Ala Val Arg Ile Val Asp Glu Ile Val Gly Ile Ala Gly His Ala 785 790 795 800 Page 1085 of 3790 Page 1086 of 3790 Phe Asp Val Leu Ile Glu Lys Tyr Ala Arg Tyr Ala Pro Arg Leu Page 1087 of 3790 1280 1285 1290 1370 1375 1380 221 1430 PRT Capnocytophaga canimorsus 221 Met Lys His Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Val Val Lys Glu Ala Gin Asn Asp Asn Glu Gin Ser Glu Ile Val 20 25 30 Asp Val Gly Val Arg Val Asn Pro Leu Thr Thr Asp Glu Lys Thr Asn 35 40 45 Phe Glu Lys Gly Lys Pro Ile Ser Thr Asn Ala Asp Arg Thr Leu Lys 50 55 60 Arg Ser Ala Arg Arg Asn Leu Gin Arg Tyr Lys Leu Arg Arg Lys Glu 65 70 75 80 Leu Ile Glu Leu Leu Lys Glu His Gin Leu Ile Ser Thr Asp Thr Ile 85 90 95 Leu Thr Glu Asn Gly Lys Gly Thr Thr Phe Gin Thr Leu Glu Leu Arg 100 105 110 Ala Lys Ser Ala Lys Glu Lys Ile Ser Leu Glu Glu Leu Ala Arg Val Page 1088 of 3790 115 120 125 Phe Leu Thr Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 130 135 140 Lys Asn Glu Asp Glu Gly Gin Leu Ile Asp Gly Met Glu Ile Ala Lys 145 150 155 160 Arg Leu Tyr Glu Glu Asn Leu Thr Thr Gly Gin Leu Ser Leu Gin Leu 165 170 175 Leu Lys Glu Gly Lys Lys Ser Leu Pro Asp Tyr Tyr Arg Ser Asp Leu 180 185 190 Gin Phe Glu Leu Asp Lys Val Trp Asn Phe Gin Lys Gin Phe His Ser 195 200 205 His Ile Leu Thr Asp Glu Phe Tyr Ala Gin Leu Lys Gly Lys Gly Gin 210 215 220 Arg Ala Thr Ser Ala Leu Phe Leu Ala Lys Tyr Gin Ile Tyr Thr Ala 225 230 235 240 Glu Asn Lys Gly Ser Arg Glu Asp Lys Lys Leu Gin Ala Tyr Gin Trp 245 250 255 Arg Val Asp Ala Leu Ser Lys Glu Leu Thr Arg Glu Gin Leu Ala Phe 260 265 270 Val Ile Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Glu Thr 290 295 300 Val Gly Glu Tyr Leu Trp Lys Gin Ile Ala Ala Asn Pro His Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Gin Ile Trp Lys Thr Gin Ser Ala Phe Tyr Pro Glu Ile Leu Thr Asp 340 345 350 Glu Leu Lys Lys Glu Leu Arg Asp Val Val Ile Phe Tyr Gin Arg Lys 355 360 365 Page 1089 of 3790 Leu Lys Ser Gin Lys Ser Leu Val Ser Phe Cys Glu Phe Glu Asn Lys 370 375 380 Glu Ile Glu Ile Lys Lys Glu Asp Gly Thr Ser Thr Lys Lys Val Ile 385 390 395 400 Gly Leu Lys Val Ala Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys 405 410 415 Ile Trp Gin Asn Leu Asn Asn Val Leu Ile Arg Lys Lys Gly Ser Lys 420 425 430 Thr Lys Lys Val Asp Lys Asn Gin Gin Ala Val Leu Phe Glu Glu Glu 435 440 445 Lys Thr Ile Phe Glu Leu Asp Leu Glu Ala Lys Gin Ala Leu Phe Asn 450 455 460 Glu Leu Asn Leu Lys Gly Asn Leu Lys Ala Tyr Tyr Cys Leu Glu Ile 465 470 475 480 Leu Gly Tyr Ser Pro Lys Glu Trp Glu Met Asn Tyr Ser Val Leu Glu 485 490 495 Gly Asn Arg Thr Asn Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Thr 500 505 510 Asp Leu Glu Gly Tyr Asp Ala Lys Asn His Leu Lys Val Lys Leu Asn 515 520 525 Lys Asp Glu Val Glu Leu Asp Asp Leu Lys Val Pro Ala Ser Glu Ile 530 535 540 Lys Asp Met Val Gin Ala Ile Phe Lys Glu Ala Gly Ile Asn Thr Asp 545 550 555 560 Ile Leu His Phe Asn Ala Glu Leu Asp Gly Lys Asp Phe Glu Asn Gin 565 570 575 Ala Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asp 580 585 590 Ser Lys Ser Gly Asn Glu Leu Leu Tyr Lys Leu Leu Glu Thr Lys Phe 595 600 605 Gly Phe Lys Lys Glu Tyr Ala Gin Ile Leu Ala Asn Val Ser Leu Ser 610 615 620 Page 1090 of 3790 Asp Asp Tyr Gly Ser Leu Ser Thr Lys Ala Met Arg Lys Ile His Pro 625 630 635 640 Tyr Ile Lys Glu Asn Lys Phe Ser Thr Ala Cys Glu Leu Ala Gly Tyr 645 650 655 Arg His Ser Lys His Ser Leu Thr Lys Glu Glu Asn Asp Asn Arg Val 660 665 670 Leu Lys Asp Ser Leu Glu Val Leu Lys Lys Asn Ser Leu Arg Gin Pro 675 680 685 Val Val Glu Lys Ile Leu Asn Gin Met Ile Asn Leu Val Asn Ala Leu 690 695 700 Leu Lys Lys Tyr Arg Thr Glu Asn Pro Asn Phe Lys Phe Asp Glu Ile 705 710 715 720 Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Ala 725 730 735 Asn Met Thr Val Asn Ile Asn Lys Ala Lys Thr Glu His Glu Lys Ile 740 745 750 Ile Lys Ile Leu Lys Asn Glu Phe Gly Leu Pro Asn Pro Thr Arg Asn 755 760 765 Asp Ile Ile Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Ala Asn Gly Tyr 770 775 780 Lys Asp Leu Tyr Thr Asn Glu Tyr Ile Glu Lys Gin Asp Leu Phe Thr 785 790 795 800 Lys Asn Ile Asp Ile Glu His Ile Ile Pro Lys Ser Arg Val Phe Asp 805 810 815 Asp Ser Phe Ser Asn Lys Thr Leu Ser Phe Arg Lys Thr Asn Leu Asp 820 825 830 Lys Gly Glu Arg Thr Ala Phe Asp Tyr Ile Glu Ser Lys Phe Gly Ala 835 840 845 Asp Lys Leu Glu Glu Tyr Val Ala Arg Val Glu Asp Leu Tyr Lys Asn 850 855 860 Asn Ile Ile Ser Lys Ala Lys Tyr Gin Lys Leu Leu Lys Lys Glu Ser 865 870 875 880 Page 1091 of 3790 Ala Asn Pro Leu Tyr Gin Ser Leu Leu Lys Lys Arg Leu Glu Glu Glu Tyr 1430 222 1348 PRT Finegoldia magna 222 Page 1094 of 3790 His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 130 135 140 Tyr Tyr Phe Leu Ala Ile Asn Gin Met Met Lys Arg Arg Gly His Phe 145 150 155 160 Leu Ile Asp Gly Gin Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 165 170 175 Gin Gin Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 180 185 190 Glu Glu Phe Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 195 200 205 Lys Lys Thr Glu Lys Lys Asn Ile Leu Lys Glu Leu Ile Asn Ala Gin 210 215 220 Asp Phe Asn Lys Gin Glu Gly Lys Ile Leu Tyr Ser Ile Phe Glu Ser 225 230 235 240 Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 245 250 255 Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 260 265 270 Gly Asp Ser Tyr Glu Glu Asn Leu Gin Tyr Phe Glu Glu Val Leu Gin 275 280 285 Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Ala Tyr Asp Phe Val 290 295 300 Ile Leu Gin Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gin 305 310 315 320 Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 325 330 335 Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gin Val Phe 340 345 350 Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 355 360 365 Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 370 375 380 Page 1095 of 3790 Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gin Cys Asp Cys Glu 385 390 395 400 Asp Glu Asp Val Lys Tyr Leu Leu Gly Lys Ile Glu Gin Glu Asn Phe 405 410 415 Leu Leu Lys Gin Ile Ser Ser Ile Asn Ser Val Ile Pro His Gin Ile 420 425 430 His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Tyr Tyr 435 440 445 Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 450 455 460 Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 465 470 475 480 Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 485 490 495 Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 500 505 510 Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gin Cys Thr Tyr 515 520 525 Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu 530 535 540 Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Gly Lys Pro 545 550 555 560 Ile Asp Thr Asp Val Lys Leu Lys Leu Ile Glu Glu Leu Phe Lys Lys 565 570 575 Lys Thr Lys Val Thr Leu Lys Ser Ile Arg Asp Tyr Met Ile Arg Asn 580 585 590 Asn Phe Ala Asp Lys Glu Asp Phe Asp Asn Ser Glu Lys Asn Leu Glu 595 600 605 Ile Val Ser Asn Met Lys Ser Tyr Ile Asp Phe Asn Asn Ile Leu Gly 610 615 620 Asp Lys Phe Glu Leu Glu Met Val Glu Asp Leu Ile Glu Lys Ile Thr 625 630 635 640 Page 1096 of 3790 Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 645 650 655 Tyr Pro Asp Leu Ser Ser Ser Gin Ile Gin Lys Ile Ile Asn Leu Lys 660 665 670 Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Thr 675 680 685 Gly Thr Asn Ile Glu Thr Gly Glu Ile Asp Thr Val Ile Asn Phe Leu 690 695 700 Arg Asn Ser Ser Asp Asn Leu Met Gin Ile Ile Gly Ser Gin Asn Tyr 705 710 715 720 Ser Phe Asn Asn Asp Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gin 725 730 735 Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 740 745 750 Lys Lys Met Ile Trp Gin Val Ile Arg Ile Thr Glu Glu Ile Thr Lys 755 760 765 Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 770 775 780 Glu Glu Gly Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Ala 785 790 795 800 Leu Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gin Tyr Glu Lys 805 810 815 Leu Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg 820 825 830 Lys Leu Tyr Leu Tyr Tyr Thr Gin Met Gly Arg Asp Met Tyr Thr Gly 835 840 845 Glu Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys 850 855 860 Asp His Ile Ile Pro Gin Ser Met Lys Lys Asp Asp Ser Ile Ile Asn 865 870 875 880 Asn Leu Val Leu Val Asn Lys Asn Ala Asn Gin Thr Thr Lys Gly Asn 885 895 Page 1097 of 3790 890 Gin Asp Val Ser Lys Tyr Gly Gly Tyr Lys Ala Ile Asn Gly Ala 1115 1120 1125 223 1352 PRT Page 1099 of 3790 Megasphaera sp. 223 Met Lys Lys Arg Asn Arg Glu Glu Tyr Tyr Val Gly Leu Asp Ile Gly 15 10 15 Thr Ser Ser Val Gly Trp Ala Val Ala Thr Pro Asp Tyr Arg Ile Pro 20 25 30 Lys Phe Arg Gly His Lys Met Trp Gly Ser Arg Leu Phe Ala Glu Gly 35 40 45 Lys Arg Ala Ala Glu Arg Arg Gin Phe Arg Thr Asn Arg Arg Arg Leu 50 55 60 Ala Arg Arg Arg Asp Arg Leu Gin Ile Leu Glu Glu Leu Phe Ala Glu 65 70 75 80 Glu Met Ala Lys Val Asp Asn Thr Phe Phe Met Arg Leu Lys Glu Ser 85 90 95 Lys Phe Phe Leu Glu Asp Lys Thr Val Lys Glu Lys His Ile Leu Phe 100 105 110 Ser Thr Asp Lys Phe Asp Ala Asp Arg Phe Tyr Lys Asp Asn Pro Thr 115 120 125 Ile Tyr His Val Arg Lys Arg Leu Met Glu Glu Glu Pro Gin Asp Ile 130 135 140 Arg Glu Leu Phe Leu Ala Val His His Ile Leu Lys Tyr Arg Gly His 145 150 155 160 Phe Leu Phe Ala Gly Ser Leu Glu Gin Asn Gly Ala Ser Ile Glu Glu 165 170 175 Leu Val Arg Thr Leu Leu Gly Lys Gin Gly Leu Ala Ile Leu Asp Asp 180 185 190 Thr Ile Asp Ser Asn Glu Met Val Asn Ile Leu Lys Asn Thr Gly Glu 195 200 205 Thr Lys Ser Asp Arg Lys Lys Asp Val Gin Glu Leu Trp Asn Pro Leu 210 215 220 Lys Asp Lys Val Lys Lys Ala Gin Ala Ala Glu Met Ala Gly Leu Val 225 230 235 240 Page 1100 of 3790 Leu Gly Leu Lys Ser Asp Ile Ser Lys Leu Phe Ala Asn Ser Asp Tyr 245 250 255 Lys Asp Leu Asp Ser Ser Ile Lys Asn Ile Asn Phe Ser Ser Gly Asp 260 265 270 Tyr Glu Glu Lys Arg Asp Asp Tyr Ala Asn Ser Ile Gly Asp Asp Ile 275 280 285 Val Leu Leu Asp Thr Met Lys Ala Leu Tyr Asp Thr Leu Ile Leu Ser 290 295 300 Gin Ile Leu Gin Gly Lys Arg Ser Ile Ser Ala Ala Lys Val Glu Asp 305 310 315 320 Tyr Asn Thr His Lys Glu Gin Leu Arg Ala Leu Lys Ala Ile Leu Lys 325 330 335 Pro His Lys Arg Leu Tyr Asn Glu Met Phe Arg Glu Asn Asn Lys Lys 340 345 350 Asp Leu Ser Asn Tyr Val Ala Tyr Ile Ser Ser Tyr Ser Glu Gly Lys 355 360 365 Arg Val Asn Arg Glu Gly Phe Tyr Lys Tyr Val Gin Ala Val Leu Lys 370 375 380 Gin Val Asp Asp Ser Asp Ser Lys Gin Ala Ile Leu Glu Ala Ile Arg 385 390 395 400 Leu Glu Thr Phe Leu Pro Leu Leu Arg Val Lys Asp Asn Ala Val Ile 405 410 415 Pro His Gin Ile His Gin Ala Glu Leu Glu Ala Ile Leu Glu Thr Ala 420 425 430 Arg Lys Lys Tyr Asn Phe Leu Asn Asp Val Ser Asp Gly Val Ser Val 435 440 445 Lys Asp Lys Ile Ile Gin Leu Phe Thr Phe Arg Ile Pro Tyr Tyr Val 450 455 460 Gly Pro Leu Asn Pro His Ser Gly Glu Thr Val Ala Asp Arg Lys Gin 465 470 475 480 Gly Thr Gly Trp Val Val Arg Lys Gin Arg Gly Lys Val Tyr Pro Trp 485 490 495 Page 1101 of 3790 Asn Phe Ala Asp Met Val Asp Val Lys Ala Ser Ala Glu Ala Phe Ile 500 505 510 Thr Asn Leu Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu 515 520 525 Pro Lys Arg Ser Leu Leu Tyr Ser Glu Phe Met Leu Leu Asn Glu Leu 530 535 540 Asn Met Ile Lys Tyr Asp Gly His Glu Leu Pro Val Ala Ile Lys Gin 545 550 555 560 Leu Tyr Ile Glu Gin Val Phe Lys Gin Glu His Lys Lys Gin Thr Lys 565 570 575 Gly Arg Val Leu Asp Phe Leu Lys Arg Asn Gly Leu Ile Thr Gly Ser 580 585 590 Ala Thr Ala Val Ile Thr Gly Met Asp Asp Ala Ile Lys Gly Asp Leu 595 600 605 Gin Ser Tyr Arg Asp Met Val Arg Ile Phe Gly Ala Gly Phe Asp His 610 615 620 Ser Met Ala Glu Arg Ile Ile Arg Trp Val Thr Leu Phe Gly Glu Ala 625 630 635 640 Lys Asp Ile Leu Glu Asn Lys Ile Arg Glu Val Tyr Gly Asn Ser Ile 645 650 655 Ser Asp Ser Gin Met Arg Ala Ile Lys Lys Leu Lys Tyr Ala Asp Trp 660 665 670 Gly Arg Leu Ser Gin Ala Phe Leu Ile Ala Val Lys Gly Cys Asp Lys 675 680 685 Ser Gly Val Glu Arg Asn Ile Ile Thr Cys Leu Arg Ala Ser Ser Gin 690 695 700 Asn Leu Met Glu Ile Leu Ser Asp Gin Gly Thr Tyr Ile Lys Gin Ile 705 710 715 720 Lys Ala Trp Asn His Gin His Thr Thr Asn Met Met Asp Thr Leu Asp 725 730 735 Tyr Gin Leu Val Asp Asp Leu Tyr Val Ala Pro Ser Val Lys Arg Ser Page 1103 of 3790 Ala Tyr Leu Asn Ile Val Val Gly Asn Val Tyr His Glu Lys Phe Thr 995 1000 1005 Page 1104 of 3790 224 650 PRT Haemophilus pittmaniae 224 Met Glu Asn Lys Asn Leu His Tyr Ile Leu Gly Leu Asp Leu Gly Ile 15 10 15 Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Lys Glu Glu Asn Pro 20 25 30 Leu Cys Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Val 35 40 45 Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 50 55 60 Ala Arg Arg Leu Thr Gin Arg Arg Val Ala Arg Leu Lys Lys Ala Lys 65 70 75 80 Arg Leu Leu Lys Leu Glu Asn Ile Leu Leu Ser Thr Asp Glu Arg Leu 85 90 95 Page 1105 of 3790 Pro His Gin Val Trp Gin Leu Arg Val Glu Gly Leu Asp Arg Lys Leu 100 105 110 Lys Arg Gin Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg 115 120 125 Gly Tyr Leu Ser Gin Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 130 135 140 Leu Gly Ala Leu Leu Ser Gly Val Ala Ser Asn His Glu Leu Leu Gin 145 150 155 160 Gin Thr Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu 165 170 175 Val Glu Glu Gly His Ile Arg Asn Gin Gin Gly Ala Tyr Thr His Thr 180 185 190 Phe Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Ser Arg 195 200 205 Gin Gin His Phe Gly Asn Pro Phe Ala Ser Glu Lys Leu Leu Glu Asn 210 215 220 Leu Thr Ala Leu Leu Met Trp Gin Lys Pro Ala Leu Ser Gly Glu Ala 225 230 235 240 Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asp Glu Tyr Lys Ala 245 250 255 Ala Lys Asn Thr Tyr Thr Ala Glu Arg Phe Val Trp Ile Thr Lys Leu 260 265 270 Asn Asn Leu Arg Ile Gin Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp 275 280 285 Asn Glu Arg Leu Ile Leu Ile Glu Gin Pro Tyr Glu Lys Ala Lys Leu 290 295 300 Thr Tyr Ala Gin Val Arg Ser Ile Leu Asn Leu Ser Asp Glu Ala Ile 305 310 315 320 Phe Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Ala Ile Glu Thr 325 330 335 Lys Thr Thr Leu Met Glu Met Lys Ala Tyr His Gin Ile Arg Lys Val 340 345 350 Page 1106 of 3790 Leu Glu Gly Asn Asn Leu Lys Ala Glu Trp Thr Glu Leu Lys Glu Asn 355 360 365 Ser Thr Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr 370 375 380 Asp Glu Asp Ile Ser Thr Tyr Leu Ala Gly Lys Leu Ser Gin Pro Val 385 390 395 400 Leu Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Gin Leu 405 410 415 Ser Leu Lys Ala Leu Tyr Lys Leu Leu Pro Leu Met Gin Gin Gly Leu 420 425 430 Arg Tyr Asp Glu Ala Cys His Glu Met Tyr Gly Asp His Tyr Gly Lys 435 440 445 Lys Thr Tyr Gly Lys Lys Thr Glu Glu Asn His Tyr Phe Leu Pro Gin 450 455 460 Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr 465 470 475 480 Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Leu Tyr Gly Ser Pro 485 490 495 Ala Arg Ile His Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Lys 500 505 510 Asp Arg Arg Glu Leu Glu Lys Arg Gin Glu Glu Asn Arg Lys Gin Arg 515 520 525 Glu Asn Ala Ile Lys Glu Phe Lys Glu Tyr Phe Pro His Phe Ala Gly 530 535 540 Glu Pro Lys Ala Lys Asp Ile Leu Lys Met Arg Leu Tyr Lys Gin Gin 545 550 555 560 Asn Ala Lys Cys Leu Tyr Ser Gly Lys Pro Ile Glu Leu His Arg Leu 565 570 575 Leu Glu Lys Gly Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg 580 585 590 Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Page 1107 of 3790 645 650 225 1062 PRT Ralstonia syzygii Asn Ala Arg Thr Val Gly Glu Ala Leu Ala Arg Arg Leu Glu Asp Gly Page 1109 of 3790 Asp Ala Leu Glu Ser Gly Arg Asp Glu Gin Gly Leu Pro Leu Ser Tyr 420 425 430 Asp Lys Ala Val Val Ala Ala Gly Tyr Pro Ala His Thr Ala Asp Leu 435 440 445 Glu Asn Gly Glu Arg Asp Ala Leu Pro Tyr Tyr Gly Glu Leu Leu Trp 450 455 460 Arg Tyr Thr Gin Asp Ala Pro Thr Ala Lys Asn Asp Ala Glu Arg Lys 465 470 475 480 Phe Gly Lys Ile Ala Asn Pro Thr Val His Ile Gly Leu Asn Gin Leu 485 490 495 Arg Lys Leu Val Asn Ala Leu Ile Gin Arg Tyr Gly Lys Pro Ala Gin 500 505 510 Ile Val Val Glu Leu Ala Arg Asn Leu Lys Ala Gly Leu Glu Glu Lys 515 520 525 Glu Arg Ile Lys Lys Gin Gin Thr Ala Asn Leu Glu Arg Asn Glu Arg 530 535 540 Ile Arg Gin Lys Leu Gin Asp Ala Gly Val Pro Asp Asn Arg Glu Asn 545 550 555 560 Arg Leu Arg Met Arg Leu Phe Glu Glu Leu Gly Gin Gly Asn Gly Leu 565 570 575 Gly Thr Pro Cys Ile Tyr Ser Gly Arg Gin Ile Ser Leu Gin Arg Leu 580 585 590 Phe Ser Asn Asp Val Gin Val Asp His Ile Leu Pro Phe Ser Lys Thr 595 600 605 Leu Asp Asp Ser Phe Ala Asn Lys Val Leu Ala Gin His Asp Ala Asn 610 615 620 Arg Tyr Lys Gly Asn Arg Gly Pro Phe Glu Ala Phe Gly Ala Asn Arg 625 630 635 640 Asp Gly Tyr Ala Trp Asp Asp Ile Arg Ala Arg Ala Ala Val Leu Pro 645 650 655 Arg Asn Lys Arg Asn Arg Phe Ala Glu Thr Ala Met Gin Asp Trp Leu 660 665 670 Page 1110 of 3790 His Asn Glu Thr Asp Phe Leu Ala Arg Gin Leu Thr Asp Thr Ala Tyr 675 680 685 Leu Ser Arg Val Ala Arg Gin Tyr Leu Thr Ala Ile Cys Ser Lys Asp 690 695 700 Asp Val Tyr Val Ser Pro Gly Arg Leu Thr Ala Met Leu Arg Ala Lys 705 710 715 720 Trp Gly Leu Asn Arg Val Leu Asp Gly Val Met Glu Glu Gin Gly Arg 725 730 735 Pro Ala Val Lys Asn Arg Asp Asp His Arg His His Ala Ile Asp Ala 740 745 750 Val Val Ile Gly Ala Thr Asp Arg Ala Met Leu Gin Gin Val Ala Thr 755 760 765 Leu Ala Ala Arg Ala Arg Glu Gin Asp Ala Glu Arg Leu Ile Gly Asp 770 775 780 Met Pro Thr Pro Trp Pro Asn Phe Leu Glu Asp Val Arg Ala Ala Val 785 790 795 800 Ala Arg Cys Val Val Ser His Lys Pro Asp His Gly Pro Glu Gly Gly 805 810 815 Leu His Asn Asp Thr Ala Tyr Gly Ile Val Ala Gly Pro Phe Glu Asp 820 825 830 Gly Arg Tyr Arg Val Arg His Arg Val Ser Leu Phe Asp Leu Lys Pro 835 840 845 Gly Asp Leu Ser Asn Val Arg Cys Asp Ala Pro Leu Gin Ala Glu Leu 850 855 860 Glu Pro Ile Phe Glu Gin Asp Asp Ala Arg Ala Arg Glu Val Ala Leu 865 870 875 880 Thr Ala Leu Ala Glu Arg Tyr Arg Gin Arg Lys Val Trp Leu Glu Glu 885 890 895 Leu Met Ser Val Leu Pro Ile Arg Pro Arg Gly Glu Asp Gly Lys Thr 900 905 910 Leu Pro Asp Ser Ala Pro Tyr Lys Ala Tyr Lys Gly Asp Ser Asn Tyr 915 920 925 Page 1111 of 3790 226 1052 PRT Haemophilus parainfluenzae 226 Met Glu Asn Lys Asn Leu His Tyr Ile Leu Gly Leu Asp Leu Gly Ile 15 10 15 Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 20 25 30 Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Thr 35 40 45 Gin Lys 50 Gly Glu Ser Leu Ala Leu 55 Ser Arg Arg Ser Ala Arg 60 Ser Ala Arg Arg Leu Thr Gin Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 65 70 75 80 Page 1112 of 3790 Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Arg Leu Pro 85 90 95 His Gin Val Trp Gin Leu Arg Val Glu Gly Leu Asp Arg Lys Leu Glu 100 105 110 Arg Gin Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 115 120 125 Tyr Leu Ser Gin Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 130 135 140 Gly Ala Leu Leu Ser Gly Val Ala Ser Asn His Glu Leu Leu Gin Gin 145 150 155 160 Ala Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 165 170 175 Glu Glu Gly His Ile Arg Asn Gin Gin Gly Ala Tyr Thr His Thr Phe 180 185 190 Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Ser Arg Gin 195 200 205 Gin His Phe Gly Asn Pro Phe Ala Ser Glu Lys Leu Leu Glu Asn Leu 210 215 220 Thr Ala Leu Leu Met Trp Gin Lys Pro Ala Leu Ser Gly Glu Asp Ile 225 230 235 240 Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asp Glu Tyr Lys Ala Ala 245 250 255 Lys Asn Thr Tyr Thr Ala Glu Arg Phe Val Trp Ile Thr Lys Leu Asn 260 265 270 Asn Leu Arg Ile Gin Glu Asn Gly Leu Glu Arg Ala Leu Ser Asp Asn 275 280 285 Glu Arg Leu Met Leu Ile Glu Gin Pro Tyr Glu Lys Ala Lys Leu Thr 290 295 300 Tyr Ala Gin Val Arg Ser Ile Leu Asn Leu Ser Asp Asp Ala Ile Phe 305 310 315 320 Lys Gly Val Arg Tyr Ser Gly Glu Asp Lys Lys Ala Ile Glu Thr Lys Ser Gly Lys Pro Leu Glu Leu His Arg Leu Phe Glu Gin Lys Tyr Val 565 570 575 Page 1114 of 3790 Glu Val Asp His Ala Leu Pro Leu Ser Arg Thr Trp Asp Asp Ser Phe 580 585 590 Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gin Asn Lys Gly Asn 595 600 605 Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 610 615 620 Arg Thr Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Ala Lys 625 630 635 640 Lys Gin Arg Ile Leu Ser Gin Lys Leu Asp Glu Lys Gly Phe Ile Glu 645 650 655 Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 660 665 670 Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 675 680 685 Ala Ser Asn Gly Gin Ile Thr Ala Leu Leu Arg Arg Arg Trp Gly Leu 690 695 700 Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 705 710 715 720 Leu Val Ala Cys Ser Thr Val Ala Met Gin Gin Lys Ile Thr Arg Phe 725 730 735 Val Arg Phe Lys Ala Gly Asp Val Phe Thr Gly Glu Arg Ile Asp Arg 740 745 750 Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Thr Pro Trp Gin Phe 755 760 765 Phe Lys Gin Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 770 775 780 Glu Leu Glu Asn Arg Leu Pro Asp Arg Pro Gin Ala Asn His Glu Phe 785 790 795 800 Val Gin Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr Gly 805 810 815 Gin Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asn Glu Gly 820 825 830 Page 1115 of 3790 Leu Asn Arg His Thr Gly Gly Ile Asn Ile Arg Thr His Asp Leu Glu 995 1000 1005 227 1331 PRT Lactobacillus sanfranciscensis 227 Page 1116 of 3790 Met Asn Lys Gin Pro Tyr Asn Ile Gly Leu Asp Ile Gly Thr Ser Ser 15 10 15 Val Gly Trp Ser Ala Thr Glu Leu Asp Asn Arg Leu Leu His Ile Lys 20 25 30 Gly His Asn Gly Ile Gly Val Arg Leu Phe Lys Glu Gly Glu Ser Ala 35 40 45 Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ala Arg Arg 50 55 60 Lys Trp Arg Leu Arg Leu Leu Asn Glu Ile Phe Ala Thr Glu Ile Ala 65 70 75 80 Lys Val Asp Pro Ser Phe Phe Ala Arg Leu Lys Gin Ser Asn Val Ser 85 90 95 Pro Lys Asp Pro Asn Lys Thr Met Phe Glu Asn Ile Leu Phe Asp Asp 100 105 110 Glu Asn Leu Asp Asp Gin Lys Phe His His Asp Tyr Lys Thr Ile Tyr 115 120 125 His Leu Arg Gin Ala Ile Ile Asn His Pro Glu Gin Lys Phe Asp Ile 130 135 140 Arg Leu Ile Tyr Leu Ala Met His His Ile Ile Lys Tyr Arg Gly His 145 150 155 160 Phe Leu Asn Gin Ala Asn Val Gin Asp Phe Lys Gly Gly Lys Ile Asp 165 170 175 Leu Glu Lys Ser Phe Lys Ala Leu Asn Asp Ile Phe Glu Asn Gin Gly 180 185 190 Arg Asp Leu Arg Leu Val Thr Asp Lys Ala Asn Gin Tyr Val Lys Val 195 200 205 Leu Ser Asp Asn Ala Lys Thr Arg Ser Asp Arg Lys Lys Glu Leu Ser 210 215 220 Lys Leu Leu Tyr Val Pro Ile Asp Lys Asp Thr Asp Lys Asn Ser Lys 225 230 235 240 Lys Val Thr Gly Glu Ile Leu Lys Ala Ile Leu Gly Asn Lys Ala Lys 245 250 255 Page 1117 of 3790 Phe Asp Val Ile Phe Gly Ile Glu Val Glu Asn Pro Lys Glu Trp Val 260 265 270 Leu Thr Phe Asn Ser Asp Asp Phe Asp Asp Lys Ile Glu Gly Leu Ser 275 280 285 Ser Gin Met Thr Asp Glu Asp Ser Glu Ile Leu Leu Ile Leu Lys Glu 290 295 300 Leu Tyr Phe Ala Leu Asn Leu Ser Asp Ile Leu Asn Asn Ser Val Thr 305 310 315 320 Asp Lys Asn Ala Lys Thr Leu Ser Glu Ala Met Ile Asn Arg Tyr Asp 325 330 335 Asp His Lys Asn Gin Leu Ala Met Leu Lys Lys Val Ile Asp Ser Ser 340 345 350 Asp Lys Lys His Ala Lys Glu Leu Lys Glu Ala Tyr Ser Ala Tyr Ile 355 360 365 Asp Gly Glu Asn Asn Lys Lys Ile Ser Phe Glu Asp Leu Lys Lys Arg 370 375 380 Ile Gin Lys Asn Leu Val Asp Ser Glu Leu Ser Gin Lys Ile Asn Asp 385 390 395 400 Leu Leu Asp His Asp Tyr Phe Leu Pro Lys Gin Arg Ser Lys Glu Asn 405 410 415 Gly Ala Ile Pro His Gin Leu Gin Gin Gin Glu Leu Asp Gin Ile Ile 420 425 430 Glu Ser Gin Lys Gin Tyr Tyr Pro Phe Leu Ala Glu Leu Asn Pro Asn 435 440 445 Glu Lys Arg Ser Arg Gin Ala Lys Tyr Lys Leu Asp Glu Leu Val Ala 450 455 460 Phe Arg Val Pro Tyr Tyr Val Gly Pro Met Val Glu Val Thr Asp Ser 465 470 475 480 Asn Gin Glu Asn Asn Gly Lys Phe Ala Trp Met Ile Arg Lys Glu Gin 485 490 495 Gly Glu Ile Thr Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Thr Glu 725 730 735 Val Ile Asn Asp Leu Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg 740 745 750 Page 1119 of 3790 Page 1120 of 3790 Page 1121 of 3790 228 1473 PRT Flavobacterium branchiophilum 228 Met Ala Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Val Val Glu Arg Glu Asn Ile Asp Phe Ser Leu Ile Asp Lys Gly 20 25 30 Val Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Lys Gly Ile Glu Ser 35 40 45 Ser Arg Ala Ala Glu Arg Thr Gly Tyr Arg Ser Ala Arg Lys Ile Lys 50 55 60 Tyr Arg Arg Lys 65 Leu Arg Lys 70 Tyr Glu Thr Leu Lys 75 Val Leu Ser Leu 80 Asn Arg Met Cys Pro Leu 85 Ser Ile Glu Glu Val 90 Glu Glu Trp Lys 95 Lys Ser Gly Phe Lys Asp 100 Tyr Pro Leu Asn Pro 105 Glu Phe Leu Lys 110 Trp Leu Ser Thr Asp Glu Glu Ser Asn Val Asn Pro Tyr Phe Phe Arg Asp Arg 115 120 125 Page 1122 of 3790 Ala Ser Lys His Lys Val Ser Leu Phe Glu Leu Gly Arg Ala Phe Tyr 130 135 140 His Ile Ala Gin Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gin Ser 145 150 155 160 Ala Glu Gly Ile Leu Glu Glu His Cys Pro Lys Ile Glu Ala Ile Val 165 170 175 Glu Asp Leu Ile Ser Ile Asp Glu Ile Ser Thr Asn Ile Thr Asp Tyr 180 185 190 Phe Phe Glu Thr Gly Ile Leu Asp Ser Asn Glu Lys Asn Gly Tyr Ala 195 200 205 Lys Asp Leu Asp Glu Gly Asp Lys Lys Leu Val Ser Leu Tyr Lys Ser 210 215 220 Leu Leu Ala Ile Leu Lys Lys Asn Glu Ser Asp Phe Glu Asn Cys Lys 225 230 235 240 Ser Glu Ile Ile Glu Arg Leu Asn Lys Lys Asp Val Leu Gly Lys Val 245 250 255 Lys Gly Lys Ile Lys Asp Ile Ser Gin Ala Met Leu Asp Gly Asn Tyr 260 265 270 Lys Thr Leu Gly Gin Tyr Phe Tyr Ser Leu Tyr Ser Lys Glu Lys Ile 275 280 285 Arg Asn Gin Tyr Thr Ser Arg Glu Glu His Tyr Leu Ser Glu Phe Ile 290 295 300 Thr Ile Cys Lys Val Gin Gly Ile Asp Gin Ile Asn Glu Glu Glu Lys 305 310 315 320 Ile Asn Glu Lys Lys Phe Asp Gly Leu Ala Lys Asp Leu Tyr Lys Ala 325 330 335 Ile Phe Phe Gin Arg Pro Leu Lys Ser Gin Lys Gly Leu Ile Gly Lys 340 345 350 Cys Ser Phe Glu Lys Ser Lys Ser Arg Cys Ala Ile Ser His Pro Asp 355 360 365 Phe Glu Glu Tyr Arg Met Trp Thr Tyr Leu Asn Thr Ile Lys Ile Gly Page 1124 of 3790 Glu Ala Glu Gin Ser Phe Glu Asn Asp Leu Lys Lys Lys Leu Val Leu 625 630 635 640 Phe Tyr Lys Ser Asn Glu Ile Glu Asn Lys Glu Gin Gin Glu Thr Ile 645 650 655 Phe Asn Glu Leu Leu Pro Ile Phe Ile Gin Gin Leu Lys Asp Tyr Glu 660 665 670 Phe Ile Lys Ile Gin Arg Leu Asp Gin Lys Val Leu Ile Phe Leu Lys 675 680 685 Gly Lys Asn Glu Thr Gly Gin Ile Phe Cys Thr Glu Glu Lys Gly Thr 690 695 700 Ala Glu Glu Lys Glu Lys Lys Ile Lys Asn Arg Leu Lys Lys Leu Tyr 705 710 715 720 His Pro Ser Asp Ile Glu Lys Phe Lys Lys Lys Ile Ile Lys Asp Glu 725 730 735 Phe Gly Asn Glu Lys Ile Val Leu Gly Ser Pro Leu Thr Pro Ser Ile 740 745 750 Lys Asn Pro Met Ala Met Arg Ala Leu His Gin Leu Arg Lys Val Leu 755 760 765 Asn Ala Leu Ile Leu Glu Gly Gin Ile Asp Glu Lys Thr Ile Ile His 770 775 780 Ile Glu Met Ala Arg Glu Leu Asn Asp Ala Asn Lys Arg Lys Gly Ile 785 790 795 800 Gin Asp Tyr Gin Asn Asp Asn Lys Lys Phe Arg Glu Asp Ala Ile Lys 805 810 815 Glu Ile Lys Lys Leu Tyr Phe Glu Asp Cys Lys Lys Glu Val Glu Pro 820 825 830 Thr Glu Asp Asp Ile Leu Arg Tyr Gin Leu Trp Met Glu Gin Asn Arg 835 840 845 Ser Glu Ile Tyr Glu Glu Gly Lys Asn Ile Ser Ile Cys Asp Ile Ile 850 855 860 Gly Ser Asn Pro Ala Tyr Asp Ile Glu His Thr Ile Pro Arg Ser Arg 865 870 875 880 Page 1125 of 3790 Asp Asn Val Lys Lys Gin Ala Lys Lys Ile Val Arg Val Arg Gly 1115 1120 1125 Page 1126 of 3790 Lys Arg Asp Val Val Leu Lys Arg Gly Gin Gin Val Val Phe Tyr Page 1127 of 3790 1355 1360 1365 Leu Ser Ile Leu Asp Glu Phe Asn Ile Ser Leu Lys Thr Ser Lys Pro 325 330 335 Ala Glu Glu Arg Lys Lys Ile Ser Ser Asn Gin Lys Lys Ala Gly Glu 340 345 350 Page 1129 of 3790 Glu Ile Ala Glu Val Leu Lys Phe Ala Gly Leu Asn Val Glu Glu Tyr 355 360 365 Thr Ser Lys Leu Asn Ser Lys Thr Lys Leu Lys Leu Lys Leu Leu Lys 370 375 380 Glu Gin Asn Tyr Lys Asp Ile Tyr Asp Gly Gin Glu Ile Asp Val Ile 385 390 395 400 Asp Val Ile Lys Asn Ser Asn Lys Tyr His Glu Glu His Ile Ile Pro 405 410 415 Tyr Ser Leu Cys Phe Ile Asp Ser Arg Arg Asn Lys Val Leu Thr Lys 420 425 430 Phe Glu Asn Asn Lys Gin Lys Gly Asn Lys Thr Pro Phe Gin Trp Leu 435 440 445 Ser Ser Ile Gly Lys Tyr Ala Glu Phe Lys Asp Arg Val Glu Lys Leu 450 455 460 Phe Val Glu Gin Lys Ile Ser Lys Ala Lys Lys Glu Leu Leu Leu Phe 465 470 475 480 Glu Gin Asp Pro Arg Thr Glu Met Leu Gly Phe Ile Glu Lys Asn Leu 485 490 495 Ser Asp Thr Arg Tyr Ala Ser Lys Leu Val Phe Asp Thr Phe Arg Asp 500 505 510 Phe Phe Lys Val Asn Asn Pro Asn Val Lys Ile Lys Val Ile Asn Gly 515 520 525 Ala Leu Thr Asn Tyr Ala Arg Tyr Asn Leu Phe Ala Thr Tyr Lys Asp 530 535 540 Gly Leu Leu Glu Arg Lys Gly Ile Met Lys Gin Arg Glu Phe Tyr Glu 545 550 555 560 His His Gly Ile Asp Ala Thr Ile Leu Ala Phe Leu Gly Ser Asn His 565 570 575 Lys Ile Asn Gin Leu Leu Lys Leu Ser His Lys Phe Lys Lys Gin Asp 580 585 590 Asp Asn Lys Ile Tyr Asp Glu Asn Thr Gly Glu Leu Ile Glu Phe Thr 595 600 605 Page 1130 of 3790 Lys Asp Phe Leu Ser Asp Glu Ala Arg Lys Lys Ala Met Glu Leu Ser 610 615 620 Lys Gin Ile Phe Glu Ile Pro Cys Lys Phe Ser Arg Pro Ile Tyr Arg 625 630 635 640 Lys Ser Asn Val Ser Phe Ser Asn Glu Thr Leu Ile Ser Met Lys Trp 645 650 655 Ile Asp Asp Lys Tyr Thr Lys Gly Val Lys Ile Asn Lys Leu Ser Leu 660 665 670 Val Asn Lys Asp Leu Asp Leu Asn Glu Tyr Phe Ala Asp Tyr Glu Thr 675 680 685 Asn Glu Met Lys Asn Leu Ile Cys Tyr Gin Glu Asp Lys Thr Leu Tyr 690 695 700 Asn Lys Leu Lys Asn Ile Tyr Asp Lys Tyr Asn Asn Phe Val Glu Asn 705 710 715 720 Ser Asn Ile Lys Pro Val Lys Asn Pro Phe Ile Asn Tyr Met Ile Ser 725 730 735 Asn Phe Ser Ser Asp Asp Ser Lys Ile Gin Asn Phe Lys His Ile Ile 740 745 750 Phe Tyr Asp His Lys Gly Asn Lys Lys Phe Val Lys Ser Leu Lys Val 755 760 765 Cys Gly Asp Glu Lys Asn Leu Ser Asn Ile Val Leu Arg Lys Asp Gin 770 775 780 Lys Asp Ile Met Asn Ser Lys Lys Ile Lys Lys Ser Gly Ile Leu Glu 785 790 795 800 Ser Leu Asn Pro Ile Ser Ala Arg Ile Tyr Lys Asp Asn Lys Gly Lys 805 810 815 Tyr Ile Thr Ile Pro Ile Asn Ser Leu Val Leu Asn Trp Thr Lys Lys 820 825 830 Gly Leu Glu Ile Asp Asn Glu Lys Leu Cys Asn Ile Leu Lys Ser Lys 835 840 845 Asn Ile Phe Asn Asn Gin Phe Ile Glu Ile Asn Ala Gly Gin Ser Ile 850 855 860 Page 1131 of 3790 Ile Asn Asn Glu Asn Lys Leu Phe Tyr Phe Val Gly Gly Gly Asp Phe 865 870 875 880 Lys Val Asn Lys Leu Glu Ile Lys Ser Gin Phe Cys Asp Asn Glu Ile 885 890 895 Phe Phe Pro Arg Lys Gin Met Asn Ile Ser Ile Ala Thr Ile Ile Asp 900 905 910 Asn Tyr Lys Leu Cys Glu Val Asp Glu Leu Gly Lys Ile Tyr Asn Ile 915 920 925 Arg Lys Ile Val Leu 930 230 1358 PRT Acidaminococcus intestini 230 Met Gly Lys Met Tyr Tyr Leu Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Tyr Ala Val Thr Asp Pro Ser Tyr His Leu Leu Lys Phe Lys Gly 20 25 30 Glu Pro Met Trp Gly Ala His Val Phe Ala Ala Gly Asn Gin Ser Ala 35 40 45 Glu Arg Arg Ser Phe Arg Thr Ser Arg Arg Arg Leu Asp Arg Arg Gin 50 55 60 Gin Arg Val Lys Leu Val Gin Glu Ile Phe Ala Pro Val Ile Ser Pro 65 70 75 80 Ile Asp Pro Arg Phe Phe Ile Arg Leu His Glu Ser Ala Leu Trp Arg 85 90 95 Asp Asp Val Ala Glu Thr Asp Lys His Ile Phe Phe Asn Asp Pro Thr 100 105 110 Tyr Thr Asp Lys Glu Tyr Tyr Ser Asp Tyr Pro Thr Ile His His Leu 115 120 125 Ile Val Asp Leu Met Glu Ser Ser Glu Lys His Asp Pro Arg Leu Val 130 135 140 Page 1132 of 3790 Tyr Leu Ala Val Ala Trp Leu Val Ala His Arg Gly His Phe Leu Asn 145 150 155 160 Glu Val Asp Lys Asp Asn Ile Gly Asp Val Leu Ser Phe Asp Ala Phe 165 170 175 Tyr Pro Glu Phe Leu Ala Phe Leu Ser Asp Asn Gly Val Ser Pro Trp 180 185 190 Val Cys Glu Ser Lys Ala Leu Gin Ala Thr Leu Leu Ser Arg Asn Ser 195 200 205 Val Asn Asp Lys Tyr Lys Ala Leu Lys Ser Leu Ile Phe Gly Ser Gin 210 215 220 Lys Pro Glu Asp Asn Phe Asp Ala Asn Ile Ser Glu Asp Gly Leu Ile 225 230 235 240 Gin Leu Leu Ala Gly Lys Lys Val Lys Val Asn Lys Leu Phe Pro Gin 245 250 255 Glu Ser Asn Asp Ala Ser Phe Thr Leu Asn Asp Lys Glu Asp Ala Ile 260 265 270 Glu Glu Ile Leu Gly Thr Leu Thr Pro Asp Glu Cys Glu Trp Ile Ala 275 280 285 His Ile Arg Arg Leu Phe Asp Trp Ala Ile Met Lys His Ala Leu Lys 290 295 300 Asp Gly Arg Thr Ile Ser Glu Ser Lys Val Lys Leu Tyr Glu Gin His 305 310 315 320 His His Asp Leu Thr Gin Leu Lys Tyr Phe Val Lys Thr Tyr Leu Ala 325 330 335 Lys Glu Tyr Asp Asp Ile Phe Arg Asn Val Asp Ser Glu Thr Thr Lys 340 345 350 Asn Tyr Val Ala Tyr Ser Tyr His Val Lys Glu Val Lys Gly Thr Leu 355 360 365 Pro Lys Asn Lys Ala Thr Gin Glu Glu Phe Cys Lys Tyr Val Leu Gly 370 375 380 Lys Val Lys Asn Ile Glu Cys Ser Glu Ala Asp Lys Val Asp Phe Asp Page 1134 of 3790 Leu Trp Leu Asn Asn Asn Tyr Gly Thr Leu Thr Ala Asp Asp Val Lys 645 650 655 His Ile Ser Arg Leu Arg Lys His Asp Phe Gly Arg Leu Ser Lys Met 660 665 670 Phe Leu Thr Gly Leu Lys Gly Val His Lys Glu Thr Gly Glu Arg Ala 675 680 685 Ser Ile Leu Asp Phe Met Trp Asn Thr Asn Asp Asn Leu Met Gin Leu 690 695 700 Leu Ser Glu Cys Tyr Thr Phe Ser Asp Glu Ile Thr Lys Leu Gin Glu 705 710 715 720 Ala Tyr Tyr Ala Lys Ala Gin Leu Ser Leu Asn Asp Phe Leu Asp Ser 725 730 735 Met Tyr Ile Ser Asn Ala Val Lys Arg Pro Ile Tyr Arg Thr Leu Ala 740 745 750 Val Val Asn Asp Ile Arg Lys Ala Cys Gly Thr Ala Pro Lys Arg Ile 755 760 765 Phe Ile Glu Met Ala Arg Asp Gly Glu Ser Lys Lys Lys Arg Ser Val 770 775 780 Thr Arg Arg Glu Gin Ile Lys Asn Leu Tyr Arg Ser Ile Arg Lys Asp 785 790 795 800 Phe Gin Gin Glu Val Asp Phe Leu Glu Lys Ile Leu Glu Asn Lys Ser 805 810 815 Asp Gly Gin Leu Gin Ser Asp Ala Leu Tyr Leu Tyr Phe Ala Gin Leu 820 825 830 Gly Arg Asp Met Tyr Thr Gly Asp Pro Ile Lys Leu Glu His Ile Lys 835 840 845 Asp Gin Ser Phe Tyr Asn Ile Asp His Ile Tyr Pro Gin Ser Met Val 850 855 860 Lys Asp Asp Ser Leu Asp Asn Lys Val Leu Val Gin Ser Glu Ile Asn 865 870 875 880 Gly Glu Lys Ser Ser Arg Tyr Pro Leu Asp Ala Ala Ile Arg Asn Lys 885 890 895 Page 1135 of 3790 Page 1136 of 3790 231 1355 Page 1137 of 3790 983 PRT Campylobacter jejuni 231 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser Page 1139 of 3790 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Page 1140 of 3790 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Phe Tyr Gin Ser 785 790 795 800 Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile 805 810 815 Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val 820 825 830 Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile 835 840 845 Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala 850 855 860 Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn 865 870 875 880 Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gin 885 890 895 Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr 900 905 910 Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu 915 920 925 Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys 930 935 940 Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe Glu 945 950 955 960 Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg 965 970 975 Gin Arg Glu Asp Phe Lys Lys 980 Page 1141 of 3790 232 1338 PRT Streptococcus macacae 232 Met Thr Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Gly Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Lys Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ala Lys Ala Asp Glu Ser 85 90 95 Phe Phe Gin Arg Leu Asn Glu Ser Phe Leu Thr Asn Asp Asp Lys Glu 100 105 110 Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Glu Ala His 115 120 125 His His Lys Phe Pro Thr Ile Phe His Leu Arg Lys His Leu Ala Asp 130 135 140 Ser Thr Glu Lys Ser Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gin Leu Lys Ala 165 170 175 Glu Asn Thr Asn Val 180 Gin Thr Leu Phe Asp Asp 185 Phe Val Glu Val 190 Tyr Asp Lys Thr Val Glu Glu 195 Ser His 200 Leu Ser Glu Ile Ser Val 205 Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 210 215 220 Page 1142 of 3790 Lys Tyr Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn Leu Ile 225 230 235 240 Ala Leu Ser Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe Lys Leu 245 250 255 Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu Glu Asp 260 265 270 Leu Gly Glu Leu Leu Gly Lys Ile Gly Asp Asn Tyr Ala Asp Leu Phe 275 280 285 Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly Ile Leu 290 295 300 Thr Ile Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 305 310 315 320 Lys Arg Tyr Glu Glu His Gin Glu Asp Leu Ala Gin Leu Lys Lys Phe 325 330 335 Ile Arg Gin Asn Leu Pro Asp Gin Tyr Ser Glu Val Phe Ser Asp Lys 340 345 350 Thr Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gin Glu 355 360 365 Ala Phe Tyr Lys Tyr Ile Lys Asn Met Leu Ser Lys Thr Glu Gly Ala 370 375 380 Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gin 385 390 395 400 Arg Thr Phe Asp Asn Gly Ser Val Pro His Gin Ile His Leu Gin Glu 405 410 415 Met His Ala Ile Leu Arg Arg Gin Gly Glu Tyr Tyr Pro Phe Leu Lys 420 425 430 Glu Asn Gin Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 435 440 445 Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu 450 455 460 Tyr Lys Ala Asp Lys Lys Val Thr Pro Trp Asn Phe Asp Asp Ile Leu Page 1144 of 3790 Gin Leu Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 725 730 735 Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 740 745 750 Asn Pro Ala Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr Thr 755 760 765 Ala Lys Gly Arg Arg Ser Ser Gin Gin Arg Tyr Lys Arg Leu Glu Glu 770 775 780 Ala Ile Lys Asn Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu 785 790 795 800 His Pro Thr Asp Asn Gin Ala Leu Gin Asn Asp Arg Leu Phe Leu Tyr 805 810 815 Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile 820 825 830 Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Ile Ile Pro Gin Ser Phe 835 840 845 Ile Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Val Ser Ser Ala Lys 850 855 860 Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Asp Val Val Asn Arg 865 870 875 880 Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Cys Gly Leu Ile Ser Gin 885 890 895 Arg Lys Tyr Ser Asn Leu Thr Lys Lys Glu Leu Lys Pro Asp Asp Lys 900 905 910 Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys 915 920 925 His Val Ala Gin Ile Leu Asp Ala Arg Phe Asn Thr Lys Arg Asp Glu 930 935 940 Asn Lys Lys Val Ile Arg Asp Val Lys Ile Ile Thr Leu Lys Ser Asn 945 950 955 960 Leu Val Ser Gin Phe Arg Lys Asp Phe Lys Phe Tyr Lys Val Arg Glu 965 970 975 Page 1145 of 3790 Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Ile 980 985 990 Gly Lys Ala Leu Leu Asp Val Tyr Pro Gin Leu Glu Pro Glu Phe Val 995 1000 1005 Tyr Gly Glu Tyr Pro His Phe His Gly Tyr Lys Glu Asn Lys Ala 1010 1015 1020 Thr Ala Lys Lys Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys 1025 1030 1035 Lys Asp Asp Ile Arg Thr Asp Glu Asn Gly Glu Ile Val Trp Lys 1040 1045 1050 Lys Asp Glu His Ile Ser Asn Ile Lys Arg Val Leu Ser Tyr Pro 1055 1060 1065 Gin Val Asn Ile Val Lys Lys Val Glu Ile Gin Thr Val Gly Gin 1070 1075 1080 Asn Gly Gly Leu Phe Asp Asp Asn Pro Lys Ser Pro Leu Glu Val 1085 1090 1095 Thr Pro Ser Lys Leu Val Pro Leu Lys Lys Glu Leu Asn Pro Lys 1100 1105 1110 Lys Tyr Gly Gly Tyr Gin Lys Pro Thr Thr Ala Tyr Pro Val Leu 1115 1120 1125 Leu Ile Thr Asp Thr Lys Gin Leu Ile Pro Ile Ser Val Met Asn 1130 1135 1140 Lys Lys Gin Phe Glu Gin Asn Pro Val Lys Phe Leu Arg Asp Arg 1145 1150 1155 Gly Tyr Gin Gin Val Gly Lys Asn Asp Phe Ile Lys Leu Pro Lys 1160 1165 1170 Tyr Thr Leu Val Asp Ile Gly Asp Gly Ile Lys Arg Leu Trp Ala 1175 1180 1185 Ser Ser Lys Glu Ile His Lys Gly Asn Gin Leu Val Val Ser Lys 1190 1195 1200 Lys Ser Gin Ile Leu Leu Tyr His Ala His His Leu Asp Ser Asp 1205 1210 1215 Page 1146 of 3790 233 1265 PRT Mycoplasma ovipneumoniae 233 Page 1147 of 3790 Tyr Glu Lys Ile Ile Ser Phe Phe Thr Glu Ile Tyr Lys Lys Cys Ala 100 105 110 Ala Lys His Ser Asn Ile Leu Glu Val Lys Val Lys Ala Leu Asp Ser 115 120 125 Lys Ile Glu Lys Leu Asp Leu Ile Trp Ile Leu His Asp Tyr Leu Glu 130 135 140 Asn Arg Gly Phe Phe Tyr Asp Leu Glu Glu Glu Asn Val Ala Asp Lys 145 150 155 160 Tyr Glu Gly Ile Glu His Pro Ser Ile Leu Leu Tyr Asp Phe Phe Lys 165 170 175 Lys Asn Gly Phe Phe Lys Ser Asn Ser Ser Ile Pro Lys Asp Leu Gly 180 185 190 Gly Tyr Ser Phe Ser Asn Leu Gin Trp Val Asn Glu Ile Lys Lys Leu 195 200 205 Phe Glu Val Gin Glu Ile Asn Pro Glu Phe Ser Glu Lys Phe Leu Asn 210 215 220 Leu Phe Thr Ser Val Arg Asp Tyr Ala Lys Gly Pro Gly Ser Glu His 225 230 235 240 Ser Ala Ser Glu Tyr Gly Ile Phe Gin Lys Asp Glu Lys Gly Lys Val 245 250 255 Phe Lys Lys Tyr Asp Asn Ile Trp Asp Lys Thr Ile Gly Lys Cys Ser 260 265 270 Phe Phe Val Glu Glu Asn Arg Ser Pro Val Asn Tyr Pro Ser Tyr Glu 275 280 285 Ile Phe Asn Leu Leu Asn Gin Leu Ile Asn Leu Ser Thr Asp Leu Lys 290 295 300 Thr Thr Asn Lys Lys Ile Trp Gin Leu Ser Ser Asn Asp Arg Asn Glu 305 310 315 320 Leu Leu Asp Glu Leu Leu Lys Val Lys Glu Lys Ala Lys Ile Ile Ser 325 330 335 Ile Ser Leu Lys Lys Asn Glu Ile Lys Lys Ile Ile Leu Lys Asp Phe 565 570 575 Glu Ile Lys Lys Arg Asn Lys Lys Gly Lys Gly Lys Thr Leu Glu Lys 580 585 590 Page 1149 of 3790 Leu Phe Gin Ile Leu Asn Leu Glu Asn Lys Gly Tyr Lys Leu Ser Asp 595 600 605 Leu Glu Thr Lys Pro Ala Lys Leu Leu Asp Arg Leu Arg Phe Tyr His 610 615 620 Gin Gin Asp Gly Ile Asp Leu Tyr Thr Leu Asp Lys Ile Asn Ile Asp 625 630 635 640 Gin Leu Ile Asn Gly Ser Gin Lys Tyr Glu Ile Glu His Ile Ile Pro 645 650 655 Tyr Ser Met Ser Tyr Asp Asn Ser Gin Ala Asn Lys Ile Leu Thr Glu 660 665 670 Lys Ala Glu Asn Leu Lys Lys Gly Lys Leu Ile Ala Ser Glu Tyr Ile 675 680 685 Lys Arg Asn Gly Asp Glu Phe Tyr Asn Lys Tyr Tyr Glu Lys Ala Lys 690 695 700 Glu Leu Phe Ile Asn Lys Tyr Lys Lys Asn Lys Lys Leu Asp Ser Tyr 705 710 715 720 Val Asp Leu Asp Glu Asp Ser Ala Lys Asn Arg Phe Arg Phe Leu Thr 725 730 735 Leu Gin Asp Tyr Asp Glu Phe Gin Val Glu Phe Leu Ala Arg Asn Leu 740 745 750 Asn Asp Thr Arg Tyr Ser Thr Lys Leu Phe Tyr His Ala Leu Val Glu 755 760 765 His Phe Glu Asn Asn Glu Phe Phe Thr Tyr Ile Asp Glu Asn Ser Ser 770 775 780 Lys His Lys Val Lys Ile Ser Thr Ile Lys Gly His Val Thr Lys Tyr 785 790 795 800 Phe Arg Ala Lys Pro Val Gin Lys Asn Asn Gly Pro Asn Glu Asn Leu 805 810 815 Asn Asn Asn Lys Pro Glu Lys Ile Glu Lys Asn Arg Glu Asn Asn Glu 820 825 830 His His Ala Val Asp Ala Ala Ile Val Ala Ile Ile Gly Asn Lys Asn 835 840 845 Page 1150 of 3790 Ile Leu Ser Lys His Asp Gly Gly Lys Ser Phe Lys Asp Thr Leu 1085 1090 1095 Page 1151 of 3790 Ile Lys 1265 234 1535 PRT Flavobacterium columnare 234 Met Thr Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Ile Arg Asp Thr Glu Asn Glu Gly Ile Asn Gin Ile Leu Asp Lys 20 25 30 Page 1152 of 3790 Gly Ala Arg Ile Phe Ser Glu Gly Val Lys Ser Glu Asn Gly Lys Glu 35 40 45 Ile Ser Arg Ala Ala Glu Arg Thr Ala Tyr Arg Ser Ala Arg Lys Ile 50 55 60 Lys Tyr Arg Arg Lys Leu Arg Lys Tyr Glu Thr Leu Lys Val Leu Ser 65 70 75 80 Ile Asn Gly Met Cys Pro Leu Ser Val Glu Glu Val Glu Gin Trp Lys 85 90 95 Lys Ser Gly Phe Lys Glu Tyr Pro Leu Asn Pro Glu Phe Leu Asp Trp 100 105 110 Leu Arg Thr Asn Glu Asp Lys Asn Ile Asn Pro Tyr Leu Phe Arg Asp 115 120 125 Lys Ala Ser Lys Gin Lys Val Thr Leu Phe Glu Leu Gly Arg Ala Leu 130 135 140 Tyr His Ile Ala Gin Arg Arg Gly Phe Leu Ser Asn Arg Leu Asp Gin 145 150 155 160 Ser Ala Glu Gly Val Phe Glu Glu His Asn Pro Gin Ile Gin Asn Leu 165 170 175 Ile Glu Asp Leu Asp Ser Ser Asn Thr Ile Leu Asn Glu Leu Lys Glu 180 185 190 Tyr Tyr Ile Asn Leu Gly Ile Ile Asp Glu Thr Glu Lys Ser Gly Phe 195 200 205 Lys Lys Asp Leu Asp Glu Gly Glu Lys Lys Leu Lys Ser Leu Tyr Asn 210 215 220 Ser Leu Val Ala Ile Thr Lys Lys Asn Ala Asn Asp Ile Glu Thr Cys 225 230 235 240 Lys Gin Glu Leu Ile Ala Arg Leu Asn Lys Lys Glu Asp Leu Gly Lys 245 250 255 Val Lys Gly Lys Ile Lys Asp Ile Ser Gin Ala Met Leu Asp Arg Asn 260 265 270 Phe Lys Thr Leu Gly Gin Tyr Phe Phe Ser Leu Tyr Asn Lys Glu Arg Page 1153 of 3790 275 280 285 Ile Arg Asn Gin Tyr Thr Ser Arg Glu Glu His Tyr Leu Glu Glu Phe 290 295 300 Ile Ile Ile Cys Gin Thr Gin Gly Ile Glu Gly Ile Asn Thr Asn Glu 305 310 315 320 Lys Leu Pro Glu Lys Lys Phe Thr Gly Leu Ala Lys Asp Leu Tyr Arg 325 330 335 Ala Ile Phe Phe Gin Arg Pro Leu Lys Ser Gin Lys Gly Leu Ile Gly 340 345 350 Lys Cys Ser Phe Glu Lys Asn Lys Ser Arg Cys Ala Val Ser His Pro 355 360 365 Asp Tyr Glu Glu Phe Arg Met Trp Ser Tyr Leu Asn Thr Ile Lys Ile 370 375 380 Gly Thr Gin Ser Glu Lys Thr Leu Arg Phe Leu Thr Leu Glu Glu Lys 385 390 395 400 Leu Lys Leu Val Pro Lys Phe Tyr Arg Lys Ser Asp Phe Asn Phe Glu 405 410 415 Val Leu Ala Lys Glu Leu Val Glu Lys Gly Ala Ser Phe Gly Tyr Tyr 420 425 430 Lys Ser Ser Lys Lys Asn Glu Phe Phe Tyr Trp Phe Asn Tyr Lys Pro 435 440 445 Thr Asp Ser Val Ser Ala Cys Val Val Ser Ala Ser Leu Glu Asn Ala 450 455 460 Ile Gly Lys Asp Trp Lys Ile Lys Thr Phe Glu Tyr Gin Thr Arg Asn 465 470 475 480 Thr Glu Lys Asn Glu Val Thr Lys Ser Val Asp Tyr Lys Asp Leu Trp 485 490 495 His Leu Leu Ser Val Ala Thr Ser Asp Thr Tyr Leu Tyr Asp Phe Ala 500 505 510 Ile Glu Lys Leu Lys Leu Glu Pro Lys Asn Ala Lys Ala Phe Ser Lys 515 520 525 Page 1154 of 3790 Thr Lys Leu Lys Lys Asp Phe Ala Ser Leu Ser Leu Ala Ala Ile Ala 530 535 540 Lys Ile Leu Pro Tyr Leu Lys Gin Gly Leu Leu Tyr Ser His Ala Val 545 550 555 560 Phe Met Ala Asn Ile Glu Asn Ile Val Asp Ala Asp Ile Trp Lys Asp 565 570 575 Glu Glu Gin Gin Lys Phe Ile Gin Ser Lys Ile Val Glu Leu Val Asp 580 585 590 Asn Tyr Ile Val Glu Lys Ser Lys Leu Glu Leu Ile Asn Gly Leu Leu 595 600 605 Lys Ile Tyr Asn Thr Glu Asp Lys Glu Gly Arg Lys Val Tyr Tyr Ser 610 615 620 Lys Glu Ala Glu Ser Leu Phe Glu Ala Asp Leu Arg Lys Lys Leu Val 625 630 635 640 Pro Phe Tyr Lys Ala Asn Ile Ile Ile Glu Glu His Glu Gin Glu Ile 645 650 655 Ile Phe Gin Asp Leu Phe Pro Ile Leu Met Asp Gin Leu Lys Lys Gin 660 665 670 Glu Phe Ile Lys Ile Gly Arg Leu Asp Lys Gin Ile Glu Ala Phe Leu 675 680 685 Glu Gly Glu Asn Glu Glu Gly Gin Ile Phe Cys Asn His Thr Asp Lys 690 695 700 Leu Lys Lys Leu Tyr His Pro Ser Asp Ile Glu Val Phe Lys Lys Lys 705 710 715 720 Thr Ile Lys Asp Glu Trp Gly Asn Glu Lys Val Val Leu Gly Ser Pro 725 730 735 Leu Thr Thr Ser Ile Lys Asn Pro Met Ala Met Arg Ala Leu His Gin 740 745 750 Leu Arg Lys Val Leu Asn Thr Leu Ile Ala Asn Asp Gin Ile Asp Glu 755 760 765 Asp Thr Arg Ile His Ile Glu Met Ala Arg Glu Leu Asn Asp Ala Asn 770 775 780 Page 1155 of 3790 Arg Lys Leu Trp Gly Ile Gin Glu Ser Phe Ile Asp Glu Asn Trp 1010 1015 1020 Trp Lys His Tyr Lys Asp Lys Asp Arg Asp Lys His Thr His His 1025 1030 1035 Page 1156 of 3790 Val Gin Asn Ile Val Asp Asn Val Val Arg Lys Lys Ile Glu Asn Page 1158 of 3790 Asn Lys Pro Thr Arg Lys Met Asn His Asn Gin Phe Thr Ala Phe 1505 1510 1515 Val Glu Gly Ile Asp Phe Lys Val Leu Pro Ser Gly Lys Phe Gin Page 1159 of 3790 Leu Leu Gin Phe Asn Gin Lys Arg Gly Tyr Asn Gin Leu Arg Asp Glu 180 185 190 Glu Glu Glu Ser Val Pro Asn Lys Gin Val Glu Phe Tyr Ser Leu Lys 195 200 205 Ile Ile Asp Val Val Ala Asp Gin Pro Lys Glu Gly Arg Asp Lys Arg 210 215 220 Trp Tyr Ser Ile Asn Leu Glu Asn Gly Trp Thr Tyr Arg Arg Glu Ser 225 230 235 240 Lys Thr Pro Leu Phe Asn Trp Glu Gly Lys Thr Lys Asp Phe Ile Val 245 250 255 Thr Thr Asp Leu Asn Gin Asp Gly Ser Ile Lys Lys Asp Lys Glu Gly 260 265 270 Lys Glu Lys Arg Ser Phe Arg Ala Pro Ser Glu Gly Asp Trp Thr Leu 275 280 285 Leu Lys Lys Lys Thr Glu Lys Glu Ile Tyr Glu Ser Gly Lys Thr Leu 290 295 300 Gly Thr Tyr Ile Tyr Asp Ala Leu Leu Asn Thr Pro Asp Leu Lys Ile 305 310 315 320 Lys Gly Asp Phe Ile Arg Thr Ile Asp Arg Ser Ile Tyr Lys Glu Glu 325 330 335 Leu Gin Gin Ile Ile Asn Lys Gin Lys Glu Tyr His Leu Glu Leu Asn 340 345 350 Ser Ser Lys Leu Tyr Lys Ala Cys Leu Glu Glu Leu Tyr Pro Lys Asn 355 360 365 Glu Ile Tyr Lys Ser Ala Leu Lys Asn Lys Asp Ile Ala Tyr Leu Phe 370 375 380 Ile Asn Asp Ile Leu Tyr Tyr Gin Arg Pro Leu Lys Ala Pro Lys Tyr 385 390 395 400 Asn Ile Gly Lys Cys Thr Tyr Glu Ser Arg Thr Phe Lys Lys Glu Asp 405 410 415 Lys Lys Ile Arg Glu Tyr Ile Pro Ala Val Ala Lys Ser His Pro Leu 420 425 430 Page 1160 of 3790 Phe Gin Glu Phe Arg Leu Trp Gin Trp Ile Lys Asn Leu Lys Ile Tyr 435 440 445 Glu Lys Leu Ser Ser Asp Asn Cys Thr Asp Phe Phe Leu Thr Asn Glu 450 455 460 Gin Asp Phe Glu Asn Leu Phe Glu Phe Leu Trp Asn Lys Lys Glu Ile 465 470 475 480 Asp His Lys Gly Ile Leu Glu Tyr Leu Val Lys Thr Lys Phe Pro Asp 485 490 495 Leu Lys Pro Lys Gin Val Lys Thr Lys Val Lys Glu Tyr Arg Trp Asn 500 505 510 Tyr Val Tyr Asp His Glu Lys Asp Glu Ser Lys Thr Tyr Pro Cys Gly 515 520 525 Glu Thr Tyr Phe Leu Leu Lys Asn Lys Leu Asp Lys Ile Tyr Asn Ala 530 535 540 Gin Asp Asp Phe Leu Asp Lys Glu Arg Leu Tyr Asn Leu Trp His Ile 545 550 555 560 Ile Tyr Ser Val Thr Asp Lys Lys Gin Tyr Glu Lys Ala Leu Ala Lys 565 570 575 Phe Ala Leu Lys Asn His Leu Asp Thr Lys Ser Phe Val Asn Thr Phe 580 585 590 Lys Arg Ile Pro Pro Phe Lys Asn Asp Tyr Ala Ile Tyr Ser Leu Lys 595 600 605 Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Val Gly Lys Tyr Trp Asn 610 615 620 Tyr Asp Asp Ile Asp Pro Ile Thr Lys Gin Lys Ile Gin Cys Ile Ile 625 630 635 640 Thr Gly Glu Glu Asn Asp Thr Ile Ser Thr Leu Val Arg Glu Lys Thr 645 650 655 Asn His Phe Ser Asn Glu Asn Asp Phe Lys Asn Leu Pro Leu Trp Leu 660 665 670 Ala Gly Tyr Ile Val Tyr Asn Ser His Asn Glu Ser Ser Glu Ile Glu 675 680 685 Page 1161 of 3790 Lys Trp Lys Ser Pro Gin Asp Ile Asp Thr Phe Leu Lys Lys Phe Lys 690 695 700 Gin His Ala Leu Arg Asn Pro Ile Val Glu Gin Val Val Thr Glu Thr 705 710 715 720 Leu Arg Val Val Arg Asp Ile Trp Ser Lys Lys Gly Gin Gly Lys Lys 725 730 735 Asp Phe Phe Asn Glu Ile His Ile Glu Leu Gly Lys Asp Leu Lys Asn 740 745 750 Pro Val Asp Lys Arg Arg Lys Leu Ser Ser Thr Asn Thr Lys Asn Glu 755 760 765 Ser Thr Asn Thr Arg Ile Lys Ala Leu Leu Ile Glu Leu Phe Thr Gin 770 775 780 Gly Val Glu Asn Val Lys Pro Asn Ser Pro Lys His Gin Glu Ile Leu 785 790 795 800 Lys Ile Phe Glu Glu Gly Ala Leu Asn Ser Gly Ile Glu Ile Glu Glu 805 810 815 Asp Ile Ile Lys Ile Ser Asn Thr Asp Gin Pro Thr Lys Lys Gin Leu 820 825 830 Glu Leu Tyr Ile Leu Trp Leu Glu His Lys Tyr Lys Ser Pro Tyr Thr 835 840 845 Gly Gin Ser Ile Pro Leu Ser Lys Leu Phe Thr Pro Asn Tyr Glu Ile 850 855 860 Glu His Ile Ile Pro Arg Ser Lys Tyr Tyr Asp Asp Asn Leu Ser Asn 865 870 875 880 Lys Val Ile Cys Glu Thr Glu Ile Asn Arg Leu Lys Asn Asn Gin Leu 885 890 895 Gly Tyr Glu Phe Ile Asn Asn His Glu Ile Arg Glu Val Thr Leu Glu 900 905 910 Glu Gly Lys Thr Ile Arg Leu Leu Ser Pro Glu Gin Tyr Trp Asn Phe 915 920 925 Val Thr Thr Tyr Tyr Ala Lys Asn Lys Ala Lys Arg Glu Asn Leu Leu Page 1163 of 3790 Page 1164 of 3790 Lys 236 1389 PRT Oenococcus kitaharae 236 Page 1165 of 3790 Phe Leu Ile Glu Gly Asp Val Lys Ala Asp Ser Ala Phe Asp Val His 165 170 175 Thr Phe Ala Asp Ala Ile Gin Arg Tyr Ala Glu Ser Asn Asn Ser Asp 180 185 190 Glu Asn Leu Leu Gly Lys Ile Asp Glu Lys Lys Leu Ser Ala Ala Leu 195 200 205 Thr Asp Lys His Gly Ser Lys Ser Gin Arg Ala Glu Thr Ala Glu Thr 210 215 220 Ala Phe Asp Ile Leu Asp Leu Gin Ser Lys Lys Gin Ile Gin Ala Ile 225 230 235 240 Leu Lys Ser Val Val Gly Asn Gin Ala Asn Leu Met Ala Ile Phe Gly 245 250 255 Leu Asp Ser Ser Ala Ile Ser Lys Asp Glu Gin Lys Asn Tyr Lys Phe 260 265 270 Ser Phe Asp Asp Ala Asp Ile Asp Glu Lys Ile Ala Asp Ser Glu Ala 275 280 285 Leu Leu Ser Asp Thr Glu Phe Glu Phe Leu Cys Asp Leu Lys Ala Ala 290 295 300 Phe Asp Gly Leu Thr Leu Lys Met Leu Leu Gly Asp Asp Lys Thr Val 305 310 315 320 Ser Ala Ala Met Val Arg Arg Phe Asn Glu His Gin Lys Asp Trp Glu 325 330 335 Tyr Ile Lys Ser His Ile Arg Asn Ala Lys Asn Ala Gly Asn Gly Leu 340 345 350 Tyr Glu Lys Ser Lys Lys Phe Asp Gly Ile Asn Ala Ala Tyr Leu Ala 355 360 365 Leu Gin Ser Asp Asn Glu Asp Asp Arg Lys Lys Ala Lys Lys Ile Phe 370 375 380 Gin Asp Glu Ile Ser Ser Ala Asp Ile Pro Asp Asp Val Lys Ala Asp 385 390 395 400 Phe Leu Lys Lys Ile Asp Asp Asp Gin Phe Leu Pro Ile Gin Arg Thr 405 410 415 Page 1166 of 3790 Lys Asn Asn Gly Thr Ile Pro His Gin Leu His Arg Asn Glu Leu Glu 420 425 430 Gin Ile Ile Glu Lys Gin Gly Ile Tyr Tyr Pro Phe Leu Lys Asp Thr 435 440 445 Tyr Gin Glu Asn Ser His Glu Leu Asn Lys Ile Thr Ala Leu Ile Asn 450 455 460 Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Val Glu Glu Glu Gin Lys 465 470 475 480 Ile Ala Asp Asp Gly Lys Asn Ile Pro Asp Pro Thr Asn His Trp Met 485 490 495 Val Arg Lys Ser Asn Asp Thr Ile Thr Pro Trp Asn Leu Ser Gin Val 500 505 510 Val Asp Leu Asp Lys Ser Gly Arg Arg Phe Ile Glu Arg Leu Thr Gly 515 520 525 Thr Asp Thr Tyr Leu Ile Gly Glu Pro Thr Leu Pro Lys Asn Ser Leu 530 535 540 Leu Tyr Gin Lys Phe Asp Val Leu Gin Glu Leu Asn Asn Ile Arg Val 545 550 555 560 Ser Gly Arg Arg Leu Asp Ile Arg Ala Lys Gin Asp Ala Phe Glu His 565 570 575 Leu Phe Lys Val Gin Lys Thr Val Ser Ala Thr Asn Leu Lys Asp Phe 580 585 590 Leu Val Gin Ala Gly Tyr Ile Ser Glu Asp Thr Gin Ile Glu Gly Leu 595 600 605 Ala Asp Val Asn Gly Lys Asn Phe Asn Asn Ala Leu Thr Thr Tyr Asn 610 615 620 Tyr Leu Val Ser Val Leu Gly Arg Glu Phe Val Glu Asn Pro Ser Asn 625 630 635 640 Glu Glu Leu Leu Glu Glu Ile Thr Glu Leu Gin Thr Val Phe Glu Asp 645 650 655 Lys Lys Val Leu Arg Arg Gin Leu Asp Gin Leu Asp Gly Leu Ser Asp 885 890 895 Asn Ile Thr Asn Arg Arg Lys Ser Asp Ser Ser Asn Tyr Leu Pro Ala 900 905 910 Page 1168 of 3790 Page 1169 of 3790 Leu Tyr Gin Glu Thr Lys 1385 Page 1170 of 3790 237 1425 PRT Prevotella micans 237 Met Ile Gin Lys Ile Phe Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 15 10 15 Ser Ser Val Arg Asn Leu Glu Leu Gly Glu Asn Leu Thr Glu Gin Leu 20 25 30 Glu Phe Phe Ser Ser Asp Ile Phe Gly Ser Ser Val Ser Lys Asn Ser 35 40 45 Asn Gly Arg Glu Tyr Ser Leu Ala Gly Asn Arg Ser Ala His Arg Arg 50 55 60 Ser Arg Gly Leu Asn Glu Ala Arg Arg Arg Lys Leu Trp Ala Thr Leu 65 70 75 80 Asp Leu Leu Ile Glu His Gly Leu Cys Pro Met Ser Pro Asp Ser Leu 85 90 95 Met Gin Trp Arg Thr Tyr Asp Lys Gin Lys Gly Leu Tyr Arg Gin Tyr 100 105 110 Pro Ile Glu Asp Lys Asp Phe Asn Ala Trp Ile Met Leu Asp Phe Asn 115 120 125 Gly Asp Gly Lys Pro Asp Tyr Ser Ser Pro Tyr Gin Leu Arg Arg Glu 130 135 140 Leu Val Val Arg Gin Phe Asp Phe Asp Gin Pro Ile Glu Arg Tyr Lys 145 150 155 160 Leu Gly Arg Ala Leu Tyr His Ile Ala Gin His Arg Gly Phe Lys Ser 165 170 175 Ser Lys Gly Glu Thr 180 Ile Ala Asp Gin Glu Lys Asn Glu Lys Lys 185 190 Pro Ile Ala Glu Glu 195 Gly Ala Asp Ile Ala Asn Glu Met 200 Lys Ala 205 Ser Glu Thr Lys Leu Ser Lys Gly Leu Val Ala Tyr Met Gin Glu Asn His Leu 210 215 220 Page 1171 of 3790 Lys Thr Val Gly Glu Ala Phe Ala Lys Leu Glu Asp Glu Arg Val Arg 225 230 235 240 Ile Arg Asn Asn Glu Ser Tyr Arg Ala Ile Arg Ser Gin Tyr Gin Asp 245 250 255 Glu Ile Lys Glu Ile Phe Thr Tyr Gin Lys Lys Leu Ser Val Glu Ser 260 265 270 Glu Leu Tyr Glu Arg Leu Thr Ser Glu Lys Lys Gly Val Gly Thr Ile 275 280 285 Phe Tyr Lys Arg Pro Leu Arg Ser Gin Arg Gly Asn Val Gly Lys Cys 290 295 300 Thr Leu Glu Arg Asn Lys Pro Arg Cys Pro Ile Gly Arg Pro Glu Phe 305 310 315 320 Glu Glu Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Ile Arg Glu 325 330 335 Thr Ala Gly Glu Pro Tyr Lys Gin Leu Pro Ile Lys Leu Arg Gin Glu 340 345 350 Leu Leu Lys Asp Cys Phe Leu Ser Lys Val Lys Ala Asp Phe Lys Phe 355 360 365 Glu Asp Ile Arg Lys Tyr Ile Glu Lys Arg Leu Gly Leu Ser Phe Ser 370 375 380 Asn Asp Asp Lys Thr Ile Asn Tyr Lys Asp Ser Val Ser Ile Ala Ala 385 390 395 400 Cys Pro Val Thr Val Arg Met Lys Lys Leu Leu Gly Glu Asn Trp Ala 405 410 415 Asn Cys Arg Ile Asp Gly Glu Lys Arg Arg Gin Ala His Gly Lys Asn 420 425 430 Asn Asn Asn Glu His Ile Val Ser Tyr Thr Glu Glu Asp Ile Trp His 435 440 445 Val Cys Tyr Asn Ala Glu Asp Pro Glu Glu Val Ser Asn Phe Ala Arg 450 455 460 Lys Ala Leu His Trp Asp Glu Asn Lys Ile Lys Glu Leu Val Arg Leu Page 1173 of 3790 Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Thr Lys Trp 725 730 735 Ala Leu Asp Arg Tyr Asn Arg Ile Arg Arg Asp Glu Asn Glu Lys Ile 740 745 750 Arg Lys Ile Leu Lys Glu Leu Asn Pro Thr Thr Asn Ser Ile Ser Glu 755 760 765 Gin Asp Ile Asp Lys Ala Arg Tyr Ile Phe Glu Gin Cys Glu Thr Asp 770 775 780 Phe Tyr Thr Asp Gly Lys Val Pro Tyr Tyr Asn Lys Asp Ile Lys Lys 785 790 795 800 Tyr Lys Leu Trp Leu Glu Gin Gly Gly Gin Cys Leu Tyr Thr Gly Gin 805 810 815 Thr Ile Asn Leu Thr Asn Leu Phe Asn Pro Asn Ala Phe Asp Met Glu 820 825 830 His Thr Ile Pro Lys Ser Ile Ser Phe Asp Asn Ser Asp Gin Asn Leu 835 840 845 Thr Leu Cys Glu Ser Tyr Tyr Asn Arg Phe Ile Lys Lys Asn Asn Ile 850 855 860 Pro Thr Asp Met Pro Asn Tyr Asp Lys Asp Val Thr Ile Asn Gly Lys 865 870 875 880 Glu Tyr Thr Ala Ile Lys Pro Arg Leu Gin Arg Trp Lys Glu Arg Val 885 890 895 Asp Arg Leu Ser Arg Asn Val Asp Phe Trp Lys Gly Gin Ala Arg Arg 900 905 910 Ala Gin Asp Lys Asp Arg Lys Asp Glu Cys Ile Arg Glu Lys His Leu 915 920 925 Trp Asp Met Glu Leu Ala Tyr Trp Lys Gly Lys Leu Glu Arg Phe Thr 930 935 940 Met Thr Asp Val Thr Asp Gly Phe Lys Asn Ser Gin Leu Val Asp Thr 945 950 955 960 Arg Val Ile Thr Arg His Ala Val Leu Tyr Leu Lys Ser Ile Phe Asn 965 970 975 Page 1174 of 3790 His Val Glu Val Gin Arg Gly Glu Thr Thr Ala Glu Phe Arg Lys Ile 980 985 990 Leu Gly Leu Gin Ser Ile Asp Glu Lys Lys Asp Arg Ser Leu His Ser 995 1000 1005 Page 1175 of 3790 238 1473 PRT Mucilaginibacter paludis Page 1176 of 3790 238 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Ile Glu Lys Asp Thr Asp Gin Lys Asn Gly Asn Ile Leu Gly 20 25 30 Thr Gly Ser Arg Ile Ile Pro Met Ser Gin Asp Ile Lys Asp Glu Phe 35 40 45 Gly Lys Gly Asn Ser Ile Ser Gin Thr Ala Asp Arg Thr Lys Phe Arg 50 55 60 Ser Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 His Arg Val Leu Asn Val Leu Gly Phe Leu Pro Lys His Tyr Ala Asp 85 90 95 Gin Ile Asp Phe Lys Lys Arg Leu Gly Lys Leu Val Asn Glu Thr Glu 100 105 110 Pro Lys Leu Val Tyr Asp Asn Lys Asn Phe Ile Phe Lys Lys Ser Phe 115 120 125 Glu Ala Met Leu Ser Asp Phe Asn Gin His Gin Pro Leu Leu Leu Ala 130 135 140 Asp Gly Lys Lys Val Pro Phe Asp Trp Thr Ile Tyr Tyr Leu Arg Lys 145 150 155 160 Lys Ala Leu Thr Glu Lys Ile Glu Lys Glu Glu Leu Ala Trp Leu Ile 165 170 175 Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr Gin Leu Arg Gly Glu Glu 180 185 190 Glu Glu Glu Asn Pro Asn Lys Met Val Ala Phe His Ser Leu Lys Ile 195 200 205 Val Glu Val Ile Ala Asp Glu Ser Gin Lys Gly Lys Ala Glu Thr Trp 210 215 220 Tyr Ser Leu Ile Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser Ser Lys 225 230 235 240 Thr Pro Leu Tyr Asp Trp Lys Gly Lys Gin Arg Asp Phe Ile Val Thr Arg Gin Asp Ile Leu Ile Lys Phe Leu Val Glu Gin Thr Gly Leu Lys 485 490 495 Page 1178 of 3790 Gly Lys Pro Leu Ser Ser Val Val Ala Lys Tyr Arg Trp Asn Phe Val 500 505 510 Glu Asp Lys Ile Tyr Pro Cys Asn Glu Thr Gly Thr Gin Ile Arg Thr 515 520 525 Arg Leu Ala Lys Val Glu Asn Thr Pro Glu Asp Phe Leu Thr Ala Glu 530 535 540 Thr Glu Ile Lys Leu Trp His Ile Ile Tyr Ser Val Asn Asp Lys Ala 545 550 555 560 Asp Tyr Glu Lys Ala Leu Lys Thr Phe Ala Glu Lys His Asn Leu Asp 565 570 575 Thr His Ser Phe Val Glu Asn Phe Lys Lys Phe Pro Pro Phe Lys Ser 580 585 590 Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu 595 600 605 Ile Arg Leu Gly Lys Tyr Trp Ser Trp Glu Asn Ile Asp Lys Lys Thr 610 615 620 Gin Glu Arg Ile Glu Lys Ile Leu Thr Gly Glu Phe Asp Glu Ala Ile 625 630 635 640 Lys Ser Arg Val Arg Asp Lys Ala Ile His Leu Thr Glu Glu Asp His 645 650 655 Phe Gin Gly Leu Gin Leu Trp Leu Ala Ser Tyr Val Val Tyr Gly Arg 660 665 670 His Ser Glu Ala Asp Asn Leu Asp Lys Trp His Thr Val Ala Asp Leu 675 680 685 Glu Asp Tyr Leu Ala Glu Phe Arg Gin His Ser Leu Arg Asn Pro Ile 690 695 700 Val Glu Gin Val Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile Trp 705 710 715 720 Leu Gin Tyr Gly Gin Gly Ala Lys Asp Phe Phe Ser Glu Ile His Ile 725 730 735 Glu Leu Ala Arg Glu Met Lys Asn Thr Gly Asp Glu Arg Lys Arg Leu 740 745 750 Page 1179 of 3790 Page 1180 of 3790 Ile Gin Lys Ile Leu Lys Asn Tyr Leu His Ser Lys Glu Asn Lys Page 1182 of 3790 239 1365 PRT Filifactor alocis 239 Met Thr Lys Glu Tyr Tyr Leu Gly Leu Asp Val Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Thr Asp Ser Gin Tyr Asn Leu Cys Lys Phe Lys Lys 20 25 30 Lys Asp Met Trp Gly Ile Arg Leu Phe Glu Ser Ala Asn Thr Ala Lys 35 40 45 Asp Arg Arg Leu Gin Arg Gly Asn Arg Arg Arg Leu Glu Arg Lys Lys 50 55 60 Gin Arg Ile Asp Leu Leu Gin Glu Ile Phe Ser Pro Glu Ile Cys Lys 65 70 75 80 Ile Asp Pro Thr Phe Phe Ile Arg Leu Asn Glu Ser Arg Leu His Leu 85 90 95 Glu Asp Lys Ser Asn Asp Phe Lys Tyr Pro Leu Phe Ile Glu Lys Asp 100 105 110 Tyr Ser Asp Ile Glu Tyr Tyr Lys Glu Phe Pro Thr Ile Phe His Leu 115 120 125 Arg Lys His Leu Ile Glu Ser Glu Glu Lys Gin Asp Ile Arg Leu Ile 130 135 140 Tyr Leu Ala Leu His Asn Ile Ile Lys Thr Arg Gly His Phe Leu Ile 145 150 155 160 Asp Gly Asp Leu Gin Ser Ala Lys Gin Leu Arg Pro Ile Leu Asp Thr 165 170 175 Phe Leu Leu Ser Leu Gin Glu Glu Gin Asn Leu Ser Val Ser Leu Ser 180 185 190 Glu Asn Gin Lys Asp Glu Tyr Glu Glu Ile Leu Lys Asn Arg Ser Ile 195 200 205 Ala Lys Ser Glu Lys Val Lys Lys Leu Lys Asn Leu Phe Glu Ile Ser 210 215 220 Page 1183 of 3790 Asp Glu Leu Glu Lys Glu Glu Lys Lys Ala Gin Ser Ala Val Ile Glu 225 230 235 240 Asn Phe Cys Lys Phe Ile Val Gly Asn Lys Gly Asp Val Cys Lys Phe 245 250 255 Leu Arg Val Ser Lys Glu Glu Leu Glu Ile Asp Ser Phe Ser Phe Ser 260 265 270 Glu Gly Lys Tyr Glu Asp Asp Ile Val Lys Asn Leu Glu Glu Lys Val 275 280 285 Pro Glu Lys Val Tyr Leu Phe Glu Gin Met Lys Ala Met Tyr Asp Trp 290 295 300 Asn Ile Leu Val Asp Ile Leu Glu Thr Glu Glu Tyr Ile Ser Phe Ala 305 310 315 320 Lys Val Lys Gin Tyr Glu Lys His Lys Thr Asn Leu Arg Leu Leu Arg 325 330 335 Asp Ile Ile Leu Lys Tyr Cys Thr Lys Asp Glu Tyr Asn Arg Met Phe 340 345 350 Asn Asp Glu Lys Glu Ala Gly Ser Tyr Thr Ala Tyr Val Gly Lys Leu 355 360 365 Lys Lys Asn Asn Lys Lys Tyr Trp Ile Glu Lys Lys Arg Asn Pro Glu 370 375 380 Glu Phe Tyr Lys Ser Leu Gly Lys Leu Leu Asp Lys Ile Glu Pro Leu 385 390 395 400 Lys Glu Asp Leu Glu Val Leu Thr Met Met Ile Glu Glu Cys Lys Asn 405 410 415 His Thr Leu Leu Pro Ile Gin Lys Asn Lys Asp Asn Gly Val Ile Pro 420 425 430 His Gin Val His Glu Val Glu Leu Lys Lys Ile Leu Glu Asn Ala Lys 435 440 445 Lys Tyr Tyr Ser Phe Leu Thr Glu Thr Asp Lys Asp Gly Tyr Ser Val 450 455 460 Val Gin Lys Ile Glu Ser Ile Phe Arg Phe Arg Ile Pro Tyr Tyr Val 465 470 475 480 Page 1184 of 3790 Gly Pro Leu Ser Thr Arg His Gin Glu Lys Gly Ser Asn Val Trp Met 485 490 495 Val Arg Lys Pro Gly Arg Glu Asp Arg Ile Tyr Pro Trp Asn Met Glu 500 505 510 Glu Ile Ile Asp Phe Glu Lys Ser Asn Glu Asn Phe Ile Thr Arg Met 515 520 525 Thr Asn Lys Cys Thr Tyr Leu Ile Gly Glu Asp Val Leu Pro Lys His 530 535 540 Ser Leu Leu Tyr Ser Lys Tyr Met Val Leu Asn Glu Leu Asn Asn Val 545 550 555 560 Lys Val Arg Gly Lys Lys Leu Pro Thr Ser Leu Lys Gin Lys Val Phe 565 570 575 Glu Asp Leu Phe Glu Asn Lys Ser Lys Val Thr Gly Lys Asn Leu Leu 580 585 590 Glu Tyr Leu Gin Ile Gin Asp Lys Asp Ile Gin Ile Asp Asp Leu Ser 595 600 605 Gly Phe Asp Lys Asp Phe Lys Thr Ser Leu Lys Ser Tyr Leu Asp Phe 610 615 620 Lys Lys Gin Ile Phe Gly Glu Glu Ile Glu Lys Glu Ser Ile Gin Asn 625 630 635 640 Met Ile Glu Asp Ile Ile Lys Trp Ile Thr Ile Tyr Gly Asn Asp Lys 645 650 655 Glu Met Leu Lys Arg Val Ile Arg Ala Asn Tyr Ser Asn Gin Leu Thr 660 665 670 Glu Glu Gin Met Lys Lys Ile Thr Gly Phe Gin Tyr Ser Gly Trp Gly 675 680 685 Asn Phe Ser Lys Met Phe Leu Lys Gly Ile Ser Gly Ser Asp Val Ser 690 695 700 Thr Gly Glu Thr Phe Asp Ile Ile Thr Ala Met Trp Glu Thr Asp Asn 705 710 715 720 Asn Leu Met Gin Ile Leu Ser Lys Lys Phe Thr Phe Met Asp Asn Val 725 730 735 Page 1185 of 3790 Glu Asp Phe Asn Ser Gly Lys Val Gly Lys Ile Asp Lys Ile Thr Tyr 740 745 750 Asp Ser Thr Val Lys Glu Met Phe Leu Ser Pro Glu Asn Lys Arg Ala 755 760 765 Val Trp Gin Thr Ile Gin Val Ala Glu Glu Ile Lys Lys Val Met Gly 770 775 780 Cys Glu Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Gly Glu Lys 785 790 795 800 Val Lys Lys Arg Thr Lys Ser Arg Lys Ala Gin Leu Leu Glu Leu Tyr 805 810 815 Ala Ala Cys Glu Glu Asp Cys Arg Glu Leu Ile Lys Glu Ile Glu Asp 820 825 830 Arg Asp Glu Arg Asp Phe Asn Ser Met Lys Leu Phe Leu Tyr Tyr Thr 835 840 845 Gin Phe Gly Lys Cys Met Tyr Ser Gly Asp Asp Ile Asp Ile Asn Glu 850 855 860 Leu Ile Arg Gly Asn Ser Lys Trp Asp Arg Asp His Ile Tyr Pro Gin 865 870 875 880 Ser Lys Ile Lys Asp Asp Ser Ile Asp Asn Leu Val Leu Val Asn Lys 885 890 895 Thr Tyr Asn Ala Lys Lys Ser Asn Glu Leu Leu Ser Glu Asp Ile Gin 900 905 910 Lys Lys Met His Ser Phe Trp Leu Ser Leu Leu Asn Lys Lys Leu Ile 915 920 925 Thr Lys Ser Lys Tyr Asp Arg Leu Thr Arg Lys Gly Asp Phe Thr Asp 930 935 940 Glu Glu Leu Ser Gly Phe Ile Ala Arg Gin Leu Val Glu Thr Arg Gin 945 950 955 960 Ser Thr Lys Ala Ile Ala Asp Ile Phe Lys Gin Ile Tyr Ser Ser Glu 965 970 975 Val Val Tyr Val Lys Ser Ser Leu Val Ser Asp Phe Arg Lys Lys Pro 980 990 Page 1186 of 3790 985 Leu Asn Tyr Leu Lys Ser Arg Arg Val Asn Asp Tyr His His Ala Lys 995 1000 1005 240 1130 PRT Streptococcus macedonicus 240 Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 15 10 15 Gly Val Gly Ile 20 Ile Glu Ala Lys Thr Gly Lys Val Val 25 His Ala Asn 30 Ser Arg Leu 35 Phe Ser Ala Ala Asn Ala Glu Asn Asn Ala Glu Arg Arg Gly Phe Arg Gly Ser Arg Arg Leu Asn Arg Arg Lys Lys His Arg Val 50 55 60 Page 1188 of 3790 Lys Arg Val Arg Asp Leu Phe Glu Lys Tyr Gly Ile Val Thr Asp Phe 65 70 75 80 Arg Asn Leu Asn Leu Asn Pro Tyr Glu Leu Arg Val Lys Gly Leu Thr 85 90 95 Glu Gin Leu Thr Asn Glu Glu Leu Phe Ala Ala Leu Arg Thr Ile Ser 100 105 110 Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Thr 115 120 125 Gly Ser Thr Asp Tyr Ala Lys Ser Ile Asp Glu Asn Arg Arg Leu Leu 130 135 140 Lys Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Leu Glu Lys Tyr 145 150 155 160 Gly Gin Leu Arg Gly Asn Phe Thr Val Tyr Asp Glu Asn Gly Glu Ala 165 170 175 His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Glu Lys Glu Ala 180 185 190 Arg Lys Ile Leu Glu Thr Gin Ala Asp Tyr Asn Lys Lys Ile Thr Ala 195 200 205 Glu Phe Ile Asp Asp Tyr Val Glu Ile Leu Thr Gin Lys Arg Lys Tyr 210 215 220 Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg Phe 225 230 235 240 Arg Thr Asp Gly Thr Thr Leu Glu Asn Ile Phe Gly Ile Leu Ile Gly 245 250 255 Lys Cys Asn Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser Tyr 260 265 270 Thr Ala Gin Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Lys Val 275 280 285 Pro Thr Glu Thr Gly Lys Leu Ser Thr Glu Gin Lys Glu Ser Leu Val 290 295 300 Glu Phe Ala Lys Asn Thr Ala Ile Leu Gly Pro Ala Lys Leu Leu Lys 305 310 315 320 Page 1189 of 3790 Glu Ile Ala Lys Ile Leu Asp Cys Lys Val Asp Glu Ile Lys Gly Tyr 325 330 335 Arg Glu Asp Asp Lys Gly Lys Pro Asp Leu His Thr Phe Glu Pro Tyr 340 345 350 Arg Lys Leu Lys Phe Asn Leu Asp Ser Val Asn Ile Asp Tyr Leu Ser 355 360 365 Arg Glu Val Leu Asp Lys Leu Ala Asp Ile Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Glu Asp Ala Ile Lys Arg Asn Leu Pro Asn Gin Phe 385 390 395 400 Thr Glu Glu Gin Ile Ser Glu Ile Ile Asn Val Arg Lys Ser Gin Ser 405 410 415 Thr Ala Phe Asn Lys Gly Trp His Ser Phe Ser Ala Lys Leu Met Asn 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Asp Glu Gin Met Thr Ile 435 440 445 Leu Thr Arg Leu Glu Lys Phe Lys Val Lys Lys Lys Ser Ser Lys Asn 450 455 460 Ile Lys Thr Ile Asp Glu Lys Glu Ile Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Val Arg Gin Thr Ile Lys Ile Ile Asn Ala Ala 485 490 495 Val Lys Lys Tyr Gly Asp Phe Asp Lys Ile Val Ile Glu Met Pro Arg 500 505 510 Asp Lys Asn Ala Asp Asp Glu Lys Lys Phe Ile Asn Lys Arg Asn Lys 515 520 525 Glu Asn Lys Lys Glu Lys Asp Asp Ala Leu Lys Arg Ala Ala Tyr Leu 530 535 540 Tyr Asn Gly Thr Asp Lys Leu Pro Asp Glu Val Phe His Gly Asn Lys 545 550 555 560 Gin Leu Glu Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Page 1190 of 3790 Leu Tyr Ser Gly Lys Pro Ile Pro Ile Gin Glu Leu Val His Asn Ser 580 585 590 Asn Asn Phe Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Thr Asn Gin Glu 610 615 620 Lys Gly Gin Lys Thr Pro Tyr Gin Val Ile Asp Ser Met Asp Ala Ala 625 630 635 640 Trp Ser Phe Arg Glu Met Lys Glu Tyr Val Leu Lys Gin Lys Gly Leu 645 650 655 Gly Lys Lys Lys Arg Asp Tyr Leu Leu Thr Thr Glu Asn Ile Asp Lys 660 665 670 Ile Glu Val Lys Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val Val Leu Asn Ser Leu Gin Ser Ala Leu Arg Glu 690 695 700 Leu Gly Lys Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg Lys Trp Lys Ile Asp Lys Ser Arg Glu Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Lys 740 745 750 Leu Trp Glu Lys Gin Asp Asn Pro Met Phe Val Asp Tyr Gly Asn Asn 755 760 765 Gin Val Val Asp Lys Gin Thr Gly Glu Ile Leu Ser Val Ser Asp Asn 770 775 780 Glu Tyr Lys Glu Leu Val Phe Gin Pro Pro Tyr Gin Gly Phe Val Asn 785 790 795 800 Thr Ile Ser Ser Lys Gly Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gin 805 810 815 Val Asp Ser Lys Tyr Asn Arg Lys Val Ser Asp Ala Thr Ile Tyr Ser 820 830 Page 1191 of 3790 825 Page 1192 of 3790 Lys Lys 1130 241 1367 PRT Streptococcus pyogenes 241 Page 1193 of 3790 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Ile Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Page 1194 of 3790 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Page 1195 of 3790 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly His Ser Leu 705 710 715 720 His Glu Gin Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr 755 760 765 Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 770 775 780 Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro Val 785 790 795 800 Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gin 805 810 815 Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg Leu 820 825 830 Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Ile Lys Asp 835 840 845 Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 850 855 860 Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 865 870 875 880 Tyr Trp Arg Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys Phe 885 890 895 Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 900 910 Page 1196 of 3790 905 Page 1197 of 3790 242 1233 PRT Page 1198 of 3790 Mycoplasma canis 242 Met Glu Lys Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Ile Ala 15 10 15 Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gin Val Tyr Lys 20 25 30 Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 35 40 45 Thr Gin Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 50 55 60 Gin Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 65 70 75 80 Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 85 90 95 Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gin Glu Val Cys 100 105 110 Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 115 120 125 Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gin Gin Thr 130 135 140 Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 145 150 155 160 Gly Tyr Phe Lys Gly Ala Leu Ser Gin Pro Thr Glu Ser Glu Met Lys 165 170 175 Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 180 185 190 Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gin Lys Asn Ile 195 200 205 Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 210 215 220 Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 225 230 235 240 Page 1199 of 3790 Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gin Gly Gly Arg Tyr Glu 245 250 255 His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 260 265 270 Gin Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 275 280 285 Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 290 295 300 Gin Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 305 310 315 320 Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 325 330 335 Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 340 345 350 Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 355 360 365 Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 370 375 380 Ser Ala Lys Glu Asn Lys Phe Lys Phe Gin Asp Leu Lys Ile Leu Asn 385 390 395 400 Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 405 410 415 Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 420 425 430 Leu Phe Leu Ile Tyr Gin Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 435 440 445 Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 450 455 460 Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 465 470 475 480 His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Glu Ile 485 490 495 Page 1200 of 3790 Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 500 505 510 Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gin Ile Glu Asp Asn Ser Ser 515 520 525 Leu Met Ala Lys Gin Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 530 535 540 Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gin Gin Ala Ile 545 550 555 560 Leu Ile Phe Asn Lys Ile Ile Gin Lys Phe Ser Lys Asp Phe Glu Ile 565 570 575 Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gin Asp Gin Glu 580 585 590 Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gin Lys Ser Lys Lys Ser 595 600 605 Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 610 615 620 Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 625 630 635 640 Gin Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gin Ile Ser Val Asn Glu 645 650 655 Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 660 665 670 Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gin Ser 675 680 685 Asn Gin Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gin Gly 690 695 700 His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 705 710 715 720 Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 725 730 735 Lys Ser Glu Asn Leu Leu Thr Ala Ser Tyr Asp Gly Tyr Asp Lys Leu Page 1202 of 3790 Asp Glu Ala Ile Asn Ile Lys Tyr Thr Lys Asn Lys Ile Asn Tyr Asn 995 1000 1005 Page 1203 of 3790 243 1375 PRT Lactobacillus johnsonii 243 Met Thr Lys Ile Lys Asp Asp Tyr Ile Val Gly Leu Asp Ile Gly Thr 15 10 15 Asp Ser Cys Gly Trp Val Ala Met Asn Ser Asn Asn Asp Ile Leu Lys 20 25 30 Leu Gin Gly Lys Thr Ala Ile Gly Ser Arg Leu Phe Glu Gly Gly Lys 35 40 45 Ser Ala Ala Glu Arg Arg Leu Phe Arg Thr Thr His Arg Arg Ile Lys 50 55 60 Arg Arg Arg Trp Arg Leu Lys Leu Leu Glu Glu Phe Phe Asp Pro Tyr 65 70 75 80 Met Ala Glu Val Asp Pro Tyr Phe Phe Ala Arg Leu Lys Glu Ser Gly 85 90 95 Leu Ser Pro Leu Asp Lys Arg Lys Thr Val Ser Ser Ile Val Phe Pro 100 105 110 Thr Ser Ala Glu Asp Lys Lys Phe Tyr Asp Asp Tyr Pro Thr Ile Tyr 115 120 125 His Leu Arg Tyr Lys Leu Met Thr Glu Asp Glu Lys Phe Asp Leu Arg 130 135 140 Glu Val Tyr Leu Ala Ile His His Ile Ile Lys Tyr Arg Gly Asn Phe 145 150 155 160 Leu Tyr Asn Thr Ser Val Lys Asp Phe Lys Ala Ser Lys Ile Asp Val 165 170 175 Lys Ser Ser Ile Glu Lys Leu Asn Glu Leu Tyr Glu Asn Leu Gly Leu 180 185 190 Asp Leu Asn Val Glu Phe Asn Ile Ser Asn Thr Ala Glu Ile Glu Lys 195 200 205 Val Leu Lys Asp Lys Gin Ile Phe Lys Arg Asp Lys Val Lys Lys Ile 210 215 220 Page 1204 of 3790 Ala Glu Leu Phe Ala Ile Lys Thr Asp Asn Lys Glu Gin Ser Lys Arg 225 230 235 240 Ile Lys Asp Ile Ser Lys Gin Val Ala Asn Ala Val Leu Gly Tyr Lys 245 250 255 Thr Arg Phe Asp Thr Ile Ala Leu Lys Glu Ile Ser Lys Asp Glu Leu 260 265 270 Ser Asp Trp Asn Phe Lys Leu Ser Asp Ile Asp Ala Asp Ser Lys Phe 275 280 285 Glu Ala Leu Met Gly Asn Leu Asp Glu Asn Glu Gin Ala Ile Leu Leu 290 295 300 Thr Ile Lys Glu Leu Phe Asn Glu Val Thr Leu Asn Gly Ile Val Glu 305 310 315 320 Asp Gly Asn Thr Leu Ser Glu Ser Met Ile Asn Lys Tyr Asn Asp His 325 330 335 Arg Asp Asp Leu Lys Leu Leu Lys Glu Val Ile Glu Asn His Ile Asp 340 345 350 Arg Lys Lys Ala Lys Glu Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 355 360 365 Asn Arg His Gly Gin Leu Leu Gin Ala Lys Lys Lys Leu Gly Lys Ile 370 375 380 Lys Pro Arg Ser Lys Glu Asp Phe Tyr Lys Val Val Asn Lys Asn Leu 385 390 395 400 Asp Asp Ser Arg Ala Ser Lys Glu Ile Lys Lys Lys Ile Glu Leu Asp 405 410 415 Ser Phe Met Pro Lys Gin Arg Thr Asn Ala Asn Gly Val Ile Pro Tyr 420 425 430 Gin Leu Gin Gin Leu Glu Leu Asp Lys Ile Ile Glu Asn Gin Ser Lys 435 440 445 Tyr Tyr Pro Phe Leu Lys Glu Ile Asn Pro Val Ser Ser His Leu Lys 450 455 460 Glu Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 465 470 475 480 Page 1205 of 3790 Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asp Ile Gin 485 490 495 Thr Lys Lys Asn Gin Asn Phe Ala Trp Met Ile Arg Lys Glu Glu Gly 500 505 510 Arg Ile Thr Pro Trp Asn Phe Asp Gin Lys Val Asp Arg Ile Glu Ser 515 520 525 Ala Asn Lys Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Phe 530 535 540 Gly Glu Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gin Lys Phe Thr 545 550 555 560 Val Leu Asn Glu Leu Asn Asn Ile Arg Ile Asn Gly Lys Arg Ile Ser 565 570 575 Val Asp Leu Lys Gin Glu Ile Tyr Glu Asn Leu Phe Lys Lys His Thr 580 585 590 Thr Val Thr Val Lys Lys Leu Glu Asn Tyr Leu Lys Glu Asn His Asn 595 600 605 Leu Val Lys Val Glu Ile Lys Gly Leu Ala Asp Glu Lys Lys Phe Asn 610 615 620 Ser Gly Leu Thr Thr Tyr Asn Arg Phe Lys Asn Leu Asn Ile Phe Asp 625 630 635 640 Asn Gin Ile Asp Asp Leu Lys Tyr Arg Asn Asp Phe Glu Lys Ile Ile 645 650 655 Glu Trp Ser Thr Ile Phe Glu Asp Lys Ser Ile Tyr Lys Glu Lys Leu 660 665 670 Arg Ser Ile Asp Trp Leu Asn Glu Lys Gin Ile Asn Ala Leu Ser Asn 675 680 685 Ile Arg Leu Gin Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Ala Gin 690 695 700 Leu His Asp His Asn Gly Gin Thr Ile Ile Glu Gin Leu Trp Asp Ser 705 710 715 720 Gin Asn Asn Phe Met Gin Ile Val Thr Gin Ala Asp Phe Lys Asp Ala Page 1207 of 3790 Gin Ser Arg Tyr Pro Asn Thr Glu Ile Ile Thr Val Lys Ala Lys Tyr 980 985 990 Asn His Tyr Leu Arg Glu Lys Phe Asp Leu Tyr Lys Ser Arg Glu Val 995 1000 1005 Page 1208 of 3790 1370 1375 244 1053 PRT Staphylococcus aureus 244 Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 15 10 15 Gly Tyr Gly Ile 20 Ile Asp Tyr Glu Thr Arg Asp Val 25 Ile Asp Ala Gly 30 Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 35 40 45 Page 1209 of 3790 Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 50 55 60 Gin Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 65 70 75 80 Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 85 90 95 Ser Gin Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 100 105 110 Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 115 120 125 Gly Asn Glu Leu Ser Thr Lys Glu Gin Ile Ser Arg Asn Ser Lys Ala 130 135 140 Leu Glu Glu Lys Tyr Val Ala Glu Leu Gin Leu Glu Arg Leu Lys Lys 145 150 155 160 Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 165 170 175 Val Lys Glu Ala Lys Gin Leu Leu Lys Val Gin Lys Ala Tyr His Gin 180 185 190 Leu Asp Gin Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 195 200 205 Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 210 215 220 Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 225 230 235 240 Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 245 250 255 Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 260 265 270 Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gin Ile Ile Glu Asn Val Phe 275 280 285 Lys Gin Lys Lys Lys Pro Thr Leu Lys Gin Ile Ala Lys Glu Ile Leu 290 295 300 Page 1210 of 3790 Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 305 310 315 320 Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 325 330 335 Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gin Ile Ala 340 345 350 Lys Ile Leu Thr Ile Tyr Gin Ser Ser Glu Asp Ile Gin Glu Glu Leu 355 360 365 Thr Asn Leu Asn Ser Glu Leu Thr Gin Glu Glu Ile Glu Gin Ile Ser 370 375 380 Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 385 390 395 400 Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gin Ile Ala 405 410 415 Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gin 420 425 430 Gin Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 435 440 445 Val Val Lys Arg Ser Phe Ile Gin Ser Ile Lys Val Ile Asn Ala Ile 450 455 460 Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 465 470 475 480 Glu Lys Asn Ser Lys Asp Ala Gin Lys Met Ile Asn Glu Met Gin Lys 485 490 495 Arg Asn Arg Gin Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 500 505 510 Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 515 520 525 Met Gin Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 530 535 540 Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Page 1212 of 3790 Page 1213 of 3790 245 1063 PRT Simonsiella muelleri 245 Page 1214 of 3790 Asp Asp Leu Leu Met Thr Gin Arg Ser Ala Leu Gin Gly Asp Ala Ile 225 230 235 240 Leu Lys Met Leu Gly His Cys Gly Phe Glu Pro Glu Gin Phe Lys Ala 245 250 255 Ala Lys Asn Thr Phe Ser Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu 260 265 270 Asn Asn Leu Arg Ile Gin Asp Gin Gly Lys Glu Arg Ala Leu Thr Ala 275 280 285 Asp Glu Arg Thr Lys Leu Leu Asp Glu Pro Tyr Lys Lys Ser Lys Leu 290 295 300 Thr Tyr Ala Gin Val Arg Lys Leu Leu Ser Leu Pro Gin Thr Ala Ile 305 310 315 320 Phe Lys Gly Leu Arg Tyr Asp Leu Glu His Asp Lys Lys Ala Glu Asn 325 330 335 Ser Thr Leu Met Glu Met Lys Ser Tyr His Asn Ile Arg Gin Thr Leu 340 345 350 Glu Lys Ser Gly Leu Lys Thr Glu Trp Gin Ser Ile Ala Thr Gin Pro 355 360 365 Glu Ile Leu Asp Ala Ile Gly Thr Ala Phe Ser Ile Tyr Lys Thr Asp 370 375 380 Glu Asp Ile Ser His Glu Leu Lys Thr Cys Arg Leu Pro Glu Asn Val 385 390 395 400 Leu Asn Glu Leu Leu Lys Asn Ile Asn Phe Asp Gly Phe Ile Gin Leu 405 410 415 Ser Leu Thr Ala Leu Arg Lys Ile Leu Pro Leu Met Glu Gin Gly Tyr 420 425 430 Arg Tyr Asp Glu Ala Cys Thr Gin Ile Tyr Gly Asn His His Ser Gly 435 440 445 Ser Leu Gin Gin Glu Ser Lys Gin Phe Leu Pro His Ile Pro Ile Asp 450 455 460 Asp Val Arg Asn Pro Val Val Phe Arg Thr Leu Thr Gin Ala Arg Lys 465 470 475 480 Page 1215 of 3790 Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro Ala Arg Val His 485 490 495 Ile Glu Met Ala Arg Glu Leu Gly Lys Ser Lys Ser Asp Arg Asp Arg 500 505 510 Ile Glu Lys Gin Gin Gin Lys Asn Lys Lys Glu Arg Glu Asn Ala Val 515 520 525 Ala Lys Phe Lys Glu Asp Phe Pro Asp Phe Val Gly Glu Pro Arg Gly 530 535 540 Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Gin Gin His Gly Lys Cys 545 550 555 560 Leu Tyr Ser Gly His Asp Ile Asp Ile Asn Arg Leu Asn Glu Lys Gly 565 570 575 Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 580 585 590 Ser Gin Asn Asn Lys Val Leu Val Leu Gly Ser Glu Asn Gin Asn Lys 595 600 605 Arg Asn Gin Thr Pro Asp Glu Tyr Leu Asp Gly Ala Asn Asn Ser Gin 610 615 620 Arg Trp Leu Glu Phe Gin Ala Arg Val Gin Thr Cys His Phe Ser Tyr 625 630 635 640 Gly Lys Lys Gin Arg Ile Gin Leu Ala Lys Leu Asp Asp Glu Thr Glu 645 650 655 Lys Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg 660 665 670 Phe Met Cys Gin Phe Val Gin Glu Asn Leu Tyr Leu Thr Gly Lys Gly 675 680 685 Lys Arg Leu Val Phe Ala Ser Asn Gly Gly Met Thr Ala Thr Leu Arg 690 695 700 Asn Leu Trp Gly Leu Arg Lys Val Arg Glu Asp Asn Asp Arg His His 705 710 715 720 Ala Leu Asp Ala Ile Val Val Ala Cys Ser Thr Ala Ser Met Gin Gin Ser Glu Ala Asp Trp Asp Leu Ile Asp Glu Ser Phe Glu Phe Lys Phe 965 970 975 Ser Leu Ser Page 1217 of 3790 Arg Gly Asp Leu Val Glu Met Ile Ser Asn Lys Gly Arg 980 985 990 Ile Phe Gly Tyr Tyr Asn Gly Leu Asp Arg Ala Asn Gly Ser Ile Gly 995 1000 1005 1055 1060 246 1509 PRT Psychroflexus torquis 246 Page 1218 of 3790 Phe Met Asn Ser Phe Ile Glu Met Val Ser Glu Phe Lys Asn Ala Gin 130 135 140 Pro Glu Leu Phe Tyr Asn Lys Gly Asn Gly Glu Glu Thr Lys Ile Pro 145 150 155 160 Tyr Asp Trp Thr Leu Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gin Gin 165 170 175 Ile Thr Lys Glu Glu Leu Ala Trp Leu Ile Leu Asn Phe Asn Gin Lys 180 185 190 Arg Gly Tyr Tyr Gin Leu Arg Gly Glu Asp Ile Asp Glu Asp Lys Asn 195 200 205 Lys Lys Tyr Met Gin Leu Lys Val Asn Asn Leu Ile Asp Ser Gly Ala 210 215 220 Lys Val Lys Gly Lys Val Leu Tyr Asn Val Ile Phe Asp Asn Gly Trp 225 230 235 240 Lys Tyr Glu Lys Gin Ile Val Asn Lys Asp Glu Trp Glu Gly Arg Thr 245 250 255 Lys Glu Phe Ile Ile Thr Thr Lys Thr Leu Lys Asn Gly Asn Ile Lys 260 265 270 Arg Thr Tyr Lys Ala Val Asp Ser Glu Ile Asp Trp Ala Ala Ile Lys 275 280 285 Ala Lys Thr Glu Gin Asp Ile Asn Lys Ala Asn Lys Thr Val Gly Glu 290 295 300 Tyr Ile Tyr Glu Ser Leu Leu Asp Asn Pro Ser Gin Lys Ile Arg Gly 305 310 315 320 Lys Leu Val Lys Thr Ile Glu Arg Lys Phe Tyr Lys Glu Glu Phe Glu 325 330 335 Lys Leu Leu Ser Lys Gin Ile Glu Leu Gin Pro Glu Leu Phe Asn Glu 340 345 350 Ser Leu Tyr Lys Ala Cys Ile Lys Glu Leu Tyr Pro Arg Asn Glu Asn 355 360 365 His Gin Ser Asn Asn Lys Lys Gin Gly Phe Glu Tyr Leu Phe Thr Glu 370 375 380 Page 1219 of 3790 Asp Ile Ile Phe Tyr Gin Arg Pro Leu Lys Ser Gin Lys Ser Asn Ile 385 390 395 400 Ser Gly Cys Gin Phe Glu His Lys Ile Tyr Lys Gin Lys Asn Lys Lys 405 410 415 Thr Gly Lys Leu Glu Leu Ile Lys Glu Pro Ile Lys Thr Ile Ser Arg 420 425 430 Ser His Pro Leu Phe Gin Glu Phe Arg Ile Trp Gin Trp Leu Gin Asn 435 440 445 Leu Lys Ile Tyr Asn Lys Glu Lys Ile Glu Asn Gly Lys Leu Glu Asp 450 455 460 Val Thr Thr Gin Leu Leu Pro Asn Asn Glu Ala Tyr Val Thr Leu Phe 465 470 475 480 Asp Phe Leu Asn Thr Lys Lys Glu Leu Glu Gin Lys Gin Phe Ile Glu 485 490 495 Tyr Phe Val Lys Lys Lys Leu Ile Asp Lys Lys Glu Lys Glu His Phe 500 505 510 Arg Trp Asn Phe Val Glu Asp Lys Lys Tyr Pro Phe Ser Glu Thr Arg 515 520 525 Ala Gin Phe Leu Ser Arg Leu Ala Lys Val Lys Gly Ile Lys Asn Thr 530 535 540 Glu Asp Phe Leu Asn Lys Asn Thr Gin Val Gly Ser Lys Glu Asn Ser 545 550 555 560 Pro Phe Ile Lys Arg Ile Glu Gin Leu Trp His Ile Ile Tyr Ser Val 565 570 575 Ser Asp Leu Lys Glu Tyr Glu Lys Ala Leu Glu Lys Phe Ala Glu Lys 580 585 590 His Asn Leu Glu Lys Asp Ser Phe Leu Lys Asn Phe Lys Lys Phe Pro 595 600 605 Pro Phe Val Ser Asp Tyr Ala Ser Tyr Ser Lys Lys Ala Ile Ser Lys 610 615 620 Leu Leu Pro Ile Met Arg Met Gly Lys Tyr Trp Ser Glu Ser Ala Val 625 630 635 640 Page 1220 of 3790 Pro Thr Gin Val Lys Glu Arg Ser Leu Ser Ile Met Glu Arg Val Lys 645 650 655 Val Leu Pro Leu Lys Glu Gly Tyr Ser Asp Lys Asp Leu Ala Asp Leu 660 665 670 Leu Ser Arg Val Ser Asp Asp Asp Ile Pro Lys Gin Leu Ile Lys Ser 675 680 685 Phe Ile Ser Phe Lys Asp Lys Asn Pro Leu Lys Gly Leu Asn Thr Tyr 690 695 700 Gin Ala Asn Tyr Leu Val Tyr Gly Arg His Ser Glu Thr Gly Asp Ile 705 710 715 720 Gin His Trp Lys Thr Pro Glu Asp Ile Asp Arg Tyr Leu Asn Asn Phe 725 730 735 Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin Val Val Met Glu 740 745 750 Thr Leu Arg Val Val Arg Asp Ile Trp Glu His Tyr Gly Asn Asn Glu 755 760 765 Lys Asp Phe Phe Lys Glu Ile His Val Glu Leu Gly Arg Glu Met Lys 770 775 780 Ser Pro Ala Gly Lys Arg Glu Lys Leu Ser Gin Arg Asn Thr Glu Asn 785 790 795 800 Glu Asn Thr Asn His Arg Ile Arg Glu Val Leu Lys Glu Leu Met Asn 805 810 815 Asp Ala Ser Val Glu Gly Gly Val Arg Asp Tyr Ser Pro Ser Gin Gin 820 825 830 Glu Ile Leu Lys Leu Tyr Glu Glu Gly Ile Tyr Gin Asn Pro Asn Thr 835 840 845 Asn Tyr Leu Lys Val Asp Glu Asp Glu Ile Leu Lys Ile Arg Lys Lys 850 855 860 Asn Asn Pro Thr Gin Lys Glu Ile Gin Arg Tyr Lys Leu Trp Leu Glu 865 870 875 880 Gin Gly Tyr Ile Ser Pro Tyr Thr Gly Lys Ile Ile Pro Leu Thr Lys 885 895 Page 1221 of 3790 890 Leu Ser Ala Leu Asn Ala Glu Asn Lys Asn Tyr Ser Leu Arg Asp 1115 1120 1125 Page 1223 of 3790 1505 247 1112 PRT Staphylococcus simulans 247 Met Leu Val Gly Leu Lys Phe Lys Gin Ser Ile Leu Phe Glu Asn Met 15 10 15 Glu Asn Ala Glu Asp Ile Lys Glu Ser Ala Thr Gly Ser Asp Ala Ile 20 25 30 Ser Leu Ser Asp Asp Tyr Tyr Glu Asn Leu Ser Glu Phe Leu Thr Asp 35 40 45 Glu Gin Leu Asn Phe Ile Glu Ser Ala Asn Thr Phe Phe Met Gly Ile 50 55 60 Page 1224 of 3790 Met Leu Asp Arg Ile Leu Lys Gly Ala Thr Ser Ile Ser Ala Ala Lys 65 70 75 80 Val Arg Asp Tyr Lys Ile Phe Lys Ser Gin Leu Lys Leu Ile Lys Asp 85 90 95 Ile Val Tyr Gin Asn Lys Tyr Asp Lys Tyr His Glu Phe Phe Val Thr 100 105 110 Ser Lys Glu Asp Met Arg Ala Tyr Gin Glu Asn Pro Asp Ala Lys Asn 115 120 125 Phe Gly Lys Leu Ser Lys Phe Asp Gin Tyr Leu Ile His Ser Lys Asp 130 135 140 Gin Tyr Ala Lys Leu Met Lys Asp Leu Lys Gly Leu Val Pro Lys Glu 145 150 155 160 Tyr Thr Glu Val Leu Asn Leu Ile Asp Glu Gin Lys Phe Leu Val Val 165 170 175 Gin Asn Thr Thr Asp Asn Ala Ser Ile Pro Tyr Gin Asn Asn Val Phe 180 185 190 Glu Ala Glu Asn Ile Leu Arg Asn Gin Gin Lys Tyr Tyr Pro Glu Ile 195 200 205 Thr Glu Glu Met Ile Gly Lys Val Ile Asn Leu Ile Ser Phe Arg Ile 210 215 220 Pro Tyr Tyr Val Gly Pro Leu Thr Asn Lys Asn Gly Gin Ser Asp Phe 225 230 235 240 Ala Trp Met Ile Arg Lys Ser Asp Glu Gin Thr Leu Pro Trp Asn Phe 245 250 255 Asp Lys Val Ile Asp Lys Ser Lys Ser Ala Glu Lys Phe Ile Arg Arg 260 265 270 Met Thr Ser Lys Cys Thr Tyr Leu Leu Glu Glu Asp Val Leu Pro Lys 275 280 285 His Ser Leu Leu Tyr Gin Glu Met Glu Val Leu Asn Glu Leu Asn Asn 290 295 300 Val Gin Leu Arg Gly Glu Asn Glu Pro Lys His Arg Ile His Arg Leu 305 310 315 320 Page 1225 of 3790 Asp Pro Lys Val Lys Gin Phe Ile Tyr His Asn Leu Phe Gin Lys Lys 325 330 335 Lys Asn Val Thr His Lys Asp Leu Ile Thr Leu Leu Gin Asn Ser Glu 340 345 350 His Arg Asn Thr Leu Asn Lys Thr Ser Gly Gin Lys Leu Lys Val Phe 355 360 365 Gly Thr Gin Asn Asp Ser Lys Phe Ala Ser Lys Leu Ser Thr Tyr Asn 370 375 380 Asp Met Lys Ala Ile Leu Gly Ser Val Glu Asn Lys Arg Gin Met Ile 385 390 395 400 Glu Glu Leu Val Leu Trp Ile Thr Ile Phe Glu Asp Lys Ala Ile Leu 405 410 415 Lys Gin Lys Ile Gly Glu Lys Tyr Pro Asn Ile Thr Glu Lys Gin Leu 420 425 430 Asn Gin Ile Val Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu Ser Glu 435 440 445 Lys Leu Leu Thr Lys Glu Val Asn Gly Arg Ser Leu Ile Asp Leu Met 450 455 460 Tyr Ser Thr Glu Asn Asn Phe Met Glu Ile Ile Thr Asp Lys Thr Leu 465 470 475 480 Gly Phe Asp Cys Phe Ile Lys Asn Ser Asn Lys Val Lys Asn Ala Lys 485 490 495 Ile Ser Tyr Lys Asp Val Ala Glu Leu Arg Thr Ser Pro Ala Leu Lys 500 505 510 Lys Gly Ile Trp Asn Ala Ile Lys Met Val Arg Glu Ile Ser Asn Leu 515 520 525 Phe Gly Ala Pro Glu Lys Ile Ile Ile Glu Phe Ala Thr Glu Asp Gin 530 535 540 Ala Lys Gly Lys Arg Gin Lys Ser Arg Ser Glu Leu Trp Asp Asp Leu 545 550 555 560 Val Lys Lys Asn Asn Leu Lys Arg Asn Lys Glu Phe Glu Gly Leu Phe Page 1227 of 3790 Page 1228 of 3790 248 1274 PRT Mycoplasma gallisept 248 Page 1229 of 3790 Lys Leu Glu Glu Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gin His Trp 180 185 190 Leu Glu Glu Val Lys Lys Val Leu Ser Asn Gin Thr Gly Leu Pro Glu 195 200 205 Lys Phe Lys Glu Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr 210 215 220 Ser Glu Gly Pro Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr 225 230 235 240 His Leu Asp Glu Lys Glu Gly Lys Val Val Gin Lys Tyr Asn Asn Ile 245 250 255 Trp Asp Lys Thr Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg 260 265 270 Ala Pro Lys Asn Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu 275 280 285 Leu Ser Thr Ile Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile 290 295 300 Asn Gin Glu Phe Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu 305 310 315 320 Ile Lys Thr Asn Ser Glu Lys Pro Ile Asp Ala Arg Gin Phe Lys Lys 325 330 335 Leu Arg Glu Glu Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys 340 345 350 Asp Val Glu Ser Glu Glu Lys Leu Glu Lys Asp Asp His Lys Trp Lys 355 360 365 Leu Lys Gly Leu Lys Leu Asn Thr Asn Gly Lys Ile Gin Tyr Asn Asp 370 375 380 Leu Ser Ser Leu Ala Lys Phe Val His Lys Leu Lys Gin His Leu Lys 385 390 395 400 Leu Asp Phe Leu Leu Glu Asp Gin Tyr Thr Pro Leu Asp Lys Ile Asn 405 410 415 Phe Leu Gin Ser Leu Tyr Val Tyr Leu Gly Lys His Leu Arg Tyr Ser 420 425 430 Page 1230 of 3790 Asn Arg Val Asp Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Ser Arg 435 440 445 Leu Phe Glu Arg Val Leu Gin Glu Gin Lys Asp Gly Leu Phe Lys Leu 450 455 460 Phe Glu Gin Thr Asp Lys Asp Asp Glu Lys Ile Leu Thr Gin Thr His 465 470 475 480 Ser Leu Ser Thr Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn 485 490 495 Leu Asp Asn Asp Glu Asp Asn Gin Lys Asn Asn Asp Lys Gly Trp Asn 500 505 510 Phe Glu Ala Ile Lys Asn Phe Asp Gin Lys Phe Ile Asp Ile Thr Lys 515 520 525 Thr Asn Asn Asn Leu Ser Leu Lys Gin Asp Lys Arg Tyr Leu Asp Asp 530 535 540 Gin Phe Ile Asn Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu 545 550 555 560 Arg Glu Ala Thr Lys Val Phe Asn Ala Ile Leu Lys Gin Phe Ser Glu 565 570 575 Glu Tyr Asp Val Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser 580 585 590 Glu Glu Lys Glu Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys 595 600 605 Lys Asn Gly Asp Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ala 610 615 620 Glu Asp Lys Ile Glu Glu Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys 625 630 635 640 Val Leu Leu Trp Leu Gin Gin Asp His Ile Asp Pro Tyr Ser Gin Lys 645 650 655 Glu Ile Ala Phe Asp Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile 660 665 670 Asp His Ile Ile Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Page 1231 of 3790 675 680 685 Lys Leu Leu Val Leu Ala Glu Ser Asn Gin Ala Lys Ser Asn Gin Thr 690 695 700 Pro Tyr Glu Phe Ile Asn Ser Gly Lys Ala Glu Ile Thr Trp Glu Val 705 710 715 720 Tyr Glu Ala Tyr Cys His Lys Phe Lys Asn Gly Asp Ser Ser Leu Leu 725 730 735 Asp Ser Thr Gin Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp 740 745 750 Thr Ser Ser Lys Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp 755 760 765 Thr Arg Tyr Ala Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala 770 775 780 Asn Asn His Leu Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile 785 790 795 800 Asn Gly Gly Val Thr Ser Phe Leu Arg Lys Asn Phe Asp Pro Lys Ser 805 810 815 Trp Tyr Ala Lys Lys Asp Arg Asp Lys Asn Ile His His Ala Val Asp 820 825 830 Ala Ser Ile Ile Ser Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn 835 840 845 Gin Leu Thr Lys Phe Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly 850 855 860 Ser Trp Lys Lys Ile Asp Pro Lys Thr Gly Val Val Ser Glu Val Thr 865 870 875 880 Asp Glu Asn Trp Lys Gin Ile Arg Val Arg Asn Gin Val Ser Glu Ile 885 890 895 Ala Lys Val Ile Asp Lys Tyr Ile Gin Asp Ser Asn Ile Glu Arg Lys 900 905 910 Ala Arg Tyr Ser Arg Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe 915 920 925 Page 1232 of 3790 Page 1233 of 3790 1265 1270 10 15 Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 20 25 30 Arg Ile Phe Pro Ala Ala Gin Ala Glu Asn Asn Leu Val Arg Arg Thr 35 40 45 Asn Arg Gin Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 50 55 60 Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 65 70 75 80 Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gin Leu Arg Val Lys Gly Leu 85 90 95 Page 1234 of 3790 Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 100 105 110 Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 115 120 125 Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser Lys 130 135 140 Gin Leu Glu Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Tyr Gin 145 150 155 160 Thr Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 165 170 175 Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 180 185 190 Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Ser Gin Ile Thr 195 200 205 Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Arg Thr Asn Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gin Lys Asn Gin Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu Lys Val Met Gly Pro Ala Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 325 330 335 His Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 340 345 350 Page 1235 of 3790 Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gin Met Asp 355 360 365 Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Gin Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 385 390 395 400 Phe Ser Gin Lys Gin Val Asp Glu Leu Val Gin Phe Arg Lys Ala Asn 405 410 415 Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 420 425 430 Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr 435 440 445 Ile Leu Thr Arg Leu Gly Lys Gin Lys Thr Thr Ser Ser Ser Asn Lys 450 455 460 Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Val Asn Ala Ala 485 490 495 Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 500 505 510 Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Lys Ile Gin Lys 515 520 525 Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gin 530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 545 550 555 560 Gin Leu Ala Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 580 585 590 Asn Gin Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 595 600 605 Page 1236 of 3790 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu Asp Ser Met Asp Asp Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 645 650 655 Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 660 665 670 Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gin Glu His Phe Arg Ala 690 695 700 His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Asn 740 745 750 Leu Trp Lys Lys Gin Lys Asn Thr Leu Val Ser Tyr Ser Glu Glu Gin 755 760 765 Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 770 775 780 Glu Ser Val Phe Lys Ala Pro Tyr Gin His Phe Val Asp Thr Leu Lys 785 790 795 800 Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp Ser 805 810 815 Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gin 820 825 830 Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 835 840 845 Ile Lys Asp Ile Tyr Thr Gin Asp Gly Tyr Asp Ala Phe Met Lys Ile 980 985 990 Lys Lys Thr Gly Thr Tyr Lys 995 Ile Ser Gin Glu Lys Tyr Asn Gly Ile 1000 1005 Glu Gin 1040 Gin Leu Phe Arg Phe 1045 Leu Ser Arg Thr Met 1050 Pro Asn Val Lys Tyr 1055 Tyr Val Glu Leu Lys 1060 Pro Tyr Ser Lys Asp 1065 Lys Phe Glu Lys Asn 1070 Glu Ser Leu Ile Glu 1075 Ile Leu Gly Ser Ala 1080 Asp Lys Ser Gly Arg Cys Ile Lys Gly Leu Gly Lys Ser Asn Ile Ser Ile Tyr 1085 1090 1095 Page 1238 of 3790 Lys Val Arg Thr Asp Val Leu Gly Asn Gin His Ile Ile Lys Asn 1100 1105 1110 Glu Gly Asp Lys Pro Lys Leu Asp Phe 1115 1120 250 1236 PRT Artificial Sequence Synthetic amino acid sequence 250 Met Tyr Phe Tyr Lys Asn Lys Glu 1 5 Asn Lys Leu Asn Lys Lys Val Val 10 15 Leu Gly Leu Asp Leu Gly Ile Ala 20 Ser Val Gly Trp Cys Leu Thr Asp 25 30 Ile Ser Gin Lys Glu Asp Asn Lys 35 40 Phe Pro Ile Ile Leu His Gly Val 45 Arg Leu Phe Glu Thr Val Asp Asp 50 55 Ser Asp Asp Lys Leu Leu Asn Glu 60 Thr Arg Arg Lys Lys Arg Gly Gin 65 70 Arg Arg Arg Asn Arg Arg Leu Phe 75 80 Thr Arg Lys Arg Asp Phe Ile Lys 85 Tyr Leu Ile Asp Asn Asn Ile Ile 90 95 Glu Leu Glu Phe Asp Lys Asn Pro 100 Lys Ile Leu Val Arg Asn Phe Ile 105 110 Glu Lys Tyr Ile Asn Pro Phe Ser 115 120 Lys Asn Leu Glu Leu Lys Tyr Lys 125 Ser Val Thr Asn Leu Pro Ile Gly 130 135 Phe His Asn Leu Arg Lys Ala Ala 140 Ile Asn Glu Lys Tyr Lys Leu Asp 145 150 Lys Ser Glu Leu Ile Val Leu Leu 155 160 Tyr Phe Tyr Leu Ser Leu Arg Gly Ala 165 Phe 170 Phe Asp Asn Pro Glu Asp 175 Thr Lys Ser Lys Glu Met Asn Lys Asn Glu Ile Glu Ile Phe Asp Lys 405 410 415 Ile Asn Phe Glu Asn Tyr Leu Ile Ser Asn Glu Asn Asp Leu Ser Lys 420 425 430 Page 1240 of 3790 Leu Met Ser Phe Tyr Lys Gin Gin Ser Glu Lys Leu Phe Val Pro Asn 435 440 445 Glu Lys Gly Ser Tyr Glu Ile Asn Gin Asn Asn Asn Val Leu His Ile 450 455 460 Phe Asp Ala Ile Ser Asn Ile Leu Asn Lys Phe Ser Thr Ile Gin Asp 465 470 475 480 Arg Ile Arg Ile Leu Glu Gly Tyr Phe Glu Phe Ser Asn Leu Lys Lys 485 490 495 Asp Val Lys Ser Ser Glu Ile Tyr Ser Glu Ile Ala Lys Leu Arg Glu 500 505 510 Phe Ser Gly Thr Ser Ser Leu Ser Phe Gly Ala Tyr Tyr Lys Phe Ile 515 520 525 Pro Asn Leu Ile Ser Glu Gly Ser Lys Asn Tyr Ser Thr Ile Ser Tyr 530 535 540 Glu Glu Lys Ala Leu Gin Asn Gin Lys Asn Asn Phe Ser His Ser Asn 545 550 555 560 Leu Phe Glu Lys Thr Trp Val Glu Asp Leu Ile Ala Ser Pro Thr Val 565 570 575 Lys Arg Ser Leu Arg Gin Thr Met Asn Leu Leu Lys Glu Ile Phe Lys 580 585 590 Tyr Ser Glu Lys Asn Asn Leu Glu Ile Glu Lys Ile Val Val Glu Val 595 600 605 Thr Arg Ser Ser Asn Asn Lys His Glu Arg Lys Lys Ile Glu Gly Ile 610 615 620 Asn Lys Tyr Arg Lys Glu Lys Tyr Glu Glu Leu Lys Lys Val Tyr Asp 625 630 635 640 Leu Pro Asn Glu Asn Thr Thr Leu Leu Lys Lys Leu Trp Leu Leu Arg 645 650 655 Gin Gin Gin Gly Tyr Asp Ala Tyr Ser Leu Arg Lys Ile Glu Ala Asn 660 665 670 Asp Val Ile Asn Lys Pro Trp Asn Tyr Asp Ile Asp His Ile Val Pro 675 680 685 Page 1241 of 3790 Arg Ser Ile Ser Phe Asp Asp Ser Phe Ser Asn Leu Val Ile Val Asn 690 695 700 Lys Leu Asp Asn Ala Lys Lys Ser Asn Asp Leu Ser Ala Lys Gin Phe 705 710 715 720 Ile Glu Lys Ile Tyr Gly Ile Glu Lys Leu Lys Glu Ala Lys Glu Asn 725 730 735 Trp Gly Asn Trp Tyr Leu Arg Asn Ala Asn Gly Lys Ala Phe Asn Asp 740 745 750 Lys Gly Lys Phe Ile Lys Leu Tyr Thr Ile Asp Asn Leu Asp Glu Phe 755 760 765 Asp Asn Ser Asp Phe Ile Asn Arg Asn Leu Ser Asp Thr Ser Tyr Ile 770 775 780 Thr Asn Ala Leu Val Asn His Leu Thr Phe Ser Asn Ser Lys Tyr Lys 785 790 795 800 Tyr Ser Val Val Ser Val Asn Gly Lys Gin Thr Ser Asn Leu Arg Asn 805 810 815 Gin Ile Ala Phe Val Gly Ile Lys Asn Asn Lys Glu Thr Glu Arg Glu 820 825 830 Trp Lys Arg Pro Glu Gly Phe Lys Ser Ile Asn Ser Asn Asp Phe Leu 835 840 845 Ile Arg Glu Glu Gly Lys Asn Asp Val Lys Asp Asp Val Leu Ile Lys 850 855 860 Asp Arg Ser Phe Asn Gly His His Ala Glu Asp Ala Tyr Phe Ile Thr 865 870 875 880 Ile Ile Ser Gin Tyr Phe Arg Ser Phe Lys Arg Ile Glu Arg Leu Asn 885 890 895 Val Asn Tyr Arg Lys Glu Thr Arg Glu Leu Asp Asp Leu Glu Lys Asn 900 905 910 Asn Ile Lys Phe Lys Glu Lys Ala Ser Phe Asp Asn Phe Leu Leu Ile 915 920 925 Asn Ala Leu Asp Glu Leu Asn Glu Lys Leu Asn Gin Met Arg Phe Ser 930 935 940 Page 1242 of 3790 Leu Phe Glu Asn Glu Glu Lys Glu Leu Phe Tyr Ile Val Gly Arg Phe Lys Lys 1235 251 1059 PRT Artificial Sequence Synthetic amino acid sequence 251 Met Ile Glu Arg Ile Leu Gly Val Asp Leu Gly Ile Ser Ser Leu Gly 15 10 15 Trp Ala Ile Val Glu Tyr Asp Lys Asp Asp Glu Ala Ala Asn Arg Ile 20 25 30 Ile Asp Cys Gly Val Arg Leu Phe Thr Ala Ala Glu Thr Pro Lys Lys 35 40 45 Lys Glu Ser Pro Asn Lys Ala Arg Arg Glu Ala Arg Gly Ile Arg Arg 50 55 60 Val Leu Asn Arg Arg Arg Val Arg Met Asn Met Ile Lys Lys Leu Phe 65 70 75 80 Leu Arg Ala Gly Leu Ile Gin Asp Val Asp Leu Asp Gly Glu Gly Gly 85 90 95 Met Phe Tyr Ser Lys Ala Asn Arg Ala Asp Val Trp Glu Leu Arg His 100 105 110 Asp Gly Leu Tyr Arg Leu Leu Lys Gly Asp Glu Leu Ala Arg Val Leu 115 120 125 Ile His Ile Ala Lys His Arg Gly Tyr Lys Phe Ile Gly Asp Asp Glu 130 135 140 Page 1244 of 3790 Ala Asp Glu Glu Ser Gly Lys Val Lys Lys Ala Gly Val Val Leu Arg 145 150 155 160 Gin Asn Phe Glu Ala Ala Gly Cys Arg Thr Val Gly Glu Trp Leu Trp 165 170 175 Arg Glu Arg Gly Ala Asn Gly Lys Lys Arg Asn Lys His Gly Asp Tyr 180 185 190 Glu Ile Ser Ile His Arg Asp Leu Leu Val Glu Glu Val Glu Ala Ile 195 200 205 Phe Val Ala Gin Gin Glu Met Arg Ser Thr Ile Ala Thr Asp Ala Leu 210 215 220 Lys Ala Ala Tyr Arg Glu Ile Ala Phe Phe Val Arg Pro Met Gin Arg 225 230 235 240 Ile Glu Lys Met Val Gly His Cys Thr Tyr Phe Pro Glu Glu Arg Arg 245 250 255 Ala Pro Lys Ser Ala Pro Thr Ala Glu Lys Phe Ile Ala Ile Ser Lys 260 265 270 Phe Phe Ser Thr Val Ile Ile Asp Asn Glu Gly Trp Glu Gin Lys Ile 275 280 285 Ile Glu Arg Lys Thr Leu Glu Glu Leu Leu Asp Phe Ala Val Ser Arg 290 295 300 Glu Lys Val Glu Phe Arg His Leu Arg Lys Phe Leu Asp Leu Ser Asp 305 310 315 320 Asn Glu Ile Phe Lys Gly Leu His Tyr Lys Gly Lys Pro Lys Thr Ala 325 330 335 Lys Lys Arg Glu Ala Thr Leu Phe Asp Pro Asn Glu Pro Thr Glu Leu 340 345 350 Glu Phe Asp Lys Val Glu Ala Glu Lys Lys Ala Trp Ile Ser Leu Arg 355 360 365 Gly Ala Ala Lys Leu Arg Glu Ala Leu Gly Asn Glu Phe Tyr Gly Arg 370 375 380 Phe Val Ala Leu Gly Lys His Ala Asp Glu Ala Thr Lys Ile Leu Thr Page 1246 of 3790 Glu Thr Arg Thr Ser Ala Pro Ser Asn Arg Val Arg Thr Gly Lys Gly 645 650 655 Lys Ile Asp Arg Leu Leu Lys Lys Asn Phe Asp Glu Asn Ser Glu Met 660 665 670 Ala Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Met Ala Arg Ala 675 680 685 Ile Lys Thr Tyr Cys Glu Gin Tyr Trp Val Phe Lys Asn Ser His Thr 690 695 700 Lys Ala Pro Val Gin Val Arg Ser Gly Lys Leu Thr Ser Val Leu Arg 705 710 715 720 Tyr Gin Trp Gly Leu Glu Ser Lys Asp Arg Glu Ser His Thr His His 725 730 735 Ala Val Asp Ala Ile Ile Ile Ala Phe Ser Thr Gin Gly Met Val Gin 740 745 750 Lys Leu Ser Glu Tyr Tyr Arg Phe Lys Glu Thr His Arg Glu Lys Glu 755 760 765 Arg Pro Lys Leu Ala Val Pro Leu Ala Asn Phe Arg Asp Ala Val Glu 770 775 780 Glu Ala Thr Arg Ile Glu Asn Thr Glu Thr Val Lys Glu Gly Val Glu 785 790 795 800 Val Lys Arg Leu Leu Ile Ser Arg Pro Pro Arg Ala Arg Val Thr Gly 805 810 815 Gin Ala His Glu Gin Thr Ala Lys Pro Tyr Pro Arg Ile Lys Gin Val 820 825 830 Lys Asn Lys Lys Lys Trp Arg Leu Ala Pro Ile Asp Glu Glu Lys Phe 835 840 845 Glu Ser Phe Lys Ala Asp Arg Val Ala Ser Ala Asn Gin Lys Asn Phe 850 855 860 Tyr Glu Thr Ser Thr Ile Pro Arg Val Asp Val Tyr His Lys Lys Gly 865 870 875 880 Lys Phe His Leu Val Pro Ile Tyr Leu His Glu Met Val Leu Asn Glu 885 890 895 Page 1247 of 3790 1055 Leu Ala Met Asn Lys Asn Glu Ile Leu Arg Gly Ser Ser Val Leu Tyr 20 25 30 Page 1248 of 3790 Arg Leu Gly Leu Asp Leu Gly Ser Asn Ser Leu Gly Trp Phe Val Thr 35 40 45 His Leu Glu Lys Arg Gly Asp Arg His Glu Pro Val Ala Leu Gly Pro 50 55 60 Gly Gly Val Arg Ile Phe Pro Asp Gly Arg Asp Pro Gin Ser Gly Thr 65 70 75 80 Ser Asn Ala Val Asp Arg Arg Met Ala Arg Gly Ala Arg Lys Arg Arg 85 90 95 Asp Arg Phe Val Glu Arg Arg Lys Glu Leu Ile Ala Ala Leu Ile Lys 100 105 110 Tyr Asn Leu Leu Pro Asp Asp Ala Arg Glu Arg Arg Ala Leu Glu Val 115 120 125 Leu Asp Pro Tyr Ala Leu Arg Lys Thr Ala Leu Thr Asp Thr Leu Pro 130 135 140 Ala His His Val Gly Arg Ala Leu Phe His Leu Asn Gin Arg Arg Gly 145 150 155 160 Phe Gin Ser Asn Arg Lys Thr Asp Ser Lys Gin Ser Glu Asp Gly Ala 165 170 175 Ile Lys Gin Ala Ala Ser Arg Leu Ala Thr Asp Lys Gly Asn Glu Thr 180 185 190 Leu Gly Val Phe Phe Ala Asp Met His Leu Arg Lys Ser Tyr Glu Asp 195 200 205 Arg Gin Thr Ala Ile Arg Ala Glu Leu Val Arg Leu Gly Lys Asp His 210 215 220 Leu Thr Gly Asn Ala Arg Lys Lys Ile Trp Ala Lys Val Arg Lys Arg 225 230 235 240 Leu Phe Gly Asp Glu Val Leu Pro Arg Ala Asp Ala Pro His Gly Val 245 250 255 Arg Ala Arg Ala Thr Ile Thr Gly Thr Lys Ala Ser Tyr Asp Tyr Tyr 260 265 270 Pro Thr Arg Asp Met Leu Arg Asp Glu Phe Asn Ala Ile Trp Ala Gly 275 280 285 Page 1249 of 3790 Gin Ser Ala His His Ala Thr Ile Thr Asp Glu Ala Arg Thr Glu Ile 290 295 300 Glu His Ile Ile Phe Tyr Gin Arg Pro Leu Lys Pro Ala Ile Val Gly 305 310 315 320 Lys Cys Thr Leu Asp Pro Ala Thr Arg Pro Phe Lys Glu Asp Pro Glu 325 330 335 Gly Tyr Arg Ala Pro Trp Ser His Pro Leu Ala Gin Arg Phe Arg Ile 340 345 350 Leu Ser Glu Ala Arg Asn Leu Glu Ile Arg Asp Thr Gly Lys Gly Ser 355 360 365 Arg Arg Leu Thr Lys Glu Gin Ser Asp Leu Val Val Ala Ala Leu Leu 370 375 380 Ala Asn Arg Glu Val Lys Phe Asp Lys Leu Arg Thr Leu Leu Lys Leu 385 390 395 400 Pro Ala Glu Ala Arg Phe Asn Leu Glu Ser Asp Arg Arg Ala Ala Leu 405 410 415 Asp Gly Asp Gin Thr Ala Ala Arg Leu Ser Asp Lys Lys Gly Phe Asn 420 425 430 Lys Ala Trp Arg Gly Phe Pro Pro Glu Arg Gin Ile Ala Ile Val Ala 435 440 445 Arg Leu Glu Glu Thr Glu Asp Glu Asn Glu Leu Ile Ala Trp Leu Glu 450 455 460 Lys Glu Cys Ala Leu Asp Gly Ala Ala Ala Ala Arg Val Ala Asn Thr 465 470 475 480 Thr Leu Pro Asp Gly His Cys Arg Leu Gly Leu Arg Ala Ile Lys Lys 485 490 495 Ile Val Pro Ile Met Gin Asp Gly Leu Asp Glu Asp Gly Val Ala Gly 500 505 510 Ala Gly Tyr His 515 Ile Ala Ala Lys 520 Arg Ala Gly Tyr Asp His 525 Ala Lys Leu Pro Thr Gly Glu Gin Leu Gly Arg Leu Pro Tyr Tyr Gly Gin Trp 530 535 540 Page 1250 of 3790 Leu Gin Asp Ala Val Val Gly Ser Gly Asp Ala Arg Asp Gin Lys Glu 545 550 555 560 Lys Gin Tyr Gly Gin Phe Pro Asn Pro Thr Val His Ile Gly Leu Gly 565 570 575 Gin Leu Arg Arg Val Val Asn Asp Leu Ile Asp Lys Tyr Gly Pro Pro 580 585 590 Thr Glu Ile Ser Ile Glu Phe Thr Arg Ala Leu Lys Leu Ser Glu Gin 595 600 605 Gin Lys Ala Glu Arg Gin Arg Glu Gin Arg Arg Asn Gin Asp Lys Asn 610 615 620 Lys Ala Arg Ala Glu Glu Leu Ala Lys Phe Gly Arg Pro Ala Asn Pro 625 630 635 640 Arg Asn Leu Leu Lys Met Arg Leu Trp Glu Glu Leu Ala His Asp Pro 645 650 655 Leu Asp Arg Lys Cys Val Tyr Thr Gly Glu Gin Ile Ser Ile Glu Arg 660 665 670 Leu Leu Ser Asp Glu Val Asp Ile Asp His Ile Leu Pro Val Ala Met 675 680 685 Thr Leu Asp Asp Ser Pro Ala Asn Lys Ile Ile Cys Met Arg Tyr Ala 690 695 700 Asn Arg His Lys Arg Lys Gin Thr Pro Ser Glu Ala Phe Gly Ser Ser 705 710 715 720 Pro Thr Leu Gin Gly His Arg Tyr Asn Trp Asp Asp Ile Ala Ala Arg 725 730 735 Ala Thr Gly Leu Pro Arg Asn Lys Arg Trp Arg Phe Asp Ala Asn Ala 740 745 750 Arg Glu Glu Phe Asp Lys Arg Gly Gly Phe Leu Ala Arg Gin Leu Asn 755 760 765 Glu Thr Gly Trp Leu Ala Arg Leu Ala Lys Gin Tyr Leu Gly Ala Val 770 775 780 Thr Asp Pro Asn Gin Ile Trp Val Val Pro Gly Arg Leu Thr Ser Met 980 985 990 Lys His Gly Leu Arg His Val Arg Ile Leu Lys Lys Glu Lys Gly Asp 995 1000 1005 Tyr Leu Val Pro Ile Ala Asn Arg Ala Ser Gly Val Ala Tyr Lys 1010 1015 1020 Ala Tyr Ser Ala Gly Glu Asn Phe Cys Val Glu Val Phe Glu Thr 1025 1030 1035 Trp Ala Val Ile Gly Asp Asp Phe Lys 20 25 Ile Lys Arg Lys Lys 30 Gly Lys Asn Leu Ile Gly Val Arg Leu Phe Lys Glu Gly Asp Thr Ala Ala Glu 45 Arg Arg Gly 50 Phe Arg Thr Gin Arg Arg Arg 55 Leu Asn Arg Arg 60 Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Met Ala Glu Val Page 1254 of 3790 Met His Lys Ala His Leu Lys Met Tyr Lys Glu Phe Ile Asn Thr Leu 325 330 335 Asn Ala Lys Asp Arg Lys Ile Leu Lys Asn Ala Tyr Ser Asp Tyr Ile 340 345 350 Asn Asn Glu Lys Ala Lys Ala Ala Asn Ala Gin Glu Asn Phe Tyr Lys 355 360 365 Thr Val Lys Lys Thr Ile Lys Glu Asn Asp Ser Asp Thr Ala Lys Lys 370 375 380 Ile Ile Gly Leu Ile Asp Glu Gly Asn Phe Met Pro Lys Gin Arg Thr 385 390 395 400 Gly Glu Asn Gly Val Ile Pro His Gin Leu His Gin Ile Glu Leu Asp 405 410 415 Arg Ile Ile Glu Asn Gin Ala Lys Tyr Tyr Pro Trp Leu Ala Glu Glu 420 425 430 Asn Pro Val Glu Lys Asn Arg Lys Phe Ala Lys Tyr Lys Leu Asp Glu 435 440 445 Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Asp Lys 450 455 460 Thr Glu Ser Asn Lys Asn Glu Lys Glu Thr Lys Phe Ala Trp Met Val 465 470 475 480 Arg Lys Ala Lys Gly Thr Ile Thr Pro Trp Asn Phe Glu Asn Leu Val 485 490 495 Asp Arg Thr Glu Ser Ala Asn Arg Phe Ile Lys Arg Met Thr Ser Lys 500 505 510 Asp Thr Tyr Ile Ile Gly Glu Asp Val Leu Pro Ala Ser Ser Leu Leu 515 520 525 Tyr Glu Lys Tyr Lys Val Leu Asn Glu Leu Asn Asn Ile Lys Val Asn 530 535 540 Lys Lys Lys Leu Asp Val Glu Gin Lys Gin His Val Tyr Leu Asp Leu 545 550 555 560 Phe Thr Thr Arg Lys Asn Val Thr Lys Asp Asp Leu Ala Thr Ser Leu 565 570 575 Page 1255 of 3790 Asn Cys Asp Val Glu Ser Ile Thr Gly Leu Thr Asp Asn Lys Lys Phe 580 585 590 Asn Ser Ser Leu Ser Ser Tyr Ile Asp Leu Lys Ala Ile Leu Gly Asn 595 600 605 Ile Val Asp Asp Tyr Ser Lys Asn Glu Asp Leu Glu Lys Ile Ile Glu 610 615 620 Tyr Ser Thr Ile Phe Glu Asp Gly Asn Ile Tyr Lys Glu Lys Leu Ser 625 630 635 640 Glu Ile Ser Trp Leu Thr Asp Glu Gin Ile Glu Lys Leu Ser Asn Ile 645 650 655 His Phe Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gin Ile 660 665 670 Thr Asn Glu Asn Gly Glu Arg Ile Ile Asp Thr Leu Trp Asn Thr Ser 675 680 685 Asn Asn Phe Ile Gin Val Ile Ser Asp Glu Ser Ile Gin Ala Lys Leu 690 695 700 Ala Glu Ile Asn Gly Glu Tyr Ala Asn Lys Tyr Asn Leu Glu Asp Ile 705 710 715 720 Leu Asp Glu Ala Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg Gin 725 730 735 Val Met Lys Val Val Glu Asp Ile Glu Lys Ala Met Lys Cys Glu Pro 740 745 750 Thr Ser Ile Ala Ile Glu Phe Thr Arg Glu Lys Arg Lys Ser Lys Leu 755 760 765 Thr Asn Thr Arg Tyr Lys Lys Ile Ser Glu Thr Tyr Glu Lys Ile Thr 770 775 780 Asp Glu Leu Ile Ser Glu Tyr Glu Leu Gly Lys Leu Gin Ser Glu Leu 785 790 795 800 Asp Ser Lys Val Asn Asn Met Arg Asp Arg Tyr Tyr Leu Tyr Phe Met 805 810 815 Gin Leu Gly Arg Asp Met Tyr Thr Gly Glu Lys Met Asn Ile Asp Glu 820 825 830 Page 1256 of 3790 Asn Gly Ala Phe Tyr Asp Gin Thr Lys Tyr Asn Ala Lys Thr Ile 1145 254 1314 PRT Artificial Sequence Synthetic amino acid sequence 254 Met Leu Arg Leu Tyr Cys Ala Asn Asn Leu Val Leu Asn Asn Val Gin 15 10 15 Asn Leu Trp Lys Tyr Leu Leu Leu Leu Ile Phe Asp Lys Lys Ile Ile 20 25 30 Phe Leu Phe Lys Ile Lys Val Ile Leu Ile Arg Arg Tyr Met Glu Asn 35 40 45 Asn Asn Lys Glu Lys Ile Val Ile Gly Phe Asp Leu Gly Val Ala Ser 50 55 60 Val Gly Trp Ser Ile Val Asn Ala Glu Thr Lys Glu Val Ile Asp Leu 65 70 75 80 Gly Val Arg Leu Phe Ser Glu Pro Glu Lys Ala Asp Tyr Arg Arg Ala 85 90 95 Lys Arg Thr Thr Arg Arg Leu Leu Arg Arg Lys Lys Phe Lys Arg Glu 100 105 110 Lys Phe His Lys Leu Ile Leu Lys Asn Ala Glu Ile Phe Gly Leu Gin 115 120 125 Page 1258 of 3790 Ser Arg Asn Glu Ile Leu Asn Val Tyr Lys Asp Gin Ser Ser Lys Tyr 130 135 140 Arg Asn Ile Leu Lys Leu Lys Ile Asn Ala Leu Lys Glu Glu Ile Lys 145 150 155 160 Pro Ser Glu Leu Val Trp Ile Leu Arg Asp Tyr Leu Gin Asn Arg Gly 165 170 175 Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp Glu Phe Val Ser Asn Ser 180 185 190 Phe Pro Ser Lys Lys Leu His Glu His Tyr Glu Lys Tyr Gly Phe Phe 195 200 205 Arg Gly Ser Val Lys Leu Asp Asn Lys Leu Asp Asn Lys Lys Asp Lys 210 215 220 Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser Asp Ala Lys Lys Glu Ser 225 230 235 240 Glu Glu Leu Ile Phe Ser Asn Lys Gin Trp Ile Asn Glu Ile Val Lys 245 250 255 Val Phe Glu Asn Gin Ser Tyr Leu Thr Glu Ser Phe Lys Glu Glu Tyr 260 265 270 Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe Asn Lys Gly Pro Gly Ser 275 280 285 Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe Ser Thr Asp Ile Asp Pro 290 295 300 Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn Ile Trp Asp Lys Thr Ile 305 310 315 320 Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile Arg Ala Pro Lys Asn Leu 325 330 335 Pro Ser Ala Leu Ile Phe Asn Leu Gin Asn Glu Ile Cys Thr Ile Lys 340 345 350 Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp Leu Asn Ala Glu Gin Lys 355 360 365 Ser Glu Ile Leu Lys Phe Val Phe Thr Glu Leu Phe Asn Trp Lys Asp Page 1260 of 3790 Gin Ile Ile Lys Asn Phe Gly Lys Lys Tyr Glu Ile Ser Gin Val Val 625 630 635 640 Ile Glu Met Ala Arg Glu Leu Thr Lys Pro Asn Leu Glu Lys Leu Leu 645 650 655 Asn Asn Ala Thr Asn Ser Asn Ile Lys Ile Leu Lys Glu Lys Leu Asp 660 665 670 Gin Thr Glu Lys Phe Asp Asp Phe Thr Lys Lys Lys Phe Ile Asp Lys 675 680 685 Ile Glu Asn Ser Val Val Phe Arg Asn Lys Leu Phe Leu Trp Phe Glu 690 695 700 Gin Asp Arg Lys Asp Pro Tyr Thr Gin Leu Asp Ile Lys Ile Asn Glu 705 710 715 720 Ile Glu Asp Glu Thr Glu Ile Asp His Val Ile Pro Tyr Ser Lys Ser 725 730 735 Ala Asp Asp Ser Trp Phe Asn Lys Leu Leu Val Lys Lys Ser Thr Asn 740 745 750 Gin Leu Lys Lys Asn Lys Thr Val Trp Glu Tyr Tyr Gin Asn Glu Ser 755 760 765 Asp Pro Glu Ala Lys Trp Asn Lys Phe Val Ala Trp Ala Lys Arg Ile 770 775 780 Tyr Leu Val Gin Lys Ser Asp Lys Glu Ser Lys Asp Asn Ser Glu Lys 785 790 795 800 Asn Ser Ile Phe Lys Asn Lys Lys Pro Asn Leu Lys Phe Lys Asn Ile 805 810 815 Thr Lys Lys Leu Phe Asp Pro Tyr Lys Asp Leu Gly Phe Leu Ala Arg 820 825 830 Asn Leu Asn Asp Thr Arg Tyr Ala Thr Lys Val Phe Arg Asp Gin Leu 835 840 845 Asn Asn Tyr Ser Lys His His Ser Lys Asp Asp Glu Asn Lys Leu Phe 850 855 860 Lys Val Val Cys Met Asn Gly Ser Ile Thr Ser Phe Leu Arg Lys Ser 865 870 875 880 Page 1261 of 3790 Ser Leu Ile Leu Thr Phe Asp Ala Ile Lys His Asn Asp Pro Lys 1115 1120 1125 Page 1262 of 3790 1310 Page 1263 of 3790 Met Ser Glu Cys Val Thr Arg Arg Ile Leu Gly Ile Asp Leu Gly Ile 15 10 15 Ala Ser Cys Gly Trp Gly Val Ile Glu Val Gly Glu Ala Ser Gly Ser 20 25 30 Ile Ile Ala Ser Gly Val Arg Cys Phe Asp Ala Pro Leu Ile Asp Lys 35 40 45 Thr Gly Glu Pro Lys Ser Ala Thr Arg Arg Thr Ala Arg Gly Gin Arg 50 55 60 Arg Ile Ile Arg Arg Arg Arg Gin Arg Met Asn Ala Val Arg Arg Leu 65 70 75 80 Leu Ala Glu Phe Gly Val Leu Thr Gly Arg Ser Pro Asp Ala Leu His 85 90 95 Gin Ala Leu Leu Arg Leu Ser Gin Ser Val Ala Gly Ser Gin Val Thr 100 105 110 Pro Trp Thr Leu Arg Ala Ala Ala His Glu Arg Lys Leu Thr Asn Asp 115 120 125 Glu Leu Ala Val Val Leu Gly His Ile Ala Arg His Arg Gly Phe Arg 130 135 140 Ser Asn Ser Lys Asn Asp Gly Gly Ala Asn Ala Ala Asp Glu Thr Ser 145 150 155 160 Lys Met Lys Lys Ala Met Glu Thr Thr Arg Glu Gly Leu Ala Arg Tyr 165 170 175 His Ser Phe Gly Ala Met Ile Ala Ser Asp Pro Lys Phe Ala Asp Arg 180 185 190 Lys Arg Asn Arg Asp Lys Asp Tyr Ser His Thr Ala Lys Arg Ser Asp 195 200 205 Leu Glu Asp Glu Val Arg Thr Ile Phe Arg Ser Gin Thr Arg Phe Gly 210 215 220 Ser Leu Val Ala Ser Glu Lys Leu Ser Gin Ala Phe Ala Asp Ala Ala 225 230 235 240 Phe Phe Gin Arg Pro Leu Gin Asp Ser Glu Asp Met Val Gly Ser Cys 245 250 255 Page 1264 of 3790 Pro Phe Glu Pro Gly Gin Lys Arg Thr Ala Arg Arg Ala Pro Ser Phe 260 265 270 Glu Leu Phe Arg Phe Leu Ser Arg Leu Ala Asn Leu Lys Leu Thr Val 275 280 285 Gly Arg Ala Pro Glu Arg Arg Leu Thr Pro Asp Glu Ile Ala Leu Ala 290 295 300 Ala Lys Gly Phe Gly Glu Thr Lys Lys Ser Ile Thr Phe Lys Ser Leu 305 310 315 320 Arg Glu Ala Leu Asp Leu Asp Pro Asn Ala Arg Phe Ser Gly Val Ala 325 330 335 Lys Glu Lys Glu Ser Thr Leu Asp Val Ala Ala Arg Thr Gly Gly Ala 340 345 350 Ala Tyr Gly Thr Lys Thr Leu Lys Asp Ala Leu Gly Asp Ala Pro Trp 355 360 365 Arg Ser Leu Ser Arg Met Pro Glu Lys Leu Asp Arg Ile Ala Glu Ile 370 375 380 Leu Ser Phe Arg Glu Asp Met Lys Ala Ile Arg Asn Gly Leu Glu Glu 385 390 395 400 Val Gly Leu Asp Gly Leu Val Val Asp Ala Leu Met Gin Ala Thr Ala 405 410 415 Asn Gly Asp Phe Lys Asp Phe Thr Arg Ala Ala His Ile Ser Ala Leu 420 425 430 Ala Ala Arg Asn Ile Ile Pro Gly Leu Arg Glu Gly Leu Val Tyr Ser 435 440 445 Asp Ala Cys Thr Arg Val Gly Tyr Asp His Ala Ala Arg Pro Ala Val 450 455 460 Pro Leu Ser Gin Ile Gly Ser Pro Val Thr Arg Lys Ala Leu Ser Glu 465 470 475 480 Ala Leu Lys Gin Val Arg Ala Val Ala Arg Glu Tyr Gly Pro Ile Asp 485 490 495 Tyr Phe His Ile Glu Leu Ala Arg Ser Ile Gly Lys Ser Ala Glu Glu 725 730 735 Lys Arg Val Glu Asp Asp Arg His His Ala Val Asp Ala Leu Val Leu 740 745 750 Page 1266 of 3790 Page 1267 of 3790 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Page 1268 of 3790 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Page 1269 of 3790 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Page 1270 of 3790 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 910 Page 1271 of 3790 905 Page 1272 of 3790 Page 1273 of 3790 Ser Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys Lys Lys Arg 1385 1390 1395 Lys Val Asp 1400 257 1368 PRT Artificial Sequence Synthetic amino acid sequence 257 Page 1274 of 3790 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Page 1275 of 3790 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Page 1276 of 3790 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Val Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Gin Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 930 Page 1277 of 3790 935 940 Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 945 950 955 960 Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gin Phe Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 1010 1015 1020 Lys Ser Glu Gin Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe 1025 1030 1035 Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala 1040 1045 1050 Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 1055 1060 1065 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val 1070 1075 1080 Arg Lys Val Leu Ser Met Pro Gin Val Asn Ile Val Lys Lys Thr 1085 1090 1095 Glu Val Gin Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 1100 1105 1110 Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 1115 1120 1125 Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 1130 1135 1140 Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys 1145 1150 1155 Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 1160 1165 1170 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Page 1280 of 3790 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Page 1281 of 3790 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 1282 of 3790 Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 20 25 30 Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Page 1286 of 3790 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Page 1287 of 3790 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gin Ser Phe Leu Lys 835 840 845 Page 1288 of 3790 Arg Lys Val Leu Ser Met Pro Gin Val Asn Ile Val Lys Lys Thr 260 15 PRT Artificial Sequence Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn 20 25 263 8 PRT Artificial Seguence Page 1291 of 3790 Ile Asn Leu 15 Page 1292 of 3790 267 Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 15 10 15 Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 20 25 30 Ala Trp Lys Lys 15 Page 1293 of 3790 271 Tyr Ala Arg Ala Ala Ala Arg Gin Ala Arg Ala Artificial Seguence Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg Artificial Seguence Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 15 10 274 13 PRT Artificial Seguence Asp Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Artificial Seguence Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val 15 10 15 Page 1294 of 3790 Asp 276 4206 DNA Artificial Sequence Synthetic nucleic acid sequence 276 Page 1295 of 3790 Page 1296 of 3790 gactga 4206 277 1401 PRT Artificial Sequence Synthetic amino acid sequence 277 Page 1297 of 3790 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Page 1298 of 3790 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Page 1299 of 3790 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Leu Lys 835 840 845 Page 1300 of 3790 Page 1301 of 3790 Page 1302 of 3790 Lys Val Asp 1400 278 50 DNA Artificial Sequence Synthetic nucleic acid sequence 278 ttatatgaac ataactcaat ttgtaaaaaa gggtattggg gaattcatta 50 279 50 DNA Artificial Sequence Synthetic nucleic acid sequence 279 taatgaattc cccaataccc ttttttacaa attgagttat gttcatataa 50 280 42 RNA Artificial Sequence Synthetic nucleic acid sequence 280 auaacucaau uuguaaaaaa guuuuagagc uaugcuguuu ug 42 281 27 DNA Artificial Seguence Page 1303 of 3790 Synthetic nucleic acid sequence 281 aacataactc aatttgtaaa aaagggt 27 282 accctttttt acaaattgag ttatgtt 27 auaacucaau uuguaaaaaa guuuu 25 284 agcataactc aatttgtaaa aaa 23 285 aacataactc aatctgtaaa aaa 23 Page 1304 of 3790 286 aacataactc aatttgaaaa aaa 23 287 23 DNA Artificial Sequence Synthetic nucleic acid sequence 287 aacataactc aatttgttaa aaa 23 288 23 DNA Artificial Sequence Synthetic nucleic acid sequence 288 aacataactc aatttgtata aaa 23 289 23 DNA Artificial Sequence Synthetic nucleic acid sequence 289 aacataactc aatttgtaat aaa 23 290 23 DNA Artificial Sequence Synthetic nucleic acid sequence 290 aacataactc aatttgtaaa taa 23 291 27 DNA Artificial Sequence Synthetic nucleic acid sequence 291 aacataactc aatttgtaaa aaatggc Page 1305 of 3790 292 27 DNA Artificial Sequence Synthetic nucleic acid sequence 292 gccatttttt acaaattgag ttatgtt 27 293 20 DNA Artificial Sequence Synthetic nucleic acid sequence 293 tattgagtta aagtaaaaaa 20 294 20 DNA Artificial Sequence Synthetic nucleic acid sequence 294 tattgagtta ttgtaaaaaa 20 295 20 DNA Artificial Sequence Synthetic nucleic acid sequence 295 tattgagtat ttgtaaaaaa 20 296 20 DNA Artificial Sequence Synthetic nucleic acid sequence 296 tattgacaat ttgtaaaaaa 20 297 20 Page 1306 of 3790 DNA Artificial Sequence Synthetic nucleic acid sequence 297 tattctcaat ttgtaaaaaa 20 298 20 DNA Artificial Sequence Synthetic nucleic acid sequence 298 taaactcaat ttgtaaaaaa 20 299 62 RNA Artificial Sequence Synthetic nucleic acid sequence 299 aaaaauuagg ugcgcuuggc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cg 62 300 54 RNA Artificial Sequence Synthetic nucleic acid sequence 300 aaaaauuagg ugcgcuuggc guuuuagagc uagaaauagc aaguuaaaau aagg 54 301 50 DNA Artificial Sequence Synthetic nucleic acid sequence 301 tgcgctggtt gatttcttct tgcgcttttt gggtattggg gaattcatta 50 302 50 DNA Page 1307 of 3790 Artificial Sequence Synthetic nucleic acid sequence 302 taatgaattc cccaataccc aaaaagcgca agaagaaatc aaccagcgca 50 303 42 RNA Artificial Sequence Synthetic nucleic acid sequence 303 gauuucuucu ugcgcuuuuu guuuuagagc uaugcuguuu ug 42 304 50 DNA Artificial Sequence Synthetic nucleic acid sequence 304 ggttatatta agtgccgagg aaaaattagg tgcgcttggc tggcgcatta 50 305 50 DNA Artificial Sequence Synthetic nucleic acid sequence 305 taatgcgcca gccaagcgca cctaattttt cctcggcact taatataacc 50 306 42 RNA Artificial Sequence Synthetic nucleic acid sequence 306 aaaaauuagg ugcgcuuggc guuuuagagc uaugcuguuu ug 42 307 50 DNA Artificial Seguence Page 1308 of 3790 Synthetic nucleic acid sequence 307 tacgctggtt gatttcttct tgcgcttttt tggctttttc gagttcggct 50 308 50 DNA Artificial Sequence Synthetic nucleic acid sequence 308 agccgaactc gaaaaagcca aaaaagcgca agaagaaatc aaccagcgta 50 309 42 RNA Artificial Sequence Synthetic nucleic acid sequence 309 gauuucuucu ugcgcuuuuu guuuuagagc uaugcuguuu ug 42 310 14 DNA Artificial Sequence Synthetic nucleic acid sequence 310 taatgcgcca gcca 14 311 42 RNA Artificial Sequence Synthetic nucleic acid sequence 311 aaaaauuagg ugcgcuuggc guuuuagagc uaugcuguuu ug 42 Page 1309 of 3790 ataactcaat ttgtaaaaaa gggta 25 313 25 DNA Artificial Sequence Synthetic nucleic acid sequence 313 ataactcaat ttgtaaaaaa gcgta 25 314 25 DNA Artificial Sequence Synthetic nucleic acid sequence 314 ataactcaat ttgtaaaaaa gccta 25 315 26 DNA Artificial Sequence Synthetic nucleic acid sequence 315 aaaaattagg tgcgcttggc tggcgc 26 316 26 DNA Artificial Sequence Synthetic nucleic acid sequence 316 aaaaattagg tgcgcttggc tcgcgc 26 317 26 DNA Artificial Sequence Synthetic nucleic acid sequence 317 aaaaattagg tgcgcttggc tgccgc 26 Page 1310 of 3790 318 aaaaattagg tgcgcttggc tggccc 26 319 aaaaattagg tgcgcttggc tccccc 26 320 aaaaattagg tgcgcttggc t 21 gauuucuucu ugcgcuuuuu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cg 62 gauuucuucu ugcgcuuuuu guuuuagagc uagaaauagc aaguuaaaau aagg 54 323 Page 1311 of 3790 62 RNA Artificial Seguence Synthetic nucleic acid seguence 323 auaacucaau uuguaaaaaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cg 324 54 RNA Artificial Seguence Synthetic nucleic acid seguence 324 auaacucaau uuguaaaaaa guuuuagagc uagaaauagc aaguuaaaau aagg 325 120 DNA Artificial Seguence Synthetic nucleic acid seguence 325 gtcccaattc ttgttgaatt agatggtgat gttaatgggc acaaattttc tgtcagtgga gagggtgaag gtgatgcaac atacggaaaa cttaccctta aatttatttg cactactgga 326 120 DNA Artificial Seguence Synthetic nucleic acid seguence 326 tccagtagtg caaataaatt taagggtaag ttttccgtat gttgcatcac cttcaccctc tccactgaca gaaaatttgt gcccattaac atcaccatct aattcaacaa gaattgggac 120 120 327 26 DNA Artificial Seguence Synthetic nucleic acid seguence 327 ccaattcttg ttgaattaga tggtga Page 1312 of 3790 328 aattagatgg tgatgttaat gggcac 26 329 aaattttctg tcagtggaga gggtga 26 330 catctaattc aacaagaatt gggaca 26 331 cagtagtgca aataaattta agggta 26 ccaauucuug uugaauuaga uggugaguuu uagagcuaga aauagcaagu uaaaauaagg 60 cuaguccg Page 1313 of 3790 333 68 RNA Artificial Seguence Synthetic nucleic acid seguence 333 aauuagaugg ugauguuaau gggcacguuu uagagcuaga aauagcaagu uaaaauaagg cuaguccg 334 68 RNA Artificial Seguence Synthetic nucleic acid seguence 334 aaauuuucug ucaguggaga gggugaguuu uagagcuaga aauagcaagu uaaaauaagg cuaguccg 335 68 RNA Artificial Seguence Synthetic nucleic acid seguence 335 caucuaauuc aacaagaauu gggacaguuu uagagcuaga aauagcaagu uaaaauaagg cuaguccg 336 68 RNA Artificial Seguence Synthetic nucleic acid seguence 336 caguagugca aauaaauuua aggguaguuu uagagcuaga aauagcaagu uaaaauaagg cuaguccg 337 50 DNA Artificial Seguence Page 1314 of 3790 Synthetic nucleic acid sequence 337 ggttatatta agtgccgagg aaaaattagg tgcgcttggc tgccgcatta 50 338 50 DNA Artificial Sequence Synthetic nucleic acid sequence 338 taatgcggca gccaagcgca cctaattttt cctcggcact taatataacc 50 339 42 RNA Artificial Sequence Synthetic nucleic acid sequence 339 aaaaauuagg ugcgcuuggc guuuuagagc uaugcuguuu ug 42 340 59 DNA Artificial Sequence Synthetic nucleic acid sequence 340 gaaattaata cgactcacta tagaaaacag catagcaagt taaaataaag ttaaaataa 59 341 25 DNA Artificial Sequence Synthetic nucleic acid sequence 341 aaaaaaagca ccgactcggt gccac 25 Page 1315 of 3790 gaaattaata cgactcacta tagggatttc ttcttgcgct ttttgtttta gagctatgct gttttg 343 66 DNA Artificial Sequence Synthetic nucleic acid sequence 343 caaaacagca tagctctaaa acaaaaagcg caagaagaaa tccctatagt gagtcgtatt 60 aatttc 66 344 66 DNA Artificial Sequence Synthetic nucleic acid sequence 344 gaaattaata cgactcacta taggataact caatttgtaa aaaagtttta gagctatgct 60 gttttg 66 345 66 DNA Artificial Sequence Synthetic nucleic acid sequence 345 caaaacagca tagctctaaa acttttttac aaattgagtt atcctatagt gagtcgtatt 60 aatttc 66 346 51 DNA Artificial Sequence Synthetic nucleic acid sequence 346 gaaattaata cgactcacta tagatgatga gaaccgttgc tacaataagg c 51 347 24 DNA Artificial Seguence Page 1316 of 3790 Synthetic nucleic acid sequence 347 aaataaacga tgccccttaa agca 348 68 DNA Artificial Sequence Synthetic nucleic acid sequence 348 gaaattaata cgactcacta tagatgataa ctcaatttgt aaaaaagttg tagctccctt tctcattt 349 68 DNA Artificial Sequence Synthetic nucleic acid sequence 349 aaatgagaaa gggagctaca acttttttac aaattgagtt atcatctata gtgagtcgta ttaatttc 350 51 DNA Artificial Sequence Synthetic nucleic acid sequence 350 gaaattaata cgactcacta tagatgaaat aacatagcaa gttaaaataa g 351 31 DNA Artificial Sequence Synthetic nucleic acid sequence 351 aaaaaaagcg ccgaaacagc gctacttaat t 31 352 68 DNA Page 1317 of 3790 Artificial Sequence Synthetic nucleic acid sequence 352 gaaattaata cgactcacta tagatgataa ctcaatttgt aaaaaagttt tagagctatg ttattttg 353 68 DNA Artificial Sequence Synthetic nucleic acid sequence 353 caaaataaca tagctctaaa acttttttac aaattgagtt atcatctata gtgagtcgta 60 ttaatttc 354 35 DNA Artificial Sequence Synthetic nucleic acid sequence 354 atgcacctgc aggatgctgt taaataattg tatac 35 355 36 DNA Artificial Sequence Synthetic nucleic acid sequence 355 atgcacggat ccagctgctc taagtctact aaaacc 36 356 39 DNA Artificial Sequence Synthetic nucleic acid sequence 356 atgcagggcc ggccgtgaca gagagaaact tgattcaac 39 357 39 Page 1318 of 3790 DNA Artificial Sequence Synthetic nucleic acid sequence 357 atgcagggcc ggcccttcgt ttaagtaaac atcaaagtg 39 358 59 DNA Artificial Sequence Synthetic nucleic acid sequence 358 atgagcgata atagaataaa gttatatgag cataactcaa tttgtaaaaa agggtattg 59 359 59 DNA Artificial Sequence Synthetic nucleic acid sequence 359 caataccctt ttttacaaat tgagttatgc tcatataact ttattctatt atcgctcat 59 360 57 DNA Artificial Sequence Synthetic nucleic acid sequence 360 gcgataatag aataaagtta tatgaacata actcaatctg taaaaaaggg tattggg 57 361 57 DNA Artificial Sequence Synthetic nucleic acid sequence 361 cccaataccc ttttttacag attgagttat gttcatataa ctttattcta ttatcgc 57 362 40 DNA Artificial Seguence Page 1319 of 3790 Synthetic nucleic acid sequence 362 gaacataact caatttgaaa aaaagggtat tggggaattc 40 363 40 DNA Artificial Sequence Synthetic nucleic acid sequence 363 gaattcccca ataccctttt tttcaaattg agttatgttc 40 364 40 DNA Artificial Sequence Synthetic nucleic acid sequence 364 gaacataact caatttgtta aaaagggtat tggggaattc 40 365 40 DNA Artificial Sequence Synthetic nucleic acid sequence 365 gaattcccca ataccctttt taacaaattg agttatgttc 40 366 43 DNA Artificial Sequence Synthetic nucleic acid sequence 366 gaacataact caatttgtat aaaagggtat tggggaattc att 43 Page 1320 of 3790 367 aatgaattcc ccaataccct tttatacaaa ttgagttatg ttc 43 368 43 DNA Artificial Sequence Synthetic nucleic acid sequence 368 gaacataact caatttgtaa taaagggtat tggggaattc att 43 369 43 DNA Artificial Sequence Synthetic nucleic acid sequence 369 aatgaattcc ccaataccct ttattacaaa ttgagttatg ttc 43 370 40 DNA Artificial Sequence Synthetic nucleic acid sequence 370 cataactcaa tttgtaaata agggtattgg ggaattcatt 40 371 40 DNA Artificial Sequence Synthetic nucleic acid sequence 371 aatgaattcc ccaataccct tatttacaaa ttgagttatg 40 372 46 DNA Artificial Sequence Synthetic nucleic acid sequence 372 cataactcaa tttgtaaaaa agcgtattgg ggaattcatt ataaag Page 1321 of 3790 373 46 DNA Artificial Sequence Synthetic nucleic acid sequence 373 ctttataatg aattccccaa tacgcttttt tacaaattga gttatg 46 374 44 DNA Artificial Sequence Synthetic nucleic acid sequence 374 cataactcaa tttgtaaaaa agcctattgg ggaattcatt ataa 44 375 44 DNA Artificial Sequence Synthetic nucleic acid sequence 375 ttataatgaa ttccccaata ggctttttta caaattgagt tatg 44 376 38 DNA Artificial Sequence Synthetic nucleic acid sequence 376 atgcagggcc ggccagtatc agcgtacttg gatttggg 38 377 37 DNA Artificial Sequence Synthetic nucleic acid sequence 377 atgcagggcc ggccttgtct cactcactct atttttg 37 378 30 Page 1322 of 3790 DNA Artificial Sequence Synthetic nucleic acid sequence 378 gatttcttgc gcttttttgg ctttttcgag 30 379 30 DNA Artificial Sequence Synthetic nucleic acid sequence 379 gggatggcaa tccatgggtc aaggtactag 30 380 20 DNA Artificial Sequence Synthetic nucleic acid sequence 380 ggaacgaaaa ctcacgttaa 20 381 25 DNA Artificial Sequence Synthetic nucleic acid sequence 381 tgagagtgtc ttttcagatg ctgtg 25 382 21 DNA Artificial Sequence Synthetic nucleic acid sequence 382 agcggtatct gttccccaaa a 21 383 21 DNA Artificial Seguence Page 1323 of 3790 Synthetic nucleic acid sequence 383 gttaaaaacc acgtaaccac a 21 384 42 RNA Artificial Sequence Synthetic nucleic acid sequence 384 gauuucuucu ugcgcuuuuu guuuuagagc uaugcuguuu ug 42 385 42 RNA Artificial Sequence Synthetic nucleic acid sequence 385 auaacucaau uuguaaaaaa guuuuagagc uaugcuguuu ug 42 386 42 RNA Artificial Sequence Synthetic nucleic acid sequence 386 aaaaauuagg ugcgcuuggc guuuuagagc uaugcuguuu ug 42 387 36 RNA Artificial Sequence Synthetic nucleic acid sequence 387 auaacucaau uuguaaaaaa guuuuagagc uaugcu 36 Page 1324 of 3790 388 auaacucaau uuguaaaaaa guuuuagagc ua 32 389 22 RNA Artificial Sequence Synthetic nucleic acid sequence 389 uuguaaaaaa guuuuagagc ua 22 390 89 RNA Artificial Sequence Synthetic nucleic acid sequence 390 guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga 60 aaaaguggca ccgagucggu gcuuuuuuu 89 391 74 RNA Artificial Sequence Synthetic nucleic acid sequence 391 aacagcauag caaguuaaaa uaaggcuagu ccguuaucaa cuugaaaaag uggcaccgag 60 ucggugcuuu uuuu 74 392 67 RNA Artificial Sequence Synthetic nucleic acid sequence 392 uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc gagucggugc 60 uuuuuuu 393 39 RNA Artificial Seguence Page 1325 of 3790 aaacagcaua gcaaguuaaa auaaggcuag uccguuauc 39 aaacagcaua gcaaguuaaa auaaggcuag 30 aaacagcaua gcaaguuaaa au 22 uagcaaguua aaauaaggcu aguccguuau c 31 uagcaaguua aaauaaggcu aguccg 26 Page 1326 of 3790 398 uagcaaguua aaauaaggcu ag 22 guuggaacca uucaaaacag cauagc 26 gauuucuucu ugcgcuuuuu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cg 62 gauuucuucu ugcgcuuuuu guuuuagagc uagaaauagc aaguuaaaau aagg 54 auaacucaau uuguaaaaaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 Page 1327 of 3790 403 auaacucaau uuguaaaaaa guuuuagagc uagaaauagc aaguuaaaau aagg 54 404 62 RNA Artificial Sequence Synthetic nucleic acid sequence 404 aaaaauuagg ugcgcuuggc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cg 62 405 54 RNA Artificial Sequence Synthetic nucleic acid sequence 405 aaaaauuagg ugcgcuuggc guuuuagagc uagaaauagc aaguuaaaau aagg 54 406 62 RNA Artificial Sequence Synthetic nucleic acid sequence 406 ccaauucuug uugaauuaga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cg 62 407 62 RNA Artificial Sequence Synthetic nucleic acid sequence 407 aauuagaugg ugauguuaau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc 60 cg 408 62 RNA Artificial Seguence Page 1328 of 3790 Synthetic nucleic acid seguence 408 aaauuuucug ucaguggaga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cg 409 62 RNA Artificial Seguence Synthetic nucleic acid seguence 409 caucuaauuc aacaagaauu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cg 410 61 RNA Artificial Seguence Synthetic nucleic acid seguence 410 caguagugca aauaaauuua guuuuagagc uagaaauagc aaguuaaaau aaggcuagcc g 411 50 DNA Artificial Seguence Synthetic nucleic acid seguence 411 taatgaattc cccaataccc aaaaagcgca agaagaaatc aaccagcgca 412 50 DNA Artificial Seguence Synthetic nucleic acid seguence 412 tgcgctggtt gatttcttct tgcgcttttt gggtattggg gaattcatta 413 Page 1329 of 3790 50 DNA Artificial Sequence Synthetic nucleic acid sequence 413 taatgaattc cccaataccc ttttttacaa attgagttat gttcatataa 414 50 DNA Artificial Sequence Synthetic nucleic acid sequence 414 ttatatgaac ataactcaat ttgtaaaaaa gggtattggg gaattcatta 415 50 DNA Artificial Sequence Synthetic nucleic acid sequence 415 taatgcgcca gccaagcgca cctaattttt cctcggcact taatataacc 416 50 DNA Artificial Sequence Synthetic nucleic acid sequence 416 ggttatatta agtgccgagg aaaaattagg tgcgcttggc tggcgcatta 417 50 DNA Artificial Sequence Synthetic nucleic acid sequence 417 taatgaattc cccaataggc ttttttacaa attgagttat gttcatataa 418 50 DNA Artificial Seguence Page 1330 of 3790 Synthetic nucleic acid sequence 418 ttatatgaac ataactcaat ttgtaaaaaa gcctattggg gaattcatta 50 419 50 DNA Artificial Sequence Synthetic nucleic acid sequence 419 taatgaattc ccgttatggc ttttttacaa attgagttat gttcatataa 50 420 50 DNA Artificial Sequence Synthetic nucleic acid sequence 420 ttatatgaac ataactcaat ttgtaaaaaa gccataacgg gaattcatta 50 421 50 DNA Artificial Sequence Synthetic nucleic acid sequence 421 taatgcgcga gccaagcgca cctaattttt cctcggcact taatataacc 50 422 50 DNA Artificial Sequence Synthetic nucleic acid sequence 422 ggttatatta agtgccgagg aaaaattagg tgcgcttggc tcgcgcatta 50 Page 1331 of 3790 423 taatgcggca gccaagcgca cctaattttt cctcggcact taatataacc 50 424 50 DNA Artificial Sequence Synthetic nucleic acid sequence 424 ggttatatta agtgccgagg aaaaattagg tgcgcttggc tgccgcatta 50 425 74 DNA Artificial Sequence Synthetic nucleic acid sequence 425 tcagtcctca tctccctcaa gcaggccccg ctggtgcact gaagagccac cctgtggaaa 60 cactacatct gcaa 74 426 74 DNA Artificial Sequence Synthetic nucleic acid sequence 426 ttgcagatgt agtgtttcca cagggtggct cttcagtgca ccagcggggc ctgcttgagg 60 gagatgagga ctga 74 427 20 DNA Artificial Sequence Synthetic nucleic acid sequence 427 tgtggaaaca ctacatctgc 20 428 62 RNA Artificial Seguence Page 1332 of 3790 Synthetic nucleic acid seguence 428 gcagauguag uguuuccaca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cg 429 75 RNA Artificial Seguence Synthetic nucleic acid seguence 429 gcagauguag uguuuccaca guuuuagagc uaugcugaaa agcauagcaa guuaaaauaa ggcuaguccg uuauc 430 87 RNA Artificial Seguence Synthetic nucleic acid seguence 430 gcagauguag uguuuccaca guuuuagagc uaugcuguuu uggaaacaaa acagcauagc aaguuaaaau aaggcuaguc cguuauc 431 86 RNA Artificial Seguence Synthetic nucleic acid seguence 431 ggaaccauuc aaaacagcau agcaaguuaa aauaaggcua guccguuauc aacuugaaaa aguggcaccg agucggugcu uuuuuu 432 67 RNA Artificial Seguence Synthetic nucleic acid seguence 432 uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc gagucggugc uuuuuuu Page 1333 of 3790 433 88 RNA S. pyogenes 433 guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu gcuuuuuu 434 93 RNA L. innocua 434 auauuguuag uauucaaaau aacauagcaa guuaaaauaa ggcuuugucc guuaucaacu uuuaauuaag uagcgcuguu ucggcgcuuu uuu 435 104 RNA S. mutans 435 uguuggaauc auucgaaaca acacagcaag uuaaaauaag gcagugauuu uuaauccagu ccguacacaa cuugaaaaag ugcgcaccga uucggugcuu uuuu 436 95 RNA S. thermophilus 436 uugugguuug aaaccauucg aaacaacaca gcgaguuaaa auaaggcuua guccguacuc aacuugaaaa gguggcaccg auucgguguu uuuuu 437 118 RNA S. thermophilus 437 uaauaauagu guaagggacg ccuuacacag uuacuuaaau cuugcagaag cuacaaagau aaggcuucau gccgaaauca acacccuguc auuuuauggc aggguguuuu cguuauuu 104 118 438 112 RNA Neisseria meningitidis 438 cauauugucg cacugcgaaa ugagaaccgu ugcuacaaua aggccgucug aaaagaugug Page 1334 of 3790 ccgcaacgcu cugccccuua aagcuucugc uuuaaggggc aucguuuauu uc 112 439 110 RNA Pasteurella multocida 439 gcauauuguu gcacugcgaa augagagacg uugcuacaau aaggcuucug aaaagaauga 60 ccguaacgcu cugccccuug ugauucuuaa uugcaagggg caucguuuuu 110 Page 1335 of 3790 cuuacacagu uacuuaaauc uugcagaagc uacaaa 36 auauuguuag uauucaaaau aacauagcaa guuaaa 36 auuguuagua uucaaaauaa cauagcaagu uaaa 34 auuuaagauc caucuuaaau uacacaacga guucaa 36 auugucgcac ugcgaaauga gaaccguugc uacaau 36 auauugucgc acugcgaaau gagaaccguu gcuacaau 38 cuuacacagu uacuuaaauc uugcagaagc uacaaa 36 Page 1336 of 3790 augaucaagg ucauugaccu gacaggcaua aauuga 36 gguuuugacc ucauugauuu aacauucuga guugaa 36 guuucaguug uuagauuauu ugguauguac uuguguu 37 auuacagagc auuaauuauu ugguacauuu auaauuu 37 auuucagggu aucgaaauuu agaugauuuc uaauuua 37 uguaacaggg uaggguuuuu ugaggggucu uaaaau 36 aguuucuaau cacuuaauuu uuucggaccu acuaaa 36 Page 1337 of 3790 gauucacauu auucaaguuu acuacagauu cuguau 36 aguuaagaau acauaagaau gauacaucac uaaaaa 36 auugugaauu gcuuucaaau ugugcgacaa aaguagguau aaua 44 auugcagcaa cggcucucac cccggauaac cacaau 36 auagccgcug ccuacucagc cauuuagcgc agcgac 36 uuuguuaaag cuggauggga uuauuauaga guguugc 37 uuucaaggca ucgaacggau uugcuauaaa guguugc 37 Page 1338 of 3790 uuuugcacac guaagauucc uacaucuuau cacaau 36 auugugaauu gcuuucagau uaugaaaaua auauaguuaa aauuuuug 48 auuuuauuuc gauuuuaauc aacccuaaau uucaau 36 auuuuagucc cuuuuuaaau uucuuaugag auuaua 36 aagaaauuua aaaagggacu aaaau 25 auuguagcaa cgucucucau uucgcagugc aacaau 36 gccguggcuu uccuaccgau uucccaccgc augauu 36 Page 1339 of 3790 ucugaauuac cagucagaac gauacugcga gucaaa 36 guuccauggc cccgucccac acgccaugau agagcg 36 aaacgggaga accgucccac acggccaugg uagagu 36 uuaacggcuc gaccgcgaau ucugaacgua aagaca 36 uuagcgucca gagcgcauau cccagugaga uauccg 36 aaacagcaua gcaaguuaaa auaaggcuag uccguuauca acuugaaaaa guggcaccga 60 gucggugcuu uuuuu 75 Page 1340 of 3790 ucggugcuuu uuu 73 481 33 RNA Francisella novicida 481 uauaaaugua ccaaauaauu aaugcucugu aau 33 482 74 RNA Campylobacter jejuni 482 aagaaauuua aaaagggacu aaaauaaaga guuugcggga cucugcgggg uuacaauccc 60 cuaaaaccgc uuuu 7 4 483 96 RNA Francisella novicida 483 aucuaaaauu auaaauguac caaauaauua augcucugua aucauuuaaa aguauuuuga 60 acggaccucu guuugacacg ucugaauaac uaaaaa 96 484 109 RNA Streptococcus thermophilus2 484 uguaagggac gccuuacaca guuacuuaaa ucuugcagaa gcuacaaaga uaaggcuuca ugccgaaauc aacacccugu cauuuuaugg caggguguuu ucguuauuu 109 485 Page 1341 of 3790 110 RNA Mycoplasma mobile 485 uguauuucga aauacagaug uacaguuaag aauacauaag aaugauacau cacuaaaaaa aggcuuuaug ccguaacuac uacuuauuuu caaaauaagu aguuuuuuuu 486 92 RNA Listeria innocua 486 auuguuagua uucaaaauaa cauagcaagu uaaaauaagg cuuuguccgu uaucaacuuu uaauuaagua gcgcuguuuc ggcgcuuuuu uu 487 89 RNA Streptococcus pyogenes 487 guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu gcuuuuuuu 488 107 RNA Streptococcus mutans 488 guuggaauca uucgaaacaa cacagcaagu uaaaauaagg cagugauuuu uaauccaguc cguacacaac uugaaaaagu gcgcaccgau ucggugcuuu uuuauuu 489 96 RNA Streptococcus thermophilus 489 uugugguuug aaaccauucg aaacaacaca gcgaguuaaa auaaggcuua guccguacuc aacuugaaaa gguggcaccg auucgguguu uuuuuu 490 102 RNA Neisseria meningitidis 490 acauauuguc gcacugcgaa augagaaccg uugcuacaau aaggccgucu gaaaagaugu gccgcaacgc ucugccccuu aaagcuucug cuuuaagggg ca 110 107 102 Page 1342 of 3790 gcauauuguu gcacugcgaa augagagacg uugcuacaau aaggcuucug aaaagaauga 60 ccguaacgcu cugccccuug ugauucuuaa uugcaagggg caucguuuuu 110 aacacaagua cauaccaaau aaucuaacaa cugaaac 37 aaauuauaaa uguaccaaau aauuaaugcu cuguaau 37 uuucaaggca ucgaacggau uugcuauaaa guguugc 37 uuuguuaaag cuggauggga uuauuauaga guguugc 37 auuucagugu auagaauguu gggaugcauu cugaaua 37 Page 1343 of 3790 497 auaacaaggg aguauuugcu ggaauaagcu cugaaac 37 guuuccaagc aauagcucgu ggcguuauga uuucugu 37 ggugauuucc uauagcucau agcguuauga ucucuaa 37 auuucagggu aucgaaauuu agaugauuuc uaauuua 37 auauuguuag uauucaaaau aacauagcaa guuaaa 36 gguuugaaac cauucgaaac aacacagcga guuaaa 36 guguuggaau cauucgaaac aacacagcaa guuaaa 36 Page 1344 of 3790 504 uuguuggaac cauucaaaac agcauagcaa guuaaa 36 auuuuuaauu uaaguaauaa aaaauggagc auauac 36 aguugacuac cauaugagau uacacuacac gguuca 36 auuuaagauc caucuuaaau uacacaacga guucaa 36 cuuauaccag uaagauaauu uacauaguaa guucaa 36 guuuuggagg uuuacagaau uacacuacga guucaa 36 guuuaauacc uauaugagau uacaucauga guucaa 36 Page 1345 of 3790 511 ucugaauuac cagucagaac gauacugcga gucaaa 36 caacuugaau ugauugaucu gacaucuacg aguuga 36 ugauuagauu ucauugaucu aacagccauc uaaaac 36 acacuaaacu uuauugaucu aacaaccaga uuuaaa 36 ggguucuacc ucauugaucu gacacacagc auugaa 36 augaucaagg ucauugaccu gacaggcaua aauuga 36 guuuuacuuc uuucuaaaua aacauaguua aguuaa 36 Page 1346 of 3790 518 auuuuauagu cacguaaauu uuucagaucu acuaaa 36 auuuuacuga uaagaaauua uugagaaucu acaaaaau 38 cuuacacagu uacuuaaauc uugcagaagc uacaaa 36 cuuguacuua uaccuaaaau uacagaaucu acugaa 36 aucauaaucu agcaaaaguu uauaugaucu aacaaa 36 aguuaagaau acauaagaau gauacaucac uaaaaa 36 auuuuacucu aguaagaaau ugucgcacaa aaauaa 36 Page 1347 of 3790 525 auuauugcuu acacaauuau ugucgugcua aaauaa 36 auuauuguuu acccaaauau uguacauccu aaauca 36 uacuuacuua acaaaauaau uguacgauuc caaaau 36 gccuucccuc ccugccgaag gagcagaucc ucuccu 36 uuauaguaac uaguuaaacu cucgauaugc uauacc 36 auuauagcaa caauucaggc uccgauaugc cauaau 36 auugcagcaa cggcucucac cccggauaac cacaau 36 Page 1348 of 3790 532 auugucgcac ugcgaaauga gaaccguugc uacaau 36 auuguugcac ugcgaaauga gagacguugc uacaau 36 uuuguaacuu aucugagaga ggaugguuau uauaau 36 auagccgcug ccuacucagc cauuuagcgc agcgac 36 auaauacaaa aaucauuuuu uuaaacaaac auaaac 36 uauaaucuca uaagaaauuu aaaaagggac uaaaau 36 guauuuguca auaaauauac uuuauaaugg caagau 36 Page 1349 of 3790 539 uuguaauaac cuaauuauca cuugguauga uauaau 36 uuuuauucua uaguaaguuu ucagcuaaaa uagauc 36 gccguggcuu uccuaccgau uucccaccgc augauu 36 uaaccauagg cuccucaauc accagagugu uauugc 36 uuagcgucca gagcgcauau cccagugaga uauccg 36 guuaguagca aagcgcaauu cccgaucugc uggaaa 36 uuaacggcug gacccccgau ccccaucgaa uuucca 36 Page 1350 of 3790 546 uuaacggcuc gaccgcgaau ucugaacgua aagaca 36 guuccauggc cccgucccac acgccaugau agagcg 36 aaacgggaga accgucccac acggccaugg uagagu 36 auuagagaua aucgcugguu uuuguuaaga uauaac 36 uuuugcacac guaagauucc uacaucuuau cacaau 36 agauaaaauu auucuaaucu uuaaucuuau cacaau 36 cuugcgaaaa gcgaccgccu cucgauuugc uacaga 36 Page 1351 of 3790 553 auugugaauu gcuuucaaau ugugcgacaa aaguagguau aaua 44 554 48 RNA Fibrobacter succinogenes 554 auugugaauu gcuuucagau uaugaaaaua auauaguuaa aauuuuug 48 555 36 RNA Nitratifractor salsuginis 555 uguaacaggg uaggguuuuu ugaggggucu uaaaau 36 556 36 RNA Akkermansia muciniphila 556 cuuauacggg aacuccacga uaaggcauuu uacaug 36 557 88 RNA Artificial Sequence Synthetic nucleic acid sequence 557 uuggaaccau ucaaaacagc auagcaaguu aaaauaaggc uaguccguua ucaacuugaa 60 aaaguggcac cgagucggug cuuuuuuu 88 558 77 RNA Artificial Sequence Synthetic nucleic acid sequence 558 caaaacagca uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc 60 gagucggugc uuuuuuu 77 559 61 RNA Artificial Seguence Page 1352 of 3790 Synthetic nucleic acid seąuence 559 caaaacagca uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguuuuuuu 60 u 61 560 44 RNA Artificial Sequence Synthetic nucleic acid sequence 560 caaaacagca uagcaaguua aaauaaggcu aguccguuuu uuuu 44 561 72 RNA Artificial Sequence Synthetic nucleic acid sequence 561 caaaacagca uagcaaguua aaauaaggcu aguccgguuc acugccguau aggcagcuaa 60 gaaauuuuuu uu 72 562 14 RNA Artificial Sequence Synthetic nucleic acid sequence 562 uagcaaguua aaau 14 563 102 RNA Artificial Sequence Synthetic nucleic acid seguence misc_feature (1)..(80) n at each of these positions can be present or absent such that this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u Page 1353 of 3790 563 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60 nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu ug 102 564 102 RNA Artificial Sequence Synthetic nucleic acid seguence misc_feature (1)..(80) n at each of these positions can be present or absent such that this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u 564 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60 nnnnnnnnnn nnnnnnnnnn guuuuagagc uauguuauuu ug 102 565 92 RNA exemplary misc_feature (1)..(80) n at each of these positions can be present or absent such that this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u 565 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 60 nnnnnnnnnn nnnnnnnnnn guuuuagagc ua 92 566 152 RNA Artificial Seguence Synthetic nucleic acid seguence misc_feature (37)..(116) n at each of these positions can be present or absent such that this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u Page 1354 of 3790 566 guuuuagagc nnnnnnnnnn uagagcuaug uaugcuguuu nnnnnnnnnn cuguuuugaa ugaauggucc nnnnnnnnnn uggucccaaa caaaacnnnn nnnnnnnnnn ac nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnguuu 120 152 567 188 RNA Artificial Seguence Synthetic nucleic acid seguence misc_feature (37)..(116) n at each of these positions can be present or absent such that this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u 568 22 RNA exemplary 568 guuuuagagc uaugcuguuu ug 22 569 36 RNA Streptococcus pyogenes 569 guuuuagagc uaugcuguuu ugaauggucc caaaac 36 570 36 RNA Pasteurella multocida 570 guuguaguuc ccucucucau uucgcagugc uacaau 36 571 Page 1355 of 3790 guuuuggugu aguaucauuc uuauguauuc uuaaac 36 guuucaguug cugaauuauu ugguaaacua cuguuag 37 guuucaguug cugaauuauu ugguaaacua cug 33 guuuuagagc uguguuguuu cgaaugguuc caaaac 36 guuuuagagc uguguuguuu cgaaugguuc caaaac 36 guuuuuguac ucucaagauu uaaguaacug uacaac 36 guuuuagagc uauguuauuu ugaaugcuaa caaaac 36 578 Page 1356 of 3790 guuugagagu uguguaauuu aagauggauc ucaaac 36 guuguagcuc ccuuucucau uucgcagugc uacaau 36 guuuuuguac ucucaagauu uaaguaacug uacaac 36 guuucaaugc cugucagauc aaugacuuug accac 35 guuucagaag uauguuaaau caauaagguu aagacc 36 cuaacaguag uuuaccaaau aauucagcaa cugaaac 37 cuaacaguag uuuaccaaau aauucagcaa cugaaac 37 585 Page 1357 of 3790 ccaauaaucc cucaucuaaa aauccaacca cugaaac 37 guuuuaagac cccucaaaac cccacccugu uacaau 36 guuuuaguac ccgggaaaau uaagugauug gaaaac 36 gauacagauu cuugguaaau uugaauaaug ugaaug 36 guuuuggugu aguaucauuc uuauguauuc uuaaac 36 uguuaucaau cgcaaaacua caaaauuuga aagcaauuca caac 44 aguguagcua uccgggguga gagagggagc uacaac 36 592 Page 1358 of 3790 auuauagcga ggaauggcug aguaggcggc uauaac 36 gcaacacuuu auagcaaauc cgcuuagccu gugaaac 37 gcaacacuuu auagcaaauc cgcuuagccu gugaaac 37 guugugguuu gauguaggaa aggaaugaua uacaac 36 guuguuauug cacuaguaaa acuagaaaau cugaaagcaa uucacaac 48 auuuuaccau aaagaaauuu aaaaagggac uaaaac 36 guuuuagucc cuuuuuaaau uucuuuaugg uaaaau 36 599 Page 1359 of 3790 auuguagcac ugcgaaauga gagagggaac uacaac 36 agccuaccac ggggaaaucg guagggaagc cacggc 36 guuuuggggc agugucguuu ugacugguaa ucaaac 36 acucuaccau ggcggugugg gacggggcca uggaac 36 acucuaccau ggcggugugg gacggggcca uggaac 36 aguuuagcug uucagaauuc gggguccagc cgcaac 36 auuguagcuc acugggauau gcgcacuggc cggaac 36 606 Page 1360 of 3790 guuucaguug cugaauuauu ugguaaacua cuguuag 37 guuucaguug cugaauuauu ugguaaacua cuguuag 37 gcaacacuuu auagcaaauc cgcuuagccu gugaaac 37 gcaacacuuu auagcaaauc cgcuuagccu gugaaac 37 guuucagagc uuaucccaac aaaccaacag cugaaac 37 guuucagagc uuaucccaac aaaccaacag cugaaac 37 gcgaagauca uaacgcuacg agcuauagca cugaaac 37 613 Page 1361 of 3790 gcgaagauca uaacgcuacg agcuauagca cugaaac 37 ccaauaaucc cucaucuaaa aauccaacca cugaaac 37 guuuuagagc uauguuauuu ugaaugcuaa caaaac 36 guuuuagagc uguguuguuu cgaaugguuc caaaac 36 guuuuagagc uguguuguuu cgaaugguuc caaaac 36 guuuuagagc uaugcuguuu ugaauggucc caaaac 36 guuugagagu aauguuauuu uaaauagauu caaaac 36 620 Page 1362 of 3790 guuugagagu aguguaauuu cauaugguag ucaaac 36 guuugagagu uguguaauuu aagauggauc ucaaac 36 guuugagaac uauguaaauu augcugguag caaaac 36 guuugcgagu aguguaauuc uguaaaucuc uaaaac 36 guuugagaau gauguaauuu cauauaggua uuaaac 36 guuuuggggc agugucguuu ugacugguaa ucaaac 36 gucucaggua gaugucagau caaucaguuc aagagc 36 627 Page 1363 of 3790 guuuuagaug guuguuagau caauaagguu uagauc 36 guuuuagaug guuguuagau caauaagguu uagauc 36 gcuucagaug ugugucagau caaugaggua gaaccc 36 guuucagaug ccugucagau caaugacuuu gaccac 36 guuuuagcac uauguuuauu uagaaagagg uaaaac 36 auuuuaguaa cugaauaauu uacgugacug uaaaac 36 guuuuuguau ucucaauaau uucuuaucag uaaaac 36 634 Page 1364 of 3790 guuuuuguac ucucaagauu uaaguaacug uacaac 36 guuuuaguac ucuguaauuu uagguauaag ugauac 36 guuuuguuac cauauggauu uuugcuagau uaagac 36 guuuuggugu aguaucauuc uuauguauuc uuaaac 36 guuuuugugc uguacaauuu cuuacuagag uaaaac 36 guuuuagcac uguacaauac uuguguaagc aauaac 36 guuuuagugu uguacaauau uuggguaaac aauaac 36 641 Page 1365 of 3790 guuuuggggu uguacaauua uuuuguuaag uaaaac 36 agcauagcau uucggagugc ggcagggagc uaugac 36 auuauagcau aucgagaauu uacuaggaac uauaac 36 auuauagcau aucggagccu gaauuggagc uauaac 36 aguguagcua uccgggguga gagagggagc uacaac 36 guuguagcuc ccuuucucau uucgcagugc uacaau 36 guuguaguuc ccucucucau uucgcagugc uacaau 36 648 Page 1366 of 3790 guuauaguuu ccuuccucuc ucagaugugc uauaau 36 auuauagcga ggaauggcug aguaggcggc uauaac 36 guuuuagucc cuuuuuaaau uucuuuaugg uaaaau 36 guuuuagucc cuuuuuaaau uucuuuaugg uaaaau 36 auuuuagcau aaacauauuu augaaguggc uaaaac 36 auuauaccau accaagugau aacagggaau uacaac 36 gaucuauuuu agcugaaaac ugaaggaauc aauagc 36 655 Page 1367 of 3790 agccuaccac ggggaaaucg guagggaagc cacggc 36 aguauagcac ucuggugauu gagagccuag agcaac 36 auuguagcuc acugggauau gcgcacuggc cggaac 36 agguuagcag aucgggaauu gcgcucuggc uacaac 36 aguguagccg auggggaucg gggguccagc cgcaac 36 aguuuagcug uucagaauuc gggguccagc cgcaac 36 acucuaccau ggcggugugg gacggggcca uggaac 36 662 Page 1368 of 3790 RNA Rhodospirillum rubrum 662 acucuaccau ggcggugugg gacggggcca uggaac 663 RNA Spirochaeta Buddy 663 ggucaaucuu aacaaaaauc agcggucauc cccaac 664 36 RNA Prevotella ruminicola 664 guugugguuu gauguaggaa aggaaugaua uacaac 665 36 RNA Flavobacterium columnare 665 guugugguuu gauuaaagau uagaaaacac gauauu 666 36 RNA Parvibaculum lavamentivorans 666 agaguagcaa aucgagagac ggccgcaauc cgcagc 667 RNA Capnocytophaga ochracea 667 uguuaucaau cgcaaaacua caaaauuuga aagcaauuca caac 668 48 RNA Fibrobacter succinogenes 668 guuguuauug cacuaguaaa acuagaaaau cugaaagcaa uucacaac 669 Page 1369 of 3790 guuuuaagac cccucaaaac cccacccugu uacaau 36 guuguacugu gccuuauuuu ggauucaagg caaaac 36 guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguu 44 guuuuagagc uannnnnuag caaguuaaaa uaaguuaaaa uaaggcuagu ccguuaucaa 60 guuuuagagc uaugcugaaa agcauagcaa guuaaaaaua aguuaaaaua aggcuagucc 60 guuaucaa 68 674 69 Page 1370 of 3790 RNA Artificial Sequence Synthetic nucleic acid sequence 674 guuuuagagc uaugcuguuu uggaaacaaa acagcauagc aaguuaaaau aaggcuaguc cguuaucaa 675 70 RNA Artificial Sequence Synthetic nucleic acid sequence 675 guuuuagagc uaguuuuaga gcuagaaaua gcaaguuaaa auuagcaagu uaaaauaagg cuaguccguu 676 70 RNA Artificial Sequence Synthetic nucleic acid sequence 676 guuuuagagc uauagcaagu uaaaaugaaa guuuuagagc uauagcaagu uaaaauaagg cuaguccguu 677 74 RNA Artificial Sequence Synthetic nucleic acid sequence 677 guuuuagagc uagaaauagc aaguuaaaau guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguu 678 Page 1371 of 3790 guuuuagagc uaugcuguuu uggaaacaaa acagcauagc aaguuaaaau guuuuagagc 60 uaugcuguuu uggaaacaaa acagcauagc aaguuaaaau aaggcuaguc cguuaucaa 119 679 12 RNA Artificial Sequence Synthetic nucleic acid sequence 679 guuuuagagc ua 12 680 218 RNA Artificial Sequence Synthetic nucleic acid seguence misc_feature (1)..(80) n at each of these positions can be present or absent such that this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u misc_feature (93)..(192) n at each of these positions can be present or absent such that this region can contain anywhere from 3 to 100 nucleotides. n is a, c, g, or u 681 219 RNA Artificial Seąuence Synthetic nucleic acid seguence misc_feature (1)..(80) n at each of these positions can be present or absent such that Page 1372 of 3790 this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u misc_feature (93)..(192) n at each of these positions can be present or absent such that this region can contain anywhere from 3 to 100 nucleotides. n is a, c, g, or u 682 163 RNA Artificial Sequence Synthetic nucleic acid seguence misc_feature (1)..(80) n at each of these positions can be present or absent such that this region can contain anywhere from 12 to 80 nucleotides. n is a, c, g, or u 683 39 RNA Artificial Seguence Synthetic nucleic acid seguence 683 aucaacuuga aaaaguggca ccgagucggu gcuuuuuuu 684 33 RNA Artificial Seguence Synthetic nucleic acid seguence Page 1373 of 3790 684 aaaaucaaag gaucuucuug agauccuuuu uuu 33 685 34 RNA Artificial Sequence Synthetic nucleic acid sequence 685 cgccgaaaac cccgcuucgg cgggguuuug ccgc 34 686 34 RNA Artificial Sequence Synthetic nucleic acid sequence 686 cgcaaaaaac cccgcuucgg cgggguuuuu ucgc 34 687 39 RNA Artificial Sequence Synthetic nucleic acid sequence 687 aaaaaaaaac cccgccccug acagggcggg guuuuuuuu 39 688 40 RNA Artificial Sequence Synthetic nucleic acid sequence 688 cgcaaaaaac cccgccccug acagggcggg guuuuuucgc 40 689 41 RNA Artificial Sequence Synthetic nucleic acid sequence 689 ucacacuggc ucaccuucgg gugggccuuu cugcguuuau a Page 1374 of 3790 690 46 RNA Artificial Seguence Synthetic nucleic acid seguence 690 agagaauaua aaaagccaga uuauuaaucc ggcuuuuuua uuauuu 691 80 RNA Artificial Seguence Synthetic nucleic acid seguence 691 ccaggcauca aauaaaacga aaggcucagu cgaaagacug ggccuuucgu uuuaucuguu guuugucggu gaacgcucuc 692 123 RNA Artificial Seguence Synthetic nucleic acid seguence 692 aucaaaauuu acggcuuuga aaaaguaauu ucgugaccuu cgguauaagg uuacuacuag auucaggugc ucaucagaug caccacauuc ucuauaaaaa aaaaugguau cuuucuuauu uga 693 129 RNA Artificial Seguence Synthetic nucleic acid seguence 693 ccaggcauca aauaaaacga aaggcucagu cgaaagacug ggccuuucgu uuuaucuguu guuugucggu gaacgcucuc uacuagaguc acacuggcuc accuucgggu gggccuuucu gcguuuaua 120 123 120 129 694 129 RNA Page 1375 of 3790 Artificial Sequence Synthetic nucleic acid sequence 694 695 139 RNA Artificial Sequence Synthetic nucleic acid sequence 695 696 225 RNA Artificial Sequence Synthetic nucleic acid sequence 696 697 53 RNA Artificial Sequence Synthetic nucleic acid sequence 697 aacuuucagu uuagcggucu guuuuagagc uagaaauagc aaguuaaaau aag 53 698 31 DNA Artificial Seguence Page 1376 of 3790 Synthetic nucleic acid sequence 698 aaggtaccca gaccgctaaa ctgaaagtta c 31 699 31 DNA Artificial Sequence Synthetic nucleic acid sequence 699 gtaactttca gtttagcggt ctgggtacct t 31 700 40 DNA Artificial Sequence Synthetic nucleic acid sequence 700 agtttttaaa agagcttggc ggttgtttta gtcccttttt 40 701 42 DNA Artificial Sequence Synthetic nucleic acid sequence 701 caaagtttca ttagttgaat ttaactgttt tagtcccttt tt 42 702 42 DNA Artificial Sequence Synthetic nucleic acid sequence 702 aagaatgagg atgatgatat tttacagttt tagtcccttt tt 42 Page 1377 of 3790 703 gtgtgctaaa aaaaatggac ttaaatgttt tagtcccttt tt 704 74 DNA Artificial Sequence Synthetic nucleic acid sequence 704 aagaaattta aaaagggact aaaataaaga gtttgcggga ctctgcgggg ttacaatccc 60 ctaaaaccgc tttt 74 705 54 DNA Artificial Sequence Synthetic nucleic acid sequence 705 ataactcgac caatatttga caaagtttca gttgctgaat tatttggtaa acct 54 706 58 DNA Artificial Sequence Synthetic nucleic acid sequence 706 ggcaggtttt gtatggtcat ataggagtgt ttcagttgct gaattatttg gtaaacct 58 707 69 DNA Artificial Sequence Synthetic nucleic acid sequence 707 agctataggg ttacctatct tttgagtgtt ggcaaataag tttcagttgc tgaattattt 60 ggtaaacct 708 54 DNA Artificial Seguence Page 1378 of 3790 Synthetic nucleic acid seąuence 708 atgcttttaa actactgata tatacgtttc agttgctgaa ttatttggta aact 54 709 80 DNA Artificial Sequence Synthetic nucleic acid sequence 709 gtaccaaata attaatgctc tgtaatcatt taaaagtatt ttgaacggac ctctgtttga 60 cacgtctgaa taactaaaaa 80 710 52 DNA Artificial Sequence Synthetic nucleic acid sequence 710 tatccattcc cagccggaaa ttaagttgta gctccctttc tcatttcgca gt 52 711 53 DNA Artificial Sequence Synthetic nucleic acid sequence 711 gcctttttac aagctcgctt tctttgttgt agctcccttt ctcatttcgc agt 53 712 53 DNA Artificial Sequence Synthetic nucleic acid sequence 712 taaaggtttc tgttgcgacc cgaatgttgt agctcccttt ctcatttcgc agt 53 Page 1379 of 3790 713 taactttgac cgtgtgcaat ccagttagtt gtagctccct ttctcatttc gcagt 55 714 52 DNA Artificial Sequence Synthetic nucleic acid sequence 714 aacccactaa attttgcaaa tgcggttgta gctccctttc tcatttcgca gt 52 715 53 DNA Artificial Sequence Synthetic nucleic acid sequence 715 tttttttgta ctgttgtttg aacgagttgt agctcccttt ctcatttcgc agt 53 716 55 DNA Artificial Sequence Synthetic nucleic acid sequence 716 ttcgtttcag atagcaaacg cagtagtgtt gtagctccct ttctcatttc gcagt 55 717 84 DNA Artificial Sequence Synthetic nucleic acid sequence 717 atatgacggt gggcaactgg tacaggttgt agctcccttt ctcatttcgc agtgctacaa 60 tgccggatat gacggtgggc aact 84 Page 1380 of 3790 718 cttttgtatt gattcaaggt gcttgttgta gctccctttc tcatttcgca gt 52 719 55 DNA Artificial Seąuence Synthetic nucleic acid seąuence 719 attcgtcgat gatggaaact cgagcatgtt gtagctccct ttctcatttc gcagt 55 720 55 DNA Artificial Seąuence Synthetic nucleic acid seąuence 720 tagccagtgc taaaaccgca cccgcttgtt gtagctccct ttctcatttc gcagt 55 721 54 DNA Artificial Seąuence Synthetic nucleic acid seąuence 721 atagaaatac atacgccgag taattagttg tagctccctt tctcatttcg cagt 54 722 54 DNA Artificial Seąuence Synthetic nucleic acid seąuence 722 tttttgtaat tgttctgcct tttttagttg tagctccctt tctcatttcg cagt 54 723 53 DNA Artificial Seąuence Synthetic nucleic acid seąuence 723 acggcggaaa ccattgccac aaaacgttgt agctcccttt ctcatttcgc agt 53 Page 1381 of 3790 724 54 DNA Artificial Seąuence Synthetic nucleic acid seąuence 724 aataataacc caatacacga tgttaagttg tagctccctt tctcatttcg cagt 725 171 DNA Artificial Seąuence Synthetic nucleic acid seąuence 725 ttgtcttatt tatatacaaa tagattattg acttatcatc tcacaacggc tagaatccca aacatattgt cgcactgcga aatgagaacc gttgctacaa taaggccgtc tgaaaagatg tgccgcaacg ctctgcccct taaagcttct gctttaaggg gcatcgttta t 726 35 DNA Artificial Seąuence Synthetic nucleic acid seąuence 726 ggtaactttg cctaggatag ttttagagct atgtt 727 22 DNA Artificial Seąuence Synthetic nucleic acid seąuence 727 cattatgttt tagagctatg tt 120 171 728 24 DNA Artificial Seąuence Synthetic nucleic acid seąuence 728 gagttttaga gctatgttat tttg Page 1382 of 3790 729 27 DNA Artificial Sequence Synthetic nucleic acid sequence 729 ttatagtttt agagctatgt tattttg 27 730 26 DNA Artificial Sequence Synthetic nucleic acid sequence 730 taaatgtttt agagctatgt tatttt 26 731 23 DNA Artificial Sequence Synthetic nucleic acid sequence 731 tacaagtttt agagctatgt tat 23 732 30 DNA Artificial Sequence Synthetic nucleic acid sequence 732 ttcatgttgt tttagagcta tgttattttg 30 733 28 DNA Artificial Sequence Synthetic nucleic acid sequence 733 gttttagagc tatgctattt cgaatact 28 734 Page 1383 of 3790 92 DNA Artificial Sequence Synthetic nucleic acid sequence 734 attgttagta ttcaaaataa catagcaagt taaaataagg ctttgtccgt tatcaacttt 60 taattaagta gcgctgtttc ggcgcttttt tt 92 735 43 DNA Artificial Sequence Synthetic nucleic acid sequence 735 gccattaatt aatatggtga gttttagagc tgtgttgttt ega 43 736 43 DNA Artificial Sequence Synthetic nucleic acid sequence 736 getagegeag ttagtgctct gttttagagc tgtgttgttt ega 43 737 43 DNA Artificial Sequence Synthetic nucleic acid sequence 737 tgttgtgtca teatagttag gttttagagc tgtgttgttt ega 43 738 43 DNA Artificial Sequence Synthetic nucleic acid sequence 738 caattagaca atagacaaac gttttagagc tgtgttgttt ega 43 739 44 Page 1384 of 3790 DNA Artificial Seąuence Synthetic nucleic acid seąuence 739 ttcggacatg acttgccaca gttttagagc tgtgttgtta tcga 44 740 107 DNA Artificial Seąuence Synthetic nucleic acid seąuence 740 gttggaatca ttcgaaacaa cacagcaagt taaaataagg cagtgatttt taatccagtc 60 cgtacacaac ttgaaaaagt gcgcaccgat tcggtgcttt tttattt 107 741 20 RNA Artificial Seąuence Synthetic nucleic acid seąuence 741 ugguccgcug ccguucgcuu 742 20 RNA Artificial Seąuence Synthetic nucleic acid seąuence 742 gcagaaaaaa accauggguu 743 20 RNA Artificial Seąuence Synthetic nucleic acid seąuence 743 aaaaaaccgg uucagcugcc 744 20 RNA Page 1385 of 3790 aacuuucagu uuagcggucu 2 0 aggacaguuu cagguagucc 20 aaccgguuuu uuagccaugu 2 0 uugacagcua gcucaguccu 2 0 cccggaagag agucaauuca 2 0 Page 1386 of 3790 Synthetic nucleic acid seguence 749 cccugaauug acucucuucc 2 0 750 20 RNA Artificial Seguence Synthetic nucleic acid seguence 750 gaauucauua aagaggagaa 20 751 20 RNA Artificial Seguence Synthetic nucleic acid seguence 751 gaauggugca aaaccuuucg 20 752 141 DNA Artificial Seguence Synthetic nucleic acid seguence 752 cgacaccatc gaatggtgca aaacctttcg cggtatggca tgatagcgcc cggaagagag 60 tcaattcagg gtggtgaatt tgacagctag ctcagtccta ggtataatag atctgaattc 120 attaaagagg agaaaggtac c 141 753 20 RNA Artificial Seguence Synthetic nucleic acid seguence 753 aacuuucagu uuagcggucu 2 0 754 20 RNA Artificial Seguence Page 1387 of 3790 uggaaccgua cuggaacugc 20 gguaguccgg gaugucagcc 2 0 aggacaguuu cagguagucc 20 gucuugcagg gaggaguccu 2 0 gcauaaccgg accgucggac 2 0 Page 1388 of 3790 759 cuuucagagc accgucuucc 20 gaugguguag ucuucguugu 20 caucuaauuc aacaagaauu 20 caucuaauuc aacaagaauu 20 aguagugcaa auaaauuuaa 20 acaaguguug gccacggaac 2 0 Page 1389 of 3790 uuucauguga uccggauaac 2 0 cguuccugua cauaaccuuc 20 uaacucgaua cgauuaacaa 20 auaauggucu gcuaguugaa 2 0 auguggucac gcuuuucguu 2 0 770 20 Page 1390 of 3790 aacuuucagu uuagcggucu 2 0 uggaaccgua cuggaacugc 20 gaugguguag ucuucguugu 20 uuccggguac auacguucgg 20 gguaguccgg gaugucagcc 2 0 Page 1391 of 3790 aggacaguuu cagguagucc 20 uugacagcua gcucaguccu 2 0 aaccgguuuu uuagccaugu 2 0 aaaaaaccgg uucagcugcc 2 0 uugggaaggg cgaucggugc 2 0 Page 1392 of 3790 780 gcuggccugg uucaccacgc 2 0 guagccaaau cgggaaaaac 20 cgguaagccu ucgcacauau 2 0 acaagaacca uucgagaguc 2 0 gucaagcagc aguauaugcu 20 ugugaguuag cucacucauu 2 0 Page 1393 of 3790 auguugugug gaauugugag 20 cuuccggcuc guauguugug 2 0 gggcgaggag cuguucaccg 2 0 ggccacaagu ucagcguguc 2 0 gcccuugcuc accaugguug 20 791 20 Page 1394 of 3790 Gly Ser Cys Gly Trp Ala Val Leu Asn Gin Lys Ala Lys Asp Glu Asn 20 25 30 Ile Val Ala Leu Gly Ser Trp Cys Phe Asp Val Pro Glu Thr Asp Lys 35 40 45 Page 1395 of 3790 Glu Arg Ile Pro Thr Asn Gin Ile Arg Arg Ala Asn Arg Leu Leu Arg 50 55 60 Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala Glu Ile Arg Arg Leu 65 70 75 80 Phe Ala Ser Lys Gly Met Leu Asp Thr Ala Asp Pro Asp Ala Leu Ala 85 90 95 Lys Ile Ser Ala Asp Pro Trp Glu Met Arg Ala Lys Gly Leu Asp Tyr 100 105 110 Gin Leu Thr Pro Gin Glu Phe Ala Val Ala Leu Gly His Ile Ala Lys 115 120 125 Arg Arg Gly Phe Lys Ser Ala Ala Lys Arg Val Ser Thr Asn Ala Pro 130 135 140 Ser Glu Asp Ser Lys Met Leu Ala Ala Leu Glu Lys Thr Lys Glu Gin 145 150 155 160 Ser Ala Gin Tyr Arg Thr Ile Gly Glu Met Phe Ala Arg Asp Pro Ala 165 170 175 Tyr Ala Asp Arg Arg Arg Asn Arg Asp Gly Cys Phe Asp Arg Thr Met 180 185 190 Ser Arg Glu Asp Leu Phe Lys Glu Thr Gin Ile Leu Phe Glu Ser Gin 195 200 205 Arg Arg Leu Gly Asn Phe Ser Ala Thr Ser Glu Thr Glu Gin Ala Phe 210 215 220 Ile Asp Ile Ala Phe Arg Gin Lys Pro Met Gin Asp Ser Glu Arg Leu 225 230 235 240 796 400 PRT Acetobacter aceti 796 Ser Phe Glu Arg Phe Arg Leu Leu Cys Arg Leu Val Asn Leu Arg Val 15 10 15 Thr Asp Gly Leu Glu Asp Arg Pro Leu Thr Pro Glu Glu Leu Arg Leu 20 25 30 Page 1396 of 3790 Ala Cys Glu Asp Ala Gly Lys Thr Arg Lys Leu Ser Val Lys Lys Val 35 40 45 Arg Ser Leu Ile Gly Leu Arg Asp Asp Gin Arg Phe Thr Thr Ile Pro 50 55 60 Pro Asp Gin Glu Gin His Asp Ile Ala Ala Arg Thr Gly Asp Ala Leu 65 70 75 80 Thr Gly Thr Ala Thr Phe Arg Ala Ile Leu Gly Glu Ser Phe Trp Arg 85 90 95 Gin Leu Leu Pro His Pro Glu Gin Leu Asp Arg Ala Ala Trp Ile Ile 100 105 110 Ser Phe His Glu Leu Thr Asp Thr Ile Ile Ser Lys Leu Ala Thr Ile 115 120 125 Gly Leu Pro Ser Glu Val Met Glu Leu Ile Arg Lys Ala Leu Glu Asp 130 135 140 Gly Lys Phe Ser Lys Phe Lys Gly Ala Ala Ser Leu Ser Asp Lys Ala 145 150 155 160 Ala Arg Lys Leu Ile Pro Phe Leu Gin Glu Gly Leu Thr Tyr Asp Lys 165 170 175 Ala Cys Gin Lys Ala Gly Tyr Asn His Ala Ala Ser Lys Phe Thr His 180 185 190 Tyr Asp Ser Ile Asp Thr Lys Ala Lys Phe Asn Ser Leu Met Asp Asp 195 200 205 Val Arg Asp Ser Ile Thr Asn Pro Val Ala Arg Lys Ala Ile Ser Glu 210 215 220 Gly Met Lys Gin Val Trp Ala Met Arg Asn Gin Trp Gly Leu Pro Gly 225 230 235 240 Ala Ile Cys Ile Glu Leu Ala Arg Asp Val Gly Asn Ser Ala Glu Lys 245 250 255 Arg Arg Glu Ile Glu Ser Gly Ile Lys Lys Asn Thr Ala Gin Arg Glu 260 265 270 Arg Glu Arg Gin Glu Ala Lys Glu His Leu Asn Gin Ser Asp Ile Ser Page 1397 of 3790 Arg Asp Val Pro Met Pro Trp Glu Gly Phe Arg His Gin Leu Glu Thr 325 330 335 Thr Leu Glu Ser Ile Arg Lys Tyr Asn Val Asn Arg Phe Gly Asp Ile 340 345 350 Page 1399 of 3790 Page 1400 of 3790 Phe Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Gin Arg 195 200 205 Gin Thr Asp Leu Gly Asn Pro His Thr Ser Ala Lys Leu Leu Glu Asn 210 215 220 Leu Thr Ala Leu Leu Met Trp Gin Lys Pro Ala Leu Ala Gly Glu Ala 225 230 235 240 Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Pro Thr Glu Tyr Lys 245 250 255 Ala Ala Lys Asn Ser Tyr Ser Ala Glu Arg Phe Val Trp Leu Thr Lys 260 265 270 Leu Asn Asn Leu Arg Ile Leu Glu Gin Gly Ala Glu Arg Ala Leu Thr 275 280 285 Asp Asn Glu Arg Phe Ala Leu Leu Asp Gin Pro Tyr Glu Lys Ala Lys 290 295 300 Phe Thr Tyr Ala Gin Ala Arg Thr Met Leu Ala Leu Pro Asp Glu Ala 305 310 315 320 Ile Phe Lys Gly Val Arg Tyr Gin Gly Glu Asp Lys Lys Ala Val Glu 325 330 335 Thr Lys Thr Ile Leu Met Glu Met Lys Ala Tyr His Gin Ile Arg Lys 340 345 350 Ala Leu Glu Asn Ala Asp Leu Lys Ala Glu Trp Asn Glu Leu Lys Asn 355 360 365 Asn Ser Glu Leu Leu Asp Asp Ile Gly Thr Ala Phe Ser Leu His Lys 370 375 380 Thr Asp Glu Asp Ile Cys Arg Tyr Leu Asp Gly Lys Leu Ser Glu Ser 385 390 395 400 Ile Leu Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gin 405 410 415 Leu Ser Leu Lys Ala Leu Gin Gin Ile Leu Pro Leu Met Leu Gin Gly 420 425 430 Gin Arg Tyr Asp Glu Ala Val Ser Ala Ile Tyr Gly Asp His Tyr Gly 435 440 445 Page 1401 of 3790 Lys Lys Ser Ala Glu Ile Asn Arg Leu Leu Pro Thr Ile Pro Ala Asp 450 455 460 Glu Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gin Ala Arg Lys 465 470 475 480 Val Ile Asn Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His 485 490 495 Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Gin Asp Arg Lys Lys 500 505 510 Leu Glu Lys Gin Gin Glu Asp Asn Arg Lys Gin Arg Glu Ser Ala Val 515 520 525 Lys Lys Phe Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Gly 530 535 540 Lys Asp Ile Leu Lys Met Arg Leu Tyr Glu Leu Gin Gin Ala Lys Cys 545 550 555 560 Leu Tyr Ser Gly Lys Ser Leu Glu Leu His Arg Leu Leu Glu Lys Gly 565 570 575 Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp 580 585 590 Ser Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gin Asn Lys 595 600 605 Gly Asn Leu Thr Pro Tyr Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu 610 615 620 His Trp Gin Asn Phe Val Ala Arg Val Gin Thr Ser Gly Phe Ser His 625 630 635 640 Thr Lys Lys Gin Arg Ile Leu Ser His Lys Leu Asp Glu Lys Gly Phe 645 650 655 Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys 660 665 670 Asn Phe Ile Ala Asp Asn Met Leu Leu Thr Gly Lys Gly Lys Arg Lys 675 680 685 Val Phe Ala Ser Asn Gly Gin Ile Thr Ala Leu Leu Arg Gly Arg Trp 690 695 700 Page 1402 of 3790 Gly Leu Gin Lys Val Arg Asp Asp Asn Asp Arg His His Ala Leu Asp 705 710 715 720 Ala Val Val Val Ala Cys Ser Thr Val Val Met Gin Gin Lys Ile Thr 725 730 735 Arg Phe Val Arg Tyr Glu Glu Gly Asn Val Phe Ser Gly Glu Arg Ile 740 745 750 Asp Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ser Pro Trp 755 760 765 Ala Phe Phe Arg Glu Asn Val Glu Ile Arg Ile Phe Ser Glu Asn Pro 770 775 780 Lys Leu Glu Leu Glu Asn Arg Leu Pro Asp Tyr Pro Gin Tyr Asn His 785 790 795 800 Glu Phe Val Gin Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met 805 810 815 Thr Gly Gin Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asp 820 825 830 Glu Gly Leu Ser Val Leu Lys Val Pro Leu Thr Gin Leu Lys Leu Ser 835 840 845 Asp Leu Glu Arg Met Val Asn Arg Glu Arg Glu Val Thr Leu Tyr Glu 850 855 860 Ser Leu Lys Ala Arg Leu Glu Gin Phe Gly Asn Asp Pro Ala Lys Ala 865 870 875 880 Phe Ala Glu Pro Phe His Lys Lys Gly Gly Ala Val Val Lys Ala Val 885 890 895 Arg Val Glu Gin Thr Gin Lys Ser Gly Val Leu Val Arg Asp Gly Asn 900 905 910 Gly Val Ala Asp Asn Ala Ser Met Val Arg Val Asp Val Phe Thr Lys 915 920 925 Gly Gly Lys Tyr Phe Leu Val Pro Ile Tyr Thr Trp Gin Val Ala Lys 930 935 940 Gly Ile Leu Pro Asn Lys Ala Val Thr Ala Asn Val Asp Glu Ile Asp 960 945 950 Page 1403 of 3790 955 Arg 799 239 PRT Actinobacillus ureae 799 Met Glu Ile Arg Ile Phe Ser Glu Asn Pro Lys Leu Gly Leu Glu Asn 15 10 15 Arg Leu Pro Gly Tyr Pro Gin Tyr Asn His Glu Phe Val Gin Pro Leu 20 25 30 Phe Val Ser Arg Met Pro 35 Thr Arg Lys 40 Met Thr Gly Lys 45 Gly His Met Glu Thr Val Lys 50 Ser Ala Lys 55 Arg Leu Asp Glu Gly Leu Ser Val Leu Lys Val 65 Pro Leu Thr Gin Leu 70 Lys Leu Ser Asp Leu 75 Glu Arg Met Val Asn Arg Glu Arg Glu Asp Ala 85 Leu Tyr Gin 90 Ser Leu Lys Ala His Leu Glu Gin Phe Gly Asn Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe His 225 230 235 800 400 PRT Actinobacillus ureae 800 Arg Leu Leu Lys Ala Glu Asn Leu Leu Leu Ser Ala Asp Glu Ile Leu Page 1406 of 3790 Page 1407 of 3790 Pro Ser Glu Phe Leu Gin Gly Leu Asn Gin Arg Val Ser Glu Lys Leu 165 170 175 Gly Thr Glu Leu Asp Pro Gly Leu Thr Gin Gly Gin Leu Val Ala Lys 180 185 190 Leu Leu His Arg Phe Pro Asn Ala Lys Ile Arg Gly Pro Glu Gly Ile 195 200 205 Leu Arg Gly Lys Leu His Gin Ser Asp Asn Ala Gly Glu Leu Arg Leu 210 215 220 Ile Cys Arg Thr Gin Gly Leu Asp Cys His Ile Thr Glu Glu Leu Val 225 230 235 240 Arg Leu Val Phe Gin Ala Lys Ser Pro Lys Ala Asn Lys Glu Met Arg 245 250 255 Lys Arg Ile Gly Arg Asp Gin Leu Pro Gly Gin Gly Ala His Ile Arg 260 265 270 Ala Glu Lys Ala His Pro Val Phe Gin Arg Phe Arg Ile Val Ala Val 275 280 285 Leu Ala Asn Leu Arg Ile Arg Glu Ala His Val Asp Arg Arg Leu Thr 290 295 300 Ala Glu Glu Met Arg Thr Leu Thr Asp Phe Leu Leu Gly Leu Ala Gly 305 310 315 320 Ser Glu Gin Pro Thr Trp Glu Glu Leu Ala Asp Asn Leu Asn Ile Glu 325 330 335 Arg His Gin Leu Arg Gly Thr Ala Lys Ala Ser Val Asp Gly Ala Pro 340 345 350 Ala Leu Arg Phe Pro Pro Ile Asp Ala Thr Thr Asp Arg Ile Tyr Ala 355 360 365 Ser Lys Leu Lys Trp Leu Ala Glu Trp Trp Arg Gin Ala Asp Glu Glu 370 375 380 Arg Arg Gly Tyr Met Val Asp Ala Leu Ser Asn Ser Gly Gly Ser Glu 385 390 395 400 Asp Glu Pro Tyr Leu Asp Asp Glu Ile Ala Glu Met Leu Glu Gin Ala 405 410 415 Page 1408 of 3790 Ser Glu Glu Asp Gin Ala Lys Leu Asp Ser Leu His Leu Pro Gly Gly 420 425 430 Arg Ala Ser Tyr Cys Leu Asp Thr Leu Arg Arg Leu Thr Asp Ala Met 435 440 445 Leu Gly Gly Gly Leu Asp Leu Phe Glu Ala Arg Lys Ala Val Phe His 450 455 460 Val Asp Asp Asp Trp Ala Pro Pro Thr Asp Pro Ile Gly Ala Pro Val 465 470 475 480 Gly Asn Pro Pro Val Asp Arg Val Leu Lys His Val Ala Arg Trp Leu 485 490 495 Glu Ala Ala Thr Gly Arg Trp Gly Ala Pro Gin Thr Ile Asn Ile Glu 500 505 510 His Val Arg Glu Gly Leu Gly Ser Glu Lys Ala Ala Arg Glu Leu Thr 515 520 525 Arg Met Asn Asp Arg Arg Arg Arg Asn Asn Gin Lys Leu Val Glu Glu 530 535 540 Met Gly Glu Lys Leu Gly Met Ser Gly Arg Ile Arg Arg Ser Asp Arg 545 550 555 560 Met Arg Tyr Glu Ala Ile Arg Arg Gin Asn Cys Glu Cys Leu Tyr Cys 565 570 575 Gly Gin Pro Ile Thr Tyr Gin Thr Met Glu Met Asp His Ile Val Pro 580 585 590 Arg Ala Gly Ala Ala Ser Thr Asn Ser Arg Ser Asn Leu Ala Ala Val 595 600 605 Cys Arg Arg Cys Asn His Gin Lys Gly Lys Leu Pro Phe Ala Val Trp 610 615 620 Ala Glu Ser Gin Asp Ser Pro Ala Glu Val Arg Leu Gin Asp Ala Val 625 630 635 640 Gin Arg Val Arg His Trp Leu Arg Asp Ala Gly Met Gly Gin Lys Glu 645 650 655 Leu Gin Ala Leu Arg Val Gin Val Ile Ala Arg Leu Lys Ser Lys Arg 660 665 670 Page 1409 of 3790 Pro Asp Glu Glu Phe Asp Gly Arg Ser Met Glu Ser Ile Ala Trp Met 675 680 685 Ala Asn Glu Leu Arg Ala Arg Val Glu Ala Gin Tyr Arg Gly Ser Gly 690 695 700 Thr Thr Val Arg Val Tyr Arg Gly Ala Leu Thr Ala Glu Ala Arg Lys 705 710 715 720 Ala Ser Gly Phe Glu Gly Arg Val Asn Leu Ile Gly Gly Arg Gly Lys 725 730 735 Asp Arg Phe Asp Arg Arg His His Ala Met Asp Ala Leu Val Ile Ala 740 745 750 Leu Met Asn Gin Ser Val Ala Gin Thr Leu Ala Leu Arg Leu Asn Met 755 760 765 Arg Asp Ser Gin Trp Leu Thr Gin Ser Glu Gin Thr Trp Arg Gin Phe 770 775 780 His Gly Ala Pro Gly Glu Ala Ala Arg Lys Trp Glu Ala Trp Asp Arg 785 790 795 800 Asp Met Arg Asp Ala Ser Asp Leu Phe Asn Leu Ala Leu Asp Gly Gly 805 810 815 Arg Ile Pro Ile Thr Glu Asn Val Arg Leu Arg Val Gly Asn Gly Arg 820 825 830 Val His Glu Asp Gly Val Ile Arg Phe Lys Pro Glu Tyr Glu Val Lys 835 840 845 Gly Lys Thr Ile Lys Gly Gly Glu Ala Arg Leu Leu Gly Asp Ser Leu 850 855 860 Pro Ser Glu Gin Ile Asp Arg Ala Glu Thr Pro Ala Leu Trp Thr Ala 865 870 875 880 Leu Thr Arg Leu Pro Glu Tyr Asp Arg Lys Ser Gly Leu Pro Glu Asn 885 890 895 Pro Asp Arg Val Ile Arg Val Asn Gly Ala Val Val Gin Ala Thr Asp 900 905 910 Arg Ile Arg Phe Phe Gly Thr Pro Ala Ser Val Ala Val Arg Gly Gly Page 1410 of 3790 802 1101 PRT Actinomyces naeslundii 802 Met Trp Tyr Ala Ser Leu Met Ser Ala His His Leu Arg Val Gly Ile 15 10 15 Asp Val Gly Thr His Ser Val Gly Leu Ala Thr Leu Arg Val Asp Asp Page 1411 of 3790 25 30 His Gly Thr Pro Ile Glu Leu Leu Ser Ala Leu Ser His Ile His Asp 35 40 45 Ser Gly Val Gly Lys Glu Gly Lys Lys Asp His Asp Thr Arg Lys Lys 50 55 60 Leu Ser Gly Ile Ala Arg Arg Ala Arg Arg Leu Leu His His Arg Arg 65 70 75 80 Thr Gin Leu Gin Gin Leu Asp Glu Val Leu Arg Asp Leu Gly Phe Pro 85 90 95 Ile Pro Thr Pro Gly Glu Phe Leu Asp Leu Asn Glu Gin Thr Asp Pro 100 105 110 Tyr Arg Val Trp Arg Val Arg Ala Arg Leu Val Glu Glu Lys Leu Pro 115 120 125 Glu Glu Leu Arg Gly Pro Ala Ile Ser Met Ala Val Arg His Ile Ala 130 135 140 Arg His Arg Gly Trp Arg Asn Pro Tyr Ser Lys Val Glu Ser Leu Leu 145 150 155 160 Ser Pro Ala Glu Glu Ser Pro Phe Met Lys Ala Leu Arg Glu Arg Ile 165 170 175 Leu Ala Thr Thr Gly Glu Val Leu Asp Asp Gly Ile Thr Pro Gly Gin 180 185 190 Ala Met Ala Gin Val Ala Leu Thr His Asn Ile Ser Met Arg Gly Pro 195 200 205 Glu Gly Ile Leu Gly Lys Leu His Gin Ser Asp Asn Ala Asn Glu Ile 210 215 220 Arg Lys Ile Cys Ala Arg Gin Gly Val Ser Pro Asp Val Cys Lys Gin 225 230 235 240 Leu Leu Arg Ala Val Phe Lys Ala Asp Ser Pro Arg Gly Ser Ala Val 245 250 255 Ser Arg Val Ala Pro Asp Pro Leu Pro Gly Gin Gly Ser Phe Arg Arg 260 265 270 Page 1412 of 3790 Ala Pro Lys Cys Asp Pro Glu Phe Gin Arg Phe Arg Ile Ile Ser Ile 275 280 285 Val Ala Asn Leu Arg Ile Ser Glu Thr Lys Gly Glu Asn Arg Pro Leu 290 295 300 Thr Ala Asp Glu Arg Arg His Val Val Thr Phe Leu Thr Glu Asp Ser 305 310 315 320 Gin Ala Asp Leu Thr Trp Val Asp Val Ala Glu Lys Leu Gly Val His 325 330 335 Arg Arg Asp Leu Arg Gly Thr Ala Val His Thr Asp Asp Gly Glu Arg 340 345 350 Ser Ala Ala Arg Pro Pro Ile Asp Ala Thr Asp Arg Ile Met Arg Gin 355 360 365 Thr Lys Ile Ser Ser Leu Lys Thr Trp Trp Glu Glu Ala Asp Ser Glu 370 375 380 Gin Arg Gly Ala Met Ile Arg Tyr Leu Tyr Glu Asp Pro Thr Asp Ser 385 390 395 400 Glu Cys Ala Glu Ile Ile Ala Glu Leu Pro Glu Glu Asp Gin Ala Lys 405 410 415 Leu Asp Ser Leu His Leu Pro Ala Gly Arg Ala Ala Tyr Ser Arg Glu 420 425 430 Ser Leu Thr Ala Leu Ser Asp His Met Leu Ala Thr Thr Asp Asp Leu 435 440 445 His Glu Ala Arg Lys Arg Leu Phe Gly Val Asp Asp Ser Trp Ala Pro 450 455 460 Pro Ala Glu Ala Ile Asn Ala Pro Val Gly Asn Pro Ser Val Asp Arg 465 470 475 480 Thr Leu Lys Ile Val Gly Arg Tyr Leu Ser Ala Val Glu Ser Met Trp 485 490 495 Gly Thr Pro Glu Val Ile His Val Glu His Val Arg Asp Gly Phe Thr 500 505 510 Ser Glu Arg Met Ala Asp Glu Arg Asp Lys Ala Asn Arg Arg Arg Tyr 515 520 525 Page 1413 of 3790 Asn Asp Asn Gin Glu Ala Met Lys Lys Ile Gin Arg Asp Tyr Gly Lys 530 535 540 Glu Gly Tyr Ile Ser Arg Gly Asp Ile Val Arg Leu Asp Ala Leu Glu 545 550 555 560 Leu Gin Gly Cys Ala Cys Leu Tyr Cys Gly Thr Thr Ile Gly Tyr His 565 570 575 Thr Cys Gin Leu Asp His Ile Val Pro Gin Ala Gly Pro Gly Ser Asn 580 585 590 Asn Arg Arg Gly Asn Leu Val Ala Val Cys Glu Arg Cys Asn Arg Ser 595 600 605 Lys Ser Asn Thr Pro Phe Ala Val Trp Ala Gin Lys Cys Gly Ile Pro 610 615 620 His Val Gly Val Lys Glu Ala Ile Gly Arg Val Arg Gly Trp Arg Lys 625 630 635 640 Gin Thr Pro Asn Thr Ser Ser Glu Asp Leu Thr Arg Leu Lys Lys Glu 645 650 655 Val Ile Ala Arg Leu Arg Arg Thr Gin Glu Asp Pro Glu Ile Asp Glu 660 665 670 Arg Ser Met Glu Ser Val Ala Trp Met Ala Asn Glu Leu His His Arg 675 680 685 Ile Ala Ala Ala Tyr Pro Glu Thr Thr Val Met Val Tyr Arg Gly Ser 690 695 700 Ile Thr Ala Ala Ala Arg Lys Ala Ala Gly Ile Asp Ser Arg Ile Asn 705 710 715 720 Leu Ile Gly Glu Lys Gly Arg Lys Asp Arg Ile Asp Arg Arg His His 725 730 735 Ala Val Asp Ala Ser Val Val Ala Leu Met Glu Ala Ser Val Ala Lys 740 745 750 Thr Leu Ala Glu Arg Ser Ser Leu Arg Gly Glu Gin Arg Leu Thr Gly 755 760 765 Lys Glu Gin Thr Trp Lys Gin Tyr Thr Gly Ser Thr Val Gly Ala Arg 770 775 780 Page 1414 of 3790 Trp Arg Ile Cys Gly Tyr Asp Thr Asn Ser Lys Leu Thr Leu Lys Page 1415 of 3790 1025 1030 1035 Ser Ser Asn Glu Leu Leu Asp Ser His Ala Pro Trp His Ile Arg Lys Page 1417 of 3790 Leu Arg Gly Ser Ser Arg Ala Ser Leu Glu Thr Gly Gly Gly Leu Thr 385 390 395 400 Tyr Pro Pro Val Asp Asp Thr Thr Val Arg Val Met Ser Ala Glu Val 405 410 415 Asp Trp Leu Ala Asp Trp Trp Asp Cys Ala Asn Asp Glu Ser Arg Gly 420 425 430 His Met Ile Asp Ala Ile Ser Asn Gly Cys Gly Ser Glu Pro Asp Asp 435 440 445 Val Glu Asp Glu Glu Val Asn Glu Leu Ile Ser Ser Ala Thr Ala Glu 450 455 460 Asp Met Leu Lys Leu Glu Leu Leu Ala Lys Lys Leu Pro Ser Gly Arg 465 470 475 480 Val Ala Tyr Ser Leu Lys Thr Leu Arg Glu Val Thr Ala Ala Ile Leu 485 490 495 Glu Thr Gly Asp Asp Leu Ser Gin Ala Ile Thr Arg Leu Tyr Gly Val 500 505 510 Asp Pro Gly Trp Val Pro Thr Pro Ala Pro Ile Glu Ala Pro Val Gly 515 520 525 Asn Pro Ser Val Asp Arg Val Leu Lys Gin Val Ala Arg Trp Leu Lys 530 535 540 Phe Ala Ser Lys Arg Trp Gly Val Pro Gin Thr Val Asn Ile Glu His 545 550 555 560 Thr Arg Glu Gly Leu Lys Ser Ala Ser Leu Leu Glu Glu Glu Arg Glu 565 570 575 Arg Trp Glu Arg Phe Glu Ala Arg Arg Glu Ile Arg Gin Lys Glu Met 580 585 590 Tyr Lys Arg Leu Gly Ile Ser Gly Pro Phe Arg Arg Ser Asp Gin Val 595 600 605 Arg Tyr Glu Ile Leu Asp Leu Gin Asp Cys Ala Cys Leu Tyr Cys Gly 610 615 620 Asn Glu Ile Asn Phe Gin Thr Phe Glu Val Asp His Ile Ile Pro Arg 625 630 635 640 Page 1418 of 3790 Val Asp Ala Ser Ser Asp Ser Arg Arg Thr Asn Leu Ala Ala Val Cys 645 650 655 His Ser Cys Asn Ser Ala Lys Gly Gly Leu Ala Phe Gly Gin Trp Val 660 665 670 Lys Arg Gly Asp Cys Pro Ser Gly Val Ser Leu Glu Asn Ala Ile Lys 675 680 685 Arg Val Arg Ser Trp Ser Lys Asp Arg Leu Gly Leu Thr Glu Lys Ala 690 695 700 Met Gly Lys Arg Lys Ser Glu Val Ile Ser Arg Leu Lys Thr Glu Met 705 710 715 720 Pro Tyr Glu Glu Phe Asp Gly Arg Ser Met Glu Ser Val Ala Trp Met 725 730 735 Ala Ile Glu Leu Lys Lys Arg Ile Glu Gly Tyr Phe Asn Ser Asp Arg 740 745 750 Pro Glu Gly Cys Ala Ala Val Gin Val Asn Ala Tyr Ser Gly Arg Leu 755 760 765 Thr Ala Cys Ala Arg Arg Ala Ala His Val Asp Lys Arg Val Arg Leu 770 775 780 Ile Arg Leu Lys Gly Asp Asp Gly His His Lys Asn Arg Phe Asp Arg 785 790 795 800 Arg Asn His Ala Met Asp Ala Leu Val Ile Ala Leu Met Thr Pro Ala 805 810 815 Ile Ala Arg Thr Ile Ala Val Arg Glu Asp Arg Arg Glu Ala Gin Gin 820 825 830 Leu Thr Arg Ala Phe Glu Ser Trp Lys Asn Phe Leu Gly Ser Glu Glu 835 840 845 Arg Met Gin Asp Arg Trp Glu Ser Trp Ile Gly Asp Val Glu Tyr Ala 850 855 860 Cys Asp Arg Leu Asn Glu Leu Ile Asp Ala Asp Lys Ile Pro Val Thr 865 870 875 880 Glu Asn Leu Arg Leu Arg Asn Ser Gly Lys Leu His Ala Asp Gin Pro 885 890 895 Page 1419 of 3790 Val Ala Glu Cys Val Glu Lys Ile Met Lys Lys Thr Gly Trp Val Asn Leu Pro Ala Lys Ser Thr Ala Gly Asp 160 Leu Lys Asp Arg Val Thr Lys Val Ser Gly Val Ile Phe Asp Glu Asp Page 1422 of 3790 Pro Ser Ala Glu Thr Val Arg Gin Phe Leu Ser Ser Pro Asp Glu Gin 420 425 430 Ser Gin Glu Lys Ile Asp Lys Ile Ser Leu Pro Lys Gly Arg Ala Ala 435 440 445 Tyr Ser Val Asn Ser Leu Glu Arg Leu Thr Arg Arg Met Leu Lys Asp 450 455 460 Ser Val Asp Leu Phe Glu Ala Arg Lys Arg Glu Phe Gly Val Asp Asn 465 470 475 480 Asn Trp Thr Pro Thr Pro Asp Ser Ile Gly Glu Pro Val Gly Asn Pro 485 490 495 Ala Val Asp Arg Val Leu Lys Ile Val Asn Arg Trp Leu Leu Ala Val 500 505 510 Thr Arg Lys Trp Gly Pro Pro Lys Val Val Asn Ile Glu His Val Arg 515 520 525 Val Gly Phe Thr Ser Ala Ala Gin Thr Arg Lys Tyr Glu Glu Glu Asn 530 535 540 Lys Thr Asn Arg Glu Arg Asn Leu Ala Ile Leu Glu Glu Leu Arg Asp 545 550 555 560 Lys Phe Gly Thr Ser Gly Lys Ile Arg Arg Glu Asp Ile Thr Arg Phe 565 570 575 Ala Ala Leu Arg Arg Gin Asn Cys Gin Cys Ala Tyr Cys Gly Glu Ala 580 585 590 Ile Thr Phe Phe Asp Cys Glu Met Asp His Ile Val Pro Arg Lys Gly 595 600 605 Pro Gly Ser Thr Asn Thr Arg Asn Asn Leu Val Ala Ile Cys Glu Arg 610 615 620 Cys Asn Lys Ser Lys Ser Asn Met Pro Phe Ser Leu Trp Ala Gin Asn 625 630 635 640 Cys Asp Ile Pro Gly Val Ser Val Glu Ala Val Ile Asp Arg Val Arg 645 650 655 Thr Trp Ile Lys Asp Pro Glu Leu Asn Pro Lys Gin Tyr Asn Asn Phe 660 665 670 Page 1423 of 3790 Lys Lys Asp Val Ile Glu Arg Leu Arg Lys Thr Val Asp Asp Asp Ala 675 680 685 Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Thr Glu Leu 690 695 700 Ala Asp Arg Ile Gly Ser His Phe Arg Thr Ala Gly Ala Asn Thr Lys 705 710 715 720 Val Arg Val Tyr Arg Gly Trp Leu Thr Ser Glu Ala Arg Lys Ala Ser 725 730 735 Gly Phe Glu Gly Lys Ile Asn Leu Ile Gly Gly Arg Gly Lys Thr Arg 740 745 750 Leu Asp Arg Arg His His Ala Met Asp Ala Ala Thr Ile Ala Leu Met 755 760 765 Arg Gin Ser Val Ala Gin Thr Leu Val Glu Arg Ala Ser Ile Arg Glu 770 775 780 Ser Asp Arg Leu Arg Arg Val Val Ser Ser Ser Trp Lys Asp Tyr Arg 785 790 795 800 Gly Ala Asp Arg Asp Lys Gin Phe Ser Tyr Gly Ser Trp Leu Asn Ser 805 810 815 Met Asn Ala Leu Ala Glu Leu Phe Asn Arg Ala Ile Asp Ala Asp Gly 820 825 830 Ile Pro Val Thr Gin Asn Leu Arg Leu Arg Leu Gly Asn Gly Glu Ala 835 840 845 His Asp Ala Thr Ile Arg Ser Leu Glu Lys Lys Arg Val Gly Ala Ser 850 855 860 Trp Thr Ile Gly Glu Ile Asp Arg Ala Ser Thr Pro Gin Leu Trp Leu 865 870 875 880 Ala Leu Thr Arg Gin Glu Asp Phe Asp Gin Asn Asp Gly Leu Pro Ala 885 890 895 Asn Ala Ser Arg Glu Leu Arg Val Lys Asn His Trp Phe His Ala Glu 900 905 910 Glu Asn Val Thr Leu Phe Pro Thr Lys Ser Ala Ala Ile Ala Val Arg 915 920 925 Page 1424 of 3790 1115 1120 805 1095 PRT Actinomyces sp. 805 Met Pro Ala His His Leu Arg Val Gly Ile Asp Val Gly Thr His Ser 15 10 15 Page 1425 of 3790 Val Gly Leu Ala Thr Leu Arg Val Asp Asp Gin Gly Thr Pro Ile Glu 20 25 30 Leu Leu Ser Ala Leu Ser His Ile His Asp Ser Gly Ile Gly Lys Glu 35 40 45 Gly Gin Lys Asp His Asp Thr Arg Lys Lys Leu Ser Gly Val Ala Arg 50 55 60 Arg Thr Arg His Leu Leu Arg Asn Arg Arg Glu Arg Leu Gin Gin Leu 65 70 75 80 Asp Lys Val Leu Val Asp Leu Gly Phe Pro Ile Pro Lys Pro Glu Glu 85 90 95 Tyr Pro Asp Leu Ser Glu Arg Thr Asp Pro Tyr Arg Val Trp Arg Val 100 105 110 Arg Ala Arg Leu Val Glu Glu Thr Leu Pro Glu Glu Leu Arg Gly Pro 115 120 125 Ala Ile Ser Met Ala Val Arg His Ile Ala Arg His Arg Gly Trp Arg 130 135 140 Asn Pro Tyr Ser Lys Val Glu Ser Leu Leu Ser Pro Ala Glu Glu Ser 145 150 155 160 Ser Phe Met Lys Ala Leu Arg Lys Arg Ile Met Thr Lys Thr Gly Glu 165 170 175 Val Leu Asp Asp Asp Ile Thr Pro Gly Gin Ala Met Ala Gin Val Ala 180 185 190 Leu Thr His Lys Ile Tyr Met Arg Gly Pro Glu Gly Ile Leu Gly Lys 195 200 205 Leu His Gin Ser Asp Asn Ala Asn Glu Ile Arg Lys Ile Cys Ala Arg 210 215 220 Gin Gly Ile Ser Ser Asp Val Cys Lys Gin Leu Leu Arg Ala Val Phe 225 230 235 240 Lys Ala Glu Ser Pro Arg Gly Ser Ala Val Ser Arg Val Ala Pro Asp 245 250 255 Pro Leu Pro Gly Gin Gly Ser Phe Arg Arg Ala Pro Lys Cys Asp Pro 485 490 495 His Val Glu His Val Arg Asp Gly Phe Thr Ser Glu Arg Thr Ala Glu 500 505 510 Page 1427 of 3790 Glu Arg Asp Lys Ala Asn Arg Ser Arg His Asn Asp Asn Gin Lys Ala 515 520 525 Ile Glu Lys Ile Gin His Asp Tyr Gly Lys Glu Gly Tyr Ile Ser Arg 530 535 540 Gly Asp Ile Val Arg Phe His Ala Leu Lys Leu Gin Gly Ser Ala Cys 545 550 555 560 Leu Tyr Cys Gly Thr Thr Ile Gly Tyr His Thr Cys Gin Leu Asp His 565 570 575 Ile Val Pro Gin Ala Gly Pro Gly Ser Asn Asn Arg Arg Gly Asn Leu 580 585 590 Val Ala Val Cys Glu Arg Cys Asn His Ser Lys Ser Asn Thr Pro Phe 595 600 605 Ala Val Trp Ala Gin Lys Cys Gly Ile Pro His Val Gly Val Lys Glu 610 615 620 Ala Ile Ser Arg Val Asn Gly Trp Val Glu His Asn His Ser Thr Ser 625 630 635 640 Ser Gly Asp Leu Thr Arg Leu Lys Lys Glu Val Ile Ala Arg Leu Arg 645 650 655 Arg Thr Gin Lys Asp Pro Glu Ile Asp Glu Arg Ser Met Glu Ser Val 660 665 670 Ala Trp Met Ala Asn Glu Leu His His Arg Ile Ala Ala Ala Tyr Pro 675 680 685 Glu Thr Thr Val Met Val Tyr Arg Gly Ser Ile Thr Ala Ala Ala Arg 690 695 700 Lys Ala Ala Ser Ile Glu Ser Arg Ile Asn Leu Ile Gly Glu Lys Gly 705 710 715 720 Arg Lys Asp Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val 725 730 735 Val Ala Leu Met Glu Pro Ser Val Ala Lys Thr Leu Ala Glu Arg Ser 740 745 750 Ser Leu Arg Gly Glu Gin Arg Leu Thr Gly Gin Glu Gin Thr Trp Lys 755 760 765 Page 1428 of 3790 Page 1429 of 3790 806 1144 PRT Actinomyces sp. 806 Page 1430 of 3790 His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Glu Thr Leu Leu Gin 145 150 155 160 Pro Ser Glu Pro Ser Asp Phe Leu Lys Gly Leu Asn Asp Arg Ile Ser 165 170 175 Glu Glu Leu Gly Arg Ala Phe Pro Ala Asp Ala Thr Pro Gly Gin Leu 180 185 190 Val Asp Thr Tyr Leu Ala His Pro Asp Tyr Val Gly Arg Ala Gly Thr 195 200 205 Pro Lys Leu Arg Gly Pro Gin Gly Ile Leu Ala Gly Lys Leu His Gin 210 215 220 Ser Asp Asn Ala Gin Glu Ile Arg Gly Ile Cys Asp Val Gin Arg Ile 225 230 235 240 Glu Pro Ala Glu Arg Asp Arg Leu Ile Arg Val Val Phe Glu Ala Lys 245 250 255 Ser Pro Lys Gly Ser Ala Lys Glu Arg Gly Leu Val Gly Tyr Asp Glu 260 265 270 Leu Pro Gly Gin Gly Arg His Val Arg Ala Glu Lys Ala His Pro Ala 275 280 285 Phe Gin Leu Phe Arg Met Val Ser Val Leu Ala Asn Leu Arg Ile Arg 290 295 300 Glu Gly Arg Glu Glu Arg Pro Leu Thr Pro Asp Glu Leu Glu Asp Leu 305 310 315 320 Val Asp Phe Ile Asn Gin Val Ser Leu Lys Gin Glu Val Thr Trp Gin 325 330 335 Asp Leu Ala Asp Lys Leu Arg Ile Glu Arg Ala Asp Leu Arg Gly Thr 340 345 350 Ala Lys Ala Ser Phe Asp Gly Ser Pro Val Leu Arg Asn Pro Pro Thr 355 360 365 Asp Val Thr Thr Glu Lys Ile Met Ala Cys Lys Val Lys Trp Leu Lys 370 375 380 Glu Trp Trp Lys Glu Ala Asp Asp Glu Gin Arg Gly Tyr Met Val Asp Page 1432 of 3790 Gin Gly Val Ser Leu Thr Gly Ala Leu Glu Arg Val Asn Met Trp Gin 645 650 655 Arg Asp Ser Gly Met Ser Pro Arg Gin Leu Lys Gin Leu Gin Arg Glu 660 665 670 Val Cys Ala Arg Leu Lys Ser Lys Lys Pro Asp Gin Glu Phe Asp Gly 675 680 685 Arg Ser Met Glu Ser Val Ala Trp Met Ala Val Glu Leu Arg Thr Arg 690 695 700 Ile Glu Gly Phe Tyr Arg Ser Arg Asp Glu Glu Ser Val Pro Ser Val 705 710 715 720 Gly Val Tyr Arg Gly Gin Leu Thr Ala Glu Ala Arg Arg Ala Ser Gly 725 730 735 Phe Glu Ser Arg Val Asn Leu Ile Gly Gly Arg Gly Lys Thr Arg Phe 740 745 750 Asp Arg Arg His His Ala Met Asp Ala Leu Val Ile Ala Leu Met Asn 755 760 765 Pro Ser Val Ser Arg Thr Leu Ala Leu Arg Leu Asn Met Arg Asp Ala 770 775 780 Gin Arg Leu Thr Gly Val Glu Glu Thr Trp Lys His Phe Tyr Gly Lys 785 790 795 800 Pro Gly Glu Ala Ser Lys Arg Phe Glu Ser Trp Arg Glu Ser Met Leu 805 810 815 Arg Gly Val Glu Leu Phe Asn Ile Ala Leu Ser Asp Asn Ala Ile Pro 820 825 830 Phe Val Glu Asn Ile Arg Leu Arg Val Gly Ser Ser Val Ile His Asp 835 840 845 Ala Thr Val His Ser Phe Cys Pro Pro Lys Thr Pro Asp Gly Lys Gin 850 855 860 Ile Ile Thr Lys Gly Tyr Gly Glu Gin His Ser Leu Gly Ser Ala Met 865 870 875 880 Pro Val Glu Leu Ile Asp Arg Ala Glu Thr Pro Ala Leu Trp Thr Ala 885 890 895 Page 1433 of 3790 Page 1434 of 3790 Glu 807 1103 PRT Actinomyces sp. 807 Page 1435 of 3790 Ile Leu Ser Gly Lys Leu His Gin Phe Asp Asn Val Gly Glu Ile Arg 210 215 220 Lys Ile Cys Glu Val Gin Arg Leu Asp His Asp Val Phe Lys Leu Leu 225 230 235 240 Val Arg Lys Val Phe Phe Ala Lys Ser Pro Arg Gly Ser Ala Ala Gly 245 250 255 Leu Val Gly His Asp Gin Ile Pro Gly Gin Gly Lys Tyr Ile Arg Ala 260 265 270 Glu Lys Ala His Pro Asp Phe Gin Leu Phe Arg Ile Val Ala Val Leu 275 280 285 Thr Asn Leu Arg Ile Arg Glu Gly Lys Ala Glu Arg Cys Leu Thr Pro 290 295 300 Asp Glu Leu Arg Gly Leu Val Asp Tyr Ile Leu Glu Val Gin Leu Lys 305 310 315 320 Gin Gin Val Thr Trp Ala Asp Leu Ala Asp Asn Leu Gly Ile Glu Arg 325 330 335 Thr Asp Leu Arg Gly Thr Ala Arg Ala Ser Phe Asp Gly Ser Pro Ala 340 345 350 Leu Arg Phe Pro Pro Thr Asp Val Thr Ala Glu Lys Ile Met Ala Ser 355 360 365 Lys Val Lys Trp Leu Lys Asp Trp Trp Asp Lys Ala Asp Ser Glu Arg 370 375 380 Arg Gly Phe Met Val Asp Ala Leu Ser Asn Ser Gly Gly Ser Thr Gly 385 390 395 400 Asp Asn Asp Ile Asp Asp Glu Val Ala Ala Leu Leu Glu Ala Ala Thr 405 410 415 Glu Asp Glu Gin Ala Glu Leu Glu Lys Ile Gin Leu Pro Gin Gly Arg 420 425 430 Ala Ala Tyr Ser Leu Asp Ser Leu Arg Arg Leu Thr Lys Arg Met Leu 435 440 445 Glu Glu Gly Val Asp Leu His Thr Ala Arg Lys Glu Glu Phe Asn Val Page 1437 of 3790 Asp Ser Val Pro Lys Val Gly Ile Tyr Arg Gly Gin Leu Thr Ala Glu 705 710 715 720 Ala Arg Lys Ala Ser Gly Phe Glu Asn Arg Val Asn Leu Ile Gly Gly 725 730 735 Lys Gly Lys Thr Arg Phe Asp Arg Arg His His Ala Met Asp Ala Leu 740 745 750 Val Ile Ala Met Met Asn Gin Ser Val Ser Gin Thr Leu Ala Leu Arg 755 760 765 Val Asn Met Arg Glu Ser Gin Arg Ile Thr Gly Gin Glu Glu Thr Trp 770 775 780 Lys Asn Phe Tyr Gly Lys Pro Gly Gin Ala Ser Glu Arg Phe Glu Lys 785 790 795 800 Trp Arg Glu Gly Met Leu Arg Ala Val Glu Leu Phe Asn Ile Glu Leu 805 810 815 Ala Lys Asn Ala Ile Pro Phe His Glu Asn Val Arg Leu Arg Val Gly 820 825 830 Ser Ser Lys Val His Asp Asp Thr Val Arg Lys Phe Ile His Ala Lys 835 840 845 Leu Gly Glu Ala Leu Ser Val Ala Met Ile Asp Cys Ala Glu Thr Pro 850 855 860 Ala Leu Trp Thr Ala Leu Thr Arg Leu Pro Asp Phe Asp Pro Lys Asp 865 870 875 880 Gly Leu Pro Glu Asp Leu Ser Arg Glu Ile Tyr Ile His Ser Arg Lys 885 890 895 Ile Thr Ala Asp Glu Gin Leu Asn Phe Phe Asn Ser Pro Ser Ala Cys 900 905 910 Leu Lys Val Arg Gly Gly Tyr Val Glu Ile Gly Ser Ser Ile His His 915 920 925 Ala Arg Val Tyr Arg Ile Asp Gly Lys Lys Thr Thr Tyr Ser Met Val 930 935 940 Arg Val Phe Ala Thr Asp Leu Val Lys Met Thr His Glu Asp Val Phe 945 950 955 960 Page 1438 of 3790 Thr Thr Pro Leu Lys Pro Ser Thr 965 Lys Ile Arg Lys Ala Leu Ala Asp 980 Leu Val Glu Gly Asp Glu Leu Gin 995 1000 Ile Ser Met Arg Thr Ala Asp Pro 970 975 Gly Thr Ala Thr Gin Ile Gly Trp 985 990 Leu Glu Thr Asp Lys Tyr Ser Gly 808 1114 PRT Actinomyces turicensis 808 Met Gin Phe His Phe Tyr Met Val Tyr Val Thr Met Lys Gly Met Asn 15 10 15 Asp Lys Asp Ala Ser Gin Gin Leu Arg Tyr Arg Val Gly 20 25 Ile Asp Val 30 Gly Thr His 35 Ser Ile Gly Phe Cys Ala Val 40 Glu Val Asp Glu 45 Ser Gly Met Pro Ile Gin Leu Leu Asn Ser Met Val His Lys His Asp Ser Gly 50 55 60 Page 1439 of 3790 Ile Asp Pro Gly Gly Asn Asp Thr Ala Thr Thr Arg Leu Ala Glu Ala 65 70 75 80 Gly Val Ala Arg Arg Thr Arg Arg Leu Ile Arg Arg Arg Lys Lys Arg 85 90 95 Leu Gin Glu Leu Asp Ala Phe Ile Glu Glu Cys Gly Trp Pro Leu Val 100 105 110 Asp Leu Ala Thr Ile Thr Asp Ala Arg Ser Pro Trp Arg Ile Arg Ala 115 120 125 His Leu Ala Thr Glu His Ile Asp Asp Glu Ala Glu Gin Gly Lys Leu 130 135 140 Leu Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Ser 145 150 155 160 Pro Tyr Ala Arg Ile Ser Ser Leu His Ile Gin Ala Asp Pro Ser Glu 165 170 175 Gin Leu Lys Ala Leu Ala Gin Arg Val Ser Glu Lys Thr Gly Ile Ser 180 185 190 Leu Thr Ala Asp Gin Thr Pro Ala Gin Leu Ile Ser Val Tyr Leu Asp 195 200 205 Val Phe Glu Thr Gly Lys Leu Arg Gly Pro Glu Gly Ile Leu Gly Gly 210 215 220 Lys Leu Met Gin Ser Asp Asn Ala Asn Glu Leu Arg Arg Ile Ala Thr 225 230 235 240 Val Gin Gly Leu Asp Asn Asp Leu Leu Lys Lys Ile Ile Gly Phe Val 245 250 255 Phe Ala Ala Glu Ser Pro Lys Gly Ser Ala Ala Lys Arg Val Gly Lys 260 265 270 Asp Val Leu Pro Gly Ala His Gly Leu Arg Ala Glu Lys Ala His Pro 275 280 285 Ala Phe Gin Gin Phe Arg Ile Val Ser Ile Val Gin Asn Leu Arg Ile 290 295 300 Lys Glu Gly Thr Gly Leu Arg Ala Leu Thr Ser Glu Glu Thr Glu Ile 305 310 315 320 Page 1440 of 3790 Val Val Asp Phe Leu Asn Gin Ala Gly Leu Thr Glu Ala Pro Thr Trp 325 330 335 Glu Glu Val Ala Asp Asn Leu Glu Ile Pro Arg Ser His Leu Lys Gly 340 345 350 Thr Ala Thr Glu Gly Phe Asp Gly Ile Ala Pro Ser Thr Arg Pro Pro 355 360 365 Phe Asp Val Thr Ser Gin Lys Ile Leu Asn Gly Lys Leu Lys Lys Leu 370 375 380 Ser Ala Trp Trp Lys Asp Ala Asp Tyr Asp His Arg Cys Ala Met Val 385 390 395 400 Asn Ala Leu Ser Asn Val Gly Ser Asp Asp Glu Gly Ser Leu Ala Asp 405 410 415 Asp Asp Val Arg Glu Phe Leu Ser Asp Phe Thr Asp Glu Glu Leu Glu 420 425 430 Ala Leu Asp Lys Val Glu Leu Pro Gly Gly Arg Ala Ala Tyr Ser Val 435 440 445 Asp Ser Leu Glu Lys Leu Thr Asn Thr Met Leu Ser Glu Gly Cys Asp 450 455 460 Leu His Ser Ala Arg Lys Ile Ala Phe Gly Val Asp Asp Ser Trp Thr 465 470 475 480 Pro Pro Ala Glu Pro Ile Gly Gin Pro Val Gly Asn Pro Ala Val Asp 485 490 495 Arg Val Leu Lys Gin Val Ala Arg Trp Ile Ser Ala Ala Thr Asn Gin 500 505 510 Trp Gly Thr Pro Glu Ser Val Asn Ile Glu His Val Arg Asp Ala Leu 515 520 525 Gly Ser Glu Lys Ala Ser Arg Glu Tyr Gin Arg Ser Leu Gin Thr Arg 530 535 540 Arg Ile Arg Asn Glu Lys Leu Phe Ala Glu Met Arg Glu Arg Leu Asp 545 550 555 560 Ile Gly Gly Lys Pro Arg Arg Ser Glu Leu Thr Arg Tyr Leu Ala Leu Page 1442 of 3790 Ala Ser Glu Gly Leu Ala Asp Asp Val Pro Asp Asp Ile Val Lys 1055 1060 1065 Page 1443 of 3790 Gin 809 1113 PRT Alcanivorax sp. 809 Met Arg Tyr Arg Val Gly Leu Asp Leu Gly Thr Ala Ser Val Gly Ala 15 10 15 Ala Val Phe Ser Met Asp Glu Gin Gly Asn Pro Met Glu Leu Ile Trp 20 25 30 His Tyr Glu Arg Leu Phe Ser Glu Pro Leu Val Pro Asp Met Gly Gin 35 40 45 Leu Lys Pro Lys Lys Ala Ala Arg Arg Leu Ala Arg Gin Gin Arg Arg 50 55 60 Gin Ile Asp Arg Arg Ala Ser Arg Leu Arg Arg Ile Ala Ile Val Ser 65 70 75 80 Arg Arg Leu Gly Ile Ala Pro Gly Arg Asn Asp Ser Gly Val His Gly 85 90 95 Asn Asp Val Pro Thr Leu Arg Ala Met Ala Val Asn Glu Arg Ile Glu 100 105 110 Leu Gly Gin Leu Arg Ala Val Leu Leu Arg Met Gly Lys Lys Arg Gly 115 120 125 Tyr Gly Gly Thr Phe Lys Ala Val Arg Lys Val Gly Glu Ala Gly Glu 130 135 140 Val Ala Ser Gly Ala Ser Arg Leu Glu Glu Glu Met Val Ala Leu Ala 145 150 155 160 Page 1444 of 3790 Ser Val Gin Asn Lys Asp Ser Val Thr Val Gly Glu Tyr Leu Ala Ala 165 170 175 Arg Val Glu His Gly Leu Pro Ser Lys Leu Lys Val Ala Ala Asn Asn 180 185 190 Glu Tyr Tyr Ala Pro Glu Tyr Ala Leu Phe Arg Gin Tyr Leu Gly Leu 195 200 205 Pro Ala Ile Lys Gly Arg Pro Asp Cys Leu Pro Asn Met Tyr Ala Leu 210 215 220 Arg His Gin Ile Glu His Glu Phe Glu Arg Ile Trp Ala Thr Gin Ser 225 230 235 240 Gin Phe His Asp Val Met Lys Asp His Gly Val Lys Glu Glu Ile Arg 245 250 255 Asn Ala Ile Phe Phe Gin Arg Pro Leu Lys Ser Pro Ala Asp Lys Val 260 265 270 Gly Arg Cys Ser Leu Gin Thr Asn Leu Pro Arg Ala Pro Arg Ala Gin 275 280 285 Ile Ala Ala Gin Asn Phe Arg Ile Glu Lys Gin Met Ala Asp Leu Arg 290 295 300 Trp Gly Met Gly Arg Arg Ala Glu Met Leu Asn Asp His Gin Lys Ala 305 310 315 320 Val Ile Arg Glu Leu Leu Asn Gin Gin Lys Glu Leu Ser Phe Arg Lys 325 330 335 Ile Tyr Lys Glu Leu Glu Arg Ala Gly Cys Pro Gly Pro Glu Gly Lys 340 345 350 Gly Leu Asn Met Asp Arg Ala Ala Leu Gly Gly Arg Asp Asp Leu Ser 355 360 365 Gly Asn Thr Thr Leu Ala Ala Trp Arg Lys Leu Gly Leu Glu Asp Arg 370 375 380 Trp Gin Glu Leu Asp Glu Val Thr Gin Ile Gin Val Ile Asn Phe Leu 385 390 395 400 Ala Asp Leu Gly Ser Pro Glu Gin Leu Asp Thr Asp Asp Trp Ser Cys 405 410 415 Page 1445 of 3790 Arg Phe Met Gly Lys Asn Gly Arg Pro Arg Asn Phe Ser Asp Glu Phe 420 425 430 Val Ala Phe Met Asn Glu Leu Arg Met Thr Asp Gly Phe Asp Arg Leu 435 440 445 Ser Lys Met Gly Phe Glu Gly Gly Arg Ser Ser Tyr Ser Ile Lys Ala 450 455 460 Leu Lys Ala Leu Thr Glu Trp Met Ile Ala Pro His Trp Arg Glu Thr 465 470 475 480 Pro Glu Thr His Arg Val Asp Glu Glu Ala Ala Ile Arg Glu Cys Tyr 485 490 495 Pro Glu Ser Leu Ala Thr Pro Ala Gin Gly Gly Arg Gin Ser Lys Leu 500 505 510 Glu Pro Pro Pro Leu Thr Gly Asn Glu Val Val Asp Val Ala Leu Arg 515 520 525 Gin Val Arg His Thr Ile Asn Met Met Ile Asp Asp Leu Gly Ser Val 530 535 540 Pro Ala Gin Ile Val Val Glu Met Ala Arg Glu Met Lys Gly Gly Val 545 550 555 560 Thr Arg Arg Asn Asp Ile Glu Lys Gin Asn Lys Arg Phe Ala Ser Glu 565 570 575 Arg Lys Lys Ala Ala Gin Ser Ile Glu Glu Asn Gly Lys Thr Pro Thr 580 585 590 Pro Ala Arg Ile Leu Arg Tyr Gin Leu Trp Ile Glu Gin Gly His Gin 595 600 605 Cys Pro Tyr Cys Glu Ser Asn Ile Ser Leu Glu Gin Ala Leu Ser Gly 610 615 620 Ala Tyr Thr Asn Phe Glu His Ile Leu Pro Arg Thr Leu Thr Gin Ile 625 630 635 640 Gly Arg Lys Arg Ser Glu Leu Val Leu Ala His Arg Glu Cys Asn Asp 645 650 655 Glu Lys Gly Asn Arg Thr Pro Tyr Gin Ala Phe Gly His Asp Asp Arg Page 1447 of 3790 810 1146 PRT Alicyclobacillus hesperidum 810 Met Ala Tyr Arg Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp 15 10 15 Page 1448 of 3790 Ala Val Val Ala Leu Glu Lys Asp Glu Ser Gly Leu Lys Pro Val Arg 20 25 30 Ile Gin Asp Leu Gly Val Arg Ile Phe Asp Lys Ala Glu Asp Ser Lys 35 40 45 Thr Gly Ala Ser Leu Ala Leu Pro Arg Arg Glu Ala Arg Ser Ala Arg 50 55 60 Arg Arg Thr Arg Arg Arg Arg His Arg Leu Trp Arg Val Lys Arg Leu 65 70 75 80 Leu Glu Gin His Gly Ile Leu Ser Met Glu Gin Ile Glu Ala Leu Tyr 85 90 95 Ala Gin Arg Thr Ser Ser Pro Asp Val Tyr Ala Leu Arg Val Ala Gly 100 105 110 Leu Asp Arg Cys Leu Ile Ala Glu Glu Ile Ala Arg Val Leu Ile His 115 120 125 Ile Ala His Arg Arg Gly Phe Gin Ser Asn Arg Lys Ser Glu Ile Lys 130 135 140 Asp Ser Asp Ala Gly Lys Leu Leu Lys Ala Val Gin Glu Asn Glu Asn 145 150 155 160 Leu Met Gin Ser Lys Gly Tyr Arg Thr Val Ala Glu Met Leu Val Ser 165 170 175 Glu Ala Thr Lys Thr Asp Ala Glu Gly Lys Leu Val His Gly Lys Lys 180 185 190 His Gly Tyr Val Ser Asn Val Arg Asn Lys Ala Gly Glu Tyr Arg His 195 200 205 Thr Val Ser Arg Gin Ala Ile Val Asp Glu Val Arg Lys Ile Phe Ala 210 215 220 Ala Gin Arg Ala Leu Gly Asn Asp Val Met Ser Glu Glu Leu Glu Asp 225 230 235 240 Ser Tyr Leu Lys Ile Leu Cys Ser Gin Arg Asn Phe Asp Asp Gly Pro 245 250 255 Gly Gly Asp Ser Pro Tyr Gly His Gly Ser Val Ser Pro Asp Gly Val 260 265 270 Page 1449 of 3790 Arg Gin Ser Ile Tyr Glu Arg Met Val Gly Ser Cys Thr Phe Glu Thr 275 280 285 Gly Glu Lys Arg Ala Pro Arg Ser Ser Tyr Ser Phe Glu Arg Phe Gin 290 295 300 Leu Leu Thr Lys Val Val Asn Leu Arg Ile Tyr Arg Gin Gin Glu Asp 305 310 315 320 Gly Gly Arg Tyr Pro Cys Glu Leu Thr Gin Thr Glu Arg Ala Arg Val 325 330 335 Ile Asp Cys Ala Tyr Glu Gin Thr Lys Ile Thr Tyr Gly Lys Leu Arg 340 345 350 Lys Leu Leu Asp Met Lys Asp Thr Glu Ser Phe Ala Gly Leu Thr Tyr 355 360 365 Gly Leu Asn Arg Ser Arg Asn Lys Thr Glu Asp Thr Val Phe Val Glu 370 375 380 Met Lys Phe Tyr His Glu Val Arg Lys Ala Leu Gin Arg Ala Gly Val 385 390 395 400 Phe Ile Gin Asp Leu Ser Ile Glu Thr Leu Asp Gin Ile Gly Trp Ile 405 410 415 Leu Ser Val Trp Lys Ser Asp Asp Asn Arg Arg Lys Lys Leu Ser Thr 420 425 430 Leu Gly Leu Ser Asp Asn Val Ile Glu Glu Leu Leu Pro Leu Asn Gly 435 440 445 Ser Lys Phe Gly His Leu Ser Leu Lys Ala Ile Arg Lys Ile Leu Pro 450 455 460 Phe Leu Glu Asp Gly Tyr Ser Tyr Asp Val Ala Cys Glu Leu Ala Gly 465 470 475 480 Tyr Gin Phe Gin Gly Lys Thr Glu Tyr Val Lys Gin Arg Leu Leu Pro 485 490 495 Pro Leu Gly Glu Gly Glu Val Thr Asn Pro Val Val Arg Arg Ala Leu 500 505 510 Ser Gin Ala Ile Lys Val Val Asn Ala Val Ile Arg Lys His Gly Ser 515 520 525 Page 1450 of 3790 Pro Glu Ser Ile His Ile Glu Leu Ala Arg Glu Leu Ser Lys Asn Leu 530 535 540 Asp Glu Arg Arg Lys Ile Glu Lys Ala Gin Lys Glu Asn Gin Lys Asn 545 550 555 560 Asn Glu Gin Ile Lys Asp Glu Ile Arg Glu Ile Leu Gly Ser Ala His 565 570 575 Val Thr Gly Arg Asp Ile Val Lys Tyr Lys Leu Phe Lys Gin Gin Gin 580 585 590 Glu Phe Cys Met Tyr Ser Gly Glu Lys Leu Asp Val Thr Arg Leu Phe 595 600 605 Glu Pro Gly Tyr Ala Glu Val Asp His Ile Ile Pro Tyr Gly Ile Ser 610 615 620 Phe Asp Asp Ser Tyr Asp Asn Lys Val Leu Val Lys Thr Glu Gin Asn 625 630 635 640 Arg Gin Lys Gly Asn Arg Thr Pro Leu Glu Tyr Leu Arg Asp Lys Pro 645 650 655 Glu Gin Lys Ala Lys Phe Ile Ala Leu Val Glu Ser Ile Pro Leu Ser 660 665 670 Gin Lys Lys Lys Asn His Leu Leu Met Asp Lys Arg Ala Ile Asp Leu 675 680 685 Glu Gin Glu Gly Phe Arg Glu Arg Asn Leu Ser Asp Thr Arg Tyr Ile 690 695 700 Thr Arg Ala Leu Met Asn His Ile Gin Ala Trp Leu Leu Phe Asp Glu 705 710 715 720 Thr Ala Ser Thr Arg Ser Lys Arg Val Val Cys Val Asn Gly Ala Val 725 730 735 Thr Ala Tyr Met Arg Ala Arg Trp Gly Leu Thr Lys Asp Arg Asp Ala 740 745 750 Gly Asp Lys His His Ala Ala Asp Ala Val Val Val Ala Cys Ile Gly 755 760 765 Asp Ser Leu Ile Gin Arg Val Thr Lys Tyr Asp Lys Phe Lys Arg Asn 980 985 990 Ile Ala Glu Asn Gly Gly Met 995 Val Arg Ile Asp Val Phe Ala Lys Gly 1000 1005 Gly Lys 1010 Tyr Tyr Phe Val Pro 1015 Ile Tyr Val Ala Asp Val Leu Lys 1020 Page 1452 of 3790 Lys Met Asn 1145 811 1552 PRT Anaerophaga sp. 811 Met Phe Ser Gin Arg Asn Asn Pro Tyr Cys Glu Leu Leu Gin Asn Val 15 10 15 Lys Gin Leu Tyr Lys Glu Lys Phe Gly Lys Thr Asn Gin Val Asp Asn 20 25 30 Ser Ile Ile Tyr Gly Phe Met 35 Lys Arg 40 Ile Leu Gly Leu Asp Leu Gly 45 Thr Asn Ser 50 Ile Gly Trp Ala 55 Leu Val Glu Asn Asp 60 Glu Asn Asp Arg Lys Gly Lys Ile Ile Gly Met Gly Ser Arg Ile Ile Pro Met Asp Met 65 70 75 80 Page 1453 of 3790 Ser Glu Leu Asp Asn Phe Asn Lys Gly Ala Ser Ile Ser Lys Thr Ala 85 90 95 Glu Arg Thr Arg Leu Arg Met Thr Arg Arg Leu Arg Glu Arg His Leu 100 105 110 Leu Arg Arg Ala Arg Leu His Arg Ile Leu Asn Ile Met Gly Phe Leu 115 120 125 Pro Glu His Tyr Arg Asn Ser Ile Asp Phe Ile Asp Lys Lys Gly Cys 130 135 140 Phe Phe Glu Gly Gin Glu Pro Lys Ile Ala Tyr Lys Pro Asp Lys Asn 145 150 155 160 Ser Glu Gin Phe Cys Phe Leu Phe Thr Ser Ser Phe His Glu Met Leu 165 170 175 Glu Asp Phe Arg Lys Phe Gin Pro Glu Leu Ile Gin Asn Arg Lys Lys 180 185 190 Val Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr 195 200 205 Gin Lys Ile Ser Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn 210 215 220 Thr Lys Arg Gly Tyr Tyr His Leu Arg Gly Glu Asp Glu Asp Asn Gin 225 230 235 240 Asp Asn Lys Lys Ile Lys Glu Phe Arg Ala Leu Lys Val Val Asn Val 245 250 255 Thr Glu Arg Glu Gly Ala Asn Ser Ser Gly Lys Lys Trp Tyr Asp Met 260 265 270 Glu Leu Glu Asn Gly Trp Val Tyr Ser Arg Gin Ser Asn Leu Pro Pro 275 280 285 Asn Leu Glu Gly Lys Thr Ile Glu Leu Ile Val Ser Tyr Thr Leu Asp 290 295 300 Asn Asn Gly Asn Ile Lys Lys Asp Lys Asn Gly Lys Glu Lys Tyr Ser 305 310 315 320 Leu Ser Met Pro Gly Glu Glu Asp Trp Asn Leu Val Lys Ile Lys Thr 325 330 335 Page 1454 of 3790 Glu Asn Asp Leu Lys Thr Ser Lys Lys Ser Val Gly Glu Tyr Ile Tyr 340 345 350 Asp His Leu Leu Lys Asn Pro Asp Gin Lys Ile Arg Gly Lys Leu Ile 355 360 365 Ser Thr Ile Glu Arg Lys Phe Tyr Lys Glu Glu Leu Ser Arg Ile Leu 370 375 380 Lys Thr Gin Met Asn Phe Tyr Glu Glu Leu Lys Asn Arg Glu Leu Tyr 385 390 395 400 Gin Lys Cys Val Glu Glu Leu Tyr Pro Asn Asn Lys Ser His Gin Gin 405 410 415 Thr Leu Leu Gin Lys Asp Phe Ile His Leu Ile Val Glu Asp Ile Ile 420 425 430 Phe Tyr Gin Arg Pro Leu Lys Ser Lys Arg Ala Phe Val Asn Asn Cys 435 440 445 Pro Leu Glu Tyr Arg Val Tyr Val Asp Lys Lys Ser Gly Glu Leu Ile 450 455 460 Lys Ser Gly Val Lys Cys Ile Pro Lys Ser His Pro Leu Phe Gin Glu 465 470 475 480 Phe Arg Leu Trp Gin Tyr Val Arg Asn Leu Arg Ile Tyr Glu Arg Glu 485 490 495 Arg Met Val Asn Gly Arg Leu Met Val Asn Val Asp Val Thr Asn Glu 500 505 510 Leu Leu Pro Asp Glu Glu His Ile Val Arg Leu Phe Asp Leu Leu Asn 515 520 525 Asp Arg Lys Ser Phe Lys Gin Asp Asp Val Leu Arg Phe Val Gly Ile 530 535 540 Lys Ser Pro Lys Asp Arg Lys Arg Tyr Ser Trp Asn Tyr Pro Glu Asp 545 550 555 560 Lys Glu Leu Pro Gly Asn Glu Thr Arg His Leu Ile Leu Ala Trp Leu 565 570 575 Lys Lys Val Asp Gly Val Pro Glu Asp Trp Leu Asp Pro Glu Lys Leu 580 585 590 Page 1455 of 3790 Lys Ala Leu Trp His Leu Leu Tyr Ser Val Thr Asp Arg Glu Glu Ile 595 600 605 Ile Lys Gly Leu His Ser Phe Ala Lys Lys Tyr Glu Leu Pro Asp Thr 610 615 620 Phe Val Glu His Phe Lys Lys Ile Pro Arg Leu Glu Arg Glu Tyr Gly 625 630 635 640 Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Met 645 650 655 Gly Lys Tyr Trp Lys Ala Glu Glu Ile Pro Ala Asp Leu Leu Glu Lys 660 665 670 Ala Gin Lys Ile Ile Asp Ala Glu Ala Asp Asp Arg Ile Ser Asp Glu 675 680 685 Val Arg Glu Lys Leu Leu His Leu Lys Asp Ile Ser Gin Leu Lys Gly 690 695 700 Leu Pro Leu Trp Gin Ala Ser Tyr Leu Val Tyr Gly Arg His Ser Glu 705 710 715 720 Thr Gly Glu Val Val Lys Trp Arg Thr Ser Glu Asp Leu Glu Lys Tyr 725 730 735 Ile Leu Gin Phe Lys Gin His Ser Leu Arg Asn Pro Val Val Glu Gin 740 745 750 Val Ile Leu Glu Ala Leu Arg Val Val Lys Asp Ile Trp Glu His Tyr 755 760 765 Gly Glu Gly Lys Glu Gly Phe Phe Asn Glu Ile His Val Glu Ile Gly 770 775 780 Arg Glu Leu Lys Asn Pro Ala Asp Lys Arg Lys Lys Ile Thr Ser Gin 785 790 795 800 Ile Gin Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Glu 805 810 815 Glu Leu Phe Asn Asp Pro Ser Val Lys Asn Val Arg Pro Tyr Ser Pro 820 825 830 Ala Gin Gin Glu Ile Leu Arg Ile Tyr Glu Asp Gly Val Leu Asn Gly Page 1456 of 3790 Page 1458 of 3790 Lys Ile Glu Lys 1550 Page 1459 of 3790 812 1515 PRT Anaerophaga thermohalophila 812 Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Glu Ser Asp Glu Glu Gin Lys Ser Gly Lys Ile Gin Gly 20 25 30 Ile Gly Ser Arg Ile Ile Pro Met Asp Gin Asn Glu Leu Asp Asn Phe 35 40 45 Asn Lys Gly Asn Thr Val Ser Gin Thr Ala Glu Arg Thr Arg Leu Arg 50 55 60 Met Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 His Arg Val Leu Lys Glu Ile Gly Phe Leu Pro Glu His Tyr Leu Glu 85 90 95 Gin Ile Asp Phe Thr Glu Lys Pro Gly Gly Phe Leu Pro Gly Lys Glu 100 105 110 Pro Lys Ile Ala Tyr Lys Pro Asp Asn Phe Lys Asp Lys Tyr Asp Phe 115 120 125 Leu Phe Gin Asp Ser Tyr His Glu Met Leu Ser Asp Phe Gin Asp Lys 130 135 140 Asn Pro Glu Phe Ile Gin Lys Arg Lys Lys Val Pro Gin Asp Trp Thr 145 150 155 160 Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Ala Lys Ile Thr Lys Glu 165 170 175 Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr 180 185 190 Gin Leu Arg Gly Glu Asp Glu Asp Val Ala Lys Asn Thr Lys Lys Glu 195 200 205 Glu Phe His Ala Leu Lys Val Val Lys Val Lys Glu Arg Glu Asp Ser 210 215 220 Page 1460 of 3790 Glu Gly Ala Ser Gly Lys Trp Tyr Asp Ile Glu Leu Glu Asn Gly Trp 225 230 235 240 Val Tyr Pro Arg Gin Ser Asn Ile Arg Pro Asp Trp Glu Gly Lys Ile 245 250 255 Leu Glu Leu Ile Val Thr Tyr Asn Leu Asp Lys Asp Gly Asn Ile Lys 260 265 270 Thr Asp Lys Glu Gly Asn Glu Lys Arg Ser Phe Arg Met Pro Asn Lys 275 280 285 Asp Asp Trp Thr Leu Arg Lys Lys Arg Thr Glu Asn Glu Ile Glu Lys 290 295 300 Ser Gly Lys Thr Val Gly Glu Tyr Ile Tyr Asp Asn Leu Leu Asp Ala 305 310 315 320 Pro Asp Leu Lys Ile Arg Gly Lys Leu Val Ser Thr Ile Glu Arg Lys 325 330 335 Tyr Tyr Arg Ser Glu Leu Glu Gin Ile Leu Thr Ala Gin Lys Lys Tyr 340 345 350 His Pro Glu Leu Ser Asn Ser Glu Leu Phe Asn Lys Cys Ile Ser Asn 355 360 365 Leu Tyr Pro Asn Asn Asp Ile His Arg Lys Ala Leu Leu Ser Lys Asp 370 375 380 Phe Val His Leu Ile Ile Asn Asp Ile Ile Phe Tyr Gin Arg Pro Leu 385 390 395 400 Lys Ser Lys Arg Ser Thr Val Ser Asn Cys Pro Leu Glu Tyr Arg Val 405 410 415 Tyr Val Asp Lys Val Thr Gly Glu Lys Lys Lys Val Pro Leu Lys Cys 420 425 430 Ile Pro Lys Ser His Pro Leu Tyr Gin Glu Phe Arg Leu Trp Gin Tyr 435 440 445 Val Lys Asn Leu Arg Leu Phe Glu Lys Glu Arg Phe Glu Asn Gly Arg 450 455 460 Leu Leu Thr Asn Val Asp Val Thr Glu Gin Phe Leu Pro Asp Glu Asp Page 1462 of 3790 Arg Val Val Lys Asp Val Trp Asn Tyr Phe Gly Glu Gly Arg Glu Lys 725 730 735 Phe Phe Asp Glu Ile His Val Glu Ile Gly Arg Asp Leu Lys Asn Pro 740 745 750 Ala Asp Lys Arg Gin Lys Ile Ala Asn Gin Ile Gin Glu Asn Glu Asn 755 760 765 Thr Asn Leu Arg Ile Lys Ala Leu Leu Val Glu Leu Phe Asn Asp Pro 770 775 780 Glu Val Gin Asn Val Arg Pro Tyr Ser Pro Val Gin Gin Gin Leu Leu 785 790 795 800 Lys Ile Tyr Glu Asp Gly Val Leu Asn Ala Glu Arg Asp Ile Pro Asp 805 810 815 Asp Ile Gin Lys Ile Ser Arg Met Ala Asn Pro Thr Arg Asn Gin Leu 820 825 830 Ile Arg Tyr Lys Leu Trp Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr 835 840 845 Gly Glu Ile Ile Pro Leu Asn Lys Leu Phe Thr Ser Glu Tyr Glu Val 850 855 860 Glu His Ile Ile Pro Arg Ala Arg Tyr Phe Asp Asp Ser Phe Ser Asn 865 870 875 880 Lys Ile Ile Ser Glu Ala Glu Val Asn Arg Lys Lys Asp Arg Met Leu 885 890 895 Ala Phe Glu Phe Ile Lys Lys Leu Gly Gly Ser Thr Ile Asp Leu Asn 900 905 910 Tyr Gly Lys Lys Val Ser Val Leu Thr Val Glu Glu Tyr Gin Gin Phe 915 920 925 Val Lys Asp His Tyr Gly Ile Asn Pro His Ser Arg Leu Lys Met Gin 930 935 940 Lys Leu Leu Met Asp Glu Ile Pro Glu Ser Phe Ile Glu Arg Gin Leu 945 950 955 960 Asn Asp Ser Arg Tyr Ile Ser Lys Met Val Arg Asn Leu Leu Ser Asn 965 970 975 Page 1463 of 3790 Ile Val Arg Glu Glu Asn Glu Asn Ser Pro Val Ala Lys Gin Leu Ile 980 985 990 Thr Cys Ser Gly Ser Ile Thr Asn Thr Leu Lys Gin Glu Trp Gly Leu 995 1000 1005 Page 1464 of 3790 Pro Lys Gin Ile Glu Leu Asp Asn Ser Arg Ile Tyr Lys Met Val Page 1465 of 3790 1445 1450 1455 Asn Asn Phe Glu Leu Arg Asn Glu Leu Asp Ala Arg Trp Asp Leu Leu 325 330 814 1068 PRT Bacillus cereus 814 Ile Phe Asp Lys Ala Glu Asn Pro Lys Asp Gly Lys Ser Leu Ala Ala Page 1467 of 3790 40 45 Pro Arg Arg Asp Ala Arg Ser Thr Arg Arg Thr Leu Arg Arg Lys Lys 50 55 60 His Arg Met Gin Arg Ile Lys Ile Leu Leu Val Lys Gin Gly Leu Leu 65 70 75 80 Phe Lys Thr Glu Leu Asn His Leu Tyr Glu Ser Ala Thr Glu Phe Asp 85 90 95 Val Trp Asn Leu Arg Leu Asp Ala Leu Glu Arg Lys Leu His Pro Lys 100 105 110 Glu Phe Ala Arg Val Leu Ile His Leu Ala Lys Arg Arg Gly Phe Lys 115 120 125 Ser Asn Arg Lys Glu Thr Thr Leu Ser Glu Asn Gly Gin Ile Leu Glu 130 135 140 Ser Ile Ser Glu Asn Gin Gin Ile Met Glu Gin Gin Asn Tyr Arg Thr 145 150 155 160 Val Gly Glu Met Ile Leu Lys Asp Lys Lys Phe Glu Asn His Lys Arg 165 170 175 Asn Lys Asp Gly Thr Tyr Ile Gly Thr Val Thr Arg Gin Gin Leu Gin 180 185 190 Asp Glu Ile Gin Met Ile Phe His Thr Gin Arg Leu Tyr Lys Asn Asp 195 200 205 Tyr Ala Thr Glu Glu Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 210 215 220 Gin Arg Pro Tyr Ala Ser Lys Asp Gin Ile Glu Lys Met Ile Gly Tyr 225 230 235 240 Cys Thr Leu Glu Pro Lys Glu Lys Arg Thr Pro Lys Ala Ser Trp Ser 245 250 255 Phe Gin Tyr Phe Val Ala Leu Gin Thr Ile Asn Asn Leu Arg Leu Ile 260 265 270 Ser Lys Asp Lys Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Gin Ile 275 280 285 Page 1468 of 3790 Met Asn Leu Ala Leu Glu Lys Pro Ile Val Lys Tyr Ile Asp Ile Arg 290 295 300 Lys Leu Leu Ser Ile Pro Asn Asp Phe Gin Phe Asn Ser Leu Ser Tyr 305 310 315 320 Ser Ala Asp Thr Val Asp Thr Thr Leu Glu Asn Lys Arg Cys Ile Glu 325 330 335 Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gin Val Tyr Gly 340 345 350 Lys Asn Thr Pro Asn Leu Leu Pro Ile Asp Tyr Asp Thr Ile Ala Tyr 355 360 365 Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gin 370 375 380 Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Lys Asn Leu Ala Lys 385 390 395 400 Lys Thr Tyr Asp Asp Thr Phe Ile Gin Ala Leu Leu Asn Leu Asn Phe 405 410 415 Thr Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 420 425 430 Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 435 440 445 Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Glu Arg Thr Lys Tyr Leu Pro 450 455 460 Val Ile Pro Gin Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gin 465 470 475 480 Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 485 490 495 Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gin Glu 500 505 510 Arg Lys Glu Ile Asp Ser Arg Tyr Gin Asp Asn Ser Lys Lys Asn Glu 515 520 525 His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 530 535 540 Page 1469 of 3790 Ile Asn Ile Val Lys Phe Lys Leu Trp Ser Glu Gin Asp Gly Arg Cys 545 550 555 560 Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 565 570 575 Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 580 585 590 Ser Tyr Asn Asn Lys Ile Leu Thr Leu Gly Thr Glu Asn Gin Arg Lys 595 600 605 Gly Asn Lys Thr Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asp 610 615 620 Glu Phe Glu Thr Arg Val Gin Ser Asn Lys Lys Ile Asn Phe Lys Lys 625 630 635 640 Gin Gin Lys Leu Leu Leu Gin Asn Phe Ser Tyr Ala Arg Glu Gin Glu 645 650 655 Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 660 665 670 Thr Ser Leu Ile Gin Gin His Leu Ile Phe Ser Glu Ser Ser Ser Lys 675 680 685 Lys Lys Val Arg Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 690 695 700 Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 705 710 715 720 Leu Asp Ala Val Ile Val Ala Val Thr Ser Asn His Met Ile Gin Arg 725 730 735 Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Lys Asn Leu Gin Ala 740 745 750 Lys Gin Leu Pro Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 755 760 765 Glu Ala Arg Ile Ser Pro Asn Thr Gin Gin Tyr Leu Lys Gly Ile His 770 775 780 Phe Lys Asn Tyr Ala Asp Val Asn Leu Ser Asp Ile Lys Pro Ile Phe 785 790 795 800 Page 1470 of 3790 Lys Gin Leu Leu Leu Phe Glu Lys Tyr Gin Val Asp Val Leu Gly Page 1471 of 3790 1040 1045 1050 His Tyr Thr Lys Ile Lys Glu Glu Lys Arg Met Gly Met Ala Ile Asp Glu Ile Gin Met Ile Phe His Ala Gin Arg Leu Tyr Lys Asn Asp Page 1472 of 3790 195 200 205 Tyr Ala Thr Glu Glu Phe Glu Ser Ser Tyr Leu Glu Ile Trp Ala Ser 210 215 220 Gin Arg Pro Tyr Ala Ser Lys Asp Gin Ile Glu Lys Met Ile Gly Tyr 225 230 235 240 Cys Thr Leu Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Ser Trp Ser 245 250 255 Phe Gin Tyr Phe Val Ala Leu Gin Thr Ile Asn Asn Leu Arg Leu Ile 260 265 270 Ser Lys Asp Arg Ile Glu Glu Leu Ser Phe Glu Glu Lys Lys Gin Ile 275 280 285 Met Asn Leu Ala Leu Glu Lys Ser Ile Val Lys Tyr Ile Asp Ile Arg 290 295 300 Lys Leu Leu Ser Val Pro Asn Glu Phe Gin Phe Asn Ser Leu Ser Tyr 305 310 315 320 Ser Ala Asp Thr Val Asp Thr Ala Val Glu Ser Arg Lys Cys Ile Glu 325 330 335 Leu Lys Glu Tyr His Ser Ile Asn Lys Val Tyr Lys Gin Ile Tyr Gly 340 345 350 Glu Asn Ala Leu Asn Leu Leu Pro Lys Tyr Tyr Asp Thr Ile Ala Tyr 355 360 365 Gly Leu Thr Ile Phe Lys Asp Asp Lys Asp Ile Leu Glu Tyr Leu Gin 370 375 380 Asn Lys Tyr Val Asn Ala Lys Gly Lys Pro Ile Ser Asn Phe Ala Asn 385 390 395 400 Lys Thr Tyr Asp Asp Thr Phe Ile Gin Ala Leu Leu Asn Leu Asn Phe 405 410 415 Thr Lys Met Gly His Leu Ser Phe Lys Ala Leu Lys Asn Ile Ile Pro 420 425 430 Phe Leu Glu Glu Gly Leu Ser Tyr Asp Lys Ala Cys Glu Lys Ala Gly 435 440 445 Page 1473 of 3790 Tyr Asn Phe Lys Gly Thr Ser Tyr Thr Glu Gin Thr Lys Tyr Leu Pro 450 455 460 Val Ile Pro Gin Asn Thr Asn Pro Val Val His Arg Ala Leu Ser Gin 465 470 475 480 Thr Arg Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Asn 485 490 495 Ala Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Thr Phe Gin Glu 500 505 510 Arg Lys Glu Ile Asp Ser Met Tyr Gin Asp Asn Ser Lys Lys Asn Glu 515 520 525 His Ala Ile His Lys Leu Lys Glu Leu Gly Asn Ile Asn Pro Ser Gly 530 535 540 Ile Asn Ile Val Lys Phe Lys Leu Trp Asn Glu Gin Asp Gly Arg Cys 545 550 555 560 Met Tyr Ser Gly Lys Tyr Ile Glu Pro His Arg Leu Phe Glu Glu Gly 565 570 575 Tyr Thr Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp Asp 580 585 590 Ser Tyr Asn Asn Lys Thr Leu Thr Leu Gly Thr Glu Asn Gin Arg Lys 595 600 605 Gly Asn Lys Ile Pro Tyr Glu Tyr Met Gly Asn Thr Ser Ile Trp Asn 610 615 620 Asp Phe Glu Thr Arg Val Gin Ser Asn Lys Lys Ile Asn Lys Lys Lys 625 630 635 640 Gin Gin Lys Leu Leu Leu Gin His Phe Ser Tyr Ala Arg Glu Gin Glu 645 650 655 Phe Ile Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Tyr Leu 660 665 670 Ser Ser Leu Ile Gin Gin His Leu Ile Phe Ser Glu Ser Ser Arg Lys 675 680 685 Lys Lys Val His Thr Val Ser Gly Ile Ile Thr Ser His Leu Arg Ser 690 695 700 Page 1474 of 3790 Arg Trp Gly Phe Asn Lys Asp Arg Lys Glu Gly His Ile His His Ala 705 710 715 720 Leu Asp Ala Val Ile Val Ala Val Thr Ser Asp His Met Ile Gin Arg 725 730 735 Val Thr Lys Tyr Tyr Lys Leu Lys Glu Leu Asn Arg Asn Leu Gin Ala 740 745 750 Lys Arg Met Pro Phe Pro Glu Pro Trp Glu Gly Phe Arg Leu Glu Leu 755 760 765 Glu Ala Arg Ile Ser Pro Asn Thr Gin Gin Tyr Leu Lys Gly Leu Arg 770 775 780 Phe Lys Asn Tyr Ala Asp Val Asn Leu Ser Glu Ile Lys Ser Ile Phe 785 790 795 800 Val Ser Arg Met Pro Lys His Ser Ile Thr Gly Glu Leu His Gin Glu 805 810 815 Thr Ile Arg Lys Phe Ile Gly Tyr Asn Glu Lys Gly Lys Val Leu Thr 820 825 830 Ala Ile Lys Thr Lys Leu Glu Asp Ile Pro Phe Asp Ala Asn Gly Asp 835 840 845 Phe Pro Met Tyr Gly Lys Glu Ser Asp Leu Tyr Thr Tyr Asn Ala Ile 850 855 860 Lys Glu Arg Tyr Leu Ser His Lys Lys Asp Lys Arg Lys Ser Phe Gin 865 870 875 880 Glu Pro Leu Tyr Lys Pro Thr Lys Ser Gly Gly Ile Gly Pro Leu Ile 885 890 895 Lys Ser Ile Lys Ile Met Asp Thr Arg Thr Ile Val Asn Pro Val Asn 900 905 910 Gin Gly Lys Gly Val Val Tyr Asn Ser Lys Ile Ala Arg Thr Asp Val 915 920 925 Phe Lys Lys Glu Glu Lys Tyr Tyr Leu Ile Pro Ile Tyr Thr Ile Asp 930 935 940 Leu Met Lys Asn Ile Leu Pro Gin Lys Ala Ile Thr Ala Gly Lys Gly 945 950 955 960 Page 1475 of 3790 816 1088 PRT Bacillus smithii 816 Page 1476 of 3790 Val Trp Gin Leu Arg Val Asp Ala Leu Glu Arg Lys Leu Asn Asn Asp 100 105 110 Glu Leu Ala Arg Val Leu Leu His Leu Ala Lys Arg Arg Gly Phe Lys 115 120 125 Ser Asn Arg Lys Ser Glu Arg Asn Ser Lys Glu Ser Ser Glu Phe Leu 130 135 140 Lys Asn Ile Glu Glu Asn Gin Ser Ile Leu Ala Gin Tyr Arg Ser Val 145 150 155 160 Gly Glu Met Ile Val Lys Asp Ser Lys Phe Ala Tyr His Lys Arg Asn 165 170 175 Lys Leu Asp Ser Tyr Ser Asn Met Ile Ala Arg Asp Asp Leu Glu Arg 180 185 190 Glu Ile Lys Leu Ile Phe Glu Lys Gin Arg Glu Phe Asn Asn Pro Val 195 200 205 Cys Thr Glu Arg Leu Glu Glu Lys Tyr Leu Asn Ile Trp Ser Ser Gin 210 215 220 Arg Pro Phe Ala Ser Lys Glu Asp Ile Glu Lys Lys Val Gly Phe Cys 225 230 235 240 Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 245 250 255 Gin Ser Phe Ile Val Trp Glu His Ile Asn Lys Leu Arg Leu Val Ser 260 265 270 Pro Asp Glu Thr Arg Ala Leu Thr Glu Ile Glu Arg Asn Leu Leu Tyr 275 280 285 Lys Gin Ala Phe Ser Lys Asn Lys Met Thr Tyr Tyr Asp Ile Arg Lys 290 295 300 Leu Leu Asn Leu Ser Asp Asp Ile His Phe Lys Gly Leu Leu Tyr Asp 305 310 315 320 Pro Lys Ser Ser Leu Lys Gin Ile Glu Asn Ile Arg Phe Leu Glu Leu 325 330 335 Asp Ser Tyr His Lys Ile Arg Lys Cys Ile Glu Asn Val Tyr Gly Lys 565 570 575 Gly Tyr Val Glu Val Asp His Ile Leu Pro Tyr Ser Arg Ser Leu Asp 580 585 590 Page 1478 of 3790 Asp Ser Tyr Ala Asn Lys Val Leu Val Leu Thr Lys Glu Asn Arg Glu 595 600 605 Lys Gly Asn His Thr Pro Val Glu Tyr Leu Gly Leu Gly Ser Glu Arg 610 615 620 Trp Lys Lys Phe Glu Lys Phe Val Leu Ala Asn Lys Gin Phe Ser Lys 625 630 635 640 Lys Lys Lys Gin Asn Leu Leu Arg Leu Arg Tyr Glu Glu Thr Glu Glu 645 650 655 Lys Glu Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Lys 660 665 670 Phe Phe Ala Asn Phe Ile Lys Glu His Leu Lys Phe Ala Asp Gly Asp 675 680 685 Gly Gly Gin Lys Val Tyr Thr Ile Asn Gly Lys Ile Thr Ala His Leu 690 695 700 Arg Ser Arg Trp Asp Phe Asn Lys Asn Arg Glu Glu Ser Asp Leu His 705 710 715 720 His Ala Val Asp Ala Val Ile Val Ala Cys Ala Thr Gin Gly Met Ile 725 730 735 Lys Lys Ile Thr Glu Phe Tyr Lys Ala Arg Glu Gin Asn Lys Glu Ser 740 745 750 Ala Lys Lys Lys Glu Pro Ile Phe Pro Gin Pro Trp Pro His Phe Ala 755 760 765 Asp Glu Leu Lys Ala Arg Leu Ser Lys Phe Pro Gin Glu Ser Ile Glu 770 775 780 Ala Phe Ala Leu Gly Asn Tyr Asp Arg Lys Lys Leu Glu Ser Leu Arg 785 790 795 800 Pro Val Phe Val Ser Arg Met Pro Lys Arg Ser Val Thr Gly Ala Ala 805 810 815 His Gin Glu Thr Leu Arg Arg Cys Val Gly Ile Asp Glu Gin Ser Gly 820 825 830 Lys Ile Gin Thr Ala Val Lys Thr Lys Leu Ser Asp Ile Lys Leu Asp 835 840 845 Page 1479 of 3790 Gin Ser Val Ser Asp 1085 Page 1480 of 3790 817 1069 PRT Bacillus thuringiensis 817 Page 1481 of 3790 Arg Pro Thr Leu Thr Tyr Glu Gin Leu Met Ser Met Val Gly Asn Cys 225 230 235 240 Ile Tyr Glu Lys Lys Glu Lys Arg Ala Pro Lys Thr Ser Trp Ala Phe 245 250 255 Gin Tyr Phe Ser Leu Leu Gin Lys Ile Asn Lys Leu Lys Val Ser Asp 260 265 270 Asp Asn Thr Leu Arg Lys Leu Ser Lys Glu Glu Arg Asp Ile Val Ile 275 280 285 Glu Leu Ala Phe Lys Lys Lys Asn Val Ser Phe Val Asp Ile Arg Lys 290 295 300 Ala Leu Lys Leu Asn Asp Asn Thr Lys Phe Asn His Leu Thr Tyr Ser 305 310 315 320 His Val Val Glu Thr Lys Lys Val Glu Lys Ala Thr Phe Ile Glu Leu 325 330 335 Lys Gly Tyr His Leu Ile Lys Lys Gin Leu Lys Asp Arg Asn Val Glu 340 345 350 Leu Thr Gin Glu Leu Gin Pro Lys Asp Tyr Asp Ala Ile Ala Ala Ala 355 360 365 Ser Thr Phe Phe Lys Asn Asp Ile Glu Phe Arg Asp Tyr Leu Arg Asn 370 375 380 Gin Tyr Leu Asp Ser Asn Gly Lys Arg Lys Ser Asn Ile Ala Asn Lys 385 390 395 400 Val Phe Glu Asp Lys Val Ile Ala Ala Val Phe Glu Leu Asn Phe Ser 405 410 415 Lys Val Cys His Leu Ser Phe Lys Ser Leu Tyr Lys Leu Ile Pro His 420 425 430 Leu Glu Lys Gly Leu Asp Tyr Lys Glu Ala Ile Leu Cys Ala Gly Tyr 435 440 445 Asn Phe Arg Asp Glu Asn Lys Arg Asp Lys Lys Leu Phe Leu Pro Val 450 455 460 Ile Gin Gin Glu Thr Asn Pro Val Val His Arg Ala Leu Thr Gin Ala Page 1483 of 3790 Val Asp Ala Ala Ile Val Ala Val Leu Thr Asp Gin Leu Ile Arg Asn 725 730 735 Ile Ala Asp Tyr Tyr Arg Arg Asp Asn Ile Leu Glu Gin Lys Gly Ser 740 745 750 Leu Lys Phe Pro Glu Pro Trp Lys Ser Phe Ser Ile Glu Leu Glu Ala 755 760 765 Arg Ile Ser Pro Gin Val Arg Asp Leu Ile Lys Lys Leu Asn Leu Asp 770 775 780 Ser Tyr Leu Asp Val Asp Ile Leu His Ile Lys Pro Val Phe Ile Ser 785 790 795 800 Lys Lys Pro Arg Arg Lys Val Asn Gly Glu Ala His Lys Ser Thr Ile 805 810 815 Arg Ser Leu Ile Gly Ile Asn Glu Ile Gly Lys Thr Val Thr Cys Ile 820 825 830 Lys Thr Arg Leu Glu Asp Ile Pro Phe Asp Glu Asn Gly Asp Phe Pro 835 840 845 Met Tyr Gly Lys Asp Thr Asp Lys Tyr Thr Tyr Thr Ala Ile Lys Glu 850 855 860 Arg Tyr Leu Glu Phe Asn Lys Asp Lys Glu Lys Ala Phe Ser Thr Pro 865 870 875 880 Leu Tyr Lys Leu Lys Arg Asn Gly Glu Pro Gly Asn Gin Ile Lys Ser 885 890 895 Val Lys Ile Ile Asp Thr Arg Asn Ile Val Asn Lys Val Asn Gin Gly 900 905 910 Lys Gly Ile Ala Tyr Asn Ser Asn Ile Ile Arg Val Asp Val Phe Ser 915 920 925 Arg Asp Gin Lys Tyr Tyr Val Val Pro Ile Tyr Leu Arg Asp Phe Ile 930 935 940 Lys Gly Ser Leu Pro Asn Lys Ile Ile Thr Ala Ala Lys Gly Phe Met 945 950 955 960 Gin Trp Pro Glu Thr Asp Asn Ser Tyr Thr Phe Leu Phe Ser Ile Phe 965 970 975 Page 1484 of 3790 Pro Asn Asp Leu Ile Lys Val Val Pro Lys Glu Gly Lys Phe Ile Lys 980 985 990 Ala Lys Asn Glu Asn Lys Glu Asn Ile Asn Leu Thr Glu Ile Leu Gly 995 1000 1005 Asn 818 206 PRT Bacteroides cellulosilyticus 818 Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Cys Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Asn Glu Ala Glu Asn Thr Glu Glu Ile Ser Ser Ile Ile 20 25 30 Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Met Gin Asn 35 40 45 Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 50 55 60 Arg Ser Met Arg Arg Asn Leu Gin Arg Tyr Lys Leu Arg Arg Asp Thr 65 70 75 80 Leu Ile Glu Val Leu Lys Glu His Gly Phe Ile Thr Asp Ser Thr Leu 85 90 95 Leu Ser Glu His Gly Asn Lys Thr Thr Phe Glu Thr Tyr Arg Leu Arg 100 105 110 Page 1485 of 3790 Page 1486 of 3790 Gin Phe Leu Phe Tyr Ser Thr Tyr Leu Glu Met Leu Glu Asp Leu Lys 130 135 140 Gin Thr Gin Ala Gin Leu Phe Glu Thr Ser Gin Thr Pro Val Pro Leu 145 150 155 160 Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gin Pro Ile 165 170 175 Thr Lys His Glu Leu Ala Trp Leu Leu Leu His Phe Asn Thr Lys Arg 180 185 190 Gly Tyr Tyr Gin Arg Arg Gly Glu Leu Glu Asp Thr Pro Thr Asp Lys 195 200 205 Leu Val Glu Tyr His Ala Leu Lys Val Val Asp Val Glu Val Asp Pro 210 215 220 Glu Asp Gin Ser Lys Lys Pro Trp Tyr Phe Val His Leu Glu Asn Gly 225 230 235 240 Trp Ile Tyr Lys Arg Gin Ser Ser Glu Pro Leu Asp Asn Trp Lys Gly 245 250 255 Leu Val Lys Glu Phe Ile Val Thr Thr His Leu Asp Lys Glu Gly Lys 260 265 270 Pro Lys Leu Asp Lys Glu Gly Glu Val Arg Arg Ser Phe Ser Ser Pro 275 280 285 Lys Glu Asp Asp Trp Thr Leu Val Lys Lys Lys Thr Glu Asn Asp Leu 290 295 300 Glu Lys Ser Gly Leu Thr Val Gly Ala Tyr Ile Tyr Gin Thr Leu Leu 305 310 315 320 Asn Lys Pro Asn Gin Lys Ile Arg Gly Gly Leu Ile Lys His Ile Glu 325 330 335 Arg Asn Tyr Tyr Val Glu Glu Leu Glu Gin Ile Leu Arg Page 1487 of 3790 Met Lys Lys Val Leu Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp 15 10 15 Ala Val Val Asn Gin Asn Asp Lys Gly Glu Phe Leu Ser Ile Glu Lys 20 25 30 Ile Gly Ser Arg Ile Ile Pro Met Ser Gin Asp Val Met Asp Lys Phe 35 40 45 Gly Ala Gly Gin Thr Glu Ser Ser Thr Ala Gin Arg Thr Gin Tyr Arg 50 55 60 Gly Val Arg Arg Leu Arg Glu Arg Ser Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 His Arg Val Leu His Ile Leu His Phe Leu Pro Gin His Tyr Asp Ala 85 90 95 Ala Ile Gly Trp Asn Lys Lys Glu Asn Lys Thr Tyr Gly Lys Phe Leu 100 105 110 Pro Gly Val Glu Val Asn Ile Pro Trp Val Ala Thr Asp Gin Gly His 115 120 125 Gin Phe Ile Phe Met Asp Ser Tyr Ala Glu Met Leu Lys Asp Leu Lys 130 135 140 Gin His Gin Pro His Leu Phe Glu Lys Ser Ser Thr Pro Val Pro Leu 145 150 155 160 Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Gin Ala Ile 165 170 175 Ser Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg 180 185 190 Gly Tyr Tyr Gin Leu Arg Gly Glu Glu Val Glu Asp Asn Thr Lys Arg 195 200 205 Glu Glu Phe Tyr Ala Leu Lys Val Val Lys Val Glu Leu Asp Lys Asp 210 215 220 Asn Thr Ser Ala Lys Thr Trp Tyr Lys Val His Leu Glu Asn Gly Phe 225 230 235 240 Ile Tyr Pro Cys Pro Ser Asp Thr Pro Ile Asp Ser Trp Val Gly Met 245 250 255 Page 1488 of 3790 Val Lys Asp Phe Ile Val Thr Thr Thr Leu Glu Lys Asp Gly Ser Glu 260 265 270 Lys Arg Thr Ala Asp Gly Glu Ile Lys Arg Ser Phe Arg Ala Pro Lys 275 280 285 Glu Asp Asp Trp Thr Leu Leu Lys Lys Lys Thr Glu Ser Glu Leu Glu 290 295 300 Lys Ser Gly Lys Gin Val Gly Ala Phe Ile Tyr Asp Thr Leu Leu Ser 305 310 315 320 Asn Pro Asp Gin Lys Ile Ile Gly Gly Leu Ile Lys Thr Ile Glu Arg 325 330 335 Lys Tyr Tyr Lys Lys Glu Leu Glu Gin Ile Leu Glu Thr Gin Gin Lys 340 345 350 Phe Ile Ala Glu Leu Ser Asp Lys Lys Leu Phe Gin Ala Cys Ala Glu 355 360 365 Glu Leu Tyr Pro Leu Asn Asp Ser His Arg Glu Asn Leu Leu Glu Arg 370 375 380 Asp Phe Lys His Leu Phe Val Gin Asp Ile Ile Phe Tyr His Arg Pro 385 390 395 400 Leu Lys Thr Lys Lys Ser Leu Ile Ser Asn Cys Thr Tyr Glu Tyr Arg 405 410 415 Thr Phe Tyr Lys Asn Gly Glu Lys Gin Ile Ser Pro Ile Lys Cys Ile 420 425 430 Ala Lys Ser Asn Pro Leu Phe Gin Glu Phe Arg Val Trp Gin Phe Val 435 440 445 Gin Asn Leu Arg Ile Leu Gin Arg Gin Arg Ser Glu Gly Asp Ser Ile 450 455 460 Lys Tyr Asn Val Asp Val Thr Ala Glu Phe Leu Lys Asp Glu Asn Asp 465 470 475 480 Ile Ala Asn Leu Phe Thr Trp Leu Asn Glu Arg Lys Val Ile Lys Gin 485 490 495 Asp Gin Leu Leu Lys Ser Tyr Phe Lys Leu Lys Val Asn Lys Glu Thr Page 1490 of 3790 Page 1491 of 3790 Page 1492 of 3790 Lys Ile Glu Asn Asp Asp Asp Lys Arg Ser Leu Lys His Ile Cys Page 1493 of 3790 1485 1475 1480 Trp Lys Leu Lys Val Asn Arg Leu Gly Glu Ile Thr Asp Val Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr Page 1495 of 3790 Ala Lys Ser His Pro Leu Phe Gin Glu Phe Arg Leu Trp Asn Phe Leu 435 440 445 Ser Asn Ile Arg Ile Tyr Gin Lys Glu Lys Glu Ile Asn Gly Thr Leu 450 455 460 His Leu Asp Val Asp Val Thr Ala Glu Phe Leu Lys Thr Glu Asp Asp 465 470 475 480 Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Glu Gin 485 490 495 Lys Thr Phe Leu Lys Tyr Pro Lys Phe Gly Leu Lys Lys Glu Ile Ser 500 505 510 Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Gin Tyr Pro Cys Asn Glu 515 520 525 Thr Arg His Ala Ile Leu Ser Ser Leu Glu Lys Ala Asn Val Cys Ile 530 535 540 Asp Phe Leu Ser Asn Glu Lys Glu Val Ala Leu Trp His Ile Leu Tyr 545 550 555 560 Ser Val Ser Asp Lys Gin Glu Ile Glu Lys Ala Leu Arg Thr Phe Ala 565 570 575 Ala Lys Asn Gly Leu Asp Glu Ser Phe Val Glu Ala Phe Lys Lys Phe 580 585 590 Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys 595 600 605 Lys Met Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Val Ser Ser 610 615 620 Ile Asp Asp Thr Thr Lys Glu Arg Ile Lys Lys Ile Val Thr Gly Glu 625 630 635 640 Tyr Asp Glu Arg Ile Ser Val Lys Val Arg Asp Lys Val Met Asn Leu 645 650 655 Ser Asp Ile Ser Cys Phe Arg Arg Leu Pro Leu Trp Leu Ala Cys Tyr 660 665 670 Ile Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ala Val Lys Trp Glu 675 680 685 Page 1496 of 3790 Ser Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ser Phe Lys Gin His Ser 690 695 700 Leu Arg Asn Pro Ile Val Glu Gin Val Ile Thr Glu Thr Leu Arg Val 705 710 715 720 Val Arg Asp Ile Trp Lys Gin Val Gly Arg Ile Asp Glu Ile His Ile 725 730 735 Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 740 745 750 Thr Ala Gin Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 755 760 765 Leu Leu Ala Glu Phe Met Asn Pro Glu Tyr Glu Ile Glu Asn Val Arg 770 775 780 Pro Tyr Ser Pro Ser Gin Gin Glu Ile Leu Arg Ile Tyr Glu Asp Thr 785 790 795 800 Val Leu His Ala Glu Asp Gin Leu Pro Glu Glu Ile Asp Ala Ile Leu 805 810 815 Lys Lys Phe Asn Ser Ser Lys Val Pro Thr Lys Ser Glu Phe Leu Arg 820 825 830 Tyr Lys Leu Trp Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 835 840 845 Leu Ile Pro Leu Gly Lys Leu Phe Thr Ala Ala Tyr Glu Ile Glu His 850 855 860 Val Ile Pro Gin Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val 865 870 875 880 Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Gin Leu Gly Tyr 885 890 895 Glu Phe Ile Lys Asn His His Gly Gin Lys Val Glu Val Gly Phe Gly 900 905 910 Lys Ser Val Glu Ile Phe Ser Val Asp Ser Tyr Glu Arg Phe Val Lys 915 920 925 Glu Gin Tyr Ala Lys Ser Ala Val Lys Met Lys Lys Leu Leu Met Asp 930 935 940 Page 1497 of 3790 Asp Ser Trp Ala Ile Arg Lys Pro Met His Lys Asp Thr Val Phe Page 1499 of 3790 1505 822 1526 PRT Bacteroides faecis 822 Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Val Leu Asn Ala 20 Ala Asp Asp Asn 25 Ser Leu Lys Tyr Ile Glu Ala 30 Ala Gly Ser Arg 35 Ile Ile Pro Met 40 Asp Ala Ala Ile Leu Gly Asp Phe 45 Asp Arg 50 Gly Asn Ser Ile Ser Gin 55 Thr Ala Glu Arg 60 Thr Arg Ile Arg Gly Met Arg His 65 Leu Arg 70 Glu Arg Tyr Leu Leu Arg Arg Ala Arg Leu 75 80 His Arg Ile Leu Asn Leu Leu Gly Phe 85 Leu Pro 90 Phe His Tyr Ala Gin 95 Asp Ile Asp Arg Tyr Gly Asn Phe Ser Ala Asp Met Glu Pro Lys Ile 100 105 110 Page 1500 of 3790 Ala Trp Cys Lys Asn Leu Glu Gly Glu Leu Glu Phe Ile Phe Ile Glu 115 120 125 Ser Phe Asn Glu Met Leu Glu Asp Phe Arg Lys Asn Gin Pro Glu Leu 130 135 140 Val Ala Asp Asn Lys Lys Val Pro Tyr Asp Trp Val Ile Tyr Tyr Leu 145 150 155 160 Arg Lys Lys Ala Leu Glu Lys Lys Ile Ser Lys Glu Glu Leu Ala Trp 165 170 175 Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr Gin Leu Arg Gly 180 185 190 Glu Asp Asp Asp Glu Ser Met Lys Thr Ala Lys Thr Arg Gin Tyr Phe 195 200 205 Asp Lys Gin Ile Ile Lys Asn Ile Ile Asp Thr Asn Gin Thr Tyr Lys 210 215 220 Gly Gin Arg Ile Leu Ile Val Glu Leu Gin Asn Gly Asp Lys Gly Lys 225 230 235 240 Ile Phe Lys Lys Glu Ile Pro Asp Trp Ile Gly Gin Glu Lys Asn Ile 245 250 255 Ile Val Thr Val Asp Ile Asp Lys Asp Gly Asn Asp Lys Tyr Glu Glu 260 265 270 Ser Gly Ser Leu Ser Cys Arg Phe Lys Ile Pro Thr Asp Ala Glu Trp 275 280 285 Glu Ser Glu Trp Lys Leu Ile Lys Met Lys Thr Gin Lys Asp Leu Asp 290 295 300 Glu Ser Asn Lys Thr Val Gly Thr Tyr Ile Tyr Asp Ser Ile Leu Gin 305 310 315 320 Asn Pro Thr Gin Lys Val Arg Gly Lys Leu Val Arg Thr Ile Glu Arg 325 330 335 Lys Tyr Tyr Lys Ala Glu Leu Lys Gin Ile Leu Glu Lys Gin Thr Glu 340 345 350 Phe His Ser Glu Leu Gin Asp Lys Asp Leu Tyr Ile Glu Cys Leu Asn 355 360 365 Page 1501 of 3790 Glu Leu Tyr Ser Asn Asn Asp Thr His Arg Asn Ala Ile Thr Asp Arg 370 375 380 Asp Phe Val Tyr Leu Phe Met Asn Asp Ile Leu Phe Tyr Gin Arg Pro 385 390 395 400 Leu Lys Ser Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Arg Asn 405 410 415 Ile Tyr Ile Asp Lys Glu Thr Gly Glu Ile Lys Tyr Ser Pro Ile Lys 420 425 430 Cys Ile Ala Lys Ser His Pro Leu Phe Gin Glu Phe Arg Leu Trp Lys 435 440 445 Phe Ile Ser Ser Ile Arg Ile Tyr Gin Arg Glu Ser Val Val Glu Val 450 455 460 Val Asp Lys Gin Leu Asp Leu Phe Ser Ser Gin Ser Thr Ser Val Gin 465 470 475 480 Lys Leu Val Thr Asp Val Asp Val Thr Asp Lys Phe Leu Thr Cys Glu 485 490 495 Asn Asp Tyr Val Ala Leu Phe Glu Trp Leu Asn Lys Lys Lys Ile Ile 500 505 510 Asp Gin Lys Glu Phe Leu Lys Tyr Arg Pro Phe Gly Leu Lys Gly Asp 515 520 525 Ile Asp Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys 530 535 540 Asn Glu Thr His Ala Met Ile Leu Thr Tyr Phe Ala Lys Ala Gly Ile 545 550 555 560 Ser Glu Asp Ile Leu Thr Lys Glu Met Glu Glu Ala Leu Trp His Ile 565 570 575 Leu Tyr Ser Val Glu Asp Arg Gin Glu Ile Thr Lys Ala Leu Arg Thr 580 585 590 Phe Ala Ser Lys Tyr His Leu Ser Asp Ser Phe Val Lys Val Phe Ser 595 600 605 Asn Ile Pro Pro Phe Lys Lys Glu Tyr Gly Ser Tyr Ser Ala Lys Ala 610 615 620 Page 1502 of 3790 Ile Lys Lys Leu Leu Ser Leu Met Arg Met Gly Lys Tyr Trp Ser Glu 625 630 635 640 Asp Ala Ile Asp Val Asn Thr Arg Glu Arg Ile Asp Lys Ile Val Thr 645 650 655 Gly Glu Tyr Asp Glu Lys Ile Arg Asp Arg Val Arg Glu Lys Thr Ile 660 665 670 Arg Leu Asn Asp Ile Arg His Phe Arg Ala Leu Pro Asp Trp Leu Ala 675 680 685 Cys Tyr Val Val Tyr Asp Arg His Ser Glu Thr Arg Glu Ile Thr Glu 690 695 700 Trp Lys Ser Pro Glu Glu Ile Asp Glu Tyr Ile Arg Asn Phe Lys Gin 705 710 715 720 His Ser Leu Arg Asn Pro Ile Val Glu Gin Val Ile Thr Glu Thr Leu 725 730 735 Arg Thr Val Arg Asp Ile Trp Lys Gin Val Gly Cys Ile Asp Glu Ile 740 745 750 His Val Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys 755 760 765 Arg Ile Thr Ser Gin Ile Ile Glu Asn Glu Asn Ala Asn Leu Arg Val 770 775 780 Lys Ala Leu Leu Thr Glu Phe Val Asn Ser Glu Phe Glu Ile Glu Asn 785 790 795 800 Val Arg Pro Tyr Ser Leu Ser Gin Gin Asp Ile Leu Arg Ile Tyr Glu 805 810 815 Asp Gly Val Leu Asn Ser Val Ala Glu Val Pro Gly Asp Ile Ala Gly 820 825 830 Ile Leu Lys Lys Phe Asn Glu Asn Asp Ala Lys Lys Arg Pro Thr Thr 835 840 845 Ser Glu Ile Leu Arg Tyr Lys Leu Trp Leu Glu Gin Lys Tyr Arg Ser 850 855 860 Pro Tyr Thr Gly Glu Met Ile Pro Leu Ser Lys Leu Phe Thr Ser Ala 880 865 870 Page 1503 of 3790 875 Asn Glu Ser Ala Ser Arg Lys Ala Lys Ile Ser Arg His Asp Leu 1100 1105 1110 Page 1505 of 3790 823 1509 PRT Bacteroides fluxus 823 Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Val Gly Trp 15 10 15 Ala Val Ile Asn Ser Val Ile Lys Glu Gin Ala Glu Arg Ile Trp Ile 20 25 30 Page 1506 of 3790 Glu Met Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Val Leu Gly 35 40 45 Asp Phe Asp Lys Gly Asn Ser Ile Ser Gin Thr Ser Glu Arg Thr Arg 50 55 60 Leu Arg Gly Val Arg Arg Leu Arg Glu Arg Gin Leu Leu Arg Arg Glu 65 70 75 80 Arg Leu His Lys Val Leu Asn Ile Leu Gly Phe Leu Pro Asn His Tyr 85 90 95 Leu Glu Tyr Ile Asp Phe Glu Lys His Pro Gly Lys Phe Leu Ser Asp 100 105 110 Ala Glu Pro Lys Leu Pro Trp Val Lys Asp Glu Gin Gly Lys Tyr Thr 115 120 125 Phe Leu Phe Gin Ala Ala Phe Asp Glu Met Leu Ala Asp Phe Ala Ile 130 135 140 His Gin Pro Ser Leu Val Ser Gly Asp Lys Lys Ile Pro Tyr Asp Trp 145 150 155 160 Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 165 170 175 Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr 180 185 190 Tyr Gin Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 195 200 205 Glu Phe Tyr Ala Leu Lys Val Leu Thr Val Glu Ala Thr Asp Glu Lys 210 215 220 Lys Gly Arg Asp Val Trp Tyr Asn Val His Leu Glu Asn Gly Trp Ile 225 230 235 240 Tyr Arg Arg Ser Ser Ser Val Pro Leu Asp Trp Glu Gly Gin Ile Lys 245 250 255 Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Ser Thr Pro Lys Leu 260 265 270 Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 275 280 285 Page 1507 of 3790 Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Ala Asn Thr 290 295 300 His Lys Thr Val Gly Ala Tyr Ile Tyr Asp Thr Leu Leu Gin Lys Pro 305 310 315 320 Gin Gin Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Leu 325 330 335 Tyr Arg Asp Glu Leu Ser Leu Ile Leu Gin Lys Gin Cys Ala Phe His 340 345 350 Ala Glu Leu Gin Asp Arg Thr Leu Tyr Ala Arg Cys Val Glu Ala Leu 355 360 365 Tyr Pro Asn Asn Glu Val Gin Arg Arg Asn Ile Ala Asn Arg Asp Phe 370 375 380 Val Tyr Leu Leu Met Asp Asp Val Leu Phe Tyr Gin Arg Pro Leu Lys 385 390 395 400 Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 405 410 415 Val Asp Arg Glu Thr Gly Glu Ile Lys Lys Ala Pro Leu Lys Cys Ile 420 425 430 Ala Lys Ser His Pro Leu Phe Gin Glu Phe Arg Leu Trp Asn Phe Leu 435 440 445 Ser Asn Ile Arg Ile Tyr Gin Lys Glu Lys Glu Ile Asn Gly Thr Leu 450 455 460 His Leu Asp Val Asp Val Thr Ala Glu Phe Leu Lys Thr Glu Asp Asp 465 470 475 480 Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Glu Gin 485 490 495 Lys Thr Phe Leu Lys Tyr Pro Lys Phe Gly Leu Lys Lys Glu Ile Ser 500 505 510 Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Gin Tyr Pro Cys Asn Glu 515 520 525 Thr Arg His Ala Ile Leu Ser Arg Leu Glu Lys Ala Asn Val Cys Ile Page 1509 of 3790 Asn Asp Val Trp Asn Ser Ile Val Tyr Pro Arg Phe Glu Arg Leu 1010 1015 1020 Asn Ser Leu Thr Asp Thr Gin Ser Phe Gly His Trp Glu Asn Lys 1025 1030 1035 Page 1510 of 3790 Page 1511 of 3790 Lys Tyr Arg Ile Asn Glu Page 1512 of 3790 195 200 205 Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg Page 1514 of 3790 Ala Leu Phe Glu Glu Leu Asn Asp Ala Glu Gin Leu Glu Leu Asn Gly 465 470 475 480 Ser Arg Arg Leu Cys Gin Glu Glu Lys Glu Leu Leu Ala Gin Glu Leu 485 490 495 Phe Ile Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 500 505 510 Asp Asn Pro Gin Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 515 520 525 Lys Thr Gly Tyr Ala Leu Phe Gin Ala Tyr Ser Lys Met Ile Glu Met 530 535 540 Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 545 550 555 560 Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 565 570 575 Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gin Ser Tyr Tyr Lys 580 585 590 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 595 600 605 Asn Gly Arg Leu Ile Gin Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 610 615 620 Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gin Asp Asp Tyr Gly 625 630 635 640 Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 645 650 655 Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 660 665 670 Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 675 680 685 Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 690 695 700 Lys Ile Leu Asn Gin Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 705 710 715 720 Page 1515 of 3790 Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 725 730 735 Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gin Thr 740 745 750 Thr Lys Ala His Glu Glu Tyr Lys Thr Leu Leu Gin Thr Glu Phe Gly 755 760 765 Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 770 775 780 Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 785 790 795 800 Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 805 810 815 Pro Gin Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 820 825 830 Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 835 840 845 Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 850 855 860 Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 865 870 875 880 Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gin Asp Ile Pro Asp Gly 885 890 895 Phe Ile Glu Arg Asp Leu Arg Asn Thr Gin Tyr Ile Ala Lys Lys Ala 900 905 910 Leu Ser Met Leu Asn Glu Ile Ser His Arg Val Val Ala Thr Ser Gly 915 920 925 Ser Val Thr Asp Lys Leu Arg Glu Asp Trp Gin Leu Ile Asp Val Met 930 935 940 Lys Glu Leu Asn Trp Glu Lys Tyr Lys Ala Leu Gly Leu Val Glu Tyr 945 950 955 960 Phe Glu Asp Arg Asp Gly Arg Gin Ile Gly Arg Ile Lys Asp Trp Thr 965 970 975 Page 1516 of 3790 Lys Arg Asn Asp His Arg His His Ala Met Asp Ala Leu Thr Val Ala 980 985 990 Phe Thr Lys Asp Val Phe Ile Gin Tyr Phe Asn Asn Lys Asn Ala Ser 995 1000 1005 Tyr Gly Asn Asp Ala Lys Lys Ala Phe Ser Asn Leu Asp Glu Asn Page 1517 of 3790 Page 1518 of 3790 Leu Gly Thr Asn Ser Ile Gly Trp 10 15 Gly Pro Ile Val Lys Lys Arg Ile 25 30 Pro Met Asp Ala Ala Val Leu Gly 45 Ser Gin Thr Ala Glu Arg Thr Ser 60 Glu Arg Gin Leu Leu Arg Arg Glu 75 80 Leu Gly Phe Leu Pro Glu His Tyr 90 95 His Pro Gly Lys Ile Lys Arg Asn 105 110 Lys Asn Ser Met Gly Gin Phe Glu 125 Ala Met Leu Thr Asp Phe Ala Thr 140 Gly Lys Lys Val Pro Tyr Asp Trp 155 160 Ala Leu Thr Glu Gly Ile Ser Lys 170 175 Asn Phe Asn Gin Lys Arg Gly Tyr 185 190 Glu Glu Gin Ser Asn Lys Leu Val 205 Lys Val Glu Ala Thr Asp Asp Lys 220 Page 1519 of 3790 Lys Gly Lys Asp Thr Trp Tyr Asn Val His Leu Glu Asn Gly Trp Ile 225 230 235 240 Tyr Arg Arg Thr Ser Asn Ile Pro Leu Asp Trp Glu Gly Lys Val Lys 245 250 255 Glu Phe Ile Val Thr Thr Asp Leu Asn Glu Asp Gly Thr Pro Lys Leu 260 265 270 Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 275 280 285 Asp Trp Thr Leu Ile Lys Lys Lys Thr Glu Ser Asp Ile Ala Asn Ser 290 295 300 His Lys Thr Val Gly Cys Tyr Ile Tyr Asp Ala Leu Leu Gin Asn Pro 305 310 315 320 His Gin Lys Ile Lys Gly Arg Leu Val Arg Thr Val Glu Arg Lys Phe 325 330 335 Tyr Lys Glu Glu Leu Arg Leu Ile Leu Glu Lys Gin Leu Ser Phe His 340 345 350 Pro Glu Leu Gin Asp Arg Asp Leu Tyr Arg Ala Cys Ile Asp Ala Leu 355 360 365 Tyr Val Ser Asn Glu Ala His Lys Asn Asn Ile Ser Gly Arg Asp Phe 370 375 380 Val Tyr Leu Phe Ile Asp Asp Ile Ile Phe Tyr Gin Arg Pro Leu Lys 385 390 395 400 Thr Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Glu Asn Gin Tyr 405 410 415 Met Asp Arg Glu Thr Gly Glu Val Lys Gin Ala Pro Ile Lys Cys Ile 420 425 430 Ala Lys Ser His Pro Leu Phe Gin Glu Phe Arg Leu Trp Gin Phe Ile 435 440 445 Ser Asn Ile Arg Ile Tyr Gin Arg Glu Arg Val Leu Asp Asp Gly Lys 450 455 460 Leu Glu Thr Asp Val Asp Val Thr Pro Asp Phe Leu Lys Thr Glu Asp 465 470 475 480 Page 1520 of 3790 Asp Tyr Thr Thr Leu Phe Glu Trp Phe Asn Asp Arg Lys Glu Val Asp 485 490 495 Gin Lys Ala Phe Leu Lys Asn Pro Gin Phe Gly Leu Lys Lys Thr Phe 500 505 510 Thr Glu Tyr Arg Trp Asn Tyr Val Glu Asp Lys Ser Tyr Pro Cys Asn 515 520 525 Glu Thr Arg Asn Ala Ile Leu Asn Gly Leu Gin Lys Ala Gly Val Ser 530 535 540 Ala Asp Phe Leu Ser Arg Glu Val Glu Glu Ala Leu Trp His Ile Leu 545 550 555 560 Tyr Ser Val Glu Asp Lys Ile Glu Ile Glu Ser Ala Leu Arg Lys Phe 565 570 575 Ala Ser Lys His Asp Leu Asp Asp Arg Phe Ala Asp Val Phe Lys Lys 580 585 590 Leu Pro Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile 595 600 605 Lys Lys Leu Leu Pro Leu Met Arg Ile Gly Lys Tyr Trp Glu Leu Ser 610 615 620 Asn Ile Asp Asp Lys Thr Lys Glu Arg Ile Asp Lys Ile Ile Thr Gly 625 630 635 640 Glu Trp Asp Glu Asn Ile His Asp Arg Val Arg Glu Lys Ala Ile Lys 645 650 655 Leu Ser Asp Ile Thr Asp Phe Lys Gly Leu Pro Leu Trp Leu Ser Cys 660 665 670 Tyr Val Val Tyr Asn Arg His Ser Glu Ala Arg Ala Ile Ala Lys Trp 675 680 685 Glu Ser Pro Glu Asp Ile Asp Ser Tyr Leu Arg Leu Phe Arg Gin His 690 695 700 Ser Leu Arg Asn Pro Ile Val Glu Gin Val Ile Thr Glu Thr Leu Arg 705 710 715 720 Thr Val Arg Asp Ile Trp Lys Arg Val Gly Gin Ile Asp Glu Ile His 725 730 735 Page 1521 of 3790 Val Glu Leu Gly Arg Glu Ile Lys Asn Pro Ala Asp Lys Arg Ala Lys 740 745 750 Met Thr Ala Gin Ile Val Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys 755 760 765 Ala Leu Leu Ala Glu Phe Ile Asn Ser Glu Tyr Glu Ile Glu Asn Val 770 775 780 Arg Pro Tyr Ser Ser Asn Gin Gin Glu Lys Leu Lys Ile Tyr Glu Asp 785 790 795 800 Thr Val Leu Asn Gly Val Lys Glu Ile Pro Glu Asp Ile Asn Thr Ile 805 810 815 Leu Lys Lys Phe Arg Glu Ser Asp Leu Lys Lys Arg Pro Thr Lys Ser 820 825 830 Asp Phe Leu His Tyr Lys Leu Trp Leu Glu Gin Lys Tyr Cys Ser Pro 835 840 845 Tyr Thr Gly Arg Ile Ile Pro Leu Gly Lys Leu Phe Thr Ser Ala Tyr 850 855 860 Glu Ile Glu His Ile Ile Pro Gin Ala His Tyr Phe Asp Asp Ser Phe 865 870 875 880 Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn Gly Leu Lys Asp Lys 885 890 895 Lys Leu Gly Tyr Glu Phe Ile Lys His Asn Pro Gly Lys Met Val Glu 900 905 910 Ile Gly Phe Gly Lys Pro Pro Val Arg Ile Phe Ser Val Glu Glu Tyr 915 920 925 Glu Arg Phe Val Lys Glu Asn Tyr Ser Gly Ile Lys Asn Lys Met Asn 930 935 940 Lys Leu Leu Met Asp Asp Ile Pro Glu Thr Phe Ile Glu Arg Gin Leu 945 950 955 960 Asn Asp Ser Arg Tyr Ile Ser Lys Val Val Lys Ser Leu Leu Ser Asn 965 970 975 Ile Val Arg Glu Lys Asp Ser Asn Gly Glu Tyr Glu Pro Glu Ala Ile 980 990 Page 1522 of 3790 985 Ser Lys Asn Val Ile Val Cys Thr Gly Ser Val Thr Asp Arg Leu Lys 995 1000 1005 Page 1523 of 3790 Page 1524 of 3790 Lys Asn Ala Ile Ile Pro Val Ile 1470 Glu Lys Ser Trp Asn Asn Glu 1485 Ile Arg Val Asp Arg Leu Gly 1500 826 779 PRT Bacteroides oleiciplenus 826 Met Lys Glu Gly Asn Gin Tyr Asp 1 5 Val Ala Cys Glu Tyr Ala Gly Tyr 10 15 Arg His Ser Lys Ser Ser Leu Thr 20 Arg Glu Glu Ile Asp Asn Lys Val 25 30 Leu Lys Asn Arg Leu Glu Ile Leu 35 40 Pro Lys Asn Ser Leu Arg Asn Pro 45 Val Val Glu Lys Ile Leu Asn Gin 50 55 Met Val Asn Val Val Asn Ala Val 60 Ile Asp Thr Tyr Gly Lys Pro Asp 65 70 Glu Ile Arg Val Glu Leu Ala Arg 75 80 Glu Leu Lys Lys Gly Ala Lys Glu 85 Arg Glu Glu Leu Ala Lys Ser Ile 90 95 Ala Gin Asn Thr Arg Glu His Glu 100 Ala Ile Arg Gin Leu Leu Gin Thr 105 110 Glu Phe Gly Met Met His Val Thr 115 120 Arg Asn Asp Ile Ile Arg Tyr Lys 125 Leu Tyr Glu Glu Leu Lys Asp Asn 130 135 Gly Tyr Lys Thr Leu Tyr Ser Asp 140 Gin Tyr Ile Pro Arg Glu Lys Val 145 150 Phe Ser Lys Glu Ile Asp Ile Glu 155 160 Page 1525 of 3790 His Ile Ile Pro Gin Ala Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys 165 170 175 Thr Leu Glu Tyr Arg Ala Val Asn Ile Glu Lys Gly Asn Lys Thr Ala 180 185 190 Tyr Asp Phe Val Lys Glu Lys Tyr Gly Asn Asp Gly Leu Arg Arg Tyr 195 200 205 Leu Asn His Cys Glu Ala Leu Phe Lys Asp Lys Lys Thr Lys Leu Lys 210 215 220 Lys Leu Lys Met Glu Asp Gin Asp Ile Pro Asp Gly Phe Ile Asp Arg 225 230 235 240 Asp Leu Arg Asn Thr Gin Tyr Ile Ala Lys Lys Ala Leu Ser Met Leu 245 250 255 Ser Glu Ile Ser Arg Arg Val Val Ala Thr Thr Gly Ser Ile Thr Asp 260 265 270 Glu Leu Arg Lys Asp Trp Gin Leu Val Asp Ile Met Lys Glu Leu Asn 275 280 285 Leu Pro Lys Tyr Glu Ala Leu Gly Phe Val Glu Thr Phe Lys Asp Lys 290 295 300 Asp Gly Arg Ile Ile Lys Lys Ile Lys Asp Trp Ser Lys Arg Asn Asp 305 310 315 320 His Arg His His Ala Met Asp Ala Leu Thr Val Ala Phe Thr Lys Asp 325 330 335 Val Phe Ile Gin Tyr Phe Asn Asn Lys Asn Ala Phe Trp Met Ser Gly 340 345 350 Ser Lys Glu His Ala Asn Ile Thr Ala Ile Lys Asn Lys Tyr Phe Glu 355 360 365 Lys Gly Lys Ala Leu Ala Pro Ile Pro Leu Glu Leu Phe Arg Thr Glu 370 375 380 Ala Lys His His Leu Glu Asn Ile Leu Val Ser Ile Lys Ala Lys Asn 385 390 395 400 Lys Val Val Thr Asn Asn Ile Asn Arg Thr Lys Lys Lys Asn Gly Glu 405 410 415 Page 1526 of 3790 Asn Leu Lys Leu Gin Gin Thr Pro Arg Gly Gin Leu His Leu Glu Ser 420 425 430 Ile Tyr Gly Ser Tyr Arg Gin Cys Ile Ile Arg Asp Glu Lys Val Asn 435 440 445 Ala Ser Phe Asp Ala Ser Lys Ile Ala Asn Val Ser Lys Ser Ala Tyr 450 455 460 Arg Asn Ala Leu Leu Lys Arg Leu Glu Ala Tyr Asp Asn Asp Pro Lys 465 470 475 480 Lys Ala Phe Thr Gly Lys Asn Ser Leu Asp Lys Asn Pro Val Tyr Leu 485 490 495 Asp Glu Asn Lys Met Glu Lys Val Pro Asp Arg Val Lys Ile Val Glu 500 505 510 Phe Glu Thr Val Tyr Thr Ile Arg Lys Pro Ile Asp Pro Lys Leu Ser 515 520 525 Ile Asp Lys Val Val Asp Ala Arg Ile Arg Thr Leu Leu Lys Lys Arg 530 535 540 Leu Glu Glu Tyr Gly Gly Asp Ala Gin Arg Ala Phe Ser Asn Ile Glu 545 550 555 560 Glu Asn Pro Ile Trp Leu Asn Lys Glu Lys Gly Ile Ser Val Lys Arg 565 570 575 Val Ala Ile Arg Gly Ile Ser Asn Ala Gin Ala Leu His Asp Lys Lys 580 585 590 Asp Lys Asp Gly Asn Pro Ile Leu Asp Lys Glu Gly Lys Gly Ile Pro 595 600 605 Thr Asp Phe Val Asn Thr Ser Asn Asn His His Val Ala Ile Tyr Arg 610 615 620 Lys Pro Val Val Asp Lys Met Gly Gin Val Ile Leu Asp Glu Asn Gly 625 630 635 640 Ser Pro Arg Tyr Glu Leu Gly Glu Asp Val Ile Ser Phe Phe Glu Ala 645 650 655 Val Ala Arg Val Asn Leu Arg Gin Pro Val Val Asp Lys Asp Tyr Lys 770 775 827 653 PRT Bacteroides oleiciplenus 827 Met Ser Glu Gin Gly Asn Lys Thr Thr Phe Glu Thr Tyr Arg Leu Arg 325 330 335 Asp Lys Asn Pro Asn Gly Ser Leu Arg Asn Lys Val Phe Tyr Arg Gin 340 345 350 Page 1529 of 3790 Asp Tyr Leu Asp Glu Phe Asn Thr Ile Trp Glu Lys Gin Ser Leu Tyr 355 360 365 His Lys Glu Leu Thr Val Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 370 375 380 Ile Phe Tyr Gin Arg Arg Leu Lys Ser Gin Lys Gly Leu Ile Ser Thr 385 390 395 400 Cys Glu Phe Glu Gin Arg Glu Ile Ile Val Glu Lys Asp Gly Lys Arg 405 410 415 Lys Thr Lys Ile Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu 420 425 430 Phe Gin Glu Phe Lys Ile Trp Gin Thr Leu Asn Asp Val Glu Val Tyr 435 440 445 Val Ala Asp Arg Arg Thr Lys Arg Lys Gin Asp Arg Lys Ser Thr Thr 450 455 460 Leu Phe Ser Asp Thr Glu Asp Ile Leu Leu Val Glu Gly Lys Arg Tyr 465 470 475 480 Leu Tyr Gin Glu Glu Lys Glu Leu Leu Ala Lys Glu Leu Phe Val Arg 485 490 495 Glu Asn Met Lys Lys Ala Glu Val Leu Lys Leu Leu Phe Glu Asp Pro 500 505 510 Lys Glu Leu Asp Leu Asn Phe Lys Gin Ile Asp Gly Asn Arg Thr Gly 515 520 525 Phe Ala Leu Phe Ser Ala Tyr Ser Lys Met Ile Glu Lys Tyr Gly Tyr 530 535 540 Glu Ser Val Asn Phe Lys Asn Ser Ala Asp Glu Ile Ile Glu Lys Leu 545 550 555 560 Gin Ile Ile Phe Ala Asp Leu Gly Trp Asn Thr Glu Leu Phe Ser Ile 565 570 575 Asp Leu Ser Lys Asp Asp Lys Glu Leu Glu Lys Gin Pro Tyr Phe Arg 580 585 590 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 595 600 605 Page 1530 of 3790 Page 1531 of 3790 Leu Asp Ala Gly Lys Lys Tyr Leu Pro Asp Phe Tyr Arg Ser Asp Leu 180 185 190 Gin Asn Glu Leu Asp Arg Ile Trp Glu Lys Gin Lys Glu Tyr Tyr Pro 195 200 205 Glu Ile Leu Thr Glu Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 210 215 220 Asp Ala Val Trp Ala Ile Cys Ala Lys Ser Phe Val Trp Glu Glu Tyr 225 230 235 240 Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gin Gin Glu Arg 245 250 255 Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 260 265 270 Lys Arg Glu Asn Leu Gin Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 275 280 285 Ser Leu Glu Gin Leu Val Ile Val Leu Gin Glu Met Asn Ile Gin Ile 290 295 300 Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 305 310 315 320 Leu Tyr Phe Asn Lys Gin Thr Val Gly Gin Tyr Gin Met Glu Met Leu 325 330 335 Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gin 340 345 350 Asp Tyr Leu Asp Glu Phe Asn Thr Leu Trp Glu Lys Gin Ala Glu Tyr 355 360 365 His Lys Glu Leu Thr Gly Glu Leu Lys Lys Glu Ile Arg Asp Ile Val 370 375 380 Ile Phe Tyr Gin Arg Arg Leu Lys Ser Gin Lys Gly Leu Val Gly Phe 385 390 395 400 Cys Glu Phe Glu Ser Arg Gin Ile Glu Val Glu Ile Asp Gly Lys Lys 405 410 415 Lys Ile Lys Thr Val Gly Asn Arg Val Ile Pro Arg Ser Ser Pro Leu 420 425 430 Page 1532 of 3790 Phe Gin Glu Phe Lys Ile Trp Gin Ile Leu Asn Asn Ile Glu Val Thr 435 440 445 Val Val Gly Lys Lys Gly Lys Arg Arg Lys Gin Lys Asp Asn Ser Pro 450 455 460 Thr Leu Phe Asp Gly Leu Asp Asp Thr Glu Gin Leu Glu Leu Asn Gly 465 470 475 480 Ser Arg Tyr Leu Tyr Gin Glu Glu Lys Glu Leu Leu Ala Gin Glu Leu 485 490 495 Phe Val Arg Asp Lys Met Thr Lys Ser Asp Val Leu Lys Leu Leu Phe 500 505 510 Asp Asn Pro Gin Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 515 520 525 Lys Thr Gly Tyr Thr Leu Phe Gin Ala Tyr Ser Lys Met Ile Glu Met 530 535 540 Ser Gly His Glu Pro Val Asp Phe Lys Lys Thr Val Glu Lys Val Val 545 550 555 560 Glu His Val Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 565 570 575 Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gin Ser Tyr Tyr Lys 580 585 590 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 595 600 605 Asn Ala Arg Leu Val Gin Lys Ile Thr Glu Leu Tyr Gly Phe Glu Lys 610 615 620 Glu Tyr Ala Ile Ile Leu Ala Asn Val Thr Phe Gin Asp Asp Tyr Gly 625 630 635 640 Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 645 650 655 Gly Asn Arg Tyr Asp Val Ala Cys Ala Tyr Ala Gly Tyr Lys His Ser 660 665 670 Glu Ser Ser Leu Thr Lys Glu Glu Ile Ala Asn Lys Ala Leu Lys Asp Page 1533 of 3790 675 680 685 Arg Leu Thr Leu Leu Pro Lys Asn Asn Leu Arg Asn Pro Val Val Glu 690 695 700 Lys Ile Leu Asn Gin Met Val Asn Val Ile Asn Ala Ile Ile Asp Thr 705 710 715 720 Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 725 730 735 Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Phe Ile Ala Glu Thr 740 745 750 Thr Arg Lys His Glu Glu Phe Lys Ile Leu Leu Gin Ser Glu Phe Gly 755 760 765 Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 770 775 780 Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 785 790 795 800 Pro Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 805 810 815 Pro Gin Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 820 825 830 Ala Arg Ser Ile Asn Leu Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 835 840 845 Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Asp His 850 855 860 Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 865 870 875 880 Thr Lys Tyr Asn Lys Leu Lys Met Ala Glu Gin Asp Ile Pro Asp Gly 885 890 895 Phe Ile Asn Arg Asp Leu Arg Asn Thr Gin Tyr Ile Ala Lys Lys Ala 900 905 910 Leu Ser Met Leu Asn Glu Ile Ser Arg Arg Val Val Ala Thr Ser Gly 915 920 925 Page 1534 of 3790 Page 1535 of 3790 Page 1536 of 3790 Lys Gly Leu Asp Ala Ile Val Lys Val Arg Val Asn His Ile Gly 1415 1420 1425 Gin Ile Val Ser Val Gly Glu Tyr 1430 1435 829 1510 PRT Bacteroides sp. 829 165 170 175 Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr Gin Leu Arg Gly Glu Glu 180 185 190 Page 1537 of 3790 Glu Glu Glu Asn Pro Asn Lys Leu Val Glu Tyr Tyr Ser Leu Lys Ile 195 200 205 Val Asp Val Ile Ala Asp Glu Lys Pro Asn Ser Lys Gly Asp Ile Trp 210 215 220 Tyr Ser Leu His Leu Glu Asn Gly Trp Ile Tyr Arg Arg Ser Ser Lys 225 230 235 240 Ile Pro Leu Phe Gly Trp Lys Asp Lys Thr Arg Asp Phe Ile Val Thr 245 250 255 Thr Asp Leu Asn Asp Asp Gly Thr Val Lys Lys Asp Lys Glu Gly Ile 260 265 270 Glu Lys Arg Ser Phe Arg Ala Pro Ser Glu Asn Asp Trp Val Leu Leu 275 280 285 Lys Lys Lys Thr Glu Ser Asp Ile Glu Lys Ser His Lys Thr Val Gly 290 295 300 Ala Tyr Val Tyr Glu Thr Leu Leu Gin Asn Pro Met Gin Lys Val Arg 305 310 315 320 Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys Asp Glu Leu 325 330 335 Lys Gin Ile Leu Glu Lys Gin Arg Glu Phe His Pro Glu Leu Arg Asp 340 345 350 Glu Asp Leu Tyr Asn Asp Cys Val Arg Glu Leu Tyr Arg Ser Asn Glu 355 360 365 Thr Tyr Gin Phe Ile Leu Ser Lys Arg Asp Phe Val His Leu Phe Leu 370 375 380 Asp Asp Ile Leu Phe Tyr Gin Arg Pro Leu Arg Ser Gin Lys Ser Ala 385 390 395 400 Ile Gly Asp Cys Ile Leu Glu Phe Lys Thr Tyr Lys Asp Lys Asp Gly 405 410 415 Asn Asn Ile Lys Glu Tyr Leu Lys Val Ile Ser Lys Ser Asn Pro Leu 420 425 430 Tyr Gin Glu Phe Arg Ile Trp Gin Trp Leu Tyr Asn Leu Lys Ile Tyr Page 1538 of 3790 435 440 445 Arg Lys Glu Asp Asp Glu Asp Val Thr Leu Gin Phe Ile Ala Asn Ile 450 455 460 Glu Asp Lys Glu Gin Leu Phe Asp Phe Leu Ser Asn Arg Lys Ser Ile 465 470 475 480 Glu Gin Lys Pro Leu Leu Glu Tyr Leu Ile Lys Ala Lys Gly Leu Lys 485 490 495 Lys Gin Val Lys Thr Glu Ala Tyr Arg Trp Asn Tyr Val Glu Asp Lys 500 505 510 Ile Tyr Pro Cys Ser Glu Thr Lys Thr Met Ile Ser Thr Arg Leu Ala 515 520 525 Lys Val Glu Asn Ile Pro Asp Asn Phe Phe Thr Lys Glu Ile Glu Gin 530 535 540 Lys Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Asn Glu Phe Glu 545 550 555 560 Lys Ala Leu Arg Thr Phe Ala Lys Lys Tyr Asp Leu Asp Ile Ala Ser 565 570 575 Phe Val Asp Asn Phe Lys Lys Ile Pro Pro Phe Lys Asn Glu Tyr Gly 580 585 590 Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Leu 595 600 605 Gly Lys Tyr Trp Lys Trp Asn Asp Ile Asp Asn Asn Thr Gin Asn Arg 610 615 620 Ile Ser Lys Ile Ile Thr Gly Glu Tyr Asp Glu Glu Ile Lys Asp Ile 625 630 635 640 Val Arg Glu Lys Ser Ile Ala Leu Thr Asn Glu Asn Asp Phe Gin Gly 645 650 655 Leu Gin Leu Trp Leu Ala Gin Tyr Leu Val Tyr Gly Arg His Ser Glu 660 665 670 Ala Asp Ile Ala Gly Lys Trp His Ser Val Ala Asp Leu Glu Lys Tyr 675 680 685 Page 1539 of 3790 Leu Asn Glu Phe Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin 690 695 700 Ile Ile Thr Glu Thr Leu Arg Val Val Arg Asp Ile Trp Arg Lys Tyr 705 710 715 720 Gly Gin Gly Ala Glu Asn Phe Phe Ser Glu Ile His Val Glu Leu Gly 725 730 735 Arg Asp Met Lys Asn Thr Ala Asp Glu Arg Lys Lys Ile Val Asn Val 740 745 750 Val Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Met 755 760 765 Glu Leu Lys Asn Asn Ser Asp Gly Lys Leu Glu Val Glu Asn Val Arg 770 775 780 Pro Tyr Ser Pro Thr Gin Gin Asp Ile Leu Lys Ile Tyr Glu Glu Tyr 785 790 795 800 Ala Ile Ser Thr Gly Leu Asp Asn Glu Lys Asp Glu Lys Val Lys Glu 805 810 815 Asp Ile Lys Lys Ile Ser Arg Val Ala Gin Pro Thr Thr Thr Glu Leu 820 825 830 Gin Arg Tyr Lys Leu Trp Leu Glu Gin Lys Tyr Cys Ser Pro Tyr Thr 835 840 845 Gly Lys Val Ile Pro Leu Gly Lys Leu Phe Thr Glu Glu Tyr Gin Ile 850 855 860 Glu His Ile Ile Pro Lys Ser Arg Tyr Tyr Asp Asp Ser Phe Ser Asn 865 870 875 880 Lys Val Ile Cys Glu Ala Ala Val Asn Lys Leu Lys Asp Lys Cys Leu 885 890 895 Gly Leu Glu Phe Ile Lys Asn Tyr His Gly Gin Ile Val Glu Thr Gly 900 905 910 Phe Gly Gin Lys Val Thr Ile Phe Asp Glu Glu Ala Tyr Gin Asn Phe 915 920 925 Val Lys Gin His Tyr Ala Tyr Asn Arg Ser Lys Arg Thr Lys Leu Leu 930 935 940 Page 1540 of 3790 Page 1541 of 3790 Ser Pro Asn Asp Leu Val Tyr Val Pro Ile Glu Asp Glu Arg Glu 830 1436 PRT Bacteroides sp. 830 Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Asn Glu Ala Glu Asn Lys Asp Glu Arg Ser Ser Ile Val 20 25 30 Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn 35 40 45 Phe Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asp Arg Thr Leu Lys 50 55 60 Arg Gly Met Arg Arg Asn Leu Gin Arg Tyr Lys Leu Arg Arg Glu Thr 65 70 75 80 Leu Thr Glu Val Leu Lys Glu His Lys Leu Ile Thr Glu Asp Thr Ile 85 90 95 Leu Ser Glu Asn Gly Asn Arg Thr Thr Phe Glu Thr Tyr Arg Leu Arg 100 105 110 Ala Lys Ala Val Thr Glu Glu Ile Ser Leu Glu Glu Phe Ala Arg Val Page 1543 of 3790 115 120 125 Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 130 135 140 Lys Gly Val Glu Glu Gly Thr Leu Ile Asp Gly Met Asp Ile Ala Arg 145 150 155 160 Glu Leu Tyr Asn Asn Asn Leu Thr Pro Gly Glu Leu Cys Leu Gin Leu 165 170 175 Leu Asp Ala Gly Lys Lys Phe Leu Pro Asp Phe Tyr Arg Ser Asp Leu 180 185 190 Gin Asn Glu Leu Asp Arg Ile Trp Glu Lys Gin Lys Glu Tyr Tyr Pro 195 200 205 Glu Ile Leu Thr Asp Val Leu Lys Glu Glu Leu Arg Gly Lys Lys Arg 210 215 220 Asp Ala Val Trp Ala Ile Cys Ala Lys Tyr Phe Val Trp Lys Glu Thr 225 230 235 240 Tyr Thr Glu Trp Asn Lys Glu Lys Gly Lys Thr Glu Gin Gin Glu Arg 245 250 255 Glu His Lys Leu Glu Gly Ile Tyr Ser Lys Arg Lys Arg Asp Glu Ala 260 265 270 Lys Arg Glu Asn Leu Gin Trp Arg Val Asn Gly Leu Lys Glu Lys Leu 275 280 285 Ser Leu Glu Gin Leu Val Ile Val Phe Gin Glu Met Asn Thr Gin Ile 290 295 300 Asn Asn Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu 305 310 315 320 Leu Tyr Phe Asn Lys Gin Thr Val Gly Gin Tyr Gin Met Glu Met Leu 325 330 335 Asp Lys Asn Pro Asn Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gin 340 345 350 Asp Tyr Leu Asp Glu Phe Asn Met Leu Trp Glu Lys Gin Ala Val Tyr 355 360 365 Page 1544 of 3790 His Lys Glu Leu Thr Glu Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 370 375 380 Ile Phe Tyr Gin Arg Arg Leu Lys Ser Gin Lys Gly Leu Ile Gly Phe 385 390 395 400 Cys Glu Phe Glu Ser Arg Gin Ile Glu Val Asp Ile Asp Gly Lys Lys 405 410 415 Lys Ile Lys Thr Val Gly Asn Arg Val Ile Ser Arg Ser Ser Pro Leu 420 425 430 Phe Gin Glu Phe Lys Ile Trp Gin Ile Leu Asn Asn Ile Glu Val Thr 435 440 445 Val Val Gly Lys Lys Arg Lys Arg Arg Lys Leu Lys Glu Asn Tyr Ser 450 455 460 Ala Ile Phe Glu Glu Leu Asn Asp Ala Glu Gin Leu Glu Leu Asn Gly 465 470 475 480 Ser Arg Arg Leu Cys Gin Glu Glu Lys Glu Leu Leu Ala Gin Glu Leu 485 490 495 Phe Val Arg Asp Lys Met Thr Lys Ser Glu Val Leu Lys Leu Leu Phe 500 505 510 Asp Asn Pro Gin Glu Leu Asp Leu Asn Phe Lys Thr Ile Asp Gly Asn 515 520 525 Lys Thr Gly Tyr Ala Leu Phe Gin Ala Tyr Ser Lys Met Ile Glu Met 530 535 540 Ser Gly His Glu Pro Val Asp Phe Lys Lys Pro Val Glu Lys Val Val 545 550 555 560 Glu Tyr Ile Lys Ala Val Phe Asp Leu Leu Asn Trp Asn Thr Asp Ile 565 570 575 Leu Gly Phe Asn Ser Asn Glu Glu Leu Asp Asn Gin Ser Tyr Tyr Lys 580 585 590 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 595 600 605 Asn Gly Arg Leu Ile Gin Lys Met Thr Glu Leu Tyr Gly Phe Glu Lys 610 615 620 Page 1545 of 3790 Glu Tyr Ala Thr Ile Leu Ala Asn Val Ser Phe Gin Asp Asp Tyr Gly 625 630 635 640 Ser Leu Ser Ala Lys Ala Ile His Lys Ile Leu Pro His Leu Lys Glu 645 650 655 Gly Asn Arg Tyr Asp Val Ala Cys Val Tyr Ala Gly Tyr Arg His Ser 660 665 670 Glu Ser Ser Leu Thr Arg Glu Glu Ile Ala Asn Lys Val Leu Lys Asp 675 680 685 Arg Leu Met Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 690 695 700 Lys Ile Leu Asn Gin Met Val Asn Val Ile Asn Val Ile Ile Asp Ile 705 710 715 720 Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 725 730 735 Lys Asn Ala Lys Glu Arg Glu Glu Leu Thr Lys Ser Ile Ala Gin Thr 740 745 750 Thr Lys Ala Asn Glu Glu Tyr Lys Thr Leu Leu Gin Thr Glu Phe Gly 755 760 765 Leu Thr Asn Val Ser Arg Thr Asp Ile Leu Arg Tyr Lys Leu Tyr Lys 770 775 780 Glu Leu Glu Ser Cys Gly Tyr Lys Thr Leu Tyr Ser Asn Thr Tyr Ile 785 790 795 800 Ser Arg Glu Lys Leu Phe Ser Lys Glu Phe Asp Ile Glu His Ile Ile 805 810 815 Pro Gin Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 820 825 830 Ala Arg Ser Val Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 835 840 845 Val Lys Glu Lys Phe Gly Glu Ser Gly Ala Asp Asn Ser Leu Glu His 850 855 860 Tyr Leu Asn Asn Ile Glu Asp Leu Phe Lys Ser Gly Lys Ile Ser Lys 865 870 875 880 Page 1546 of 3790 Thr Val Ser Lys Ser Ala Tyr Arg Asp Ala Leu Leu Lys Arg Leu 831 1424 PRT Bacteroides sp. 831 Page 1549 of 3790 Leu Leu Met Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 130 135 140 Lys Lys Glu Glu Asp Gly Val Leu Ile Asp Gly Met Glu Ile Ala Lys 145 150 155 160 Lys Leu Tyr Glu Glu Asp Leu Thr Pro Gly Gin Leu Cys Ser Gin Leu 165 170 175 Leu Glu Ser Gly Lys Lys Val Leu Pro Asp Phe Tyr His Ser Asp Leu 180 185 190 Gin Glu Glu Leu Asp Arg Ile Trp Ser Val Gin Lys Gin Phe His Pro 195 200 205 Asp Val Phe Cys Asp Ala Ala Lys Glu Glu Ile Lys Gly Lys Asn Arg 210 215 220 Ser Gin Thr Trp Ala Ile Leu Ala Asn Tyr Phe Val Trp Lys Glu Glu 225 230 235 240 Val Val Gly Trp Asn Asp Arg Glu Ala Lys Asn Glu Thr Ile Glu Lys 245 250 255 Glu Cys Lys Leu Val Gly Leu Lys Arg Thr Thr Lys Gly Tyr Glu Leu 260 265 270 Lys Lys Glu Asn Tyr Arg Trp Arg Ala Gin Ala Leu Thr Glu Gin Leu 275 280 285 Gly Leu Glu Glu Ile Ala Val Val Leu Gin Glu Ile Asn Gly Gin Ile 290 295 300 Asn Ala Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val 305 310 315 320 Leu Tyr Phe Asn His Gin Thr Val Gly Gin Tyr Gin Met Ala Glu Leu 325 330 335 Asp Lys Asn Pro His Ala Ser Leu Arg Asn Met Val Phe Tyr Arg Gin 340 345 350 Asp Tyr Leu Asp Glu 355 Phe Asp Arg 360 Ile Trp Glu Lys Gin Ala Glu Phe 365 His Lys Glu Leu Thr Ala Glu Leu Lys Lys Glu Ile Arg Asp Met Ile 370 375 380 Page 1550 of 3790 Ile Phe Tyr Gin Arg Arg Leu Lys Ser Gin Lys Gly Leu Ile Ser Phe 385 390 395 400 Cys Glu Phe Glu Arg Leu Glu Ile Val Val Glu Lys Asp Gly Lys Lys 405 410 415 Gin Thr Lys Val Ile Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu 420 425 430 Phe Gin Glu Phe Lys Val Trp Gin Thr Leu Asn Asp Ile Lys Val Leu 435 440 445 Gly Arg Glu Lys Lys Arg Asn Ala Leu Ser Ala Ser Glu Ser Arg Ala 450 455 460 Leu Tyr Pro Glu Glu Lys Glu Ile Leu Ala Arg Glu Leu Ala Ile Lys 465 470 475 480 Glu Asn Met Lys Lys Ala Asp Val Leu Lys Leu Leu Phe Glu Asn Pro 485 490 495 Gin Glu Leu Asp Leu Asn Phe Lys Gin Ile Asp Gly Asn Arg Thr Gly 500 505 510 Phe Ser Leu Phe Ser Ala Tyr Ser Lys Met Ile Glu Lys Tyr Gly Tyr 515 520 525 Glu Pro Leu Asp Phe Lys Lys Pro Ala Asp Glu Ile Ile Gly Gin Leu 530 535 540 Arg Thr Ile Phe Thr Asp Leu Gly Trp Asn Thr Asn Leu Phe Thr Ile 545 550 555 560 Asp Leu Thr Lys Glu Gly Lys Glu Leu Glu Met Gin Pro Tyr Phe Arg 565 570 575 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Ser Thr Gly 580 585 590 Asn Gly Lys Leu Ile Glu Lys Ile Met Gin Leu Cys Gly Val Glu Lys 595 600 605 Glu Tyr Ala Val Glu Leu Ala Ser Leu Ser Phe Gin Asp Asp Tyr Gly 610 615 620 Ser Leu Ser Ala Lys Ala Ile Lys Arg Ile Leu Pro Tyr Leu Lys Glu 625 630 635 640 Page 1551 of 3790 Gly Asn Leu Tyr Asp Val Ala Cys Glu Tyr Ala Gly Tyr Arg His Ser 645 650 655 Lys Ser Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Gly 660 665 670 Lys Leu Glu Val Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 675 680 685 Lys Ile Leu Ser Gin Met Val Asn Val Ile Asn Thr Ile Ile Asp Thr 690 695 700 Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 705 710 715 720 Lys Ser Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Ile Ala Lys Ser 725 730 735 Thr Arg Glu His Glu Glu Ile Arg Lys Leu Leu Gin Asp Glu Phe Gly 740 745 750 Met Met Asn Val Ser Arg Asn Asp Ile Ile Arg Tyr Lys Leu Tyr Glu 755 760 765 Glu Leu Lys Asp Asn Gly Tyr Lys Thr Leu Tyr Ser Asn Gin Tyr Ile 770 775 780 Pro Lys Glu Lys Ile Phe Ser Lys Glu Ile Asp Ile Glu His Ile Ile 785 790 795 800 Pro Gin Ser Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Leu Glu 805 810 815 Tyr Lys Ala Ile Asn Ile Glu Lys Gly Asn Lys Thr Ala Tyr Asp Phe 820 825 830 Val Lys Glu Lys Tyr Gly Glu Glu Gly Leu Gin Gin Tyr Ile Asn Arg 835 840 845 Cys Glu Ser Leu Phe Asn Asp Lys Lys Ala Lys Leu Arg Lys Leu Lys 850 855 860 Met Glu Gin Lys Asp Ile Pro Asp Gly Phe Ile Asp Arg Asp Leu Arg 865 870 875 880 Asn Thr Gin Tyr Ile Ala Lys Lys Ala Leu Ala Met Leu Asn Glu Ile 885 895 Page 1552 of 3790 890 Page 1553 of 3790 Page 1554 of 3790 832 1055 PRT Bacteroides sp. 832 Met Arg Ile Tyr Arg Lys Asp Leu Ala Gin Asp Val Asp Val Thr Asn 15 10 15 Glu Leu Leu Lys Thr Glu Glu Asp Tyr Val Ala Leu Phe Asp Trp Leu 20 25 30 Asn Gly Lys Lys Glu Ile Asp Gin Lys Ala Phe Leu Lys Tyr Pro Leu 35 40 45 Phe Gly Leu Lys Lys Glu Val Glu Asn Tyr Arg Trp Asn Tyr Val Gin 50 55 60 Asp Lys Pro Tyr Pro Cys Asn Glu Thr Arg Ser Ser Met Leu Ala Arg 65 70 75 80 Leu Glu Lys Cys Asp Ile Ser Ile Glu Phe Leu Thr Lys Glu Asn Glu 85 90 95 Glu Ala Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Asn Glu Ile 100 105 110 Val Lys Ala Leu Gin Lys Phe Ala Asp Lys His Asp Leu Asn Ala Ser 115 120 125 Phe Val Asp Val Phe Gin Lys Phe Pro Pro Phe Lys Lys Glu Tyr Gly 130 135 140 Ser Tyr Ser Ala Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Met 145 150 155 160 Page 1555 of 3790 Gly Lys Tyr Trp Ser Glu Asn Ser Ile Asp Lys Gly Thr Arg Glu Arg 165 170 175 Met Asp Lys Ile Ile Thr Gly Glu Tyr Asp Glu Lys Ile Glu Asn Arg 180 185 190 Val Arg Glu Lys Ala Ile His Leu Ala Asp Val Ser Asp Phe Lys Gly 195 200 205 Leu Pro Leu Trp Leu Val Cys Tyr Ile Val Tyr Gly Arg His Ser Glu 210 215 220 Ala Lys Glu Ile Thr Gin Trp Lys Ser Pro Ala Asp Ile Asp Leu Tyr 225 230 235 240 Leu Arg Ser Phe Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin 245 250 255 Ile Ile Ile Glu Thr Leu Arg Val Val Arg Asp Ile Trp Lys Gin Val 260 265 270 Gly Asn Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu Met Lys Asn 275 280 285 Pro Ala Asp Lys Arg Lys Lys Met Thr Gin Gin Met Ser Glu Asn Glu 290 295 300 Asn Thr Asn Leu Arg Ile Lys Tyr Leu Leu Thr Glu Phe Leu Asn Pro 305 310 315 320 Glu Tyr Glu Val Glu Asn Val Arg Pro Tyr Ser Pro Ser Gin Gin Asp 325 330 335 Ile Leu Arg Ile Tyr Glu Glu Gly Val Leu Asn Ser Val Ser Asp Leu 340 345 350 Pro Glu Glu Ile Ser Asp Ile Leu Lys Lys Phe Thr Glu Thr Asp Leu 355 360 365 Lys Lys Arg Pro Ser Arg Ser Glu Val Leu Arg Tyr Lys Leu Trp Leu 370 375 380 Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Glu Val Ile Pro Leu Gly 385 390 395 400 Lys Leu Phe Thr Pro Ala Tyr Glu Ile Glu His Val Ile Pro Gin Ser 405 410 415 Page 1556 of 3790 Cys Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala Glu 420 425 430 Val Asn Lys Leu Lys Ser Asn Leu Leu Gly His Glu Phe Ile Val Lys 435 440 445 His His Gly Glu Ile Val Glu Leu Pro Phe Gly Lys Lys Val Arg Ile 450 455 460 Phe Thr Val Asp Glu Tyr Glu Gin Phe Val Lys Asp Asn Tyr Ser Arg 465 470 475 480 Thr Arg Ser Lys Met Lys Lys Leu Leu Met Asp Asp Ile Pro Glu Glu 485 490 495 Phe Val Ala Arg Gin Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val Val 500 505 510 Lys Ser Leu Leu Ser Asn Ile Val Arg Glu Lys Gly Glu Glu Glu Ala 515 520 525 Ile Ser Lys Asn Val Ile Pro Cys Thr Gly Gly Val Thr Asp Arg Leu 530 535 540 Lys Lys Asp Trp Gly Ile Asn Glu Val Trp Asn Lys Ile Ile Leu Pro 545 550 555 560 Arg Phe Gin Arg Leu Asn Glu Leu Thr Gly Thr Asn Lys Phe Thr Thr 565 570 575 Lys Asn Val Gly Ile Gin Glu Ile Pro Thr Met Pro Leu Glu Leu Gin 580 585 590 Lys Gly Phe Asn Lys Lys Arg Ile Asp His Arg His His Ala Met Asp 595 600 605 Ala Ile Ile Ile Ala Cys Ala Asn Arg Asn Ile Ile Asn Tyr Leu Asn 610 615 620 Asn Glu Ser Ala Thr Ala Lys Ala Glu Leu Ser Arg Tyr Asp Leu Gin 625 630 635 640 Lys Met Leu Cys Asp Lys Ala Lys Thr Asp Asn Asn Gly Asn Tyr Lys 645 650 655 Trp Val Ile Arg Lys Pro Trp Ala Ser Phe Thr Gin Asp Thr Tyr Leu Page 1558 of 3790 Lys Lys 1055 833 1055 PRT Bacteroides sp. 833 Met Arg Ile Tyr Arg Lys Asp Leu Ala Gin Asp Val Asp Val Thr Asn 15 10 15 Glu Leu Leu Lys Thr Glu Glu Asp Tyr Val Ala Leu 25 Phe Asp 30 Trp Leu Asn Gly Lys Lys Glu Ile Asp Gin Lys Ala Phe Leu Lys 35 40 45 Tyr Pro Val Phe Gly Leu Lys Lys Glu Ile Glu Asn Tyr Arg Trp Asn Tyr Val Gin 50 55 60 Page 1559 of 3790 Asp Lys Pro Tyr Pro Cys Asn Glu Thr Arg Ser Leu Met Leu Ala Arg 65 70 75 80 Leu Glu Lys Cys Asp Ile Ser Ile Glu Phe Leu Thr Lys Glu Asn Glu 85 90 95 Glu Ala Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Asn Glu Ile 100 105 110 Val Lys Ala Leu Gin Lys Phe Ala Asp Lys His Asp Leu Asn Ala Ser 115 120 125 Phe Val Asp Val Phe Gin Lys Phe Pro Pro Phe Lys Lys Glu Tyr Gly 130 135 140 Ser Tyr Ser Ala Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Met 145 150 155 160 Gly Lys Tyr Trp Ser Glu Asn Ser Ile Asp Lys Gly Thr Arg Glu Arg 165 170 175 Ile Asp Lys Ile Ile Thr Gly Glu Tyr Asp Glu Lys Ile Glu Asn Arg 180 185 190 Val Arg Glu Lys Ala Ile His Leu Ala Asp Val Ser Asp Phe Lys Gly 195 200 205 Leu Pro Leu Trp Leu Val Cys Tyr Ile Val Tyr Gly Arg His Ser Glu 210 215 220 Ala Lys Glu Ile Ile Gin Trp Lys Ser Pro Ala Asp Ile Asp Ser Tyr 225 230 235 240 Leu Arg Ser Phe Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin 245 250 255 Ile Ile Ile Glu Thr Leu Arg Val Val Arg Asp Ile Trp Lys Gin Val 260 265 270 Gly Asn Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu Met Lys Asn 275 280 285 Pro Ala Asp Lys Arg Lys Lys Met Thr Gin Gin Met Ser Glu Asn Glu 290 295 300 Asn Thr Asn Leu Arg Ile Lys Tyr Leu Leu Thr Glu Phe Leu Asn Pro 305 310 315 320 Page 1560 of 3790 Glu Tyr Glu Val Glu Asn Val Arg Pro Tyr Ser Pro Ser Gin Gin Asp 325 330 335 Ile Leu Arg Ile Tyr Glu Glu Gly Val Leu Asn Ser Val Ser Asp Leu 340 345 350 Pro Glu Glu Ile Ser Asp Ile Leu Lys Lys Phe Thr Glu Thr Asp Leu 355 360 365 Lys Lys Arg Pro Ser Arg Ser Glu Val Leu Arg Tyr Lys Leu Trp Leu 370 375 380 Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Glu Val Ile Pro Leu Gly 385 390 395 400 Lys Leu Phe Thr Pro Ala Tyr Glu Ile Glu His Val Ile Pro Gin Ser 405 410 415 Cys Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala Glu 420 425 430 Val Asn Lys Leu Lys Ser Asn Leu Leu Gly His Glu Phe Ile Val Lys 435 440 445 His His Gly Glu Ile Val Glu Leu Pro Phe Gly Lys Lys Val Arg Ile 450 455 460 Phe Thr Val Asp Glu Tyr Glu Gin Phe Val Lys Asp Asn Tyr Ser Arg 465 470 475 480 Thr Arg Ser Lys Met Lys Lys Leu Leu Met Asp Asp Ile Pro Glu Glu 485 490 495 Phe Val Thr Arg Gin Leu Asn Asp Ser Arg Tyr Ile Ser Lys Val Val 500 505 510 Lys Ser Leu Leu Ser Asn Ile Val Arg Glu Lys Gly Glu Glu Glu Ala 515 520 525 Ile Ser Lys Asn Val Ile Pro Cys Thr Gly Gly Val Thr Asp Arg Leu 530 535 540 Lys Lys Asp Trp Gly Ile Asn Glu Val Trp Asn Lys Ile Ile Leu Pro 545 550 555 560 Arg Phe Gin Arg Leu Asn Glu Leu Thr Gly Thr Asn Lys Phe Thr Thr 565 570 575 Page 1561 of 3790 Lys Asn Val Gly Ile Gin Glu Ile Pro Thr Met Pro Leu Glu Leu Gin 580 585 590 Lys Gly Phe Asn Lys Lys Arg Ile Asp His Arg His His Ala Met Asp 595 600 605 Ala Ile Ile Ile Ala Cys Ala Asn Arg Asn Ile Ile Asn Tyr Leu Asn 610 615 620 Asn Glu Ser Ala Thr Ala Lys Ala Glu Leu Ser Arg Tyr Asp Leu Gin 625 630 635 640 Lys Met Leu Cys Asp Lys Ala Lys Thr Asp Asn Asn Gly Asn Tyr Lys 645 650 655 Trp Val Ile Arg Lys Pro Trp Ala Ser Phe Thr Gin Asp Thr Tyr Leu 660 665 670 Ala Leu Glu Asn Ile Ile Val Ser Phe Lys Gin Asn Leu Arg Val Ile 675 680 685 Asn Lys Ala Thr Asn Arg Phe Leu His Tyr Asn Glu Glu Gly Lys Lys 690 695 700 Ile Phe Val Lys Gin Gly Lys Gly Asp Asn Trp Ala Ile Arg Lys Ser 705 710 715 720 Met His Lys Asp Thr Val Phe Gly Glu Val Asn Leu Arg Arg Ile Lys 725 730 735 Thr Val Ala Leu Asn Glu Ala Met Lys Asn Pro Gin Ser Ile Val Val 740 745 750 Lys Asp Phe Lys Arg Lys Leu Leu Glu Leu Trp Asn Leu Gly Phe Asp 755 760 765 Ala Lys Arg Ile Lys Lys Tyr Phe Glu Asp Asn Arg Glu Thr Trp Ser 770 775 780 Asp Ile Asn Leu Ser Lys Ile Glu Val Tyr Tyr Phe Ser Lys Asp Thr 785 790 795 800 Lys Asp Arg Phe Phe Ala Thr Arg Lys Pro Leu Asp Thr Ser Phe Asp 805 810 815 Arg Lys Lys Ile Glu Asn Asn Ile Thr Asp Thr Gly Ile Gin Lys Ile 820 830 Page 1562 of 3790 825 Lys Lys 1055 Page 1563 of 3790 834 286 PRT Bacteroides uniformis 834 Met Leu Ser Tyr Lys Tyr Asp Lys Lys Lys Ile Glu Lys Tyr Phe Lys 15 10 15 Glu Asn Ala Phe Leu Trp Lys Glu Leu Asp Ile Ala Lys Val Ala Val 20 25 30 Tyr Tyr Phe Thr Glu Asn Thr Thr Glu Pro Leu Val Ala Val Arg Lys 35 40 45 Ser Leu Asp Ser Thr Phe Asn Glu Lys Lys Ile Ala Ser Val Thr Asp 50 55 60 Thr Gly Ile Gin Lys Ile Leu Leu Asn His Leu Lys Ser Lys Glu Gly 65 70 75 80 Lys Ala Glu Leu Ala Phe Ser Ala Glu Gly Ile Glu Glu Met Asn Arg 85 90 95 Asn Leu Leu Gin Leu Asn Asp Gly Lys Gly His Gin Pro Ile Tyr Lys 100 105 110 Val Arg Val Tyr Glu Pro Arg Gly Asn Lys Phe Lys Val Gly Val Leu 115 120 125 Gly Asn Lys Gly Ala Lys Trp Val Glu Ala Ala Lys Gly Thr Asn Leu 130 135 140 Phe Phe Ala Ile Tyr Ile Thr Glu Asp Gly Asn Arg Thr Tyr Glu Thr 145 150 155 160 Ile Pro Leu Asn Trp Val Ile Glu Arg Glu Lys Gin Gly Leu Val Pro 165 170 175 Val Pro Asp Arg Asn Glu Lys Gly Asp Lys Leu Leu Phe Trp Leu Ser 180 185 190 Pro Asn Asp Leu Val Tyr Leu Pro Thr Glu Glu Glu Arg Asp Phe Gly 195 200 205 Arg Ile Asn Glu Pro Ile Asp Arg Gly Arg Ile Tyr Lys Met Val Ser 210 215 220 Page 1564 of 3790 Page 1565 of 3790 Thr Val Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 165 170 175 Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr 180 185 190 Tyr Gin Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 195 200 205 Glu Phe Tyr Ala Leu Lys Val Leu Ser Val Glu Ala Thr Asp Glu Lys 210 215 220 Lys Gly Arg Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val 225 230 235 240 Tyr Arg Arg Ser Ser Asn Val Pro Leu Asp Trp Glu Gly Arg Val Lys 245 250 255 Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Gly Thr Pro Lys Leu 260 265 270 Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 275 280 285 Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Thr Gly Thr 290 295 300 His Lys Thr Ile Gly Ser Tyr Ile Tyr Asp Ala Leu Leu Gin Glu Pro 305 310 315 320 Gin Gin Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Phe 325 330 335 Tyr Lys Glu Glu Leu Asn Phe Ile Leu Gin Lys Gin Cys Ala Phe His 340 345 350 Ala Glu Leu Gin Asp Arg Asp Leu Tyr Met Arg Cys Ile Glu Ala Leu 355 360 365 Tyr Pro Gly Asn Glu Val Gin Arg Arg Asn Ile Ala Asn Arg Asp Phe 370 375 380 Ile Tyr Leu Leu Ile Asp Asp Val Leu Phe Tyr Gin Arg Pro Leu Lys 385 390 395 400 Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 405 410 415 Page 1566 of 3790 Val Asn Arg Lys Thr Gly Glu Ile Lys Thr Ala Pro Leu Lys Cys Ile 420 425 430 Ala Lys Ser His Pro Leu Phe Gin Glu Phe Arg Leu Trp Tyr Phe Leu 435 440 445 Ser Asn Ile Arg Val Tyr Gin Lys Glu Arg Glu Val Asn Gly Thr Leu 450 455 460 His Leu Asp Val Asp Val Thr Thr Glu Phe Leu Lys Thr Glu Asp Asp 465 470 475 480 Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Asp Gin 485 490 495 Lys Ala Phe Leu Arg Tyr Pro Ala Phe Gly Leu Lys Lys Glu Ile Asn 500 505 510 Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Phe Tyr Pro Cys Asn Glu 515 520 525 Thr Arg His Ala Ile Leu Ser Arg Leu Glu Lys Ala Gly Ile Gly Ile 530 535 540 Asp Phe Leu Ser Asp Glu Lys Glu Thr Ala Leu Trp His Ile Leu Tyr 545 550 555 560 Ser Val Ser Asp Lys Gin Glu Ile Glu Lys Ala Leu Ala Thr Phe Ala 565 570 575 Val Lys Asn Gly Leu Asn Glu Ser Phe Val Glu Val Phe Lys Lys Phe 580 585 590 Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys 595 600 605 Lys Leu Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Met Ser Leu 610 615 620 Ile Asp Gly Thr Thr Lys Glu Arg Ile Glu Arg Ile Ile Ala Gly Glu 625 630 635 640 Cys Asp Glu Ser Ile Gly Ala Lys Val Arg Glu Lys Ala Met Asn Leu 645 650 655 Ser Asp Ile Ser Cys Phe Lys Arg Leu Pro Leu Trp Leu Ala Cys Tyr 660 665 670 Page 1567 of 3790 Val Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ile Thr Lys Trp Glu 675 680 685 Thr Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ala Phe Lys Gin His Ser 690 695 700 Leu Arg Asn Pro Ile Val Glu Gin Val Ile Thr Glu Thr Leu Arg Val 705 710 715 720 Val Arg Asp Ile Trp Lys Gin Val Gly Lys Ile Asp Glu Ile Arg Ile 725 730 735 Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 740 745 750 Thr Thr Gin Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 755 760 765 Leu Leu Ala Glu Phe Val Asn Pro Glu Tyr Gly Val Glu Asn Val Arg 770 775 780 Pro Tyr Ser Pro Ser Gin Gin Glu Ile Leu Arg Ile Tyr Glu Asp Ala 785 790 795 800 Val Leu Lys Gly Glu Glu Gin Ile Pro Glu Asp Ile Asp Val Ile Leu 805 810 815 Lys Lys Phe Asn Thr Ser Lys Leu Pro Thr Lys Ser Glu Phe Leu Arg 820 825 830 Tyr Lys Leu Trp Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 835 840 845 Leu Ile Pro Leu Ala Lys Leu Phe Thr Ala Ala Tyr Glu Ile Glu His 850 855 860 Val Ile Pro Gin Ser Arg Tyr Phe Asp Asp Ser Phe Ser Asn Lys Val 865 870 875 880 Ile Cys Glu Ser Ala Val Asn Lys Leu Lys Asp Asn Gin Leu Gly Tyr 885 890 895 Glu Phe Ile Lys Asn His His Gly Gin Lys Val Glu Val Gly Phe Gly 900 905 910 Lys Thr Val Glu Ile Phe Ser Val Asp Ser Tyr Glu Arg Phe Val Lys Page 1568 of 3790 Page 1569 of 3790 Page 1570 of 3790 1505 836 1210 PRT Bacteroides uniformis 836 Met Arg Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Val Ile Asn Ser Val Ile Lys Glu Gin Thr Glu Arg Ile Trp Ile 20 25 30 Glu Met Ala Gly Ser Arg Ile Ile Pro Met Asp Ala Ala Ile Leu Gly 35 40 45 Asp Phe Asp Lys Gly Asn Ser Ile Ser Gin Thr Ala Glu Arg Thr Arg 50 55 60 Phe Arg Gly Val Arg Arg Leu Arg Glu Arg Gin Leu Leu Arg Arg Glu 65 70 75 80 Arg Leu His Lys Val Leu Lys Ile Leu Gly Phe Leu Pro Glu His Tyr 85 90 95 Page 1571 of 3790 Leu Lys Gly Ile Asp Phe Glu Lys His Thr Gly Lys Phe Leu Ser Gly 100 105 110 Ser Glu Pro Lys Leu Pro Trp Val Lys Asp Arg Trp Gly Lys Tyr Ser 115 120 125 Phe Leu Phe Gin Thr Ala Phe Asn Glu Met Leu Ala Asp Phe Ala Lys 130 135 140 His Gin Pro Ser Leu Val Phe Asp Gly Lys Lys Ile Pro Tyr Asp Trp 145 150 155 160 Thr Val Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Glu Met Ile Ser Lys 165 170 175 Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr 180 185 190 Tyr Gin Leu Arg Gly Glu Glu Glu Glu Asp Asn Ala Gly Lys Ser Val 195 200 205 Glu Phe Tyr Ala Leu Lys Val Leu Ser Val Glu Ala Thr Asp Glu Lys 210 215 220 Lys Gly Arg Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val 225 230 235 240 Tyr Arg Arg Ser Ser Asn Val Pro Leu Asp Trp Glu Gly Arg Val Lys 245 250 255 Glu Phe Ile Val Thr Thr Asp Leu Asn Pro Asp Gly Thr Pro Lys Leu 260 265 270 Asp Lys Tyr Gly Glu Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp 275 280 285 Asp Trp Met Leu Ile Lys Lys Arg Thr Glu Ala Asp Ile Thr Gly Thr 290 295 300 His Lys Thr Ile Gly Ser Tyr Ile Tyr Asp Ala Leu Leu Gin Glu Pro 305 310 315 320 Gin Gin Lys Ile Ile Gly Lys Leu Val Lys Thr Val Glu Arg Lys Phe 325 330 335 Tyr Lys Glu Glu Leu Asn Phe Ile Leu Gin Lys Gin Cys Ala Phe His 340 345 350 Page 1572 of 3790 Ala Glu Leu Gin Asp Arg Asp Leu Tyr Met Arg Cys Ile Glu Ala Leu 355 360 365 Tyr Pro Gly Asn Glu Val Gin Arg Arg Asn Ile Ala Asn Arg Asp Phe 370 375 380 Ile Tyr Leu Leu Ile Asp Asp Val Leu Phe Tyr Gin Arg Pro Leu Lys 385 390 395 400 Thr Lys Lys Ser Leu Ile Ala Asn Cys Pro Tyr Glu Glu Asn Glu Tyr 405 410 415 Val Asn Arg Lys Thr Gly Glu Ile Lys Thr Ala Pro Leu Lys Cys Ile 420 425 430 Ala Lys Ser His Pro Leu Phe Gin Glu Phe Arg Leu Trp Tyr Phe Leu 435 440 445 Ser Asn Ile Arg Val Tyr Gin Lys Glu Arg Glu Val Asn Gly Thr Leu 450 455 460 His Leu Asp Val Asp Val Thr Thr Glu Phe Leu Lys Thr Glu Asp Asp 465 470 475 480 Tyr Val Ala Leu Phe Asp Trp Leu Asn Ser Arg Lys Glu Ile Asp Gin 485 490 495 Lys Ala Phe Leu Arg Tyr Pro Ala Phe Gly Leu Lys Lys Glu Ile Asn 500 505 510 Asn Tyr Arg Trp Asn Tyr Val Glu Asp Lys Phe Tyr Pro Cys Asn Glu 515 520 525 Thr Arg His Ala Ile Leu Ser Arg Leu Glu Lys Ala Gly Ile Gly Ile 530 535 540 Asp Phe Leu Ser Asp Glu Lys Glu Thr Ala Leu Trp His Ile Leu Tyr 545 550 555 560 Ser Val Ser Asp Lys Gin Glu Ile Glu Lys Ala Leu Ala Thr Phe Ala 565 570 575 Val Lys Asn Gly Leu Asn Glu Ser Phe Val Glu Val Phe Lys Lys Phe 580 585 590 Pro Pro Phe Lys Ser Glu Tyr Gly Ala Tyr Ser Ala Lys Ala Ile Lys Page 1573 of 3790 595 600 605 Lys Leu Leu Pro Leu Met Arg Cys Gly Lys Tyr Trp Asp Met Ser Leu 610 615 620 Ile Asp Gly Thr Thr Lys Glu Arg Ile Glu Arg Ile Ile Ala Gly Glu 625 630 635 640 Cys Asp Glu Ser Ile Gly Ala Lys Val Arg Glu Lys Ala Met Asn Leu 645 650 655 Ser Asp Ile Ser Cys Phe Lys Arg Leu Pro Leu Trp Leu Ala Cys Tyr 660 665 670 Val Val Tyr Asn Arg His Ser Glu Asp Lys Glu Ile Thr Lys Trp Glu 675 680 685 Thr Pro Ala Asp Ile Asp Ala Tyr Leu Ala Ala Phe Lys Gin His Ser 690 695 700 Leu Arg Asn Pro Ile Val Glu Gin Val Ile Thr Glu Thr Leu Arg Val 705 710 715 720 Val Arg Asp Ile Trp Lys Gin Val Gly Lys Ile Asp Glu Ile Arg Ile 725 730 735 Glu Leu Gly Arg Glu Met Lys Asn Pro Ala Asp Lys Arg Lys Arg Met 740 745 750 Thr Thr Gin Ile Leu Glu Asn Glu Asn Ala Asn Leu Arg Ile Lys Ala 755 760 765 Leu Leu Ala Glu Phe Val Asn Pro Glu Tyr Gly Val Glu Asn Val Arg 770 775 780 Pro Tyr Ser Pro Ser Gin Gin Glu Ile Leu Arg Ile Tyr Glu Asp Ala 785 790 795 800 Val Leu Lys Gly Glu Glu Gin Ile Pro Glu Asp Ile Asp Val Ile Leu 805 810 815 Lys Lys Phe Asn Thr Ser Lys Leu Pro Thr Lys Ser Glu Phe Leu Arg 820 825 830 Tyr Lys Leu Trp Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Glu 835 840 845 Page 1574 of 3790 Page 1575 of 3790 1205 1210 837 1504 PRT Bacteroides vulgatus 837 Met Lys Asn Ile Val Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Val Val Asn Gly Ser Val Asn Asp Asp Gly Ser Glu Gin Leu Val 20 25 30 Lys Ile Gin Ala 35 Ser Gly Ser Arg 40 Ile Ile Pro Met Asp Ala Ala Met 45 Ile Gly Asp Phe Asn Lys 50 Gly Asn 55 Ser Ile Ser Gin 60 Thr Ala Glu Arg Thr Arg Leu Arg 65 Gly Val 70 Arg Arg Leu Ser Glu Arg Tyr Leu 75 Leu Arg 80 Arg Glu Arg Leu His Arg Ile Leu Asp Ile Leu Gly Phe Leu Pro Phe 85 90 95 Page 1576 of 3790 His Phe Ala Gin Asp Leu Asp Arg His Gly Lys Ile Val Lys Gly Lys 100 105 110 Glu Pro Lys Leu Ala Trp Arg Lys Asn Glu Ala Gly Gin Phe Glu Phe 115 120 125 Ile Phe Gin Asp Ser Phe Lys Glu Met Leu Glu Asp Phe Lys Leu Asn 130 135 140 His Pro Asn Leu Ile Thr Asp Asp Lys Lys Val Pro Tyr Asp Trp Thr 145 150 155 160 Ile Tyr Tyr Leu Arg Lys Lys Gly Leu Thr Ser Lys Ile Ser Lys Glu 165 170 175 Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr 180 185 190 Gin Leu Arg Gly Glu Glu Glu Glu Glu Asn Lys Asn Lys Leu Val Glu 195 200 205 Phe Tyr Ala Leu Lys Val Val Ala Val Glu Asp Ser Gly Glu Lys Lys 210 215 220 Gly Lys Asp Ile Trp Tyr Asn Val His Leu Glu Asn Gly Trp Val Tyr 225 230 235 240 Arg Arg Thr Ser Asn Met Pro Leu Asp Trp Val Gly Lys Thr Lys Glu 245 250 255 Phe Ile Val Thr Thr Asp Leu Glu Lys Asp Gly Thr Pro Lys Lys Asp 260 265 270 Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ala Pro Lys Glu Asp Asp 275 280 285 Trp Ser Leu Leu Lys Lys Lys Thr Glu Ala Asp Ile Asp Gin Thr His 290 295 300 Lys Thr Val Gly Val Tyr Ile Tyr Asp Thr Leu Leu Gly Asn Pro Ser 305 310 315 320 Gin Lys Ile Arg Gly Arg Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 325 330 335 Lys Glu Glu Leu Lys Gin Ile Leu Glu Lys Gin Lys Glu Phe His Leu 340 345 350 Page 1577 of 3790 Glu Leu Gin Asp Arg Ala Leu Tyr Ala Ala Cys Ile Glu Glu Leu Tyr 355 360 365 Pro Ile Asn Glu Ala His Arg Asn Asn Val Gly Asn Arg Asp Phe Thr 370 375 380 Tyr Leu Phe Leu Glu Asp Ile Leu Phe Tyr Gin Arg Pro Leu Lys Ser 385 390 395 400 Lys Lys Ser Leu Ile Asp Asn Cys Pro Tyr Glu Glu Asn Gin Gly Leu 405 410 415 Asp Lys Glu Thr Gly Glu Ile Lys Ser Phe Pro Val Lys Cys Ile Ala 420 425 430 Lys Ser His Pro Leu Phe Gin Glu Phe Arg Leu Trp Gin Phe Ile Val 435 440 445 Asn Leu Arg Ile Tyr Arg Lys Asp Leu Ala Gin Asp Val Asp Val Thr 450 455 460 Asn Glu Leu Leu Lys Thr Glu Glu Asp Tyr Val Ala Leu Phe Asp Trp 465 470 475 480 Leu Asn Gly Lys Lys Glu Ile Asp Gin Lys Ala Phe Leu Lys Tyr Pro 485 490 495 Val Phe Gly Leu Lys Lys Glu Ile Glu Asn Tyr Arg Trp Asn Tyr Val 500 505 510 Gin Asp Lys Pro Tyr Pro Cys Asn Glu Thr Arg Ser Leu Met Leu Ala 515 520 525 Arg Leu Glu Lys Cys Asp Ile Ser Ile Glu Phe Leu Thr Lys Glu Asn 530 535 540 Glu Glu Ala Leu Trp His Ile Leu Tyr Ser Val Glu Asp Lys Asn Glu 545 550 555 560 Ile Val Lys Ala Leu Gin Lys Phe Ala Asp Lys His Asp Leu Asn Ala 565 570 575 Ser Phe Val Asp Val Phe Gin Lys Phe Pro Pro Phe Lys Lys Glu Tyr 580 585 590 Gly Ser Tyr Ser Ala Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Page 1578 of 3790 595 600 605 Met Gly Lys Tyr Trp Ser Glu Asn Ser Ile Asp Lys Gly Thr Arg Glu 610 615 620 Arg Ile Asp Lys Ile Ile Thr Gly Glu Tyr Asp Glu Lys Ile Glu Asn 625 630 635 640 Arg Val Arg Glu Lys Ala Ile His Leu Ala Asp Val Ser Asp Phe Lys 645 650 655 Gly Leu Pro Leu Trp Leu Val Cys Tyr Ile Val Tyr Gly Arg His Ser 660 665 670 Glu Ala Lys Glu Ile Thr Gin Trp Lys Ser Pro Ala Asp Ile Asp Ser 675 680 685 Tyr Leu Arg Ser Phe Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu 690 695 700 Gin Ile Ile Ile Glu Thr Leu Arg Val Val Arg Asp Ile Trp Lys Gin 705 710 715 720 Val Gly Asn Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu Met Lys 725 730 735 Asn Pro Ala Asp Lys Arg Lys Lys Met Thr Gin Gin Met Ser Glu Asn 740 745 750 Glu Asn Thr Asn Leu Arg Ile Lys Tyr Leu Leu Thr Glu Phe Leu Asn 755 760 765 Pro Glu Tyr Glu Val Glu Asn Val Arg Pro Tyr Ser Pro Ser Gin Gin 770 775 780 Asp Ile Leu Arg Ile Tyr Glu Glu Gly Val Leu Asn Ser Val Ser Asp 785 790 795 800 Leu Pro Glu Glu Ile Ser Asp Ile Leu Lys Lys Phe Thr Glu Thr Asp 805 810 815 Leu Lys Lys Arg Pro Ser Arg Ser Glu Ile Leu Arg Tyr Lys Leu Trp 820 825 830 Leu Glu Gin Lys Tyr Arg Ser Pro Tyr Thr Gly Glu Val Ile Pro Leu 835 840 845 Page 1579 of 3790 Ser Arg Tyr Asp Leu Gin Lys Met Leu Cys Asp Lys Ala Lys Thr 1085 1090 1095 Page 1580 of 3790 Page 1581 of 3790 Lys 838 1153 PRT Barnesiella intestinihominis 838 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Leu Ser Ser Ile Gly Trp 15 10 15 Ser Val Ile Arg Glu Asn Ser Glu Glu Gin Glu Leu Val Ala Met Gly 20 25 30 Page 1582 of 3790 Ser Arg Val Val Ser Leu Thr Ala Ala Glu Leu Ser Ser Phe Thr Gin 35 40 45 Gly Asn Gly Val Ser Ile Asn Ser Gin Arg Thr Gin Lys Arg Thr Gin 50 55 60 Arg Lys Gly Tyr Asp Arg Tyr Gin Leu Arg Arg Thr Leu Leu Arg Asn 65 70 75 80 Lys Leu Asp Thr Leu Gly Met Leu Pro Asp Asp Ser Leu Ser Tyr Leu 85 90 95 Pro Lys Leu Gin Leu Trp Gly Leu Arg Ala Lys Ala Val Thr Gin Arg 100 105 110 Ile Glu Leu Asn Glu Leu Gly Arg Val Leu Leu His Leu Asn Gin Lys 115 120 125 Arg Gly Tyr Lys Ser Ile Lys Ser Asp Phe Ser Gly Asp Lys Lys Ile 130 135 140 Thr Asp Tyr Val Lys Thr Val Lys Thr Arg Tyr Asp Glu Leu Lys Glu 145 150 155 160 Met Arg Leu Thr Ile Gly Glu Leu Phe Phe Arg Arg Leu Thr Glu Asn 165 170 175 Ala Phe Phe Arg Cys Lys Glu Gin Val Tyr Pro Arg Gin Ala Tyr Val 180 185 190 Glu Glu Phe Asp Cys Ile Met Asn Cys Gin Arg Lys Phe Tyr Pro Asp 195 200 205 Ile Leu Thr Asp Glu Thr Ile Arg Cys Ile Arg Asp Glu Ile Ile Tyr 210 215 220 Tyr Gin Arg Pro Leu Lys Ser Cys Lys Tyr Leu Val Ser Arg Cys Glu 225 230 235 240 Phe Glu Lys Arg Phe Tyr Leu Asn Ala Ala Gly Lys Lys Thr Glu Ala 245 250 255 Gly Pro Lys Val Ser Pro Arg Thr Ser Pro Leu Phe Gin Val Cys Arg 260 265 270 Leu Trp Glu Ser Ile Asn Asn Ile Val Val Lys Asp Arg Arg Asn Glu Page 1583 of 3790 275 280 285 Ile Val Phe Ile Ser Ala Glu Gin Arg Ala Ala Leu Phe Asp Phe Leu 290 295 300 Asn Thr His Glu Lys Leu Lys Gly Ser Asp Leu Leu Lys Leu Leu Gly 305 310 315 320 Leu Ser Lys Thr Tyr Gly Tyr Arg Leu Gly Glu Gin Phe Lys Thr Gly 325 330 335 Ile Gin Gly Asn Lys Thr Arg Val Glu Ile Glu Arg Ala Leu Gly Asn 340 345 350 Tyr Pro Asp Lys Lys Arg Leu Leu Gin Phe Asn Leu Gin Glu Glu Ser 355 360 365 Ser Ser Met Val Asn Thr Glu Thr Gly Glu Ile Ile Pro Met Ile Ser 370 375 380 Leu Ser Phe Glu Gin Glu Pro Leu Tyr Arg Leu Trp His Val Leu Tyr 385 390 395 400 Ser Ile Asp Asp Arg Glu Gin Leu Gin Ser Val Leu Arg Gin Lys Phe 405 410 415 Gly Ile Asp Asp Asp Glu Val Leu Glu Arg Leu Ser Ala Ile Asp Leu 420 425 430 Val Lys Ala Gly Phe Gly Asn Lys Ser Ser Lys Ala Ile Arg Arg Ile 435 440 445 Leu Pro Phe Leu Gin Leu Gly Met Asn Tyr Ala Glu Ala Cys Glu Ala 450 455 460 Ala Gly Tyr Asn His Ser Asn Asn Tyr Thr Lys Ala Glu Asn Glu Ala 465 470 475 480 Arg Ala Leu Leu Asp Arg Leu Pro Ala Ile Lys Lys Asn Glu Leu Arg 485 490 495 Gin Pro Val Val Glu Lys Ile Leu Asn Gin Met Val Asn Val Val Asn 500 505 510 Ala Leu Met Glu Lys Tyr Gly Arg Phe Asp Glu Ile Arg Val Glu Leu 515 520 525 Page 1584 of 3790 Ala Arg Glu Leu Lys Gin Ser Lys Glu Glu Arg Ser Asn Thr Tyr Lys 530 535 540 Ser Ile Asn Lys Asn Gin Arg Glu Asn Glu Gin Ile Ala Lys Arg Ile 545 550 555 560 Val Glu Tyr Gly Val Pro Thr Arg Ser Arg Ile Gin Lys Tyr Lys Met 565 570 575 Trp Glu Glu Ser Lys His Cys Cys Ile Tyr Cys Gly Gin Pro Val Asp 580 585 590 Val Gly Asp Phe Leu Arg Gly Phe Asp Val Glu Val Glu His Ile Ile 595 600 605 Pro Lys Ser Leu Tyr Phe Asp Asp Ser Phe Ala Asn Lys Val Cys Ser 610 615 620 Cys Arg Ser Cys Asn Lys Glu Lys Asn Asn Arg Thr Ala Tyr Asp Tyr 625 630 635 640 Met Lys Ser Lys Gly Glu Lys Ala Leu Ser Asp Tyr Val Glu Arg Val 645 650 655 Asn Thr Met Tyr Thr Asn Asn Gin Ile Ser Lys Thr Lys Trp Gin Asn 660 665 670 Leu Leu Thr Pro Val Asp Lys Ile Ser Ile Asp Phe Ile Asp Arg Gin 675 680 685 Leu Arg Glu Ser Gin Tyr Ile Ala Arg Lys Ala Lys Glu Ile Leu Thr 690 695 700 Ser Ile Cys Tyr Asn Val Thr Ala Thr Ser Gly Ser Val Thr Ser Phe 705 710 715 720 Leu Arg His Val Trp Gly Trp Asp Thr Val Leu His Asp Leu Asn Phe 725 730 735 Asp Arg Tyr Lys Lys Val Gly Leu Thr Glu Val Ile Glu Val Asn His 740 745 750 Arg Gly Ser Val Ile Arg Arg Glu Gin Ile Lys Asp Trp Ser Lys Arg 755 760 765 Phe Asp His Arg His His Ala Ile Asp Ala Leu Thr Ile Ala Cys Thr 770 775 780 Page 1585 of 3790 Asp Arg Cys Arg Val Gly Ile Pro Ala Ile Val Thr Gin Pro Asp 1010 1015 1020 Thr Ile Trp Asp Asn Ile Leu Gin Arg Asn Asp Ile Ser Glu Asn 1025 1030 1035 Page 1586 of 3790 839 1352 PRT Belliella baltica 839 Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Trp 15 10 15 Ala Phe Ile Lys Glu Pro Glu Lys Asp Val Val Gly Ser Glu Ile Val 20 25 30 Asp Met Gly Val Arg Ile Val Pro Leu Ser Ser Asp Glu Glu Asn Asp 35 40 45 Phe Ala Lys Gly Asn Thr Ile Ser Ile Asn Ala Asp Arg Thr Leu Lys 50 55 60 Arg Gly Ala Arg Arg Asn Leu Gin Arg Phe Lys Gin Arg Arg Asn Ala 65 70 75 80 Leu Leu Glu Ile Phe Lys Glu Lys Lys Leu Ile Ser Thr Asn Phe Lys 85 90 95 Page 1587 of 3790 Tyr Ala Glu Asp Gly Pro Ser Ser Thr Phe Ser Thr Leu Asn Leu Arg 100 105 110 Ala Lys Ala Ala Lys Glu Lys Ile Glu Leu Gin Asp Leu Val Lys Val 115 120 125 Leu Leu Gin Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala 130 135 140 Lys Ser Glu Glu Asp Asp Gly Ser Ala Ile Asp Ser Met Gly Ile Ala 145 150 155 160 Lys Glu Leu Tyr Glu Asn Asp Leu Thr Pro Gly Gin Trp Val Tyr Glu 165 170 175 Ala Leu Gin Lys Gly Arg Lys Asn Val Pro Asp Phe Tyr Arg Ser Asp 180 185 190 Leu Gin Glu Glu Phe Lys Lys Ile Val Asn Tyr Gin Ser Glu Phe Phe 195 200 205 Pro Asp Ile Phe Asn Ala Ser Phe Val Glu Asp Trp Met Gly Lys Ala 210 215 220 Ser Thr Pro Thr Lys Gin Tyr Phe Asn Lys Lys Gly Val Gin Leu Ala 225 230 235 240 Glu Asn Lys Gly Lys Arg Glu Glu Arg Arg Leu Gin Glu Tyr Lys Trp 245 250 255 Arg Ala Glu Ala Val Asn Phe Lys Ile Asp Leu Ser Glu Ile Ala Leu 260 265 270 Ile Leu Ser Gin Ile Asn Ser Gin Ile Ser Asn Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Lys Asn Leu Thr 290 295 300 Val Gly Gin Tyr Leu Tyr Gin Gin Ile Lys Lys Asn Pro His Thr Arg 305 310 315 320 Leu Lys Gly Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Arg Ile Trp Ser Val Gin Ser Ser Phe Tyr Pro Gin Leu Asn Asp Ala 565 570 575 Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gin Ser Gly Leu 580 585 590 Page 1589 of 3790 Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 595 600 605 Phe Thr Lys Asp Glu Asn Glu Lys Arg Glu Leu Arg Ala Glu Leu Glu 610 615 620 Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 625 630 635 640 Asn Gin Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Glu Leu 645 650 655 Gly Arg Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 660 665 670 Asn Ala Glu Gin Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 675 680 685 Arg Asp His Asp Lys Tyr Arg Glu Ile Leu Lys Ser Glu Phe Gly Leu 690 695 700 Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 705 710 715 720 Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 725 730 735 Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Ala Arg 740 745 750 Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gin Leu 755 760 765 Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gin Asn Lys 770 775 780 Leu Ser Ala Asp Glu Phe Glu Gin Tyr Gin Ser Arg Val Lys Ser Leu 785 790 795 800 Tyr Gly Lys Leu Ser Lys Ala Lys Ile Gin Lys Leu Leu Met Ala Asn 805 810 815 Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gin Leu Gin Glu Thr Arg 820 825 830 Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Ser Arg Arg 835 840 845 Page 1590 of 3790 Asp Leu Gly Lys Asn Ile Lys Leu Ser Glu Lys Val Lys Thr Val 1085 1090 1095 Page 1591 of 3790 His Phe Tyr Gin Thr Pro Glu His Leu Arg Gly Ile Ile Lys Ile Page 1592 of 3790 1335 1325 1330 Arg Ile Asn His Leu Gly Lys Ile Ile Gin Ile Gly Glu Tyr 1340 1345 1350 840 1415 PRT Bergeyella zoohelcum 840 Met Lys His Ile Leu Gly Leu Asp 1 5 Leu Gly Thr Asn Ser Ile Gly Trp 10 15 Ala Leu Ile Glu Arg Asn Ile Glu 20 Glu Lys Tyr Gly Lys Ile Ile Gly 25 30 Met Gly Ser Arg Ile Val Pro Met 35 40 Gly Ala Glu Leu Ser Lys Phe Glu 45 Gin Gly Gin Ala Gin Thr Lys Asn 50 55 Ala Asp Arg Arg Thr Asn Arg Gly 60 Ala Arg Arg Leu Asn Lys Arg Tyr 65 70 Lys Gin Arg Arg Asn Lys Leu Ile 75 80 Tyr Ile Leu Gin Lys Leu Asp Met 85 Leu Pro Ser Gin Ile Lys Leu Lys 90 95 Glu Asp Phe Ser Asp Pro Asn Lys 100 Ile Asp Lys Ile Thr Ile Leu Pro 105 110 Ile Ser Lys Lys Gin Glu Gin Leu 115 120 Thr Ala Phe Asp Leu Val Ser Leu 125 Arg Val Lys Ala Leu Thr Glu Lys 130 135 Val Gly Leu Glu Asp Leu Gly Lys 140 Ile Ile Tyr Lys Tyr Asn Gin Leu 145 150 Arg Gly Tyr Ala Gly Gly Ser Leu 155 160 Glu Pro Glu Lys Glu Asp Ile Phe 165 Asp Glu Glu Gin Ser Lys Asp Lys 170 175 Lys Asn Lys Ser Phe Ile Ala Phe 180 Ser Lys Ile Val Phe Leu Gly Glu 185 190 Pro Gin Glu Glu Ile Phe Lys Asn Lys Lys Leu Asn Arg Arg Ala Ile Page 1593 of 3790 195 200 205 Ile Val Glu Thr Glu Glu Gly Asn Phe Glu Gly Ser Thr Phe Leu Glu 210 215 220 Asn Ile Lys Val Gly Asp Ser Leu Glu Leu Leu Ile Asn Ile Ser Ala 225 230 235 240 Ser Lys Ser Gly Asp Thr Ile Thr Ile Lys Leu Pro Asn Lys Thr Asn 245 250 255 Trp Arg Lys Lys Met Glu Asn Ile Glu Asn Gin Leu Lys Glu Lys Ser 260 265 270 Lys Glu Met Gly Arg Glu Phe Tyr Ile Ser Glu Phe Leu Leu Glu Leu 275 280 285 Leu Lys Glu Asn Arg Trp Ala Lys Ile Arg Asn Asn Thr Ile Leu Arg 290 295 300 Ala Arg Tyr Glu Ser Glu Phe Glu Ala Ile Trp Asn Glu Gin Val Lys 305 310 315 320 His Tyr Pro Phe Leu Glu Asn Leu Asp Lys Lys Thr Leu Ile Glu Ile 325 330 335 Val Ser Phe Ile Phe Pro Gly Glu Lys Glu Ser Gin Lys Lys Tyr Arg 340 345 350 Glu Leu Gly Leu Glu Lys Gly Leu Lys Tyr Ile Ile Lys Asn Gin Val 355 360 365 Val Phe Tyr Gin Arg Glu Leu Lys Asp Gin Ser His Leu Ile Ser Asp 370 375 380 Cys Arg Tyr Glu Pro Asn Glu Lys Ala Ile Ala Lys Ser His Pro Val 385 390 395 400 Phe Gin Glu Tyr Lys Val Trp Glu Gin Ile Asn Lys Leu Ile Val Asn 405 410 415 Thr Lys Ile Glu Ala Gly Thr Asn Arg Lys Gly Glu Lys Lys Tyr Lys 420 425 430 Tyr Ile Asp Arg Pro Ile Pro Thr Ala Leu Lys Glu Trp Ile Phe Glu 435 440 445 Page 1594 of 3790 Glu Leu Gin Asn Lys Lys Glu Ile Thr Phe Ser Ala Ile Phe Lys Lys 450 455 460 Leu Lys Ala Glu Phe Asp Leu Arg Glu Gly Ile Asp Phe Leu Asn Gly 465 470 475 480 Met Ser Pro Lys Asp Lys Leu Lys Gly Asn Glu Thr Lys Leu Gin Leu 485 490 495 Gin Lys Ser Leu Gly Glu Leu Trp Asp Val Leu Gly Leu Asp Ser Ile 500 505 510 Asn Arg Gin Ile Glu Leu Trp Asn Ile Leu Tyr Asn Glu Lys Gly Asn 515 520 525 Glu Tyr Asp Leu Thr Ser Asp Arg Thr Ser Lys Val Leu Glu Phe Ile 530 535 540 Asn Lys Tyr Gly Asn Asn Ile Val Asp Asp Asn Ala Glu Glu Thr Ala 545 550 555 560 Ile Arg Ile Ser Lys Ile Lys Phe Ala Arg Ala Tyr Ser Ser Leu Ser 565 570 575 Leu Lys Ala Val Glu Arg Ile Leu Pro Leu Val Arg Ala Gly Lys Tyr 580 585 590 Phe Asn Asn Asp Phe Ser Gin Gin Leu Gin Ser Lys Ile Leu Lys Leu 595 600 605 Leu Asn Glu Asn Val Glu Asp Pro Phe Ala Lys Ala Ala Gin Thr Tyr 610 615 620 Leu Asp Asn Asn Gin Ser Val Leu Ser Glu Gly Gly Val Gly Asn Ser 625 630 635 640 Ile Ala Thr Ile Leu Val Tyr Asp Lys His Thr Ala Lys Glu Tyr Ser 645 650 655 His Asp Glu Leu Tyr Lys Ser Tyr Lys Glu Ile Asn Leu Leu Lys Gin 660 665 670 Gly Asp Leu Arg Asn Pro Leu Val Glu Gin Ile Ile Asn Glu Ala Leu 675 680 685 Val Leu Ile Arg Asp Ile Trp Lys Asn Tyr Gly Ile Lys Pro Asn Glu 690 695 700 Page 1595 of 3790 Ile Arg Val Glu Leu Ala Arg Asp Leu Lys Asn Ser Ala Lys Glu Arg 705 710 715 720 Ala Thr Ile His Lys Arg Asn Lys Asp Asn Gin Thr Ile Asn Asn Lys 725 730 735 Ile Lys Glu Thr Leu Val Lys Asn Lys Lys Glu Leu Ser Leu Ala Asn 740 745 750 Ile Glu Lys Val Lys Leu Trp Glu Ala Gin Arg His Leu Ser Pro Tyr 755 760 765 Thr Gly Gin Pro Ile Pro Leu Ser Asp Leu Phe Asp Lys Glu Lys Tyr 770 775 780 Asp Val Asp His Ile Ile Pro Ile Ser Arg Tyr Phe Asp Asp Ser Phe 785 790 795 800 Thr Asn Lys Val Ile Ser Glu Lys Ser Val Asn Gin Glu Lys Ala Asn 805 810 815 Arg Thr Ala Met Glu Tyr Phe Glu Val Gly Ser Leu Lys Tyr Ser Ile 820 825 830 Phe Thr Lys Glu Gin Phe Ile Ala His Val Asn Glu Tyr Phe Ser Gly 835 840 845 Val Lys Arg Lys Asn Leu Leu Ala Thr Ser Ile Pro Glu Asp Pro Val 850 855 860 Gin Arg Gin Ile Lys Asp Thr Gin Tyr Ile Ala Ile Arg Val Lys Glu 865 870 875 880 Glu Leu Asn Lys Ile Val Gly Asn Glu Asn Val Lys Thr Thr Thr Gly 885 890 895 Ser Ile Thr Asp Tyr Leu Arg Asn His Trp Gly Leu Thr Asp Lys Phe 900 905 910 Lys Leu Leu Leu Lys Glu Arg Tyr Glu Ala Leu Leu Glu Ser Glu Lys 915 920 925 Phe Leu Glu Ala Glu Tyr Asp Asn Tyr Lys Lys Asp Phe Asp Ser Arg 930 935 940 Lys Lys Glu Tyr Glu Glu Lys Glu Val Leu Phe Glu Glu Gin Glu Leu 945 950 955 960 Page 1596 of 3790 Arg Asn Glu Lys Gly Glu Leu Lys Pro His Thr Pro Ile Ser Thr Lys Arg 1415 Page 1598 of 3790 841 1430 PRT Bergeyella zoohelcum 841 Page 1599 of 3790 Arg Ala Thr Ser Ala Leu Phe Leu Ala Lys Tyr Gin Ile Tyr Thr Ala 225 230 235 240 Glu Asn Lys Gly Ser Arg Glu Asp Lys Lys Leu Gin Ala Tyr Gin Trp 245 250 255 Arg Val Asp Ala Leu Ser Lys Glu Leu Thr Arg Glu Gin Leu Ala Phe 260 265 270 Val Ile Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Glu Thr 290 295 300 Val Gly Glu Tyr Leu Trp Lys Gin Ile Ala Ala Asn Pro His Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Gin Ile Trp Lys Thr Gin Ser Ala Phe Tyr Pro Glu Ile Leu Thr Asp 340 345 350 Glu Leu Lys Lys Glu Leu Arg Asp Val Val Ile Phe Tyr Gin Arg Lys 355 360 365 Leu Lys Ser Gin Lys Ser Leu Val Ser Phe Cys Glu Phe Glu Asn Lys 370 375 380 Glu Ile Glu Ile Lys Lys Glu Asp Gly Thr Ser Thr Lys Lys Val Ile 385 390 395 400 Gly Leu Lys Val Ala Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys 405 410 415 Ile Trp Gin Asn Leu Asn Asn Val Leu Ile Arg Lys Lys Gly Ser Lys 420 425 430 Thr Lys Lys Val Ala Lys Asn Gin Gin Ala Val Leu Phe Glu Glu Glu 435 440 445 Lys Thr Ile Ser Glu Leu Asp Leu Glu Ala Lys Gin Ala Leu Phe Asn 450 455 460 Glu Leu Asn Leu Lys Gly Asn Leu Lys Ala Asp Tyr Cys Leu Glu Ile 465 470 475 480 Page 1600 of 3790 Leu Gly Tyr Ser Pro Lys Glu Trp Glu Met Asn Tyr Ser Val Leu Glu 485 490 495 Gly Asn Arg Thr Asn Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Thr 500 505 510 Asp Leu Glu Gly Tyr Asp Ala Lys Asn His Leu Lys Val Lys Leu Asn 515 520 525 Lys Asp Glu Val Glu Leu Asp Asp Leu Lys Val Pro Ala Ser Glu Ile 530 535 540 Lys Asp Met Val Gin Ala Ile Phe Lys Glu Ala Gly Ile Asn Thr Asp 545 550 555 560 Ile Leu His Phe Asn Ala Glu Leu Asp Gly Lys Asp Phe Glu Asn Gin 565 570 575 Ala Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asp 580 585 590 Ser Lys Ser Gly Asn Glu Leu Leu Tyr Lys Leu Leu Glu Thr Lys Phe 595 600 605 Gly Phe Lys Lys Glu Tyr Ala Gin Ile Leu Ala Asn Val Ser Leu Ser 610 615 620 Asp Asp Tyr Gly Ser Leu Ser Thr Lys Ala Met Arg Lys Ile His Pro 625 630 635 640 Tyr Ile Lys Glu Asn Lys Phe Ser Thr Ala Cys Glu Leu Ala Gly Tyr 645 650 655 Arg His Ser Lys His Ser Leu Thr Lys Glu Glu Asn Asp Asn Arg Val 660 665 670 Leu Lys Asp Ser Leu Glu Val Leu Lys Lys Asn Ser Leu Arg Gin Pro 675 680 685 Val Val Glu Lys Ile Leu Asn Gin Met Ile Asn Leu Val Asn Ala Leu 690 695 700 Leu Lys Lys Tyr Arg Thr Glu Asn Pro Asn Phe Lys Phe Asp Glu Ile 705 710 715 720 Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn Ala Glu Glu Arg Ala 725 730 735 Page 1601 of 3790 Asn Met Thr Ala Asn Ile Asn Lys Ala Lys Thr Glu His Glu Lys Ile 740 745 750 Ile Lys Ile Leu Lys Asn Glu Phe Gly Leu Pro Asn Pro Thr Arg Asn 755 760 765 Asp Ile Ile Arg Tyr Arg Leu Tyr Glu Glu Leu Lys Ala Asn Gly Tyr 770 775 780 Lys Asp Leu Tyr Thr Asn Ile Lys Ile Pro Gin Glu Lys Leu Phe Thr 785 790 795 800 Lys Glu Ile Asp Ile Glu His Ile Ile Pro Lys Ser Arg Val Phe Asp 805 810 815 Asp Ser Phe Ser Asn Lys Thr Leu Ser Phe Arg Lys Thr Asn Leu Asp 820 825 830 Lys Gly Glu Arg Thr Ala Phe Asp Tyr Met Glu Ser Lys Phe Gly Ala 835 840 845 Asp Lys Leu Glu Glu Tyr Val Ala Arg Val Glu Asp Leu Tyr Lys Asn 850 855 860 Asn Ile Ile Ser Lys Ala Lys Tyr Gin Lys Leu Leu Lys Lys Glu Ser 865 870 875 880 Glu Ile Gly Asp Gly Phe Val Glu Arg Asp Leu Arg Glu Thr Gin Tyr 885 890 895 Ile Ala Lys Lys Ala Lys Glu Ile Leu Leu Gin Ile Thr Pro Asn Val 900 905 910 Leu Ser Thr Ser Gly Gly Ile Thr Asp Arg Leu Arg Glu Asp Trp Asp 915 920 925 Leu Ile Asn Val Met Lys Glu Leu Asn Leu Pro Lys Tyr Arg Ala Leu 930 935 940 Gly Leu Thr Gin Met Glu Asp Arg Lys Tyr Gly Gin Gin Val Glu Val 945 950 955 960 Ile Thr Asp Trp Thr Lys Arg Asn Asp His Arg His His Ala Met Asp 965 970 975 Ala Leu Thr Val Ala Phe Thr Lys His Asn His Ile Gin Tyr Leu Asn 980 990 Page 1602 of 3790 985 Tyr Leu Asn Ala Arg Lys Asn Glu Lys His Lys Glu His Ser Asn Ile 995 1000 1005 Page 1603 of 3790 Glu Tyr 1430 842 1281 PRT Page 1604 of 3790 Bifidobacterium bifidum 842 Met Glu Asp Asp Ser Gin His Asp Ile Arg Glu Ile Tyr Leu Ala Ile 15 10 15 His His Met Val Lys Tyr Arg Gly Asn Phe Leu Val Glu Gly Thr Leu 20 25 30 Glu Ser Ser Asn Ala Phe Lys Glu Asp Glu Leu Leu Lys Leu Leu Gly 35 40 45 Arg Ile Thr Arg Tyr Glu Met Ser Glu Gly Glu Gin Asn Ser Asp Ile 50 55 60 Glu Gin Asp Asp Glu Asn Lys Leu Val Ala Pro Ala Asn Gly Gin Leu 65 70 75 80 Ala Asp Ala Leu Cys Ala Thr Arg Gly Ser Arg Ser Met Arg Val Asp 85 90 95 Asn Ala Leu Glu Ala Leu Ser Ala Val Asn Asp Leu Ser Arg Glu Gin 100 105 110 Arg Ala Ile Val Lys Ala Ile Phe Ala Gly Leu Glu Gly Asn Lys Leu 115 120 125 Asp Leu Ala Lys Ile Phe Val Ser Lys Glu Phe Ser Ser Glu Asn Lys 130 135 140 Lys Ile Leu Gly Ile Tyr Phe Asn Lys Ser Asp Tyr Glu Glu Lys Cys 145 150 155 160 Val Gin Ile Val Asp Ser Gly Leu Leu Asp Asp Glu Glu Arg Glu Phe 165 170 175 Leu Asp Arg Met Gin Gly Gin Tyr Asn Ala Ile Ala Leu Lys Gin Leu 180 185 190 Leu Gly Arg Ser Thr Ser Val Ser Asp Ser Lys Cys Ala Ser Tyr Asp 195 200 205 Ala His Arg Ala Asn Trp Asn Leu Ile Lys Leu Gin Leu Arg Thr Lys 210 215 220 Glu Asn Glu Lys Asp Ile Asn Glu Asn Tyr Gly Ile Leu Val Gly Trp 225 230 235 240 Page 1605 of 3790 Lys Ile Asp Ser Gly Gin Arg Lys Ser Val Arg Gly Glu Ser Ala Tyr 245 250 255 Glu Asn Met Arg Lys Lys Ala Asn Val Phe Phe Lys Lys Met Ile Glu 260 265 270 Thr Ser Asp Leu Ser Glu Thr Asp Lys Asn Arg Leu Ile His Asp Ile 275 280 285 Glu Glu Asp Lys Leu Phe Pro Ile Gin Arg Asp Ser Asp Asn Gly Val 290 295 300 Ile Pro His Gin Leu His Gin Asn Glu Leu Lys Gin Ile Ile Lys Lys 305 310 315 320 Gin Gly Lys Tyr Tyr Pro Phe Leu Leu Asp Ala Phe Glu Lys Asp Gly 325 330 335 Lys Gin Ile Asn Lys Ile Glu Gly Leu Leu Ala Phe Arg Val Pro Tyr 340 345 350 Phe Val Gly Pro Leu Val Val Pro Glu Asp Leu Gin Lys Ser Asp Asn 355 360 365 Ser Glu Asn His Trp Met Val Arg Lys Lys Lys Gly Glu Ile Thr Pro 370 375 380 Trp Asn Phe Asp Glu Met Val Asp Lys Asp Ala Ser Gly Arg Lys Phe 385 390 395 400 Ile Glu Arg Leu Val Gly Thr Asp Ser Tyr Leu Leu Gly Glu Pro Thr 405 410 415 Leu Pro Lys Asn Ser Leu Leu Tyr Gin Glu Tyr Glu Val Leu Asn Glu 420 425 430 Leu Asn Asn Val Arg Leu Ser Val Arg Thr Gly Asn His Trp Asn Asp 435 440 445 Lys Arg Arg Met Arg Leu Gly Arg Glu Glu Lys Thr Leu Leu Cys Gin 450 455 460 Arg Leu Phe Met Lys Gly Gin Thr Val Thr Lys Arg Thr Ala Glu Asn 465 470 475 480 Leu Leu Arg Lys Glu Tyr Gly Arg Thr Tyr Glu Leu Ser Gly Leu Ser 485 490 495 Page 1606 of 3790 Asp Glu Ser Lys Phe Thr Ser Ser Leu Ser Thr Tyr Gly Lys Met Cys 500 505 510 Arg Ile Phe Gly Glu Lys Tyr Val Asn Glu His Arg Asp Leu Met Glu 515 520 525 Lys Ile Val Glu Leu Gin Thr Val Phe Glu Asp Lys Glu Thr Leu Leu 530 535 540 His Gin Leu Arg Gin Leu Glu Gly Ile Ser Glu Ala Asp Cys Ala Leu 545 550 555 560 Leu Val Asn Thr His Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 565 570 575 Leu Thr Thr Lys Ala Gly Glu Cys Lys Ile Ser Asp Asp Phe Ala Pro 580 585 590 Arg Lys His Ser Ile Ile Glu Ile Met Arg Ala Glu Asp Arg Asn Leu 595 600 605 Met Glu Ile Ile Thr Asp Lys Gin Leu Gly Phe Ser Asp Trp Ile Glu 610 615 620 Gin Glu Asn Leu Gly Ala Glu Asn Gly Ser Ser Leu Met Glu Val Val 625 630 635 640 Asp Asp Leu Arg Val Ser Pro Lys Val Lys Arg Gly Ile Ile Gin Ser 645 650 655 Ile Arg Leu Ile Asp Asp Ile Ser Lys Ala Val Gly Lys Arg Pro Ser 660 665 670 Arg Ile Phe Leu Glu Leu Ala Asp Asp Ile Gin Pro Ser Gly Arg Thr 675 680 685 Ile Ser Arg Lys Ser Arg Leu Gin Asp Leu Tyr Arg Asn Ala Asn Leu 690 695 700 Gly Lys Glu Phe Lys Gly Ile Ala Asp Glu Leu Asn Ala Cys Ser Asp 705 710 715 720 Lys Asp Leu Gin Asp Asp Arg Leu Phe Leu Tyr Tyr Thr Gin Leu Gly 725 730 735 Lys Asp Met Tyr Thr Gly Glu Glu Leu Asp Leu Asp Arg Leu Ser Ser 965 970 975 Glu Glu Asp Lys Asp Tyr Leu Arg Lys Val Met Asn Tyr Arg Lys Met 980 985 990 Page 1608 of 3790 Leu Val Thr Gin Lys Val Gly Asp Asp Phe Gly Ala Leu Tyr Asp Glu 995 1000 1005 Page 1609 of 3790 Ser Gin Pro 1280 843 1121 PRT Bifidobacterium dentium 843 Page 1610 of 3790 Gly Asn Pro Thr Ser Ala Glu Ile Val Glu Cys Ile Leu Lys Arg Gin 165 170 175 Val Gly Glu Val Gin Leu Arg Thr Arg Ser Arg Lys Gly Val Asn Gly 180 185 190 Asn Ala Val Glu Lys Glu Gly Leu Leu Pro Thr Lys Leu Met Gin Ser 195 200 205 Asp Asn Ala Ala Glu Ile Arg Arg Ile Phe Lys Val Gin Arg Ile Asp 210 215 220 Asp Glu Thr Gly Arg Lys Leu Leu Arg Ala Val Phe Lys Ala Cys Ser 225 230 235 240 Pro Lys Gly Ser Val Glu Arg Arg Val Gly Arg Asp Ala Leu Ala Pro 245 250 255 Gly Leu Pro Arg Ala Leu Lys Ala Ser Leu Ala Phe Gin Glu Tyr Arg 260 265 270 Ile Ala Asn Val Leu Thr Asn Leu Val Ile Ser Glu Asp Gly Thr Lys 275 280 285 Arg Lys Leu Thr Ile Ala Glu Lys Gin Arg Val Phe Gly Phe Leu Ser 290 295 300 Ser Asn Glu Thr Asp Asp Ile Thr Trp Ile Asp Val Ala Glu Lys Leu 305 310 315 320 Gly Leu Glu Arg Arg Gin Ile Gin Gly Val Gly Cys Leu Thr Ala Asp 325 330 335 Gly Glu Glu Arg Ile Ser Ser Thr Pro Pro Arg Asn Ile Thr Ala Leu 340 345 350 His Ile His Ser Ala Lys Pro Val Ile Arg Glu Lys Leu Val Ala Trp 355 360 365 Trp Lys Ala Ala Ser Pro Thr Val Arg Glu Thr Met Val Glu Leu Leu 370 375 380 Ser Asn Thr Val Asp Ile Asp Arg Val Arg Glu Asp Met Asp Tyr Ser 385 390 395 400 Ser Ala Val Ala Phe Ile Asp Ser Leu Gly Asp Glu Glu Leu Thr Ala 405 410 415 Page 1611 of 3790 Leu Asp Ser Val Asp Leu Leu Ser Gly Arg Ala Ala Tyr Ser Arg Gin 420 425 430 Thr Leu Lys Gin Leu Thr Glu Arg Met Leu Asn Thr Asp Asp Asp Leu 435 440 445 His Glu Ala Arg Lys Ala Val Phe Gly Val Asp Asp Asn Trp Lys Pro 450 455 460 Pro Val Asp Ala Ile Ser Thr Ser Val Gly Asn Pro Ala Val Asp Arg 465 470 475 480 Val Leu Lys Ile Val Asn Arg Tyr Leu Leu Ala Cys Gin Lys Arg Trp 485 490 495 Arg Asn Pro Gin Ser Val Gin Ile Glu His Val Arg Glu Ser Phe Ser 500 505 510 Ser Val Ala Lys Ala Lys Glu Thr Glu Arg Val Gin Gly Glu Arg Ala 515 520 525 Arg Tyr Arg Asn Asp Leu Arg Arg Glu Leu Cys Glu Gin Glu Gly Leu 530 535 540 Asn Lys Ile Arg Glu Ser Asp Ile Arg Arg Trp Glu Ser Val Gin Arg 545 550 555 560 Gin Asn Gly Thr Cys Leu Tyr Cys Gly Ser Pro Ile Thr Phe Arg Thr 565 570 575 Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn 580 585 590 Thr Arg Val Asn Leu Ala Ala Ala Cys Ala Ala Cys Asn Lys Leu Lys 595 600 605 Ser Asn Thr Ala Phe Ser Val Trp Ala Arg Thr Glu Gly Ala Ala Asn 610 615 620 Arg Lys Val Ser Gin Arg Asp Ala Ile Glu Arg Val Lys Thr Phe Ile 625 630 635 640 Phe Asn Lys Ser Val Pro Pro Arg Glu Gin Arg Ala Phe Lys Gin Ala 645 650 655 Val Ile Ser Arg Leu Arg Gin Ala Glu Ser Asp Pro Ala Ile Asp Asn 885 890 895 Ser Thr Glu Thr Val Asp Phe Phe Ala Ser Gly Ala Ala Gin Leu Met 900 905 910 Page 1613 of 3790 844 354 PRT Bifidobacterium longum 844 Page 1614 of 3790 Ala Lys Gin Tyr Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu 15 10 15 Thr Met Lys Thr Thr Val Ser Val Phe Gin Gly Arg Val Thr Ala Ser 20 25 30 Ala Arg Arg Ala Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gin 35 40 45 Gin Ser Lys Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser 50 55 60 Val Ile Ala Met Met Asn Thr Ala Ala Ala Gin Thr Leu Met Glu Arg 65 70 75 80 Glu Ser Leu Arg Glu Ser Gin Arg Leu Ile Gly Leu Met Pro Gly Glu 85 90 95 Arg Ser Trp Lys Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu Ser 100 105 110 Phe His Leu Trp Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Asn 115 120 125 Asp Ala Leu Asp Asn Asp Arg Ile Ala Val Met Gin Ser Gin Arg Tyr 130 135 140 Val Leu Gly Asn Ser Ile Ala His Asp Ala Thr Ile His Pro Leu Glu 145 150 155 160 Lys Val Pro Leu Gly Ser Ala Met Ser Ala Asp Leu Ile Arg Arg Ala 165 170 175 Ser Thr Pro Ala Leu Trp Cys Ala Leu Thr Arg Leu Pro Asp Tyr Asp 180 185 190 Glu Lys Glu Gly Leu Pro Glu Asp Ser His Arg Glu Ile Arg Val His 195 200 205 Asp Thr Arg Tyr Ser Ala Asp Asp Glu Met Gly Phe Phe Ala Ser Gin 210 215 220 Ala Ala Gin Ile Ala Val Gin Glu Gly Ser Ala Asp Ile Gly Ser Ala 225 230 235 240 Ile His His Ala Arg Val Tyr Arg Cys Trp Lys Thr Asn Ala Lys Gly 245 250 255 Page 1615 of 3790 340 Arg Val Phe Gin Thr Asp Leu 270 Thr Val Pro Leu Pro Pro Gin 285 Arg Val Val Gin Ala Leu Gin 300 Leu Val Val Gly Asp Glu Ile 315 320 Asp Gly Gin Ile Gly Glu Tyr 330 335 Gly Asn Leu Ala Trp Lys His 350 Trp Val 845 1124 PRT Bifidobacterium longum Trp Pro Thr Ser Ser Ser Pro 10 15 Pro Leu Pro Gin Arg Asn Thr 30 Ile Thr Arg Glu Arg Cys Phe 45 Ile Asp Val Gly Leu Asn Ser 60 Asp Glu Asn Ser Pro Val Arg 75 80 Asp Gly Gly Val Asp Pro Gin 90 95 Asn Met Ser Gly Val Ala Arg 110 Page 1616 of 3790 Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu His Lys Leu 115 120 125 Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu Pro Glu Ser 130 135 140 Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu Leu Ala Thr 145 150 155 160 Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile Ser Ile Ala 165 170 175 Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Arg Gin 180 185 190 Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gin Tyr Gly Glu 195 200 205 Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr Ala Ala Glu 210 215 220 Glu Glu Ser Thr Pro Ala Gin Leu Val Val Ala Met Leu Asp Ala Gly 225 230 235 240 Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser Lys Lys Pro 245 250 255 Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gin Glu Asp Asn Ala 260 265 270 Asn Glu Leu Lys Gin Ile Phe Arg Val Gin Arg Val Pro Ala Asp Glu 275 280 285 Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser Pro Lys Gly 290 295 300 Ser Ala Glu Gin Arg Val Gly Gin Asp Pro Leu Ala Pro Glu Gin Ala 305 310 315 320 Arg Ala Leu Lys Ala Ser Leu Ala Phe Gin Glu Tyr Arg Ile Ala Asn 325 330 335 Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu Leu Arg Lys 340 345 350 Leu Thr Val Asp Glu Lys Gin Ser Ile Tyr Asp Gin Leu Val Ser Pro 355 360 365 Page 1617 of 3790 Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe Leu Gly Phe 370 375 380 Lys Arg Ser Gin Leu Lys Gly Val Gly Ser Leu Thr Glu Asp Gly Glu 385 390 395 400 Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val Gin Arg Ile 405 410 415 Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala Trp Trp Lys 420 425 430 Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu Leu Ser Asn 435 440 445 Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr Ala Ser Ala 450 455 460 Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr Lys Leu Asp 465 470 475 480 Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val Glu Thr Leu 485 490 495 Gin Lys Leu Thr Arg Gin Met Leu Thr Thr Asp Asp Asp Leu His Glu 500 505 510 Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg Pro Pro Ala 515 520 525 Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp Arg Val Leu 530 535 540 Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gin Gin Arg Trp Gly Asn 545 550 555 560 Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe Ser Ser Val 565 570 575 Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn Asn Glu Lys 580 585 590 Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gin Leu Arg Ala Asp Glu 595 600 605 Gin Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu Glu Ala Ile Page 1619 of 3790 Asn Ser Ser Arg Ser Leu Val Glu Gly Thr Leu His Gly Asn Ile 1100 1105 1110 Page 1620 of 3790 Gly Leu Leu Met Asp Ser Leu Thr Arg Arg Ser 1115 1120 846 166 PRT Bifidobacterium longum 846 Met Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser Pro Val Arg 15 10 15 Leu Leu Asn Ala Gin Ser Val Ile His Asp Gly Gly Val Asp Pro Gin 20 25 30 Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly Val Ala Arg 35 40 45 Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu His Lys Leu 50 55 60 Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu Pro Glu Ser 65 70 75 80 Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu Leu Ala Thr 85 90 95 Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile Ser Ile Ala 100 105 110 Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Arg Gin 115 120 125 Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gin Tyr Gly Glu 130 135 140 Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr Ala Ala Glu 145 150 155 160 Glu Glu Ser Thr Pro Ala 165 847 1138 PRT Bifidobacterium longum 847 Page 1621 of 3790 Met Asn Ser Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser 15 10 15 Pro Val Arg Leu Leu Asn Ala Gin Ser Val Ile His Asp Gly Gly Val 20 25 30 Asp Pro Gin Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly 35 40 45 Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu 50 55 60 His Lys Leu Asp Met Leu Leu Gly Lys Phe Gly Tyr Pro Val Ile Glu 65 70 75 80 Pro Glu Ser Leu Asp Lys Pro Phe Glu Glu Trp His Val Arg Ala Glu 85 90 95 Leu Ala Thr Arg Tyr Ile Glu Asp Asp Glu Leu Arg Arg Glu Ser Ile 100 105 110 Ser Ile Ala Leu Arg His Met Ala Arg His Arg Gly Trp Arg Asn Pro 115 120 125 Tyr Arg Gin Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gin 130 135 140 Tyr Gly Glu Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr 145 150 155 160 Ala Ala Glu Glu Glu Ser Thr Pro Ala Gin Leu Val Val Ala Met Leu 165 170 175 Asp Ala Gly Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser 180 185 190 Lys Lys Pro Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gin Glu 195 200 205 Asp Asn Ala Asn Glu Leu Lys Gin Ile Phe Arg Val Gin Arg Val Pro 210 215 220 Ala Asp Glu Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser 225 230 235 240 Pro Lys Gly Ser Ala Glu Gin Arg Val Gly Gin Asp Pro Leu Ala Pro 245 250 255 Page 1622 of 3790 Glu Gin Ala Arg Ala Leu Lys Ala Ser Leu Ala Phe Gin Glu Tyr Arg 260 265 270 Ile Ala Asn Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu 275 280 285 Leu Arg Lys Leu Thr Val Asp Glu Lys Gin Ser Ile Tyr Asp Gin Leu 290 295 300 Val Ser Pro Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe 305 310 315 320 Leu Gly Phe Lys Arg Ser Gin Leu Lys Gly Val Gly Ser Leu Thr Glu 325 330 335 Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val 340 345 350 Gin Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala 355 360 365 Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu 370 375 380 Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr 385 390 395 400 Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr 405 410 415 Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val 420 425 430 Glu Thr Leu Gin Lys Leu Thr Arg Gin Met Leu Thr Thr Asp Asp Asp 435 440 445 Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg 450 455 460 Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp 465 470 475 480 Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gin Gin Arg 485 490 495 Trp Gly Asn Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe 500 505 510 Page 1623 of 3790 Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn 515 520 525 Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gin Leu Arg 530 535 540 Ala Asp Glu Gin Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu 545 550 555 560 Glu Ala Ile Gin Arg Gin Asn Gly Gin Cys Leu Tyr Cys Gly Arg Thr 565 570 575 Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly 580 585 590 Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala Glu 595 600 605 Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg Ser 610 615 620 Glu Asp Ala Gin Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys Arg 625 630 635 640 Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu Val 645 650 655 Lys Ala Phe Lys Gin Ala Val Ile Ala Arg Leu Gin Gin Thr Glu Asp 660 665 670 Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala 675 680 685 Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gin Tyr 690 695 700 Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys Thr 705 710 715 720 Thr Val Ser Val Phe Gin Gly Arg Val Thr Ala Ser Ala Arg Arg Ala 725 730 735 Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly Gin Gin Ser Lys Thr 740 745 750 Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala Met Page 1624 of 3790 Page 1625 of 3790 848 182 PRT Bifidobacterium longum 848 Met Arg Gly Lys Arg Tyr Arg Ile Gly Ile Asp Val Gly Leu Asn Ser 15 10 15 Val Gly Leu Ala Ala Val Glu Val Ser Asp Glu Asn Ser Pro Val Arg 20 25 30 Leu Leu Asn Ala Gin Ser Val Ile His Asp Gly Gly Val Asp Pro Gin 35 40 45 Lys Asn Lys Glu Ala Ile Thr Arg Lys Asn Met Ser Gly Val Ala Arg 50 55 60 Arg Thr Arg Arg Met Arg Arg Arg Lys Arg Glu Arg Leu His Lys Leu 65 70 75 80 Page 1626 of 3790 Page 1627 of 3790 Asp Ala Ser Ala Glu Leu Arg Lys Leu Thr Val Asp Glu Lys Gin Ser 115 120 125 Ile Tyr Asp Gin Leu Val Ser Pro Ser Ser Glu Asp Ile Thr Trp Ser 130 135 140 Asp Leu Cys Asp Phe Leu Gly Phe Lys Arg Ser Gin Leu Lys Gly Val 145 150 155 160 Gly Ser Leu Thr Glu Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro 165 170 175 Arg Leu Thr Ser Val Gin Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg 180 185 190 Lys Pro Leu Val Ala Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu 195 200 205 Ala Met Ile Arg Leu Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg 210 215 220 Glu Asp Val Ala Tyr Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp 225 230 235 240 Asp Asp Ala Leu Thr Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg 245 250 255 Ala Ala Tyr Ser Val Glu Thr Leu Gin Lys Leu Thr Arg Gin Met Leu 260 265 270 Thr Thr Asp Asp Asp Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val 275 280 285 Thr Asp Ser Trp Arg Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly 290 295 300 Asn Pro Ser Val Asp Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met 305 310 315 320 Asn Cys Gin Gin Arg Trp Gly Asn Pro Val Ser Val Asn Ile Glu His 325 330 335 Val Arg Ser Ser Phe Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg 340 345 350 Glu Tyr Glu Lys Asn Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu 355 360 365 Page 1628 of 3790 Page 1629 of 3790 Asp Leu Cys Asp Phe Leu Gly Phe Lys Arg Ser Gin Leu Lys Gly Val 145 150 155 160 Gly Ser Leu Thr Glu Asp Gly Glu Glu Arg Ile Ser Ser Arg Pro Pro 165 170 175 Arg Leu Thr Ser Val Gin Arg Ile Tyr Glu Ser Asp Asn Lys Ile Arg 180 185 190 Lys Pro Leu Val Ala Trp Trp Lys Ser Ala Ser Asp Asn Glu His Glu 195 200 205 Ala Met Ile Arg Leu Leu Ser Asn Thr Val Asp Ile Asp Lys Val Arg 210 215 220 Glu Asp Val Ala Tyr Ala Ser Ala Ile Glu Phe Ile Asp Gly Leu Asp 225 230 235 240 Asp Asp Ala Leu Thr Lys Leu Asp Ser Val Asp Leu Pro Ser Gly Arg 245 250 255 Ala Ala Tyr Ser Val Glu Thr Leu Gin Lys Leu Thr Arg Gin Met Leu 260 265 270 Thr Thr Asp Asp Asp Leu His Glu Ala Arg Lys Thr Leu Phe Asn Val 275 280 285 Thr Asp Ser Trp Arg Pro Pro Ala Asp Pro Ile Gly Glu Pro Leu Gly 290 295 300 Asn Pro Ser Val Asp Arg Val Leu Lys Asn Val Asn Arg Tyr Leu Met 305 310 315 320 Asn Cys Gin Gin Arg Trp Gly Asn Pro Val Ser Val Asn Ile Glu His 325 330 335 Val Arg Ser Ser Phe Ser Ser Val Ala Phe Ala Arg Lys Asp Lys Arg 340 345 350 Glu Tyr Glu Lys Asn Asn Glu Lys Arg Ser Ile Phe Arg Ser Ser Leu 355 360 365 Ser Glu Gin Leu Arg Ala Asp Glu Gin Met Glu Lys Val Arg Glu Ser 370 375 380 Asp Leu Arg Arg Leu Glu Ala Ile Gin Arg Gin Asn Gly Gin Cys Leu 385 390 395 400 Page 1630 of 3790 Tyr Cys Gly Arg Thr Ile Thr Phe Arg Thr Cys Glu Met Asp His Ile 405 410 415 Val Pro Arg Lys Gly Val Gly Ser Thr Asn Thr Arg Thr Asn Phe Ala 420 425 430 Ala Val Cys Ala Glu Cys Asn Arg Met Lys Ser Asn Thr Pro Phe Ala 435 440 445 Ile Trp Ala Arg Ser Glu Asp Ala Gin Thr Arg Gly Val Ser Leu Ala 450 455 460 Glu Ala Lys Lys Arg Val Thr Met Phe Thr Phe Asn Pro Lys Ser Tyr 465 470 475 480 Ala Pro Arg Glu Val Lys Ala Phe Lys Gin Ala Val Ile Ala Arg Leu 485 490 495 Gin Gin Thr Glu Asp Asp Ala Ala Ile Asp Asn Arg Ser Ile Glu Ser 500 505 510 Val Ala Trp Met Ala Asp Glu Leu His Arg Arg Ile Asp Trp Tyr Phe 515 520 525 Asn Ala Lys Gin Tyr Val Asn Ser Ala Ser Ile Asp Asp Ala Glu Ala 530 535 540 Glu Thr Met Lys Thr Thr Val Ser Val Phe Gin Gly Arg Val Thr Ala 545 550 555 560 Ser Ala Arg Arg Ala Ala Gly Ile Glu Gly Lys Ile His Phe Ile Gly 565 570 575 Gin Gin Ser Lys Thr Arg Leu Asp Arg Arg His His Ala Val Asp Ala 580 585 590 Ser Val Ile Ala Met Met Asn Thr Ala Ala Ala Gin Thr Leu Met Glu 595 600 605 Arg Glu Ser Leu Arg Glu Ser Gin Arg Leu Ile Gly Leu Met Pro Gly 610 615 620 Glu Arg Ser Trp Lys Glu Tyr Pro Tyr Glu Gly Thr Ser Arg Tyr Glu 625 630 635 640 Ser Phe His Leu Trp Leu Asp Asn Met Asp Val Leu Leu Glu Leu Leu Page 1632 of 3790 965 851 1151 PRT Bifidobacterium sp. Page 1633 of 3790 Val Asp Ser Leu Ile Ser Asp Asn Pro Tyr Ser Lys Gin Tyr Gly Glu 145 150 155 160 Leu Lys Glu Lys Ala Lys Ala Tyr Asn Asp Asp Ala Thr Ala Ala Glu 165 170 175 Glu Glu Ser Thr Pro Ala Gin Leu Val Val Ala Met Leu Asp Ala Gly 180 185 190 Tyr Ala Glu Ala Pro Arg Leu Arg Trp Arg Thr Gly Ser Lys Lys Pro 195 200 205 Asp Ala Glu Gly Tyr Leu Pro Val Arg Leu Met Gin Glu Asp Asn Ala 210 215 220 Asn Glu Leu Lys Gin Ile Phe Arg Val Gin Arg Val Pro Ala Asp Glu 225 230 235 240 Trp Lys Pro Leu Phe Arg Ser Val Phe Tyr Ala Val Ser Pro Lys Gly 245 250 255 Ser Ala Glu Gin Arg Val Gly Gin Asp Pro Leu Ala Pro Glu Gin Ala 260 265 270 Arg Ala Leu Lys Ala Ser Leu Ala Phe Gin Glu Tyr Arg Ile Ala Asn 275 280 285 Val Ile Thr Asn Leu Arg Ile Lys Asp Ala Ser Ala Glu Leu Arg Lys 290 295 300 Leu Thr Val Asp Glu Lys Gin Ser Ile Tyr Asp Gin Leu Val Ser Pro 305 310 315 320 Ser Ser Glu Asp Ile Thr Trp Ser Asp Leu Cys Asp Phe Leu Gly Phe 325 330 335 Lys Arg Ser Gin Leu Lys Gly Val Gly Ser Leu Thr Glu Asp Gly Glu 340 345 350 Glu Arg Ile Ser Ser Arg Pro Pro Arg Leu Thr Ser Val Gin Arg Ile 355 360 365 Tyr Glu Ser Asp Asn Lys Ile Arg Lys Pro Leu Val Ala Trp Trp Lys 370 375 380 Ser Ala Ser Asp Asn Glu His Glu Ala Met Ile Arg Leu Leu Ser Asn 385 390 395 400 Page 1634 of 3790 Thr Val Asp Ile Asp Lys Val Arg Glu Asp Val Ala Tyr Ala Ser Ala 405 410 415 Ile Glu Phe Ile Asp Gly Leu Asp Asp Asp Ala Leu Thr Lys Leu Asp 420 425 430 Ser Val Asp Leu Pro Ser Gly Arg Ala Ala Tyr Ser Val Glu Thr Leu 435 440 445 Gin Lys Leu Thr Arg Gin Met Leu Thr Thr Asp Asp Asp Leu His Glu 450 455 460 Ala Arg Lys Thr Leu Phe Asn Val Thr Asp Ser Trp Arg Pro Pro Ala 465 470 475 480 Asp Pro Ile Gly Glu Pro Leu Gly Asn Pro Ser Val Asp Arg Val Leu 485 490 495 Lys Asn Val Asn Arg Tyr Leu Met Asn Cys Gin Gin Arg Trp Gly Asn 500 505 510 Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe Ser Ser Val 515 520 525 Ala Phe Ala Arg Lys Asp Lys Arg Glu Tyr Glu Lys Asn Asn Glu Lys 530 535 540 Arg Ser Ile Phe Arg Ser Ser Leu Ser Glu Gin Leu Arg Ala Asp Glu 545 550 555 560 Gin Met Glu Lys Val Arg Glu Ser Asp Leu Arg Arg Leu Glu Ala Ile 565 570 575 Gin Arg Gin Asn Gly Gin Cys Leu Tyr Cys Gly Arg Thr Ile Thr Phe 580 585 590 Arg Thr Cys Glu Met Asp His Ile Val Pro Arg Lys Gly Val Gly Ser 595 600 605 Thr Asn Thr Arg Thr Asn Phe Ala Ala Val Cys Ala Glu Cys Asn Arg 610 615 620 Met Lys Ser Asn Thr Pro Phe Ala Ile Trp Ala Arg Ser Glu Asp Ala 625 630 635 640 Gin Thr Arg Gly Val Ser Leu Ala Glu Ala Lys Lys Arg Val Thr Met 645 650 655 Page 1635 of 3790 Phe Thr Phe Asn Pro Lys Ser Tyr Ala Pro Arg Glu Val Lys Ala Phe 660 665 670 Lys Gin Ala Val Ile Ala Arg Leu Gin Gin Thr Glu Asp Asp Ala Ala 675 680 685 Ile Asp Asn Arg Ser Ile Glu Ser Val Ala Trp Met Ala Asp Glu Leu 690 695 700 His Arg Arg Ile Asp Trp Tyr Phe Asn Ala Lys Gin Tyr Val Asn Ser 705 710 715 720 Ala Ser Ile Asp Asp Ala Glu Ala Glu Thr Met Lys Thr Thr Val Ser 725 730 735 Val Phe Gin Gly Arg Val Thr Ala Ser Ala Arg Arg Ala Ala Gly Ile 740 745 750 Glu Gly Lys Ile His Phe Ile Gly Gin Gin Ser Lys Thr Arg Leu Asp 755 760 765 Arg Arg His His Ala Val Asp Ala Ser Val Ile Ala Met Met Asn Thr 770 775 780 Ala Ala Ala Gin Thr Leu Met Glu Arg Glu Ser Leu Arg Glu Ser Gin 785 790 795 800 Arg Leu Ile Gly Leu Met Pro Gly Glu Arg Ser Trp Lys Glu Tyr Pro 805 810 815 Tyr Glu Gly Thr Ser Arg Tyr Glu Ser Phe His Leu Trp Leu Asp Asn 820 825 830 Met Asp Val Leu Leu Glu Leu Leu Asn Asp Ala Leu Asp Asn Asp Arg 835 840 845 Ile Ala Val Met Gin Ser Gin Arg Tyr Val Leu Gly Asn Ser Ile Ala 850 855 860 His Asp Ala Thr Ile His Pro Leu Glu Lys Val Pro Leu Gly Ser Ala 865 870 875 880 Met Ser Ala Asp Leu Ile Arg Arg Ala Ser Thr Pro Ala Leu Trp Cys 885 890 895 Ala Leu Thr Arg Leu Pro Asp Tyr Asp Glu Lys Glu Gly Leu Pro Glu 900 910 Page 1636 of 3790 905 Page 1637 of 3790 Cys Ser Trp Gin Trp Arg His Glu 1145 1150 852 1092 PRT Brevibacillus laterosporus 852 Met Ala Tyr Thr Met Gly Ile Asp 1 5 Val Gly Ile Ala Ser Cys Gly Trp 10 15 Ala Ile Val Asp Leu Glu Arg Gin 20 Arg Ile Ile Asp Ile Gly Val Arg 25 30 Thr Phe Glu Lys Ala Glu Asn Pro 35 40 Lys Asn Gly Glu Ala Leu Ala Val 45 Pro Arg Arg Glu Ala Arg Ser Ser 50 55 Arg Arg Arg Leu Arg Arg Lys Lys 60 His Arg Ile Glu Arg Leu Lys Tyr 65 70 Met Phe Val Arg Asn Gly Leu Ala 75 80 Val Asp Ile Gin His Leu Glu Gin 85 Thr Leu Arg Ser Gin Asn Glu Ile 90 95 Asp Val Trp Gin Leu Arg Val Asp 100 Gly Leu Asp Arg Met Leu Thr Gin 105 110 Lys Glu Trp Leu Arg Val Leu Ile 115 120 His Leu Ala Gin Arg Arg Gly Phe 125 Gin Ser Asn Arg Lys Thr Asp Gly 130 135 Ser Ser Glu Asp Gly Gin Val Leu 140 Val Asn Val Thr Glu Asn Asp Arg 145 150 Leu Met Glu Glu Lys Asp Tyr Arg 155 160 Thr Val Ala Glu Met Met Val Lys 165 Asp Glu Lys Phe Ser Asp His Lys 170 175 Arg Asn Lys Asn Gly Asn Tyr His 180 Gly Val Val Ser Arg Ala Ser Leu 185 190 Leu Val Glu Ile His Thr Leu Phe 195 200 Glu Ser Gin Arg Gin His His Asn 205 Page 1638 of 3790 Phe Leu Ala Ser Lys Asp Phe Glu Leu Glu Tyr Ile Asn Ile Trp Ser 210 215 220 Ser Gin Arg Pro Val Ala Thr Lys Asp Gin Ile Glu Lys Met Ile Gly 225 230 235 240 Thr Cys Thr Phe Leu Pro Lys Glu Lys Arg Ala Pro Lys Ala Ser Trp 245 250 255 His Phe Gin Tyr Phe Met Leu Leu Gin Thr Ile Asn His Ile Arg Ile 260 265 270 Thr Asn Ala Gin Gly Thr Arg Pro Leu Asn Lys Glu Glu Ile Glu Gin 275 280 285 Val Val Asn Met Ala Leu Thr Lys Ser Lys Val Ser Tyr His Asp Ile 290 295 300 Arg Lys Val Leu Asp Leu Ser Glu Glu Tyr Gin Phe Val Gly Leu Asp 305 310 315 320 Tyr Gly Lys Glu Asp Glu Lys Lys Lys Val Glu Ser Lys Glu Thr Ile 325 330 335 Ile Lys Leu Asp Asp Tyr His Lys Leu Asn Lys Ile Phe Asn Glu Val 340 345 350 Glu Leu Ala Lys Gly Glu Thr Trp Glu Ala Val Asp Tyr Asp Thr Val 355 360 365 Ala Tyr Ala Leu Thr Phe Phe Lys Asp Asp Glu Asp Ile Arg Asp Tyr 370 375 380 Leu Gin Asn Lys Tyr Lys Asp Ser Lys Asn Arg Leu Val Lys Asn Val 385 390 395 400 Ala Asn Lys Glu Tyr Thr Asn Glu Leu Ile Glu Lys Val Ser Thr Leu 405 410 415 Ser Phe Arg Lys Val Gly His Leu Ser Leu Lys Ala Leu Arg Lys Ile 420 425 430 Ile Pro Phe Leu Glu Gin Gly Met Thr Tyr Asp Lys Ala Cys Gin Ala 435 440 445 Ala Gly Phe Asn Phe Gin Gly Ile Ser Lys Lys Lys Arg Ser Val Val 450 455 460 Page 1639 of 3790 Leu Pro Val Ile Asp Gin Ile Ser Asn Pro Val Val Asn Arg Ala Leu 465 470 475 480 Thr Gin Thr Arg Lys Val Ile Asn Ala Leu Ile Lys Lys Tyr Gly Ser 485 490 495 Pro Glu Thr Ile His Ile Glu Thr Ala Arg Glu Leu Ser Lys Arg Phe 500 505 510 Asp Glu Arg Lys Asn Ile Thr Lys Asp Tyr Lys Glu Asn Arg Asp Lys 515 520 525 Asn Glu Arg Ala Lys Lys His Leu Ser Glu Leu Gly Ile Ile Asn Pro 530 535 540 Thr Gly Leu Asp Ile Val Lys Tyr Lys Leu Trp Cys Glu Gin Gin Gly 545 550 555 560 Arg Cys Met Tyr Ser Asn Gin Pro Ile Ser Phe Glu Arg Leu Arg Glu 565 570 575 Ser Gly Tyr Thr Glu Val Asp His Ile Ile Pro Tyr Ser Arg Ser Met 580 585 590 Asn Asp Ser Tyr Asn Asn Arg Val Leu Val Met Thr Arg Glu Asn Arg 595 600 605 Glu Lys Ser Asn Gin Thr Pro Tyr Glu Tyr Met Gly Asn Asp Thr Gin 610 615 620 Arg Trp Asp Glu Phe Glu Gin Arg Val Thr Thr Asn Pro Gin Ile Lys 625 630 635 640 Lys Glu Lys Arg Gin Asn Leu Leu Leu Lys Gly Phe Thr Asn Arg Arg 645 650 655 Glu Leu Glu Met Leu Glu Arg Asn Leu Asn Asp Thr Arg His Ile Thr 660 665 670 Lys Tyr Leu Ser His Phe Ile Ser Thr Asn Leu Glu Phe Ser Pro Ser 675 680 685 Asp Lys Lys Lys Lys Val Val Asn Thr Ser Gly Arg Ile Thr Ser His 690 695 700 Leu Arg Ser Arg Trp Gly Leu Glu Lys Asn Arg Glu Gin Asn Asp Leu 705 710 715 720 Page 1640 of 3790 His His Ala Met Asp Ala Val Val Ile Ala Val Thr Ser Asp Ser Phe 725 730 735 Ile Gin Gin Val Thr Asn Tyr Tyr Lys Arg Lys Glu Arg Arg Glu Leu 740 745 750 Asn Gly Asp Asp Lys Phe Pro Leu Pro Trp Lys Phe Phe Arg Glu Glu 755 760 765 Val Ile Ala Arg Leu Ser Pro Asn Pro Lys Glu Gin Ile Glu Ala Leu 770 775 780 Pro Asn His Phe Tyr Ser Glu Asp Glu Leu Ala Asp Leu Gin Pro Ile 785 790 795 800 Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Glu Ala His Gin 805 810 815 Ala Gin Phe Arg Arg Val Val Gly Lys Thr Lys Glu Gly Lys Asn Ile 820 825 830 Thr Ala Lys Lys Thr Ala Leu Val Asp Ile Ser Tyr Asp Lys Asn Gly 835 840 845 Asp Phe Asn Met Tyr Gly Arg Glu Thr Asp Pro Ala Thr Tyr Glu Ala 850 855 860 Ile Lys Glu Arg Tyr Leu Glu Phe Gly Gly Asn Ala Lys Lys Ala Phe 865 870 875 880 Ser Thr Asp Leu His Lys Pro Lys Lys Asp Gly Thr Lys Gly Pro Leu 885 890 895 Ile Lys Ser Val Arg Ile Met Glu Asn Lys Thr Leu Val His Pro Val 900 905 910 Asn Lys Gly Lys Gly Val Val Tyr Asn Ser Ser Ile Val Arg Thr Asp 915 920 925 Val Phe Gin Arg Lys Glu Lys Tyr Tyr Leu Leu Pro Val Tyr Val Thr 930 935 940 Asp Val Thr Lys Gly Lys Leu Pro Asn Lys Val Ile Ala Ala Lys Lys 945 950 955 960 Gly Tyr Asp Asp Trp Ile Glu Val Asp Asp Ser Phe Thr Phe Leu Tyr 965 975 Page 1641 of 3790 970 Ser Leu Tyr Pro Asn Asp Leu Ile Phe Ile Arg Gin Asn Pro Lys Lys 980 985 990 Lys Ile Ser Leu Lys Lys Arg Ile Glu Ser His Ser Ile Ser Asp Ser 995 1000 1005 Glu Phe Lys Leu Ser Phe Tyr Lys Glu Asp Ile Ile Glu Tyr Glu Lys 20 25 30 Asn Gly Asp Ile Leu Val Glu Arg Phe Leu Ser Arg Thr Met Pro Gin 35 40 45 Val Arg Asn Tyr Ile Glu Thr Lys Pro Ile Asp Arg Pro Lys Tyr Asp 50 55 60 Lys Arg Asn Pro Val Gly Leu Ser Lys Thr Ser Ser Ile Arg Lys Ile 65 70 75 80 Thr Met Asp Ile Leu Gly Asn Arg Phe Tyr Val Asp Lys Met Ser Phe Asn 855 Page 1643 of 3790 1442 PRT Caenispirillum salinarum 855 Met Pro Val Leu Ser Pro Leu Ser Pro Asn Ala Ala Gin Gly Arg Arg 15 10 15 Arg Trp Ser Leu Ala Leu Asp Ile Gly Glu Gly Ser Ile Gly Trp Ala 20 25 30 Val Ala Glu Val Asp Ala Glu Gly Arg Val Leu Gin Leu Thr Gly Thr 35 40 45 Gly Val Thr Leu Phe Pro Ser Ala Trp Ser Asn Glu Asn Gly Thr Tyr 50 55 60 Val Ala His Gly Ala Ala Asp Arg Ala Val Arg Gly Gin Gin Gin Arg 65 70 75 80 His Asp Ser Arg Arg Arg Arg Leu Ala Gly Leu Ala Arg Leu Cys Ala 85 90 95 Pro Val Leu Glu Arg Ser Pro Glu Asp Leu Lys Asp Leu Thr Arg Thr 100 105 110 Pro Pro Lys Ala Asp Pro Arg Ala Ile Phe Phe Leu Arg Ala Asp Ala 115 120 125 Ala Arg Arg Pro Leu Asp Gly Pro Glu Leu Phe Arg Val Leu His His 130 135 140 Met Ala Ala His Arg Gly Ile Arg Leu Ala Glu Leu Gin Glu Val Asp 145 150 155 160 Pro Pro Pro Glu Ser Asp Ala Asp Asp Ala Ala Pro Ala Ala Thr Glu 165 170 175 Asp Glu Asp Gly Thr Arg Arg Ala Ala Ala Asp Glu Arg Ala Phe Arg 180 185 190 Arg Leu Met Ala Glu His Met His Arg His Gly Thr Gin Pro Thr Cys 195 200 205 Gly Glu Ile Met Ala Gly Arg Leu Arg Glu Thr Pro Ala Gly Ala Gin 210 215 220 Pro Val Thr Arg Ala Arg Asp Gly Leu Arg Val Gly Gly Gly Val Ala Page 1645 of 3790 Ala Thr Ala Ala Ile Leu Glu Ser Asp Ile Met Gin Pro Gly Arg Tyr 485 490 495 Ser Val Cys Pro Trp Ala Ala Glu Ala Ile Leu Asp Ala Trp Ala Asn 500 505 510 Ala Pro Thr Glu Gly Phe Tyr Asp Val Thr Arg Gly Leu Phe Gly Phe 515 520 525 Ala Pro Gly Glu Ile Val Leu Glu Asp Leu Arg Arg Ala Arg Gly Ala 530 535 540 Leu Leu Ala His Leu Pro Arg Thr Met Ala Ala Ala Arg Thr Pro Asn 545 550 555 560 Arg Ala Ala Gin Gin Arg Gly Pro Leu Pro Ala Tyr Glu Ser Val Ile 565 570 575 Pro Ser Gin Leu Ile Thr Ser Leu Arg Arg Ala His Lys Gly Arg Ala 580 585 590 Ala Asp Trp Ser Ala Ala Asp Pro Glu Glu Arg Asn Pro Phe Leu Arg 595 600 605 Thr Trp Thr Gly Asn Ala Ala Thr Asp His Ile Leu Asn Gin Val Arg 610 615 620 Lys Thr Ala Asn Glu Val Ile Thr Lys Tyr Gly Asn Arg Arg Gly Trp 625 630 635 640 Asp Pro Leu Pro Ser Arg Ile Thr Val Glu Leu Ala Arg Glu Ala Lys 645 650 655 His Gly Val Ile Arg Arg Asn Glu Ile Ala Lys Glu Asn Arg Glu Asn 660 665 670 Glu Gly Arg Arg Lys Lys Glu Ser Ala Ala Leu Asp Thr Phe Cys Gin 675 680 685 Asp Asn Thr Val Ser Trp Gin Ala Gly Gly Leu Pro Lys Glu Arg Ala 690 695 700 Ala Leu Arg Leu Arg Leu Ala Gin Arg Gin Glu Phe Phe Cys Pro Tyr 705 710 715 720 Cys Ala Glu Arg Pro Lys Leu Arg Ala Thr Asp Leu Phe Ser Pro Ala 725 730 735 Page 1646 of 3790 Glu Thr Glu Ile Asp His Val Ile Glu Arg Arg Met Gly Gly Asp Gly 740 745 750 Pro Asp Asn Leu Val Leu Ala His Lys Asp Cys Asn Asn Ala Lys Gly 755 760 765 Lys Lys Thr Pro His Glu His Ala Gly Asp Leu Leu Asp Ser Pro Ala 770 775 780 Leu Ala Ala Leu Trp Gin Gly Trp Arg Lys Glu Asn Ala Asp Arg Leu 785 790 795 800 Lys Gly Lys Gly His Lys Ala Arg Thr Pro Arg Glu Asp Lys Asp Phe 805 810 815 Met Asp Arg Val Gly Trp Arg Phe Glu Glu Asp Ala Arg Ala Lys Ala 820 825 830 Glu Glu Asn Gin Glu Arg Arg Gly Arg Arg Met Leu His Asp Thr Ala 835 840 845 Arg Ala Thr Arg Leu Ala Arg Leu Tyr Leu Ala Ala Ala Val Met Pro 850 855 860 Glu Asp Pro Ala Glu Ile Gly Ala Pro Pro Val Glu Thr Pro Pro Ser 865 870 875 880 Pro Glu Asp Pro Thr Gly Tyr Thr Ala Ile Tyr Arg Thr Ile Ser Arg 885 890 895 Val Gin Pro Val Asn Gly Ser Val Thr His Met Leu Arg Gin Arg Leu 900 905 910 Leu Gin Arg Asp Lys Asn Arg Asp Tyr Gin Thr His His Ala Glu Asp 915 920 925 Ala Cys Leu Leu Leu Leu Ala Gly Pro Ala Val Val Gin Ala Phe Asn 930 935 940 Thr Glu Ala Ala Gin His Gly Ala Asp Ala Pro Asp Asp Arg Pro Val 945 950 955 960 Asp Leu Met Pro Thr Ser Asp Ala Tyr His Gin Gin Arg Arg Ala Arg 965 970 975 Ala Leu Gly Arg Val Pro Leu Ala Thr Val Asp Ala Ala Leu Ala Asp 980 985 990 Page 1647 of 3790 Ile Val Met Pro Glu Ser Asp Arg Gin Asp Pro Glu Thr Gly Arg Val 995 1000 1005 Met Arg Glu Ala Arg Ala Pro Ser Leu Val Arg Ile Arg Ala Asn 856 984 PRT Campylobacter coli Page 1649 of 3790 856 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Cys Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 Page 1650 of 3790 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Page 1651 of 3790 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Page 1652 of 3790 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970 975 Arg Gin Arg Glu Asp Phe Lys Lys 980 857 Page 1653 of 3790 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Thr Gin Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser Page 1655 of 3790 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Page 1656 of 3790 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970 975 Arg Gin Arg Glu Asp Phe Lys Lys 980 Page 1657 of 3790 858 984 PRT Campylobacter coli 858 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe 180 Ile Asn Val Arg Asn 185 Lys Lys Glu Ser Tyr Glu 190 Arg Cys Ile Ala Gin 195 Ser Phe Leu Lys Asp Glu Leu 200 Lys 205 Leu Ile Phe Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Page 1658 of 3790 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asn Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Page 1660 of 3790 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970 975 Page 1661 of 3790 Arg Gin Arg Glu Asp Phe Lys Lys 980 859 984 PRT Campylobacter coli 859 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe 180 Ile Asn Val Arg Asn 185 Lys Lys Glu Ser Tyr Glu 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Page 1662 of 3790 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Page 1663 of 3790 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser Page 1665 of 3790 Page 1666 of 3790 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asn Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Page 1667 of 3790 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Page 1668 of 3790 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 405 410 415 Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Page 1671 of 3790 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asn Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Page 1672 of 3790 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Page 1673 of 3790 Page 1674 of 3790 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Page 1676 of 3790 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Page 1677 of 3790 Page 1678 of 3790 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Page 1679 of 3790 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Page 1681 of 3790 Page 1682 of 3790 Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gin 145 150 155 160 Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 165 170 175 Ser Val Pro Arg Ser Leu Leu Lys Gin Glu Leu Asp Leu Ile Leu Asp 180 185 190 Lys Gin Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Ala Lys 195 200 205 Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 210 215 220 Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 225 230 235 240 Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 245 250 255 Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 260 265 270 Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 275 280 285 Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gin Asp Ile Asn Phe 290 295 300 Lys Gly Leu Asp Tyr Ser Lys Asn Asn Val Glu Asn Ser Lys Leu Val 305 310 315 320 Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 325 330 335 Thr Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 340 345 350 Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 355 360 365 Val Leu Asn Ala Glu Gin Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 370 375 380 Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gin Ile Ile Pro Leu 385 390 395 400 Page 1683 of 3790 Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 405 410 415 Thr Ile Ala Lys Asn Gin Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 420 425 430 Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 435 440 445 Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 450 455 460 Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 465 470 475 480 Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gin Asn Glu Gin 485 490 495 Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 500 505 510 Thr Ser Lys Asn Ile Gin Ile Val Arg Leu Phe Glu Asp Gin Lys Gly 515 520 525 Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 530 535 540 Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 545 550 555 560 Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gin 565 570 575 Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 580 585 590 Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 595 600 605 Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 610 615 620 Gin Thr Leu Gin Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 625 630 635 640 Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 645 650 655 Page 1684 of 3790 Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gin His Val Ile Leu Ser 660 665 670 Ser Gly Met Ile Thr Gin Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 675 680 685 Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 690 695 700 Ala Phe Thr Thr Asn Ser Ile Ile Phe Thr Phe Asn Asn Phe Lys Lys 705 710 715 720 Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 725 730 735 Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 740 745 750 Lys Glu Gin Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 755 760 765 Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 770 775 780 Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 785 790 795 800 Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Lys 805 810 815 Gly Ser Leu Val Arg Thr Asp Leu Phe Ala Asp Lys Glu Asn Lys Phe 820 825 830 His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 835 840 845 Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 850 855 860 Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 865 870 875 880 Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 885 890 895 Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gin Page 1687 of 3790 Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 405 410 415 Thr Ile Ala Lys Asn Gin Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 420 425 430 Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 435 440 445 Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 450 455 460 Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 465 470 475 480 Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gin Asn Glu Gin 485 490 495 Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 500 505 510 Thr Ser Lys Asn Ile Gin Ile Val Arg Leu Phe Glu Asp Gin Lys Gly 515 520 525 Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 530 535 540 Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 545 550 555 560 Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gin 565 570 575 Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 580 585 590 Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 595 600 605 Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 610 615 620 Gin Thr Leu Gin Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 625 630 635 640 Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 645 650 655 Page 1688 of 3790 Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gin His Val Val Leu Ser 660 665 670 Ser Gly Met Ile Thr Gin Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 675 680 685 Lys Asn His Lys Asn Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 690 695 700 Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 705 710 715 720 Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 725 730 735 Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 740 745 750 Lys Glu Gin Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 755 760 765 Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 770 775 780 Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 785 790 795 800 Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Thr Lys 805 810 815 Gly Ser Leu Val Arg Thr Asp Leu Phe Val Asp Lys Glu Asn Lys Phe 820 825 830 His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 835 840 845 Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 850 855 860 Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 865 870 875 880 Pro Val Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 885 890 895 Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 900 905 910 Page 1689 of 3790 Page 1690 of 3790 Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 165 170 175 Ser Val Pro Arg Ser Leu Leu Lys Gin Glu Leu Asp Leu Ile Leu Asp 180 185 190 Lys Gin Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Glu Lys 195 200 205 Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 210 215 220 Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 225 230 235 240 Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 245 250 255 Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 260 265 270 Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 275 280 285 Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gin Asp Ile Asn Phe 290 295 300 Lys Gly Leu Asp Tyr Ser Lys Asn Asn Ala Glu Asn Ser Lys Leu Val 305 310 315 320 Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 325 330 335 Ala Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 340 345 350 Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 355 360 365 Val Leu Asn Ala Glu Gin Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 370 375 380 Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gin Ile Ile Pro Leu 385 390 395 400 Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe Leu Asn Glu Tyr Leu Leu Phe Leu Pro Ile Asn Glu Asp Glu Asn Thr 645 650 655 Page 1692 of 3790 Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gin His Val Val Leu Ser 660 665 670 Ser Gly Met Ile Thr Gin Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 675 680 685 Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 690 695 700 Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 705 710 715 720 Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 725 730 735 Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 740 745 750 Lys Glu Gin Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 755 760 765 Leu Lys Ile Lys Asn Lys Gly Thr Leu His Glu Leu Thr Pro Leu Lys 770 775 780 Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 785 790 795 800 Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Lys 805 810 815 Gly Ser Leu Val Arg Thr Asp Leu Phe Ala Asp Lys Glu Asn Lys Phe 820 825 830 His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 835 840 845 Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 850 855 860 Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 865 870 875 880 Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 885 890 895 Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 900 905 910 Page 1693 of 3790 Page 1694 of 3790 Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 165 170 175 Ser Val Pro Arg Ser Leu Leu Lys Gin Glu Leu Asp Leu Ile Leu Asp 180 185 190 Arg Gin Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Ala Lys 195 200 205 Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 210 215 220 Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 225 230 235 240 Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 245 250 255 Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 260 265 270 Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 275 280 285 Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gin Asp Ile Asn Phe 290 295 300 Lys Gly Leu Asp Tyr Ser Lys Asn Asn Val Glu Asn Ser Lys Leu Val 305 310 315 320 Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 325 330 335 Thr Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 340 345 350 Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 355 360 365 Val Leu Asn Ala Glu Gin Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 370 375 380 Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gin Ile Ile Pro Leu 385 390 395 400 Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 405 410 415 Page 1695 of 3790 Thr Ile Ala Lys Asn Gin Glu Lys Asn Glu Tyr Leu Pro Leu Phe Glu 420 425 430 Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 435 440 445 Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 450 455 460 Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 465 470 475 480 Phe Asn Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gin Asn Glu Gin 485 490 495 Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 500 505 510 Thr Ser Lys Asn Ile Gin Ile Val Arg Leu Phe Glu Asp Gin Lys Gly 515 520 525 Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Lys Cys Leu Asp Glu 530 535 540 Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 545 550 555 560 Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Asn Asp Leu Lys Gin 565 570 575 Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 580 585 590 Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 595 600 605 Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 610 615 620 Gin Thr Leu Gin Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 625 630 635 640 Leu Asn Glu His Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 645 650 655 Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gin His Val Ile Leu Ser 885 890 895 Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 900 905 910 Page 1697 of 3790 Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 915 920 925 Lys Asn Asp Lys Glu 930 868 666 PRT Campylobacter jejuni 868 Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu 15 10 15 Phe Ile Lys Ala Leu Asp Glu His Ser Leu Ser Gin Asp Asp Leu Asn 20 25 30 Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu Lys 35 40 45 Lys Ala Leu Ala Lys Tyr Asp Leu Lys Glu Asn Gin Ile Asp Ser Leu 50 55 60 Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu 65 70 75 80 Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu Ala 85 90 95 Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys Asp 100 105 110 Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr Asn 115 120 125 Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn Ala 130 135 140 Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala 145 150 155 160 Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys Glu 165 170 175 Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu 180 185 190 Page 1698 of 3790 Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu 195 200 205 Phe Lys Glu Gin Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile Lys 210 215 220 Leu Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile Tyr 225 230 235 240 Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu Val 245 250 255 Phe Ala Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu Ala 260 265 270 Phe Gly Asn Asp Ser Thr Lys Trp Gin Lys Ile Glu Val Leu Thr Lys 275 280 285 Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr Lys 290 295 300 Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg 305 310 315 320 Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp Phe 325 330 335 Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin Lys 340 345 350 Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Ala 355 360 365 Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu 370 375 380 His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser Ile 385 390 395 400 Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser Ala 405 410 415 Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg 420 425 430 Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp Lys 435 440 445 Page 1699 of 3790 Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly 450 455 460 Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin Ser 465 470 475 480 Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile 485 490 495 Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val 500 505 510 Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile 515 520 525 Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala 530 535 540 Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asp 545 550 555 560 Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gin 565 570 575 Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe Thr 580 585 590 Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu 595 600 605 Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys 610 615 620 Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe Glu 625 630 635 640 Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg 645 650 655 Gin Arg Glu Asp Phe Lys Asn Glu Leu Arg Page 1700 of 3790 Met Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp Ala Phe Ser Glu 15 10 15 Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe Thr Lys Val Glu 20 25 30 Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg Arg Leu Ala Arg 35 40 45 Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg Leu Asn His Leu 50 55 60 Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr Glu Asp Tyr Gin 65 70 75 80 Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly Ser Leu Ile Ser 85 90 95 Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu Leu Ser Lys Gin 100 105 110 Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg Arg Gly Tyr Asp 115 120 125 Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala Ile Leu Lys Ala 130 135 140 Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin Ser Val Gly Glu 145 150 155 160 Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu Asn Ser Lys Glu 165 170 175 Phe Thr Asn Val Arg Asn Lys Lys Lys Val Met Asn Ala Ala 180 185 190 870 985 PRT Campylobacter jejuni 870 Met Ala Lys Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Val Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Page 1701 of 3790 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Thr Leu Ile Ser Pro Tyr Glu Leu Arg Phe Lys Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Leu Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asn Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Val Lys Glu Asn Glu Glu Lys Leu Ala Asn Tyr Lys 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Asn Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Val Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Glu Phe Val Ala Leu Thr Arg Ile Val 260 265 270 Asn Leu Leu Asn Asn Leu Asn Lys Asn Asn Ser Tyr Ile Lys Asp Asp 275 280 285 Page 1702 of 3790 Leu Asn Ala Leu Leu Ser Glu Val Leu Lys Asn Gly Thr Leu Thr Tyr 290 295 300 Lys Gin Thr Lys Lys Ile Leu Gly Leu Ser Asp Asp Tyr Glu Phe Lys 305 310 315 320 Gly Gin Lys Gly Asn Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu Phe 325 330 335 Ile Lys Ala Leu Cys Glu His Asn Leu Asn Gin Asp Asp Leu Asn Glu 340 345 350 Ile Ala Lys Asp Ile Thr Leu Val Lys Asp Glu Thr Lys Leu Lys Lys 355 360 365 Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Glu Asn Leu Ser 370 375 380 Lys Ile Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu Lys 385 390 395 400 Leu Ile Val Pro Leu Met Arg Glu Gly Lys Lys Tyr Asp Glu Val Cys 405 410 415 Asn Glu Leu Asn Leu Lys Thr Ala Ile Asn Glu Asp Lys Lys Glu Phe 420 425 430 Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Asn Asn Pro 435 440 445 Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Ser Leu 450 455 460 Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala Arg 465 470 475 480 Glu Val Gly Lys Asn His Arg Glu Arg Ser Lys Ile Glu Lys Glu Gin 485 490 495 Asn Glu Asn Phe Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Lys 500 505 510 Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe 515 520 525 Lys Glu Gin Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile Lys Ile Page 1704 of 3790 Leu His Glu Glu Thr Phe Tyr Lys Glu Glu Glu Phe Tyr Lys Glu Tyr 785 790 795 800 Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg 805 810 815 Lys Val Asn Gly Lys Ile Val Ser Asn Ala Asn Met Phe Arg Val Asp 820 825 830 Ile Phe Lys Tyr Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr 835 840 845 Thr Met Asp Phe Ala Leu Gly Ile Leu Pro Asn Lys Ala Val Val Gly 850 855 860 Gly Lys Asp Lys Gin Gly Ile Ile Lys Asp Trp Leu Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Leu 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Lys Ser Phe 900 905 910 Lys Ser Ser Thr Ala Gly Leu Val Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Asn Leu Asn Glu Asn Gin Lys Lys Leu Phe Lys Ser Ala Asn Glu 930 935 940 Lys Lys Val Val Ala Glu Gly Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Ile Thr Lys Ala Glu Ile 965 970 975 Lys Glu Arg Glu Asn Phe Lys Lys Lys 980 985 871 987 PRT Campylobacter jejuni 871 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Page 1705 of 3790 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Cys Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Glu 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Ser Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Lys Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Page 1706 of 3790 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asn Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Gin Lys Tyr Lys 325 330 335 Glu Phe Val Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Page 1707 of 3790 Leu Phe Lys Glu Gin Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Thr Phe Gly Asn Asp Arg Val Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Thr Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Thr 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Leu Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 872 987 PRT Campylobacter jejuni 872 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Page 1710 of 3790 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asn Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Page 1711 of 3790 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Page 1712 of 3790 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Val Gin Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 865 870 875 880 Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 885 890 895 Ile Leu Ile Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe 900 905 910 Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 915 920 925 Asn Lys Phe Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn 930 935 940 Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu 945 950 955 960 Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 965 970 975 Ala Glu Phe Arg Gin Arg Glu Asp Phe Lys Lys 980 985 873 961 PRT Campylobacter jejuni Page 1713 of 3790 873 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Thr Gin Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Ser Asp Glu Lys Arg Ala Pro Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Page 1715 of 3790 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Leu Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Asn Val Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Glu Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Lys Gly Ser Lys 660 665 670 Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Ala Leu Arg His 675 680 685 Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu His His Ala 690 695 700 Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser Ile Val Lys Asp 705 710 715 720 Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser Ala Glu Leu Tyr 725 730 735 Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg Lys Phe Phe 740 745 750 Page 1716 of 3790 Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp Lys Ile Asp Glu 755 760 765 Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala Leu His 770 775 780 Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin Ser Tyr Gly Gly 785 790 795 800 Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg Lys Val 805 810 815 Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val Asp Ile Phe 820 825 830 Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr Thr Met 835 840 845 Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala Arg Ser Lys 850 855 860 Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn Tyr Glu Phe 865 870 875 880 Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gin Thr Lys Asp 885 890 895 Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe Thr Ser Ser Thr 900 905 910 Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu Thr Leu Ser 915 920 925 Lys Asn Leu Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu 930 935 940 Val Thr Lys Ala Glu Phe Arg Gin Arg Glu Asp Phe Lys Asn Glu Leu 945 950 955 960 Arg 874 984 PRT Campylobacter jejuni 874 Page 1717 of 3790 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Thr Gin Ser Phe Leu Lys Tyr Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Page 1718 of 3790 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Page 1720 of 3790 Arg Lys Phe Phe Glu Pro Phe Ser 755 760 Gly Phe Arg Gin Lys Val Leu Asp 765 Lys Ile Asp Glu Ile Phe Val Ser 770 775 Lys Pro Glu Arg Lys Lys Pro Ser 780 Gly Ala Leu His Glu Glu Thr Phe 785 790 Arg Lys Glu Glu Glu Phe Tyr Gin 795 800 Ser Tyr Gly Gly Lys Glu Gly Val 805 Leu Lys Ala Leu Glu Leu Gly Lys 810 815 Ile Arg Lys Val Asn Gly Lys Ile 820 Val Lys Asn Gly Asp Met Phe Arg 825 830 Val Asp Ile Phe Lys His Lys Lys 835 840 Thr Asn Lys Phe Tyr Ala Val Pro 845 Ile Tyr Thr Met Asp Phe Ala Leu 850 855 Lys Val Leu Pro Asn Lys Ala Val 860 Ala Arg Ser Lys Lys Gly Glu Ile 865 870 Lys Asp Trp Ile Leu Met Asp Glu 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu 885 Tyr Lys Asp Ser Leu Ile Leu Ile 890 895 Gin Thr Lys Asp Met Gin Glu Pro 900 Glu Phe Val Tyr Tyr Asn Ala Phe 905 910 Thr Ser Ser Thr Val Ser Leu Ile 915 920 Val Ser Lys His Asp Asn Lys Phe 925 Glu Thr Leu Ser Lys Asn Gin Lys 930 935 Ile Leu Phe Lys Asn Ala Asn Glu 940 Lys Glu Val Ile Ala Lys Ser Ile 945 950 Gly Ile Gin Asn Leu Lys Val Phe 955 960 Glu Lys Tyr Ile Val Ser Ala Leu 965 Gly Glu Val Thr Lys Ala Glu Phe 970 975 Arg Gin Arg Glu Asp Phe Lys Lys 980 875 987 PRT Page 1721 of 3790 Campylobacter jejuni 875 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Gly Lys 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Ser Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 Page 1722 of 3790 His Leu Val Gly Asn Cys Ser Phe Leu Leu Met Lys Lys Glu Arg Gin 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Ala Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asn Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Gin Lys Tyr Lys 325 330 335 Glu Phe Val Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Page 1723 of 3790 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Thr Phe Gly Asn Asp Arg Val Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Thr Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Thr 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 965 970 975 Ala Glu Phe Arg Gin Arg Glu Asp Phe Lys Lys 980 985 Page 1725 of 3790 876 987 PRT Campylobacter jejuni 876 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Page 1726 of 3790 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asn Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Page 1727 of 3790 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Page 1728 of 3790 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Pro Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Val Gin Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 865 870 875 880 Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 885 890 895 Ile Leu Ile Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe 900 905 910 Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 915 920 925 Asn Lys Phe Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn 930 935 940 Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu 945 950 955 960 Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 965 970 975 Ala Glu Phe Arg Gin Arg Glu Asp Phe Lys Lys Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu Page 1731 of 3790 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Page 1732 of 3790 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe His Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Val Gin Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 865 870 875 880 Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 885 890 895 Ile Leu Ile Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe 900 905 910 Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 915 920 925 Asn Lys Phe Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn 930 935 940 Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu 945 950 955 960 Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys 965 970 975 Page 1733 of 3790 Page 1734 of 3790 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asn Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Page 1736 of 3790 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Val Gin Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 865 870 875 880 Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 885 890 895 Ile Leu Ile Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe 900 905 910 Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 915 920 925 Asn Lys Phe Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn 930 935 940 Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu 945 950 955 960 Page 1737 of 3790 Page 1738 of 3790 Arg Cys Ile Thr Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Page 1739 of 3790 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Leu Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Thr Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Glu Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His Page 1740 of 3790 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg Page 1741 of 3790 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Thr Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Ile Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Page 1742 of 3790 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ser 450 455 460 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Page 1743 of 3790 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Asn Gly Asp Glu Glu Lys Ser Glu 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Ile Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Thr Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Page 1744 of 3790 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Asp Glu His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Ile Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Ile Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys 545 Ile Ser Asp Leu Gin Asp 550 Glu Lys Met Leu Glu 555 Ile Asp His Ile 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Page 1745 of 3790 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Gly Val Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Glu Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Ala Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg Page 1747 of 3790 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Page 1748 of 3790 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Page 1749 of 3790 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Page 1750 of 3790 Page 1751 of 3790 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu Page 1753 of 3790 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Thr Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Glu Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Leu Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Page 1754 of 3790 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970 975 Arg Gin Arg Glu Asp Phe Lys Lys 980 884 984 PRT Campylobacter jejuni 884 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Page 1755 of 3790 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Page 1756 of 3790 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile Page 1758 of 3790 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970 975 Arg Gin Arg Glu Asp Phe Lys Lys 980 885 984 PRT Campylobacter jejuni 885 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Page 1759 of 3790 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Page 1760 of 3790 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Phe Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Page 1761 of 3790 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 980 886 987 PRT Campylobacter jejuni 886 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp Page 1764 of 3790 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ser Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Page 1765 of 3790 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Page 1766 of 3790 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Glu Lys Tyr Ile Val 965 Ser Ala Leu Gly Glu Val 970 Thr Lys Ala Glu 975 Phe Arg Gin Arg Glu 980 Asp Phe Lys Asn Glu Leu Arg 985 887 987 PRT Campylobacter jejuni Page 1767 of 3790 887 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Page 1769 of 3790 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Page 1770 of 3790 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970 975 Arg Gin Arg Glu Asp Phe Lys Asn Glu Leu Arg 980 985 888 983 Page 1771 of 3790 PRT Campylobacter jejuni 888 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 Page 1772 of 3790 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Page 1774 of 3790 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Phe Tyr Gin Ser 785 790 795 800 Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile 805 810 815 Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val 820 825 830 Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile 835 840 845 Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala 850 855 860 Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn 865 870 875 880 Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gin 885 890 895 Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr 900 905 910 Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu 915 920 925 Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys 930 935 940 Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe Glu 945 950 955 960 Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg 965 970 975 Gin Arg Glu Asp Phe Lys Lys 980 Page 1775 of 3790 889 987 PRT Campylobacter jejuni 889 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe 180 Thr Asn Val Arg Asn 185 Lys Lys Glu Ser Tyr Glu 190 Arg Cys Ile Ala Gin 195 Ser Phe Leu Lys Asp Glu Leu 200 Lys 205 Leu Ile Phe Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Page 1776 of 3790 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Page 1777 of 3790 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 965 970 975 Page 1779 of 3790 Arg Gin Arg Glu Asp Phe Lys Asn Glu Leu Arg 980 985 890 987 PRT Campylobacter jejuni 890 Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asn Ile Lys Asn Ser Asp Asn Glu Glu Lys Ser Glu 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Val Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe 180 Ile Asn Val Arg Asn 185 Lys Lys Glu Ser Tyr Glu 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Page 1780 of 3790 Gin Lys Gin Arg Glu Phe Gly Leu Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Val Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Page 1781 of 3790 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Asn Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Leu Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Thr Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Ile Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Page 1782 of 3790 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Val Gin Gly Lys Asp Lys Lys Ser Gly Leu Ile Lys Asp Trp Ile Leu 865 870 875 880 Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu 885 890 895 Ile Leu Ile Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr 900 905 910 Asn Ala Phe Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp 915 920 925 Asn Lys Phe Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn 930 935 940 Ala Asn Glu Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu 945 950 955 960 Lys Val Phe Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe Page 1784 of 3790 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Page 1785 of 3790 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Phe Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Page 1786 of 3790 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe 945 950 955 960 Page 1787 of 3790 Page 1788 of 3790 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Thr Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr Page 1789 of 3790 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Page 1790 of 3790 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Glu Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu 930 935 940 Page 1791 of 3790 Page 1792 of 3790 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Gin Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Page 1793 of 3790 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Page 1794 of 3790 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 915 920 925 Page 1795 of 3790 Page 1796 of 3790 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Asp His Ser Leu Asn Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Page 1797 of 3790 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn Tyr Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Val Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Page 1798 of 3790 Lys Gly Ser Lys Val Tyr Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 900 905 910 Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Page 1799 of 3790 Glu Phe 960 Phe Trp Phe Arg Arg Tyr Gly Leu Arg Ala Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin Page 1801 of 3790 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Tyr Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Page 1802 of 3790 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Gin Thr Lys Asp Met Gin Glu Pro Glu Leu Val Tyr Phe Asn Ala Phe 900 905 910 Page 1803 of 3790 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Page 1804 of 3790 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Page 1806 of 3790 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asn Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 865 870 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 885 890 895 Page 1807 of 3790 Page 1808 of 3790 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Page 1809 of 3790 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr Page 1811 of 3790 Page 1812 of 3790 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Thr Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Page 1813 of 3790 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Page 1814 of 3790 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Page 1817 of 3790 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Page 1818 of 3790 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 835 840 845 Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 850 855 860 Page 1819 of 3790 Page 1820 of 3790 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Val Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Gin Thr Pro Phe Glu 580 585 590 Page 1822 of 3790 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 740 745 750 Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gin Lys Val Leu Asp 755 760 765 Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 770 775 780 Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin 785 790 795 800 Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 805 810 815 Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 820 825 830 Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Gly Val Pro 835 840 845 Page 1823 of 3790 Page 1824 of 3790 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Page 1825 of 3790 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu Page 1827 of 3790 Val Asp Ile Phe Lys His Lys Lys 835 840 Thr Asn Lys Phe Tyr Ala Val Pro 845 Ile Tyr Thr Met Asp Phe Ala Leu 850 855 Lys Val Leu Pro Asn Lys Ala Val 860 Ala Arg Ser Lys Lys Gly Glu Ile 865 870 Lys Asp Trp Ile Leu Met Asp Glu 875 880 Asn Tyr Glu Phe Cys Phe Ser Leu 885 Tyr Lys Asp Ser Leu Ile Leu Ile 890 895 Gin Thr Lys Asp Met Gin Glu Pro 900 Glu Phe Val Tyr Tyr Asn Ala Phe 905 910 Thr Ser Ser Thr Val Ser Leu Ile 915 920 Val Ser Lys His Asp Asn Lys Phe 925 Glu Thr Leu Ser Lys Asn Gin Lys 930 935 Ile Leu Phe Lys Asn Ala Asn Glu 940 Lys Glu Val Ile Ala Lys Ser Ile 945 950 Gly Ile Gin Asn Leu Lys Val Phe 955 960 Glu Lys Tyr Ile Val Ser Ala Leu 965 Gly Glu Val Thr Lys Ala Glu Phe 970 975 Arg Gin Arg Glu Asp Phe Lys Lys 980 Ile Asn Leu Leu Asn Asn Leu Lys 10 15 Asn Thr Glu Gly Ile Leu Tyr Thr 20 Asn Glu Val Leu Lys Asn Gly Thr 35 40 Leu Leu Gly Leu Ser Asp Asp Tyr 50 55 Lys Asp Asp Leu Asn Thr Leu Leu 25 30 Leu Thr Tyr Lys Gin Thr Lys Lys 45 Glu Phe Lys Gly Glu Lys Gly Thr 60 Page 1828 of 3790 Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu Phe Ile Lys Ala Leu Gly 65 70 75 80 Asp His Ser Leu Ser Gin Asp Asp Leu Asn Glu Ile Ala Lys Asp Ile 85 90 95 Thr Leu Ile Lys Asp Glu Ile Lys Leu Lys Lys Ala Leu Ala Lys Tyr 100 105 110 Asp Leu Asn Gin Asn Gin Ile Asp Ser Leu Ser Lys Leu Glu Phe Lys 115 120 125 Asp His Leu Asn Ile Ser Phe Lys Ala Leu Lys Leu Ile Thr Pro Leu 130 135 140 Met Leu Glu Gly Lys Lys Tyr Asp Glu Ala Cys Asn Glu Leu Asn Leu 145 150 155 160 Lys Val Ala Ile Asn Glu Asp Lys Lys Asp Phe Leu Pro Ala Phe Asn 165 170 175 Glu Thr Tyr Tyr Lys Asp Glu Val Thr Asn Pro Val Val Leu Arg Ala 180 185 190 Ile Lys Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu Lys Lys Tyr Gly 195 200 205 Lys Val His Lys Ile Asn Ile Glu Leu Ala Arg Glu Val Gly Lys Asn 210 215 220 Tyr Ser Gin Arg Ala Lys Ile Glu Lys Glu Gin Asn Glu Asn Tyr Lys 225 230 235 240 Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Lys Leu Gly Leu Lys Ile 245 250 255 Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe Lys Glu Gin Lys Glu 260 265 270 Phe Cys Ala Tyr Ser Gly Glu Lys Ile Lys Ile Ser Asp Leu Gin Asp 275 280 285 Glu Lys Met Leu Glu Ile Asp His Ile Tyr Pro Tyr Ser Arg Ser Phe 290 295 300 Asp Asp Ser Tyr Met Asn Lys Val Leu Val Phe Thr Lys Gin Asn Gin 305 310 315 320 Page 1829 of 3790 Glu Lys Leu Asn Gin Thr Pro Phe Glu Ala Phe Gly Asn Asp Ser Ala 325 330 335 Lys Trp Gin Lys Ile Glu Val Leu Ala Lys Asn Leu Pro Thr Lys Lys 340 345 350 Gin Lys Arg Ile Leu Asp Lys Asn Tyr Lys Asp Lys Glu Gin Lys Asp 355 360 365 Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Leu Val 370 375 380 Leu Asn Tyr Thr Lys Asp Tyr Leu Asp Phe Leu Pro Leu Ser Asp Asp 385 390 395 400 Glu Asn Thr Lys Leu Asn Asn Thr Gin Lys Gly Ser Lys Val Tyr Val 405 410 415 Glu Ala Lys Ser Gly Met Leu Thr Ser Ala Leu Arg His Thr Trp Gly 420 425 430 Phe Ser Thr Lys Asp Arg Asn Asn His Leu His His Ala Ile Asp Ala 435 440 445 Val Ile Ile Ala Tyr Ala Asn Asn Ser Ile Val Lys Ala Phe Ser Asp 450 455 460 Phe Lys Lys Glu Gin Glu Ser Asn Ser Ala Glu Leu Tyr Ala Lys Lys 465 470 475 480 Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg Lys Phe Phe Glu Pro Phe 485 490 495 Ser Gly Phe Arg Gin Lys Val Leu Asp Lys Ile Asp Glu Ile Phe Val 500 505 510 Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala Leu His Glu Glu Thr 515 520 525 Phe Arg Lys Glu Glu Glu Phe Tyr Gin Ser Tyr Gly Gly Lys Glu Gly 530 535 540 Val Leu Lys Ala Leu Glu Leu Gly Lys Ile Arg Lys Val Asn Gly Lys 545 550 555 560 Ile Val Lys Asn Gly Asp Met Phe Arg Val Asp Ile Phe Lys His Lys 565 570 575 Page 1830 of 3790 Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile Tyr Thr Met Asp Phe Ala 580 585 590 Leu Lys Val Leu Pro Asn Lys Ala Val Ala Arg Ser Lys Lys Gly Glu 595 600 605 Ile Lys Asp Trp Ile Leu Met Asp Glu Asn Tyr Glu Phe Cys Phe Ser 610 615 620 Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gin Thr Lys Asp Met Gin Glu 625 630 635 640 Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr Ser Ser Thr Val Ser Leu 645 650 655 Ile Val Ser Lys His Asp Asn Lys Phe Glu Thr Leu Ser Lys Asn Gin 660 665 670 Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys Glu Val Ile Ala Lys Ser 675 680 685 Ile Gly Ile Gin Asn Leu Lys Val Phe Glu Lys Tyr Ile Val Ser Ala 690 695 700 Leu Gly Glu Val Thr Lys Ala Glu Phe Arg Gin Arg Glu Asp Phe Lys 705 710 715 720 Lys 903 512 PRT Campylobacter jejuni 903 Met His Lys Ile Asn Ile Glu Leu Ala Arg Glu Val Gly Lys Asn His 15 10 15 Ser Gin Arg Ala Lys Ile Glu Lys Glu Gin Asn Glu Asn Tyr Lys Ala 20 25 30 Lys Lys Asp Ala Glu 35 Ile Glu Cys 40 Glu Lys Leu Gly Leu 45 Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu Phe Lys Glu Gin Lys Glu Phe 50 55 60 Page 1831 of 3790 Cys Ala Tyr Ser Gly Glu Lys Ile Lys Leu Ser Asp Leu Gin Asp Glu 65 70 75 80 Lys Met Leu Glu Ile Asp His Ile Tyr Pro Tyr Ser Arg Ser Phe Asp 85 90 95 Asp Ser Tyr Met Asn Lys Val Leu Val Phe Thr Lys Gin Asn Gin Glu 100 105 110 Lys Leu Asn Lys Thr Pro Phe Glu Ala Phe Gly Asn Asp Ser Thr Lys 115 120 125 Trp Gin Lys Ile Glu Val Leu Ala Lys Asn Leu Pro Glu Lys Lys Gin 130 135 140 Lys Arg Ile Leu Asp Lys Asn Tyr Lys Asp Lys Glu Gin Lys Asp Phe 145 150 155 160 Lys Asp Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Leu Val Leu 165 170 175 Asn Tyr Thr Lys Asp Tyr Leu Asp Phe Leu Pro Leu Ser Asp Asp Glu 180 185 190 Asn Thr Lys Leu Asn Asp Thr Gin Lys Gly Ser Lys Val His Val Glu 195 200 205 Ala Lys Ser Gly Met Leu Thr Ser Ala Leu Arg His Thr Trp Gly Phe 210 215 220 Ser Ala Lys Asp Arg Asn Asn His Leu His His Ala Ile Asp Ala Ala 225 230 235 240 Ile Ile Ala Tyr Ala Asn Asn Ser Ile Val Lys Ala Phe Ser Asp Phe 245 250 255 Lys Lys Glu Gin Glu Ser Asn Ser Val Glu Leu Tyr Ala Lys Lys Ile 260 265 270 Ser Glu Leu Asp Tyr Lys Asn Lys Arg Lys Phe Phe Glu Pro Phe Ser 275 280 285 Gly Phe Arg Gin Lys Val Leu Asp Lys Ile Asp Glu Ile Phe Val Ser 290 295 300 Lys Pro Glu Arg Lys Lys Pro Ser Gly Ala Leu His Glu Glu Thr Phe Leu Arg Glu Asn Asp Glu Ile Ile Asp Cys Gly Val Arg Val Phe Asp Page 1833 of 3790 Ile Pro Glu Asn Pro Lys Asn Gly Asn Ser Leu Ala Leu Glu Arg Arg 35 40 45 Glu Asn Lys Ala Arg Met Lys Ile Val Lys Arg Lys Lys Ala Arg Met 50 55 60 Leu Ala Thr Lys Thr Phe Leu Lys Lys Glu Leu Asn Val Asp Leu Ser 65 70 75 80 Lys Leu Phe Leu Ile Gly Ser Thr Gin Ser Ile Tyr Glu Leu Arg Ala 85 90 95 Lys Ala Leu Ser Ser Leu Ile Ser Lys Glu Glu Leu Ser Ala Ile Ile 100 105 110 Leu His Ile Ala Lys His Arg Gly Tyr Asp Asp Ser Ala Leu Lys Asn 115 120 125 Glu Asn Gly Thr Ile Ile Glu Ala Leu Asn Lys Asn Lys Glu Thr Met 130 135 140 Leu Lys Phe Lys Ser Val Gly Glu Tyr Phe Tyr Lys Asn Phe Val Gin 145 150 155 160 Asn Lys Glu Val Lys Lys Ile Arg Asn Thr Thr Glu Asp Tyr Ser Asn 165 170 175 Ser Val Pro Arg Ser Leu Leu Lys Gin Glu Leu Asp Leu Ile Leu Asp 180 185 190 Lys Gin Lys Glu Leu Gly Leu Ile Lys Asn Ala Asp Phe Lys Glu Lys 195 200 205 Leu Phe Glu Ile Ile Phe Phe Lys Arg Pro Leu Lys Asp Phe Ser Asn 210 215 220 Lys Ile Gly Asn Cys Ile Phe Phe Glu Asn Glu Lys Arg Ala Ala Lys 225 230 235 240 Asn Thr Ile Ser Ala Cys Glu Phe Val Ala Leu Gly Lys Val Val Asn 245 250 255 Leu Leu Lys Ser Ile Glu Lys Asp Ile Gly Ile Val Tyr Glu Lys Asp 260 265 270 Page 1834 of 3790 Ser Ile Asn Glu Ile Met Ser Ile Ile Leu Asp Lys Thr Ser Ile Ser 275 280 285 Tyr Lys Lys Ile Arg Asp Ile Leu Asn Leu Pro Gin Glu Ile Asn Phe 290 295 300 Lys Gly Leu Asp Tyr Ser Lys Asn Asn Val Glu Asn Ser Lys Leu Val 305 310 315 320 Asp Leu Lys Lys Leu Asn Glu Phe Lys Lys Ala Leu Gly Asp Gly Phe 325 330 335 Ala Asn Leu Asp Lys Asp Ile Leu Asp Ser Ile Ala Thr Asp Ile Thr 340 345 350 Leu Thr Lys Asp Thr Ala Thr Leu Lys Glu Lys Leu Lys Asn Tyr Asn 355 360 365 Val Leu Asn Ala Glu Gin Ile Glu Lys Leu Ser Glu Leu Val Phe Asn 370 375 380 Asp His Ile Asn Leu Ser Leu Lys Ala Leu Lys Gin Ile Ile Pro Leu 385 390 395 400 Met Tyr Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Leu Cys Asn Phe 405 410 415 Thr Ile Ala Lys Asn Gin Glu Lys Ser Glu Tyr Leu Pro Leu Phe Glu 420 425 430 Lys Thr Arg Phe Ala Lys Asp Ile Ser Ser Pro Val Val Ile Arg Ala 435 440 445 Ile Cys Glu Phe Arg Lys Leu Leu Asn Asp Ile Ile Arg Arg Tyr Gly 450 455 460 Ser Val His Lys Ile His Leu Glu Leu Thr Arg Asp Phe Gly Ile Ser 465 470 475 480 Phe Ser Asp Arg Lys Lys Ile Ile Lys Glu Ile Glu Gin Asn Glu Gin 485 490 495 Ser Arg Ile Lys Ala Leu Glu Thr Ile Lys Glu Leu Lys Leu Glu Glu 500 505 510 Thr Ser Lys Asn Ile Gin Ile Val Arg Leu Phe Glu Asp Gin Lys Gly 515 520 525 Page 1835 of 3790 Ile Cys Pro Tyr Ser Gly Leu Lys Met Asp Leu Asn Arg Leu Asp Glu 530 535 540 Leu Val Ile Asp Tyr Ile Arg Pro Tyr Asn Arg Ser Leu Asp Asp Ser 545 550 555 560 Tyr Ser Asn Lys Val Leu Thr Phe Lys Lys Leu Ser Asp Leu Lys Gin 565 570 575 Gly Lys Thr Pro Phe Glu Ala Phe Gly Glu Asp Glu Lys Leu Trp Ala 580 585 590 Glu Ile Asn Glu Arg Ile Lys Glu Tyr Asn Gly Lys Lys Arg Phe Lys 595 600 605 Ile Phe Asp Lys Phe Phe Lys Asp Lys Lys Pro Phe Asp Phe Thr Glu 610 615 620 Gin Thr Leu Gin Asp Thr Arg Trp Leu Thr Lys Leu Val Ala Ser Tyr 625 630 635 640 Leu Asn Glu Tyr Leu Ser Phe Leu Pro Ile Ser Glu Asp Glu Asn Thr 645 650 655 Ala Leu Gly Tyr Gly Glu Lys Gly Ser Lys Gin His Val Ile Leu Ser 660 665 670 Ser Gly Met Ile Thr Gin Met Leu Arg Asn Phe Trp Tyr Leu Gly Phe 675 680 685 Lys Asn His Lys Asp Tyr Lys Asn Asn Ala Met Asp Ala Ile Ile Val 690 695 700 Ala Phe Thr Thr Asn Ser Ile Ile Phe Ala Phe Asn Asn Phe Lys Lys 705 710 715 720 Glu Leu Asp Leu Ala Lys Ala Glu Phe Tyr Ala Asn Lys Ile Ser Glu 725 730 735 Ser Asp Tyr Leu Leu Lys Arg Lys Phe Leu Pro Pro Phe Ser Gly Phe 740 745 750 Lys Glu Gin Ala Leu Glu Lys Val Lys Asn Ile Phe Val Ser His Ser 755 760 765 Leu Lys Ile Lys Asn Lys Gly Thr Leu His Asp Leu Thr Pro Leu Lys 770 775 780 Page 1836 of 3790 Ile Lys Glu Leu Lys Asn Thr Tyr Gly Asp Leu Asp Leu Ala Val Lys 785 790 795 800 Leu Gly Lys Ile Arg Lys Tyr Asn Asp Lys Tyr Tyr Ala Asn Ala Asn 805 810 815 Gly Ser Leu Val Arg Ala Asp Leu Phe Val Asp Lys Lys Asn Lys Phe 820 825 830 His Ala Val Ser Ile Tyr Lys Ala Asp Phe Ser Thr Lys Lys Leu Pro 835 840 845 Asn Lys Thr Pro Ala Thr Thr Ser Asn Gly Glu Thr Lys Glu Gly Ile 850 855 860 Glu Met Asn Glu Asn Tyr Asn Phe Cys Met Ser Leu Tyr Lys Asn Thr 865 870 875 880 Pro Ile Ser Val Lys Ile Lys Gly Met Lys Glu Pro Ile Ile Cys Tyr 885 890 895 Tyr His Gly Phe Asn Thr Ser Gly Ser Lys Ile Thr Tyr Lys Lys His 900 905 910 Asp Asn Asn Tyr His Asn Leu Ser Glu Asp Glu Met Val Val Phe Arg 915 920 925 Lys Asn Asp Lys Glu Ser Ile Ala Val Gly Lys Ile Leu Glu Ile Lys 930 935 940 Lys Tyr Ser Ile Ser Pro Ser Gly Glu Leu Ser Leu Ile Glu Asn Glu 945 950 955 960 Glu Arg Lys Trp Phe 965 905 759 PRT Campylobacter jejuni 905 Met Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser His 15 10 15 Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro Lys 20 25 30 Page 1837 of 3790 Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile Asn 35 40 45 Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys Asp 50 55 60 Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu Thr 65 70 75 80 Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu Phe 85 90 95 Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys Glu 100 105 110 Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu Asn 115 120 125 Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu Lys 130 135 140 Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser Leu 145 150 155 160 Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala Leu 165 170 175 Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu Ala 180 185 190 Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys Asp 195 200 205 Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr Asn 210 215 220 Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn Ala 225 230 235 240 Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu Ala 245 250 255 Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys Glu 260 265 270 Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys Glu Page 1838 of 3790 275 280 285 Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg Leu 290 295 300 Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile Lys 305 310 315 320 Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile Tyr 325 330 335 Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu Val 340 345 350 Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu Ala 355 360 365 Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala Lys 370 375 380 Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr Lys 385 390 395 400 Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr Arg 405 410 415 Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp Phe 420 425 430 Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin Lys 435 440 445 Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser Ala 450 455 460 Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His Leu 465 470 475 480 His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser Ile 485 490 495 Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser Ala 500 505 510 Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys Arg 515 520 525 Page 1839 of 3790 Lys Phe Phe Glu Ser Phe Ser Gly Phe Arg Gin Lys Val Leu Asp Lys 530 535 540 Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser Gly 545 550 555 560 Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gin Ser 565 570 575 Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys Ile 580 585 590 Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg Val 595 600 605 Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro Ile 610 615 620 Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val Ala 625 630 635 640 Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu Asn 645 650 655 Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile Gin 660 665 670 Thr Lys Asp Met Gin Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe Thr 675 680 685 Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe Glu 690 695 700 Thr Leu Ser Lys Asn Gin Lys Ile Leu Phe Lys Asn Ala Asn Glu Lys 705 710 715 720 Glu Val Ile Ala Lys Ser Ile Gly Ile Gin Asn Leu Lys Val Phe Glu 725 730 735 Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe Arg 740 745 750 Gin Arg Glu Asp Phe Lys Lys 755 906 984 PRT Page 1840 of 3790 Campylobacter jejuni 906 Met Val Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 15 10 15 Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 20 25 30 Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 35 40 45 Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 50 55 60 Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 65 70 75 80 Glu Asp Tyr Gin Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 85 90 95 Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 100 105 110 Leu Ser Lys Gin Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 115 120 125 Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 130 135 140 Ile Leu Lys Ala Ile Lys Gin Asn Glu Glu Lys Leu Ala Asn Tyr Gin 145 150 155 160 Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gin Lys Phe Lys Glu 165 170 175 Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 180 185 190 Arg Cys Ile Ala Gin Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 195 200 205 Lys Lys Gin Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 210 215 220 Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 225 230 235 240 Page 1841 of 3790 His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 245 250 255 Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 260 265 270 Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 275 280 285 Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 290 295 300 Thr Tyr Lys Gin Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 305 310 315 320 Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 325 330 335 Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gin Asp Asp Leu 340 345 350 Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 355 360 365 Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gin Asn Gin Ile Asp Ser 370 375 380 Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 385 390 395 400 Leu Lys Leu Ile Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 405 410 415 Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 420 425 430 Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 435 440 445 Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 450 455 460 Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 465 470 475 480 Ala Arg Glu Val Gly Lys Asn His Ser Gin Arg Ala Lys Ile Glu Lys 485 490 495 Page 1842 of 3790 Glu Gin Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 500 505 510 Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 515 520 525 Leu Phe Lys Glu Gin Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 530 535 540 Lys Ile Ser Asp Leu Gin Asp Glu Lys Met Leu Glu Ile Asp His Ile 545 550 555 560 Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 565 570 575 Val Phe Thr Lys Gin Asn Gin Glu Lys Leu Asn Lys Thr Pro Phe Glu 580 585 590 Ala Phe Gly Asn Asp Ser Ala Lys Trp Gin Lys Ile Glu Val Leu Ala 595 600 605 Lys Asn Leu Pro Thr Lys Lys Gin Lys Arg Ile Leu Asp Lys Asn Tyr 610 615 620 Lys Asp Lys Glu Gin Lys Asp Phe Lys Asp Arg Asn Leu Asn Asp Thr 625 630 635 640 Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 645 650 655 Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gin 660 665 670 Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 675 680 685 Ala Leu Arg His Thr Trp Gly Phe Ser Thr Lys Asp Arg Asn Asn His 690 695 700 Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 705 710 715 720 Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gin Glu Ser Asn Ser 725 730 735 Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 965 970 975 Arg Gin Arg Glu Asp Phe Lys Lys 980 Page 1844 of 3790 907 1003 PRT Campylobacter lari] 907 Page 1845 of 3790 Asn Glu Ile Leu Lys Val Ala Phe Phe Gin Arg Pro Leu Lys Asp Phe 225 230 235 240 Ser His Leu Val Gly Ala Cys Thr Phe Phe Glu Glu Glu Lys Arg Ala 245 250 255 Cys Lys Asn Ser Tyr Ser Ala Trp Glu Phe Val Ala Leu Thr Lys Ile 260 265 270 Ile Asn Glu Ile Lys Ser Leu Glu Lys Ile Ser Gly Glu Ile Val Pro 275 280 285 Thr Gin Thr Ile Asn Glu Val Leu Asn Leu Ile Leu Asp Lys Gly Ser 290 295 300 Ile Thr Tyr Lys Lys Phe Arg Ser Cys Ile Asn Leu His Glu Ser Ile 305 310 315 320 Ser Phe Lys Ser Leu Lys Tyr Asp Lys Glu Asn Ala Glu Asn Ala Lys 325 330 335 Leu Ile Asp Phe Arg Lys Leu Val Glu Phe Lys Lys Ala Leu Gly Val 340 345 350 His Ser Leu Ser Arg Gin Glu Leu Asp Gin Ile Ser Thr His Ile Thr 355 360 365 Leu Ile Lys Asp Asn Val Lys Leu Lys Thr Val Leu Glu Lys Tyr Asn 370 375 380 Leu Ser Asn Glu Gin Ile Asn Asn Leu Leu Glu Ile Glu Phe Asn Asp 385 390 395 400 Tyr Ile Asn Leu Ser Phe Lys Ala Leu Gly Met Ile Leu Pro Leu Met 405 410 415 Arg Glu Gly Lys Arg Tyr Asp Glu Ala Cys Glu Ile Ala Asn Leu Lys 420 425 430 Pro Lys Thr Val Asp Glu Lys Lys Asp Phe Leu Pro Ala Phe Cys Asp 435 440 445 Ser Ile Phe Ala His Glu Leu Ser Asn Pro Val Val Asn Arg Ala Ile 450 455 460 Ser Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu Lys Lys Tyr Gly Lys 465 470 475 480 Page 1846 of 3790 Val His Lys Ile His Leu Glu Leu Ala Arg Asp Val Gly Leu Ser Lys 485 490 495 Lys Ala Arg Glu Lys Ile Glu Lys Glu Gin Lys Glu Asn Gin Ala Val 500 505 510 Asn Ala Trp Ala Leu Lys Glu Cys Glu Asn Ile Gly Leu Lys Ala Ser 515 520 525 Ala Lys Asn Ile Leu Lys Leu Lys Leu Trp Lys Glu Gin Lys Glu Ile 530 535 540 Cys Ile Tyr Ser Gly Asn Lys Ile Ser Ile Glu His Leu Lys Asp Glu 545 550 555 560 Lys Ala Leu Glu Val Asp His Ile Tyr Pro Tyr Ser Arg Ser Phe Asp 565 570 575 Asp Ser Phe Ile Asn Lys Val Leu Val Phe Thr Lys Glu Asn Gin Glu 580 585 590 Lys Leu Asn Lys Thr Pro Phe Glu Ala Phe Gly Lys Asn Ile Glu Lys 595 600 605 Trp Ser Lys Ile Gin Thr Leu Ala Gin Asn Leu Pro Tyr Lys Lys Lys 610 615 620 Asn Lys Ile Leu Asp Glu Asn Phe Lys Asp Lys Gin Gin Glu Asp Phe 625 630 635 640 Ile Ser Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Thr Leu Ile Ala 645 650 655 Lys Tyr Thr Lys Glu Tyr Leu Asn Phe Leu Leu Leu Ser Glu Asn Glu 660 665 670 Asn Ala Asn Leu Lys Ser Gly Glu Lys Gly Ser Lys Ile His Val Gin 675 680 685 Thr Ile Ser Gly Met Leu Thr Ser Val Leu Arg His Thr Trp Gly Phe 690 695 700 Asp Lys Lys Asp Arg Asn Asn His Leu His His Ala Leu Asp Ala Ile 705 710 715 720 Ile Val Ala Tyr Ser Thr Asn Ser Ile Ile Lys Ala Phe Ser Asp Phe 725 730 735 Page 1847 of 3790 Arg Lys Asn Gin Glu Leu Leu Lys Ala Arg Phe Tyr Ala Lys Glu Leu 740 745 750 Thr Ser Asp Asn Tyr Lys His Gin Val Lys Phe Phe Glu Pro Phe Lys 755 760 765 Ser Phe Arg Glu Lys Ile Leu Ser Lys Ile Asp Glu Ile Phe Val Ser 770 775 780 Lys Pro Pro Arg Lys Arg Ala Arg Arg Ala Leu His Lys Asp Thr Phe 785 790 795 800 His Ser Glu Asn Lys Ile Ile Asp Lys Cys Ser Tyr Asn Ser Lys Glu 805 810 815 Gly Leu Gin Ile Ala Leu Ser Cys Gly Arg Val Arg Lys Ile Gly Thr 820 825 830 Lys Tyr Val Glu Asn Asp Thr Ile Val Arg Val Asp Ile Phe Lys Lys 835 840 845 Gin Asn Lys Phe Tyr Ala Ile Pro Ile Tyr Ala Met Asp Phe Ala Leu 850 855 860 Gly Ile Leu Pro Asn Lys Ile Val Ile Thr Gly Lys Asp Lys Asn Asn 865 870 875 880 Asn Pro Lys Gin Trp Gin Thr Ile Asp Glu Ser Tyr Glu Phe Cys Phe 885 890 895 Ser Leu Tyr Lys Asn Asp Leu Ile Leu Leu Gin Lys Lys Asn Met Gin 900 905 910 Glu Pro Glu Phe Ala Tyr Tyr Asn Asp Phe Ser Ile Ser Thr Ser Ser 915 920 925 Ile Cys Val Glu Lys His Asp Asn Lys Phe Glu Asn Leu Thr Ser Asn 930 935 940 Gin Lys Leu Leu Phe Ser Asn Ala Lys Glu Gly Ser Val Lys Val Glu 945 950 955 960 Ser Leu Gly Ile Gin Asn Leu Lys Val Phe Glu Lys Tyr Ile Ile Thr 965 970 975 Pro Leu Gly Asp Lys Ile Lys Ala Asp Phe Gin Pro Arg Glu Asn Ile Gin Gin Ile Ile Lys Val Lys Leu Tyr Arg Glu Gin Gin Gly Lys Cys Page 1849 of 3790 25 30 Thr Gly Ser Arg Ile Ile Pro Met Asp Gin Gly Ile Leu Gly Asp Phe Page 1850 of 3790 40 45 Glu Arg Gly Asn Thr Val Ser Gin Thr Ala Glu Arg Thr Thr Tyr Arg 50 55 60 Ser Met Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 His Arg Val Leu His Leu Leu Gly Phe Leu Pro Pro His Tyr Asp Ala 85 90 95 Gin Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe Ile Asp Asn Ala Glu 100 105 110 Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile Phe Met Asn Ser Phe 115 120 125 Asn Glu Met Val Glu Asp Phe Lys Lys His Gin Pro Gin Leu Phe Tyr 130 135 140 Lys Lys Ser Asn Gly Glu Glu Ser Arg Ile Pro Tyr Asp Trp Thr Ile 145 150 155 160 Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gin Lys Ile Thr Gin Gin Glu 165 170 175 Leu Ala Trp Leu Ile Leu His Phe Asn Gin Lys Arg Gly Tyr Tyr Gin 180 185 190 Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn Lys Glu Val Ala Phe 195 200 205 His Ser Leu Lys Val Val Asp Val Glu Ala Glu Ala Pro Asn Lys Lys 210 215 220 Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn Gly Trp Ile Tyr Arg 225 230 235 240 Arg Thr Ser Lys Asn Pro Leu Asp Asp Trp Lys Gly Lys Thr Arg Asp 245 250 255 Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly Thr Ile Lys Leu Asp 260 265 270 Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala Pro Asp Glu Asn Asp 275 280 285 Page 1851 of 3790 Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp Ile Asp Phe Ser Gly 290 295 300 Lys Pro Val Gly Thr Tyr Ile Tyr Asp His Leu Leu Gin Asn Pro Asn 305 310 315 320 Gin Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 325 330 335 Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gin Ile Ala Leu Gin Pro 340 345 350 Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys Ile Arg Glu Leu Tyr 355 360 365 Arg Lys Asn Glu Thr Gin Gin Gin Asn Leu Leu Ser Lys Asp Phe Leu 370 375 380 His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gin Arg Pro Leu Cys Ser 385 390 395 400 Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu Lys Arg Ser Tyr Ile 405 410 415 Asp Lys Glu Thr Asn Glu Arg Lys Asp Ala Pro Ile Lys Val Cys Ala 420 425 430 Lys Ser Asn Pro Tyr Tyr Gin Glu Phe Arg Val Leu Gin Trp Leu Gin 435 440 445 Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg Glu Val Thr Ala Glu 450 455 460 Phe Ile Glu Thr Pro Gin Asp Tyr Glu Ala Leu Phe Asn Phe Leu Met 465 470 475 480 Ser Gin Lys Glu Ile Asp Asn Glu Gly Leu Leu Lys Tyr Phe Leu Phe 485 490 495 Ala Lys Asn Pro Gin Ile Lys Asp Lys Ala Ala Lys Ser Glu Leu Lys 500 505 510 Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Ala Asp 515 520 525 Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr Gly Tyr Glu Leu Gin 530 535 540 Page 1852 of 3790 Arg Tyr Leu Gin Lys Val Glu Gly Leu Pro Ala Asn Phe Leu Thr Phe 545 550 555 560 Asp Ile Thr Tyr Gin Leu Trp His Leu Leu Tyr Ser Val Lys Asp Lys 565 570 575 Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala Lys Lys Lys Gin Leu 580 585 590 Asp Lys Thr Ser Phe Val Asp Ser Phe Lys Asn Phe Lys Pro Tyr Pro 595 600 605 Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro 610 615 620 Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn Arg Ile Asp Val Ser 625 630 635 640 Thr Gin Lys Arg Ile Asp Asp Leu Ile Asn Gly Val Ala Asn Glu Asp 645 650 655 Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys Tyr Gin Leu Asn Ser 660 665 670 Glu Thr Cys Phe Gin Asp Leu Pro Leu Trp Leu Ala Gin Tyr Val Val 675 680 685 Tyr Asn Arg His Ala Glu Ala Thr Asp Ile Glu Lys Trp Thr Ser Val 690 695 700 Ser Asp Leu Glu Ala Tyr Leu Glu Asp Phe Lys Gin His Ser Leu Arg 705 710 715 720 Asn Pro Ile Val Glu Gin Val Val Thr Glu Thr Leu Arg Val Val Arg 725 730 735 Asp Ile Trp Gin Gin Tyr Ser Gly Gly Gin Ala Asn Phe Phe Asp Glu 740 745 750 Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys Thr Ala Glu Glu Arg 755 760 765 Lys Gin Leu Ser Asp Lys Asn Gin Glu Asn Glu Asn Thr Asn Leu Arg 770 775 780 Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp Ala Ser Ile Gin Asn 785 790 795 800 Page 1853 of 3790 Thr Gin Leu Phe Thr Ser Tyr Asn Asp Arg Leu Gin Lys Asn Leu Page 1854 of 3790 1040 1045 1050 His Gin Pro Ile Tyr Lys Val Arg Ile Phe Glu Glu Gly Ser Lys Phe 130 135 Page 1855 of 3790 140 Gly Lys Ile Ile Ala Thr Gly Ser Arg Ile Ile Pro Met Asp Gin Gly Page 1856 of 3790 55 60 Ile Leu Gly Asp Phe Glu Arg Gly Asn Thr Val Ser Gin Thr Ala Glu 65 70 75 80 Arg Thr Thr Tyr Arg Ser Thr Arg Arg Leu Arg Glu Arg His Leu Leu 85 90 95 Arg Arg Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro 100 105 110 Pro His Tyr Asp Ala Gin Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe 115 120 125 Ile Asp Asn Ala Glu Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile 130 135 140 Phe Met Asn Ser Phe Asn Glu Met Ile Glu Asp Phe Lys Lys His Gin 145 150 155 160 Pro Gin Leu Phe Tyr Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro 165 170 175 Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gin Lys 180 185 190 Ile Thr Gin Gin Glu Leu Ala Trp Leu Ile Leu His Phe Asn Gin Lys 195 200 205 Arg Gly Tyr Tyr Gin Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn 210 215 220 Lys Glu Val Ala Phe His Ser Leu Lys Val Val Asp Val Glu Ala Glu 225 230 235 240 Ala Pro Asn Lys Lys Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn 245 250 255 Gly Trp Ile Tyr Arg Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys 260 265 270 Gly Lys Thr Arg Asp Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly 275 280 285 Thr Ile Lys Val Asp Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala 290 295 300 Page 1857 of 3790 Pro Asp Glu Asn Asp Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp 305 310 315 320 Ile Asp Phe Ser Gly Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu 325 330 335 Leu Gin Asn Pro Asn Gin Lys Ile Lys Gly Lys Leu Val Arg Thr Ile 340 345 350 Glu Arg Lys Tyr Tyr Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gin 355 360 365 Ile Ala Leu Gin Pro Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys 370 375 380 Ile Arg Glu Leu Tyr Arg Lys Asn Glu Thr Gin Gin Gin Asn Leu Leu 385 390 395 400 Ser Lys Asp Phe Leu His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gin 405 410 415 Arg Pro Leu Arg Ser Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu 420 425 430 Lys Arg Ser Tyr Ile Asp Lys Glu Thr Asn Glu Arg Lys Asp Ala Pro 435 440 445 Ile Lys Val Cys Ala Lys Ser Asn Pro Tyr Tyr Gin Glu Phe Arg Val 450 455 460 Leu Gin Trp Leu Gin Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg 465 470 475 480 Glu Val Thr Ala Glu Phe Ile Glu Thr Pro Gin Asp Cys Glu Ala Leu 485 490 495 Phe Asn Phe Leu Met Ser Gin Lys Glu Ile Asp Asn Lys Gly Leu Leu 500 505 510 Lys Tyr Phe Leu Phe Ala Lys Asn Pro Gin Ile Lys Asp Lys Ala Ala 515 520 525 Lys Ser Glu Leu Lys Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val 530 535 540 Tyr Asp Ala Ala Asp Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr 545 550 555 560 Page 1858 of 3790 Gly Tyr Glu Leu Gin Arg Tyr Leu Gin Lys Val Glu Gly Leu Pro Ala 565 570 575 Asn Phe Leu Thr Phe Asp Ile Thr Tyr Gin Leu Trp His Leu Leu Tyr 580 585 590 Ser Val Lys Asp Lys Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala 595 600 605 Lys Lys Lys Gin Leu Asp Lys Thr Ser Phe Val Asp Ser Phe Lys Asn 610 615 620 Phe Lys Pro Tyr Pro Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile 625 630 635 640 Lys Lys Leu Leu Pro Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn 645 650 655 Arg Ile Asp Val Ser Thr Gin Lys Arg Ile Asp Asp Leu Ile Asn Gly 660 665 670 Val Ala Asn Glu Asp Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys 675 680 685 Tyr Gin Leu Asn Ser Glu Thr Cys Phe Gin Asp Leu Pro Leu Trp Leu 690 695 700 Ala Gin Tyr Val Val Tyr Asn Arg His Ala Glu Ala Thr Asp Ile Glu 705 710 715 720 Lys Trp Thr Ser Val Ser Asp Leu Glu Ala Tyr Leu Glu Asp Phe Lys 725 730 735 Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin Val Val Thr Glu Thr 740 745 750 Leu Arg Val Val Arg Asp Ile Trp Gin Gin Tyr Gly Gly Gly Gin Ala 755 760 765 Asn Phe Phe Asp Glu Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys 770 775 780 Thr Ala Glu Glu Arg Lys Gin Leu Ser Asp Lys Asn Gin Glu Asn Glu 785 790 795 800 Ser Thr Asn Leu Arg Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp 805 810 815 Page 1859 of 3790 Met Asn Gin Leu Thr Gin Thr Gin Leu Phe Thr Ser Tyr Asn Asp 912 1450 PRT Capnocytophaga sp. 912 Met Lys His Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Ile Gly Trp 15 10 15 Ala Phe Val Gin Gin Asp Phe Glu Asn Lys Gin Gly Lys Ile Ile Ala 20 25 30 Page 1862 of 3790 Thr Gly Ser Arg Ile Ile Pro Met Asp Gin Gly Ile Leu Gly Asp Phe 35 40 45 Glu Arg Gly Asn Thr Val Ser Gin Thr Ala Glu Arg Thr Thr Tyr Arg 50 55 60 Asn Thr Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 His Arg Val Leu His Ile Leu Gly Phe Leu Pro Pro His Tyr Asp Ser 85 90 95 Gin Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe Ile Asp Asn Ala Glu 100 105 110 Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile Phe Met Asn Ser Phe 115 120 125 Asn Glu Met Ile Glu Asp Phe Lys Lys Tyr Gin Pro Gin Leu Phe Tyr 130 135 140 Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp Trp Thr Ile 145 150 155 160 Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Gin Lys Ile Thr Gin Gin Glu 165 170 175 Leu Ala Trp Leu Ile Leu His Phe Asn Gin Lys Arg Gly Tyr Tyr Gin 180 185 190 Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn Lys Glu Val Ala Phe 195 200 205 His Ser Leu Glu Val Val Asp Val Glu Ala Glu Ala Pro Asn Lys Lys 210 215 220 Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn Gly Trp Ile Tyr Arg 225 230 235 240 Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys Gly Lys Thr Arg Asp 245 250 255 Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly Thr Ile Lys Leu Asp 260 265 270 Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala Pro Asp Glu Asn Asp 275 280 285 Page 1863 of 3790 Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp Ile Asp Phe Ser Gly 290 295 300 Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu Leu Gin Asn Pro Asn 305 310 315 320 Gin Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 325 330 335 Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gin Ile Ala Leu Gin Pro 340 345 350 Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys Ile Arg Glu Leu Tyr 355 360 365 Arg Lys Asn Glu Thr Gin Gin Gin Asn Leu Leu Ser Lys Asp Phe Leu 370 375 380 His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gin Arg Pro Leu Arg Ser 385 390 395 400 Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu Lys Arg Ser Tyr Ile 405 410 415 Asp Lys Glu Thr Asn Glu Arg Lys Asp Thr Pro Ile Lys Val Cys Ala 420 425 430 Lys Ser Asn Pro Tyr Tyr Gin Glu Phe Arg Val Leu Gin Trp Leu Gin 435 440 445 Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg Glu Val Thr Ala Glu 450 455 460 Phe Ile Glu Thr Ala Gin Asp Asn Glu Ala Leu Phe Asn Phe Leu Met 465 470 475 480 Ser Gin Lys Glu Ile Asp Asn Glu Ser Leu Leu Lys Tyr Phe Leu Phe 485 490 495 Ala Lys Asn Pro Gin Ile Lys Asp Lys Val Ala Lys Ser Glu Leu Lys 500 505 510 Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Ala Asp 515 520 525 Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr Gly Tyr Glu Leu Gin 530 535 540 Page 1864 of 3790 Gin Tyr Leu Gin Lys Val Glu Gly Leu Pro Ala Asn Phe Leu Thr Phe 545 550 555 560 Asp Ile Thr Tyr Arg Leu Trp His Leu Leu Tyr Ser Val Lys Asp Lys 565 570 575 Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala Gin Glu Tyr Gin Leu 580 585 590 Asp Glu Ala Ser Phe Val Asp Ser Phe Lys Asn Phe Lys Pro Tyr Pro 595 600 605 Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro 610 615 620 Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn Arg Ile Asp Val Ser 625 630 635 640 Thr Gin Lys Arg Ile Asp Asp Leu Ile Asn Gly Val Ala Asn Asp Glu 645 650 655 Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys Tyr Gin Leu Asn Ser 660 665 670 Glu Thr Cys Phe Gin Gly Leu Pro Leu Trp Leu Ala Gin Tyr Val Val 675 680 685 Tyr Asn Arg His Ala Glu Ala Ala Asp Ile Glu Lys Trp Thr Ser Val 690 695 700 Asn Asp Leu Glu Ala Tyr Leu Glu Asp Phe Lys Gin His Ser Leu Arg 705 710 715 720 Asn Pro Ile Val Glu Gin Val Ile Thr Glu Thr Leu Arg Val Val Arg 725 730 735 Asp Ile Trp Gin Arg Tyr Gly Gly Gly Gin Ala Asn Phe Phe Asp Glu 740 745 750 Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys Thr Ala Glu Glu Arg 755 760 765 Lys Gin Leu Ser Asn Arg Asn Gin Glu Asn Glu Asn Thr Asn Leu Arg 770 775 780 Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp Ala Ser Ile Gin Asn 980 985 990 Asp Glu Gly Val Asn Ser Lys Asn Ile Ile Pro Cys Thr Gly Lys Ile 995 1000 1005 Thr Thr Ala Leu Lys Gin Asp Trp Gly Leu Asn Asp Val Trp Asn 1010 1015 1020 Glu Leu Ile Leu Pro Arg Phe Glu Arg Met Asn Gin Leu Thr Gin 1025 1030 1035 Page 1867 of 3790 1445 1450 913 1435 PRT Capnocytophaga sp. 913 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 15 10 15 Ala His Ile Val Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 20 25 30 Page 1868 of 3790 Leu Gly Val Arg Ile Val Ser Leu Ala Thr Asp Glu Gin Ser Asp Phe 35 40 45 Glu Lys Gly Lys Ser Ile Ser Thr Asn Ala Asn Arg Thr Leu Lys His 50 55 60 Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gin Gin Arg Arg Lys Phe Leu 65 70 75 80 Ile Asp Leu Leu Gin Lys Ala Asn Leu Ile Thr Ser Ala Ser Ile Leu 85 90 95 Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gin Leu Arg Ala 100 105 110 Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Val Leu 115 120 125 Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Asn Ser Arg Lys Thr Lys 130 135 140 Thr Glu Asp Glu Gly Gin Ala Ile Asp Gly Met Ala Ile Ala Lys Cys 145 150 155 160 Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gin Leu Ser Leu Gin Leu Leu 165 170 175 Gin Gin Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gin 180 185 190 Lys Glu Phe Asp Leu Val Trp Asn Leu Gin Lys Gin Phe Tyr Pro Asp 195 200 205 Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gin Gly Lys Gly Lys Asp 210 215 220 Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 225 230 235 240 Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gin Ala Tyr Gin Trp Arg 245 250 255 Ala Glu Ala Ile Ser Lys Gin Leu Ser Lys Glu Glu Val Ala Tyr Val 260 265 270 Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ser Ser Gly Tyr Leu Gly 275 280 285 Page 1869 of 3790 Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gin Thr Val 290 295 300 Gly Gin Tyr Leu Tyr Ala Gin Leu Gin Glu Asn Arg His Asn Ser Leu 305 310 315 320 Lys Asn Lys Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu Arg 325 330 335 Ile Trp Glu Thr Gin Ala Ser Phe His Lys Glu Leu Thr Asp Glu Leu 340 345 350 Lys Lys Gin Ile Arg Asp Val Val Ile Phe Tyr Gin Arg Lys Leu Lys 355 360 365 Ser Gin Lys Gly Leu Val Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 370 375 380 Glu Ile Glu Lys Asp Gly Lys Ala Ile Thr Lys Ser Ile Gly Ala Arg 385 390 395 400 Val Val Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys Ile Trp Gin 405 410 415 Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 420 425 430 Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gin 435 440 445 Ser Ile Phe Ser Leu Asp Met Glu Cys Lys Gin Leu Leu Phe Asp Glu 450 455 460 Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 465 470 475 480 Gly Tyr Ser Pro Gin Glu Trp Glu Ile Asn Tyr Asn Gin Leu Glu Gly 485 490 495 Asn Arg Thr Gin Lys Ser Leu Tyr Glu Ala Tyr Leu Lys Ile Ile Glu 500 505 510 Ile Glu Gly Tyr Glu Val Lys Asp Ile Leu Gin Ile Lys Ser Thr Lys 515 520 525 Asp Asp Trp Ser Leu Asp Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg Page 1871 of 3790 Asn Tyr Ser Val Ile Leu Ala Ile Glu Lys Lys Glu Thr Ile Lys 1010 1015 1020 Val Pro Ile Asn Asn Gly Lys Asn Lys Arg Val Phe Ile Glu Pro 1025 1030 1035 Page 1872 of 3790 Page 1873 of 3790 914 1432 PRT Capnocytophaga sp. 914 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 15 10 15 Ala His Ile Val 20 Glu Asp Glu Asn Lys Glu Lys Ser Glu Ile Lys Glu 30 Leu Gly Val Arg Ile Val Ser Leu Thr Thr Asp Glu Gin Ser Asp Phe 35 40 45 Page 1874 of 3790 Glu Lys Gly Lys Ser Ile Thr Thr Asn Ala Asn Arg Thr Leu Lys His 50 55 60 Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gin Gin Arg Arg Lys Tyr Leu 65 70 75 80 Ile Asp Leu Leu His Lys Ala Asn Leu Ile Thr Pro Ser Ser Ile Leu 85 90 95 Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gin Leu Arg Ala 100 105 110 Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Ile Leu 115 120 125 Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 130 135 140 Thr Glu Asp Glu Gly Gin Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 145 150 155 160 Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gin Leu Ser Leu Gin Leu Leu 165 170 175 Gin Gin Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gin 180 185 190 Lys Glu Phe Asp Leu Val Trp Asn Phe Gin Lys Gin Phe Tyr Pro Asp 195 200 205 Ile Leu Thr Asp Ile Phe Tyr Lys Glu Leu Gin Gly Lys Gly Lys Asp 210 215 220 Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 225 230 235 240 Asn Lys Gly Ser Lys Glu Ser Val Arg Leu Gin Ala Tyr Gin Trp Arg 245 250 255 Ala Glu Ala Val Ser Lys Gin Leu Ser Lys Glu Glu Val Ala Tyr Val 260 265 270 Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 275 280 285 Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gin Thr Val Page 1876 of 3790 Glu Ser Val Lys Ala Ile Phe Gin Ala Leu Gly Ile Cys Thr Lys Ile 545 550 555 560 Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Asp Phe Glu Glu Gin Asp 565 570 575 Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 580 585 590 Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 595 600 605 Phe Lys Arg Glu His Ala Arg Ile Leu Ala Asn Val Ala Leu Gin Asp 610 615 620 Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Asn 625 630 635 640 Ile Lys Glu Asn Gin Tyr Ser Thr Ala Cys Glu Met Ala Gly Tyr Lys 645 650 655 His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 660 665 670 Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 675 680 685 Val Glu Lys Ile Leu Asn Gin Met Ile Asn Val Val Asn Ala Leu Ile 690 695 700 Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 705 710 715 720 His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 725 730 735 Ala Gin Lys Arg Tyr Glu Met Thr Gin Asn Ile Asn Lys Ala Lys Ser 740 745 750 Glu His Gin Lys Ile Ser Glu Ile Leu Gin Lys Glu Phe Gly Ile Lys 755 760 765 Asn Pro Thr Lys Ser Asp Ile Ile Arg Tyr Arg Leu Tyr Lys Glu Leu 770 775 780 Glu His Asn Gly Tyr Lys Glu Leu Tyr Thr Asn Thr Tyr Ile Ala Pro 785 790 795 800 Page 1877 of 3790 Page 1878 of 3790 Val Asp Tyr Val Ser Thr Gly Asn Asn His His Val Ala Ile Tyr Ile Gly Glu Tyr 1430 915 1426 PRT Capnocytophaga sp. 915 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Thr Ser Ile Gly Phe 15 10 15 Thr His Ile Val 20 Glu Asp Glu Asn Lys 25 Glu Lys Ser Glu Ile Lys 30 Glu Leu Gly Val Arg 35 Ile Val Ser Leu Thr 40 Thr Asp Glu Gin Ser Asp Phe Glu Lys Gly Lys Ser Ile Ser Thr Asn Ala Asn Arg Thr Leu Lys His Page 1880 of 3790 55 60 Gly Ala Arg Leu Asn Leu Asp Arg Tyr Gin Gin Arg Arg Lys Phe Leu 65 70 75 80 Ile Asp Leu Leu Gin Lys Ala Asn Leu Ile Thr Ser Ser Ser Ile Leu 85 90 95 Ala Glu Asn Gly Lys Asn Thr Thr His Ser Thr Trp Gin Leu Arg Ala 100 105 110 Lys Ala Val Thr Glu Arg Ile Glu Lys Glu Glu Phe Ala Arg Val Leu 115 120 125 Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Lys 130 135 140 Thr Glu Asp Glu Gly Gin Ala Ile Asp Gly Met Ala Ile Ala Lys Arg 145 150 155 160 Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gin Leu Ser Leu Gin Leu Leu 165 170 175 Gin Gin Asn Lys Lys Leu Leu Pro Asp Phe Tyr Arg Ser Asp Leu Gin 180 185 190 Lys Glu Phe Asp Leu Val Trp Asn Phe Gin Lys Gin Phe Tyr Pro Asp 195 200 205 Ile Leu Thr Asp Ser Phe Tyr Lys Glu Leu Gin Gly Lys Gly Lys Asp 210 215 220 Ala Thr Ser Lys Ala Phe Ser Lys Arg Tyr His Phe Asp Thr Ala Glu 225 230 235 240 Asn Lys Gly Ser Arg Glu Ser Val Arg Leu Gin Ala Tyr Gin Trp Arg 245 250 255 Ala Glu Ala Ile Ser Lys Gin Leu Ser Lys Glu Glu Val Ala Tyr Val 260 265 270 Leu Thr Glu Ile Asn Asn Asn Leu Asn Asn Ala Ser Gly Tyr Leu Gly 275 280 285 Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Arg Gin Thr Val 290 295 300 Page 1881 of 3790 Gly Gin Tyr Leu Tyr Ala Gin Leu Gin Glu Asn Lys His Asn Ser Leu 305 310 315 320 Lys Asn Lys Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu Arg 325 330 335 Ile Trp Glu Thr Gin Ala Ser Phe His Lys Glu Leu Thr Glu Glu Leu 340 345 350 Lys Lys Gin Ile Arg Asp Val Val Ile Phe Tyr Gin Arg Lys Leu Lys 355 360 365 Ser Gin Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Ser Lys Glu Ile 370 375 380 Glu Ile Glu Lys Asp Gly Lys Thr Ile Thr Lys Ser Ile Gly Ala Arg 385 390 395 400 Val Val Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys Ile Trp Gin 405 410 415 Ile Leu Asn Asn Val Thr Cys Lys Arg Lys Gly Ile Arg Lys Lys Lys 420 425 430 Ser Ser Ala Lys Ser Thr Glu Leu Asp Leu Phe Asn Glu Pro Ser Gin 435 440 445 Thr Ile Phe Ser Leu Asp Met Glu Cys Lys Gin Leu Leu Phe Glu Glu 450 455 460 Leu Asn Leu Lys Gly Asp Leu Lys Ser Asp Lys Val Leu Lys Leu Leu 465 470 475 480 Gly Tyr Ser Pro Gin Glu Trp Glu Ile Asn Tyr Asn Gin Leu Glu Gly 485 490 495 Asn Arg Thr Gin Lys Ala Leu Tyr Glu Ala Tyr Leu Lys Ile Val Glu 500 505 510 Met Glu Ala His Asp Val Lys Asp Ile Leu Gin Ile Lys Ser Thr Lys 515 520 525 Asp Asp Trp Ala Leu Glu Glu Ser Pro Leu Ser Ala Ser Glu Ile Arg 530 535 540 Glu Arg Val Lys Ala Ile Phe Gin Thr Leu Gly Ile Cys Thr Lys Ile 545 550 555 560 Page 1882 of 3790 Leu Tyr Phe Asp Pro Leu Leu Pro Val Lys Glu Phe Glu Glu Gin Asp 565 570 575 Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asp Ser 580 585 590 Thr Ser Gly Asn Glu Thr Leu Tyr Arg Ile Leu Glu Lys Lys Tyr Ala 595 600 605 Phe Lys Arg Glu His Ala Thr Ile Leu Ala Asn Val Thr Leu Gin Asp 610 615 620 Asp Tyr Gly Ser Leu Ser Thr Lys Ala Ile Arg Lys Ile Tyr Pro Tyr 625 630 635 640 Ile Lys Glu Asn Gin Tyr Ser Thr Ala Cys Glu Lys Ala Gly Tyr Lys 645 650 655 His Ser Lys Leu Ser Leu Thr Thr Glu Glu Leu Glu Ala Arg Glu Leu 660 665 670 Lys Asn Ile Ile Pro Leu Leu Lys Lys Asn Ala Leu Arg Asn Pro Val 675 680 685 Val Glu Lys Ile Leu Asn Gin Met Ile Asn Val Val Asn Ala Leu Ile 690 695 700 Glu Lys Asn Ser Glu Arg Asp Ala Glu Gly Lys Ile Thr Lys Tyr Phe 705 710 715 720 His Phe Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Asn 725 730 735 Ala Gin Glu Arg Tyr Glu Met Thr Gin Asn Ile Asn Lys Ala Lys Leu 740 745 750 Glu His Gin Lys Ile Ser Gly Ile Leu Gin Lys Glu Phe Gly Ile Lys 755 760 765 Asn Pro Thr Lys Ser Asp Ile Thr Arg Tyr Arg Leu Tyr Gin Glu Leu 770 775 780 Ala His Asn Gly Tyr Asn Asp Leu Tyr Thr Asn Thr Tyr Ile Pro Lys 785 790 795 800 Glu Leu Leu Phe Ser Lys Asn Ile Asp Ile Glu His Ile Val Ser Lys 805 810 815 Page 1883 of 3790 Phe Ile Ser His Lys Ala Lys Asn Lys Val Val Thr Lys Asn Thr 916 1450 PRT Capnocytophaga sp. 916 Met Lys Arg Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Ile Gly Trp 15 10 15 Ala Phe Val Glu Gin Asp Phe Glu Asn Lys Gin Gly Lys Ile Ile Ala 20 25 30 Thr Gly Ser Arg 35 Ile Ile Pro Met Asp 40 Gin Gly Ile Leu Gly Asp Phe 45 Glu Lys 50 Gly Asn Thr Val Ser Gin Thr Ala 55 Glu Arg Thr 60 Thr Tyr Arg Ser Met Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 Page 1886 of 3790 His Arg Val Leu His Ile Leu Gly Phe Leu Pro Pro His Tyr Asp Ala 85 90 95 Gin Ile Asp Phe Thr Lys Arg Tyr Gly Lys Phe Ile Asp Asn Ala Glu 100 105 110 Pro Lys Ile Ala Tyr Asn Asn Gly Asn Phe Ile Phe Met Asn Ser Phe 115 120 125 Asn Glu Met Ile Glu Asp Phe Lys Lys Tyr Gin Pro Gin Leu Phe Tyr 130 135 140 Lys Lys Ser Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp Trp Thr Ile 145 150 155 160 Tyr Tyr Leu Arg Lys Lys Val Leu Ser Gin Lys Ile Thr Gin Gin Glu 165 170 175 Leu Ala Trp Leu Ile Leu His Phe Asn Gin Lys Arg Gly Tyr Tyr Gin 180 185 190 Leu Arg Gly Glu Glu Glu Thr Glu Asn Pro Asn Lys Glu Val Ala Phe 195 200 205 His Ser Leu Lys Val Val Asp Val Glu Ala Glu Ala Pro Asn Lys Lys 210 215 220 Gly Glu Ile Trp Tyr Thr Ile Arg Leu Glu Asn Gly Trp Ile Tyr Arg 225 230 235 240 Arg Thr Ser Lys Ile Pro Leu Asp Asp Trp Lys Gly Lys Thr Arg Asp 245 250 255 Phe Ile Val Thr Thr Asp Leu Asn Asp Asp Gly Thr Ile Lys Val Asp 260 265 270 Lys Glu Gly Lys Glu Lys Arg Ser Phe Arg Ala Pro Asp Glu Asn Asp 275 280 285 Trp Asn Leu Leu Lys Lys Lys Thr Glu His Asp Ile Asp Phe Ser Gly 290 295 300 Lys Thr Val Gly Ala Tyr Ile Tyr Asp His Leu Leu Gin Asn Pro Asn 305 310 315 320 Gin Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Tyr Tyr 325 330 335 Page 1887 of 3790 Lys Asp Glu Leu Lys Ala Ile Leu Ala Lys Gin Ile Ala Leu Gin Pro 340 345 350 Glu Leu Phe Thr Glu Thr Leu Leu Ala Asp Cys Ile Arg Glu Leu Tyr 355 360 365 Arg Lys Asn Glu Thr Gin Gin Gin Asn Leu Leu Ser Lys Asp Phe Leu 370 375 380 His Leu Phe Val Glu Asp Ile Ile Phe Tyr Gin Arg Pro Leu Arg Ser 385 390 395 400 Lys Lys Ser Thr Ile Ala Asn Cys Thr Leu Glu Lys Arg Ser Tyr Ile 405 410 415 Asp Lys Glu Thr Asn Glu Arg Lys Asp Thr Phe Ile Lys Val Cys Ala 420 425 430 Lys Ser Asn Pro Tyr Tyr Gin Glu Phe Arg Val Leu Gin Trp Leu Gin 435 440 445 Asn Leu Arg Ile Tyr Glu Ile Glu Thr Asp Arg Glu Val Thr Ala Glu 450 455 460 Phe Ile Glu Thr Ala Glu Asp Tyr Glu Ala Leu Phe Asn Phe Leu Met 465 470 475 480 Ser Gin Lys Glu Ile Asp Asn Glu Gly Leu Leu Lys Tyr Phe Leu Phe 485 490 495 Ala Lys Asn Pro Gin Ile Lys Asp Lys Val Ala Lys Ser Glu Leu Lys 500 505 510 Lys Trp Leu Thr Thr Tyr Arg Trp Asn Tyr Val Tyr Asp Ala Ala Asp 515 520 525 Asn Ser Ser Lys Lys Tyr Pro Met Asn Glu Thr Gly Tyr Asp Leu Gin 530 535 540 Arg Tyr Leu Gin Lys Val Glu Gly Leu Pro Ala Asn Phe Leu Thr Phe 545 550 555 560 Asp Ile Thr Tyr Arg Leu Trp His Leu Leu Tyr Ser Val Lys Asp Lys 565 570 575 Val Glu Phe Glu Lys Ala Leu Lys Lys Phe Ala Gin Glu Tyr Gin Leu 580 585 590 Page 1888 of 3790 Asp Glu Ala Ser Phe Val Asp Ser Phe Lys Asn Phe Lys Pro Tyr Pro 595 600 605 Asn Glu Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro 610 615 620 Leu Met Arg Phe Gly Asn His Trp Asp Phe Asn Arg Ile Asp Val Ser 625 630 635 640 Thr Gin Lys Arg Ile Asp Asp Leu Ile Asn Gly Val Ala Asn Asp Glu 645 650 655 Ile Arg Thr Ile Ile Arg Glu Lys Ala Glu Lys Tyr Gin Leu Asn Ser 660 665 670 Glu Ser Cys Phe Gin Gly Leu Pro Leu Trp Leu Ala Gin Tyr Val Val 675 680 685 Tyr Asn Arg His Ala Glu Ala Thr Asp Ile Glu Lys Trp Thr Ser Val 690 695 700 Ser Asp Leu Glu Thr Tyr Leu Glu Asp Phe Lys Gin His Ser Leu Arg 705 710 715 720 Asn Pro Ile Val Glu Gin Val Val Thr Glu Thr Leu Arg Val Val Arg 725 730 735 Asp Ile Trp Gin Gin Tyr Gly Gly Gly Gin Ala Asn Phe Phe Asp Glu 740 745 750 Ile His Ile Glu Leu Gly Arg Glu Leu Lys Lys Thr Ala Glu Glu Arg 755 760 765 Lys Gin Leu Ser Asn Arg Asn Gin Glu Asn Glu Asn Thr Asn Leu Arg 770 775 780 Ile Lys Lys Leu Leu Ala Glu Leu Lys Glu Asp Ala Ser Ile Gin Asn 785 790 795 800 Val Arg Pro Tyr Ser Pro Val Gin Gin Glu Leu Leu Lys Ile Tyr Glu 805 810 815 Glu Gly Val Phe Ser Ser Thr Asp Gin Val Glu Glu Asp Ile Gin Lys 820 825 830 Ile Arg Lys Lys Ala Glu Pro Thr Thr Pro Glu Ile Gin Arg Tyr Lys Page 1889 of 3790 Page 1891 of 3790 917 Met Lys Tyr Ile Lys Tyr Ile Leu Gly Leu Asp Ile Gly Ser Asn Ser 15 10 15 Ile Gly Trp Ala Leu 20 Ile Gin Leu Asp Leu Leu Gin Lys 25 Thr Lys Arg 30 Ile Ile Ala 35 Thr Gly Ser Arg Ile 40 Ile Pro Met Asp Gin Lys Val Leu Ser Asp Phe Gly Lys Gly Ile Thr Ile 50 55 Ser Pro Thr Ala Gin Arg Thr 60 Ser Tyr Arg Asn Ala Arg His Cys Arg Glu Arg His Leu Leu Arg Arg 65 70 75 80 Page 1892 of 3790 Glu Arg Leu His Arg Val Leu His Ile Leu Gly Phe Leu Pro Thr His 85 90 95 Tyr Asp Lys Gin Ile Asp Phe Ser Lys Arg Tyr Gly Lys Phe Val Asp 100 105 110 Asn Thr Glu Pro Lys Ile Ala Tyr Asn Glu Arg Lys Phe Leu Phe Met 115 120 125 Asp Ser Phe Gin Glu Met Leu Ala Asp Phe Lys Ile His Gin Pro Asp 130 135 140 Leu Phe Tyr Thr Lys Lys Asn Gly Glu Glu Ser Lys Ile Pro Tyr Asp 145 150 155 160 Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Arg Lys Ile Ser 165 170 175 Lys Glu Glu Leu Ala Trp Ile Ile Leu Asn Phe Asn Gin Lys Arg Gly 180 185 190 Tyr Tyr Gin Leu Arg Glu Glu Glu Glu Glu Asn Lys Glu Asn Asp Phe 195 200 205 Glu Ile Ile Ser Ser Lys Ile Ile Ser Val Ile Lys Lys Asp Lys Asp 210 215 220 Lys Lys Tyr Asn Lys Tyr Trp Tyr Asp Ile Ile Leu Glu Asn Gly Leu 225 230 235 240 Val Tyr Gin Ala Ala Phe Tyr Asn Asp Phe Val Tyr Asn Trp Ile Asn 245 250 255 Gin Asp Arg Glu Phe Ile Ile Glu Arg Ile Ser Leu Lys Asn Gly Thr 260 265 270 Glu Lys Val Lys Leu Ser Tyr Leu Pro Thr Phe Asp Glu Ile Asp Lys 275 280 285 Met Asp Lys Lys Glu Gin Asp Lys Tyr Tyr Lys Lys Ile Lys Ile Lys 290 295 300 Thr Glu Asn Ser Ile Gly Asn Lys Thr Val Gly Cys Tyr Ile Tyr Asp 305 310 315 320 His Ile Leu Gin Asn Pro Asn Glu Lys Ile Lys Gly Lys Leu Val Arg 325 330 335 Page 1893 of 3790 Thr Ile Glu Arg Lys Tyr Tyr Lys Glu Glu Leu Lys Ala Ile Leu Glu 340 345 350 Lys Gin Val Ala Leu Gin Pro Glu Leu Phe Thr Asp Gin Leu Phe Ala 355 360 365 Asp Cys Ile Arg Glu Leu Tyr Ser Lys Asn Glu Ala Gin Gin Arg Asn 370 375 380 Leu Ala Ala Arg Asp Phe Val His Leu Phe Val Glu Asp Ile Ile Phe 385 390 395 400 Tyr Gin Arg Ser Leu Arg Arg Gin Lys Ser Thr Leu Ala Asn Cys Ser 405 410 415 Leu Glu Ser Arg Ser Tyr Ile Asp Lys Asp Ser His Thr Arg Lys Glu 420 425 430 Ala Pro Leu Lys Val Cys Pro Lys Ser Asn Pro Tyr Tyr Gin Glu Phe 435 440 445 Arg Val Leu Gin Trp Leu Gin Asn Leu Lys Ile Tyr Glu Ile Asp Thr 450 455 460 Asp Gin Glu Val Thr His Glu Phe Ile Lys Thr Leu Glu Asp Lys Gin 465 470 475 480 Gin Phe Phe Asp Phe Leu Met Asn Gin Lys Glu Ile Asp Cys Glu Glu 485 490 495 Leu Leu Lys Tyr Phe Leu Asn Gin Thr Tyr Pro Asn Ala Arg Glu Lys 500 505 510 Ala Leu Lys Ser Glu Leu Lys Lys Trp Lys Asp Thr Tyr Arg Trp Asn 515 520 525 Tyr Val Tyr Asp Ile Gly Glu Lys Ser Ser Lys Lys Tyr Pro Met Asn 530 535 540 Glu Thr Arg Tyr Glu Leu Lys Arg His Leu Glu Lys Val Ala Asn Leu 545 550 555 560 Pro Asp Asp Phe Leu Ser Ser Glu Val Glu Tyr Leu Leu Trp His Leu 565 570 575 Ile Tyr Ser Val Lys Asp Lys Val Ala Tyr Glu Lys Gly Leu Lys Thr 805 810 815 Leu Trp Leu Glu Gin Lys His Ile Ser Pro Tyr Thr Gly Gin Ile Ile 820 825 830 Page 1895 of 3790 Page 1896 of 3790 Page 1897 of 3790 918 1140 PRT Catellicoccus marimammalium 918 Met Lys Asn Met Thr Lys Val Asn Val Gly Leu Asp Val Gly Ile Ser 15 10 15 Ser Ala Gly Trp Ser Val Ile Asn Ala Glu Thr Asn Gin Ile Leu Glu 20 25 30 Ser Gly Val Arg Leu Phe Ser Gly Ser Asp Ala Asp Glu Asn Val Asn 35 40 45 Arg Arg Asn Gin Arg Gin Gly Arg Arg Leu Phe Arg Arg Arg Lys Leu 50 55 60 Arg Ile Gin Glu Ala Lys Lys Tyr Leu Glu Asn Val Phe Gin Leu Lys 65 70 75 80 Asp Ile Glu Pro Lys Asp Glu Trp Asn Pro Tyr Glu Ile Arg Val Arg 85 90 95 Page 1898 of 3790 Ala Leu Asn Glu Lys Val Ser Lys Glu Glu Leu Ser Ile Ala Leu Leu 100 105 110 Asn Ile Val Lys His Arg Gly Ile Ser Tyr Glu Leu Glu Asp Val Thr 115 120 125 Asp Glu Glu Gly Thr Asn Thr Gin Ser Phe Gin Ser Gly Leu Asp Tyr 130 135 140 Asn Arg Arg Leu Leu Lys Thr Lys Thr Val Gly Glu Ile Gin Tyr Asp 145 150 155 160 Arg Leu Gin Lys Tyr Gly Gin Val Arg Gly Gin Ile Gin Thr Glu Asp 165 170 175 Gly Leu Leu Ile Asn Ile Phe Pro Thr Lys Asn Tyr Val Glu Glu Val 180 185 190 Glu Arg Ile Leu Glu Thr Gin Lys Lys Tyr His Pro Glu Ile Asp Asp 195 200 205 Val Phe Ile Glu Lys Ile Ile Ser Phe Val Thr Arg Lys Arg Glu Tyr 210 215 220 Phe Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 225 230 235 240 Arg Glu Asn Gly Glu Thr Leu Asp Asn Leu Phe Glu Ile Leu Ile Gly 245 250 255 Lys Asp Lys Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Gly Ser Ser Tyr 260 265 270 Thr Ala Gin Ile Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Arg Ile 275 280 285 Pro Thr Thr Glu Asp His His Leu Thr Lys Ala Gin Lys Glu Glu Ile 290 295 300 Ile Thr Glu Leu Lys Asn Thr Ser Arg Leu Ser Gly Gly Met Leu Lys 305 310 315 320 Leu Ile Ser Lys Val Thr Lys Ala Pro Lys Glu Glu Ile Ser Gly Tyr 325 330 335 Arg Lys Asp Glu Lys Asp Lys Pro Asp Leu His Ser Leu Ala Tyr Tyr Page 1900 of 3790 Leu Gin Asn Lys Gly Gly Tyr Glu Val Asp His Ile Ile Pro Ile Ser 595 600 605 Ile Ser Phe Asp Asp Arg Leu Cys Asn Lys Val Leu Val Arg Gin Gin 610 615 620 Leu Asn Ser Gin Lys Ser Asn Gin Thr Pro Phe Glu Tyr Met Thr Thr 625 630 635 640 His Thr Asp Gly His Leu Ser Phe His Glu Leu Lys Glu Leu Val Gly 645 650 655 Lys Asn Lys Arg Phe Ser Lys Glu Lys Arg Glu Leu Leu Leu Ala Glu 660 665 670 Ile Tyr Ser Asn Asp Ile Glu Thr Arg Lys Arg Phe Ile Asn Arg Asn 675 680 685 Leu Val Asp Thr Ser Tyr Thr Ala Arg Ile Val Leu Asn Ala Leu Gin 690 695 700 Gin Tyr Lys Lys Glu Asn Gin Leu Ser Met Asn Val Ser Val Val Arg 705 710 715 720 Gly Ala Met Thr Asn Ile Leu Arg Lys Lys Val Lys Leu Asp Lys Thr 725 730 735 Arg Glu Thr Phe His His His Ala Ile Asp Ala Ser Leu Met Ala Val 740 745 750 Ile Pro Asn Ile Glu Phe Phe Lys Glu Arg Lys Glu Trp Leu Pro Lys 755 760 765 Ser Ala Asn Glu Glu Val Val Glu Val Glu Val Ser Glu Glu Glu Thr 770 775 780 Met Pro Glu Lys Glu Phe Lys Val Lys Met Arg Leu Pro Glu Ser Phe 785 790 795 800 Ile Gin Asp Val Gin Ile Leu Gin Arg Asn Ser Phe Ala Lys Glu Glu 805 810 815 Val Ser Gly Pro Gin Thr Arg Glu Arg Asn Leu Lys Ile Lys Phe Ser 820 825 830 His Gin Val Asp Gin Lys Met Asn Arg Lys Val Ala Asp Asp Thr Ile 835 840 845 Page 1901 of 3790 Glu Asn 1055 Gly Glu Ser Ile Val 1060 Val Arg Tyr Leu Ser Arg Ser Met 1065 Glu Lys Tyr Gin Phe Glu Asp Gly Glu Val Val Pro Val Tyr Gly Lys Cys Arg 1085 1090 1095 Page 1902 of 3790 919 1419 PRT Chryseobacterium sp. 919 Page 1903 of 3790 Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr Gin Leu Arg Gly 180 185 190 Glu Asp Phe Glu Glu Glu Lys Asp Arg Val Phe Val Arg Leu Lys Val 195 200 205 Asp Arg Val Val Asp Ser Gly Glu Asn Ile Lys Gly Lys Ile Leu Tyr 210 215 220 Asp Val Tyr Phe Glu Asn Gly Trp Lys Tyr Glu Lys Gin Ile Val Lys 225 230 235 240 Thr Glu Asp Trp Ile Gly Arg Thr Lys Glu Phe Ile Val Thr Glu Ser 245 250 255 Ile Leu Lys Asn Gly Asp Thr Lys Arg Thr Phe Lys Ala Val Asp Ser 260 265 270 Glu Lys Asp Trp Ile Ala Ile Lys Thr Lys Thr Glu Gin Glu Ile Asp 275 280 285 Lys Ser His Lys Thr Val Gly Ala Tyr Ile Tyr Glu Ala Leu Leu Gin 290 295 300 Asn Pro Lys Gin Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg 305 310 315 320 Lys Phe Tyr Arg Glu Glu Leu Lys Lys Ile Leu Glu Arg Gin Lys Glu 325 330 335 Phe His Pro Glu Leu Gin Ser Asp Asp Leu Tyr Asn Asp Cys Ile Arg 340 345 350 Glu Leu Tyr Arg Asn Asn Glu Ala His Gin Ile Thr Leu Ser Lys Lys 355 360 365 Asp Phe Val His Leu Leu Leu Asn Asp Leu Ile Phe Tyr Gin Arg Pro 370 375 380 Leu Arg Ser Gin Lys Ser Ser Val Ser Asn Cys Thr Leu Glu Phe Arg 385 390 395 400 Lys Tyr Lys Asp Glu Asn Gly Val Glu His Ala Gin Tyr Leu Lys Thr 405 410 415 Ile Pro Lys Ser Asn Pro Tyr Tyr Gin Glu Phe Arg Val Trp Gin Trp 645 650 655 Ser Met Ile Gly Lys Trp Asn Ser Ala Asp Asp Leu Glu Glu Phe Leu 660 665 670 Page 1905 of 3790 Lys Gly Phe Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin Val 675 680 685 Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile Trp Leu Lys Tyr Gly 690 695 700 Asn Gly Ala Lys Asp Phe Phe Ser Glu Ile His Ile Glu Leu Gly Arg 705 710 715 720 Glu Met Lys Gin Thr Lys Asp Glu Arg Val Asp Ala Thr Lys Arg Ile 725 730 735 Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys Ala Leu Leu Ala Glu 740 745 750 Met Met Asn Asp Asn Ser Val Glu Asn Ile Arg Pro Tyr Ser Pro Met 755 760 765 Gin Gin Glu Ile Leu Lys Ile Tyr Glu Asp Gly Ile Leu Lys Ser Asp 770 775 780 Ile Glu Ile Asp Asp Asp Ile Leu Lys Ile Ser Lys Thr Ala Gin Pro 785 790 795 800 Ser Ser Ser Asp Leu Lys Arg Tyr Lys Leu Trp Leu Glu Gin Arg Tyr 805 810 815 Lys Ser Pro Tyr Thr Gly Gin Ile Ile Pro Leu Asn Lys Leu Phe Thr 820 825 830 Ser Glu Tyr Glu Ile Glu His Ile Ile Pro Gin Ser Arg Tyr Phe Asp 835 840 845 Asp Ser Phe Ser Asn Lys Ile Ile Cys Glu Ser Ala Val Asn Lys Leu 850 855 860 Lys Asp Asn Tyr Ile Gly Leu Gly Phe Ile Lys Gin Phe Gly Gly Met 865 870 875 880 Ile Val Glu Cys Gly Phe Gly Lys Ser Val Glu Ile Phe Lys Ala Glu 885 890 895 Glu Tyr Glu Asp Phe Val Lys Lys His Tyr Ala Asn Asn Arg Ser Lys 900 905 910 Arg Asn Lys Leu Leu Leu Glu Glu Ile Pro Glu Lys Met Ile Asp Arg 915 920 925 Page 1906 of 3790 Page 1907 of 3790 Ser Met Ile Lys Glu Asn Cys Ile Lys Leu Lys Ile Asp Arg Leu Page 1908 of 3790 1400 1405 1410 Gly Asn Ile Ala Lys Ile 1415 920 1065 PRT Clostridium perfringens 920 Met Cys Val Ser Arg Asp Val Leu Arg Glu Glu Ile His Thr Leu Phe Page 1909 of 3790 195 200 205 Glu Lys Gin Arg Glu Leu Gly Asn Asn Phe Ala Ser Asp Glu Ile Glu 210 215 220 Asp Lys Tyr Phe Glu Ile Phe Asn Ser Gin Arg Pro Phe Ser Asn Phe 225 230 235 240 Glu Asp Leu Glu Lys Leu Val Gly Phe Cys Thr Phe Glu Arg Lys Lys 245 250 255 His Lys Arg Ala Pro Lys His Cys Ile Ser Ser Glu Glu Phe Thr Leu 260 265 270 Tyr Glu Gly Ile Asn Lys Leu Ser Ile Ile Lys Asp Gly Glu Lys Arg 275 280 285 Lys Leu Ser Glu Glu Glu Arg Thr Leu Val Val Asn Glu Ala Phe Asn 290 295 300 Lys Lys Glu Ile Lys Tyr Thr Thr Leu Arg Lys Leu Leu Gly Leu Ser 305 310 315 320 Glu Asp Glu Leu Phe Ser Thr Leu Thr Tyr Ser Ile Asp Lys Asp Ile 325 330 335 Ser Lys Thr Glu Asn Thr Lys Phe Val Ser Leu Lys Gly Tyr His Glu 340 345 350 Ile Lys Arg Ala Ile Glu Lys Gly Val Ser Lys Lys Ala Trp Gin Asp 355 360 365 Ile Glu Asn Asn Arg Asn Leu Leu Asn Asp Ile Ala Tyr Val Leu Thr 370 375 380 Leu Gly Lys Thr Asp Asp Glu Ile Glu Lys Gin Leu Arg Leu Arg Asn 385 390 395 400 Val Pro Glu Glu Leu Phe Glu Ser Leu Leu Asp Met Ser Phe Ser Lys 405 410 415 Phe Asn Asn Leu Ser Ile Tyr Ala Leu Glu Lys Ile Leu Pro Phe Met 420 425 430 Lys Glu Gly Tyr Gin Tyr Asn Glu Ala Cys Glu Lys Ala Gly Tyr Asn 435 440 445 Page 1910 of 3790 Phe Lys Ala Ile Tyr Glu Gly Val Arg Thr Lys Lys Leu Pro Val Ile 450 455 460 Glu Ile Asp Glu Ile Val Asn Pro Val Val Asn Arg Ala Leu Ala Gin 465 470 475 480 Thr Arg Lys Val Ile Asn Ser Val Ile Asp Lys Tyr Gly Ser Pro Val 485 490 495 Arg Ile Asn Ile Glu Leu Ala Arg Asp Leu Ala Lys Asn Phe Lys Asp 500 505 510 Arg Lys Leu Ile Glu Lys Glu Gin Lys Glu Asn Arg Ala Asn Leu Asp 515 520 525 Lys Ile Arg Glu Asn Leu Arg Glu Leu Met Asp Lys Glu Pro Thr Ala 530 535 540 Val Glu Val Leu Lys Tyr Arg Leu Trp Glu Gin Gin Arg Gly Glu Cys 545 550 555 560 Ala Tyr Thr Gin Ser Gin Ile Ala Leu Glu Arg Leu Phe Ser Pro Gly 565 570 575 Tyr Cys Glu Ile Asp His Ile Ile Pro Phe Ser Arg Ser Phe Asp Asp 580 585 590 Ser Leu Ser Asn Lys Ile Leu Val Leu Gly Ser Glu Asn Gin Arg Lys 595 600 605 Gly Asn Lys Ile Pro Tyr Glu Tyr Phe Gly Glu Asp Ser Glu Arg Trp 610 615 620 Asn Ser Phe Glu Ile Trp Val Lys Gly Ser Tyr Leu Asn Tyr Lys Lys 625 630 635 640 Lys Ala Asn Leu Leu Lys Lys Lys Phe Thr Glu Glu Glu Gin Arg Asp 645 650 655 Trp Lys Ala Arg Asn Leu Gin Asp Thr Lys Tyr Ile Cys Arg Tyr Ile 660 665 670 Ser Asn Phe Val Asn Asn Arg Leu Glu Phe Lys Glu Ser Glu Asn Lys 675 680 685 Gin Lys Val Ile Thr Val Asn Gly Arg Ala Thr Ala Tyr Leu Arg Ser 690 695 700 Page 1911 of 3790 Arg Trp Gly Leu Asn Lys Val Arg Glu Asp Gly Asp Lys His His Ala 705 710 715 720 Leu Asp Ala Ala Val Val Gly Val Thr Thr Gin Gly Met Val Gin Lys 725 730 735 Ile Ser Lys Tyr Ser Lys Ala His Glu Leu Tyr Thr Val Arg Lys Asn 740 745 750 Asp Glu Phe Val Asp Val Glu Thr Gly Glu Cys Val Asp Val Asp Glu 755 760 765 Tyr Lys Glu Ile Arg Lys Asp Ile Leu Pro Arg Pro Trp Arg Gly Phe 770 775 780 Ser Glu Glu Leu Lys Leu Arg Leu Ser Asp Asn Pro Leu Glu Glu Leu 785 790 795 800 Lys Lys Leu Pro Ile Glu Thr Tyr Asn Glu Glu Phe Ile Lys Glu Asn 805 810 815 Val Lys Pro Ile Phe Val Ser Arg Val Pro Phe Arg Lys Ile Ser Gly 820 825 830 Lys Leu Phe Lys Glu Thr Ile Tyr Ser Glu Arg Ala Phe Lys Asp Gly 835 840 845 Tyr Phe Val Ser Lys Lys Ser Leu Val Asp Leu Lys Arg Gly Asp Leu 850 855 860 Asp Asn Phe Tyr Asn Tyr Glu Cys Asp Lys Lys Leu Tyr Asp Ala Ile 865 870 875 880 Ser Glu Arg Met Lys Glu Phe Asn Tyr Asn Gly Lys Lys Ala Phe Glu 885 890 895 Ser Pro Phe Arg Lys Pro Thr Lys Ser Gly Lys Glu Gly Pro Val Val 900 905 910 Arg Ser Val Lys Ile Lys Ser Ala Ala Pro Phe Lys Asp Gly Ile Pro 915 920 925 Met Asn Glu Gly Leu Val Ala Lys Glu Gly Met Val Arg Ile Asp Ile 930 935 940 Tyr Glu Lys Glu Gly Lys Tyr Phe Val Val Pro Val Tyr Arg Tyr Gin 945 950 955 960 Page 1912 of 3790 921 1099 PRT Corynebacterium accolens 921 Met Ser Leu Ser Tyr Arg Val Gly Ile Asp Val Gly Thr Tyr Ser Leu 15 10 15 Gly Cys Thr Ala Ile Glu Val Asp Asp Asn Asp Gin Pro Val Asn Ile 20 25 30 Leu Ser Ser Val Ser Leu Ile His Asp Ser Gly Leu Asp Pro Asp Gin 35 40 45 Gin Lys Arg Ala Val Thr Arg Leu Ala Ser Ser Gly Val Ala Arg Arg 50 55 60 Thr Arg Arg Leu Tyr Arg Arg Arg Arg Arg Arg Met Ile Asn Leu Glu 65 70 75 80 Lys Phe Leu Thr Ser Gin Gly Trp Glu Thr Arg Pro Phe Glu His Tyr 85 90 95 Ser Asp Pro Tyr Leu Pro Trp Asn Ala Arg Val Ala Leu Val Asn Gly 100 105 110 Page 1913 of 3790 Tyr Ile Ser Asp Asp Ala Gin Arg Gly Met Tyr Leu Ser Ile Ala Phe 115 120 125 Arg His Ile Ala Asn His Arg Gly Trp Arg Asn Pro Tyr Trp Lys Val 130 135 140 Ser Ser Leu Tyr Ser Pro Asp Lys Pro Ser Asp Ala Phe Glu Gin Ile 145 150 155 160 Arg Lys Glu Leu Glu Glu Ser Thr Gly His Lys Ile Pro Glu Thr Val 165 170 175 Thr Val Gly Gin Leu Ile Ser Phe Ala Gin Phe Gly Lys Asp Arg Leu 180 185 190 Arg Gly Gly Gly Lys Lys Lys Asp Glu Lys Lys Pro Gin Glu Gin Val 195 200 205 Asn Gin Ala Val Ile Ser Ala Arg Leu His Gin Ile Asp His Ala Arg 210 215 220 Glu Ile Asn Glu Ile Cys Arg Val Gin Lys Ile Asp Asp Ala Leu Arg 225 230 235 240 Lys Gin Ile Leu Asp Leu Val Phe Ala Ala Glu Ser Pro Lys Gly Ala 245 250 255 Gin Ile Gly Arg Val Gly Lys Asp Pro Leu Gin Pro Lys Leu Pro Arg 260 265 270 Ala Leu Lys Ala Ser Asp Ala Phe Gin Gin Tyr Arg Ile Val Ala Leu 275 280 285 Ala Gly Asn Leu Arg Ile Tyr Arg Asp Gly Val Ser Thr Pro Leu Asp 290 295 300 Arg Asp Glu Lys Leu Ile Val Phe Asn Tyr Leu Ile Asn Leu Ser His 305 310 315 320 Lys Glu Glu Pro Ser Trp Leu Lys Val Ala Glu Val Leu Asn Ile Asp 325 330 335 Arg Gly Gin Leu His Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 340 345 350 Ala Gly Ala Ala Pro Pro Val His Asp Thr Asn Arg Thr Ile Leu Gly Page 1914 of 3790 355 360 365 Cys Lys Ile Lys Pro Leu Val His Trp Trp Glu Gly Ala Asn Asp Asp 370 375 380 Glu Arg Ala Ala Met Leu Lys Ala Leu Ser Asn Ser Glu Val Glu Asp 385 390 395 400 Phe Asp Ser Pro Ala Gly Ala Gin Thr Gin Ala Phe Phe Ala Asn Leu 405 410 415 Asp Glu Ser Glu Gin Glu Lys Leu Asp Ser Leu His Leu Pro Ile Gly 420 425 430 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Met Arg Leu Thr Ser Arg Met 435 440 445 Leu Asp Glu Asn Leu Asp Leu Tyr Glu Ala Arg Leu Ala Glu Phe Asp 450 455 460 Ile Pro Lys Asp Trp Ala Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 465 470 475 480 Gly Asn Pro Ala Val Asp Arg Val Leu Lys Gly Val Ala Arg Trp Leu 485 490 495 Glu Ala Ala Ala Asp Glu Trp Gly Ala Pro Lys Ser Val Val Ile Glu 500 505 510 His Val Arg Asp Gly Phe Ile Ser Lys Ser Lys Ala Asn Glu Ile Asp 515 520 525 Arg Ala Asn Asn Ala Arg His Lys Arg Asn Arg Glu Leu Phe Lys Gin 530 535 540 Met Gin Glu Asn Leu Gly Ile Asp Gly Lys Leu Arg Ser Ser Asp Leu 545 550 555 560 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 565 570 575 Gly Ser Pro Ile Thr Tyr Thr Thr Cys Glu Met Asp His Ile Val Pro 580 585 590 Arg Ala Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala Thr 595 600 605 Page 1915 of 3790 Cys His Arg Cys Asn Leu Ala Lys Lys Asn Ile Pro Phe Ala Val Trp 610 615 620 Ala Ala Gin Thr Asn Ile Pro Gly Val Ser Val Lys Glu Ala Leu Asp 625 630 635 640 Arg Thr Arg His Trp Ser Glu Asp Ser Gly Met Thr Ser Lys Asp Phe 645 650 655 Lys Lys Phe Arg Lys Asn Val Cys Asp Arg Leu Lys Arg Thr Val Val 660 665 670 Asp Glu Pro Leu Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 675 680 685 Asn Glu Leu Arg Gly Arg Val Ala Gin Arg Phe Gin Glu Glu Asn Thr 690 695 700 Val Val Asn Val Tyr Arg Gly Glu Leu Thr Ala Glu Ala Arg Arg Ala 705 710 715 720 Ala Gly Ile Ser Asp Lys Leu Arg Phe Ile Asp Gly Thr Gly Lys Ser 725 730 735 Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala Phe 740 745 750 Thr Gin Asn Tyr Val Ala Glu Thr Leu Ala Ile Arg Ser Asn Lys Lys 755 760 765 Arg Glu Ala Gin Leu Leu Gin Ala Ala Glu Gin Trp Lys Glu Phe Thr 770 775 780 Gly Ser Asp Ala Glu His Arg Ala Ala Trp Asn Ala Trp Leu Pro Lys 785 790 795 800 Met Gin Lys Leu Ala Val Leu Leu Gin Lys Ala Leu Asp Glu Asp Arg 805 810 815 Ile Ala Val Thr Ser Asn Leu Arg Leu Arg Leu Gly Asn Gly Arg Ala 820 825 830 His Glu Asp Ser Ile Gly Glu Leu Lys Thr Ile Arg Val Gly Asp Ala 835 840 845 Ile Ser Val Thr Asp Ile Asp Arg Ala Ser Ser Glu Ala Leu Trp Cys 850 855 860 Page 1916 of 3790 Glu Page 1917 of 3790 922 1084 PRT Corynebacterium diphtheriae 922 Page 1918 of 3790 Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 225 230 235 240 Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gin Pro Gly Lys Asn Arg 245 250 255 Ala Leu Lys Ala Ser Asp Ala Phe Gin Arg Tyr Arg Ile Ala Ala Leu 260 265 270 Ile Gly Asn Leu Arg Val Trp Val Asp Gly Glu Lys Arg Ile Leu Ser 275 280 285 Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Thr Pro 290 295 300 Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 305 310 315 320 Arg Gly Gin Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 325 330 335 Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 340 345 350 Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 355 360 365 Glu Gin His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 370 375 380 Phe Asp Ser Pro Glu Arg Ala Lys Val Gin Ala Phe Phe Ala Asp Leu 385 390 395 400 Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 405 410 415 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 420 425 430 Leu Ser Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gin Glu Phe Gly 435 440 445 Ile Glu Pro Ser Trp Thr Pro Pro Thr Pro Arg Ile Gly Glu Pro Val 450 455 460 Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu Page 1920 of 3790 Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 725 730 735 Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 740 745 750 Gin Ser Gin Ala His Arg Gin Glu Ala Pro Gin Trp Arg Glu Phe Thr 755 760 765 Gly Lys Asp Ala Glu His Arg Ala Thr Trp Arg Val Trp Cys Gin Lys 770 775 780 Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 785 790 795 800 Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 805 810 815 His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gin 820 825 830 Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 835 840 845 Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 850 855 860 Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 865 870 875 880 Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 885 890 895 Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 900 905 910 Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 915 920 925 Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gin Asp Leu Phe Ser Val Glu 930 935 940 Leu Lys Pro Gin Thr Met Ser Met Arg Gin Ala Glu Lys Lys Leu Arg 945 950 955 960 Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 965 970 975 Page 1921 of 3790 Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gin Val 980 985 990 Lys Ala Val Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 995 1000 1005 Gin 923 1084 PRT Corynebacterium diphtheriae 923 Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 15 10 15 Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 20 25 30 Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Glu Ile Lys 35 40 45 Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 50 55 60 Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gin Gin Leu Asp Lys Phe 65 70 75 80 Ile Gin Arg Gin Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 85 90 95 Page 1922 of 3790 Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 100 105 110 Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 115 120 125 Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 130 135 140 Leu Tyr Leu Pro Asp Gly Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 145 150 155 160 Glu Ile Lys Arg Ala Ser Gly Gin Pro Val Pro Glu Thr Ala Thr Val 165 170 175 Gly Gin Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 180 185 190 Glu Gly Gly Val Leu Ser Ala Arg Leu Gin Gin Ser Asp His Ala Arg 195 200 205 Glu Ile Gin Glu Ile Cys Arg Met Gin Glu Ile Gly Gin Glu Leu Tyr 210 215 220 Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 225 230 235 240 Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gin Pro Gly Lys Asn Arg 245 250 255 Ala Leu Lys Ala Ser Asp Ala Phe Gin Arg Tyr Arg Ile Ala Ala Leu 260 265 270 Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 275 280 285 Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 290 295 300 Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 305 310 315 320 Arg Gly Gin Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 325 330 335 Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 340 345 350 Page 1923 of 3790 Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 355 360 365 Glu Gin His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 370 375 380 Phe Asp Ser Pro Glu Gly Ala Lys Val Gin Ala Phe Phe Ala Asp Leu 385 390 395 400 Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 405 410 415 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 420 425 430 Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gin Glu Phe Gly 435 440 445 Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 450 455 460 Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 465 470 475 480 Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 485 490 495 His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 500 505 510 Gly Asp Met Gin Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gin Glu 515 520 525 Met Gin Glu Lys Leu Asn Val Gin Gly Lys Pro Ser Arg Ala Asp Leu 530 535 540 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 545 550 555 560 Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 565 570 575 Arg Ala Gly Gin Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 580 585 590 Cys His Arg Cys Asn Gin Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp Page 1924 of 3790 595 600 605 Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 610 615 620 Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Pro Asp Phe 625 630 635 640 Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gin Arg Ala Thr Met 645 650 655 Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 660 665 670 Asn Glu Leu Arg Ser Arg Val Ala Gin His Phe Ala Ser His Gly Thr 675 680 685 Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 690 695 700 Ser Gly Ile Ser Gly Lys Leu Lys Phe Phe Asp Gly Val Gly Lys Ser 705 710 715 720 Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 725 730 735 Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 740 745 750 Gin Ser Gin Ala His Arg Gin Glu Ala Pro Gin Trp Arg Glu Phe Thr 755 760 765 Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gin Lys 770 775 780 Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 785 790 795 800 Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 805 810 815 His Lys Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gin 820 825 830 Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 835 840 845 Page 1925 of 3790 Lys Ala Val 995 Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 1000 1005 Gly Phe Phe 1010 Ser Pro Ser Lys 1015 Leu Arg Leu Arg Pro 1020 Leu Gin Met Ser Lys 1025 Glu Gly Ile Lys Lys 1030 Glu Ser Ala Pro Glu 1035 Leu Ser Lys Ile Ile Asp Arg Pro Gly 1040 Trp 1045 Leu Pro Ala Val Asn 1050 Lys Leu Phe Ser Asp 1055 Gly Asn Val Thr Val 1060 Val Arg Arg Asp Ser 1065 Leu Gly Arg Val Arg 1070 Leu Glu Ser Thr Ala 1075 His Leu Pro Val Thr 1080 Trp Lys Val Gin Page 1926 of 3790 924 1084 PRT Corynebacterium diphtheriae 924 Page 1927 of 3790 Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 225 230 235 240 Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gin Pro Gly Lys Asn Arg 245 250 255 Ala Leu Lys Ala Ser Asp Ala Phe Gin Arg Tyr Arg Ile Ala Ala Leu 260 265 270 Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 275 280 285 Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 290 295 300 Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 305 310 315 320 Arg Gly Gin Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 325 330 335 Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 340 345 350 Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 355 360 365 Glu Gin His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 370 375 380 Phe Asp Ser Pro Glu Gly Ala Lys Val Gin Ala Phe Phe Ala Asp Leu 385 390 395 400 Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 405 410 415 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 420 425 430 Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gin Glu Phe Gly 435 440 445 Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 450 455 460 Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 465 470 475 480 Page 1928 of 3790 Lys Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 485 490 495 His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 500 505 510 Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gin Glu 515 520 525 Met Gin Glu Lys Leu Asn Val Gin Gly Lys Pro Ser Arg Ala Asp Leu 530 535 540 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 545 550 555 560 Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 565 570 575 Arg Ala Gly Gin Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 580 585 590 Cys His Arg Cys Asn Gin Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 595 600 605 Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 610 615 620 Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 625 630 635 640 Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gin Arg Ala Thr Met 645 650 655 Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 660 665 670 Asn Glu Leu Arg Ser Arg Val Ala Gin His Phe Ala Ser His Gly Thr 675 680 685 Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 690 695 700 Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 705 710 715 720 Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe Page 1930 of 3790 Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gin Val 980 985 990 Lys Ala Val Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 995 1000 1005 Gin 925 1084 PRT Corynebacterium diphtheriae 925 Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 15 10 15 Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 20 25 30 Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Ile Lys 35 40 45 Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 50 55 60 Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gin Gin Leu Asp Lys Phe 65 70 75 80 Ile Gin Arg Gin Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 85 90 95 Page 1931 of 3790 Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile 100 105 110 Ala Asp Glu Lys Glu Arg Gly Glu Lys Leu Ser Val Ala Leu Arg His 115 120 125 Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ala Lys Val Ser Ser 130 135 140 Leu Tyr Leu Pro Asp Glu Pro Ser Asp Ala Phe Lys Ala Ile Arg Glu 145 150 155 160 Glu Ile Lys Arg Ala Ser Gly Gin Pro Val Pro Glu Thr Ala Thr Val 165 170 175 Gly Gin Met Val Thr Leu Cys Glu Leu Gly Thr Leu Lys Leu Arg Gly 180 185 190 Glu Gly Gly Val Leu Ser Ala Arg Leu Gin Gin Ser Asp His Ala Arg 195 200 205 Glu Ile Gin Glu Ile Cys Arg Met Gin Glu Ile Gly Gin Glu Leu Tyr 210 215 220 Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 225 230 235 240 Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gin Pro Gly Lys Asn Arg 245 250 255 Ala Leu Lys Ala Ser Asp Ala Phe Gin Arg Tyr Arg Ile Ala Ala Leu 260 265 270 Ile Gly Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 275 280 285 Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 290 295 300 Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 305 310 315 320 Arg Gly Gin Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 325 330 335 Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 340 345 350 Page 1932 of 3790 Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 355 360 365 Glu Gin His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 370 375 380 Phe Asp Ser Pro Glu Gly Ala Lys Val Gin Ala Phe Phe Ala Asp Leu 385 390 395 400 Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 405 410 415 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 420 425 430 Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gin Glu Phe Gly 435 440 445 Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 450 455 460 Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 465 470 475 480 Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 485 490 495 His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 500 505 510 Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gin Glu 515 520 525 Met Gin Glu Lys Leu Asn Val Gin Gly Lys Pro Ser Arg Ala Asp Leu 530 535 540 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 545 550 555 560 Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 565 570 575 Arg Ala Gly Gin Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 580 585 590 Cys His Arg Cys Asn Gin Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 595 600 605 Page 1933 of 3790 Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 610 615 620 Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 625 630 635 640 Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gin Arg Ala Thr Met 645 650 655 Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 660 665 670 Asn Glu Leu Arg Ser Arg Val Ala Gin His Phe Ala Ser His Gly Thr 675 680 685 Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 690 695 700 Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 705 710 715 720 Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 725 730 735 Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 740 745 750 Gin Ser Gin Ala His Arg Gin Glu Ala Pro Gin Trp Arg Glu Phe Thr 755 760 765 Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gin Lys 770 775 780 Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 785 790 795 800 Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 805 810 815 His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gin 820 825 830 Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 835 840 845 Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 850 855 Page 1934 of 3790 860 Lys Ala Val 995 Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 1000 1005 Gly Phe 1010 Phe Gly Asp Thr Arg 1015 Leu Arg Leu Arg Pro 1020 Leu Gin Met Ser Lys 1025 Glu Gly Ile Lys Lys 1030 Glu Ser Ala Pro Glu 1035 Leu Ser Lys Ile Ile Asp Arg Pro Gly 1040 Trp 1045 Leu Pro Ala Val Asn 1050 Lys Leu Phe Ser Glu 1055 Gly Asn Val Thr Val 1060 Val Arg Arg Asp Ser 1065 Leu Gly Arg Val Arg 1070 Leu Glu Ser Thr Ala 1075 His Leu Pro Val Thr 1080 Trp Lys Val Gin Page 1935 of 3790 926 1084 PRT Corynebacterium diphtheriae 926 Page 1936 of 3790 Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser 225 230 235 240 Ala Ser Ser Arg Val Gly Lys Asp Pro Leu Gin Pro Gly Lys Asn Arg 245 250 255 Ala Leu Lys Ala Ser Asp Ser Phe Gin Arg Tyr Arg Ile Ala Ala Leu 260 265 270 Ile Ser Asn Leu Arg Val Arg Val Asp Gly Glu Lys Arg Ile Leu Ser 275 280 285 Val Glu Glu Lys Asn Leu Val Phe Asp His Leu Val Asn Leu Ala Pro 290 295 300 Lys Lys Glu Pro Glu Trp Val Thr Ile Ala Glu Ile Leu Gly Ile Asp 305 310 315 320 Arg Gly Gin Leu Ile Gly Thr Ala Thr Met Thr Asp Asp Gly Glu Arg 325 330 335 Ala Gly Ala Arg Pro Pro Thr His Asp Thr Asn Arg Ser Ile Val Asn 340 345 350 Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 355 360 365 Glu Gin His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 370 375 380 Phe Asp Ser Pro Glu Gly Ala Lys Val Gin Ala Phe Phe Ala Asp Leu 385 390 395 400 Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 405 410 415 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 420 425 430 Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gin Glu Phe Gly 435 440 445 Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 450 455 460 Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 465 470 475 480 Page 1937 of 3790 Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 485 490 495 His Val Arg Asp Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 500 505 510 Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gin Glu 515 520 525 Met Gin Glu Lys Leu Asn Val Gin Gly Lys Pro Ser Arg Ala Asp Leu 530 535 540 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 545 550 555 560 Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 565 570 575 Arg Ala Gly Gin Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 580 585 590 Cys His Arg Cys Asn Gin Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 595 600 605 Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 610 615 620 Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 625 630 635 640 Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gin Arg Ala Thr Met 645 650 655 Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 660 665 670 Asn Glu Leu Arg Ser Arg Val Ala Gin His Phe Ala Ser His Gly Thr 675 680 685 Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 690 695 700 Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 705 710 715 720 Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 725 730 735 Page 1938 of 3790 Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 740 745 750 Gin Ser Gin Ala His Arg Gin Glu Ala Pro Gin Trp Arg Glu Phe Thr 755 760 765 Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gin Lys 770 775 780 Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 785 790 795 800 Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 805 810 815 His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gin 820 825 830 Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 835 840 845 Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 850 855 860 Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 865 870 875 880 Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 885 890 895 Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 900 905 910 Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 915 920 925 Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gin Asp Leu Phe Ser Val Glu 930 935 940 Leu Lys Pro Gin Thr Met Ser Met Arg Gin Ala Glu Lys Lys Leu Arg 945 950 955 960 Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 965 970 975 Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gin Val 980 990 Page 1939 of 3790 985 Lys Ala Val Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 995 1000 1005 Gin 927 1084 PRT Corynebacterium diphtheriae 927 Met Lys Tyr His Val Gly Ile Asp Val Gly Thr Phe Ser Val Gly Leu 15 10 15 Ala Ala Ile Glu Val Asp Asp Ala Gly Met Pro Ile Lys Thr Leu Ser 20 25 30 Leu Val Ser His Ile His Asp Ser Gly Leu Asp Pro Asp Lys Met Lys 35 40 45 Ser Ala Val Thr Arg Leu Ala Ser Ser Gly Ile Ala Arg Arg Thr Arg 50 55 60 Arg Leu Tyr Arg Arg Lys Arg Arg Arg Leu Gin Gin Leu Asp Lys Phe 65 70 75 80 Ile Gin Arg Gin Gly Trp Pro Val Ile Glu Leu Glu Asp Tyr Ser Asp 85 90 95 Pro Leu Tyr Pro Trp Lys Val Arg Ala Glu Leu Ala Ala Ser Tyr Ile Page 1941 of 3790 Ser Arg Ile Ala Pro Leu Val Asp Trp Trp Lys Thr Ala Ser Ala Leu 355 360 365 Glu Gin His Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Asp 370 375 380 Phe Asp Ser Pro Glu Gly Ala Lys Val Gin Ala Phe Phe Ala Asp Leu 385 390 395 400 Asp Asp Asp Val His Ala Lys Leu Asp Ser Leu His Leu Pro Val Gly 405 410 415 Arg Ala Ala Tyr Ser Glu Asp Thr Leu Val Arg Leu Thr Arg Arg Met 420 425 430 Leu Ala Asp Gly Val Asp Leu Tyr Thr Ala Arg Leu Gin Glu Phe Gly 435 440 445 Ile Glu Pro Ser Trp Thr Pro Pro Ala Pro Arg Ile Gly Glu Pro Val 450 455 460 Gly Asn Pro Ala Val Asp Arg Val Leu Lys Thr Val Ser Arg Trp Leu 465 470 475 480 Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 485 490 495 His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 500 505 510 Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gin Glu 515 520 525 Met Gin Glu Lys Leu Asn Val Gin Gly Lys Pro Ser Arg Ala Asp Leu 530 535 540 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 545 550 555 560 Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 565 570 575 Arg Ala Gly Gin Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 580 585 590 Cys His Arg Cys Asn Gin Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 595 600 605 Page 1942 of 3790 Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 610 615 620 Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 625 630 635 640 Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gin Arg Ala Thr Met 645 650 655 Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 660 665 670 Asn Glu Leu Arg Ser Arg Val Ala Gin His Phe Ala Ser His Gly Thr 675 680 685 Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 690 695 700 Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 705 710 715 720 Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 725 730 735 Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 740 745 750 Gin Ser Gin Ala His Arg Gin Glu Ala Pro Gin Trp Arg Glu Phe Thr 755 760 765 Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gin Lys 770 775 780 Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 785 790 795 800 Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 805 810 815 His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gin 820 825 830 Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 835 840 845 Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 850 855 860 Page 1943 of 3790 Lys Ala Val 995 Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 1000 1005 Gly Phe 1010 Phe Gly Asp Thr Arg 1015 Leu Arg Leu Arg Pro 1020 Leu Gin Met Ser Lys 1025 Glu Gly Ile Lys Lys 1030 Glu Ser Ala Pro Glu 1035 Leu Ser Lys Ile Ile Asp Arg Pro Gly 1040 Trp 1045 Leu Pro Ala Val Asn 1050 Lys Leu Phe Ser Glu 1055 Gly Asn Val Thr Val 1060 Val Arg Arg Asp Ser 1065 Leu Gly Arg Val Arg Leu 1070 Glu Ser Thr Ala 1075 His Leu Pro Val Thr 1080 Trp Lys Val Gin 928 Page 1944 of 3790 1084 PRT Corynebacterium diphtheriae 928 Arg Lys Ile Ile Asp Val Val Phe Ala Ala Glu Ser Pro Lys Gly Ser Page 1946 of 3790 Glu Ser Ala Thr Lys Thr Trp Gly Ala Pro Glu Arg Val Ile Ile Glu 485 490 495 His Val Arg Glu Gly Phe Val Thr Glu Lys Arg Ala Arg Glu Met Asp 500 505 510 Gly Asp Met Arg Arg Arg Ala Ala Arg Asn Ala Lys Leu Phe Gin Glu 515 520 525 Met Gin Glu Lys Leu Asn Ile Gin Gly Lys Pro Ser Arg Ala Asp Leu 530 535 540 Trp Arg Tyr Gin Ser Val Gin Arg Gin Asn Cys Gin Cys Ala Tyr Cys 545 550 555 560 Gly Ser Pro Ile Thr Phe Ser Asn Ser Glu Met Asp His Ile Val Pro 565 570 575 Arg Ala Gly Gin Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Val 580 585 590 Cys His Arg Cys Asn Gin Ser Lys Gly Asn Thr Pro Phe Ala Ile Trp 595 600 605 Ala Lys Asn Thr Ser Ile Glu Gly Val Ser Val Lys Glu Ala Val Glu 610 615 620 Arg Thr Arg His Trp Val Thr Asp Thr Gly Met Arg Ser Thr Asp Phe 625 630 635 640 Lys Lys Phe Thr Lys Ala Val Val Glu Arg Phe Gin Arg Val Thr Met 645 650 655 Asp Glu Glu Ile Asp Ala Arg Ser Met Glu Ser Val Ala Trp Met Ala 660 665 670 Asn Glu Leu Arg Ser Arg Val Ala Gin His Phe Ala Ser Arg Gly Thr 675 680 685 Thr Val Arg Val Tyr Arg Gly Ser Leu Thr Ala Glu Ala Arg Arg Ala 690 695 700 Ser Gly Ile Ser Gly Lys Leu Glu Phe Leu Asp Gly Val Gly Lys Ser 705 710 715 720 Arg Leu Asp Arg Arg His His Ala Ile Asp Ala Ala Val Ile Ala Phe 725 730 735 Page 1947 of 3790 Thr Ser Asp Tyr Val Ala Glu Thr Leu Ala Val Arg Ser Asn Leu Lys 740 745 750 Gin Ser Gin Ala His Arg Gin Glu Ala Pro Gin Trp Arg Glu Phe Thr 755 760 765 Gly Lys Asp Ala Glu His Arg Ala Ala Trp Arg Val Trp Cys Gin Lys 770 775 780 Met Glu Lys Leu Ser Ala Leu Leu Thr Glu Asp Leu Arg Asp Asp Arg 785 790 795 800 Val Val Val Met Ser Asn Val Arg Leu Arg Leu Gly Asn Gly Ser Ala 805 810 815 His Glu Glu Thr Ile Gly Lys Leu Ser Lys Val Lys Leu Gly Ser Gin 820 825 830 Leu Ser Val Ser Asp Ile Asp Lys Ala Ser Ser Glu Ala Leu Trp Cys 835 840 845 Ala Leu Thr Arg Glu Pro Asp Phe Asp Pro Lys Asp Gly Leu Pro Ala 850 855 860 Asn Pro Glu Arg His Ile Arg Val Asn Gly Thr His Val Tyr Ala Gly 865 870 875 880 Asp Asn Ile Gly Leu Phe Pro Val Ser Ala Gly Ser Ile Ala Leu Arg 885 890 895 Gly Gly Tyr Ala Glu Leu Gly Ser Ser Phe His His Ala Arg Val Tyr 900 905 910 Lys Ile Thr Ser Gly Lys Lys Pro Ala Phe Ala Met Leu Arg Val Tyr 915 920 925 Thr Ile Asp Leu Leu Pro Tyr Arg Asn Gin Asp Leu Phe Ser Val Glu 930 935 940 Leu Lys Pro Gin Thr Met Ser Met Arg Gin Ala Glu Lys Lys Leu Arg 945 950 955 960 Asp Ala Leu Ala Thr Gly Asn Ala Glu Tyr Leu Gly Trp Leu Val Val 965 970 975 Asp Asp Glu Leu Val Val Asp Thr Ser Lys Ile Ala Thr Asp Gin Val 980 985 990 Page 1948 of 3790 Lys Ala Val Glu Ala Glu Leu Gly Thr Ile Arg Arg Trp Arg Val Asp 995 1000 1005 Gin 929 1069 PRT Corynebacterium matruchotii 929 Met Ala Ala Ile Ala Ile Asp Asp Asp Gly Lys Pro Thr Glu Ile Leu 15 10 15 Ser Ala Ile Ser Leu Ile His Asp Ser Gly Val Asp Pro Asp Ser Ala 20 25 30 Lys Ser Ala Ala Thr Arg Leu Ala Thr Ser Gly Ile Ala Arg Arg Thr 35 40 45 Arg Arg Leu Tyr Arg Arg Lys Arg Lys Arg Leu Ala Lys Leu Asp Lys 50 55 60 Phe Ile Ser Ser Gin Gly Trp Pro Leu Lys Glu Phe Glu Lys Tyr Glu 65 70 75 80 Asp Pro Phe Tyr Pro Trp Arg Val Arg Ala Glu Leu Ala Thr Thr Ala 85 90 95 Ile Thr Asp Gin Gin Glu Leu Gly Glu Lys Leu Ser Ile Ala Leu Arg 100 105 110 Page 1949 of 3790 His Ile Ala Arg His Arg Gly Trp Arg Asn Pro Tyr Ser Lys Val Thr 115 120 125 Ala Leu Tyr Thr Val Thr Glu Pro Ser Asp Ala Phe Leu Ala Met Gin 130 135 140 Glu Glu Cys Ala Lys Gin Leu Gly Arg Thr Ile Pro Glu Thr Ile Thr 145 150 155 160 Val Gly Gin Leu Val Thr Gly Met Asn Leu Gly Lys Thr Arg Leu Arg 165 170 175 Gly Glu Asn Ser Leu Leu Ala Ala Arg Pro Arg Gin Ser Asp Asn Ala 180 185 190 Asn Glu Ile His Thr Ile Ala Lys Val Gin Gly Leu Ser Asn Glu Leu 195 200 205 Val Arg Gin Ile Ile Asp His Val Phe Ala Ala Glu Ser Pro Lys Gly 210 215 220 Ser Ala Ala Glu Gin Val Gly Lys Asp Pro Leu Gin Pro Thr Lys Lys 225 230 235 240 Arg Ala Leu Lys Ala Ser Asp Ala Phe Gin Gin Tyr Arg Ile Ala Ala 245 250 255 Leu Ile Gly Asn Leu Arg Ile Arg Gly Gly Lys Gly Asn Arg Arg Leu 260 265 270 Thr Thr Glu Glu Thr Arg Leu Val Phe Asp Tyr Leu Arg Ser Leu Pro 275 280 285 Ala Lys Gin Glu Pro Thr Trp Gin Leu Val Ala Glu Gin Leu Lys Ile 290 295 300 Asp Arg Gly Asn Leu Val Gly Thr Ala Ile Met Thr Asp Asp Gly Glu 305 310 315 320 Arg Ala Gly Ala Lys Pro Pro Val His Asp Thr Asn Arg Ile Met Glu 325 330 335 Asn Thr Lys Ile Lys Pro Leu Ala Thr Trp Trp Lys Ser Ala Asp Ala 340 345 350 Asp Ala Arg Ala Ala Met Val Lys Ala Leu Ser Asn Ala Glu Val Asp Page 1950 of 3790 355 360 365 Asp Phe Asp Ser Gin Ala Gly Ala Gin Val Gin Glu Phe Phe Phe Gly 370 375 380 Ile Ser Asp Glu Asp Gin Glu Lys Leu Asp Gly Leu His Leu Pro Ile 385 390 395 400 Gly Arg Ala Ala Tyr Ser Glu Asp Thr Leu Asp Arg Leu Thr Lys Arg 405 410 415 Met Ile Gly Glu Gly Met Asp Leu Tyr Glu Ala Arg Gin Ala Glu Phe 420 425 430 Lys Ile Ser Asn Asp Trp Ala Pro Pro Ala Pro Glu Ile Gly Glu Arg 435 440 445 Val Gly Asn Pro Ala Val Asp Arg Val Leu Lys Ala Thr Ala Arg Trp 450 455 460 Leu Asn Ala Ala Glu Arg Gin Trp Gly Ala Pro Lys Ser Val Asn Ile 465 470 475 480 Glu His Val Arg Ala Ala Phe Met Ser Glu Ser Ser Ala Arg Glu Leu 485 490 495 Asp Arg Asp Asn Gin Gin Arg Ala Lys Arg Asn Val Lys Val Val Ala 500 505 510 Glu Met Gin Glu Lys Leu Gly Ile Glu Gly Arg Pro Ser Arg Ala Asp 515 520 525 Val Trp Arg Phe Gin Ser Ile Gin Arg Gin Asn Gly Lys Cys Ala Tyr 530 535 540 Cys Gly Ala Glu Ile Ser Phe Lys Asn Ser Glu Met Asp His Ile Ile 545 550 555 560 Pro Gin Val Gly Glu Gly Ser Thr Asn Thr Arg Asp Asn Leu Val Ala 565 570 575 Val Cys Arg Glu Cys Asn Ser Ser Lys Ser Asn Ile Ala Phe Ala Val 580 585 590 Trp Ala Glu Asn Thr Ser Arg Pro Gly Val Ser Val Gin Lys Ala Ile 595 600 605 Page 1951 of 3790 Glu Arg Thr His His Trp Val Thr Asp Ser Gly Leu Arg Lys Pro Glu 610 615 620 Phe Asp Lys Phe Arg Lys Gin Val Cys Asp Arg Leu Arg Arg Lys Ala 625 630 635 640 Thr Asp Glu Pro Ile Asp Ala Arg Ser Leu Glu Ser Val Ala Trp Met 645 650 655 Ala Asn Glu Leu Arg Ser Arg Ile Ala Gin Lys Phe Lys Asp Gly Asp 660 665 670 Thr Lys Val Arg Val Tyr Lys Gly Ala Leu Thr Ala Glu Ala Arg Arg 675 680 685 Ala Ser Gly Ile Ser Gly Lys Leu Glu Phe Val Asp Gly Lys Gly Lys 690 695 700 Ser Arg Leu Asp Arg Arg His His Ala Val Asp Ala Ala Val Val Ala 705 710 715 720 Phe Thr Ser Asn Tyr Val Ala Glu Thr Leu Ala Leu Arg Ser Asn Met 725 730 735 Lys Phe Asp Gin Glu Leu Arg Arg Lys Ala Pro Gin Trp Arg Glu Phe 740 745 750 Thr Gly Ser Asp His Val His Gin Val Glu Trp Thr Lys Trp Lys Tyr 755 760 765 Arg Met Gin Ala Leu Ala Glu Leu Leu Asn Asn Ala Leu Val Gin Asp 770 775 780 Arg Ile Val Val Met His Asn Leu Arg Leu Arg Leu Gly Asn Gly Ala 785 790 795 800 Ala His Glu Asp Thr Ile Gly Lys Leu Thr Arg Leu Lys Val Gly Asp 805 810 815 Ala Ile Ser Thr Thr Asp Ile Asp Arg Ala Ser Ser Glu Ala Leu Trp 820 825 830 Cys Ala Leu Thr Arg Asp Pro Asp Tyr Asp Pro Lys Thr Gly Leu Pro 835 840 845 Glu Asn Pro Asn Arg Thr Ile Arg Ile His Gly Thr His Leu Thr Ala 850 855 860 Page 1952 of 3790 Lys 930 210 PRT Diplosphaera colitermitum 930 Page 1953 of 3790 Met Ser Asp Ile Leu Asp Lys Pro Ile Val Leu Ser Leu Asn Arg Ala 15 10 15 Trp Gin Val Ile Gly His Arg Thr Val Lys Gin Ala Leu Val Ala Leu 20 25 30 Asn Gly Gly Asn Ala Asp Leu Pro Pro Ala Leu Gly Leu Asp Ile Ala 35 40 45 Tyr Pro Lys Phe Asp Asp Gly Ala Trp Asn Phe Asp Arg Pro Leu Phe 50 55 60 Leu Asn Pro Leu Pro Trp Ser Glu Trp Ile Glu Leu Pro Val Arg Asp 65 70 75 80 Phe Asp Phe Ala Ile Thr Thr Pro Arg Leu Arg Ile Arg Val Pro Thr 85 90 95 Val Ile Val Ala Thr Gin Phe Ala Lys Met Pro Val Arg Ile Pro Arg 100 105 110 Leu Thr Arg Glu Ala Ile Phe Glu Arg Asp Gly Gly Val Cys Gin Tyr 115 120 125 Thr Gly Glu His Val Gly Lys His Gly Gly Asn Leu Asp His Val Val 130 135 140 Pro Arg Asp Arg Gly Gly Arg Asp Ser Phe Glu Asn Leu Val Trp Ala 145 150 155 160 Lys Arg Glu Ile Asn Ser Leu Lys Ala Asn Arg Leu Pro His Glu Ala 165 170 175 Gly Leu Arg Leu Leu Arg Arg Pro Lys Ala Pro Ala Pro Leu Pro Ala 180 185 190 Ser Met Thr Ile Arg Glu Ala Arg His Pro Asp Trp Arg His Phe Leu 195 200 205 Thr Pro 210 931 1332 PRT Dolosigranulum pigrum 931 Page 1954 of 3790 Met Gin Lys Asn Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Met Lys Asp Asp Tyr Thr Leu Ile Arg Lys Arg Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Ile Lys Lys Ile Lys Lys Asn Phe Trp 35 40 45 Gly Val Arg Leu Phe Asp Glu Gly Glu Thr Ala Lys Glu Thr Arg Leu 50 55 60 Lys Arg Gly Thr Arg Arg Arg Tyr Gin Arg Arg Arg Asn Arg Leu Ile 65 70 75 80 Tyr Leu Gin Asp Ile Phe Gin Gin Pro Met Leu Ala Ile Asp Glu Asn 85 90 95 Phe Phe His Arg Leu Asp Asp Ser Phe Phe Val Pro Asp Asp Lys Ser 100 105 110 Tyr Asp Arg His Pro Ile Phe Gly Ser Leu Glu Glu Glu Val Ala Tyr 115 120 125 His Asn Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 130 135 140 Asn Pro Glu Lys Ala Asp Leu Arg Leu Val Tyr Thr Ala Leu Ala His 145 150 155 160 Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 165 170 175 Glu Asn Thr Ser Ile Ser Glu Thr Phe Glu Gin Phe Leu Asp Thr Tyr 180 185 190 Ser Asp Ile Phe Lys Glu Gin Leu Val Gly Asp Ile Ser Lys Val Glu 195 200 205 Glu Ile Leu Ser Ser Lys Gin Ser Arg Ser Arg Lys His Glu Gin Ile 210 215 220 Met Ala Leu Phe Pro Asn Glu Asn Lys Leu Gly Asn Phe Gly Arg Phe 225 230 235 240 Met Met Leu Ile Val Gly Asn Thr Ser Asn Phe Lys Pro Val Phe Asp 245 250 255 Page 1955 of 3790 Leu Asp Asp Glu Tyr Lys Leu Lys Leu Ser Asp Glu Thr Tyr Glu Glu 260 265 270 Asp Leu Asp Thr Leu Leu Gly Met Thr Asp Asp Val Phe Leu Asp Val 275 280 285 Phe Met Ala Ala Lys Asn Val Tyr Asp Ala Val Glu Met Ser Ala Ile 290 295 300 Ile Ser Thr Asp Thr Gly Asn Ser Lys Ala Val Leu Ser Asn Gin Met 305 310 315 320 Ile Asn Phe Tyr Asp Glu His Lys Val Asp Leu Ala Gin Leu Lys Gin 325 330 335 Phe Phe Lys Thr His Leu Pro Asp Lys Tyr Tyr Glu Cys Phe Ser Asp 340 345 350 Pro Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gin 355 360 365 Glu Asp Phe Tyr Lys Tyr Ile Glu Lys Val Met Lys Thr Ile Lys Ser 370 375 380 Asp Lys Lys Asp Tyr Phe Leu Asp Lys Ile Asp Arg Glu Val Phe Leu 385 390 395 400 Arg Lys Gin Arg Ser Phe Tyr Asn Ser Val Ile Pro His Gin Ile His 405 410 415 Leu Gin Glu Met Gin Ala Ile Leu Asp Arg Gin Ser Gin Tyr Tyr Pro 420 425 430 Phe Leu Ala Glu Asn Arg Asp Lys Ile Glu Ser Leu Val Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Thr Val Ser Asp Gin Ser Glu Phe 450 455 460 Ala Trp Met Glu Arg Gin Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe 465 470 475 480 Asp Glu Ile Val Asn Lys Glu Arg Ser Ala Glu Lys Phe Ile Glu Arg 485 490 495 Met Thr Asn Met Asp Thr Tyr Leu Leu Glu Glu Lys Val Leu Pro Lys Page 1957 of 3790 Page 1958 of 3790 Page 1959 of 3790 Glu Thr Arg Tyr Lys Leu Glu Asp Asn 1325 1330 Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 115 120 125 Page 1960 of 3790 Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 130 135 140 Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gin Phe Tyr 145 150 155 160 Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 165 170 175 Asp Gin Phe Asn Ala Ser Phe Ser Thr Tyr Gin Asp Leu Leu Lys Cys 180 185 190 Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 195 200 205 Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gin Arg Ile 210 215 220 Arg Thr Gin Leu Ser Thr Phe Lys Gly Gin Phe Ser Ala Glu Val Leu 225 230 235 240 Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 245 250 255 Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 260 265 270 Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 275 280 285 Phe Met Gin Leu Ile Asn Asp Ser Gin Leu Ser Phe Lys Asn Ala Ile 290 295 300 Gin Lys Ala Gin Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 305 310 315 320 Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gin Ser 325 330 335 Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 340 345 350 Arg Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Ser Thr Gly 355 360 365 Lys Arg Arg Ser Ile Gin Arg Leu Lys Ile Val Glu Lys Ala Met Ala Page 1962 of 3790 Leu Arg Phe Phe Thr Glu Asp Glu Pro Arg Phe Thr Lys Asp Gly Glu 625 630 635 640 Ile Leu Trp Ser Asn Ser Tyr Leu Lys Thr Ile Lys Lys Glu Leu Asn 645 650 655 Tyr His Gin Met Asn Ile Val Lys Lys Val Glu Val Gin Lys Gly Gly 660 665 670 Phe Ser Lys Glu Ser Ile Lys Pro Lys Gly Pro Ser Asn Lys Leu Ile 675 680 685 Pro Val Lys Asn Gly Leu Asp Pro Gin Lys Tyr Gly Gly Phe Asp Ser 690 695 700 Pro Ile Val Ala Tyr Thr Val Leu Phe Thr His Glu Lys Gly Lys Lys 705 710 715 720 Pro Leu Ile Lys Gin Glu Ile Leu Gly Ile Thr Ile Met Glu Lys Thr 725 730 735 Arg Phe Glu Gin Asn Arg Ile Leu Phe Leu Glu Glu Lys Gly Phe Leu 740 745 750 Arg Pro Arg Val Leu Met Lys Leu Pro Lys Tyr Thr Leu Tyr Glu Phe 755 760 765 Pro Glu Gly Arg Arg Arg Leu Leu Ala Ser Ala Lys Glu Ala Gin Lys 770 775 780 Gly Asn Gin Met Val Leu Pro Glu His Leu Leu Thr Leu Leu Tyr His 785 790 795 800 Ala Lys Gin Cys Leu Leu Pro Asn Gin Ser Glu Ser Leu Thr Tyr Val 805 810 815 Glu Gin His Gin Pro Glu Phe Gin Glu Ile Leu Glu Arg Val Val Asp 820 825 830 Phe Ala Glu Val His Thr Leu Ala Lys Ser Lys Val Gin Gin Ile Val 835 840 845 Lys Leu Phe Glu Ala Asn Gin Thr Ala Asp Val Lys Glu Ile Ala Ala 850 855 860 Ser Phe Ile Gin Leu Met Gin Phe Asn Ala Met Gly Ala Pro Ser Thr 865 870 875 880 Page 1963 of 3790 Page 1964 of 3790 Glu Asn Ile Ser Val Lys Glu Gin Phe Gin Gin Phe Met Ile Ile Tyr 180 185 190 Asn Gin Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 195 200 205 Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 210 215 220 Thr Lys Lys Ser Glu Lys Val Leu Gin Gin Phe Pro Gin Glu Lys Ala 225 230 235 240 Asn Gly Leu Phe Gly Gin Phe Leu Lys Leu Met Val Gly Asn Lys Ala 245 250 255 Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 260 265 270 Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 275 280 285 Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 290 295 300 Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 305 310 315 320 Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gin Glu 325 330 335 Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 340 345 350 Tyr Asp Asn Leu Phe Lys Asn Glu Gin Lys Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Ala His Ala Gly Lys Val Ser Gin Leu Lys Phe Tyr Gin Tyr Val 370 375 380 Lys Lys Ile Ile Gin Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 385 390 395 400 Ile Ala Gin Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly 405 410 415 Val Ile Pro His Gin Ile His Leu Ala Glu Leu Gin Ala Ile Ile His 420 425 430 Page 1965 of 3790 Arg Gin Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gin Glu Lys Ile 435 440 445 Glu Gin Leu Val Thr Phe Arg Ile Pro Tyr Tyr Ile Gly Pro Leu Ser 450 455 460 Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gin Ser Glu Glu 465 470 475 480 Pro Ile Arg Pro Trp Asn Leu Gin Glu Thr Val Asp Leu Asp Gin Ser 485 490 495 Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Ser 500 505 510 Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 515 520 525 Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 530 535 540 Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 545 550 555 560 Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gin Phe Tyr 565 570 575 Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 580 585 590 Asp Gin Phe Asn Ala Ser Phe Ser Thr Tyr Gin Asp Leu Leu Lys Cys 595 600 605 Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 610 615 620 Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gin Arg Ile 625 630 635 640 Arg Thr Gin Leu Ser Thr Phe Lys Gly Gin Phe Ser Ala Glu Val Leu 645 650 655 Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 660 665 670 Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu Page 1966 of 3790 675 680 685 Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 690 695 700 Phe Met Gin Leu Ile Asn Asp Ser Gin Leu Ser Phe Lys Asn Ala Ile 705 710 715 720 Gin Lys Ala Gin Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 725 730 735 Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gin Ser 740 745 750 Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 755 760 765 Arg Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Ser Thr Gly 770 775 780 Lys Arg Arg Ser Ile Gin Arg Leu Lys Ile Val Glu Lys Ala Met Ala 785 790 795 800 Glu Ile Gly Ser Asn Leu Leu Lys Glu Gin Pro Thr Thr Asn Glu Gin 805 810 815 Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gin Asn Gly Lys Asp 820 825 830 Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 835 840 845 Ile Asp His Ile Ile Pro Gin Ser Phe Met Lys Asp Asp Ser Leu Asp 850 855 860 Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 865 870 875 880 Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 885 890 895 Leu Tyr Ala Ala Gly Leu Ile Ser Gin Arg Lys Phe Gin Arg Leu Thr 900 905 910 Lys Gly Glu Gin Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 915 920 925 Page 1967 of 3790 Page 1968 of 3790 934 1337 PRT Enterococcus faecalis 934 Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Met 20 Thr Glu Asp Tyr Gin 25 Leu Val Lys Lys Lys Met Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 35 40 45 Page 1969 of 3790 Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 65 70 75 80 Tyr Leu Gin Ala Phe Phe Glu Glu Ala Met Thr Ala Leu Asp Glu Asn 85 90 95 Phe Phe Ala Arg Leu Gin Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 100 105 110 Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 115 120 125 His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Ser Glu Gin Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 165 170 175 Glu Asn Ile Ser Val Lys Glu Gin Phe Gin Gin Phe Met Ile Ile Tyr 180 185 190 Asn Gin Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 195 200 205 Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 210 215 220 Thr Lys Lys Ser Glu Lys Val Leu Gin Gin Phe Pro Gin Glu Lys Ala 225 230 235 240 Asn Gly Leu Phe Gly Gin Phe Leu Lys Leu Met Val Gly Asn Lys Ala 245 250 255 Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 260 265 270 Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 275 280 285 Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 290 295 300 Page 1970 of 3790 Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 305 310 315 320 Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gin Glu 325 330 335 Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 340 345 350 Tyr Asp Asn Leu Phe Lys Asn Glu Gin Lys Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Thr His Ala Gly Lys Val Ser Gin Leu Lys Phe Tyr Gin Tyr Val 370 375 380 Lys Lys Ile Ile Gin Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 385 390 395 400 Ile Ala Gin Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly 405 410 415 Val Ile Pro His Gin Ile His Leu Ala Glu Leu Gin Ala Ile Ile His 420 425 430 Arg Gin Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gin Glu Lys Ile 435 440 445 Glu Gin Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 450 455 460 Lys Gly Asp Ala Asn Thr Phe Ala Trp Leu Lys Arg Gin Ser Glu Glu 465 470 475 480 Pro Ile Arg Pro Trp Asn Leu Gin Glu Thr Val Asp Leu Asp Gin Ser 485 490 495 Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 500 505 510 Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 515 520 525 Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 530 535 540 Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu Page 1972 of 3790 Page 1973 of 3790 Page 1974 of 3790 Pro Ser 1295 Thr Phe Lys Phe Phe 1300 Gin Lys Asp Ile Glu 1305 Arg Ala Arg Tyr Thr 1310 Ser Ile Lys Glu Ile 1315 Phe Asp Ala Thr Ile 1320 Ile Tyr Gin Ser Thr Thr Gly Leu Tyr Glu Thr Arg Arg Lys Val Val Asp 1325 1330 1335 935 1337 PRT Enterococcus faecalis 935 Page 1975 of 3790 Glu Asn Ile Ser Val Lys Glu Gin Phe Gin Gin Phe Met Ile Ile Tyr 180 185 190 Asn Gin Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Thr Pro Leu 195 200 205 Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 210 215 220 Thr Lys Lys Ser Glu Lys Val Leu Gin Gin Phe Pro Gin Glu Lys Ala 225 230 235 240 Asn Gly Leu Phe Gly Gin Phe Leu Lys Leu Met Val Gly Asn Lys Ala 245 250 255 Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 260 265 270 Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 275 280 285 Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 290 295 300 Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 305 310 315 320 Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gin Glu 325 330 335 Asp Leu Lys Asn Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 340 345 350 Tyr Asp Asn Leu Phe Lys Asn Glu Gin Lys Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Thr His Ala Gly Lys Val Ser Gin Leu Lys Phe Tyr Gin Tyr Val 370 375 380 Lys Lys Ile Ile Gin Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 385 390 395 400 Ile Ala Gin Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly 405 410 415 Val Ile Pro His Gin Ile His Leu Ala Glu Leu Gin Ala Ile Ile His Page 1977 of 3790 Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 675 680 685 Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 690 695 700 Phe Met Gin Leu Ile Asn Asp Ser Gin Leu Ser Phe Lys Asn Ala Ile 705 710 715 720 Gin Lys Ala Gin Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 725 730 735 Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gin Ser 740 745 750 Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 755 760 765 Arg Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Ser Thr Gly 770 775 780 Lys Arg Arg Ser Ile Gin Arg Leu Lys Ile Val Glu Lys Ala Met Ala 785 790 795 800 Glu Ile Gly Ser Asn Leu Leu Lys Glu Gin Pro Thr Thr Asn Glu Gin 805 810 815 Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gin Asn Gly Lys Asp 820 825 830 Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 835 840 845 Ile Asp His Ile Ile Pro Gin Ser Phe Met Lys Asp Asp Ser Leu Asp 850 855 860 Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 865 870 875 880 Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 885 890 895 Leu Tyr Ala Ala Gly Leu Ile Ser Gin Arg Lys Phe Gin Arg Leu Thr 900 905 910 Lys Gly Glu Gin Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 915 920 925 Page 1978 of 3790 Page 1979 of 3790 936 1337 PRT Enterococcus faecalis 936 Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Met 20 Thr Glu Asp Tyr Gin 25 Leu Val Lys Lys Lys Met Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 35 40 45 Page 1980 of 3790 Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 65 70 75 80 Tyr Leu Gin Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 85 90 95 Phe Phe Ala Arg Leu Gin Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 100 105 110 Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 115 120 125 His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Ser Glu Gin Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 165 170 175 Glu Asn Ile Ser Val Lys Glu Gin Phe Gin Gin Phe Met Ile Ile Tyr 180 185 190 Asn Gin Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 195 200 205 Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 210 215 220 Thr Lys Lys Ser Glu Lys Val Leu Gin Gin Phe Pro Gin Glu Lys Ala 225 230 235 240 Asn Gly Leu Phe Gly Gin Phe Leu Lys Leu Met Val Gly Asn Lys Ala 245 250 255 Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 260 265 270 Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 275 280 285 Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp Page 1982 of 3790 Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 545 550 555 560 Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gin Phe Tyr 565 570 575 Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 580 585 590 Asp Gin Phe Asn Ala Ser Phe Ser Thr Tyr Gin Asp Leu Leu Lys Cys 595 600 605 Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 610 615 620 Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gin Arg Ile 625 630 635 640 Arg Thr Gin Leu Ser Thr Phe Lys Gly Gin Phe Ser Ala Glu Val Leu 645 650 655 Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 660 665 670 Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 675 680 685 Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 690 695 700 Phe Met Gin Leu Ile Asn Asp Ser Gin Leu Ser Phe Lys Asn Ala Ile 705 710 715 720 Gin Lys Ala Gin Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 725 730 735 Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gin Ser 740 745 750 Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 755 760 765 Arg Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Ser Thr Gly 770 775 780 Lys Arg Arg Ser Ile Gin Arg Leu Lys Ile Val Glu Lys Ala Met Ala 785 790 795 800 Page 1983 of 3790 Page 1984 of 3790 Ala Ala Ser Phe Ile Gin Leu Met Gin Phe Asn Ala Met Gly Ala Page 1985 of 3790 1290 Gin Lys Asp Ile Glu Arg Ala Arg 1305 Phe Asp Ala Thr Ile Ile Tyr Gin 1320 Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr Ile Ala Gin Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly 405 410 415 Page 1987 of 3790 Val Ile Pro His Gin Ile His Leu Ala Glu Leu Gin Ala Ile Ile His 420 425 430 Arg Gin Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gin Glu Lys Ile 435 440 445 Glu Gin Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 450 455 460 Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gin Ser Glu Glu 465 470 475 480 Pro Ile Arg Pro Trp Asn Leu Gin Glu Thr Val Asp Leu Asp Gin Ser 485 490 495 Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 500 505 510 Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 515 520 525 Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 530 535 540 Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 545 550 555 560 Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gin Phe Tyr 565 570 575 Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 580 585 590 Asp Gin Phe Asn Ala Ser Phe Ser Thr Tyr Gin Asp Leu Leu Lys Cys 595 600 605 Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 610 615 620 Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gin Arg Ile 625 630 635 640 Arg Thr Gin Leu Ser Thr Phe Lys Gly Gin Phe Ser Ala Glu Val Leu 645 650 655 Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 660 665 670 Page 1988 of 3790 Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 675 680 685 Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 690 695 700 Phe Met Gin Leu Ile Asn Asp Ser Gin Leu Ser Phe Lys Asn Ala Ile 705 710 715 720 Gin Lys Ala Gin Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 725 730 735 Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gin Ser 740 745 750 Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 755 760 765 Arg Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Ser Thr Gly 770 775 780 Lys Arg Arg Ser Ile Gin Arg Leu Lys Ile Val Glu Lys Ala Met Ala 785 790 795 800 Glu Ile Gly Ser Asn Leu Leu Lys Glu Gin Pro Thr Thr Asn Glu Gin 805 810 815 Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gin Asn Gly Lys Asp 820 825 830 Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 835 840 845 Ile Asp His Ile Ile Pro Gin Ser Phe Met Lys Asp Asp Ser Leu Asp 850 855 860 Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 865 870 875 880 Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 885 890 895 Leu Tyr Ala Ala Gly Leu Ile Ser Gin Arg Lys Phe Gin Arg Leu Thr 900 905 910 Lys Gly Glu Gin Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 915 920 925 Page 1989 of 3790 Leu Asp Ile Gly Thr Asn Ser Val 10 15 Tyr Gin Leu Val Lys Lys Lys Met 25 30 Lys Lys Ile Lys Lys Asn Phe Trp 45 His Thr Ala Glu Asp Arg Arg Leu 60 Ser Arg Arg Arg Asn Arg Leu Arg 75 80 Ala Met Thr Asp Leu Asp Glu Asn 90 95 Phe Leu Val Pro Glu Asp Lys Lys 105 110 Lys Leu Glu Asp Glu Val Ala Tyr 125 His Leu Arg Lys Lys Leu Ala Asp 140 Leu Ile Tyr Leu Ala Leu Ala His 155 160 Leu Ile Glu Gly Lys Leu Ser Thr 170 175 Phe Gin Gin Phe Met Ile Ile Tyr 185 190 Ser Arg Leu Val Ser Ala Pro Leu 205 Page 1990 of 3790 Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 210 215 220 Thr Lys Lys Ser Glu Lys Val Leu Gin Gin Phe Pro Gin Glu Lys Ala 225 230 235 240 Asn Gly Leu Phe Gly Gin Phe Leu Lys Leu Met Val Gly Asn Lys Ala 245 250 255 Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 260 265 270 Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 275 280 285 Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 290 295 300 Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 305 310 315 320 Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gin Glu 325 330 335 Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 340 345 350 Tyr Asp Asn Leu Phe Lys Asn Glu Gin Lys Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Ala His Ala Gly Lys Val Ser Gin Leu Lys Phe Tyr Gin Tyr Val 370 375 380 Lys Lys Ile Ile Gin Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 385 390 395 400 Ile Ala Gin Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly 405 410 415 Val Ile Pro His Gin Ile His Leu Ala Glu Leu Gin Ala Ile Ile His 420 425 430 Arg Gin Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gin Glu Lys Ile 435 440 445 Glu Gin Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser Page 1992 of 3790 Phe Met Gin Leu Ile Asn Asp Ser Gin Leu Ser Phe Lys Asn Ala Ile 705 710 715 720 Gin Lys Ala Gin Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 725 730 735 Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gin Ser 740 745 750 Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 755 760 765 Arg Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Ser Thr Gly 770 775 780 Lys Arg Arg Ser Ile Gin Arg Leu Lys Ile Val Glu Lys Ala Met Ala 785 790 795 800 Glu Ile Gly Ser Asn Leu Leu Lys Glu Gin Pro Thr Thr Asn Glu Gin 805 810 815 Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gin Asn Gly Lys Asp 820 825 830 Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 835 840 845 Ile Asp His Ile Ile Pro Gin Ser Phe Met Lys Asp Asp Ser Leu Asp 850 855 860 Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 865 870 875 880 Val Pro Ser Lys Glu Val Val Lys Asp Met Lys Ala Tyr Trp Glu Lys 885 890 895 Leu Tyr Ala Ala Gly Leu Ile Ser Gin Arg Lys Phe Gin Arg Leu Thr 900 905 910 Lys Gly Glu Gin Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 915 920 925 Gin Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys Asn Val Ala Gly 930 935 940 Ile Leu Asn Gin Arg Tyr Asn Ala Asn Ser Lys Glu Lys Lys Val Gin 945 950 955 960 Page 1993 of 3790 Page 1994 of 3790 939 1337 PRT Enterococcus faecalis 939 Met Lys Lys Asp Tyr Val Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Met Thr Glu Asp Tyr Gin Leu Val Lys Lys Lys Met 20 25 30 Pro Ile Tyr Gly Asn Thr Glu Lys Lys Lys Ile Lys Lys Asn Phe Trp 35 40 45 Gly Val Arg Leu Phe Glu Glu Gly His Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Ile Ser Arg Arg Arg Asn Arg Leu Arg 65 70 75 80 Page 1995 of 3790 Tyr Leu Gin Ala Phe Phe Glu Glu Ala Met Thr Asp Leu Asp Glu Asn 85 90 95 Phe Phe Ala Arg Leu Gin Glu Ser Phe Leu Val Pro Glu Asp Lys Lys 100 105 110 Trp His Arg His Pro Ile Phe Ala Lys Leu Glu Asp Glu Val Ala Tyr 115 120 125 His Glu Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Ser Glu Gin Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Val Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Lys Leu Ser Thr 165 170 175 Glu Asn Ile Ser Val Lys Glu Gin Phe Gin Gin Phe Met Ile Ile Tyr 180 185 190 Asn Gin Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu 195 200 205 Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 210 215 220 Thr Lys Lys Ser Glu Lys Val Leu Gin Gin Phe Pro Gin Glu Lys Ala 225 230 235 240 Asn Gly Leu Phe Gly Gin Phe Leu Lys Leu Met Val Gly Asn Lys Ala 245 250 255 Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 260 265 270 Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 275 280 285 Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 290 295 300 Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 305 310 315 320 Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gin Glu Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gin Phe Tyr 565 570 575 Page 1997 of 3790 Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 580 585 590 Asp Gin Phe Asn Ala Ser Phe Ser Thr Tyr Gin Asp Leu Leu Lys Cys 595 600 605 Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 610 615 620 Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gin Arg Ile 625 630 635 640 Arg Thr Gin Leu Ser Thr Phe Lys Gly Gin Phe Ser Ala Glu Val Leu 645 650 655 Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 660 665 670 Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 675 680 685 Gly Tyr Leu Ile Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 690 695 700 Phe Met Gin Leu Ile Asn Asp Ser Gin Leu Ser Phe Lys Asn Ala Ile 705 710 715 720 Gin Lys Ala Gin Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 725 730 735 Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gin Ser 740 745 750 Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 755 760 765 Arg Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Ser Thr Gly 770 775 780 Lys Arg Arg Ser Ile Gin Arg Leu Lys Ile Val Glu Lys Ala Met Ala 785 790 795 800 Glu Ile Gly Ser Asn Leu Leu Lys Glu Gin Pro Thr Thr Asn Glu Gin 805 810 815 Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gin Asn Gly Lys Asp 820 825 830 Page 1998 of 3790 Lys Glu Leu Asn Tyr His Gin Met Asn Ile Val Lys Lys Val Glu 1070 1075 1080 Page 1999 of 3790 Tyr Thr Ser Ile Lys Glu Ile Phe Asp Ala Thr Ile Ile Tyr Gin Page 2000 of 3790 1310 1315 1320 Ser Thr Thr Gly Leu Tyr Glu Thr Arg Arg Lys Val Val Asp 1325 1330 1335 940 1337 PRT Enterococcus faecalis 940 Met Lys Lys Asp Tyr Val Ile Gly 1 5 Leu Asp Ile Gly Thr Asn Ser Val 10 15 Gly Trp Ala Val Met Thr Glu Asp 20 Tyr Gin Leu Val Lys Lys Lys Met 25 30 Pro Ile Tyr Gly Asn Thr Glu Lys 35 40 Lys Lys Ile Lys Lys Asn Phe Trp 45 Gly Val Arg Leu Phe Glu Glu Gly 50 55 His Thr Ala Glu Asp Arg Arg Leu 60 Lys Arg Thr Ala Arg Arg Arg Ile 65 70 Ser Arg Arg Arg Asn Arg Leu Arg 75 80 Tyr Leu Gin Ala Phe Phe Glu Glu 85 Ala Met Thr Asp Leu Asp Glu Asn 90 95 Phe Phe Ala Arg Leu Gin Glu Ser 100 Phe Leu Val Pro Glu Asp Lys Lys 105 110 Trp His Arg His Pro Ile Phe Ala 115 120 Lys Leu Glu Asp Glu Val Ala Tyr 125 His Glu Thr Tyr Pro Thr Ile Tyr 130 135 His Leu Arg Lys Lys Leu Ala Asp 140 Ser Ser Glu Gin Ala Asp Leu Arg 145 150 Leu Ile Tyr Leu Ala Leu Ala His 155 160 Ile Val Lys Tyr Arg Gly His Phe 165 Leu Ile Glu Gly Lys Leu Ser Thr 170 175 Glu Asn Thr Ser Val Lys Glu Gin 180 Phe Gin Gin Phe Met Val Ile Tyr 185 190 Asn Gin Thr Phe Val Asn Gly Glu Ser Arg Leu Val Ser Ala Pro Leu Page 2001 of 3790 195 200 205 Pro Glu Ser Val Leu Ile Glu Glu Glu Leu Thr Glu Lys Ala Ser Arg 210 215 220 Thr Lys Lys Ser Glu Lys Val Leu Gin Gin Phe Pro Gin Glu Lys Ala 225 230 235 240 Asn Gly Leu Phe Gly Gin Phe Leu Lys Leu Met Val Gly Asn Lys Ala 245 250 255 Asp Phe Lys Lys Val Phe Gly Leu Glu Glu Glu Ala Lys Ile Thr Tyr 260 265 270 Ala Ser Glu Ser Tyr Glu Glu Asp Leu Glu Gly Ile Leu Ala Lys Val 275 280 285 Gly Asp Glu Tyr Ser Asp Val Phe Leu Ala Ala Lys Asn Val Tyr Asp 290 295 300 Ala Val Glu Leu Ser Thr Ile Leu Ala Asp Ser Asp Lys Lys Ser His 305 310 315 320 Ala Lys Leu Ser Ser Ser Met Ile Val Arg Phe Thr Glu His Gin Glu 325 330 335 Asp Leu Lys Lys Phe Lys Arg Phe Ile Arg Glu Asn Cys Pro Asp Glu 340 345 350 Tyr Asp Asn Leu Phe Lys Asn Glu Gin Lys Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Ala His Ala Gly Lys Val Ser Gin Leu Lys Phe Tyr Gin Tyr Val 370 375 380 Lys Lys Ile Ile Gin Asp Ile Ala Gly Ala Glu Tyr Phe Leu Glu Lys 385 390 395 400 Ile Ala Gin Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly 405 410 415 Val Ile Pro His Gin Ile His Leu Ala Glu Leu Gin Ala Ile Ile His 420 425 430 Arg Gin Ala Ala Tyr Tyr Pro Phe Leu Lys Glu Asn Gin Glu Lys Ile 435 440 445 Page 2002 of 3790 Glu Gin Leu Val Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ser 450 455 460 Lys Gly Asp Ala Ser Thr Phe Ala Trp Leu Lys Arg Gin Ser Glu Glu 465 470 475 480 Pro Ile Arg Pro Trp Asn Leu Gin Glu Thr Val Asp Leu Asp Gin Ser 485 490 495 Ala Thr Ala Phe Ile Glu Arg Met Thr Asn Phe Asp Thr Tyr Leu Pro 500 505 510 Ser Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Met 515 520 525 Val Phe Asn Glu Leu Thr Lys Ile Ser Tyr Thr Asp Asp Arg Gly Ile 530 535 540 Lys Ala Asn Phe Ser Gly Lys Glu Lys Glu Lys Ile Phe Asp Tyr Leu 545 550 555 560 Phe Lys Thr Arg Arg Lys Val Lys Lys Lys Asp Ile Ile Gin Phe Tyr 565 570 575 Arg Asn Glu Tyr Asn Thr Glu Ile Val Thr Leu Ser Gly Leu Glu Glu 580 585 590 Asp Gin Phe Asn Ala Ser Phe Ser Thr Tyr Gin Asp Leu Leu Lys Cys 595 600 605 Gly Leu Thr Arg Ala Glu Leu Asp His Pro Asp Asn Ala Glu Lys Leu 610 615 620 Glu Asp Ile Ile Lys Ile Leu Thr Ile Phe Glu Asp Arg Gin Arg Ile 625 630 635 640 Arg Thr Gin Leu Ser Thr Phe Lys Gly Gin Phe Ser Ala Glu Val Leu 645 650 655 Lys Lys Leu Glu Arg Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 660 665 670 Lys Leu Ile Asn Gly Ile Tyr Asp Lys Glu Ser Gly Lys Thr Ile Leu 675 680 685 Asp Tyr Leu Val Lys Asp Asp Gly Val Ser Lys His Tyr Asn Arg Asn 690 695 700 Page 2003 of 3790 Phe Met Gin Leu Ile Asn Asp Ser Gin Leu Ser Phe Lys Asn Ala Ile 705 710 715 720 Gin Lys Ala Gin Ser Ser Glu His Glu Glu Thr Leu Ser Glu Thr Val 725 730 735 Asn Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Tyr Gin Ser 740 745 750 Leu Lys Ile Val Asp Glu Leu Val Ala Ile Met Gly Tyr Ala Pro Lys 755 760 765 Arg Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Ser Thr Gly 770 775 780 Lys Arg Arg Ser Ile Gin Arg Leu Lys Ile Val Glu Lys Ala Met Ala 785 790 795 800 Glu Ile Gly Ser Asn Leu Leu Lys Glu Gin Pro Thr Thr Asn Glu Gin 805 810 815 Leu Arg Asp Thr Arg Leu Phe Leu Tyr Tyr Met Gin Asn Gly Lys Asp 820 825 830 Met Tyr Thr Gly Asp Glu Leu Ser Leu His Arg Leu Ser His Tyr Asp 835 840 845 Ile Asp His Ile Ile Pro Gin Ser Phe Met Lys Asp Asp Ser Leu Asp 850 855 860 Asn Leu Val Leu Val Gly Ser Thr Glu Asn Arg Gly Lys Ser Asp Asp 865 870 875 880 Val Pro Ser Lys Lys Val Val Lys Lys Met Lys Ala Tyr Trp Glu Lys 885 890 895 Leu Tyr Ala Ala Gly Leu Ile Ser Gin Arg Lys Phe Gin Arg Leu Thr 900 905 910 Lys Gly Glu Gin Gly Gly Leu Thr Leu Glu Asp Lys Ala His Phe Ile 915 920 925 Gin Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys Asn Val Ala Gly 930 935 940 Ile Leu Asp Gin Arg Tyr Asn Ala Lys Ser Lys Glu Lys Lys Val Gin 945 950 955 960 Page 2004 of 3790 Arg Arg Leu Leu Ala Ser Ala Lys Glu Ala Gin Lys Gly Asn Gin 941 1150 PRT Enterococcus faecalis 941 Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 15 10 15 Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 20 25 30 Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 35 40 45 Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 50 55 60 Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys Page 2007 of 3790 Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 325 330 335 Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 340 345 350 Arg Asn Trp Arg Lys Ile Phe Ala Glu Ser Gly Ile Asp Leu Ala Met 355 360 365 Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Ile Leu Thr Leu Asn 370 375 380 Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 385 390 395 400 Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 405 410 415 Ser Gin Ser Val Ser Thr Gin Ala Trp His Arg Phe Ser Leu Lys Thr 420 425 430 Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gin Asn 435 440 445 Thr Leu Leu Glu Gin Phe Gin Leu Lys Ser Asp Val Arg Lys Arg Tyr 450 455 460 Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 465 470 475 480 Asn Pro Thr Val Asn Lys Thr Val Ser Gin Ala Phe Lys Val Ile Asp 485 490 495 Ala Leu Leu Val Lys Tyr Gly Lys Glu Gin Ile Arg Tyr Ile Thr Ile 500 505 510 Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 515 520 525 Glu Leu His Ala Lys Asn Ser Gin Arg Lys Asn Asp Ser Gin Ser Tyr 530 535 540 Phe Met Gin Lys Ser Gly Trp Ser Gin Glu Lys Phe Gin Thr Thr Ile 545 550 555 560 Gin Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gin 565 570 575 Page 2008 of 3790 Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 580 585 590 Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 595 600 605 Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 610 615 620 Gin Val Lys Gly Gin Gin Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 625 630 635 640 Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gin Lys 645 650 655 Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 660 665 670 Glu Thr Arg Asn Ile Phe Asp Ser Glu Gin Val Glu Lys Phe Leu Ala 675 680 685 Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 690 695 700 Leu Gin Ser Phe Phe Ala Asn Gin Glu Thr Lys Val Arg Val Val Asn 705 710 715 720 Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 725 730 735 Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 740 745 750 Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 755 760 765 Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 770 775 780 Glu Ile Val Asp Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 785 790 795 800 Tyr Glu Arg Lys Thr Tyr Gin Val Lys Trp Pro Asn Phe Arg Glu Gin 805 810 815 Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gin Val 820 825 830 Page 2009 of 3790 Ser Gin Arg Tyr Asp Val Arg Phe Tyr Asn Phe Gin Ser Ala Asn Page 2010 of 3790 1070 1075 1080 Gin Asp Tyr Lys Glu Gin Val Arg Lys Asn Ala Gin Leu Leu Thr Lys Page 2012 of 3790 Thr Glu His Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 385 390 395 400 Leu Ala Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 405 410 415 Ser Gin Ser Val Ser Thr Gin Ala Trp His Arg Phe Ser Leu Lys Thr 420 425 430 Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gin Asn 435 440 445 Thr Leu Leu Glu Gin Phe Gin Leu Lys Ser Asp Val Arg Lys Arg Tyr 450 455 460 Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Thr Glu Ile Tyr 465 470 475 480 Asn Pro Thr Val Asn Lys Thr Val Ser Gin Ala Phe Lys Val Ile Asp 485 490 495 Ala Leu Leu Val Lys Tyr Gly Lys Glu Gin Ile Arg Tyr Ile Thr Ile 500 505 510 Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 515 520 525 Glu Leu His Ala Lys Asn Ser Gin Arg Lys Asn Asp Ser Gin Ser Tyr 530 535 540 Phe Met Gin Lys Ser Gly Trp Ser Gin Glu Lys Phe Gin Thr Thr Ile 545 550 555 560 Gin Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gin 565 570 575 Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 580 585 590 Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 595 600 605 Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 610 615 620 Gin Val Lys Gly Gin Gin Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 625 630 635 640 Page 2013 of 3790 Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gin Lys 645 650 655 Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 660 665 670 Glu Thr Arg Asn Ile Phe Asp Ser Glu Gin Val Glu Lys Phe Leu Ala 675 680 685 Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 690 695 700 Leu Gin Ser Phe Phe Ala Asn His Glu Thr Lys Val Arg Val Val Asn 705 710 715 720 Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 725 730 735 Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 740 745 750 Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 755 760 765 Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 770 775 780 Glu Ile Val Asp Glu Met Ser Tyr Gin Glu Phe Lys Lys Ser Lys Lys 785 790 795 800 Tyr Glu Arg Lys Thr Tyr Gin Val Lys Trp Pro Asn Phe Arg Glu Gin 805 810 815 Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gin Val 820 825 830 Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 835 840 845 Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gin Lys Ile 850 855 860 Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Val 865 870 875 880 Asp Gly Trp Glu Ala Phe Lys Lys Lys Gin Asp Lys Leu Leu Met Lys 885 890 895 Page 2014 of 3790 Asn Thr Asp Ile Leu Gly Lys Lys His Tyr Leu Tyr Tyr Glu Lys Page 2015 of 3790 Gin Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe Page 2016 of 3790 195 200 205 Val Gin Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 210 215 220 Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 225 230 235 240 Arg Trp Ser Asp Phe Gin Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 245 250 255 Asp Lys Leu Ile Gly Lys Asp Phe Gin Gly Glu Leu Arg Ala Ser Gly 260 265 270 Leu Ser Leu Ser Ala Gin Gin Tyr Asn Leu Leu Asn Asp Leu Thr Asn 275 280 285 Leu Lys Ile Asp Gly Glu Val Pro Leu Ser Ser Glu Gin Lys Glu Tyr 290 295 300 Ile Leu Thr Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Val Asn 305 310 315 320 Asp Val Val Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp 325 330 335 Arg Leu Asp Lys Lys Gly Lys Pro Glu Ile His Thr Leu Lys Gly Tyr 340 345 350 Arg Asn Trp Arg Lys Ile Phe Ala Glu Ala Gly Ile Asp Leu Ala Thr 355 360 365 Leu Pro Thr Glu Thr Ile Asp Cys Leu Ala Lys Val Leu Thr Leu Asn 370 375 380 Thr Glu Arg Glu Gly Ile Glu Asn Thr Leu Ala Phe Glu Leu Pro Glu 385 390 395 400 Leu Ser Glu Ser Val Lys Leu Leu Val Leu Asp Arg Tyr Lys Glu Leu 405 410 415 Ser Gin Ser Ile Ser Thr Gin Ser Trp His Arg Phe Ser Leu Lys Thr 420 425 430 Leu His Leu Leu Ile Pro Glu Leu Met Asn Ala Thr Ser Glu Gin Asn 435 440 445 Page 2017 of 3790 Thr Leu Leu Glu Gin Phe Gin Leu Lys Ser Asp Val Arg Lys Arg Tyr 450 455 460 Ser Glu Tyr Lys Lys Leu Pro Thr Lys Asp Val Leu Ala Glu Ile Tyr 465 470 475 480 Asn Pro Thr Val Asn Lys Thr Val Ser Gin Ala Phe Lys Val Ile Asp 485 490 495 Ala Leu Leu Val Lys Tyr Gly Lys Glu Gin Ile Arg Tyr Ile Thr Ile 500 505 510 Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 515 520 525 Glu Leu His Ala Lys Asn Ser Gin Arg Lys Asn Asp Ser Gin Ser Tyr 530 535 540 Phe Met Gin Lys Ser Gly Trp Ser Gin Glu Lys Phe Gin Thr Thr Ile 545 550 555 560 Gin Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gin 565 570 575 Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 580 585 590 Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 595 600 605 Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 610 615 620 Gin Val Lys Gly Gin Gin Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 625 630 635 640 Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gin Lys 645 650 655 Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 660 665 670 Glu Thr Arg Asn Ile Phe Asp Ser Glu Gin Val Glu Lys Phe Leu Ala 675 680 685 Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 690 695 700 Page 2018 of 3790 Leu Gin Ser Phe Phe Thr Asn Gin Glu Thr Lys Val Arg Val Val Asn 705 710 715 720 Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 725 730 735 Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 740 745 750 Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 755 760 765 Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 770 775 780 Glu Ile Val Asn Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 785 790 795 800 Tyr Glu Arg Lys Thr Tyr Gin Val Lys Trp Pro Asn Phe Arg Glu Gin 805 810 815 Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gin Val 820 825 830 Asp Arg Lys Ala Asn Arg Lys Leu Ser Asp Ala Thr Ile Tyr Ser Val 835 840 845 Arg Glu Lys Thr Glu Val Lys Thr Leu Lys Ser Gly Lys Gin Lys Ile 850 855 860 Thr Thr Asp Glu Tyr Thr Ile Gly Lys Ile Lys Asp Ile Tyr Thr Leu 865 870 875 880 Asp Gly Trp Glu Ala Phe Lys Lys Lys Gin Asp Lys Leu Leu Met Lys 885 890 895 Asp Leu Asp Glu Lys Thr Tyr Glu Arg Leu Leu Ser Ile Ala Glu Thr 900 905 910 Thr Pro Asp Phe Gin Glu Val Glu Glu Lys Asn Gly Lys Val Lys Arg 915 920 925 Val Lys Arg Ser Pro Phe Ala Val Tyr Cys Glu Glu Asn Asp Ile Pro 930 935 940 Ala Ile Gin Lys Tyr Ala Lys Lys Asn Asn Gly Pro Leu Ile Arg Ser 945 950 955 960 Page 2019 of 3790 Leu Lys Tyr Tyr Asp Gly Lys Leu Asn Lys His Ile Asn Ile Thr Lys 965 970 975 Asp Ser Gin Gly Arg Pro Val Glu Lys Thr Lys Asn Gly Arg Lys Val 980 985 990 Thr Leu Gin Ser Leu Lys Pro Tyr Arg Tyr Asp Ile Tyr Gin Asp Leu 995 1000 1005 Glu Thr Lys Ala Tyr Tyr Thr Val Gin Leu Tyr Tyr Ser Asp Leu 1010 1015 1020 Arg Phe Val Glu Gly Lys Tyr Gly Ile Thr Glu Lys Glu Tyr Met 1025 1030 1035 Lys Lys Val Ala Glu Gin Thr Lys Gly Gin Val Val Arg Phe Cys 1040 1045 1050 Phe Ser Leu Gin Lys Asn Asp Gly Leu Glu Ile Glu Trp Lys Asp 1055 1060 1065 Ser Gin Arg Tyr Asp Val Arg Phe Tyr Asn Phe Gin Ser Ala Asn 1070 1075 1080 Ser Ile Asn Phe Lys Gly Leu Glu Gin Glu Ile Met Pro Ala Glu 1085 1090 1095 Asn Gin Phe Lys Gin Lys Pro Tyr Asn Asn Gly Ala Ile Asn Leu 1100 1105 1110 Asn Ile Ala Lys Tyr Gly Lys Glu Gly Lys Lys Leu Arg Lys Phe 1115 1120 1125 Asn Thr Asp Ile Leu Gly Lys Lys His Tyr Leu Phe Tyr Glu Lys 1130 1135 1140 Glu Pro Lys Asn Ile Ile Lys 1145 1150 944 1150 PRT Enterococcus faecalis 944 Met Tyr Ser Ile Gly Leu Asp Leu Gly Ile Ser Ser Val Gly Trp Ser 15 10 15 Page 2020 of 3790 Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 20 25 30 Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 35 40 45 Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 50 55 60 Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 65 70 75 80 Asn Ser Cys Pro Tyr Gin Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 85 90 95 Ser Arg Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 100 105 110 Gly Ile Ser Tyr Leu Asp Glu Val Asp Thr Glu Ala Ala Lys Glu Ser 115 120 125 Gin Asp Tyr Lys Glu Gin Val Arg Lys Asn Ala Gin Leu Leu Thr Lys 130 135 140 Tyr Thr Pro Gly Gin Ile Gin Leu Gin Arg Leu Lys Glu Asn Asn Arg 145 150 155 160 Val Lys Thr Gly Ile Asn Ala Gin Gly Asn Tyr Gin Leu Asn Val Phe 165 170 175 Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gin 180 185 190 Gin Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 195 200 205 Val Gin Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 210 215 220 Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 225 230 235 240 Arg Trp Ser Asp Phe Gin Lys Thr Gly Glu Pro Ala Thr Asn Ile Phe 245 250 255 Asp Lys Leu Ile Gly Lys Asp Phe Gin Gly Glu Leu Arg Ala Ser Gly Page 2022 of 3790 Glu Met Pro Arg Asp Asp Asn Glu Glu Asp Glu Lys Lys Arg Ile Lys 515 520 525 Glu Leu His Ala Lys Asn Ser Gin Arg Lys Asn Asp Ser Gin Ser Tyr 530 535 540 Phe Met Gin Lys Ser Gly Trp Ser Gin Glu Lys Phe Gin Thr Thr Ile 545 550 555 560 Gin Lys Asn Arg Arg Phe Leu Ala Lys Leu Leu Tyr Tyr Tyr Glu Gin 565 570 575 Asp Gly Ile Cys Ala Tyr Thr Gly Leu Pro Ile Ser Pro Glu Leu Leu 580 585 590 Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 595 600 605 Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 610 615 620 Gin Val Lys Gly Gin Gin Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 625 630 635 640 Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gin Lys 645 650 655 Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 660 665 670 Glu Thr Arg Asn Ile Phe Asp Ser Glu Gin Val Glu Lys Phe Leu Ala 675 680 685 Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 690 695 700 Leu Gin Ser Phe Phe Thr Asn Gin Glu Thr Lys Val Arg Val Val Asn 705 710 715 720 Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 725 730 735 Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 740 745 750 Ala Val Thr Ser Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 755 760 765 Page 2023 of 3790 Glu Thr Lys Ala Tyr Tyr Thr Val Gin Leu Tyr Tyr Ser Asp Leu 1010 1015 1020 Page 2024 of 3790 1145 1150 945 1150 PRT Enterococcus faecalis 945 Met Tyr Ser Ile Gly Leu Asp Leu Gly Val Ser Ser Val Gly Trp Ser 15 10 15 Val Ile Asp Glu Arg Thr Gly Asn Val Ile Asp Leu Gly Val Arg Leu 20 25 30 Phe Ser Ala Lys Asn Ser Glu Lys Asn Leu Glu Arg Arg Thr Asn Arg 35 40 45 Gly Gly Arg Arg Leu Ile Arg Arg Lys Thr Asn Arg Leu Lys Asp Ala 50 55 60 Lys Lys Ile Leu Ala Ala Val Gly Phe Tyr Glu Asp Lys Ser Leu Lys 65 70 75 80 Page 2025 of 3790 Asn Ser Cys Pro Tyr Gin Leu Arg Val Lys Gly Leu Thr Glu Pro Leu 85 90 95 Ser Lys Gly Glu Ile Tyr Lys Val Thr Leu His Ile Leu Lys Lys Arg 100 105 110 Gly Ile Ser Tyr Leu Asp Glu Asp Asp Thr Glu Ala Ala Lys Glu Ser 115 120 125 Gin Asp Tyr Lys Glu Gin Val Arg Glu Asn Ala Gin Leu Leu Thr Lys 130 135 140 Tyr Thr Pro Gly Gin Ile Gin Leu Gin Arg Leu Lys Glu Asn Asn Arg 145 150 155 160 Val Lys Thr Gly Ile Asn Ala Gin Gly Asn Tyr Gin Leu Asn Val Phe 165 170 175 Lys Val Ser Ala Tyr Ala Asn Glu Leu Ala Thr Ile Leu Lys Thr Gin 180 185 190 Gin Ala Phe Tyr Pro Asn Glu Leu Thr Asp Asp Trp Ile Ala Leu Phe 195 200 205 Val Gin Pro Gly Ile Ala Glu Glu Ala Gly Leu Ile Tyr Arg Lys Arg 210 215 220 Pro Tyr Tyr His Gly Pro Gly Asn Glu Ala Asn Asn Ser Pro Tyr Gly 225 230 235 240 Arg Trp Ser Asp Phe Lys Lys Thr Gly Gin Pro Ala Thr Asn Ile Phe 245 250 255 Asp Lys Leu Ile Gly Lys Asp Phe Gin Gly Glu Leu Arg Ala Ser Gly 260 265 270 Leu Ser Leu Ser Ala Gin Gin Tyr Asn Leu Leu Asn Asp Leu Thr Asn 275 280 285 Leu Lys Ile Asp Gly Glu Ile Pro Leu Ser Pro Glu Gin Lys Glu Tyr 290 295 300 Ile Leu Ala Glu Leu Met Thr Lys Glu Phe Thr Arg Phe Gly Ile Asn 305 310 315 320 Asp Val Ala Lys Leu Leu Gly Val Lys Lys Glu Arg Leu Ser Gly Trp Page 2027 of 3790 Asp Gly Ile Cys Ala Tyr Thr Gly Leu Ser Ile Ser Pro Glu Leu Leu 580 585 590 Val Ser Asp Ser Thr Glu Ile Asp His Ile Ile Pro Ile Ser Ile Ser 595 600 605 Leu Asp Asp Ser Ile Asn Asn Lys Val Leu Val Leu Ser Lys Ala Asn 610 615 620 Gin Val Lys Gly Gin Gin Thr Pro Tyr Asp Ala Trp Met Asp Gly Ser 625 630 635 640 Phe Lys Lys Ile Asn Gly Lys Phe Ser Asn Trp Asp Asp Tyr Gin Lys 645 650 655 Trp Val Glu Ser Arg His Phe Ser His Lys Lys Glu Asn Asn Leu Leu 660 665 670 Glu Thr Arg Asn Ile Phe Asp Ser Glu Gin Val Glu Lys Phe Leu Ala 675 680 685 Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Leu Val Leu Asn Thr 690 695 700 Leu Gin Ser Phe Phe Ala Asn Gin Glu Thr Lys Val Arg Val Val Asn 705 710 715 720 Gly Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ala Asp Leu Asp 725 730 735 Lys Thr Arg Glu Thr His His His His Ala Val Asp Ala Thr Leu Cys 740 745 750 Ala Val Thr Pro Phe Val Lys Val Ser Arg Tyr His Tyr Ala Val Lys 755 760 765 Glu Glu Thr Gly Glu Lys Val Met Arg Glu Ile Asp Phe Glu Thr Gly 770 775 780 Glu Ile Val Asp Glu Met Ser Tyr Arg Glu Phe Lys Lys Ser Lys Lys 785 790 795 800 Tyr Glu Arg Lys Thr Tyr Gin Val Lys Trp Pro Asn Phe Arg Glu Gin 805 810 815 Leu Lys Pro Val Asn Leu His Pro Arg Ile Lys Phe Ser His Gin Val 820 825 830 Page 2028 of 3790 Ser Gin Cys Tyr Asp Val Arg Phe Tyr Asn Phe Gin Ser Ala Asn 1070 1075 1080 Page 2029 of 3790 1145 1150 946 1340 PRT Enterococcus faecium 946 Page 2030 of 3790 Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 145 150 155 160 Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 165 170 175 Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gin Phe Leu Ser Thr Tyr 180 185 190 Asn Gin Gin Phe Ser Glu Ala Asp Asp Lys Gin Thr Glu Lys Leu Asp 195 200 205 Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 210 215 220 Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 225 230 235 240 Gly Tyr Leu Ser Gin Phe Ile Lys Leu Met Val Gly Asn Gin Gly Asn 245 250 255 Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gin Phe Ser 260 265 270 Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 275 280 285 Asp Asp Tyr Ile Asp Leu Phe Val Gin Ala Lys Asn Val Tyr Asp Ala 290 295 300 Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 305 310 315 320 Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 325 330 335 Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 340 345 350 Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 355 360 365 Glu Gly His Ala Thr Gin Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 370 375 380 Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gin Page 2032 of 3790 Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 645 650 655 Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 660 665 670 Lys Glu Leu Ile Gin Gly Ile Arg Asp Lys Gin Ser Asn Lys Thr Ile 675 680 685 Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 690 695 700 Asn Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 705 710 715 720 Ile Lys Lys Ala Gin Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 725 730 735 Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin 740 745 750 Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 755 760 765 Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Arg 770 775 780 Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 785 790 795 800 Lys Asp Phe Gly Ser Gin Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 805 810 815 Ser Leu Gin Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Arg 820 825 830 Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 835 840 845 Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 850 855 860 Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 865 870 875 880 Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 885 890 895 Page 2033 of 3790 Thr Val Ala Phe Thr Tyr Glu Lys Gly Lys Ala Arg Lys Arg Thr 1130 1135 1140 Page 2034 of 3790 Gly Lys 1340 947 1339 PRT Enterococcus faecium Page 2035 of 3790 947 Met Lys Lys Glu Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ser Val Leu Thr Asp Asp Tyr Arg Leu Val Ser Lys Lys Met 20 25 30 Lys Val Ala Gly Asn Thr Glu Lys Ser Ser Thr Lys Lys Asn Phe Trp 35 40 45 Gly Val Arg Leu Phe Asp Glu Gly Gin Thr Ala Glu Ala Arg Arg Ser 50 55 60 Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gin Arg Ile Leu 65 70 75 80 Glu Leu Gin Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 85 90 95 Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 100 105 110 Gin Ser Arg His Pro Val Phe Ala Thr Ile Lys Gin Glu Lys Ser Tyr 115 120 125 His Gin Thr Tyr Pro Thr Ile Tyr His Leu Arg Gin Ala Leu Ala Asp 130 135 140 Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 145 150 155 160 Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 165 170 175 Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gin Phe Leu Ser Thr Tyr 180 185 190 Asn Gin Gin Phe Ser Glu Ala Asp Asp Lys Gin Thr Glu Lys Leu Asp 195 200 205 Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 210 215 220 Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 225 230 235 240 Gly Tyr Leu Ser Gin Phe Ile Lys Leu Met Val Gly Asn Gin Gly Asn Page 2037 of 3790 Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn Lys 500 505 510 Val Leu Pro Lys Asn Ser Leu Leu Tyr Gin Lys Phe Ser Ile Tyr Asn 515 520 525 Glu Leu Thr Lys Val Arg Tyr Gin Asp Glu Arg Gly Gin Met Asn Tyr 530 535 540 Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu Lys 545 550 555 560 Asn Arg Lys Val Thr Lys Lys Asp Leu Gin Glu Phe Leu Tyr Leu Lys 565 570 575 Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe Asn 580 585 590 Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn Lys 595 600 605 Arg Glu Met Lys Gin Trp Leu Glu Asp Pro Glu Leu Ala Ser Met Phe 610 615 620 Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met Ile 625 630 635 640 Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile Ile 645 650 655 Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 660 665 670 Glu Leu Ile Gin Gly Ile Arg Asp Lys Gin Ser Asn Lys Thr Ile Leu 675 680 685 Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg Asn 690 695 700 Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu Ile 705 710 715 720 Lys Lys Ala Gin Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile Val 725 730 735 Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser 740 745 750 Page 2038 of 3790 Page 2039 of 3790 Val Asn Glu His His Lys Glu Phe Ser Glu Val Phe Ala Arg Val Page 2040 of 3790 1235 1240 1245 Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys Page 2042 of 3790 Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 355 360 365 Glu Gly His Ala Thr Gin Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 370 375 380 Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gin 385 390 395 400 Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile Pro 405 410 415 His Gin Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gin Lys 420 425 430 Lys His Tyr Pro Phe Leu Lys Glu Glu Gin Glu Lys Leu Glu Ser Leu 435 440 445 Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gin 450 455 460 Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 465 470 475 480 Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 485 490 495 Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn 500 505 510 Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gin Lys Phe Ser Ile Tyr 515 520 525 Asn Glu Leu Thr Lys Val Arg Tyr Gin Asp Glu Arg Gly Gin Met Asn 530 535 540 Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 545 550 555 560 Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gin Glu Phe Leu Tyr Leu 565 570 575 Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 580 585 590 Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 595 600 605 Page 2043 of 3790 Lys Arg Glu Met Lys Gin Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 610 615 620 Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 625 630 635 640 Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 645 650 655 Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 660 665 670 Lys Glu Leu Ile Gin Gly Ile Arg Asp Lys Gin Ser Asn Lys Thr Ile 675 680 685 Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 690 695 700 Asn Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 705 710 715 720 Ile Lys Lys Ala Gin Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 725 730 735 Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin 740 745 750 Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 755 760 765 Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Arg 770 775 780 Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 785 790 795 800 Lys Asp Phe Gly Ser Gin Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 805 810 815 Ser Leu Gin Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Arg 820 825 830 Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 835 840 845 Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 850 855 860 Page 2044 of 3790 Pro Lys Lys Asp Ser Ser Lys Leu Leu Pro Arg Lys Asn Asn Trp Page 2046 of 3790 Gly Lys 1340 949 1340 PRT Enterococcus faecium 949 Page 2047 of 3790 Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 210 215 220 Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 225 230 235 240 Gly Tyr Leu Ser Gin Phe Ile Lys Leu Met Val Gly Asn Gin Gly Asn 245 250 255 Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gin Phe Ser 260 265 270 Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 275 280 285 Asp Asp Tyr Ile Asp Leu Phe Val Gin Ala Lys Asn Val Tyr Asp Ala 290 295 300 Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 305 310 315 320 Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 325 330 335 Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 340 345 350 Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 355 360 365 Glu Gly His Ala Thr Gin Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 370 375 380 Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gin 385 390 395 400 Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile Pro 405 410 415 His Gin Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gin Lys 420 425 430 Lys His Tyr Pro Phe Leu Lys Glu Glu Gin Glu Lys Leu Glu Ser Leu 435 440 445 Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gin 450 455 460 Page 2048 of 3790 Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 465 470 475 480 Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 485 490 495 Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 500 505 510 Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gin Lys Phe Ser Ile Tyr 515 520 525 Asn Glu Leu Thr Lys Val Arg Tyr Gin Asp Glu Arg Gly Gin Met Asn 530 535 540 Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 545 550 555 560 Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gin Glu Phe Leu Tyr Leu 565 570 575 Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 580 585 590 Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 595 600 605 Lys Arg Glu Met Lys Gin Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 610 615 620 Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 625 630 635 640 Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 645 650 655 Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 660 665 670 Lys Glu Leu Ile Gin Gly Ile Arg Asp Lys Gin Ser Asn Lys Thr Ile 675 680 685 Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 690 695 700 Asn Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 705 710 715 720 Page 2049 of 3790 Ile Lys Lys Ala Gin Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 725 730 735 Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin 740 745 750 Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 755 760 765 Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Arg 770 775 780 Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 785 790 795 800 Lys Asp Phe Gly Ser Gin Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 805 810 815 Ser Leu Gin Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Arg 820 825 830 Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 835 840 845 Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 850 855 860 Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 865 870 875 880 Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 885 890 895 Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 900 905 910 Thr Lys Ile Lys 915 Leu Thr Glu Glu Asp Lys 920 Ala Gly Phe 925 Ile Lys Arg Gin Leu Val 930 Glu Thr Arg Gin 935 Ile Thr Lys His Val Ala 940 Gly Ile Leu His 945 His Arg Phe Asn Lys 950 Ala Glu Asp Thr Asn Glu 955 Pro Ile Arg Lys 960 Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gin Phe Arg Asn 965 975 Page 2050 of 3790 970 Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala 980 985 990 His Asp Ala Tyr Leu Asn Gly Val Val Ala Leu Ala Leu Leu Lys Lys 995 1000 1005 Tyr Pro Gin Leu Ala Pro Glu Phe Val Tyr Gly Glu Tyr Leu Lys 1010 1015 1020 Phe Asn Ala His Lys Ala Asn Lys Ala Thr Val Lys Lys Glu Phe 1025 1030 1035 Tyr Ser Asn Ile Met Lys Phe Phe Glu Ser Asp Thr Pro Val Cys 1040 1045 1050 Asp Glu Asn Gly Glu Ile Phe Trp Asp Lys Ser Lys Ser Ile Ala 1055 1060 1065 Gin Val Lys Lys Val Ile Asn His His His Met Asn Ile Val Lys 1070 1075 1080 Lys Thr Glu Ile Gin Lys Gly Gly Phe Ser Lys Glu Thr Val Glu 1085 1090 1095 Pro Lys Lys Asp Ser Ser Lys Leu Leu Pro Arg Lys Asn Asn Trp 1100 1105 1110 Asp Pro Ala Lys Tyr Gly Gly Leu Gly Ser Pro Asn Val Ala Tyr 1115 1120 1125 Thr Val Ala Phe Thr Tyr Glu Lys Gly Lys Ala Arg Lys Arg Thr 1130 1135 1140 Asn Ala Leu Glu Gly Ile Thr Ile Met Glu Arg Glu Ala Phe Glu 1145 1150 1155 Gin Ser Pro Val Leu Phe Leu Lys Asn Lys Gly Tyr Glu Gin Ala 1160 1165 1170 Glu Ile Glu Met Lys Leu Pro Lys Tyr Ala Leu Phe Glu Leu Glu 1175 1180 1185 Asn Gly Arg Lys Arg Met Val Ala Ser Asn Lys Glu Ala Gin Lys 1190 1195 1200 Page 2051 of 3790 Gly Lys 1340 5 Leu Asp Ile 10 Gly Thr Asn Ser Val 15 Gly Trp Ser Val 20 Leu Thr Asp Asp Tyr Arg Leu Val 25 Ser Lys 30 Lys Met Lys Val Ala 35 Gly Asn Thr Glu Lys 40 Ser Ser Thr Lys Lys Asn Phe 45 Trp Gly Val Arg Leu Phe Asp Glu Gly Gin Thr Ala Glu Ala Arg Arg Ser 50 55 60 Page 2052 of 3790 Lys Arg Thr Ala Arg Arg Arg Leu Ala Arg Arg Arg Gin Arg Ile Leu 65 70 75 80 Glu Leu Gin Lys Ile Phe Ala Pro Glu Ile Leu Lys Ile Asp Glu His 85 90 95 Phe Phe Ala Arg Leu Asn Glu Ser Phe Leu Val Leu Asp Glu Lys Lys 100 105 110 Gin Ser Arg His Pro Val Phe Ala Thr Ile Lys Gin Glu Lys Ser Tyr 115 120 125 His Gin Thr Tyr Pro Thr Ile Tyr His Leu Arg Gin Ala Leu Ala Asp 130 135 140 Ser Ser Glu Lys Ala Asp Ile Arg Leu Val Tyr Leu Ala Met Ala His 145 150 155 160 Leu Leu Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Thr 165 170 175 Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gin Phe Leu Ser Thr Tyr 180 185 190 Asn Gin Gin Phe Ser Glu Ala Asp Asp Lys Gin Thr Glu Lys Leu Asp 195 200 205 Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 210 215 220 Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 225 230 235 240 Gly Tyr Leu Ser Gin Phe Ile Lys Leu Met Val Gly Asn Gin Gly Asn 245 250 255 Phe Lys Asn Val Phe Gly Leu Glu Glu Ala Lys Leu Gin Phe Ser Lys 260 265 270 Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly Asp 275 280 285 Asp Tyr Ile Asp Leu Phe Val Gin Ala Lys Asn Val Tyr Asp Ala Val 290 295 300 Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala Lys 305 310 315 320 Page 2053 of 3790 Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp Leu 325 330 335 Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr Arg 340 345 350 Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile Glu 355 360 365 Gly His Ala Thr Gin Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu Leu 370 375 380 Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gin Glu 385 390 395 400 Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile Pro His 405 410 415 Gin Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gin Lys Lys 420 425 430 His Tyr Pro Phe Leu Lys Glu Glu Gin Glu Lys Leu Glu Ser Leu Leu 435 440 445 Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gin Glu 450 455 460 Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile Lys 465 470 475 480 Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val Arg 485 490 495 Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn Lys 500 505 510 Val Leu Pro Lys Asn Ser Leu Leu Tyr Gin Lys Phe Ser Ile Tyr Asn 515 520 525 Glu Leu Thr Lys Val Arg Tyr Gin Asp Glu Arg Gly Gin Met Asn Tyr 530 535 540 Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu Lys 545 550 555 560 Asn Arg Lys Val Thr Lys Lys Asp Leu Gin Glu Phe Leu Tyr Leu Lys 565 570 575 Page 2054 of 3790 Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe Asn 580 585 590 Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn Lys 595 600 605 Arg Glu Met Lys Gin Trp Leu Glu Asp Pro Glu Leu Ala Ser Met Phe 610 615 620 Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met Ile 625 630 635 640 Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile Ile 645 650 655 Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser Lys 660 665 670 Glu Leu Ile Gin Gly Ile Arg Asp Lys Gin Ser Asn Lys Thr Ile Leu 675 680 685 Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg Asn 690 695 700 Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu Ile 705 710 715 720 Lys Lys Ala Gin Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile Val 725 730 735 Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser 740 745 750 Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro Ala 755 760 765 Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Arg Gly 770 775 780 Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu Lys 785 790 795 800 Asp Phe Gly Ser Gin Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser Ser 805 810 815 Leu Gin Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Arg Asp 820 830 Page 2055 of 3790 825 Page 2056 of 3790 Page 2057 of 3790 Lys Arg Tyr Thr Ser Leu Thr Glu Ile Trp Gin Ser Thr Ile Ile 1310 1315 1320 His Gin Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Arg Met Gly 1325 1330 1335 Lys 951 1340 PRT Enterococcus faecium 951 Page 2058 of 3790 Glu Asn Ser Ser Val Thr Glu Thr Phe Arg Gin Phe Leu Ser Thr Tyr 180 185 190 Asn Gin Gin Phe Ser Glu Ala Asp Asp Lys Gin Thr Glu Lys Leu Asp 195 200 205 Glu Ala Val Asp Cys Ser Phe Val Phe Thr Glu Lys Met Ser Lys Thr 210 215 220 Lys Lys Ala Glu Thr Leu Leu Lys Tyr Phe Pro His Glu Lys Ser Asn 225 230 235 240 Gly Tyr Leu Ser Gin Phe Ile Lys Leu Met Val Gly Asn Gin Gly Asn 245 250 255 Phe Lys Asn Val Phe Gly Leu Glu Glu Glu Ala Lys Leu Gin Phe Ser 260 265 270 Lys Glu Thr Tyr Glu Glu Asp Leu Glu Glu Leu Leu Glu Lys Ile Gly 275 280 285 Asp Asp Tyr Ile Asp Leu Phe Val Gin Ala Lys Asn Val Tyr Asp Ala 290 295 300 Val Leu Leu Ser Glu Ile Leu Ser Asp Ser Thr Lys Asn Thr Arg Ala 305 310 315 320 Lys Leu Ser Ala Gly Met Ile Arg Arg Tyr Asp Ala His Lys Glu Asp 325 330 335 Leu Val Leu Leu Lys Arg Phe Val Lys Glu Asn Leu Pro Lys Lys Tyr 340 345 350 Arg Ala Phe Phe Gly Asp Asn Ser Val Asn Gly Tyr Ala Gly Tyr Ile 355 360 365 Glu Gly His Ala Thr Gin Glu Asp Phe Tyr Lys Phe Val Lys Lys Glu 370 375 380 Leu Thr Gly Ile Arg Gly Ser Glu Val Phe Leu Thr Lys Ile Glu Gin 385 390 395 400 Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile Pro 405 410 415 His Gin Ile His Leu Thr Glu Leu Arg Ala Ile Ile Ala Asn Gin Lys 420 425 430 Page 2059 of 3790 Lys His Tyr Pro Phe Leu Lys Glu Glu Gin Glu Lys Leu Glu Ser Leu 435 440 445 Leu Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gin 450 455 460 Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 465 470 475 480 Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 485 490 495 Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Ile Pro His Asn 500 505 510 Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gin Lys Phe Ser Ile Tyr 515 520 525 Asn Glu Leu Thr Lys Val Arg Tyr Gin Asp Glu Arg Gly Gin Met Asn 530 535 540 Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 545 550 555 560 Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gin Glu Phe Leu Tyr Leu 565 570 575 Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 580 585 590 Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 595 600 605 Lys Arg Glu Met Lys Gin Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 610 615 620 Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 625 630 635 640 Ile Lys Thr Arg Leu Ser His His Glu Ala Thr Leu Gly Lys His Ile 645 650 655 Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 660 665 670 Lys Glu Leu Ile Gin Gly Ile Arg Asp Lys Gin Ser Asn Lys Thr Ile Page 2060 of 3790 675 680 685 Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 690 695 700 Asn Cys Met Gin Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 705 710 715 720 Ile Lys Lys Ala Gin Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 725 730 735 Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin 740 745 750 Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 755 760 765 Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Arg 770 775 780 Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 785 790 795 800 Lys Asp Phe Gly Ser Gin Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 805 810 815 Ser Leu Gin Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Arg 820 825 830 Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 835 840 845 Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 850 855 860 Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 865 870 875 880 Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 885 890 895 Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 900 905 910 Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 915 920 925 Page 2061 of 3790 Page 2062 of 3790 Gly Lys 1340 952 892 PRT Enterococcus faecium 952 Met Thr Phe Lys Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Lys Gin 15 10 15 Glu Asn Ser Pro Phe Ala Trp Leu Ile Arg Lys Ser Glu Glu Lys Ile 20 25 30 Page 2063 of 3790 Lys Pro Trp Asn Leu Pro Glu Ile Val Asp Met Glu Gly Ser Ala Val 35 40 45 Arg Phe Ile Glu Arg Met Ile Asn Thr Asp Met Tyr Met Pro His Asn 50 55 60 Lys Val Leu Pro Lys Asn Ser Leu Leu Tyr Gin Lys Phe Ser Ile Tyr 65 70 75 80 Asn Glu Leu Thr Lys Val Arg Tyr Gin Asp Glu Arg Gly Gin Met Asn 85 90 95 Tyr Phe Ser Ser Ile Glu Lys Lys Glu Ile Phe His Glu Leu Phe Glu 100 105 110 Lys Asn Arg Lys Val Thr Lys Lys Asp Leu Gin Glu Phe Leu Tyr Leu 115 120 125 Lys Tyr Asp Ile Lys His Ala Glu Leu Ser Gly Ile Glu Lys Ala Phe 130 135 140 Asn Ala Ser Tyr Thr Thr Tyr His Asp Phe Leu Thr Met Ser Glu Asn 145 150 155 160 Lys Arg Glu Met Glu Gin Trp Leu Glu Asp Pro Glu Leu Ala Ser Met 165 170 175 Phe Glu Glu Ile Ile Lys Thr Leu Thr Val Phe Glu Asp Arg Glu Met 180 185 190 Ile Lys Thr Arg Leu Ser His His Lys Ala Thr Leu Gly Lys His Ile 195 200 205 Ile Lys Lys Leu Thr Lys Lys His Tyr Thr Gly Trp Gly Arg Leu Ser 210 215 220 Lys Glu Leu Ile Gin Gly Ile Arg Asp Lys Gin Ser Asn Lys Thr Ile 225 230 235 240 Leu Asp Tyr Leu Ile Asn Asp Asp Asp Phe Pro His His Arg Asn Arg 245 250 255 Asn Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Ser Phe Lys Lys Glu 260 265 270 Ile Lys Lys Ala Gin Met Ile Thr Asp Thr Glu Asn Leu Glu Glu Ile 275 280 285 Page 2064 of 3790 Val Lys Glu Leu Thr Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin 290 295 300 Ser Leu Lys Ile Val Asp Glu Ile Val Gly Ile Met Gly Tyr Glu Pro 305 310 315 320 Ala Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Arg 325 330 335 Gly Leu Lys Ser Ser Arg Pro Arg Leu Lys Ala Leu Glu Glu Ser Leu 340 345 350 Lys Asp Phe Gly Ser Gin Leu Leu Lys Glu Tyr Pro Thr Asp Asn Ser 355 360 365 Ser Leu Gin Lys Asp Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Arg 370 375 380 Asp Met Tyr Thr Gly Ala Pro Leu Asp Ile His Arg Leu Ser Asp Tyr 385 390 395 400 Asp Ile Asp His Ile Ile Pro Arg Ser Phe Thr Thr Asp Asn Ser Ile 405 410 415 Asp Asn Lys Val Leu Val Ser Ser Lys Glu Asn Arg Leu Lys Lys Asp 420 425 430 Asp Val Pro Ser Glu Lys Val Val Lys Lys Met Arg Ser Phe Trp Tyr 435 440 445 Asp Leu Tyr Ser Ser Lys Leu Ile Ser Lys Arg Lys Leu Asp Asn Leu 450 455 460 Thr Lys Ile Lys Leu Thr Glu Glu Asp Lys Ala Gly Phe Ile Lys Arg 465 470 475 480 Gin Leu Val Glu Thr Arg Gin Ile Thr Lys His Val Ala Gly Ile Leu 485 490 495 His His Arg Phe Asn Lys Ala Glu Asp Thr Asn Glu Pro Ile Arg Lys 500 505 510 Val Arg Ile Ile Thr Leu Lys Ser Ala Leu Val Ser Gin Phe Arg Asn 515 520 525 Arg Phe Gly Ile Tyr Lys Val Arg Glu Ile Asn Glu Tyr His His Ala Page 2066 of 3790 Page 2067 of 3790 Tyr Lys Pro Ala Ser Ile Phe Pro Thr Leu Glu Glu Glu Lys Glu Tyr 115 120 125 Tyr Gin Lys Tyr Pro Thr Ile Tyr His Leu Arg Gin Lys Leu Val Asp 130 135 140 Ser Thr Glu Lys Glu Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Leu Leu Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Asp Thr 165 170 175 Glu Asn Thr Ser Ile Glu Glu Ser Phe Arg Val Phe Leu Glu Gin Tyr 180 185 190 Ser Lys Gin Ser Asp Gin Pro Leu Ile Val His Gin Pro Val Leu Thr 195 200 205 Ile Leu Thr Asp Lys Leu Ser Lys Thr Lys Lys Val Glu Glu Ile Leu 210 215 220 Lys Tyr Tyr Pro Thr Glu Lys Ile Asn Ser Phe Phe Ala Gin Cys Leu 225 230 235 240 Lys Leu Ile Val Gly Asn Gin Ala Asn Phe Lys Arg Ile Phe Asp Leu 245 250 255 Glu Ala Glu Val Lys Leu Gin Phe Ser Lys Glu Thr Tyr Glu Glu Asp 260 265 270 Leu Glu Ser Leu Leu Glu Lys Ile Gly Asp Glu Tyr Leu Asp Ile Phe 275 280 285 Leu Gin Ala Lys Lys Val His Asp Ala Ile Leu Leu Ser Glu Ile Ile 290 295 300 Ser Ser Thr Val Lys His Thr Lys Ala Lys Leu Ser Ser Gly Met Val 305 310 315 320 Glu Arg Tyr Glu Arg His Lys Ala Asp Leu Ala Lys Phe Lys Gin Phe 325 330 335 Val Lys Glu Asn Val Pro Gin Lys Ala Thr Val Phe Phe Lys Asp Thr 340 345 350 Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Lys Gly Lys Thr Thr Gin Glu 355 360 365 Page 2068 of 3790 Glu Phe Tyr Lys Phe Val Lys Lys Glu Leu Ser Gly Val Val Gly Ser 370 375 380 Glu Pro Phe Leu Glu Lys Ile Asp Gin Glu Thr Phe Leu Leu Lys Gin 385 390 395 400 Arg Thr Tyr Thr Asn Gly Val Ile Pro His Gin Val His Leu Ile Glu 405 410 415 Leu Lys Ala Ile Ile Asp Gin Gin Lys Gin His Tyr Pro Phe Leu Glu 420 425 430 Glu Ala Gly Pro Lys Ile Ile Ala Leu Phe Lys Phe Arg Ile Pro Tyr 435 440 445 Tyr Val Gly Pro Leu Ala Lys Glu Gin Glu Ala Ser Ser Phe Ala Trp 450 455 460 Ile Glu Arg Lys Thr Ala Glu Lys Ile Asn Pro Trp Asn Phe Ser Glu 465 470 475 480 Val Val Asp Ile Glu Lys Ser Ala Met Arg Phe Ile Gin Arg Met Thr 485 490 495 Lys Gin Asp Thr Tyr Leu Pro Thr Glu Lys Val Leu Pro Lys Asn Ser 500 505 510 Leu Leu Tyr Gin Lys Tyr Met Ile Phe Asn Glu Leu Thr Lys Val Ser 515 520 525 Tyr Lys Asp Glu Arg Gly Val Lys Gin Tyr Phe Ser Gly Asp Glu Lys 530 535 540 Gin Gin Ile Phe Lys Gin Leu Phe Gin Lys Glu Arg Gly Lys Ile Thr 545 550 555 560 Val Lys Lys Leu Gin Asn Phe Leu Tyr Thr His Tyr His Ile Glu Asn 565 570 575 Ala Gin Ile Phe Gly Ile Glu Lys Ala Phe Asn Ala Ser Tyr Ser Thr 580 585 590 Tyr His Asp Phe Met Lys Leu Ala Lys Thr Asn Gin Lys Ala Met Gin 595 600 605 Glu Trp Leu Glu Gin Pro Glu Met Glu Pro Ile Phe Glu Asp Ile Val 610 615 620 Page 2069 of 3790 Lys Ile Leu Thr Ile Phe Glu Asp Arg Gin Met Ile Lys His Gin Leu 625 630 635 640 Ser Lys Tyr Gin Glu Val Phe Gly Glu Lys Leu Leu Lys Glu Phe Ala 645 650 655 Arg Lys His Tyr Thr Gly Trp Gly Arg Phe Ser Ala Lys Leu Ile His 660 665 670 Gly Ile Arg Asp Arg Lys Thr Asn Lys Thr Ile Leu Asp Tyr Leu Ile 675 680 685 Asn Asp Asp Asp Val Pro Ala Asn Arg Asn Arg Asn Leu Met Gin Leu 690 695 700 Ile Asn Asp Glu His Leu Ser Phe Lys Glu Glu Ile Ala Lys Ala Thr 705 710 715 720 Val Phe Ser Lys His Lys Ser Leu Val Asp Val Ile Gin Asp Leu Pro 725 730 735 Gly Ser Pro Ala Ile Lys Lys Gly Ile Trp Gin Ser Leu Lys Ile Val 740 745 750 Glu Glu Leu Ile Ala Ile Ile Gly Tyr Lys Pro Lys Asn Ile Val Ile 755 760 765 Glu Met Ala Arg Glu Asn Gin Lys Thr His Arg Thr Ser Pro Arg Leu 770 775 780 Lys Ala Leu Glu Asn Gly Leu Lys Gin Ile Gly Ser Thr Leu Leu Lys 785 790 795 800 Glu Gin Pro Thr Asp Asn Lys Ala Leu Gin Lys Glu Arg Leu Tyr Leu 805 810 815 Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Pro Leu Glu 820 825 830 Ile Glu Asn Leu His Gin Tyr Glu Val Asp His Ile Ile Pro Arg Ser 835 840 845 Phe Ile Val Asp Asn Ser Ile Asp Asn Lys Val Leu Val Ala Ser Lys 850 855 860 Gin Asn Gin Lys Lys Arg Asp Asp Val Pro Lys Lys Gin Ile Val Asn 880 865 870 Page 2070 of 3790 875 Arg Lys Asn Asn Trp Asp Val Thr Lys Tyr Gly Gly Phe Gly Ser 1100 1105 1110 Page 2071 of 3790 954 116 PRT Page 2072 of 3790 Enterococcus sp. 954 Page 2073 of 3790 Lys Val Asp Pro Asn Phe Phe Ile Arg Leu Glu Glu Ser Lys Phe Phe 85 90 95 Leu Asp Asp Arg Ser Glu Asn Asn Arg Gin Arg Tyr Thr Leu Phe Asn 100 105 110 Asp Ala Lys Phe Thr Asp Lys Asp Tyr Tyr Glu Lys Tyr Lys Thr Ile 115 120 125 Phe His Leu Arg Ser Ala Leu Ile Asn Ser Asp Glu Lys Phe Asp Val 130 135 140 Arg Leu Val Phe Leu Ala Ile Leu Asn Leu Phe Ser His Arg Gly His 145 150 155 160 Phe Leu Asn Ala Ser Leu Lys Gly Asp Gly Glu Ile Gin Gly Val Asp 165 170 175 Ile Phe Tyr Asn Asp Leu Tyr Glu Val Cys Glu Glu Phe Glu Ile Asp 180 185 190 Leu Pro Gin Ile Ser Asn Ile Asp Asn Phe Glu Lys Ile Leu Ser Gin 195 200 205 Lys Gly Lys Ser Arg Thr Lys Ile Leu Glu Glu Leu Ser Glu Glu Leu 210 215 220 Ser Ile Ser Lys Lys Glu Lys Ile Lys Tyr Ser Leu Leu Lys Leu Ile 225 230 235 240 Cys Gly Met Lys Ile Lys Val Val Asp Ile Tyr Ala Asp Glu Asp Ile 245 250 255 Gin Glu Asp Asp Lys Lys Lys Asp Leu Gly Phe Arg Glu Ser Asp Tyr 260 265 270 Glu Lys Ser Ser Leu Glu Val Lys Glu Ile Ile Gly Asp Asp His Phe 275 280 285 Glu Leu Ile Glu Arg Ala Lys Ala Val His Asp Ile Gly Leu Leu Ala 290 295 300 Asn Ile Ile Gly Asn Ser Lys Tyr Leu Cys Glu Ala Arg Val Glu Ala 305 310 315 320 Tyr Asp Asn His His Lys Asp Leu Gin Lys Ile Lys Glu Leu Leu Lys 325 330 335 Page 2074 of 3790 Lys Tyr Asp Ile Lys Ala Tyr Thr Asp Met Phe Arg Lys Met Thr Asp 340 345 350 Lys Asn Tyr Ser Ala Tyr Val Gly Ser Val Asn Ser Asn Ile Ala Lys 355 360 365 Glu Arg Arg Ser Val Asp Asn Arg Lys Ile Glu Asp Leu Tyr Glu Tyr 370 375 380 Ile Lys Lys Ile Ala Leu Lys Asn Ile Ser Asp Asp Asn Glu Asp Lys 385 390 395 400 Ile Glu Ile Leu Lys Lys Ile Glu Thr Gly Glu Phe Leu Lys Lys Gin 405 410 415 Leu Thr Ala Ser Asn Gly Val Ile Pro Asn Gin Leu Gin Ser Arg Glu 420 425 430 Leu Arg Ala Ile Leu Lys Lys Ala Glu Asn Tyr Leu Pro Phe Leu Lys 435 440 445 Glu Lys Gly Glu Lys Asn Leu Thr Val Ser Glu Met Ile Ile Gin Leu 450 455 460 Phe Glu Phe Gin Ile Pro Tyr Tyr Val Gly Pro Leu Asp Lys Asn Pro 465 470 475 480 Lys Lys Asp Lys Asn Ala Asn Ser Trp Ala Val Ile Pro Ser Gly Gly 485 490 495 Arg Ile Leu Pro Trp Asn Phe Glu Asp Lys Val Asp Val Lys Gly Ser 500 505 510 Arg Lys Glu Phe Ile Glu Lys Met Val Arg Lys Cys Thr Tyr Leu Ser 515 520 525 Glu Glu His Thr Leu Pro Lys Gin Ser Leu Leu Tyr Glu Lys Phe Met 530 535 540 Val Leu Asn Glu Ile Asn Asn Ile Lys Ile Asp Gly Glu Lys Ile Ser 545 550 555 560 Val Glu Ala Lys Gin Lys Ile Tyr Asn Asp Leu Phe Met Lys Gly Lys 565 570 575 Lys Val Ser Gin Lys Ala Ile Lys Gin Glu Leu Ile Ser Leu Asn Ile 580 585 590 Page 2075 of 3790 Met Ser Lys Asp Ser Val Leu Ser Gly Ile Asp Thr Val Cys Asn Ala 595 600 605 Tyr Leu Ser Ser Ile Ala Lys Phe Arg Gly Val Phe Asp Glu Asn Val 610 615 620 Asn Asn Gin Ser Thr Ile Asp Met Ile Glu Asp Ile Ile Phe Leu Lys 625 630 635 640 Thr Val Tyr Ser Asp Glu Lys Arg Phe Val Lys Glu Glu Ile Val Glu 645 650 655 Lys Tyr Gly Asp Glu Ile Asp Lys Asp Lys Ile Lys Arg Ile Leu Gly 660 665 670 Phe Lys Phe Ser Asn Trp Gly Asn Ile Ser Lys Ser Phe Leu Glu Leu 675 680 685 Glu Gly Ala Asp Val Gly Thr Gly Glu Ile Arg Ser Ile Ile Gin Ser 690 695 700 Leu Trp Glu Thr Asn Phe Asn Leu Met Glu Leu Leu Ser Ser Arg Phe 705 710 715 720 Thr Tyr Met Asp Glu Leu Glu Lys Arg Val Lys Lys Leu Glu Lys Pro 725 730 735 Leu Ser Glu Trp Thr Ile Glu Asp Leu Asp Asp Met Tyr Leu Ser Ser 740 745 750 Pro Val Lys Arg Met Ile Trp Gin Ser Met Lys Ile Val Asp Glu Ile 755 760 765 Gin Thr Val Ile Gly Tyr Ala Pro Lys Arg Ile Phe Val Glu Met Thr 770 775 780 Arg Ser Glu Gly Glu Lys Val Arg Thr Lys Ser Arg Lys Asp Arg Leu 785 790 795 800 Lys Glu Leu Tyr Ser Ala Ile Lys Glu Asp Ser Lys Gin Trp Val Lys 805 810 815 Glu Leu Asp Ala Lys Asp Glu Ser Tyr Phe Arg Ser Lys Lys Met Tyr 820 825 830 Leu Tyr Tyr Leu Gin Lys Gly Arg Cys Met Tyr Ser Gly Glu Val Ile Page 2076 of 3790 Lys Thr Met Ser Lys Asn Ser Pro Leu Ile Thr Lys Lys Val Glu 1070 1075 1080 Page 2078 of 3790 956 1391 PRT Eubacterium yurii 956 Met Glu Asn Lys Gin Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn Ser 15 10 15 Val Gly Trp Ala Val Thr Asp Thr Ser Tyr Asn Leu Leu Arg Ala Lys 20 25 30 Gly Lys Asp Met Trp Gly Ala Arg Leu Phe Glu Lys Ala Asn Thr Ala 35 40 45 Ala Glu Arg Arg Thr Lys Arg Thr Ser Arg Arg Arg Ser Glu Arg Glu 50 55 60 Lys Ala Arg Lys Ala Met Leu Lys Glu Leu Phe Ala Asp Glu Ile Asn 65 70 75 80 Arg Val Asp Pro Ser Phe Phe Ile Arg Leu Glu Glu Ser Lys Phe Phe 85 90 95 Leu Asp Asp Arg Ser Glu Asn Asn Arg Gin Arg Tyr Thr Leu Phe Asn 100 105 110 Asp Ala Thr Phe Thr Asp Lys Asp Tyr Tyr Glu Lys Tyr Lys Thr Ile 115 120 125 Phe His Leu Arg Ser Ala Leu Ile Asn Ser Asp Glu Lys Phe Asp Val 130 135 140 Page 2079 of 3790 Arg Leu Val Phe Leu Ala Ile Leu Asn Leu Phe Ser His Arg Gly His 145 150 155 160 Phe Leu Asn Ala Ser Leu Lys Gly Asp Gly Asp Ile Gin Gly Met Asp 165 170 175 Val Phe Tyr Asn Asp Leu Val Glu Ser Cys Glu Tyr Phe Glu Ile Glu 180 185 190 Leu Pro Arg Ile Thr Asn Ile Asp Asn Phe Glu Lys Ile Leu Ser Gin 195 200 205 Lys Gly Lys Ser Arg Thr Lys Ile Leu Glu Glu Leu Ser Glu Glu Leu 210 215 220 Ser Ile Ser Lys Lys Asp Lys Ser Lys Tyr Asn Leu Ile Lys Leu Ile 225 230 235 240 Ser Gly Leu Glu Ala Ser Val Val Glu Leu Tyr Asn Ile Glu Asp Ile 245 250 255 Gin Asp Glu Asn Lys Lys Ile Lys Ile Gly Phe Arg Glu Ser Asp Tyr 260 265 270 Glu Glu Ser Ser Leu Lys Val Lys Glu Ile Ile Gly Asp Glu Tyr Phe 275 280 285 Asp Leu Val Glu Arg Ala Lys Ser Val His Asp Met Gly Leu Leu Ser 290 295 300 Asn Ile Ile Gly Asn Ser Lys Tyr Leu Cys Glu Ala Arg Val Glu Ala 305 310 315 320 Tyr Glu Asn His His Lys Asp Leu Leu Lys Ile Lys Glu Leu Leu Lys 325 330 335 Lys Tyr Asp Lys Lys Ala Tyr Asn Asp Met Phe Arg Lys Met Thr Asp 340 345 350 Lys Asn Tyr Ser Ala Tyr Val Gly Ser Val Asn Ser Asn Ile Ala Lys 355 360 365 Glu Arg Arg Ser Val Asp Lys Arg Lys Ile Glu Asp Leu Tyr Lys Tyr 370 375 380 Ile Glu Asp Thr Ala Leu Lys Asn Ile Pro Asp Asp Asn Lys Asp Lys 385 390 395 400 Page 2080 of 3790 Ile Glu Ile Leu Glu Lys Ile Lys Leu Gly Glu Phe Leu Lys Lys Gin 405 410 415 Leu Thr Ala Ser Asn Gly Val Ile Pro Asn Gin Leu Gin Ser Arg Glu 420 425 430 Leu Arg Ala Ile Leu Lys Lys Ala Glu Asn Tyr Leu Pro Phe Leu Lys 435 440 445 Glu Lys Gly Glu Lys Asn Leu Thr Val Ser Glu Met Ile Ile Gin Leu 450 455 460 Phe Glu Phe Gin Ile Pro Tyr Tyr Val Gly Pro Leu Asp Lys Asn Pro 465 470 475 480 Lys Lys Asp Asn Lys Ala Asn Ser Trp Ala Lys Ile Lys Gin Gly Gly 485 490 495 Arg Ile Leu Pro Trp Asn Phe Glu Asp Lys Val Asp Val Lys Gly Ser 500 505 510 Arg Lys Glu Phe Ile Glu Lys Met Val Arg Lys Cys Thr Tyr Ile Ser 515 520 525 Asp Glu His Thr Leu Pro Lys Gin Ser Leu Leu Tyr Glu Lys Phe Met 530 535 540 Val Leu Asn Glu Ile Asn Asn Ile Lys Ile Asp Gly Glu Lys Ile Ser 545 550 555 560 Val Glu Ala Lys Gin Lys Ile Tyr Asn Asp Leu Phe Val Lys Gly Lys 565 570 575 Lys Val Ser Gin Lys Asp Ile Lys Lys Glu Leu Ile Ser Leu Asn Ile 580 585 590 Met Asp Lys Asp Ser Val Leu Ser Gly Thr Asp Thr Val Cys Asn Ala 595 600 605 Tyr Leu Ser Ser Ile Gly Lys Phe Thr Gly Val Phe Lys Glu Glu Ile 610 615 620 Asn Lys Gin Ser Ile Val Asp Met Ile Glu Asp Ile Ile Phe Leu Lys 625 630 635 640 Thr Val Tyr Gly Asp Glu Lys Arg Phe Val Lys Glu Glu Ile Val Glu Page 2082 of 3790 Page 2083 of 3790 Page 2084 of 3790 Cys Glu Lys Asp Leu Met Thr Ile 1385 1390 957 1142 PRT Facklamia hominis 957 Met Tyr Ser Val Gly Leu Asp Ile 1 5 Gly Ile Ala Ser Cys Gly Tyr Ser 10 15 Ile Ile Asn Asp Val Asn Gly Asn 20 Ile Val Glu Leu Gly Thr Leu Leu 25 30 Phe Lys Ser Arg Asn Ser Asp Asn 35 40 Asn Glu Glu Arg Arg Thr Asn Arg 45 Gly Ser Arg Arg Leu Ile Asn Arg 50 55 Arg Arg Thr Arg Leu Asp Asp Gly 60 Lys Lys Leu Leu Ala Glu Lys Gly 65 70 Phe Lys Gin Asp Ser Lys Leu Lys 75 80 His Val Cys Pro Tyr Glu Leu Arg 85 Val Lys Gly Leu His Glu Lys Leu 90 95 Thr Gin Gly Glu Ile Tyr Lys Val 100 Val Leu His Ile Leu Lys Lys Arg 105 110 Gly Ile Ser Tyr Leu Asp Glu Ser 115 120 Asp Glu Asn Ser Ser Gly Ile Asp 125 Gly Ala Ser Tyr Lys Asp Gin Val 130 135 Asn Leu Asn Leu Asn Leu Gin Lys 140 Glu Leu Thr Pro Gly Gin Ile Gin 145 150 Leu Lys Arg Leu Lys Glu Asn Gly 155 160 Arg Ile Lys Ser Gly Val Thr Phe 165 Glu Asn Gly Tyr Gin Leu Asn Val 170 175 Phe Ser Val Ser Ala 180 Tyr Ala Asn Glu 185 Leu Asn Lys Ile Leu 190 Thr Lys Gin Ser Glu Tyr Tyr Ser Glu Ile Asp Gin Ile Trp Ile Asp Arg Phe 195 200 205 Page 2085 of 3790 Thr Lys Asn Gly Tyr Arg Lys Glu Ala Gly Leu Val Tyr Arg Lys Arg 210 215 220 Pro Tyr Tyr Asp Gly Pro Gly Asn Glu Lys Asn Asn Ser Ile Tyr Gly 225 230 235 240 Arg Trp Ala Asn Phe Lys Glu Asp Gly His Pro Lys Glu Asn Ile Phe 245 250 255 Asp Gin Leu Ile Gly Leu Asp Ser Val Asp Ser Thr Gin Val Arg Ala 260 265 270 Ser Ala Ser Thr Leu Thr Ala Gin Lys Tyr Asn Leu Leu Asn Asp Leu 275 280 285 Asn Asn Leu Thr Ile Ile Glu Asp Asp Arg Lys Phe Thr Thr Asp Glu 290 295 300 Lys Val Ser Ile Ile Asn Tyr Leu Met Thr Gin Asp Ile Thr Arg Phe 305 310 315 320 Gly Pro Lys Glu Leu Ala Lys Phe Tyr Gin Leu Glu Val Asp Gin Ile 325 330 335 Arg Gly Trp Arg Ile Asp Asn Lys Gly Asn Pro Glu Ile His Ser Leu 340 345 350 Lys Val Tyr Arg Asp Trp Lys Lys Ile Phe Asn Thr Ser Ser Ile Asp 355 360 365 Leu Thr Ser Ile Gin Thr Trp Val Val Asp Glu Leu Ala Asn Val Ile 370 375 380 Thr Leu Asn Thr Glu Ile Pro Ser Thr Leu Ala Thr Leu Lys Ile Lys 385 390 395 400 Ile Pro Asp Ile Asp Gin Gin Ile Leu Asn Phe Val Glu Asn Asn Phe 405 410 415 Tyr Glu Leu Lys Lys Lys Thr Ser Lys Asn Ser Trp His Ser Phe Ser 420 425 430 Leu Lys Thr Leu Asn Ile Leu Ile Pro Glu Leu Leu Asn Thr Ser Glu 435 440 445 Glu Gin Asn Thr Ile Leu Glu Arg Leu Asn Leu Lys Phe Asp Leu Lys Page 2087 of 3790 Phe Phe Tyr Lys Gin Lys Asp Leu Thr Lys Val Lys Val Val Asn Gly 705 710 715 720 Ser Phe Thr His Thr Leu Arg Lys Lys Trp Gly Ser Ser Leu Asp Lys 725 730 735 Asn Arg Asp Thr Tyr His His His Ala Val Asp Ala Thr Leu Cys Ala 740 745 750 Val Thr Pro Phe Ile Asn Ile Val Lys Tyr Glu Phe Phe Glu Glu Asp 755 760 765 Gly Ile Lys Tyr Met Val Asp Leu Thr Thr Gly Glu Lys Val Ala Tyr 770 775 780 Ser Asp Tyr Lys Lys Met Lys Phe Tyr Asp Lys Arg Ala Tyr Val Pro 785 790 795 800 Ile Trp Asp Gly Phe Ile Lys Gin Leu Thr Pro Ala Asn Leu Tyr Pro 805 810 815 Lys Ile Lys Phe Ser His Gin Val Asp Ser Lys Trp Asn Arg Lys Ile 820 825 830 Ser Asp Ala Thr Ile Tyr Ser Thr Arg Lys Ile Val Glu Thr Lys Ile 835 840 845 Asn Lys Lys Gly Val Ala Lys Glu Thr Val Lys Asp Ile Val Ile Asp 850 855 860 Lys Ile Lys Asp Ile Tyr Thr Pro Glu Gly Trp Arg Lys Phe Lys Glu 865 870 875 880 Lys Gin Asp Lys Leu Leu Met Lys Asn Phe Asp Glu Lys Thr Tyr Asn 885 890 895 Lys Leu Ile Lys Ile Ala Lys Glu Tyr Pro Glu Lys Lys Glu Val Gin 900 905 910 Thr Ser Asn Gly Lys Val Ser Leu Val Glu Val Ser Pro Phe Lys Met 915 920 925 Tyr Cys Glu Glu Gin Asn Val Pro Ala Ile Arg Lys Tyr Ser Lys Lys 930 935 940 Gly Asn Gly Pro Tyr Ile Arg Ser Leu Lys Phe Tyr Asp Lys Glu Leu 945 950 955 960 Page 2088 of 3790 958 1347 PRT Finegoldia magna 958 Met Lys Ser Glu Lys Lys Tyr Tyr Ile Gly Leu Asp Val Gly Thr Asn 15 10 15 Ser Val Gly Trp Ala Val Thr Asp Glu Phe Tyr Asn Ile Leu Arg Ala 20 25 30 Page 2089 of 3790 Lys Gly Lys Asp Leu Trp Gly Val Arg Leu Phe Glu Lys Ala Lys Thr 35 40 45 Ala Ala Asp Thr Arg Thr Phe Arg Ser Gly Arg Arg Arg Asn Asp Arg 50 55 60 Lys Gly Met Arg Leu Gin Ile Leu Arg Glu Ile Phe Glu Asp Glu Ile 65 70 75 80 Lys Lys Val Asp Lys Asp Phe Tyr Asp Arg Leu Asp Glu Ser Lys Phe 85 90 95 Trp Ala Glu Asp Lys Lys Val Ser Gly Lys Tyr Ser Leu Phe Asn Asp 100 105 110 Lys Asn Phe Ser Asp Lys Gin Tyr Phe Glu Lys Phe Pro Thr Ile Phe 115 120 125 His Leu Arg Lys Tyr Leu Met Glu Glu His Gly Lys Val Asp Ile Arg 130 135 140 Tyr Tyr Phe Leu Ala Ile Asn Gin Met Met Lys Arg Arg Gly His Phe 145 150 155 160 Leu Ile Asp Gly Gin Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 165 170 175 Glu Gin Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 180 185 190 Glu Glu Leu Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 195 200 205 Lys Arg Thr Asp Lys Lys Asn Asn Leu Lys Glu Leu Ile Lys Gly Gin 210 215 220 Asp Phe Asn Lys Gin Glu Gly Asn Ile Leu Asn Ser Ile Phe Glu Ser 225 230 235 240 Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 245 250 255 Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 260 265 270 Gly Asp Ser Tyr Glu Glu Asn Leu Gin Tyr Phe Glu Glu Val Leu Gin 275 280 285 Page 2090 of 3790 Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Thr Tyr Asp Phe Val 290 295 300 Ile Leu Gin Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gin 305 310 315 320 Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 325 330 335 Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gin Val Phe 340 345 350 Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 355 360 365 Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 370 375 380 Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gin Cys Asp Cys Glu 385 390 395 400 Asp Glu Ala Val Lys Tyr Leu Leu Gly Lys Ile Glu Gin Glu Asn Phe 405 410 415 Leu Leu Lys Gin Ile Ser Ser Ile Asn Ser Val Ile Pro His Gin Ile 420 425 430 His Leu Phe Glu Leu Asp Lys Ile Leu Glu Asn Leu Ala Lys Asn Tyr 435 440 445 Pro Ser Phe Asn Asn Lys Lys Glu Glu Phe Thr Lys Ile Glu Lys Ile 450 455 460 Arg Lys Thr Phe Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 465 470 475 480 Asp Tyr His Lys Asn Asn Gly Gly Asn Ala Trp Ile Phe Arg Asn Lys 485 490 495 Gly Glu Lys Ile Arg Pro Trp Asn Phe Glu Lys Ile Val Asp Leu His 500 505 510 Lys Ser Glu Glu Glu Phe Ile Lys Arg Met Leu Asn Gin Cys Thr Tyr 515 520 525 Leu Pro Glu Glu Thr Val Leu Pro Lys Ser Ser Ile Leu Tyr Ser Glu Page 2092 of 3790 Page 2093 of 3790 Page 2094 of 3790 959 1348 PRT Finegoldia magna 959 Page 2095 of 3790 Tyr Tyr Phe Leu Ala Ile Asn Gin Met Met Lys Arg Arg Gly His Phe 145 150 155 160 Leu Ile Asp Gly Gin Ile Ser His Val Thr Asp Asp Lys Pro Leu Lys 165 170 175 Gin Gin Leu Ile Leu Leu Ile Asn Asp Leu Leu Lys Ile Glu Leu Glu 180 185 190 Glu Glu Phe Met Asp Ser Ile Phe Glu Ile Leu Ala Asp Val Asn Glu 195 200 205 Lys Lys Thr Glu Lys Lys Asn Ile Leu Lys Glu Leu Ile Asn Ala Gin 210 215 220 Asp Phe Asn Lys Gin Glu Gly Lys Ile Leu Tyr Ser Ile Phe Glu Ser 225 230 235 240 Ile Val Thr Gly Lys Ala Lys Ile Lys Asn Ile Ile Ser Asp Glu Asp 245 250 255 Ile Leu Glu Lys Ile Lys Glu Asp Asn Lys Glu Asp Phe Val Leu Thr 260 265 270 Gly Asp Ser Tyr Glu Glu Asn Leu Gin Tyr Phe Glu Glu Val Leu Gin 275 280 285 Glu Asn Ile Thr Leu Phe Asn Thr Leu Lys Ser Ala Tyr Asp Phe Val 290 295 300 Ile Leu Gin Ser Ile Leu Lys Gly Lys Ser Thr Leu Ser Asp Ala Gin 305 310 315 320 Val Glu Arg Tyr Asp Glu His Lys Lys Asp Leu Glu Ile Leu Lys Lys 325 330 335 Val Ile Lys Lys Tyr Asp Glu Asp Gly Lys Leu Phe Lys Gin Val Phe 340 345 350 Lys Glu Asp Asn Gly Asn Gly Tyr Val Ser Tyr Ile Gly Tyr Tyr Leu 355 360 365 Asn Lys Asn Lys Lys Ile Thr Ala Lys Lys Lys Ile Ser Asn Ile Glu 370 375 380 Phe Thr Lys Tyr Val Lys Gly Ile Leu Glu Lys Gin Cys Asp Cys Glu Page 2097 of 3790 Ile His Thr Gly Asn Lys Lys Leu Leu Lys Lys Tyr Ile Glu Glu Thr 645 650 655 Tyr Pro Asp Leu Ser Ser Ser Gin Ile Gin Lys Ile Ile Asn Leu Lys 660 665 670 Tyr Lys Asp Trp Gly Arg Leu Ser Arg Lys Leu Leu Asp Gly Ile Thr 675 680 685 Gly Thr Asn Ile Glu Thr Gly Glu Ile Asp Thr Val Ile Asn Phe Leu 690 695 700 Arg Asn Ser Ser Asp Asn Leu Met Gin Ile Ile Gly Ser Gin Asn Tyr 705 710 715 720 Ser Phe Asn Asn Asp Ile Asp Lys Leu Arg Lys Lys Tyr Ile Pro Gin 725 730 735 Glu Ile Ser Tyr Glu Val Val Glu Asn Leu Tyr Val Ser Pro Ser Val 740 745 750 Lys Lys Met Ile Trp Gin Val Ile Arg Ile Thr Glu Glu Ile Thr Lys 755 760 765 Val Met Gly Tyr Asp Pro Asp Lys Ile Phe Ile Glu Met Ala Lys Ser 770 775 780 Glu Glu Gly Lys Lys Thr Thr Ile Ser Arg Lys Asn Lys Leu Leu Ala 785 790 795 800 Leu Tyr Lys Ala Ile Lys Lys Asp Glu Arg Asp Ser Gin Tyr Glu Lys 805 810 815 Leu Leu Thr Gly Leu Asn Lys Leu Asp Asp Ser Asp Leu Arg Ser Arg 820 825 830 Lys Leu Tyr Leu Tyr Tyr Thr Gin Met Gly Arg Asp Met Tyr Thr Gly 835 840 845 Glu Lys Ile Asp Leu Asp Lys Leu Phe Asp Ser Thr His Tyr Asp Lys 850 855 860 Asp His Ile Ile Pro Gin Ser Met Lys Lys Asp Asp Ser Ile Ile Asn 865 870 875 880 Asn Leu Val Leu Val Asn Lys Asn Ala Asn Gin Thr Thr Lys Gly Asn 885 890 895 Page 2098 of 3790 Phe Phe Phe Leu Val Glu His Thr Lys Ser Lys Lys Arg Ile Arg 1130 1135 1140 Page 2099 of 3790 960 1516 PRT Flavobacteriaceae bacterium Page 2100 of 3790 960 Met Leu Lys Gin Gin Lys Asp Lys Ile Ile Gly Met Asn Lys Lys Ile 15 10 15 Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp Ala Leu Val Lys 20 25 30 Gin Asp Leu Glu Asn Lys Tyr Gly Glu Ile Ile Gly Cys Gly Ser Arg 35 40 45 Ile Ile Pro Met Ser Gin Asp Val Leu Gly Lys Phe Asp Ala Gly Ile 50 55 60 Ser Ile Ser Gin Thr Ala Glu Arg Thr Asn Tyr Arg Ser Val Arg Lys 65 70 75 80 Leu Ile Gin Arg Asn Thr Leu Arg Arg Glu Arg Leu His Arg Val Leu 85 90 95 His Gin Leu Asp Phe Leu Pro Lys His Tyr Asn Asp Ser Ile Asp Phe 100 105 110 Glu Lys Lys Leu Gly Gin Phe Lys Thr Asp Lys Glu Thr Lys Leu Asn 115 120 125 Tyr Phe Val Asn Gin His Gly Lys His Glu Phe Leu Phe Lys Asp Ser 130 135 140 Phe Asn Glu Met Val Lys Glu Phe Lys Glu Glu Gin Pro Glu Leu Phe 145 150 155 160 Tyr Ile Lys Asn Asn Gly Lys Glu Thr Lys Ile Pro Tyr Asp Trp Thr 165 170 175 Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Ser Lys Lys Ile Ser Lys Glu 180 185 190 Glu Leu Ser Trp Leu Val Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr 195 200 205 Gin Leu Arg Gly Glu Ile Asp Glu Glu Lys Glu Lys Asn Lys Arg Tyr 210 215 220 Glu Lys Leu Tyr Val Ser Glu Val Val Lys Thr Asn Asn Thr Ile Lys 225 230 235 240 Lys Thr Gly Glu Tyr Leu Tyr Asp Ile Tyr Phe Asp Asn Gly Trp Lys Page 2102 of 3790 Asn Asp Trp Ala Thr Leu Phe Glu Tyr Leu Asn Asn Lys Lys Glu Ile 500 505 510 Glu Gin Lys His Val Leu Glu Tyr Leu Val Ser Lys Lys Ile Ile Ser 515 520 525 Lys Ser Glu Lys Thr Asp Tyr Arg Trp Asn Tyr Val Glu Asp Lys Lys 530 535 540 Tyr Pro Gly Asn Glu Thr Arg Val Asp Phe Ile Asn Arg Leu Lys Lys 545 550 555 560 Val Glu Asn Leu Asn Val Asp Glu Phe Leu Thr Ser Glu Leu Glu Phe 565 570 575 Lys Leu Trp His Ile Ile Tyr Ser Val Thr Asp Lys Asn Glu Tyr Glu 580 585 590 Lys Ala Leu Glu Asn Phe Ala Ile Arg Gin Asn Ile Asp Lys Asp Ser 595 600 605 Phe Val Asn Ser Phe Lys Lys Phe Pro Pro Phe Lys Ser Asp Tyr Gly 610 615 620 Ala Tyr Ser Thr Lys Ala Ile Lys Lys Leu Leu Pro Leu Met Arg Leu 625 630 635 640 Gly Lys Phe Trp Asp Gly Ser Glu Ile Pro Lys Val Val Val Glu Lys 645 650 655 Ile Thr Asp Ile Lys Thr Arg Leu Thr Ser Val Asn Tyr Asp Glu Ser 660 665 670 Leu Phe Lys Lys Asp Glu Lys Lys Ile Leu Glu Thr Ile Val Asp Asp 675 680 685 Ile Thr Pro Lys Gin Leu Leu Lys Ser Phe Val Lys Leu Lys Gly Lys 690 695 700 Asn His Leu Ala Gly Leu Asn Thr Tyr Gin Ala Cys Tyr Leu Val Tyr 705 710 715 720 Glu Arg His Ser Glu Ser Ser Asp Ile Thr Gin Trp Glu Asn Pro Asp 725 730 735 Asp Ile Asp Ser Phe Leu Asn His Phe Lys Gin His Ser Leu Arg Asn 740 745 750 Page 2103 of 3790 Page 2104 of 3790 Asp Gly Glu Asn Lys Gly Lys Leu Lys Ile Lys Thr Leu Leu Asp Page 2106 of 3790 Val Gly Ser Pro Gin Ser Lys 1485 Leu Ile Lys Glu Arg Cys Ile 1500 Asn Ile Ser Lys Ala 1515 961 1629 PRT Francisella cf. 961 Ala Ile Asp Leu Gly Val Lys Asn 10 15 Gin Lys Gly Thr Ser Leu Glu Arg 25 30 Tyr Glu Leu Ser Lys Asp Ser Tyr 45 Ala Arg Arg His Gin Arg Arg Gly 60 Arg Leu Phe Lys Leu Ile Trp Thr 75 80 Lys Asp Thr Gin Gin Ala Ile Ser 90 95 Ser Phe Ile Thr Asp Gly Tyr Ser 105 110 Glu Gin Val Lys Ala Ile Leu Met 125 Glu Asp Asp Leu Asp Ser Tyr Leu 140 Lys Ile Ser Glu Ile Tyr Asn Lys 155 160 Lys Leu Arg Lys Leu Cys Thr Asp 170 175 Page 2107 of 3790 Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 180 185 190 Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ile 195 200 205 Leu Lys Thr Gin Lys Phe Ser Tyr Thr Asp Lys Gin Gly Asn Leu Lys 210 215 220 Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gin Glu Phe Leu 225 230 235 240 Lys Arg His Ala Thr Ile Asn Ile Gin Ile Leu Asp Thr Leu Leu Thr 245 250 255 Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 260 265 270 Lys Asn Glu Glu Lys Leu Gin Asn Gin Glu Asp Lys Asp His Ile Gin 275 280 285 Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 290 295 300 Met Ala Ser Gly Gly Arg His Arg Ser Gin Tyr Phe Gin Glu Ile Thr 305 310 315 320 Asn Val Leu Asp Glu Asn Asn His Gin Glu Gly Tyr Leu Lys Asn Phe 325 330 335 Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 340 345 350 Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 355 360 365 Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 370 375 380 Glu Gin Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 385 390 395 400 Arg Val Gly Val Lys Asp Gin Asp Lys Lys Asp Gly Ala Lys Tyr Ser 405 410 415 Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gin Lys Val Thr Lys Ala Gly 420 425 430 Page 2108 of 3790 Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 435 440 445 Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gin Ser Leu Ile 450 455 460 Leu Asn Pro Lys Phe Leu Asp Asn Gin Tyr Pro Asn Trp Gin Gin Tyr 465 470 475 480 Leu Gin Glu Leu Lys Lys Leu Gin Ser Ile Gin Asn Tyr Leu Glu Ser 485 490 495 Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gin Pro Tyr 500 505 510 Phe Val Glu Tyr Arg Ser Ser Asn Gin Gin Ile Ala Ser Gly Gin Arg 515 520 525 Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gin Phe Ile Phe Asp Arg 530 535 540 Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gin Ala 545 550 555 560 Lys Lys Leu Lys Gin Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 565 570 575 Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gin Leu Ser Gin Ile 580 585 590 Leu Lys Ser Gin His Thr Asn Gly Ile Phe Glu Gin Gly Thr Phe Leu 595 600 605 His Leu Val Cys Lys Tyr Tyr Lys Gin Arg Gin Arg Ala Arg Asp Ser 610 615 620 Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 625 630 635 640 Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gin Leu Leu Thr Tyr 645 650 655 Cys Asn His Lys Pro Arg Gin Lys Arg Tyr Gin Leu Leu Asn Asp Leu 660 665 670 Ala Gly Val Leu Gin Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 675 680 685 Page 2109 of 3790 Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 690 695 700 Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gin Lys Asp Asn 705 710 715 720 Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 725 730 735 Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 740 745 750 Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 755 760 765 Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 770 775 780 Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gin Ile Gin 785 790 795 800 Gin Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 805 810 815 Cys Ser Ala Asp Asn Ala His Arg Met Gin Gin Ile Lys Ile Thr Glu 820 825 830 Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gin 835 840 845 Arg Leu Pro Ala Ile Thr Thr Arg Ile Val Asp Gly Ala Val Lys Lys 850 855 860 Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gin Asn 865 870 875 880 Ile Lys Gin Val Leu Ser Ala Lys His Gin Leu His Ile Pro Ile Ile 885 890 895 Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 900 905 910 Gly Lys Ser Leu Lys 915 Asp Arg Arg Lys 920 Lys Ala Leu Glu Arg 925 Ile Ser Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Page 2111 of 3790 Page 2112 of 3790 1625 962 1646 Page 2113 of 3790 Page 2114 of 3790 Lys Arg Asn Ile Ile Ile Asn Asp Val Ile Leu Glu Lys Leu Thr Asp 245 250 255 Asp Leu Asp Ile Trp Asn Leu Asn Phe Asp Lys Phe Asp Phe Glu Lys 260 265 270 Asn Leu Glu Lys Leu Glu Asn Gin Glu Asp Lys Asp Tyr Leu Gin Thr 275 280 285 His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu Met 290 295 300 Ala Ser Gly Gly Arg His Arg Ser Gin Tyr Phe Gin Glu Ile Thr Asn 305 310 315 320 Val Leu Val Glu Asn Asn His Gin Glu Gly Tyr Leu Lys Asn Phe Cys 325 330 335 Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn Leu 340 345 350 Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu Arg 355 360 365 Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp Tyr Trp Asp Glu 370 375 380 Gin Lys Phe Ala Glu Thr Tyr Ser Asp Trp Ile Leu Gly Glu Trp Arg 385 390 395 400 Val Gly Ala Lys Asp Lys Asp Lys Lys Asp Gly Ala Lys Tyr Ser Tyr 405 410 415 Lys Asn Leu Cys Asp Glu Leu Lys Gin Lys Val Gly Ile Asn Gin Asp 420 425 430 Gly Ile Ile Asn Gin Thr Lys Ser Asp Phe Val Asp Phe Leu Leu Glu 435 440 445 Leu Asp Pro Cys Arg Thr Ile Pro Pro Tyr Leu Asp Asn Asn Asn Arg 450 455 460 Lys Pro Pro Lys Cys Gin Ser Leu Ile Leu Asn Pro Lys Phe Leu Asp 465 470 475 480 Asn Lys Tyr Pro Asn Trp Gin Gin Tyr Leu Gin Glu Leu Lys Lys Leu Page 2116 of 3790 Ile Asn Ile Ala Arg Asn Thr Lys Gly Lys Cys Glu Lys Glu Ile Phe 740 745 750 Asn Leu Ile Cys Lys Ile Glu Gly Ser Glu Asp Lys Lys Gly Asn Tyr 755 760 765 Lys His Gly Leu Ala Tyr Glu Leu Gly Val Leu Leu Phe Gly Glu Pro 770 775 780 Asn Gin Ala Ser Lys Leu Glu Phe Asp Arg Lys Ile Lys Lys Phe Asn 785 790 795 800 Ser Ile Tyr Ser Phe Ala Gin Ile Gin Gin Ile Ala Phe Ala Glu Arg 805 810 815 Lys Gly Asn Ala Asn Thr Cys Ala Val Cys Ser Ala Asp Asn Ala His 820 825 830 Arg Met Gin Gin Ile Lys Val Ala Lys Pro Val Glu Gly Asn Lys Asp 835 840 845 Asn Ile Ile Leu Ser Ala Lys Ala Gin Arg Leu Pro Ala Ile Pro Thr 850 855 860 Arg Ile Val Asp Gly Ala Val Lys Lys Ile Ala Thr Ile Leu Ala Arg 865 870 875 880 Asn Ile Val Asp Asp Asn Trp Asp Asn Ile Lys Gin Ala Leu Ser Asn 885 890 895 Asn Gin Gin Leu His Val Pro Ile Ile Thr Glu Ser Asn Ala Phe Glu 900 905 910 Phe Glu Pro Ala Leu Ala Asp Ile Lys Gly Lys Ser Leu Lys Asp Lys 915 920 925 Arg Lys Lys Ala Leu Glu Arg Ile Asp Pro Glu Asn Val Phe Lys Asp 930 935 940 Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala Tyr Ser 945 950 955 960 Asp Ala Asn Leu Ala Asn Gly Asp Phe Asp Gly Ala Lys Glu Glu Leu 965 970 975 Asp His Ile Ile Pro Arg Ser His Lys Lys Tyr Gly Thr Leu Asn Asp 980 985 990 Page 2117 of 3790 Glu Ala Asn Leu Ile Cys Val Thr Arg Glu Asp Asn Gin Asn Arg Gly 995 1000 1005 Page 2118 of 3790 Ser Leu Pro Ile Ser Thr Asn Glu Gly Lys Leu Leu Val Lys Arg Page 2119 of 3790 1460 1465 1470 1640 1645 963 1629 PRT Francisella novicida 963 Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 15 10 15 Thr Gly Val Phe Ser Ala Phe Tyr Gin Lys Gly Thr Ser Leu Glu Arg Page 2120 of 3790 25 30 Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 35 40 45 Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gin Arg Arg Gly 50 55 60 Ile Asp Arg Lys Gin Leu Val Lys Lys Leu Phe Lys Leu Ile Trp Thr 65 70 75 80 Glu Gin Leu Asn Leu Glu Trp Asp Lys Asp Thr Gin Gin Ala Ile Ser 85 90 95 Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 100 105 110 Pro Glu Tyr Leu Asn Ile Val Pro Glu Gin Val Lys Ala Ile Leu Met 115 120 125 Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 130 135 140 Lys Leu Ala Thr Glu Gin Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 145 150 155 160 Leu Met Gin Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 165 170 175 Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 180 185 190 Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 195 200 205 Leu Lys Thr Gin Lys Phe Ser Tyr Thr Asp Lys Gin Gly Asn Leu Lys 210 215 220 Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gin Glu Phe Leu 225 230 235 240 Lys Arg His Ala Thr Ile Asn Asp Glu Ile Leu Asp Thr Leu Leu Thr 245 250 255 Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 260 265 270 Page 2121 of 3790 Lys Asn Glu Glu Lys Leu Gin Asn Gin Glu Asp Lys Asp His Thr Gin 275 280 285 Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 290 295 300 Met Ala Ser Gly Gly Arg His Arg Gly Gin Tyr Phe Gin Glu Ile Thr 305 310 315 320 Asn Val Leu Asp Glu Asn Asn His Gin Glu Gly Tyr Leu Lys Asn Phe 325 330 335 Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 340 345 350 Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 355 360 365 Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 370 375 380 Glu Gin Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 385 390 395 400 Arg Val Gly Leu Lys Asp Gin Asp Lys Lys Glu Gly Ala Lys Tyr Ser 405 410 415 Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gin Lys Val Thr Asn Ala Gly 420 425 430 Leu Ile Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 435 440 445 Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gin Ser Leu Ile 450 455 460 Leu Asn Pro Lys Phe Leu Asp Asn Gin Tyr Pro Asn Trp Gin Gin Tyr 465 470 475 480 Leu Gin Glu Leu Lys Lys Leu Gin Ile Ile Gin Asp Tyr Leu Glu Ser 485 490 495 Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gin Pro Tyr 500 505 510 Phe Val Glu Tyr Lys Ser Ser Asn Gin Gin Ile Ala Ser Gly Gin Arg 515 520 525 Page 2122 of 3790 Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gin Phe Ile Phe Asp Arg 530 535 540 Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gin Ala 545 550 555 560 Lys Lys Leu Lys Gin Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 565 570 575 Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gin Leu Ser Lys Ile 580 585 590 Leu Lys Ser Gin His Thr Asn Gly Ile Phe Glu Gin Gly Thr Phe Leu 595 600 605 His Leu Val Cys Lys Tyr Tyr Lys Gin Arg Gin Arg Ala Arg Asp Ser 610 615 620 Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu Asp Lys 625 630 635 640 Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gin Leu Leu Thr Tyr 645 650 655 Cys Asn His Lys Pro Arg Gin Lys Arg Tyr Gin Leu Leu Asn Asp Leu 660 665 670 Ala Gly Val Leu Gin Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 675 680 685 Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 690 695 700 Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gin Lys Asp Asn 705 710 715 720 Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 725 730 735 Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 740 745 750 Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 755 760 765 Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 770 775 780 Page 2123 of 3790 Glu Ile Glu Lys Lys Ile Ala Asp Thr Ile Trp Asp Ala Ser Lys Page 2125 of 3790 Page 2126 of 3790 Asn Glu Thr Ser Asn Asn 1625 964 1629 PRT Francisella novicida 964 Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 15 10 15 Thr Gly Val Phe 20 Ser Ala Phe Tyr Gin Lys 25 Gly Thr Ser Leu 30 Glu Arg Leu Asp Asn Lys Asn Gly Lys 35 Val Tyr Glu Leu Ser Lys Asp 45 Ser Tyr Thr Leu Leu Met Asn Asn Arg 55 Thr Ala Arg Arg His Gin Arg Arg Gly Ile Asp Arg Lys Gin Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 65 70 75 80 Page 2127 of 3790 Glu Gin Leu Asn Leu Glu Trp Asp Lys Asp Thr Gin Gin Ala Ile Ser 85 90 95 Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 100 105 110 Pro Glu Tyr Leu Asn Ile Val Pro Glu Gin Val Lys Ala Ile Leu Met 115 120 125 Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 130 135 140 Lys Leu Ala Thr Glu Gin Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 145 150 155 160 Leu Met Gin Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 165 170 175 Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 180 185 190 Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 195 200 205 Leu Lys Thr Gin Lys Phe Ser Tyr Thr Asp Lys Gin Gly Asn Leu Lys 210 215 220 Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gin Glu Phe Leu 225 230 235 240 Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 245 250 255 Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 260 265 270 Lys Asn Glu Glu Lys Leu Gin Asn Gin Glu Asp Lys Asp His Ile Gin 275 280 285 Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 290 295 300 Met Ala Ser Gly Gly Arg His Arg Ser Gin Tyr Phe Gin Glu Ile Thr 305 310 315 320 Asn Val Leu Asp Glu Asn Asn His Gin Glu Gly Tyr Leu Lys Asn Phe 325 330 335 Page 2128 of 3790 Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 340 345 350 Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 355 360 365 Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 370 375 380 Glu Gin Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 385 390 395 400 Arg Val Gly Val Lys Asp Gin Asp Lys Lys Asp Gly Ala Lys Tyr Ser 405 410 415 Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gin Lys Val Thr Lys Ala Gly 420 425 430 Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 435 440 445 Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gin Ser Leu Ile 450 455 460 Leu Asn Pro Lys Phe Leu Asp Asn Gin Tyr Pro Asn Trp Gin Gin Tyr 465 470 475 480 Leu Gin Glu Leu Lys Lys Leu Gin Ser Ile Gin Asn Tyr Leu Asp Ser 485 490 495 Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gin Pro Tyr 500 505 510 Phe Val Glu Tyr Lys Ser Ser Asn Gin Gin Ile Ala Ser Gly Gin Arg 515 520 525 Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gin Phe Ile Phe Asp Arg 530 535 540 Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gin Ala 545 550 555 560 Lys Lys Leu Lys Gin Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 565 570 575 Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gin Leu Ser Gin Ile Page 2130 of 3790 Glu Asn Pro Ile Lys Gin Ala Val Ile Arg Ala Ile Asn Asn Arg 1070 1075 1080 Page 2131 of 3790 Page 2132 of 3790 Tyr Lys Ile Asp Asn Asn Ser Arg Pro Lys Val Arg Val Lys Leu Page 2133 of 3790 1550 1555 1560 Leu Gin Asn Gin Glu Asp Lys Asp His Thr Gin Ala Tyr Leu His His Phe Asp Tyr Phe Gly Ile Pro Thr Ile Gly Asn Gly Arg Gly Ile Ala Page 2136 of 3790 Page 2137 of 3790 Page 2138 of 3790 Gin Lys Ile Gly Glu Ser Leu Gly Leu Asn Asp Lys Gin Ile Lys Lys 130 135 140 Phe Asn Ser Ile Tyr Asn Phe Ala Gin Ile Gin Gin Ile Ala Phe Ala 145 150 155 160 Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val Tyr Ser Ala Asp Asn 165 170 175 Ala His Arg Met Gin Gin Ile Lys Ile Thr Glu Leu Val Glu Asp Asn 180 185 190 Lys Asp Asn Ile Ile Leu Ser Ala Lys Ala Gin Arg Leu Pro Ala Ile 195 200 205 Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys Met Ala Thr Ile Leu 210 215 220 Ala Lys Asn Ile Val Asp Asp Asn Trp Gin Asn Ile Lys Gin Val Leu 225 230 235 240 Ser Ala Lys His Gin Leu His Ile Pro Ile Ile Thr Glu Ser Asn Ala 245 250 255 Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys Gly Lys Ser Leu Lys 260 265 270 Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser Pro Glu Asn Ile Phe 275 280 285 Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala Lys Gly Ile Ser Ala 290 295 300 Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe Asp Gly Ala Lys Glu 305 310 315 320 Glu Leu Asp His Ile Ile Pro Arg Ser Tyr Lys Lys Tyr Gly Thr Leu 325 330 335 Asn Asp Glu Val Asn Leu Ile Cys Val Thr Arg Asp Asp Asn Lys Asn 340 345 350 Lys Gly Lys Arg Ile Phe Cys Leu Asn Asp Leu Ala Asn Asn Tyr Lys 355 360 365 Leu Lys Gin Phe Glu Thr Thr Asp Asp Leu Glu Ile Glu Lys Lys Ile 370 375 380 Page 2139 of 3790 Ala Asp Thr Ile Trp Asp Ala Ser Lys Gin Asp Phe Lys Phe Gly Asn 385 390 395 400 Tyr Arg Ser Phe Ile Asn Leu Ile Pro Gin Glu Gin Lys Ala Phe Arg 405 410 415 Tyr Ala Leu Phe Leu Ala Asp Glu Asn Ser Ile Lys Gin Ala Val Ile 420 425 430 Arg Ala Ile Asn Asn Arg Asn Arg Thr Phe Val Asn Gly Thr Gin Arg 435 440 445 Tyr Phe Ala Glu Val Leu Ala Asn Asn Ile Tyr Leu Arg Ala Lys Lys 450 455 460 Glu Asn Leu Asn Thr Asp Lys Ile Ser Phe Asp Tyr Phe Gly Ile Pro 465 470 475 480 Thr Ile Gly Asn Gly Arg Gly Ile Ala Asp Ile Arg Gin Leu Tyr Glu 485 490 495 Lys Val Asp Ser Asp Ile Gin Ala Tyr Ala Lys Gly Asp Lys Pro Gin 500 505 510 Ala Ser Tyr Ser His Leu Ile Asp Ala Met Ile Ala Phe Cys Val Ala 515 520 525 Ala Asp Glu His Arg Asn Asp Gly Ser Ile Gly Leu Glu Ile Asp Lys 530 535 540 Asn Tyr Ser Leu Tyr Pro Leu Asp Lys Asn Thr Gly Glu Val Phe Thr 545 550 555 560 Lys Asp Ile Phe Ser Gin Ile Lys Ile Thr Asp Asn Glu Phe Ser Asp 565 570 575 Lys Lys Leu Val Arg Lys Lys Ala Thr Glu Gly Phe Asn Thr His Arg 580 585 590 Gin Met Thr Arg Asp Gly Ile Tyr Ala Glu Asn Tyr Leu Pro Ile Leu 595 600 605 Ile His Lys Glu Leu Asp Glu Val Arg Lys Gly Tyr Thr Trp Gly Asn 610 615 620 Ser Glu Glu Leu Lys Ile His Lys Gly Lys Lys Tyr Asn Ile Gin Gin 625 630 635 640 Page 2140 of 3790 Leu Asn Asn Ile Val Tyr Cys Leu Lys Phe Ile Asp Lys Ser Ile Ser 645 650 655 Ile Asp Ile Gin Ile Ser Thr Leu Glu Glu Leu Arg Asn Ile Leu Thr 660 665 670 Thr Asn Asn Ile Ala Ala Thr Ala Glu Tyr Tyr Tyr Ile Asn Leu Lys 675 680 685 Asn Gin Lys Leu His Glu Tyr Tyr Ile Glu Asn Tyr Asn Thr Ala Leu 690 695 700 Asp Tyr Lys Lys Tyr Ser Lys Glu Met Glu Phe Leu Arg Ser Leu Ala 705 710 715 720 Tyr Arg Ser Glu Arg Val Lys Ile Lys Ser Ile Asp Asp Val Lys Gin 725 730 735 Val Leu Asp Lys Asp Ser Asn Phe Ile Ile Gly Lys Ile Thr Leu Pro 740 745 750 Phe Lys Lys Glu Trp Gin Arg Leu Tyr Leu Glu Trp Gin Asn Thr Thr 755 760 765 Ile Lys Asp Asp Tyr Glu Phe Leu Lys Ser Phe Phe Asn Val Lys Ser 770 775 780 Ile Asn Lys Leu His Lys Lys Val Arg Lys Asp Phe Ser Leu Pro Ile 785 790 795 800 Ser Thr Asn Glu Gly Lys Phe Leu Val Lys Arg Lys Thr Trp Asp Asn 805 810 815 Asn Phe Ile Tyr Gin Ile Leu Asn Asp Ser Asp Ser Arg Val Asp Gly 820 825 830 Thr Lys Pro Phe Ile Pro Ala Phe Asp Ile Ser Lys Asn Glu Ile Val 835 840 845 Glu Ala Ile Ile Asp Ser Phe Thr Ser Lys Asn Ile Phe Trp Leu Pro 850 855 860 Lys Asn Ile Glu Leu Gin Lys Val Asp Lys Ile Phe Leu Leu 865 870 875 969 Page 2141 of 3790 292 PRT Francisella tularensis 969 Met Leu Asn Asp Leu Ala Gly Val Leu Gin Val Ser Arg Asn Gin Leu 15 10 15 Leu Ser Ser Val Glu Glu Trp Phe Gin Gin Ala Gin Arg Val Gly Glu 20 25 30 Ile Ser Lys Ser Gin Asp Glu Gin Ile Phe Glu Trp Leu Lys Ser Phe 35 40 45 Lys Ile Ala Ser Tyr Cys Lys Ala Ala Val Glu Met Gin Lys Gin Tyr 50 55 60 Arg Gly Thr Leu Lys Asn Ala Ile Gin Thr Ala Ile Phe Arg Gin Ser 65 70 75 80 Glu Asn Ile Asn Lys Asn Lys Asn Lys Asn Thr Gly Asn Gin Gin Gin 85 90 95 Ala Leu Ser Glu Asn Ser Lys Asp Val Lys Ser Leu Thr Ala Asp Glu 100 105 110 Lys Lys Leu Leu Lys Leu Ile Glu Asn Ile Ala Lys Ala Ser Gin Lys 115 120 125 Ile Gly Glu Ser Leu Gly Leu Asn Asp Lys Gin Ile Lys Lys Phe Asn 130 135 140 Ser Ile Tyr Asn Phe Ala Gin Ile Gin Gin Ile Ala Phe Ala Glu Arg 145 150 155 160 Lys Gly Asn Ala Asn Thr Cys Ala Val Tyr Ser Ala Asp Asn Ala His 165 170 175 Arg Met Gin Gin Ile Lys Ile Thr Glu Leu Val Glu Asp Asn Lys Asp 180 185 190 Asn Ile Ile Leu Ser Ala Lys Ala Gin Arg Leu Pro Ala Ile Pro Thr 195 200 205 Arg Ile Val Asp Gly Ala Val Lys Lys Met Val Thr Ile Leu Ala Lys 210 215 220 Asn Ile Val Asp Asp Asn Trp Gin Asn Ile Lys Gin Val Leu Ser Ala Page 2143 of 3790 Ile Asp Arg Lys Gin Leu Val Lys Arg Leu Phe Lys Leu Val Trp Thr 65 70 75 80 Glu Gin Leu Asn Leu Glu Trp Asp Lys Asp Thr Gin Gin Ala Ile Ser 85 90 95 Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 100 105 110 Thr Glu Tyr Leu Asn Ile Val Pro Glu Gin Val Lys Ala Ile Leu Met 115 120 125 Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 130 135 140 Lys Leu Ala Thr Glu Gin Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 145 150 155 160 Leu Met Gin Lys Ile Leu Glu Phe Lys Leu Arg Lys Leu Cys Thr Asp 165 170 175 Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 180 185 190 Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 195 200 205 Leu Lys Thr Gin Lys Phe Ser Tyr Thr Asp Lys Gin Gly Asn Leu Lys 210 215 220 Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gin Glu Phe Leu 225 230 235 240 Lys Arg His Ala Thr Ile Asn Asp Glu Ile Leu Asp Thr Leu Leu Thr 245 250 255 Asp Asp Phe Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 260 265 270 Lys Asn Glu Glu Lys Leu Gin Asn Gin Glu Asp Lys Asp His Thr Gin 275 280 285 Ala Tyr Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 290 295 300 Met Ala Ser Gly Gly Arg His Arg Ser Gin Tyr Phe Gin Glu Ile Thr Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu Page 2146 of 3790 Glu Gin Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 385 390 395 400 Arg Val Gly Val Lys Asp Gin Asp Lys Lys Asp Gly Ala Lys Tyr Ser 405 410 415 Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gin Lys Val Thr Lys Ala Gly 420 425 430 Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 435 440 445 Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gin Ser Leu Ile 450 455 460 Leu Asn Pro Lys Phe Leu Asp Asn Gin Tyr Pro Asn Trp Gin Gin Tyr 465 470 475 480 Leu Gin Glu Leu Lys Lys Leu Gin Ser Ile Gin Asn Tyr Leu Glu Ser 485 490 495 Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gin Pro Tyr 500 505 510 Phe Val Glu Tyr Lys Ser Ser Asn Gin Gin Ile Ala Ser Gly Gin Arg 515 520 525 Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gin Phe Ile Phe Asp Arg 530 535 540 Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gin Ala 545 550 555 560 Lys Lys Leu Lys Gin Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 565 570 575 Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gin Leu Ser Gin Ile 580 585 590 Leu Lys Ser Gin His Thr Asn Gly Ile Phe Glu Gin Gly Thr Phe Leu 595 600 605 His Leu Val Cys Lys Tyr Tyr Lys Gin Arg Gin Arg Ala Arg Asp Ser 610 615 620 Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu Asp Lys 625 630 635 640 Page 2147 of 3790 Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gin Leu Leu Thr Tyr 645 650 655 Cys Asn His Lys Pro Arg Gin Lys Arg Tyr Gin Leu Leu Asn Asp Leu 660 665 670 Ala Gly Val Leu Gin Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 675 680 685 Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 690 695 700 Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gin Lys Asp Asn 705 710 715 720 Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 725 730 735 Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 740 745 750 Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 755 760 765 Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 770 775 780 Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gin Ile Gin 785 790 795 800 Gin Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 805 810 815 Cys Ser Ala Asp Asn Ala His Arg Met Gin Gin Ile Lys Ile Thr Glu 820 825 830 Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gin 835 840 845 Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 850 855 860 Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gin Asn 865 870 875 880 Ile Lys Gin Val Leu Ser Ala Lys His Gin Leu His Ile Pro Ile Ile 885 890 895 Page 2148 of 3790 Asn Gly Arg Gly Ile Val Glu Ile Arg Gin Leu Tyr Glu Lys Val Page 2150 of 3790 Page 2151 of 3790 Lys Thr Ile Lys Glu Met Leu Gly Met Thr Leu Ala Gly Ile Tyr Page 2152 of 3790 Thr Lys Leu His Lys Lys Val Arg Lys Asp Phe Ser Leu Pro Ile Ser 195 200 205 Thr Asn Glu Gly Lys Phe Leu Val Lys Arg Lys Thr Trp Asp Asn Asn 210 215 220 Phe Ile Tyr Gin Ile Leu Asn Asp Ser Asp Ser Arg Val Asp Gly Thr 225 230 235 240 Lys Pro Phe Ile Pro Ala Phe Asp Ile Ser Lys Asn Glu Ile Val Glu 245 250 255 Ala Ile Ile Asp Ser Phe Thr Ser Lys Asn Ile Phe Trp Leu Pro Lys 260 265 270 Asn Ile Glu Leu Gin Lys Val Asp Lys Ile Phe Leu Leu 275 280 285 974 1323 PRT Fructobacillus fructosus 974 Met Val Tyr Asp Val Gly Leu Asp Ile Gly Thr Gly Ser Val Gly Trp 15 10 15 Val Ala Leu Asp Glu Asn Gly Lys Leu Ala Arg Ala Lys Gly Lys Asn 20 25 30 Leu Val Gly Val Arg Leu Phe Asp Thr Ala Gin Thr Ala Ala Asp Arg 35 40 45 Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg Lys Trp Arg 50 55 60 Leu Arg Leu Leu Asp Glu Leu Phe Ser Ala Glu Ile Asn Glu Ile Asp 65 70 75 80 Ser Ser Phe Phe Gin Arg Leu Lys Tyr Ser Tyr Val His Pro Lys Asp 85 90 95 Glu Glu Asn Lys Ala His Tyr Tyr Gly Gly Tyr Leu Phe Pro Thr Glu 100 105 110 Glu Glu Thr Lys Lys Phe His Arg Ser Tyr Pro Thr Ile Tyr His Leu 115 120 125 Page 2153 of 3790 Arg Gin Glu Leu Met Ala Gin Pro Asn Lys Arg Phe Asp Ile Arg Glu 130 135 140 Ile Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His Phe Leu 145 150 155 160 Ser Ser Gin Glu Lys Ile Thr Ile Gly Ser Thr Tyr Asn Pro Glu Asp 165 170 175 Leu Ala Asn Ala Ile Glu Val Tyr Ala Asp Glu Lys Gly Leu Ser Trp 180 185 190 Glu Leu Asn Asn Pro Glu Gin Leu Thr Glu Ile Ile Ser Gly Glu Ala 195 200 205 Gly Tyr Gly Leu Asn Lys Ser Met Lys Ala Asp Glu Ala Leu Lys Leu 210 215 220 Phe Glu Phe Asp Asn Asn Gin Asp Lys Val Ala Ile Lys Thr Leu Leu 225 230 235 240 Ala Gly Leu Thr Gly Asn Gin Ile Asp Phe Ala Lys Leu Phe Gly Lys 245 250 255 Asp Ile Ser Asp Lys Asp Glu Ala Lys Leu Trp Lys Leu Lys Leu Asp 260 265 270 Asp Glu Ala Leu Glu Glu Lys Ser Gin Thr Ile Leu Ser Gin Leu Thr 275 280 285 Asp Glu Glu Ile Glu Leu Phe His Ala Val Val Gin Ala Tyr Asp Gly 290 295 300 Phe Val Leu Ile Gly Leu Leu Asn Gly Ala Asp Ser Val Ser Ala Ala 305 310 315 320 Met Val Gin Leu Tyr Asp Gin His Arg Glu Asp Arg Lys Leu Leu Lys 325 330 335 Ser Leu Ala Gin Lys Ala Gly Leu Lys His Lys Arg Phe Ser Glu Ile 340 345 350 Tyr Glu Gin Leu Ala Leu Ala Thr Asp Glu Ala Thr Ile Lys Asn Gly 355 360 365 Ile Ser Thr Ala Arg Glu Leu Val Glu Glu Ser Asn Leu Ser Lys Glu 370 375 380 Page 2154 of 3790 Val Lys Glu Asp Thr Leu Arg Arg Leu Asp Glu Asn Glu Phe Leu Pro 385 390 395 400 Lys Gin Arg Thr Lys Ala Asn Ser Val Ile Pro His Gin Leu His Leu 405 410 415 Ala Glu Leu Gin Lys Ile Leu Gin Asn Gin Gly Gin Tyr Tyr Pro Phe 420 425 430 Leu Leu Asp Thr Phe Glu Lys Glu Asp Gly Gin Asp Asn Lys Ile Glu 435 440 445 Glu Leu Leu Arg Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr 450 455 460 Lys Lys Asp Val Glu His Ala Gly Gly Asp Ala Asp Asn His Trp Val 465 470 475 480 Glu Arg Asn Glu Gly Phe Glu Lys Ser Arg Val Thr Pro Trp Asn Phe 485 490 495 Asp Lys Val Phe Asn Arg Asp Lys Ala Ala Arg Asp Phe Ile Glu Arg 500 505 510 Leu Thr Gly Asn Asp Thr Tyr Leu Ile Gly Glu Lys Thr Leu Pro Gin 515 520 525 Asn Ser Leu Arg Tyr Gin Leu Phe Thr Val Leu Asn Glu Leu Asn Asn 530 535 540 Val Arg Val Asn Gly Lys Lys Phe Asp Ser Lys Thr Lys Ala Asp Leu 545 550 555 560 Ile Asn Asp Leu Phe Lys Ala Arg Lys Thr Val Ser Leu Ser Ala Leu 565 570 575 Lys Asp Tyr Leu Lys Ala Gin Gly Lys Gly Asp Val Thr Ile Thr Gly 580 585 590 Leu Ala Asp Glu Ser Lys Phe Asn Ser Ser Leu Ser Ser Tyr Asn Asp 595 600 605 Leu Lys Lys Thr Phe Asp Ala Glu Tyr Leu Glu Asn Glu Asp Asn Gin 610 615 620 Glu Thr Leu Glu Lys Ile Ile Glu Ile Gin Thr Val Phe Glu Asp Ser Page 2156 of 3790 Tyr Ser Ala Tyr Met Thr Leu Val Arg Ala Asn Gly Lys Asn Leu 1115 1120 1125 Page 2157 of 3790 975 1367 PRT Fusobacterium sp. 975 Met Lys Lys Gin Lys Phe Ser Asp Tyr Tyr Leu Gly Phe Asp Ile Gly 15 10 15 Page 2158 of 3790 Thr Asn Ser Val Gly Trp Cys Val Thr Asp Leu Asp Tyr Asn Val Leu 20 25 30 Arg Phe Asn Lys Lys Asp Met Trp Gly Ser Arg Leu Phe Asp Glu Ala 35 40 45 Lys Thr Ala Ala Glu Arg Arg Val Gin Arg Asn Ser Arg Arg Arg Leu 50 55 60 Lys Arg Arg Lys Trp Arg Leu Asn Leu Leu Glu Glu Ile Phe Ser Asp 65 70 75 80 Glu Ile Met Lys Ile Asp Ser Asn Phe Phe Arg Arg Leu Lys Glu Ser 85 90 95 Ser Leu Trp Leu Glu Asp Lys Asn Ser Lys Glu Lys Phe Thr Leu Phe 100 105 110 Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gin Tyr Pro Thr 115 120 125 Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 130 135 140 Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 145 150 155 160 His Phe Leu Phe Glu Gly Gin Asn Leu Lys Glu Ile Lys Asn Phe Glu 165 170 175 Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 180 185 190 Lys Ser Ile Asp Lys Asp Asn Ile Lys Lys Leu Glu Lys Ile Ile Cys 195 200 205 Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 210 215 220 Phe Asn Ser Asp Lys Gin Leu Val Ala Ile Phe Lys Leu Ser Val Gly 225 230 235 240 Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 245 250 255 Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gin Ile Tyr Glu 260 265 270 Page 2159 of 3790 Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 275 280 285 Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 290 295 300 Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 305 310 315 320 Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 325 330 335 Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 340 345 350 Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val 355 360 365 Val Glu Lys Ser Gly Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 370 375 380 Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Thr Ile 385 390 395 400 Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 405 410 415 Gin Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gin Ile His Glu Val 420 425 430 Glu Leu Glu Lys Ile Leu Glu Asn Gin Ser Lys Tyr Tyr Asp Phe Leu 435 440 445 Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 450 455 460 Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 465 470 475 480 Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 485 490 495 Ile Leu Pro Trp Asn Phe Glu Gin Lys Val Asp Ile Glu Lys Ser Ala 500 505 510 Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly Page 2160 of 3790 515 520 525 Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 530 535 540 Leu Asn Glu Leu Asn Lys Val Gin Val Asn Asp Glu Phe Leu Asn Glu 545 550 555 560 Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 565 570 575 Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gin Ile Ala 580 585 590 Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 595 600 605 Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 610 615 620 Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 625 630 635 640 Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 645 650 655 Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 660 665 670 Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 675 680 685 Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 690 695 700 Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 705 710 715 720 Phe Thr Leu Gin Glu Ser Ile Asp Asn Gly Asn Lys Glu Met Asn Glu 725 730 735 Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 740 745 750 Lys Arg Ala Ile Leu Gin Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 755 760 765 Page 2161 of 3790 Ile Val Ala Gly Asn Val Tyr Asn Thr Lys Phe Thr Glu Lys Pro 1010 1015 1020 Page 2162 of 3790 Page 2163 of 3790 976 1367 PRT Fusobacterium sp. 976 Page 2164 of 3790 Asn Asp Asp Asn Tyr Lys Asp Tyr Asp Phe Tyr Lys Gin Tyr Pro Thr 115 120 125 Ile Phe His Leu Arg Asp Glu Leu Ile Lys Asn Pro Glu Lys Lys Asp 130 135 140 Ile Arg Leu Ile Tyr Leu Ala Leu His Ser Ile Phe Lys Ser Arg Gly 145 150 155 160 His Phe Leu Phe Glu Gly Gin Asn Leu Lys Glu Ile Lys Asn Phe Glu 165 170 175 Thr Leu Tyr Asn Asn Leu Ile Ser Phe Leu Glu Asp Asn Gly Ile Asn 180 185 190 Lys Ser Ile Asp Lys Asp Asn Ile Lys Lys Leu Glu Lys Ile Ile Cys 195 200 205 Asp Ser Gly Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 210 215 220 Phe Asn Ser Asp Lys Gin Leu Val Ala Ile Phe Lys Leu Ser Val Gly 225 230 235 240 Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 245 250 255 Glu Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gin Ile Tyr Glu 260 265 270 Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Leu 275 280 285 Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 290 295 300 Leu Ser Asp Ser Asn Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Glu 305 310 315 320 Glu His Lys Lys Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 325 330 335 Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Asn Asn 340 345 350 Tyr Pro Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val Page 2165 of 3790 355 360 365 Val Glu Lys Ser Gly Leu Lys Ile Asp Asp Leu Ile Lys Val Ile Lys 370 375 380 Gly Tyr Leu Pro Lys Pro Glu Arg Ile Glu Glu Lys Asp Lys Ile Ile 385 390 395 400 Phe Asn Glu Ile Leu Asn Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 405 410 415 Gin Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gin Ile His Glu Val 420 425 430 Glu Leu Glu Lys Ile Leu Glu Asn Gin Ser Lys Tyr Tyr Asp Phe Leu 435 440 445 Asn Tyr Glu Glu Asn Gly Val Ser Thr Lys Asp Lys Leu Leu Lys Thr 450 455 460 Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 465 470 475 480 Lys Asp Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 485 490 495 Ile Leu Pro Trp Asn Phe Glu Gin Lys Val Asp Ile Glu Lys Ser Ala 500 505 510 Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 515 520 525 Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 530 535 540 Leu Asn Glu Leu Asn Lys Val Gin Val Asn Asp Glu Phe Leu Asn Glu 545 550 555 560 Glu Asn Lys Arg Lys Ile Ile Asp Glu Leu Phe Lys Glu Asn Lys Lys 565 570 575 Val Ser Glu Lys Lys Phe Lys Glu Tyr Leu Leu Val Asn Gin Ile Ala 580 585 590 Asn Arg Thr Val Glu Leu Lys Gly Ile Lys Asp Ser Phe Asn Ser Asn 595 600 605 Page 2166 of 3790 Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Glu Lys Leu Asn 610 615 620 Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 625 630 635 640 Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Asn Glu 645 650 655 Tyr Gly Asp Ile Leu Asn Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 660 665 670 Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Gly Ile 675 680 685 Glu Phe Ile Asn Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Glu 690 695 700 Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 705 710 715 720 Phe Thr Leu Gin Glu Ser Ile Asp Asn Gly Asn Lys Glu Met Asn Glu 725 730 735 Val Ser Tyr Arg Asp Leu Ile Glu Glu Ser Tyr Val Ser Pro Ser Leu 740 745 750 Lys Arg Ala Ile Leu Gin Thr Leu Lys Ile Tyr Glu Glu Ile Lys Lys 755 760 765 Ile Thr Gly Arg Val Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 770 775 780 Gly Asp Glu Thr Met Lys Asn Lys Lys Ile Pro Ala Arg Gin Glu Gin 785 790 795 800 Leu Lys Lys Leu Tyr Asp Ser Cys Gly Asn Asp Ile Ala Asn Phe Ser 805 810 815 Ile Asp Ile Lys Lys Met Lys Ser Ser Leu Ser Ser Tyr Asp Asn Asn 820 825 830 Ser Leu Arg Gin Lys Lys Leu Tyr Leu Tyr Tyr Leu Gin Phe Gly Lys 835 840 845 Cys Met Tyr Thr Gly Arg Glu Ile Asp Leu Asp Arg Leu Leu Gin Asn 850 855 860 Page 2167 of 3790 Pro Lys Leu Tyr Asn Gly Lys Glu Glu Lys Leu Asn Glu Lys Tyr 1100 1105 1110 Page 2168 of 3790 Lys Ile Ser Ser Asn Val Leu Ser Lys Asn Glu Leu Tyr Leu Leu 1340 Page 2169 of 3790 1345 1350 Glu Glu Ser Val Thr Gly Leu Phe Val Lys Lys Ile Lys Leu 1355 1360 1365 977 1367 PRT Fusobacterium sp. 977 Met Lys Lys Gin Gin Phe Ser Asp 1 5 Tyr Tyr Leu Gly Phe Asp Ile Gly 10 15 Thr Asn Ser Val Gly Trp Cys Val 20 Thr Asp Phe Asn Tyr Asn Val Leu 25 30 Arg Phe Asn Lys Lys Asp Met Trp 35 40 Gly Ser Arg Leu Phe Asp Glu Ala 45 Lys Thr Ala Ala Glu Arg Arg Val 50 55 Gin Arg Asn Ser Arg Arg Arg Leu 60 Lys Arg Arg Lys Trp Arg Leu Asn 65 70 Leu Leu Glu Glu Ile Phe Ser Asp 75 80 Glu Ile Leu Lys Ile Asp Ser Asn 85 Phe Phe Arg Arg Leu Lys Glu Ser 90 95 Ser Leu Trp Leu Glu Asp Lys Ser 100 Ser Lys Glu Lys Phe Thr Leu Phe 105 110 Asn Asp Asp Asn Tyr Lys Asp Tyr 115 120 Asp Phe Tyr Lys Gin Tyr Pro Thr 125 Ile Phe His Leu Arg Asn Glu Leu 130 135 Ile Lys Asn Pro Glu Lys Lys Asp 140 Ile Arg Leu Val Tyr Leu Ala Leu 145 150 His Ser Ile Phe Lys Ser Arg Gly 155 160 His Phe Leu Phe Glu Gly Gin Asn 165 Leu Lys Asp Ile Lys Asn Phe Glu 170 175 Thr Leu Tyr Asn Asn Leu Met Ala 180 Phe Leu Glu Asp Asn Asp Ile Tyr 185 190 Lys Asn Ile Asp Ser Ser Tyr Ile Gly Asn Leu Glu Asn Ile Ile Cys Page 2170 of 3790 195 200 205 Asp Ser Lys Lys Gly Leu Lys Asp Lys Glu Lys Glu Phe Lys Glu Ile 210 215 220 Phe Asn Ser Asp Lys Gin Leu Val Gly Phe Phe Lys Leu Ser Val Gly 225 230 235 240 Ser Ser Val Ser Leu Asn Asp Leu Phe Asp Thr Asp Glu Tyr Lys Lys 245 250 255 Gly Glu Val Glu Lys Glu Lys Ile Ser Phe Arg Glu Gin Ile Tyr Glu 260 265 270 Asp Asp Lys Pro Ile Tyr Tyr Ser Ile Leu Gly Glu Lys Ile Glu Phe 275 280 285 Leu Asp Ile Ala Lys Ser Phe Tyr Asp Phe Met Val Leu Asn Asn Ile 290 295 300 Leu Ala Asp Ser Gin Tyr Ile Ser Glu Ala Lys Val Lys Leu Tyr Asp 305 310 315 320 Glu His Lys Arg Asp Leu Lys Asn Leu Lys Tyr Ile Ile Arg Lys Tyr 325 330 335 Asn Lys Glu Asn Tyr Asp Lys Leu Phe Lys Asp Lys Asn Glu Ser Asn 340 345 350 Tyr Ser Ala Tyr Ile Gly Leu Asn Lys Glu Lys Gly Lys Lys Glu Val 355 360 365 Ile Glu Lys Ser Arg Leu Lys Ile Asp Asp Phe Ala Lys Ile Ile Lys 370 375 380 Gly Tyr Leu Pro Lys Ala Glu Lys Ile Asp Glu Lys Asp Arg Ser Ile 385 390 395 400 Phe Asn Glu Ile Leu Asp Lys Ile Glu Leu Lys Thr Ile Leu Pro Lys 405 410 415 Gin Arg Ile Ser Asp Asn Gly Thr Leu Pro Tyr Gin Ile His Glu Ala 420 425 430 Glu Leu Glu Lys Ile Leu Glu Asn Gin Ala Lys Tyr Tyr Asp Phe Leu 435 440 445 Page 2171 of 3790 Asn His Glu Glu Asn Gly Ile Ser Thr Lys Asp Lys Leu Leu Met Thr 450 455 460 Phe Lys Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Tyr His 465 470 475 480 Lys Asn Lys Gly Gly Asn Ser Trp Ile Val Arg Lys Glu Glu Gly Lys 485 490 495 Ile Leu Pro Trp Asn Phe Glu Gin Lys Val Asp Ile Glu Lys Ser Ala 500 505 510 Glu Glu Phe Ile Lys Arg Met Thr Asn Lys Cys Thr Tyr Leu Asn Gly 515 520 525 Glu Asp Val Ile Pro Lys Asp Ser Phe Leu Tyr Ser Glu Tyr Ile Ile 530 535 540 Leu Asn Glu Leu Asn Lys Val Gin Val Asn Asp Glu Phe Leu Asn Lys 545 550 555 560 Glu Ile Lys Lys Lys Ile Ile Glu Asp Leu Phe Lys Lys Ser Lys Lys 565 570 575 Ile Ser Glu Lys Asn Phe Arg Glu Tyr Leu Leu Val Asn Gin Ile Thr 580 585 590 Asn Lys Thr Val Glu Leu Lys Gly Val Lys Asp Ala Phe Asn Ser Asn 595 600 605 Tyr Val Ser Tyr Ile Lys Phe Lys Asp Ile Phe Gly Asp Lys Leu Asn 610 615 620 Leu Asp Ile Tyr Lys Glu Ile Ser Glu Lys Ser Ile Leu Trp Lys Cys 625 630 635 640 Leu Tyr Gly Asp Asp Lys Lys Ile Phe Glu Lys Lys Ile Lys Ser Val 645 650 655 Tyr Gly Asp Ile Leu Thr Lys Asp Glu Ile Lys Lys Ile Asn Ser Phe 660 665 670 Lys Phe Asn Thr Trp Gly Arg Leu Ser Glu Lys Leu Leu Thr Glu Ile 675 680 685 Glu Phe Ile Asp Leu Glu Thr Gly Glu Cys Tyr Ser Ser Val Met Asp 690 695 700 Page 2172 of 3790 Ala Leu Arg Arg Thr Asn Tyr Asn Leu Met Glu Leu Leu Ser Ser Lys 705 710 715 720 Phe Thr Leu Gin Glu Asn Ile Asp Asn Glu Asn Lys Glu Val Ser Glu 725 730 735 Phe Ser Tyr Arg Asp Leu Val Glu Glu Ser Tyr Val Ser Pro Ser Leu 740 745 750 Lys Arg Ala Ile Leu Gin Thr Leu Lys Ile Tyr Glu Glu Ile Arg Lys 755 760 765 Ile Thr Gly Arg Ile Pro Lys Lys Val Phe Ile Glu Met Ala Arg Gly 770 775 780 Gly Asp Glu Thr Met Lys Asn Lys Lys Ile Pro Ala Arg Gin Glu Gin 785 790 795 800 Leu Lys Lys Leu Tyr Asp Ser Cys Gly Lys Asp Ile Ser Asn Phe Ser 805 810 815 Ile Asp Ile Lys Glu Met Lys Asn Ser Leu Asn Ser Tyr Asp Asn Asn 820 825 830 Ser Leu Arg Gin Lys Lys Leu Tyr Leu Tyr Tyr Leu Gin Phe Gly Lys 835 840 845 Cys Met Tyr Thr Gly Lys Glu Ile Asp Leu Asn Arg Leu Leu Gin Asn 850 855 860 Asn Asp Thr Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Val Ile 865 870 875 880 Lys Asp Asp Ser Phe Asp Asn Leu Val Leu Val Leu Lys Asn Glu Asn 885 890 895 Ala Glu Lys Ser Asn Glu Tyr Pro Leu Lys Lys Glu Ile Gin Glu Lys 900 905 910 Met Lys Ser Phe Trp Lys Phe Leu Lys Glu Lys Asn Phe Ile Ser Asp 915 920 925 Glu Lys Tyr Lys Arg Leu Thr Gly Lys Asp Glu Phe Glu Leu Arg Gly 930 935 940 Phe Met Ala Arg Gin Leu Val Asn Val Arg Gin Thr Thr Lys Glu Ala 945 950 955 960 Page 2173 of 3790 Ser Ile Val Ala Leu Asp Ser Asn Lys Leu Met Asp Phe Glu Asn 978 1391 PRT Galbibacter sp. 978 Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Lys 20 Glu Ala Glu Asn Glu Asn Glu Val 25 Ser Asp Ile 30 Ile Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Leu Thr Asn Page 2175 of 3790 40 45 Phe Glu Gly Gly Lys Ala Tyr Ser Asn Asn Ala Glu Arg Thr Leu Lys 50 55 60 Arg Gly Ala Arg Arg Asn Leu Gin Arg Tyr Lys Leu Arg Arg Glu Asn 65 70 75 80 Leu Ile Glu Ile Leu Leu Lys Asn Gly Leu Ile Asn Lys Asp Thr Ala 85 90 95 Leu Thr Glu Val Gly Lys Glu Thr Thr His Gin Thr Leu Lys Leu Arg 100 105 110 Ser Lys Ser Ala Asn Glu Lys Val Ser Leu Glu Asp Leu Ala Lys Ile 115 120 125 Leu Leu Ser Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Val 130 135 140 Asn Ala Glu Asp Asp Gly Val Ala Ile Asp Gly Met Glu Val Ala Lys 145 150 155 160 Leu Leu Tyr Asp Glu Asn Met Thr Pro Gly Glu Tyr Val Leu Arg Leu 165 170 175 Leu Glu Ser Gly Lys Lys His Leu Pro Asp Phe Tyr Arg Ser Asp Leu 180 185 190 Gin Glu Glu Phe Asn Leu Val Trp Lys Lys Gin Ser Glu Phe Tyr Pro 195 200 205 Leu Ile Leu Thr Lys Glu Leu Phe Phe Glu Leu His Gly Lys Asn Lys 210 215 220 Ser Gin Thr Trp Ala Ile Cys Lys Glu Pro Leu Gly Ile Val Gly Val 225 230 235 240 Lys Leu Lys Gly Ser Ala Lys Glu Gin Lys Phe Ala Arg Tyr Arg Leu 245 250 255 Arg Lys Glu Ala Leu Thr Gin Gin Ile Glu Leu Glu His Leu Ala Ile 260 265 270 Val Leu Gin Asp Ile Asn Asn Asp Ser Asn Lys Ser Ser Gly Tyr Leu 275 280 285 Page 2176 of 3790 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe Asn Lys Glu Thr 290 295 300 Val Gly Gin Tyr Gin Tyr Lys Gin Leu Gin Lys Asp Pro Asn Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Val Ile Trp Arg Asn Gin Ala Lys Phe Tyr Pro Gin Leu Thr Asn Glu 340 345 350 Leu Lys Gin Glu Ile Arg Asp Val Val Ile Phe Tyr Gin Arg Lys Leu 355 360 365 Lys Ser Gin Lys Asn Leu Ile Ser Phe Cys Gin Phe Glu Ser Thr Gin 370 375 380 Gin Asn Tyr Val Glu Lys Glu Thr Gly Lys Thr Lys Ile Arg Thr Ile 385 390 395 400 Gly Arg Arg Val Ile Pro Arg Ser Ser Pro Leu Phe Gin Glu Phe Lys 405 410 415 Ile Trp Gin Ser Leu Asn Asn Leu Lys Phe Val Asn Ser Glu Ser Asn 420 425 430 Gin Ile Ile Gin Phe Ile Glu Leu Glu Asp Asp Val Lys Lys Val Val 435 440 445 Phe Asp Glu Leu Asn Leu Arg Gly Asp Leu Lys Pro Asn Gin Val Leu 450 455 460 Lys Ile Leu Ser Lys Tyr Met Lys Ile Gly Lys Leu Thr Gin Trp Lys 465 470 475 480 Cys Asn Leu Glu Glu Ile Glu Gly Asn Arg Thr Asn Ser Ala Leu Tyr 485 490 495 Asn Val Phe Gin Met Ile Ala Glu Glu Glu Gly Tyr Gly Phe Asn Trp 500 505 510 Gly Lys Lys Ser Ala Leu Glu Ile Lys Ser Glu Leu Lys Ala Ile Phe 515 520 525 Ser Ser Ile Gly Ile Asn Asp Ser Ile Leu Asp Phe Asp Phe Ser Lys 530 535 540 Page 2177 of 3790 Lys Leu Asp Gin Gin Leu Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser 545 550 555 560 Ala Glu Glu Gly Asn Ser Lys Ile Thr Glu Glu Asp Lys Phe Thr Tyr 565 570 575 Gly Asn Thr Gly Val Ala Leu Lys Lys Lys Leu His Leu Lys Phe Gly 580 585 590 Phe Lys Pro Glu Tyr Ser Thr Leu Ile Ser Asn Leu Arg Phe Thr Ser 595 600 605 Asp Tyr Gly Asn Leu Ser Ser Lys Ala Ile Ser Lys Ile Leu Pro Phe 610 615 620 Leu Arg Asp Gly Ser Asp Tyr Ser Lys Ala Cys Gin Tyr Ala Gly Tyr 625 630 635 640 Asn His Ser Asn Ser Leu Ser Ala Asp Glu Leu Asp Asn Arg Glu Leu 645 650 655 Lys Pro Lys Leu Glu Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val 660 665 670 Val Glu Lys Ile Leu Asn Gin Met Val Asn Val Val Asn Gin Val Ile 675 680 685 Asp Asn Tyr Gly Lys Pro Asp Glu Val Arg Ile Glu Leu Ala Arg Glu 690 695 700 Leu Lys Lys Ser Ala Lys Glu Arg Ser Gin Met Thr Lys Asn Ile Ser 705 710 715 720 Asp Ala Thr Arg Arg Asn Ala Glu Ile Lys Lys Tyr Leu Ser Lys Glu 725 730 735 Phe Gly Ile Pro Asn Pro Thr Lys Gly Asp Val Ile Arg Tyr Arg Leu 740 745 750 Trp Glu Glu Leu Ala Ser Asn Gly Tyr Lys Asp Leu Phe Arg Asp Lys 755 760 765 Tyr Ile Pro Lys Glu Lys Leu Phe Ser Asn Glu Ile Asp Ile Glu His 770 775 780 Ile Ile Pro Lys Ala Leu Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr 785 790 795 800 Page 2178 of 3790 Ser Val Asn Lys Thr Lys Leu Lys Gly Lys Asp Asn Tyr Asn Lys Page 2180 of 3790 979 1186 PRT Gardnerella vaginalis 979 Met Glu Gly Asn Ile Ser Tyr Ala Ile Gly Ile Asp Val Gly Leu Asn 15 10 15 Ser Val Gly Leu Ala Ala Ile Arg Leu Asp Asp Tyr Gly Glu Pro Ile 20 25 30 Arg Ile Leu Lys Ala Met Ser Val Ile His Asp Ala Gly Ile Asp Pro 35 40 45 Asn Gly Ala Lys Glu Ser Asp Thr Arg Lys Ala Ile Ser Gly Val Ala 50 55 60 Arg Arg Val Arg Arg Leu Tyr Arg Gin Arg Arg Arg Arg Leu Gin Lys 65 70 75 80 Leu Asp Phe Leu Leu Gin Ser Leu Gly Trp Pro Val Val Glu Asn Lys 85 90 95 Page 2181 of 3790 Asp Leu Asp Phe Ser Asp Ser Phe Ile Pro Trp Ile Phe Arg Ala Lys 100 105 110 Leu Ala Asp Glu Tyr Ile Ala Asp Glu Glu Gin Arg Lys Gin Met Leu 115 120 125 Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 130 135 140 Tyr Gin Ser Ile Lys Ser Met Met Gin Glu Thr Glu Tyr Ser Glu Phe 145 150 155 160 Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Leu Ala Pro Gly Val Gly 165 170 175 Cys Glu Gly Ser Thr Pro Ala Gin Leu Val Arg Asp Tyr Leu Leu Ser 180 185 190 Gin Gin Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Gly Gly Arg 195 200 205 Arg Lys Asn His Pro His Ser Leu Asp Pro Val Leu Pro Arg Lys Leu 210 215 220 Met Gin Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gin 225 230 235 240 His Ile Asp Asp Lys Tyr Val Arg Glu Gin Ile Ile Asn Ala Val Phe 245 250 255 Tyr Ala Glu Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 260 265 270 Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 275 280 285 Gin Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 290 295 300 Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gin Asn Val Tyr 305 310 315 320 Lys Leu Leu Thr Thr Ser Ile Asp Lys Ser Ser Lys Arg Lys Ser Ala 325 330 335 Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 340 345 350 Page 2182 of 3790 Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gin Ile Gly Asp Gly Glu 355 360 365 Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Leu 370 375 380 Tyr Ala Asn Asn Lys Ser Leu Gly Gin Ser Leu Ile Thr Trp Trp Leu 385 390 395 400 Ala Ser Asn Arg Thr Gin Glu Asp Lys Glu Ala Leu Ile Glu Ile Leu 405 410 415 Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gin 420 425 430 Asp Lys Tyr Gly Ser Ala Ile Ala Phe Ile Asp Ser Met Asn Glu Thr 435 440 445 Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asp Gly Arg Ala Ala 450 455 460 Tyr Ser Leu Glu Thr Leu Asp Glu Leu Asn Lys Gin Met Leu Glu Thr 465 470 475 480 Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 485 490 495 Asn Trp Arg Pro Ala Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 500 505 510 Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 515 520 525 Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 530 535 540 Ser Gly Phe Gin Ser Lys Lys Met Ala Asn Ser Tyr Lys Glu Leu Leu 545 550 555 560 Asp Lys Arg Thr Glu Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn 565 570 575 Ser Leu His Leu Gly Thr Ser Asp Ser Ile Ser Asp Ala Asp Ile Arg 580 585 590 Arg Tyr Glu Ala Val Gin Arg Gin Asn Gly Gin Cys Leu Tyr Cys Gly 595 600 605 Page 2183 of 3790 Ser Glu Ile Thr Tyr His Thr Cys Glu Leu Asp His Ile Val Pro Arg 610 615 620 Lys Gly Pro Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Thr Cys 625 630 635 640 Ser Ser Cys Asn Ala Gin Lys Cys Asn Thr Pro Phe Ala Thr Trp Cys 645 650 655 Glu Gin Ser Thr Tyr Cys Lys Asn His Asp Ile Ser Ala Asp Ser Ala 660 665 670 Ile Asn Arg Val Arg Ala Phe Ile Phe Pro Pro Asn Ser Tyr Asp Lys 675 680 685 Arg Gly Ala Asn Gin Phe Lys Lys Glu Val Ile Ala Arg Leu Lys Gin 690 695 700 Lys Val Gly Asp Glu Ala Phe Asp Asn Arg Ser Ile Glu Ser Val Ala 705 710 715 720 Trp Met Ala Asn Glu Leu His Arg Arg Ile Asp Trp Tyr Tyr Asn Ser 725 730 735 Gin Asn Tyr Gin Thr Asn Asn Gly Ile Ser Asp Ile Ser Asn Lys Ala 740 745 750 Gin Thr Asn Val Gly Val Tyr Ala Gly Ser Leu Thr Ala Ile Ala Arg 755 760 765 Arg Met Ser Gly Ile Asp Gly Lys Leu Glu Phe Phe Asp Gly Arg Arg 770 775 780 Lys Thr Arg Phe Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile 785 790 795 800 Ala Met Met Thr Pro Gly Ile Ala Gin Ile Leu Ala Ile Lys Cys Asn 805 810 815 Leu Arg Glu Thr Gin Leu Leu Gin Gly Asn Lys Val Val Pro Gly Gly 820 825 830 Ile Asp Trp Lys Glu Tyr Pro Thr Ala Asn Asp Gin Gly Tyr Gin Gin 835 840 845 Tyr Ala Asn Trp Ser Val Arg Met Asn Ala Leu Leu Lys Leu Leu Asn 850 855 Page 2184 of 3790 860 Glu Glu Met Arg Ala Asp Arg Ile Ala Val Val Asn Ser Ile Arg Leu 865 870 875 880 Arg Tyr Ser Asn Ser Ser Val His Gin Tyr Glu Val Asn Ala Leu Leu 885 890 895 Lys Leu His Val Gly Asp Glu Ile Asp Ser Glu Thr Ile Arg Arg Ser 900 905 910 Ser Thr Pro Ala Leu Tyr Cys Ala Leu Thr Arg Asn Pro Asp Tyr Asp 915 920 925 Val Asn Asn Gly Phe Pro Glu Asn Pro Gly Arg Thr Ile Leu Leu His 930 935 940 Asn Lys Lys Leu Asn Ala Asp Asp Ser Ile Thr Phe Phe Lys Ala Gin 945 950 955 960 Ala Val Gin Leu Phe Val Arg Glu Gly Ser Ala Lys Ile Gly Asn Ser 965 970 975 Ile His His Leu Arg Ile Tyr Glu Tyr Phe Glu Lys Leu Lys Ser Gly 980 985 990 Lys Ile Lys Lys Ser Tyr Gly Met Ile Arg Val Phe Gin Asn Asp Leu 995 1000 1005 Page 2185 of 3790 980 1186 PRT Gardnerella vaginalis 980 Page 2186 of 3790 Ser Val Ala Ile Arg His Ile Ala Arg His Arg Gly Trp Arg Asn Pro 130 135 140 Tyr Gin Ser Ile Lys Ser Met Thr Gin Glu Thr Glu Tyr Ser Glu Phe 145 150 155 160 Tyr Asn Glu Leu Leu Lys Asn Ile Glu Lys Phe Ala Pro Gly Val Gly 165 170 175 Cys Glu Gly Ser Thr Pro Ala Gin Leu Val Arg Asp Tyr Leu Leu Leu 180 185 190 Gin Gin Gly Lys Ala Ser Arg Arg Leu Arg Ile Thr Thr Asp Glu Lys 195 200 205 Arg Lys Asn His Pro Asn Ser Leu Asn Pro Ile Leu Pro Arg Lys Leu 210 215 220 Met Gin Ser Asp Asn Met Leu Glu Ile Leu Asn Ile Phe Asn Val Gin 225 230 235 240 His Ile Asp Asp Lys Tyr Val Arg Glu Gin Ile Ile Asn Ala Val Phe 245 250 255 Tyr Ala Lys Ser Pro Arg Gly Ser Ala Glu Asn Arg Val Gly Lys Asp 260 265 270 Ala Ile Thr Gly Lys Gly Lys Arg Ala Leu Lys Ala Ser Leu Ala Phe 275 280 285 Gin Lys Tyr Arg Ile Ile Ser Thr Ile Ser Asn Leu Arg Ile Arg Glu 290 295 300 Asn Ser Lys Glu Arg Cys Leu Thr Ile Glu Glu Lys Gin Ser Val Tyr 305 310 315 320 Lys Leu Leu Thr Thr Ser Thr Asp Glu Ser Ser Lys Glu Lys Ser Ala 325 330 335 Glu Ala Pro Leu Tyr Thr Trp Ile Asp Val Ala Asp Cys Leu Gly Ile 340 345 350 Glu Arg Tyr Lys Leu Arg Gly Val Gly Ser Gin Ile Gly Asp Gly Glu 355 360 365 Ser Val Gly Asn Arg Pro Pro Met Leu Asn Ser Glu Leu Ala Ile Ile 370 375 380 Page 2187 of 3790 Tyr Ala Asn Asn Lys Ser Leu Gly Lys Ser Leu Leu Thr Trp Trp Leu 385 390 395 400 Asp Ala Asn Arg Thr Gin Glu Asp Lys Glu Ala Leu Ile Glu Ile Leu 405 410 415 Ser Asn Thr Val Asp Ile Glu Ala Ile His Asp Asn Pro Glu Tyr Gin 420 425 430 Asp Lys Tyr Gly Ser Ala Ile Ala Phe Ile Asp Ser Met Asp Glu Thr 435 440 445 Glu Ile Ala Ala Leu Glu Asn Ile Ser Leu Pro Asp Gly Arg Ala Ala 450 455 460 Tyr Ser Leu Glu Thr Leu Asp Lys Leu Asn Lys Gin Met Leu Glu Thr 465 470 475 480 Asp Asp Asp Leu Phe Glu Ala Arg Lys Lys Leu Phe Asn Leu Pro Asn 485 490 495 Asn Trp Arg Pro Ser Glu Ala Pro Ile Ala Glu Pro Thr Gly Asn Pro 500 505 510 Ser Val Asp Arg Val Leu Lys Ile Val His Arg Phe Leu Ile Ser Ala 515 520 525 Lys Asn Arg Trp Gly Asn Pro Glu Arg Ile Asn Ile Glu His Val Arg 530 535 540 Ser Gly Phe Lys Ser Lys Lys Met Ala Asn Ser Tyr Lys Glu Leu Leu 545 550 555 560 Asp Lys Arg Thr Lys Gly Lys Glu Asn Leu Lys Ala Met Met Arg Asn 565 570 575 Ser Leu His Leu Gly Met Ser Asp Ser Ile Ser Asp Ala Asp Ile Arg 580 585 590 Arg Tyr Glu Ala Val Gin Arg Gin Asn Gly Gin Cys Leu Tyr Cys Gly 595 600 605 Ser Glu Ile Thr Tyr His Thr Cys Glu Leu Asp His Ile Val Pro Arg 610 615 620 Lys Gly Pro Gly Ser Thr Asn Thr Arg Glu Asn Leu Val Ala Thr Cys 625 630 635 640 Page 2188 of 3790 Ser Leu Cys Asn Ala Gin Lys Cys Asn Thr Pro Phe Ser Thr Trp Cys 645 650 655 Glu Gin Ser Thr Tyr Cys Lys Asn His Asp Ile Ser Val Asp Ser Ala 660 665 670 Ile Asn Arg Val Arg Ala Phe Ile Phe Pro Pro Asn Ser Tyr Asp Lys 675 680 685 Arg Gly Ala Asn Gin Phe Lys Lys Glu Val Ile Ala Arg Leu Lys Gin 690 695 700 Lys Val Gly Asp Glu Ala Phe Asp Asn Arg Ser Ile Glu Ser Val Ala 705 710 715 720 Trp Met Ala Asn Glu Leu His Arg Arg Ile Asp Trp Tyr Tyr Asn Ser 725 730 735 Gin Asn Tyr Gin Thr Asn Asn Gly Ile Ser Asp Ile Thr Asn Lys Ala 740 745 750 Gin Thr Asn Val Gly Val Tyr Ala Gly Ser Leu Thr Ala Ile Ala Arg 755 760 765 Arg Met Ser Gly Ile Asp Gly Lys Leu Glu Phe Phe Asp Gly Arg Arg 770 775 780 Lys Thr Arg Phe Asp Arg Arg His His Ala Val Asp Ala Ser Val Ile 785 790 795 800 Ala Met Met Thr Pro Gly Ile Ala Gin Ile Leu Ala Ile Lys Cys Asn 805 810 815 Leu Arg Glu Thr Gin Leu Leu Gin Gly Asn Lys Val Val Pro Gly Gly 820 825 830 Ile Asp Trp Lys Glu Tyr Pro Thr Ala Asn Asp Gin Gly Tyr Gin Gin 835 840 845 Tyr Ala Asn Trp Ser Val Arg Met Asn Ala Leu Leu Lys Leu Leu Asn 850 855 860 Glu Glu Met Arg Ala Asp Arg Ile Ala Val Val Asn Ser Ile Arg Leu 865 870 875 880 Arg Tyr Asn Asn Ser Ser Val His Gin Tyr Lys Val Asn Ala Leu Leu 885 895 Page 2189 of 3790 890 Lys Leu Tyr Ser Asn Cys Lys Arg Asn Asn Phe Asp Tyr Ser Ser 1115 1120 1125 Page 2190 of 3790 981 1258 PRT Gemella haemolysans 981 Tyr Ile Glu Leu Leu Asp Leu Ala Lys Leu Val Tyr Asp Ser Ile Ile 145 150 155 160 Page 2191 of 3790 Leu Ser Asp Ile Lys Lys Glu Gly Lys Thr Leu Ser Glu Ser Lys Val 165 170 175 Glu Leu Tyr His Lys His Arg Glu Asp Leu Thr Lys Leu Lys Thr Leu 180 185 190 Val Lys Asn Asp Ser Lys Leu Ser Glu Asp Lys Lys Val Glu Leu Tyr 195 200 205 Ser Ala Ile Phe Lys Glu Asp Lys Asp Lys Gly Thr Asn Tyr Val Asn 210 215 220 Tyr Ile Arg Lys Ser Glu Glu Gly Lys Gly Cys Asn Tyr Glu Asp Phe 225 230 235 240 Lys Lys Phe Leu Val Lys Glu Leu Ala Lys Leu Glu Glu Ser Ser Ala 245 250 255 Lys Glu Glu Ile Leu Arg Asp Leu Glu Leu Glu Leu Phe Leu Pro Leu 260 265 270 Gin Arg Thr Lys Asp Asn Ser Val Val Pro Tyr Gin Ile His Lys Glu 275 280 285 Glu Leu Val Lys Ile Leu Asp Asn Ala Ala Lys Tyr His Lys Phe Leu 290 295 300 Asn Glu Lys Asp Asp Ser Gly Tyr Ser Ile Ile Glu Lys Val Ile Gin 305 310 315 320 Leu Leu Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Ser Ser 325 330 335 Lys Lys Ala Lys Val Asp Gly Phe Ala Trp Ser Val Arg Asn Lys Gly 340 345 350 Tyr Glu Asn Thr Pro Val Thr Pro Trp Asn Tyr Glu Lys Val Ile Asp 355 360 365 Glu Ser Ala Ser Ala Glu Lys Phe Ile Thr Asn Leu Thr Asn Lys Cys 370 375 380 Thr Tyr Leu Lys Gly Glu Asp Val Leu Pro Lys Ser Ser Leu Leu Tyr 385 390 395 400 Ser Glu Phe Ala Leu Leu Asn Glu Leu Asn Ala Leu Lys Tyr Asp Gly 405 410 415 Page 2192 of 3790 Asn Arg Ile Ser Leu Glu Ala Arg Asn Val Ile Ile Glu Lys Leu Phe 420 425 430 Lys Glu Gin Gly Lys Lys Val Thr Lys Thr Ser Ile Lys Asn Leu Leu 435 440 445 Lys Ala Glu Gly Tyr Ile Asp Gly Lys Gly Glu Ile Thr Gly Ile Asp 450 455 460 Ile Thr Val Lys Asn Asp Leu Lys Ser Tyr Arg Asp Phe Lys Lys Ile 465 470 475 480 Leu Gly Asp Lys Phe Asn Thr Glu His Val Glu Asn Ile Ile Leu Trp 485 490 495 Ile Thr Leu Tyr Gly Glu Ser Arg Lys Leu Ile Lys Ala Lys Ile Glu 500 505 510 Ala Val Tyr Gly Asp Ile Tyr Ser Lys Glu Glu Ile Ala Lys Met Ser 515 520 525 Arg Leu Val Tyr Lys Asp Trp Gly Arg Phe Ser Arg Lys Leu Leu Thr 530 535 540 Glu Leu Val Ser Lys Lys Leu Tyr Asn Glu Glu Thr Gly Glu Cys Leu 545 550 555 560 Asn Ile Ile Gly Ala Met Arg Gin Asn Asn Ile Leu Phe Met Glu Leu 565 570 575 Leu Ala Asp Arg Phe Asp Tyr Ser Gin Gin Ile Ile Asp Tyr Asn Lys 580 585 590 Glu Leu Gin Lys Glu Val Thr Glu Ile Thr Pro Glu Ile Leu Asp Asp 595 600 605 Leu Tyr Val Ser Pro Ser Val Lys Arg Ser Ile Trp Gin Thr Val Arg 610 615 620 Ile Val Glu Glu Leu Lys Lys Ile Ile Gly Cys Ala Pro Ala Lys Ile 625 630 635 640 Phe Val Glu Thr Thr Arg Ser Asn Gin Asp Lys Lys Lys Pro Thr Asp 645 650 655 Ser Arg Lys Lys Gin Leu Glu Leu Phe Tyr Lys Ala Val Lys Lys Asp 660 665 670 Page 2193 of 3790 Val Lys Asp Leu Glu Lys Glu Ile Gly Ser Leu Asn Phe Asp Lys Leu 675 680 685 Asn Glu Arg Leu Ser Ser Val Glu Pro Ser Lys Leu Lys Ala Lys Lys 690 695 700 Leu Tyr Leu Tyr Tyr Thr Gin Leu Gly Arg Cys Met Tyr Ser Gly Glu 705 710 715 720 Thr Ile Asp Ile Thr Gin Leu Asn Thr Thr Ala Tyr Asp Ile Asp His 725 730 735 Ile Tyr Pro Gin Ser Lys Val Lys Asp Asp Ser Phe Thr Asn Thr Val 740 745 750 Leu Val Lys Arg Glu Tyr Asn Ala Ala Lys Thr Asp Arg Tyr Pro Leu 755 760 765 Gly Ser Asp Ile Gin Thr Pro Ser Asn Arg Arg Phe Trp Lys Phe Leu 770 775 780 Lys Glu Lys Gly Leu Ile Thr Asp Glu Lys Tyr Asn Arg Leu Val Arg 785 790 795 800 Thr Glu Glu Phe Ser Asp Glu Glu Leu Thr Gly Phe Ile Ala Arg Gin 805 810 815 Leu Val Glu Thr Ser Gin Ser Val Lys Ala Val Ala Gly Ile Leu Gly 820 825 830 Glu Leu Asn Pro Lys Thr Ser Ile Cys Tyr Ser Lys Ala Glu Asn Val 835 840 845 Ser Ser Phe Arg Gin Asn Phe Gly Lys Ile Lys Glu Gly Asn Arg Lys 850 855 860 Ser Asp Asn Thr Glu Gin Leu Ile Lys Val Arg Glu Ile Asn Asp Tyr 865 870 875 880 His His Ala Lys Asp Ala Tyr Leu Asn Val Val Val Gly Asn Val Tyr 885 890 895 Asp Thr Lys Phe Thr Arg Asn Val Phe Asn Phe Ile Lys Asp Lys Lys 900 905 910 Asp Gly Arg Lys Tyr Ser Leu Asn Asn Val Phe Tyr Glu Asn Val Ser Page 2194 of 3790 982 1054 PRT Haemophilus parainfluenzae 982 Met Glu Asn Lys Asn Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 15 10 15 Ala Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro 20 25 30 Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Val 35 40 45 Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 50 55 60 Ala Arg Arg Leu Thr Gin Arg Arg Val Ala Arg Leu Lys Lys Ala Lys 65 70 75 80 Arg Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Arg Leu 85 90 95 Pro His Gin Val Trp Gin Leu Arg Val Glu Gly Leu Asp His Lys Leu 100 105 110 Page 2196 of 3790 Glu Arg Gin Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg 115 120 125 Gly Tyr Leu Ser Gin Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu 130 135 140 Leu Gly Ala Leu Leu Ser Gly Val Asp Asn Asn His Lys Leu Leu Gin 145 150 155 160 Gin Ala Thr Tyr Arg Ser Pro Ala Glu Leu Ala Val Lys Lys Phe Glu 165 170 175 Val Glu Glu Gly His Ile Arg Asn Gin Gin Gly Ala Tyr Thr His Thr 180 185 190 Phe Ser Arg Leu Asp Leu Leu Ala Glu Met Glu Leu Leu Phe Ser Arg 195 200 205 Gin Gin His Phe Gly Asn Pro Phe Ala Ser Glu Lys Leu Leu Glu Asn 210 215 220 Leu Thr Ala Leu Leu Met Trp Gin Lys Pro Ala Leu Ser Gly Glu Ala 225 230 235 240 Ile Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asp Glu Tyr Lys Ala 245 250 255 Ala Lys Asn Thr Tyr Ser Ala Glu Arg Phe Val Trp Ile Thr Lys Leu 260 265 270 Asn Asn Leu Arg Ile Gin Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp 275 280 285 Asn Glu Arg Leu Ala Leu Met Glu Gin Pro Tyr Asp Lys Asn Arg Leu 290 295 300 Phe Tyr Ser Gin Val Arg Ser Ile Leu Lys Leu Ser Asp Glu Ala Ile 305 310 315 320 Phe Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Ala Ile Glu Thr 325 330 335 Lys Ala Val Leu Met Glu Met Lys Ala Tyr His Gin Ile Arg Lys Val 340 345 350 Leu Glu Gly Asn Asn Leu Lys Ala Glu Trp Ala Glu Leu Lys Ala Asn 355 360 365 Page 2197 of 3790 Pro Thr Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr 370 375 380 Asp Glu Asp Ile Ser Ala Tyr Leu Ala Gly Lys Leu Ser Gin Pro Val 385 390 395 400 Leu Asn Ala Leu Leu Glu Asn Leu Ser Phe Asp Lys Phe Ile Gin Leu 405 410 415 Ser Leu Lys Ala Leu Tyr Lys Leu Leu Pro Leu Met Gin Gin Gly Leu 420 425 430 Arg Tyr Asp Glu Ala Cys Arg Glu Ile Tyr Gly Asp His Tyr Gly Lys 435 440 445 Lys Thr Glu Glu Asn His His Phe Leu Pro Gin Ile Pro Ala Asp Glu 450 455 460 Ile Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gin Ala Arg Lys Val 465 470 475 480 Ile Asn Gly Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile His Ile 485 490 495 Glu Thr Gly Arg Glu Val Gly Lys Ser Tyr Lys Asp Arg Arg Glu Leu 500 505 510 Glu Lys Arg Gin Glu Glu Asn Arg Lys Gin Arg Glu Asn Ala Ile Lys 515 520 525 Glu Phe Lys Glu Tyr Phe Pro His Phe Ala Gly Glu Pro Lys Ala Lys 530 535 540 Asp Ile Leu Lys Met Arg Leu Tyr Lys Gin Gin Asn Ala Lys Cys Leu 545 550 555 560 Tyr Ser Gly Lys Pro Ile Glu Leu His Arg Leu Leu Glu Lys Gly Tyr 565 570 575 Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser 580 585 590 Phe Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gin Asn Lys Gly 595 600 605 Asn Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys His Asn Ser Glu Arg 610 615 620 Page 2198 of 3790 Trp Arg Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Ala 625 630 635 640 Lys Lys Gin Arg Ile Leu Ser Gin Lys Leu Asp Glu Lys Gly Phe Ile 645 650 655 Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn 660 665 670 Phe Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val 675 680 685 Phe Ala Ser Asn Gly Gin Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly 690 695 700 Leu Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala 705 710 715 720 Val Val Val Ala Cys Ser Thr Val Ala Met Gin Gin Lys Ile Thr Arg 725 730 735 Phe Val Arg Phe Glu Ala Gly Asp Val Phe Thr Gly Glu Arg Ile Asp 740 745 750 Arg Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Thr Pro Trp Gin 755 760 765 Phe Phe Lys Gin Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys 770 775 780 Leu Glu Leu Glu Asn Arg Leu Pro Asp Arg Pro Gin Ala Asn His Glu 785 790 795 800 Phe Val Gin Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr 805 810 815 Gly Gin Gly His Met Glu Thr Val Lys Ser Ala Lys Arg Leu Asn Glu 820 825 830 Gly Ile Ser Val Ile Lys Met Pro Leu Thr Lys Leu Lys Leu Lys Asp 835 840 845 Leu Glu Leu Met Val Asn Arg Glu Arg Glu Lys Asp Leu Tyr Asp Thr 850 855 860 Leu Lys Ala Arg Leu Glu Ala Phe Asn Asp Asp Pro Ala Lys Ala Phe 880 865 870 Page 2199 of 3790 875 Arg 983 1052 PRT Haemophilus parainfluenzae] 983 Met Lys Asn Thr Ser Leu Asn Tyr Val Leu Gly Leu Asp Leu Gly Ile 15 10 15 Ser Ser Val Gly Trp Ala Val Val Glu Ile Asp Glu Lys Glu Asn Pro Page 2200 of 3790 25 30 Leu Ser Leu Ile Asp Val Gly Val Arg Thr Phe Glu Arg Ala Glu Thr 35 40 45 Gin Lys Gly Glu Ser Leu Ala Leu Ala Arg Arg Leu Ala Arg Ser Ala 50 55 60 Arg Arg Leu Thr Gin Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 65 70 75 80 Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Cys Leu Pro 85 90 95 His Gin Val Trp Gin Leu Arg Val Glu Gly Leu Glu Arg Lys Leu Glu 100 105 110 Arg Gin Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 115 120 125 Tyr Leu Ser Gin Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 130 135 140 Gly Ala Leu Leu Ser Gly Val Ala Asn Asn His Lys Leu Leu Gin Gin 145 150 155 160 Thr Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 165 170 175 Glu Glu Gly His Ile Arg Asn Gin Gin Gly Ser Tyr Thr His Thr Phe 180 185 190 Ser Arg Leu Asp Leu Leu Ser Glu Met Glu Leu Leu Phe Ser Arg Gin 195 200 205 Gin His Phe Gly Asn Pro Phe Thr Ser Glu Lys Leu Leu Glu Asn Leu 210 215 220 Thr Ala Leu Leu Met Trp Gin Lys Pro Ala Leu Ser Gly Asp Ala Ile 225 230 235 240 Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asn Glu Tyr Lys Ala Ala 245 250 255 Lys His Thr Tyr Ser Ala Glu Arg Phe Ile Trp Ile Thr Lys Leu Asn 260 265 270 Page 2201 of 3790 Asn Leu Arg Ile Gin Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp Asn 275 280 285 Glu Arg Leu Ala Leu Met Lys Gin Pro Tyr Glu Lys Ala Lys Leu Thr 290 295 300 Tyr Ala Gin Val Arg Ser Ile Leu Asn Leu Ser Asp Glu Ala Ile Phe 305 310 315 320 Lys Gly Leu Arg Tyr Ser Gly Glu Asp Lys Lys Thr Ser Glu Thr Lys 325 330 335 Thr Val Leu Met Glu Met Lys Ala Tyr His Gin Ile Arg Leu Ala Leu 340 345 350 Glu Lys Asn Asp Leu Lys Thr Glu Trp Ala Glu Leu Lys Val Asn Ser 355 360 365 Ser Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 370 375 380 Glu Asp Ile Ser Thr Cys Leu Ala Gly Lys Leu Ser Gin Pro Val Leu 385 390 395 400 Asn Ala Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile Gin Leu Ser 405 410 415 Leu Lys Ala Leu His Lys Ile Leu Pro Leu Met Gin Gin Gly Leu Arg 420 425 430 Tyr Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys 435 440 445 Thr Glu Glu Asn His Leu Leu Leu Pro Gin Ile Pro Ala Asp Glu Ile 450 455 460 Arg Asn Pro Val Val Leu Arg Thr Leu Thr Gin Ala Arg Lys Val Ile 465 470 475 480 Asn Gly Val Val Arg Leu Tyr Ser Ser Pro Ala Arg Ile His Ile Glu 485 490 495 Thr Gly Arg Glu Val Gly Lys Ser Tyr Gin Asp Arg Arg Glu Leu Glu 500 505 510 Lys Arg Gin Glu Glu Asn Arg Lys Gin Arg Glu Lys Ala Ile Ser Glu 515 520 525 Page 2202 of 3790 Ile Lys Thr Leu Phe Pro Asn Phe Ser Gly Glu Pro Lys Ala Lys Asp 530 535 540 Ile Leu Lys Met Arg Leu Tyr Tyr Gin Gin Asn Ala Lys Cys Leu Tyr 545 550 555 560 Ser Gly Lys Pro Leu Glu Leu His Arg Leu Leu Glu Gin Gly Tyr Val 565 570 575 Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 580 585 590 Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gin Asn Lys Gly Asn 595 600 605 Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 610 615 620 Lys Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Thr Lys 625 630 635 640 Lys Gin Arg Ile Leu Ser Gin Lys Leu Asp Glu Lys Gly Phe Ile Glu 645 650 655 Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 660 665 670 Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 675 680 685 Ala Ser Asn Gly Gin Ile Thr Ala Leu Leu Arg Gly Arg Trp Gly Leu 690 695 700 Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 705 710 715 720 Val Val Ala Cys Ser Thr Val Ser Met Gin Gin Lys Ile Thr Arg Phe 725 730 735 Val Arg Phe Glu Glu Gly Asn Val Phe Thr Gly Glu Arg Ile Asp Arg 740 745 750 Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ala Pro Trp Lys Phe 755 760 765 Phe Arg Glu Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 770 775 780 Page 2203 of 3790 Leu Ala Leu Ser Phe Glu Lys Tyr Gin Val Asp Glu Leu Gly Lys 1025 Page 2204 of 3790 1030 1035 Asn Ile Arg Leu Cys Lys Ser Ser Lys Arg Gin Ala Val Arg 1040 1045 1050 984 121 PRT Haemophilus pittmaniae 984 Page 2205 of 3790 Page 2206 of 3790 Arg Arg Leu Thr Gin Arg Arg Val Ala Arg Leu Lys Lys Ala Lys Arg 65 70 75 80 Leu Leu Lys Ser Glu Asn Ile Leu Leu Ser Thr Asp Glu Cys Leu Pro 85 90 95 His Gin Val Trp Gin Leu Arg Val Glu Gly Leu Glu Arg Lys Leu Glu 100 105 110 Arg Gin Glu Trp Ala Ala Val Leu Leu His Leu Ile Lys His Arg Gly 115 120 125 Tyr Leu Ser Gin Arg Lys Asn Glu Ser Lys Ser Glu Asn Lys Glu Leu 130 135 140 Gly Ala Leu Leu Ser Gly Val Ala Asn Asn His Lys Leu Leu Gin Gin 145 150 155 160 Thr Thr Tyr Arg Thr Pro Ala Glu Leu Ala Val Lys Lys Phe Glu Val 165 170 175 Glu Glu Gly His Ile Arg Asn Gin Gin Gly Ser Tyr Thr His Thr Phe 180 185 190 Ser Arg Leu Asp Leu Leu Ser Glu Met Glu Leu Leu Phe Ser Arg Gin 195 200 205 Gin His Phe Gly Asn Pro Phe Thr Ser Glu Lys Leu Leu Glu Asn Leu 210 215 220 Thr Ala Leu Leu Met Trp Gin Lys Pro Ala Leu Ser Gly Asp Ala Ile 225 230 235 240 Leu Lys Met Leu Gly Lys Cys Thr Phe Glu Asn Glu Tyr Lys Ala Ala 245 250 255 Lys His Thr Tyr Ser Ala Glu Arg Phe Ile Trp Ile Thr Lys Leu Asn 260 265 270 Asn Leu Arg Ile Gin Glu Asn Gly Leu Glu Arg Ala Leu Asn Asp Asn 275 280 285 Glu Arg Leu Ala Leu Met Lys Gin Pro Tyr Glu Lys Ala Lys Leu Thr 290 295 300 Tyr Ala Gin Val Arg Ser Ile Leu Asn Leu Ser Asp Glu Ala Ile Phe Page 2208 of 3790 Ser Gly Lys Pro Leu Glu Leu His Arg Leu Leu Glu Gin Gly Tyr Val 565 570 575 Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 580 585 590 Asn Asn Lys Val Leu Val Leu Ala Asn Glu Asn Gin Asn Lys Gly Asn 595 600 605 Leu Thr Pro Phe Glu Trp Leu Asp Gly Lys Asn Asn Ser Glu Arg Trp 610 615 620 Lys Ala Phe Lys Ala Leu Val Glu Thr Ser Ala Phe Pro Tyr Thr Lys 625 630 635 640 Lys Gin Arg Ile Leu Ser Gin Lys Leu Asp Glu Lys Gly Phe Ile Glu 645 650 655 Arg Asn Leu Asn Asp Thr Arg Tyr Val Ala Arg Phe Leu Cys Asn Phe 660 665 670 Ile Ala Asp Asn Met His Leu Thr Gly Glu Gly Lys Arg Lys Val Phe 675 680 685 Ala Ser Asn Gly Gin Ile Thr Ala Leu Leu Arg Gly Arg Trp Gly Leu 690 695 700 Ala Lys Ser Arg Glu Asp Asn Asp Arg His His Ala Leu Asp Ala Val 705 710 715 720 Val Val Ala Cys Ser Thr Val Ser Met Gin Gin Lys Ile Thr Arg Phe 725 730 735 Val Arg Phe Glu Glu Gly Asn Val Phe Thr Gly Glu Arg Ile Asp Arg 740 745 750 Glu Thr Gly Glu Ile Ile Pro Leu His Phe Pro Ala Pro Trp Lys Phe 755 760 765 Phe Arg Glu Glu Val Glu Ile Arg Ile Phe Ser Asp Asn Pro Lys Leu 770 775 780 Glu Leu Glu Asn Arg Leu Ile Ala Arg Pro Gin Ala Asn His Glu Phe 785 790 795 800 Val Gin Pro Leu Phe Val Ser Arg Met Pro Thr Arg Lys Met Thr Gly 805 810 815 Page 2209 of 3790 Leu Asn Arg Ala 995 Thr Gly Asn Ile Asp Ile Lys Glu His Asp Leu Glu 1000 1005 Asn Ile Arg 1040 Leu Cys Lys Ser 1045 Ser Lys Arg Gin Ala 1050 Val Arg 987 1338 Page 2210 of 3790 Page 2211 of 3790 Lys Ser Lys Val Asn Gly Ile Phe Asp Asp Glu Glu Ile Leu Glu Lys 245 250 255 Ile Lys Glu Asp Asn Lys Glu Asp Phe Tyr Leu Thr Ser Glu Lys Tyr 260 265 270 Glu Glu Asn Leu Glu Tyr Phe Ser Gin Leu Leu Asp Tyr Arg Phe Glu 275 280 285 Leu Ile Ser Ser Leu Lys Ser Ile Tyr Asp Tyr Ile Ile Leu Gin Glu 290 295 300 Val Leu Lys Gly Lys Lys Tyr Leu Ser Tyr Ala Gin Val Glu Arg Tyr 305 310 315 320 Lys Asn His Lys Glu Asp Leu Arg Lys Leu Lys Gin Leu Ile Lys Lys 325 330 335 Tyr Asp Lys Asn Gly Lys Ile Tyr Tyr Gin Ile Phe Arg Asp Glu Asn 340 345 350 Phe Lys Lys Gly Tyr Val Ala Tyr Leu Gly Tyr Tyr Lys Lys Asn Lys 355 360 365 Lys Asn Val Pro Val Lys Lys Cys Asp Tyr Asp Thr Phe Ser Lys Asn 370 375 380 Ile Lys Ser Thr Leu Asp Lys Ile Cys Asp Lys Glu Asp Pro Leu Tyr 385 390 395 400 Ile Glu Leu Ile Asp Lys Ile Glu Lys Gly Gly Phe Leu Leu Lys Gin 405 410 415 Ile Val Ser Thr Asn Ser Val Ile Pro His Gin Val His Glu Leu Glu 420 425 430 Leu Asp Lys Ile Leu Glu Asn Leu Glu Lys Asn Tyr Pro Ser Phe Lys 435 440 445 Glu Ile Ser Asp Gly Val Ser Lys Ile Asp Lys Ile Lys Met Ile Phe 450 455 460 Asn Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn Asp Tyr His Lys 465 470 475 480 Asp Lys Val Asn Ser Asn Thr Trp Ile Val Lys Asn Glu Gly Phe Glu Page 2213 of 3790 Ser Lys Gin Ile Val Asp Asp Leu Tyr Val Ser Pro Ala Val Lys Lys 740 745 750 Met Ile Trp Gin Val Leu Asn Ile Asn Asp Glu Leu Ile Lys Val Leu 755 760 765 Gly Lys Gin Pro Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Lys Glu 770 775 780 Glu Lys Pro Glu Val Lys Asp Ser Arg Lys Asn Lys Leu Ile Glu Leu 785 790 795 800 Tyr Lys Asn Leu Gly Lys Glu Gly Lys Glu Trp Leu Asn Arg Ile Glu 805 810 815 Asp Lys Thr Glu Ala Asp Phe Arg Asn Arg Ala Leu Tyr Leu Tyr Tyr 820 825 830 Thr Gin Met Gly Arg Cys Met Tyr Thr Gly Glu Ile Ile Asp Ile Glu 835 840 845 Arg Leu Tyr Asp Lys Glu Leu Tyr Asp Leu Asp His Ile Ile Pro Arg 850 855 860 Lys Met Lys Lys Asp Asp Ser Ile His Lys Asn Leu Val Leu Val Thr 865 870 875 880 Arg Asn Ser Asn Gin Tyr Glu Lys Lys Asp Asn Tyr Pro Val Pro Glu 885 890 895 Val Ile Lys Ser Arg Glu Asn Val Arg His Leu Trp Tyr Ala Leu Lys 900 905 910 Lys Lys Gly Leu Ile Thr Glu Glu Lys Tyr Asn Arg Leu Thr Arg Ile 915 920 925 Asn Pro Leu Ser Asp Lys Glu Leu Ser Glu Phe Ile Glu Arg Gin Leu 930 935 940 Val Glu Thr Arg Gin Thr Thr Lys Val Val Lys Asp Leu Phe Glu Asn 945 950 955 960 Tyr Tyr Thr Asp Ser Lys Ile Val Thr Val Lys Ala Gly Leu Val Ser 965 970 975 Glu Leu Arg Arg Asp Phe Glu Val Leu Lys Cys Arg Glu Ile Asn Asp 980 985 990 Page 2214 of 3790 Leu Asn His Ala His Asp Ala Phe Leu Asn Ile Ile Val Gly Asp Val 995 1000 1005 Page 2215 of 3790 988 1023 PRT Helicobacter cinaedi 988 Page 2216 of 3790 Ser Gin Lys Leu Asp Ser Lys Asp Leu Val Arg Val Ile Leu His Ile 115 120 125 Ala Lys His Arg Gly Tyr Gly Asn Lys His Ala Lys Asp Ser Lys Asp 130 135 140 Thr Glu Ser Gly Lys Val Lys Lys Ala Ile Glu Phe Asn Arg Lys Thr 145 150 155 160 Leu Ala Glu Lys Gly Tyr Arg Ser Val Gly Glu Tyr Leu Tyr Arg Glu 165 170 175 Phe Phe Gin Gin Ser Arg Ile Ser Gin Asn Asn Gly Ala Thr Glu Phe 180 185 190 Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gin 195 200 205 Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gin Arg Gin 210 215 220 Phe Gly Phe Ser Leu Lys Gin Asp Phe Glu Asn Lys Leu Leu Thr Lys 225 230 235 240 Ile Phe Glu Gin Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 245 250 255 Cys Cys Phe Ile Ala Gly Glu Lys Arg Thr Pro Lys Asp Ser Leu Ser 260 265 270 Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 275 280 285 Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gin 290 295 300 Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 305 310 315 320 Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 325 330 335 Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 340 345 350 Glu Phe Lys Gin Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe Page 2217 of 3790 355 360 365 Thr Thr Leu Ala Arg Ser Gin Leu Asp Glu Ile Ala Glu His Ile Ala 370 375 380 Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 385 390 395 400 Leu Thr Lys Glu Gin Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 405 410 415 His Ile Asn Leu Ser Leu Gin Ala Leu Lys Gin Ile Leu Pro Phe Met 420 425 430 Arg Gly Asp Asn Gly Glu Gin Cys Leu Asp Tyr Asp Glu Ser Val Glu 435 440 445 Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gin Met 450 455 460 Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 465 470 475 480 Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Ala Leu Leu Lys 485 490 495 Gin Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 500 505 510 Lys Leu Ser Ser Thr Glu Arg Gin Lys Tyr Glu Lys Glu Gin Lys Asp 515 520 525 Asn Tyr Ala Ala Asn Gin Ala Ala His Lys Lys Cys Gin Glu Leu Gly 530 535 540 Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gin Glu 545 550 555 560 Gin Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr 565 570 575 Leu Gin Asp Pro Thr Ala Leu Gin Val Asp His Ile Tyr Pro Tyr Ser 580 585 590 Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Cys Leu Val Leu Thr Lys 595 600 605 Page 2218 of 3790 Ala Asn Gin Glu Lys Gly Asn Arg Thr Pro Phe Glu Ala Phe Gly Thr 610 615 620 Asp Ser Ala Lys Trp Gly Val Ile Thr Thr Leu Ala Gin Lys Leu Pro 625 630 635 640 His Lys Lys Arg Arg Arg Ile Leu Asn Thr Ala Phe Asn Asp Lys Glu 645 650 655 Ala Gly Phe Lys Leu Arg Asn Leu Asn Asp Thr Ser Tyr Ile Ala Arg 660 665 670 Leu Val Ala Asp Tyr Thr Glu Thr Tyr Leu Glu Phe Leu Pro Leu Val 675 680 685 Glu Ser Glu Asn Thr Thr Leu Gly Lys Gly Gin Lys Gly Ser Lys Lys 690 695 700 His Ile Ala Ile Val Asn Gly Ala Leu Thr Ser Thr Met Arg Tyr Tyr 705 710 715 720 Leu Gly Phe Ala Ser Lys Asp Arg Asp Asn His Leu His His Ala Leu 725 730 735 Asp Ala Val Ile Ile Gly Phe Met Asn Asp Ser Val Ile Lys Ala Phe 740 745 750 Ser Asp Phe Lys Lys Thr Gin Glu Thr Ser Lys Ala Ala Tyr Tyr Ala 755 760 765 His Thr Leu Ser Lys Gin Glu Tyr Lys Lys Gin Arg Ala Phe Ile Gin 770 775 780 Leu Pro Ser Gly Glu Asn Phe Arg Ala Ser Val Leu Glu Lys Val Glu 785 790 795 800 Ser Val Phe Val Ser Lys Pro Pro Arg Lys Arg Val Arg Gly Ala Leu 805 810 815 His Glu Ala Thr Phe Tyr Ser Pro Asn Asp Pro Lys Leu Leu Lys Asn 820 825 830 Tyr Gly Gly Thr Lys Gly Val Glu Arg Ala Leu Ala Leu Gly Lys Met 835 840 845 Arg Lys Val Gly Ala Lys Ile Val Ser Asn Gly Ala Met Val Arg Val 850 855 860 Page 2219 of 3790 Ser Tyr Pro Arg Glu Asn Ile Ser Leu Ala Ser Lys Ala Lys Lys 1010 1015 1020 989 1023 PRT Helicobacter cinaedi 989 Page 2220 of 3790 Asn Thr Ile Lys Gin Leu Leu Cys Lys Glu Phe Gly Leu Gin Leu Glu 65 70 75 80 Asp Tyr Leu Ser Asn Asp Gly Glu Leu Pro Lys Ala Tyr Thr Ala Ser 85 90 95 Lys Ala Asn Pro Leu Lys Ser Pro Tyr Glu Leu Arg Thr Leu Ala Leu 100 105 110 Ser Gin Lys Leu Asp Ser Lys Asp Leu Val Arg Val Ile Leu His Ile 115 120 125 Ala Lys His Arg Gly Tyr Gly Asn Lys His Ala Lys Asp Ser Lys Asp 130 135 140 Thr Glu Ser Gly Lys Val Lys Lys Ala Ile Glu Phe Asn Arg Lys Thr 145 150 155 160 Leu Ala Glu Lys Gly Tyr Arg Ser Val Gly Glu Tyr Leu Tyr Arg Glu 165 170 175 Phe Phe Gin Gin Ser Arg Ile Ser Gin Asn Asn Gly Ala Thr Glu Phe 180 185 190 Ile Asn Val Arg Asn Lys Ala Gly Asn Tyr Glu His Cys Val Ala Gin 195 200 205 Asp Met Leu Lys Glu Glu Leu Glu Ser Ile Leu Asn Ala Gin Arg Gin 210 215 220 Phe Gly Phe Ser Leu Lys Gin Asp Phe Glu Ser Lys Leu Leu Thr Lys 225 230 235 240 Ile Phe Glu Gin Arg Pro Leu Lys Ser Phe Ala Asp Lys Val Gly Asn 245 250 255 Cys Cys Phe Ile Ala Gly Glu Lys Arg Ala Pro Lys Asp Ser Pro Ser 260 265 270 Ala Ile Glu Phe Ile Ala Leu Ser Arg Thr Ile Asn Thr Leu Ile Asn 275 280 285 Leu Ser Lys Glu Ser Gly Glu Ile Tyr Asn Arg Ala Ile Ile Leu Gin 290 295 300 Ile Val Glu Ser Thr Leu Lys Lys Gly Glu Ile Ser Tyr Lys Glu Leu 305 310 315 320 Page 2221 of 3790 Arg Glu Ile Ile Arg Leu Asp Glu Arg Leu Arg Phe Lys Asp Pro Arg 325 330 335 Leu Asp Tyr Ser Arg Glu Ile Lys Glu Ala Glu Lys Val Lys Phe Leu 340 345 350 Glu Phe Lys Gin Leu Lys Gly Phe Lys Lys Ala Leu Gly Glu Ser Phe 355 360 365 Thr Thr Leu Ala Ile Ser Gin Leu Asp Glu Ile Ala Glu His Ile Ala 370 375 380 Leu Ile Lys Asp Arg Val Lys Leu Asn Glu Lys Leu Glu Ser Tyr Ala 385 390 395 400 Leu Thr Lys Glu Gin Arg Glu Ala Leu Ser Asn Leu Ser Phe Ser Ala 405 410 415 His Ile Asn Leu Ser Leu Gin Ala Leu Lys Gin Ile Leu Pro Phe Met 420 425 430 Arg Gly Asp Asn Gly Glu Gin Cys Leu Asp Tyr Asp Glu Ser Val Glu 435 440 445 Lys Ala Gly Leu Lys Ala Leu Ser Lys Asp Thr Leu Lys Gly Gin Met 450 455 460 Leu Pro Pro Leu Asn Glu Phe Glu Pro Tyr Leu Ser Asn Pro Val Val 465 470 475 480 Ala Arg Ala Leu Ala Glu Tyr Arg Lys Val Leu Asn Val Leu Leu Lys 485 490 495 Gin Tyr Gly Ser Pro His Lys Ile His Ile Glu Tyr Ala Arg Glu Ala 500 505 510 Lys Leu Ser Ser Thr Glu Arg Gin Lys Tyr Glu Lys Glu Gin Lys Asp 515 520 525 Asn Tyr Ala Ala Asn Gin Ala Ala His Lys Lys Cys Gin Glu Leu Gly 530 535 540 Leu Glu Pro Ser Ser Thr Asn Leu Leu Lys Leu Lys Leu Trp Gin Glu 545 550 555 560 Gin Gly Gly Leu Cys Leu Tyr Ser Gly Ala Lys Ile Thr Ile Ser Tyr Page 2223 of 3790 990 344 PRT Helicobacter pullorum 990 Met Lys Ile Leu Gly Phe Asp Ile Gly Ile Ala Ser Ile Gly Trp Ala 15 10 15 Page 2224 of 3790 Phe Val Glu Asn Gly Glu Leu Lys Asp Cys Gly Val Arg Ile Phe Thr 20 25 30 Lys Ala Glu Asn Pro Lys Thr Gly Asp Ser Leu Ala Met Pro Arg Arg 35 40 45 Glu Ala Arg Ser Val Arg Arg Arg Leu Ala Arg Arg Lys Gly Arg Leu 50 55 60 Glu Thr Leu Lys Arg Leu Leu Ala Lys Glu Trp Asp Leu Cys Tyr Glu 65 70 75 80 Asp Tyr Ile Ala Ala Asp Gly Glu Leu Pro Lys Ala Phe Met Gly Lys 85 90 95 Asn Leu Thr Asn Pro Tyr Val Leu Arg Tyr Glu Ala Leu Gin Arg Leu 100 105 110 Leu Ser Lys Glu Glu Leu Val Arg Val Val Leu His Ile Ala Lys His 115 120 125 Arg Gly Tyr Gly Asn Lys Asn Ala Lys Ile Thr Lys Ser Glu Glu Ser 130 135 140 Lys Arg Glu Gin Gly Lys Ile Leu Ser Ala Leu Ala Thr Asn Ala Ser 145 150 155 160 Val Ile Ala Arg Tyr Arg Thr Val Gly Glu Tyr Phe Tyr Lys Glu Phe 165 170 175 Cys Glu Val Ile Lys Asn Pro Gin Gly Leu Asn Thr Asn Glu Asn Cys 180 185 190 Thr Gin Pro Lys Val Arg Val Leu Lys Pro Ile Arg Asn Lys Gly Gly 195 200 205 Glu Tyr Thr Asn Cys Ile Leu Gin Glu Asp Leu Gin Arg Glu Leu Arg 210 215 220 Cys Ile Phe Glu His Gin Lys Gly Phe Gly Phe Ser Ile Thr Gin Glu 225 230 235 240 Phe Gin Asp Lys Ile Leu Lys Ile Ala Phe Tyr Gin Arg Ser Leu Lys 245 250 255 Asp Phe Ser His Leu Val Gly Lys Cys Thr Phe Tyr Pro Asp Glu Pro 260 265 270 Page 2225 of 3790 Page 2226 of 3790 Phe Gly Tyr Pro Glu Asn Glu Ile Glu Gin Val Ile Glu Glu Ile Asn 145 150 155 160 Phe Arg Arg Lys Thr Lys Gly Lys Asn Lys Asn Pro Met Ile Lys Leu 165 170 175 Leu Pro Glu Asp Trp Val Val Tyr Tyr Leu Arg Lys Lys Ala Leu Ile 180 185 190 Lys Pro Thr Thr Lys Glu Glu Leu Ile Arg Ile Ile Tyr Leu Phe Asn 195 200 205 Gin Arg Arg Gly Phe Lys Ser Ser Arg Lys Asp Leu Thr Glu Thr Ala 210 215 220 Ile Leu Asp Tyr Asp Glu Phe Ala Lys Arg Leu Ala Glu Lys Glu Lys 225 230 235 240 Tyr Ser Ala Glu Asn Tyr Glu Thr Lys Phe Val Ser Ile Thr Lys Val 245 250 255 Lys Glu Val Val Glu Leu Lys Thr Asp Gly Arg Lys Gly Lys Lys Arg 260 265 270 Phe Lys Val Ile Leu Glu Asp Ser Arg Ile Glu Pro Tyr Glu Ile Glu 275 280 285 Arg Lys Glu Lys Pro Asp Trp Glu Gly Lys Glu Tyr Thr Phe Leu Val 290 295 300 Thr Gin Lys Leu Glu Lys Gly Lys Phe Lys Gin Asn Lys Pro Asp Leu 305 310 315 320 Pro Lys Glu Glu Asp Trp Ala Leu Cys Thr Thr Ala Leu Asp Asn Arg 325 330 335 Met Gly Ser Lys His Pro Gly Glu Phe Phe Phe Asp Glu Leu Leu Lys 340 345 350 Ala Phe Lys Glu Lys Arg Gly Tyr Lys Ile Arg Gin Tyr Pro Val Asn 355 360 365 Arg Trp Arg Tyr Lys Lys Glu Leu Glu Phe Ile Trp Thr Lys Gin Cys 370 375 380 Gin Leu Asn Pro Glu Leu Asn Asn Leu Asn Ile Asn Lys Glu Ile Leu 385 390 395 400 Page 2227 of 3790 Arg Lys Leu Ala Thr Val Leu Tyr Pro Ser Gin Ser Lys Phe Phe Gly 405 410 415 Pro Lys Ile Lys Glu Phe Glu Asn Ser Asp Val Leu His Ile Ile Ser 420 425 430 Glu Asp Ile Ile Tyr Tyr Gin Arg Asp Leu Lys Ser Gin Lys Ser Leu 435 440 445 Ile Ser Glu Cys Arg Tyr Glu Lys Arg Lys Gly Ile Asp Gly Glu Ile 450 455 460 Tyr Gly Leu Lys Cys Ile Pro Lys Ser Ser Pro Leu Tyr Gin Glu Phe 465 470 475 480 Arg Ile Trp Gin Asp Ile His Asn Ile Lys Val Ile Arg Lys Glu Ser 485 490 495 Glu Val Asn Gly Lys Lys Lys Ile Asn Ile Asp Glu Thr Gin Leu Tyr 500 505 510 Ile Asn Glu Asn Ile Lys Glu Lys Leu Phe Glu Leu Phe Asn Ser Lys 515 520 525 Asp Ser Leu Ser Glu Lys Asp Ile Leu Glu Leu Ile Ser Leu Asn Ile 530 535 540 Ile Asn Ser Gly Ile Lys Ile Ser Lys Lys Glu Glu Glu Thr Thr His 545 550 555 560 Arg Ile Asn Leu Phe Ala Asn Arg Lys Glu Leu Lys Gly Asn Glu Thr 565 570 575 Lys Ser Arg Tyr Arg Lys Val Phe Lys Lys Leu Gly Phe Asp Gly Glu 580 585 590 Tyr Ile Leu Asn His Pro Ser Lys Leu Asn Arg Leu Trp His Ser Asp 595 600 605 Tyr Ser Asn Asp Tyr Ala Asp Lys Glu Lys Thr Glu Lys Ser Ile Leu 610 615 620 Ser Ser Leu Gly Trp Lys Asn Arg Asn Gly Lys Trp Glu Lys Ser Lys 625 630 635 640 Asn Tyr Asp Val Phe Asn Leu Pro Leu Glu Val Ala Lys Ala Ile Ala Page 2229 of 3790 Page 2230 of 3790 Page 2231 of 3790 Trp Asp Asp Asn Glu Phe Ile Ser Asn Arg Ile Tyr Gin Val Lys Page 2232 of 3790 1610 1615 1620 Leu Leu Gin Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys Ala Page 2234 of 3790 Lys Val Val Pro Lys Ser His Pro Ile Phe Gin Glu Phe Arg Ile Trp 385 390 395 400 Gin Asn Leu Asn Asn Leu Thr Leu Ile Lys Lys Asp Asn Leu Asn Glu 405 410 415 Lys Cys Glu Leu Ala Leu Glu Asp Lys Thr Ala Leu Ala Asn Glu Leu 420 425 430 Ala Phe Lys Lys Glu Leu Ser Val Lys Asp Ala Leu Lys Val Leu Gly 435 440 445 Leu Lys Pro Ser Asp Trp Glu Phe Asn Phe Thr Lys Ile Glu Gly Asn 450 455 460 Arg Thr Asn His Ala Phe Phe Glu Ala Phe Ala Lys Ile Ile Glu Leu 465 470 475 480 Glu Asp Gly Glu Pro Ile Asp Leu Gly Asn Leu Lys Ala Asp Asp Ile 485 490 495 Leu Asp Gin Phe Ser Glu Ala Phe Leu Arg Ile Gly Ile Asp Thr Glu 500 505 510 Leu Leu Gin Val Asn Ser Asp Ile Glu Gly Ala Glu Tyr Glu Lys Gin 515 520 525 Ser Tyr Ile Gin Phe Trp His Leu Leu Tyr Ser Ser Glu Asp Asp Gin 530 535 540 Lys Leu Lys Gin Asn Leu Ile Arg Lys Phe Gly Phe Lys Pro Glu His 545 550 555 560 Ala Lys Ile Leu Ala Ser Ile Ser Leu Gin Asp Asp His Ala Ser Leu 565 570 575 Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gin Ser Gly Leu 580 585 590 Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 595 600 605 Phe Thr Lys Asp Glu Asn Glu Lys Arg Glu Leu Arg Ala Glu Leu Glu 610 615 620 Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 625 630 635 640 Page 2235 of 3790 Asn Gin Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Asn Leu 645 650 655 Gly Arg Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 660 665 670 Asn Ala Glu Gin Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 675 680 685 Arg Asp His Glu Lys Tyr Arg Glu Ile Leu Lys Lys Glu Phe Gly Leu 690 695 700 Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 705 710 715 720 Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 725 730 735 Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Ala Arg 740 745 750 Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gin Leu 755 760 765 Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gin Asn Lys 770 775 780 Leu Ser Ala Asp Glu Phe Glu Gin Tyr Gin Ser Arg Val Lys Ser Leu 785 790 795 800 Tyr Gly Lys Leu Ser Lys Ala Lys Ile Gin Lys Leu Leu Met Ala Asn 805 810 815 Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gin Leu Gin Glu Thr Arg 820 825 830 Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Thr Met Arg 835 840 845 Val Ser Val Thr Thr Gly Thr Ile Thr Asp Lys Leu Arg Glu Asp Trp 850 855 860 Gly Leu Val Glu Ile Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys 865 870 875 880 Leu Gly Leu Thr Tyr Thr Ile Glu Gly Lys His Gly Glu Arg Leu Asn 885 890 895 Page 2236 of 3790 Glu Ser Arg Leu Glu Glu Phe Gly Gly Asn Ala Lys Leu Ala Phe Tyr Page 2238 of 3790 Arg Ser Asp Leu Gin Glu Glu Phe Lys Asn Ile Trp Asn Asn Gin Lys 195 200 205 Thr Tyr Tyr Phe Asp Ile Leu Thr Asp Thr Leu Phe Glu Glu Leu Lys 210 215 220 Page 2239 of 3790 Asp Lys Asn Lys Ser Gin Thr Trp Ala Ile Cys Lys Lys Pro Phe Asp 225 230 235 240 Ile Ala Gly Ile Lys Gin Ile Gly Lys Ala Ser Asp Lys Arg Leu Glu 245 250 255 Arg Tyr Lys Trp Arg Thr Glu Gly Leu Thr Gin Lys Leu Asn Leu Glu 260 265 270 Tyr Leu Ala Ile Ala Leu Gin Glu Ile Asn Asn Asp Ile Asn Lys Ser 275 280 285 Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe 290 295 300 Asn Lys Glu Thr Val Gly Glu Asn Leu Tyr Arg Gin Leu Val Lys Thr 305 310 315 320 Pro His Thr Ser Leu Arg Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu 325 330 335 Asp Glu Phe Glu Thr Ile Trp Glu Thr Gin Ala Lys Phe Tyr Pro Gin 340 345 350 Leu Thr His Thr Leu Lys Glu Glu Ile Arg Asp Val Ile Ile Phe Tyr 355 360 365 Gin Arg Lys Leu Lys Ser Gin Lys Ser Leu Ile Ser Phe Cys Gin Phe 370 375 380 Glu Ser Trp Glu Gin Thr Tyr Ile Glu Lys Glu Thr Gly Lys Ser Lys 385 390 395 400 Thr Arg Thr Val Gly Arg Lys Val Ile Pro Lys Ser Ser Pro Leu Phe 405 410 415 Gin Glu Phe Lys Ile Trp Gin Asn Leu Asn Ser Leu Glu Phe Arg Asn 420 425 430 Ser Asp Glu Gly Glu Ile Ile Glu Phe Ile Lys Leu Asp Glu Asp Ile 435 440 445 Arg Gin Thr Val Phe Glu Glu Leu Asn Leu Arg Gly Asn Leu Lys Pro 450 455 460 Asn Asp Val Leu Lys Ile Leu Gly Asn Tyr Ile Ser Leu Gly Lys Val 465 470 475 480 Page 2240 of 3790 Ser Gin Trp Lys Cys Asn Phe Glu Glu Ile Glu Gly Asn Arg Thr Asn 485 490 495 Ala Ala Leu Tyr Asn Val Tyr Gin Ile Ile Ala Glu Asn Glu Gly Tyr 500 505 510 Gly Phe Asp Trp Ala Lys Lys Thr Ala Ser Glu Ile Asn Lys Glu Leu 515 520 525 Lys Asn Ile Phe Pro Gin Leu Gly Ile Asp Ala Ser Ile Leu Asp Phe 530 535 540 Asp Phe Thr Gin Ala Asn Phe Asp Lys Gin Thr Ser Tyr Gin Leu Trp 545 550 555 560 His Leu Leu Tyr Ser Ala Glu Glu Asp Phe Lys Ile Ser Glu Glu Asp 565 570 575 Lys Val Leu Tyr Gly Asn Ser Ser Val Ser Leu Lys Lys Lys Leu His 580 585 590 Gin Lys Tyr Gly Phe Lys Pro Glu Tyr Thr Lys Leu Leu Thr Asn Ile 595 600 605 Ser Leu Gin Pro Asp Tyr Gly Asn Leu Ser Ala Lys Ala Ile Cys Asn 610 615 620 Ile Leu Pro Tyr Leu Lys Glu Asn Asn Val Tyr Ser Glu Ala Cys Asp 625 630 635 640 Leu Thr Gly Tyr Asn His Ser Asn Phe Leu Thr Ala Glu Glu Gin Ala 645 650 655 Lys Arg Pro Leu Lys Pro Ile Leu Glu Leu Leu Lys Lys Asn Ser Leu 660 665 670 Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gin Met Val Asn Val Val 675 680 685 Asn Gin Val Ile Glu Thr Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu 690 695 700 Leu Thr Arg Glu Leu Lys Lys Ser Ala Lys Glu Arg Ala Asn Met Thr 705 710 715 720 Lys Ser Ile Ala Asp Ala Thr Arg Arg Asn Asp Asp Tyr Arg Lys Thr 725 730 735 Page 2241 of 3790 Ile Ile Lys Glu Phe Gly Ile Pro Asn Pro Thr Lys Ser Asp Val Val 740 745 750 Arg Tyr Arg Leu Trp Gin Glu Leu Ala Ser Arg Gly Tyr Lys Asp Ile 755 760 765 Phe Thr Asp Thr Glu Ile Lys Pro Gin Glu Leu Phe Ser Asn Lys Ile 770 775 780 Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu Phe Asp Asp Ser Phe 785 790 795 800 Ser Asn Lys Thr Leu Ala Phe Lys Lys Asp Asn Leu Lys Lys Ala Asn 805 810 815 Arg Thr Ala Tyr Asp Phe Ile Ala Asn Asp Tyr Ala Pro Asn Leu Glu 820 825 830 Asn Tyr Ile Glu Arg Val Glu Ser Leu His Lys Asp Arg Lys Ile Thr 835 840 845 Arg Ala Lys Arg Asn Lys Leu Leu Met Leu Gin Ser Lys Leu Pro Asp 850 855 860 Gly Phe Ile Glu Arg Asp Leu Arg Asn Ser Gin Tyr Ile Thr Lys Glu 865 870 875 880 Ala Lys Lys Met Leu Tyr Glu Val Cys Arg Thr Val Val Ser Thr Ser 885 890 895 Gly Ser Ile Thr Asp Lys Leu Arg Glu Asp Trp Asp Leu Ile Asn Val 900 905 910 Met Lys Glu Leu Asn Phe Pro Lys Tyr Lys Ala Leu Gly Leu Thr Glu 915 920 925 Lys Ile Glu Arg Tyr Asp Ile Gly Ala Glu Lys Met Lys Glu Val Glu 930 935 940 Ile Ile Glu Asp Trp Asn Lys Arg Asn Asp His Arg His His Ala Ile 945 950 955 960 Asp Ala Leu Thr Val Ala Phe Ser Thr His Ser His Ile Gin Tyr Leu 965 970 975 Asn His Leu Asn Ala Arg Arg Asp Glu Gly His Lys Lys His Ala Ala 980 990 Page 2242 of 3790 985 Ile Ile Ala Ile Glu Ser Thr Ile Thr Glu Lys Glu Gly Asn Lys Lys 995 1000 1005 Page 2243 of 3790 994 1060 PRT Kingella kingae 994 Met Ala Ala Lys Ser Leu Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ile 15 10 15 Ala Ser Cys Gly Trp Ala Val Val Glu Met Asp Glu Gin Glu Asn Pro 20 25 30 Page 2244 of 3790 Leu Arg Leu Ile Asp Val Gly Val Arg Thr Phe Glu Glu Ala Glu Asn 35 40 45 Pro Lys Asp Gly Ser Ser Leu Ala Glu Thr Arg Arg Leu Ala Arg Ala 50 55 60 Gin Arg Arg Leu Ile Ser Arg Arg Ala Asn Arg Met Asn Lys Leu Cys 65 70 75 80 Arg Leu Leu Lys Gin Glu Asn Val Leu Gin Ala Asn Asp Tyr Asp Glu 85 90 95 Lys Gly Leu Ile Ile Gly Leu Pro Asn Gin Ala Trp Glu Leu Arg Ala 100 105 110 Gin Gly Leu Asp Arg Lys Leu Glu Pro Lys Glu Trp Ala Ala Val Leu 115 120 125 Ile His Leu Val Lys His Arg Gly Tyr Leu Ser Gin Arg Lys Asn Glu 130 135 140 Ser Gin Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Ser Gly Met Asn 145 150 155 160 His Asn His Gin Leu Leu Gin Ser Gin Ser Asn Gin Tyr Arg Thr Pro 165 170 175 Ala Glu Leu Ala Ile Lys Gin Phe Ala Thr Gin Asp Gly His Ile Arg 180 185 190 Asn Gin Arg Gly Ala Tyr Thr His Thr Phe Asn Arg Leu Asp Leu Gin 195 200 205 Asn Glu Leu Asn Gin Leu Phe Asp Ala Gin Thr Arg Leu Gly Asn Pro 210 215 220 His Val Ser Gly Ser Leu Lys Thr Ala Ile Asn Asp Leu Leu Met Asn 225 230 235 240 Gin Lys Ala Ala Leu Ser Gly Asp Ala Ile Leu Glu Met Leu Gly Arg 245 250 255 Cys Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr Ser 260 265 270 Ala Glu Arg Phe Val Trp Leu Gly Lys Leu Thr Asn Leu Arg Ile Gin 275 280 285 Page 2245 of 3790 Asp Asn Gly Leu Glu Ser Ala Leu Ser Arg Glu Gin Arg Glu Leu Leu 290 295 300 Leu Asn Glu Pro Tyr Asn Lys Thr Lys Leu Thr Tyr Gin Gin Val Arg 305 310 315 320 Lys Leu Leu Arg Leu Pro Glu Thr Ala Phe Phe Lys Gly Leu Arg Tyr 325 330 335 Gly Lys Asp Asn Ala Glu Ser Ala Thr Phe Met Glu Met Lys Ser Tyr 340 345 350 His Ala Ile Arg Lys Ser Leu Glu Asn Lys Ser Leu Lys Ser Glu Trp 355 360 365 Glu Lys Leu Lys Thr Gin Pro Lys Leu Leu Asp Leu Ile Gly Thr Ala 370 375 380 Phe Ser Ile Tyr Lys Thr Asp Asp Glu Ile Ala Gly Cys Leu Lys Asn 385 390 395 400 Gin Leu Pro Glu Asn Val Ile Ile Ala Leu Gin Gly Gin Leu Asn Phe 405 410 415 Ser Asn Phe Met Glu Leu Ser Leu Lys Ala Leu Glu Lys Leu Leu Pro 420 425 430 Leu Met Glu Gin Gly Leu Arg Tyr Asp Glu Ala Cys Thr Gin Ile Tyr 435 440 445 Gly Asn Arg His Glu Lys Ile Ala Asp Lys Thr Glu Lys Phe Leu Pro 450 455 460 Asn Ile Pro Ala Asp Lys Leu Arg Asn Pro Val Val Leu Arg Thr Leu 465 470 475 480 Thr Gin Ala Arg Lys Val Ile Asn Ala Ile Ile Arg Arg Tyr Gly Ser 485 490 495 Pro Ala Arg Val His Ile Glu Thr Gly Arg Glu Val Gly Lys Ser Phe 500 505 510 Ser Asp Arg Asp Lys Leu Lys Lys Gin Gin Glu Glu Asn Gin Glu Gin 515 520 525 Arg Arg Arg Ala Ile Asp Glu Trp Lys Gin Phe Phe Pro Asn Ala Ala 530 535 540 Page 2246 of 3790 His Glu Pro Lys Ala Val Asp Ile Leu Lys Leu Arg Leu Tyr Gin Leu 545 550 555 560 Gin Gin Gly Lys Cys Leu Tyr Ser Gly Leu Pro Ile Asp Val Arg Arg 565 570 575 Leu Pro Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe Ser 580 585 590 Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Ile Leu Val Leu Ala Ser 595 600 605 Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Leu Arg Gly 610 615 620 Ala Asp Asn Ser Glu Ser Trp Arg Leu Phe Val Glu Asn Val Gin Asn 625 630 635 640 Cys Gin Phe Ser Pro Asn Lys Lys Gin Lys Ile Met Ala Lys Gin Leu 645 650 655 Asp Glu Lys Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Val 660 665 670 Ser Arg Phe Leu Cys Gin Phe Ile Ser Glu His Leu His Leu Thr Gly 675 680 685 Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Ala Leu 690 695 700 Leu Arg Gly Arg Trp Gly Leu Ser Lys Asn Arg Glu Glu Asn Asp Arg 705 710 715 720 His His Ala Val Asp Ala Val Val Val Ala Cys Ser Thr Val Ala Met 725 730 735 Gin Gin Lys Ile Thr Gin Phe Val Arg Tyr Gin Lys Gly Asn Val Phe 740 745 750 Thr Gly Glu Arg Ile Asp Lys Glu Thr Gly Glu Val Ile Ser Ile His 755 760 765 Phe Pro Thr Pro Trp Glu His Phe Arg Glu Glu Val Met Ile Arg Val 770 775 780 Phe Asp Asp Asn Pro Leu Arg Thr Leu Pro Glu Lys Leu Pro Asn Arg Gly Ile Met Gly Tyr Phe Ala Ser Leu Asp Arg Ala Thr Gly Ala Ile 995 1000 1005 Thr Ile Arg Glu His Asp Arg Asp Lys Lys Lys Cys Lys Asp Gly 1010 1015 1020 Glu His Arg Ser Ile Gly Val Lys Met Ala Ser Ser Phe Lys Lys 1025 1030 1035 Page 2248 of 3790 Leu Gin Val Asp Glu Leu Gly Lys Asn Ile His Glu Thr Arg Ser Page 2249 of 3790 Leu Asn Glu Asn Ser Asp Glu Asn Leu Gly Lys Leu Asp Val Ala Asp 195 200 205 Ile Phe Lys Asn Asn Thr Phe Ser Lys Thr Lys Lys Ser Glu Glu Leu 210 215 220 Leu Lys Leu Ser Gly Ala Lys Lys Asn Gin Leu Ala His Gin Leu Phe 225 230 235 240 Lys Met Met Val Gly Asn Met Gly Ser Phe Lys Lys Val Leu Gly Thr 245 250 255 Asp Glu Glu His Lys Leu Ser Phe Gly Lys Asp Thr Tyr Glu Asp Asp 260 265 270 Leu Asn Asp Leu Leu Ala Glu Ala Gly Asp Gin Tyr Leu Asp Ile Phe 275 280 285 Val Ala Ala Lys Lys Val Tyr Asp Ala Ala Ile Leu Ala Ser Ile Leu 290 295 300 Asp Val Lys Asp Thr Gin Thr Lys Thr Val Phe Ser Gin Ala Met Ile 305 310 315 320 Glu Arg Tyr Glu Glu His Gin Lys Asp Leu Ile Glu Leu Lys Arg Val 325 330 335 Phe Lys Lys Tyr Leu Pro Glu Lys Cys His Asp Phe Phe Ser Glu Pro 340 345 350 Lys Ile Ser Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Val Ser Glu Glu 355 360 365 Asp Phe Tyr Lys Tyr Thr Lys Lys Thr Leu Lys Gly Ile Pro Glu Thr 370 375 380 Glu Glu Ile Leu Gin Lys Ile Asp Ala Asn Asn Tyr Leu Arg Lys Gin 385 390 395 400 Arg Thr Phe Asp Asn Gly Ala Ile Pro His Gin Val His Leu Lys Glu 405 410 415 Leu Val Ala Ile Val Glu Asn Gin Gly Lys Tyr Tyr Pro Phe Leu Arg 420 425 430 Glu Asn Lys Asp Lys Phe Glu Lys Ile Leu Asn Phe Arg Ile Pro Tyr 435 440 445 Page 2250 of 3790 Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Lys Phe Ala Trp Leu Thr 450 455 460 Arg Ala Gly Glu Gly Lys Ile Thr Pro Tyr Asn Phe Asp Glu Met Ile 465 470 475 480 Asp Lys Glu Thr Ser Ala Glu Asp Phe Ile Lys His Met Thr Ile Asn 485 490 495 Asp Leu Tyr Leu Pro Thr Glu Pro Val Leu Pro Lys His Ser Leu Leu 500 505 510 Tyr Glu Arg Tyr Thr Ile Phe Asn Glu Leu Ala Gly Val Arg Tyr Val 515 520 525 Thr Glu Asn Gly Glu Ala Lys Tyr Phe Asp Ala Gin Thr Lys Arg Ser 530 535 540 Ile Phe Glu Leu Phe Lys Leu Asp Arg Lys Val Ser Glu Lys Met Val 545 550 555 560 Ile Lys His Leu Lys Val Val Met Pro Ala Ile Arg Ile Gin Ala Leu 565 570 575 Lys Gly Leu Asp Asn Gly Lys Phe Asn Ala Ser Tyr Gly Thr Tyr Lys 580 585 590 Asp Leu Val Asp Met Gly Val Ala Pro Glu Leu Leu Asn Asp Glu Val 595 600 605 Asn Ser Glu Lys Trp Glu Asp Ile Ile Lys Thr Leu Thr Ile Phe Glu 610 615 620 Gly Arg Lys Leu Ile Lys Arg Arg Leu Glu Asn Tyr Arg Asp Phe Leu 625 630 635 640 Gly Glu Asp Ile Leu Arg Lys Leu Ser Arg Lys Lys Tyr Thr Gly Trp 645 650 655 Gly Arg Leu Ser Ala Lys Leu Leu Asp Gly Ile Tyr Asp Lys Lys Thr 660 665 670 His Lys Thr Ile Leu Asp Cys Leu Met Thr Glu Asp Tyr Ser Gin Asn 675 680 685 Phe Met Gin Leu Ile Asn Asp Asp Asn Tyr Ser Phe Lys Glu Thr Ile 690 695 700 Page 2251 of 3790 Lys Asn Ala Gin Val Ile Glu Lys Glu Glu Thr Leu Ala Lys Thr Val 705 710 715 720 Gin Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser 725 730 735 Leu Glu Ile Val Asp Glu Ile Ile Lys Val Met Gly Tyr Lys Pro Lys 740 745 750 Ser Ile Val Val Glu Met Ala Arg Glu Thr Gin Lys Thr His Gly Thr 755 760 765 Arg Lys Arg Glu Asp Arg Val Gin Gin Ile Val Glu Asn Leu Lys Asp 770 775 780 Ala Asn Glu Leu Pro Glu Lys Leu Pro Ser Asn Ala Glu Leu Ser Asp 785 790 795 800 Glu Arg Lys Tyr Leu Tyr Cys Leu Gin Asn Gly Arg Asp Met Tyr Thr 805 810 815 Gly Ala Pro Leu Asp Tyr Asp His Leu Gin Phe Tyr Asp Val Asp His 820 825 830 Ile Ile Pro Gin Ser Phe Leu Lys Asp Asp Ser Ile Glu Asn Lys Val 835 840 845 Leu Thr Ile Lys Lys Glu Asn Val Arg Lys Thr Asn Gly Leu Pro Ser 850 855 860 Glu Ala Val Ile Gin Lys Met Gly Ser Phe Trp Lys Lys Leu Leu Asp 865 870 875 880 Ala Gly Ala Met Thr Asn Lys Lys Tyr Asp Asn Leu Arg Arg Asn Leu 885 890 895 His Gly Gly Leu Asn Glu Lys Leu Lys Glu Arg Phe Ile Glu Arg Gin 900 905 910 Leu Val Glu Thr Arg Gin Ile Thr Lys Tyr Val Ala Gin Leu Leu Asp 915 920 925 Gin Arg Leu Asn Tyr Asp Gly Asn Gly Val Glu Leu Asp Glu Lys Ile 930 935 940 Ala Ile Val Thr Leu Lys Ala Gin Leu Ala Ser Gin Phe Arg Ser Glu 960 945 950 Page 2252 of 3790 955 1310 996 1371 PRT Lactobacillus buchneri 996 Met Lys Val Asn Asn Tyr His Ile Gly Leu Asp Ile Gly Thr Ser Ser 15 10 15 Ile Gly Trp Val Ala Ile Gly Lys Asp Gly Lys Pro Leu Arg Val Lys 20 25 30 Gly Lys Thr Ala Ile Gly Ala Arg Leu Phe Gin Glu Gly Asn Pro Ala 35 40 45 Ala Asp Arg Arg Met Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 50 55 60 Lys Trp Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Ile Thr 65 70 75 80 Page 2254 of 3790 Pro Val Asp Ser Thr Phe Phe Ala Arg Leu Lys Gin Ser Asn Leu Ser 85 90 95 Pro Lys Asp Ser Arg Lys Glu Phe Lys Gly Ser Met Leu Phe Pro Asp 100 105 110 Leu Thr Asp Met Gin Tyr His Lys Asn Tyr Pro Thr Ile Tyr His Leu 115 120 125 Arg His Ala Leu Met Thr Gin Asp Lys Lys Phe Asp Ile Arg Met Val 130 135 140 Tyr Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Asn 145 150 155 160 Ser Thr Pro Val Asp Ser Phe Lys Ala Ser Lys Val Asp Phe Val Asp 165 170 175 Gin Phe Lys Lys Leu Asn Glu Leu Tyr Ala Ala Ile Asn Pro Glu Glu 180 185 190 Ser Phe Lys Ile Asn Leu Ala Asn Ser Glu Asp Ile Gly His Gin Phe 195 200 205 Leu Asp Pro Ser Ile Arg Lys Phe Asp Lys Lys Lys Gin Ile Pro Lys 210 215 220 Ile Val Pro Val Met Met Asn Asp Lys Val Thr Asp Arg Leu Asn Gly 225 230 235 240 Lys Ile Ala Ser Glu Ile Ile His Ala Ile Leu Gly Tyr Lys Ala Lys 245 250 255 Leu Asp Val Val Leu Gin Cys Thr Pro Val Asp Ser Lys Pro Trp Ala 260 265 270 Leu Lys Phe Asp Asp Glu Asp Ile Asp Ala Lys Leu Glu Lys Ile Leu 275 280 285 Pro Glu Met Asp Glu Asn Gin Gin Ser Ile Val Ala Ile Leu Gin Asn 290 295 300 Leu Tyr Ser Gin Val Thr Leu Asn Gin Ile Val Pro Asn Gly Met Ser 305 310 315 320 Leu Ser Glu Ser Met Ile Glu Lys Tyr Asn Asp His His Asp His Leu 325 330 335 Page 2255 of 3790 Lys Leu Tyr Lys Lys Leu Ile Asp Gin Leu Ala Asp Pro Lys Lys Lys 340 345 350 Ala Val Leu Lys Lys Ala Tyr Ser Gin Tyr Val Gly Asp Asp Gly Lys 355 360 365 Val Ile Glu Gin Ala Glu Phe Trp Ser Ser Val Lys Lys Asn Leu Asp 370 375 380 Asp Ser Glu Leu Ser Lys Gin Ile Met Asp Leu Ile Asp Ala Glu Lys 385 390 395 400 Phe Met Pro Lys Gin Arg Thr Ser Gin Asn Gly Val Ile Pro His Gin 405 410 415 Leu His Gin Arg Glu Leu Asp Glu Ile Ile Glu His Gin Ser Lys Tyr 420 425 430 Tyr Pro Trp Leu Val Glu Ile Asn Pro Asn Lys His Asp Leu His Leu 435 440 445 Ala Lys Tyr Lys Ile Glu Gin Leu Val Ala Phe Arg Val Pro Tyr Tyr 450 455 460 Val Gly Pro Met Ile Thr Pro Lys Asp Gin Ala Glu Ser Ala Glu Thr 465 470 475 480 Val Phe Ser Trp Met Glu Arg Lys Gly Thr Glu Thr Gly Gin Ile Thr 485 490 495 Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Lys Ala Ser Ala Asn Arg 500 505 510 Phe Ile Lys Arg Met Thr Thr Lys Asp Thr Tyr Leu Ile Gly Glu Asp 515 520 525 Val Leu Pro Asp Glu Ser Leu Leu Tyr Glu Lys Phe Lys Val Leu Asn 530 535 540 Glu Leu Asn Met Val Arg Val Asn Gly Lys Leu Leu Lys Val Ala Asp 545 550 555 560 Lys Gin Ala Ile Phe Gin Asp Leu Phe Glu Asn Tyr Lys His Val Ser 565 570 575 Val Lys Lys Leu Gin Asn Tyr Ile Lys Ala Lys Thr Gly Leu Pro Ser 580 585 590 Page 2256 of 3790 Asp Pro Glu Ile Ser Gly Leu Ser Asp Pro Glu His Phe Asn Asn Ser 595 600 605 Leu Gly Thr Tyr Asn Asp Phe Lys Lys Leu Phe Gly Ser Lys Val Asp 610 615 620 Glu Pro Asp Leu Gin Asp Asp Phe Glu Lys Ile Val Glu Trp Ser Thr 625 630 635 640 Val Phe Glu Asp Lys Lys Ile Leu Arg Glu Lys Leu Asn Glu Ile Thr 645 650 655 Trp Leu Ser Asp Gin Gin Lys Asp Val Leu Glu Ser Ser Arg Tyr Gin 660 665 670 Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asn Asp 675 680 685 Gin Gly Glu Arg Ile Ile Asp Lys Leu Trp Asn Thr Asn Lys Asn Phe 690 695 700 Met Gin Ile Gin Ser Asp Asp Asp Phe Ala Lys Arg Ile His Glu Ala 705 710 715 720 Asn Ala Asp Gin Met Gin Ala Val Asp Val Glu Asp Val Leu Ala Asp 725 730 735 Ala Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg Gin Val Val Lys 740 745 750 Val Val Asp Asp Ile Gin Lys Ala Met Gly Gly Val Ala Pro Lys Tyr 755 760 765 Ile Ser Ile Glu Phe Thr Arg Ser Glu Asp Arg Asn Pro Arg Arg Thr 770 775 780 Ile Ser Arg Gin Arg Gin Leu Glu Asn Thr Leu Lys Asp Thr Ala Lys 785 790 795 800 Ser Leu Ala Lys Ser Ile Asn Pro Glu Leu Leu Ser Glu Leu Asp Asn 805 810 815 Ala Ala Lys Ser Lys Lys Gly Leu Thr Asp Arg Leu Tyr Leu Tyr Phe 820 825 830 Thr Gin Leu Gly Lys Asp Ile Tyr Thr Gly Glu Pro Ile Asn Ile Asp Page 2257 of 3790 Page 2258 of 3790 Page 2259 of 3790 Lys Asp Leu 1370 997 315 PRT Lactobacillus casei 997 Page 2260 of 3790 Page 2261 of 3790 Page 2262 of 3790 Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg Leu Lys Gly Lys 50 55 60 Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys Ala Ala Ala Asp 65 70 75 80 Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser Arg Asn Arg Trp 85 90 95 Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His Ile Thr Pro Thr 100 105 110 Gly Pro Asn Phe Phe Met Arg Gin Lys Tyr Ser Glu Ile Ser Pro Lys 115 120 125 Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe Asn Asp Arg Thr 130 135 140 Asp Ala Glu Phe Tyr Gin Gin Tyr Pro Thr Met Tyr His Leu Arg Asn 145 150 155 160 Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg Glu Ile Tyr Phe 165 170 175 Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe Leu Thr Ser Gly 180 185 190 Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu Asn Glu Ile Phe 195 200 205 Pro Ala Leu Gin Asp Ala Tyr Ala Gin Val Tyr Pro Asp Leu Asp Ile 210 215 220 Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr Val Leu Leu Asn 225 230 235 240 Glu Lys Ala Thr Pro Ser Asp Thr Gin Arg Ala Leu Val Asn Leu Leu 245 250 255 Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gin Gin Lys Gin Val 260 265 270 Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys Thr Lys Leu Asn 275 280 285 Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala Thr Val Trp Asn 290 295 300 Page 2263 of 3790 Phe Ser Leu Gly Gin Leu Asp Asp Lys Trp Ala Gly Ile Glu Ser Ala 305 310 315 320 Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gin Ile Arg Asp Leu Tyr 325 330 335 Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly Lys Thr Leu Ser 340 345 350 Gin Ala Lys Val Asp Asp Tyr Ala Gin His His Glu Asp Leu Glu Leu 355 360 365 Phe Lys Asp Tyr Leu Lys Gin Leu Glu Asp Asp Gly Thr Ala Lys Ala 370 375 380 Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp Asp Ala Lys Pro 385 390 395 400 Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys Glu Val Thr Ala 405 410 415 His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg Leu Ala Gin Pro 420 425 430 Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly Ala Ile Pro Val 435 440 445 Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys Asn Gin Ser Val 450 455 460 Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu Lys His Arg Lys 465 470 475 480 Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe Arg Ile Pro Tyr 485 490 495 Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys Ala Ala Gin Gly 500 505 510 Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp Gly Asn Ile Thr 515 520 525 Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala Ser Ala Asn Thr 530 535 540 Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu Ile Gly Glu Asp Page 2265 of 3790 Page 2266 of 3790 Page 2267 of 3790 1385 1000 412 PRT Lactobacillus casei Page 2268 of 3790 Asp Phe Pro Lys Asn Arg Glu Val Asn His Tyr His His Ala Phe Asp 115 120 125 Ala Phe Leu Ala Ala Arg Ile Gly Thr Tyr Leu Leu Lys Arg Tyr Pro 130 135 140 Asn Leu Glu Pro Phe Phe Thr Tyr Gly Lys Phe Lys Lys Thr Glu Val 145 150 155 160 Lys Lys Leu Lys Ser Phe Asn Phe Ile Arg Asp Met Thr His Ala Lys 165 170 175 Asp Lys Ile Val Ala Lys Glu Thr Gly Glu Ile Val Trp Asp Asn Ala 180 185 190 Ser Asp Ile Asn Glu Leu Asp Arg Ile Tyr Asn Phe Lys Arg Met Leu 195 200 205 Ile Thr His Glu Val Arg Phe Glu Thr Ala Ser Leu Phe Lys Gin Thr 210 215 220 Leu Tyr Ala Ala Lys Asn Pro Lys Asn Arg Gly Gly Ser Arg Gin Leu 225 230 235 240 Ile Pro Lys Lys Lys Gly Tyr Leu Val Asp Ile Tyr Gly Gly Tyr Thr 245 250 255 Gin Glu Thr Gly Ser Tyr Leu Ser Val Val Arg Leu Thr Lys Lys Ala 260 265 270 Met Tyr Ala Val Val Lys Val Ser Thr Arg Asp Ala Ala Lys Leu Ala 275 280 285 Val Ala Lys Ser Ile Ser Glu Gin Lys Glu Asn Glu Thr Leu Lys Lys 290 295 300 Ile Ile Asp Gly Lys Leu Ser Lys Thr Ser Lys Lys Gly Lys Thr Thr 305 310 315 320 His Gin Leu Phe Glu Ile Val Leu Pro Arg Val Gly Gin Lys Thr Leu 325 330 335 Phe Lys Asn Ser Lys Tyr Asn Gin Phe Leu Val Asn Ser Asp Thr Tyr 340 345 350 Met His Asn Tyr Gin Glu Leu Trp Met Pro Arg Glu Tyr Gin Arg Met Page 2269 of 3790 Ala Val Asp Asp Thr Asp Gin Ser Val Gly Lys Ile Thr Val Ile Asn 165 175 Page 2270 of 3790 170 Tyr Asp Ile Asp His Ile Leu Pro Gin Ser Leu Ile Lys Asp Asn Ser Page 2272 of 3790 Page 2273 of 3790 Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 50 55 60 Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 65 70 75 80 Ile Thr Pro Thr Asp Pro Asn Phe Phe Met Arg Gin Lys Tyr Ser Glu 85 90 95 Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 100 105 110 Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gin Gin Tyr Pro Thr Met Tyr 115 120 125 His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 130 135 140 Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 145 150 155 160 Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 165 170 175 Asn Glu Ile Phe Pro Ala Leu Gin Asp Ala Tyr Ala Gin Val Tyr Pro 180 185 190 Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 195 200 205 Val Leu Leu Asp Glu Lys Ala Thr Pro Ser Asp Thr Gin Arg Ala Leu 210 215 220 Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gin 225 230 235 240 Gin Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 245 250 255 Met Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 260 265 270 Thr Ala Trp Asn Phe Ser Leu Gly Gin Leu Asp Asp Lys Trp Ala Gly 275 280 285 Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gin Ile 290 295 300 Page 2274 of 3790 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Lys Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Glu Gin His His Glu 325 330 335 Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Met Ala Lys Val Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Leu Val Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Gin Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Ser Tyr 530 535 540 Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 545 550 555 560 Page 2275 of 3790 Ser Phe Asp Gin Lys Gin Gin Val Leu Gly Glu Leu Phe Glu Arg His 565 570 575 Asn Thr Val Thr Ile Lys Gin Phe Val Asp Asn Leu Leu Ala His Gly 580 585 590 Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gin Leu Lys Gly Ile Leu His 610 615 620 Glu Ala Ile Asp Asp Ser Asp Lys Gin Thr Asp Ile Glu Lys Ile Ile 625 630 635 640 Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu 645 650 655 Asn Glu Ile Ser Trp Leu Thr Ala Gly Met Ile Asn Ser Leu Ala Asn 660 665 670 Ile Arg Tyr Arg Gly Trp Gly Gin Phe Ser His Lys Leu Leu Asn Glu 675 680 685 Leu Thr Leu Ser Thr Gly Arg Thr Val Phe Glu Glu Leu Leu Ile Ser 690 695 700 Ser His Asn Leu Met Gin Ile Leu Thr Asp Glu Val Leu Lys Gin Lys 705 710 715 720 Ile Ala Glu Leu Asn Ala His Glu Leu Lys Ala Ser Gly Ile Tyr Ala 725 730 735 Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 740 745 750 Gin Val Leu Ser Val Ile Asp Asp Ile Thr Asn Ala Ala Gly Gin Ala 755 760 765 Pro Asn Trp Leu Tyr Ile Glu Thr Ala Asp Gly Asp Gly Val Pro Gly 770 775 780 Lys Arg Thr Asn Ser Arg Gin Arg Lys Ile Gin Glu Ile Tyr Ala Asn 785 790 795 800 Ala Ala Gin Glu Leu Ile Thr Gly Ser Val Arg Gly Glu Leu Glu Asp 805 815 Page 2276 of 3790 810 Page 2278 of 3790 1004 1360 PRT Lactobacilius casei 1004 Page 2279 of 3790 Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 145 150 155 160 Leu Thr Pro Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 165 170 175 Asn Glu Ile Phe Pro Ala Leu Gin Asp Ala Tyr Ala Gin Val Tyr Pro 180 185 190 Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 195 200 205 Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gin Arg Ala Leu 210 215 220 Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gin 225 230 235 240 Gin Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 245 250 255 Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 260 265 270 Thr Val Trp Asn Phe Ser Leu Gly Gin Leu Asp Asp Lys Trp Ala Gly 275 280 285 Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gin Ile 290 295 300 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Lys Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Ala Gin His His Glu 325 330 335 Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Thr Ala Lys Ala Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Page 2280 of 3790 Leu Ala Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Lys Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Ser Tyr 530 535 540 Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 545 550 555 560 Ser Phe Asp Gin Lys Gin Gin Val Leu Gly Glu Leu Phe Glu Arg His 565 570 575 Asn Thr Val Thr Ile Lys Gin Phe Val Asp Asn Leu Leu Ala His Gly 580 585 590 Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gin Leu Lys Gly Ile Leu His 610 615 620 Glu Ala Ile Asp Asp Ala Asp Lys Gin Thr Asp Ile Glu Asn Ile Ile 625 630 635 640 Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu Page 2282 of 3790 Page 2283 of 3790 1005 700 Page 2284 of 3790 PRT Lactobacillus casei Page 2285 of 3790 Gin Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 245 250 255 Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 260 265 270 Thr Ala Trp Asn Phe Ser Leu Gly Gin Leu Asp Asp Lys Trp Ala Gly 275 280 285 Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gin Ile 290 295 300 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Lys Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Glu Gin His His Glu 325 330 335 Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Met Ala Lys Ala Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Leu Val Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Gin Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 485 495 Page 2286 of 3790 490 Met Thr Lys Leu Gly Lys Pro Tyr Gly Ile Gly Val Asp Ile Gly Ser Page 2288 of 3790 Page 2289 of 3790 325 330 1008 1361 PRT Lactobacillus casei Asn Ser Ile Gly Phe Ala Ala Val Asp Glu Asn Ser His Leu Ile Arg 20 25 30 Page 2290 of 3790 Leu Lys Gly Lys Thr Val Ile Gly Ala Arg Leu Phe Glu Glu Gly Lys 35 40 45 Ala Ala Ala Asp Arg Arg Ala Ser Arg Thr Thr Arg Arg Arg Leu Ser 50 55 60 Arg Asn Arg Trp Arg Leu Ser Phe Leu Arg Asp Phe Phe Glu Ser His 65 70 75 80 Ile Thr Pro Thr Gly Pro Asn Phe Phe Met Arg Gin Lys Tyr Ser Glu 85 90 95 Ile Ser Pro Lys Asp Lys Ala Arg Tyr Lys Tyr Glu Lys Arg Leu Phe 100 105 110 Asn Asp Arg Thr Asp Ala Glu Phe Tyr Gin Gin Tyr Pro Thr Met Tyr 115 120 125 His Leu Arg Asn Arg Leu Leu Thr Asp Pro Ser Lys Ala Asp Val Arg 130 135 140 Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 145 150 155 160 Leu Thr Ser Gly Tyr Ala Lys Asp Phe Asn Thr Asn Lys Val Ala Leu 165 170 175 Asn Glu Ile Phe Pro Ala Leu Gin Asp Ala Tyr Ala Gin Val Tyr Pro 180 185 190 Asp Leu Asp Ile Thr Phe Asp Glu Asn Lys Val Asn Glu Phe Lys Thr 195 200 205 Val Leu Leu Asn Glu Lys Ala Thr Pro Ser Asp Thr Gin Arg Ala Leu 210 215 220 Val Asn Leu Leu Leu Ala Glu Asp Gly Asp Lys Asp Ile Leu Lys Gin 225 230 235 240 Gin Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 245 250 255 Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 260 265 270 Thr Val Trp Asn Phe Ser Leu Gly Gin Leu Asp Asp Lys Trp Ala Gly 275 280 285 Page 2291 of 3790 Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gin Ile 290 295 300 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Asn Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Ala Gin His His Glu 325 330 335 Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Thr Ala Lys Ala Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Leu Ala Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ser Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Lys Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Arg Tyr 530 535 540 Page 2292 of 3790 Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 545 550 555 560 Ser Ile Glu Gin Lys Gin Gin Val Ile Arg Glu Leu Phe Glu Arg His 565 570 575 Asn Ser Val Thr Ile Lys Gin Phe Ala Glu Asn Leu Arg Ala His Gly 580 585 590 Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gin Leu Lys Ser Leu Leu Pro 610 615 620 Asp Ala Ile Asp Asp Pro Ala Lys Gin Ala Asp Ile Glu Asn Ile Ile 625 630 635 640 Ala Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Lys Leu 645 650 655 Lys Glu Ile Asn Trp Leu Asp Ser Gin Thr Ile Thr Lys Leu Ser Asn 660 665 670 Ile Arg Tyr Arg Gly Trp Gly Gin Phe Ser His Lys Phe Leu Asn Gly 675 680 685 Leu Thr Leu Gly Asn Gly His Thr Ile Ile Gin Glu Leu Phe Leu Ser 690 695 700 Asn Asn Asn Leu Met Gin Ile Leu Thr Asp Glu Thr Leu Gin Lys Lys 705 710 715 720 Met Thr Glu Leu Asn Ala Asp Lys Leu Lys Ala Ala Asn Ile Asn Asp 725 730 735 Ala Ile Asp Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 740 745 750 Gin Val Leu Arg Val Ile Glu Asp Ile Lys Arg Ala Ala Asp Gly Gin 755 760 765 Asp Pro Ser Trp Leu Tyr Val Glu Thr Ala Asp Gly Gly Gly Thr Pro 770 775 780 Gly Lys Arg Thr Arg Ala Arg Gin His Gin Leu Gin Glu Ile Tyr Ala Phe Leu Ala Ala Arg Ile Gly Thr Tyr Leu Leu Lys Arg Phe Pro Asn 995 1000 1005 Leu Gin Ala Phe Phe Thr Tyr Gly Lys Phe Lys Lys Ala Asp Val 1010 1015 1020 Lys Lys Leu Arg Gly Phe Asn Phe Ile Arg Asp Ile Thr His Ala 1025 1030 1035 Page 2295 of 3790 1009 1128 PRT Lactobacillus casei Page 2296 of 3790 His Leu Arg Asn Arg Leu Met Thr Asp Pro Ser Arg Ala Asp Val Arg 130 135 140 Glu Ile Tyr Phe Ala Ile His His Ile Leu Lys Ser Arg Gly His Phe 145 150 155 160 Leu Thr Pro Gly Asp Ala Lys Asp Phe Asn Thr Asn Asp Val Ala Leu 165 170 175 Asp Glu Ile Phe Pro Ala Leu Gin Asp Ala Tyr Ala Gin Val Tyr Pro 180 185 190 Asp Leu Gly Ile Thr Phe Asp Glu Asp Lys Ala Asn Glu Phe Lys Thr 195 200 205 Ile Leu Leu Asn Glu Ile Ala Thr Ser Ile Asp Thr Gin Arg Ala Leu 210 215 220 Val Lys Leu Leu Leu Ala Glu Glu Asp Asp Lys Asp Ile Leu Lys Gin 225 230 235 240 Gin Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 245 250 255 Thr Lys Leu Asn Leu Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 260 265 270 Thr Ala Trp Asn Phe Ser Leu Gly Gin Leu Asp Asp Lys Trp Ala Gly 275 280 285 Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gin Ile 290 295 300 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Thr Gly 305 310 315 320 Lys Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Thr Gin His His Glu 325 330 335 Asp Leu Gin Leu Phe Lys Ala Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Thr Ala Lys Ala Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Asp Ala Ala Pro Phe Leu Arg Glu Asn Phe Val Lys Ala Leu Thr Lys 370 375 380 Page 2297 of 3790 Asp Val Thr Ala His Pro Asn Thr Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Leu Ala Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ala Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Lys Ser Met Pro Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Glu 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Arg Tyr 530 535 540 Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asn Glu Lys Leu 545 550 555 560 Ser Ile Glu Gin Lys Gin Gin Val Ile Arg Glu Leu Phe Glu Arg His 565 570 575 Asn Ser Val Thr Ile Lys Gin Phe Ala Glu Asn Leu Arg Ala His Gly 580 585 590 Asp Tyr Ala His Ile Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr Arg Gin Leu Lys Ser Leu Leu Pro 610 615 620 Glu Ala Ile Asp Asp Pro Ala Lys Gin Ala Asp Ile Glu Asn Ile Ile Page 2299 of 3790 Phe Met Gly Ala Ile Ser Glu Arg Thr Arg Pro Ile Leu Pro Leu 1115 1120 1125 Page 2300 of 3790 1010 1366 PRT Lactobacillus casei 1010 Page 2301 of 3790 Val Asn Leu Leu Leu Ala Lys Glu Gly Asp Arg Asp Ile Leu Lys Gin 225 230 235 240 Gin Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Val Val Gly Leu Lys 245 250 255 Thr Lys Leu Asn Val Ala Leu Gly Thr Glu Val Asp Ser Ser Glu Ala 260 265 270 Thr Ala Trp Asn Phe Ser Leu Gly Gin Leu Asp Asp Lys Trp Ala Gly 275 280 285 Ile Glu Ser Ala Met Thr Asp Glu Gly Thr Glu Ile Leu Asp Gin Ile 290 295 300 Arg Asp Leu Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Lys Thr Leu Ser Gin Ala Lys Val Asp Asp Tyr Ala Gin His His Glu 325 330 335 Asp Leu Glu Leu Phe Lys Asp Tyr Leu Lys Gin Leu Glu Asp Asp Gly 340 345 350 Thr Ala Lys Ala Ile Arg Gin Leu Tyr Asp Arg Tyr Ile Asp Gly Asp 355 360 365 Asp Ala Lys Pro Phe Val Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Ala Lys Ser Pro Glu Leu Leu Glu Arg 385 390 395 400 Leu Ala Gin Pro Asp Phe Met Leu Lys Gin Arg Asn Lys Ala Asn Gly 405 410 415 Ala Ile Pro Val Gin Met Gin Gin Arg Glu Leu Asp Gin Ile Ile Lys 420 425 430 Asn Gin Ala Val Tyr Tyr Asp Trp Leu Ala Ala Pro Asn Pro Val Glu 435 440 445 Lys His Arg Gin Ser Met Thr Tyr Gin Leu Asp Glu Leu Leu Asn Phe 450 455 460 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Thr Ala Lys Glu Gin Lys 465 470 475 480 Page 2302 of 3790 Ala Ala Gin Gly Gly Val Phe Ala Trp Met Val Arg Lys Asp Pro Asp 485 490 495 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Arg Glu Ala 500 505 510 Ser Ala Asn Thr Phe Ile Gin Arg Met Lys Thr Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Gin Ser Leu Leu Tyr Gin Ser Tyr 530 535 540 Glu Val Leu Asn Glu Leu Asn Asn Val Arg Val Asn Asp Asn Lys Leu 545 550 555 560 Ser Phe Asp Gin Lys Gin Gin Val Leu Gly Glu Leu Phe Glu Arg His 565 570 575 Asn Thr Val Thr Ile Lys Gin Phe Val Asp Asn Leu Leu Ala His Gly 580 585 590 Asp Tyr Asp Arg Ile Pro Glu Val Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr Asn Gin Leu Lys Gly Ile Leu His 610 615 620 Glu Ala Ile Asp Asp Ala Asp Lys Gin Thr Asp Ile Glu Asn Ile Ile 625 630 635 640 Ala Trp Ser Thr Ile Phe Glu Asp Lys Ala Ile Phe Lys Thr Lys Leu 645 650 655 Asn Glu Ile Ser Trp Leu Asn Ala Gly Met Ile Asn Ser Leu Ala Asn 660 665 670 Ile Arg Tyr Arg Gly Trp Gly Gin Phe Ser His Lys Leu Leu Asn Glu 675 680 685 Leu Thr Leu Ser Thr Gly Arg Thr Val Phe Glu Glu Leu Leu Ile Ser 690 695 700 Ser Arg Asn Leu Met Gin Ile Leu Thr Asp Glu Val Leu Lys Gin Lys 705 710 715 720 Ile Ala Glu Leu Asn Ala His Glu Leu Lys Ala Ser Gly Ile Tyr Ala Ala Val Lys Ala Gly Leu Ser Ser Gin Leu Arg Lys Glu Leu Asp Phe 965 970 975 Page 2304 of 3790 Pro Lys Asn Arg Glu Val Asn His Tyr His His Ala Phe Asp Ala Phe 980 985 990 Leu Ala Ala Arg Ile Gly Thr Tyr Leu Leu Lys Arg Tyr Pro Asn Leu 995 1000 1005 Page 2305 of 3790 1011 1354 PRT Lactobacillus coryniformis Page 2306 of 3790 Trp Arg Leu Arg Leu Leu Gin Asp Phe Phe Glu Pro Tyr Ile Leu Pro 65 70 75 80 Gin Asp Asp Gly Phe Phe Ile Arg Arg Lys Glu Ser Asn Leu Val Leu 85 90 95 Asn Asp Arg Asp Glu Asp Thr Ala Ser Leu Phe Asn Asp Arg Ser Asp 100 105 110 Arg Asp Phe Tyr Gin Ala Tyr Pro Thr Ile Tyr His Leu Arg Gin Ala 115 120 125 Leu Met Thr Glu Lys Arg Gin Phe Asp Val Arg Glu Ile Tyr Leu Ala 130 135 140 Met His His Ile Ile Lys Tyr Arg Gly His Phe Leu Leu Asn Gly Thr 145 150 155 160 Val Asn Asn Phe Thr Asn Asn Lys Ile Asp Leu His Ser Asp Phe Glu 165 170 175 Glu Leu Asn Ala Leu Leu Leu Asn Val Ile Pro Glu Leu Lys Phe Gin 180 185 190 Ile Asp Leu Asp His Ser Thr Met Phe Gin Thr Thr Leu Leu Asn Thr 195 200 205 Thr Ile Ser Arg Ser Gly Arg Gin Arg Asp Leu Val Lys Ser Phe Tyr 210 215 220 Asn Gly Ser Asp Asp Lys Gin Leu Ala Lys Gin Gin Lys Ser Val Ala 225 230 235 240 Thr Glu Leu Leu Lys Ala Ile Leu Gly Leu Lys Ala Lys Phe His Lys 245 250 255 Leu Phe Asn Leu Asp Leu Leu Glu Thr Thr Glu Trp Glu Phe Ser Phe 260 265 270 Asp Ala Glu Asp Ile Asp Asp Lys Leu Ala Lys Leu Glu Pro Leu Met 275 280 285 Thr Glu Asn Gin Gin Gin Val Met Asp Ile Leu Gin Arg Ile Phe Ala 290 295 300 Ala Ile Thr Leu Asn Gly Ile Val Pro Glu Gly Lys Thr Leu Ser Ala 305 310 315 320 Page 2307 of 3790 Ser Lys Val Asp Ser Tyr Gin Lys His Lys Gin Asp Leu Lys Leu Leu 325 330 335 Lys Ala Ile Ala Gin His Ser Asp Lys Lys Thr Ala Thr Val Leu Gin 340 345 350 Thr Ala Tyr Asn Glu Tyr Ile Asn Gly Ile Ala Ser Lys Pro Leu Lys 355 360 365 Gin Glu Asp Phe Tyr Lys Arg Leu Thr Asn Ala Val Lys Lys Ser Ser 370 375 380 Asp Pro Gin Val Ala Asp Met Leu Ala Leu Ile Asp Gin Glu Lys Phe 385 390 395 400 Leu Pro Lys Gin Arg Thr Lys Glu Asn Gly Ala Ile Pro His Gin Leu 405 410 415 His Gin Leu Glu Leu Glu Arg Ile Ile Asp Asn Gin Lys Asp Tyr Tyr 420 425 430 Pro Trp Leu Ala Glu Leu Asn Pro Asn Gin Ala Arg Gin Lys Val Ala 435 440 445 Lys Tyr Lys Leu Ser Glu Leu Val Ala Phe Arg Val Pro Tyr Tyr Val 450 455 460 Gly Pro Leu Ile Glu Pro Glu Val Gin Gin Ala Thr Ser Asn Ala His 465 470 475 480 Phe Ala Trp Met Ala Arg Lys Glu Ala Gly Pro Ile Thr Pro Trp Asn 485 490 495 Phe Asp Gin Lys Val Asp Arg Asn Val Ser Ala Glu Arg Phe Ile Lys 500 505 510 Arg Met Thr Thr Lys Asp Thr Tyr Leu Leu Ala Glu Asp Val Leu Pro 515 520 525 Leu His Ser Leu Leu Tyr Gin Arg Phe Ile Val Leu Asn Glu Leu Asn 530 535 540 Asn Val Arg Val Asn Gly Gin Lys Leu Thr Lys Lys Gin Lys Gin Ala 545 550 555 560 Val Tyr Gin Asp Leu Phe Lys Arg Gin Pro His Val Thr Lys Lys Gin Page 2309 of 3790 Page 2310 of 3790 Page 2311 of 3790 Arg 1012 544 PRT Lactobacillus crispatus Page 2312 of 3790 Tyr Lys Ser Arg Glu Val Asn Asp Tyr His His Ala Ile Asp Ala Tyr 165 170 175 Leu Thr Thr Ile Cys Gly Asn Leu Leu Tyr Gin Ala Tyr Pro Lys Leu 180 185 190 Arg Pro Phe Phe Val Tyr Gly Gin Phe Lys Lys Phe Ser Ser Asp Pro 195 200 205 Lys Lys Glu Asn Glu Ile Leu Lys Lys Thr Lys Asn Phe Asp Phe Val 210 215 220 Ala Lys Leu Leu Gly Ser Lys Ala Pro Asn Glu Ile Arg Ser Gin Gin 225 230 235 240 Gly Lys Val Leu Phe Glu Lys Asn Lys Ile Arg Leu Gin Leu Asn Lys 245 250 255 Ala Tyr Asn Tyr Lys Tyr Met Leu Val Ser Arg Asp Thr Thr Thr Lys 260 265 270 Asn Gin Glu Met Phe Gly Met Thr Ile Tyr Pro Arg Ala Glu Arg Asp 275 280 285 Ile Ala Lys Ser Arg Lys Leu Ile Glu Lys Arg Lys Gly Phe Ser Thr 290 295 300 Asp Ile Tyr Gly Gly Tyr Thr Gly Thr Ala Ala Ala Tyr Met Ala Ile 305 310 315 320 Val Arg Ile Asn Lys Thr Lys Ser Ser Gin Tyr Lys Val Ile Ala Val 325 330 335 Pro Met Thr Lys Arg Ala Ile Leu Asn Lys Ala Glu Lys Glu Gly Asn 340 345 350 Tyr Glu Lys Ile Leu Lys Gin Ile Leu Ser Pro Ser Ile Leu Tyr Asn 355 360 365 Asp Lys Gly Lys Arg Lys Ala Gly Val Ile Ser Phe Asp Ile Ile Lys 370 375 380 Gly Lys Val Pro Tyr Asn Gin Val Val Gin Asp Gly Asn Lys Lys Phe 385 390 395 400 Leu Leu Lys Ser Ala Ile Tyr Leu Cys Asn Ala Lys Gin Leu Val Leu 405 415 Page 2313 of 3790 410 1013 298 PRT Lactobacillus crispatus Lys Leu Asp Ser Asn Glu Phe Arg Asp Asp Phe Glu Lys Ile Ile Glu 290 295 1014 279 PRT Lactobacilius crispatus 1014 Met Asn Gly Lys Lys Leu Ser Val Ser Val Lys Gin Glu Leu Tyr Glu Page 2316 of 3790 Asn Leu Lys Asp Lys Leu Ala Glu Tyr Ile Lys Asn Asn Gin Leu Asn 260 265 270 Lys Asp Lys Tyr Tyr Thr Arg 275 1015 538 PRT Lactobacillus crispatus Page 2317 of 3790 Gly Gin Phe Lys Lys Phe Ser Ser Asp Pro Lys Lys Glu Asn Glu Ile 195 200 205 Leu Lys Lys Thr Lys Asn Phe Asp Phe Val Ala Lys Leu Leu Gly Ser 210 215 220 Lys Ala Pro Asn Glu Ile Arg Ser Gin Gin Gly Lys Val Leu Phe Glu 225 230 235 240 Lys Asn Lys Ile Arg Leu Gin Leu Asn Lys Ala Tyr Asn Tyr Lys Tyr 245 250 255 Met Leu Val Ser Arg Asp Thr Thr Thr Lys Asn Gin Glu Met Phe Gly 260 265 270 Met Thr Ile Tyr Pro Arg Ala Glu Arg Asp Ile Ala Lys Ser Arg Lys 275 280 285 Leu Ile Glu Lys Arg Lys Gly Phe Ser Thr Asp Ile Tyr Gly Gly Tyr 290 295 300 Thr Gly Thr Ala Ala Ala Tyr Met Ala Ile Val Arg Ile Asn Lys Thr 305 310 315 320 Lys Ser Ser Gin Tyr Lys Val Ile Ala Val Pro Met Thr Lys Arg Ala 325 330 335 Ile Leu Asn Lys Ala Glu Lys Glu Gly Asn Tyr Glu Lys Ile Leu Lys 340 345 350 Gin Ile Leu Ser Pro Ser Ile Leu Tyr Asn Asp Lys Gly Lys Arg Lys 355 360 365 Ala Gly Val Ile Ser Phe Asp Ile Ile Lys Gly Lys Val Pro Tyr Asn 370 375 380 Gin Val Val Gin Asp Gly Asn Lys Lys Phe Leu Leu Lys Ser Ala Ile 385 390 395 400 Tyr Leu Cys Asn Ala Lys Gin Leu Val Leu Ser Glu Glu Ala Met Arg 405 410 415 Val Ile Thr Gly His Trp Leu Asp Ser Asp Lys Gin Asp Gin Glu Leu 420 425 430 Leu Asp Val Tyr Asp Glu Ile Leu Glu Lys Ile Asp Arg Tyr Leu Pro 435 440 445 Page 2318 of 3790 Page 2319 of 3790 Page 2320 of 3790 Ala Ile Tyr Ile Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe 145 150 155 160 Leu Ser Asn Ser Ser Ile Ser Asn Phe Ser Ala Ser Lys Ile Glu Ile 165 170 175 Asp Arg Phe Val Asn Glu Leu Asn Asp Leu Tyr Ser Ile Phe Leu Pro 180 185 190 Glu Ser Gly Val Ile Phe Asp Ala Gly Asn Ala Ser Lys Val Glu Asp 195 200 205 Ile Ile Arg Asn Glu Gin Met Phe Lys Leu Asp Lys Ile Lys Glu Ile 210 215 220 Ala Asp Val Leu Pro Asp Thr Glu Asn Lys Ser Gly Leu Lys Leu Ser 225 230 235 240 Lys Lys Ile Ser Lys Glu Ile Ser Lys Ala Ile Leu Gly Tyr Lys Ala 245 250 255 Lys Phe Glu Ile Ile Leu Gin Val Asn Val Asp Lys Thr Asp Ser Ser 260 265 270 Ile Trp Asn Phe Lys Leu Asn Asp Glu Asn Ala Asp Val Asn Leu Ser 275 280 285 Glu Ile Thr Ser Asp Leu Thr Asp Thr Gin Leu Gin Ile Leu Asp Leu 290 295 300 Val Arg Asn Leu Phe Ser Ala Ile Ser Leu Leu Asn Ile Val Asp Glu 305 310 315 320 Gly Ser Thr Leu Ser Glu Ser Met Ile Arg Lys Tyr Asn Asp His Ala 325 330 335 Gin Asp Leu Lys Leu Leu Lys Thr Val Ile Lys Asn His Ser Asp Arg 340 345 350 Lys Lys Ala His Asn Leu Gin Leu Ala Tyr Asp Lys Tyr Val Asn Asn 355 360 365 Arg His Phe Val Asp Val Glu Thr Lys Lys Ala Phe Pro Asn Lys His 370 375 380 Leu Tyr Arg Lys Ser Asp Phe Tyr Glu Ile Val Lys Lys Asn Leu Asp 385 390 395 400 Page 2321 of 3790 Ala Ser Lys Glu Ala Val Gin Ile Arg Lys Glu Ile Ala Leu Asp Lys 405 410 415 Phe Met Pro Lys Gin Arg Ser Asp Glu Asn Gly Val Ile Pro Phe Gin 420 425 430 Leu Asn Gin Ile Glu Leu Asp Lys Ile Ile Glu Asn Gin Gly Lys Tyr 435 440 445 Tyr Pro Phe Leu Lys Glu Ile Asn Pro Ile Lys Ala His Arg Met Gin 450 455 460 Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr Tyr 465 470 475 480 Val Gly Pro Met Ile Glu Pro Thr Asn Ser Ser Tyr Pro Gin Thr Arg 485 490 495 Gin Asn Gin Ser Phe Ala Trp Met Val Arg Lys Ala Lys Gly Arg Ile 500 505 510 Thr Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Gin Lys Ser Ala Asn 515 520 525 Asn Phe Ile Lys Arg Leu Thr Thr Lys Asp Thr Tyr Leu Phe Gly Glu 530 535 540 Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gin Lys Tyr Thr Val Leu 545 550 555 560 Asp Glu Leu Asn Lys Ile Ser Val Asn Gly Lys Lys Leu Ser Val Ser 565 570 575 Val Lys Gin Glu Leu Tyr Glu Asp Leu Phe Lys Lys Asn Asn Thr Val 580 585 590 Ser Ala Lys Gin Leu Lys Asn Trp Leu Ile Glu Asn Gin Lys Leu Pro 595 600 605 Tyr Ile Lys Ile Lys Gly Leu Ala Asp Gin Thr Lys Phe Asn Ser Ser 610 615 620 Leu Ser Thr Tyr Ile Lys Leu Lys Lys Ser Gly Leu Phe Val Asp Lys 625 630 635 640 Leu Asp Ser Asn Glu Phe Arg Asp Asp Phe Glu Lys Ile Ile Glu Trp 645 655 Page 2322 of 3790 650 Met Thr Lys Leu Asn Asn Glu Tyr Met Val Gly Leu Asp Ile Gly Thr Page 2324 of 3790 Lys Phe Glu Ile Ile Leu Gin Val Asn Val Asp Lys Thr Asp Ser Ser 260 265 270 Ile Trp Asn Phe Lys Leu Asn Asp Glu Asn Ala Asp Val Asn Leu Ser 275 280 285 Glu Ile Thr Ser Asp Leu Thr Asp Thr Gin Leu Gin Ile Leu Asp Leu 290 295 300 Val Arg Asn Leu Phe Ser Ala Ile Ser Leu Leu Asn Ile Val Asp Glu 305 310 315 320 Gly Ser Thr Leu Ser Glu Ser Met Ile Arg Lys Tyr Asn Asp His Ala 325 330 335 Gin Asp Leu Lys Leu Leu Lys Thr Val Ile Lys Asn His Ser Asp Arg 340 345 350 Lys Lys Ala His Asn Leu Gin Leu Ala Tyr Asp Lys Tyr Val Asn Asn 355 360 365 Arg His Phe Val Asp Val Glu Thr Lys Lys Ala Phe Pro Asn Lys His 370 375 380 Leu Tyr Arg Lys Ser Asp Phe Tyr Glu Ile Val Lys Lys Asn Leu Asp 385 390 395 400 Ala Ser Lys Glu Ala Val Gin Ile Arg Lys Glu Ile Ala Leu Asp Lys 405 410 415 Phe Met Pro Lys Gin Arg Ser Asp Glu Asn Gly Val Ile Pro Phe Gin 420 425 430 Leu Asn Gin Ile Glu Leu Asp Lys Ile Ile Glu Asn Gin Gly Lys Tyr 435 440 445 Tyr Pro Phe Leu Lys Glu Ile Asn Pro Ile Lys Ala His Arg Met Gin 450 455 460 Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr Tyr 465 470 475 480 Val Gly Pro Met Ile Glu Pro Thr Asn Ser Ser Tyr Pro Gin Thr Arg 485 490 495 Gin Asn Gin Ser Phe Ala Trp Met Val Arg Lys Ala Lys Gly Arg Ile 500 505 510 Page 2325 of 3790 Thr Pro Trp Asn Phe Asp Glu Lys Val Asp Arg Gin Lys Ser Ala Asn 515 520 525 Asn Phe Ile Lys Arg Leu Thr Thr Lys Asp Thr Tyr Leu Phe Gly Glu 530 535 540 Asp Val Leu Pro Ala Asn Ser Leu Leu Tyr Gin Lys Tyr Thr Val Leu 545 550 555 560 Asp Glu Leu Asn Lys Ile Ser Val Asn Gly Lys Lys Leu Ser Val Ser 565 570 575 Val Lys Gin Glu Leu Tyr Glu Asp Leu Phe Lys Lys Asn Asn Thr Val 580 585 590 Ser Ala Lys Gin Leu Lys Asn Trp Leu Ile Glu Asn Gin Lys Leu Pro 595 600 605 Tyr Ile Lys Ile Lys Gly Leu Ala Asp Gin Thr Lys Phe Asn Ser Ser 610 615 620 Leu Ser Thr Tyr Ile Lys Leu Lys Lys Ser Gly Leu Phe Val Asp Lys 625 630 635 640 Leu Asp Ser Asn Glu Phe Arg Asp Asp Phe Glu Lys Ile Ile Glu Trp 645 650 655 Ser Thr Ile Phe Glu Asp Lys Gin Ile Tyr Ile Gin Lys Leu Gin Thr 660 665 670 Ile Asp Trp Leu Thr Ala Lys Gin Ile Gin Phe Leu Gin Asn Ile Arg 675 680 685 Leu Gin Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Ala Ile Val 690 695 700 Asp Ser Asn Gly Gin Asn Ile Ile Glu Gin Leu Trp Asn Ser Gin Gin 705 710 715 720 Ile Phe Met Ser Ile Val Asn Lys Ala Asp Ile Lys Gly Thr Ile Thr 725 730 735 Asp Ala Asn Gin Asp Leu Met His Ser Asn Ser Met Glu Asp Ile Leu 740 745 750 Ser Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Met Ile Arg Gin Val 755 760 765 Page 2326 of 3790 Page 2327 of 3790 Page 2328 of 3790 Arg Leu Gin Leu Asn Lys Ala Tyr Asn Tyr Lys Tyr Met Leu Val Ser Page 2330 of 3790 Page 2331 of 3790 Page 2332 of 3790 Page 2333 of 3790 Glu Arg Arg Ser Phe Arg Thr Thr Arg Arg Arg Leu Lys Arg Arg Lys 50 55 60 Trp Arg Leu Gly Leu Leu Arg Glu Ile Phe Glu Pro Tyr Ile Thr Pro 65 70 75 80 Ile Asp Asp Thr Phe Phe Leu Arg Gin Lys Gin Ser Asn Leu Ser Pro 85 90 95 Lys Asp Gin Arg Lys Leu Tyr Thr Gin Thr Ser Leu Phe Asn Asp Arg 100 105 110 Thr Asp Arg Ala Phe Tyr Asp Asp Tyr Pro Thr Ile Tyr His Leu Arg 115 120 125 Tyr Arg Leu Met Thr Glu Lys Arg Gin Phe Asp Ile Arg Glu Ile Tyr 130 135 140 Leu Ala Met His His Ile Val Lys Tyr Arg Gly His Phe Leu Asn Glu 145 150 155 160 Ala Pro Val Ser Ser Phe Lys Ser Ser Glu Ile Asn Leu Val Ala His 165 170 175 Phe Asp Arg Leu Asn Thr Ile Phe Ala Asp Leu Phe Ser Glu Ser Gly 180 185 190 Phe Gin Leu Glu Thr Asp Lys Leu Ala Glu Val Lys Ala Leu Leu Leu 195 200 205 Asp Asn Gin Gin Ser Ala Ser Asn Arg Gin Arg Gin Ala Leu Ser Leu 210 215 220 Ile Tyr Thr Pro Ser Thr Asn Lys Ala Val Glu Lys Gin Asn Lys Ala 225 230 235 240 Ile Ala Thr Glu Leu Leu Lys Ala Ile Leu Gly Leu Lys Ala Lys Phe 245 250 255 Asn Val Leu Thr Gly Ile Glu Ala Glu Asp Val Lys Ala Trp Thr Leu 260 265 270 Thr Phe Asn Ala Glu Asn Phe Asp Glu Glu Met Val Lys Leu Glu Ser 275 280 285 Ser Leu Asp Asp Asn Ala His Gin Ile Ile Glu Ser Leu Gin Glu Leu 290 295 300 Page 2334 of 3790 Tyr Ser Gly Val Leu Leu Ala Gly Ile Val Pro Glu Asn Gin Ser Leu 305 310 315 320 Ser Gin Ala Met Ile Thr Lys Tyr Asp Asp His Gin Lys His Leu Lys 325 330 335 Met Leu Lys Ala Val Arg Glu Ala Leu Ala Pro Gly Asp Arg Gin Arg 340 345 350 Leu Lys Gin Ala Tyr Asp Gin Tyr Val Asp Gly Gin Glu Asn Thr Lys 355 360 365 Ala Tyr Ser Lys Glu Asp Phe Tyr Gly Asp Ile Thr Lys Ala Leu Lys 370 375 380 Asn Asn Pro Asp His Pro Ile Val Ser Glu Ile Lys Lys Leu Ile Glu 385 390 395 400 Leu Asp Gin Phe Met Pro Lys Gin Arg Thr Lys Asp Asn Gly Ala Ile 405 410 415 Pro His Gin Leu His Gin Gin Glu Leu Asp Arg Ile Ile Glu Asn Gin 420 425 430 Gin Gin Tyr Tyr Pro Trp Leu Ala Glu Leu Asn Pro Asn Ser Lys Arg 435 440 445 Gin Thr Val Ala Lys Tyr Lys Leu Asp Glu Leu Val Ala Phe Arg Val 450 455 460 Pro Tyr Tyr Val Gly Pro Leu Ile Thr Ala Glu Gin Gin Arg Gin Ser 465 470 475 480 Ser Asp Ala Lys Phe Ala Trp Leu Ile Arg Lys Ala Glu Gly Arg Ile 485 490 495 Thr Pro Trp Asn Phe Asp Asp Lys Val Asp Arg Gin Ala Ser Ala Asn 500 505 510 Glu Phe Ile Lys Arg Met Thr Thr Thr Asp Thr Tyr Leu Leu Ala Glu 515 520 525 Asp Val Leu Pro Lys Gin Ser Leu Ile Tyr Gin Arg Phe Glu Val Leu 530 535 540 Asn Glu Leu Asn Gly Leu Lys Ile Asp Asp Gin Pro Ile Thr Thr Glu 545 550 555 560 Page 2335 of 3790 Leu Lys Gin Ala Ile Phe Thr Asp Leu Phe Met Gin Lys Ile Ser Val 565 570 575 Thr Val Lys Asn Ile Gin Asp Tyr Leu Val Ser Glu Lys Arg Tyr Ala 580 585 590 Ser Arg Pro Ala Ile Thr Gly Leu Ser Asp Glu Asn Lys Phe Asn Ser 595 600 605 Arg Leu Ser Thr Tyr His Asp Leu Lys Met Ile Val Gly Asp Ala Val 610 615 620 Asp Asp Val Asp Lys Gin Ala Asp Leu Glu Lys Cys Ile Glu Trp Ser 625 630 635 640 Thr Ile Phe Glu Asp Gly Lys Ile Tyr Ser Ala Lys Leu Asn Glu Ile 645 650 655 Asp Trp Leu Thr Asp Gin Gin Arg Val Gin Leu Ala Ala Lys Arg Tyr 660 665 670 Arg Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Thr Gin Ile Val Asn 675 680 685 Ala Asn Gly Gin Arg Ile Met Asp Leu Leu Trp Asp Thr Thr Asp Asn 690 695 700 Phe Met Arg Ile Val His Ser Glu Asp Phe Asp Lys Leu Ile Thr Glu 705 710 715 720 Ala Asn Gin Met Met Leu Ala Glu Asn Asp Val Gin Asp Val Ile Asn 725 730 735 Asp Leu Tyr Thr Ser Pro Gin Asn Lys Lys Ala Leu Arg Gin Ile Leu 740 745 750 Leu Val Val Asn Asp Ile Gin Lys Ala Met Lys Gly Gin Ala Pro Glu 755 760 765 Arg Ile Leu Ile Glu Phe Ala Arg Glu Asp Glu Val Asn Ser Arg Leu 770 775 780 Ser Val Gin Arg Lys Arg Gin Val Glu Gin Val Tyr Gin Asn Ile Ser 785 790 795 800 Asn Glu Leu Leu Asn Asn Thr Glu Ile Arg Asn Glu Leu Lys Asp Leu 805 815 Page 2336 of 3790 810 Page 2338 of 3790 1024 669 PRT Lactobacillus delbrueckii Page 2339 of 3790 Ile Tyr Ile Ala Val His Gin Met Ile Lys Ala Arg Gly Asn Phe Leu 145 150 155 160 His Asp Glu Ser Val Glu Thr Tyr Arg Ser Gly Met Ser Ser Leu Gly 165 170 175 Gly Arg Ser Glu Arg Asn Ile Leu Ser Val Gin Thr Leu Glu Glu Leu 180 185 190 Asn Asp Leu Phe Ala Glu Asn Glu Gly Thr Glu Glu Val Glu Leu Asn 195 200 205 Val Ala Ser Ala Glu Gin Ile Asn Asp Ile Leu Thr Gly Gly His Leu 210 215 220 Asn Ala Asp Ser Gin Lys Glu Ile Ser Asn Leu Leu Leu Pro Ser Ser 225 230 235 240 Phe Pro Ser Phe Asp Asp Lys Ala Lys Glu Lys Gin Val Lys Lys Leu 245 250 255 Ile Asn Asn Val Ala Thr Asn Ile Ser Lys Ala Trp Leu Gly Tyr Lys 260 265 270 Ala Asp Phe Ser Thr Ile Leu Asn Leu Ala Lys Val Asp Lys Asp Gin 275 280 285 Lys Lys Ile Phe Ala Phe Ala Leu Gin Gly Gly Asp Glu Glu Asp Lys 290 295 300 Val Gin Glu Leu Glu Ser Leu Leu Glu Gin Ser Gin Thr Asp Ile Val 305 310 315 320 Asp Arg Leu Ile Glu Ile Arg His Ala Ile Val Leu Ser Glu Ile Val 325 330 335 Pro Val Gly Met Thr Leu Ser Glu Ala Met Ile Asp Lys Tyr Asp Gin 340 345 350 His Lys Glu Asp Leu Ile Thr Leu Lys Ala Val Ile Arg Asn Thr Lys 355 360 365 Asp Lys Lys Lys Ala Ala Lys Leu Gin Ala Ile Tyr Asp Leu Tyr Val 370 375 380 Lys Lys Arg His Ala Asp Leu Ala Lys Ala Met Lys Leu Thr Gly Ile 385 390 395 400 Page 2340 of 3790 Lys Lys Arg Ser Glu Leu Leu Asp Pro Glu Glu Leu Lys Lys Gly Ile 405 410 415 Ser Ser Leu Leu Asp Asp Ser Pro Glu Ala Val Glu Ile Lys Gin Arg 420 425 430 Leu Glu Glu Lys Thr Phe Leu Pro Leu Gin Arg Ser Asn Asn Asn Gly 435 440 445 Val Ile Pro Asn Gin Leu His Gin Val Glu Leu Asp Glu Ile Ile Lys 450 455 460 Lys Gin Ser Lys Tyr Tyr Pro Phe Leu Ala Glu Lys Asn Pro Asp Glu 465 470 475 480 Ser Glu Glu Ala Gin Lys Lys Ala Pro Thr Lys Leu Asp Ala Leu Leu 485 490 495 Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Met Ile Thr Lys Glu Glu 500 505 510 Gin Glu Ala Gin Asn Gly His Ser Phe Ala Trp Met Val Arg Arg Asp 515 520 525 Pro Gin Asp His Glu Ala Ile Thr Pro Trp Asn Phe Glu Lys Lys Val 530 535 540 Asp Lys Met Ala Ser Ala Thr Gin Phe Ile Lys Arg Met Thr Thr Lys 545 550 555 560 Asp Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Ala Ser Ser Leu Lys 565 570 575 Tyr Gin Leu Phe Thr Val Leu Asn Glu Leu Asn Asn Leu Arg Val Asn 580 585 590 Gly Lys Lys Leu Thr Ser Asp Glu Lys Glu Gin Val Ile Glu Gly Leu 595 600 605 Phe Lys Lys Gin Lys Thr Val Lys Ala Asp Lys Phe Val Lys Tyr Trp 610 615 620 Gin Ala Lys His Ile Gly Ala Asp Ile Lys Val Lys Gly Leu Ser Asp 625 630 635 640 Pro Ser Lys Phe Asn Ser Thr Met Ser Thr Tyr Ile Asp Phe Lys Lys Page 2341 of 3790 645 650 655 Ile Phe Gly Asp Gin Leu Asn Asp Val Asn Arg Gin Arg 660 665 1025 544 PRT Lactobacilius delbrueckii Asp Val Ala Arg Arg Val Lys Ser Met Asn Phe Leu Asp Asp Leu Leu Page 2342 of 3790 195 200 205 Arg Gly Thr His Gly Asp Asn Ile Tyr Cys Arg Ser Thr Gly Glu Ile 210 215 220 Val Phe Asn Arg Asn Asp Ile Ile Ser Lys Leu Lys Gin Ala Tyr Ser 225 230 235 240 Phe Lys Gin Met Leu Val Thr Gin Glu Val Phe Thr Lys Lys Ser Ala 245 250 255 Leu Phe Asp Gin Thr Val Tyr Pro Ser Pro Glu Arg Asp Ser Lys Lys 260 265 270 Arg Ser Gly Leu Ile Pro Arg Lys Lys Gly Met Asp Thr Glu Ile Tyr 275 280 285 Gly Gly Tyr Ser Gly Asn Lys Asp Ala Tyr Phe Val Leu Ala Glu Ala 290 295 300 Val Lys Glu Lys Gly His Thr Leu Gin Ile Val Gly Val Pro Ile Arg 305 310 315 320 Ala Leu Asn Thr Leu Lys Asn Ser Ala Asn Tyr Ser Glu Lys Leu Leu 325 330 335 Glu Ile Ile Lys Pro Gin Val Met Phe Asn Lys Asp Thr Gly Lys Pro 340 345 350 Ile Lys Gly Ile Lys Asp Val Lys Ile Leu Met Asp Lys Ile Pro Cys 355 360 365 Arg Gin Pro Val Leu Glu Gly Glu Ser Tyr Tyr Met Leu Ala Ser Ser 370 375 380 Lys Tyr Arg Tyr Ser Leu Lys Gin Ile Ser Leu Ser Gin Met Ser Met 385 390 395 400 Lys Tyr Ile Leu Asp Tyr Ile Asp Asp Pro Asn Phe Asn Lys His Glu 405 410 415 Met Ile Asn Ile Asp Gin Gin Asp Glu Lys Glu Cys Leu Leu Ser Val 420 425 430 Tyr Asp Glu Ile Leu Glu Lys Met Asp Lys Tyr Leu Pro Leu Phe Asp 435 440 445 Page 2343 of 3790 530 535 540 1026 1356 PRT Lactobacillus farciminis Page 2344 of 3790 Ile Phe His Leu Arg Lys Glu Leu Ile Leu Asn Lys Asp Lys Ala Asp 130 135 140 Ile Arg Leu Ile Tyr Leu Ala Leu His Asn Ile Leu Lys Tyr Arg Gly 145 150 155 160 Asn Phe Thr Tyr Glu His Gin Lys Phe Asn Ile Ser Asn Leu Asn Asn 165 170 175 Asn Leu Ser Lys Glu Leu Ile Glu Leu Asn Gin Gin Leu Ile Lys Tyr 180 185 190 Asp Ile Ser Phe Pro Asp Asp Cys Asp Trp Asn His Ile Ser Asp Ile 195 200 205 Leu Ile Gly Arg Gly Asn Ala Thr Gin Lys Ser Ser Asn Ile Leu Lys 210 215 220 Asp Phe Thr Leu Asp Lys Glu Thr Lys Lys Leu Leu Lys Glu Val Ile 225 230 235 240 Asn Leu Ile Leu Gly Asn Val Ala His Leu Asn Thr Ile Phe Lys Thr 245 250 255 Ser Leu Thr Lys Asp Glu Glu Lys Leu Asn Phe Ser Gly Lys Asp Ile 260 265 270 Glu Ser Lys Leu Asp Asp Leu Asp Ser Ile Leu Asp Asp Asp Gin Phe 275 280 285 Thr Val Leu Asp Ala Ala Asn Arg Ile Tyr Ser Thr Ile Thr Leu Asn 290 295 300 Glu Ile Leu Asn Gly Glu Ser Tyr Phe Ser Met Ala Lys Val Asn Gin 305 310 315 320 Tyr Glu Asn His Ala Ile Asp Leu Cys Lys Leu Arg Asp Met Trp His 325 330 335 Thr Thr Lys Asn Glu Glu Ala Val Glu Gin Ser Arg Gin Ala Tyr Asp 340 345 350 Asp Tyr Ile Asn Lys Pro Lys Tyr Gly Thr Lys Glu Leu Tyr Thr Ser 355 360 365 Leu Lys Lys Phe Leu Lys Val Ala Leu Pro Thr Asn Leu Ala Lys Glu 370 375 380 Page 2345 of 3790 Ala Glu Glu Lys Ile Ser Lys Gly Thr Tyr Leu Val Lys Pro Arg Asn 385 390 395 400 Ser Glu Asn Gly Val Val Pro Tyr Gin Leu Asn Lys Ile Glu Met Glu 405 410 415 Lys Ile Ile Asp Asn Gin Ser Gin Tyr Tyr Pro Phe Leu Lys Glu Asn 420 425 430 Lys Glu Lys Leu Leu Ser Ile Leu Ser Phe Arg Ile Pro Tyr Tyr Val 435 440 445 Gly Pro Leu Gin Ser Ala Glu Lys Asn Pro Phe Ala Trp Met Glu Arg 450 455 460 Lys Ser Asn Gly His Ala Arg Pro Trp Asn Phe Asp Glu Ile Val Asp 465 470 475 480 Arg Glu Lys Ser Ser Asn Lys Phe Ile Arg Arg Met Thr Val Thr Asp 485 490 495 Ser Tyr Leu Val Gly Glu Pro Val Leu Pro Lys Asn Ser Leu Ile Tyr 500 505 510 Gin Arg Tyr Glu Val Leu Asn Glu Leu Asn Asn Ile Arg Ile Thr Glu 515 520 525 Asn Leu Lys Thr Asn Pro Ile Gly Ser Arg Leu Thr Val Glu Thr Lys 530 535 540 Gin Arg Ile Tyr Asn Glu Leu Phe Lys Lys Tyr Lys Lys Val Thr Val 545 550 555 560 Lys Lys Leu Thr Lys Trp Leu Ile Ala Gin Gly Tyr Tyr Lys Asn Pro 565 570 575 Ile Leu Ile Gly Leu Ser Gin Lys Asp Glu Phe Asn Ser Thr Leu Thr 580 585 590 Thr Tyr Leu Asp Met Lys Lys Ile Phe Gly Ser Ser Phe Met Glu Asp 595 600 605 Asn Lys Asn Tyr Asp Gin Ile Glu Glu Leu Ile Glu Trp Leu Thr Ile 610 615 620 Phe Glu Asp Lys Gin Ile Leu Asn Glu Lys Leu His Ser Ser Lys Tyr 625 630 635 640 Page 2346 of 3790 Ser Tyr Thr Pro Asp Gin Ile Lys Lys Ile Ser Asn Met Arg Tyr Lys 645 650 655 Gly Trp Gly Arg Leu Ser Lys Lys Ile Leu Met Asp Ile Thr Thr Glu 660 665 670 Thr Asn Thr Pro Gin Leu Leu Gin Leu Ser Asn Tyr Ser Ile Leu Asp 675 680 685 Leu Met Trp Ala Thr Asn Asn Asn Phe Ile Ser Ile Met Ser Asn Asp 690 695 700 Lys Tyr Asp Phe Lys Asn Tyr Ile Glu Asn His Asn Leu Asn Lys Asn 705 710 715 720 Glu Asp Gin Asn Ile Ser Asp Leu Val Asn Asp Ile His Val Ser Pro 725 730 735 Ala Leu Lys Arg Gly Ile Thr Gin Ser Ile Lys Ile Val Gin Glu Ile 740 745 750 Val Lys Phe Met Gly His Ala Pro Lys His Ile Phe Ile Glu Val Thr 755 760 765 Arg Glu Thr Lys Lys Ser Glu Ile Thr Thr Ser Arg Glu Lys Arg Ile 770 775 780 Lys Arg Leu Gin Ser Lys Leu Leu Asn Lys Ala Asn Asp Phe Lys Pro 785 790 795 800 Gin Leu Arg Glu Tyr Leu Val Pro Asn Lys Lys Ile Gin Glu Glu Leu 805 810 815 Lys Lys His Lys Asn Asp Leu Ser Ser Glu Arg Ile Met Leu Tyr Phe 820 825 830 Leu Gin Asn Gly Lys Ser Leu Tyr Ser Glu Glu Ser Leu Asn Ile Asn 835 840 845 Lys Leu Ser Asp Tyr Gin Val Asp His Ile Leu Pro Arg Thr Tyr Ile 850 855 860 Pro Asp Asp Ser Leu Glu Asn Lys Ala Leu Val Leu Ala Lys Glu Asn 865 870 875 880 Gin Arg Lys Ala Asp Asp Leu Leu Leu Asn Ser Asn Val Ile Asp Arg 885 895 Page 2347 of 3790 890 Ser Pro Lys Asn Pro Lys Tyr Lys Lys Leu Ile Ala Gin Lys Lys 1115 1120 1125 Page 2348 of 3790 His Ile Glu 1355 Page 2349 of 3790 1027 1313 PRT Lactobacillus fermentum 1027 Page 2350 of 3790 Ile Asp Leu Ser Ser Glu Thr Ser Glu Asp Glu Ile Glu Lys Phe Arg 225 230 235 240 Glu Glu Leu Ser Asp Ala Gin Asn Asp Ile Leu Thr Glu Ile Thr Ser 245 250 255 Leu Phe Ser Gin Ile Met Leu Asn Glu Ile Val Pro Asn Gly Met Ser 260 265 270 Ile Ser Glu Ser Met Met Asp Arg Tyr Trp Thr His Glu Arg Gin Leu 275 280 285 Ala Glu Val Lys Glu Tyr Leu Ala Thr Gin Pro Ala Ser Ala Arg Lys 290 295 300 Glu Phe Asp Gin Val Tyr Asn Lys Tyr Ile Gly Gin Ala Pro Lys Glu 305 310 315 320 Arg Gly Phe Asp Leu Glu Lys Gly Leu Lys Lys Ile Leu Ser Lys Lys 325 330 335 Glu Asn Trp Lys Glu Ile Asp Glu Leu Leu Lys Ala Gly Asp Phe Leu 340 345 350 Pro Lys Gin Arg Thr Ser Ala Asn Gly Val Ile Pro His Gin Met His 355 360 365 Gin Gin Glu Leu Asp Arg Ile Ile Glu Lys Gin Ala Lys Tyr Tyr Pro 370 375 380 Trp Leu Ala Thr Glu Asn Pro Ala Thr Gly Glu Arg Asp Arg His Gin 385 390 395 400 Ala Lys Tyr Glu Leu Asp Gin Leu Val Ser Phe Arg Ile Pro Tyr Tyr 405 410 415 Val Gly Pro Leu Val Thr Pro Glu Val Gin Lys Ala Thr Ser Gly Ala 420 425 430 Lys Phe Ala Trp Ala Lys Arg Lys Glu Asp Gly Glu Ile Thr Pro Trp 435 440 445 Asn Leu Trp Asp Lys Ile Asp Arg Ala Glu Ser Ala Glu Ala Phe Ile 450 455 460 Lys Arg Met Thr Val Lys Asp Thr Tyr Leu Leu Asn Glu Asp Val Leu 465 470 475 480 Page 2351 of 3790 Pro Ala Asn Ser Leu Leu Tyr Gin Lys Tyr Asn Val Leu Asn Glu Leu 485 490 495 Asn Asn Val Arg Val Asn Gly Arg Arg Leu Ser Val Gly Ile Lys Gin 500 505 510 Asp Ile Tyr Thr Glu Leu Phe Lys Lys Lys Lys Thr Val Lys Val Ser 515 520 525 Asp Val Ala Ser Leu Val Met Ala Lys Thr Arg Gly Val Asn Lys Pro 530 535 540 Ser Val Glu Gly Leu Ser Asp Pro Lys Lys Phe Asn Ser Asn Leu Ala 545 550 555 560 Thr Tyr Leu Asp Leu Lys Ser Ile Val Gly Asp Lys Val Asp Asp Asn 565 570 575 Arg Tyr Gin Thr Asp Leu Glu Asn Ile Ile Glu Trp Arg Ser Val Phe 580 585 590 Glu Asp Gly Glu Ile Phe Ala Asp Lys Leu Thr Glu Val Glu Trp Leu 595 600 605 Thr Asp Gin Gin Arg Ser Ala Leu Val Lys Lys Arg Tyr Lys Gly Trp 610 615 620 Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Ile Val Asp Glu Asn Gly 625 630 635 640 Gin Arg Ile Ile Asp Leu Met Trp Asn Thr Asp Gin Asn Phe Met Gin 645 650 655 Ile Val Asn Gin Pro Val Phe Lys Glu Gin Ile Asp Gin Leu Asn Gin 660 665 670 Lys Ala Ile Thr Asn Asp Gly Met Thr Leu Arg Glu Trp Val Glu Ser 675 680 685 Val Leu Asp Gly Ala Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Trp 690 695 700 Gin Val Val Arg Val Val Glu Asp Ile Val Lys Ala Val Gly Asn Ala 705 710 715 720 Pro Lys Ser Ile Ser Ile Glu Phe Ala Arg Asn Glu Gly Asn Lys Gly Ser Asp Leu Page 2353 of 3790 Lys Leu Arg Asn Phe Asn Phe Phe His Glu Leu Met Glu 980 985 990 Gly Asp Lys 995 Ser Gin Gly Lys Val 1000 Ala Gly Pro Leu Leu Glu Asp Ala Asp Gin Val Asp Gin Gin Thr Gly Glu Leu Ser Ile Ile Page 2354 of 3790 1310 1028 1327 PRT Lactobacillus florum Page 2355 of 3790 Asp Asp Pro Gin Phe Asp Asp Gin Lys Phe His Gin Gin Tyr Pro Thr 115 120 125 Ile Tyr His Leu Arg Ser Ala Leu Ala Gin Pro Asp Ala Pro Gin Ala 130 135 140 Asp Val Arg Leu Ile Tyr Leu Ala Leu His His Met Ile Lys Phe Arg 145 150 155 160 Gly His Phe Leu Asn Gly Ala Ala Val Glu Lys Phe His Gly Gly Gin 165 170 175 Leu His Leu Glu Ser Glu Phe Gin Glu Leu Asn Gin Ile Phe Ser Asn 180 185 190 Gin Gin Arg Asp His Val Gin Leu Gin Thr Ser Ser Leu Asp Glu Val 195 200 205 Ala Thr Ile Leu Lys Asp Asn Gin Arg Thr Pro Ser Asp Arg Gin Arg 210 215 220 Glu Leu Ser Ala Arg Leu Phe Val Pro Val Asp Lys Thr Ile Asp Lys 225 230 235 240 Glu Asn Lys Lys Leu Ala Thr Glu Leu Leu Lys Ala Val Leu Gly Leu 245 250 255 Lys Ala Lys Phe Asp Val Ile Leu Gly Val Glu Ala Thr Asp Pro Gin 260 265 270 Ala Phe Lys Leu Gin Phe Ser Ser Asp Asp Phe Asp Asp Lys Ile Ala 275 280 285 Glu Leu Ala Ser Glu Leu Thr Asp Glu Ala Asn Glu Ile Leu Thr Val 290 295 300 Leu Gin Arg Leu Tyr Phe Ser Leu Asn Leu Ala Asp Ile Leu Thr Asn 305 310 315 320 Arg Gin Thr Lys Gin Val Ala Asp Ser Ile Ser Thr Ala Met Ile Asn 325 330 335 Arg Tyr Asp Asp His Lys His His Leu Lys Met Leu Lys Glu Leu Glu 340 345 350 Ala Gin Val Thr Gin Glu Gin Arg Asp Gly Leu Lys Lys Ala Tyr Asp 355 360 365 Page 2356 of 3790 Glu Tyr Ile Asp Gly Asp Lys Pro Thr Ile Asp Thr Phe Tyr Thr Asn 370 375 380 Ile Lys Lys Asn Leu Asp Asp Ser Glu Leu Ala Asn Gin Ile Lys Ser 385 390 395 400 Leu Ile Asp Leu Gin Ala Phe Met Pro Lys Gin Arg Ser Lys Glu Asn 405 410 415 Gly Ser Ile Pro His Gin Leu His Gin Arg Glu Leu Asp Gin Leu Ile 420 425 430 Glu Val Gin Gly Lys Tyr Tyr Pro Trp Leu Leu Ala Ala Lys Asp Lys 435 440 445 Leu Asp Ala Leu Ile Ala Phe Arg Val Pro Tyr Tyr Val Gly Pro Met 450 455 460 Ile Asp Pro Asn Gin Ser Asp Asp Pro Gin Asn Thr Lys Phe Ala Trp 465 470 475 480 Met Val Arg Lys Glu Ala Gly Glu Ile Thr Pro Trp Asn Phe Glu Glu 485 490 495 Lys Val Asp Lys Thr Ser Ser Ala Thr Asn Phe Ile Lys Arg Met Thr 500 505 510 Thr Thr Asp Thr Tyr Leu Leu Gly Glu Pro Val Leu Pro Lys Asn Ser 515 520 525 Leu Leu Tyr Gin Gin Phe Thr Val Leu Asn Glu Leu Asn Lys Leu Lys 530 535 540 Val Asn Gly Lys Ala Leu Thr Val Asp Gin Lys Lys Tyr Leu Tyr Glu 545 550 555 560 His Val Cys Lys Lys Gin Arg Arg Val Thr Leu Lys Lys Leu Ser Asp 565 570 575 Cys Leu Met Ala Arg Gly Asp Phe Pro Met Gly Ala Ile Phe Thr Gly 580 585 590 Thr Thr Asp Gin Lys Asn Met Asn Asn Thr Leu Lys Thr Tyr Gin Asp 595 600 605 Phe Gin Glu Ile Phe Gly Asp Glu Ile Asp Asn Pro Asp Arg Gin Val Page 2358 of 3790 Asn Arg Pro Ser Asp Ile Tyr Gly Gly Tyr Ser Asn Glu Asn Gly 1100 1105 1110 Page 2359 of 3790 Val Ser Asp Leu 1325 1029 1386 Page 2360 of 3790 PRT Lactobacillus hominis Page 2361 of 3790 Met Lys Asp Val Ser Lys Gin Ile Val Asn Ala Ile Leu Gly Tyr Lys 245 250 255 Thr Lys Phe Glu Thr Ile Leu Leu Lys Asp Val Ser Lys Asp Glu Ala 260 265 270 Asp Asp Trp Glu Phe Lys Leu Thr Asp Val Asp Ala Asp Asn Lys Phe 275 280 285 Glu Asn Leu Ile Gly Asp Leu Asn Glu Asn Glu Gin Glu Ile Leu Leu 290 295 300 Val Ile Arg Lys Leu Ala Asn Ala Ile Thr Leu Ser Asn Ile Val Glu 305 310 315 320 Glu Gly Lys Thr Leu Ser Glu Ser Met Lys Asp Lys Tyr Lys Lys His 325 330 335 Ser Asp Asp Leu Lys Leu Leu Lys Gin Val Ile Ser Asp His Pro Asp 340 345 350 Arg Asp Lys Ala Lys Lys Leu Ala Leu Ala Tyr Asp Leu Tyr Val Asn 355 360 365 Asn Arg His Gly Lys Ile Leu Gin Ala Lys Asp Ile Leu Glu Lys Lys 370 375 380 Lys Thr Leu Ser Lys Glu Asp Phe Tyr Lys Glu Ile Lys Lys Asn Leu 385 390 395 400 Asp Asp Ser Lys Glu Ser Gin Glu Ile Leu Asp Ala Ile Ser Leu Asp 405 410 415 Ser Phe Met Pro Lys Gin Arg Thr Asn Glu Asn Gly Val Ile Pro Tyr 420 425 430 Gin Leu His Gin Leu Glu Leu Asp Lys Ile Ile Glu Asn Gin Gly Lys 435 440 445 Tyr Tyr Pro Phe Leu Lys Glu Val Asn Pro Val Ser Ser His Leu Lys 450 455 460 Gin Ala Pro Tyr Lys Leu Asp Glu Leu Ile Arg Phe Arg Val Pro Tyr 465 470 475 480 Tyr Val Gly Pro Leu Ile Ser Pro Asn Glu Ser Thr Lys Asn Lys Gin Page 2363 of 3790 Ile Ala Val Ala Asn Gin Asn Leu Leu Val Asp Thr Ser Val Glu Asp 740 745 750 Ile Leu Asn Glu Ala Tyr Thr Ser Pro Ala Asn Lys Lys Ala Ile Arg 755 760 765 Gin Val Val Lys Val Val Asp Asp Ile Val Lys Ala Thr Ser Gly Lys 770 775 780 Val Pro Lys Gin Ile Ala Ile Glu Phe Thr Arg Asp Ala Asp Asp Asn 785 790 795 800 Ala Lys Ile Ser Gin Ser Arg Ala Asn Lys Leu Arg Lys Val Tyr Lys 805 810 815 Glu Met Ser Asn Glu Leu Ala Ser Glu Thr Ile Arg Asn Glu Leu Glu 820 825 830 Arg Val Ala Lys Asp Gin Lys Leu Leu Lys Asp Lys His Tyr Leu Tyr 835 840 845 Phe Met Gin Leu Gly Arg Asp Ala Tyr Thr Gly Glu Leu Ile Asp Ile 850 855 860 Asp Asn Leu Glu Gin Tyr Asp Ile Asp His Val Leu Pro Gin Ser Phe 865 870 875 880 Ile Lys Asp Asp Ser Leu Glu Asn Arg Val Leu Val Lys Lys Ala Val 885 890 895 Asn Asn Gly Lys Ser Asp Asn Val Pro Val Lys Leu Tyr Gly Asn Arg 900 905 910 Met Ala Thr Asp Leu Gly Met Thr Ile Arg His Met Trp Glu Lys Trp 915 920 925 Lys Glu Gin Gly Leu Ile Thr Lys Thr Lys Tyr Asn Asn Leu Ile Ile 930 935 940 Asp Pro Asp Lys Ile Asn Lys Tyr Glu Ser Ser Gly Phe Ile His Arg 945 950 955 960 Gin Leu Val Glu Thr Ser Gin Ile Ile Lys Leu Val Ser Thr Ile Leu 965 970 975 Gin Ser Lys Tyr Pro Asp Thr Glu Ile Ile Val Val Lys Ala Arg Tyr 980 985 990 Page 2364 of 3790 Asn His Tyr Leu Arg Lys Arg Leu Asn Leu Tyr Lys Ser Arg Glu Val 995 1000 1005 Page 2365 of 3790 Ser Asp Leu 1385 1030 270 PRT Lactobacillus iners Page 2366 of 3790 Lys Gly Ile Ile Lys Leu Leu Ser Gly Gly Lys Gin Asp Leu Ser Asn 50 55 60 Met Phe Arg Asp Glu Thr Leu Lys Asn Ser Asn Tyr Lys Asn Leu Lys 65 70 75 80 Phe Ser Asp Asn Arg Phe Asp Asp Glu Arg Asp Gly Tyr Ala Ala Asp 85 90 95 Leu Gly Asp Arg Ile Asp Leu Leu Ile Leu Leu Lys Gin Ile Tyr Asp 100 105 110 Ala Ser Ile Leu Glu Ser Met Met Ser Gin Ala Arg Val Ser Ile Asp 115 120 125 Gly His Lys Tyr Ile Ser Ser Ala Lys Val Cys Ala Tyr Glu Lys His 130 135 140 Lys Ser Asp Leu Lys Arg Leu Lys Ser Leu Ile Lys Lys Tyr Leu Pro 145 150 155 160 Ser Glu Tyr Asn Asn Ile Phe Arg Lys Ile Thr Glu Lys Asp Asn Tyr 165 170 175 Val Ala Tyr Ser Lys Ser Asn Ile Thr Asn Asn Lys Arg Glu Lys Ala 180 185 190 Leu Lys Tyr Val Lys Tyr Val Asp Phe Thr Lys Tyr Leu Thr Lys Lys 195 200 205 Leu Lys Thr Ile Lys Thr Gin Asp Ala Glu Asp Asp Gin Glu Ile Phe 210 215 220 Glu Ile Lys Gly Glu Leu Glu Lys Gin Ser Phe Leu Pro Lys Gin Arg 225 230 235 240 Thr Leu Asp Asn Ser Ile Ile Pro Tyr Gin Leu His Leu Met Glu Leu 245 250 255 Lys Lys Tyr Leu Ile Ile Asn Leu Asn Ile Met Thr Phe Cys 260 265 270 1031 255 PRT Lactobacillus iners Page 2367 of 3790 Thr Leu Asp Asn Ser Ile Ile Pro Tyr Gin Leu His Leu Met Glu Asp Ser Asp Leu Phe Thr Glu Asp Glu Leu Asn Lys Ile Val Lys Leu 210 215 Page 2369 of 3790 220 340 1033 447 PRT Lactobacillus iners 1033 Ile Asn Asp Leu His His Ala Gin Asp Ala Tyr Leu Asn Ile Val Val Page 2371 of 3790 Page 2372 of 3790 Gly Lys Asp Lys Tyr Gin Asp Leu Ser Asn Glu Leu Asp Asn Lys Asp 115 120 125 Asp Arg Asp Leu Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gin Leu 130 135 140 Gly Arg Ser Met Tyr Ser Leu Lys Pro Ile Asp Ile Ser Glu Leu Met 145 150 155 160 Asn Lys Asn Leu Tyr Asp Gin Asp His Ile Phe Pro Lys Ser Lys Lys 165 170 175 Tyr Asp Asp Ser Ile Glu Asn Arg Val Leu Val Glu Lys Glu Leu Asn 180 185 190 Val Lys Lys Ser Asp Ile Tyr Pro Ile Ser Asp Ala Asn Ile Ile Pro 195 200 205 Gin Lys Ile Lys Gly Gin Val Glu Ser Phe Trp Lys Met Leu Tyr Asp 210 215 220 His Lys Leu Ile Gly Asp Lys Lys Tyr Ala Arg Leu Ile Arg Ser Lys 225 230 235 240 Ala Phe Thr Asp Asp Glu Leu Ala Gly Phe Ile Ala Arg Gin Leu Val 245 250 255 Glu Thr Arg Gin Ala Thr Lys Glu Thr Ala Asp Leu Leu Lys Arg Leu 260 265 270 Cys Pro Lys Ser Arg Ile Val Tyr Ala Lys Ala Gin Asn Ala Ser Ile 275 280 285 Phe Arg Gin Lys Phe Asp Ile Pro Lys Ser Arg Thr Ile Asn Asp Leu 290 295 300 His His Ala Gin Asp Ala Tyr Leu Asn Ile Val Val Gly Asn Ile Phe 305 310 315 320 Asp Thr Lys Phe Thr Gin Asp Pro Arg Asn Phe Ile Lys Asn Thr Lys 325 330 335 Asp Ser Arg Asn Tyr Asn Leu Glu Lys Ile Tyr Asp Tyr Asn Val Glu 340 345 350 Arg Asn Asn Tyr Val Ala Trp Ile Ala Pro Asp Gly Glu Thr Asn Gly 355 360 365 Page 2373 of 3790 Thr Ile Ala Asn Val Lys Cys Asn Leu Ser Thr Lys Asp Phe Arg Val 370 375 380 Thr Arg Pro Ser Phe Tyr Lys Lys Gly Ala Leu Phe Asn Gin Asn Leu 385 390 395 400 Ser Arg Lys Gly Ser Asn Leu Ala Pro Ile Lys Glu His Ser Pro Lys 405 410 415 Ser Asn Pro Leu Lys Tyr Gly Gly Tyr Ser Gly Lys Asn Asn Ser Phe 420 425 430 Phe Val Val Val Ala Gly Lys Asp Asn Lys Gly Lys Asp Ile Val Lys 435 440 445 Leu Ile Pro Val Asn Thr Leu Ile Tyr Asn Lys Met Leu His Cys Asp 450 455 460 Tyr Lys Ala Lys Gin Glu Leu Leu Thr Ser Tyr Val Ala Asn Asn Phe 465 470 475 480 Ala Ile Asn Asn Phe Arg Ile Val Lys Asp Asp Ile Lys Met Tyr Ser 485 490 495 Leu Val Lys Ile Asp Gly Ala Tyr Tyr Tyr Leu Val Gly Gly Thr Asp 500 505 510 Glu Arg Ile Glu Val Lys Asn Ala Met Gin Leu Leu Leu Ser Lys Asp 515 520 525 Ser Ile Lys Ala Val Lys Ile Leu Glu Lys Glu Ser Lys Asp Gin Phe 530 535 540 Ala Asn Ile Lys Asn Tyr Lys Asp Ile Asp Ile Lys Leu Gly Arg Thr 545 550 555 560 Phe Asn Glu Val Val Ser Lys Tyr Thr Asn Ser Val Phe Gly Lys Ser 565 570 575 Met Leu Ile Ser Asp Lys Tyr Arg Lys Asp Ile Phe Lys Ser Val Glu 580 585 590 Lys Ser Ile Leu Glu Phe Asn His Leu Asp Thr Ile Gly Lys Ala Asp 595 600 605 Asn Leu Leu Lys Phe Val Thr Leu Met Arg Pro Ser Gly Ser Ala His 610 615 620 Page 2374 of 3790 Page 2375 of 3790 Gly Glu Asp Gly Ile Gly Pro Val Asp Lys Leu Asn Asp Leu Leu Lys 180 185 190 Glu Ile Tyr Ser Glu Tyr Ser Pro Glu Leu Ala Thr Asn Asn Leu Ser 195 200 205 Lys Ile Glu Asp Ile Ile Lys Asp Lys Asn Leu Tyr Lys Gin Asp Lys 210 215 220 Leu Lys Gin Val Ala Thr Leu Leu Ile Lys Glu Ala Asp Ser Lys Asp 225 230 235 240 Lys Ala Lys Leu Asn Lys Asp Ile Ala Lys Gin Val Ala Asn Ser Phe 245 250 255 Met Gly Tyr Met Phe Arg Leu Asp Thr Leu Phe Ser Leu Thr Asp Val 260 265 270 Asp Val Lys Asp Tyr Lys Leu Lys Phe Ser Asp Ala Asn Ile Asp Glu 275 280 285 Ser Leu Asp Asp Leu Thr Ser Leu Leu Thr Asp Ala Gin Ile Glu Phe 290 295 300 Val Leu Glu Leu Gin Ser Ile Tyr Asn Thr Ile Val Leu Asn Glu Ile 305 310 315 320 Val Pro Asp Gly Met Ser Leu Ser Glu Ser Met Ile Lys Lys Tyr Asp 325 330 335 Asp His Lys Glu Asp Leu Lys Ile Phe Lys Glu Tyr Ile Asp Ser Leu 340 345 350 Ser Asp Gin Lys Lys Ala Lys Lys Leu Leu Ser Ala Tyr Asn Leu Tyr 355 360 365 Val Asn Tyr Arg Lys Ser Asp Leu Val Glu Ala Lys Asn Leu Phe Lys 370 375 380 Asn Lys Lys Val Gly Asp Lys Asn Phe Ala Asp Val Ile Ser Asn Phe 385 390 395 400 Glu Val Phe Gly Lys Phe Val Ser Asp Asn Leu Asp Asp Ser Glu Leu 405 410 415 Ala Asn Lys Ile Lys Ala Arg Leu Asp Leu Gly Glu Phe Leu Pro Lys Page 2377 of 3790 Phe Lys Arg Lys Leu Lys Glu Ile Thr Trp Leu Thr Ser Glu Gin Ile 675 680 685 Lys Gin Val Ser Ser Lys Arg Tyr Ser Gly Trp Gly Arg Leu Ser Lys 690 695 700 Lys Leu Leu Thr Gin Ile Thr Asp Glu Asn Gly Val Asn Ile Leu Gin 705 710 715 720 Arg Leu Trp Asn Glu Pro Glu Thr Leu Thr Glu Val Leu Ala Asn Pro 725 730 735 Val Ile Lys Arg Lys Ile Val Glu Ala Asn Ser Ser Phe Thr Lys Ala 740 745 750 Lys Asp Met Lys Asp Ile Leu Val Glu Ala Tyr Thr Ser Pro Gin Asn 755 760 765 Lys Lys Ala Ile Arg Gin Val Met Arg Val Val Asp Asp Ile Ile Ala 770 775 780 Ala Ala His Gly Lys Lys Pro Ser Gin Ile Ala Ile Glu Phe Ala Arg 785 790 795 800 Glu Asp Gin Asp Asn Pro Gin Met Thr Lys Ser Arg Lys Ala Gin Leu 805 810 815 Asp Gin Ile Tyr Ala Lys Ile Ser Asp Glu Phe Leu Asp Asp Ala Val 820 825 830 Lys Asn Glu Leu Lys Asn Met Lys Asp Asn Lys Pro Leu Ala Lys Asp 835 840 845 Lys Val Phe Leu Tyr Phe Lys Gin Met Gly Arg Asp Ala Tyr Ser Gly 850 855 860 Glu Lys Leu Ser Leu Asp Asn Leu Gin Asp Tyr Asp Ile Asp His Ile 865 870 875 880 Tyr Pro Gin Ser Phe Ile Lys Asp Asp Ser Phe Asp Asn Arg Val Leu 885 890 895 Val Gin Arg Ala Tyr Asn Asn Gly Lys Ser Asp Asn Val Pro Val Leu 900 905 910 Leu Phe Gly Asn Lys Ile Ala Ala Gly Leu Gly Ile Thr Ile Arg Gin 915 920 925 Page 2378 of 3790 Page 2379 of 3790 1036 Page 2380 of 3790 1382 PRT Lactobacillus mucosae Arg Arg Arg Leu Ser Arg Arg Arg Trp Arg Leu Gin Phe Leu Asp Glu 50 55 60 Phe Phe Ala Pro Tyr Leu Ala Glu Val Asp Pro Asn Phe Leu Ala Arg 65 70 75 80 Lys Gin Lys Lys Leu Asp Arg Gin Lys Ala Val Ala Lys Leu Leu Pro Page 2382 of 3790 Ala Asp Gin Gin Lys Thr Ser Lys Ala Ser Phe Ala Trp Ala Val Arg 485 490 495 Lys Lys Ala Gly Lys Ile Thr Pro Trp Asn Phe Tyr Asp Met Ile Asp 500 505 510 Arg Glu Lys Ser Ala Asn Asn Phe Ile Lys Arg Met Thr Asn Lys Asp 515 520 525 Thr Tyr Leu Leu Ser Glu Asp Val Leu Pro Ala Ser Ser Leu Leu Tyr 530 535 540 Gin Lys Phe Thr Val Leu Asn Glu Leu Asn Asn Ile Arg Val Asn Gly 545 550 555 560 Arg Lys Leu Gin Pro Ala Leu Lys Gin Ala Ile Tyr Thr Asp Leu Phe 565 570 575 Gin Lys Arg Lys Thr Val Asn Leu Lys Thr Leu Thr Asn Phe Leu Ala 580 585 590 Ile His Glu Pro Thr Leu Thr Lys Pro Lys Ile Glu Gly Leu Ser Asn 595 600 605 Gly Arg Ser Phe Asn Ser Ser Leu Gly Thr Tyr Ile Asp Met Ser Lys 610 615 620 Ile Leu Gly Asp Ser Leu Asp Asp Leu Asn Tyr Arg Asp Asp Ile Glu 625 630 635 640 Lys Ile Ile Glu Trp Ser Thr Val Phe Glu Asp Ser Glu Ile Tyr Gly 645 650 655 Val Lys Leu Gin Glu Ile Gin Trp Leu Thr Asn Glu Gin Arg Glu Lys 660 665 670 Leu Val Arg Lys Arg Tyr Gin Gly Trp Gly Arg Leu Ser Lys Lys Leu 675 680 685 Leu Thr Gly Ile Thr Asp Glu Asn Gly Gin Arg Ile Ile Asp Leu Met 690 695 700 Trp Asp Thr Ser Lys Asn Phe Met Gin Ile Val His Gin Pro Val Phe 705 710 715 720 Glu Glu Gin Ile Ala Glu Leu Asn Gin Gin Leu Leu Gin Asp Ala Asp 725 730 735 Page 2383 of 3790 Lys Ala Pro Leu Glu Val Val Asp Asp Ile Leu Ala Asp Ala Tyr Thr 740 745 750 Ser Pro Gin Asn Lys Lys Ala Ile Arg Gin Val Val Lys Val Val Ala 755 760 765 Asp Val Val Lys Ala Val Gly Asn Ala Pro Ala Ser Ile Ser Ile Glu 770 775 780 Phe Ala Arg Asn Glu Asp Arg Asn Lys Glu Leu Lys Asn Ser Arg Arg 785 790 795 800 His Ser Ile Glu Lys Leu Tyr His Glu Thr Ala Glu Lys Leu Val Lys 805 810 815 Gin Thr Asn Leu Leu Glu Glu Leu Gly Asn Val Lys Asp Leu Asn Asp 820 825 830 Arg Tyr Tyr Leu Tyr Phe Thr Gin Ala Gly Arg Asp Met Tyr Asp Gly 835 840 845 Thr Pro Ile Asn Ile Asp Glu Ile Ser Thr His Tyr Glu Ile Asp His 850 855 860 Ile Leu Pro Gin Ser Phe Leu Lys Asp Asn Ser Leu Asp Asn Arg Val 865 870 875 880 Leu Val Lys Lys Ser Glu Asn Ala Ala Lys Ser Asp Arg Val Pro Ala 885 890 895 Lys Leu Tyr Gly Ala Lys Met Arg Ala Phe Trp Lys Gin Leu Lys Glu 900 905 910 Ser Gin Leu Ile Ser Asn Arg Lys Tyr Leu Asn Leu Thr Thr Asp Pro 915 920 925 Glu Gin Val Asp Lys Tyr Gin Met Gin Gly Phe Val His Arg Gin Leu 930 935 940 Val Glu Thr Arg Gin Ile Ile Lys Leu Ala Ala Asn Ile Phe Gly Ser 945 950 955 960 Leu Tyr Pro Asp Ser Ala Val Ile Glu Thr Arg Ala Glu Leu Thr Lys 965 970 975 Gin Leu Arg Glu Lys Phe Ser Leu Tyr Lys Val Arg Asp Val Asn Asp 980 985 990 Page 2384 of 3790 Tyr His His Ala Val Asp Ala Tyr Leu Thr Ala Phe Ala Gly His Tyr 995 1000 1005 Gly Asp Thr Lys Phe Thr Leu Gly Ser Ala Thr Tyr Gin His Asn 1037 1382 PRT Lactobacillus pentosus Ala Glu Ser Thr Arg Ile Phe Arg Gly Thr Arg Arg Arg Leu Ser His Page 2386 of 3790 55 60 Arg His Trp Arg Leu Gly Tyr Leu Asp Arg Ile Phe Asp Asn Glu Ile 65 70 75 80 Ala Lys Val Asp Glu Asn Phe Leu Pro Arg Leu Lys Ala Ser Lys Arg 85 90 95 Ala Arg Ser Asp Glu Lys Arg Ser Phe Arg Gly Ser Leu Leu Phe Pro 100 105 110 Glu Thr Gly Asp Asp Ala Tyr Tyr Gin Lys Tyr Pro Thr Ile Tyr His 115 120 125 Leu Arg Tyr Ala Leu Ile Thr Gin Lys Lys Gin Phe Asp Ile Arg Leu 130 135 140 Ile Tyr Leu Ala Leu His His Met Ile Lys Tyr Arg Gly Asn Phe Leu 145 150 155 160 Asp Thr Thr Pro Val Ser Ala Phe Asn Ile His Asp Ile Asp Leu Thr 165 170 175 Asp Gin Phe Ala Ser Leu Asn Asp Cys Tyr Gin Leu Leu Asp Met Asp 180 185 190 Phe Glu Phe Gin Phe Asp Leu Asn Asn Ile Glu Gin Val Gin Lys Leu 195 200 205 Leu Leu Asp Glu Thr Leu Ser Lys Thr Lys Arg Gin Ala Ala Val Ser 210 215 220 Lys Val Leu Val Met Ser Thr Gly Asn Lys Ala Phe Asp Asp Gin Gin 225 230 235 240 Asn Gly Ile Ala Ser Glu Phe Ile Lys Ala Leu Leu Gly Gly Pro Phe 245 250 255 Asp Leu Ser Lys Ile Leu Asn Leu Ser Val Ala Asp Val Lys Ser Trp 260 265 270 Lys Leu His Met Thr Asp Lys Asp Val Asp Asp Thr Leu Asn Ser Leu 275 280 285 Val Glu Glu Leu Asp Glu Asn His Lys Gin Ile Val Asn Leu Leu Gin 290 295 300 Page 2387 of 3790 Met Ile Tyr Ser Gin Val Met Met Leu Gly Leu Leu Asn Gly Gin Gin 305 310 315 320 Ser Ile Ser Ala Ser Met Ile Glu Arg Tyr Asp Asp His Ala Lys His 325 330 335 Trp Ala Ala Leu Lys Lys Leu Leu Pro Ala Leu Gly Glu Gin Glu Gin 340 345 350 Ser Thr Ile Ile His Ala Tyr Thr Ala Tyr Thr Gly His Ser Arg Thr 355 360 365 Lys Gin Leu Ser Arg Ala Glu Phe Tyr Thr Lys Val Asn Ser Ile Leu 370 375 380 Lys Lys His Glu Asn Ile Ala Glu Ala Thr Gly Leu Ile Glu Leu Ile 385 390 395 400 Asp Arg Asn Glu Phe Met Pro Lys Gin Arg Asp Ala Val Asn Gly Val 405 410 415 Ile Pro His Gin Leu His Gin Arg Glu Leu Gin Leu Ile Ile Gin Asn 420 425 430 Gin Gin Lys Tyr Tyr Pro Phe Leu Ala Ala Lys Ala Tyr Pro Asp Ala 435 440 445 Asp Glu Thr Met Ile Glu Gin Leu Leu Ser Phe Arg Val Pro Tyr Tyr 450 455 460 Ala Gly Pro Leu Val Asp Arg Asp Phe Ile Asn Glu Ser Ser Asp Gin 465 470 475 480 Glu Gin Ala Met Gin Asn Thr Lys Phe Ser Trp Leu Lys Arg Arg Glu 485 490 495 Ala Gly Glu Ile Thr Pro Trp Asn Phe Glu Gin Lys Val Asp Val Gin 500 505 510 Glu Thr Ala Asn Arg Phe Ile Lys Arg Leu Thr Thr Lys Asp Thr Tyr 515 520 525 Leu Met Thr Glu Asp Val Leu Pro Lys Glu Ser Leu Ile Tyr Gin Arg 530 535 540 Phe Glu Val Leu Asn Glu Leu Asn Ala Ile Arg Ile Asn Asp Arg Arg 545 550 555 560 Page 2388 of 3790 Leu Thr Ala Glu Asn Lys Gin Leu Ala Phe Gin Gin Leu Phe Met Ala 565 570 575 Gly Asn Thr Lys Asn Val Ser Ile Lys Lys Phe Arg Asn Phe Val Phe 580 585 590 Asp Ser Leu Lys Phe Pro Glu Lys Val Lys Ile Thr Gly Phe Ala Gly 595 600 605 Gin His Asn Phe Leu Ala Lys Leu Ser Thr Tyr His Asp Phe Lys Lys 610 615 620 Ile Phe Gly Glu Arg Val Asp His Thr Asp Leu Gin Pro Asp Phe Glu 625 630 635 640 Arg Ile Val Glu Trp Cys Thr Ile Phe Glu Asp Arg His Ile Tyr Arg 645 650 655 Glu Lys Leu Lys Glu Ile Gin Trp Leu Ser Gin Ser Glu Ile Asp Gin 660 665 670 Leu Val Leu Ile Arg Asn His Gly Trp Gly Arg Leu Ser Lys Arg Leu 675 680 685 Leu Thr Gly Ile Arg Asp Ser Asp Gly Arg Thr Val Met Asp Gin Leu 690 695 700 Trp Phe Gly Thr Asp Asn Phe Met Arg Ile Ile Ser Gin Ser Asp Phe 705 710 715 720 Ala Ala Ala Ile Ala Asn Glu Asn Arg Thr Gin Leu Asn Gin His Gly 725 730 735 Leu Glu Asp Val Leu Asp Ser Ala Phe Met Ser Pro Gin Asn Lys Lys 740 745 750 Ala Ile Arg Gin Val Leu Lys Val Val Asp Asp Ile Glu Gin Thr Leu 755 760 765 Gly Cys Pro Pro Lys Lys Val Met Ile Glu Phe Thr Arg Ser Pro Asp 770 775 780 Lys Lys Lys Gin Arg Thr Val Thr Arg Leu Glu Lys Val Gin Gin Ala 785 790 795 800 Tyr Lys Ala Val Ala Asp Gin Leu Ala Gly Gin Ser Ile Val Ser Glu 805 810 815 Page 2389 of 3790 Ile Glu Thr Gly Gin Thr Leu Trp Asp Asp Gin Ile Arg Gin Gin 1038 1361 PRT Lactobacillus pentosus Page 2392 of 3790 Asp Lys Leu Met Thr Ser Asn Arg Lys Phe Asp Ile Arg Glu Ile Tyr 130 135 140 Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Arg Thr 145 150 155 160 Gly Pro Ala Ser Gin Tyr Gly Ser Ala Ser Leu His Leu Ala Thr Ser 165 170 175 Phe Gin Lys Leu Asn Asp Leu Phe Ala Gin Ser Glu Glu Thr Leu Asn 180 185 190 Leu Lys Leu Val Thr Asp Glu Ala Leu Leu Gin Gin Ile Gin Gin Ile 195 200 205 Leu Val Arg Thr Asp Leu Ser Arg Ser Glu Gin Gin Arg Gin Ile Trp 210 215 220 Pro Leu Met Ala Val Leu Thr Gly Ala Ser Ala Ala Glu Lys Lys Arg 225 230 235 240 Gin Lys Asn Val Val Val Glu Leu Ser Lys Ala Leu Val Gly Leu Lys 245 250 255 Ala Lys Met Asn Val Val Thr Leu Thr Glu Val Asp Ala Ala Val Val 260 265 270 Lys Asp Trp Thr Phe Thr Met Glu Glu Ser Gin Asp Lys Leu Pro Glu 275 280 285 Ile Glu Glu Gin Leu Ser Glu Val Gly Gin Gin Ile Met Asp Glu Val 290 295 300 Ile Gin Leu Tyr Ala Ser Val Asn Leu Ala Gin Leu Ile Pro Ala Gly 305 310 315 320 Lys Arg Phe Ser Gin His Met Val Glu Lys Tyr Lys His His Glu Lys 325 330 335 Asn Leu Glu Leu Leu Lys Ala Tyr Ile His Ser Gin Ser Asp Ser Lys 340 345 350 Arg Gly Arg Glu Ile Arg Ala Thr Tyr Asp Arg Tyr Ile Asp Gly Val 355 360 365 Asp Ser Lys Pro Val Thr Gin Glu Met Phe Tyr Lys Asp Leu Met Lys 370 375 380 Page 2393 of 3790 Tyr Val Glu Ala Asp Ala Thr Ser Asn His Leu Ala Ala Glu Ile Lys 385 390 395 400 Asp Glu Ile Asp Ser Glu Gin Phe Met Pro Lys Leu Arg Thr Lys Gin 405 410 415 Asn Gly Ser Ile Pro Tyr Gin Val Gin Gin Tyr Glu Leu Asp Gin Ile 420 425 430 Ile Ser His Gin Lys Lys Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 435 440 445 Val Ala Glu Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Val 450 455 460 Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Asp 465 470 475 480 Gin Gin Ala Thr Ser Gly Ala Gly Phe Ala Trp Met Val Arg Lys Ala 485 490 495 Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Gin Lys Val Asp Arg Ile 500 505 510 Ala Ser Ala Thr Ala Phe Ile Gin Arg Met Gin Thr Thr Asp Thr Tyr 515 520 525 Leu Ile Gly Glu Asp Val Leu Pro Ala Arg Ser Leu Ile Tyr Gin Arg 530 535 540 Phe Met Val Leu Asn Glu Leu Asn Asn Met Arg Val Glu Asp Arg Lys 545 550 555 560 Leu Ala Pro Gin Gin Lys Gin Arg Leu Tyr Asn Gin Val Phe Lys Gin 565 570 575 His Gin His Val Ser Val Lys Asn Ile Gin Gin Asn Leu Met Asp Ala 580 585 590 Gly Glu Tyr Arg Lys Thr Pro Gin Ile Thr Gly Leu Ala Asp Pro Lys 595 600 605 Gly Phe Asn Ser Ser Leu Ser Thr Tyr His Asp Phe Lys Lys Ile Leu 610 615 620 Leu Glu Ala Ile Ala Asp Glu His Lys Arg Ala Asp Ile Glu Lys Ile 625 630 635 640 Page 2394 of 3790 Ile Leu Trp Ser Thr Thr Phe Glu Asp Ser Ala Ile Phe Lys Gin Lys 645 650 655 Leu Glu Glu Val Ala Trp Leu Thr Asp Ala Gin Arg Lys Gin Leu Ser 660 665 670 Gly Leu Arg Tyr Arg Gly Trp Gly Gin Leu Ser His Lys Leu Leu Thr 675 680 685 Ala Phe Lys Asp Asp Lys Gly Arg Ser Ile Met Asp Gly Leu Trp Glu 690 695 700 Thr Ser Asp Asn Phe Met Gin Leu Arg Lys Gin Pro Ala Ile Glu Thr 705 710 715 720 Gin Ile Lys Glu Ala Asn Gin Ala Asn Leu Thr Asp Ala Asp Ile Gin 725 730 735 Asp Thr Ile Asn Glu Leu Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile 740 745 750 Arg Glu Val Met Leu Val Leu Asp Asp Ile Lys Asn Ala Met His Gly 755 760 765 Gin Thr Pro Ser Trp Ile Phe Val Glu Ala Ala Arg Gly Gly Gly Val 770 775 780 Ala Gly Arg Arg Thr Gin Ser Arg Ser Ser Gin Ile Val Glu Ala Tyr 785 790 795 800 Lys Gly Thr Ala Lys Glu Ile Val Ser Glu Lys Val Gin His Glu Leu 805 810 815 Asn Glu Lys Ile Lys Ala Lys Ala Asp Phe Asn Thr Arg Leu Val Leu 820 825 830 Tyr Phe Leu Gin Asn Gly Arg Asp Leu Tyr Thr Asn Glu Ala Ile Asn 835 840 845 Ile Asp Arg Leu Ser Glu Tyr Asp Ile Asp His Ile Leu Pro Gin Ser 850 855 860 Leu Val Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ala Arg 865 870 875 880 Ile Asn Arg Glu Lys Asn Asp Thr Phe Ala Ser Glu Lys Phe Gly Arg 885 895 Page 2395 of 3790 890 Arg Lys Val Ala Leu Lys Asp Leu 1355 1360 Page 2397 of 3790 1039 1358 PRT Lactobacillus pentosus 1039 Page 2398 of 3790 Pro Leu Met Val Val Leu Met Gly Ala Thr Ala Ala Glu Lys Lys Arg 225 230 235 240 Gin Lys Asp Phe Ala Lys Glu Leu Ala Asn Ala Leu Val Gly Leu Lys 245 250 255 Ala Lys Leu Asn Val Val Thr Leu Thr Asn Val Asp Thr Thr Val Val 260 265 270 Lys Asp Trp Thr Phe Thr Leu Glu Glu Ser Gin Asp Lys Leu Pro Glu 275 280 285 Ile Glu Glu Gin Leu Ser Glu Val Gly Gin Gin Ile Met Asp Glu Val 290 295 300 Ile Gin Leu Tyr Ala Ser Val Asn Leu Ala Gin Leu Ile Pro Ala Gly 305 310 315 320 Lys Arg Phe Ser Gin His Met Val Glu Lys Tyr Asn His His Glu Lys 325 330 335 Asn Leu Glu Leu Leu Lys Ala Tyr Ile His Ser Gin Ser Asp Ser Lys 340 345 350 Arg Gly Arg Glu Ile Arg Ala Thr Tyr Asp Arg Tyr Ile Asp Gly Val 355 360 365 Lys Ser Lys Pro Val Thr Gin Glu Met Phe Tyr Lys Asp Leu Met Lys 370 375 380 Tyr Val Glu Ala Asp Ala Thr Ser Asn His Leu Ala Ala Glu Ile Lys 385 390 395 400 Asp Glu Ile Asp Ser Glu Gin Phe Met Pro Lys Leu Arg Thr Lys Gin 405 410 415 Asn Gly Ser Ile Pro Tyr Gin Val Gin Gin Tyr Glu Leu Asp Gin Ile 420 425 430 Ile Ser His Gin Lys Lys Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 435 440 445 Val Ala Glu Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Val 450 455 460 Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Asp 465 470 475 480 Page 2399 of 3790 Gin Gin Ala Thr Ser Gly Ala Gly Phe Ala Trp Met Val Arg Lys Ala 485 490 495 Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Gin Lys Val Asp Arg Ile 500 505 510 Ala Ser Ala Thr Ala Phe Ile Gin Arg Met Gin Thr Thr Asp Thr Tyr 515 520 525 Leu Ile Gly Glu Asp Val Leu Pro Ala Arg Ser Leu Ile Tyr Gin Arg 530 535 540 Phe Met Val Leu Asn Glu Leu Asn Asn Met Arg Val Glu Asp Gin Lys 545 550 555 560 Leu Ala Pro Arg Gin Lys Gin Arg Leu Tyr Asn Gin Val Phe Lys Gin 565 570 575 His Gin His Val Ser Val Lys Asn Ile Gin Gin Asn Leu Met Asp Ala 580 585 590 Gly Glu Tyr Arg Glu Thr Pro Lys Ile Thr Gly Leu Ala Asp Pro Lys 595 600 605 Gly Phe Asn Ser Ser Leu Ser Thr Tyr His Asp Phe Lys Lys Ile Leu 610 615 620 Pro Glu Ala Ile Ala Asp Glu His Lys Arg Ala Asp Ile Glu Lys Ile 625 630 635 640 Ile Leu Trp Ser Thr Thr Phe Glu Asp Ser Ala Ile Phe Lys Gin Lys 645 650 655 Leu Glu Glu Val Ala Trp Leu Thr Asp Ala Gin Arg Lys Gin Leu Ser 660 665 670 Gly Leu Arg Tyr Arg Gly Trp Gly Gin Leu Ser His Lys Leu Leu Thr 675 680 685 Ala Phe Lys Asp Asp Asn Gly Arg Ser Val Met Asp Gly Leu Trp Glu 690 695 700 Thr Ser Asp Asn Phe Met 705 710 Gin Leu Arg Lys Gin Pro Ala 715 Ile Glu Thr 720 Gin Ile Lys Glu Ala Asn Gin Ala Asn Leu Thr Asp Ala Asp Ile Gin Page 2401 of 3790 Asn Phe Pro Lys Leu Arg Glu Val Asn Asp Tyr His His Ala Phe Asp 980 985 990 Ala Ser Leu Thr Ala Phe Ile Gly Met Tyr Leu Leu Lys Gin Tyr Pro 995 1000 1005 Page 2402 of 3790 1355 1040 1358 PRT Lactobacillus plantarum Page 2403 of 3790 Trp Arg Leu Arg Leu Leu Arg Glu Phe Phe Asp Gin Pro Ile Ser Lys 65 70 75 80 Val Asp Ile Asn Phe Phe Ala Arg Arg Lys Tyr Ser Asp Val Ser Pro 85 90 95 Arg Asp Pro Asn Tyr Asn Gly Leu Glu Lys Thr Leu Phe Asn Asp Arg 100 105 110 Ser Asp Gin Asp Phe Tyr His Asp Tyr Pro Thr Ile Tyr His Leu Arg 115 120 125 Glu Ala Leu Met Thr Gin His Arg Lys Phe Asp Val Arg Glu Ile Tyr 130 135 140 Leu Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Arg Asn 145 150 155 160 Asp Ala Ala Thr Ala Tyr Arg Ser Gly Thr Leu Asp Leu Gin Gin His 165 170 175 Phe Glu Thr Leu Asn His Leu Phe Ser Gin Ala Asp Leu Glu Leu Asn 180 185 190 Leu Asn Leu Thr Thr Asp Val Ala Leu Leu Asp Ser Ile Lys Gin Thr 195 200 205 Leu Val Arg Thr Asp Ile Ser Arg Ser Asp Arg Gin Lys Leu Ile Met 210 215 220 Pro Leu Leu Ala Val Leu Thr Gly Ala Thr Thr Ala Glu Lys Lys Arg 225 230 235 240 Gin Lys Ala Val Val Thr Glu Phe Ala Lys Ala Leu Val Gly Asn Lys 245 250 255 Thr Lys Ile Asp Val Leu Thr Leu Thr Asp Ile Asp Ala Thr Glu Ala 260 265 270 Lys Asp Trp Ala Phe Ser Leu Glu Glu Asn Gin Asp Lys Leu Pro Gly 275 280 285 Ile Glu Asp Arg Phe Ser Glu Val Gly Gin Gin Ile Ile Asp Glu Val 290 295 300 Ile Arg Leu Tyr Ala Ser Val Asn Leu Ala Gin Leu Ile Pro Glu Gly 305 310 315 320 Page 2404 of 3790 Lys Arg Phe Ser Gin Ser Met Val Glu Lys Tyr Lys Arg His Gly Glu 325 330 335 Asp Leu Lys Leu Leu Lys Ala Tyr Ile Arg Ser Gin Ser Asp Ala Lys 340 345 350 Arg Gly Arg Ala Ile Arg Ala Thr Tyr Asp Gin Tyr Ile Asp Gly Val 355 360 365 Lys Ser Lys Gin Val Thr Gin Glu Ala Phe Gin Lys Ala Leu Gly Lys 370 375 380 Phe Val Asp Ala Asp Val Asp Leu Asn Ser Trp Ala Ala Gin Ile Lys 385 390 395 400 Gin Ala Ile Asp Ser Glu Gin Phe Met Pro Lys Leu Arg Thr Lys Gin 405 410 415 Asn Gly Ala Ile Pro Tyr Gin Val Gin Gin Asn Glu Leu Asp Gin Ile 420 425 430 Ile Ser Asn Gin Lys Glu Tyr Tyr Pro Trp Leu Gly Glu Glu Asn Pro 435 440 445 Val Ile Lys Arg Arg Gly Lys Phe Pro Tyr Lys Leu Asp Glu Leu Phe 450 455 460 Gly Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Met 465 470 475 480 Gin Ala Ala Thr Ala Asn Ala Gly Phe Ala Trp Met Val Arg Lys Ala 485 490 495 Asp Gly Pro Ile Thr Pro Trp Asn Phe Asp Asp Lys Val Asp Arg Val 500 505 510 Ala Ser Ala Thr Ala Phe Ile Gin Arg Met Gin Thr Thr Asp Thr Tyr 515 520 525 Leu Ile Gly Glu Glu Val Leu Pro Ala Arg Ser Leu Ile Tyr Gin Arg 530 535 540 Phe Met Val Leu Asn Glu Leu Asn Asn Ile Arg Val Asp Asp Gly Gin 545 550 555 560 Leu Thr Pro Arg Gin Lys Gin Arg Leu Tyr Asn Gin Val Phe Lys Lys Page 2406 of 3790 Page 2407 of 3790 Page 2408 of 3790 1355 1041 1361 PRT Lactobacillus rhamnosus Page 2409 of 3790 Leu Thr Pro Gly Ala Ala Lys Asp Phe Asn Thr Asp Lys Val Asp Leu 165 170 175 Glu Asp Ile Phe Pro Ala Leu Thr Glu Ala Tyr Ala Gin Val Tyr Pro 180 185 190 Asp Leu Glu Leu Thr Phe Asp Leu Ala Lys Ala Asp Asp Phe Lys Ala 195 200 205 Lys Leu Leu Asp Glu Gin Ala Thr Pro Ser Asp Thr Gin Lys Ala Leu 210 215 220 Val Asn Leu Leu Leu Ser Ser Asp Gly Glu Lys Glu Ile Val Lys Lys 225 230 235 240 Arg Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys 245 250 255 Thr Lys Phe Asn Leu Ala Leu Gly Thr Glu Val Asp Glu Ala Asp Ala 260 265 270 Ser Asn Trp Gin Phe Ser Met Gly Gin Leu Asp Asp Lys Trp Ser Asn 275 280 285 Ile Glu Thr Ser Met Thr Asp Gin Gly Thr Glu Ile Phe Glu Gin Ile 290 295 300 Gin Glu His Tyr Arg Ala Arg Leu Leu Asn Gly Ile Val Pro Ala Gly 305 310 315 320 Met Ser Leu Ser Gin Ala Lys Val Ala Asp Tyr Gly Gin His Lys Glu 325 330 335 Asp Leu Glu Leu Phe Lys Thr Tyr Leu Lys Lys Leu Asn Asp His Glu 340 345 350 Leu Ala Lys Thr Ile Arg Gly Leu Tyr Asp Arg Tyr Ile Asn Gly Asp 355 360 365 Asp Ala Lys Pro Phe Leu Arg Glu Asp Phe Val Lys Ala Leu Thr Lys 370 375 380 Glu Val Thr Ala His Pro Asn Glu Val Ser Glu Gin Leu Leu Asn Arg 385 390 395 400 Met Gly Gin Ala Asn Phe Met Leu Lys Gin Arg Thr Lys Ala Asn Gly Page 2411 of 3790 Ala Lys Ile Ser Trp Leu Asp Ser Asp Thr Ile Lys Ala Leu Ser Asn 660 665 670 Ile Arg Tyr Arg Gly Trp Gly Gin Phe Ser Arg Lys Leu Leu Asp Gly 675 680 685 Leu Lys Leu Gly Asn Gly His Thr Val Ile Gin Glu Leu Met Leu Ser 690 695 700 Asn His Asn Leu Met Gin Ile Leu Thr Asp Glu Thr Leu Lys Thr Thr 705 710 715 720 Met Ala Glu Leu Asn Gin Asp Lys Leu Lys Ala Asp Asp Ile Glu Asp 725 730 735 Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 740 745 750 Gin Val Leu Arg Val Val Glu Asp Ile Lys His Ala Ala Asn Gly Gin 755 760 765 Asp Pro Ser Trp Leu Tyr Ile Glu Thr Ala Asp Gly Pro Gly Thr Ala 770 775 780 Gly Lys Arg Thr Gin Ser Arg Gin Lys Gin Ile Gin Thr Val Tyr Ala 785 790 795 800 Asn Ala Ala Gin Glu Leu Ile Asp Ser Ala Val Arg Gly Glu Leu Glu 805 810 815 Asp Lys Ile Ala Asp Lys Ala Ser Phe Thr Asp Arg Leu Val Leu Tyr 820 825 830 Phe Met Gin Gly Gly Arg Asp Ile Tyr Thr Gly Ala Pro Leu Asn Ile 835 840 845 Asp Gin Leu Ser His Tyr Asp Ile Asp His Ile Leu Pro Gin Ser Leu 850 855 860 Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Asn Ala Thr Ile 865 870 875 880 Asn Arg Glu Lys Asn Asn Val Phe Ala Ser Thr Leu Phe Ala Ser Lys 885 890 895 Met Ala Ala Thr Trp Arg Lys Trp His Glu Ala Gly Leu Ile Ser Gly 900 905 910 Page 2412 of 3790 Page 2413 of 3790 1042 1361 PRT Lactobacillus rhamnosus Page 2414 of 3790 Arg Lys Gin Val Leu Thr Glu Phe Ala Lys Ala Ile Thr Gly Leu Lys Page 2416 of 3790 Gly Asn Ile Thr Pro Tyr Asn Phe Asp Glu Lys Val Asp Cys Pro Ala 500 505 510 Ser Ala Asn Met Phe Ile Gin Arg Met Lys Asn Thr Asp Thr Tyr Leu 515 520 525 Ile Gly Glu Asp Val Leu Pro Lys Arg Ser Leu Leu Tyr Gin Lys Tyr 530 535 540 Glu Val Leu Asn Glu Leu Asn Asn Val Ser Ile Asp Gly Arg Arg Leu 545 550 555 560 Gly Ala Asp Gin Lys Gin Arg Leu Ile Arg Glu Val Phe Glu Arg His 565 570 575 Ser Ser Val Thr Ile Lys Gin Val Ala Glu Asn Leu Val Ala His Gly 580 585 590 Asp Phe Ala Lys Arg Pro Glu Ile Arg Gly Leu Ala Asp Glu Lys Arg 595 600 605 Phe Leu Ser Ser Leu Ser Thr Tyr His Gin Leu Lys Lys Ile Leu His 610 615 620 Glu Ala Ile Asp Asp Pro Thr Lys Glu His Asp Ile Glu Asn Ile Ile 625 630 635 640 Thr Trp Ser Thr Val Phe Glu Asp Ala Ala Ile Phe Lys Thr Glu Leu 645 650 655 Ala Lys Ile Ser Trp Leu Asp Ser Asp Thr Ile Lys Ala Leu Ser Asn 660 665 670 Ile Arg Tyr Arg Gly Trp Gly Gin Phe Ser Arg Lys Leu Leu Asp Gly 675 680 685 Leu Lys Leu Gly Asn Gly His Thr Val Ile Gin Glu Leu Met Leu Ser 690 695 700 Asn His Asn Leu Met Gin Ile Leu Thr Asp Glu Thr Leu Lys Thr Thr 705 710 715 720 Met Ala Glu Leu Asn Gin Asp Lys Leu Lys Ala Asp Asp Ile Glu Asp 725 730 735 Val Ile Asn Asp Ala Tyr Thr Ser Pro Ser Asn Lys Lys Ala Leu Arg 740 745 750 Page 2417 of 3790 Page 2418 of 3790 Leu Ser Lys Leu Val Lys Ser Ala Lys Thr Val Glu Asn Gly Gin Page 2419 of 3790 1235 1240 1245 1355 1360 1043 1352 PRT Lactobacillus ruminis Lys Tyr Arg Lys Ser Leu Leu Phe Pro Lys Ser Lys Gly Val Thr Tyr Page 2421 of 3790 Asp Tyr Asn Asp Asn Ile Ile Lys Arg Ile Asp Gly Asp Asn Lys Lys 340 345 350 Asp Thr Phe Tyr Lys Arg Val Lys Asn Ile Leu Thr Lys Ile Ser Lys 355 360 365 Glu Tyr Val Asp Gin Asp Val Leu Glu Ser Cys Gly Lys Leu Lys Lys 370 375 380 Leu Ile Asp Glu Asn Lys Leu Phe Ile Arg Gin Arg Thr Ala Ala Asn 385 390 395 400 Gly Val Leu Pro His Gin Leu His Gin Ile Glu Met Arg Lys Ile Ile 405 410 415 Asp Asn Gin Lys Glu Tyr Tyr Pro Trp Leu Ala Glu Pro Asn Pro Asn 420 425 430 Glu Lys Arg Arg Val Tyr Ser Lys Tyr Lys Val Glu Glu Leu Ile Ala 435 440 445 Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Asp Pro Asn Asn Ala 450 455 460 Asp Lys Asn Lys Glu Ala Arg Phe Ser Trp Met Val Arg Lys Lys Asp 465 470 475 480 Gly Glu Ile Thr Pro Trp Asn Phe Tyr Asp Lys Val Asp Trp Ala Glu 485 490 495 Ser Ala Asn Asn Phe Ile Glu Arg Met Lys Ser Lys Asp Thr Tyr Leu 500 505 510 Leu Gly Glu Asp Val Val Pro Lys Glu Ser Met Leu Tyr Gin Lys Tyr 515 520 525 Glu Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn Asp Ser Gly Leu 530 535 540 Ser Asp Ser Phe Glu Asp Val Lys Leu Lys Gin Ala Ile Tyr Asn Asp 545 550 555 560 Leu Phe Lys Lys Gin Lys Ile Val Lys Ile Thr Asp Leu Gin Asn Tyr 565 570 575 Leu Val Gin Asn His Lys Tyr Leu Val Lys Pro Lys Ile Ser Gly Leu 580 585 590 Page 2422 of 3790 Ala Asp Glu Asn Arg Phe Leu Ser Ser Leu Ser Thr Tyr Ser Asp Leu 595 600 605 Lys Thr Ile Phe Gly Asp Lys Val Asp Asp Arg Thr Tyr Phe Asn Asp 610 615 620 Phe Glu Lys Met Val Glu Tyr Ser Thr Val Phe Glu Asp Gly His Asp 625 630 635 640 Tyr Asn Gin Lys Leu Asp Glu Tyr Thr Trp Leu Thr Lys Glu Glu Lys 645 650 655 Tyr Lys Ile Gly Lys Lys Arg Tyr Arg Gly Trp Gly Lys Leu Ser Lys 660 665 670 Lys Leu Leu Thr Gly Leu Arg Asp Lys Asn Asn His Thr Ile Met Asp 675 680 685 Asn Leu Trp Glu Thr Asn Arg Asn Phe Met Gin Ile Gin Thr Ala Asp 690 695 700 Glu Phe Ser Lys Gin Ile Ala Glu Glu Asn Glu Arg His Leu Lys Gly 705 710 715 720 Ser Val Ser Asp Ala Ile Asn Asp Met Tyr Thr Ser Pro Ala Asn Lys 725 730 735 Lys Ala Ile Arg Gin Val Leu Arg Val Val Asp Asp Ile Gin Lys Ala 740 745 750 Met Gly Tyr Ala Pro Ser Ser Ile Ser Leu Glu Phe Ala Arg Glu Asp 755 760 765 Gly Pro Ser Val Arg Thr Val Ser Arg Ala Asn Arg Met Lys Ser Ile 770 775 780 Tyr Glu Lys Tyr Ala Ser Glu Val Ser Glu Glu Val Met Lys Asp Leu 785 790 795 800 Asp Gly Val Ile Lys Asp Lys Lys Gly Leu Asn Asp Arg Leu Tyr Leu 805 810 815 Tyr Phe Glu Gin Gin Gly Lys Asp Met Tyr Ser Gly His Pro Leu Asp 820 825 830 Phe Asp Lys Val Ile Ser Gly Gin Glu Tyr Asp Ile Asp His Ile Leu 835 840 845 Page 2423 of 3790 Ala Pro Asn Ser Arg Lys Ala Ala Leu Lys Tyr Arg Arg Met Pro Page 2425 of 3790 Gly Gly Ile Lys Leu 1325 Ser Lys 1330 Glu Ala Lys Leu Ile Tyr Gin Ser 1335 Pro Thr Gly Leu Phe Glu Arg Val Val Tyr Leu Lys Asp Leu 1340 1345 1350 1044 1339 PRT Lactobacillus salivarius Page 2426 of 3790 Ala Ile Leu Asn Ser Glu Lys Phe Glu Asp Val Glu Lys Ile Ile Leu 195 200 205 Asp Glu Glu Thr Arg Asn Leu Asp Lys Gin Lys Ser Val Gly Lys Leu 210 215 220 Leu Val Glu Asp Lys Lys Lys Lys Asn Ile Val Thr Ala Phe Ser Lys 225 230 235 240 Ala Ile Phe Gly Tyr Lys Phe Asn Ile Glu Asp Leu Leu Leu Ile Glu 245 250 255 Asn Asp Glu Lys Asn Lys Leu Thr Phe Asn Asp Glu Asn Ile Asp Asp 260 265 270 Ile Phe Asn Glu Leu Ser His Ser Leu Asp Asp Lys Gin Met Asp Leu 275 280 285 Leu Thr Lys Thr Arg Glu Ile Tyr Phe Lys Phe Lys Leu Asn Met Ile 290 295 300 Val Pro Thr Gly Tyr Thr Leu Ser Glu Ser Met Ile Glu Lys Tyr Glu 305 310 315 320 Met His Lys Ala His Leu Lys Met Tyr Lys Glu Phe Ile Asn Thr Leu 325 330 335 Asn Thr Lys Asp Arg Lys Ile Leu Lys Asn Ala Tyr Ser Asp Tyr Ile 340 345 350 Asn Thr Glu Lys Ala Lys Ala Ala Asn Ala Gin Glu Asn Phe Tyr Lys 355 360 365 Thr Val Lys Lys Ile Ile Lys Asp Asn Asn Ser Asp Thr Ala Lys Lys 370 375 380 Ile Ile Val Leu Ile Asp Glu Gly Asn Phe Met Pro Lys Gin Arg Thr 385 390 395 400 Gly Glu Asn Gly Val Ile Pro His Gin Leu His Gin Ile Glu Leu Asp 405 410 415 Arg Ile Ile Glu Asn Gin Ala Lys Tyr Tyr Pro Trp Leu Ala Glu Ala 420 425 430 Asn Pro Val Glu Lys Asn Arg Lys Phe Ala Lys Tyr Lys Leu Asp Glu 435 440 445 Page 2427 of 3790 Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Asp Lys 450 455 460 Thr Glu Ser Asn Lys Asn Glu Lys Glu Thr Lys Phe Ala Trp Met Val 465 470 475 480 Arg Lys Ala Lys Gly Thr Ile Thr Pro Trp Asn Phe Glu Asn Leu Val 485 490 495 Asp Arg Thr Glu Ser Ala Asn Arg Phe Ile Lys Arg Met Thr Ser Lys 500 505 510 Asp Thr Tyr Ile Ile Gly Glu Asp Val Leu Pro Ala Ser Ser Leu Leu 515 520 525 Tyr Glu Lys Phe Lys Val Leu Asn Glu Leu Asn Asn Ile Lys Val Asn 530 535 540 Glu Lys Lys Leu Asp Ile Glu Gin Lys Gin Asp Ile Tyr Leu Asn Leu 545 550 555 560 Phe Thr Thr Ala Lys Asn Val Thr Lys Lys Ser Leu Ala Thr Tyr Leu 565 570 575 Asn Cys Ser Ala Asp Ser Ile Ser Gly Leu Ser Asp Gly Glu Lys Phe 580 585 590 Asn Ser Ser Leu Ser Ser Tyr Ile Asp Leu Lys Ala Ile Leu Gly Asn 595 600 605 Ile Val Asp Asp Cys Asn Lys Asn Glu Asp Leu Glu Lys Ile Ile Glu 610 615 620 Tyr Ser Thr Val Phe Glu Asp Gly Asn Ile Tyr Lys Glu Lys Leu Ser 625 630 635 640 Glu Ile Ser Trp Leu Thr Asp Glu Gin Ile Glu Lys Leu Ser Asn Ile 645 650 655 His Phe Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gin Ile 660 665 670 Thr Asn Glu Asn Gly Glu Arg Ile Ile Asp Ala Leu Trp Asn Thr Ser 675 680 685 Asn Asn Phe Met Gin Ile Ile Asn Asp Glu Ser Ile Gin Ala Lys Leu 690 695 700 Page 2428 of 3790 Ala Glu Ile Asn Gly Lys Tyr Ala Gly Lys Ser Asp Leu Glu Asp Ile 705 710 715 720 Leu Ser Glu Ala Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg Gin 725 730 735 Val Met Lys Val Val Glu Asp Ile Glu Lys Ala Met Gin Cys Glu Pro 740 745 750 Thr Ser Ile Ser Ile Glu Phe Thr Arg Lys Lys Gin Lys Ser Arg Leu 755 760 765 Thr Asn Thr Arg Tyr Lys Lys Ile Ser Asp Val Tyr Glu Lys Ile Ala 770 775 780 Asp Glu Val Ile Ser Glu Tyr Glu Leu Arg Lys Leu Gin Ser Glu Leu 785 790 795 800 Asp Ser Asn Ala Asn Asn Met Arg Asp Arg Tyr Tyr Leu Tyr Phe Met 805 810 815 Gin Leu Gly Arg Asp Met Tyr Thr Gly Glu Lys Ile Asn Ile Asp Glu 820 825 830 Leu His Gin Arg Tyr Asp Ile Asp His Ile Leu Pro Gin Ser Phe Ile 835 840 845 Lys Asp Asp Ser Ile Asn Asn Arg Val Leu Thr Arg Lys Asp Val Asn 850 855 860 Asn Lys Glu Lys Ser Asp Lys Thr Ala Ala Asp Leu Tyr Ala Val Glu 865 870 875 880 Met Ser Asp Phe Trp Arg Lys Leu Arg Lys Gin Gly Leu Ile Thr Glu 885 890 895 Gin Lys Tyr Lys Asn Leu Leu Thr Lys Ser Asp Ser Ile Asp Lys Tyr 900 905 910 Ala Lys Lys Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Ser Gin Val 915 920 925 Val Lys Leu Val Ala Asn Ile Leu Gin Asp Lys Tyr Ser Asp Thr Lys 930 935 940 Ile Ile Glu Val Arg Ala Lys Leu Asn Ser Asn Leu Arg Glu Glu Tyr Page 2430 of 3790 Gly 1045 629 PRT Lactobacillus salivarius Page 2431 of 3790 Arg Arg Gly Phe Arg Thr Gin Arg Arg Arg Leu Asn Arg Arg Lys Trp 50 55 60 Arg Leu Lys Leu Leu Glu Glu Ile Phe Asp Pro Tyr Met Ala Glu Val 65 70 75 80 Asp Glu Tyr Phe Phe Ala Arg Leu Lys Asp Ser Asn Leu Ser Pro Lys 85 90 95 Asp Ser Asn Lys Lys Tyr Leu Gly Ser Leu Leu Phe Pro Asp Ile Ser 100 105 110 Asp Ser Asn Phe Tyr Asp Lys Tyr Pro Thr Ile Tyr His Leu Arg Arg 115 120 125 Asp Leu Met Glu Lys Asp Glu Lys Phe Asp Leu Arg Glu Ile Tyr Leu 130 135 140 Ala Ile His His Ile Val Lys Tyr Arg Gly Asn Phe Leu Glu Asn Val 145 150 155 160 Pro Ala Lys Asn Tyr Lys Asn Ser Gly Ala Ser Ile Gly Phe Leu Leu 165 170 175 Glu Glu Val Asn Asn Leu Tyr Lys Asp Ile Val Gly Asp Glu Asn Val 180 185 190 Thr Ile Leu Asn Ser Glu Lys Phe Glu Asp Val Glu Lys Ile Ile Leu 195 200 205 Asp Asp Gly Ile Arg Asn Leu Asp Lys Gin Lys Gly Val Gly Lys Leu 210 215 220 Leu Val Glu Asp Lys Lys Asn Lys Asn Leu Val Thr Ala Phe Ser Lys 225 230 235 240 Ala Ile Phe Gly Tyr Lys Phe Asn Ile Glu Asp Leu Leu Leu Val Glu 245 250 255 Gly Asp Glu Lys Ser Lys Leu Thr Phe Asn Asp Glu Asn Ile Asp Asp 260 265 270 Ile Phe Asn Glu Leu Ser His Ser Leu Asp Asp Arg Arg Met Asp Leu 275 280 285 Leu Thr Lys Thr Arg Glu Ile Tyr Phe Lys Phe Lys Leu Asn Met Ile 290 295 300 Page 2432 of 3790 Val Pro Thr Gly Tyr Thr Leu Ser Glu Ser Met Ile Glu Lys Tyr Glu 305 310 315 320 Ile His Lys Ala His Leu Lys Met Tyr Lys Glu Phe Ile Asn Thr Leu 325 330 335 Asn Ser Lys Asp Arg Lys Ile Leu Lys Asn Ala Tyr Thr Asp Tyr Ile 340 345 350 Asn Asn Glu Lys Ala Lys Ala Ala Asn Ala Gin Glu Asn Phe Tyr Lys 355 360 365 Thr Val Lys Lys Thr Ile Lys Asp Asn Asp Ser Asp Ile Val Lys Lys 370 375 380 Ile Ile Asp Leu Ile Asp Glu Gly Asn Phe Met Pro Lys Gin Arg Thr 385 390 395 400 Gly Glu Asn Gly Val Ile Pro His Gin Leu His Gin Ile Glu Leu Asp 405 410 415 Arg Ile Ile Glu Asn Gin Ala Lys Tyr Tyr Pro Trp Leu Ala Glu Glu 420 425 430 Asn Pro Val Glu Lys Asn Arg Lys Phe Ala Lys Tyr Lys Leu Asp Glu 435 440 445 Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Val Asp Lys 450 455 460 Thr Glu Ser Asn Lys Asn Glu Lys Glu Thr Lys Phe Ala Trp Met Val 465 470 475 480 Arg Lys Ser Lys Gly Thr Ile Thr Pro Trp Asn Phe Glu Asn Leu Val 485 490 495 Asp Arg Thr Glu Ser Ala Asn Arg Phe Ile Lys Arg Met Thr Ser Lys 500 505 510 Asp Thr Tyr Ile Ile Gly Glu Asp Val Leu Pro Ala Ser Ser Leu Leu 515 520 525 Tyr Glu Lys Phe Lys Val Leu Asn Glu Leu Asn Asn Ile Lys Val Asn 530 535 540 Glu Lys Lys Leu Asp Ile Glu Gin Lys Gin Asn Ile Tyr Leu Lys Leu 545 550 555 560 Page 2433 of 3790 Page 2434 of 3790 Asn Phe Tyr Lys Thr Ile Lys Lys Thr Ile Lys Asp Asn Asn Ser Asp 115 120 125 Thr Ala Lys Lys Ile Ile Gly Leu Ile Asp Glu Gly Asn Phe Met Pro 130 135 140 Lys Gin Arg Thr Gly Glu Asn Gly Val Ile Pro His Gin Leu His Gin 145 150 155 160 Ile Glu Leu Asp Arg Ile Ile Glu Asn Gin Ala Lys Tyr Tyr Pro Trp 165 170 175 Leu Ala Glu Glu Asn Pro Val Glu Lys Asn Arg Lys Phe Ala Lys Tyr 180 185 190 Lys Leu Asp Glu Leu Val Thr Phe Arg Val Pro Tyr Tyr Val Gly Pro 195 200 205 Leu Val Asp Lys Thr Glu Ser Asn Lys Asn Glu Lys Glu Thr Lys Phe 210 215 220 Ala Trp Met Val Arg Lys Ala Lys Gly Thr Ile Thr Pro Trp Asn Phe 225 230 235 240 Glu Asn Leu Val Asp Arg Thr Glu Ser Ala Asn Arg Phe Ile Lys Arg 245 250 255 Met Thr Ser Lys Asp Thr Tyr Ile Ile Gly Glu Asp Val Leu Pro Ala 260 265 270 Ser Ser Leu Leu Tyr Glu Lys Phe Lys Val Leu Asn Glu Leu Asn Asn 275 280 285 Ile Lys Val Asn Lys Lys Lys Leu Asp Val Glu Gin Lys Gin His Val 290 295 300 Tyr Leu Asp Leu Phe Thr Thr Arg Lys Asn Val Thr Lys Asp Asn Leu 305 310 315 320 Ala Thr Ser Leu Asn Cys Asp Val Glu Ser Ile Thr Gly Leu Ser Asp 325 330 335 Asn Glu Lys Phe Asn Ser Ser Leu Ser Ser Tyr Ile Asp Leu Lys Ala 340 345 350 Ile Leu Gly Asn Ala Val Asp Asp Cys Asn Lys Asn Lys Asp Leu Glu 355 360 365 Page 2435 of 3790 Lys Ile Ile Glu Tyr Ser Thr Ile Phe Glu Asp Gly Asn Ile Tyr Lys 370 375 380 Glu Lys Leu Ser Glu Ile Ser Trp Leu Thr Asp Glu Gin Ile Glu Lys 385 390 395 400 Leu Ser Asn Ile His Phe Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu 405 410 415 Leu Thr Gin Ile Thr Asn Glu Asn Gly Glu Arg Ile Ile Asp Ala Leu 420 425 430 Trp Asn Thr Ser Asn Asn Phe Ile Gin Ile Ile Ser Asp Glu Ser Ile 435 440 445 Gin Ala Lys Leu Ala Glu Ile Asn Gly Glu Tyr Ala Asp Lys Ser Asn 450 455 460 Leu Glu Asp Ile Leu Asp Glu Ala Tyr Thr Ser Pro Gin Asn Lys Lys 465 470 475 480 Ala Ile Arg Gin Val Met Lys Val Val Glu Asp Ile Glu Lys Ala Met 485 490 495 Lys Cys Lys Pro Thr Ser Ile Ala Ile Glu Phe Thr Arg Arg Lys Gly 500 505 510 Lys Ser Lys Leu Thr Asn Thr Arg Tyr Lys Lys Ile Ser Glu Thr Tyr 515 520 525 Glu Lys Ile Thr Asp Glu Leu Ile Ser Glu Tyr Glu Leu Gly Lys Leu 530 535 540 Gin Ser Lys Leu Asp Ser Lys Ala Asn Asn Met Arg Asp Ile Tyr Tyr 545 550 555 560 Leu Tyr Phe Met Gin Leu Gly Arg Asp Met Tyr Thr Gly Glu Lys Ile 565 570 575 Asn Ile Asp Glu Leu His Gin Tyr Tyr Asp Ile Asp His Ile Phe Pro 580 585 590 Arg Ser Phe Ile Lys Asp Asn Ser Leu Asn Asn Arg Val Leu Thr Arg 595 600 605 Lys Glu Ile Asn Asn Asn Glu Lys Ala Asp Arg Thr Ala Ala Asp Leu 610 615 620 Page 2436 of 3790 Tyr Ala Val Lys Met Gly Asp Phe Trp Arg Lys Leu Arg Lys Gin Gly 625 630 635 640 Leu Ile Thr Glu Lys Lys Tyr Lys Asn Leu Leu Thr Arg Thr Asp Ser 645 650 655 Ile Asp Lys Tyr Thr Lys Gin Ser Phe Ile Lys Arg Gin Leu Val Glu 660 665 670 Thr Ser Gin Val Val Lys Met Ala Ala Asn Ile Leu Gin Asp Lys Tyr 675 680 685 Ser Asn Thr Lys Ile Ile Glu Val Arg Ala Arg Leu Asn Ser Asp Leu 690 695 700 Arg Lys Glu Tyr Glu Leu Ile Lys Asn Arg Glu Val Asn Asp Tyr His 705 710 715 720 His Ala Ile Asp Gly Tyr Leu Thr Ile Phe Ile Gly Gin Tyr Leu Tyr 725 730 735 Lys Thr Tyr Pro Lys Leu Arg Ser Tyr Phe Val Tyr Asp Asp Phe Lys 740 745 750 Lys Leu Asp Ser Asn Tyr Leu Lys His Met Asp Lys Phe Asn Phe Ile 755 760 765 Trp Lys Leu Glu Asp Lys Lys Ala Glu Asp Val Tyr Asp Asn Val Asn 770 775 780 Asn Glu Phe Ile Leu Asn Val Pro Lys Met Lys Asp Tyr Ile Gin Lys 785 790 795 800 Ile Tyr Asn Tyr Lys Tyr Met Leu Ile Ser Lys Glu Val Thr Thr Glu 805 810 815 Ser Gly Ala Phe Tyr Xaa Glx Thr Lys Tyr Asn Ala Lys Thr Ile Asn 820 825 830 Leu Ile Pro Ile Lys Lys Asp Lys Pro Thr Asn Ile Tyr Gly Gly Tyr 835 840 845 Lys Gly Lys Val Ser Ser Tyr Met Met Leu Val Lys Ile Gin Lys Lys 850 855 860 Lys Glu Val Ile Tyr Lys Phe Val Gly Val Pro Arg Leu Trp Thr Asp Page 2437 of 3790 865 870 875 880 Glu Leu Asp Arg Leu Ile Asp Thr Asp Glu Lys Lys Ala Leu Leu Lys 885 890 895 Lys 1047 1419 PRT Lactobacillus sp. Gly Gly Asp Glu Arg Thr Ile Leu Asn Thr Lys Ile Leu Asp Asp Leu Page 2439 of 3790 Ala Glu Lys Asp Phe Leu Pro Leu Gin Arg Ser Asn Ser Asn Gly Val 435 440 445 Ile Pro Asn Gin Leu His Gin Ile Glu Leu Asp Glu Ile Ile Lys Lys 450 455 460 Gin Ser Lys Tyr Tyr Pro Phe Leu Gly Glu Thr Asn Glu His Ala Ser 465 470 475 480 Ala Asp Val Ala Arg Lys Ala Pro Thr Lys Leu Asp Gin Leu Leu Thr 485 490 495 Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Ile Thr Lys Glu Glu Gin 500 505 510 Glu Glu Gin Asp Gly His Ser Phe Ala Trp Met Ile Arg Lys Asn Pro 515 520 525 Lys Asp His Glu Lys Ile Thr Pro Trp Asn Phe Asp Glu Lys Val Asp 530 535 540 Arg Met Ala Ser Ala Thr Gin Phe Ile Lys Arg Met Thr Thr Lys Asp 545 550 555 560 Thr Tyr Leu Leu Gly Glu Asp Val Leu Pro Ser Ser Ser Leu Lys Tyr 565 570 575 Gin Leu Phe Thr Val Leu Asn Glu Leu Asn Asn Leu Arg Ile Asn His 580 585 590 Lys Lys Leu Thr Arg Glu Glu Lys Glu Gin Val Ile Glu Asp Leu Phe 595 600 605 Lys Lys Tyr Lys Thr Val Lys Ala Asp Lys Phe Lys Asn Tyr Trp Gin 610 615 620 Lys Gly His Ala Gly Leu Asp Val Lys Ile Gin Gly Met Ala Asp Pro 625 630 635 640 Glu Lys Phe Asn Ser Thr Met Ser Thr Tyr Ile Asp Leu Gin Lys Ile 645 650 655 Phe Gly Asp Gin Leu Asp Asp Ala Gin Arg Gin Asn Asp Phe Glu Lys 660 665 670 Ile Ile Glu Tyr Ser Thr Ile Phe Glu Asp Arg Lys Ile Leu Gly Glu 675 680 685 Page 2440 of 3790 Lys Leu Arg Ala Asp Phe Val Trp Leu Ser Glu Asp Gin Ile Lys Arg 690 695 700 Leu Cys Arg Leu Arg Leu Gin Gly Trp Gly Arg Leu Ser Leu Lys Leu 705 710 715 720 Leu Thr Arg Leu Thr Asp Ala Asp Gly Gin Asn Val Leu Glu Arg Leu 725 730 735 Leu Asn Ser Asn Asp Asn Phe Met Gin Ile Val Lys Asp Pro Val Ile 740 745 750 Lys Ala Lys Ile Glu Gin Lys Asn Gin Lys Leu Leu Arg Ala Asp Trp 755 760 765 Ser Glu Asn Ala Thr Glu Ser Ile Leu Asp Glu Ala Tyr Thr Ser Pro 770 775 780 Gin Asn Lys Lys Ala Ile Arg Gin Val Met Arg Val Val His Asp Ile 785 790 795 800 Val Lys Ala Cys Asp Gly Asn Leu Pro Ala Lys Phe Ala Ile Glu Phe 805 810 815 Ala Arg Ser Gin Asp Asp Asp Pro Lys Arg Thr Val Ala Arg Ala Asp 820 825 830 Arg Leu Gin Lys Ile Tyr Ala Gin Ile Ser Asp Glu Val Val Ser Gin 835 840 845 Gly Val Lys Asp Gin Leu Ser Gly Met Lys Ser Leu Lys Asp Arg Tyr 850 855 860 Tyr Leu Tyr Phe Met Gin Gly Gly Arg Asp Ala Tyr Thr Gly Lys Pro 865 870 875 880 Leu Asn Ile Asp Arg Leu Ser Asp Tyr Asp Ile Asp His Ile Met Pro 885 890 895 Gin Ser Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Val Thr 900 905 910 Arg Ala Val Asn Asn Gin Lys Ser Asp Asn Val Pro Val Leu Leu Tyr 915 920 925 Gly Asn His Leu Val Ala Asp Leu Gly Ile Thr Ile Arg Glu Met Trp 930 935 940 Page 2441 of 3790 Ser Gly Asn Lys Asp Ala Tyr Phe Val Leu Ala Gin Val Val Lys Page 2443 of 3790 Val Ser Asp Leu Leu Lys 1415 1048 1289 PRT Lactobacillus versmoldensis Page 2444 of 3790 Leu Ser Ser Arg His Ile Asp Ser Glu Leu Pro Ile Ile Leu Ser Glu 210 215 220 Leu Asn Glu Gin Gin Glu Asn Ile Ile Thr Ile Ala Asn Ser Ile Phe 225 230 235 240 Gly Ser Ile Ile Leu Lys Asp Phe Leu Gly Asp Glu Thr Ser Ile Ser 245 250 255 Ala Ala Lys Val Ile Ser Phe Glu Asp His Lys Gin Asp Leu Gin Lys 260 265 270 Leu Lys Thr Met Trp Arg Glu Thr Ser Asn Lys Glu Ala Val Lys Ala 275 280 285 Gly Lys Lys Ala Tyr Glu Asp Tyr Ile Gly His Glu Asp Ser Glu Thr 290 295 300 Phe Tyr Lys Lys Ile Lys Lys Phe Leu Glu Lys Ala Gin Pro Val Asp 305 310 315 320 Leu Ala Asn Lys Ala Leu Ala Glu Ile Glu Leu Glu Asn Tyr Leu Pro 325 330 335 Lys Gin Arg Asn Arg Asn Asn Thr Val Ile Pro Tyr Gin Leu Asn Glu 340 345 350 Asn Glu Leu Ile Ala Ile Leu Asp His Gin Glu Lys Tyr Tyr Pro Phe 355 360 365 Leu Lys Glu Asn Arg Asp Lys Ile Leu Ser Leu Leu Thr Phe Arg Ile 370 375 380 Pro Tyr Tyr Val Gly Pro Leu Gin Asp Ser Asn Asn Asn Arg Phe Ser 385 390 395 400 Trp Met Thr Arg Lys Ala Ser Gly Ala Ile Arg Pro Trp Asn Phe Ser 405 410 415 Glu Lys Val Asn Val Glu Gin Ser Ser Asn Asp Phe Ile Lys Arg Met 420 425 430 Arg Ser Thr Asp Thr Tyr Leu Ile Gly Glu Pro Val Leu Pro Lys Lys 435 440 445 Ser Leu Ile Tyr Gin Cys Tyr Glu Val Leu Ser Glu Leu Asn Asn Thr 450 455 460 Page 2445 of 3790 Arg Val Lys Asp Gly Ser Ser Asn Pro Lys Arg Leu Asp Val Thr Ile 465 470 475 480 Lys Gin Arg Ile Tyr Asn Glu Ile Phe Lys Asn Gin Lys Ser Val Ser 485 490 495 Val Lys Val Leu Gin Asn Trp Leu Ile Lys Glu Ser Tyr Phe Lys Ser 500 505 510 Pro Glu Ile Ser Gly Leu Ala Asp Lys Lys Lys Tyr Leu Ser Ser Leu 515 520 525 Ser Thr Tyr Ile Asp Phe Lys Lys Ile Phe Gly Gin Arg Phe Val Asp 530 535 540 Asp Pro Val Asn Ser Pro Gin Leu Glu Glu Leu Ala Glu Trp Leu Thr 545 550 555 560 Leu Phe Glu Asp Lys Lys Ile Leu Leu Ile Lys Leu Gin Asn Ser Lys 565 570 575 Tyr Ser Tyr Asp Gin Ala Thr Ile Asn Lys Leu Ser Thr Met Arg Tyr 580 585 590 Gin Gly Thr Gly Lys Leu Ser Lys Lys Leu Leu Val Asp Leu Lys Thr 595 600 605 Thr Lys Lys Ser Ile Gly Lys Ser Gly Ala Glu Ser Leu Ser Ile Leu 610 615 620 Asp Leu Met Trp Ser Thr Lys Asp Asn Phe Met Gin Ile Ile His Asp 625 630 635 640 Ala Asp Tyr Thr Phe Glu Gin Gin Ile Lys Glu Phe Asn Tyr Asp Thr 645 650 655 Glu Asp Glu Leu Thr Pro Leu Glu Lys Val Ala Asn Leu His Gly Ser 660 665 670 Pro Ala Leu Lys Arg Gly Leu Asn Gin Ser Ile Lys Val Val Ala Asp 675 680 685 Ile Val Lys Phe Met Gly His Asp Pro Glu Lys Ile Phe Ile Glu Phe 690 695 700 Thr Arg Ser Asp Asp Phe Ser Lys Leu Thr Ile Ser Arg Tyr Arg Arg 705 710 715 720 Page 2446 of 3790 Ile Lys Lys Gin Tyr Leu Glu Ile Ala Lys Ala Ile Lys Lys Ile Pro 725 730 735 Ala Glu Phe Lys Asp Ile Lys Glu Tyr Gin Thr Gin Leu Glu Glu Asn 740 745 750 Lys Gly Lys Leu Ala Ser Glu Arg Leu Met Leu Tyr Phe Leu Gin Cys 755 760 765 Gly His Ser Leu Tyr Ser Asn Lys Pro Ile Asp Leu Asn Met Ile Asn 770 775 780 Ser Ser Lys Tyr His Val Asp His Ile Leu Pro Gin Ser Tyr Ile Lys 785 790 795 800 Asp Asp Ser Leu Glu Asn Lys Ala Leu Val Leu Ala Ser Glu Asn Glu 805 810 815 Asn Lys Ile Asp Asn Met Leu Ile Ser His Asp Ile Ile Ala Thr Asn 820 825 830 Leu Pro Arg Trp Gin Ala Leu Lys Asp Gin Asn Leu Met Gly Ser Lys 835 840 845 Lys Phe Ala Asp Leu Thr Arg Thr Thr Val Thr Glu Asn Gin Lys Lys 850 855 860 Gly Phe Ile Gin Arg Gin Leu Val Gin Thr Ser Gin Ile Val Lys Asn 865 870 875 880 Ile Thr Leu Ile Leu Asn Asp Leu Tyr Lys Asn Thr Ser Cys Ile Glu 885 890 895 Thr Arg Ala Thr Leu Ser Ser Glu Phe Arg Lys Ala Phe Ser Asn Phe 900 905 910 Asp Glu Thr Thr Tyr His Tyr Gin Phe Pro Glu Phe Val Lys Asn Arg 915 920 925 Asp Val Asn Asp Phe His His Ala Gin Asp Ala Phe Leu Ala Cys Val 930 935 940 Ile Gly Glu Tyr Gin Leu Lys Lys Tyr Pro Lys Asp Asn Leu Arg Leu 945 950 955 960 Val Tyr Asp Gin Tyr Ser Lys Phe Leu Asp Ser Leu Lys Lys Asp Thr Page 2447 of 3790 965 970 975 Arg Lys Lys Asn Gly Arg Met Pro Arg Tyr Thr Gin Asn Gly Phe Ile 980 985 990 Ile Gly Ser Met Phe Asn Gly Lys Thr Tyr Val Asp Asp Asn Gly Glu 995 1000 1005 Page 2448 of 3790 1049 1372 PRT Legionella pneumophila Page 2449 of 3790 Leu Leu Pro Ser Glu Ser Glu His Asn Phe Ile Asp Trp Phe Leu Gin 130 135 140 Lys Met Gin Ser Ser Glu Phe Arg Lys Ile Leu Val Ser Lys Val Glu 145 150 155 160 Glu Lys Lys Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 165 170 175 Asn Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 180 185 190 Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn 195 200 205 Gin Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu Ser Asn 210 215 220 Leu Leu Gly His Leu Ser Asn Leu Gin Trp Lys Asn Leu His Arg Tyr 225 230 235 240 Leu Ala Lys Asn Pro Lys Gin Phe Asp Glu Gin Thr Phe Gly Asn Glu 245 250 255 Phe Leu Arg Met Leu Lys Asn Phe Arg His Leu Lys Gly Ser Gin Glu 260 265 270 Ser Leu Ala Val Arg Asn Leu Ile Gin Gin Leu Glu Gin Ser Gin Asp 275 280 285 Tyr Ile Ser Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 290 295 300 Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gin Ser Leu Leu 305 310 315 320 Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 325 330 335 Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 340 345 350 His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gin 355 360 365 Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gin Arg Tyr Leu Asp Leu Asn 370 375 380 Page 2450 of 3790 Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gin Leu Ser Phe Leu Gly 385 390 395 400 Gin Gly Lys Gin Leu Pro Ala Asn Leu Ile Glu Thr Gin Lys Glu Met 405 410 415 Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gin Ile Ala 420 425 430 Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gin Gly Ile Trp Phe 435 440 445 Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 450 455 460 Lys Gin Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 465 470 475 480 Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Asn Phe Trp Asn 485 490 495 Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 500 505 510 Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 515 520 525 Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 530 535 540 Ile Ile Gin Thr Ile Pro Asp Ile Ile Gin Ala Ile Gin Ser His Leu 545 550 555 560 Gly His Asn Asp Ser Gin Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 565 570 575 Ser Gin Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 580 585 590 Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gin Lys Thr 595 600 605 Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 610 615 620 Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gin Arg Leu Ala 625 630 635 640 Page 2451 of 3790 Tyr Glu Ile Ala Met Ala Lys Trp Glu Gin Ile Lys His Ile Pro Asp 645 650 655 Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gin Asn Arg Phe Glu 660 665 670 Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Gly Ser Ser Asp Lys Thr 675 680 685 Leu Glu Gin Ala Ile Glu Lys Gin Asn Ile Gin Trp Glu Glu Lys Phe 690 695 700 Gin Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 705 710 715 720 Ser Ile Gly Gly Gin Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 725 730 735 Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Ala Asn Leu Ile 740 745 750 Tyr Cys Ser Ser Gin Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 755 760 765 Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gin Phe Gly Thr Asp 770 775 780 Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gin Asn Val Ala Asn Ile 785 790 795 800 Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gin Gin Lys Ala 805 810 815 Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys Thr 820 825 830 Ile Thr Lys Phe Leu Met Ser Gin Gin Lys Ala Arg Val Asn Gly Thr 835 840 845 Gin Lys Phe Leu Gly Lys Gin Ile Met Glu Phe Leu Ser Thr Leu Ala 850 855 860 Asp Ser Lys Gin Leu Gin Leu Glu Phe Ser Ile Lys Gin Ile Thr Ala 865 870 875 880 Glu Glu Val His Asp His Arg Glu Leu Leu Ser Lys Gin Glu Pro Lys 885 895 Page 2452 of 3790 890 Thr Lys Asp Trp Glu Arg Leu Phe Asn His Pro Asn Phe Leu Ala 1115 1120 1125 Page 2453 of 3790 Page 2454 of 3790 Lys Lys Gin Pro 1370 1050 907 PRT Leptospira inadai Page 2455 of 3790 Asn Ser Lys Gin Glu Arg Ile Lys Ala Ala Ser Arg Glu Leu Cys Pro 210 215 220 Tyr Thr Gly Lys Lys Ile Ser Lys Gly Glu Ile Asp His Ile Leu Pro 225 230 235 240 Arg Ser Trp Thr Gin Lys Gin Phe Gly Thr Ala Leu Asn Ala Glu Ala 245 250 255 Asn Leu Ile Tyr Ala Ser Arg Glu Gly Asn Gin Ser Lys Gly Asn Arg 260 265 270 Glu Tyr Gly Leu Asn Asp Leu Asp Glu Lys Tyr Leu Asn Ile Ile Phe 275 280 285 Gly Thr Lys Glu Val Asp Ser Ile Gin Arg Asn Ile Ser Asp Thr Ile 290 295 300 Asp Arg Leu Asp Ile Glu Arg Gly Thr Thr Arg Ile Val Phe Asp Arg 305 310 315 320 Leu Ala Pro Asn Glu Arg Asp Cys Leu Arg His Ala Leu Phe Ile Lys 325 330 335 Ser Leu Arg Pro Lys Val Phe Glu Leu Leu Ser Gly Gin Leu Lys Ala 340 345 350 Arg Val Asn Gly Thr Gin Leu Tyr Leu Ala Lys Arg Ile Arg Ser Leu 355 360 365 Leu Leu Lys Asn Gin Asp Phe Ile Thr Lys Ser Leu Ile Ile Lys Val 370 375 380 Pro Ser Phe Ser Phe Tyr Glu Pro Arg Thr Val Asp Leu Pro Tyr Met 385 390 395 400 Arg Lys Glu Leu Ala Glu Lys Phe Pro Asn Leu Gly Lys Gin Asn Pro 405 410 415 Gin Pro Thr Gly Ser His Ile Ile Asp Ala Ala Met Val Met Ala Tyr 420 425 430 Ala Val Glu Thr Asp Ser Gly Asn Leu Ser Phe Gly Ser Lys Asp Lys 435 440 445 Ser Glu Gly Phe Asp Ser Glu Ser Leu Ser Arg Phe Leu Pro Ser Asn 450 455 460 Page 2456 of 3790 Ile Gin Phe Leu Ser Ile Lys Ser Lys Asp Lys Thr Asp Ser Lys Tyr 465 470 475 480 Pro Tyr Lys Lys Pro Leu Phe Lys Asp Gly Val Phe Gly Glu Arg Phe 485 490 495 Leu Pro Ile Leu Ile Ala Glu Lys Gly Leu Arg Val Gly Tyr Thr Leu 500 505 510 Glu Asn Ser Leu Glu Val Asn Ser Glu Asn Pro Glu Glu Phe Phe Asn 515 520 525 Val Leu Lys Pro Tyr Leu Leu Phe Lys Arg Lys Pro Ile Glu Ser Asn 530 535 540 Tyr Gin Thr Leu Val Ala Phe Ala Gin Lys Asp Lys Arg Gly Tyr Ile 545 550 555 560 Val Leu Pro Val Asn Lys Pro Lys Ala Leu Glu Ser Ile Ser Gin Arg 565 570 575 Lys Ser Asp Pro His Thr Ser Ile Leu Lys Asn Ile Leu Tyr Thr Val 580 585 590 Ser Arg Glu Ser Ile Pro Ser Leu Ile Phe Asp Lys Asn Thr Leu Ile 595 600 605 Pro Glu Ile Lys Ser Asn Lys Val Asn Trp Gly Asp Lys Leu Glu Lys 610 615 620 Lys Phe Arg Ile Lys Ile Glu Ile Lys Leu Tyr Gly Lys Lys Ile Ala 625 630 635 640 Asp Gly Phe Ile Arg Tyr Pro Gly Lys Thr Glu Trp Glu Lys Leu Leu 645 650 655 Leu Thr Glu Pro Leu Lys Gly Leu Val Lys Asn Lys Thr Leu Thr Pro 660 665 670 Lys Trp Phe Asp Ser Leu Glu Asn Leu Ala Gly Leu Asp Asp His Phe 675 680 685 Lys Asp Thr Ser Asn Pro Glu Ala Lys His Lys Arg Lys Ser Asn His 690 695 700 Tyr Ala Leu Pro Val Pro Lys Gly Pro Ser Gly Gly Phe Arg Ile Arg Gly Ile Val Tyr Thr Thr Tyr Gin Pro Asn Ala Leu Pro Thr Glu Ile Page 2458 of 3790 25 30 His Gly Ala Thr Ile Ile Ser Asp Asn Leu Lys Leu Ser Gin Val Asp 35 40 45 Arg Arg Ala Lys Arg His Gin Arg Arg Asn Tyr Thr Arg Met Lys Leu 50 55 60 Ala Arg Arg Leu Val Tyr Leu Ile Ile Arg Tyr His Tyr Arg Ile Pro 65 70 75 80 Glu Gin Asp Leu Thr Pro Glu Val Lys Thr Ser Leu Gin Ser Leu Leu 85 90 95 Thr Arg Arg Gly Tyr Thr Phe Gin Ser Ile Glu Thr Glu Gly Asn Glu 100 105 110 Leu Gly Gin Ala Pro Trp Gly Glu Ile Glu Asp Tyr Phe Pro Asn Val 115 120 125 Gin Asp Tyr Glu Lys Ser Leu Pro Ile Gin Thr Val Leu Tyr His Phe 130 135 140 Phe Ser Ser Glu Asn Leu Glu Leu Asn Lys Leu Val Pro Ser Lys Glu 145 150 155 160 Pro Glu Thr Lys Glu Asp Lys Asn Ile Leu Lys Tyr Ile Arg Glu Gin 165 170 175 Lys Glu Ala Phe Glu Ser Glu Gin Asn Asn Gly Ala Arg His Arg Leu 180 185 190 Lys Tyr Phe Glu Glu Ile Lys Glu Asp Phe Pro Arg Lys Ile Lys Leu 195 200 205 Met Glu Cys Leu Gin Lys Asn Lys Ile Glu Glu Lys Lys Phe Leu Asn 210 215 220 Leu Ile Gin Asn Ile Ser Asn Leu Gin Ile Lys Pro Leu Arg Ala Tyr 225 230 235 240 Phe Asn Asp Lys Asp Met Lys Glu Lys Glu Ile Trp Glu Pro Arg Arg 245 250 255 Leu His Thr Tyr Ile Ala Arg Trp Ile Arg Ser Trp His Ile Asp Pro 260 265 270 Page 2459 of 3790 Page 2460 of 3790 Page 2461 of 3790 Phe Leu Asn Thr Ala Asp Lys Ile Asn Ala Glu Asn Ser Phe Asn Val 165 170 175 Asp Leu Phe Ile Ala Ala Leu Asp Glu Tyr Asn Glu Phe Leu Glu Thr 180 185 190 Pro Ile Thr Ser Ile Lys Asp Ala Gin Leu Phe Ser Asp Lys Leu Thr 195 200 205 Asp Ile Asn Ala Arg Asn Lys Ser Val Arg Val Glu Asn Ala Met Ser 210 215 220 Glu Thr Tyr Asp Asp Lys Ser Lys Ile Phe Lys Ala Ile Leu Thr Ala 225 230 235 240 Leu Val Gly Asn Thr Ala Asn Phe Gin Thr Ile Phe Asp Leu Ser Asp 245 250 255 Leu Glu Lys Asp Glu Ala Lys Asn Phe Lys Phe Lys Leu Asp Leu Glu 260 265 270 Asp Val Glu Thr Lys Leu Asp Val Val Arg Ala Lys Leu Ser Asp Glu 275 280 285 Gin Asn Ala Phe Leu Glu Ala Val Leu Ile Ala Tyr Asp Gly Ile Thr 290 295 300 Leu Lys Met Ile Leu Gly Asp Tyr Lys Ser Ile Ser Gin Ser Met Ile 305 310 315 320 Glu Ser Tyr Lys Ser His Gin Arg Asp Trp Lys Tyr Ile Lys Asn Asn 325 330 335 Val Arg Leu Asn Glu Gin Lys Ile Glu Pro Asp Lys Asn Ser Val Lys 340 345 350 Phe Phe Lys Leu Asp Pro Lys Lys Leu Ile Tyr Pro Ser Asn Leu Ala 355 360 365 Tyr Leu Gin Val Ile Ser Ser Asn Glu Asp Glu His Arg Lys Gly Leu 370 375 380 Asp Tyr Phe Lys Thr Ala Ile Gin Asp Ala Asp Ile Leu Gin Arg Ile 385 390 395 400 Glu Asn Asp Thr Phe Leu Pro Arg Gin Arg Thr Lys Arg Asn Gly Val 405 410 415 Page 2462 of 3790 Leu Pro Tyr Gin Leu His Leu Ala Glu Leu Glu Gin Ile Ile Lys Lys 420 425 430 Gin Ser Lys Tyr Tyr Pro Phe Leu Ala Asn Ile Tyr Thr Gin Asp Asn 435 440 445 Lys Thr Glu Asn Lys Leu Ile Gly Leu Leu Lys Phe Arg Val Pro Tyr 450 455 460 Tyr Val Gly Pro Leu Val Glu Ala Glu Lys Val Thr Gly Asp Gly Lys 465 470 475 480 Asn His Trp Leu Ile Lys Lys Glu Leu Gin Glu Asn Thr Pro Ile Thr 485 490 495 Pro Phe Asn Phe Asp Asp Val Val Asp Lys Asp Lys Ser Gly Glu Gin 500 505 510 Phe Ile Lys Arg Ile Thr Gly Thr Asp Ser Tyr Leu Ile Gly Glu Pro 515 520 525 Thr Leu Pro Glu Asn Ser Leu Leu Tyr Gin Lys Tyr Asn Val Leu Gin 530 535 540 Glu Leu Asn Asn Val Arg Asn Glu Arg His Gin Arg Leu Pro Ile Lys 545 550 555 560 Val Lys Gin Asp Ile Phe Glu His Val Phe Lys Ile Asp Lys Asn Val 565 570 575 Asn Ala Lys Lys Val Met Ala Tyr Leu Lys Leu Asn Gly Tyr Gly Asp 580 585 590 Phe Gin Ile Ala Gly Leu Ser Asp Thr Arg Thr Gly Lys Phe Asn Ser 595 600 605 Asn Leu Ser Ser Tyr Asn Tyr Phe Val Asp Leu Leu Gly Arg Glu Lys 610 615 620 Thr Glu Lys Ile Arg Glu Asp Arg Leu Glu Glu Ile Ile Glu Ile Gin 625 630 635 640 Thr Val Phe Glu Asp Lys Ile Leu Val Ala Lys Arg Leu Ser Asn Leu 645 650 655 Asp Phe Leu Thr Pro Gin Glu Lys Ser Lys Leu Ser Ala Lys His Tyr 660 665 670 Page 2463 of 3790 Thr Gly Trp Gly Arg Leu Ser Gin Lys Leu Leu Thr Thr Gin Phe Ile 675 680 685 Lys Thr Ala Leu Ser Glu Ala Gly Asp Ile Ile Pro Gin Ser His Ser 690 695 700 Ile Ile Asp Leu Leu Tyr Tyr Thr Asp Lys Asn Leu Met Glu Ile Leu 705 710 715 720 Asn Asp Lys Thr Phe Asn Val Arg Asn Trp Leu Thr Glu Gin Asn Lys 725 730 735 Gly Thr Glu Ser Gly Asn Ser Leu Tyr Asp Gin Ile Asp Ala Leu Ala 740 745 750 Gly Pro Lys Asp Ile Lys Arg Gly Ile Thr Gin Val Phe Ser Ile Ile 755 760 765 Asp Asp Ile Lys Lys Ala Met Gly Ser Asn Pro Glu Thr Val Tyr Leu 770 775 780 Glu Phe Ala Arg Glu Thr Gin Thr Ser Arg Leu Thr Asn Ser Arg Leu 785 790 795 800 Asn Arg Val Gin Glu Ile Tyr Asn Ser Pro Glu Leu Lys Thr Glu Phe 805 810 815 Ala Tyr Leu Ala Lys Lys Leu Glu Ala Glu Thr Lys Glu Ser Ile His 820 825 830 Asp Asp Arg Leu Tyr Leu Tyr Tyr Leu Gin Glu Gly Arg Asp Met Tyr 835 840 845 Thr Gly Lys Glu Ile Pro Phe Asp Gin Ile Ser Ser Asn Tyr Asp Ile 850 855 860 Asp His Ile Ile Pro Gin Ala Phe Thr Lys Asp Asp Ser Leu Asp Asn 865 870 875 880 Arg Val Leu Val Asn Arg Ala Thr Asn Ala Arg Lys Ser Asn Ser Pro 885 890 895 Thr Phe Thr Asn Asp Ile Ile Asp Asn Arg Lys Ser Trp Trp Gin Ser 900 905 910 Leu Val Lys Arg Gly Leu Met Ser Lys Glu Lys Phe Glu Arg Leu Thr Page 2464 of 3790 Page 2465 of 3790 Gly Glu 1355 1054 883 PRT Leuconostoc pseudomesenteroides 1054 Page 2466 of 3790 Met Ile Gly Val Arg Leu Phe Glu Gly Ala Asp Thr Ala Ala Glu Arg 15 10 15 Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg Arg Trp Arg 20 25 30 Leu Arg Leu Leu Asn Asp Ile Phe Ala Ser Glu Leu Ser Lys Ile Asp 35 40 45 Glu Asn Phe Leu Pro Arg Leu Lys Tyr Ser Trp Val Asn Lys Asn Asp 50 55 60 Thr Asp Asn Val His Phe Gly Val Gly Val Phe Asp Asn Ser Glu Gin 65 70 75 80 Glu Lys Ala Phe Tyr Gin Asp Tyr Pro Thr Ile Tyr His Leu Arg Gin 85 90 95 Lys Leu Met Thr Asp Asn Arg Gin His Asp Leu Arg Glu Val Tyr Leu 100 105 110 Ala Ile His His Ile Val Lys Tyr Arg Gly His Phe Leu Asn Ser Gly 115 120 125 Glu Ile Ser Ala Asn Ser Ser Phe Asp Ala Gin Lys Phe Leu Glu Leu 130 135 140 Leu Arg Glu Phe Asp Asn Thr Phe Tyr Pro Asp Ala Val Lys Phe Leu 145 150 155 160 Asn Leu Asp Gin Leu Asp Leu Pro Asp Lys Ile Ser Ser Glu Ile Ser 165 170 175 Asp Ser Lys Ile Ser Lys Ser Glu Arg Val Asp Arg Val Leu Gin His 180 185 190 Val Gin Leu Ala Asn Ser Gly Ala Lys Lys Ile Leu Lys Ala Ile Leu 195 200 205 Asn Ala Val Val Gly Asn Ser Val Asp Ser Val Ala Met Phe Ser Leu 210 215 220 Ser Asp Leu Asp Lys Glu Glu Lys Lys Lys Ile Asn His Pro Val Thr 225 230 235 240 Asp Ser Lys Pro Phe Lys Tyr Ser Asp Lys Glu Val Glu Ala Lys Leu 245 250 255 Page 2467 of 3790 Asp Glu Leu Ser Asn Leu Leu Gin Asp Glu Gin Lys Ile Glu Phe Leu 260 265 270 Ser Leu Leu Lys Leu Ser Phe Asp Gly Leu Thr Leu Lys Met Leu Leu 275 280 285 Gly Asn Ala Lys Ser Val Ser Glu Ala Met Val Glu Arg Tyr Lys Val 290 295 300 His Lys Asp Asp Leu Lys Phe Ile Lys Glu Asn Ile Leu Asn Ser Phe 305 310 315 320 Ser Lys Asp Lys Lys Lys Glu Phe Asp Lys Tyr Tyr Glu Ala His Leu 325 330 335 Ala Glu Lys Asp Val Asp Asn Val Asp Lys Tyr Phe Lys Lys Ile Ile 340 345 350 Asp Asp Ser Ile Ile Ser Lys Asp Lys Lys Ile Glu Leu Leu Gin Lys 355 360 365 Ile Asp Asp His Asp Phe Leu Pro Ser Gin Arg Ser Lys Ile Asn Gly 370 375 380 Ala Ile Pro His Gin Leu His Arg Asn Glu Leu Asp Lys Ile Ile Ser 385 390 395 400 Gin Gin Ser Lys Tyr Tyr Pro Phe Leu Ala Asp Ser Tyr Thr Gin Asn 405 410 415 Gly Lys Thr Glu Thr Lys Leu Ala Gly Leu Val Asn Phe Arg Val Pro 420 425 430 Tyr Tyr Val Gly Pro Leu Val Ser Lys Glu Asn Ala Asp Arg Asn Asn 435 440 445 Pro Asp Gly Gly Gin Asn His Trp Val Glu Phe Lys Glu Asn Thr Ser 450 455 460 Leu Ser Asn Leu Thr Pro Trp Asn Phe Asn Glu Ile Val Asp Lys Asp 465 470 475 480 Lys Ser Ala Ala Lys Phe Ile Glu Arg Leu Thr Gly Met Asp Thr Tyr 485 490 495 Leu Ile Gly Glu Pro Thr Leu Pro Gin Asn Ser Leu Leu Tyr Gin Lys 500 505 510 Page 2468 of 3790 Tyr Asn Val Leu Gin Glu Leu Asn Asn Ile Arg Val Asp Asn His Lys 515 520 525 Leu Asp Val Lys Ile Lys Gin Asp Val Phe Glu His Leu Phe Lys Thr 530 535 540 Gin Asn Ser Val Ser Ala Lys Asp Val Lys Asn Tyr Leu Ile Ala Asn 545 550 555 560 Gly Tyr Ala Ala Pro Ser Ile Gin Ile Thr Gly Leu Ser Asp Thr Asn 565 570 575 Glu Lys Thr Phe Asn Ser Lys Leu Ser Ser Tyr Asn Tyr Leu Val Asp 580 585 590 Lys Leu Gly Arg Thr Phe Val Glu Ser Val Lys Ser Asp Val Leu Glu 595 600 605 Lys Ile Ile Glu Leu Gin Thr Val Phe Glu Asp Lys Thr Val Leu Leu 610 615 620 Arg Gin Leu Ser Met Ile Ser Glu Leu Thr Leu Ala Gin Ala Asn Gin 625 630 635 640 Leu Ala Glu Lys His Trp Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu 645 650 655 Leu Ser Ser Lys Val Val Asp Val Asn Lys Ile Thr Asn Ser Thr Phe 660 665 670 Tyr Pro Ala Thr Ser Arg Gin Thr Ile Ile Asp Thr Leu Tyr His Thr 675 680 685 Gin Leu Asn Leu Met Glu Ile Ile Asn Asn Ala Glu Asp Leu Tyr Gly 690 695 700 Val Arg Gin Trp Ile Ser Glu Gin Asn Lys Ser Asp Ser Ser Asp Thr 705 710 715 720 Asn Asp Val Tyr Asp Gin Ile Gin Glu Leu Ala Gly Asp Lys Lys Ile 725 730 735 Lys Arg Gly Ile Thr Gin Ser Phe Arg Ile Leu Asp Asp Ile Val Lys 740 745 750 Ala Met Gly Gly Glu Pro Glu Arg Val Tyr Leu Glu Phe Ala Arg Glu Page 2469 of 3790 Ser Lys Lys 1055 468 PRT Leuconostoc pseudomesenteroides Asn Asp Tyr His His Ala His Asp Ala Leu Phe Val Ala Thr Val Gly Page 2471 of 3790 Page 2472 of 3790 Ile Thr Val Ala Glu Thr Glu Thr Asn Ala Lys Leu Ser Ala Ser Met 85 90 95 Ile Glu Arg Phe Asp Thr His Glu Glu Asp Leu Gly Glu Leu Lys Ala 100 105 110 Phe Ile Lys Leu His Leu Pro Lys His Tyr Glu Glu Ile Phe Ser Asn 115 120 125 Thr Glu Lys His Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Lys Gin 130 135 140 Ala Asp Phe Tyr Lys Tyr Met Lys Thr Thr Leu Glu Asn Ile Glu Gly 145 150 155 160 Ala Asp Tyr Phe Ile Ala Lys Ile Glu Lys Glu Asn Phe Leu Arg Lys 165 170 175 Gin Arg Thr Phe Asp Asn Gly Ala Ile Pro His Gin Leu His Leu Glu 180 185 190 Glu Leu Glu Ala Ile Leu His Gin Gin Ala Lys Tyr Tyr Pro Phe Leu 195 200 205 Lys Glu Asn Tyr Asp Lys Ile Lys Ser Leu Val Thr Phe Arg Ile Pro 210 215 220 Tyr Phe Val Gly Pro Leu Ala Asn Gly Gin Ser Glu Phe Ala Trp Leu 225 230 235 240 Thr Arg Lys Ala Asp Gly Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys 245 250 255 Val Asp Phe Gly Lys Ser Ala Val Asp Phe Ile Glu Lys Met Thr Asn 260 265 270 Lys Asp Thr Tyr Leu Pro Lys Glu Asn Val Leu Pro Lys His Ser Leu 275 280 285 Cys Tyr Gin Lys Tyr Leu Val Tyr Asn Glu Leu Thr Lys Val Arg Tyr 290 295 300 Ile Asn Asp Gin Gly Lys Thr Ser Tyr Phe Ser Gly Gin Glu Lys Glu 305 310 315 320 Gin Ile Phe Asn Asp Leu Phe Lys Gin Lys Arg Lys Val Lys Lys Lys 325 330 335 Page 2473 of 3790 Asp Leu Glu Leu Phe Leu Arg Asn Met Ser His Val Glu Ser Pro Thr 340 345 350 Ile Glu Gly Leu Glu Asp Ser Phe Asn Ser Ser Tyr Ser Thr Tyr His 355 360 365 Asp Leu Leu Lys Val Gly Ile Lys Gin Glu Ile Leu Asp Asn Pro Val 370 375 380 Asn Thr Glu Met Leu Glu Asn Ile Val Lys Ile Leu Thr Val Phe Glu 385 390 395 400 Asp Lys Arg Met Ile Lys Glu Gin Leu Gin Gin Phe Ser Asp Val Leu 405 410 415 Asp Gly Val Val Leu Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp 420 425 430 Gly Arg Leu Ser Ala Lys Leu Leu Met Gly Ile Arg Asp Lys Gin Ser 435 440 445 His Leu Thr Ile Leu Asp Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg 450 455 460 Asn Leu Met Gin Leu Ile Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile 465 470 475 480 Ile Glu Lys Glu Gin Val Thr Thr Ala Asp Lys Asp Ile Gin Ser Ile 485 490 495 Val Ala Asp Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin 500 505 510 Ser Leu Lys Ile Val Asp Glu Leu Val Ser Val Met Gly Tyr Pro Pro 515 520 525 Gin Thr Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Lys 530 535 540 Gly Lys Asn Asn Ser Arg Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile 545 550 555 560 Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro Thr Asp Asn Gin 565 570 575 Glu Leu Lys Asn Asn Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys 580 585 590 Page 2474 of 3790 Asp Met Tyr Thr Gly Gin Asp Leu Asp Ile His Asn Leu Ser Asn Tyr 595 600 605 Asp Ile Asp His Ile Val Pro Gin Ser Phe Ile Thr Asp Asn Ser Ile 610 615 620 Asp Asn Leu Val Leu Thr Ser Ser Ala Gly Asn Arg Glu Lys Gly Asn 625 630 635 640 Asp Val Pro Pro Leu Glu Ile Val Gin Lys Arg Lys Val Phe Trp Glu 645 650 655 Lys Leu Tyr Gin Gly Asn Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu 660 665 670 Thr Lys Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Arg Phe 675 680 685 Ile His Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys Asn Val Ala 690 695 700 Asn Ile Leu His Gin Arg Phe Asn Tyr Gly Lys Asp Asp His Gly Asn 705 710 715 720 Thr Met Lys Gin Val Arg Ile Val Thr Leu Lys Ser Ala Leu Val Ser 725 730 735 Gin Phe Arg Lys Gin Phe Gin Leu Tyr Lys Val Arg Gly Val Asn Asp 740 745 750 Tyr His His Ala His Asp Ala Tyr Leu Asn Gly Val Val Ala Asn Thr 755 760 765 Leu Leu Lys Val Tyr Pro Gin Leu Glu Pro Glu Phe Val Tyr Gly Asp 770 775 780 Tyr His Gin Phe Asp Trp Phe Lys Ala Asn Lys Ala Thr Ala Lys Lys 785 790 795 800 Gin Phe Tyr Thr Asn Ile Met Leu Phe Phe Ala Gin Lys Asp Arg Ile 805 810 815 Ile Asp Glu Asn Gly Glu Ile Leu Trp Asp Lys Lys Tyr Leu Asp Thr 820 825 830 Val Lys Lys Val Met Ser Tyr Arg Gin Met Asn Ile Val Lys Lys Thr Page 2475 of 3790 Page 2476 of 3790 Ser Thr Ile Ile Tyr Gin Ser Ile Thr Gly Leu Tyr Glu Ser Arg 1085 1090 1095 Lys Arg Leu Asp Asp 1100 1057 1337 PRT Listeria innocua 1057 Page 2477 of 3790 Gin Thr Tyr Asn Gin Val Phe Ala Ser Gly Ile Glu Asp Gly Ser Leu 195 200 205 Lys Lys Leu Glu Asp Asn Lys Asp Val Ala Lys Ile Leu Val Glu Lys 210 215 220 Val Thr Arg Lys Glu Lys Leu Glu Arg Ile Leu Lys Leu Tyr Pro Gly 225 230 235 240 Glu Lys Ser Ala Gly Met Phe Ala Gin Phe Ile Ser Leu Ile Val Gly 245 250 255 Ser Lys Gly Asn Phe Gin Lys Pro Phe Asp Leu Ile Glu Lys Ser Asp 260 265 270 Ile Glu Cys Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ser Leu Leu 275 280 285 Ala Leu Ile Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn 290 295 300 Ala Tyr Ser Ala Val Val Leu Ser Ser Ile Ile Thr Val Ala Glu Thr 305 310 315 320 Glu Thr Asn Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Thr 325 330 335 His Glu Glu Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu 340 345 350 Pro Lys His Tyr Glu Glu Ile Phe Ser Asn Thr Glu Lys His Gly Tyr 355 360 365 Ala Gly Tyr Ile Asp Gly Lys Thr Lys Gin Ala Asp Phe Tyr Lys Tyr 370 375 380 Met Lys Met Thr Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala 385 390 395 400 Lys Ile Glu Lys Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn 405 410 415 Gly Ala Ile Pro His Gin Leu His Leu Glu Glu Leu Glu Ala Ile Leu 420 425 430 His Gin Gin Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Asn Tyr Asp Lys 435 440 445 Page 2478 of 3790 Ile Lys Ser Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu 450 455 460 Ala Asn Gly Gin Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly 465 470 475 480 Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser 485 490 495 Ala Val Asp Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro 500 505 510 Lys Glu Asn Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Leu 515 520 525 Val Tyr Asn Glu Leu Thr Lys Val Arg Tyr Ile Asn Asp Gin Gly Lys 530 535 540 Thr Ser Tyr Phe Ser Gly Gin Glu Lys Glu Gin Ile Phe Asn Asp Leu 545 550 555 560 Phe Lys Gin Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu 565 570 575 Arg Asn Met Ser His Val Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp 580 585 590 Ser Phe Asn Ser Ser Tyr Ser Thr Tyr His Asp Leu Leu Lys Val Gly 595 600 605 Ile Lys Gin Glu Ile Leu Asp Asn Pro Val Asn Thr Glu Met Leu Glu 610 615 620 Asn Ile Val Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys 625 630 635 640 Glu Gin Leu Gin Gin Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys 645 650 655 Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys 660 665 670 Leu Leu Met Gly Ile Arg Asp Lys Gin Ser His Leu Thr Ile Leu Asp 675 680 685 Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gin Leu Ile 690 695 700 Page 2479 of 3790 Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin Val 705 710 715 720 Thr Thr Ala Asp Lys Asp Ile Gin Ser Ile Val Ala Asp Leu Ala Gly 725 730 735 Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp 740 745 750 Glu Leu Val Ser Val Met Gly Tyr Pro Pro Gin Thr Ile Val Val Glu 755 760 765 Met Ala Arg Glu Asn Gin Thr Thr Gly Lys Gly Lys Asn Asn Ser Arg 770 775 780 Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gin 785 790 795 800 Ile Leu Lys Glu His Pro Thr Asp Asn Gin Glu Leu Arg Asn Asn Arg 805 810 815 Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Gin 820 825 830 Asp Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val 835 840 845 Pro Gin Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Leu Val Leu Thr 850 855 860 Ser Ser Ala Gly Asn Arg Glu Lys Gly Asp Asp Val Pro Pro Leu Glu 865 870 875 880 Ile Val Arg Lys Arg Lys Val Phe Trp Glu Lys Leu Tyr Gin Gly Asn 885 890 895 Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly 900 905 910 Gly Leu Thr Glu Ala Asp Lys 915 Ala Arg Phe 920 Ile His Arg Gin 925 Leu Val Glu Thr Arg Gin 930 Ile Thr Lys 935 Asn Val Ala Asn Ile Leu His Gin Arg 940 Phe Asn Tyr Glu Lys Asp Asp His Gly Asn Thr Met Lys Gin Val Arg 960 945 950 Page 2480 of 3790 955 1058 953 PRT Listeria ivanovii 1058 Met Lys Lys Met Leu Ala Asn Ile Asp Gly Ala Asp Tyr Phe Ile Asp 15 10 15 Gin Ile Glu Glu 20 Glu Asn Phe Leu Arg Lys 25 Gin Arg Thr Phe Asp Asn 30 Gly Thr Ile Pro His 35 Gin Leu His 40 Leu Glu Glu Leu Glu Ala Ile Leu His Gin Gin Ala Lys Tyr Tyr Pro Phe Leu Arg Lys Asp Tyr Glu Lys 50 55 60 Page 2482 of 3790 Ile Arg Ser Leu Val Thr Phe Arg Ile Pro Tyr Phe Ile Gly Pro Leu 65 70 75 80 Ala Asn Gly Gin Ser Asp Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly 85 90 95 Glu Ile Arg Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser 100 105 110 Ala Ile Asp Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro 115 120 125 Lys Glu Asn Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Met 130 135 140 Val Tyr Asn Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gin Gly Lys 145 150 155 160 Thr His His Phe Ser Gly Gin Glu Lys Gin Gin Ile Phe Asn Gly Leu 165 170 175 Phe Lys Gin Gin Arg Lys Val Lys Lys Lys Asp Leu Glu Arg Phe Leu 180 185 190 Tyr Thr Ile Asn His Ile Glu Ser Pro Thr Ile Glu Gly Val Glu Asp 195 200 205 Ala Phe Asn Ser Ser Phe Ala Thr Tyr His Asp Leu Gin Lys Gly Gly 210 215 220 Val Thr Gin Glu Ile Leu Asp Asn Pro Leu Asn Ala Asp Met Leu Glu 225 230 235 240 Glu Ile Val Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys 245 250 255 Glu Gin Leu Gin Ser Phe Ser Asp Val Leu Asp Gly Thr Ile Leu Lys 260 265 270 Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys 275 280 285 Leu Leu Thr Gly Ile Arg Asp Lys His Ser His Leu Thr Ile Leu Asp 290 295 300 Tyr Leu Met Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gin Leu Ile 305 310 315 320 Page 2483 of 3790 Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin Val 325 330 335 Ser Thr Ala Asp Lys Gly Ile Gin Ser Ile Val Ala Glu Leu Ala Gly 340 345 350 Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp 355 360 365 Glu Leu Val Gly Ile Met Gly Tyr Pro Pro Gin Thr Ile Val Val Glu 370 375 380 Met Ala Arg Glu Asn Gin Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys 385 390 395 400 Pro Arg Phe Ile Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gin 405 410 415 Ile Leu Lys Glu His Pro Thr Asp Asn Gin Cys Leu Lys Asn Asp Arg 420 425 430 Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Lys 435 440 445 Glu Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Ile 450 455 460 Pro Gin Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Arg Val Leu Val 465 470 475 480 Ser Ser Thr Ala Asn Arg Glu Lys Gly Asp Asn Val Pro Leu Leu Glu 485 490 495 Val Val Arg Lys Arg Lys Ala Phe Trp Glu Lys Leu Tyr Gin Ala Lys 500 505 510 Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly 515 520 525 Gly Leu Thr Glu Ala Asp Lys Ala Asn Phe Ile Gin Arg Gin Leu Val 530 535 540 Glu Thr Arg Gin Ile Thr Lys Asn Val Ala Asn Ile Leu Tyr Gin Arg 545 550 555 560 Phe Asn Cys Lys Gin Asp Glu Asn Gly Asn Glu Val Glu Gin Val Arg 565 570 575 Page 2484 of 3790 Ile Val Thr Leu Lys Ser Thr Leu Val Ser Gin Phe Arg Lys Gin Phe 580 585 590 Gin Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr His His Ala His Asp 595 600 605 Ala Tyr Leu Asn Gly Val Val Ala Asn Thr Leu Leu Lys Val Tyr Pro 610 615 620 Gin Leu Glu Pro Glu Phe Val Tyr Gly Asp Tyr His Gin Phe Asp Trp 625 630 635 640 Phe Lys Ala Asn Lys Ala Thr Ala Lys Lys Gin Phe Tyr Thr Asn Ile 645 650 655 Met Arg Phe Phe Ala Lys Glu Asn Gin Ile Ile Asp Lys Asn Gly Glu 660 665 670 Ile Leu Trp Asp Asn Arg Tyr Leu Asp Thr Ile Lys Lys Val Leu Ser 675 680 685 Tyr Arg Gin Met Asn Ile Val Lys Lys Thr Glu Ile Gin Lys Gly Glu 690 695 700 Phe Ser Asn Ala Thr Val Asn Pro Lys Gly Asn Ser Ser Lys Leu Ile 705 710 715 720 Ser Arg Lys Ala Asp Trp Asn Pro Ile Lys Tyr Gly Gly Phe Asp Gly 725 730 735 Ser Asn Met Ala Tyr Ser Ile Val Ile Glu Tyr Glu Lys Arg Lys Lys 740 745 750 Lys Thr Val Ile Lys Lys Glu Leu Ile Gin Ile Asn Ile Met Glu Arg 755 760 765 Val Ala Phe Glu Lys Asp Gin Lys Ala Phe Leu Glu Glu Lys Gly Tyr 770 775 780 Tyr Ser Pro Lys Val Leu Thr Lys Ile Pro Lys Tyr Thr Leu Tyr Glu 785 790 795 800 Cys Glu Asn Gly Arg Arg Arg Met Leu Gly Ser Ala Asn Glu Ala Gin 805 810 815 Lys Gly Asn Gin Met Val Leu Pro Asn His Leu Met Thr Leu Leu Tyr 945 950 1059 232 PRT Ile Asn Lys Phe Asn Pro Tyr Gin Ala Arg Tyr Asn Ala Ile Phe Gly Page 2486 of 3790 90 225 230 1060 300 PRT Listeria monocytogenes 1060 Ile Met Gly Tyr Pro Pro Gin Thr Ile Val Val Glu Met Ala Arg Glu 1061 782 PRT Listeria monocytogenes Page 2488 of 3790 misc_feature (722)..(722) Xaa can be any naturally occurring amino acid 1061 Page 2489 of 3790 Lys Asn Asn Ser Arg Pro Arg Tyr Lys Ser Leu Glu Lys Ala Ile Lys 225 230 235 240 Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro Thr Asp Asn Gin Glu 245 250 255 Leu Lys Asn Asn Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys Asp 260 265 270 Ile Tyr Thr Gly Gin Glu Leu Asp Ile His Asn Leu Ser Asn Tyr Asp 275 280 285 Ile Asp His Ile Val Pro Gin Ser Phe Ile Thr Asp Asn Ser Ile Asp 290 295 300 Asn Leu Val Leu Thr Ser Ser Ala Gly Asn Arg Glu Lys Gly Asp Asp 305 310 315 320 Val Pro Pro Leu Glu Ile Val Arg Lys Arg Lys Val Phe Trp Glu Lys 325 330 335 Leu Tyr Gin Gly Asn Leu Met Ser Lys Arg Lys Phe Asp Tyr Leu Thr 340 345 350 Lys Ala Glu Arg Gly Gly Leu Thr Glu Ala Asp Lys Ala Arg Phe Ile 355 360 365 His Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys Asn Val Ala Asn 370 375 380 Ile Leu His Gin Arg Phe Asn Asn Glu Thr Asp Asn His Gly Asn Thr 385 390 395 400 Met Glu Gin Val Arg Ile Val Thr Leu Lys Ser Ala Leu Val Ser Gin 405 410 415 Phe Arg Lys Gin Phe Gin Leu Tyr Lys Val Arg Glu Val Asn Asp Tyr 420 425 430 His His Ala His Asp Ala Tyr Leu Asn Gly Val Val Ala Asn Thr Leu 435 440 445 Leu Lys Val Tyr Pro Gin Leu Glu Pro Glu Phe Val Tyr Gly Glu Tyr 450 455 460 His Gin Phe Asp Trp Phe Lys Ala Asn Lys Ala Thr Ala Lys Lys Gin Page 2491 of 3790 Page 2492 of 3790 Ile Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Ala Leu Asp Thr 165 170 175 Lys Asn Thr Ser Ile Asp Glu Met Phe Lys Gin Phe Leu Gin Ile Tyr 180 185 190 Asn Gin Val Phe Ala Asn Asp Ile Glu Glu Ala Ser Leu Lys Lys Thr 195 200 205 Glu Lys Asn Gin Glu Val Ala Gin Ile Leu Ala Glu Lys Phe Thr Arg 210 215 220 Lys Asp Lys Leu Asp Lys Ile Leu Ser Leu Tyr Pro Gly Glu Lys Thr 225 230 235 240 Thr Gly Val Phe Ala Gin Phe Val Asn Ile Ile Val Gly Ser Thr Gly 245 250 255 Lys Phe Lys Lys His Phe Asn Leu His Glu Lys Lys Asp Ile Asn Cys 260 265 270 Ala Glu Asp Thr Tyr Asp Thr Asp Leu Glu Ser Leu Leu Ala Ile Ile 275 280 285 Gly Asp Glu Phe Ala Glu Val Phe Val Ala Ala Lys Asn Ala Tyr Asn 290 295 300 Ala Val Val Leu Ser Asn Ile Ile Thr Val Thr Asp Ser Thr Thr Arg 305 310 315 320 Ala Lys Leu Ser Ala Ser Leu Ile Glu Arg Phe Glu Asn His Lys Glu 325 330 335 Asp Leu Lys Lys Met Lys Arg Phe Val Arg Thr Tyr Leu Pro Glu Lys 340 345 350 Tyr Asp Glu Ile Phe Asp Asp Thr Glu Lys His Gly Tyr Ala Gly Tyr 355 360 365 Ile Ser Gly Lys Thr Lys Gin Ala Asp Phe Tyr Lys Tyr Met Lys Ala 370 375 380 Thr Leu Glu Lys Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 385 390 395 400 Glu Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile 405 410 415 Page 2493 of 3790 Pro His Gin Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gin Gin 420 425 430 Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 435 440 445 Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 450 455 460 Gin Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 465 470 475 480 Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 485 490 495 Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 500 505 510 Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Met Val Tyr Asn 515 520 525 Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gin Gly Lys Thr Asn Tyr 530 535 540 Phe Ser Gly Gin Glu Lys Gin Gin Ile Phe Asn Asp Leu Phe Lys Gin 545 550 555 560 Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 565 570 575 Asn Gin Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 580 585 590 Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gin 595 600 605 Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 610 615 620 Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gin Leu 625 630 635 640 Gin Gin Phe Ser Asp Val Leu Asp Gly Thr Val Leu Lys Lys Leu Glu 645 650 655 Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 660 665 670 Page 2494 of 3790 Gly Ile Arg Asp Lys Gin Ser His Leu Thr Ile Leu Asp Tyr Leu Met 675 680 685 Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gin Leu Ile Asn Asp Ser 690 695 700 Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin Val Ser Thr Thr 705 710 715 720 Asp Lys Asp Leu Gin Ser Ile Val Ala Glu Leu Ala Gly Ser Pro Ala 725 730 735 Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val 740 745 750 Ser Val Met Gly Tyr Pro Pro Gin Thr Ile Val Val Glu Met Ala Arg 755 760 765 Glu Asn Gin Thr Thr Asn Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 770 775 780 Lys Ser Leu Glu Lys Ala Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys 785 790 795 800 Glu His Pro Thr Asp Asn Gin Glu Leu Lys Asn Asn Arg Leu Tyr Leu 805 810 815 Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Gin Glu Leu Asp 820 825 830 Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Ile Val Pro Gin Ser 835 840 845 Phe Ile Thr Asp Asn Ser Val Asp Asn Leu Val Leu Thr Ser Ser Ala 850 855 860 Gly Asn Arg Glu Lys Gly Asp Asn Val Pro Pro Leu Glu Ile Val Gin 865 870 875 880 Lys Arg Lys Ile Phe Trp Glu Lys Leu Tyr Gin Gly Asn Leu Met Ser 885 890 895 Lys Arg Lys Phe Asp Tyr Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr 900 905 910 Glu Ala Asp Lys Ala Arg Phe Ile His Arg Gin Leu Val Glu Thr Arg Page 2495 of 3790 1063 1334 PRT Listeria monocytogenes 1063 Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Leu Thr Asp Gin Tyr Asp Leu Val Lys Arg Lys Met 20 25 30 Page 2497 of 3790 Lys Val Ala Gly Asn Ser Asp Lys Lys Gin Ile Lys Lys Asn Phe Trp 35 40 45 Gly Val Arg Leu Phe Asp Asp Gly Gin Thr Ala Val Asp Arg Arg Met 50 55 60 Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 85 90 95 Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 100 105 110 Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 115 120 125 His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 130 135 140 Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 165 170 175 Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gin Phe Ile Gin Thr Tyr 180 185 190 Asn Gin Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 195 200 205 Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 210 215 220 Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 225 230 235 240 Thr Gly Met Phe Ala Gin Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 245 250 255 Asn Phe Gin Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 260 265 270 Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 275 280 285 Page 2498 of 3790 Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 290 295 300 Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 305 310 315 320 Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 325 330 335 Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gin 340 345 350 Tyr Gin Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Asp Gly Lys Thr Lys Gin Val Asp Phe Tyr Lys Tyr Leu Lys Thr 370 375 380 Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 385 390 395 400 Glu Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile 405 410 415 Pro His Gin Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gin Gin 420 425 430 Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 435 440 445 Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 450 455 460 Gin Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 465 470 475 480 Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 485 490 495 Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 500 505 510 Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Met Val Tyr Asn 515 520 525 Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gin Gly Lys Thr Asn Tyr 530 535 540 Page 2499 of 3790 Phe Ser Gly Arg Glu Lys Gin Gin Ile Phe Asn Asp Leu Phe Lys Gin 545 550 555 560 Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 565 570 575 Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 580 585 590 Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Leu Lys Gin 595 600 605 Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Ile Leu Glu Asp Ile Val 610 615 620 Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gin Leu 625 630 635 640 Glu Gin Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 645 650 655 Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 660 665 670 Gly Ile Arg Asp Lys Gin Ser His Leu Thr Ile Leu Asp Tyr Leu Met 675 680 685 Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gin Leu Ile Asn Asp Ser 690 695 700 Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin Val Ser Thr Thr 705 710 715 720 Asp Lys Asp Leu Gin Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 725 730 735 Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val 740 745 750 Ser Ile Met Gly Tyr Pro Pro Gin Thr Ile Val Val Glu Met Ala Arg 755 760 765 Glu Asn Gin Thr Thr Gly Lys Gly Lys Asn Asn Ser Lys Pro Arg Tyr 770 775 780 Lys Ser Leu Glu Lys Ala Ile Lys Asp Phe Gly Ser Gin Ile Leu Lys 800 785 790 Page 2500 of 3790 795 Page 2501 of 3790 Page 2502 of 3790 Asn Ala Met Gly Ala Pro Ala Ser 1290 Asp Arg Lys Arg Tyr Thr Asn 1305 Ile Ile Tyr Gin Ser Ile Thr 1320 Leu Asp Asp Leu Asp Ile Gly Thr Asn Ser Val 10 15 Gly Trp Ala Val Leu Thr Asp Gin 20 Tyr Asp Leu Val Lys Arg Lys Met 25 30 Lys Val Ala Gly Asn Ser Asp Lys 35 40 Lys Gin Ile Lys Lys Asn Phe Trp 45 Gly Val Arg Leu Phe Asp Asp Gly 50 55 Gin Thr Ala Val Asp Arg Arg Met 60 Asn Arg Thr Ala Arg Arg Arg Ile 65 70 Glu Arg Arg Arg Asn Arg Ile Ser 75 80 Tyr Leu Gin Glu Ile Phe Ala Val 85 Glu Met Ala Asn Ile Asp Ala Asn 90 95 Phe Phe Cys Arg Leu Asn Asp Ser 100 Phe Tyr Val Asp Ser Glu Lys Arg 105 110 Asn Ser Arg His Pro Phe Phe Ala 115 120 Thr Ile Glu Glu Glu Val Ala Tyr 125 His Lys Asn Tyr Arg Thr Ile Tyr 130 135 His Leu Arg Glu Glu Leu Val Asn 140 Ser Ser Glu Lys Ala Asp Leu Arg 145 150 Leu Val Tyr Leu Ala Leu Ala His 155 160 Page 2503 of 3790 Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 165 170 175 Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gin Phe Ile Gin Thr Tyr 180 185 190 Asn Gin Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 195 200 205 Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 210 215 220 Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 225 230 235 240 Thr Gly Met Phe Ala Gin Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 245 250 255 Asn Phe Gin Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 260 265 270 Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 275 280 285 Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 290 295 300 Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 305 310 315 320 Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 325 330 335 Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gin 340 345 350 Tyr Gin Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Asp Gly Lys Thr Lys Gin Val Asp Phe Tyr Lys Tyr Leu Lys Thr 370 375 380 Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 385 390 395 400 Glu Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile 405 410 415 Page 2504 of 3790 Pro His Gin Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gin Gin 420 425 430 Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 435 440 445 Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 450 455 460 Gin Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 465 470 475 480 Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 485 490 495 Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 500 505 510 Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Met Val Tyr Asn 515 520 525 Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gin Gly Lys Thr Asn Tyr 530 535 540 Phe Ser Gly Arg Glu Lys Gin Gin Ile Phe Asn Asp Leu Phe Lys Gin 545 550 555 560 Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 565 570 575 Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 580 585 590 Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Leu Lys Gin 595 600 605 Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Ile Leu Glu Asp Ile Val 610 615 620 Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gin Leu 625 630 635 640 Glu Gin Phe Ser Asp Val Leu Asp Gly Val Val Leu Lys Lys Leu Glu 645 650 655 Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val Page 2506 of 3790 Page 2507 of 3790 1065 1099 PRT Listeria monocytogenes 1065 Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Leu Thr Asp Gin Tyr Asp Leu Val Lys Arg Lys Met 20 25 30 Page 2508 of 3790 Lys Val Ala Gly Asn Ser Asp Lys Lys Gin Ile Lys Lys Asn Phe Trp 35 40 45 Gly Val Arg Leu Phe Asp Asp Gly Gin Thr Ala Val Asp Arg Arg Met 50 55 60 Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 85 90 95 Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 100 105 110 Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 115 120 125 His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 130 135 140 Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 165 170 175 Lys Asn Thr Ser Val Asp Glu Val Tyr Lys Gin Phe Ile Gin Thr Tyr 180 185 190 Asn Gin Val Phe Met Ser Asn Ile Glu Glu Gly Ala Leu Ala Lys Val 195 200 205 Glu Glu Asn Thr Glu Val Ala Ser Ile Leu Ala Gly Lys Phe Thr Arg 210 215 220 Arg Glu Lys Phe Glu Arg Ile Leu Arg Leu Tyr Pro Gly Glu Lys Ser 225 230 235 240 Thr Gly Met Phe Ala Gin Phe Ile Ser Leu Ile Val Gly Asn Lys Gly 245 250 255 Asn Phe Gin Lys Val Phe Asn Leu Val Glu Lys Thr Asp Ile Glu Cys 260 265 270 Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 275 280 285 Page 2509 of 3790 Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 290 295 300 Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 305 310 315 320 Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 325 330 335 Glu Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gin 340 345 350 Tyr Gin Glu Ile Phe Asn Asn Ala Glu Ile Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Asp Gly Lys Thr Lys Gin Val Asp Phe Tyr Lys Tyr Leu Lys Thr 370 375 380 Thr Leu Glu Asn Val Glu Gly Ala Asp Tyr Phe Ile Thr Lys Ile Glu 385 390 395 400 Glu Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Val Ile 405 410 415 Pro His Gin Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gin Gin 420 425 430 Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Gly Tyr Asp Lys Ile Lys Ser 435 440 445 Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 450 455 460 Gin Ser Glu Phe Ala Trp Leu Thr Arg Lys Asp Asp Gly Glu Ile Arg 465 470 475 480 Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 485 490 495 Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 500 505 510 Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Met Val Tyr Asn 515 520 525 Glu Leu Thr Lys Ile Arg Tyr Ile Asp Asp Gin Gly Lys Thr Asn Tyr Page 2511 of 3790 Page 2512 of 3790 Asn 1066 1334 PRT Listeria monocytogenes 1066 Page 2513 of 3790 Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 165 170 175 Lys Asn Thr Ser Val Asp Gly Val Tyr Lys Gin Phe Ile Gin Thr Tyr 180 185 190 Asn Gin Val Phe Ile Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Met 195 200 205 Glu Glu Asn Thr Thr Val Ala Asp Ile Leu Ala Gly Lys Phe Thr Arg 210 215 220 Lys Glu Lys Leu Glu Arg Ile Leu Gin Leu Tyr Pro Gly Glu Lys Ser 225 230 235 240 Thr Gly Met Phe Ala Gin Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 245 250 255 Asn Phe Gin Lys Val Phe Asp Leu Val Glu Lys Thr Asp Ile Glu Cys 260 265 270 Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 275 280 285 Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 290 295 300 Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Asp Thr Glu Thr Asn 305 310 315 320 Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 325 330 335 Asp Leu Ser Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gin 340 345 350 Tyr Glu Glu Ile Phe Ser Asn Val Ala Ile Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Asp Gly Lys Thr Lys Gin Val Asp Phe Tyr Lys Tyr Leu Lys Thr 370 375 380 Leu Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 385 390 395 400 Page 2514 of 3790 Glu Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Ala Ile 405 410 415 Pro His Gin Leu His Leu Glu Glu Leu Glu Ala Ile Leu His Gin Gin 420 425 430 Ala Lys Tyr Tyr Pro Phe Leu Lys Glu Ala Tyr Asp Lys Ile Lys Ser 435 440 445 Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Asn Gly 450 455 460 Gin Ser Asp Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 465 470 475 480 Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 485 490 495 Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 500 505 510 Val Leu Pro Lys His Ser Leu Tyr Tyr Gin Lys Tyr Met Val Tyr Asn 515 520 525 Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gin Gly Lys Thr Asn Tyr 530 535 540 Phe Ser Gly Gin Glu Lys Gin Gin Ile Phe Asn Asp Tyr Phe Lys Gin 545 550 555 560 Lys Arg Lys Val Ser Lys Lys Asp Leu Glu Gin Phe Leu Arg Asn Met 565 570 575 Ser His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 580 585 590 Ser Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Ile Lys Gin 595 600 605 Glu Val Leu Glu Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 610 615 620 Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile Lys Glu Gin Leu 625 630 635 640 Gin Gin Phe Ser Asp Val Leu Asp Gly Ala Val Leu Lys Lys Leu Glu Page 2516 of 3790 Ala Lys Gly Lys Lys Lys Val Val Phe Glu Lys Lys Ile Ile Arg 1130 1135 1140 Page 2517 of 3790 1067 1334 PRT Listeria monocytogenes 1067 Met Lys Asn Pro Tyr Thr Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 2518 of 3790 Gly Trp Ala Val Leu Thr Asn Gin Tyr Asp Leu Val Lys Arg Lys Met 20 25 30 Lys Val Ala Gly Asn Ser Asp Lys Lys Gin Ile Lys Lys Asn Phe Trp 35 40 45 Gly Val Arg Leu Phe Asp Asp Gly Gin Thr Ala Val Asp Arg Arg Met 50 55 60 Asn Arg Thr Ala Arg Arg Arg Ile Glu Arg Arg Arg Asn Arg Ile Ser 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Val Glu Met Ala Asn Ile Asp Ala Asn 85 90 95 Phe Phe Cys Arg Leu Asn Asp Ser Phe Tyr Val Asp Ser Glu Lys Arg 100 105 110 Asn Ser Arg His Pro Phe Phe Ala Thr Ile Glu Glu Glu Val Ala Tyr 115 120 125 His Lys Asn Tyr Arg Thr Ile Tyr His Leu Arg Glu Glu Leu Val Asn 130 135 140 Ser Ser Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Tyr Arg Gly Asn Phe Leu Ile Glu Gly Ala Leu Asp Thr 165 170 175 Lys Asn Thr Ser Val Asp Gly Val Tyr Glu Gin Phe Ile Gin Thr Tyr 180 185 190 Asn Gin Val Phe Met Ser Asn Ile Glu Glu Gly Thr Leu Ala Lys Val 195 200 205 Glu Glu Asn Ile Glu Val Ala Asn Ile Leu Ala Gly Lys Phe Thr Arg 210 215 220 Arg Glu Lys Phe Glu Arg Ile Leu Gin Leu Tyr Pro Gly Glu Lys Ser 225 230 235 240 Thr Gly Met Phe Ala Gin Phe Ile Ser Leu Ile Val Gly Ser Lys Gly 245 250 255 Asn Phe Gin Lys Val Phe Asp Leu Ile Glu Lys Thr Asp Ile Glu Cys 260 265 270 Page 2519 of 3790 Ala Lys Asp Ser Tyr Glu Glu Asp Leu Glu Ala Leu Leu Ala Ile Ile 275 280 285 Gly Asp Glu Tyr Ala Glu Leu Phe Val Ala Ala Lys Asn Thr Tyr Asn 290 295 300 Ala Val Val Leu Ser Ser Ile Ile Thr Val Thr Ala Thr Glu Thr Asn 305 310 315 320 Ala Lys Leu Ser Ala Ser Met Ile Glu Arg Phe Asp Ala His Glu Lys 325 330 335 Asp Leu Gly Glu Leu Lys Ala Phe Ile Lys Leu His Leu Pro Lys Gin 340 345 350 Tyr Gin Glu Ile Phe Asn Asn Ala Ala Ile Asp Gly Tyr Ala Gly Tyr 355 360 365 Ile Asp Gly Lys Thr Lys Gin Val Asp Phe Tyr Lys Tyr Leu Lys Thr 370 375 380 Ile Leu Glu Asn Ile Glu Gly Ala Asp Tyr Phe Ile Ala Lys Ile Glu 385 390 395 400 Glu Glu Asn Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Ala Ile 405 410 415 Pro His Gin Leu His Leu Glu Glu Leu Glu Ala Ile Ile His Gin Gin 420 425 430 Ala Lys Tyr Tyr Pro Phe Leu Arg Glu Asp Tyr Glu Lys Ile Lys Ser 435 440 445 Leu Val Thr Phe Arg Ile Pro Tyr Phe Val Gly Pro Leu Ala Lys Gly 450 455 460 Gin Ser Glu Phe Ala Trp Leu Thr Arg Lys Ala Asp Gly Glu Ile Arg 465 470 475 480 Pro Trp Asn Ile Glu Glu Lys Val Asp Phe Gly Lys Ser Ala Val Asp 485 490 495 Phe Ile Glu Lys Met Thr Asn Lys Asp Thr Tyr Leu Pro Lys Glu Asn 500 505 510 Val Leu Pro Lys His Ser Leu Cys Tyr Gin Lys Tyr Met Val Tyr Asn Page 2520 of 3790 515 520 525 Glu Leu Thr Lys Val Arg Tyr Ile Asp Asp Gin Gly Lys Thr Asn Tyr 530 535 540 Phe Ser Gly Gin Glu Lys Gin Gin Ile Phe Asn Asp Leu Phe Lys Gin 545 550 555 560 Lys Arg Lys Val Lys Lys Lys Asp Leu Glu Leu Phe Leu Arg Asn Ile 565 570 575 Asn His Ile Glu Ser Pro Thr Ile Glu Gly Leu Glu Asp Ser Phe Asn 580 585 590 Ala Ser Tyr Ala Thr Tyr His Asp Leu Leu Lys Val Gly Met Lys Gin 595 600 605 Glu Ile Leu Asp Asn Pro Leu Asn Thr Glu Met Leu Glu Asp Ile Val 610 615 620 Lys Ile Leu Thr Val Phe Glu Asp Lys Pro Met Ile Lys Glu Gin Leu 625 630 635 640 Gin Gin Phe Ser Asp Val Leu Asp Gly Gly Val Leu Lys Lys Leu Glu 645 650 655 Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Val 660 665 670 Gly Ile Arg Glu Lys Gin Ser His Leu Thr Ile Leu Asp Tyr Leu Met 675 680 685 Asn Asp Asp Gly Leu Asn Arg Asn Leu Met Gin Leu Ile Asn Asp Ser 690 695 700 Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin Val Ser Thr Thr 705 710 715 720 Asp Lys Asp Leu Gin Ser Ile Val Ala Asp Leu Ala Gly Ser Pro Ala 725 730 735 Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val 740 745 750 Ser Ile Met Gly Tyr Pro Pro Gin Thr Ile Val Val Glu Met Ala Arg 755 760 765 Page 2521 of 3790 Page 2522 of 3790 Page 2523 of 3790 1068 874 PRT Listeria seeligeri 1068 Page 2524 of 3790 Gly Val Pro Gin Glu Ile Leu Asp Asp Pro Leu Asn Thr Glu Met Leu 145 150 155 160 Glu Glu Ile Ile Lys Ile Leu Thr Val Phe Glu Asp Lys Arg Met Ile 165 170 175 Asn Glu Arg Leu Gin Glu Phe Ser Asn Val Leu Asp Glu Ala Val Leu 180 185 190 Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu Ser Ala 195 200 205 Lys Leu Leu Ile Gly Ile Arg Asp Lys Glu Ser His Leu Thr Ile Leu 210 215 220 Asp Tyr Leu Met Asn Asp Asp Lys His Asn Arg Asn Leu Met Gin Leu 225 230 235 240 Ile Asn Asp Ser Asn Leu Ser Phe Lys Ser Ile Ile Glu Lys Glu Gin 245 250 255 Val Ser Thr Ala Asp Lys Asp Ile Gin Ser Ile Val Ala Asp Leu Ala 260 265 270 Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Ile Val 275 280 285 Asp Glu Leu Val Gly Ile Met Gly Tyr Pro Pro Gin Thr Ile Val Val 290 295 300 Glu Met Ala Arg Glu Asn Gin Thr Thr Gly Lys Gly Lys Asn Asn Ser 305 310 315 320 Lys Pro Arg Phe Thr Ser Leu Glu Lys Ala Ile Lys Glu Leu Gly Ser 325 330 335 Gin Ile Leu Lys Glu His Pro Thr Asp Asn Gin Gly Leu Lys Asn Asp 340 345 350 Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly 355 360 365 Gin Glu Leu Asp Ile His Asn Leu Ser Asn Tyr Asp Ile Asp His Val 370 375 380 Val Pro Gin Ser Phe Ile Thr Asp Asn Ser Ile Asp Asn Arg Val Leu Page 2526 of 3790 865 870 1069 1087 PRT Page 2527 of 3790 Page 2528 of 3790 Gly Asp Thr Trp Asp Asn Leu Phe Glu Ile Leu Ile Gly Lys Cys Ser 245 250 255 Val Phe Pro Glu Glu Thr Arg Ala Ala Arg Ser Ser Tyr Val Ala Gin 260 265 270 Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Lys Ile Ser Asn Leu 275 280 285 Glu Ser Gly Lys Leu Ser Ala Ser Gin Lys His Asp Ile Val Glu Lys 290 295 300 Val Lys Asn Ser Lys Lys Phe Gly Thr Lys Asp Leu Leu Lys Tyr Ile 305 310 315 320 Ala Ser Val Cys Glu Cys Lys Ile Glu Asp Ile Gly Gly Cys Arg Val 325 330 335 Asp Lys Asn Arg Lys Pro Ile Met His Thr Phe Glu Asn Tyr Arg Lys 340 345 350 Val His Asn Ala Leu Asn Glu Ala Gly Val Asp Leu Arg Leu Ser Glu 355 360 365 Thr Asp Tyr Asp Glu Leu Met Lys Ile Met Thr Leu Asn Ser Glu Thr 370 375 380 Leu Glu Ile Lys Lys Gin Cys Lys Glu Lys Leu Pro Gin Leu Thr Glu 385 390 395 400 Asp Tyr Leu Asn Val Cys Leu Val Leu Asn Lys Lys Gly Ala Phe Ser 405 410 415 Gly Trp His Ala Leu Ser Leu Lys Ala Met Lys Leu Met Met Pro Glu 420 425 430 Leu Tyr Gly Thr Ser Lys Asn Gin Met Gin Ile Ile His Thr Met Gin 435 440 445 Leu Gly Lys Ala Tyr Leu Lys Pro Leu Asn Gin Gin Lys Tyr Leu Asn 450 455 460 Ser Glu Ala Ile Leu Glu Glu Ile Tyr Asn Pro Ile Ala Ala Arg Ser 465 470 475 480 Ile Arg Gin Thr Ile Lys Val Thr Asn Ala Ile Leu Lys Lys Tyr Gly 485 490 495 Page 2529 of 3790 His Leu Asp Ser Val Ile Ile Glu Met Pro Arg Asp Tyr Gin Thr Ser 500 505 510 Glu Asp Glu Arg Lys Met Ile Glu Lys Met Gin Lys Glu Asn Glu Lys 515 520 525 Glu Lys Lys Ala Ala Leu Lys Arg Ala Arg Glu Glu Tyr Pro Phe Pro 530 535 540 Asp Glu Ala Phe Arg Asn His Lys Glu Leu Ala Thr Lys Leu Arg Leu 545 550 555 560 Trp Tyr Gin Gin Asp Gin Phe Cys Val Tyr Ser Gly Arg Lys Ile Ser 565 570 575 Val Val Asp Leu Val Arg Asn Pro Asn Gin Phe Glu Ile Asp His Ile 580 585 590 Ile Pro Gin Ser Val Ser Leu Asp Asp Ser Leu Asn Asn Lys Val Leu 595 600 605 Cys Phe Ser Glu Glu Asn Gin Lys Lys Gly Gin Gin Thr Pro Phe Tyr 610 615 620 Tyr His Lys Gly Lys Ser Gly Asn Trp Thr Tyr Glu Gin Tyr Lys Leu 625 630 635 640 Phe Val Glu Lys Leu Phe Asp Lys Lys Lys Ile Ser Asn Lys Lys Arg 645 650 655 Glu Leu Leu Leu Phe Glu Glu Asp Ile Asn Lys Trp Asp Val Arg Arg 660 665 670 Gly Phe Ile Ala Arg Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val 675 680 685 Ile Leu Asn Ser Tyr Gin Gin Tyr Phe Gly Asn His Glu Met Gly Thr 690 695 700 Lys Val Lys Val Val Arg Gly Lys Phe Thr Ser Gin Leu Arg Lys Lys 705 710 715 720 Trp Arg Ile Phe Lys Asp Arg Asn Glu Ser His Ser His His Ala Ile 725 730 735 Asp Ala Leu Ile Val Ala Ala Thr Ala Asn Leu Arg Leu Trp Lys Lys Page 2531 of 3790 Glu Lys Glu Gin Ile His Ser Glu Met Lys Phe Cys Phe Ser Leu Tyr 995 1000 1005 Arg Asn Ile Glu 1085 1070 1345 PRT Marinilabilia sp. Page 2532 of 3790 Asp Lys Ala Ala Lys Glu Lys Ile Glu Leu Asp Asp Leu Val Lys Val 115 120 125 Leu Leu Gin Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Ala 130 135 140 Lys Ser Glu Glu Asp Asp Gly Ser Ala Ile Asp Ser Met Gly Ile Ala 145 150 155 160 Lys Glu Leu Tyr Glu Asn Asp Leu Thr Pro Gly Gin Trp Val Phe Glu 165 170 175 Ala Leu Gin Lys Gly Arg Lys Asn Val Pro Asp Phe Tyr Arg Ser Asp 180 185 190 Leu Gin Glu Glu Phe Lys Lys Ile Val Asn Tyr Gin Ser Glu Phe Tyr 195 200 205 Pro Asp Val Leu Asn Ser Ser Phe Val Glu Asp Trp Met Gly Lys Ala 210 215 220 Ser Thr Pro Thr Lys Gin Tyr Phe Asn Lys Lys Gly Val His Leu Ala 225 230 235 240 Glu Asn Lys Gly Lys Arg Glu Glu Arg Arg Leu Gin Glu Tyr Asn Trp 245 250 255 Arg Ala Val Ala Val Asn Ser Lys Ile Asp Leu Ser Glu Ile Ala Leu 260 265 270 Ile Leu Ser Gin Ile Asn Ser Gin Ile Ser Asn Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Lys Asn Gin Thr 290 295 300 Val Gly Gin Tyr Leu Tyr Gin Gin Ile Lys Ile Asn Pro His Thr Arg 305 310 315 320 Leu Lys Gly Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Lys Ile Trp Ser Val Gin Ser Gly Phe His Pro Gin Leu Asn Asp Ala 340 345 350 Leu Lys Lys Glu Ile Arg Asp Ile Thr Ile Phe Phe Gin Arg Arg Leu 355 360 365 Page 2533 of 3790 Lys Ser Gin Lys His Leu Ile Ser Asn Cys Glu Phe Glu Asp Tyr His 370 375 380 Lys Val Val Pro Lys Ser His Pro Ile Phe Gin Glu Phe Arg Ile Trp 385 390 395 400 Gin Asn Leu Asn Asn Leu Thr Leu Ile Lys Lys Asp Asn Leu Asn Glu 405 410 415 Lys Ser Glu Leu Ala Leu Glu Asp Lys Ile Ala Leu Ala Asn Glu Leu 420 425 430 Ala Phe Lys Arg Glu Gin Ser Val Lys Asp Ala Leu Asn Ile Leu Gly 435 440 445 Leu Lys Ser Ser Glu Trp Glu Phe Asn Phe Thr Lys Ile Glu Gly Asn 450 455 460 Arg Thr Asn His Ala Phe Phe Glu Ala Phe Ala Lys Ile Ile Glu Ile 465 470 475 480 Glu Asp Gly Glu Pro Leu Asp Leu Gly Asn Leu Lys Ala Asp Asp Ile 485 490 495 Leu Asp Gin Phe Ser Glu Ala Phe Leu Arg Ile Gly Ile Asp Pro Gly 500 505 510 Leu Leu Gin Val Asn Asn Asp Ile Glu Gly Pro Asn Tyr Glu Lys Gin 515 520 525 Pro Tyr Ile Gin Phe Trp His Leu Leu Tyr Ser Ser Glu Asp Asp Gin 530 535 540 Lys Leu Lys Gin Asn Leu Ile Lys Lys Phe Gly Phe Lys Pro Asp His 545 550 555 560 Ala Lys Ile Leu Ala Ser Ile Ser Leu Gin Asp Asp His Ala Ser Leu 565 570 575 Ser Ser Arg Ala Ile Lys Lys Ile Leu Pro His Leu Gin Ser Gly Leu 580 585 590 Ile Tyr Asp Lys Ala Cys Thr Tyr Ala Gly Tyr Asn His Ser Ser Ser 595 600 605 Phe Thr Lys Glu Glu Asn Glu Lys Arg Glu Leu Ser Ser Glu Leu Asp 610 615 620 Page 2534 of 3790 Leu Leu Lys Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu 625 630 635 640 Asn Gin Met Ile Asn Val Val Asn Ala Ile Leu Lys Asp Pro Asn Leu 645 650 655 Gly Lys Pro Asp Glu Ile Arg Val Glu Met Ala Arg Glu Leu Lys Ala 660 665 670 Asn Ala Glu Gin Arg Lys Asn Met Thr Ser Asn Ile Ala Ser Ala Thr 675 680 685 Arg Asp His Glu Lys Tyr Arg Glu Ile Leu Lys Lys Glu Phe Gly Leu 690 695 700 Lys Arg Val Thr Lys Asn Asp Leu Leu Arg Tyr Lys Leu Trp Leu Glu 705 710 715 720 Thr Asp Gly Ile Ser Leu Tyr Thr Gly Lys Pro Ile Glu Ala Ser Lys 725 730 735 Leu Phe Ser Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Lys Thr Arg 740 745 750 Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Ile Cys Glu Arg Gin Leu 755 760 765 Asn Ile Asp Lys Ala Asn Val Thr Ala Phe Ser Phe Leu Gin Asn Lys 770 775 780 Leu Ser Gly Asp Glu Phe Glu Gin Tyr Gin Ser Arg Val Lys Ser Leu 785 790 795 800 Phe Gly Lys Leu Ser Lys Ala Lys Ile Gin Lys Leu Leu Met Ala Asn 805 810 815 Asp Lys Ile Pro Glu Asp Phe Ile Ala Arg Gin Leu Gin Glu Thr Arg 820 825 830 Tyr Ile Ser Lys Lys Ala Lys Glu Ile Leu Phe Glu Ile Thr Arg Arg 835 840 845 Val Ser Val Thr Thr Gly Thr Ile Thr Asp Lys Leu Arg Glu Asp Trp 850 855 860 Gly Leu Val Glu Ile Met Lys Glu Leu Asn Trp Glu Lys Tyr Asp Lys 880 865 870 Page 2535 of 3790 875 Val Leu Glu Gin Asn Tyr Thr Ile Arg Lys Asn Ile Asp Pro Asp 1100 1105 1110 Page 2536 of 3790 Ile Ile Gin Val Gly Glu Tyr 1340 1345 Page 2537 of 3790 1071 1091 PRT Mobiluncus mulieris Page 2538 of 3790 Thr Leu Asn Arg Ile Ile Asp Arg Val Phe Ser Ser Lys Ser Pro Lys 225 230 235 240 Gly Lys Ala Ser Glu Arg Val Gly Met Asp Ala Leu Pro Gly Gin Gly 245 250 255 Ser Lys Pro Arg Ala Leu Lys Ala Met Pro Ser Phe Gin Lys Phe Arg 260 265 270 Val Val Ser Val Ile Cys Asn Leu Arg Ile Lys Asp Ser Gly Gly Asp 275 280 285 Ala Arg Pro Leu Ser Met Glu Glu Lys Glu Lys Leu Ile Asp Tyr Leu 290 295 300 Met Ser Ser Thr Thr Asp Asp His Val Thr Trp Thr Asp Val Ala Asp 305 310 315 320 Leu Leu His Val Lys Arg Ser Gin Leu Gin Gly Thr Ala Lys Glu Gly 325 330 335 Phe Asp Gly Glu Arg Pro Tyr Thr Arg Pro Pro Val Asn Ser Thr Trp 340 345 350 Ser Lys Ile Lys Asp Ser Lys Ile Lys Ser Leu Val Ala Leu Trp Lys 355 360 365 Thr Gly Asp Val Asp Val Gin Ser Ala Ile Val Glu Ala Leu Ser Asn 370 375 380 Ala Ser Val Leu Glu Asp Ser Arg Pro Gly Ala Asp Ile Val Val Ala 385 390 395 400 Tyr Leu Glu Ser Leu Asp Asp Lys Glu Leu Glu Ser Leu Asp Lys Val 405 410 415 Gly Leu Pro Ala Gly Arg Ala Ser Tyr Ser Glu Asp Ser Leu Glu Arg 420 425 430 Leu Thr Glu Arg Met Leu Arg Asp Asp Cys Asp Leu Phe Glu Ala Arg 435 440 445 Lys Arg Glu Phe Asn Val Ala Asp Asp Trp Lys Pro Pro Ala Asp Pro 450 455 460 Ile Tyr Ala Pro Val Gly Asn Pro Gly Val Asp Arg Val Leu Lys Ile 465 470 475 480 Page 2539 of 3790 Val Asn Arg Leu Leu Met Ala Ala Glu Arg Glu Trp Gly Ala Pro Thr 485 490 495 Gin Ile Asn Ile Glu His Val Arg Ser Gly Phe Ser Ser Glu Leu Met 500 505 510 Gin Arg Glu Phe Glu Arg Glu Asn Glu Arg Arg Arg Ala Gin Asn Glu 515 520 525 Glu Ala Val Lys Ala Ile Leu Thr Glu Lys Gly Gly Asn Ser Arg Val 530 535 540 Ser Lys Tyr Asp Ile Thr Arg Tyr Tyr Ala Val Lys Arg Gin His Cys 545 550 555 560 Gin Cys Leu Tyr Cys Gly Thr Pro Ile Thr Phe Ser Asp Cys Glu Leu 565 570 575 Asp His Ile Val Pro Arg Lys Gly Val Gly Ser Thr Asn Thr Arg Val 580 585 590 Asn Leu Ala Ala Ala Cys Arg Ser Cys Asn Arg Asp Lys Ser Asn Leu 595 600 605 Pro Phe Ala Val Trp Ala Gly Lys Ala Ser Asn Phe Asp Val Ser Ile 610 615 620 Asp Asp Ala Val Ser Arg Val Lys Gin Trp Gin Arg Ser Gin Asn Glu 625 630 635 640 Gly Val Arg Glu Phe Arg Ala Phe Gin Asn Glu Val Ile Ser Arg Leu 645 650 655 Leu Lys Thr Thr Glu Asp Pro Glu Ile Asp Ser Arg Ser Leu Glu Ser 660 665 670 Val Ala Trp Met Ala Arg Glu Leu His His Arg Val Glu Tyr Tyr Phe 675 680 685 Gin Ser Lys Gly Ala Gin Thr Gin Val Ser Val Tyr Arg Gly Ala Val 690 695 700 Thr Ala Gin Ala Arg Lys Ser Ser Gly Leu Glu Asp Lys Val Lys Met 705 710 715 720 Ile Gly Gly Gly Gly Lys Thr Arg Leu Asp Arg Arg His His Ala Met Page 2541 of 3790 Tyr Leu Gly Trp Leu Val Pro Gly Asp Glu Ile Ile Val Asp Thr Ser 980 985 990 Asp Lys Ala Phe His Thr Gly Gin Ile Gly Asp Leu Leu Arg Asn Phe 995 1000 1005 1072 1233 PRT Mycoplasma canis Page 2542 of 3790 Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gin Glu Val Cys 100 105 110 Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 115 120 125 Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gin Gin Thr 130 135 140 Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 145 150 155 160 Gly Tyr Phe Lys Gly Ala Leu Ser Gin Pro Thr Glu Ser Glu Met Lys 165 170 175 Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 180 185 190 Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gin Lys Asn Ile 195 200 205 Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 210 215 220 Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 225 230 235 240 Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gin Gly Gly Arg Tyr Glu 245 250 255 His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 260 265 270 Gin Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 275 280 285 Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 290 295 300 Gin Pro Leu Trp Lys Leu Ser Ser Ile Asp Lys Leu Asn Ile Leu Leu 305 310 315 320 Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Asn 325 330 335 Ala Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Thr Lys Ser Ile Met 340 345 350 Page 2543 of 3790 Leu Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 355 360 365 Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 370 375 380 Ser Ala Lys Glu Asn Lys Phe Lys Phe Gin Asp Leu Lys Ile Leu Asn 385 390 395 400 Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 405 410 415 Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 420 425 430 Leu Phe Leu Ile Tyr Gin Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 435 440 445 Asp Leu Phe Ile Ala Lys Asn Glu Leu Leu Asn Ile Glu Asn Leu Lys 450 455 460 Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 465 470 475 480 His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 485 490 495 Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 500 505 510 Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gin Ile Glu Asp Asn Ser Ser 515 520 525 Leu Met Ala Lys Gin Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 530 535 540 Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gin Gin Ala Ile 545 550 555 560 Leu Ile Phe Asn Lys Ile Ile Gin Lys Phe Ser Lys Asp Phe Glu Ile 565 570 575 Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gin Asp Gin Glu 580 585 590 Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gin Lys Ser Lys Lys Ser 595 600 605 Page 2544 of 3790 Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 610 615 620 Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 625 630 635 640 Gin Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gin Ile Ser Thr Asn Glu 645 650 655 Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 660 665 670 Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gin Ser 675 680 685 Asn Gin Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gin Gly 690 695 700 His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 705 710 715 720 Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 725 730 735 Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 740 745 750 Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 755 760 765 Phe Arg Asp Gin Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 770 775 780 Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 785 790 795 800 Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 805 810 815 Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 820 825 830 Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn 835 840 845 Gly Ile Ile Ser Lys Arg Ser Glu Gly Tyr Trp Val Ile Glu Asp Arg 850 855 Page 2545 of 3790 860 Ala Phe Tyr Glu Asn Ile Asn Ser Leu Gly Ala Ile Val Phe Lys 1085 1090 1095 Page 2546 of 3790 1073 1233 PRT Mycoplasma canis Page 2547 of 3790 Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 85 90 95 Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gin Glu Val Cys 100 105 110 Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 115 120 125 Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gin Gin Thr 130 135 140 Ile Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 145 150 155 160 Gly Tyr Phe Lys Gly Ala Leu Ser Gin Pro Thr Glu Ser Glu Met Lys 165 170 175 Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 180 185 190 Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gin Lys Asn Ile 195 200 205 Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 210 215 220 Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 225 230 235 240 Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gin Gly Gly Arg Tyr Glu 245 250 255 His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 260 265 270 Gin Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 275 280 285 Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 290 295 300 Gin Pro Leu Trp Lys Leu Ser Ser Ile Asp Lys Leu Asn Ile Leu Leu 305 310 315 320 Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 325 330 335 Page 2548 of 3790 Ala Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Thr Lys Ser Ile Met 340 345 350 Leu Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 355 360 365 Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 370 375 380 Ser Ala Lys Glu Asn Lys Phe Lys Phe Gin Asp Leu Lys Ile Leu Asn 385 390 395 400 Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 405 410 415 Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 420 425 430 Leu Phe Leu Ile Tyr Gin Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 435 440 445 Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 450 455 460 Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 465 470 475 480 His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 485 490 495 Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 500 505 510 Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gin Ile Glu Asp Asn Ser Phe 515 520 525 Leu Met Ala Lys Gin Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 530 535 540 Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gin Gin Ala Ile 545 550 555 560 Leu Ile Phe Asn Lys Ile Ile Gin Lys Phe Ser Lys Asp Phe Glu Ile 565 570 575 Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gin Asp Gin Glu 580 585 590 Page 2549 of 3790 Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gin Lys Ser Lys Lys Ser 595 600 605 Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 610 615 620 Asn Glu Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 625 630 635 640 Gin Asp Phe Lys Asp Pro Tyr Thr Gly Ala Lys Ile Ser Ala Asn Glu 645 650 655 Ile Val Asp Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 660 665 670 Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gin Ser 675 680 685 Asn Gin Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gin Gly 690 695 700 His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 705 710 715 720 Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 725 730 735 Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 740 745 750 Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 755 760 765 Phe Arg Asp Gin Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asp 770 775 780 Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 785 790 795 800 Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asn Arg 805 810 815 Asn Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 820 825 830 Ser Asn Lys Thr Lys Thr Leu Tyr Asn Leu Ile Asp Pro Ser Leu Asn Page 2550 of 3790 Page 2551 of 3790 1074 1233 PRT Mycoplasma canis Page 2552 of 3790 Gin Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 65 70 75 80 Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 85 90 95 Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gin Glu Val Cys 100 105 110 Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 115 120 125 Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gin Gin Thr 130 135 140 Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 145 150 155 160 Gly Tyr Phe Lys Gly Ala Leu Ser Gin Pro Thr Glu Ser Glu Met Lys 165 170 175 Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 180 185 190 Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gin Lys Asn Ile 195 200 205 Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 210 215 220 Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 225 230 235 240 Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gin Gly Gly Arg Tyr Glu 245 250 255 His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 260 265 270 Gin Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 275 280 285 Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 290 295 300 Gin Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 305 310 315 320 Page 2553 of 3790 Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 325 330 335 Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 340 345 350 Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 355 360 365 Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 370 375 380 Ser Ala Lys Glu Asn Lys Phe Lys Phe Gin Asp Leu Lys Ile Leu Asn 385 390 395 400 Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 405 410 415 Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 420 425 430 Leu Phe Leu Ile Tyr Gin Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 435 440 445 Asp Leu Phe Ile Ala Lys Asn Glu Ser Leu Asn Ile Glu Asn Leu Lys 450 455 460 Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 465 470 475 480 His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Glu Ile 485 490 495 Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 500 505 510 Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gin Ile Glu Asp Asn Ser Ser 515 520 525 Leu Met Ala Lys Gin Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 530 535 540 Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gin Gin Ala Ile 545 550 555 560 Leu Ile Phe Asn Lys Ile Ile Gin Lys Phe Ser Lys Asp Phe Glu Ile 565 570 575 Page 2554 of 3790 Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gin Asp Gin Glu 580 585 590 Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gin Lys Ser Lys Lys Ser 595 600 605 Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 610 615 620 Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 625 630 635 640 Gin Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gin Ile Ser Val Asn Glu 645 650 655 Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 660 665 670 Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gin Ser 675 680 685 Asn Gin Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gin Gly 690 695 700 His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 705 710 715 720 Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 725 730 735 Lys Ser Glu Asn Leu Leu Thr Ala Ser Tyr Asp Gly Tyr Asp Lys Leu 740 745 750 Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 755 760 765 Phe Arg Asp Gin Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 770 775 780 Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 785 790 795 800 Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 805 810 815 Ser Asp Phe Ser His His Ala Tyr Asp Ala Ala Ile Ile Ala Leu Phe 820 Page 2555 of 3790 825 830 1075 1233 PRT Mycoplasma canis Page 2557 of 3790 Thr Gin Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 50 55 60 Gin Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 65 70 75 80 Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 85 90 95 Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gin Glu Val Cys 100 105 110 Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 115 120 125 Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gin Gin Thr 130 135 140 Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 145 150 155 160 Gly Tyr Phe Lys Gly Ala Leu Ser Gin Pro Thr Glu Ser Glu Met Lys 165 170 175 Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 180 185 190 Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gin Lys Asn Ile 195 200 205 Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 210 215 220 Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 225 230 235 240 Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gin Gly Gly Arg Tyr Glu 245 250 255 His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 260 265 270 Gin Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 275 280 285 Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 290 295 300 Page 2558 of 3790 Gin Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 305 310 315 320 Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 325 330 335 Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 340 345 350 Ile Ser Val Glu Asp Ile Asp Met Ile Lys Asp Glu Trp Ala Gly Lys 355 360 365 Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 370 375 380 Asn Ala Lys Glu Asn Lys Phe Lys Phe Gin Asp Leu Lys Ile Leu Asn 385 390 395 400 Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 405 410 415 Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 420 425 430 Leu Phe Leu Ile Tyr Gin Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 435 440 445 Asp Leu Phe Ile Ala Lys Asn Lys Ser Leu Asn Ile Glu Asn Leu Lys 450 455 460 Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 465 470 475 480 His Asn Ser Lys Ser His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 485 490 495 Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 500 505 510 Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gin Ile Glu Asp Asn Ser Ser 515 520 525 Leu Met Ala Lys Gin Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 530 535 540 Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gin Gin Ala Ile 545 550 555 560 Page 2559 of 3790 Leu Ile Phe Asn Lys Ile Ile Gin Lys Phe Ser Lys Asp Phe Glu Ile 565 570 575 Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gin Asp Gin Glu 580 585 590 Asn Asp Ala Leu Lys Gly Met Ala Lys Ala Gin Lys Ser Lys Lys Ser 595 600 605 Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 610 615 620 Asn Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 625 630 635 640 Gin Asp Phe Lys Asp Pro Tyr Thr Gly Ala Gin Ile Ser Val Asn Glu 645 650 655 Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 660 665 670 Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gin Ser 675 680 685 Asn Gin Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gin Gly 690 695 700 His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 705 710 715 720 Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 725 730 735 Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 740 745 750 Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 755 760 765 Phe Arg Asp Gin Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 770 775 780 Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 785 790 795 800 Ile Arg Lys Asn Met Ser Tyr Asp Asn Lys Leu Arg Leu Lys Asp Arg 805 815 Page 2560 of 3790 810 1076 1233 PRT Mycoplasma canis Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Gin Val Tyr Lys 20 25 30 Page 2562 of 3790 Leu Gly Ser Arg Leu Phe Asp Ala Pro Asp Thr Asn Leu Glu Arg Arg 35 40 45 Thr Gin Arg Gly Thr Arg Arg Leu Leu Arg Arg Arg Lys Tyr Arg Asn 50 55 60 Gin Lys Phe Tyr Asn Leu Val Lys Arg Thr Glu Val Phe Gly Leu Ser 65 70 75 80 Ser Arg Glu Ala Ile Glu Asn Arg Phe Arg Glu Leu Ser Ile Lys Tyr 85 90 95 Pro Asn Ile Ile Glu Leu Lys Thr Lys Ala Leu Ser Gin Glu Val Cys 100 105 110 Pro Asp Glu Ile Ala Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 115 120 125 Tyr Phe Tyr Asp Glu Lys Glu Thr Lys Glu Asp Phe Asp Gin Gin Thr 130 135 140 Val Glu Ser Met Pro Ser Tyr Lys Leu Asn Glu Phe Tyr Lys Lys Tyr 145 150 155 160 Gly Tyr Phe Lys Gly Ala Leu Ser Gin Pro Thr Glu Ser Glu Met Lys 165 170 175 Asp Asn Lys Asp Leu Lys Glu Ala Phe Phe Phe Asp Phe Ser Asn Lys 180 185 190 Glu Trp Leu Lys Glu Ile Asn Tyr Phe Phe Asn Val Gin Lys Asn Ile 195 200 205 Leu Ser Glu Thr Phe Ile Glu Glu Phe Lys Lys Ile Phe Ser Phe Thr 210 215 220 Arg Asp Ile Ser Lys Gly Pro Gly Ser Asp Asn Met Pro Ser Pro Tyr 225 230 235 240 Gly Ile Phe Gly Glu Phe Gly Asp Asn Gly Gin Gly Gly Arg Tyr Glu 245 250 255 His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Thr Asn Glu 260 265 270 Gin Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Ile Phe Asn Phe Leu 275 280 285 Page 2563 of 3790 Asn Glu Leu Ala Asn Ile Arg Leu Tyr Ser Thr Asp Lys Lys Asn Ile 290 295 300 Gin Pro Leu Trp Lys Leu Ser Ser Val Asp Lys Leu Asn Ile Leu Leu 305 310 315 320 Asn Leu Phe Asn Leu Pro Ile Ser Glu Lys Lys Lys Lys Leu Thr Ser 325 330 335 Thr Asn Ile Asn Asp Ile Val Lys Lys Glu Ser Ile Lys Ser Ile Met 340 345 350 Leu Ser Val Glu Asp Ile Asp Met Ile Lys Tyr Glu Trp Ala Gly Lys 355 360 365 Glu Pro Asn Val Tyr Gly Val Gly Leu Ser Gly Leu Asn Ile Glu Glu 370 375 380 Ser Ala Lys Glu Asn Lys Phe Lys Phe Gin Asp Leu Lys Ile Leu Asn 385 390 395 400 Val Leu Ile Asn Leu Leu Asp Asn Val Gly Ile Lys Phe Glu Phe Lys 405 410 415 Asp Arg Asn Asp Ile Ile Lys Asn Leu Glu Leu Leu Asp Asn Leu Tyr 420 425 430 Leu Phe Leu Ile Tyr Gin Lys Glu Ser Asn Asn Lys Asp Ser Ser Ile 435 440 445 Asp Leu Phe Ile Ala Lys Asn Lys Ser Leu Asn Ile Glu Asn Leu Lys 450 455 460 Leu Lys Leu Lys Glu Phe Leu Leu Gly Ala Gly Asn Glu Phe Glu Asn 465 470 475 480 His Asn Ser Lys Thr His Ser Leu Ser Lys Lys Ala Ile Asp Ala Ile 485 490 495 Leu Pro Lys Leu Leu Asp Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 500 505 510 Lys Asn Tyr Asp Glu Glu Ile Lys Ser Gin Ile Glu Asp Asn Ser Ser 515 520 525 Leu Met Ala Lys Gin Asp Lys Lys Tyr Leu Asn Asp Asn Phe Leu Lys 530 535 540 Page 2564 of 3790 Asp Ala Ile Leu Pro Pro Asn Val Lys Val Thr Phe Gin Gin Ala Ile 545 550 555 560 Leu Ile Phe Asn Lys Ile Ile Gin Lys Phe Ser Lys Asp Phe Glu Ile 565 570 575 Asp Lys Val Val Ile Glu Leu Ala Arg Glu Met Thr Gin Asp Gin Glu 580 585 590 Asn Asp Ala Leu Lys Gly Ile Ala Lys Ala Gin Lys Ser Lys Lys Ser 595 600 605 Leu Val Glu Glu Arg Leu Glu Ala Asn Asn Ile Asp Lys Ser Val Phe 610 615 620 Asp Asp Lys Tyr Glu Lys Leu Ile Tyr Lys Ile Phe Leu Trp Ile Ser 625 630 635 640 Gin Asp Phe Lys Asp Pro Tyr Thr Gly Ala Lys Ile Ser Ala Asn Glu 645 650 655 Ile Val Asn Asn Lys Val Glu Ile Asp His Ile Ile Pro Tyr Ser Leu 660 665 670 Cys Phe Asp Asp Ser Ser Ala Asn Lys Val Leu Val His Lys Gin Ser 675 680 685 Asn Gin Glu Lys Ser Asn Ser Leu Pro Tyr Glu Tyr Ile Lys Gin Gly 690 695 700 His Ser Gly Trp Asn Trp Asp Glu Phe Thr Lys Tyr Val Lys Arg Val 705 710 715 720 Phe Val Asn Asn Val Asp Ser Ile Leu Ser Lys Lys Glu Arg Leu Lys 725 730 735 Lys Ser Glu Asn Leu Leu Thr Thr Ser Tyr Asp Gly Tyr Asp Lys Leu 740 745 750 Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala Thr Ile Leu 755 760 765 Phe Arg Asp Gin Leu Asn Asn Tyr Ala Glu His His Leu Ile Asp Asn 770 775 780 Lys Lys Met Phe Lys Val Ile Ala Met Asn Gly Ala Val Thr Ser Phe 800 785 790 Page 2565 of 3790 795 Leu Tyr Leu Lys Gin Tyr Met Arg Ser Leu Thr Lys Ser Leu Asp 1010 1015 1020 Gin Phe Ser Glu Glu Phe Ile Asn Gin Met Ile Ala Asn Lys Thr 1025 1030 1035 1077 1239 PRT Mycoplasma cynos 1077 Met Glu Glu Lys Arg Lys Val Thr Leu Gly Phe Asp Leu Gly Val Ala 15 10 15 Page 2567 of 3790 Ser Val Gly Trp Ala Ile Val Asp Ser Glu Thr Asn Glu Val Tyr Lys 20 25 30 Leu Gly Ser Arg Leu Phe Asp Ile Pro Asp Thr Asn Ile Asp Arg Arg 35 40 45 Ala Lys Arg Gly Ser Arg Arg Leu Val Arg Arg Arg Ser Tyr Arg Asn 50 55 60 Gin Lys Phe Tyr Asn Leu Ile Lys Arg Thr Lys Thr Phe Gly Phe Leu 65 70 75 80 Asp Lys Glu Ala Ile Glu Lys Glu Phe Val Leu Leu Ser Ile Lys Tyr 85 90 95 Pro Asn Ile Ile Glu Leu Lys Val Lys Gly Leu Gin Glu Glu Val Ser 100 105 110 Lys Ser Glu Ala Val Trp Ile Leu His Asp Tyr Leu Lys Asn Arg Gly 115 120 125 Tyr Phe Tyr Asp Asp Lys Glu Glu Lys Asp Asp Leu Glu Asn Pro Ser 130 135 140 Ile Glu Ser Met Pro Ser Tyr Lys Leu Tyr Glu Phe Tyr Lys Glu Tyr 145 150 155 160 Gly Tyr Phe Lys Gly Ala Leu Ser Ser Pro Thr Glu Ser Glu Lys Asn 165 170 175 Lys Asp Ser Asp Leu Glu Lys Ala Ile Phe Phe Asn Phe Ser Asn Lys 180 185 190 Glu Trp Thr Lys Glu Ile Asn His Phe Phe Lys Ile Gin Lys Asn Ile 195 200 205 Phe Ser Glu Asp Phe Lys Ala Lys Phe Met Glu Phe Phe Ser Phe Ile 210 215 220 Arg Asp Ile Ser Lys Gly Pro Gly Ser Glu Asn Met Pro Ser Gin Tyr 225 230 235 240 Ser Ile Phe Gly Lys Tyr Gly Asp Asp Gly Met Gly Gly Lys Tyr Gin 245 250 255 His Ile Trp Asp Lys Asn Ile Gly Lys Cys Ser Ile Phe Lys Asp Lys 260 265 270 Page 2568 of 3790 Val Arg Ala Pro Lys Tyr Leu Pro Ser Ala Leu Phe Phe Asn Leu Leu 275 280 285 Asn Glu Leu Ser Asn Ile Arg Leu Tyr Ser Val Asp Lys Arg Glu Lys 290 295 300 Ser Val Leu Trp Arg Leu Ser Ser Lys Asp Lys Ile Asn Ile Ile Leu 305 310 315 320 Asn Ile Leu Gin Ile Ile Leu Phe Lys Asn Asp Gly Lys Ile Ser Asn 325 330 335 Leu Asp Ile Asn Lys Ile Val Lys Asn Glu Ser Ile Lys Ser Ile Ile 340 345 350 Leu Asn Glu Ile Asp Leu Asp Leu Ile Lys Asp Met Trp Phe Glu Lys 355 360 365 Glu Pro Asn Val Tyr Gly Ile Gly Leu Ser Gly Leu Asn Ile Glu Glu 370 375 380 Asn Lys Lys Glu Asn Arg Phe Lys Phe Gin Asp Leu Lys Ile Phe Ser 385 390 395 400 Val Phe Ile Asp Leu Leu Lys Lys Ser Asn Ile Asn Ile Glu Phe Asn 405 410 415 Asn Glu Lys Asp Ile Ile His Asn Leu Lys Leu Leu Asp Glu Leu Tyr 420 425 430 Phe Phe Leu Ile Thr Gin Lys Tyr Ser Arg Asp Lys Tyr Gly Ser Ile 435 440 445 Lys Lys Phe Ile Leu Asn Asn Lys Ser Phe Asn Ile Asp Asn Leu Asp 450 455 460 Glu Lys Leu Asn Ile Phe Leu Ser Ile Ser Asp Asp Glu Phe Asp Asn 465 470 475 480 His Asn Ser Lys Thr His Ser Leu Ser Lys Glu Ala Ile Tyr Phe Ile 485 490 495 Phe Pro Lys Leu Leu His Asn Asn Glu Gly Trp Asn Leu Glu Ala Ile 500 505 510 Lys Asn Tyr Asp Ile Asp Val Arg Glu Glu Ile Ser Lys His Ser Phe 515 520 525 Page 2569 of 3790 Gly Ile Lys Lys Gin Asp Lys Lys Tyr Leu Asp Asp Ala Phe Leu Asp 530 535 540 Asp Ala Ile Leu Pro Pro Ser Val Lys Val Thr Ile Lys Gin Ser Ile 545 550 555 560 Leu Ile Phe Asn Lys Ile Ile Lys Lys Phe Ser Asn Lys Phe Gin Ile 565 570 575 Asp Asn Val Val Ile Glu Leu Ala Arg Glu Met Thr Gin Glu Lys Glu 580 585 590 Met Asp Ala Gin Lys Ser Leu Asn Arg Leu Lys Lys Ser Arg Lys Lys 595 600 605 Ile Ile Glu Glu Arg Leu Asn Ala Asn Asn Ile Asp Ser Lys Met Phe 610 615 620 Arg Asp Lys Thr Gly Glu Ile Ser Pro Asn Tyr Ile Tyr Lys Ile Tyr 625 630 635 640 Leu Trp Ile Ser Gin Asn Phe Lys Asp Pro Tyr Thr Gly Glu Asn Ile 645 650 655 Ser Ala Asn Asp Ile Leu Lys Asn Asn Val Glu Ile Asp His Ile Ile 660 665 670 Pro Tyr Ser Leu Cys Phe Asp Asp Ser Ser Ser Asn Lys Val Leu Val 675 680 685 Phe Lys His Ser Asn Gin Ser Lys Gly Asn Phe Leu Pro Phe Asp Met 690 695 700 Ile Ser Thr Phe Ser Glu Asn Ser Val Trp Asn Trp Lys Glu Tyr Thr 705 710 715 720 Gin Tyr Val Glu Lys Thr Phe Lys Thr Asn Leu Glu Ser Ile Leu Asp 725 730 735 Lys Lys Glu Arg Val Lys Lys Ala Asp Asn Leu Leu Thr Ser Ser Tyr 740 745 750 Asp Gly Tyr Asp Lys Leu Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr 755 760 765 Arg Tyr Ala Thr Ile Leu Phe Arg Asp Gin Leu Ile Asn Tyr Ser Glu Lys Ile Pro Ala Arg Asp Val 995 Ala Lys Asn Ile Lys Tyr Thr Asp Asn 1000 1005 Lys Ile Lys Tyr Asn Leu Tyr Leu Lys Asp Tyr Met Arg Lys Leu 1010 1015 1020 1078 1269 PRT Page 2572 of 3790 Mycoplasma gallisepticum Page 2573 of 3790 Lys Glu Gly Lys Val Val Gin Lys Tyr Asn Asn Ile Trp Asp Lys Thr 245 250 255 Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 260 265 270 Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 275 280 285 Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gin Glu Phe 290 295 300 Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 305 310 315 320 Ser Glu Lys Pro Ile Asp Ala Arg Gin Phe Lys Lys Leu Arg Glu Glu 325 330 335 Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Arg 340 345 350 Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 355 360 365 Lys Leu Asn Thr Asn Gly Lys Ile Gin Tyr Asn Asp Leu Ser Ser Leu 370 375 380 Ala Lys Phe Val His Lys Leu Lys Gin His Leu Lys Leu Asp Phe Leu 385 390 395 400 Leu Glu Asp Gin Tyr Thr Thr Leu Asp Lys Ile Asn Phe Leu Gin Ser 405 410 415 Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 420 425 430 Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 435 440 445 Val Leu Gin Glu Gin Lys Asp Asp Leu Phe Lys Leu Phe Glu Gin Thr 450 455 460 Asp Lys Asp Asp Glu Lys Ile Leu Ala Gin Thr His Ser Leu Ser Thr 465 470 475 480 Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 485 490 495 Page 2574 of 3790 Glu Asp Asn Gin Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 500 505 510 Lys Asn Phe Asp Gin Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 515 520 525 Leu Ser Leu Lys Gin Asp Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 530 535 540 Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 545 550 555 560 Lys Val Phe Asn Ala Ile Leu Lys Gin Phe Ser Glu Glu Tyr Asp Val 565 570 575 Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 580 585 590 Leu Glu Asn Thr Lys Asn Tyr Glu Lys Leu Ile Lys Lys Asn Ser Asp 595 600 605 Lys Ile Ser Glu Arg Leu Glu Ala Leu Asp Ile Ala Glu Asp Lys Ile 610 615 620 Glu Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 625 630 635 640 Leu Gin Gin Asp His Ile Asp Pro Tyr Ser Gin Lys Glu Ile Ala Phe 645 650 655 Glu Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 660 665 670 Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val 675 680 685 Leu Ala Glu Ser Asn Gin Ala Lys Ser Asn Gin Thr Pro Tyr Glu Phe 690 695 700 Ile Thr Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 705 710 715 720 Cys Arg Lys Phe Lys Asp Gly Asp 725 Thr Ser Leu Leu Asp 730 Ser Thr Gin 735 Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys Page 2576 of 3790 Met Tyr Arg Ala Asn Pro Trp Val Ile Asn Leu Ala Glu Gin Ile Phe 995 1000 1005 Page 2577 of 3790 1079 1224 PRT Mycoplasma gallisepticum Page 2578 of 3790 Gly Leu Thr Lys Tyr Lys Phe Ser Asn Gin His Trp Leu Glu Glu Ile 180 185 190 Lys Lys Val Leu Ser Asn Gin Thr Gly Leu Pro Glu Lys Phe Lys Glu 195 200 205 Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 210 215 220 Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 225 230 235 240 Lys Glu Gly Lys Val Val Gin Lys Tyr Asn Asn Ile Trp Asp Lys Thr 245 250 255 Ile Gly Lys Cys Ser Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 260 265 270 Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 275 280 285 Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gin Glu Phe 290 295 300 Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 305 310 315 320 Ser Glu Lys Pro Ile Asp Ala Arg Gin Phe Lys Lys Leu Arg Glu Glu 325 330 335 Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Arg 340 345 350 Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 355 360 365 Lys Leu Asn Thr Asn Gly Lys Ile Gin Tyr Asn Asp Leu Ser Ser Leu 370 375 380 Ala Lys Phe Val His Lys Leu Lys Gin His Leu Lys Leu Asp Phe Leu 385 390 395 400 Leu Glu Asp Gin Tyr Thr Thr Leu Asp Lys Ile Asn Phe Leu Gin Ser 405 410 415 Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 420 425 430 Page 2579 of 3790 Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 435 440 445 Val Leu Gin Glu Gin Lys Asp Asp Leu Phe Lys Leu Phe Glu Gin Thr 450 455 460 Asp Lys Asp Asp Glu Lys Ile Leu Ala Gin Thr His Ser Leu Ser Thr 465 470 475 480 Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 485 490 495 Glu Asp Asn Gin Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 500 505 510 Lys Asn Phe Asp Gin Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 515 520 525 Leu Ser Leu Lys Gin Asp Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 530 535 540 Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 545 550 555 560 Lys Val Phe Asn Ala Ile Leu Lys Gin Phe Ser Glu Glu Tyr Asp Val 565 570 575 Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 580 585 590 Leu Glu Asn Thr Lys Asn Tyr Glu Lys Leu Ile Lys Lys Asn Ser Asp 595 600 605 Lys Ile Ser Glu Arg Leu Glu Ala Leu Asp Ile Ala Glu Asp Lys Ile 610 615 620 Glu Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Val Leu Leu Trp 625 630 635 640 Leu Gin Gin Asp His Ile Asp Pro Tyr Ser Gin Lys Glu Ile Ala Phe 645 650 655 Glu Asp Ile Leu Thr Lys Thr Glu Lys Thr Glu Ile Asp His Ile Ile 660 665 670 Pro Tyr Ser Ile Ser Phe Asp Asp Ser Ser Ser Asn Lys Leu Leu Val Page 2580 of 3790 675 680 685 Leu Ala Glu Ser Asn Gin Ala Lys Ser Asn Gin Thr Pro Tyr Glu Phe 690 695 700 Ile Thr Ser Gly Asn Ala Gly Ile Lys Trp Glu Asp Tyr Glu Ala Tyr 705 710 715 720 Cys Arg Lys Phe Lys Asp Gly Asp Thr Ser Leu Leu Asp Ser Thr Gin 725 730 735 Arg Ser Lys Lys Phe Ala Lys Met Met Lys Thr Asp Thr Ser Ser Lys 740 745 750 Tyr Asp Ile Gly Phe Leu Ala Arg Asn Leu Asn Asp Thr Arg Tyr Ala 755 760 765 Thr Ile Val Phe Arg Asp Ala Leu Lys Asp Tyr Ala Asn Asn His Leu 770 775 780 Val Glu Asp Lys Pro Met Phe Lys Val Val Cys Ile Asn Gly Gly Val 785 790 795 800 Thr Ser Phe Leu Arg Lys Asn Phe Asp Lys Ser Trp Tyr Ala Lys Lys 805 810 815 Asp Arg Asp Lys Asn Ile His His Ala Val Asp Ala Ser Ile Ile Ser 820 825 830 Ile Phe Ser Asn Glu Thr Lys Thr Leu Phe Asn Gin Leu Thr Gin Phe 835 840 845 Ala Asp Tyr Lys Leu Phe Lys Asn Thr Asp Gly Ser Trp Lys Lys Ile 850 855 860 Asp Pro Lys Thr Gly Val Val Thr Glu Val Thr Asp Glu Asn Trp Lys 865 870 875 880 Gin Ile Arg Val Arg Asn Gin Val Ser Glu Ile Ala Lys Val Ile Asn 885 890 895 Lys Cys Ile Gin Asp Ser Asn Ile Glu Arg Lys Ala Arg Tyr Ser Arg 900 905 910 Lys Ile Glu Asn Lys Thr Asn Ile Ser Leu Phe Asn Asp Thr Val Tyr 915 920 925 Page 2581 of 3790 Page 2582 of 3790 1220 1080 1269 PRT Mycoplasma gallisepticum Page 2583 of 3790 Lys Gly Ile Ile Asp Ser Lys Glu Asp Asn Asp Asn Lys Leu Glu Glu 165 170 175 Glu Leu Thr Lys Tyr Lys Phe Ser Asn Lys His Trp Leu Glu Glu Val 180 185 190 Lys Lys Val Leu Ser Asn Gin Thr Gly Leu Pro Glu Lys Phe Lys Glu 195 200 205 Glu Tyr Glu Ser Leu Phe Ser Tyr Val Arg Asn Tyr Ser Glu Gly Pro 210 215 220 Gly Ser Ile Asn Ser Val Ser Pro Tyr Gly Ile Tyr His Leu Asp Glu 225 230 235 240 Lys Glu Gly Lys Val Val Gin Lys Tyr Asn Asn Ile Trp Asp Lys Thr 245 250 255 Ile Gly Lys Cys Asn Ile Phe Pro Asp Glu Tyr Arg Ala Pro Lys Asn 260 265 270 Ser Pro Ile Ala Met Ile Phe Asn Glu Ile Asn Glu Leu Ser Thr Ile 275 280 285 Arg Ser Tyr Ser Ile Tyr Leu Thr Gly Trp Phe Ile Asn Gin Glu Phe 290 295 300 Lys Lys Ala Tyr Leu Asn Lys Leu Leu Asp Leu Leu Ile Lys Thr Asn 305 310 315 320 Gly Glu Lys Pro Ile Asp Ala Arg Gin Phe Lys Lys Leu Arg Glu Glu 325 330 335 Thr Ile Ala Glu Ser Ile Gly Lys Glu Thr Leu Lys Asp Val Glu Asn 340 345 350 Glu Glu Lys Leu Glu Lys Glu Asp His Lys Trp Lys Leu Lys Gly Leu 355 360 365 Lys Leu Asn Thr Asn Gly Lys Ile Gin Tyr Asn Asp Leu Ser Ser Leu 370 375 380 Ala Lys Phe Val His Lys Leu Lys Gin His Leu Lys Leu Asp Phe Leu 385 390 395 400 Leu Glu Asp Gin Tyr Ala Thr Leu Asp Lys Ile Asn Phe Leu Gin Ser 405 410 415 Page 2584 of 3790 Leu Phe Val Tyr Leu Gly Lys His Leu Arg Tyr Ser Asn Arg Val Asp 420 425 430 Ser Ala Asn Leu Lys Glu Phe Ser Asp Ser Asn Lys Leu Phe Glu Arg 435 440 445 Ile Leu Gin Lys Gin Lys Asp Gly Leu Phe Lys Leu Phe Glu Gin Thr 450 455 460 Asp Lys Asp Asp Glu Lys Ile Leu Ala Gin Thr His Ser Leu Ser Thr 465 470 475 480 Lys Ala Met Leu Leu Ala Ile Thr Arg Met Thr Asn Leu Asp Asn Asp 485 490 495 Glu Asp Asn Gin Lys Asn Asn Asp Lys Gly Trp Asn Phe Glu Ala Ile 500 505 510 Lys Asn Phe Asp Gin Lys Phe Ile Asp Ile Thr Lys Lys Asn Asn Asn 515 520 525 Leu Ser Leu Lys Gin Asn Lys Arg Tyr Leu Asp Asp Arg Phe Ile Asn 530 535 540 Asp Ala Ile Leu Ser Pro Gly Val Lys Arg Ile Leu Arg Glu Ala Thr 545 550 555 560 Lys Val Phe Asn Ala Ile Leu Lys Gin Phe Ser Glu Glu Tyr Asp Val 565 570 575 Thr Lys Val Val Ile Glu Leu Ala Arg Glu Leu Ser Glu Glu Lys Glu 580 585 590 Leu Glu Asn Thr Lys Asn Tyr Lys Lys Leu Ile Lys Lys Asn Gly Asp 595 600 605 Lys Ile Ser Glu Gly Leu Lys Ala Leu Gly Ile Ser Glu Asp Glu Ile 610 615 620 Lys Asp Ile Leu Lys Ser Pro Thr Lys Ser Tyr Lys Phe Leu Leu Trp 625 630 635 640 Leu Gin Gin Asp His Ile Asp Pro Tyr Ser Leu Lys Glu Ile Ala Phe 645 650 655 Asp Asp Ile Phe Thr Lys Thr Glu Lys Phe Glu Ile Asp His Ile Ile Page 2586 of 3790 995 1000 1005 Page 2587 of 3790 1265 1081 226 PRT Mycoplasma iowae Page 2588 of 3790 210 215 220 Thr Pro 225 1082 1304 PRT Mycoplasma synoviae Page 2589 of 3790 Ala Asp Tyr Arg Arg Ala Lys Arg Thr Thr Arg Arg Leu Leu Arg Arg 85 90 95 Lys Lys Phe Lys Arg Glu Lys Phe His Lys Leu Ile Leu Lys Asn Ala 100 105 110 Glu Ile Phe Gly Leu Gin Ser Arg Asn Glu Ile Leu Asn Val Tyr Lys 115 120 125 Asp Gin Ser Ser Lys Tyr Arg Asn Ile Leu Lys Leu Lys Ile Asn Ala 130 135 140 Leu Lys Glu Glu Ile Lys Pro Ser Glu Leu Val Trp Ile Leu Arg Asp 145 150 155 160 Tyr Leu Gin Asn Arg Gly Tyr Phe Tyr Lys Asn Glu Lys Leu Thr Asp 165 170 175 Glu Phe Val Ser Asn Ser Phe Pro Ser Lys Lys Leu His Glu His Tyr 180 185 190 Glu Lys Tyr Gly Phe Phe Arg Gly Ser Val Lys Leu Asp Asn Lys Leu 195 200 205 Asp Asn Lys Lys Asp Lys Ala Lys Glu Lys Asp Glu Glu Glu Glu Ser 210 215 220 Asp Ala Lys Lys Glu Ser Glu Glu Leu Ile Phe Ser Asn Lys Gin Trp 225 230 235 240 Ile Asn Glu Ile Val Lys Val Phe Glu Asn Gin Ser Tyr Leu Thr Glu 245 250 255 Ser Phe Lys Glu Glu Tyr Leu Lys Leu Phe Asn Tyr Val Arg Pro Phe 260 265 270 Asn Lys Gly Pro Gly Ser Lys Asn Ser Arg Thr Ala Tyr Gly Val Phe 275 280 285 Ser Thr Asp Ile Asp Pro Glu Thr Asn Lys Phe Lys Asp Tyr Ser Asn 290 295 300 Ile Trp Asp Lys Thr Ile Gly Lys Cys Ser Leu Phe Glu Glu Glu Ile 305 310 315 320 Arg Ala Pro Lys Asn Leu Pro Ser Ala Leu Ile Phe Asn Leu Gin Asn 325 330 335 Page 2590 of 3790 Glu Ile Cys Thr Ile Lys Asn Glu Phe Thr Glu Phe Lys Asn Trp Trp 340 345 350 Leu Asn Ala Glu Gin Lys Ser Glu Ile Leu Lys Phe Val Phe Thr Glu 355 360 365 Leu Phe Asn Trp Lys Asp Lys Lys Tyr Ser Asp Lys Lys Phe Asn Lys 370 375 380 Asn Leu Gin Asp Lys Ile Lys Lys Tyr Leu Leu Asn Phe Ala Leu Glu 385 390 395 400 Asn Phe Asn Leu Asn Glu Glu Ile Leu Lys Asn Arg Asp Leu Glu Asn 405 410 415 Asp Thr Val Leu Gly Leu Lys Gly Val Lys Tyr Tyr Glu Lys Ser Asn 420 425 430 Ala Thr Ala Asp Ala Ala Leu Glu Phe Ser Ser Leu Lys Pro Leu Tyr 435 440 445 Val Phe Ile Lys Phe Leu Lys Glu Lys Lys Leu Asp Leu Asn Tyr Leu 450 455 460 Leu Gly Leu Glu Asn Thr Glu Ile Leu Tyr Phe Leu Asp Ser Ile Tyr 465 470 475 480 Leu Ala Ile Ser Tyr Ser Ser Asp Leu Lys Glu Arg Asn Glu Trp Phe 485 490 495 Lys Lys Leu Leu Lys Glu Leu Tyr Pro Lys Ile Lys Asn Asn Asn Leu 500 505 510 Glu Ile Ile Glu Asn Val Glu Asp Ile Phe Glu Ile Thr Asp Gin Glu 515 520 525 Lys Phe Glu Ser Phe Ser Lys Thr His Ser Leu Ser Arg Glu Ala Phe 530 535 540 Asn His Ile Ile Pro Leu Leu Leu Ser Asn Asn Glu Gly Lys Asn Tyr 545 550 555 560 Glu Ser Leu Lys His Ser Asn Glu Glu Leu Lys Lys Arg Thr Glu Lys 565 570 575 Ala Glu Leu Lys Ala Gin Gin Asn Gin Lys Tyr Leu Lys Asp Asn Phe Page 2592 of 3790 Page 2593 of 3790 1083 1401 Page 2594 of 3790 PRT Myroides injenensis 1083 Page 2595 of 3790 Glu Asn Lys Gly Ser Arg Asp Glu Lys Lys Lys Gin Ala Leu Gin Trp 245 250 255 Arg Ser Glu Ala Leu Ser Lys Gin Leu Ser Lys Glu Ile Val Ala Tyr 260 265 270 Ile Ile Ala Asp Leu Asn Gly Gin Ile Tyr Asn Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Asn Leu Thr 290 295 300 Val Gly Gin Tyr Leu Phe Lys Gin Leu Lys Ser Asn Pro His Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asn Glu Phe Glu 325 330 335 Lys Ile Trp Glu Thr Gin Ser Lys Phe Tyr Pro Lys Glu Leu Thr Ala 340 345 350 Ala Leu Lys Arg Glu Ile Arg Asp Val Ile Ile Phe Tyr Gin Arg Lys 355 360 365 Leu Lys Ser Gin Lys Gly Leu Ile Ser Phe Cys Glu Phe Glu Gin Lys 370 375 380 Gin Lys Thr Ile Asn Gly Lys Thr Lys Thr Ile Gly His Arg Val Ile 385 390 395 400 Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys Ile Trp Gin Gin Leu 405 410 415 His Asn Val Val Leu Arg Asn Lys Lys Thr Asn Glu Ile Val Ser Leu 420 425 430 Ala Asp Glu Gin Lys Val His Leu Phe Glu Glu Leu Asn Leu Lys Gly 435 440 445 Lys Leu Lys Ser Asn Gin Val Leu Lys Leu Ile Glu Asn Lys Pro Lys 450 455 460 Asp Trp Glu Leu Asn Tyr Thr Glu Leu Glu Gly Asn Asn Thr Asn Lys 465 470 475 480 Ala Leu Tyr Asn Ala Tyr Leu Asp Ile Leu Asp Ile Glu Gly Tyr Asp Page 2597 of 3790 Ile Lys Ile Leu Gin Lys Glu Asp Gly Ile Lys Asn Pro Thr Arg Asn 740 745 750 Asp Ile Val Arg Phe Lys Leu Tyr Ser Glu Leu Lys Asn Asn Gly Tyr 755 760 765 Lys Asp Leu Tyr Thr Asn Glu Tyr Ile Glu Arg Lys Asp Ile Phe Thr 770 775 780 Lys Glu Tyr Asp Ile Glu His Ile Ile Pro Gin Ser Lys Leu Phe Asp 785 790 795 800 Asp Ser Phe Ser Asn Lys Thr Leu Val Arg Arg Asn Val Asn Leu Lys 805 810 815 Lys Gly Asn Gin Thr Ala Tyr Asp Phe Ile Leu Cys Glu Tyr Gly Gin 820 825 830 Glu Lys Ala Asn Glu Phe Glu Thr Arg Ile Thr Asn Leu Tyr Asn Leu 835 840 845 Gly Lys Asp Glu Gly Ile Ser Lys Ser Lys Phe Lys Lys Leu Leu Met 850 855 860 Gin Glu Ser Glu Ile Gly Asn Gly Phe Ile Glu Arg Asp Leu Arg Glu 865 870 875 880 Thr Gin Tyr Ile Ala Lys Lys Ala Lys Ser Leu Leu Leu Glu Ile Thr 885 890 895 Arg Asn Val Ile Ser Thr Ser Gly Ser Ile Thr Asp Arg Leu Arg Glu 900 905 910 Asp Trp Gly Leu Ile Asn Val Met Lys Glu Leu Asn Leu Gin Lys Tyr 915 920 925 Arg Asp Ala Gly Leu Thr Glu Phe Val Lys Met Lys Asp Gly Asn Lys 930 935 940 Lys Glu Val Ile Ile Asp Trp Thr Lys Arg Asn Asp His Arg His His 945 950 955 960 Ala Met Asp Ala Leu Thr Ile Ala Phe Thr Lys His Asn His Ile Gin 965 970 975 Tyr Leu Asn His Leu Asn Ala Arg Lys Asn Val Asn Asn Glu Leu His 980 985 990 Page 2598 of 3790 Asn Asn Ile Ile Ala Ile Glu Lys Leu Glu Thr Thr Leu Val Ser Asp 995 1000 1005 Page 2599 of 3790 Gly Glu Tyr 1400 1084 1466 PRT Myroides odoratus 1084 Met Lys Asn Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Lys Glu Asp Phe Glu Asn Lys Gin Gly Glu Ile Leu Gly 20 25 30 Page 2600 of 3790 Leu Gly Ser Arg Ile Ile Pro Met Ser Gin Asp Ile Leu Gly Glu Phe 35 40 45 Gly Arg Gly Asn Ser Ile Ser Gin Thr Ala Asp Arg Thr Gly Tyr Arg 50 55 60 Gly Val Arg Arg Leu Arg Glu Arg His Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 His Arg Val Leu Asn Ile Leu Gly Phe Leu Pro Asn His Tyr Ala Lys 85 90 95 Glu Ile Asp Phe Thr Lys Arg Leu Gly Lys Phe Ile Asn His Ala Glu 100 105 110 Pro Lys Leu Ser Phe Asp Lys Glu Phe Ile Phe Lys Asp Ser Phe Asn 115 120 125 Glu Met Leu Lys Asp Phe Gin Gin Asn Gin Pro Gly Phe Ile Ile Asn 130 135 140 Lys His Gly Glu Glu Ala Leu Val Pro Tyr Asp Trp Thr Ile Tyr Tyr 145 150 155 160 Leu Arg Lys Lys Ala Leu Thr Gin Lys Ile Asp Lys Glu Glu Leu Ala 165 170 175 Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg Gly Tyr Tyr Gin Leu Arg 180 185 190 Gly Glu Glu Glu Glu Glu Asn Thr Asn Lys Leu Val Glu Phe Tyr Ser 195 200 205 Leu Lys Ile Ile Asp Val Ile Ala Asp Asn Glu Val Asn Lys Lys Gly 210 215 220 Glu Val Trp Tyr Ser Leu His Leu Glu Asn Gly Trp Ile Tyr Arg Arg 225 230 235 240 Ser Ser Lys Ile Ser Leu Val Asp Trp Lys Asp Lys Val Arg Asp Phe 245 250 255 Ile Val Thr Thr Asp Val Asn Asp Asp Gly Ser Glu Lys Leu Asp Lys 260 265 270 Asp Gly Val Val Lys Arg Ser Phe Arg Ala Pro Ser Ala Asp Asp Trp Page 2601 of 3790 275 280 285 Thr Leu Leu Lys Lys Lys Thr Glu Gin Asp Ile Asp Asn Ser Asn Lys 290 295 300 Thr Val Gly Ala Tyr Ile Tyr Glu Asn Leu Leu Leu Asn Pro Lys Gin 305 310 315 320 Lys Ile Lys Gly Lys Leu Val Arg Thr Ile Glu Arg Lys Phe Tyr Lys 325 330 335 Asp Glu Leu Lys Gin Ile Leu Glu Lys Gin Lys Glu Phe His Gin Glu 340 345 350 Leu Gin Asn Glu Gin Leu Leu Gin Asp Cys Val Arg Glu Leu Tyr Lys 355 360 365 Tyr Asn Glu Gin His Gin Gin Met Leu Glu Ser Lys Asp Phe Val His 370 375 380 Leu Phe Leu Asn Asp Ile Ile Phe Tyr Gin Arg Pro Leu Arg Ser Gin 385 390 395 400 Lys Ser Leu Ile Ser Asn Cys Thr Leu Glu Lys Arg Val Ser Arg Asp 405 410 415 Gly Val Val Phe Pro Ile Lys Val Ile Ser Lys Ser Asn Pro Tyr Tyr 420 425 430 Gin Glu Phe Arg Leu Leu Gin Trp Leu Gin Asn Leu Ala Ile Tyr Arg 435 440 445 Lys Asp Asp Asp Val Asn Val Thr Gin Glu Phe Leu Asn Ser Ile Glu 450 455 460 Ser Trp Glu Asn Leu Leu Gin Phe Leu Asn Ala Lys Lys Glu Ile Lys 465 470 475 480 Gin Glu Gin Leu Ile Lys Phe Leu Leu Glu Gin Lys Gly Leu Lys Gly 485 490 495 Asn Ser Leu Lys Thr Ala Ile Leu Thr Tyr Arg Trp Asn Tyr Val Thr 500 505 510 Asp Lys Val Tyr Pro Met Asn Glu Thr Arg Ser Leu Ile Gin Asp Lys 515 520 525 Page 2602 of 3790 Leu Lys Lys Val Glu Asn Val Ala Thr Asp Phe Leu Ser Phe Asp Asn 530 535 540 Glu Met Ala Leu Trp His Ile Ile Tyr Ser Val Asn Asp Lys Ile Glu 545 550 555 560 Tyr Glu Lys Ala Leu Ala Lys Phe Ala Ser Lys His Asn Leu Asp Glu 565 570 575 Ile Ser Phe Val Glu Ser Phe Lys Lys Phe Pro Pro Phe Lys Ser Asp 580 585 590 Tyr Gly Ser Phe Ser Glu Lys Ala Ile Lys Lys Leu Leu Pro Leu Met 595 600 605 Arg Phe Gly Ser Val Trp Asn Lys Asn Asn Ile Val Pro Ser Val Leu 610 615 620 Asp Arg Ile Asp Lys Ile Leu Thr Gly Glu Tyr Asp Glu Lys Ile Lys 625 630 635 640 Ile Arg Val Arg Glu Lys Ala Glu Gin Phe Gin Leu Asn Gin Ile Glu 645 650 655 Asp Phe Gin Asn Leu Pro Leu Trp Leu Ala Gin Tyr Val Val Tyr Asp 660 665 670 Arg His Ser Glu Ala Glu Ile Ala Gly Lys Trp Asn Ser Val Lys Asp 675 680 685 Leu Glu Asn Tyr Leu Lys Glu Phe Lys Gin His Ser Leu Arg Asn Pro 690 695 700 Ile Val Glu Gin Ile Ile Thr Glu Thr Leu Arg Val Val Lys Asp Ile 705 710 715 720 Trp Gin Gin Tyr Gly Asn Gly Val Gin Asn Phe Phe Asp Glu Ile His 725 730 735 Ile Glu Leu Gly Arg Glu Met Lys Asn Thr Ala Asp Glu Arg Lys Arg 740 745 750 Ile Thr Asn Ser Val Thr Glu Asn Glu Asn Thr Asn Leu Arg Ile Lys 755 760 765 Ala Leu Leu Val Glu Leu Lys Glu Asp Thr Asn Ile Glu Asn Val Arg 770 775 780 Page 2603 of 3790 Page 2604 of 3790 Glu Gly Ile Glu Glu Leu Asn Lys Ser Ile Ser Val Tyr Asn Glu 1460 1465 1085 241 PRT Neisseria lactamica 1085 Met Ala Ala Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp Ala Page 2607 of 3790 1086 666 PRT Neisseria lactamica Page 2608 of 3790 Pro His Val Ser Asp Gly Leu Lys Glu Asp Ile Glu Thr Leu Leu Met 225 230 235 240 Ala Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Thr Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Lys Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Cys Lys Lys Asn Ala Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Page 2609 of 3790 660 665 1087 828 PRT Neisseria lactamica Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn 20 25 30 Page 2610 of 3790 Leu Arg Ile Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu 35 40 45 Arg Ala Thr Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr 50 55 60 Ala Gin Ala Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys 65 70 75 80 Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu 85 90 95 Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu 100 105 110 Lys Asp Lys Lys Ser Pro Leu Asn Leu Ser Thr Glu Leu Gin Asp Glu 115 120 125 Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Lys Asp Ile Thr Gly 130 135 140 Arg Leu Lys Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys 145 150 155 160 His Ile Ser Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg 165 170 175 Arg Ile Val Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys 180 185 190 Ala Glu Ile Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys 195 200 205 Ile Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val 210 215 220 Leu Arg Ala Leu Ser Gin Ala Arg Lys Val Ile Asn Ala Val Val Arg 225 230 235 240 Arg Tyr Asp Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val 245 250 255 Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu 260 265 270 Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe 275 280 285 Page 2611 of 3790 Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg 290 295 300 Leu Tyr Glu Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile 305 310 315 320 Asn Leu Val Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala 325 330 335 Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu 340 345 350 Val Leu Gly Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu 355 360 365 Tyr Phe Asn Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala 370 375 380 Arg Val Glu Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu 385 390 395 400 Leu Gin Lys Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp 405 410 415 Thr Arg Tyr Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp His Ile 420 425 430 Leu Leu Thr Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gin 435 440 445 Ile Thr Asn Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala 450 455 460 Glu Asn Asp Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser 465 470 475 480 Thr Val Ala Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu 485 490 495 Met Asn Ala Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val 500 505 510 Leu His Gin Lys Ala His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin 515 520 525 Glu Val Met Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Page 2613 of 3790 820 825 1088 408 PRT Neisseria lactamica Page 2614 of 3790 Page 2615 of 3790 Neisseria meningitidis Page 2616 of 3790 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Page 2617 of 3790 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala Page 2619 of 3790 Asp Ser Phe Asn Phe Lys Phe Ser Leu His Pro Asn Asp Leu Val Glu 995 1000 1005 1090 976 PRT Neisseria meningitidis Page 2620 of 3790 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asp Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Page 2621 of 3790 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Page 2622 of 3790 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gin Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 965 970 975 1091 1081 PRT Neisseria meningitidis Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg Page 2625 of 3790 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Val Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Asp Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Ala Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Page 2626 of 3790 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp His Met Leu Leu Thr 675 680 685 Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asn 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gin Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 885 890 895 Page 2627 of 3790 1092 1081 PRT Neisseria meningitidis Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 20 25 30 Page 2628 of 3790 Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 35 40 45 Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Ala Ala Arg Arg Leu 50 55 60 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 65 70 75 80 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gin Ala Ala Asp 85 90 95 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ser Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asn Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Page 2629 of 3790 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Page 2630 of 3790 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Page 2631 of 3790 Val Gin Leu Lys Lys Asp Ser Phe Leu Gly Tyr Phe Ser Gly Leu 1010 1015 1020 Asp Arg Ala Thr Gly Ala Ile Ser Leu Arg Glu His Asp Leu Glu 1025 1030 1035 Page 2632 of 3790 1093 1082 PRT Neisseria meningitidis Page 2633 of 3790 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val Page 2635 of 3790 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gin Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 885 890 895 Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 900 905 910 Ala Gly Asn Arg Thr Gin Gin Val Lys Ala Val Arg Val Glu Gin Val 915 920 925 Page 2636 of 3790 1094 1082 PRT Neisseria meningitidis Page 2637 of 3790 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 65 70 75 80 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gin Ala Ala Asp 85 90 95 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asp Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Ser Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Page 2638 of 3790 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly Page 2640 of 3790 Page 2641 of 3790 Glu Ile Arg Pro Cys Arg Leu Lys Lys Arg Pro Pro Val Arg 1070 1075 1080 1095 1082 PRT Neisseria meningitidis Page 2642 of 3790 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Ser Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Page 2643 of 3790 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Tyr Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp Page 2645 of 3790 Leu Val Pro Ile Tyr Ser Trp Gin Val Ala Lys Gly Ile Leu Pro Asp 965 970 975 Arg Ala Val Val Gin Gly Lys Asp Glu Glu Asp Trp Gin Leu Ile Asp 980 985 990 Asp Ser Phe Asn Phe Lys Phe Ser Leu His Pro Asn Asp Leu Val Glu 995 1000 1005 1096 1081 PRT Neisseria meningitidis Page 2646 of 3790 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asp Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Lys Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Asn Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Gin Pro Leu Thr Asp Thr Gin Arg Ala Lys 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Page 2647 of 3790 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asn Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Gin Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Page 2648 of 3790 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 980 985 990 Glu Ser Phe Arg Phe Lys Phe Val Leu Tyr Ser Asn Asp Leu Ile Lys 995 1000 1005 1097 1081 PRT Neisseria meningitidis Page 2650 of 3790 Page 2651 of 3790 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Ser Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Thr Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Page 2652 of 3790 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Page 2653 of 3790 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gin Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 885 890 895 Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 900 905 910 Ala Gly Asn Arg Thr Gin Gin Val Lys Ala Val Arg Val Glu Gin Val 915 920 925 Gin Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 930 935 940 Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 945 950 955 960 Leu Val Pro Ile Tyr Ser Trp Gin Val Ala Lys Gly Ile Leu Pro Asp 965 970 975 Arg Ala Val Val Ala Tyr Ala Asp Glu Glu Asp Trp Thr Val Ile Asp 980 985 990 Glu Ser Phe Arg Phe Lys Phe Val Leu Tyr Ser Asn Asp Leu Ile Lys Page 2654 of 3790 995 1000 1005 1098 1082 PRT Neisseria meningitidis Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg Page 2656 of 3790 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Page 2657 of 3790 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp His Ile Leu Leu Thr 675 680 685 Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gin Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 885 890 895 Page 2658 of 3790 1099 1081 PRT Neisseria meningitidis Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 20 25 30 Page 2659 of 3790 Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 35 40 45 Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 50 55 60 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 65 70 75 80 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gin Ala Ala Asp 85 90 95 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asp Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Page 2660 of 3790 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Glu Ile Tyr Leu 450 455 460 Pro Pro Ile Thr Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Ala Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Page 2661 of 3790 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Glu Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu His Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Ile Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Ala His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Page 2662 of 3790 Val Gin Leu Lys Lys Asp Ser Phe Leu Gly Tyr Phe Ser Gly Leu 1010 1015 1020 Asp Arg Ala Thr Gly Ala Ile Ser Leu Arg Glu His Asp Leu Glu 1025 1030 1035 Page 2663 of 3790 1100 1082 PRT Neisseria meningitidis Page 2664 of 3790 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val Page 2666 of 3790 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp His Ile Leu Leu Thr 675 680 685 Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Lys Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Ala His Lys Asp Thr Leu Arg Ser 835 840 845 Ala Lys Arg Phe Val Lys His Asn Glu Lys Ile Ser Val Lys Arg Val 850 855 860 Trp Leu Thr Glu Ile Lys Leu Ala Asp Leu Glu Asn Met Val Asn Tyr 865 870 875 880 Lys Asn Gly Arg Glu Ile Glu Leu Tyr Glu Ala Leu Lys Ala Arg Leu 885 890 895 Glu Ala Tyr Gly Gly Asn Ala Lys Gin Ala Phe Asp Pro Lys Asp Asn 900 905 910 Pro Phe Tyr Lys Lys Gly Gly Gin Leu Val Lys Ala Val Arg Val Glu 915 920 925 Page 2667 of 3790 1070 1075 1080 1101 1082 PRT 55 60 Page 2668 of 3790 Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 65 70 75 80 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gin Ala Ala Asp 85 90 95 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asn Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Page 2669 of 3790 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Ser Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val Page 2671 of 3790 Page 2672 of 3790 Glu Ile Arg Pro Cys Arg Leu Lys Lys Arg Pro Pro Val Arg 1070 1075 1080 1102 1082 PRT Neisseria meningitidis Page 2673 of 3790 Gin Ala Glu Leu Asn Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Ile Ser Asp Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Thr Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Thr Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Glu Leu Asp Asp Ile Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Asn 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Asp Leu 450 455 460 Page 2674 of 3790 Pro Pro Ile Pro Ala Asp Glu Ile His Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp Page 2676 of 3790 Leu Val Pro Ile Tyr Ser Trp Gin Val Ala Lys Gly Ile Leu Pro Asp 965 970 975 Arg Ala Val Val Gin Gly Lys Asp Glu Glu Asp Trp Gin Leu Ile Asp 980 985 990 Asp Ser Phe Asn Phe Lys Phe Ser Leu His Pro Asn Asp Leu Val Glu 995 1000 1005 1103 1082 PRT Neisseria meningitidis Page 2677 of 3790 Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gin 100 105 110 Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 115 120 125 Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 145 150 155 160 Gly Val Ala Asp Asn Ala His Ala Leu Gin Thr Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 195 200 205 Gin Ala Glu Leu Ile Leu Leu Phe Glu Lys Gin Lys Glu Phe Gly Asn 210 215 220 Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 225 230 235 240 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Page 2678 of 3790 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Arg Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Val Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Ala Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Page 2679 of 3790 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 Page 2680 of 3790 860 1104 1082 PRT Neisseria meningitidis Page 2681 of 3790 Page 2682 of 3790 Thr Gin Arg Pro Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 275 280 285 Leu Glu Gin Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 290 295 300 Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gin Ala 305 310 315 320 Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 325 330 335 Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 340 345 350 Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 355 360 365 Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gin Asp Glu Ile Gly Thr 370 375 380 Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 385 390 395 400 Asp Arg Ile Gin Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 405 410 415 Phe Asp Lys Phe Val Gin Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 420 425 430 Pro Leu Met Glu Gin Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 435 440 445 Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 450 455 460 Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 465 470 475 480 Leu Ser Gin Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 485 490 495 Page 2683 of 3790 Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 500 505 510 Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gin Glu Glu Asn Arg Lys 515 520 525 Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 530 535 540 Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 565 570 575 Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 580 585 590 Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 595 600 605 Ser Glu Asn Gin Asn Lys Gly Asn Gin Thr Pro Tyr Glu Tyr Phe Asn 610 615 620 Gly Lys Asp Asn Ser Arg Glu Trp Gin Glu Phe Lys Ala Arg Val Glu 625 630 635 640 Thr Ser Arg Phe Pro Arg Ser Lys Lys Gin Arg Ile Leu Leu Gin Lys 645 650 655 Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 660 665 670 Val Asn Arg Phe Leu Cys Gin Phe Val Ala Asp Arg Met Arg Leu Thr 675 680 685 Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gin Ile Thr Asn 690 695 700 Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 705 710 715 720 Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 725 730 735 Met Gin Gin Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 740 745 750 Page 2684 of 3790 Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gin 755 760 765 Lys Thr His Phe Pro Gin Pro Trp Glu Phe Phe Ala Gin Glu Val Met 770 775 780 Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 785 790 795 800 Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 805 810 815 Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 820 825 830 Ala Pro Asn Arg Lys Met Ser Gly Gin Gly His Met Glu Thr Val Lys 835 840 845 Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 850 855 860 Thr Gin Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 865 870 875 880 Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 885 890 895 Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 900 905 910 Ala Gly Asn Arg Thr Gin Gin Val Lys Ala Val Arg Val Glu Gin Val 915 920 925 Gin Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 930 935 940 Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 945 950 955 960 Leu Val Pro Ile Tyr Ser Trp Gin Val Ala Lys Gly Ile Leu Pro Asp 965 970 975 Arg Ala Val Val Gin Gly Lys Asp Glu Glu Asp Trp Gin Leu Ile Asp 980 985 990 Asp Ser Phe Asn Phe Lys Phe Ser Leu His Pro Asn Asp Leu Val Glu Page 2685 of 3790 995 1000 1005 1105 67 PRT Neisseria meningitidis 1105 25 30 Page 2686 of 3790 210 215 220 1107 392 PRT Neisseria sp. Ile Gly Ile Ala Ser Val Gly Trp Ala Val Val Glu Thr Asp Ser Asp 20 25 30 Page 2687 of 3790 Val Leu Pro Tyr Arg Leu Ile Asp Val Gly Val Arg Thr Phe Asp Arg 35 40 45 Ala Glu Val Pro Lys Thr Gly Glu Ser Pro Ala Ala Ala Arg Arg Leu 50 55 60 Ala Arg Ser Val Arg Arg Met Ile Arg Arg Arg Ala His Arg Met Leu 65 70 75 80 Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Met Leu Gin Ala Ala Asp 85 90 95 Phe Asp Ala His Gly Leu Val Glu Asn Leu Pro Val Asn Pro Trp Gin 100 105 110 Leu Arg Val Asp Ala Leu Ser Arg Lys Leu Met Pro Leu Glu Trp Ala 115 120 125 Ala Val Leu Leu His Met Val Lys His Arg Gly Tyr Leu Ser Gin Arg 130 135 140 Lys Asn Glu Arg Asn Ser Ser Asp Lys Glu Leu Gly Ala Leu Leu Ser 145 150 155 160 Gly Val Ala Ala Asn Ser Glu Ala Leu Gin Gly Gly Asp Phe Arg Thr 165 170 175 Pro Ala Glu Leu Ala Val Asn Lys Phe Glu Lys Glu Ser Gly His Ile 180 185 190 Arg Asn Gin Arg Gly Asp Tyr Ser His Thr Phe Asn Arg Lys Asp Val 195 200 205 Gin Ala Glu Leu Val Leu Leu Phe Glu Lys Gin Lys Glu Tyr Gly Asn 210 215 220 Pro Tyr Ile Ser Asp Gly Leu Leu Thr Gly Val Glu Asp Leu Leu Met 225 230 235 240 Thr Gin Arg Ala Ala Leu Ser Gly Asp Ala Val Gin Lys Met Leu Gly 245 250 255 Arg Cys Thr Phe Glu Pro Glu Glu Tyr Lys Ala Ala Lys Asn Thr Tyr 260 265 270 Ser Ala Glu Arg Phe Val Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Page 2688 of 3790 275 280 285 1108 701 PRT Neisseria sp. 1108 90 95 Asn Pro Val Val Leu Arg Ala Leu Ser Gin Ala Arg Lys Val Val Asn Page 2690 of 3790 Cys Ser Thr Val Ala Met Gin Gin Lys Ile Thr Asn Tyr Val Arg Gin 355 360 365 Lys Glu Met Asn Val Phe Asp Gly Glu Met Val Asp Lys Thr Thr Gly 370 375 380 Glu Val Ser Arg Leu His Phe Pro Gin Pro Trp Asp Phe Phe Arg Gin 385 390 395 400 Glu Val Met Met Arg Val Phe Gly Lys Pro Asp Thr Pro Ser Glu Asn 405 410 415 Asn Glu Glu Ala Asp Thr Pro Glu Lys Leu Arg Ala Leu Leu Ala Asp 420 425 430 Lys Leu Ser Ser Arg Pro Glu Ala Val His Glu Ala Val Thr Pro Leu 435 440 445 Phe Val Ser Arg Ala Pro Ser Arg Lys Met Ser Gly Gin Gly His Met 450 455 460 Glu Thr Ile Lys Ser Ala Lys Arg Leu Ser Glu Gly Lys Ser Val Leu 465 470 475 480 Arg Val Pro Leu Thr Gin Leu Thr Pro Lys Leu Leu Glu Asn Met Val 485 490 495 Asn Arg Glu Arg Glu Pro Gin Leu Tyr Glu Asp Leu Leu Gly Arg Leu 500 505 510 Asn Ala His Gly Gly Asp Pro Ala Lys Ala Phe Ala Ala Pro Phe Phe 515 520 525 Lys Arg Asp Lys Ala Gly Asn Pro Thr Gin Gin Val Lys Ala Val Arg 530 535 540 Val Glu Asp Val Gin Lys Ser Gly Val Ile Val Arg Glu Gly Asn Gly 545 550 555 560 Val Ala Asp Asn Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly 565 570 575 Gly Lys Tyr Tyr Leu Met Pro Ile Tyr Thr Trp Gin Ala Ala Lys Gly 580 585 590 Ile Leu Pro Asn Lys Ala Val Ile Ala His Thr Asp Glu Ala Asn Trp 595 600 605 Page 2691 of 3790 690 695 700 1109 1089 PRT Neisseria sp. Page 2692 of 3790 Leu Thr Pro Leu Glu Trp Ala Ala Val Leu Leu His Leu Val Lys His 130 135 140 Arg Gly Tyr Leu Ser Gin Arg Lys Asn Glu Gly Glu Thr Asp Asp Lys 145 150 155 160 Glu Leu Gly Ala Leu Leu Lys Gly Val Ala Asp Asn Thr His Ala Leu 165 170 175 Gin Ala Gly Asn Phe Arg Thr Pro Ala Glu Leu Ala Leu Asn Lys Phe 180 185 190 Glu Lys Glu Ser Gly His Ile Arg Asn Gin Arg Gly Asp Tyr Ser His 195 200 205 Thr Phe Ser Arg Lys Asp Leu Gin Ala Glu Leu Val Leu Leu Phe Glu 210 215 220 Lys Gin Lys Glu Phe Gly Asn Pro Tyr Val Ser Asp Asp Leu Lys Asn 225 230 235 240 Gly Ile Glu Asn Leu Leu Met Thr Gin Arg Pro Ala Leu Ser Gly Asp 245 250 255 Ala Ile Gin Lys Met Leu Gly His Cys Thr Phe Glu Pro Ala Glu Pro 260 265 270 Lys Ala Ala Lys Asn Thr Tyr Thr Ala Glu Arg Phe Ile Trp Leu Thr 275 280 285 Lys Leu Asn Asn Leu Arg Ile Leu Asn Gin Gly Asn Glu Arg Pro Leu 290 295 300 Thr Asp Ala Glu Arg Thr Thr Leu Met Asp Glu Pro Tyr Lys Lys Ser 305 310 315 320 Lys Leu Thr Tyr Ala Gin Ala Arg Lys Leu Leu Asp Leu Asp Asp Thr 325 330 335 Ala Phe Phe Lys Gly Leu Arg Tyr Gly Lys Asp Asn Ala Glu Ser Ala 340 345 350 Thr Leu Met Glu Met Lys Ala Tyr His Ala Ile Ser Arg Ala Leu Glu 355 360 365 Lys Glu Gly Leu Lys Asp Lys Lys Ser Pro Leu Ser Leu Ser Pro Glu 370 375 380 Page 2693 of 3790 Leu Gin Asp Glu Ile Gly Thr Ala Phe Ser Leu Phe Lys Thr Asp Glu 385 390 395 400 Glu Ile Thr Gly Arg Leu Lys Gly Cys Leu Gin Pro Glu Ile Leu Asp 405 410 415 Ala Leu Leu Lys His Ile Ser Phe Asp Lys Phe Val Gin Ile Ser Leu 420 425 430 Lys Ala Leu Arg Arg Ile Val Pro Leu Met Glu Gin Gly Lys Arg Tyr 435 440 445 Asp Glu Ala Cys Ala Glu Ile Tyr Gly Asp His His Gly Arg Arg Asn 450 455 460 Ser Glu Glu Thr Leu Tyr Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg 465 470 475 480 Asn Pro Val Val Leu Arg Ala Leu Ser Gin Ala Arg Lys Val Ile Asn 485 490 495 Gly Val Gly Arg Arg Tyr Gly Ser Pro Ala Arg Ile His Ile Glu Thr 500 505 510 Ala Arg Glu Val Gly Lys Ser Phe Lys Asp Arg Lys Glu Ile Glu Lys 515 520 525 Arg Gin Glu Glu Asn Arg Lys Asp Arg Glu Lys Ala Ala Ala Glu Phe 530 535 540 Gin Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys Ser Lys Asp Ile 545 550 555 560 Leu Lys Leu Arg Leu Tyr Arg Gin Gin Asn Cys Lys Cys Leu Tyr Ser 565 570 575 Gly Lys Glu Ile Asn Leu Gly Arg Leu Asn Glu Lys Gly Tyr Val Glu 580 585 590 Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe Asn 595 600 605 Asn Lys Val Leu Val Leu Gly Ser Glu Asn Gin Asn Lys Gly Asn Arg 610 615 620 Thr Pro Tyr Glu Tyr Leu Asn Gly Lys Asp Asn Ser Arg Glu Trp Gin Page 2695 of 3790 1085 1110 1097 PRT Neisseria wadsworthii 1110 Page 2696 of 3790 Met Lys Lys Gin Pro Gin Arg Tyr Ile Leu Gly Leu Asp Leu Gly Ile 15 10 15 Ala Ser Val Gly Trp Ala Leu Ile Leu Val Asp Gly Ala Glu Asn Pro 20 25 30 Val Gly Leu Leu Asp Cys Gly Val Arg Thr Phe Glu Arg Ala Glu Val 35 40 45 Pro Lys Thr Gly Asp Ser Leu Ala Leu Ala Arg Arg Gin Ala Arg Ser 50 55 60 Val Arg Arg Leu Ile Arg Arg Arg Ala His Arg Leu Leu Arg Leu Arg 65 70 75 80 Arg Leu Leu Lys Arg Glu Gly Ile Leu Ser Ala Ala Asp Phe Asn Ser 85 90 95 Asp Gly Leu Pro Asn Leu Pro Ile Asp Ala Trp Gin Leu Arg Val Ala 100 105 110 Gly Leu Glu Arg Lys Leu Thr Asn Gin Glu Trp Ala Ala Val Leu Leu 115 120 125 His Leu Val Lys His Arg Gly Tyr Leu Ser Gin Arg Lys Ser Glu Thr 130 135 140 Gin Thr Glu Asn Lys Glu Leu Gly Arg Leu Leu Ala Gly Val Ala Glu 145 150 155 160 Asn Ser Lys Leu Leu Ser Glu Ser Ser Glu Gin Tyr Arg Thr Pro Ala 165 170 175 Glu Leu Ala Val Lys Leu Phe Ala Glu Gin Ser Gly His Leu Arg Asn 180 185 190 Lys Gly Gly Glu Tyr Thr His Thr Phe Asn Arg Leu Asp Leu Gin Lys 195 200 205 Glu Leu His Leu Leu Phe Glu Arg Gin Tyr Ala Leu Gly Asn Pro Phe 210 215 220 Ala Ser Ala Glu Leu Gin Ser Lys Val Asp Glu Leu Leu Met Thr Gin 225 230 235 240 Arg Ser Ala Leu Gin Gly Glu Ala Val Leu Lys Met Leu Gly Lys Cys 245 250 255 Page 2697 of 3790 Thr Phe Glu Pro Ser Glu Tyr Lys Ala Ala Lys Asn Thr Tyr Ser Ala 260 265 270 Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile Leu Tyr 275 280 285 Asn Gly Glu Glu Arg Ala Leu Asp Glu Gly Asp Arg Lys Lys Leu Leu 290 295 300 Asp Glu Pro Tyr Lys Lys Ala Lys Leu Thr Tyr Lys Gin Val Arg Ser 305 310 315 320 Ile Leu Asn Leu Pro Glu Ser Ala Val Phe Lys Gly Leu Arg Tyr Gly 325 330 335 Lys Asp Ser Asp Gly Leu Lys Ala Glu Asn Gly Thr Leu Met Glu Met 340 345 350 Lys Ala Tyr His Lys Ile Arg Thr Ile Leu Asp Lys Ala Gly Leu Lys 355 360 365 Gly Glu Trp Glu Asn Arg Ile Arg Asn Pro Glu Ile Leu Asp Lys Ile 370 375 380 Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp Glu Asp Ile Gin Ala Ala 385 390 395 400 Leu Ala Asp Leu Arg Leu Pro Glu Asn Val Leu Asp Ala Leu Leu Ala 405 410 415 Gly Leu Asn Phe Asp Lys Phe Ile Gin Leu Ser Leu Lys Ala Leu Arg 420 425 430 Asn Ile Leu Pro Leu Met Glu Arg Gly Ile Arg Tyr Asp Glu Ala Cys 435 440 445 Lys Glu Val Tyr Gly Asp His Arg Ala Leu Ala Glu Ser Lys Asn Gin 450 455 460 Val Leu Leu Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val 465 470 475 480 Leu Arg Thr Leu Thr Gin Ala Arg Lys Val Ile Asn Ala Ile Ile Arg 485 490 495 Arg Tyr Gly Ser Pro Gin Arg Val His Ile Glu Thr Ala Arg Glu Leu 500 505 510 Page 2698 of 3790 Gly Lys Ser Lys Gin Glu Arg Asp Lys Ile Asp Arg Lys Asn Lys Glu 515 520 525 Asn Gin Asn Asp Arg Asn Arg Leu Ala Ser Asp Ile Arg Lys His Phe 530 535 540 Asn Phe Glu Pro Thr Pro Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 545 550 555 560 Gin Gin His Gly Lys Cys Leu Tyr Ser Asp Leu Arg Glu Glu Lys Gly 565 570 575 Glu Cys Leu Tyr Thr Gly Asn Val Ile Glu Leu His Arg Leu Phe Glu 580 585 590 Asp Gly Tyr Val Glu Ile Asp His Ala Leu Pro Leu Ser Arg Thr Trp 595 600 605 Asp Asn Ser Leu Asn Asn Lys Val Leu Val Leu Lys Ser Ser Asn Gin 610 615 620 Asn Lys Gly Asn Lys Thr Pro Tyr Glu Trp Leu Asp Gly Ala Asn Asn 625 630 635 640 Ser Arg Arg Trp Arg Glu Phe Gin Ala Arg Val Gin Gly Cys His Phe 645 650 655 Pro Tyr Val Lys Lys Gin Arg Ile Gin Thr Ala Lys Leu Asp Ser Lys 660 665 670 Ala Glu Gin Gly Phe Leu Glu Arg Asn Leu Asn Asp Thr Arg Tyr Ile 675 680 685 Ser Lys Phe Met Cys Gin Phe Ile Thr Ala Asn Leu Arg Leu Ala Glu 690 695 700 Thr Ser Asn Ala Leu Met Glu Glu Val Ala Gly Glu Asn Pro Tyr Trp 705 710 715 720 Lys Glu Arg Lys Arg Gin Arg Val Phe Ala Pro Ser Gly Ser Ile Ile 725 730 735 Ala Leu Leu Arg Gly Leu Trp Gly Leu Lys Lys Val Arg Glu Asp Asn 740 745 750 Asp Arg His His Ala Leu Asp Ala Ile Val Val Ala Cys Ser Thr Val Page 2699 of 3790 Lys Ala Glu Lys Arg Thr Ala Leu Asn Gly Lys Lys Lys Lys 1085 1090 1095 Arg Ala Leu Ala Ala Thr Ala Glu Ile Pro Leu Glu Ala Phe Val Arg 115 120 125 Page 2701 of 3790 Val Leu Leu Ala Ile Asn Lys Lys Arg Gly Tyr Lys Ser Ser Arg Lys 130 135 140 Ala Lys Asn Glu Asp Glu Gly Gin Leu Ile Asp Gly Met Ala Ile Ala 145 150 155 160 Arg Arg Leu Tyr Glu Glu Ser Leu Thr Pro Gly Gin Phe Ser Tyr Gin 165 170 175 Leu Leu Lys Glu Gly Lys Lys Tyr Leu Pro Asp Phe Tyr Arg Ser Asp 180 185 190 Leu Asn Thr Glu Leu Asn Lys Val Trp Asn Phe Gin Lys Gin Phe Tyr 195 200 205 Pro Glu Ile Leu Thr Asp Glu Phe Lys Arg His Leu Glu Gly Lys Gly 210 215 220 Gin Arg Ala Thr Ala Val Ala Phe Trp Gly Gin His Gly Phe Ser Met 225 230 235 240 Ala Glu Asn Lys Gly Ser Arg Glu Glu Lys Lys Leu His Ala Tyr Lys 245 250 255 Trp Arg Ser Glu Ala Ala His Lys Gin Leu Thr Lys Glu Glu Val Ala 260 265 270 Phe Val Ile Thr Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr 275 280 285 Leu Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Phe Phe Asn Lys Gin 290 295 300 Thr Val Gly Gin Tyr Leu His Gin Gin Leu Lys Glu Asn Pro His Thr 305 310 315 320 Arg Leu Lys Gly Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe 325 330 335 Glu Thr Ile Trp Glu Met Gin Ala Lys Phe Tyr Ser Ala Leu Thr Leu 340 345 350 Glu Leu Lys Glu Glu Val Arg Asp Val Val Ile Phe Tyr Gin Arg Lys 355 360 365 Leu Lys Ser Gin Met Gly Leu Ile Ser Leu Cys Glu Phe Glu Ser Lys 370 375 380 Page 2702 of 3790 Glu Ile Glu Ile Glu Lys Asn Gly Glu Lys Ala Lys Lys Arg Ile Gly 385 390 395 400 Leu Arg Val Ala Pro Lys Ser Ser Pro Leu Phe Gin Glu Phe Lys Ile 405 410 415 Trp Gin Val Leu Asn Asn Leu Glu Phe Arg Asn Lys Lys Thr Lys Glu 420 425 430 Val Phe Val Pro Glu Met Ala Ala Lys Gin Gin Leu Phe Asp Glu Leu 435 440 445 Asn Ile Lys Gly Asn Leu Leu Ala Ser Glu Ala Ile Lys Ile Leu Gly 450 455 460 Tyr Lys Thr Lys Asp Trp Glu Ala Asn Tyr His Thr Leu Glu Gly Asn 465 470 475 480 Arg Thr Asn Lys Ser Leu Tyr Asp Ala Trp Leu Lys Ile Leu Glu Leu 485 490 495 Glu Gly Tyr Asp Glu Asn Leu Leu Lys Leu Ser Gly Ser Asp Asp Ile 500 505 510 Asp Val Ser Lys Ile Glu Lys Pro Ala Leu Glu Ile Arg Gin Met Val 515 520 525 Leu Ala Val Phe Glu Val Leu Gly Ile Ser Gly Ala Ile Leu Asp Phe 530 535 540 Asp Ala Glu Ala Asp Gly Lys Ala Phe Glu Gin Gin Pro Ala Tyr Gin 545 550 555 560 Leu Trp His Leu Leu Tyr Ser Ala Glu Asp Asp Gly Lys Lys Tyr Ser 565 570 575 Gin Glu Asp Ile Phe Thr Tyr Gly His Asp Asn Ile Gly Leu Lys Lys 580 585 590 Lys Leu Cys Glu Lys Phe Gly Phe Arg Pro Glu His Thr Lys Ile Leu 595 600 605 Val Asn Val Val Phe Ser Asp Asp Tyr Gly Asn Leu Ser Ser Lys Ala 610 615 620 Met Arg Arg Ile Tyr Pro Phe Ile Lys Glu Leu Thr Tyr Asp Lys Ala 625 630 635 640 Page 2703 of 3790 Cys Ala Glu Ala Gly Tyr Arg His Ser Ala Ala Ser Leu Thr Lys Glu 645 650 655 Glu Ile Ala Ala Arg Pro Leu Gin Asn Arg Leu Asp Leu Leu Lys Lys 660 665 670 Asn Glu Leu Arg Ser Pro Val Val Glu Lys Ile Leu Asn Gin Met Val 675 680 685 Asn Val Val Asn Thr Leu Val Asp Asp Glu Asn Gin Asn Arg Lys Ala 690 695 700 Arg Gly Leu Ser Glu Asp Phe His Phe Asp Glu Ile Arg Ile Glu Leu 705 710 715 720 Ala Arg Glu Leu Lys Lys Asn Ala Lys Glu Arg Ala Glu Met Thr Thr 725 730 735 Asn Ile Asn Thr Ala Lys Gin Ser His Glu Lys Ile Ile Arg Ile Leu 740 745 750 Gin Thr Glu Phe Gly Val Pro Asn Pro Ser Arg Asn Asp Ile Val Arg 755 760 765 Tyr Lys Leu Tyr Glu Glu Leu Lys Asn Asn Gly Tyr Lys Asp Leu Tyr 770 775 780 Thr Asn Thr Tyr Ile Ser Arg Asp Ile Leu Phe Ser Lys Gin Ile Asp 785 790 795 800 Val Asp His Ile Ile Pro Gin Met Ser Leu Phe Asp Asp Ser Phe Ser 805 810 815 Asn Lys Thr Val Val Phe Arg Lys Asp Asn Gin Asp Lys Gly Asn Lys 820 825 830 Thr Ala Tyr Asp Tyr Ile Leu Gly Lys Tyr Gly Glu Gin Ala Leu Glu 835 840 845 Glu Tyr Ile Ser Arg Ile Thr Ser Leu Phe Glu Leu Gly Lys Lys Asn 850 855 860 Lys Glu Glu Gly Ile Gly Lys Ala Lys Phe Gin Lys Leu Gin Lys Arg 865 870 875 880 Leu Val Asp Ile Gly Asp Gly Phe Ile Glu Arg Asp Leu Arg Glu Ser 885 895 Page 2704 of 3790 890 Page 2705 of 3790 Page 2706 of 3790 1112 79 PRT Nitritalea halalkaliphila 1112 Page 2707 of 3790 Glu Glu Ser Arg Asn Ala Thr Arg Arg Ala Lys Arg Gin Met Arg Arg 50 55 60 Gin Tyr Phe Arg Lys Lys Leu Arg Lys Ala Lys Leu Leu Glu Leu Leu 65 70 75 80 Ile Ala Tyr Asp Met Cys Pro Leu Lys Pro Glu Asp Val Arg Arg Trp 85 90 95 Lys Asn Trp Asp Lys Gin Gin Lys Ser Thr Val Arg Gin Phe Pro Asp 100 105 110 Thr Pro Ala Phe Arg Glu Trp Leu Lys Gin Asn Pro Tyr Glu Leu Arg 115 120 125 Lys Gin Ala Val Thr Glu Asp Val Thr Arg Pro Glu Leu Gly Arg Ile 130 135 140 Leu Tyr Gin Met Ile Gin Arg Arg Gly Phe Leu Ser Ser Arg Lys Gly 145 150 155 160 Lys Glu Glu Gly Lys Ile Phe Thr Gly Lys Asp Arg Met Val Gly Ile 165 170 175 Asp Glu Thr Arg Lys Asn Leu Gin Lys Gin Thr Leu Gly Ala Tyr Leu 180 185 190 Tyr Asp Ile Ala Pro Lys Asn Gly Glu Lys Tyr Arg Phe Arg Thr Glu 195 200 205 Arg Val Arg Ala Arg Tyr Thr Leu Arg Asp Met Tyr Ile Arg Glu Phe 210 215 220 Glu Ile Ile Trp Gin Arg Gin Ala Gly His Leu Gly Leu Ala His Glu 225 230 235 240 Gin Ala Thr Arg Lys Lys Asn Ile Phe Leu Glu Gly Ser Ala Thr Asn 245 250 255 Val Arg Asn Ser Lys Leu Ile Thr His Leu Gin Ala Lys Tyr Gly Arg 260 265 270 Gly His Val Leu Ile Glu Asp Thr Arg Ile Thr Val Thr Phe Gin Leu 275 280 285 Pro Leu Lys Glu Val Leu Gly Gly Lys Ile Glu Ile Glu Glu Glu Gin 290 295 300 Page 2708 of 3790 Leu Lys Phe Lys Ser Asn Glu Ser Val Leu Phe Trp Gin Arg Pro Leu 305 310 315 320 Arg Ser Gin Lys Ser Leu Leu Ser Lys Cys Val Phe Glu Gly Arg Asn 325 330 335 Phe Tyr Asp Pro Val His Gin Lys Trp Ile Ile Ala Gly Pro Thr Pro 340 345 350 Ala Pro Leu Ser His Pro Glu Phe Glu Glu Phe Arg Ala Tyr Gin Phe 355 360 365 Ile Asn Asn Ile Ile Tyr Gly Lys Asn Glu His Leu Thr Ala Ile Gin 370 375 380 Arg Glu Ala Val Phe Glu Leu Met Cys Thr Glu Ser Lys Asp Phe Asn 385 390 395 400 Phe Glu Lys Ile Pro Lys His Leu Lys Leu Phe Glu Lys Phe Asn Phe 405 410 415 Asp Asp Thr Thr Lys Val Pro Ala Cys Thr Thr Ile Ser Gin Leu Arg 420 425 430 Lys Leu Phe Pro His Pro Val Trp Glu Glu Lys Arg Glu Glu Ile Trp 435 440 445 His Cys Phe Tyr Phe Tyr Asp Asp Asn Thr Leu Leu Phe Glu Lys Leu 450 455 460 Gin Lys Asp Tyr Ala Leu Gin Thr Asn Asp Leu Glu Lys Ile Lys Lys 465 470 475 480 Ile Arg Leu Ser Glu Ser Tyr Gly Asn Val Ser Leu Lys Ala Ile Arg 485 490 495 Arg Ile Asn Pro Tyr Leu Lys Lys Gly Tyr Ala Tyr Ser Thr Ala Val 500 505 510 Leu Leu Gly Gly Ile Arg Asn Ser Phe Gly Lys Arg Phe Glu Tyr Phe 515 520 525 Lys Glu Tyr Glu Pro Glu Ile Glu Lys Ala Val Cys Arg Ile Leu Lys 530 535 540 Glu Lys Asn Ala Glu Gly Glu Val Ile Arg Lys Ile Lys Asp Tyr Leu 545 550 555 560 Page 2709 of 3790 Val His Asn Arg Phe Gly Phe Ala Lys Asn Asp Arg Ala Phe Gin Lys 565 570 575 Leu Tyr His His Ser Gin Ala Ile Thr Thr Gin Ala Gin Lys Glu Arg 580 585 590 Leu Pro Glu Thr Gly Asn Leu Arg Asn Pro Ile Val Gin Gin Gly Leu 595 600 605 Asn Glu Leu Arg Arg Thr Val Asn Lys Leu Leu Ala Thr Cys Arg Glu 610 615 620 Lys Tyr Gly Pro Ser Phe Lys Phe Asp His Ile His Val Glu Met Gly 625 630 635 640 Arg Glu Leu Arg Ser Ser Lys Thr Glu Arg Glu Lys Gin Ser Arg Gin 645 650 655 Ile Arg Glu Asn Glu Lys Lys Asn Glu Ala Ala Lys Val Lys Leu Ala 660 665 670 Glu Tyr Gly Leu Lys Ala Tyr Arg Asp Asn Ile Gin Lys Tyr Leu Leu 675 680 685 Tyr Lys Glu Ile Glu Glu Lys Gly Gly Thr Val Cys Cys Pro Tyr Thr 690 695 700 Gly Lys Thr Leu Asn Ile Ser His Thr Leu Gly Ser Asp Asn Ser Val 705 710 715 720 Gin Ile Glu His Ile Ile Pro Tyr Ser Ile Ser Leu Asp Asp Ser Leu 725 730 735 Ala Asn Lys Thr Leu Cys Asp Ala Thr Phe Asn Arg Glu Lys Gly Glu 740 745 750 Leu Thr Pro Tyr Asp Phe Tyr Gin Lys Asp Pro Ser Pro Glu Lys Trp 755 760 765 Gly Ala Ser Ser Trp Glu Glu Ile Glu Asp Arg Ala Phe Arg Leu Leu 770 775 780 Pro Tyr Ala Lys Ala Gin Arg Phe Ile Arg Arg Lys Pro Gin Glu Ser 785 790 795 800 Asn Glu Phe Ile Ser Arg Gin Leu Asn Asp Thr Arg Tyr Ile Ser Lys 805 815 Page 2710 of 3790 810 Cys Thr Leu Asp Thr Asp Thr Ala Gin Pro Ala Phe Thr Pro Ile 1040 1045 1050 Page 2711 of 3790 Page 2712 of 3790 1114 1389 PRT Oenococcus kitaharae 1114 Page 2713 of 3790 Met Ala Arg Asp Tyr Ser Val Gly Leu Asp Ile Gly Thr Ser Ser Val 15 10 15 Gly Trp Ala Ala Ile Asp Asn Lys Tyr His Leu Ile Arg Ala Lys Ser 20 25 30 Lys Asn Leu Ile Gly Val Arg Leu Phe Asp Ser Ala Val Thr Ala Glu 35 40 45 Lys Arg Arg Gly Tyr Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg His 50 55 60 Trp Arg Leu Arg Leu Leu Asn Asp Ile Phe Ala Gly Pro Leu Thr Asp 65 70 75 80 Phe Gly Asp Glu Asn Phe Leu Ala Arg Leu Lys Tyr Ser Trp Val His 85 90 95 Pro Gin Asp Gin Ser Asn Gin Ala His Phe Ala Ala Gly Leu Leu Phe 100 105 110 Asp Ser Lys Glu Gin Asp Lys Asp Phe Tyr Arg Lys Tyr Pro Thr Ile 115 120 125 Tyr His Leu Arg Leu Ala Leu Met Asn Asp Asp Gin Lys His Asp Leu 130 135 140 Arg Glu Val Tyr Leu Ala Ile His His Leu Val Lys Tyr Arg Gly His 145 150 155 160 Phe Leu Ile Glu Gly Asp Val Lys Ala Asp Ser Ala Phe Asp Val His 165 170 175 Thr Phe Ala Asp Ala Ile Gin Arg Tyr Ala Glu Ser Asn Asn Ser Asp 180 185 190 Glu Asn Leu Leu Gly Lys Ile Asp Glu Lys Lys Leu Ser Ala Ala Leu 195 200 205 Thr Asp Lys His Gly Ser Lys Ser Gin Arg Ala Glu Thr Ala Glu Thr 210 215 220 Ala Phe Asp Ile Leu Asp Leu Gin Ser Lys Lys Gin Ile Gin Ala Ile 225 230 235 240 Leu Lys Ser Val Val Gly Asn Gin Ala Asn Leu Met Ala Ile Phe Gly 245 250 255 Page 2714 of 3790 Leu Asp Ser Ser Ala Ile Ser Lys Asp Glu Gin Lys Asn Tyr Lys Phe 260 265 270 Ser Phe Asp Asp Ala Asp Ile Asp Glu Lys Ile Ala Asp Ser Glu Ala 275 280 285 Leu Leu Ser Asp Thr Glu Phe Glu Phe Leu Cys Asp Leu Lys Ala Ala 290 295 300 Phe Asp Gly Leu Thr Leu Lys Met Leu Leu Gly Asp Asp Lys Thr Val 305 310 315 320 Ser Ala Ala Met Val Arg Arg Phe Asn Glu His Gin Lys Asp Trp Glu 325 330 335 Tyr Ile Lys Ser His Ile Arg Asn Ala Lys Asn Ala Gly Asn Gly Leu 340 345 350 Tyr Glu Lys Ser Lys Lys Phe Asp Gly Ile Asn Ala Ala Tyr Leu Ala 355 360 365 Leu Gin Ser Asp Asn Glu Asp Asp Arg Lys Lys Ala Lys Lys Ile Phe 370 375 380 Gin Asp Glu Ile Ser Ser Ala Asp Ile Pro Asp Asp Val Lys Ala Asp 385 390 395 400 Phe Leu Lys Lys Ile Asp Asp Asp Gin Phe Leu Pro Ile Gin Arg Thr 405 410 415 Lys Asn Asn Gly Thr Ile Pro His Gin Leu His Arg Asn Glu Leu Glu 420 425 430 Gin Ile Ile Glu Lys Gin Gly Ile Tyr Tyr Pro Phe Leu Lys Asp Thr 435 440 445 Tyr Gin Glu Asn Ser His Glu Leu Asn Lys Ile Thr Ala Leu Ile Asn 450 455 460 Phe Arg Val Pro Tyr Tyr Val Gly Pro Leu Val Glu Glu Glu Gin Lys 465 470 475 480 Ile Ala Asp Asp Gly Lys Asn Ile Pro Asp Pro Thr Asn His Trp Met 485 490 495 Val Arg Lys Ser Asn Asp Thr Ile Thr Pro Trp Asn Leu Ser Gin Val Page 2716 of 3790 Page 2717 of 3790 Page 2718 of 3790 1385 1115 1535 PRT Ornithobacterium rhinotracheale Page 2719 of 3790 Gin Lys Gly Val Arg Lys Leu Tyr Glu Arg Lys Lys Leu Arg Arg Glu 65 70 75 80 Arg Leu His Arg Val Leu Asn Ile Leu Gly Phe Leu Pro Glu His Tyr 85 90 95 Ser Lys Lys Ile Asp Phe Lys Lys His Leu Gly Gin Phe Phe Gly Asn 100 105 110 Ser Gin Pro Lys Ile Ser Tyr Val Glu Asn Asp His Gly Lys His Glu 115 120 125 Phe Ile Phe Met Asp Ser Tyr Arg Glu Met Leu Lys Glu Phe Ser Lys 130 135 140 His Asn Ile Lys Asn Val Pro Tyr Asp Trp Thr Ile Tyr Tyr Leu Arg 145 150 155 160 Lys Lys Ala Leu Ser Gin Lys Ile Ser Lys Glu Glu Leu Ala Trp Val 165 170 175 Ile Leu Asn Phe Asn Lys Lys Arg Gly Tyr Tyr Gin Phe Arg Asp Asp 180 185 190 Asn Ala Asp Glu Asn Lys Glu Asn Lys Ile Glu Lys Tyr Tyr Ala Leu 195 200 205 Lys Val Thr Asn Val Lys Lys Glu Asp Ala Gin Asn Tyr Thr Ile Thr 210 215 220 Leu Glu Asn Gly Trp Ile Tyr Lys Asn Lys Ser Lys Ile Ser Leu Leu 225 230 235 240 Asp Trp Val Gly Ser Thr Lys Glu Phe Ile Ser Thr Glu Lys Phe Asp 245 250 255 Asn Lys Gly Asn Ile Ile Lys Lys Lys Asn Gly Glu Asp Asp Arg Thr 260 265 270 Leu Lys Leu Val Asp Ser Glu Lys Asp Trp Ile Ala Ile Lys Lys Ser 275 280 285 Thr Glu Asp Arg Ile Glu Asn Tyr Gly Lys Thr Val Gly Thr Tyr Leu 290 295 300 Tyr Glu His Leu Leu Lys Asp Pro Asn Gin Lys Leu Asn Gly Glu Leu Page 2721 of 3790 Ser Leu Trp Leu Leu Leu Tyr Ser Ala Lys Asp Glu Arg Glu Leu Lys 565 570 575 Asn Gly Leu Gin Lys Phe Ser Glu Lys Asn Lys Leu Pro Lys Lys Phe 580 585 590 Ser Asp Ile Phe Ile Ser Phe Pro Pro Phe Lys Lys Glu Tyr Gly Ala 595 600 605 Tyr Ser Glu Lys Ala Leu Lys Lys Leu Leu Ser Leu Val Arg Phe Gly 610 615 620 Lys Tyr Trp Ser Phe Asn Lys Ile Asp Asn Asn Ile Gin Asn Lys Ile 625 630 635 640 Met Asn Ile Leu Asn Gly Glu Val Asp Asp Ser Ile Ser Asp Arg Val 645 650 655 Arg Glu Lys Thr Ile Leu Leu Gin Asp Lys Asn Asp Phe Gin Asp Leu 660 665 670 Pro Leu Trp Leu Ala Ser Tyr Val Ala Tyr Asn Arg Phe Ser Glu Val 675 680 685 Ser Glu Ile Lys Tyr Trp Asp Ser Pro Asp Lys Ile Glu Phe Leu Lys 690 695 700 Gin His Ser Ile Gly Asn Pro Ile Val Glu Lys Ile Ile Asn Glu Thr 705 710 715 720 Leu Lys Leu Ile Lys Asp Ile Trp Val Ile His Gly Lys Ser Cys Lys 725 730 735 Asn Phe Phe Ser Glu Ile His Ile Glu Leu Ser Arg Glu Ile Lys Ser 740 745 750 Ser Ser Lys Lys Arg Ala Gin Ile Thr Asn Asn Asn Thr Lys Asn Gin 755 760 765 Lys Leu Asn Asn Leu Ile Lys Ser Leu Leu Ile Glu Met Ala Ser Asp 770 775 780 Thr Lys Tyr Glu Asn Val Thr Pro Tyr Ser Pro Ser Gin Gin Glu Ile 785 790 795 800 Leu Lys Ile Tyr Asp Glu Gly Ile Tyr Ser Lys Glu Glu Asn Ser Glu 805 810 815 Page 2722 of 3790 Page 2723 of 3790 Asn Ile Leu Leu Lys His Leu Asn Ser Thr Lys Tyr Asn Asn Lys Page 2725 of 3790 Ile Lys 1535 1116 103 PRT Parabacteroides merdae 1116 100 1117 82 PRT Parabacteroides merdae 1117 Arg Asp Val Leu Ile Glu Leu Leu Lys Lys Val Gly Phe Met Ser Glu Page 2727 of 3790 Leu Leu Thr Gly Lys Gly Lys Arg Lys Val Phe Ala Ser Asn Gly Gin 85 90 95 Ile Thr Ala Leu Leu Arg Gly Arg Trp Gly Leu Gin Lys Val Arg Asp 100 105 110 Asp Asn Asp Arg His His Ala Leu Asp Ala Val Val Ile Ala Cys Ser 115 120 125 Thr Val Ala Met Gin Gin Lys Ile Thr Arg Phe Val Lys Tyr Glu Glu 130 135 140 Gly Asn Val Phe Ser Gly Glu Arg Ile Asp Arg Glu Thr Gly Glu Ile 145 150 155 160 Ile Pro Leu Tyr Phe Pro Thr Pro Trp Lys Phe Phe Lys Glu Asn Val 165 170 175 Glu Ile Arg Ile Phe Ser Glu Asn Pro Lys Leu Glu Leu Glu Asn Arg 180 185 190 Leu Pro Asp Tyr Pro Gin Tyr Asn His Glu Phe Val Gin Pro Leu Phe 195 200 205 Val Ser Arg Met Pro Thr Arg Lys Met Thr Gly Gin Gly His Met Glu 210 215 220 Thr Ile Lys Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Lys 225 230 235 240 Val Pro Leu Thr Gin Leu Lys Leu Ala Asp Leu Glu Asn Met Val Asn 245 250 255 Arg Glu Arg Glu Leu Ala Leu Tyr Glu Ala Leu Lys Glu Arg Leu Glu 260 265 270 Leu Phe Gly Asn Asp Pro Ala Lys Ala Phe Ile Glu Pro Phe Tyr Lys 275 280 285 Lys Gly Gly Ala Leu Val Lys Ala Val Arg Val Lys Lys Val Gin Lys 290 295 300 Ser Gly Val Leu Val Arg Asp Gly Asn Gly Val Ala Asp Asn Ala Leu 305 310 315 320 Met Val Arg Val Asp Val Phe Thr Lys Gly Gly Lys Tyr Phe Leu Val 385 390 395 1120 610 PRT Pasteurella bettyae 1120 Glu Leu Gly Ala Leu Leu Ser Gly Val Val Thr Asn His Gin Ile Leu Page 2730 of 3790 Lys Val Leu Asn Val Leu Leu Glu Asn Leu Asn Phe Asp Lys Phe Ile 405 410 415 Gin Leu Ser Leu Lys Ala Leu Gin Lys Ile Leu Pro Leu Met Leu Gin 420 425 430 Gly Gin Arg Tyr Asp Glu Ala Val Ser Ala Val Tyr Gly Asp His Tyr 435 440 445 Gly Lys Lys Ser Ala Glu Ser Cys Arg Leu Leu Pro Ala Ile Pro Ala 450 455 460 Asn Glu Ile His Asn Pro Val Val Leu Arg Thr Leu Thr Gin Ala Arg 465 470 475 480 Lys Val Ile Asn Ala Val Val Arg Leu Tyr Gly Ser Pro Ala Arg Ile 485 490 495 His Ile Glu Thr Gly Arg Lys Val Gly Lys Ser Tyr Gin Asp Arg Lys 500 505 510 Lys Leu Glu Lys Gin Gin Glu Glu Asn Arg Glu Gin Arg Glu Ser Ala 515 520 525 Val Lys Lys Phe Lys Glu Tyr Phe Pro Asn Phe Val Gly Glu Pro Lys 530 535 540 Gly Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu Leu Gin Gin Ser Lys 545 550 555 560 Cys Leu Tyr Ser Gly Lys Ser Phe Asp Pro Asn Arg Leu Leu Glu Lys 565 570 575 Gly Tyr Val Glu Val Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp 580 585 590 Asp Ser Phe Asn Asn Lys Val Cys Leu Pro Met Lys Thr Arg Ile Lys 595 600 605 Ala Ile 610 1121 199 PRT Pasteurella multocida 1121 Page 2731 of 3790 Met Ala Cys Ala Thr Pro Ser Met Gin Gin Lys Ile Thr Arg Phe Ile 15 10 15 Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu Met 20 25 30 Val Asp Gin Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu Pro 35 40 45 Trp Ala Tyr Phe Arg Gin Glu Val Asn Ile Arg Val Phe Asp Asn His 50 55 60 Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gin Ala Asn 65 70 75 80 His Gin Phe Val Gin Pro Leu Phe Val Ser Arg Ala Pro Thr Arg Lys 85 90 95 Met Ser Gly Gin Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg Leu 100 105 110 Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gin Leu Lys Pro 115 120 125 Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu Tyr 130 135 140 Ala Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gin Asp Pro Ala Lys 145 150 155 160 Ala Phe Thr Thr Pro Phe Tyr Lys Gin Gly Gly Gin Gin Val Lys Ala 165 170 175 Ile Arg Val Glu Gin Val Gin Lys Ser Gly Val Leu Val Arg Glu Asn 180 185 190 Asn Gly Val Ala Asp Asn Ala 195 1122 63 PRT Pasteurella multocida 1122 Met Gin Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 15 10 15 Page 2732 of 3790 Page 2733 of 3790 Phe Ala Lys Glu Glu Gly His Ile Arg Asn Gin Arg Gly Ala Tyr Thr 180 185 190 His Thr Phe Asn Arg Leu Asp Leu Leu Ala Glu Leu Asn Leu Leu Phe 195 200 205 Ala Gin Gin His Gin Phe Gly Asn Pro His Cys Lys Glu His Ile Gin 210 215 220 Gin Tyr Met Thr Glu Leu Leu Met Trp Gin Lys Pro Ala Leu Ser Gly 225 230 235 240 Glu Ala Ile Leu Lys Met Leu Gly Lys Cys Thr His Glu Lys Asn Glu 245 250 255 Phe Lys Ala Ala Lys His Thr Tyr Ser Ala Glu Arg Phe Val Trp Leu 260 265 270 Thr Lys Leu Asn Asn Leu Arg Ile Leu Glu Asp Gly Ala Glu Arg Ala 275 280 285 Leu Asn Glu Glu Glu Arg Gin Leu Leu Ile Asn His Pro Tyr Glu Lys 290 295 300 Ser Lys Leu Thr Tyr Ala Gin Val Arg Lys Leu Leu Gly Leu Ser Glu 305 310 315 320 Gin Ala Ile Phe Lys His Leu Arg Tyr Ser Lys Glu Ser Ala Glu Ser 325 330 335 Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 340 345 350 Glu Asn Gin Gly Leu Lys Asp Thr Trp Gin Asp Leu Ala Lys Lys Pro 355 360 365 Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 370 375 380 Glu Asp Ile Gin Gin Tyr Leu Glu Gly Lys Leu Pro Asp Ser Val Ile 385 390 395 400 Asn Ala Leu Leu Val Ser Leu Asn Phe Asp Lys Phe Ile Glu Leu Ser 405 410 415 Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gin Gly Lys Arg 420 425 430 Page 2734 of 3790 Tyr Asp Gin Ala Cys His Glu Ile Tyr Gly His His Tyr Gly Glu Lys 435 440 445 Asn Gin Gin Ile Ser Gin Leu Leu Pro Val Ile Pro Thr Gin Glu Ile 450 455 460 Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gin Ala Arg Lys Val Ile 465 470 475 480 Asn Ala Ile Ile Arg Gin Tyr Gly Ser Pro Ala Arg Val His Ile Glu 485 490 495 Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gin 500 505 510 Lys Gin Gin Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gin Lys 515 520 525 Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 530 535 540 Ile Leu Lys Phe Arg Leu Tyr Glu Gin Gin His Gly Lys Cys Leu Tyr 545 550 555 560 Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 565 570 575 Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 580 585 590 Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gin Asn Lys Gly Asn 595 600 605 Gin Thr Pro Tyr Glu Trp Leu Gin Gly Lys Ile Asn Ser Glu Arg Trp 610 615 620 Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gin Cys Ser Ala Ala Lys 625 630 635 640 Lys Gin Arg Leu Leu Thr Gin Val Ile Asp Asp Asn Lys Phe Ile Asp 645 650 655 Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 660 665 670 Ile Gin Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 675 680 685 Page 2735 of 3790 Thr Pro Asn Gly Gin Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 690 695 700 Ile Lys Val Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Ile 705 710 715 720 Val Val Ala Cys Ala Thr Pro Ser Met Gin Gin Lys Ile Thr Arg Phe 725 730 735 Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 740 745 750 Met Val Asp Gin Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 755 760 765 Pro Trp Ala Tyr Phe Arg Gin Glu Val Asn Ile Arg Val Phe Asp Asn 770 775 780 His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gin Ala 785 790 795 800 Asn His Gin Phe Val Gin Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 805 810 815 Lys Met Ser Gly Gin Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 820 825 830 Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gin Leu Lys 835 840 845 Pro Asn Leu Leu Glu Asn Met Val Asn Lys Glu Arg Glu Pro Ala Leu 850 855 860 Tyr Val Gly Leu Lys Ala Arg Leu Ala Glu Phe Asn Gin Asp Pro Ala 865 870 875 880 Lys Ala Phe Ala Thr Pro Phe Tyr Lys Gin Gly Gly Gin Gin Val Lys 885 890 895 Ala Ile Arg Val Glu Leu Val Gin Lys Ser Gly Val Leu Val Arg Gin 900 905 910 Gly Asn Gly Val Ala Asp Asn Ala Pro Gly Ser Ile Val Arg Thr Asp 915 920 925 Val Phe Ile Lys Asn Asn Lys Phe Phe Leu Val Pro Ile Tyr Thr Trp 930 935 Page 2736 of 3790 940 1124 1056 PRT Pasteurella multocida 1124 Met Gin Thr Thr Asn Leu Ser Tyr Ile Leu Gly Leu Asp Leu Gly Ile 15 10 15 Ala Ser Val Gly Trp Ala Val Val Glu Ile Asn Glu Asn Glu Asp Pro 20 25 30 Ile Gly Leu Ile Asp Val Gly Val Arg Ile Phe Glu Arg Ala Glu Val 35 40 45 Pro Lys Thr Gly Glu Ser Leu Ala Leu Ser Arg Arg Leu Ala Arg Ser 50 55 60 Thr Arg Arg Leu Ile Arg Arg Arg Ala Arg Arg Leu Leu Leu Ala Lys 65 70 75 80 Arg Phe Leu Lys Arg Glu Gly Ile Leu Ser Thr Thr Asp Leu Glu Lys Page 2738 of 3790 Ala Thr Phe Met Glu Leu Lys Ala Trp His Ala Ile Arg Lys Ala Leu 340 345 350 Glu Asn Gin Gly Leu Lys Asp Thr Trp Gin Asp Leu Ala Lys Lys Pro 355 360 365 Asp Leu Leu Asp Glu Ile Gly Thr Ala Phe Ser Leu Tyr Lys Thr Asp 370 375 380 Glu Asp Ile Gin Gin Tyr Leu Thr Asn Lys Val Pro Asn Ser Val Ile 385 390 395 400 Asn Ala Leu Leu Val Phe Leu Asn Phe Asp Lys Phe Ile Glu Leu Ala 405 410 415 Leu Lys Ser Leu Arg Lys Ile Leu Pro Leu Met Glu Gin Gly Lys Arg 420 425 430 Tyr Asp Gin Ala Cys Arg Glu Ile Tyr Gly His His Tyr Gly Glu Ala 435 440 445 Asn Gin Lys Thr Ser Gin Leu Leu Pro Ala Ile Pro Ala Gin Glu Ile 450 455 460 Arg Asn Pro Val Val Leu Arg Thr Leu Ser Gin Ala Arg Lys Val Ile 465 470 475 480 Asn Ala Ile Ile Arg Gin Tyr Gly Ser Pro Ala Arg Val His Ile Glu 485 490 495 Thr Gly Arg Glu Leu Gly Lys Ser Phe Lys Glu Arg Arg Glu Ile Gin 500 505 510 Lys Gin Gin Glu Asp Asn Arg Thr Lys Arg Glu Ser Ala Val Gin Lys 515 520 525 Phe Lys Glu Leu Phe Ser Asp Phe Ser Ser Glu Pro Lys Ser Lys Asp 530 535 540 Ile Leu Lys Phe Arg Leu Tyr Glu Gin Gin His Gly Lys Cys Leu Tyr 545 550 555 560 Ser Gly Lys Glu Ile Asn Ile His Arg Leu Asn Glu Lys Gly Tyr Val 565 570 575 Glu Ile Asp His Ala Leu Pro Phe Ser Arg Thr Trp Asp Asp Ser Phe 580 585 590 Page 2739 of 3790 Asn Asn Lys Val Leu Val Leu Ala Ser Glu Asn Gin Asn Lys Gly Asn 595 600 605 Gin Thr Pro Tyr Glu Trp Leu Gin Gly Lys Ile Asn Ser Glu Arg Trp 610 615 620 Lys Asn Phe Val Ala Leu Val Leu Gly Ser Gin Cys Ser Ala Ala Lys 625 630 635 640 Lys Gin Arg Leu Leu Thr Gin Val Ile Asp Asp Asn Lys Phe Ile Asp 645 650 655 Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Arg Phe Leu Ser Asn Tyr 660 665 670 Ile Gin Glu Asn Leu Leu Leu Val Gly Lys Asn Lys Lys Asn Val Phe 675 680 685 Thr Pro Asn Gly Gin Ile Thr Ala Leu Leu Arg Ser Arg Trp Gly Leu 690 695 700 Ile Lys Ile Arg Glu Asn Asn Asp Arg His His Ala Leu Asp Ala Ile 705 710 715 720 Val Val Ala Cys Ala Thr Pro Ser Met Gin Gin Lys Ile Thr Arg Phe 725 730 735 Ile Arg Phe Lys Glu Val His Pro Tyr Lys Ile Glu Asn Arg Tyr Glu 740 745 750 Met Val Asp Gin Glu Ser Gly Glu Ile Ile Ser Pro His Phe Pro Glu 755 760 765 Pro Trp Ala Tyr Phe Arg Gin Glu Val Asn Ile Arg Val Phe Asp Asn 770 775 780 His Pro Asp Thr Val Leu Lys Glu Met Leu Pro Asp Arg Pro Gin Ala 785 790 795 800 Asn His Gin Phe Val Gin Pro Leu Phe Val Ser Arg Ala Pro Thr Arg 805 810 815 Lys Met Ser Gly Gin Gly His Met Glu Thr Ile Lys Ser Ala Lys Arg 820 825 830 Leu Ala Glu Gly Ile Ser Val Leu Arg Ile Pro Leu Thr Gin Leu Lys 835 840 845 Page 2740 of 3790 Gly Tyr Tyr Ile Gly Leu Asp Arg Ala Thr Gly Asn Ile Ser Leu Lys 995 1000 1005 Pro Val Arg 1055 1125 134 PRT Pasteurella multocida Page 2741 of 3790 1125 Met Val Asn Lys Glu Arg Glu Pro Ala Leu Tyr Ala Gly Leu Lys Ala 15 10 15 Arg Leu Ala Glu Phe Asn Gin Asp Pro Ala Lys Ala Phe Thr Thr Pro 20 25 30 Phe Tyr Lys Gin Gly Gly Gin Gin Val Lys Ala Ile Arg Val Glu Gin 35 40 45 Val Gin Lys Ser Gly Val Leu Val Arg Glu Asn Asn Gly Val Ala Asp 50 55 60 Asn Ala Ser Ile Val Arg Thr Asp Val Phe Ile Lys Asn Asn Lys Phe 65 70 75 80 Phe Leu Val Pro Ile Tyr Thr Trp Gin Val Ala Lys Gly Ile Leu Pro 85 90 95 Asn Lys Ala Ile Val Ala His Lys Asn Glu Asp Glu Trp Glu Glu Met 100 105 110 Asp Glu Gly Ala Lys Phe Lys Phe Ser Leu Phe Pro Asn Asp Leu Val 115 120 125 Glu Leu Lys Thr Lys Lys 130 1126 53 PRT Pasteurella multocida 1126 Tyr Ser Lys Glu Asn Ala Glu Ser Ala Thr Phe Met Glu Leu Lys Ala 15 10 15 Trp His Ala Ile Arg Lys Ala Leu Glu Asn Gin Gly Leu Lys Asp Thr 20 25 30 Trp Gin Asp 35 Leu Ala Lys Lys Pro Asp Leu Leu Asp 40 Glu Ile Gly Thr Ala Phe Ser 50 Leu Leu 1127 1366 Page 2742 of 3790 PRT Pediococcus acidilactici 1127 Met Gly Asp Arg Lys Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser Ser 15 10 15 Ile Gly Phe Ala Ala Val Asp Glu Asn Asn Gin Pro Ile Arg Val Lys 20 25 30 Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala 35 40 45 Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 50 55 60 Arg Trp Arg Ile Asn Leu Leu Asn Glu Ile Phe Asp Ala His Leu Ala 65 70 75 80 Glu Val Asp Pro Thr Phe Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser 85 90 95 Asn Leu Asp Pro Lys Lys Ser Phe Gin Gly Ser Leu Leu Phe Pro Glu 100 105 110 Arg Lys Asp Tyr Gin Phe Tyr Glu Glu Tyr Pro Thr Ile Tyr His Leu 115 120 125 Arg Lys Ala Leu Met Glu Glu Asp Arg Lys Phe Asp Ile Arg Glu Ile 130 135 140 Tyr Leu Ala Val His His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Asn 145 150 155 160 Gly Thr Pro Met Arg Ser Phe Lys Val Glu Asn Ile Glu Leu Asp Thr 165 170 175 Leu Phe Asp Gin Leu Asn Gin Leu Tyr Ala Glu Ile Val Pro Asp Asn 180 185 190 Glu Leu Ala Phe Asp Leu Ala Gin Val Ala Asp Val Lys Asp Val Leu 195 200 205 Ser Ser Thr Thr Ile Tyr Lys Met Asp Lys Lys Lys Gin Leu Val Lys 210 215 220 Met Met Leu Leu Pro Ala Ser Asn Lys Ala Leu Gin Ser Glu Asn Lys 225 230 235 240 Page 2743 of 3790 Lys Ile Val Thr Gin Phe Val Asn Ala Ile Leu Asn Tyr Lys Phe Lys 245 250 255 Leu Asp Val Leu Leu Gin Val Glu Thr Asp Ala Asp Trp Ser Leu Lys 260 265 270 Leu Asn Asp Glu Gly Ala Asp Asp Lys Leu Glu Glu Phe Thr Gly Asp 275 280 285 Leu Asp Glu Asn Arg Leu Glu Ile Ile Asp Leu Leu Gin Arg Leu His 290 295 300 Asn Trp Phe Ser Leu Asn Glu Ile Thr Lys Asp Gly Asn Ser Leu Ser 305 310 315 320 Ala Ala Met Val Glu Lys Tyr Glu Asn His His His His Leu Gly Leu 325 330 335 Leu Lys Lys Val Ile Glu Asn His Pro Asp Ala Lys Lys Ala Lys Ala 340 345 350 Leu Lys Glu Thr Tyr Thr Ala Tyr Val Gly Lys Thr Asp Asp Lys Thr 355 360 365 Gin Asn Gin Asp Asp Phe Tyr Lys Ala Val Glu Lys Asn Leu Asp Asp 370 375 380 Ser Pro Asp Ala Lys Glu Ile Lys Arg Leu Ile Gin Leu Asp Gin Phe 385 390 395 400 Met Pro Lys Gin Arg Thr Gly Gin Asn Gly Ala Ile Pro His Gin Leu 405 410 415 His Gin Gin Glu Leu Asp Gin Ile Ile Glu Lys Gin Ser Lys Tyr Tyr 420 425 430 Pro Phe Leu Ala Glu Pro Asn Pro Asn Val Lys Arg Arg Lys Asp Ala 435 440 445 Pro Tyr Lys Leu Asp Glu Leu Ile Ala Phe Lys Ile Pro Tyr Tyr Val 450 455 460 Gly Pro Leu Val Thr Pro Glu Glu Gin Ala Gin Asn Lys Glu Asn Val 465 470 475 480 Phe Ala Trp Met Lys Arg Lys Ala Ala Gly Pro Ile Thr Pro Trp Asn Page 2745 of 3790 Ile Leu Gly Asp Ala Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg 740 745 750 Gin Val Val Lys Val Val Gin Asp Ile Glu Lys Ala Val Gly Asn Pro 755 760 765 Pro Glu Lys Ile Ala Ile Glu Phe Thr Arg Glu Ala Ala Ala Asn Pro 770 775 780 Gin Arg Thr Gin Ser Arg Leu Arg Thr Leu Glu Lys Leu Tyr Glu Ser 785 790 795 800 Ala Glu Glu Val Val Asp Ala Gly Leu Thr Ala Glu Leu Ala Glu Phe 805 810 815 Lys Glu Asn Lys His Val Leu Ser Asp Lys Tyr Tyr Leu Tyr Phe Thr 820 825 830 Gin Leu Gly Arg Asp Val Tyr Thr Gly Asp Thr Ile Ser Leu Asp Lys 835 840 845 Leu Asn Asp Tyr Asp Val Asp His Ile Leu Pro Gin Ser Phe Ile Lys 850 855 860 Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ile Arg Ala Val Asn Asn 865 870 875 880 Gly Lys Ser Asp Asn Val Pro Ala Lys Met Phe Gly Lys Lys Met Gly 885 890 895 Ser Phe Trp Arg Tyr Leu Leu Asp Asn Gly Met Ile Ser Lys Arg Lys 900 905 910 Tyr Asn Asn Leu Ile Thr Asp Pro Asp Asn Ile Ser Lys Tyr Ala Gin 915 920 925 Lys Gly Phe Ile Asn Arg Gin Leu Val Glu Thr Ser Gin Val Ile Lys 930 935 940 Leu Thr Ala Asn Ile Leu Asn Gly Ile Tyr Asp Lys Asp Thr Glu Ile 945 950 955 960 Ile Glu Val Pro Ala Lys Met Asn Ser Gin Met Arg Lys Met Phe Asp 965 970 975 Leu Val Lys Val Arg Glu Val Asn Asp Tyr His His Ala Phe Asp Ala 980 985 990 Page 2746 of 3790 Tyr Leu Thr Ile Phe Ile Gly Lys Tyr Leu Tyr Lys Cys Tyr Pro Lys 995 1000 1005 Page 2747 of 3790 1128 1229 PRT Pediococcus acidilactici 1128 Met Gly Asp Arg Lys Tyr Asn Leu Gly Leu Asp Ile Gly Thr Ser Ser 15 10 15 Ile Gly Phe Ala Ala Val Asp Glu Asn Asn Gin Pro Ile Arg Val Lys 20 25 30 Gly Lys Thr Ala Ile Gly Val Arg Leu Phe Glu Glu Gly Lys Thr Ala 35 40 45 Ala Asp Arg Arg Gly Phe Arg Thr Thr Arg Arg Arg Leu Ser Arg Arg 50 55 60 Arg Trp Arg Ile Asn Leu Leu Asn Glu Ile Phe Asp Ala His Leu Ala 65 70 75 80 Page 2748 of 3790 Glu Val Asp Pro Thr Phe Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser 85 90 95 Asn Leu Asp Pro Lys Lys Ser Phe Gin Gly Ser Leu Leu Phe Pro Glu 100 105 110 Arg Lys Asp Tyr Gin Phe Tyr Glu Glu Tyr Pro Thr Ile Tyr His Leu 115 120 125 Arg Lys Ala Leu Met Glu Lys Asp Arg Lys Phe Asp Ile Arg Glu Ile 130 135 140 Tyr Leu Ala Val His His Ile Ile Lys Tyr Arg Gly Asn Phe Leu Asn 145 150 155 160 Gly Thr Pro Met Arg Ser Phe Lys Val Glu Asn Ile Glu Leu Asn Thr 165 170 175 Leu Phe Asp Gin Leu Asn Gin Leu Tyr Ala Glu Ile Val Pro Asp Asn 180 185 190 Glu Leu Ala Phe Asp Leu Ala Gin Val Ala Asp Val Lys Asp Val Leu 195 200 205 Ser Ser Thr Thr Ile Tyr Lys Met Asp Lys Lys Lys Gin Leu Val Lys 210 215 220 Met Met Leu Leu Pro Ala Ser Asn Lys Ala Leu Gin Ser Glu Asn Lys 225 230 235 240 Lys Ile Val Thr Gin Phe Val Asn Ala Ile Leu Asn Tyr Lys Phe Lys 245 250 255 Leu Asp Val Leu Leu Gin Val Glu Thr Asp Ala Asp Trp Ser Leu Lys 260 265 270 Leu Asn Asp Glu Gly Ala Asp Asp Lys Leu Glu Glu Phe Thr Gly Asp 275 280 285 Leu Asp Glu Asn Arg Leu Glu Ile Ile Asp Leu Leu Gin Arg Leu His 290 295 300 Asn Trp Phe Ser Leu Asn Glu Ile Thr Lys Asp Gly Asn Ser Leu Ser 305 310 315 320 Ala Ala Met Val Glu Lys Tyr Glu Asn His His His His Leu Gly Leu Page 2750 of 3790 Leu Gin Asn Tyr Tyr Val Thr Lys Lys Lys Ala Ala Thr Ala Pro Thr 580 585 590 Val Gly Gly Leu Ala Asp Pro Lys Lys Phe Leu Ser Ser Leu Ser Thr 595 600 605 Tyr Ile Asp Phe Lys Asn Met Phe Gly Glu Arg Val Asn Asp Pro Gin 610 615 620 Phe Gin Glu Asp Leu Glu Gin Ile Val Glu Trp Ser Thr Ile Phe Glu 625 630 635 640 Asp Arg Gly Ile Phe Lys Ala Lys Leu Gin Ala Leu Gly Trp Leu Ser 645 650 655 Glu Lys Gin Ile Gin Gin Leu Val Ala Lys Arg Tyr Lys Gly Trp Gly 660 665 670 Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Lys Asn Ala Glu Gly Tyr 675 680 685 Ser Ile Leu Asp Glu Met Trp Arg Ser Thr Glu Asn Phe Met Gin Ile 690 695 700 Gin Ser Arg Pro Glu Phe Ala Ala Leu Ile Gin Gin Ala Asn Glu Lys 705 710 715 720 Gin Phe Glu Gly Asn Asp Pro Asp Asn Val Trp Glu Asn Ile Glu Asn 725 730 735 Ile Leu Gly Asp Ala Tyr Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg 740 745 750 Gin Val Val Lys Val Val Gin Asp Ile Glu Lys Ala Val Gly Asn Pro 755 760 765 Pro Glu Lys Ile Ala Ile Glu Phe Thr Arg Glu Ala Ala Ala Asn Pro 770 775 780 Gin Arg Thr Gin Ser Arg Leu Arg Thr Leu Glu Lys Leu Tyr Glu Ser 785 790 795 800 Ala Glu Glu Val Val Asp Ala Gly Leu Thr Ala Glu Leu Ala Glu Phe 805 810 815 Lys Glu Asn Lys His Val Leu Ser Asp Lys Tyr Tyr Leu Tyr Phe Thr 820 825 830 Page 2751 of 3790 Page 2752 of 3790 Ala Lys Gin Leu Val Leu Ser Glu Lys Ala Leu 1220 1225 1129 270 PRT Pediococcus lolii 1129 Leu Phe Asn Gin Thr Ile Tyr Ser Ala Lys Ala Ser Lys Thr Met Ile 15 10 15 Pro Ile Lys Asn Asp Arg Pro 20 Thr Lys 25 Leu Tyr Gly Gly Tyr 30 Ser Gly Asn Glu Asp Ala 35 Tyr Met Ser Ile 40 Ile Arg Leu Ser Asp Lys 45 Lys Lys Thr Tyr Lys Val Val Gly Ile Ser Met Arg Asp Ala Ser Lys Leu Lys 50 55 60 Page 2753 of 3790 1130 1016 PRT Pediococcus lolii 1130 Met Asn Gly Ile Phe Asp Ala His Leu Ala Glu Val Asp Pro Thr Phe 15 10 15 Page 2754 of 3790 Leu Ala Arg Leu Lys Glu Ser Asn Arg Ser Asn Leu Asp Pro Lys Lys 20 25 30 Ser Phe Gin Gly Ser Leu Leu Phe Pro Glu Arg Lys Asp Tyr Gin Phe 35 40 45 Tyr Lys Glu Tyr Pro Thr Ile Tyr His Leu Arg Lys Ala Leu Met Glu 50 55 60 Lys Asp Arg Lys Phe Asp Ile Arg Glu Ile Tyr Leu Ala Val His His 65 70 75 80 Ile Ile Lys Tyr Arg Gly Asn Phe Leu Asn Gly Thr Pro Met Arg Ser 85 90 95 Phe Lys Val Glu Asn Ile Glu Leu Asp Thr Leu Phe Asp Arg Leu Asn 100 105 110 Gin Leu Tyr Glu Glu Ile Ile Pro Asp Asn Glu Leu Ala Phe Asp Leu 115 120 125 Glu Gin Val Ala Asp Val Lys Glu Val Leu Ser Ser Thr Thr Ile Tyr 130 135 140 Lys Met Asp Lys Lys Lys Gin Leu Val Lys Met Met Leu Leu Pro Ala 145 150 155 160 Ser Asn Lys Ala Leu Gin Ser Glu Asn Lys Lys Ile Val Thr Gin Phe 165 170 175 Val Asn Ala Ile Leu Asn Tyr Lys Phe Lys Leu Asp Val Leu Leu Gin 180 185 190 Val Glu Thr Asp Ala Asp Trp Ser Leu Lys Leu Asn Asp Glu Gly Ala 195 200 205 Asp Asp Lys Leu Glu Glu Phe Thr Gly Asp Leu Asp Glu Asn Arg Leu 210 215 220 Glu Ile Ile Asp Leu Leu Gin Arg Leu His Asn Trp Phe Ser Leu Asn 225 230 235 240 Glu Ile Thr Lys Asp Gly Asn Ser Leu Ser Ala Ala Met Val Glu Lys 245 250 255 Tyr Lys Asp His Arg His His Leu Glu Leu Leu Lys Lys Val Ile Glu Page 2756 of 3790 Thr Lys Lys Lys Ala Ala Thr Ala Pro Thr Val Gly Gly Leu Ala Asp 515 520 525 Pro Lys Lys Phe Leu Ser Ser Leu Ser Thr Tyr Ile Asp Phe Lys Asn 530 535 540 Met Phe Gly Glu Arg Val Asn Asp Pro Gin Phe Gin Glu Asp Leu Glu 545 550 555 560 Gin Ile Val Glu Trp Ser Thr Ile Phe Glu Asp Arg Gly Ile Phe Lys 565 570 575 Ala Lys Leu Gin Ala Leu Gly Trp Leu Ser Glu Lys Gin Ile Gin Gin 580 585 590 Leu Val Ala Lys Arg Tyr Lys Gly Trp Gly Arg Leu Ser Lys Lys Leu 595 600 605 Leu Thr Gly Leu Lys Asn Ala Glu Gly Tyr Ser Ile Leu Asp Glu Met 610 615 620 Trp His Ser Thr Glu Asn Phe Met Gin Ile Gin Thr Arg Pro Glu Phe 625 630 635 640 Ala Ala Leu Ile Gin Gin Ala Asn Glu Lys Gin Phe Glu Gly Asn Asp 645 650 655 Pro Asp Asn Val Trp Glu Asn Ile Glu Asn Ile Leu Gly Asp Ala Tyr 660 665 670 Thr Ser Pro Gin Asn Lys Lys Ala Ile Arg Gin Val Val Lys Val Val 675 680 685 Gin Asp Ile Glu Lys Ala Val Gly Asn Pro Pro Glu Lys Ile Ala Ile 690 695 700 Glu Phe Thr Arg Glu Ala Ala Ala Asn Pro Gin Arg Thr Gin Ser Arg 705 710 715 720 Leu Arg Thr Leu Glu Lys Leu Tyr Glu Ser Ala Glu Glu Val Val Asp 725 730 735 Ala Gly Leu Thr Ala Glu Leu Ala Glu Phe Lys Glu Asn Lys His Val 740 745 750 Leu Ser Asp Lys Tyr Tyr Leu Tyr Phe Thr Gin Leu Gly Arg Asp Val 755 760 765 Page 2757 of 3790 Page 2758 of 3790 1131 1333 PRT Planococcus antarcticus 1131 Met Lys Asn Tyr Thr Ile Gly Leu Asp Ile Gly Val Ala Ser Val Gly 15 10 15 Trp Val Cys Ile Asp Glu Asn Tyr Lys Ile Leu Asn Tyr Asn Asn Arg 20 25 30 His Ala Phe Gly Val His Glu Phe Glu Ser Ala Glu Ser Ala Ala Gly 35 40 45 Arg Arg Leu Lys Arg Gly Met Arg Arg Arg Tyr Asn Arg Arg Lys Lys 50 55 60 Arg Leu Gin Leu Leu Gin Ser Leu Phe Asp Ser Tyr Ile Thr Asp Ser 65 70 75 80 Gly Phe Phe Ser Lys Thr Asp Ser Gin His Phe Trp Lys Asn Asn Asn 85 90 95 Glu Phe Glu Asn Arg Ser Leu Thr Glu Val Leu Ser Ser Leu Arg Ile 100 105 110 Ser Ser Arg Lys Tyr Pro Thr Ile Tyr His Leu Arg Ser Asp Leu Ile 115 120 125 Glu Ser Asn Lys Lys Met Asp Leu Arg Leu Val Tyr Leu Ala Leu His 130 135 140 Asn Leu Val Lys Tyr Arg Gly His Phe Leu Gin Glu Gly Asn Trp Ser 145 150 155 160 Glu Ala Ala Ser Ala Glu Gly Met Asp Asp Gin Leu Leu Glu Leu Val 165 170 175 Thr Arg Tyr Ala Glu Leu Glu Asn Leu Ser Pro Leu Asp Leu Ser Glu 180 185 190 Ser Gin Trp Lys Ala Ala Glu Thr Leu Leu Leu Asn Arg Asn Leu Thr 195 200 205 Lys Thr Asp Gin Ser Lys Glu Leu Thr Ala Met Phe Gly Lys Glu Tyr 210 215 220 Page 2759 of 3790 Glu Pro Phe Cys Lys Leu Val Ala Gly Leu Gly Val Ser Leu His Gin 225 230 235 240 Leu Phe Pro Ser Ser Glu Gin Ala Leu Ala Tyr Lys Glu Thr Lys Thr 245 250 255 Lys Val Gin Leu Ser Asn Glu Asn Val Glu Glu Val Met Glu Leu Leu 260 265 270 Leu Glu Glu Glu Ser Ala Leu Leu Glu Ala Val Gin Pro Phe Tyr Gin 275 280 285 Gin Val Val Leu Tyr Glu Leu Leu Lys Gly Glu Thr Tyr Val Ala Lys 290 295 300 Ala Lys Val Ser Ala Phe Lys Gin Tyr Gin Lys Asp Met Ala Ser Leu 305 310 315 320 Lys Asn Leu Leu Asp Lys Thr Phe Gly Glu Lys Val Tyr Arg Ser Tyr 325 330 335 Phe Ile Ser Asp Lys Asn Ser Gin Arg Glu Tyr Gin Lys Ser His Lys 340 345 350 Val Glu Val Leu Cys Lys Leu Asp Gin Phe Asn Lys Glu Ala Lys Phe 355 360 365 Ala Glu Thr Phe Tyr Lys Asp Leu Lys Lys Leu Leu Glu Asp Lys Ser 370 375 380 Lys Thr Ser Ile Gly Thr Thr Glu Lys Asp Glu Met Leu Arg Ile Ile 385 390 395 400 Lys Ala Ile Asp Ser Asn Gin Phe Leu Gin Lys Gin Lys Gly Ile Gin 405 410 415 Asn Ala Ala Ile Pro His Gin Asn Ser Leu Tyr Glu Ala Glu Lys Ile 420 425 430 Leu Arg Asn Gin Gin Ala His Tyr Pro Phe Ile Thr Thr Glu Trp Ile 435 440 445 Glu Lys Val Lys Gin Ile Leu Ala Phe Arg Ile Pro Tyr Tyr Ile Gly 450 455 460 Pro Leu Val Lys Asp Thr Thr Gin Ser Pro Phe Ser Trp Val Glu Arg Page 2761 of 3790 Gly Leu Glu Lys Lys Ile Gin Lys Met Asn Gin His Gin Val Asp Gly 725 730 735 Thr Lys Lys Ile Arg Tyr Glu Asp Ile Glu Glu Leu Ala Gly Ser Pro 740 745 750 Ala Leu Lys Arg Gly Ile Trp Arg Ser Val Lys Ile Val Glu Glu Leu 755 760 765 Val Ser Ile Phe Gly Glu Pro Ala Asn Ile Val Leu Glu Val Ala Arg 770 775 780 Glu Asp Gly Glu Lys Lys Arg Thr Lys Ser Arg Lys Asp Gin Trp Glu 785 790 795 800 Glu Leu Thr Lys Thr Thr Leu Lys Asn Asp Pro Asp Leu Lys Ser Phe 805 810 815 Ile Gly Glu Ile Lys Ser Gin Gly Asp Gin Arg Phe Asn Glu Gin Arg 820 825 830 Phe Trp Leu Tyr Val Thr Gin Gin Gly Lys Cys Leu Tyr Thr Gly Lys 835 840 845 Ala Leu Asp Ile Gin Asn Leu Ser Met Tyr Glu Val Asp His Ile Leu 850 855 860 Pro Gin Asn Phe Val Lys Asp Asp Ser Leu Asp Asn Leu Ala Leu Val 865 870 875 880 Met Pro Glu Ala Asn Gin Arg Lys Asn Gin Val Gly Gin Asn Lys Met 885 890 895 Pro Leu Glu Ile Ile Glu Ala Asn Gin Gin Tyr Ala Met Arg Thr Leu 900 905 910 Trp Glu Arg Leu His Glu Leu Lys Leu Ile Ser Ser Gly Lys Leu Gly 915 920 925 Arg Leu Lys Lys Pro Ser Phe Asp Glu Val Asp Lys Asp Lys Phe Ile 930 935 940 Ala Arg Gin Leu Val Glu Thr Arg Gin Ile Ile Lys His Val Arg Asp 945 950 955 960 Leu Leu Asp Glu Arg Phe Ser Lys Ser Asp Ile His Leu Val Lys Ala 965 970 975 Page 2762 of 3790 Gly Ile Val Ser Lys Phe Arg Arg Phe Ser Glu Ile Pro Lys Ile Arg 980 985 990 Asp Tyr Asn Asn Lys His His Ala Met Asp Ala Leu Phe Ala Ala Ala 995 1000 1005 Page 2763 of 3790 10 15 Trp Cys Leu Ile Thr Leu Asp Lys Asp Glu Lys Pro Gin Ser Ile Leu 20 25 30 Gly Met Gly Ser Arg Ile Val Pro Leu Ser Ala Asp Asp Ala Thr Glu 35 40 45 Phe Thr Gin Gly Lys Ala Ile Thr Lys Asn Lys Met Arg Thr Val Ala 50 55 60 Arg Thr Ile Arg Lys Gly Met Asp Arg Tyr Gin Leu Arg Arg Glu Ala 65 70 75 80 Leu Lys Lys Val Leu Arg Glu His Ala Met Leu Pro Asp Glu Ala Leu 85 90 95 Page 2764 of 3790 Page 2765 of 3790 Phe Gin Val Cys Lys Val Trp Glu Ser Ile His Asn Ile Arg Leu Tyr 100 105 110 His Pro Asp Gly Thr Glu Arg Lys Leu Glu Gin Glu Glu Lys Gin Lys 115 120 125 Leu Phe Asp Tyr Leu Gin Arg Asn Asp Lys Leu Ser Leu Thr Thr Leu 130 135 140 Arg Lys Glu Leu Lys Ile Lys Pro Lys Asp Lys Leu Trp Cys Asp Lys 145 150 155 160 Leu Leu Glu Lys Gly Ile Ala Gly Asn Thr Thr Ala Ala Ile Leu Arg 165 170 175 Lys Ala Phe Lys Gly Tyr Glu His Tyr Glu Arg Leu Phe Arg Phe Asp 180 185 190 Leu Val Arg Arg Asp Ser His Glu Ala Asp Glu Asp Gly Val Ile Arg 195 200 205 Pro Ile Ile Asp Glu Ser Tyr Gin Asn Glu Pro Leu Tyr Lys Leu Trp 210 215 220 His Ile Leu Tyr Ser Ile Glu Asp Arg Ala Glu Met Arg Ser Ala Leu 225 230 235 240 Ile Gly Gin Leu Gly Ile Lys Ala Glu Asp Leu Asp Asn Gly Leu Met 245 250 255 Asp Ala Leu Tyr Lys Ile Asp Phe Val Lys Gin Gly Tyr Gly Asn Lys 260 265 270 Ser Ala Lys Phe Ile Cys Lys Leu Leu Pro His Leu Gin Glu Gly Lys 275 280 285 Met Tyr Ser Glu Ala Ala Glu Ala Ala Gly Met Arg His Ser Asp Ser 290 295 300 Met Thr Ala Gin Glu Arg Asp Glu Arg Asn Leu Leu Glu Glu Ile Pro 305 310 315 320 Leu Leu Gin Lys Asn Ala Leu Arg Gin Pro Val Val Glu Lys Val Leu 325 330 335 Asn Gin Met Ile Asn Leu Val Asn Ala Leu Lys Arg Glu His Gly Glu Page 2767 of 3790 Ile Lys Asp Trp Ser Lys Arg Lys Asp His Arg His His Ala Ile Asp 595 600 605 Ala Leu Val Val Ala Cys Thr Arg Gin Ser Tyr Ile Gin Arg Leu Asn 610 615 620 Arg Val Asn Ala Glu Ala Asp Arg Gin Glu Met Asp Ala Phe Ile Lys 625 630 635 640 Glu Gin Gin Gin Glu His Lys Leu Ser Lys Lys Glu Lys Leu Ser Leu 645 650 655 Leu Glu Asn Trp Leu Lys Glu Gin Pro His Phe Thr Thr Gly Glu Val 660 665 670 Lys Glu His Ala Glu Gly Ile Leu Ile Ser Phe Arg Pro Gly Lys Arg 675 680 685 Thr Val Ser Arg Gly Arg Asn Ile Tyr Lys Arg Ser Gly Lys Thr Asp 690 695 700 Val Gin Arg Asn Val Leu Ile Pro Arg Gly Ala Leu Ser Glu Glu Thr 705 710 715 720 Val Tyr Gly Val Ile Ser Val Asp Gly Glu Asn Lys Val Val Cys Lys 725 730 735 Tyr Pro Leu Gin Lys Phe Leu Asp Thr Lys Glu Thr Asn Val Asp Lys 740 745 750 Ile Ala Asp Gin Ala Ala Glu Lys Ile Val Asp Lys Val Leu Arg Glu 755 760 765 Lys Ile Arg Glu Arg Ile Lys Arg Tyr Gly Lys Lys Glu Ala Phe Ala 770 775 780 Glu Pro Leu Tyr Leu Asp Glu Ala Gin Thr Gin Val Val Arg Ser Val 785 790 795 800 Arg Cys Phe Ile Ser Lys Asp Gin Ala Lys Leu Ile Pro Leu Arg Tyr 805 810 815 Asn Asp Glu Ser Glu Ala Val Gly Phe Val Ala Pro Gly Asn Asn His 820 825 830 His Leu Ala Leu Tyr Arg Asp Ala Ser Gly Lys Met Arg Ala Ser Val 835 840 845 Page 2768 of 3790 Page 2769 of 3790 Ala Ile Glu Ala Phe Asn Ala Gly Ala Ala Phe Thr Ala Ser Gin Glu 50 55 60 Arg Thr Ala Arg Arg Thr Met Arg Arg Gly Phe Ala Arg Tyr Gin Leu 65 70 75 80 Arg Arg Tyr Arg Leu Arg Arg Glu Leu Glu Lys Val Gly Met Leu Pro 85 90 95 Asp Ala Ala Leu Ile Gin Leu Pro Leu Leu Glu Leu Trp Glu Leu Arg 100 105 110 Glu Arg Ala Ala Thr Ala Gly Arg Arg Leu Thr Leu Pro Glu Leu Gly 115 120 125 Arg Val Leu Cys His Ile Asn Gin Lys Arg Gly Tyr Arg His Val Lys 130 135 140 Ser Asp Ala Ala Ala Ile Val Gly Asp Glu Gly Glu Lys Lys Lys Asp 145 150 155 160 Ser Asn Ser Ala Tyr Leu Ala Gly Ile Arg Ala Asn Asp Glu Lys Leu 165 170 175 Gin Ala Glu His Lys Thr Val Gly Gin Tyr Phe Ala Glu Gin Leu Arg 180 185 190 Gin Asn Gin Ser Glu Ser Pro Thr Gly Gly Ile Ser Tyr Arg Ile Lys 195 200 205 Asp Gin Ile Phe Ser Arg Gin Cys Tyr Ile Asp Glu Tyr Asp Gin Ile 210 215 220 Met Ala Val Gin Arg Val His Tyr Pro Asp Ile Leu Thr Asp Glu Phe 225 230 235 240 Ile Arg Met Leu Arg Asp Glu Val Ile Phe Met Gin Arg Pro Leu Lys 245 250 255 Ser Cys Lys His Leu Val Ser Leu Cys Glu Phe Glu Lys Gin Glu Arg 260 265 270 Val Met Arg Val Gin Gin Asp Asp Gly Lys Gly Gly Trp Gin Leu Val 275 280 285 Glu Arg Arg Val Lys Phe Gly Pro Lys Val Ala Pro Lys Ser Ser Pro 290 295 300 Page 2770 of 3790 Leu Phe Gin Leu Cys Cys Ile Tyr Glu Ala Val Asn Asn Ile Arg Leu 305 310 315 320 Thr Arg Pro Asn Gly Ser Pro Cys Asp Ile Thr Pro Glu Glu Arg Ala 325 330 335 Lys Ile Val Ala His Leu Gin Ser Ser Ala Ser Leu Ser Phe Ala Ala 340 345 350 Leu Lys Lys Leu Leu Lys Glu Lys Ala Leu Ile Ala Asp Gin Leu Thr 355 360 365 Ser Lys Ser Gly Leu Lys Gly Asn Ser Thr Arg Val Ala Leu Ala Ser 370 375 380 Ala Leu Gin Pro Tyr Pro Gin Tyr His His Leu Leu Asp Met Glu Leu 385 390 395 400 Glu Thr Arg Met Met Thr Val Gin Leu Thr Asp Glu Glu Thr Gly Glu 405 410 415 Val Thr Glu Arg Glu Val Ala Val Val Thr Asp Ser Tyr Val Arg Lys 420 425 430 Pro Leu Tyr Arg Leu Trp His Ile Leu Tyr Ser Ile Glu Glu Arg Glu 435 440 445 Ala Met Arg Arg Ala Leu Ile Thr Gin Leu Gly Met Lys Glu Glu Asp 450 455 460 Leu Asp Gly Gly Leu Leu Asp Gin Leu Tyr Arg Leu Asp Phe Val Lys 465 470 475 480 Pro Gly Tyr Gly Asn Lys Ser Ala Lys Phe Ile Cys Lys Leu Leu Pro 485 490 495 Gin Leu Gin Gin Gly Leu Gly Tyr Ser Glu Ala Cys Ala Ala Val Gly 500 505 510 Tyr Arg His Ser Asn Ser Pro Thr Ser Glu Glu Ile Thr Glu Arg Thr 515 520 525 Leu Leu Glu Lys Ile Pro Leu Leu Gin Arg Asn Glu Leu Arg Gin Pro 530 535 540 Leu Val Glu Lys Ile Leu Asn Gin Met Ile Asn Leu Val Asn Ala Leu Page 2772 of 3790 Page 2773 of 3790 1135 1422 PRT Prevotella denticola 1135 Met Thr Gin Lys Val Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly 15 10 15 Ser Ser Val Arg Asn 20 Leu Asp Leu Ser Asp Asp Leu Lys 25 Gly Gin Leu 30 Glu Phe Phe 35 Ser Ser Asp Ile Phe Arg Ser 40 Ser Val Asn 45 Lys Glu Ser Asn Gly Arg Glu Tyr Ser Leu Ala Ala Gin Arg Ser Ala His Ser Arg 50 55 60 Page 2774 of 3790 Ser Arg Gly Leu Asn Glu Ala Arg Arg Arg Lys Leu Trp Ala Thr Leu 65 70 75 80 Asp Leu Leu Ile Lys Tyr Gly Phe Cys Pro Met Ser Pro Glu Ser Leu 85 90 95 Met Arg Trp Arg Thr Tyr Asp Lys Gin Arg Gly Leu Phe Arg Glu Tyr 100 105 110 Pro Ile Asp Asp Lys Asn Phe Asn Ala Trp Ile Leu Leu Asp Phe Asp 115 120 125 Gly Asp Gly Lys Pro Asp Tyr Ser Ser Pro Tyr Gin Leu Arg Arg Glu 130 135 140 Leu Val Ile Arg Gin Phe Asp Phe Asp Gin Pro Ile Glu Arg Tyr Lys 145 150 155 160 Leu Gly Arg Ala Leu Tyr His Ile Ala Gin His Arg Gly Phe Lys Ser 165 170 175 Ser Lys Gly Glu Thr Leu Ser Gin Gin Glu Thr Asn Ser Lys Gin Ser 180 185 190 Leu Thr Asp Asp Thr Ala Asp Val Ala Gly Glu Met Lys Ala Ser Glu 195 200 205 Glu Lys Leu Ser Lys Gly Leu Ser Thr Tyr Met Lys Glu Asn Asn Leu 210 215 220 Leu Thr Val Gly Ala Ala Phe Ala Gin Leu Glu Asp Glu Gly Val Arg 225 230 235 240 Val Arg Asn Asn Asn Asp Tyr Arg Ala Ile Arg Ser Gin Phe Gin Arg 245 250 255 Glu Ile Glu Thr Ile Phe Lys Phe Gin Gin Gly Leu Ser Val Glu Asn 260 265 270 Glu Leu Tyr Glu Arg Leu Val Ser Glu Lys Lys Asn Ile Gly Thr Ile 275 280 285 Phe Tyr Lys Arg Pro Leu Arg Ser Gin Arg Gly Asn Val Gly Lys Cys 290 295 300 Thr Leu Glu Arg Thr Lys Pro Arg Cys Ala Ile Gly His Pro Leu Phe 305 310 315 320 Page 2775 of 3790 Glu Lys Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Val Arg Met 325 330 335 Ser Glu Glu Glu Gin Ala Glu Gin Leu Pro Met Lys Leu Arg Phe Glu 340 345 350 Leu Tyr Asn Asp Cys Phe Leu Ala Phe Val Arg Ala Glu Phe Lys Phe 355 360 365 Glu Asp Ile Arg Lys Tyr Leu Glu Lys Arg Leu Gly Val His Phe Ser 370 375 380 Tyr Asn Asp Lys Thr Ile Asn Tyr Lys Asp Ser Thr Ser Val Ala Gly 385 390 395 400 Cys Pro Ile Thr Ala Arg Phe Arg Lys Leu Leu Gly Glu Asp Trp Glu 405 410 415 Ser Phe His Val Asp Gly Gin Lys Gin Arg Gin Ala His Gly Lys Asn 420 425 430 Asn Ala Ser Phe His Thr Val Ser Tyr Ser Thr Asn Asp Ile Trp His 435 440 445 Phe Cys Tyr Asp Ala Glu Glu Pro Glu Ala Val Leu Ser Phe Ala Gin 450 455 460 Asp Asn Leu Lys Trp Glu Lys Lys Lys Ala Glu Glu Leu Val Arg Ile 465 470 475 480 Trp Ser Ala Ile Pro Gin Gly Tyr Ala Met Leu Ser Gin Lys Ala Ile 485 490 495 Arg Asn Ile Asn Lys Met Leu Ile Leu Gly Leu Lys Tyr Ser Asp Ala 500 505 510 Val Leu Leu Ala Lys Val Pro Glu Ile Val Glu Ile Thr Asp Gly Glu 515 520 525 Ile Leu Ser Val Thr Glu Asp Tyr His Arg Val Glu Ala Gin Val Gly 530 535 540 Tyr Glu Lys Gin Ile Asn Asn Ile Val Asn Ala Leu Ile Ala Lys Tyr 545 550 555 560 Lys Ser Ala Ser Glu Glu Tyr Arg Phe Ala Asp His Asn Tyr Glu Tyr Page 2777 of 3790 Gin Glu Leu Asp Gly Leu Lys Asn Gin Leu Asn Lys Glu Val Lys 1055 1060 1065 Page 2778 of 3790 Page 2779 of 3790 1136 443 PRT Prevotella disiens 1136 Page 2780 of 3790 Cys Ile Gly Lys Arg Glu Tyr Asp Leu Met Ala Gin Phe Tyr Arg Asp 100 105 110 Glu Glu Lys Tyr Arg Trp Glu Lys Lys Lys Lys Pro Phe Phe Lys Lys 115 120 125 Pro Trp Glu Thr Phe Thr Gin Asp Met Leu Ser Leu Lys Asp Glu Val 130 135 140 Leu Thr Val His Phe Asn Pro Ser Asn Phe Thr Lys Lys Ala His Lys 145 150 155 160 Lys Val Phe Thr Pro Lys Gly Ile Phe Val Ala Gin Gly Asp Cys Ala 165 170 175 Arg Val Lys Leu His Lys Glu Ser Tyr Phe Gly Ala Ile Glu Gin Lys 180 185 190 Gly Glu Ile Lys Tyr Val Met Arg Lys Glu Leu Ser Ala Leu Lys Ile 195 200 205 Glu Asp Ile Lys Asn Ile Val Asp Ala Val Val Lys Glu Lys Val Leu 210 215 220 Ala Val Val Lys Lys Lys Gly Phe Lys Gin Ala Met Ala Glu Pro Ile 225 230 235 240 Tyr Met Asn Glu Asp Lys Arg Ile Leu Ile Lys Lys Val Arg Leu Phe 245 250 255 Val Ser Gin Thr Asn Pro Leu Ile Val Lys Lys His Arg Asp Leu Ser 260 265 270 Ser Lys Glu Tyr Lys Gin Asn Tyr Tyr Val Asp Asn Glu Gly Asn Leu 275 280 285 Met Ile Ala Met Tyr Glu Gly Val Lys Lys Asn Gly Lys Ile Asp Arg 290 295 300 Glu Ile Thr Val Val Asn Asn Leu Glu Ala Ala Lys Phe Phe Arg Gin 305 310 315 320 Ser Gin Lys Asn Asn Ala Glu Lys Gin Leu Ile Ser His Leu Ser Pro 325 330 335 Lys Asn Gly Tyr Pro Leu Lys Thr Val Leu Thr Gin Lys Gin Leu Val Lys Ala Ala Glu Glu Glu Ile Ser Leu His Glu Leu Cys Arg Val Leu Page 2782 of 3790 115 120 125 Phe Met Met Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 130 135 140 Asn Lys Glu Asp Gly Lys Leu Phe Asp Gly Met Thr Val Ala Lys Lys 145 150 155 160 Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Phe Gin Leu Leu 165 170 175 Ser Ser Gly Lys Lys Phe Lys Gin Glu Tyr Tyr Arg Ser Asp Leu Lys 180 185 190 Glu Glu Phe Asp Arg Ile Trp Asn Glu Gin Gin Lys Tyr Tyr Pro Glu 195 200 205 Ile Leu Thr Asp Asp Phe Lys Gin Gin Leu Gin Gly Lys Ser Lys Gly 210 215 220 Asn Thr Ser Lys Ile Phe Leu Gly Lys Tyr Gly Ile Tyr Ser Ala Asp 225 230 235 240 Leu Lys Gly Leu Asp Arg Lys Leu Gin Pro Leu Lys Trp Arg Val Glu 245 250 255 Ala Leu Lys Gin Gin Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 260 265 270 Asp Leu Asn Gly Gin Ile Ala Ser Thr Ser Gly Leu Leu Gly Ala Ile 275 280 285 Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gin Thr Val Gly Gin 290 295 300 Tyr Leu Trp Thr Ser Leu Lys Glu Thr Pro His Val Ser Ile Lys Asn 305 310 315 320 Lys Pro Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 325 330 335 Glu Thr Gin Ala Thr Tyr His Lys Glu Leu Thr Pro Glu Leu Lys Gin 340 345 350 Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gin Arg Pro Leu Lys Ser Lys 355 360 365 Page 2783 of 3790 Lys Gly Leu Ile Ser Val Cys Glu Leu Glu Gin Arg Lys Val Lys Val 370 375 380 Thr Ile Asp Gly Lys Glu Lys Glu Ile Ser Ile Gly Pro Lys Val Ala 385 390 395 400 Pro Lys Ser Ser Pro Met Phe Gin Glu Phe Arg Ile Trp Gin Asn Leu 405 410 415 Asn Asn Ile Leu Leu Ile Asp Lys Gly Asn Asn Ser Ile His Pro Leu 420 425 430 Tyr Glu Glu Glu Lys Asn Leu Leu Tyr Glu Glu Leu Ser Val Lys Glu 435 440 445 Lys Leu Ser Lys Ala Glu Ala Leu Lys Val Leu Asn Lys Asn Ser Lys 450 455 460 Gin Trp Asp Leu Asn Tyr Lys Glu Ile Glu Gly Asn Arg Thr Gin Ala 465 470 475 480 Val Leu Tyr Asp Cys Tyr Asn Arg Ile Ile Val Met Thr Gly His Glu 485 490 495 Glu Tyr Asn Phe Lys Lys Leu Lys Ala Ser Glu Ile Arg Ser Tyr Val 500 505 510 Lys Thr Thr Phe Thr Gly Leu Gly Phe Asn Thr Asp Ile Leu Glu Phe 515 520 525 Asp Ser Ser Leu Thr Gly His Glu Leu Glu Lys Gin Pro Met Tyr Gin 530 535 540 Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asn Ser Arg Thr Gly 545 550 555 560 Asn Asp Ala Leu Leu Arg Lys Leu Glu Thr Ala Phe Gly Phe Pro Lys 565 570 575 Glu Tyr Ala Ala Val Leu Ser Asp Val Val Phe Glu Asp Ser Tyr Gly 580 585 590 Asn Leu Ser Val Lys Ala Met Arg Lys Ile Leu Pro His Leu Gin Ala 595 600 605 Gly Leu Asn Tyr Ser Gin Ala Cys Glu Glu Ala Gly Tyr Lys His Ser 610 615 620 Page 2784 of 3790 Arg Arg Ser Leu Thr Lys Asn Glu Leu Asp Gin Lys Glu Tyr Lys Glu 625 630 635 640 Lys Leu Glu Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 645 650 655 Lys Ile Leu Asn Gin Met Ile Asn Val Ile Asn Ala Val Ile Asp Glu 660 665 670 Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Leu Ala Arg Glu Leu Lys 675 680 685 Ile Gly Ala Ala Glu Arg Glu Asn Met Thr Arg Ser Ile Asn Gin Gly 690 695 700 Asn Ala Glu Asn Lys Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ala 705 710 715 720 Leu Ser Tyr Ile Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 725 730 735 Glu Leu Lys Ser Asn Gly Phe Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 740 745 750 Ser Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 755 760 765 Pro Lys Ala Arg Leu Phe Asp Asp Ser Leu Ser Asn Lys Thr Ile Glu 770 775 780 Ala Arg Asp Val Asn Ile Ala Lys Ser Asn Lys Thr Ala Phe Asp Phe 785 790 795 800 Ile Ser Glu Lys Tyr Asp Gin Gin Gly Ile Glu Ala Tyr Lys Lys Lys 805 810 815 Leu Asp Ile Leu Leu Gin Asp Gly Ser Ile Ser Lys Ala Lys Tyr Asn 820 825 830 Arg Leu Leu Met Lys Glu Ala Asp Ile Pro Ser Gly Phe Ile Asp Arg 835 840 845 Asp Leu Arg Asp Thr Gin Tyr Ile Ala Lys Lys Ala Tyr Glu Ile Leu 850 855 860 Ser Asp Leu Val Arg Asn Val Thr Pro Thr Thr Gly Ala Val Thr Ser 865 870 875 880 Page 2785 of 3790 Ala Leu Val Lys Thr Ile Glu Trp Glu Met Tyr His Pro Thr Arg Page 2787 of 3790 Leu Glu Gly Ile Val Lys Val Arg Ile Asn Cys Ile Gly Lys Ile 1355 1360 1365 Val Ala Val Gly Glu Tyr Asp 1370 1375 1138 1380 PRT Prevotella intermedia 1138 Page 2788 of 3790 Ala Glu Leu Glu Arg Ile Trp Asp Glu Gin Lys Lys Tyr Tyr Pro Glu 195 200 205 Ile Leu Thr Asp Glu Phe Lys Gin Gin Leu Glu Gly Lys Thr Lys Thr 210 215 220 Asn Thr Ser Lys Ile Phe Leu Ala Lys Tyr Gly Ile Tyr Ser Ala Asp 225 230 235 240 Leu Lys Gly Leu Asp Arg Lys Phe Gin Pro Leu Lys Trp Arg Val Glu 245 250 255 Ala Leu Gin Gin Gin Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 260 265 270 Asp Leu Lys Gly Gin Ile Ala Asn Thr Ser Gly Leu Leu Gly Ala Ile 275 280 285 Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gin Thr Val Gly Gin 290 295 300 Tyr Leu Trp Ala Ser Leu Glu Glu Asn Pro His Ile Ser Ile Lys Asn 305 310 315 320 Lys Pro Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 325 330 335 Glu Thr Gin Ala Ala Phe His Lys Gin Leu Thr Pro Glu Leu Lys Gin 340 345 350 Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gin Arg Pro Leu Lys Ser Lys 355 360 365 Lys Ser Leu Ile Ser Val Cys Glu Leu Glu Gin Arg Lys Val Lys Ala 370 375 380 Thr Ile Asp Gly Lys Glu Lys Glu Ile Thr Ile Gly Pro Lys Val Ala 385 390 395 400 Pro Lys Ser Ser Pro Val Phe Gin Glu Phe Arg Ile Trp Gin Asn Leu 405 410 415 Asn Asn Val Leu Leu Ile Asp Asn Asp Thr Asn Glu Lys Arg Pro Leu 420 425 430 Asp Glu Val Glu Arg Asn Leu Leu Tyr Lys Glu Leu Ser Ile Lys Ala 435 440 445 Page 2789 of 3790 Lys Leu Ser Lys Thr Glu Ala Leu Lys Ile Leu Asn Lys Lys Gly Lys 450 455 460 Gin Trp Asp Leu Asn Tyr Arg Glu Leu Glu Gly Asn Arg Thr Gin Ala 465 470 475 480 Ile Leu Phe Asp Cys Tyr Asn Arg Ile Ile Thr Leu Thr Gly His Glu 485 490 495 Glu Cys Asp Phe Lys Lys Ile Lys Ala Ser Glu Ile Arg His Tyr Val 500 505 510 Ser Thr Ile Phe Lys Asn Leu Gly Phe Ser Thr Glu Ile Leu Asp Phe 515 520 525 Asp Pro Ser Leu Lys Lys His Glu Leu Glu Lys Gin Pro Met Tyr Gin 530 535 540 Leu Trp His Leu Leu Tyr Ser Tyr Glu Ser Asp Asn Ser Arg Thr Gly 545 550 555 560 Asn Glu Ser Leu Leu Arg Lys Leu Glu Thr Thr Phe Gly Phe Pro Glu 565 570 575 Glu Tyr Ala Thr Val Leu Cys Asp Val Val Phe Glu Glu Asp Tyr Gly 580 585 590 Asn Leu Ser Val Lys Ala Met Arg Glu Ile Leu Pro Tyr Leu Gin Ala 595 600 605 Gly Asn Asp Tyr Ser Gin Ala Cys Ala Tyr Ala Gly Tyr Asn His Ser 610 615 620 Arg His Ser Leu Thr Lys Glu Glu Leu Asp Gin Lys Val Tyr Lys Glu 625 630 635 640 Arg Leu Glu Leu Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 645 650 655 Lys Ile Leu Asn Gin Met Ile Asn Val Ile Asn Ala Ile Ile Asp Glu 660 665 670 Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Met Ala Arg Glu Leu Lys 675 680 685 Ser Ser Ala Ala Asp Arg Lys Lys Thr Thr His Ala Ile Ser Gin Gly 690 695 700 Page 2790 of 3790 Asn Ala Glu Asn Gin Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ser 705 710 715 720 Leu Ser Tyr Ile Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 725 730 735 Glu Leu Glu Pro Asn Tyr Tyr Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 740 745 750 Thr Lys Asp Lys Leu Phe Ser Lys Asp Phe Asp Ile Glu His Ile Ile 755 760 765 Pro Lys Ala Arg Leu Phe Asp Asp Ser Phe Ser Asn Lys Thr Leu Glu 770 775 780 Ala Arg Asn Ile Asn Leu Glu Lys Ser Asn Lys Thr Ala Phe Asp Phe 785 790 795 800 Ile Lys Glu Lys Tyr Gly Glu Asp Gly Ala Glu Ala Tyr Lys Lys Lys 805 810 815 Leu Asp Met Leu Leu Glu Asn Asp Ala Ile Ser Arg Pro Lys Tyr Asn 820 825 830 Asn Leu Leu Arg Ala Glu Ala Asp Ile Pro Ser Asp Phe Ile Asn Arg 835 840 845 Asp Leu Arg Asn Thr Gin Tyr Ile Ala Lys Lys Ala Cys Glu Ile Leu 850 855 860 Gly Glu Leu Val Lys Thr Val Thr Pro Thr Thr Gly Lys Ile Thr Asn 865 870 875 880 Arg Leu Arg Glu Asp Trp Gin Leu Val Asp Val Met Lys Glu Leu Asn 885 890 895 Phe Glu Lys Tyr Glu Lys Leu Gly Leu Thr Glu Ile Val Glu Asp Arg 900 905 910 Asp Gly Arg Lys Ile Lys Arg Ile Lys Asp Trp Thr Lys Arg Asn Asp 915 920 925 His Arg His His Ala Met Asp Ala Leu Ala Ile Ala Phe Thr Lys Pro 930 935 940 Ser Phe Ile Gin Tyr Leu Asn Asn Leu Asn Ala Arg Ser Asn Lys Gly 960 945 950 Page 2791 of 3790 955 1139 129 PRT Prevotella multiformis 1139 Met Gin Lys Gly Gly Thr Gly Cys Lys Ile Asn Arg Gin Thr Val Gly 15 10 15 Page 2793 of 3790 Page 2794 of 3790 His Ala Met Asp Ala Leu Val Ile Ala Cys Ala Ser Arg Asn Ile Ile 100 105 110 Gly Tyr Leu Asn Asn Glu Ser Ala Glu Ser Pro Glu Lys Arg Glu Asp 115 120 125 Leu Arg Arg Lys Leu Cys Asp Lys Asn His Ile Ile Arg Lys Pro Trp 130 135 140 Glu Ser Phe Thr Gin Asp Ala Arg Ala Ala Leu Glu Asp Ile Val Val 145 150 155 160 Ser Phe Lys Asn Tyr Val Arg Ile Ile Asn Lys Ala Thr Asn Tyr Tyr 165 170 175 Glu Arg Tyr Asp Ala Asp Gly Arg Lys Thr Lys Ala Glu Gin Lys Gly 180 185 190 Gly Glu Met Trp Ala Val Arg Lys Pro Met His Glu Ala Thr Tyr Tyr 195 200 205 Gly Lys Val Asn Leu Arg Arg Lys Glu Arg Val Ser Leu Lys Ala Ala 210 215 220 Leu Glu Asp Ile Pro Ser Ile Cys Asn Arg Asp Leu Arg Asp Tyr Ile 225 230 235 240 Asn Gly Leu Val Glu Lys His Phe Asn Lys Glu Gin Val Leu Ala Gin 245 250 255 Phe Arg Ser Val Gly Asn Arg Trp Asn Lys Gin His Ile Asp Lys Val 260 265 270 Asp Val Trp Arg Phe Ser Asp Gly Lys Glu Glu Met Val Ala Thr Arg 275 280 285 Lys Pro Leu Asp Thr Ser Phe Asp Ala Lys Arg Ile Glu Ala Val Thr 290 295 300 Asp Thr Gly Ile Gin Arg Ile Leu Ser Asn Tyr Leu Glu Ala Lys Gly 305 310 315 320 Gly Asp Pro Lys Ile Ala Phe Thr Pro Glu Gly Ile Ala Asp Met Asn 325 330 335 Gin His Ile Thr Ala Tyr Asn Asn Gly Lys Gin His Lys Pro Ile Leu 340 345 350 Page 2795 of 3790 Page 2796 of 3790 Arg Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Ser Asn 35 40 45 Phe Glu Lys Gly Lys Ala Ile Thr Thr Asn Ala Asp Arg Gin Leu Arg 50 55 60 His Gly Ala Arg Ile Asn Leu Gin Arg Tyr Lys Leu Arg Arg Gin Asn 65 70 75 80 Leu His Asp Cys Leu Gin Lys Gin Gly Trp Leu Gly Thr Glu Ala Met 85 90 95 Tyr Glu Glu Gly Lys Ala Ser Thr Phe Glu Thr Tyr Lys Leu Arg Ala 100 105 110 Lys Ala Ala Glu Glu Glu Ile Ser Leu His Glu Phe Ala Arg Val Leu 115 120 125 Phe Met Leu Asn Lys Lys Arg Gly Tyr Lys Ser Asn Arg Lys Ala Asn 130 135 140 Asn Lys Glu Asp Gly Gin Leu Phe Asp Gly Met Thr Ile Ala Lys Lys 145 150 155 160 Leu Tyr Glu Glu His Leu Thr Pro Ala Glu Tyr Ser Leu Gin Leu Leu 165 170 175 Asn Lys Gly Lys Lys Phe Thr Gin Gly Tyr Tyr Arg Ser Asp Leu Asn 180 185 190 Ala Glu Leu Glu Arg Ile Trp Asp Glu Gin Lys Lys Tyr Tyr Pro Glu 195 200 205 Ile Leu Thr Asp Glu Phe Lys Gin Gin Leu Glu Gly Lys Thr Lys Thr 210 215 220 Asn Thr Ser Lys Ile Phe Leu Ala Lys Tyr Gly Ile Tyr Ser Ala Asp 225 230 235 240 Leu Lys Gly Leu Asp Arg Lys Leu Gin Pro Leu Lys Trp Arg Val Glu 245 250 255 Ala Leu Lys Gin Gin Val Asp Lys Glu Val Leu Ala Phe Val Ile Ser 260 265 270 Asp Leu Lys Gly Gin Ile Ala Asn Thr Ser Gly Leu Leu Gly Ala Ile 275 280 285 Page 2797 of 3790 Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Gin Thr Val Gly Gin 290 295 300 Tyr Leu Trp Ala Ser Leu Glu Glu Asn Pro His Ile Ser Ile Lys Asn 305 310 315 320 Lys Pro Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu Lys Ile Trp 325 330 335 Glu Thr Gin Ala Thr Phe His Lys Gin Leu Thr Pro Glu Leu Lys Gin 340 345 350 Glu Ile Arg Asp Ile Ile Ile Phe Tyr Gin Arg Pro Leu Lys Ser Lys 355 360 365 Lys Ser Leu Ile Ser Val Cys Glu Leu Glu Gin Arg Lys Val Lys Ala 370 375 380 Thr Ile Asp Gly Lys Glu Lys Glu Ile Thr Ile Gly Pro Lys Val Ala 385 390 395 400 Pro Lys Ser Ser Pro Val Phe Gin Glu Phe Arg Ile Trp Gin Asn Leu 405 410 415 Asn Asn Val Leu Leu Ile Asp Asn Asp Thr Asn Glu Lys Arg Pro Leu 420 425 430 Asp Glu Asp Glu Arg Tyr Leu Leu Tyr Lys Glu Leu Ser Ile Lys Ala 435 440 445 Lys Leu Ser Lys Thr Glu Ala Leu Lys Ile Leu Asn Lys Lys Gly Lys 450 455 460 Gin Trp Asp Leu Asn Tyr Lys Glu Leu Glu Gly Asn Arg Thr Gin Ala 465 470 475 480 Ile Leu Phe Asp Cys Tyr Asn Arg Ile Ile Thr Leu Thr Gly His Glu 485 490 495 Glu Cys Asp Phe Lys Lys Ile Lys Ala Ser Glu Ile Arg His Tyr Val 500 505 510 Ser Thr Ile Phe Lys Asn Leu Gly Phe Ser Thr Glu Ile Leu Asp Phe 515 520 525 Asp Pro Ser Leu Glu Lys His Glu Leu Glu Lys Gin Pro Met Tyr Gin Page 2799 of 3790 Lys Val Met Thr Gin Asn Val Asn Lys Ile Lys Thr Lys His Gly 1010 1015 1020 Ile Ile Lys Lys Ile Gin Leu Thr Pro Arg Gly Pro Leu His Asn 1025 1030 1035 Page 2800 of 3790 Page 2801 of 3790 1142 1506 PRT Prevotella nigrescens 1142 Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Pro Asn Ser Ile Gly Trp 15 10 15 Ala Lys Val Glu Val Asp Asp Glu Gly Asn Tyr Leu Arg Asn Ile Lys 20 25 30 Leu Gly Ser Arg Ile Ile Pro Met Thr Gin Asp Met Leu Gly Asp Phe 35 40 45 Asp Lys Gly Val Lys Val Ser Gin Thr Ala Ile Arg Thr Asp Phe Arg 50 55 60 Gly Asn Arg Arg Leu Ile Glu Arg His Leu Leu Arg Arg Glu Arg Leu 65 70 75 80 His Arg Val Leu His Ala Leu Lys Phe Leu Pro Lys His 85 90 Tyr Glu Asp 95 Ala Ile Gly Trp Asp Arg Asn Glu Pro Ala Thr Tyr Gly Lys Phe Val 100 105 110 Page 2802 of 3790 Asn Asn Ser Glu Pro Lys Leu Ala Trp Glu Arg Gin Glu Asp Gly Ser 115 120 125 Met Arg Phe Leu Phe Met Glu Ser Phe Asn Glu Met Val Ala Asp Phe 130 135 140 Ala Gin Asn Gin Pro Ser Leu Val Ser Asp Gly Lys Lys Ile Pro Leu 145 150 155 160 Asp Trp Thr Ile Tyr Tyr Leu Arg Lys Lys Ala Leu Thr Arg Pro Ile 165 170 175 Lys Lys Glu Glu Leu Ala Trp Ile Leu Leu Asn Phe Asn Gin Lys Arg 180 185 190 Gly Tyr Tyr Gin Leu Arg Gly Glu Glu Glu Glu Asp Asn Leu Thr Lys 195 200 205 Arg Lys Glu Tyr Tyr Lys Leu Lys Val Val Gly Val Glu Ala Asp Gly 210 215 220 Ala Pro Lys Gly Gly Lys Thr Trp Tyr Asn Ile His Leu Glu Asn Gly 225 230 235 240 Trp Thr Ala Arg Cys Gin Ser Lys Ile Pro Leu Asp Asp Trp Val Gly 245 250 255 Lys Val Lys Glu Tyr Ile Val Thr Thr Glu Tyr Glu Asp Asp Gly Lys 260 265 270 Thr Pro Lys Cys Asp Lys Glu Gly Lys Val Lys Arg Ser Phe Lys Ser 275 280 285 Pro Glu Lys Asp Asp Trp Gin Leu Ile Lys Thr Arg Thr Glu Lys Phe 290 295 300 Ile Asp Asp Ser Asn Lys Thr Val Gly Ala Phe Ile Tyr Asp Tyr Leu 305 310 315 320 Leu Glu Lys Pro Phe Asp Lys Ile Arg Gly Lys Tyr Ile Arg Thr Ile 325 330 335 Glu Arg Lys Tyr Tyr Lys Asn Glu Leu Arg Glu Ile Leu Arg Glu Gin 340 345 350 Thr Lys Tyr His Glu Gly Leu His Ser Leu Glu Ala Leu Lys Ile Cys Page 2803 of 3790 355 360 365 Ala Glu Glu Leu Tyr Lys Asn Asn Gin Gin His Gin Glu Tyr Leu Leu 370 375 380 Lys Lys Asp Met Thr Phe Leu Leu Leu Asn Asp Leu Ile Phe Tyr Gin 385 390 395 400 Arg Pro Leu Lys Ser Lys Lys Ser Leu Ile Ala Asp Cys Pro Tyr Glu 405 410 415 Val Tyr Lys Tyr Asp Asp Lys Leu Thr Gly Lys Lys Gly Gin Lys Lys 420 425 430 Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gin Glu Phe Arg Leu 435 440 445 Trp Gin Phe Ile Ala Asn Leu Arg Leu Phe Ser Val Thr Asp Gly Lys 450 455 460 Glu Val Thr Ala Glu Tyr Leu Lys Thr Glu Glu Asp Tyr Val Arg Leu 465 470 475 480 Phe Ser Phe Leu Asn Asp Arg Lys Asp Ile Lys Gin Glu Thr Phe Leu 485 490 495 Arg Ser Phe Leu Lys Leu Lys Lys Glu Ser Ile Gly Ser Glu Lys Ile 500 505 510 Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Ala Asn Lys Ser Tyr Pro 515 520 525 Cys Asn Ala Thr Arg His Glu Leu Leu Leu Ala Phe Asp Arg Ala Asp 530 535 540 Ile Pro Arg Glu Leu Leu Asp Val Glu Glu Arg Glu Tyr Arg Leu Trp 545 550 555 560 His Leu Leu Tyr Ser Ile Glu Ala Lys Glu Glu Thr Glu Ser Ala Leu 565 570 575 Arg Lys Leu Lys Ala Asn Lys Ala Phe Gly Asp Leu Asn Ile Asp Asp 580 585 590 Ala Phe Val Asn Ser Phe Leu Lys Ile Lys Pro Phe Glu Lys Glu Tyr 595 600 605 Page 2804 of 3790 Gly Ala Tyr Ser Glu Lys Ala Ile Lys Lys Leu Leu Ala Val Met Arg 610 615 620 Arg Gly Ser Leu Trp Lys Glu Ala Asp Ile Cys Glu Ala Thr Lys Gin 625 630 635 640 Asn Ile Ala Lys Ile Leu Gin Asn Asp Ile Asp Glu Lys Leu Lys Lys 645 650 655 Lys Ile Glu Ala Ala Val Ser Ser Phe Asn Lys Leu Ser Asp Phe Gin 660 665 670 Gly Leu Pro Thr Trp Leu Ala Cys Tyr Val Val Tyr Gly Arg His Ser 675 680 685 Glu Ala Ala Gin Ile Gin Cys Trp Gin Ser Pro Glu Asp Leu Lys Thr 690 695 700 Tyr Ile Asn Lys Phe Lys Gin His Ser Leu Arg Asn Pro Ile Val Glu 705 710 715 720 Gin Cys Leu Leu Glu Thr Leu Arg Thr Val Tyr Asp Ile Trp Lys Asp 725 730 735 Ala Gly Gin Ile Asp Glu Ile His Ile Glu Leu Gly Arg Asn Met Lys 740 745 750 Ser Thr Ala Glu Gin Arg Ala Arg Lys Thr Lys Asp Ile Leu Arg Asn 755 760 765 Glu Asn Thr Asn Leu Arg Ile Lys Asn Leu Leu Val Glu Leu Lys Asn 770 775 780 Asp Asp Lys Ile Glu Asn Val Arg Pro Tyr Ser Pro Ser Gin Gin Glu 785 790 795 800 Ile Leu Arg Ile Tyr Glu Glu Gly Ala Leu Gin Glu Leu Ser Lys Glu 805 810 815 Asp Glu Met Phe Glu Asp Ile Ser Lys Ile Ser Lys Met Ala Gin Pro 820 825 830 Ser Pro Thr Glu Leu Ser Arg Tyr Lys Leu Trp Leu Glu Gin Lys Tyr 835 840 845 Arg Ser Pro Tyr Thr Gly Arg Val Ile Pro Leu Ser Lys Leu Phe Thr 850 855 860 Page 2805 of 3790 Asp Leu Arg Lys Lys Leu Cys Asp Glu Lys Arg Lys Ile Arg Lys 1100 1105 1110 Page 2806 of 3790 Gin Thr Gly Asn Lys Ala Thr Lys Phe Val Val Ala Glu Lys Gly Val Ile Lys 1505 1143 774 PRT Prevotella oulorum 1143 Met Glu Gin Cys Ile Leu Glu Thr Leu Arg Thr Val Tyr Asp Ile Trp 15 10 15 Lys Glu Ala Gly Gin 20 Ile Asp Glu Ile His Val Glu Leu Gly Arg Glu 30 Met Lys Gin Thr Ala Glu Gin Arg Ala His Leu Thr Glu Lys Val Leu Page 2808 of 3790 40 45 Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser Leu Leu Met Glu Leu 50 55 60 Lys Asn Asp Ala Asp Met Lys Asp Val Arg Pro Tyr Ser Pro Met Gin 65 70 75 80 Gin Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala Leu Gin Thr Leu Ser 85 90 95 Lys Asp Asp Ala Ala Phe Thr Glu Ile Met Lys Ile Ser Lys Met Ala 100 105 110 Gin Pro Ser Ala Ser Glu Leu Gin Arg Tyr Arg Leu Trp Leu Glu Gin 115 120 125 Lys Tyr Arg Ser Pro Tyr Thr Gly Lys Pro Ile Ser Leu Ser Lys Leu 130 135 140 Phe Thr Ser Ala Tyr Gin Ile Glu His Ile Ile Pro Lys Lys Arg Tyr 145 150 155 160 Phe Asp Asp Ser Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val Asn 165 170 175 Gly Lys Lys Asp Ser Met Leu Ala Tyr Glu Phe Ile Lys Asp Cys Gly 180 185 190 Gly Asp Val Ile His Cys Thr Thr Leu Gly Asp Val Thr Ile Leu Ser 195 200 205 Glu Ala Glu Tyr Lys Ala Leu Val Thr Glu Leu Tyr Ala Asn Asn Lys 210 215 220 Ser Lys Lys Asp Lys Leu Leu Met Glu Asp Ile Pro Gin Asp Phe Ile 225 230 235 240 Asn Arg Gin Leu Asn Asp Ser Arg Tyr Ile Ser Arg Val Val Met Thr 245 250 255 Leu Leu Ser Asn Ile Val Arg Ile Glu Gly Glu Glu Glu Ala Thr Ser 260 265 270 Lys Phe Val Ile Pro Cys Ser Gly Gly Ile Thr Asp Lys Leu Lys Lys 275 280 285 Page 2809 of 3790 Asp Trp Gly Leu Asn Asp Val Trp Asn Asn Ile Val Tyr Pro Arg Phe 290 295 300 Glu Arg Leu Asn Ala Leu Thr Asn Thr Ser Asp Phe Gly Gin Trp Glu 305 310 315 320 Asn Lys Glu Gly Lys Arg Val Phe Gin Thr Ser Val Pro Leu Glu Leu 325 330 335 Gin Arg Gly Tyr Gin Lys Lys Arg Ile Asp His Arg His His Ala Met 340 345 350 Asp Ala Leu Val Ile Ala Cys Ala Ser Arg Lys Ile Ile Asn Tyr Leu 355 360 365 Asn Asn Gin Glu Ala Asn Asp Pro Thr Lys Gin Glu Asn Ala Arg Lys 370 375 380 Gin Leu Cys Ile Lys Ser Arg Ile Ile Arg Lys Pro Trp Glu Thr Phe 385 390 395 400 Thr Gin Asp Ala Tyr Lys Ala Leu Asp Asn Ile Val Val Ser Phe Lys 405 410 415 Asn Tyr Val Arg Val Ile Asn Lys Ala Thr Asn Tyr Tyr Glu Arg Tyr 420 425 430 Asn Ala Asp Gly Lys Lys Ala Val Asp Glu Gin Lys Gly Glu Ala Met 435 440 445 Trp Ala Ile Arg Lys Pro Met His Lys Asp Thr Val Phe Gly His Val 450 455 460 Asn Leu Arg Arg Lys Ala Val Val Lys Leu Lys Asp Ala Leu Glu Asn 465 470 475 480 Ile Pro Ala Ile Cys Asp Lys Thr Leu Arg His Tyr Ile Gin Asp Leu 485 490 495 Gin Lys Lys His Phe Asn Thr Lys Gin Leu Leu Ala His Phe Lys Ser 500 505 510 Ile Asn Tyr Arg Leu Asn Lys Gin Ala Val Asp Lys Val Glu Val Trp 515 520 525 Gin Tyr Ser Asp Asp Lys Glu Gin Leu Ala Ala Thr Arg Lys Pro Leu 530 535 540 Page 2810 of 3790 Page 2811 of 3790 PRT Prevotella oulorum Page 2812 of 3790 Trp Thr Tyr His Arg Gin Ser Lys Ile Pro Leu Asp Asp Trp Val Gly 245 250 255 Lys Val Arg Ala Phe Ile Val Thr Thr Glu Tyr Glu Lys Asp Gly Thr 260 265 270 Thr Pro Lys Lys Asp Lys Glu Gly Asn Val Lys Arg Ser Phe Arg Ser 275 280 285 Pro Asp Glu Lys Asp Trp Gly Leu Arg Lys Lys Gin Thr Glu His Ser 290 295 300 Leu Glu Ala Ser Gly Thr Pro Val Gly Ala Phe Ile Tyr Asp His Leu 305 310 315 320 Leu Lys Glu Pro Ser Asp Lys Ile Arg Gly Lys Phe Ile His Thr Ile 325 330 335 Glu Arg Lys Tyr Tyr Lys Gin Glu Leu Ala Ala Ile Leu Arg Glu Gin 340 345 350 Ser Lys His His Glu Lys Leu Cys Ser Lys Asp Met Leu Lys Ala Cys 355 360 365 Ile Glu Glu Leu Tyr Pro Asn Asn Pro Leu His Arg Glu Ser Leu Leu 370 375 380 Lys Lys Asp Met Pro Tyr Leu Leu Ile Glu Asp Leu Ile Phe Tyr Gin 385 390 395 400 Arg Pro Leu Lys Ser Lys Lys Ser Leu Ile Ala Glu Cys Pro Tyr Glu 405 410 415 Ala Tyr Ser Tyr Val Asp Lys Glu Thr Gly Glu Met Lys Arg Gin Gly 420 425 430 Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gin Glu Phe Arg Leu 435 440 445 Trp Gin Leu Ile Ala Asn Leu Arg Leu Arg Asn Arg Ser Asp Glu Arg 450 455 460 Asp Val Thr Ala Glu Tyr Leu Pro His Gin Glu Asp Tyr Val Arg Leu 465 470 475 480 Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gin Glu Thr Leu Leu 485 495 Page 2813 of 3790 490 Thr Pro Glu 690 1145 242 PRT Prevotella saccharolytica 1145 Met Lys Leu Val Leu Gly Leu Asp Leu Gly Val Gly Ser Val Gly Trp Arg Tyr Page 2815 of 3790 1146 1174 PRT Prevotella sp. Page 2816 of 3790 Ala Leu Arg Arg Phe Ala Leu Thr His Gly Val Ser Ser Val Asp Ala 225 230 235 240 Phe Val Glu Ser Phe Leu Lys Val Lys Pro Phe Lys Lys Glu Tyr Gly 245 250 255 Ala Tyr Ser Glu Lys Ala Thr Lys Lys Leu Leu Gin Val Met Arg Leu 260 265 270 Gly Lys Tyr Trp Cys Gly Asp Glu Leu Pro Glu Pro Ala Lys Arg Thr 275 280 285 Lys Gly Asn Lys Gin Ala Val Tyr Asp Glu Met Ala His Arg Gly Ile 290 295 300 Cys Lys Gin Thr Leu Gin Asn Ile Ser Asn Ile Ile Glu Glu Asn Ile 305 310 315 320 Asp Glu Arg Leu Met Gly Ala Leu Leu Asn Pro Glu Arg Pro Leu Thr 325 330 335 Glu Leu Ser His Phe Gin Gly Leu Ser Val Ser Asp Ala Cys Tyr Val 340 345 350 Val Tyr Gly Arg His Ser Glu Val Ala Glu Ile Val Lys Trp Lys Asp 355 360 365 Ala Asp Glu Leu Asn Thr Phe Ile Asn Asn Phe Lys Gin His Ser Met 370 375 380 Arg Asn Pro Ile Val Glu Gin Cys Val Leu Glu Thr Leu Arg Thr Val 385 390 395 400 Arg Asp Val Trp Glu Gin Glu Gly Gin Ile Asp Glu Ile His Val Glu 405 410 415 Leu Gly Arg Asn Met Lys Arg Thr Ala Glu Gin Arg Ala Arg Asp Thr 420 425 430 Gin Ala Ile Gin Arg Asn Glu Asn Thr Asn Met Arg Ile Ser Leu Leu 435 440 445 Leu Thr Glu Leu Lys Asn Asp Pro Ser Ile Ser Asp Val Arg Pro Tyr 450 455 460 Ser Pro Ser Gin Arg Glu Leu Leu Lys Ile Tyr Glu Glu Gly Ala Leu 465 470 475 480 Page 2817 of 3790 Glu Asn Leu Thr Asn Gin Asp Glu Asp Ile Ala Lys Ile Ser Arg Leu 485 490 495 Ala Gin Pro Ser Ala Ser Glu Leu Arg Arg Tyr Lys Leu Trp Leu Asp 500 505 510 Gin Lys Tyr Val Ser Pro Tyr Thr Gly Arg Pro Ile Pro Leu Ala Lys 515 520 525 Leu Phe Thr Pro Ala Tyr Glu Ile Glu His Ile Ile Pro Gin Ser Arg 530 535 540 Tyr Phe Asp Asn Ser Phe Ser Asn Lys Val Ile Cys Glu Ala Glu Val 545 550 555 560 Asn Lys Leu Lys Asp Asn Leu Leu Gly Met Glu Phe Ile Lys Lys Phe 565 570 575 Gly Gly Lys Thr Lys Gly Ile Leu Asp Glu Glu Ala Tyr Lys Leu His 580 585 590 Val Thr Thr Asn Tyr Ala His Asn Pro Ala Lys Arg Ser Lys Leu Leu 595 600 605 Met Glu Asp Leu Pro Thr Asp Phe Asn Ser Arg Gin Leu Asn Asp Thr 610 615 620 Arg Tyr Ile Ser Lys Thr Val Met Ala Leu Leu Ser Asn Val Val Arg 625 630 635 640 Glu Glu Gly Glu Arg Glu Thr Arg Ser Lys His Val Val Val Cys Thr 645 650 655 Gly Gly Val Thr Asp Thr Leu Lys Lys Asp Trp Gly Leu His Asp Val 660 665 670 Trp His Asn Leu Val Tyr Pro Arg Phe Ile Arg Leu Asn Asn Leu Thr 675 680 685 Gly Ser Gin Asn Phe Gly Tyr Trp Arg Tyr Leu Asn Glu Glu Asn Ser 690 695 700 Lys Lys Gly Glu Asp Ser Lys Lys Val Phe Gin Ile Thr Leu Pro Pro 705 710 715 720 Glu Cys Gin Arg Gly Phe Val Lys Lys Arg Ile Asp His Arg His His 725 730 735 Page 2818 of 3790 Ala Met Asp Ala Leu Val Ile Ala Cys Ala Ser Ala Asn Ile Val Asn 740 745 750 Tyr Leu Asn Asn Gin Ser Ala Ala Asn Pro His Ile His Glu Asn Leu 755 760 765 Gin Arg Leu Leu Cys Asp Arg Lys Arg Glu Ile Arg Lys Pro Trp Pro 770 775 780 Thr Phe Thr Gin Asp Ala Gin Ala Ala Leu Lys Asp Leu Val Val Ser 785 790 795 800 Phe Lys Asn Thr Val Arg Val Val Asn Lys Ala Ser Asn Thr Tyr Leu 805 810 815 Arg Tyr Asp Lys Asp Gly Lys Lys Lys Arg Phe Lys Gin Glu Gly Glu 820 825 830 Gly Leu Lys Ala Ile Arg Lys Pro Met His Lys Glu Thr Tyr Tyr Gly 835 840 845 Glu Val Asn Leu Ile Arg Lys Glu Met Val Pro Leu Lys Arg Ala Leu 850 855 860 Asp Asp Val Asn Ala Ile Val Asp Lys Glu Leu Arg Ala Ser Ile Lys 865 870 875 880 Gly Leu Leu Arg Asp Gly Phe Asn Pro Gin Gin Val Leu Ala Asn Phe 885 890 895 Lys Ala Lys Asp Phe Lys Phe Asp Lys Arg Asp Ile Lys Lys Val Glu 900 905 910 Val Tyr Val Ser Ser Glu Lys Ser Thr Pro Met Val Ala Thr Arg Lys 915 920 925 Ser Leu Asp Thr Ser Phe Asn Ala Lys Arg Ile Ala Asp Ile Thr Asp 930 935 940 Thr Gly Ile Gin Lys Ile Leu Leu Asn Tyr Leu Lys Ala Asn Asp Asn 945 950 955 960 Ser Pro Glu Gin Ala Phe Thr Pro Glu Gly Ile Ala Tyr Leu Asn Glu 965 970 975 His Ile Ala Glu Tyr Asn Asp Gly Lys Pro His Gin Pro Ile Leu Lys 980 Page 2819 of 3790 985 990 Val Arg Val Ser Glu Val Lys Gly Ala Lys Phe Ala Val Gly Gin Thr 995 1000 1005 Arg 1147 992 PRT Prevotella sp. 1147 Met Ile Thr Arg Ile Leu Gly Leu Asp Thr Gly Thr Asn Ser Leu Ala Page 2821 of 3790 Gin Arg Lys Gly Val Gly Lys Cys Thr Phe Glu Pro Lys Lys Pro Arg 260 265 270 Cys Ala Glu Ser His Pro Asp Tyr Glu Ala Phe Arg Met Leu Cys Phe 275 280 285 Leu Asn Asn Val Lys Ile Gin Thr Pro Asn Asp Thr Ser Leu Arg Pro 290 295 300 Leu Asn Glu Asp Glu Arg Glu Lys Ile Trp Pro Ile Phe Phe Arg Lys 305 310 315 320 Ser Lys Pro Asn Phe Asp Phe Glu Asp Ile Ala Lys Ala Leu Ala Gly 325 330 335 Lys Asn Asn Tyr Ala Trp Tyr Lys Asp Ala Gly Glu Lys Pro Phe Lys 340 345 350 Phe Asn Tyr Arg Met Gin Gin Gly Val Ser Gly Cys Pro Val Thr Ala 355 360 365 Gin Leu Ile Asp Ile Phe Gly Ser Asp Trp Gin Thr Ala Ile Ala Glu 370 375 380 Thr Tyr Thr Ala Val Glu Lys Lys Asn Gly Thr Lys Thr Ile Asp Glu 385 390 395 400 Met Ala Asp Asp Val Trp Asn Val Leu Tyr Ser Phe Ser Ser Lys Asp 405 410 415 Lys Leu Lys Ala Phe Ala Thr Glu Lys Leu Gin Leu Asp Glu Ala Ser 420 425 430 Ala Thr Lys Phe Ala Asn Ala Lys Leu Pro His Gly Phe Ala Ser Leu 435 440 445 Ser Leu Lys Ala Ile Arg Asn Ile Leu Pro Phe Leu Arg Gin Gly Phe 450 455 460 Ile Tyr Ala His Ala Val His Leu Ala Lys Ile Pro Asp Ile Val Thr 465 470 475 480 Lys Ala Val Trp Asn Asp Ala Asp Lys Arg Glu Met Ile Leu Ser Gly 485 490 495 Leu Met Glu Ile Ile Glu Asn Tyr Asn Pro Lys Asp Arg Gly Val Glu 500 505 510 Page 2822 of 3790 Gly Thr Ile Asp Phe Cys Ile Lys Ser His Leu Gin Asp Val Ile Asp 515 520 525 Leu Arg Pro Gly Ala Ala Asp Ala Leu Tyr His Pro Ser Met Ile Glu 530 535 540 Thr Tyr Pro Asp Ala Lys Leu Asn Lys Met Gly Val Phe Gin Leu Gly 545 550 555 560 Ser Pro Arg Thr Asn Ala Ile Arg Asn Pro Met Ala Met Arg Ser Leu 565 570 575 His Ile Leu Arg Ser Val Val Asn Gin Leu Leu Arg Asp Gly Ile Ile 580 585 590 Asp Arg Asp Thr Glu Val His Val Glu Tyr Ala Arg Glu Leu Asn Asp 595 600 605 Ala Asn Lys Arg Lys Ala Ile Ala Asp Tyr Gin Arg Glu Gin Glu Lys 610 615 620 Lys Arg Lys Gin Tyr Arg Asp Asp Ile Ile Ala Leu Tyr Lys Ser Glu 625 630 635 640 Cys His Lys Glu Ile Glu Pro Thr Asp Thr Asp Ile Leu Lys Phe Gin 645 650 655 Leu Trp Glu Glu Gin Asn His Leu Cys Leu Tyr Thr Gly Thr Gin Ile 660 665 670 Gly Ile Cys Asp Phe Leu Gly Asp Asn Pro Lys Phe Asp Ile Glu His 675 680 685 Thr Val Pro Arg Ser Val Gly Gly Asp Ser Thr Gin Met Asn Leu Thr 690 695 700 Leu Cys Asp Ala Thr Phe Asn Arg Gin Val Lys Gly Ala Gin Leu Pro 705 710 715 720 Ser Gin Leu Ser Asn His Ala Asp Ile Leu Val Arg Ile Asp His Trp 725 730 735 Lys Ser Lys Cys Glu Asp Leu Arg Lys Gin Leu Asp Lys Ile Arg Thr 740 745 750 Tyr Gly Gly Met Glu Lys Asn Met Lys Asp Arg Leu Ile Gin Lys Arg 755 760 765 Page 2823 of 3790 His Arg Leu Lys Met Asp Leu Asp Tyr Trp Gin Gly Lys Tyr Ser Arg 770 775 780 Phe Thr Met Thr Glu Val Pro Glu Gly Phe Ser Arg Arg Gin Gly Ala 785 790 795 800 Gly Ile Gly Leu Val Ser Lys Tyr Ala Gly Leu Phe Leu Lys Ser Leu 805 810 815 Phe His Asn Glu Gin Asn Pro Asn Lys Ser Asn Val Tyr Val Val Lys 820 825 830 Gly Val Thr Thr Ala Glu Phe Arg Arg Met Trp Gly Leu Gin Gly Glu 835 840 845 Tyr Glu Lys Lys Ser Arg Leu Asn His Cys His His Cys Ile Asp Ala 850 855 860 Ile Thr Ile Ala Cys Ile Gly Lys Ala Glu Tyr Asp Lys Met Ala Gin 865 870 875 880 Tyr Tyr His Asp Glu Glu Leu Phe Gin Trp Arg Gly Thr Thr Thr Lys 885 890 895 Pro His Phe Asn Lys Pro Trp Pro Thr Phe Thr Glu Asp Val Leu Ala 900 905 910 Ile Glu Gin Ser Leu Leu Val Lys His Leu Thr Lys Asp Asn Met Pro 915 920 925 Lys Gin Ala Lys Lys Arg Val Arg Thr Ala Thr Gly Lys Tyr Leu Ala 930 935 940 Gin Gly Asp Thr Ala Arg Gly Ser Leu His Lys Asp Thr Tyr Tyr Gly 945 950 955 960 Ala Ile Glu Gin Asn Gly Glu Ile Arg Tyr Val Leu Arg Lys Pro Leu 965 970 975 Asn Lys Phe Glu Asn Glu Ala Glu Leu Glu Lys Ile Val Asp Gin Ala 980 985 990 1148 1375 PRT Prevotella sp. Page 2824 of 3790 Thr Lys Gly Leu Asp Arg Arg Leu Gin Pro Leu Lys Trp Arg Val Glu Page 2826 of 3790 Glu Cys Asn Phe Lys Lys Leu Lys Ala Ser Asp Ile Arg His Tyr Val 500 505 510 Lys Met Ile Phe Lys Asn Leu Ala Phe Asn Thr Asp Ile Leu Cys Phe 515 520 525 Asp Ser Ser Leu Lys Gly His Glu Leu Glu Arg Gin Pro Met Cys Gin 530 535 540 Leu Trp His Leu Leu Tyr Ser Tyr Glu Gly Asp Asn Ser Arg Thr Gly 545 550 555 560 Asn Asp Ala Leu Leu Arg Lys Leu Glu Thr Ser Phe Gly Phe Pro Lys 565 570 575 Glu Tyr Ala Ala Val Leu Ala Asp Val Ile Phe Glu Asp Ser Tyr Gly 580 585 590 Asn Leu Ser Val Lys Ala Met Arg Asn Ile Leu Pro His Leu Gin Ala 595 600 605 Gly Lys Asp Tyr Ser Gin Ala Cys Glu Glu Ala Gly Tyr Lys His Ser 610 615 620 Arg Arg Ser Leu Thr Lys Glu Glu Leu Asn Gin Lys Val Tyr Lys Glu 625 630 635 640 Lys Leu Glu Leu Leu Pro Lys Asn Ser Leu His Asn Pro Val Val Glu 645 650 655 Lys Ile Leu Asn Gin Met Val Asn Val Ile Asn Ala Val Ile Glu Glu 660 665 670 Tyr Gly Lys Pro Asp Glu Ile Arg Ile Glu Leu Ala Arg Asp Leu Lys 675 680 685 Ile Gly Ala Ala Glu Arg Glu Asn Met Thr Arg Ser Ile Asn Gin Gly 690 695 700 Asn Ala Glu Asn Lys Arg Ile Arg Glu Ile Leu Glu Lys Glu Phe Ala 705 710 715 720 Leu Ser Tyr Leu Ser Arg Asn Asp Ile Ile Lys Tyr Lys Leu Tyr Glu 725 730 735 Glu Leu Lys Ser Asn Gly Phe Lys Thr Leu Tyr Ser Asp Thr Tyr Ile 740 745 750 Page 2827 of 3790 Page 2828 of 3790 Asp Lys Gly Asn Leu Gin Asp Asn Pro Val Ser Phe Phe Glu Ala 1149 1483 PRT Prevotella sp. Ser Lys Arg Arg Leu Val Gin Arg Asn Leu Gin Arg Arg Glu Arg Leu Page 2831 of 3790 Leu Gin Glu Pro Ala Asp Lys Ile Arg Gly Asn Phe Ile Arg Thr Ile 325 330 335 Glu Arg His Tyr Tyr Lys Ala Glu Leu Glu Ala Ile Leu Ala Glu Gin 340 345 350 Cys Lys Tyr His Ile Glu Leu Arg Asp Lys Glu Met Leu Glu Ala Cys 355 360 365 Ala Arg Glu Leu Tyr Leu Asn Asn Leu Pro His Gin Arg Ser Leu Met 370 375 380 Lys Lys Asp Met Thr Tyr Leu Leu Leu Tyr Asp Leu Ile Phe Tyr Gin 385 390 395 400 Arg Pro Leu Lys Ser Lys Lys Ala Leu Ile Ala Asn Cys Pro Tyr Glu 405 410 415 Tyr Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Arg Gin Asn 420 425 430 Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Phe Gin Glu Phe Arg Leu 435 440 445 Trp Gin Phe Val Leu Asn Leu Arg Leu Phe Asp Arg Val Glu Asp Lys 450 455 460 Glu Val Thr Ala Asn Tyr Leu Pro Thr Ala Asp Asp His Ala Arg Leu 465 470 475 480 Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Asn Gin Glu Thr Leu Leu 485 490 495 Lys Asp Tyr Phe Lys Leu Lys Lys Val Lys Ile Gly Asn Glu Lys Glu 500 505 510 Tyr Pro Ile Arg Trp Asn Tyr Ile Glu Asp Lys Glu Lys Lys Tyr Pro 515 520 525 Cys Asn Glu Thr Arg Tyr Glu Leu Leu Met Ala Leu Asp Arg Ala Gly 530 535 540 Ile Glu His Lys Trp Leu Asp Asp Asn Asn Leu Glu Tyr Arg Leu Trp 545 550 555 560 His Leu Leu Tyr Ser Val Glu Val Lys Ser Glu Ser Glu Thr Ala Leu 565 570 575 Page 2832 of 3790 Arg Lys Leu Lys Asn Asp Asp Ala Phe Val Asn Ser Phe Leu Lys Val 580 585 590 Lys Pro Phe Lys Lys Glu Tyr Gly Ala Tyr Ser Glu Lys Ala Ile Lys 595 600 605 Arg Leu Leu Ala Val Met Arg Lys Gly Phe Leu Trp Asn Glu Gin Asp 610 615 620 Ile Cys Asp Glu Thr Arg Lys Arg Ile Glu Ile Ile Ile Lys Gly Asp 625 630 635 640 Val Asp Glu Lys Val Lys Glu Arg Met Gly His Ala Ala Tyr Ser Phe 645 650 655 Asp Arg Val Ser Asp Phe Gin Gly Leu Pro Glu Trp Leu Ala Cys Tyr 660 665 670 Val Val Tyr Gly Arg His Ser Glu Ala Met Asp Ile Gin Arg Trp Asp 675 680 685 Ser Pro Glu Arg Leu Met Ala Tyr Ile Asn Asn Phe Lys Gin Tyr Ser 690 695 700 Leu Arg Asn Pro Ile Val Glu Gin Cys Ile Leu Glu Thr Leu Arg Thr 705 710 715 720 Val His Asp Ile Trp Lys Glu Thr Gly Gin Ile Asp Glu Ile His Val 725 730 735 Glu Leu Gly Arg Glu Met Lys Ser Thr Ser Glu Glu Arg Ala Arg Arg 740 745 750 Thr Gin Asn Val Leu Arg Asn Glu Asn Thr Asn Leu Arg Ile Lys Ser 755 760 765 Leu Leu Ile Glu Leu Lys Asn Asp Thr Asp Ile Cys Asn Val His Pro 770 775 780 Tyr Ser Pro Met Gin Gin Glu Ile Leu Arg Ile Tyr Glu Glu Gly Ala 785 790 795 800 Leu Gin Glu Leu Asn Arg Glu Asp Glu Asp Phe Glu Glu Ile Ser Lys 805 810 815 Ile Ser Gin Met Ser Gin Pro Ser Gly Lys Glu Leu Asn Arg Tyr Lys 820 825 830 Page 2833 of 3790 Ala Ser Arg Asn Ile Val Asn Tyr Leu Asn Asn Glu Ser Ala Asn Page 2835 of 3790 1150 593 PRT Prevotella sp. Trp Ala Val Val Asp Arg Asp Ala Lys Gly Asn Tyr Thr Leu Val Arg 20 25 30 Page 2836 of 3790 Arg Gly Asp Val Ile Phe Thr Glu Gly Val Asn Val Asp Gly Gin Pro 35 40 45 Val Pro Ser Lys Ala Ala Val Lys Ser Lys Tyr Lys Ser Leu Arg Val 50 55 60 Gin Tyr Ala Arg Arg Arg Leu Arg Lys Ile Asp Thr Leu Lys Val Leu 65 70 75 80 Val Ser Leu Asp Leu Cys Pro Tyr Leu Ser Asp Gin Gin Leu Ser Gin 85 90 95 Trp Lys Ala Lys Lys Thr Tyr Pro Leu Thr Asp Asp Phe Met Leu Trp 100 105 110 Gin Arg Ser Gly Ser Ala Glu Glu Asn Asn Pro Tyr Tyr Cys Arg Tyr 115 120 125 Arg Cys Leu Thr Gin Lys Leu Asp Leu Thr Asp Gin Ser Gin Arg Phe 130 135 140 Leu Leu Gly Arg Ala Phe Tyr His Leu Ala Gin Arg Arg Gly Phe Leu 145 150 155 160 Ser Asn Arg Leu Asp Thr Thr Ser Asp Ser Ala Glu Ser Gly Lys Val 165 170 175 Lys Ser Gly Ile Ala Gin Leu Ser Val Glu Met Glu Lys Ala Gly Cys 180 185 190 Thr Phe Leu Gly Glu Tyr Phe Tyr Gin Leu Tyr Lys Gin His Gly Asn 195 200 205 Thr Val Arg Leu Arg Ser Arg Tyr Thr Asp Arg Glu Glu His Tyr Ile 210 215 220 Lys Glu Phe Leu Ala Ile Cys Glu Lys Gin Glu Leu Asp Ala Gin Trp 225 230 235 240 Val Glu Lys Leu Gin Arg Ala Leu Tyr Phe Gin Arg Pro Leu Lys Ser 245 250 255 Gin Arg Lys Gly Val Gly Lys Cys Thr Phe Glu Pro Lys Lys Pro Arg 260 265 270 Cys Ala Glu Ser His Pro Asp Tyr Glu Ala Phe Arg Met Leu Cys Ile 275 280 285 Page 2837 of 3790 Leu Asn Asn Ile Lys Ile Lys Thr Pro Lys Asp Val Ser Leu Arg Pro 290 295 300 Leu Asn Ala Glu Glu Arg Glu Lys Val Trp Pro Leu Phe Phe Arg Lys 305 310 315 320 Ser Lys Pro Asn Phe Asp Phe Glu Asp Ile Ala Lys Ala Leu Ala Gly 325 330 335 Lys Asn Asn Tyr Ala Trp Tyr Lys Asp Ala Gly Glu Lys Pro Phe Arg 340 345 350 Phe Asn Tyr Arg Met His Gin Gly Val Ser Gly Cys Pro Val Thr Ala 355 360 365 Gin Leu Ile Asp Ile Phe Gly Ser Asp Trp Lys Ala Gly Ile Ala Glu 370 375 380 Thr Tyr Thr Ala Val Gly Lys Lys Asn Gly Thr Lys Thr Ile Asp Glu 385 390 395 400 Met Ala Asp Asp Val Trp Asn Val Leu Tyr Ser Phe Ser Ser Lys Asp 405 410 415 Lys Leu Lys Ala Phe Ala Thr Asp Lys Leu Gin Leu Asp Glu Ala Arg 420 425 430 Ala Thr Lys Phe Ala Asn Ala Lys Leu Pro His Gly Phe Ala Ala Leu 435 440 445 Ser Leu Lys Ala Ile Arg Asn Ile Leu Pro Phe Leu Arg Gin Gly Phe 450 455 460 Ile Tyr Ala His Ala Val Leu Leu Ala Lys Ile Pro Asp Ile Val Thr 465 470 475 480 Ala Ala Val Trp Asp Asp Ala Asp Lys Arg Glu Gin Ile Leu Ser Gly 485 490 495 Leu Leu Glu Val Ile Glu Asn Tyr Asn Pro Asp Asp Arg Gly Ile Glu 500 505 510 Gly Thr Ile Asp Phe Cys Ile Lys Ser His Leu Gin Asp Val Val Asp 515 520 525 Leu Arg Pro Gly Ala Ala Asp Ala Leu Tyr His Pro Ser Met Ile Glu 530 535 540 Page 2838 of 3790 Page 2839 of 3790 Leu Gly Arg Ala Leu Tyr His Ile Ala Gin His Arg Gly Phe Lys Ser 165 170 175 Ser Lys Gly Glu Thr Leu Ser Gin Gin Glu Thr Asn Ser Lys Pro Ser 180 185 190 Ser Thr Asp Glu Ile Pro Asp Val Ala Gly Ala Met Lys Ala Ser Glu 195 200 205 Glu Lys Leu Ser Lys Gly Leu Ser Thr Tyr Met Lys Glu His Asn Leu 210 215 220 Leu Thr Val Gly Ala Ala Phe Ala Gin Leu Glu Asp Glu Gly Val Arg 225 230 235 240 Val Arg Asn Asn Asn Asp Tyr Arg Ala Ile Arg Ser Gin Phe Gin His 245 250 255 Glu Ile Glu Thr Ile Phe Lys Phe Gin Gin Gly Leu Ser Val Glu Ser 260 265 270 Glu Leu Tyr Glu Arg Leu Ile Ser Glu Lys Lys Asn Val Gly Thr Ile 275 280 285 Phe Tyr Lys Arg Pro Leu Arg Ser Gin Arg Gly Asn Val Gly Lys Cys 290 295 300 Thr Leu Glu Arg Ser Lys Pro Arg Cys Ala Ile Gly His Pro Leu Phe 305 310 315 320 Glu Lys Phe Arg Ala Trp Thr Leu Ile Asn Asn Ile Lys Val Arg Met 325 330 335 Ser Val Asp Thr Leu Asp Glu Gin Leu Pro Met Lys Leu Arg Leu Asp 340 345 350 Leu Tyr Asn Glu Cys Phe Leu Ala Phe Val Arg Thr Glu Phe Lys Phe 355 360 365 Glu Asp Ile Arg Lys Tyr Leu Glu Lys Arg Leu Gly Ile His Phe Ser 370 375 380 Tyr Asn Asp Lys Thr Ile Asn Tyr Lys Asp Ser Thr Ser Val Ala Gly 385 390 395 400 Cys Pro Ile Thr Ala Arg Phe Arg Lys Met Leu Gly Glu Glu Trp Glu Page 2841 of 3790 Lys Leu Tyr His Pro Ser Gin Ile Thr Ile Tyr Arg Pro Val Ser Val 660 665 670 Gly Lys Asp Arg Ser Val Leu Arg Leu Gly Asn Pro Asp Ile Gly Ala 675 680 685 Ile Lys Asn Pro Thr Val Leu Arg Val Leu Asn Thr Leu Arg Arg Arg 690 695 700 Val Asn Gin Leu Leu Asp Asp Gly Val Ile Ser Pro Asp Glu Thr Arg 705 710 715 720 Val Val Val Glu Thr Ala Arg Glu Leu Asn Asp Ala Asn Arg Lys Trp 725 730 735 Ala Leu Asp Thr Tyr Asn Arg Ile Arg His Asp Glu Asn Glu Lys Ile 740 745 750 Lys Lys Ile Leu Glu Glu Phe Tyr Pro Lys Arg Asp Gly Ile Ser Thr 755 760 765 Asp Asp Ile Asp Lys Ala Arg Tyr Val Ile Asp Gin Arg Glu Val Asp 770 775 780 Tyr Phe Thr Gly Ser Lys Thr Tyr Asn Lys Asp Ile Lys Lys Tyr Lys 785 790 795 800 Phe Trp Leu Glu Gin Gly Gly Gin Cys Met Tyr Thr Gly Arg Thr Ile 805 810 815 Asn Leu Ser Asn Leu Phe Asp Pro Asn Ala Phe Asp Ile Glu His Thr 820 825 830 Ile Pro Glu Ser Leu Ser Phe Asp Ser Ser Asp Met Asn Leu Thr Leu 835 840 845 Cys Asp Ala His Tyr Asn Arg Phe Ile Lys Lys Asn His Ile Pro Thr 850 855 860 Asp Met Pro Asn Tyr Asp Lys Ala Ile Thr Ile Asp Gly Lys Glu Tyr 865 870 875 880 Pro Ala Ile Thr Ser Gin Leu Gin Arg Trp Val Glu Arg Val Glu Arg 885 890 895 Leu Asn Arg Asn Val Glu Tyr Trp Lys Gly Gin Ala Arg Arg Ala Gin 900 905 910 Page 2842 of 3790 Page 2843 of 3790 Thr Val Asp Tyr Gin Asn Leu Pro Glu Ser Ile Arg Ser Ser Val 1385 Page 2844 of 3790 1390 1395 Lys Ser Leu Asn Phe Leu Ile Met Gly Glu Asn Arg Asp Phe Val 1400 1405 1410 Ile Lys Asn Gly Lys Ile Ile Phe Asn His Arg 1415 1420 Lys Thr Ala Ile Ala Glu Pro Ile Phe Met Asn Lys Glu Lys Gly Ile 20 25 30 Arg Ile Asn Lys Val Arg Tyr Tyr Val Lys Ala Gin Glu Arg Leu Lys 35 40 45 Ile Arg Gin Gin Arg Asp Leu Ser Ser Lys Glu Tyr Lys Gin Phe Phe 50 55 60 Cys Val Glu Asn Glu Ser Asn Tyr Leu Leu Ala Ile Tyr Glu Gly Glu 65 70 75 80 Leu Lys Gly Lys Lys Glu Arg Asp Phe Cys Val Val Asn Asn Leu Asp 85 90 95 Ser Ala Ala Cys Leu Lys Arg Ser Asn Lys Gly Lys Ala Ala Pro Leu 100 105 110 Val Pro Glu Arg Ser Glu Glu Arg Asn Leu Pro Leu Leu Ala Val Leu 115 120 125 Lys Arg Gly Thr Gin Val Leu Phe Tyr Glu Asn Ser Pro Glu Glu Ile 130 135 140 Leu Phe Asp Asn Pro Gin Asp Leu Val Arg Arg Leu Tyr Lys Val Thr 145 150 155 160 Gly Ile Asn Thr Lys Lys Asp Val Lys Asn Gly Lys Thr Tyr Leu Tyr 165 170 175 Gly Asn Ile Glu Leu Arg Phe His Gin Asn Ala Gin Lys Lys Asp Asp Ile His 130 Glu Lys Leu Asp Leu 135 Ser Asp Val Thr Asp Arg 140 Tyr Ile Leu Gly Arg Ala Phe Tyr His Ile Ile Gin Arg Arg Gly Phe Leu Ser Asn Page 2847 of 3790 Trp His Ala Leu Tyr Phe Tyr Ser Asp Lys Asp Lys Leu Ala Glu Phe 405 410 415 Ala Ile Asn Arg Leu Gin Leu Ser Glu Asp Glu Ala Lys Ile Phe Ser 420 425 430 Glu Ile Ser Leu Pro Ala Asp Tyr Ala Ser Leu Ser Leu Lys Ala Ile 435 440 445 Cys Lys Ile Leu Pro Tyr Leu Arg Arg Gly Leu Ile Tyr Ser His Ala 450 455 460 Val Phe Leu Gly Asn Leu Cys Glu Val Met Pro Lys Tyr Glu Trp Ser 465 470 475 480 Ile Lys Glu Met Arg Glu Thr Ile Ile Asp Asn Ile Ile Met Glu Met 485 490 495 Asp Lys Cys Asp Thr Lys Asp Lys Arg Thr Phe Glu Val Cys Ile Lys 500 505 510 Asp Tyr Leu Lys Gly Gin Tyr Asn Val Ser Asp Asn Ser Leu Lys Lys 515 520 525 Leu Tyr His Pro Ser Met Ile Glu Thr Tyr Pro Arg Val Gin Tyr Thr 530 535 540 Asn Glu His Gly Val Tyr Gin Leu Gly Ser Pro Arg Ile Asp Ser Val 545 550 555 560 Arg Asn Pro Met Ala Met Arg Ser Met Phe Arg Leu Arg Lys Leu Val 565 570 575 Asn Arg Leu Leu Val Glu Gly Lys Ile Asp Gin Asn Thr Glu Val His 580 585 590 Ile Glu Phe Ala Arg Glu Leu Asn Asp Ala Asn Lys Arg Asn Ala Ile 595 600 605 Ala Leu Phe Val Lys Glu Asn Gin Ser Ala Asn Asp Glu Ala Arg Lys 610 615 620 Gin Ile Ile Thr Leu Phe Lys Lys Glu Thr Gly Thr Asp Ile Glu Pro 625 630 635 640 Thr Asp Lys Asp Ile Leu Lys Tyr Val Leu Trp Glu Glu Gin Asn His 645 650 655 Page 2848 of 3790 Ile Cys Leu Tyr Thr Gly Lys Gin Ile Arg Ile Ser Asp Phe Ile Gly 660 665 670 Ala Asn Pro Lys Phe Asp Ile Glu His Thr Ile Pro Arg Ser Val Gly 675 680 685 Gly Asp Ser Thr Lys Met Asn Leu Thr Leu Cys Asp Ser Arg Phe Asn 690 695 700 Arg Glu Val Lys Lys Thr Lys Leu Pro Val Glu Leu Pro Asn His Asp 705 710 715 720 Glu Ile Met Glu Arg Ile Lys Glu Trp Lys Lys Asn Tyr Glu Leu Leu 725 730 735 Asp Ile Gin Ile Arg Lys Asn Lys Lys Leu Ser Lys Gly Ala Thr Thr 740 745 750 Lys Glu Gin Lys Asp Thr Ile Ile Arg Lys Arg His Leu Leu Glu Leu 755 760 765 Arg Arg Asp Tyr Trp Arg Gly Lys Tyr Glu Arg Phe Thr Met Glu Ser 770 775 780 Val Pro Glu Gly Phe Ser Arg Arg Gin Gly Thr Asp Ile Ser Val Ile 785 790 795 800 Ser Lys Tyr Ala Arg Leu Tyr Leu Lys Ser Leu Phe Asn Arg Val Tyr 805 810 815 Thr Val Lys Gly Ile Ala Thr Ser Asp Phe Arg Lys Ile Trp Gly Ile 820 825 830 Gin Asp Ile Tyr Ser Lys Lys Glu Arg Ile Asn His Val His His Cys 835 840 845 Ile Asp Ala Ile Val Ile Ala Cys Ile Gly Leu Asp Glu Tyr Asn Lys 850 855 860 Leu Gly Ala Tyr Tyr His Asp Glu Glu Asn Asn Lys Trp Tyr Gly Met 865 870 875 880 Ser Lys Ala Ser Phe Lys Lys Pro Trp Ala Thr Phe Val Glu Asp Ile 885 890 895 Lys Lys Ile Gin Asp Glu Ile Leu Val Tyr His Tyr Thr Pro Asp Asn 900 905 910 Page 2849 of 3790 Arg Met Lys Gly Arg Asn Gly Glu Tyr Ala Tyr Ala Thr Val Lys Page 2850 of 3790 1145 1150 1155 1205 1210 1215 1154 1487 PRT Prevotella timonensis Asp Phe Ala Lys His Gin Pro Gin Leu Ile Ala Asn Gly Lys Lys Val Page 2852 of 3790 Tyr Gin Arg Pro Leu Lys Ser Lys Lys Ser Leu Ile Ala Asn Cys Lys 405 410 415 Tyr Glu Ser Tyr Glu Tyr Val Asp Lys Glu Thr Gly Glu Ile Lys Glu 420 425 430 Met Pro Ile Lys Cys Ile Ala Lys Ser Asn Pro Tyr Tyr Gin Glu Phe 435 440 445 Arg Leu Trp Gin Phe Ile His Asn Leu Arg Leu Ser Asp Val Val Thr 450 455 460 Arg Glu Asp Val Thr Ala Gin Tyr Leu Ser Thr Pro Gin Asp Tyr Cys 465 470 475 480 Asn Leu Phe Thr Tyr Leu Asn Asp Arg Lys Glu Ile Lys Gin Asp Ile 485 490 495 Leu Leu Lys Asp Phe Phe Lys Ile Lys Lys Val Gin Ile Asp Lys Glu 500 505 510 Lys Val Phe Pro Ile Glu Trp Asn Tyr Ile Lys Asp Ala Thr Lys Ser 515 520 525 Tyr Pro Cys Asn Glu Thr Arg Tyr Glu Leu Leu Ser Ala Leu Lys Arg 530 535 540 Ala Gly Met Asp Lys Gin Trp Leu Asp Asp Thr Pro Asn Met Gin Tyr 545 550 555 560 Arg Leu Trp His Leu Leu Tyr Ser Val Glu Glu Lys Glu Glu Ser Ala 565 570 575 Lys Ala Leu Arg Lys Leu Tyr Asp Asp Asp Lys Phe Val Thr Ser Phe 580 585 590 Leu Lys Ile Lys Pro Phe Asn Lys Cys Tyr Gly Ala Tyr Ser Glu Lys 595 600 605 Ala Ile Lys Arg Leu Leu Thr Leu Met Arg Met Gly Lys Ala Trp Asn 610 615 620 Glu Gin Ala Ile Asp Ala Lys Thr Leu Lys Cys Ile Gin Gin Ile Ile 625 630 635 640 Thr Asp Asn Val Asp Ser Lys Leu Lys Glu Lys Ile Asp Asp Ser Arg 645 650 655 Page 2853 of 3790 Tyr Val Leu His His Val Ser Asp Phe Gin Gly Leu Pro Thr Tyr Leu 660 665 670 Ala Ser Tyr Val Ile Tyr Gly Arg His Ser Glu Val Thr Asp Ile Gin 675 680 685 Cys Trp Asp Ser Pro Glu Asp Leu Leu Lys Phe Ile Arg Asp Phe Lys 690 695 700 Gin His Ser Leu Arg Asn Pro Ile Val Glu Gin Val Ile Leu Glu Thr 705 710 715 720 Leu Arg Val Val Tyr Asp Ile Trp Lys Ala Glu Lys His Ile Asp Glu 725 730 735 Ile His Val Glu Val Ala Arg Glu Met Lys Leu Thr Ala Gin Gin Arg 740 745 750 Asn Glu Ala Asn Leu Arg Asn Leu Asn Asn Glu Ala Thr Asn Leu Arg 755 760 765 Ile Lys Tyr Leu Leu Glu Glu Leu Lys Asn Asp Thr Phe Ile Lys Asp 770 775 780 Val Arg Pro Leu Ser Pro Ile His Gin Glu Lys Met Arg Ile Tyr Glu 785 790 795 800 Gin Ala Val Leu Gly Asn Leu Asn Lys Gin Asp Lys Asp Tyr Asp Asp 805 810 815 Ile Ile Lys Ile Ser Lys Lys Glu His Pro Thr Asn Ala Glu Leu Ile 820 825 830 Arg Tyr Lys Leu Trp Leu Glu Gin Arg Tyr Cys Ser Pro Tyr Thr Gly 835 840 845 Lys Ala Ile Ser Leu Ser Lys Leu Phe Thr Thr Ala Tyr Glu Ile Glu 850 855 860 His Ile Ile Pro Gin Ser Arg Tyr Phe Asp Asn Ser Phe Asn Asn Lys 865 870 875 880 Val Ile Cys Glu Ala Glu Val Asn Lys Ala Lys Gly Asn Met Leu Gly 885 890 895 Tyr Glu Phe Ile Lys Lys Gin Gly Gly Gin Lys Ile Tyr Cys Thr Gin 900 905 910 Page 2854 of 3790 Arg Tyr Asp Lys Asn Gly Lys Lys Ile Ile Phe Ser Gin Lys Gly 1155 770 PRT Pseudoramibacter alactolyticus 1155 Met Ala Lys Gly Tyr Phe Ala Ser Asp Glu Glu Ile Asp Phe Ser Gly 15 10 15 Val Asp Asp Gly Phe Lys Asn Thr Leu Ser Ser His Gin Lys 20 25 30 Phe Lys Glu Ile Phe Asp Val 35 Glu Val Leu Asn Asp 40 Trp Gin Lys 45 Ser Met Ser Glu Lys Ile Ile Phe Trp Ala Thr Val Tyr Gly Asp Ser Lys Lys Phe 50 55 60 Leu Lys 65 Glu Arg Leu Glu Asp Ala 70 Tyr Gly Asn Glu 75 Leu Asp Gin Lys Gin Ile Lys Arg Ile Leu Gly Leu Arg Phe 90 Lys Asp Trp Gly Arg Leu 95 Ser Glu Ala Phe Leu Asn Leu Glu Gly Lys Asn Ser Lys Thr Asn Gin 100 105 110 Page 2857 of 3790 Ser Gin Thr Ile Ile Glu Ala Leu Trp Asn Gly Asp Gly Thr Asn Asn 115 120 125 Phe Asn Leu Met Glu Leu Leu Ser Ser Gin Phe Thr Tyr Arg Asp Thr 130 135 140 Leu Lys Lys Arg Ala Leu Lys Gly Glu Lys Thr Leu Thr Asn Ile Thr 145 150 155 160 Tyr Glu Asp Leu Ser Asp Leu Tyr Leu Ser Pro Ser Val Arg Arg Met 165 170 175 Val Trp Gin Thr Ile Leu Ile Val Lys Glu Leu Arg Gin Val Leu Gly 180 185 190 Ala Gly Pro Ala Lys Ile Phe Ile Glu Met Ala Arg Asp Val Thr Leu 195 200 205 Lys Ala Gly Thr Arg Thr Thr Ser Arg Arg Gin Gin Leu Leu Asp Leu 210 215 220 Tyr Lys Asn Val Gin Thr Glu Ser Arg Asn Trp Val Glu Glu Ile Glu 225 230 235 240 Thr Gin Glu Glu Ser Arg Phe Arg Ser Lys Lys Ile Phe Leu Tyr Tyr 245 250 255 Thr Gin Met Gly Gin Cys Met Tyr Thr Gly Glu Pro Ile Val Phe Lys 260 265 270 Asp Leu Phe Asn Arg Asn Leu Tyr Asp Ile Asp His Ile Tyr Pro Arg 275 280 285 His Phe Val Lys Asp Asp Ser Leu Ile Asn Asn Leu Val Leu Val Lys 290 295 300 Lys Gin Ala Asn Ser His Lys Ser Asp Thr Phe Pro Ile Glu Asn Ser 305 310 315 320 Ile Gin Gin Ala Arg Arg Asp Phe Trp Lys Trp Leu Ser Glu Lys Gly 325 330 335 Leu Ile Ser Arg Glu Lys Phe Asn Arg Leu Thr Arg Arg Thr Ser Phe 340 345 350 Ser Asp Glu Glu Leu Ala Gly Phe Ile Ser Arg Gin Ile Val Glu Thr 355 360 365 Page 2858 of 3790 Arg Gin Gly Thr Lys Ala Val Ala Gin Ile Phe Glu Asn Ala Leu Pro 370 375 380 Asp Ser Glu Val Val Tyr Val Lys Ala Gly Asn Val Ser Asp Phe Arg 385 390 395 400 His His Phe Asn Leu Leu Lys Cys Arg Glu Ile Asn Asp Leu His His 405 410 415 Ala Gin Asp Ala Tyr Leu Asn Val Val Val Gly Asn Val Tyr His Thr 420 425 430 Lys Phe Thr Lys Asn Pro Ile Asn Phe Ile Lys Gly Tyr Arg Lys Asp 435 440 445 Arg Lys Ala Tyr Ala Tyr His Met Asp Gin Ile Phe Asp His Pro Val 450 455 460 Lys Arg Asn Asp Ile Ile Ala Trp Gin Thr Asp Lys Asn Gin Ser Ile 465 470 475 480 Ala Thr Val Lys Lys Val Met Ala Lys Gly Thr Pro Leu Val Thr Arg 485 490 495 Met Ser Tyr Glu Glu His Gly Glu Leu Ser Asn Gin Asn Ile Cys Ser 500 505 510 Ala Lys Ala Ala Gin Lys Ala Glu Gly Lys Gly Tyr Leu Pro Ile Lys 515 520 525 Asn Ser Glu Arg Leu Ser Asn Thr Gin Arg Tyr Gly Gly Tyr Asn Lys 530 535 540 Tyr Ala Gly Ser Tyr Phe Phe Leu Val Glu His Thr Leu Lys Lys Asn 545 550 555 560 Arg Val Arg Thr Ile Glu Thr Met Pro Leu Phe Leu Arg Asp Thr Ile 565 570 575 Lys Thr Ser Lys Asp Leu Leu Lys Tyr Cys Cys Glu Ser Leu Lys Leu 580 585 590 Glu Ala Pro Ser Ile Arg Val Met Lys Ile Lys Met Gly Ser Leu Leu 595 600 605 Ser Val Asn Gly Ala Phe Val Tyr Leu Thr Gly Arg Ser Gly Lys Lys 610 615 620 Page 2859 of 3790 Page 2860 of 3790 Page 2861 of 3790 Arg Gly Thr Pro Arg Thr Arg Ser Pro Thr Arg Ile Arg Met Glu Gly 180 185 190 Glu Gly Ala Lys Ala Leu Tyr Ala Phe Tyr Pro Thr Arg Glu Met Val 195 200 205 Arg Ala Glu Phe Glu Arg Leu Trp Thr Ala Gin Ser Arg Phe Ala Pro 210 215 220 Asp Leu Leu Thr Pro Glu Arg His Glu Glu Ile Ala Gly Ile Leu Phe 225 230 235 240 Arg Gin Arg Asp Leu Ala Pro Pro Lys Ile Gly Cys Cys Thr Phe Glu 245 250 255 Pro Ser Glu Arg Arg Leu Pro Arg Ala Leu Pro Ser Val Glu Ala Arg 260 265 270 Gly Ile Tyr Glu Arg Leu Ala His Leu Arg Ile Thr Thr Gly Pro Val 275 280 285 Ser Asp Arg Gly Leu Thr Arg Pro Glu Arg Asp Val Leu Ala Ser Ala 290 295 300 Leu Leu Ala Gly Lys Ser Leu Thr Phe Lys Ala Val Arg Lys Thr Leu 305 310 315 320 Lys Ile Leu Pro His Ala Leu Val Asn Phe Glu Glu Ala Gly Glu Lys 325 330 335 Gly Leu Asp Gly Ala Leu Thr Ala Lys Leu Leu Ser Lys Pro Asp His 340 345 350 Tyr Gly Ala Ala Trp His Gly Leu Ser Phe Ala Glu Lys Asp Thr Phe 355 360 365 Val Gly Lys Leu Leu Asp Glu Ala Asp Glu Glu Arg Leu Ile Arg Arg 370 375 380 Leu Val Thr Glu Asn Arg Leu Ser Glu Asp Ala Ala Arg Arg Cys Ala 385 390 395 400 Ser Ile Pro Leu Ala Asp Gly Tyr Gly Arg Leu Gly Arg Thr Ala Asn 405 410 415 Thr Glu Ile Leu Ala Ala Leu Val Glu Glu Thr Asp Glu Thr Gly Thr Page 2863 of 3790 Pro Ala Ala Leu Glu Arg Phe Glu Arg Glu Gly Gly Phe Leu Gly Arg 675 680 685 Gin Leu Asn Glu Thr Lys Tyr Leu Ser Arg Leu Ala Lys Ile Tyr Leu 690 695 700 Gly Lys Ile Cys Asp Pro Asp Arg Val Tyr Val Thr Pro Gly Thr Leu 705 710 715 720 Thr Gly Leu Leu Arg Ala Arg Trp Gly Leu Asn Ser Ile Leu Ser Asp 725 730 735 Ser Asn Phe Lys Asn Arg Ser Asp His Arg His His Ala Val Asp Ala 740 745 750 Val Val Ile Gly Val Leu Thr Arg Gly Met Ile Gin Arg Ile Ala His 755 760 765 Asp Ala Ala Arg Ala Glu Asp Gin Asp Leu Asp Arg Val Phe Arg Asp 770 775 780 Val Pro Val Pro Phe Glu Asp Phe Arg Asp His Val Arg Glu Arg Val 785 790 795 800 Ser Thr Ile Thr Val Ala Val Lys Pro Glu His Gly Lys Gly Gly Ala 805 810 815 Leu His Glu Asp Thr Ser Tyr Gly Leu Val Pro Asp Thr Asp Pro Asn 820 825 830 Ala Ala Leu Gly Asn Leu Val Val Arg Lys Pro Ile Arg Ser Leu Thr 835 840 845 Ala Gly Glu Val Asp Arg Val Arg Asp Arg Ala Leu Arg Ala Arg Leu 850 855 860 Gly Ala Leu Ala Ala Pro Phe Arg Asp Glu Ser Gly Arg Val Arg Asp 865 870 875 880 Ala Lys Gly Leu Ala Gin Ala Leu Glu Ala Phe Gly Ala Glu Asn Gly 885 890 895 Ile Arg Arg Val Arg Ile Leu Lys Pro Asp Ala Ser Val Val Thr Ile 900 905 910 Ala Asp Arg Arg Thr Gly Val Pro Tyr Arg Ala Val Ala Pro Gly Glu 915 920 925 Page 2864 of 3790 1055 1158 1405 PRT Riemerella anatipestifer 1158 Met Lys Thr Ile Leu Gly Leu Asp Leu Gly Thr Asn Ser Ile Gly Trp 15 10 15 Ala Leu Val Lys Glu Ala Glu Asn Ser Asn Glu Lys Ser Glu Ile Ile 20 25 30 Lys Leu Gly Val Arg Val Asn Pro Leu Thr Val Asp Glu Lys Thr Asn 35 40 45 Phe Glu Ala Gly Arg Pro Leu Ser Thr Asn Ala Asp Arg Thr Ala Lys 50 55 60 Arg Ser Ala Arg Arg Asn Leu Gin Arg Tyr Lys Leu Arg Arg Lys Asn 65 70 75 80 Page 2865 of 3790 Leu Ile Asp Leu Leu Ile Lys Asn Gin Leu Ile Asp Lys Asp Thr Pro 85 90 95 Leu Thr Glu Ile Gly Lys Asn Thr Thr His Gin Thr Leu Glu Leu Arg 100 105 110 Ala Lys Ala Ala Arg Glu Arg Ile Glu Leu Glu Asp Leu Ala Arg Val 115 120 125 Phe Leu Ala Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Val 130 135 140 Asn Asn Glu Glu Glu Gly Gin Ala Val Asp Gly Met Ala Val Ala Lys 145 150 155 160 Lys Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gin Tyr Ala Tyr Glu Leu 165 170 175 Leu Ser Lys Gly Lys Lys Tyr Val Pro Asp Phe Tyr Arg Ser Asp Leu 180 185 190 Gin Ala Glu Phe Asn Ala Ile Trp Glu Tyr Gin Lys Gin Phe Tyr Ala 195 200 205 Asp Ile Leu Asp Asp Glu Leu Tyr Asn Ala Leu Lys Gly Gin Gly Gin 210 215 220 Gin Asn Ser Arg Lys Arg Phe Leu Ala Ile Lys Gly Val Tyr Thr Ala 225 230 235 240 Glu Asn Lys Gly Lys Arg Asp Asp Val Lys Leu Arg His Tyr Lys Trp 245 250 255 Arg Ser Glu Ala Ile Ser Lys Lys Ile Asn Ile Glu Glu Val Ala Tyr 260 265 270 Val Leu Val Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Glu Thr 290 295 300 Val Gly Glu Asn Leu Trp Lys Gin Ile Gin Lys Asn Pro His Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Page 2866 of 3790 Gin Ile Trp Glu Thr Gin Ala Gin Phe His Pro Gin Leu Thr Leu Ala 340 345 350 Leu Lys Glu Gin Ile Arg Asp Val Ile Ile Phe Tyr Gin Arg Lys Leu 355 360 365 Lys Ser Gin Lys Gly Leu Leu Ser Phe Cys Gin Phe Glu Ser Trp Glu 370 375 380 Ile Glu Arg Lys Asp Glu Asn Gly Asn Val Ile Leu Asn Lys Thr Thr 385 390 395 400 Gin Leu Pro Lys Arg Gin Thr Val Gly Arg Arg Val Ala Pro Lys Ser 405 410 415 Ser Pro Leu Phe Gin Glu Phe Lys Ile Trp Gin Asn Ile Asn Asn Leu 420 425 430 Glu Val Thr Lys Ile Ser Glu Gly Ala Ser Lys Asn Lys Lys Glu Thr 435 440 445 Glu Thr Leu Ser Asp Asp Glu Arg Lys Leu Leu Phe Glu Glu Leu Asn 450 455 460 Leu Arg Gly Asn Leu Ser Gin Lys Glu Val Leu Gin Ile Leu Gly Leu 465 470 475 480 Lys Asp Lys Glu Tyr Lys Thr Asn Phe Ser Glu Gly Leu Glu Gly Asn 485 490 495 Arg Thr Asn Ala Ala Leu Phe Asn Ile Tyr Gin Gin Ile Ala Glu Asn 500 505 510 Glu Gly Tyr Gly Phe Asp Trp Ser Lys Lys Ser Ala Gin Glu Ile Lys 515 520 525 Glu Glu Leu Lys Ala Val Phe Pro Gin Ile Gly Ile Gin Ala Asp Ile 530 535 540 Leu Asp Phe Asn Ala Asn Leu Asp Gly Lys Glu Phe Glu Asn Gin Ala 545 550 555 560 Ser Tyr Gin Leu Trp His Leu Leu Tyr Ser Ala Glu Glu Asp Asp Lys 565 570 575 Ile Asn Glu Glu Asp Gin Ile Ile Tyr Gly Asn Ser Ala Val Ser Leu Page 2868 of 3790 Page 2869 of 3790 Page 2870 of 3790 1400 1405 1159 1145 PRT Riemerella anatipestifer 1159 Page 2871 of 3790 Phe Leu Ala Ile Asn Lys Lys Arg Gly Tyr Arg Ser Ser Arg Lys Val 130 135 140 Asn Asn Glu Glu Glu Gly Gin Val Val Asp Gly Met Ala Val Ala Lys 145 150 155 160 Lys Leu Tyr Asp Glu Asn Leu Thr Pro Gly Gin Tyr Ala Tyr Glu Leu 165 170 175 Leu Ser Lys Gly Lys Lys Tyr Val Pro Asp Phe Tyr Arg Ser Asp Leu 180 185 190 Gin Ala Glu Phe Asp Ser Ile Trp Glu Tyr Gin Lys Gin Phe Tyr Ala 195 200 205 Asp Ile Leu Asp Asp Glu Leu Tyr Asn Ala Leu Lys Gly Gin Gly Gin 210 215 220 Gin Asn Ser Arg Lys Arg Phe Leu Ala Ile Lys Gly Val Tyr Thr Ala 225 230 235 240 Glu Asn Lys Gly Lys Arg Asp Glu Val Lys Leu Gin His Tyr Lys Trp 245 250 255 Arg Ser Glu Ala Ile Thr Gin Lys Leu Ser Ile Glu Glu Val Ala Tyr 260 265 270 Val Leu Val Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Glu Thr 290 295 300 Val Gly Glu Asn Leu Trp Lys Gin Ile Gin Lys Asn Pro His Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Gin Ile Trp Glu Thr Gin Ala Gin Phe His Pro Gin Leu Thr Leu Ala 340 345 350 Leu Lys Glu Gin Ile Arg Asp Val Val Ile Phe Tyr Gin Arg Lys Leu 355 360 365 Lys Ser Gin Lys Gly Leu Leu Ser Phe Cys Gin Phe Glu Ser Trp Glu Page 2873 of 3790 Ala Met Arg Lys Ile Ile Pro Tyr Leu Ile Asp Gly Asn Asp Tyr Ser 625 630 635 640 Glu Ala Cys Ala Leu Ala Gly Tyr Asn His Ser Asn Ser Leu Thr Lys 645 650 655 Glu Glu Asn Asp Asn Arg Glu Arg Leu Asn Lys Leu Glu Leu Leu Pro 660 665 670 Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gin Met 675 680 685 Val Asn Val Val Asn Gin Val Ile Glu Thr Tyr Gly Lys Pro Asp Glu 690 695 700 Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser Ala Glu Glu Arg 705 710 715 720 Ala Glu Met Thr Lys Gly Ile Asn Glu Ala Thr Arg Arg Asn Glu Asp 725 730 735 Ile Lys Lys Leu Ile Thr Lys Asn Phe Gly Ile Pro Asn Pro Thr Lys 740 745 750 Asn Asp Val Val Arg Tyr Arg Leu Trp Glu Glu Leu Ala Pro Leu Ala 755 760 765 Tyr Lys Asp Val Phe Thr Gly Arg Gin Ile Lys Lys Glu Asp Leu Phe 770 775 780 Ser Ser Lys Ile Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu Phe 785 790 795 800 Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Arg Glu Thr Asn Leu 805 810 815 Lys Lys Ala Asp Arg Thr Ala Tyr Gly Phe Ile Glu Ser Asp Tyr Asn 820 825 830 Ala Thr Leu Asp Asp Tyr Ile Gin Arg Val Glu Thr Leu Tyr Asn Asn 835 840 845 Ala Lys Gly Thr Ile Ser Lys Gly Lys Arg Asn Lys Leu Leu Met Ala 850 855 860 Gin Lys Asn Leu Pro Asp Gly Phe Ile Glu Arg Asp Leu Arg Asn Ser 865 870 875 880 Page 2874 of 3790 Val Leu Arg His Leu Ala Gin Phe Asp Asn Asn Pro Ala Val Ala 1115 1120 1125 Page 2875 of 3790 Phe Asp Thr Lys Thr Leu Lys Lys Cys His Tyr Leu Lys Met Val 1130 1135 1140 Asn Leu 1145 1160 1400 PRT Riemerella anatipestifer Page 2876 of 3790 Gin Ala Glu Phe Asp Ser Ile Trp Glu Tyr Gin Lys Gin Phe Tyr Ala 195 200 205 Asp Ile Leu Asp Asp Glu Leu Tyr Asn Ala Leu Lys Gly Gin Gly Gin 210 215 220 Gin Asn Ser Arg Lys Arg Phe Leu Ala Ile Lys Gly Val Tyr Thr Ala 225 230 235 240 Glu Asn Lys Gly Lys Arg Asp Glu Val Lys Leu Gin His Tyr Lys Trp 245 250 255 Arg Ser Glu Ala Ile Thr Gin Lys Leu Ser Ile Glu Glu Val Ala Tyr 260 265 270 Val Leu Val Glu Ile Asn Asn Asp Leu Asn Lys Ser Ser Gly Tyr Leu 275 280 285 Gly Ala Ile Ser Asp Arg Ser Lys Glu Leu Tyr Phe Asn Lys Glu Thr 290 295 300 Val Gly Glu Asn Leu Trp Lys Gin Ile Gin Lys Asn Pro His Thr Ser 305 310 315 320 Leu Lys Asn Gin Val Phe Tyr Arg Gin Asp Tyr Leu Asp Glu Phe Glu 325 330 335 Gin Ile Trp Glu Thr Gin Ala Gin Phe His Pro Gin Leu Thr Leu Ala 340 345 350 Leu Lys Glu Gin Ile Arg Asp Val Val Ile Phe Tyr Gin Arg Lys Leu 355 360 365 Lys Ser Gin Lys Gly Leu Leu Ser Phe Cys Gin Phe Glu Ser Trp Glu 370 375 380 Ile Glu Arg Lys Asp Glu Asn Gly Asn Val Ile Leu Asn Lys Thr Thr 385 390 395 400 Gin Leu Pro Lys Arg Gin Thr Val Gly Arg Arg Val Ala Pro Lys Ser 405 410 415 Ser Pro Leu Phe Gin Glu Phe Lys Ile Trp Gin Asn Ile Asn Asn Leu 420 425 430 Glu Ile Ala Lys Ile Ser Asp Gly Asn Ser Lys Asn Lys Lys Glu Thr Page 2877 of 3790 435 440 445 Glu Ala Leu Ser Asp Asp Glu Arg Lys Leu Leu Phe Glu Glu Leu Asn 450 455 460 Leu Arg Gly Asn Leu Ser Gin Lys Glu Val Leu Gin Ile Leu Gly Leu 465 470 475 480 Lys Asp Lys Glu Tyr Lys Thr Asn Phe Pro Glu Gly Leu Glu Gly Asn 485 490 495 Arg Thr Asn Ala Ala Leu Phe Asn Ile Tyr Gin Gin Ile Ala Glu Asn 500 505 510 Glu Gly Tyr Gly Asp Trp Thr Lys Lys Ser Ala Gin Glu Ile Lys Glu 515 520 525 Glu Leu Lys Ala Val Phe Pro Gin Ile Gly Ile Gin Ala Asp Ile Leu 530 535 540 Asp Phe Asn Ala Glu Leu Asp Gly Lys Glu Phe Glu Asn Gin Ala Ser 545 550 555 560 Tyr Gin Leu Trp His Leu Leu Tyr Ser Ala Glu Glu Asp Asp Lys Ile 565 570 575 Asn Glu Glu Asp Gin Ile Ile Tyr Gly Asn Ser Ala Val Ser Leu Lys 580 585 590 Lys Lys Leu Cys Glu Lys Phe Gly Phe Thr Pro Glu Tyr Ala Lys Trp 595 600 605 Ile Ala Asn Val Ser Leu Gin Asp Asp Tyr Gly Asn Leu Ser Thr Lys 610 615 620 Ala Met Arg Lys Ile Ile Pro Tyr Leu Ile Asp Gly Asn Asp Tyr Ser 625 630 635 640 Glu Ala Cys Ala Leu Ala Gly Tyr Asn His Ser Asn Ser Leu Thr Lys 645 650 655 Glu Glu Asn Asp Asn Arg Glu Arg Leu Asn Lys Leu Glu Leu Leu Pro 660 665 670 Lys Asn Ser Leu Arg Asn Pro Val Val Glu Lys Ile Leu Asn Gin Met 675 680 685 Page 2878 of 3790 Val Asn Val Val Asn Gin Val Ile Glu Thr Tyr Gly Lys Pro Asp Glu 690 695 700 Val Arg Ile Glu Leu Ala Arg Glu Leu Lys Lys Ser Ala Glu Glu Arg 705 710 715 720 Ala Glu Met Thr Lys Gly Ile Asn Glu Ala Thr Arg Arg Asn Glu Asp 725 730 735 Ile Lys Lys Leu Ile Thr Lys Asn Phe Gly Ile Pro Asn Pro Thr Lys 740 745 750 Asn Asp Val Val Arg Tyr Arg Leu Trp Glu Glu Leu Ala Pro Leu Ala 755 760 765 Tyr Lys Asp Val Phe Thr Gly Arg Gin Ile Lys Lys Glu Asp Leu Phe 770 775 780 Ser Ser Lys Ile Asp Ile Glu His Ile Ile Pro Lys Ala Leu Leu Phe 785 790 795 800 Asp Asp Ser Phe Ser Asn Lys Thr Leu Ala Phe Arg Glu Thr Asn Leu 805 810 815 Lys Lys Ala Asp Arg Thr Ala Tyr Gly Phe Ile Glu Ser Asp Tyr Asn 820 825 830 Ala Thr Leu Asp Asp Tyr Ile Gin Arg Val Glu Thr Leu Tyr Asn Asn 835 840 845 Ala Lys Gly Thr Ile Ser Lys Gly Lys Arg Asn Lys Leu Leu Met Ala 850 855 860 Gin Lys Asn Leu Pro Asp Gly Phe Ile Glu Arg Asp Leu Arg Asn Ser 865 870 875 880 Gin Tyr Ile Ala Lys Lys Ala Lys Ser Met Ile Glu Lys Val Phe Asn 885 890 895 Asp Val Asn Val Thr Ser Gly Ser Ile Thr Asp Arg Leu Arg Glu Asp 900 905 910 Trp Asp Leu Ile Asn Val Met Lys Glu Leu Asn Phe Pro Lys Tyr Lys 915 920 925 Ala Leu Gly Leu Thr Glu Ile Glu Glu Arg Tyr Asp Ile Gly Gin Glu 930 935 940 Page 2879 of 3790 Page 2880 of 3790 Glu Tyr 1400 1161 Page 2881 of 3790 1128 PRT Roseburia intestinalis 130 135 140 Leu Gly Asn Lys Lys Ala Thr Glu Glu Leu Glu Glu Lys Tyr Leu Glu Page 2883 of 3790 Lys Ala Asp Ser Lys Gly Thr Lys Gin Lys Leu Leu Thr Gly Glu Asn 485 490 495 Val Asn Gin Thr Ile Asn Glu Ile Thr Asn Pro Val Val Lys Arg Ser 500 505 510 Val Ser Gin Thr Val Lys Val Ile Asn Ala Ile Ile Arg Thr Tyr Gly 515 520 525 Ser Pro Gin Ala Ile Asn Ile Glu Leu Ala Arg Glu Met Ser Lys Thr 530 535 540 Phe Glu Glu Arg Arg Lys Ile Lys Gly Asp Met Glu Lys Arg Gin Lys 545 550 555 560 Asn Asn Glu Asp Val Lys Lys Gin Ile Gin Glu Leu Gly Lys Leu Ser 565 570 575 Pro Thr Gly Gin Asp Ile Leu Lys Tyr Arg Leu Trp Gin Glu Gin Gin 580 585 590 Gly Ile Cys Met Tyr Ser Gly Lys Thr Ile Pro Leu Glu Glu Leu Phe 595 600 605 Lys Pro Gly Tyr Asp Ile Asp His Ile Leu Pro Tyr Ser Ile Thr Phe 610 615 620 Asp Asp Ser Phe Arg Asn Lys Val Leu Val Thr Ser Gin Glu Asn Arg 625 630 635 640 Gin Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Met Gly Asn Asp Glu Gin 645 650 655 Arg Trp Asn Glu Phe Glu Thr Arg Val Lys Thr Thr Ile Arg Asp Tyr 660 665 670 Lys Lys Gin Gin Lys Leu Leu Lys Lys His Phe Ser Glu Glu Glu Arg 675 680 685 Ser Glu Phe Lys Glu Arg Asn Leu Thr Asp Thr Lys Tyr Ile Thr Thr 690 695 700 Val Ile Tyr Asn Met Ile Arg Gin Asn Leu Glu Met Ala Pro Leu Asn 705 710 715 720 Arg Pro Glu Lys Lys Lys Gin Val Arg Ala Val Asn Gly Ala Ile Thr 725 730 735 Page 2884 of 3790 Ala Tyr Leu Arg Lys Arg Trp Gly Leu Pro Gin Lys Asn Arg Glu Thr 740 745 750 Asp Thr His His Ala Met Asp Ala Val Val Ile Ala Cys Cys Thr Asp 755 760 765 Gly Met Ile Gin Lys Ile Ser Arg Tyr Thr Lys Val Arg Glu Arg Cys 770 775 780 Tyr Ser Lys Gly Thr Glu Phe Val Asp Ala Glu Thr Gly Glu Ile Phe 785 790 795 800 Arg Pro Glu Asp Tyr Ser Arg Ala Glu Trp Asp Glu Ile Phe Gly Val 805 810 815 His Ile Pro Lys Pro Trp Glu Thr Phe Arg Ala Glu Leu Asp Val Arg 820 825 830 Met Gly Asp Asp Pro Lys Gly Phe Leu Asp Thr His Ser Asp Val Ala 835 840 845 Leu Glu Leu Asp Tyr Pro Glu Tyr Ile Tyr Glu Asn Leu Arg Pro Ile 850 855 860 Phe Val Ser Arg Met Pro Asn His Lys Val Thr Gly Ala Ala His Ala 865 870 875 880 Asp Thr Ile Arg Ser Pro Arg His Phe Lys Asp Glu Gly Ile Val Leu 885 890 895 Thr Lys Thr Ala Leu Thr Asp Leu Lys Leu Asp Lys Asp Gly Glu Ile 900 905 910 Asp Gly Tyr Tyr Asn Pro Gin Ser Asp Leu Leu Leu Tyr Glu Ala Leu 915 920 925 Lys Lys Gin Leu Leu Leu Tyr Gly Asn Asp Ala Lys Lys Ala Phe Ala 930 935 940 Gin Asp Phe His Lys Pro Lys Ala Asp Gly Thr Glu Gly Pro Val Val 945 950 955 960 Arg Lys Val Lys Ile Gin Lys Lys Gin Thr Met Gly Val Phe Val Asp 965 970 975 Ser Gly Asn Gly Ile Ala Glu Asn Gly Gly Met Val Arg Ile Asp Val 980 985 990 Page 2885 of 3790 Phe Arg Val Asn Gly Lys Tyr Tyr Phe Val Pro Val Tyr Thr Ala Asp 995 1000 1005 1162 1471 PRT Scardovia wiggsiae 1162 Met Gly Tyr Lys Ala Pro Arg Asn Asp Lys Gly Glu Ile Asp Tyr Gly 15 10 15 Val Gly Leu Asp Leu Gly Asn Gly Ser Val Gly Trp Val Ala Met Asp 20 25 30 Lys Asp Tyr His Leu Ile Arg Ala Arg Gly His Glu Leu Ile Gly Ala 35 40 45 Arg Leu Phe Asp Pro Ala Asn Ser Ala Glu Asn Arg Arg Glu Ser Arg 50 55 60 Thr Thr Arg Arg Arg Leu Ser Arg Arg Arg Trp Arg Leu Arg Met Leu 65 70 75 80 Page 2886 of 3790 Asp Ser Leu Phe Ala Ser Glu Leu Ala Lys Ile Asp Pro Asn Phe Leu 85 90 95 Ala Arg Arg Lys Tyr Ser Trp Val His Pro Lys Asp Glu Gin Asn His 100 105 110 Glu Asn Trp Tyr Gly Ser Ile Ile Phe Gly Ser Lys Glu Gin Asp Lys 115 120 125 Gin Phe Tyr Lys Asp Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 130 135 140 Thr Glu Asp Thr Glu Arg His Asp Ile Arg Glu Ile Tyr Val Ala Ile 145 150 155 160 His His Ile Val Lys Tyr Arg Gly His Phe Leu Arg Glu Gly Glu Ile 165 170 175 Asn Ser Glu Asn Leu Phe Asp Pro Glu Gly Phe Val Glu Leu Ile Lys 180 185 190 Asp Val Ile Lys Leu Asn Asn Ser Tyr Asp Glu Ser Thr Pro Ile Phe 195 200 205 Glu Ala Ser Pro Ala Asp Val Ser Glu Ala Leu Leu Asn Glu His Thr 210 215 220 Ser Arg Ser Gly Arg Ile Glu Asp Thr Leu Asp Lys Leu Asp Phe Ser 225 230 235 240 Val Ser Arg Val Asp Lys His Glu Leu Lys Gly Met Arg Asp Ala Ala 245 250 255 Lys Ala Val Ile Gly Ala Ile Val Gly Asn Thr Ala Asp Phe Ser Lys 260 265 270 Ile Phe Asn Leu Asp Asn Leu Asp Lys Asp Ser Lys Asp Asn Leu Lys 275 280 285 Leu Lys Phe Ala Asp Ser Asn Phe Asp Glu Lys Tyr Gly Gly Val Val 290 295 300 Gly Ser Gly Leu Leu Asp Glu Thr Gin Ile Glu Leu Val Asp Arg Ile 305 310 315 320 His Ala Val Tyr Asp Ala Val Ala Leu Lys Gly Ile Leu Gly Asp Ala Page 2888 of 3790 Thr Leu Pro Gin His Ser Leu Leu Tyr Glu Glu Tyr Met Val Leu Ser 580 585 590 Glu Leu Asn Asn Val Arg Leu Asn Val Arg Gin Gly Asn His Trp Ser 595 600 605 Asp Lys Asn Arg Gin Arg Leu Ser Tyr Lys Gin Lys Glu Phe Leu Ile 610 615 620 Glu Asn Leu Phe Lys Glu His Lys Thr Val Thr Arg Lys Arg Ala Glu 625 630 635 640 Asp Cys Leu Ser Ser Met Gly Cys Gly Glu Val Gin Leu Phe Gly Leu 645 650 655 Ser Asp Glu Lys Lys Phe Ala Ser Ser Leu Ser Ser Tyr Ile Thr Leu 660 665 670 Lys Lys Ile Leu Gly Lys Ala Phe Val Asp Asp Ser Gly Asn Ser Ala 675 680 685 Ile Leu Glu Arg Ile Ile Glu Val Gin Thr Val Phe Glu Asp Arg Glu 690 695 700 Pro Leu Thr His Gin Leu Ser Leu Ile Asp Ser Leu Thr Val Glu Gin 705 710 715 720 Arg Lys Gin Leu Ala Lys Ile His Tyr Thr Gly Trp Gly Lys Leu Ser 725 730 735 Arg Lys Leu Leu Thr Ser Lys Lys Gly Ser Tyr Lys Ile His Ser Gin 740 745 750 Asn Glu Ile Met Arg Thr Gin His Ser Ile Ile Asp Ile Met Arg Gly 755 760 765 Asp Ser Leu Asn Leu Ile Glu Ile Ile Arg Asp Lys Lys Ile Gly Ile 770 775 780 Gly Glu Trp Ile Asp Asn Glu Asn Leu Asp Arg Glu Thr Gly Glu Ser 785 790 795 800 Asp Val Ser Arg Leu Glu Ser Val Phe Glu Gly Ile Val Met Ser Pro 805 810 815 Arg Val Lys Arg Gly Val Val Gin Ala Val Arg Val Ile Asp Asp Leu 820 825 830 Page 2889 of 3790 Page 2890 of 3790 Asp Ile Ile Leu Lys Ser Lys Asp Ile Glu Asp Ala Ala His Lys Thr Leu Lys Gin Gly Asp Phe Val 20 Tyr Val 25 Pro Asp Asp Asn 30 Glu Glu Val Ile Leu Asp Glu Ser 35 Ser Pro 40 Leu Phe Ile Asp Tyr 45 Trp Lys Asn Ile Ser Glu Arg Ser Asn Asn Ile His Val Val Gin Lys Phe Ser Gly Page 2892 of 3790 130 135 140 Val Ile Tyr Lys Tyr Asn Gin Leu Arg Gly Tyr Ser Gly Gly Asn Ser Page 2894 of 3790 Val Phe Gin Glu Tyr Lys Ile Trp Glu Gin Ile Asn Lys Leu Val Ile 405 410 415 Asn Thr Lys Ile Glu Asn Gly Val Asn Arg Lys Gly Glu Ile Arg Tyr 420 425 430 Lys Tyr Ile Asp Lys Pro Ile Pro Val Ala Leu Lys Glu Trp Leu Tyr 435 440 445 Glu Glu Leu Gin Ser Lys Lys Glu Val Ser Phe Asn Pro Ile Leu Thr 450 455 460 Lys Leu Lys Lys Glu Phe Lys Leu Arg Glu Asn Val Asp Phe Leu Asn 465 470 475 480 Gly Met Asn Ala Lys Asp Lys Leu Lys Gly Asn Glu Thr Lys Val Ile 485 490 495 Leu Gin Lys Ala Leu Gly Glu Leu Trp Asn Ile Phe Gly Leu Asp Asp 500 505 510 Ser Glu Arg Gin Val Glu Leu Trp Glu Ile Leu Tyr Asn Gly Lys Gly 515 520 525 Asn Glu Tyr Asp Leu Thr Ser Glu Arg Thr Ser Asn Ile Leu Ala Phe 530 535 540 Ile Glu Lys Tyr Ser Pro Asp Leu Glu Asn Lys Asn Asp Val Ala Ile 545 550 555 560 Lys Ile Ser Lys Ile Lys Phe Ser Arg Asn Tyr Ser Asn Leu Ser Leu 565 570 575 Lys Ala Ile Asp Asn Ile Leu Pro Leu Val Arg Ala Gly Lys Phe Phe 580 585 590 Asp Gin Asn Phe Ser Glu Ala Leu Ser His Lys Ile Val Lys Leu Leu 595 600 605 Asn Glu Asn Val Glu Asp Pro Phe Glu Lys Ser Ala Gin Glu Phe Leu 610 615 620 Asp Lys Asn Gin Asp Val Leu Ser Asp Gly Gly Ile Val Asn Ala Ile 625 630 635 640 Ala Thr Ile Leu Val Tyr Asp Lys His Thr Ala Lys Glu Tyr Ser Gly 645 650 655 Page 2895 of 3790 Asp Glu Leu Ile Lys Glu Phe Thr Gin Ile Ser Arg Leu Lys Gin Gly 660 665 670 Glu Leu Arg Asn Pro Leu Ala Glu Gin Ile Ile Asn Glu Ala Leu Val 675 680 685 Ile Val Arg Asp Ile Trp Arg Lys Tyr Gly Phe Lys Pro Asp Glu Ile 690 695 700 Arg Val Glu Leu Ala Arg Glu Leu Lys Asn Asn Ala Val Glu Arg Gly 705 710 715 720 Lys Met Tyr Ser Ala Asn Leu Lys Ser Gin Lys His Asn Ala Glu Ile 725 730 735 Arg Asn Lys Leu Ile Glu Leu Lys Gin Glu Ile Ser Ile Ala Asn Ile 740 745 750 Glu Lys Tyr Lys Leu Trp Val Ser Gin Glu Asn Leu Gin Glu Val Tyr 755 760 765 Leu Lys Asn Tyr Asn Asp Pro Ser Lys Ser Glu Ile Glu Lys Leu Lys 770 775 780 Leu Trp Glu Ser Gin Gly His Ile Ser Pro Tyr Thr Gly Gin Pro Ile 785 790 795 800 Ser Leu Ser Glu Leu Phe Asn Arg Glu Arg Tyr Asp Val Asp His Ile 805 810 815 Ile Pro Gin Ser Arg Tyr Phe Asp Asp Ser Leu Ser Asn Lys Val Ile 820 825 830 Cys Glu Lys Ser Ile Asn Asn Glu Lys Gly Asn Arg Thr Ser Met Glu 835 840 845 Tyr Phe Glu Val Gly Ser Val Asn Tyr Arg Ile Phe Thr Lys Asp Gin 850 855 860 Phe Ile Asp His Ala Asn Lys Tyr Phe Ser Gly Lys Lys Arg Lys Asn 865 870 875 880 Leu Leu Ala Thr Ser Ile Pro Glu Asp Pro Ile Gin Arg Gin Ile Lys 885 890 895 Asp Thr Gin Tyr Ile Ser Ile Arg Ile Arg Glu Glu Leu Asn Lys Ile 900 905 910 Page 2896 of 3790 Tyr Gly Leu Ser Asn Gly Lys Glu Ile Tyr Arg Ile Pro Ile Asn 1165 1110 PRT Sphingobium sp. 1165 Met Ala Glu Gly Lys Lys Arg Ile Trp Arg Leu Gly Ala Asp Leu Gly 15 10 15 Ala Asn Ser Leu Gly Trp Ala Ala Ile Glu Leu Ser Ala Pro Val Asn 20 25 30 Gly Lys Pro Ile Ala Ile Leu Ala Ala Gly Ser Arg Ile Phe Ser Asp 35 40 45 Gly Arg Asp Pro Lys Ser Gly Ala Ser Leu Ala Val Asp Arg Arg Asp Page 2898 of 3790 55 60 Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Phe Lys Gin Arg Gin Lys 65 70 75 80 Ala Leu Ile Lys Tyr Leu Ile Ala Asp Gly Leu Phe Pro Ala Asp Glu 85 90 95 Ala Ala Arg Asn Ala Met Ala Ala Ile Asp Pro Tyr Ala Val Arg Ala 100 105 110 Arg Ala Leu Asp Glu Ala Leu Ser Leu Pro Glu Leu Gly Arg Ala Leu 115 120 125 Phe His Leu Asn Gin Arg Arg Gly Phe Lys Ser Asn Arg Lys Ala Asp 130 135 140 Arg Lys Ala Asp Asp Asp Ala Gly Lys Ile Ala Ile Gly Ile Asp Arg 145 150 155 160 Thr Arg Asp Ala Ile Ala Glu Asp Glu Ala Asp Ala Gly Ala Glu Pro 165 170 175 Gly Ser Trp Thr Phe Gly Lys Trp Leu His Glu Arg Arg Leu Lys Gly 180 185 190 Gin Ser Val Arg Thr Arg Leu Arg Pro Glu Ser Gly Glu Asp Ala Lys 195 200 205 Gly Asp Gly Tyr Asp Phe Tyr Pro Asp Arg Ala Leu Met Glu Glu Glu 210 215 220 Phe Asp Ala Ile Trp Ala Ala Gin Ala Pro His His Pro Asp Val Leu 225 230 235 240 Thr Asn Asp Val His Asp Arg Leu His Glu Ile Ile Phe Tyr Gin Arg 245 250 255 Pro Leu Lys Ala Pro Gin Val Gly Met Cys Ser Leu Ile Pro Gly Asp 260 265 270 Arg Arg Leu Pro Lys Ala His Pro Leu Phe Gin Arg Arg Arg Leu Leu 275 280 285 Glu Glu Leu Asn Ala Leu Met Ile Val Arg Pro Gly Glu Val Ala Gin 290 295 300 Page 2899 of 3790 Arg Leu Thr Arg Glu Glu Arg Asp Ile Leu Leu Leu Lys Leu Lys Asp 305 310 315 320 Lys Asn Lys Val Ser Phe Ala Thr Leu Arg Lys Ala Leu Lys Leu Asp 325 330 335 Pro Asp Ala Arg Phe Asn Lys Glu Ser Glu Asp Arg Thr Asp Leu Lys 340 345 350 Gly Asp Glu Val Ala Ala Val Met Gly Ser Lys Thr Arg Phe Gly Asn 355 360 365 Leu Trp Val His Leu Ser Ile Glu Ala Gin Trp Asp Val Leu Ala Arg 370 375 380 Leu Asp Ala Val Glu Ser Asp Ala Glu Asp Ala Ala Phe Cys Ala Trp 385 390 395 400 Leu Val Glu Thr Tyr Ala Leu Thr Pro Glu Gin Ala Arg Ala Val Ala 405 410 415 Asn Ala Pro Leu Pro Pro Gly Tyr Gly Arg Phe Gly Glu Thr Ala Thr 420 425 430 Arg Lys Leu Ile Glu Ala Leu Arg Asp Gly Lys Lys Asp Asp Arg Val 435 440 445 Leu Val Tyr Ser Glu Ala Val Thr Glu Ala Gly Leu Gly His His Ser 450 455 460 Asp Arg Arg Thr Gly Glu Val Phe Glu Asp Ala Lys Gly Arg Pro Gin 465 470 475 480 Leu Pro Tyr Tyr Gly Val Ala Leu Glu Arg His Ile Met Pro Gly Thr 485 490 495 Gly Asp Pro Ser Asp Pro Glu Glu Met Arg Val Gly Arg Leu Thr Asn 500 505 510 Pro Thr Val His Ile Gly Leu Asn Gin Leu Arg Arg Ile Leu Asn Val 515 520 525 Leu Ile Arg Ala Tyr Gly Pro Pro Ala Glu Ile Ala Ile Glu Leu Ala 530 535 540 Arg Glu Leu Lys Leu Thr Asp Glu Asp Lys Lys Arg Ile Asn Arg Glu 545 550 555 560 Page 2900 of 3790 Asn Asn Asp Asn Arg Ile Ala Ala Glu Arg Arg Ser Glu Lys Leu Leu 565 570 575 Ala Ile Gly Gin Ala Asp Ser Gly Ala Asn Arg Ala Leu Leu Lys Leu 580 585 590 Trp Glu Glu Leu Asn Pro Ala Asn Val Leu Asp Arg Arg Cys Ile Tyr 595 600 605 Ser Gly Arg Gin Ile Ser Ile Asp Met Leu Phe Ser Ala Ala Val Glu 610 615 620 Val Asp His Ile Leu Pro Phe Ala Ala Thr Leu Asp Asp Ser Asn Gly 625 630 635 640 Asn Lys Ile Val Cys Leu Arg Glu Ala Asn Arg Glu Lys Arg Lys Arg 645 650 655 Ser Pro His Asp Ala Trp Gly His Ser Ala Arg Trp Asp Glu Ile Ala 660 665 670 Ala Arg Ala Ala Gin Leu Pro Arg Asn Lys Arg Trp Arg Phe Glu Pro 675 680 685 Asp Ala Met Asp Lys Phe Arg Asp Glu Gly Gly Phe Gin Ala Arg His 690 695 700 Leu Val Asp Thr Gin Tyr Leu Ala Arg Leu Ser Arg Glu Tyr Leu Ala 705 710 715 720 Thr Leu Tyr Pro Glu Lys Gly Glu Gly Ser Gly His Ile Trp Val Ser 725 730 735 Pro Gly Arg Leu Thr Glu Met Val Arg Arg Lys Leu Gly Leu Asn Asp 740 745 750 Leu Leu Pro Asp His Asn Phe Gly Gly Gly Ala Asp Gin Ala Lys Asn 755 760 765 Arg Leu Asp His Arg His His Ala Ile Asp Ala Val Val Val Ala Ile 770 775 780 Val Asp Arg Gly Met Leu Asn Ala Ile Ala Arg Ala Ser Gly Gin Glu 785 790 795 800 Gly Ala Glu Gly Arg Glu Arg Ile Ile Ile Pro Glu Pro Trp Asp Gly 805 810 815 Page 2901 of 3790 Asp Leu Lys Lys Arg Asp Ala Val Ser Asn Asp Asp Asp Pro Phe Page 2902 of 3790 1055 1060 1065 1100 1105 1110 1166 1084 PRT Sporolactobacillus vineae Gin Thr Val Ala Glu Met Leu Val Asn Glu Pro Glu Thr Phe Ala Gly Page 2904 of 3790 Leu Ser Leu Ser Phe Ala Lys Phe Gly His Leu Ser Leu Lys Ala Leu 420 425 430 His Lys Leu Ile Pro His Met Glu Gin Gly Leu Ser Tyr Tyr Asp Ala 435 440 445 Cys Lys Lys Val Gly Tyr His Asp Asn Glu Gin Val Gly Lys Ser Lys 450 455 460 Gin His Leu Leu Pro Val Ile Pro Ala Asp Glu Ile Arg Asn Pro Val 465 470 475 480 Val Val Arg Ser Leu Ser Gin Thr Arg Lys Val Ile Asn Ala Ile Ile 485 490 495 Lys Arg Tyr Gly Ser Pro Thr Phe Met Tyr Ile Glu Leu Ala Arg Glu 500 505 510 Met Gly Arg Pro Tyr Asn Glu Arg Arg Asp Leu Glu Lys Gin Tyr Asn 515 520 525 Lys Asn Arg Thr Val Asn Asp Ser Ala Ile Glu Gin Ile His Glu Leu 530 535 540 Tyr Pro Glu Ile Gly Ala Pro Arg Gly His Asp Ile Leu Lys Tyr Lys 545 550 555 560 Leu Trp Gin Gin Gin Asp Cys Lys Cys Ala Tyr Ser Leu Glu Lys Ile 565 570 575 Pro Ala Glu Lys Ile Phe Glu Pro Gly Tyr Ala Glu Val Asp His Ile 580 585 590 Ile Pro Tyr Ser Arg Ser Phe Asp Asp Ser Asn Ser Asn Lys Val Leu 595 600 605 Val Leu Ser Arg Met Asn Gin Glu Lys Lys Asn Arg Thr Pro Tyr Glu 610 615 620 Trp Phe Gly Gly Asp Glu His Arg Trp Asn Lys Phe Glu Ser Tyr Val 625 630 635 640 Asn Ala Leu Lys Val Asn Arg Lys Lys Lys Ser Leu Leu Thr Lys Lys 645 650 655 Asn Met Asp Thr Glu Glu Glu Asp Thr Phe Lys Ser Arg His Leu Asn 660 665 670 Page 2905 of 3790 Asp Thr Arg Tyr Ile Thr Arg Phe Ile Lys Ser Phe Val Glu Asp Asn 675 680 685 Leu Leu Phe Arg Glu Ile Glu Gly Ala Lys Gin His Val Phe Thr Val 690 695 700 Asn Gly Ala Tyr Thr Ser Leu Met Arg Lys Arg Trp Gly Phe Asn Lys 705 710 715 720 Asn Arg Glu Glu Ser Asp Leu His His Ser Val Asp Ala Val Ile Ile 725 730 735 Ala Val Ser Gin Pro Phe Arg Asn Glu Val Ser Arg Tyr Phe Lys His 740 745 750 Arg Glu Ile Ser Leu Pro Gin Leu Leu Lys Arg Thr Trp Asp Tyr Phe 755 760 765 Pro Glu Pro Trp Glu Gly Phe Val Lys Glu Leu Arg Ala Arg Thr Leu 770 775 780 Gin Asp Pro Glu Lys Leu Lys Leu Ala Leu Glu Ser Leu Asp Leu Asp 785 790 795 800 Ser Tyr Asp Pro Glu Phe Ile Asp Glu Val Lys Pro Ile Phe Ile Ser 805 810 815 Arg Met Pro Lys Arg Ser Ile Lys Gly Gin Ile His Asp Glu Thr Leu 820 825 830 Arg Arg Asn Arg Gly Lys Thr Lys Asp Gly Phe Val Lys Ile Val Thr 835 840 845 Arg Thr Arg Leu Glu Asn Ile Lys Phe Asp Lys Asn Gly Asp Phe Pro 850 855 860 Met Tyr Gly Arg Glu Ser Asp Pro Lys Thr Tyr Gin Ala Ile Lys Gin 865 870 875 880 Arg Tyr Leu Glu Asn Asn Lys Asp Lys Lys Lys Ala Phe Ile Glu Pro 885 890 895 Leu Tyr Lys Pro Ala Lys Asn Pro Asn Asn Ala Ser Leu Ile Arg Ser 900 905 910 Val Lys Ile Glu Asp Lys Ala Asn Gin Ile Val Pro Leu Arg Asp Glu 915 920 925 Page 2906 of 3790 1070 1075 1080 Ser 1167 475 PRT Staphylococcus massiliensis 1167 Page 2907 of 3790 Ser Lys Arg Gly Ser Arg Arg Leu Gin Arg Arg Arg Lys His Arg Leu 50 55 60 Ala Arg Thr Arg Asn Leu Leu Glu Ser Tyr Gin Leu Asn Pro Phe Pro 65 70 75 80 Lys Cys Glu Lys Asn Pro Tyr Glu Ile Arg Val Lys Gly Phe Lys Glu 85 90 95 Val Leu Thr Ser Asp Glu Leu Ser Ala Ala Leu Leu His Leu Ala Lys 100 105 110 Arg Arg Gly Ile Asp Asn Val His Val Thr Asp Thr Glu Ser Asp Ser 115 120 125 Ser Asp Asn Gly Leu Ser Thr Lys Glu Gin Leu Ala Lys Asn Gin Lys 130 135 140 Ala Leu Glu Ser Arg Tyr Val Cys Glu Leu Gin Leu Glu Arg Leu Leu 145 150 155 160 Asn Asp Asn Lys Val Arg Gly Ala Asn Asn Arg Phe Lys Thr Gin Asp 165 170 175 Phe Val Arg Glu Ala Lys Gin Ile Leu Ser Ile Gin Lys Asp His His 180 185 190 Asn Leu Asp Gin Val Phe Ile Asp Lys Tyr Ile Ser Leu Leu Glu Thr 195 200 205 Arg Arg Glu Tyr Tyr Glu Gly Pro Gly Lys Gly Ser Pro Tyr Gly Trp 210 215 220 Asp Gly Asp Ile Lys Lys Trp Tyr Glu Leu Leu Met Gly Arg Cys Thr 225 230 235 240 Tyr Phe Pro Glu Ser Leu Arg Ser Val Lys Tyr Ala Tyr Ser Ala Asp 245 250 255 Leu Phe Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Val Arg Asp 260 265 270 Glu Asn Asp Lys Leu Thr Tyr Pro Glu Lys Tyr His Ile Val Glu Asn 275 280 285 Val Phe Lys Gin Arg Lys Lys Pro Thr Leu Lys Gin Ile Ala Lys Glu Arg Asp Leu Val Asp Lys Val Ile Lys Glu Thr Gly Lys Thr Lys Ala Page 2909 of 3790 40 45 Lys Gly Met Val Glu Lys Leu Ile Leu His Asp Lys Gin Glu Gly Lys 50 55 60 Cys Leu Tyr Ser Leu Lys Ser Ile Pro Leu Glu Asp Leu Leu Asn Asn 65 70 75 80 Pro His His Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Tyr 85 90 95 Asp Asn Ser Met Asn Asn Lys Val Leu Val Leu Gin Glu Glu Asn Ser 100 105 110 Lys Lys Ser Asn Gin Thr Pro Phe Gin Tyr Phe Asn Ser Ser Asn Thr 115 120 125 His Ile Thr Phe Lys Gin Phe Lys Gin His Val Leu Asn Leu Ser Lys 130 135 140 Thr Lys Asp Arg Ile Thr Lys Lys Lys Lys Glu Tyr Leu Leu Glu Glu 145 150 155 160 Arg Asp Ile Asn Lys Phe Ser Val Gin Lys Glu Phe Ile Asn Arg Asn 165 170 175 Leu Val Asp Thr Arg Tyr Ala Thr Arg Glu Leu Met Thr Leu Leu Arg 180 185 190 Ala Tyr Phe Ser Ala Asn Glu Leu Asp Val Lys Val Lys Ala Ile Asn 195 200 205 Gly Gly Phe Thr Ser Tyr Leu Arg Lys Arg Trp Asp Phe Lys Lys Asp 210 215 220 Arg Asn Ala Gly Tyr Lys His His Ala Glu Asp Ala Leu Ile Ile Ala 225 230 235 240 Asn Val Asp Phe Ile Phe Lys Gin Leu Lys Ala Leu Asp Asn Ala Lys 245 250 255 Lys Val Met Glu Gly Arg Lys Val Gin Val Glu Lys Asp Asn Val Glu 260 265 270 Asp Asn Glu His Tyr Glu Ser Leu Phe Arg Glu Pro Asp Gin Ile Lys 275 280 285 Page 2910 of 3790 Glu Ile Lys Leu Tyr Asp Asn Tyr Lys Phe Ser His Arg Val Asp Lys 290 295 300 Lys Pro Asn Arg Glu Leu Ile Asn Asp Thr Ile Tyr Ser Thr Arg Lys 305 310 315 320 Val Asp Asn Lys Thr Tyr Thr Ile Gin Thr Val Asn Asn Ile Tyr Asp 325 330 335 Lys Gin Asn Asp Gin Leu Lys Lys Leu Phe Asn Lys Ser Pro Glu Lys 340 345 350 Phe Leu Met Tyr Lys His Asp Pro Lys Thr Phe Asp Lys Leu Ala Thr 355 360 365 Ile Met Arg Gin Tyr Lys Asn Glu Lys Asn Pro Leu Tyr Lys Phe His 370 375 380 Asp Glu Thr Gly Glu Tyr Leu Thr Lys Tyr Ala Lys Lys Asp Asn Gly 385 390 395 400 Pro Ile Val Lys Ser Leu Lys Tyr Ile Gly Lys Gin Val Asn Ala His 405 410 415 Leu Asp Ile Thr Asn Asp Tyr Glu Asn Ser Asn Asn Lys Val Val Lys 420 425 430 Leu Ser Leu Lys Pro Phe Arg Phe Asp Val Tyr Leu Asp Asp Gly Lys 435 440 445 Tyr Lys Phe Val Thr Val Lys Tyr Leu Asp Ile Ile Lys Lys Asp Thr 450 455 460 Tyr Tyr Val Ile Asp Glu Glu Lys Tyr Lys Leu Ala Leu Gin Gin Lys 465 470 475 480 Lys Ile Ser Glu Asn Ala Lys Phe Ile Gly Ser Phe Tyr Asn Asn Asp 485 490 495 Leu Ile Lys Ile Asn Gly Glu Leu Leu Arg Val Ile Gly Val Asn Asp 500 505 510 Asp Ala Lys Asn Thr Leu Glu Leu Asn Met Ile Asp Ile Ser Tyr Arg 515 520 525 Asp Tyr Val Glu Asn Met Asn Leu Ala Thr Thr Pro Arg Ile Arg Lys 530 535 540 Page 2911 of 3790 Lys Ile Glu Asn Leu Thr Asn Asn Asp Asn Met His Asp Phe Val Glu 165 170 175 Page 2912 of 3790 Leu Ile Glu Thr Tyr Glu Asn Leu Asn Asn Ile Lys Leu Asn Leu Asp 180 185 190 Tyr Glu Lys Thr Lys Val Ile Tyr Glu Ile Leu Lys Asp Asn Glu Met 195 200 205 Thr Lys Asn Asp Arg Ala Lys Arg Val Lys Asn Met Glu Lys Lys Leu 210 215 220 Glu Gin Phe Ser Ile Met Leu Leu Gly Leu Lys Phe Asn Glu Gly Lys 225 230 235 240 Leu Phe Asn His Ala Asp Asn Ala Glu Glu Leu Lys Gly Ala Asn Gin 245 250 255 Ser His Thr Phe Ala Asp Asn Tyr Glu Glu Asn Leu Thr Pro Phe Leu 260 265 270 Thr Val Glu Gin Ser Glu Phe Ile Glu Arg Ala Asn Lys Ile Tyr Leu 275 280 285 Ser Leu Thr Leu Gin Asp Ile Leu Lys Gly Lys Lys Ser Met Ala Met 290 295 300 Ser Lys Val Ala Ala Tyr Asp Lys Phe Arg Asn Glu Leu Lys Gin Val 305 310 315 320 Lys Asp Ile Val Tyr Lys Ala Asp Ser Thr Arg Thr Gin Phe Lys Lys 325 330 335 Ile Phe Val Ser Ser Lys Lys Ser Leu Lys Gin Tyr Asp Ala Thr Pro 340 345 350 Asn Asp Gin Thr Phe Ser Ser Leu Cys Leu Phe Asp Gin Tyr Leu Ile 355 360 365 Arg Pro Lys Lys Gin Tyr Ser Leu Leu Ile Lys Glu Leu Lys Lys Ile 370 375 380 Ile Pro Gin Asp Ser Glu Leu Tyr Phe Glu Ala Glu Asn Asp Thr Leu 385 390 395 400 Leu Lys Val Leu Asn Thr Thr Asp Asn Ala Ser Ile Pro Met Gin Ile 405 410 415 Asn Leu Tyr Glu Ala Glu Thr Ile Leu Arg Asn Gin Gin Lys Tyr His 420 425 430 Page 2913 of 3790 Ala Glu Ile Thr Asp Glu Met Ile Glu Lys Val Leu Ser Leu Ile Gin 435 440 445 Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Val Asn Asp His Thr Ala 450 455 460 Ser Lys Phe Gly Trp Met Glu Arg Lys Ser Asn Glu Ser Ile Lys Pro 465 470 475 480 Trp Asn Phe Asp Glu Val Val Asp Arg Ser Lys Ser Ala Thr Gin Phe 485 490 495 Ile Arg Arg Met Thr Asn Lys Cys Ser Tyr Leu Ile Asn Glu Asp Val 500 505 510 Leu Pro Lys Asn Ser Leu Leu Tyr Gin Glu Met Glu Val Leu Asn Glu 515 520 525 Leu Asn Ala Thr Gin Ile Arg Leu Gin Thr Asp Pro Lys Asn Arg Lys 530 535 540 Tyr Arg Met Met Pro Gin Ile Lys Leu Phe Ala Val Glu His Ile Phe 545 550 555 560 Lys Lys Tyr Lys Thr Val Ser His Ser Lys Phe Leu Glu Ile Met Leu 565 570 575 Asn Ser Asn His Arg Glu Asn Phe Met Asn His Gly Glu Lys Leu Ser 580 585 590 Ile Phe Gly Thr Gin Asp Asp Lys Lys Phe Ala Ser Lys Leu Ser Ser 595 600 605 Tyr Gin Asp Met Thr Lys Ile Phe Gly Asp Ile Glu Gly Lys Arg Ala 610 615 620 Gin Ile Glu Glu Ile Ile Gin Trp Ile Thr Ile Phe Glu Asp Lys Lys 625 630 635 640 Ile Leu Val Gin Lys Leu Lys Glu Cys Tyr Pro Glu Leu Thr Ser Lys 645 650 655 Gin Ile Asn Gin Leu Lys Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu 660 665 670 Ser Glu Lys Leu Leu Thr His Ala Tyr Gin Gly His Ser Ile Ile Glu Page 2914 of 3790 675 680 685 Leu Leu Arg His Ser Asp Glu Asn Phe Met Glu Ile Leu Thr Asn Asp 690 695 700 Val Tyr Gly Phe Gin Asn Phe Ile Lys Glu Glu Asn Gin Val Gin Ser 705 710 715 720 Asn Lys Ile Gin His Gin Asp Ile Ala Asn Leu Thr Thr Ser Pro Ala 725 730 735 Leu Lys Lys Gly Ile Trp Ser Thr Ile Lys Leu Val Arg Glu Leu Thr 740 745 750 Ser Ile Phe Gly Glu Pro Glu Lys Ile Ile Met Glu Phe Ala Thr Glu 755 760 765 Asp Gin Gin Lys Gly Lys Lys Gin Lys Ser Arg Lys Gin Leu Trp Asp 770 775 780 Asp Asn Ile Lys Lys Asn Lys Leu Lys Ser Val Asp Glu Tyr Lys Tyr 785 790 795 800 Ile Ile Asp Val Ala Asn Lys Leu Asn Asn Glu Gin Leu Gin Gin Glu 805 810 815 Lys Leu Trp Leu Tyr Leu Ser Gin Asn Gly Lys Cys Met Tyr Ser Gly 820 825 830 Gin Ser Ile Asp Leu Asp Ala Leu Leu Ser Pro Asn Ala Thr Lys His 835 840 845 Tyr Glu Val Asp His Ile Phe Pro Arg Ser Phe Ile Lys Asp Asp Ser 850 855 860 Ile Asp Asn Lys Val Leu Val Ile Lys Lys Met Asn Gin Thr Lys Gly 865 870 875 880 Asp Gin Val Pro Leu Gin Phe Ile Gin Gin Pro Tyr Glu Arg Ile Ala 885 890 895 Tyr Trp Lys Ser Leu Asn Lys Ala Gly Leu Ile Ser Asp Ser Lys Leu 900 905 910 His Lys Leu Met Lys Pro Glu Phe Thr Ala Met Asp Lys Glu Gly Phe 915 920 925 Page 2915 of 3790 Page 2916 of 3790 1325 1330 1170 1112 PRT Staphylococcus simulans Page 2917 of 3790 Glu Gin Leu Asn Phe Ile Glu Ser Ala Asn Thr Phe Phe Met Gly Ile 50 55 60 Met Leu Asp Arg Ile Leu Lys Gly Ala Thr Ser Ile Ser Ala Ala Lys 65 70 75 80 Val Arg Asp Tyr Lys Ile Phe Lys Ser Gin Leu Lys Leu Ile Lys Asp 85 90 95 Ile Val Tyr Gin Asn Lys Tyr Asp Lys Tyr His Glu Phe Phe Val Thr 100 105 110 Ser Lys Glu Asp Met Arg Ala Tyr Gin Glu Asn Pro Asp Ala Lys Asn 115 120 125 Phe Gly Lys Leu Ser Lys Phe Asp Gin Tyr Leu Ile His Ser Lys Asp 130 135 140 Gin Tyr Ala Lys Leu Met Lys Asp Leu Lys Gly Leu Val Pro Lys Glu 145 150 155 160 Tyr Thr Glu Val Leu Asn Leu Ile Asp Glu Gin Lys Phe Leu Val Val 165 170 175 Gin Asn Thr Thr Asp Asn Ala Ser Ile Pro Tyr Gin Asn Asn Val Phe 180 185 190 Glu Ala Glu Asn Ile Leu Arg Asn Gin Gin Lys Tyr Tyr Pro Glu Ile 195 200 205 Thr Glu Glu Met Ile Gly Lys Val Ile Asn Leu Ile Ser Phe Arg Ile 210 215 220 Pro Tyr Tyr Val Gly Pro Leu Thr Asn Lys Asn Gly Gin Ser Asp Phe 225 230 235 240 Ala Trp Met Ile Arg Lys Ser Asp Glu Gin Thr Leu Pro Trp Asn Phe 245 250 255 Asp Lys Val Ile Asp Lys Ser Lys Ser Ala Glu Lys Phe Ile Arg Arg 260 265 270 Met Thr Ser Lys Cys Thr Tyr Leu Leu Glu Glu Asp Val Leu Pro Lys 275 280 285 His Ser Leu Leu Tyr Gin Glu Met Glu Val Leu Asn Glu Leu Asn Asn 290 295 300 Page 2918 of 3790 Val Gin Leu Arg Gly Glu Asn Glu Pro Lys His Arg Ile His Arg Leu 305 310 315 320 Asp Pro Lys Val Lys Gin Phe Ile Tyr His Asn Leu Phe Gin Lys Lys 325 330 335 Lys Asn Val Thr His Lys Asp Leu Ile Thr Leu Leu Gin Asn Ser Glu 340 345 350 His Arg Asn Thr Leu Asn Lys Thr Ser Gly Gin Lys Leu Lys Val Phe 355 360 365 Gly Thr Gin Asn Asp Ser Lys Phe Ala Ser Lys Leu Ser Thr Tyr Asn 370 375 380 Asp Met Lys Ala Ile Leu Gly Ser Val Glu Asn Lys Arg Gin Met Ile 385 390 395 400 Glu Glu Leu Val Leu Trp Ile Thr Ile Phe Glu Asp Lys Ala Ile Leu 405 410 415 Lys Gin Lys Ile Gly Glu Lys Tyr Pro Asn Ile Thr Glu Lys Gin Leu 420 425 430 Asn Gin Ile Val Lys Leu Asn Tyr Ser Gly Trp Gly Arg Leu Ser Glu 435 440 445 Lys Leu Leu Thr Lys Glu Val Asn Gly Arg Ser Leu Ile Asp Leu Met 450 455 460 Tyr Ser Thr Glu Asn Asn Phe Met Glu Ile Ile Thr Asp Lys Thr Leu 465 470 475 480 Gly Phe Asp Cys Phe Ile Lys Asn Ser Asn Lys Val Lys Asn Ala Lys 485 490 495 Ile Ser Tyr Lys Asp Val Ala Glu Leu Arg Thr Ser Pro Ala Leu Lys 500 505 510 Lys Gly Ile Trp Asn Ala Ile Lys Met Val Arg Glu Ile Ser Asn Leu 515 520 525 Phe Gly Ala Pro Glu Lys Ile Ile Ile Glu Phe Ala Thr Glu Asp Gin 530 535 540 Ala Lys Gly Lys Arg Gin Lys Ser Arg Ser Glu Leu Trp Asp Asp Leu Page 2920 of 3790 Page 2921 of 3790 1171 773 PRT Streptococcus agalactiae Page 2922 of 3790 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Ser Lys Gin Tyr Gin Asp Phe Leu Glu Ile 180 185 190 Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gin Asn Val Asp 195 200 205 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys Tyr 245 250 255 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gin Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gin Glu Ile Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Page 2923 of 3790 Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 530 535 540 Lys Gin Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 545 550 555 560 Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 565 570 575 Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 595 600 605 Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gin Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 625 630 635 640 Tyr Lys Asp Leu Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 660 670 Page 2924 of 3790 665 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg Page 2926 of 3790 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Gin Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 530 535 540 Lys Gin Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 545 550 555 560 Lys Lys Gin Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 565 570 575 Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 595 600 605 Page 2927 of 3790 Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gin Thr 610 615 620 Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 625 630 635 640 Tyr Lys Asp Leu Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asp Arg Glu Ser Gin Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 675 680 685 Gly Arg Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu 690 695 700 Ser Phe Lys Ser Ile Ile Ser Lys Ala Gin Ser Gly Ser His Ser Asp 705 710 715 720 Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Tyr Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Asn Gin Gly Arg Arg Asn Ser Arg Gin Arg Tyr Lys Leu 770 775 780 Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 785 790 795 800 Leu Lys Glu Tyr Pro Thr Asp Asn Gin Ala Leu Gin Asn Glu Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 820 825 830 Leu Asp Ile Asp Asn Leu Ser Gin Tyr Asp Ile Asp His Ile Val Pro 835 840 845 Gin Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 850 855 860 Page 2928 of 3790 Gin Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Ala His Ser Asn Page 2930 of 3790 Thr Ser Thr Lys Glu Val Leu Asp Ser Thr Leu Ile His Gin Ser 1340 1345 1350 Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Gly Lys Leu Gly Page 2931 of 3790 Val Arg Asn Thr Asp Ile Gin Lys Gin Tyr Gin Ala Phe Leu Glu Ile 180 185 190 Phe Asp Thr Ser Phe Glu Asn Asn His Leu Leu Ser Gin Asn Val Asp 195 200 205 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Tyr Met Ile Gin Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gin Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gin Glu Ile Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Asp Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Page 2932 of 3790 Phe Leu Lys Glu Asn Gin Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Val 530 535 540 Lys Gin Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 545 550 555 560 Lys Lys Gin Leu Leu Asp Phe Leu Ala Lys Glu Phe Glu Glu Phe Arg 565 570 575 Ile Val Asp Val Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 595 600 605 Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gin Thr 610 615 620 Ile Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 625 630 635 640 Tyr Lys Asp Leu Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asp Arg Glu Ser Gin Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 675 680 685 Page 2933 of 3790 Gly Arg Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu 690 695 700 Ser Phe Lys Ser Ile Ile Ser Lys Ala Gin Ser Gly Ser His Ser Asp 705 710 715 720 Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Tyr Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Asn Gin Gly Arg Arg Asn Ser Arg Gin Arg Tyr Lys Leu 770 775 780 Leu Glu Asp Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asp Ile 785 790 795 800 Leu Lys Glu Tyr Pro Thr Asp Asn Gin Ala Leu Gin Asn Glu Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 820 825 830 Leu Asp Ile Asp Asn Leu Ser Gin Tyr Asp Ile Asp His Ile Val Pro 835 840 845 Gin Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 850 855 860 Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Asp Ile 865 870 875 880 Val Lys Ala Arg Lys Ala Phe Trp Lys Lys Leu Leu Asp Ala Lys Leu 885 890 895 Ile Ser Gin Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 900 905 910 Leu Thr Pro Asp Asp Lys Ala Gly Phe Ile Gin Arg Gin Leu Val Glu 915 920 925 Thr Arg Gin Ile Thr Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Page 2935 of 3790 Glu Asp 1370 1174 1378 PRT Streptococcus agalactiae 1174 Page 2936 of 3790 Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ser Ile Ile Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 100 105 110 Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gin Glu Glu Lys Tyr Tyr 115 120 125 His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 130 135 140 Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Gin Lys Gin Tyr Gin Ala Phe Leu Glu Ile 180 185 190 Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gin Asn Val Asp 195 200 205 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Arg Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Page 2937 of 3790 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Ser Gin Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gin 370 375 380 Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Page 2938 of 3790 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gin Phe Leu Asn Arg Lys 530 535 540 Gin Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 545 550 555 560 Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 565 570 575 Gly Ile Ala Ile Lys Gly Ile Glu Lys Gin Phe Asn Ala Ser Leu Ser 580 585 590 Thr Tyr His Asp Leu Lys Lys Ile Leu Gly Lys Asp Phe Leu Asp Asn 595 600 605 Thr Asp Asn Glu Leu Ile Leu Glu Asp Ile Ile Gin Thr Leu Thr Leu 610 615 620 Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Asp Ile Tyr Lys Asp 625 630 635 640 Phe Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg His Tyr Thr 645 650 655 Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 660 665 670 Glu Asn Gin Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 675 680 685 Asn Arg Asn Phe Met Gin Leu Ile Lys Asp Ala Gly Leu Ser Phe Lys 690 695 700 Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 705 710 715 720 Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 725 730 735 Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 740 745 750 Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr Page 2939 of 3790 Page 2941 of 3790 1175 1370 PRT Streptococcus agalactiae Page 2942 of 3790 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 100 105 110 Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gin Glu Glu Lys Tyr Tyr 115 120 125 His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 130 135 140 Lys Lys Glu Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Gin Lys Gin Tyr Gin Ala Phe Leu Glu Ile 180 185 190 Phe Asp Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gin Asn Val Asp 195 200 205 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Arg Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gin Leu 325 330 335 Page 2943 of 3790 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gin Glu Ile Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Gly Ser Glu Tyr Leu Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Arg Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Phe Leu Ala Glu Gly Phe Lys Asp Phe Gin Phe Leu Asn Arg Lys 530 535 540 Gin Lys Glu Thr Ile Phe Asn Ser Leu Phe Lys Glu Lys Arg Lys Val 545 550 555 560 Thr Glu Lys Asp Ile Ile Ser Phe Leu Asn Lys Val Asp Gly Tyr Glu 565 570 575 Gly Ile Ala Ile Lys Gly Ile Glu Lys Gin Phe Asn Ala Ser Leu Ser Page 2945 of 3790 Glu Ile Val Trp Asp Lys Lys Lys His Phe Ala Thr Val Arg Lys 1070 1075 1080 Page 2946 of 3790 Page 2947 of 3790 Glu Asp 1370 1176 1377 PRT Streptococcus agalactiae Page 2948 of 3790 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Arg Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Gin Lys Gin Tyr Gin Ala Phe Leu Glu Ile 180 185 190 Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gin Asn Val Asp 195 200 205 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His His Glu Asp Leu Lys His Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Asn Tyr Arg Glu Val Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Leu Lys Leu Leu Thr Lys Gin 370 375 380 Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His Page 2950 of 3790 Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asn Lys 660 665 670 Glu Asn Gin Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ser Ala 675 680 685 Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Asp Leu Ser Phe Lys 690 695 700 Pro Ile Ile Asp Lys Ala Arg Thr Gly Ser His Ser Asp Asn Leu Lys 705 710 715 720 Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 725 730 735 Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 740 745 750 Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn Gin Thr Thr 755 760 765 Ala Lys Gly Leu Ser Arg Ser Arg Gin Arg Leu Thr Thr Leu Arg Glu 770 775 780 Ser Leu Ala Asn Leu Lys Ser Asn Ile Leu Glu Glu Lys Lys Pro Lys 785 790 795 800 Tyr Val Lys Asp Gin Val Glu Asn His His Leu Ser Asp Asp Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Lys Lys Ala 820 825 830 Leu Asp Ile Asp Asn Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro 835 840 845 Gin Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 850 855 860 Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile Glu Ile 865 870 875 880 Val Lys Ala Arg Lys Met Phe Trp Lys Asn Leu Leu Asp Ala Lys Leu 885 890 895 Met Ser Gin Arg Lys Tyr Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly 900 905 910 Page 2951 of 3790 Page 2952 of 3790 1177 Page 2953 of 3790 1370 PRT Streptococcus agalactiae misc_feature (117)..(117) Xaa can be any naturally occurring amino acid Page 2954 of 3790 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys Tyr 245 250 255 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gin Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gin Glu Ile Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Page 2955 of 3790 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 530 535 540 Lys Gin Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 545 550 555 560 Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 565 570 575 Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 595 600 605 Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gin Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 625 630 635 640 Tyr Lys Asp Leu Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asp Lys Glu Ser Gin Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 675 680 685 Gly Arg Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu 690 695 700 Ser Phe Lys Ser Ile Ile Ser Lys Ala Gin Ala Gly Ser His Ser Asp Page 2958 of 3790 Glu Asp 1370 1178 1370 PRT Streptococcus agalactiae 1178 Met Asn Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Tyr Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Page 2959 of 3790 Arg Val Leu Gly Asn Thr Asp Lys Glu Tyr Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Gly Gly Asn Thr Ala Ser Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Glu Asp Asp Lys Arg 100 105 110 Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gin Glu Glu Lys Asp Tyr 115 120 125 His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 130 135 140 Lys Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Gin Arg Gin Tyr Gin Ala Phe Leu Glu Ile 180 185 190 Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gin Asn Ile Asp 195 200 205 Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Page 2960 of 3790 Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gin Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gin Glu Ile Phe 340 345 350 Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile Page 2962 of 3790 Page 2963 of 3790 Page 2964 of 3790 Glu Asp 1370 1179 1370 PRT Streptococcus agalactiae Page 2965 of 3790 Gly Ser Lys Tyr Pro Ile Phe Ala Thr Met Gin Glu Glu Lys Asp Tyr 115 120 125 His Glu Lys Phe Pro Thr Ile Tyr His Leu Arg Lys Glu Leu Ala Asp 130 135 140 Lys Lys Glu Lys Ala Asn Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Gin Arg Gin Tyr Gin Ala Phe Leu Glu Ile 180 185 190 Phe Asp Thr Thr Phe Glu Asn Asn His Leu Leu Ser Gin Asn Ile Asp 195 200 205 Val Glu Gly Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Val Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gin Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gin Glu Ile Phe 340 345 350 Thr Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr Page 2966 of 3790 355 360 365 Asn Gin Gly Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Gly Ser Glu Tyr Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Leu Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Glu Leu Val Asp Lys Glu Ala Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 530 535 540 Lys Gin Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 545 550 555 560 Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 565 570 575 Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Asp Phe 595 600 605 Page 2967 of 3790 Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gin Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 625 630 635 640 Tyr Lys Asp Leu Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asp Lys Glu Ser Gin Lys Thr Ile Leu Asp Tyr Leu Ile Ser Asp 675 680 685 Gly Arg Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Gly Leu 690 695 700 Ser Phe Lys Pro Ile Ile Asp Lys Ala Gin Ala Gly Ser His Ser Asp 705 710 715 720 Asn Leu Lys Glu Val Val Gly Glu Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Tyr Glu Pro Glu Gin Val Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Asn Gin Gly Arg Arg Asn Thr Arg Gin Arg Tyr Lys Leu 770 775 780 Leu Glu Glu Gly Val Lys Asn Leu Ala Ser Asp Leu Asn Gly Asn Ile 785 790 795 800 Leu Lys Glu Tyr Pro Thr Asp Asn Gin Ala Leu Gin Asn Glu Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Ala 820 825 830 Leu Asp Ile Asp Asn Leu Ser Gin Tyr Asp Ile Asp His Ile Val Pro 835 840 845 Gin Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Val Ser 850 855 860 Page 2968 of 3790 Gin Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Ala His Gly Asn 1100 1105 1110 Page 2969 of 3790 Thr Ser Thr Lys Glu Val Leu Asn Ser Thr Leu Ile His Gin Ser Page 2970 of 3790 1340 1345 1350 Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Gly Lys Leu Gly 1355 1360 1365 Glu Asp 1370 1180 1370 PRT Streptococcus agalactiae misc_feature (9)..(9) Xaa can be any naturally occurring amino acid Page 2971 of 3790 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Asp Asp Ser Phe Asp 165 170 175 Val Arg Asn Thr Asp Ile Ser Lys Gin Tyr Gin Asp Phe Leu Glu Ile 180 185 190 Phe Asn Thr Thr Phe Glu Asn Asn Asp Leu Leu Ser Gin Asn Val Asp 195 200 205 Val Glu Ala Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp 210 215 220 Arg Ile Leu Ala Gin Tyr Pro Asn Gin Lys Ser Thr Gly Ile Phe Ala 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys Tyr 245 250 255 Phe Asn Leu Glu Asp Lys Thr Pro Leu Gin Phe Ala Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Phe Ala 275 280 285 Asp Leu Phe Ser Ala Ala Lys Lys Leu Tyr Asp Ser Val Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Ile Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Gin Arg Tyr Asp Glu His Arg Glu Asp Leu Lys Gin Leu 325 330 335 Lys Gin Phe Val Lys Ala Ser Leu Pro Glu Lys Tyr Gin Glu Ile Phe 340 345 350 Ala Asp Ser Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Glu Gly Lys Thr 355 360 365 Asn Gin Glu Ala Phe Tyr Lys Tyr Leu Ser Lys Leu Leu Thr Lys Gin 370 375 380 Glu Asp Ser Glu Asn Phe Leu Glu Lys Ile Lys Asn Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val His 405 410 415 Page 2972 of 3790 Leu Thr Glu Leu Lys Ala Ile Ile Arg Arg Gin Ser Glu Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Ile Gly Pro Leu Ala Arg Glu Lys Ser Asp Phe Ala 450 455 460 Trp Met Thr Arg Lys Thr Asp Asp Ser Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Asp Leu Val Asp Lys Glu Lys Ser Ala Glu Ala Phe Ile His Arg Met 485 490 495 Thr Asn Asn Asp Phe Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Ile Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Arg Tyr Lys Asn Glu Gin Gly Glu Thr Tyr Phe Phe Asp Ser Asn Ile 530 535 540 Lys Gin Glu Ile Phe Asp Gly Val Phe Lys Glu His Arg Lys Val Ser 545 550 555 560 Lys Lys Lys Leu Leu Asp Phe Leu Ala Lys Glu Tyr Glu Glu Phe Arg 565 570 575 Ile Val Asp Val Ile Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Glu Lys Ile Leu Asp Lys Asp Phe 595 600 605 Leu Asp Asn Pro Asp Asn Glu Ser Ile Leu Glu Asp Ile Val Gin Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Lys Arg Leu Glu Asn 625 630 635 640 Tyr Lys Asp Leu Phe Thr Glu Ser Gin Leu Lys Lys Leu Tyr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Page 2974 of 3790 Page 2975 of 3790 Glu Asp 1370 1181 1125 Page 2976 of 3790 PRT Streptococcus anginosus Page 2977 of 3790 Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Pro Glu Gin Lys Arg Gin Ile 290 295 300 Val Glu Tyr Ala Arg Thr Ala Lys Thr Leu Gly Thr Pro Thr Leu Leu 305 310 315 320 Lys Tyr Ile Ala Lys Leu Val Asp Gly Ser Ile Asp Asp Ile Lys Gly 325 330 335 Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Met His Thr Phe Asp Ala 340 345 350 Tyr Arg Lys Met Arg Thr Leu Asp Leu Val Asn Ile Asp Ala Leu Ser 355 360 365 Arg Glu Thr Leu Asp Asp Leu Ala His Ile Leu Thr Leu Asn Thr Glu 370 375 380 Ser Glu Gly Ile Leu Glu Ala Leu Asn Ser Lys Met Pro Ser Thr Phe 385 390 395 400 Thr Lys Glu Gin Ile Asp Glu Leu Ile Gin Phe Arg Lys Lys Asn Ser 405 410 415 Ala Val Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Asn 420 425 430 Glu Leu Ile Ser Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr Ile 435 440 445 Leu Thr Arg Leu Gly Lys Gin Arg Ser Arg Glu Ile Ser Lys Arg Thr 450 455 460 Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val 465 470 475 480 Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Ile Asn Glu Ala Thr Page 2979 of 3790 His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg Leu 740 745 750 Trp Lys Lys Gin Asn Asn Pro Leu Ile Ser Tyr Lys Glu Gly Gin Phe 755 760 765 Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Thr Asp Asp Glu Tyr 770 775 780 Lys Glu Leu Val Phe Arg Pro Pro Tyr Asp Tyr Phe Val Asp Thr Leu 785 790 795 800 Lys Ser Lys Ser Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp 805 810 815 Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Gly Thr Arg 820 825 830 Lys Ala Gin Leu Gly Lys Asp Lys Gin Glu Glu Thr Tyr Val Leu Gly 835 840 845 Lys Ile Lys Asp Ile Tyr Ser Gin Lys Gly Tyr Glu Asp Phe Ile Lys 850 855 860 Arg Tyr Asn Lys Asp Glu Thr Gin Phe Leu Ile Tyr His Lys Asp Pro 865 870 875 880 Gin Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr Pro Asp 885 890 895 Lys Glu Leu Asn Glu Lys Gly Lys Glu Ile Pro Cys Asn Pro Phe Glu 900 905 910 Lys Tyr Arg Gin Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly 915 920 925 Lys Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 930 935 940 Asn His Ile Asp Ile Thr Pro Val Asn Ser Gin Asn Gin Val Val Leu 945 950 955 960 Gin Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Pro Arg Thr 965 970 975 Ser Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Arg Phe Glu 980 985 990 Page 2980 of 3790 Lys Gly Ser Gly Ser Tyr Gly Ile 995 1000 Ser Pro Glu Lys Tyr Asn Lys Val Gly Asp Gin Pro Gin Leu Asn Phe Lys Lys Lys Phe 1115 1120 1125 1182 1386 PRT Streptococcus anginosus 1182 Met Asn Gin Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val 20 Ile Thr Asp Asp Tyr Lys Val 25 Pro Ala Lys 30 Lys Met Lys Val Leu Gly Asn 35 Thr Asp Lys 40 Gin Ser Ile Lys Lys Asn Leu Leu 45 Gly Ala Leu 50 Leu Phe Asp Ser Gly 55 Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Leu Arg 65 70 75 80 Page 2981 of 3790 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Met Gin Val Asp Glu Ser 85 90 95 Phe Phe Gin Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 115 120 125 His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 130 135 140 Ile Ser Gin Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gin Leu Lys Ala 165 170 175 Glu Asn Thr Asn Val Gin Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 180 185 190 Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 195 200 205 Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala His Tyr Pro Ala Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Phe Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Gin Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 275 280 285 Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Val Lys Arg Tyr Glu Glu His Gin Lys Asp Leu Lys Lys Phe Glu 325 330 335 Page 2982 of 3790 Asp Phe Ile Lys Val Asn Ala Leu Asp Gin Tyr Asn Ala Ile Phe Lys 340 345 350 Asp Lys Asn Lys Lys Gly Tyr Ala Gly Tyr Ile Glu Ser Gly Val Lys 355 360 365 Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Gin Ile Asn 370 375 380 Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met His Ala Ile Leu Arg Arg Gin Gly Glu His Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Gin Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 450 455 460 Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 465 470 475 480 Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 485 490 495 Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Asn Glu Gin Gly Glu Ala Lys Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 565 570 575 Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ser Ser Page 2984 of 3790 Glu Ile Ala Trp Asn Lys Gin Thr Asp Phe Lys Ile Val Arg Lys 1070 1075 1080 Page 2985 of 3790 Page 2986 of 3790 Gly Glu Asp 1385 1183 1396 PRT Streptococcus anginosus 1183 Page 2987 of 3790 Ser Lys Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 165 170 175 Glu Asn Thr Asp Val Gin Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 180 185 190 Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 195 200 205 Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 210 215 220 Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Gin Ala Asn Phe Lys Thr Asn Phe 245 250 255 Gin Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Gly Leu Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 275 280 285 Leu Phe Val Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 325 330 335 Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 340 345 350 Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 355 360 365 Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 370 375 380 Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Tyr Phe Leu Page 2989 of 3790 Glu Met Ile Arg Gin Arg Leu Gin Lys Tyr Ser Asp Ile Phe Thr Thr 645 650 655 Gin Gin Leu Lys Glu Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg 660 665 670 Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg Asn Lys Glu Asn Lys Lys 675 680 685 Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr Ala Asn Arg Asn Phe 690 695 700 Met Gin Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 705 710 715 720 Arg Ala Gin Ile Ile Gly Asp Val Asp Asp Ile Ala Asn Val Val His 725 730 735 Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser Val 740 745 750 Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Thr Asn 755 760 765 Ile Ile Ile Glu Met Ala Arg Glu Asn Gin Thr Thr Asp Lys Gly Arg 770 775 780 Arg Asn Ser Gin Gin Arg Leu Lys Leu Leu Gin Asp Ser Leu Lys Asn 785 790 795 800 Leu Asp Asn Pro Val Asn Ile Lys Asn Val Glu Asn Gin Gin Leu Gin 805 810 815 Asn Asp Arg Leu Phe Leu Tyr Tyr Ile Gin Asn Gly Lys Asp Met Tyr 820 825 830 Thr Gly Glu Thr Leu Asp Ile Asn Asn Leu Ser Gin Tyr Asp Ile Asp 835 840 845 His Ile Ile Pro Gin Ala Phe Ile Lys Asp Asn Ser Leu Asp Asn Arg 850 855 860 Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asp Val Pro 865 870 875 880 Ser Ile Glu Val Val His Glu Met Lys Ser Phe Trp Ser Lys Leu Leu 885 890 895 Page 2990 of 3790 Lys Pro Lys Pro Asp Ser Ser Glu Asn Leu Val Gly Ile Lys Arg 1130 1135 1140 Page 2991 of 3790 Leu Leu Lys Asp Ser Ile Leu Ile His Gin Ser Ile Thr Gly Leu 1370 Page 2992 of 3790 1375 1380 Tyr Glu Thr Arg Ile Asp Leu Ser Lys Leu Gly Glu Asp 1385 1390 1395 1184 1375 PRT Streptococcus canis Asn Gin Leu Phe Glu Glu Ser Pro Leu Asp Glu Ile Glu Val Asp Ala Page 2993 of 3790 195 200 205 Lys Gly Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Lys 210 215 220 Leu Ile Ala Val Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Ile Ile Ala Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Thr Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Glu Leu Leu Gly Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Ser Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Ser Asn Ser Glu Val Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Val Lys Arg Tyr Asp Glu His His Gin Asp Leu Ala Leu Leu Lys 325 330 335 Thr Leu Val Arg Gin Gin Phe Pro Glu Lys Tyr Ala Glu Ile Phe Lys 340 345 350 Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ile Gly Ile Lys 355 360 365 His Arg Lys Arg Thr Thr Lys Leu Ala Thr Gin Glu Glu Phe Tyr Lys 370 375 380 Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Ala Glu Glu Leu Leu 385 390 395 400 Ala Lys Leu Asn Arg Asp Asp Leu Leu Arg Lys Gin Arg Thr Phe Asp 405 410 415 Asn Gly Ser Ile Pro His 420 Gin Ile His 425 Leu Lys Glu Leu His 430 Ala Ile Leu Arg Arg Gin Glu Glu Phe Tyr Pro Phe Leu Lys Glu Asn Arg Glu 435 440 445 Page 2994 of 3790 Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 450 455 460 Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Leu Thr Arg Lys Ser Glu 465 470 475 480 Glu Ala Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 485 490 495 Ser Ala Gin Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Glu Gin Leu 500 505 510 Pro Asn Lys Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 515 520 525 Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Arg Met 530 535 540 Arg Lys Pro Glu Phe Leu Ser Gly Glu Gin Lys Lys Ala Ile Val Asp 545 550 555 560 Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gin Leu Lys Glu 565 570 575 Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ile Gly 580 585 590 Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 595 600 605 Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 610 615 620 Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 625 630 635 640 Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 645 650 655 Val Met Lys Gin Leu Lys Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 660 665 670 Ser Arg Lys Met Ile Asn Gly Ile Arg Asp Lys Gin Ser Gly Lys Thr 675 680 685 Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ser Asn Arg Asn Phe Met 690 695 700 Page 2995 of 3790 Gin Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Glu Ile Glu Lys 705 710 715 720 Ala Gin Val Ser Gly Gin Gly Asp Ser Leu His Glu Gin Ile Ala Asp 725 730 735 Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Thr Val Lys 740 745 750 Ile Val Asp Glu Leu Val Lys Val Met Gly His Lys Pro Glu Asn Ile 755 760 765 Val Ile Glu Met Ala Arg Glu Asn Gin Thr Thr Thr Lys Gly Leu Gin 770 775 780 Gin Ser Arg Glu Arg Lys Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 785 790 795 800 Glu Ser Gin Ile Leu Lys Glu Asn Pro Val Glu Asn Thr Gin Leu Gin 805 810 815 Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr 820 825 830 Val Asp Gin Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 835 840 845 His Ile Val Pro Gin Ser Phe Ile Lys Asp Asp Ser Ile Asp Asn Lys 850 855 860 Val Leu Thr Arg Ser Val Glu Asn Arg Gly Lys Ser Asp Asn Val Pro 865 870 875 880 Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gin Leu Leu 885 890 895 Asn Ala Lys Leu Ile Thr Gin Arg Lys Phe Asp Asn Leu Thr Lys Ala 900 905 910 Glu Arg Gly Gly Leu Ser Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg 915 920 925 Gin Leu Val 930 Glu Thr Arg Gin 935 Ile Thr Lys His Val 940 Ala Arg Ile Leu Asp Ser Arg Met Asn Thr Lys Arg Asp Lys Asn Asp Lys Pro Ile Arg 945 950 955 960 Page 2996 of 3790 Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 965 970 975 Lys Asp Phe Gin Leu Tyr Lys Val Arg Asp Ile Asn Asn Tyr His His 980 985 990 Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys 995 1000 1005 Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr Lys 1010 1015 1020 Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gin Glu Ile 1025 1030 1035 Gly Lys Ala Thr Ala Lys Arg Phe Phe Tyr Ser Asn Ile Met Asn 1040 1045 1050 Phe Phe Lys Thr Glu Val Lys Leu Ala Asn Gly Glu Ile Arg Lys 1055 1060 1065 Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Val Val Trp 1070 1075 1080 Asn Lys Glu Lys Asp Phe Ala Thr Val Arg Lys Val Leu Ala Met 1085 1090 1095 Pro Gin Val Asn Ile Val Lys Lys Thr Glu Val Gin Thr Gly Gly 1100 1105 1110 Phe Ser Lys Glu Ser Ile Leu Ser Lys Arg Glu Ser Ala Lys Leu 1115 1120 1125 Ile Pro Arg Lys Lys Gly Trp Asp Thr Arg Lys Tyr Gly Gly Phe 1130 1135 1140 Gly Ser Pro Thr Val Ala Tyr Ser Ile Leu Val Val Ala Lys Val 1145 1150 1155 Glu Lys Gly Lys Ala Lys Lys Leu Lys Ser Val Lys Val Leu Val 1160 1165 1170 Gly Ile Thr Ile Met Glu Lys Gly Ser Tyr Glu Lys Asp Pro Ile 1175 1180 1185 Gly Phe Leu Glu Ala Lys Gly Tyr Lys Asp Ile Lys Lys Glu Leu 1370 1375 1185 1345 PRT Streptococcus constellatus 1185 Met Gly Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met Page 2998 of 3790 25 30 Lys Val Leu Gly Asn Thr Asp Lys Gin Ser Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 65 70 75 80 Tyr Leu Gin Glu Ile Phe Thr Gly Glu Met Asn Lys Val Asp Glu Asn 85 90 95 Phe Phe Gin Arg Leu Asp Asp Ser Phe Leu Val Asp Glu Asp Lys Arg 100 105 110 Gly Glu His His Pro Ile Phe Gly Asn Ile Ala Ala Glu Val Lys Tyr 115 120 125 His Asp Asp Phe Pro Thr Ile Tyr His Leu Arg Arg His Leu Ala Asp 130 135 140 Thr Ser Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Tyr Glu Gly Asp Leu Lys Ala 165 170 175 Glu Asn Thr Asp Val Gin Ala Leu Phe Lys Asp Phe Val Glu Glu Tyr 180 185 190 Asp Lys Thr Ile Glu Glu Ser His Leu Ser Glu Ile Thr Val Asp Ala 195 200 205 Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Ser Arg Leu Glu Asn 210 215 220 Leu Ile Ala His Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Asp Leu His Pro Asn Phe Lys Thr Asn Phe 245 250 255 Gin Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Page 2999 of 3790 Glu Asp Leu Glu Gly Phe Leu Gly Glu Val Gly Asp Glu Tyr Ala Asp 275 280 285 Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Val Lys Arg Tyr Glu Glu His Gin Lys Asp Leu Lys Lys Leu Lys 325 330 335 Asp Phe Ile Lys Val Asn Ala Pro Asp Gin Tyr Asn Ala Ile Phe Lys 340 345 350 Asp Lys Asn Lys Lys Gly Tyr Ala Ser Tyr Ile Glu Ser Gly Val Lys 355 360 365 Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Gly Ile Leu Leu Lys Ile Asn 370 375 380 Gly Ser Gly Asp Phe Leu Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met His Ala Ile Leu Arg Arg Gin Gly Glu His Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Gin Asp Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Gly Ser Arg Phe Ala Trp 450 455 460 Ala Glu Tyr Lys Ala Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp 465 470 475 480 Ile Leu Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 485 490 495 Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Pro Leu Tyr Glu Ala Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Page 3000 of 3790 Tyr Val Asn Glu Gin Gly Glu Ala Lys Phe Phe Asp Thr Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile 565 570 575 Val Asn Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ser Ser 580 585 590 Leu Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Ser Phe Leu 595 600 605 Asp Asp Lys Ala Asn Glu Lys Thr Ile Glu Asp Ile Ile Gin Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Gin Arg Leu Gin Lys Tyr 625 630 635 640 Ser Asp Ile Phe Thr Lys Ala Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 660 665 670 Asn Lys Glu Asn Lys Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Tyr Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Arg Ala Gin Ile Ile Asp Asp Val Asp Asp 705 710 715 720 Ile Ala Asn Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 740 745 750 Gly His Asn Pro Ala Asn Ile Ile Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Asp Lys Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Leu Leu 770 775 780 Page 3001 of 3790 Ala Thr Glu Lys Phe Leu Phe Tyr Ser Asn Ile Leu Arg Phe Phe Page 3003 of 3790 1340 1345 1186 538 PRT Streptococcus dysgalactiae Page 3004 of 3790 Val Ser Asp Phe Arg Lys Asp Phe Gin Phe Tyr Lys Val Arg Glu Ile 130 135 140 Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly 145 150 155 160 Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr 165 170 175 Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu 180 185 190 Gin Glu Ile Gly Lys Ala Thr Ala Lys Arg Phe Phe Tyr Ser Asn Ile 195 200 205 Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg 210 215 220 Lys Arg Pro Leu Ile Glu Thr Asn Glu Glu Thr Gly Glu Ile Val Trp 225 230 235 240 Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro 245 250 255 Gin Val Asn Ile Val Lys Lys Thr Glu Val Gin Thr Gly Ala Leu Thr 260 265 270 Asn Glu Ser Ile Tyr Ala Arg Gly Ser Phe Asp Lys Leu Ile Ser Arg 275 280 285 Lys His Arg Phe Glu Ser Ser Lys Tyr Gly Gly Phe Gly Ser Pro Thr 290 295 300 Val Thr Tyr Ser Val Leu Val Val Ala Lys Ser Lys Val Gin Asp Gly 305 310 315 320 Lys Val Lys Lys Ile Lys Thr Gly Lys Glu Leu Ile Gly Ile Thr Leu 325 330 335 Leu Asp Lys Leu Val Phe Glu Lys Asn Pro Leu Lys Phe Ile Glu Asp 340 345 350 Lys Gly Tyr Gly Asn Val Gin Ile Asp Lys Cys Ile Arg Leu Pro Lys 355 360 365 Tyr Ser Leu Phe Glu Phe Glu Asn Gly Thr Arg Arg Met Leu Ala Ser 370 375 380 Page 3005 of 3790 Page 3006 of 3790 Lys Arg Ser Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Page 3007 of 3790 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gin 530 535 540 Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gin 805 810 815 Page 3009 of 3790 Page 3010 of 3790 1188 1371 PRT Streptococcus dysgalactiae Page 3011 of 3790 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Met Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Page 3012 of 3790 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gin 530 535 540 Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala Page 3014 of 3790 Ser Phe Asp Lys Leu Ile Ser Arg Lys His Arg Phe Glu Ser Ser 1115 1120 1125 Page 3015 of 3790 Page 3016 of 3790 Gly Gly Asp 1370 1189 1371 PRT Streptococcus dysgalactiae Page 3017 of 3790 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Arg Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Page 3019 of 3790 Lys Glu Ala Ile Gin Lys Ala Gin Val Ser Gly Gin Gly His Ser Leu 705 710 715 720 His Glu Gin Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr 755 760 765 Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 770 775 780 Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro Val 785 790 795 800 Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gin 805 810 815 Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg Leu 820 825 830 Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Ile Lys Asp 835 840 845 Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 850 855 860 Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 865 870 875 880 Tyr Trp Arg Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys Phe 885 890 895 Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 900 905 910 Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys 915 920 925 His Val Ala Gin Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 930 935 940 Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 945 950 955 960 Page 3020 of 3790 Page 3021 of 3790 Gly Gly Asp 1370 1190 1371 PRT Streptococcus dysgalactiae 1190 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Page 3022 of 3790 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Arg 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Ser Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Lys Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Lys Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asn Gin Tyr Ala Asp Page 3023 of 3790 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Page 3024 of 3790 Tyr Val Thr Glu Gly Met Arg Lys Pro Glu Phe Leu Ser Gly Lys Gin 530 535 540 Lys Glu Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Lys Glu Met Ile Glu Glu Arg Leu Lys Lys Tyr Ala 625 630 635 640 Asn Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg His Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Ala Ile Gin Lys Ala Gin Val Ser Gly Gin Gly His Ser Leu 705 710 715 720 His Glu Gin Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Ser Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr 755 760 765 Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 770 775 780 Page 3025 of 3790 Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val 995 1000 1005 Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys 1010 1015 1020 Ser Glu Gin Glu Ile Gly Lys Ala Thr Ala Lys Arg Phe Phe Tyr 1025 1030 1035 Page 3026 of 3790 Asp His Tyr Asn Asp Leu Tyr Gin Leu Leu Ser Tyr Ile Glu Arg Gly Gly Asp 1370 1191 1370 PRT Streptococcus gallolyticus Ser Phe Phe Tyr Arg Leu Asp Glu Ser Phe Leu Thr Thr Asp Glu Lys 325 330 335 Lys Glu Phe Ile Lys Ala Asn Lys Ser Glu Leu Tyr His Asp Ile Phe 340 345 350 Page 3029 of 3790 Lys Asp Lys Asn Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val 355 360 365 Lys Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile 370 375 380 Asp Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Leu Gin Glu Met His Ala Ile Leu Arg Arg Gin Gly Asp Tyr Tyr Pro 420 425 430 Phe Leu Lys Glu Lys Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Val Arg Lys Asp Ser Arg Phe Ala 450 455 460 Trp Ala Glu Tyr Arg Ser Asp Glu Lys Ile Thr Pro Trp Asn Phe Asp 465 470 475 480 Lys Val Ile Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met 485 490 495 Thr Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser His Val Tyr Glu Thr Tyr Ala Val Tyr Asn Glu Leu Thr Lys Ile 515 520 525 Lys Tyr Val Asn Glu Gin Gly Lys Glu Ser Phe Phe Asp Ser Asn Met 530 535 540 Lys Gin Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr 545 550 555 560 Lys Glu Lys Leu Leu Asn Tyr Leu Asn Lys Glu Phe Pro Glu Tyr Arg 565 570 575 Ile Lys Asp Leu Ile Gly Leu Asp Lys Glu Asn Lys Ser Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ala Phe 595 600 605 Page 3030 of 3790 Leu Asp Asp Lys Val Asn Glu Glu Val Ile Glu Asp Ile Ile Lys Thr 610 615 620 Leu Thr Leu Phe Glu Asp Lys Asp Met Ile His Glu Arg Leu Gin Lys 625 630 635 640 Tyr Ser Asp Ile Phe Thr Ala Asn Gin Leu Lys Lys Leu Glu Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 675 680 685 Gly Ser Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Thr Leu 690 695 700 Pro Phe Lys Gin Ile Ile Gin Lys Ser Gin Val Val Gly Asp Val Asp 705 710 715 720 Asp Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Val Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Asn Arg Gly Arg Ser Gin Ser Gin Gin Arg Leu Lys Lys 770 775 780 Leu Gin Ser Ser Leu Lys Glu Leu Gly Ser Asn Ile Leu Asn Glu Glu 785 790 795 800 Lys Pro Ser Tyr Ile Glu Asp Lys Val Glu Asn Ser His Leu Gin Asn 805 810 815 Asp Gin Leu Phe Leu Tyr Tyr Ile Gin Asn Gly Lys Asp Met Tyr Thr 820 825 830 Gly Asp Glu Leu Asp Ile Asp His Leu Ser Asp Tyr Asp Ile Asp His 835 840 845 Ile Ile Pro Gin Ala Phe Ile Lys Asp Asp Ser Ile Asp Asn Arg Val 850 855 860 Page 3031 of 3790 Val Lys Lys Val Glu Thr Gin Thr Gly Gly Phe Ser Lys Glu Ser Page 3033 of 3790 Thr Ser Thr Lys Glu Cys Leu Thr Ala Thr Leu Ile His Gin Ser 1340 1345 1350 Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Lys Leu Gly 1355 1360 1365 Glu Glu 1370 1192 1375 PRT Streptococcus infantarius 1192 Page 3034 of 3790 Glu Asn Thr Asp Val Gin Lys Leu Phe Asn Val Phe Val Glu Thr Tyr 180 185 190 Asp Lys Ile Val Asp Glu Ser His Leu Ser Glu Ile Glu Val Asp Ala 195 200 205 Ser Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Lys Gin Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ala Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Val Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Ile Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Asp Asp Asn Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Val Glu His His Glu Asp Leu Glu Lys Leu Lys 325 330 335 Glu Phe Ile Lys Ile Asn Lys Leu Lys Leu Tyr His Asp Ile Phe Lys 340 345 350 Asp Lys Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Asn Gly Val Lys 355 360 365 Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Thr Ile Leu Thr Lys Ile Asp 370 375 380 Asp Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Asp Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met His Ser Ile Leu Arg Arg Gin Gly Asp Tyr Tyr Pro Phe 420 425 430 Page 3035 of 3790 Leu Lys Glu Asn Gin Ala Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asp Ser Arg Phe Ala Trp 450 455 460 Ala Asn Tyr His Ser Asp Glu Pro Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Val Val Asp Lys Glu Lys Ser Ala Glu Lys Phe Ile Thr Arg Met Thr 485 490 495 Leu Asn Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 His Val Tyr Glu Thr Phe Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 515 520 525 Tyr Val Asn Glu Gin Gly Glu Ser Phe Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp His Val Phe Lys Glu Asn Arg Lys Val Thr Lys 545 550 555 560 Ala Lys Leu Leu Ser Tyr Leu Asn Asn Glu Phe Glu Glu Phe Arg Ile 565 570 575 Asn Asp Leu Ile Gly Leu Asp Lys Asp Ser Lys Ser Phe Asn Ala Ser 580 585 590 Leu Gly Thr Tyr His Asp Leu Lys Lys Ile Leu Asp Lys Ser Phe Leu 595 600 605 Asp Asp Lys Thr Asn Gly Gin Ile Ile Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Asp Met Ile His Glu Arg Leu Gin Lys Tyr 625 630 635 640 Ser Asp Phe Phe Thr Ser Gin Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Tyr Lys Leu Ile Asn Gly Ile Arg 660 665 670 Asn Lys Glu Asn Asn Lys Thr Ile Leu Asp Phe Leu Ile Asp Asp Gly 675 680 685 Page 3036 of 3790 His Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Glu Ser Leu Ser 690 695 700 Phe Lys Thr Ile Ile Gin Glu Ala Gin Val Val Gly Asp Val Asp Asp 705 710 715 720 Ile Glu Ala Val Val His Asp Leu Pro Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Val Lys Ile Val Asp Glu Leu Val Lys Val Met 740 745 750 Gly Asp Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gly Tyr Gly Arg Asn Lys Ser Asn Gin Arg Leu Lys Arg Leu 770 775 780 Gin Asp Ser Leu Lys Glu Phe Gly Ser Asp Ile Leu Ser Lys Lys Lys 785 790 795 800 Pro Ser Tyr Val Asp Ser Lys Val Glu Asn Ser His Leu Gin Asn Asp 805 810 815 Arg Leu Phe Leu Tyr Tyr Ile Gin Asn Gly Lys Asp Met Tyr Thr Gly 820 825 830 Glu Glu Leu Asp Ile Asp Arg Leu Ser Asp Tyr Asp Ile Asp His Ile 835 840 845 Ile Pro Gin Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 850 855 860 Thr Ser Ser Ala Lys Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Ile 865 870 875 880 Glu Ile Val Arg Asn Arg Arg Ser Tyr Trp Tyr Lys Leu Tyr Lys Ser 885 890 895 Gly Leu Ile Ser Lys Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 900 905 910 Gly Gly Leu Thr Glu Ala Asp Lys Ala Gly Phe Ile Lys Arg Gin Leu 915 920 925 Val Glu Thr Arg Gin Ile Thr Lys His Val Ala Gin Ile Leu Asp Ala 930 Page 3037 of 3790 935 940 Arg Phe Asn Thr Lys Arg Asp Glu Asn Asp Lys Val Ile Arg Asp Val 945 950 955 960 Lys Val Ile Thr Leu Lys Ser Asn Leu Val Ser Gin Phe Arg Lys Glu 965 970 975 Phe Lys Phe Tyr Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His 980 985 990 Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Leu Lys Lys Tyr 995 1000 1005 Pro Lys Leu Thr Pro Glu Phe Val Tyr Gly Glu Tyr Lys Lys Tyr 1010 1015 1020 Asp Val Arg Lys Leu Ile Ala Lys Ser Ser Asp Asp Tyr Ser Glu 1025 1030 1035 Met Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Leu Met 1040 1045 1050 Asn Phe Phe Lys Thr Glu Val Lys Tyr Ala Asp Gly Arg Val Phe 1055 1060 1065 Glu Arg Pro Asp Ile Glu Thr Asn Ala Asp Gly Glu Val Val Trp 1070 1075 1080 Asn Lys Gin Lys Asp Phe Asp Ile Val Arg Lys Val Leu Ser Tyr 1085 1090 1095 Pro Gin Val Asn Ile Val Lys Lys Val Glu Ala Gin Thr Gly Gly 1100 1105 1110 Phe Ser Lys Glu Ser Ile Leu Ser Lys Gly Asp Ser Asp Lys Leu 1115 1120 1125 Ile Pro Arg Lys Thr Lys Lys Val Tyr Trp Asn Thr Lys Lys Tyr 1130 1135 1140 Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val 1145 1150 1155 Ala Asp Ile Glu Lys Gly Lys Ala Lys Lys Leu Lys Thr Val Lys 1160 1165 1170 Page 3038 of 3790 1370 1375 1193 1368 PRT Streptococcus iniae 1193 Page 3039 of 3790 Met Arg Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 20 25 30 Arg Ile Gin Gly Thr Thr Asp Arg Thr Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Asn Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Lys Tyr Arg Ile Lys 65 70 75 80 Glu Leu Gin Lys Ile Phe Ser Ser Glu Met Asn Glu Leu Asp Ile Ala 85 90 95 Phe Phe Pro Arg Leu Ser Glu Ser Phe Leu Val Ser Asp Asp Lys Glu 100 105 110 Phe Glu Asn His Pro Ile Phe Gly Asn Leu Lys Asp Glu Ile Thr Tyr 115 120 125 His Asn Asp Tyr Pro Thr Ile Tyr His Leu Arg Gin Thr Leu Ala Asp 130 135 140 Ser Asp Gin Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asn Leu Asp Ser 165 170 175 Glu Asn Thr Asp Val His Val Leu Phe Leu Asn Leu Val Asn Ile Tyr 180 185 190 Asn Asn Leu Phe Glu Glu Asp Ile Val Glu Thr Ala Ser Ile Asp Ala 195 200 205 Glu Lys Ile Leu Thr Ser Lys Thr Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Glu Ile Pro Asn Gin Lys Arg Asn Met Leu Phe Gly Asn 225 230 235 240 Leu Val Ser Leu Ala Leu Gly Leu Thr Pro Asn Phe Lys Thr Asn Phe 245 250 255 Page 3040 of 3790 Glu Leu Leu Glu Asp Ala Lys Leu Gin Ile Ser Lys Asp Ser Tyr Glu 260 265 270 Glu Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Ile Ala Ala Lys Lys Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Ile Thr Val Lys Gly Ala Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Val Gin Arg Tyr Glu Glu His Gin Gin Asp Leu Ala Leu Leu Lys 325 330 335 Asn Leu Val Lys Lys Gin Ile Pro Glu Lys Tyr Lys Glu Ile Phe Asp 340 345 350 Asn Lys Glu Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Tyr Ile Lys Pro Ile Leu Leu Lys Leu Asp 370 375 380 Gly Thr Glu Lys Leu Ile Ser Lys Leu Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Asn Glu Leu Lys Ala Ile Ile Arg Arg Gin Glu Lys Phe Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Gin Lys Lys Ile Glu Lys Leu Phe Thr Phe Lys Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Asn Gly Gin Ser Ser Phe Ala Trp 450 455 460 Leu Lys Arg Gin Ser Asn Glu Ser Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Gin Glu Ala Ser Ala Arg Ala Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Page 3041 of 3790 Pro Leu Tyr Glu Met Phe Met Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Gin Thr Glu Gly Met Lys Arg Pro Val Phe Leu Ser Ser Glu Asp 530 535 540 Lys Glu Glu Ile Val Asn Leu Leu Phe Lys Lys Glu Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Glu Tyr Phe Ser Lys Met Lys Cys Phe His 565 570 575 Thr Val Thr Ile Leu Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Phe Lys Asp Lys Ala Phe Leu Asp 595 600 605 Asp Glu Ala Asn Gin Asp Ile Leu Glu Glu Ile Val Trp Thr Leu Thr 610 615 620 Leu Phe Glu Asp Gin Ala Met Ile Glu Arg Arg Leu Val Lys Tyr Ala 625 630 635 640 Asp Val Phe Glu Lys Ser Val Leu Lys Lys Leu Lys Lys Arg His Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Gin Lys Leu Ile Asn Gly Ile Lys Asp 660 665 670 Lys Gin Thr Gly Lys Thr Ile Leu Gly Phe Leu Lys Asp Asp Gly Val 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Ser Ser Leu Asp Phe 690 695 700 Ala Lys Ile Ile Lys Asn Glu Gin Glu Lys Thr Ile Lys Asn Glu Ser 705 710 715 720 Leu Glu Glu Thr Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Ile Val Lys Ile Met 740 745 750 Gly Gin Asn Pro Asp Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin Page 3042 of 3790 Page 3044 of 3790 1194 1392 PRT Streptococcus mitis Page 3045 of 3790 Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys 100 105 110 Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ala Glu Glu Lys Glu 115 120 125 Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 130 135 140 Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 145 150 155 160 His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 165 170 175 Ile Lys Asn Asn Asp Ile Gin Lys Ile Phe Ser Glu Phe Ile Ser Ile 180 185 190 Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gin Asn Ala Gin 195 200 205 Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 210 215 220 Arg Ile Leu Lys Leu Phe Ala Tyr Glu Lys Ser Thr Asp Leu Phe Ser 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asp Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Asp Phe Ala 275 280 285 Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Glu Arg Tyr Glu Asn His Gin Lys Asp Leu Ala Ala Leu 325 330 335 Lys Gin Phe Ile Gin Asn Asn Leu Gin Glu Lys Tyr Asp Glu Val Phe 340 345 350 Page 3046 of 3790 Ser Asp Gin Ser Lys Asp Gly Tyr Ala Arg Tyr Ile Asn Gly Lys Thr 355 360 365 Thr Gin Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 370 375 380 Glu Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Leu Gin Glu Met Asn Ala Ile Ile Arg Arg Gin Gly Glu His Tyr Pro 420 425 430 Phe Leu Lys Glu Tyr Lys Glu Lys Ile Glu Thr Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asn Phe Ala 450 455 460 Trp Leu Thr Arg Asn Ser Asp Gin Ala Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Glu Ile Val Asp Gin Ala Ser Ser Ala Glu Glu Phe Ile Asn Lys Met 485 490 495 Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Lys Phe Ile Ser Glu Gly Leu Arg Asp Tyr Gin Phe Leu Asp Ser Gly 530 535 540 Gin Lys Lys Gin Ile Val Asn Gin Leu Phe Lys Glu Lys Arg Lys Val 545 550 555 560 Thr Glu Lys Asp Ile Ile Gin Tyr Leu His Asn Val Asp Gly Tyr Asp 565 570 575 Gly Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ala Ser Leu Ser 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Page 3047 of 3790 595 600 605 Asp Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr 610 615 620 Ile Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Gin Tyr Ala 625 630 635 640 Ser Ile Phe Asp Lys Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr 645 650 655 Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Cys Asp 660 665 670 Lys Lys Thr Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Tyr 675 680 685 Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu Ser Phe 690 695 700 Lys Asp Ile Ile Gin Lys Ala Gin Val Val Gly Lys Thr Asn Asp Val 705 710 715 720 Lys Gin Val Val Gin Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 His Ala Pro Glu Ser Ile Val Ile Glu Ile Ala Arg Glu Asn Gin Thr 755 760 765 Thr Ala Arg Gly Lys Lys Asn Ser Gin Gin Arg Tyr Lys Arg Ile Glu 770 775 780 Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys 785 790 795 800 Glu His Pro Thr Asp Asn Ile Gin Leu Gin Asn Asp Arg Leu Phe Leu 805 810 815 Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 820 825 830 Ile Asn Gin Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gin Ala 835 840 845 Page 3048 of 3790 Page 3049 of 3790 Page 3050 of 3790 1195 1134 PRT Streptococcus mutans 1195 Page 3051 of 3790 Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 165 170 175 Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 180 185 190 Glu Ala Glu Arg Ile Leu Arg Arg Gin Gin Glu Phe Asn Met Arg Ile 195 200 205 Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 210 215 220 Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 225 230 235 240 Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 245 250 255 Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 260 265 270 Ser Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 275 280 285 Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Arg Gin 290 295 300 Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 305 310 315 320 Leu Lys Tyr Ile Val Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 325 330 335 Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 340 345 350 Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Asp Asp Leu 355 360 365 Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 370 375 380 Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 385 390 395 400 Glu Phe Asn Gin Glu Gin Ile Asn Glu Leu Val Leu Phe Arg Lys Asn Ala Trp Thr Tyr Arg Glu Phe Lys Ser Tyr Val Lys Gly Leu Lys Thr 645 650 655 Page 3053 of 3790 Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asn Ile Asp 660 665 670 Lys Ile Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 675 680 685 Arg Tyr Ser Ser Arg Val Val Leu Asn Ala Leu Gin Asp Phe Tyr Lys 690 695 700 Glu Arg Lys Phe Asp Thr Lys Ile Ser Val Val Arg Gly Gin Phe Thr 705 710 715 720 Ser Gin Leu Arg Arg Lys Trp Arg Ile Glu Lys Thr Arg Glu Thr Tyr 725 730 735 His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu 740 745 750 Asn Leu Trp Lys Lys Gin Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 755 760 765 Gin Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 770 775 780 Glu Tyr Lys Lys Leu Val Phe Lys Ala Pro Tyr Glu His Phe Val Asp 785 790 795 800 Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin 805 810 815 Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Gly Ala Thr Ile Cys Gly 820 825 830 Thr Arg Lys Ala Gin Leu Gly Lys Asp Thr Gin Glu Glu Thr Tyr Val 835 840 845 Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gin Lys Gly Tyr Glu Asp Phe 850 855 860 Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gin Phe Leu Met Tyr His Lys 865 870 875 880 Asp Pro Gin Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 885 890 895 Pro Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Ser Cys Asn Pro 900 905 910 Page 3054 of 3790 1130 1196 1134 Page 3055 of 3790 PRT Streptococcus mutans Page 3056 of 3790 Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 245 250 255 Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 260 265 270 Ser Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 275 280 285 Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Arg Gin 290 295 300 Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 305 310 315 320 Leu Lys Tyr Ile Val Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 325 330 335 Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 340 345 350 Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Asp Asp Leu 355 360 365 Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 370 375 380 Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 385 390 395 400 Glu Phe Asn Gin Glu Gin Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 405 410 415 Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 420 425 430 Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met 435 440 445 Thr Ile Leu Thr Arg Leu Gly Lys Gin Arg Val Lys Lys Ser Ser Asn 450 455 460 Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 465 470 475 480 Pro Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Ile Asn Leu Page 3058 of 3790 His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu 740 745 750 Asn Leu Trp Lys Lys Gin Asn Asn Pro Leu Ile Ser Tyr Lys Glu Asp 755 760 765 Gin Phe Val Asp Pro Glu Thr Gly Glu Ile Leu Ser Leu Ser Asp Asp 770 775 780 Glu Tyr Lys Lys Leu Val Phe Lys Ala Pro Tyr Glu His Phe Val Asp 785 790 795 800 Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin 805 810 815 Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Gly Ala Thr Ile Cys Gly 820 825 830 Thr Arg Lys Ala Gin Leu Gly Lys Asp Thr Gin Glu Glu Thr Tyr Val 835 840 845 Leu Gly Lys Ile Lys Asp Ile Tyr Ser Gin Lys Gly Tyr Glu Asp Phe 850 855 860 Ile Lys Lys Tyr Lys Lys Asp Lys Thr Gin Phe Leu Met Tyr His Lys 865 870 875 880 Asp Pro Gin Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Lys Thr Tyr 885 890 895 Pro Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Ser Cys Asn Pro 900 905 910 Phe Glu Lys Tyr Arg Gin Glu Asn Gly Pro Val Arg Lys Tyr Ser Lys 915 920 925 Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Glu Val 930 935 940 Leu Gly Lys Asn Ile Asp Ile Thr Pro Lys Asn Ser Leu Asn Lys Val 945 950 955 960 Val Leu Arg Ser Leu Asn Pro Trp Arg Thr Asp Val Tyr Phe Asn His 965 970 975 Glu Thr Arg Lys Tyr Glu Phe Leu Gly Leu Lys Tyr Ser Asp Leu Arg 980 985 990 Page 3059 of 3790 Tyr Leu Lys Gly Glu His Arg Tyr Gly Ile Leu Ile Gly Asp Tyr Lys 995 1000 1005 1130 1197 1128 PRT Streptococcus mutans Page 3060 of 3790 Val Arg Leu Ala Asp Leu Phe Leu Asp Ser Asn Leu Leu Thr Asp Phe 65 70 75 80 Ser Lys Val Ser Leu Asn Leu Asn Pro Tyr Gin Leu Arg Val Lys Gly 85 90 95 Leu Asn Glu Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Ser 100 105 110 Ile Val Ser Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp 115 120 125 Ser Gly Ala Asn Ser Ser Glu Tyr Gly Lys Ala Val Glu Glu Asn Arg 130 135 140 Lys Leu Leu Glu Asp Arg Thr Pro Gly Gin Ile Gin Leu Glu Arg Phe 145 150 155 160 Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 165 170 175 Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 180 185 190 Glu Ala Glu Arg Ile Leu Arg Arg Gin Gin Glu Phe Asn Ile Arg Ile 195 200 205 Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 210 215 220 Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 225 230 235 240 Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 245 250 255 Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 260 265 270 Ser Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 275 280 285 Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Arg Gin 290 295 300 Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 305 310 315 320 Page 3061 of 3790 Leu Lys Tyr Ile Ala Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 325 330 335 Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 340 345 350 Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Ala Asp Leu 355 360 365 Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 370 375 380 Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 385 390 395 400 Glu Phe Asn Gin Glu Gin Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 405 410 415 Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 420 425 430 Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met 435 440 445 Thr Ile Leu Thr Arg Leu Gly Lys Gin Arg Val Lys Lys Ser Ser Asn 450 455 460 Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 465 470 475 480 Pro Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Ile Asn Leu 485 490 495 Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 500 505 510 Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Asn Ala Gin 515 520 525 Lys Ala Asn Glu Asp Glu Lys Glu Ala Ala Leu Leu Lys Ala Ala His 530 535 540 Gin Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 545 550 555 560 Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Lys Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin 805 810 815 Page 3063 of 3790 Page 3064 of 3790 1198 1128 PRT Streptococcus mutans Page 3065 of 3790 Glu Lys Tyr Gly Lys Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly 165 170 175 Glu Asn His Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys 180 185 190 Glu Ala Glu Arg Ile Leu Arg Arg Gin Gin Glu Phe Asn Ile Arg Ile 195 200 205 Ala Asp Glu Phe Ile Glu Ala Tyr Leu Thr Ile Leu Thr Gly Lys Arg 210 215 220 Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 225 230 235 240 Arg Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu 245 250 255 Ile Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ala Lys Ala 260 265 270 Ser Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 275 280 285 Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Arg Gin 290 295 300 Ile Ile Glu His Ala Lys Thr Val Lys Thr Leu Gly Ala Pro Thr Leu 305 310 315 320 Leu Lys Tyr Ile Ala Lys Leu Val Gly Cys Ser Ala Asp Asp Ile Lys 325 330 335 Gly Tyr Arg Ile Asp Lys Ser Asp Lys Pro Glu Ile His Thr Phe Glu 340 345 350 Ala Tyr Arg Lys Met Arg Thr Met Glu Leu Ile Lys Val Ala Asp Leu 355 360 365 Ser Arg Glu Ser Leu Asp Ala Leu Ala His Ile Leu Thr Leu Asn Thr 370 375 380 Glu Arg Glu Gly Ile Glu Glu Ala Ile Arg Asp Arg Phe Thr Asn Lys 385 390 395 400 Glu Phe Asn Gin Glu Gin Ile Asn Glu Leu Val Leu Phe Arg Lys Asn 405 410 415 Page 3066 of 3790 Asn Ser Ser Leu Phe Gly Lys Gly Trp His Asn Phe Ser Leu Lys Leu 420 425 430 Met Lys Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met 435 440 445 Thr Ile Leu Thr Arg Leu Gly Lys Gin Arg Val Lys Lys Ser Ser Asn 450 455 460 Arg Thr Asn Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn 465 470 475 480 Pro Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Ile Asn Leu 485 490 495 Ala Thr Lys Lys Tyr Gly Val Phe Asp Asn Ile Val Ile Glu Met Ala 500 505 510 Arg Glu Ser Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Asn Ala Gin 515 520 525 Lys Ala Asn Glu Asp Glu Lys Glu Ala Ala Leu Leu Lys Ala Ala His 530 535 540 Gin Phe Asn Gly Lys Glu Glu Leu Pro Asp Ser Ile Phe His Gly His 545 550 555 560 Lys Glu Leu Leu Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Lys 565 570 575 Cys Leu Tyr Thr Gly Lys Thr Ile Phe Ile Asn Asp Leu Ile His Asn 580 585 590 Pro Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe 595 600 605 Asp Asp Ser Leu Ala Asn Lys Val Leu Val Leu Ser Thr Ala Asn Gin 610 615 620 Glu Lys Gly Gin Arg Thr Pro Phe Gin Ser Leu Asp Ser Met Asp Gly 625 630 635 640 Ala Trp Thr Tyr Arg Glu Phe Lys Ala Tyr Val Lys Gly Leu Lys Thr 645 650 655 Leu Ser Asn Lys Lys Lys Asp Tyr Leu Leu Asn Glu Glu Asp Ile Asn 885 890 895 Ser Asp Lys Glu Leu Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro 900 905 910 Page 3068 of 3790 1199 1338 PRT Streptococcus mutans 1199 Page 3069 of 3790 Met Asp Leu Ile Gly Thr Asn Ser Val Gly Trp Ala Val Val Thr Asp 15 10 15 Asp Tyr Lys Val Pro Ala Lys Lys Met Lys Val Leu Gly Asn Thr Asp 20 25 30 Lys Ser His Ile Lys Lys Asn Leu Leu Gly Ala Leu Leu Phe Asp Ser 35 40 45 Gly Asn Thr Ala Ala Asp Arg Arg Leu Lys Arg Thr Ala Arg Arg Arg 50 55 60 Tyr Thr Arg Arg Arg Asn Arg Ile Leu Tyr Leu Gin Glu Ile Phe Ala 65 70 75 80 Glu Glu Met Ser Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Asp 85 90 95 Ser Phe Leu Val Thr Glu Asp Lys Arg Gly Glu Arg His Pro Ile Phe 100 105 110 Gly Asn Leu Glu Glu Glu Val Lys Tyr His Glu Asn Phe Pro Thr Ile 115 120 125 Tyr His Leu Arg Gin Tyr Leu Ala Asp Asn Pro Glu Lys Val Asp Leu 130 135 140 Arg Leu Val Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 145 150 155 160 Phe Leu Ile Glu Gly Lys Phe Asp Thr Arg Asn Asn Asp Val Gin Arg 165 170 175 Leu Phe Gin Glu Phe Leu Ala Val Tyr Asp Asn Thr Phe Glu Asn Ser 180 185 190 Ser Leu Gin Glu Gin Asn Val Gin Val Glu Glu Ile Leu Thr Asp Lys 195 200 205 Ile Ser Lys Ser Ala Lys Lys Asp Arg Val Leu Lys Leu Phe Pro Asn 210 215 220 Glu Lys Ser Asn Gly Arg Phe Ala Glu Phe Leu Lys Leu Ile Val Gly 225 230 235 240 Asn Gin Ala Asp Phe Lys Lys His Phe Glu Leu Glu Glu Lys Ala Pro 245 250 255 Page 3070 of 3790 Leu Gin Phe Ser Lys Asp Thr Tyr Glu Glu Glu Leu Glu Val Leu Leu 260 265 270 Ala Gin Ile Gly Asp Asn Tyr Ala Glu Leu Phe Leu Ser Ala Lys Lys 275 280 285 Leu Tyr Asp Ser Ile Leu Leu Ser Gly Ile Leu Thr Val Thr Asp Val 290 295 300 Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Gin Arg Tyr Asn Glu 305 310 315 320 His Gin Met Asp Leu Ala Gin Leu Lys Gin Phe Ile Arg Gin Lys Leu 325 330 335 Ser Asp Lys Tyr Asn Glu Val Phe Ser Asp Val Ser Lys Asp Gly Tyr 340 345 350 Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gin Glu Ala Phe Tyr Lys Tyr 355 360 365 Leu Lys Gly Leu Leu Asn Lys Ile Glu Gly Ser Gly Tyr Phe Leu Asp 370 375 380 Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn 385 390 395 400 Gly Ser Ile Pro His Gin Ile His Leu Gin Glu Met Arg Ala Ile Ile 405 410 415 Arg Arg Gin Ala Glu Phe Tyr Pro Phe Leu Ala Asp Asn Gin Asp Arg 420 425 430 Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 435 440 445 Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu Ser Arg Lys Ser Ala Asp 450 455 460 Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile Val Asp Lys Glu Ser Ser 465 470 475 480 Ala Glu Ala Phe Ile Asn Arg Met Thr Asn Tyr Asp Leu Tyr Leu Pro 485 490 495 Asn Gin Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Thr 500 505 510 Page 3071 of 3790 Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Lys Thr Glu Gin Gly Lys 515 520 525 Thr Ala Phe Phe Asp Ala Asn Met Lys Gin Glu Ile Phe Asp Gly Val 530 535 540 Phe Lys Val Tyr Arg Lys Val Thr Lys Asp Lys Leu Met Asp Phe Leu 545 550 555 560 Glu Lys Glu Phe Asp Glu Phe Arg Ile Val Asp Leu Thr Gly Leu Asp 565 570 575 Lys Glu Asn Lys Ala Phe Asn Ala Ser Tyr Gly Thr Tyr His Asp Leu 580 585 590 Arg Lys Ile Leu Asp Lys Asp Phe Leu Asp Asn Ser Lys Asn Glu Lys 595 600 605 Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 610 615 620 Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser Asp Leu Leu Thr Lys Glu 625 630 635 640 Gin Val Lys Lys Leu Glu Arg Arg His Tyr Thr Gly Trp Gly Arg Leu 645 650 655 Ser Ala Glu Leu Ile His Gly Ile Arg Asn Lys Glu Ser Arg Lys Thr 660 665 670 Ile Leu Asp Tyr Leu Ile Asp Asp Gly Asn Ser Asn Arg Asn Phe Met 675 680 685 Gin Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala Lys 690 695 700 Ala Gin Val Ile Gly Glu Thr Asp Asn Leu Asn Gin Val Val Ser Asp 705 710 715 720 Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys 725 730 735 Ile Val Asp Glu Leu Val Lys Ile Met Gly His Gin Pro Glu Asn Ile 740 745 750 Val Val Glu Met Ala Arg Glu Asn Gin Phe Thr Asn Gin Gly Arg Arg Page 3072 of 3790 Page 3074 of 3790 1200 1338 PRT Streptococcus mutans Page 3075 of 3790 Tyr His Leu Arg Gin Tyr Leu Ala Asp Asn Pro Glu Lys Val Asp Leu 130 135 140 Arg Leu Val Tyr Leu Ala Leu Ala His Ile Ile Lys Phe Arg Gly His 145 150 155 160 Phe Leu Ile Glu Gly Lys Phe Asp Thr Arg Asn Asn Asp Val Gin Arg 165 170 175 Leu Phe Gin Glu Phe Leu Ala Val Tyr Asp Asn Thr Phe Glu Asn Ser 180 185 190 Ser Leu Gin Glu Gin Asn Val Gin Val Glu Glu Ile Leu Thr Asp Lys 195 200 205 Ile Ser Lys Ser Ala Lys Lys Asp Arg Val Leu Lys Leu Phe Pro Asn 210 215 220 Glu Lys Ser Asn Gly Arg Phe Ala Glu Phe Leu Lys Leu Ile Val Gly 225 230 235 240 Asn Gin Ala Asp Phe Lys Lys His Phe Glu Leu Glu Glu Lys Ala Pro 245 250 255 Leu Gin Phe Ser Lys Asp Thr Tyr Glu Glu Glu Leu Glu Val Leu Leu 260 265 270 Ala Gin Ile Gly Asp Asn Tyr Ala Glu Leu Phe Leu Ser Ala Lys Lys 275 280 285 Leu Tyr Asp Ser Ile Leu Leu Ser Gly Ile Leu Thr Val Thr Asp Val 290 295 300 Ser Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Gin Arg Tyr Asn Glu 305 310 315 320 His Gin Met Asp Leu Ala Gin Leu Lys Gin Phe Ile Arg Gin Lys Leu 325 330 335 Ser Asp Lys Tyr Asn Glu Val Phe Ser Asp Val Ser Lys Asp Gly Tyr 340 345 350 Ala Gly Tyr Ile Asp Gly Lys Thr Asn Gin Glu Ala Phe Tyr Lys Tyr 355 360 365 Leu Lys Gly Leu Leu Asn Lys Ile Glu Gly Ser Gly Tyr Phe Leu Asp 370 375 380 Page 3076 of 3790 Lys Ile Glu Arg Glu Asp Phe Leu Arg Lys Gin Arg Thr Phe Asp Asn 385 390 395 400 Gly Ser Ile Pro His Gin Ile His Leu Gin Glu Met Arg Ala Ile Ile 405 410 415 Arg Arg Gin Ala Glu Phe Tyr Pro Phe Leu Ala Asp Asn Gin Asp Arg 420 425 430 Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 435 440 445 Ala Arg Gly Lys Ser Asp Phe Ala Trp Leu Ser Arg Lys Ser Ala Asp 450 455 460 Lys Ile Thr Pro Trp Asn Phe Asp Glu Ile Val Asp Lys Glu Ser Ser 465 470 475 480 Ala Glu Ala Phe Ile Asn Arg Met Thr Asn Tyr Asp Leu Tyr Leu Pro 485 490 495 Asn Gin Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Lys Phe Thr 500 505 510 Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Lys Thr Glu Gin Gly Lys 515 520 525 Thr Ala Phe Phe Asp Ala Asn Met Lys Gin Glu Ile Phe Asp Gly Val 530 535 540 Phe Lys Val Tyr Arg Lys Val Thr Lys Asp Lys Leu Met Asp Phe Leu 545 550 555 560 Glu Lys Glu Phe Asp Glu Phe Arg Ile Val Asp Leu Thr Gly Leu Asp 565 570 575 Lys Glu Asn Lys Ala Phe Asn Ala Ser Tyr Gly Thr Tyr His Asp Leu 580 585 590 Arg Lys Ile Leu Asp Lys Asp Phe Leu Asp Asn Ser Lys Asn Glu Lys 595 600 605 Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 610 615 620 Met Ile Arg Lys Arg Leu Glu Asn Tyr Ser Asp Leu Leu Thr Lys Glu Page 3078 of 3790 Val Ala Tyr Ser Ile Leu Val Ile Ala Asp Ile Glu Lys Gly Lys 1115 1120 1125 Page 3079 of 3790 1201 1345 PRT Streptococcus mutans 1201 Page 3080 of 3790 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Phe Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Page 3081 of 3790 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ser Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser Page 3083 of 3790 Page 3084 of 3790 Page 3085 of 3790 1340 1345 1202 1345 PRT Streptococcus mutans Page 3086 of 3790 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn Page 3087 of 3790 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ser Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Glu Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Page 3088 of 3790 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Page 3089 of 3790 Ile Pro Arg Lys Thr Lys Lys Phe Tyr Trp Asp Thr Lys Lys Tyr 1100 1105 1110 Page 3090 of 3790 Leu Ser Lys Leu Gly Gly Asp Page 3091 of 3790 1340 1345 1203 1229 PRT Streptococcus mutans Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg Page 3093 of 3790 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Page 3094 of 3790 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 930 935 940 Glu Asn Asn Lys Lys Ile Arg Gin Val Lys Ile Val Thr Leu Lys Ser 945 950 955 960 Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 965 970 975 Page 3095 of 3790 Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Ile Gly Lys Ala Leu Leu Gly Val Tyr Pro Gin Leu Glu Pro Glu Phe 995 1000 1005 Lys Lys Ser Gin Asp Leu Leu Tyr His Ala His His Leu Asp Asn Page 3096 of 3790 1215 1205 1210 Asp Tyr Ser Asn Glu Tyr Val Lys Asn His Tyr 1220 1225 1204 1229 PRT Streptococcus mutans Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Ile Gin Val Page 3097 of 3790 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Thr Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Page 3098 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Page 3099 of 3790 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 930 935 940 Glu Asn Asn Lys Lys Ile Arg Gin Val Lys Ile Val Thr Leu Lys Ser 945 950 955 960 Page 3100 of 3790 Ala Ser Ser Lys Glu Val His Lys Gly Asn Gin Leu Val Val Ser Page 3101 of 3790 1190 1195 1200 Lys Lys Ser Gin Asp Leu Leu Tyr His Ala His His Leu Asp Asn 1205 1210 1215 Asp Tyr Ser Asn Glu Tyr Val Lys Asn His Tyr 1220 1225 1205 1345 PRT Streptococcus mutans Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr Page 3103 of 3790 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Ile Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Page 3104 of 3790 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 930 935 940 Page 3105 of 3790 Glu Glu Asn Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Lys Leu Page 3106 of 3790 1175 1180 1185 1340 1345 Ser Val 15 Gly Trp Ala Val Val 20 Thr Asp Asp Tyr Lys Val 25 Pro Ala Lys 30 Lys Met Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu Page 3107 of 3790 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Page 3108 of 3790 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Thr Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Ser Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Page 3109 of 3790 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Page 3110 of 3790 Lys Val Lys Leu Ala Asp Asp Gin Ile Val Glu Arg Pro Met Ile Page 3112 of 3790 1207 1350 PRT Streptococcus mutans Page 3113 of 3790 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Thr Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Page 3114 of 3790 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Page 3115 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Gin Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 865 870 875 880 Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gin Arg Lys 885 890 895 Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 900 910 Page 3116 of 3790 905 1208 1345 PRT Streptococcus mutans 1208 Page 3118 of 3790 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Page 3119 of 3790 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Page 3120 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Ile Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Page 3121 of 3790 Page 3123 of 3790 1340 1345 1209 1350 PRT Streptococcus mutans Page 3124 of 3790 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Thr Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3125 of 3790 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Ser Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu Page 3127 of 3790 Page 3128 of 3790 Page 3129 of 3790 1210 1350 PRT Streptococcus mutans Page 3130 of 3790 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Thr Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu Page 3132 of 3790 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Gin Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 865 870 875 880 Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gin Arg Lys 885 890 895 Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Leu Asp Asp Lys Ala Gly 900 905 910 Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys His Val 915 920 925 Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 930 935 940 Lys Arg Ile Cys Lys Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 945 950 955 960 Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 965 970 975 Page 3133 of 3790 Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 980 985 990 Ala Leu Leu Val Lys Tyr Ser Lys Leu Glu Pro Glu Phe Val Tyr Gly 995 1000 1005 Page 3134 of 3790 1211 1345 PRT Streptococcus mutans 1211 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Page 3135 of 3790 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Thr Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys Page 3137 of 3790 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Page 3138 of 3790 Pro Gin Val Asn Ile Val Lys Lys Val Glu Glu Gin Thr Gly Gly 1070 1075 1080 Page 3139 of 3790 Asp Arg Lys Arg Tyr Thr Ser Thr Thr Glu Ile Leu Asn Ala Thr Page 3140 of 3790 1310 1315 1320 Leu Ile His Gin Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 1325 1330 1335 Leu Ser Lys Leu Gly Gly Asp 1340 1345 1212 1345 PRT Streptococcus mutans 1212 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr Page 3142 of 3790 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Page 3143 of 3790 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu His Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 930 935 940 Page 3144 of 3790 Glu Glu Asn Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Lys Leu Page 3145 of 3790 1175 1180 1185 1340 1345 Ser Val 15 Gly Trp Ala Val Val 20 Thr Asp Asp Tyr Lys Val 25 Pro Ala Lys 30 Lys Met Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu Page 3146 of 3790 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Page 3147 of 3790 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Page 3148 of 3790 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Page 3149 of 3790 Lys Lys Asp Asp Val Arg Thr Asp Lys Asn Gly Glu Ile Ile Trp Page 3151 of 3790 1340 1345 1214 1345 PRT Streptococcus mutans 1214 Page 3152 of 3790 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Page 3153 of 3790 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Page 3154 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 910 Page 3155 of 3790 905 Page 3156 of 3790 1340 1345 1215 1345 PRT Streptococcus mutans 1215 Page 3157 of 3790 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Page 3158 of 3790 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Thr Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Page 3159 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Page 3160 of 3790 Page 3162 of 3790 1340 1345 1216 1345 PRT Streptococcus mutans 1216 Page 3163 of 3790 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3164 of 3790 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu Page 3166 of 3790 Ile Pro Arg Lys Thr Lys Lys Phe Tyr Trp Asp Thr Lys Lys Tyr 1100 1105 1110 Page 3167 of 3790 Leu Ser Lys Leu Gly Gly Asp 1340 1345 Page 3168 of 3790 5 Gly Trp Ala Val Val 20 Lys Val Leu Gly Asn 35 Gly Ala Leu Leu Phe 50 Lys Arg Thr Ala Arg 65 Tyr Leu Gin Glu Ile 85 Phe Phe His Arg Leu 100 Gly Glu Arg His Pro 115 His Glu Asn Phe Pro 130 Asn Pro Glu Lys Val 145 Ile Ile Lys Phe Arg 165 Arg Asn Asn Asp Val 180 Asp Asn Thr Phe Glu 195 Glu Glu Ile Leu Thr 210 Gly Thr Asn Ser Val 15 Pro Ala Lys Lys Met 30 Lys Lys Asn Leu Leu 45 Ala Asp Arg Arg Leu 60 Arg Asn Arg Ile Leu 80 Lys Val Asp Asp Ser 95 Thr Glu Asp Lys Arg 110 Glu Glu Val Lys Tyr 125 Gin Tyr Leu Ala Asp 140 Leu Ala Leu Ala His 160 Gly Lys Phe Asp Thr 175 Phe Leu Ala Val Tyr 190 Gin Asn Val Gin Val 205 Ala Lys Lys Asp Arg 220 Page 3169 of 3790 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn 435 Gin Asp Arg Ile 440 Glu Lys Ile Leu Thr Phe Arg 445 Ile Pro Tyr Tyr Val 450 Gly Pro Leu Ala Arg Gly Lys 455 Ser Asp Phe Ala Trp 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu Page 3171 of 3790 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 930 935 940 Glu Asn Asn Lys Lys Ile Arg Gin Val Lys Ile Val Thr Leu Lys Ser 945 950 955 960 Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 965 970 975 Page 3172 of 3790 Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 985 990 Ile Gly Lys Ala Leu Leu Gly Val Tyr Pro Gin Leu Glu Pro Glu Phe 995 1000 1005 Page 3173 of 3790 1340 1345 1218 1345 PRT Streptococcus mutans 1218 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Page 3174 of 3790 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys Page 3176 of 3790 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Page 3177 of 3790 Pro Gin Val Asn Ile Val Lys Lys Val Glu Glu Gin Thr Gly Gly 1070 1075 1080 Page 3178 of 3790 Asp Arg Lys Arg Tyr Thr Ser Thr Thr Glu Ile Leu Asn Ala Thr Page 3179 of 3790 1310 1315 1320 Leu Ile His Gin Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 1325 1330 1335 Leu Ser Lys Leu Gly Gly Asp 1340 1345 1219 1345 PRT Streptococcus mutans 1219 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr Page 3181 of 3790 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Page 3182 of 3790 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu His Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 930 935 940 Page 3183 of 3790 Glu Glu Asn Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Lys Leu Page 3184 of 3790 1175 1180 1185 1340 1345 Ser Val 15 Gly Trp Ala Val Val 20 Thr Asp Asp Tyr Lys Val 25 Pro Ala Lys 30 Lys Met Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu Page 3185 of 3790 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Page 3186 of 3790 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Page 3187 of 3790 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Page 3188 of 3790 Lys Lys Asp Asp Val Arg Thr Asp Lys Asn Gly Glu Ile Ile Trp Page 3190 of 3790 1340 1345 1221 1345 PRT Streptococcus mutans 1221 Page 3191 of 3790 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Page 3192 of 3790 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Page 3193 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu His Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 910 Page 3194 of 3790 905 Page 3195 of 3790 1340 1345 1222 1345 PRT Streptococcus mutans 1222 Page 3196 of 3790 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Page 3197 of 3790 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Page 3198 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin Page 3199 of 3790 Page 3201 of 3790 1340 1345 1223 1359 PRT Streptococcus mutans 1223 Page 3202 of 3790 Gly Ser Arg Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Lys Tyr 115 120 125 His Lys Glu Phe Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Ala Asn 130 135 140 Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ser Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gin Leu Lys Ala 165 170 175 Glu Asn Thr Asn Val Gin Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 180 185 190 Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 195 200 205 Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Gin Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 275 280 285 Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 325 330 335 Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 340 345 350 Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 355 360 365 Page 3203 of 3790 Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 370 375 380 Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Val Trp Leu 385 390 395 400 Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gin Arg Thr Phe Asp 405 410 415 Asn Gly Ser Ile Pro His Gin Ile His Leu Gin Glu Met His Ala Ile 420 425 430 Leu Arg Arg Gin Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gin Asp 435 440 445 Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 450 455 460 Leu Val Arg Lys Gly Ser Arg Phe Ala Trp Ala Glu Tyr Lys Ala Asp 465 470 475 480 Glu Lys Ile Thr Pro Trp Asn Phe Asp Asp Ile Leu Asp Lys Glu Lys 485 490 495 Ser Ala Glu Lys Phe Ile Thr Arg Met Thr Leu Asn Asp Leu Tyr Leu 500 505 510 Pro Glu Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Thr Phe 515 520 525 Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Asn Glu Gin Gly 530 535 540 Glu Ala Lys Phe Phe Asp Ala Asn Met Lys Gin Glu Ile Phe Asp His 545 550 555 560 Val Phe Lys Glu Asn Arg Lys Val Thr Lys Asp Lys Leu Leu Asn Tyr 565 570 575 Leu Asn Lys Glu Phe Glu Glu Phe Arg Ile Val Asn Leu Thr Gly Leu 580 585 590 Asp Lys Glu Asn Lys Val Phe Asn Ser Ser Leu Gly Thr Tyr His Asp 595 600 605 Leu Arg Lys Ile Leu Asn Lys Ser Phe Leu Asp Asn Lys Glu Asn Glu Page 3205 of 3790 Ser Lys Glu Ser Ile Leu Pro Lys Gly Asn Ser Asp Lys Leu Ile 1100 1105 1110 Page 3206 of 3790 Page 3207 of 3790 Asn Lys Leu Gly Gly Asp 1355 1224 1359 PRT Streptococcus mutans 1224 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Met Gin Val Asp Glu Ser 85 90 95 Phe Phe Gin Arg Leu Asp Asp Ser Phe Leu Val Glu Glu Asp Lys Arg 100 105 110 Gly Ser Arg Tyr Pro Ile Phe Gly Thr Leu Lys Glu Glu Lys Lys Tyr 115 120 125 His Lys Glu Phe Lys Thr Ile Tyr His Leu Arg Glu Lys Leu Ala Asn 130 135 140 Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ser Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Gin Leu Lys Ala 165 170 175 Glu Asn Thr Asn Val Gin Ala Leu Phe Lys Asp Phe Val Glu Val Tyr 180 185 190 Asp Lys Thr Val Glu Glu Ser His Leu Ser Glu Met Thr Val Asp Ala 195 200 205 Page 3208 of 3790 Leu Ser Ile Leu Thr Glu Lys Val Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Val Glu Cys Tyr Pro Thr Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Gin Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Gly Leu Leu Gly Glu Ile Gly Asp Glu Tyr Ala Asp 275 280 285 Leu Phe Ala Ser Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Ala Val Asp Asp Asn Thr Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Val Lys Arg Tyr Lys Glu His Lys Glu Glu Leu Ala Ala Phe Lys 325 330 335 Arg Phe Ile Lys Glu Lys Leu Pro Lys Lys Tyr Glu Glu Ile Phe Lys 340 345 350 Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Val Gly Ala Asp Lys Lys 355 360 365 Leu Arg Lys Arg Ser Gly Lys Leu Ala Thr Glu Glu Glu Phe Tyr Lys 370 375 380 Tyr Val Lys Gly Ile Leu Asn Lys Val Glu Gly Ala Asp Val Trp Leu 385 390 395 400 Asp Lys Ile Asp Arg Glu Asp Phe Leu Arg Lys Gin Arg Thr Phe Asp 405 410 415 Asn Gly Ser Ile Pro His Gin Ile His Leu Gin Glu Met His Ala Ile 420 425 430 Leu Arg Arg Gin Gly Glu His Tyr Pro Phe Leu Lys Glu Asn Gin Asp 435 440 445 Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Page 3210 of 3790 Met Gin Leu Ile Asn Asp Asp Ala Leu Ser Phe Lys Glu Glu Ile Ala 705 710 715 720 Lys Ala Gin Val Ile Gly Glu Met Asp Gly Leu Asn Gin Val Val Ser 725 730 735 Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gin Ser Leu 740 745 750 Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His Asn Pro Ala Asn 755 760 765 Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr Thr Ala Lys Gly Arg 770 775 780 Arg Ser Ser Gin Lys Arg Tyr Lys Arg Leu Glu Glu Ala Ile Lys Asn 785 790 795 800 Leu Asp His Asp Leu Asn His Lys Ile Leu Lys Glu His Pro Thr Asp 805 810 815 Asn Gin Ala Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu Gin Asn 820 825 830 Gly Arg Asp Met Tyr Thr Glu Asp Pro Leu Asp Ile Asn Arg Leu Ser 835 840 845 Asp Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys Asp Asn 850 855 860 Ser Ile Asp Asn Arg Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys 865 870 875 880 Ser Asp Asp Val Pro Ser Glu Glu Val Val His Lys Met Lys Pro Phe 885 890 895 Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys Phe Asp 900 905 910 Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp Lys Ala 915 920 925 Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys His 930 935 940 Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp Glu Asn 945 950 955 960 Page 3211 of 3790 Page 3212 of 3790 1355 Ser Val 15 Gly Trp Ala Val Val 20 Thr Asp Asp Tyr Lys Val 25 Pro Ala Lys 30 Lys Met Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Page 3213 of 3790 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 100 105 110 Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 115 120 125 His Gin Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 130 135 140 Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 165 170 175 Glu Asn Thr Asp Val Gin Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 180 185 190 Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 195 200 205 Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 210 215 220 Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly Page 3215 of 3790 Gin Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 545 550 555 560 Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Ile Gin Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 580 585 590 Tyr Ala Thr Tyr Gin Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 595 600 605 Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Lys 625 630 635 640 Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gin Leu Ala Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 660 665 670 Arg Asp Lys Gin Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 675 680 685 Ala Gin Ser Asn Arg Asn Leu Met Gin Leu Ile Thr Asp Asp Asn Leu 690 695 700 Thr Phe Lys Asp Asp Ile Val Lys Ala Gin Tyr Val Asp Asn Ser Asp 705 710 715 720 Asp Leu His Gin Val Val Gin Ser Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Lys Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Ala Lys Gly Arg Arg Asn Ser Gin Gin Arg Tyr Lys Arg 770 775 780 Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 785 790 795 800 Page 3216 of 3790 Page 3217 of 3790 Glu Arg Asp Phe Ala Ser Ile Glu Glu Leu Ala Asp Gly Phe Ile Page 3218 of 3790 1280 1285 1290 1340 1345 1350 Gly Asp 1355 1226 1355 PRT Streptococcus mutans 1226 His Gin Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp Page 3220 of 3790 Gly Ser Asp Tyr Phe Leu Asp Gin Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met His Ala Ile Leu Arg Arg Gin Gly Asp Tyr Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 450 455 460 Ala Glu Tyr His Ser Asp Glu Ala Val Thr Pro Trp Asn Phe Asp Gin 465 470 475 480 Val Ile Asp Lys Glu Ser Ser Ala Gin Ala Phe Ile Glu His Met Thr 485 490 495 Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 515 520 525 Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 530 535 540 Gin Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 545 550 555 560 Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Ile Gin Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 580 585 590 Tyr Ala Thr Tyr Gin Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 595 600 605 Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Lys 625 630 635 640 Page 3221 of 3790 Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gin Leu Ala Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 660 665 670 Arg Asp Lys Gin Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 675 680 685 Ala Gin Ser Asn Arg Asn Leu Met Gin Leu Ile Thr Asp Asp Asn Leu 690 695 700 Thr Phe Lys Asp Asp Ile Val Lys Ala Gin Tyr Val Asp Asn Ser Asp 705 710 715 720 Asp Leu His Gin Val Val Gin Ser Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Lys Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Ala Lys Gly Arg Arg Asn Ser Gin Gin Arg Tyr Lys Arg 770 775 780 Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 785 790 795 800 Leu Lys Glu His Pro Thr Asp Asn Gin Ala Leu Gin Asn Asn Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 820 825 830 Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 835 840 845 Gin Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 850 855 860 Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 865 870 875 880 Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 885 890 895 Page 3222 of 3790 Pro Glu Lys Tyr Gly Gly Tyr Gin Lys Pro Thr Thr Ala Tyr Pro Gly Asp 1355 Page 3224 of 3790 5 Gly Trp Ala Val Val 20 Lys Val Leu Gly Asn 35 Gly Ala Leu Leu Phe 50 Lys Arg Thr Ala Arg 65 Tyr Leu Gin Glu Ile 85 Phe Phe His Arg Leu 100 Gly Glu Arg His Pro 115 His Glu Asn Phe Pro 130 Asn Pro Glu Lys Val 145 Ile Ile Lys Phe Arg 165 Arg Asn Asn Asp Val 180 Asp Asn Thr Phe Glu 195 Glu Glu Ile Leu Thr 210 Gly Thr Asn Ser Val 15 Pro Ala Lys Lys Met 30 Lys Lys Asn Leu Leu 45 Glu Asp Arg Arg Leu 60 Arg Asn Arg Ile Leu 80 Lys Val Asp Asp Ser 95 Thr Glu Asp Lys Arg 110 Glu Glu Val Lys Tyr 125 Gin Tyr Leu Ala Asp 140 Leu Ala Leu Ala His 160 Gly Lys Phe Asp Thr 175 Phe Leu Ala Val Tyr 190 Gin Asn Val Gin Val 205 Ala Lys Lys Asp Arg 220 Page 3225 of 3790 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Page 3226 of 3790 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Page 3227 of 3790 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 930 935 940 Glu Asn Asn Lys Lys Ile Arg Gin Val Lys Ile Val Thr Leu Lys Ser 945 950 955 960 Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 990 Page 3228 of 3790 985 Ile Gly Lys Ala Leu Leu Gly Val Tyr Pro Gin Leu Glu Pro Glu Phe 995 1000 1005 1228 1345 PRT Streptococcus mutans 1228 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Page 3230 of 3790 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Asp Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Page 3231 of 3790 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Page 3232 of 3790 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys Page 3233 of 3790 Pro Gin Val Asn Ile Val Lys Lys Val Glu Glu Gin Thr Gly Gly 1070 1075 1080 Page 3234 of 3790 Page 3235 of 3790 Leu Ile His Gin Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 1325 1330 1335 Leu Ser Lys Leu Gly Gly Asp 1340 1345 1229 1345 PRT Streptococcus mutans 1229 Page 3236 of 3790 Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 195 200 205 Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 210 215 220 Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Page 3237 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser Page 3239 of 3790 Page 3240 of 3790 1230 1345 PRT Streptococcus mutans Page 3241 of 3790 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 100 105 110 Phe Asp Ser Tyr Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 115 120 125 His Gin Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 130 135 140 Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 165 170 175 Glu Asn Thr Asp Val Gin Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 180 185 190 Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 195 200 205 Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 210 215 220 Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Arg Asn 225 230 235 240 Leu Val Ala Leu Ser Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Page 3242 of 3790 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 325 330 335 Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 340 345 350 Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 355 360 365 Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 370 375 380 Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met His Ala Ile Leu Arg Arg Gin Gly Asp Tyr Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys Page 3244 of 3790 Lys Lys Asp Asp Val Arg Thr Asp Lys Asn Gly Glu Ile Ile Trp 1040 1045 1050 Page 3245 of 3790 Page 3246 of 3790 1340 1345 1231 1345 PRT Streptococcus mutans 1231 Page 3247 of 3790 Met Ile Lys Phe Arg Gly His Phe 165 Leu Ile Glu Gly Glu Leu Asn Ala 170 175 Glu Asn Thr Asp Val Gin Lys Leu 180 Phe Ala Asp Phe Val Gly Val Tyr 185 190 Asp Arg Thr Phe Asp Asp Ser His 195 200 Leu Ser Glu Ile Thr Val Asp Ala 205 Ser Ser Ile Leu Thr Glu Lys Ile 210 215 Ser Lys Ser Arg Arg Leu Glu Lys 220 Leu Ile Asn Asn Tyr Pro Lys Glu 225 230 Lys Lys Asn Thr Leu Phe Arg Asn 235 240 Leu Val Ala Leu Ser Leu Gly Leu 245 Gin Pro Asn Phe Lys Thr Asn Phe 250 255 Lys Leu Ser Glu Asp Ala Lys Leu 260 Gin Phe Ser Lys Asp Thr Tyr Glu 265 270 Glu Asp Leu Glu Glu Leu Leu Gly 275 280 Lys Ile Gly Asp Asp Tyr Ala Asp 285 Leu Phe Thr Leu Ala Lys Asn Leu 290 295 Tyr Asp Ala Ile Leu Leu Ser Gly 300 Ile Leu Thr Ala Asp Asp Ser Ser 305 310 Thr Lys Ala Pro Leu Ser Ala Ser 315 320 Met Ile Lys Arg Tyr Ala Glu His 325 His Glu Asp Leu Glu Lys Leu Lys 330 335 Glu Phe Ile Lys Ala Asn Lys Pro 340 Glu Leu Tyr His Asp Ile Phe Lys 345 350 Asp Glu Thr Lys Asn Gly Tyr Ala 355 360 Gly Tyr Ile Glu Asn Gly Val Lys 365 Gin Asp Glu Phe Tyr Lys Tyr Leu 370 375 Lys Asn Thr Leu Ser Lys Ile Ala 380 Gly Ser Asp Tyr Phe Leu Asp Lys 385 390 Ile Glu Arg Glu Asp Phe Leu Arg 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu Page 3249 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Page 3250 of 3790 Page 3251 of 3790 1340 1345 1232 1345 PRT Streptococcus mutans 1232 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 3252 of 3790 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Gly Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu Page 3254 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 3255 of 3790 Val Tyr Gly Asp Tyr Pro His Phe His Gly His Lys Glu Asn Lys 1010 1015 1020 Page 3256 of 3790 Val Val Ser Asn Phe Ser Lys Lys Tyr Thr Leu Ala Glu Gly Asn Page 3257 of 3790 1250 1255 1260 1340 1345 1233 1345 PRT Streptococcus mutans 1233 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr Page 3258 of 3790 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Gly Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3259 of 3790 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Page 3260 of 3790 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 865 870 875 880 Page 3261 of 3790 Gly Gly Phe Asp Ser Pro Ile Val Ala Tyr Ser Ile Leu Val Ile Leu Ser Lys Leu Gly Gly Asp 1340 1345 Page 3263 of 3790 5 Gly Trp Ala Val Val 20 Lys Val Leu Gly Asn 35 Gly Ala Leu Leu Phe 50 Lys Arg Thr Ala Arg 65 Tyr Leu Gin Glu Ile 85 Phe Phe His Arg Leu 100 Gly Glu Arg His Pro 115 His Glu Asn Phe Pro 130 Asn Pro Glu Lys Thr 145 Ile Ile Lys Phe Arg 165 Arg Asn Asn Asp Val 180 Asp Asn Thr Phe Glu 195 Glu Glu Ile Leu Thr 210 Gly Thr Asn Ser Val 15 Pro Ala Lys Lys Met 30 Lys Lys Asn Leu Leu 45 Glu Asp Arg Arg Leu 60 Arg Asn Arg Ile Leu 80 Lys Val Asp Asp Ser 95 Thr Glu Asp Lys Arg 110 Glu Glu Val Lys Tyr 125 Gin Tyr Leu Ala Asp 140 Leu Ala Leu Ala His 160 Gly Lys Phe Asp Thr 175 Phe Leu Ala Val Tyr 190 Gin Asn Val Gin Val 205 Ala Lys Lys Asp Arg 220 Page 3264 of 3790 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Page 3265 of 3790 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Page 3266 of 3790 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe His Thr Glu Thr Asp 930 935 940 Glu Asn Asn Lys Lys Ile Arg Gin Val Lys Ile Val Thr Leu Lys Ser 945 950 955 960 Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 990 Page 3267 of 3790 985 Ile Gly Lys Ala Leu Leu Gly Val Tyr Pro Gin Leu Glu Pro Glu Phe 995 1000 1005 1235 1345 PRT Streptococcus mutans 1235 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Page 3269 of 3790 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Page 3270 of 3790 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Page 3271 of 3790 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys Page 3272 of 3790 Page 3273 of 3790 Page 3274 of 3790 Leu Ile His Gin Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 1325 1330 1335 Leu Ser Lys Leu Gly Gly Asp 1340 1345 1236 1345 PRT Streptococcus mutans 1236 Page 3275 of 3790 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Page 3276 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser Page 3278 of 3790 Page 3279 of 3790 1237 1345 PRT Streptococcus mutans 1237 Page 3280 of 3790 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Page 3281 of 3790 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys Page 3283 of 3790 Page 3284 of 3790 Page 3285 of 3790 1340 1345 1238 1345 PRT Streptococcus mutans 1238 Page 3286 of 3790 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu Page 3288 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Page 3289 of 3790 Page 3290 of 3790 1340 1345 1239 1345 PRT Streptococcus mutans 1239 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 3291 of 3790 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu Page 3293 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 3294 of 3790 Val Tyr Gly Asp Tyr Pro His Phe His Gly His Lys Glu Asn Lys 1010 1015 1020 Page 3295 of 3790 Val Val Ser Asn Phe Ser Lys Lys Tyr Thr Leu Ala Glu Gly Asn Page 3296 of 3790 1250 1255 1260 1340 1345 1240 1345 PRT Streptococcus mutans Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr Page 3297 of 3790 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3298 of 3790 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Page 3299 of 3790 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Page 3300 of 3790 Gly Gly Phe Asp Ser Pro Ile Val Ala Tyr Ser Ile Leu Val Ile Leu Ser Lys Leu Gly Gly Asp 1340 1345 Page 3302 of 3790 5 Gly Trp Ala Val Val 20 Lys Val Leu Gly Asn 35 Gly Ala Leu Leu Phe 50 Lys Arg Thr Ala Arg 65 Tyr Leu Gin Glu Ile 85 Phe Phe His Arg Leu 100 Gly Glu Arg His Pro 115 His Glu Asn Phe Pro 130 Asn Pro Glu Lys Thr 145 Ile Ile Lys Phe Arg 165 Arg Asn Asn Asp Val 180 Asp Asn Thr Phe Glu 195 Glu Glu Ile Leu Thr 210 Gly Thr Asn Ser Val 15 Pro Ala Lys Lys Met 30 Lys Lys Asn Leu Leu 45 Glu Asp Arg Arg Leu 60 Arg Asn Arg Ile Leu 80 Lys Val Asp Asp Ser 95 Thr Glu Asp Lys Arg 110 Glu Glu Val Lys Tyr 125 Gin Tyr Leu Ala Asp 140 Leu Ala Leu Ala His 160 Gly Lys Phe Asp Thr 175 Phe Leu Ala Val Tyr 190 Gin Asn Val Gin Val 205 Ala Lys Lys Asp Arg 220 Page 3303 of 3790 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Page 3304 of 3790 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Leu Ala Ile Lys Lys 725 730 735 Page 3305 of 3790 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Gly Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Asn Thr Glu Thr Asp 930 935 940 Glu Asn Asn Lys Lys Ile Arg Gin Val Lys Ile Val Thr Leu Lys Ser 945 950 955 960 Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 990 Page 3306 of 3790 985 Ile Gly Lys Ala Leu Leu Gly Val 995 1000 Tyr Pro Gin Leu Glu Pro Glu Phe 1242 1345 PRT Streptococcus mutans 1242 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Page 3308 of 3790 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Lys Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Leu Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Page 3309 of 3790 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Page 3310 of 3790 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys Page 3311 of 3790 Page 3312 of 3790 Page 3313 of 3790 Leu Ile His Gin Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 1325 1330 1335 Leu Ser Lys Leu Gly Gly Asp 1340 1345 1243 1345 PRT Streptococcus mutans 1243 Page 3314 of 3790 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Leu Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Page 3315 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Leu Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser Page 3317 of 3790 Page 3318 of 3790 1244 1345 PRT Streptococcus mutans 1244 Page 3319 of 3790 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Page 3320 of 3790 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys Page 3322 of 3790 Page 3323 of 3790 Page 3324 of 3790 1340 1345 1245 1345 PRT Streptococcus mutans 1245 Page 3325 of 3790 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu Page 3327 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Pro Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Page 3328 of 3790 Page 3329 of 3790 1340 1345 1246 1345 PRT Streptococcus mutans 1246 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 3330 of 3790 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu Page 3332 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 3333 of 3790 Val Tyr Gly Asp Tyr Pro His Phe His Gly His Lys Glu Asn Lys 1010 1015 1020 Page 3334 of 3790 Val Val Ser Asn Phe Ser Lys Lys Tyr Thr Leu Ala Glu Gly Asn Page 3335 of 3790 1250 1255 1260 1340 1345 1247 1345 PRT Streptococcus mutans 1247 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr Page 3336 of 3790 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3337 of 3790 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Page 3338 of 3790 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Page 3339 of 3790 Gly Gly Phe Asp Ser Pro Ile Val Ala Tyr Ser Ile Leu Val Ile Leu Ser Lys Leu Gly Gly Asp 1340 1345 Page 3341 of 3790 5 Gly Trp Ala Val Val 20 Lys Val Leu Gly Asn 35 Gly Ala Leu Leu Phe 50 Lys Arg Thr Ala Arg 65 Tyr Leu Gin Glu Ile 85 Phe Phe His Arg Leu 100 Gly Glu Arg His Pro 115 His Glu Asn Phe Pro 130 Asn Pro Glu Lys Val 145 Ile Ile Lys Phe Arg 165 Arg Asn Asn Asp Val 180 Asp Asn Thr Phe Glu 195 Glu Glu Ile Leu Thr 210 Gly Thr Asn Ser Val 15 Pro Ala Lys Lys Met 30 Lys Lys Asn Leu Leu 45 Glu Asp Arg Arg Leu 60 Arg Asn Arg Ile Leu 80 Lys Val Asp Asp Ser 95 Thr Glu Asp Lys Arg 110 Glu Glu Val Lys Tyr 125 Gin Tyr Leu Ala Asp 140 Leu Ala Leu Ala His 160 Gly Lys Phe Asp Thr 175 Phe Leu Ala Val Tyr 190 Gin Asn Val Gin Val 205 Ala Lys Lys Asp Arg 220 Page 3342 of 3790 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Page 3343 of 3790 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Page 3344 of 3790 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Gin Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 930 935 940 Glu Asn Asn Lys Lys Ile Arg Gin Val Lys Ile Val Thr Leu Lys Ser 945 950 955 960 Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 990 Page 3345 of 3790 985 Ile Gly Lys Ala Leu Leu Gly Val Tyr Pro Gin Leu Glu Pro Glu Phe 995 1000 1005 1249 1345 PRT Streptococcus mutans 1249 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Page 3347 of 3790 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Page 3348 of 3790 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Page 3349 of 3790 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Gin Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys Page 3350 of 3790 Pro Gin Val Asn Ile Val Lys Lys Val Glu Glu Gin Thr Gly Gly 1070 1075 1080 Page 3351 of 3790 Page 3352 of 3790 Leu Ile His Gin Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 1325 1330 1335 Leu Ser Lys Leu Gly Gly Asp 1340 1345 1250 1345 PRT Streptococcus mutans Page 3353 of 3790 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Page 3354 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser Page 3356 of 3790 Page 3357 of 3790 1251 1345 PRT Streptococcus mutans 1251 Page 3358 of 3790 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Page 3359 of 3790 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys Page 3361 of 3790 Page 3362 of 3790 Page 3363 of 3790 1340 1345 1252 1345 PRT Streptococcus mutans 1252 Page 3364 of 3790 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu Page 3366 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Page 3367 of 3790 Page 3368 of 3790 1340 1345 1253 1345 PRT Streptococcus mutans 1253 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 3369 of 3790 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu Page 3371 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 3372 of 3790 Val Tyr Gly Asp Tyr Pro His Phe His Gly His Lys Glu Asn Lys 1010 1015 1020 Page 3373 of 3790 Val Val Ser Asn Phe Ser Lys Lys Tyr Thr Leu Ala Glu Gly Asn Page 3374 of 3790 1250 1255 1260 1340 1345 1254 1345 PRT Streptococcus mutans 1254 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr Page 3375 of 3790 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3376 of 3790 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Page 3377 of 3790 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Page 3378 of 3790 Gly Gly Phe Asp Ser Pro Ile Val Ala Tyr Ser Ile Leu Val Ile Leu Ser Lys Leu Gly Gly Asp 1340 1345 Page 3380 of 3790 5 Gly Trp Ala Val Val 20 Lys Val Leu Gly Asn 35 Gly Ala Leu Leu Phe 50 Lys Arg Thr Ala Arg 65 Tyr Leu Gin Glu Ile 85 Phe Phe His Arg Leu 100 Gly Glu Arg His Pro 115 His Glu Asn Phe Pro 130 Asn Pro Glu Lys Val 145 Ile Ile Lys Phe Arg 165 Arg Asn Asn Asp Val 180 Asp Asn Thr Phe Glu 195 Glu Glu Ile Leu Thr 210 Gly Thr Asn Ser Val 15 Pro Ala Lys Lys Met 30 Lys Lys Asn Leu Leu 45 Glu Asp Arg Arg Leu 60 Arg Asn Arg Ile Leu 80 Lys Val Asp Asp Ser 95 Thr Glu Asp Lys Arg 110 Glu Glu Val Lys Tyr 125 Gin Tyr Leu Ala Asp 140 Leu Ala Leu Ala His 160 Gly Lys Phe Asp Thr 175 Phe Leu Ala Val Tyr 190 Gin Asn Val Gin Val 205 Ala Lys Lys Asp Arg 220 Page 3381 of 3790 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Page 3382 of 3790 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Page 3383 of 3790 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Lys His Val Ala Arg Ile Leu Asp Glu Arg Phe Tyr Thr Glu Thr Asp 930 935 940 Glu Asn Asn Lys Lys Ile Arg Gin Val Lys Ile Val Thr Leu Lys Ser 945 950 955 960 Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg 965 970 975 Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 980 990 Page 3384 of 3790 985 Ile Gly Lys Ala Leu Leu Gly Val Tyr Pro Gin Leu Glu Pro Glu Phe 995 1000 1005 1256 1345 PRT Streptococcus mutans 1256 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Page 3386 of 3790 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Page 3387 of 3790 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Page 3388 of 3790 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys Page 3389 of 3790 Pro Gin Val Asn Ile Val Lys Lys Val Glu Glu Gin Thr Gly Gly 1070 1075 1080 Page 3390 of 3790 Page 3391 of 3790 Leu Ile His Gin Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp 1325 1330 1335 Leu Ser Lys Leu Gly Gly Asp 1340 1345 1257 1345 PRT Streptococcus mutans 1257 Page 3392 of 3790 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Page 3393 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser Page 3395 of 3790 Page 3396 of 3790 1258 1345 PRT Streptococcus mutans 1258 Page 3397 of 3790 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asn Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Page 3398 of 3790 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys Page 3400 of 3790 Page 3401 of 3790 Page 3402 of 3790 1340 1345 1259 1345 PRT Streptococcus mutans 1259 Page 3403 of 3790 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu Page 3405 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Lys Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Page 3406 of 3790 Page 3407 of 3790 1340 1345 1260 1345 PRT Streptococcus mutans 1260 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 3408 of 3790 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Thr Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Cys Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu Page 3410 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 3411 of 3790 Page 3412 of 3790 Val Val Ser Asn Phe Ser Lys Lys Tyr Thr Leu Ala Glu Gly Asn Page 3413 of 3790 1250 1255 1260 1340 1345 1261 1345 PRT Streptococcus mutans 1261 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr Page 3414 of 3790 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Thr Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Cys Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Thr Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3415 of 3790 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Ser Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Page 3416 of 3790 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Page 3417 of 3790 Gly Gly Phe Asp Ser Pro Ile Val Ala Tyr Ser Ile Leu Val Ile Leu Ser Lys Leu Gly Gly Asp 1340 1345 Page 3419 of 3790 1262 1350 PRT Streptococcus mutans 1262 Page 3420 of 3790 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Thr Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Page 3421 of 3790 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Page 3422 of 3790 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val Val Asn Arg Met Arg 865 870 875 880 Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu Ile Ser Gin Arg Lys 885 890 895 Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro Asp Asp Lys Ala Gly 900 905 910 Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr Lys His Val 915 920 925 Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu Phe Asp Asp Asn Asn 930 935 940 Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu Lys Ser Asn Leu Val 945 950 955 960 Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys Val Arg Glu Ile Asn 965 970 975 Asp Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Val Lys 980 990 Page 3423 of 3790 985 Ala Leu Leu Val Lys Tyr Pro Lys Leu Glu Pro Glu Phe Val Tyr Gly 995 1000 1005 Page 3424 of 3790 1263 1350 PRT Streptococcus mutans 1263 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Thr Val Leu Gly Asn Thr Asp Lys Ser His Ile Lys Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Ala Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Page 3425 of 3790 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Thr Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Page 3426 of 3790 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Page 3427 of 3790 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys Page 3428 of 3790 Page 3430 of 3790 Cys Met Glu Ala Thr Leu Ile His Gin Ser Ile Thr Gly Leu Tyr 1325 1330 1335 Glu Thr Arg Ile Asp Leu Ser Lys Leu Gly Gly Asp Page 3431 of 3790 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Ile Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Page 3432 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Val Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Ala Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Arg Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Lys Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Leu Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser Page 3434 of 3790 Page 3435 of 3790 1265 1345 PRT Streptococcus mutans 1265 Page 3436 of 3790 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ala Glu Glu Met Ser Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Page 3437 of 3790 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys Page 3439 of 3790 Page 3440 of 3790 Page 3441 of 3790 1340 1345 1266 1345 PRT Streptococcus mutans 1266 Page 3442 of 3790 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu Page 3444 of 3790 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu His Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asn Val Val Arg Lys Met Lys 865 870 875 880 Ser Tyr Trp Ser Lys Leu Leu Ser Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Thr Asp Asp Asp 900 905 910 Page 3445 of 3790 Page 3446 of 3790 1340 1345 1267 1345 PRT Streptococcus mutans 1267 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Page 3447 of 3790 Gly Trp Ser Val Val Thr Asp Asp Tyr Lys Val Pro Ala Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys Ser His Ile Glu Lys Asn Leu Leu 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Asn Thr Ala Glu Asp Arg Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Glu Asp Ser Phe Leu Val Thr Glu Asp Lys Arg 100 105 110 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu Page 3449 of 3790 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Page 3450 of 3790 Page 3451 of 3790 Val Val Ser Asn Phe Ser Lys Lys Tyr Thr Leu Ala Glu Gly Asn Page 3452 of 3790 1250 1255 1260 1340 1345 1268 1345 PRT Streptococcus mutans 1268 Gly Glu Arg His Pro Ile Phe Gly Asn Leu Glu Glu Glu Val Lys Tyr Page 3453 of 3790 115 120 125 His Glu Asn Phe Pro Thr Ile Tyr His Leu Arg Gin Tyr Leu Ala Asp 130 135 140 Asn Pro Glu Lys Val Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Phe Asp Thr 165 170 175 Arg Asn Asn Asp Val Gin Arg Leu Phe Gin Glu Phe Leu Ala Val Tyr 180 185 190 Asp Asn Thr Phe Glu Asn Ser Ser Leu Gin Glu Gin Asn Val Gin Val 195 200 205 Glu Glu Ile Leu Thr Asp Lys Ile Ser Lys Ser Ala Lys Lys Asp Arg 210 215 220 Val Leu Lys Leu Phe Pro Asn Glu Lys Ser Asn Gly Arg Phe Ala Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Glu Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Glu Leu Glu Val Leu Leu Ala Gin Ile Gly Asp Asn Tyr Ala Glu 275 280 285 Leu Phe Leu Ser Ala Lys Lys Leu Tyr Asp Ser Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Val Thr Asp Val Gly Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Gin Arg Tyr Asn Glu His Gin Met Asp Leu Ala Gin Leu Lys 325 330 335 Gin Phe Ile Arg Gin Lys Leu Ser Asp Lys Tyr Asn Glu Val Phe Ser 340 345 350 Asp Val Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3454 of 3790 Gin Glu Ala Phe Tyr Lys Tyr Leu Lys Gly Leu Leu Asn Lys Ile Glu 370 375 380 Gly Ser Gly Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Ile Arg Arg Gin Ala Glu Phe Tyr Pro Phe 420 425 430 Leu Ala Asp Asn Gin Asp Arg Ile Glu Lys Leu Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Lys Ser Asp Phe Ala Trp 450 455 460 Leu Ser Arg Lys Ser Ala Asp Lys Ile Thr Pro Trp Asn Phe Asp Glu 465 470 475 480 Ile Val Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Asn Gin Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Lys Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Lys Thr Glu Gin Gly Lys Thr Ala Phe Phe Asp Ala Asn Met Lys 530 535 540 Gin Glu Ile Phe Asp Gly Val Phe Lys Val Tyr Arg Lys Val Thr Lys 545 550 555 560 Asp Lys Leu Met Asp Phe Leu Glu Lys Glu Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Leu Thr Gly Leu Asp Lys Glu Asn Lys Val Phe Asn Ala Ser 580 585 590 Tyr Gly Thr Tyr His Asp Leu Cys Lys Ile Leu Asp Lys Asp Phe Leu 595 600 605 Asp Asn Ser Lys Asn Glu Lys Ile Leu Glu Asp Ile Val Leu Thr Leu 610 615 620 Page 3455 of 3790 Thr Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Asn Tyr 625 630 635 640 Ser Asp Leu Leu Thr Lys Glu Gin Val Lys Lys Leu Glu Arg Arg His 645 650 655 Tyr Thr Gly Trp Gly Arg Leu Ser Ala Glu Leu Ile His Gly Ile Arg 660 665 670 Asn Lys Glu Ser Arg Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly 675 680 685 Asn Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Ala Leu Ser 690 695 700 Phe Lys Glu Glu Ile Ala Lys Ala Gin Val Ile Gly Glu Thr Asp Asn 705 710 715 720 Leu Asn Gin Val Val Ser Asp Ile Ala Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Ile Met 740 745 750 Gly His Gin Pro Glu Asn Ile Val Val Glu Met Ala Arg Glu Asn Gin 755 760 765 Phe Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Leu Lys Gly Leu 770 775 780 Thr Asp Ser Ile Lys Glu Phe Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Ser Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Glu Leu Asp Ile Asp Tyr 820 825 830 Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe Ile Lys 835 840 845 Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Glu Asn Arg 850 855 860 Gly Lys Ser Asp Asp Val Pro Ser Lys Asp Val Val Arg Lys Met Lys 865 870 875 880 Page 3456 of 3790 Gly Gly Phe Asp Ser Pro Ile Val Ala Tyr Ser Ile Leu Val Ile Leu Ser Lys Leu Gly Gly Asp 1340 1345 Page 3458 of 3790 5 Gly Trp Ala Val Val 20 Lys Val Leu Gly Asn 35 Gly Ala Leu Leu Phe 50 Lys Arg Thr Ala Arg 65 Tyr Leu Gin Glu Ile 85 Phe Phe His Arg Leu 100 Phe Asp Ser His Pro 115 His Gin Lys Phe Pro 130 Ser Thr Glu Lys Ala 145 Met Ile Lys Phe Arg 165 Glu Asn Thr Asp Val 180 Asp Arg Thr Phe Asp 195 Ser Ser Ile Leu Thr 210 Gly Thr Asn Ser Val 15 Pro Ala Lys Lys Met 30 Lys Lys Asn Leu Leu 45 Glu Asp Arg Arg Leu 60 Arg Asn Arg Ile Leu 80 Lys Val Asp Asp Ser 95 Asp Asp Asp Lys Asn 110 Glu Glu Asp Ala Tyr 125 Lys His Leu Ala Asp 140 Leu Ala Leu Ala His 160 Gly Glu Leu Asn Ala 175 Phe Val Gly Val Tyr 190 Ile Thr Val Asp Ala 205 Arg Arg Leu Glu Lys 220 Page 3459 of 3790 Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 325 330 335 Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 340 345 350 Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 355 360 365 Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 370 375 380 Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met His Ala Ile Leu Arg Arg Gin Gly Asp Tyr Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 450 455 460 Ala Glu Tyr His Ser Asp Glu Ala Val Met Pro Trp Asn Phe Asp Gin 465 470 475 480 Page 3460 of 3790 Val Ile Asp Lys Glu Ser Ser Ala Gin Ala Phe Ile Glu His Met Thr 485 490 495 Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 515 520 525 Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 530 535 540 Gin Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 545 550 555 560 Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 565 570 575 Val Asp Ile Gin Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 580 585 590 Tyr Ala Thr Tyr Gin Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 595 600 605 Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Lys 625 630 635 640 Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gin Leu Ala Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 660 665 670 Arg Asp Lys Gin Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 675 680 685 Ala Gin Ser Asn Arg Asn Leu Met Gin Leu Ile Thr Asp Asp Asn Leu 690 695 700 Thr Phe Lys Asp Asp Ile Val Lys Ala Gin Tyr Val Asp Asn Ser Asp 705 710 715 720 Asp Leu His Gin Val Val Gin Ser Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Page 3461 of 3790 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Lys Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Ala Lys Gly Arg Arg Asn Ser Gin Gin Arg Tyr Lys Arg 770 775 780 Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 785 790 795 800 Leu Lys Glu His Pro Thr Asp Asn Gin Ala Leu Gin Asn Asn Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 820 825 830 Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Ile Asp His Val Ile Pro 835 840 845 Gin Ala Phe Ile Lys Asp Asn Ser Ile Asp Asn Arg Val Leu Thr Ser 850 855 860 Ser Lys Ala Asn Arg Gly Lys Ser Asp Asp Val Pro Ser Glu Asp Val 865 870 875 880 Val Asn Arg Met Arg Pro Phe Trp Asn Lys Leu Leu Ser Ser Gly Leu 885 890 895 Ile Ser Gin Arg Lys Tyr Asn Asn Leu Thr Lys Lys Glu Leu Thr Pro 900 905 910 Asp Asp Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin 915 920 925 Ile Thr Lys His Val Ala Arg Met Leu Asp Glu Arg Phe Asn Lys Glu 930 935 940 Phe Asp Asp Asn Asn Lys Arg Ile Arg Arg Val Lys Ile Val Thr Leu 945 950 955 960 Lys Ser Asn Leu Val Ser Ser Phe Arg Lys Glu Phe Glu Leu Tyr Lys 965 970 975 Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu Asn 980 990 Page 3462 of 3790 985 Ala Val Val Val Lys Ala Leu Leu Val Lys Tyr Pro Lys Leu Glu Pro 995 1000 1005 Page 3463 of 3790 Gly Asp 1355 1270 1355 PRT Streptococcus mutans Page 3464 of 3790 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Arg Asn Arg Ile Leu 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Met Gly Lys Val Asp Asp Ser 85 90 95 Phe Phe His Arg Leu Asp Glu Ser Phe Leu Thr Asp Asp Asp Lys Asn 100 105 110 Phe Asp Ser His Pro Ile Phe Gly Asn Lys Ala Glu Glu Asp Ala Tyr 115 120 125 His Gin Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 130 135 140 Ser Thr Glu Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Glu Leu Asn Ala 165 170 175 Glu Asn Thr Asp Val Gin Lys Leu Phe Ala Asp Phe Val Gly Val Tyr 180 185 190 Asp Arg Thr Phe Asp Asp Ser His Leu Ser Glu Ile Thr Val Asp Ala 195 200 205 Ser Ser Ile Leu Thr Glu Lys Ile Ser Lys Ser Arg Arg Leu Glu Lys 210 215 220 Leu Ile Asn Asn Tyr Pro Lys Glu Lys Lys Asn Thr Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn Phe 245 250 255 Lys Leu Ser Glu Asp Ala Lys Leu Gin Phe Ser Lys Asp Thr Tyr Glu 260 265 270 Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala Asp 275 280 285 Leu Phe Thr Leu Ala Lys Asn Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Ile Leu Thr Ala Asp Asp Ser Ser Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Page 3465 of 3790 Met Ile Lys Arg Tyr Ala Glu His His Glu Asp Leu Glu Lys Leu Lys 325 330 335 Glu Phe Ile Lys Ala Asn Lys Pro Glu Leu Tyr His Asp Ile Phe Lys 340 345 350 Asp Glu Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Asn Gly Val Lys 355 360 365 Gin Asp Glu Phe Tyr Lys Tyr Leu Lys Asn Thr Leu Ser Lys Ile Ala 370 375 380 Gly Ser Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met His Ala Ile Leu Arg Arg Gin Gly Asp Tyr Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Gin Asp Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Lys Asn Ser Arg Phe Ala Trp 450 455 460 Ala Glu Tyr His Ser Asp Glu Ala Val Met Pro Trp Asn Phe Asp Gin 465 470 475 480 Val Ile Asp Lys Glu Ser Ser Ala Gin Ala Phe Ile Glu His Met Thr 485 490 495 Asn Asn Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr Lys Ile Lys 515 520 525 Tyr Val Thr Glu Ile Gly Glu Ala Lys Phe Phe Asp Ala Asn Leu Lys 530 535 540 Gin Glu Ile Phe Asp Gly Leu Phe Lys His Glu Arg Lys Val Thr Lys 545 550 555 560 Lys Lys Leu Arg Thr Phe Leu Asp Lys Asn Phe Asp Glu Phe Arg Ile 565 570 575 Page 3466 of 3790 Val Asp Ile Gin Gly Leu Asp Lys Glu Thr Glu Thr Phe Asn Ala Ser 580 585 590 Tyr Ala Thr Tyr Gin Asp Leu Leu Lys Val Ile Lys Asp Lys Val Phe 595 600 605 Met Asp Asn Pro Glu Asn Ala Glu Ile Leu Glu Asn Ile Val Leu Thr 610 615 620 Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Lys 625 630 635 640 Tyr Ala Asp Val Phe Asp Lys Lys Val Ile Asp Gin Leu Ala Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu Asn Gly Ile 660 665 670 Arg Asp Lys Gin Ser Cys Lys Thr Ile Met Asp Tyr Leu Ile Asp Asp 675 680 685 Ala Gin Ser Asn Arg Asn Leu Met Gin Leu Ile Thr Asp Asp Asn Leu 690 695 700 Thr Phe Lys Asp Asp Ile Val Lys Ala Gin Tyr Val Asp Asn Ser Asp 705 710 715 720 Asp Leu His Gin Val Val Gin Ser Leu Ala Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly Lys Glu Pro Glu Gin Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Ala Lys Gly Arg Arg Asn Ser Gin Gin Arg Tyr Lys Arg 770 775 780 Leu Lys Glu Ala Ile Lys Ser Leu Asp Arg Asp Leu Asn His Lys Ile 785 790 795 800 Leu Lys Glu His Pro Thr Asp Asn Gin Ala Leu Gin Asn Asn Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Glu Ser 820 830 Page 3467 of 3790 825 Page 3468 of 3790 Page 3469 of 3790 Gly Asp 1355 1271 1125 PRT Streptococcus mutans 1271 Page 3470 of 3790 Gly Gin Leu Arg Gly Asn Phe Thr Ile Gin Asp Glu Asn Gly Glu Tyr 165 170 175 His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 180 185 190 Arg Arg Ile Leu Glu Thr Gin Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 195 200 205 Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gin Gly Lys Arg Lys Tyr 210 215 220 Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 225 230 235 240 Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 245 250 255 Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 260 265 270 Thr Ala Gin Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 275 280 285 Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gin Lys Tyr Gin Leu Val 290 295 300 Asp Phe Ala Lys Thr Ala Ser Thr Leu Glu Ala Ala Lys Leu Leu Lys 305 310 315 320 Glu Ile Ala Lys Leu Val Gly Cys Gin Val Glu Glu Ile Lys Gly Tyr 325 330 335 Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 340 345 350 Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 355 360 365 Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Glu Glu Ala Ile Gin Lys Glu Leu Pro Asn Ile Phe 385 390 395 400 Ser Asp Glu Gin Ile Thr Gly Ile Ile Ala Val Arg Lys Lys Asn Ser 405 410 415 Page 3471 of 3790 Gin Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr Ile 435 440 445 Leu Ile Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 450 455 460 Thr Lys Tyr Ile Asn Glu Gin Glu Val Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ser Lys Ser Ile Arg Gin Thr Val Lys Ile Ile Asn Ala Ala 485 490 495 Ile Lys Lys Tyr Gly Ala Phe Asp Gin Ile Val Ile Glu Met Pro Arg 500 505 510 Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gin Lys 515 520 525 Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gin Ala Ala Leu Leu 530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro His Gly Val Phe His Gly His Lys 545 550 555 560 Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gin 580 585 590 His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Phe Gin Ala Leu Pro Gin Met Ala Ser Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gin Lys Gly Ile 645 650 655 Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gin Asp Ile Asn Lys Page 3473 of 3790 1272 1125 PRT Streptococcus mutans 1272 Page 3474 of 3790 Met Thr Asn Gly Lys Ile Leu Gly Leu Asp Ile Gly Ile Ala Ser Val 15 10 15 Gly Val Gly Ile Ile Asn Ala Lys Thr Gly Asn Val Glu His Ala Ser 20 25 30 Ser Arg Ile Phe Pro Ala Ala Asn Ala Asp Asn Asn Val Glu Arg Arg 35 40 45 Ser Ala Arg Gly Gly Arg Arg Leu Ile Arg Arg Lys Lys His Arg Leu 50 55 60 Lys Arg Val Glu Asp Leu Phe Glu Lys Tyr Asn Ile Asp Thr Asp Phe 65 70 75 80 Ser Asn Leu Asn Leu Asn Pro Tyr Gin Leu Arg Val Lys Gly Leu Asn 85 90 95 Glu Gin Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 100 105 110 Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 115 120 125 Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 130 135 140 Lys Lys Gin Thr Pro Gly Glu Ile Gin Leu Lys Arg Leu Glu Lys Tyr 145 150 155 160 Gly Gin Leu Arg Gly Asn Phe Thr Ile Gin Asp Glu Asn Gly Glu Tyr 165 170 175 His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 180 185 190 Arg Arg Ile Leu Glu Thr Gin Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 195 200 205 Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gin Gly Lys Arg Lys Tyr 210 215 220 Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 225 230 235 240 Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 245 250 255 Page 3475 of 3790 Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 260 265 270 Thr Ala Gin Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 275 280 285 Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gin Lys Tyr Gin Leu Val 290 295 300 Asp Phe Ala Lys Thr Ala Ser Thr Leu Gly Ala Ala Lys Leu Leu Lys 305 310 315 320 Glu Ile Ala Lys Leu Val Gly Cys Gin Val Glu Glu Ile Lys Gly Tyr 325 330 335 Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 340 345 350 Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 355 360 365 Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Glu Glu Ala Ile Gin Lys Glu Leu Pro Asn Ile Phe 385 390 395 400 Ser Asp Glu Gin Ile Thr Glu Ile Ile Ala Val Arg Lys Lys Asn Ser 405 410 415 Gin Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr Ile 435 440 445 Leu Thr Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 450 455 460 Thr Lys Tyr Ile Asn Glu Glu Glu Ile Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ser Lys Ser Ile Arg Gin Thr Val Lys Ile Ile Asn Ala Thr 485 490 495 Ile Lys Lys Tyr Gly Ala Phe Asp Gin Ile Ile Ile Glu Met Pro Arg 500 505 510 Page 3476 of 3790 Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gin Lys 515 520 525 Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gin Ala Ala Leu Leu 530 535 540 Tyr Asn Gly Lys Asp Glu Leu Pro His Asp Val Phe His Gly His Lys 545 550 555 560 Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gin 580 585 590 His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Phe Gin Ala Leu Pro Gin Met Ala Ser Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gin Lys Gly Ile 645 650 655 Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gin Asp Ile Asn Lys 660 665 670 Val Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gin Asp Ala Leu Lys Val 690 695 700 Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg Gin Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg 740 745 750 Leu Trp Lys Lys Gin Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly Page 3477 of 3790 1273 1125 PRT Streptococcus mutans 1273 Page 3479 of 3790 Glu Gin Leu Ser Asn Glu Glu Leu Phe Ala Ile Leu Lys Asn Ile Ala 100 105 110 Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Glu Asp Asp Ser Val 115 120 125 Gly Ser Ser Asp Tyr Ala Lys Ala Ile Asp Glu Asn Arg Lys Leu Leu 130 135 140 Lys Lys Gin Thr Pro Gly Glu Ile Gin Leu Lys Arg Leu Glu Lys Tyr 145 150 155 160 Gly Gin Leu Arg Gly Asn Phe Thr Ile Gin Asp Glu Asn Gly Glu Tyr 165 170 175 His Arg Leu Ile Asn Val Phe Ser Thr Ser Asp Tyr Val Lys Glu Ala 180 185 190 Arg Arg Ile Leu Glu Thr Gin Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 195 200 205 Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gin Gly Lys Arg Lys Tyr 210 215 220 Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 225 230 235 240 Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 245 250 255 Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 260 265 270 Thr Ala Gin Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 275 280 285 Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gin Lys Tyr Gin Leu Val 290 295 300 Asp Phe Ala Lys Thr Ala Ser Thr Leu Gly Ala Ala Lys Leu Leu Lys 305 310 315 320 Glu Ile Ala Lys Leu Val Gly Cys Gin Val Glu Glu Ile Lys Gly Tyr 325 330 335 Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 340 345 350 Page 3480 of 3790 Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 355 360 365 Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Glu Glu Ala Ile Gin Lys Glu Leu Pro Asn Ile Phe 385 390 395 400 Ser Asp Glu Gin Ile Thr Glu Ile Ile Ala Val Arg Lys Lys Asn Ser 405 410 415 Gin Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr Ile 435 440 445 Leu Thr Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 450 455 460 Thr Lys Tyr Ile Asn Glu Glu Glu Ile Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ser Lys Ser Ile Arg Gin Thr Val Lys Ile Ile Asn Ala Thr 485 490 495 Ile Lys Lys Tyr Gly Ala Phe Asp Gin Ile Ile Ile Glu Met Pro Arg 500 505 510 Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gin Lys 515 520 525 Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gin Ala Ala Leu Leu 530 535 540 Tyr Asn Gly Lys Asp Glu Leu Pro His Asp Val Phe His Gly His Lys 545 550 555 560 Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gin 580 585 590 His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 595 600 605 Page 3481 of 3790 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Phe Gin Ala Leu Pro Gin Met Ala Ser Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gin Lys Gly Ile 645 650 655 Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gin Asp Ile Asn Lys 660 665 670 Val Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gin Asp Ala Leu Lys Val 690 695 700 Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg Gin Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg 740 745 750 Leu Trp Lys Lys Gin Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 755 760 765 Gin Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 770 775 780 Lys Glu Leu Val Tyr Gin Ala Pro Tyr Gin Gly Phe Val Asn Thr Ile 785 790 795 800 Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gin Val Asp 805 810 815 Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 820 825 830 Gin Ala Gin Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 835 840 845 Lys Ile Lys Asp Ile Tyr Ser Gin Ala Gly Tyr Asp Ala Phe Arg Lys 850 855 Page 3482 of 3790 860 Lys Gly Leu Asn Lys Pro Asp Leu Ser Ile Tyr Lys Val Lys Thr 1085 1090 1095 Page 3483 of 3790 Asp Ile Leu Gly His Lys Tyr Tyr Ile Lys Lys Glu Gly Asp Lys 1100 1105 1110 Pro Lys Leu Asn Phe Glu Asn Lys Ile Lys Asn Lys Page 3484 of 3790 Arg Arg Ile Leu Glu Thr Gin Ser Tyr Tyr Asn Lys Phe Ile Thr Glu 195 200 205 Ser Phe Val Glu Asp Tyr Ile Lys Ile Leu Gin Gly Lys Arg Lys Tyr 210 215 220 Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr 225 230 235 240 Arg Thr Asp Gly Glu Thr Leu Asp Asn Leu Phe Gly Ile Leu Ile Gly 245 250 255 Lys Cys Gly Phe Tyr Pro Glu Glu Tyr Arg Ala Ala Lys Ala Ser Tyr 260 265 270 Thr Ala Gin Glu Tyr Asn Phe Leu Asn Asp Leu Asn Asn Leu Thr Val 275 280 285 Pro Thr Glu Thr Lys Lys Leu Ser Thr Glu Gin Lys Tyr Gin Leu Val 290 295 300 Asp Phe Ala Lys Thr Ala Ser Thr Leu Glu Ala Ala Lys Leu Leu Lys 305 310 315 320 Glu Ile Ala Lys Leu Val Gly Cys Gin Val Glu Glu Ile Lys Gly Tyr 325 330 335 Arg Leu Asp Asn Lys Asp Lys Pro Asp Leu His Thr Phe Glu Pro Phe 340 345 350 Arg Lys Leu Lys Ser Asn Leu Thr Thr Ile Ala Val Glu Asn Leu Ser 355 360 365 Ile Thr Thr Leu Asp Thr Leu Ala His Ile Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Glu Glu Ala Ile Gin Lys Glu Leu Pro Asn Ile Phe 385 390 395 400 Ser Asp Glu Gin Ile Thr Gly Ile Ile Ala Val Arg Lys Lys Asn Ser 405 410 415 Gin Ile Phe Gly Lys Gly Trp His Ser Phe Ser Ile Lys Leu Met Lys 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr Ile 435 440 445 Page 3485 of 3790 Leu Ile Arg Leu Lys Lys Val Lys Thr Asn Ser Lys Ile Thr Asn Arg 450 455 460 Thr Lys Tyr Ile Asn Glu Gin Glu Val Thr Asp Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ser Lys Ser Ile Arg Gin Thr Val Lys Ile Ile Asn Ala Ala 485 490 495 Ile Lys Lys Tyr Gly Ala Phe Asp Gin Ile Val Ile Glu Met Pro Arg 500 505 510 Glu Ser Asn Glu Glu Asp Glu Arg Lys Phe Ile Ala Asp Leu Gin Lys 515 520 525 Ser Asn Ala Lys Glu Lys Asp Asp Ala Met Lys Gin Ala Ala Leu Leu 530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro His Gly Val Phe His Gly His Lys 545 550 555 560 Glu Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Ser Gly Lys His Ile Asp Ile His Asp Leu Ile His Asn Gin 580 585 590 His Met Phe Glu Ile Asp His Val Leu Pro Leu Ser Leu Ser Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ser Trp Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Phe Gin Ala Leu Pro Gin Met Ala Ser Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Arg Asp Tyr Ile Ser Lys Gin Lys Gly Ile 645 650 655 Ser Lys Lys Lys Arg Asp Tyr Leu Leu Thr Glu Gin Asp Ile Asn Lys 660 665 670 Val Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Val Ser Arg Val Val Leu Asn Thr Leu Gin Asp Ala Leu Lys Val 690 695 700 Page 3486 of 3790 Met Asn Lys Glu Thr Lys Ile Ser Val Ile Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg Gin Trp Arg Ile Asp Lys Ser Arg Glu Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg 740 745 750 Leu Trp Lys Lys Gin Asn Asn Pro Met Phe Ala Glu Asp Lys His Gly 755 760 765 Gin Lys Ile Asn Leu Asp Thr Gly Glu Val Leu Ser Asp Asp Ala Tyr 770 775 780 Lys Glu Leu Val Tyr Gin Ala Pro Tyr Gin Gly Phe Val Asn Thr Ile 785 790 795 800 Ser Ser Lys Ser Phe Glu Asp Glu Ile Leu Phe Ser Tyr Gin Val Asp 805 810 815 Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 820 825 830 Gin Ala Gin Leu Gly Lys Asp Lys Lys Glu Glu Thr Tyr Val Leu Gly 835 840 845 Lys Ile Lys Asp Ile Tyr Ser Gin Ala Gly Tyr Asp Ala Phe Arg Lys 850 855 860 Lys Tyr Asp Lys Asp Lys Ala Val Phe Leu Met Tyr Gin Lys Asp Pro 865 870 875 880 Glu Thr Trp Glu Lys Val Ile Glu Val Ile Leu Arg Asp Tyr Lys Glu 885 890 895 Leu Asp Asp Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg Tyr Lys 900 905 910 Val Lys His Gly Phe Val Arg Lys Tyr Ser Arg Lys Asn Lys Gly Thr 915 920 925 Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile 930 935 940 Asp Ile Thr Pro Asn Asn Ser Lys His Ser Val Val Leu Gin Ser Ile 1275 670 PRT Streptococcus oralis 1275 Met Ala Lys Phe Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Val 15 10 15 Ser Ser Val Gly Tyr Ala Val Val 20 Thr Glu Asp Tyr Arg Val 30 Pro Ala Phe Lys Phe Lys Val Leu Gly Asn Thr Glu Lys Glu Lys Ile Lys Lys Page 3488 of 3790 40 45 Asn Leu Ile Gly Ser Thr Thr Phe Val Pro Ala Gin Ser Ala Gin Gly 50 55 60 Thr Arg Val Phe Arg Val Asn Arg Arg Arg Ile Asp Arg Arg Asn His 65 70 75 80 Arg Ile Ala Tyr Leu Arg Asp Ile Phe Gin Lys Glu Ile Gly Lys Ile 85 90 95 Asp Lys Asn Phe Tyr Arg Arg Leu Asp Glu Ser Phe Arg Val Leu Gly 100 105 110 Asp Lys Ser Glu Asp Ile Gin Ile Lys Gin Pro Phe Phe Gly Asn Lys 115 120 125 Glu Leu Glu Thr Ala Tyr His Lys Lys Tyr Pro Thr Ile Tyr His Leu 130 135 140 Arg Lys His Leu Ala Asp Ala Asp Lys Asn Ser Pro Val Ala Asp Ile 145 150 155 160 Arg Glu Val Tyr Met Ala Leu Ser His Ile Phe Lys Tyr Arg Gly His 165 170 175 Phe Leu Thr Leu Gly Lys Ile Asp Pro Asn Asn Ile Asn Met Gin Asn 180 185 190 Ser Trp Ile Asp Phe Ile Glu Ser Cys Gin Asp Ala Phe Asp Leu Glu 195 200 205 Ile Ser Asp Glu Ser Lys Thr Ile Ala Ala Ile Phe Lys Ser Ser Asp 210 215 220 Asn Arg Gin Glu Lys Val Lys Gly Ile Leu Ser Tyr Phe Gin Pro Glu 225 230 235 240 Leu Ala Lys Lys Asp Lys Ser Ile Phe Lys Gin Leu Leu Gin Leu Leu 245 250 255 Phe Gly Leu Lys Thr Lys Phe Lys Glu Cys Phe Glu Leu Glu Glu Glu 260 265 270 Pro Asp Leu Asn Phe Ser Lys Glu Asn Tyr Asp Glu Asn Leu Glu Asn 275 280 285 Page 3489 of 3790 Leu Leu Gly Thr Leu Glu Glu Asp Phe Pro Asp Val Phe Ala Lys Leu 290 295 300 Lys Ile Leu Arg Asp Thr Ile Leu Leu Ser Asp Met Leu Thr Tyr Thr 305 310 315 320 Gly Ala Thr His Ala Arg Phe Ser Ala Thr Met Val Glu Arg Tyr Glu 325 330 335 Glu His Arg Lys Asp Leu Gin Arg Phe Lys Ser Phe Val Lys Gin Asn 340 345 350 Leu Ser Glu Gin Asp Tyr Leu Asp Ile Phe Gly Arg Lys Thr Pro Asn 355 360 365 Gly Phe Asp Val Asp Lys Glu Thr Lys Gly Tyr Val Gly Tyr Ile Ser 370 375 380 Asn Lys Met Val Leu Thr Asn Lys Gin Lys Thr Ile Gin Gin Asn Phe 385 390 395 400 Tyr Asp Tyr Ile Ser Gly Lys Ile Thr Gly Ile Glu Gly Ala Glu Tyr 405 410 415 Phe Leu Asn Lys Ile Ser Asp Gly Thr Phe Leu Arg Lys Leu Arg Thr 420 425 430 Thr Asp Asn Gly Thr Ile Pro Asn Gin Ile His Ala Tyr Glu Leu Glu 435 440 445 Lys Ile Ile Glu Arg Gin Gly Arg Asp Tyr Pro Phe Leu Leu Glu Asn 450 455 460 Lys Asp Lys Leu Leu Ser Ile Leu Thr Phe Lys Ile Pro Tyr Tyr Val 465 470 475 480 Gly Pro Leu Ala Lys Gly Asn Asn Ser Arg Phe Ala Trp Ile Lys Arg 485 490 495 Thr Thr Ser Gin Asp Val Leu Asp Asn Asn Asp Glu Asp Thr Lys Asn 500 505 510 Gly Lys Ile Arg Pro Trp Asn Tyr His Lys Leu Ile Asn Met Asp Glu 515 520 525 Thr Arg Asp Ala Phe Ile Thr Asn Leu Ile Gly Asn Asp Ile Ile Leu 530 535 540 Page 3490 of 3790 Page 3491 of 3790 Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Ile Pro Glu Asp Lys 100 105 110 Lys Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Ile Glu Glu Lys Glu 115 120 125 Tyr His Lys Gin Phe Pro Thr Ile Tyr His Leu Arg Lys Gin Leu Ala 130 135 140 Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 145 150 155 160 His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Asp Thr Phe Asp 165 170 175 Ile Lys Asn Asn Asp Ile Gin Lys Ile Phe Asn Glu Phe Ile Ser Ile 180 185 190 Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gin Asn Val Gin 195 200 205 Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 210 215 220 Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asp Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Arg Asp Thr Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Asp Phe Ala 275 280 285 Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Glu Arg Tyr Glu Asn His Gin Lys Asp Leu Ala Thr Leu 325 330 335 Lys Gin Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 340 345 350 Page 3492 of 3790 Ser Asp Gin Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 355 360 365 Thr Gin Glu Ser Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 370 375 380 Glu Gly Ala Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Leu Gin Glu Met Asn Ala Ile Leu Arg Arg Gin Gly Glu His Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 450 455 460 Trp Leu Thr Arg Asn Ser Asp Gin Ala Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met 485 490 495 Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Lys Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gin Phe Leu Asp Ser Arg 530 535 540 Gin Lys Lys Asp Ile Phe Tyr Thr Leu Phe Lys Ala Glu Asp Lys Arg 545 550 555 560 Lys Val Thr Glu Lys Asp Ile Ile Gin Tyr Leu His Thr Val Asp Gly 565 570 575 Tyr Asp Gly Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ala Ser 580 585 590 Leu Ser Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Page 3493 of 3790 595 600 605 Met Asp Asp Pro Asn Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr 610 615 620 Leu Thr Ile Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Gin 625 630 635 640 Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Lys Leu Ser Ser Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asp Lys Gin Thr Gly Lys Thr Ile Leu Asp Tyr Leu Met Asp Asp 675 680 685 Gly Tyr Asn Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Glu Leu 690 695 700 Ser Phe Lys Glu Ile Ile Lys Lys Ala Gin Val Val Gly Lys Thr Asp 705 710 715 720 Asp Val Lys Gin Val Val Gin Glu Leu Pro Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Ile Lys Leu Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly His Glu Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Ala Arg Gly Lys Lys Asn Ser Gin Gin Arg Tyr Lys Arg 770 775 780 Ile Glu Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ala Lys Ile 785 790 795 800 Leu Lys Glu His Pro Thr Asp Asn Ile Gin Leu Gin Asn Asp Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 820 825 830 Leu Asp Ile Asn Gin Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro 835 840 845 Page 3494 of 3790 Page 3495 of 3790 Page 3496 of 3790 1277 1371 PRT Streptococcus oralis 1277 Page 3497 of 3790 Ile Lys Asn Asn Asp Ile Gin Lys Ile Phe Ser Glu Phe Ile Ser Ile 180 185 190 Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gin Asn Ala Gin 195 200 205 Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 210 215 220 Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asp Leu Gly Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Asp Phe Ala 275 280 285 Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Glu Arg Tyr Glu Asn His Gin Lys Asp Leu Ala Val Leu 325 330 335 Lys Gin Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 340 345 350 Ser Asp Gin Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 355 360 365 Thr Gin Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 370 375 380 Glu Gly Thr Asp Tyr Phe Leu Glu Lys Ile Glu Arg Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Leu Gin Glu Met Asn Ala Ile Leu Arg Arg Gin Gly Glu His Tyr Pro 645 650 655 Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Cys Asp 660 665 670 Page 3499 of 3790 Lys Gin Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Lys 675 680 685 Asn Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu Ser Phe 690 695 700 Lys Glu Ile Thr Gin Lys Ala Gin Val Val Gly Lys Thr Asp Asp Val 705 710 715 720 Lys Gin Val Val Gin Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 His Thr Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr 755 760 765 Thr Ala Arg Gly Lys Lys Asn Ser Gin Gin Arg Tyr Lys Arg Ile Glu 770 775 780 Asp Ala Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile Leu Lys 785 790 795 800 Glu His Pro Thr Asn Asn Ile Gin Leu Gin Asn Asp Arg Leu Phe Leu 805 810 815 Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro Leu Asp 820 825 830 Ile Asn Gin Leu Ser Ser Tyr Asp Ile Asp His Ile Val Pro Gin Ala 835 840 845 Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Leu Lys 850 855 860 Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val Val Gin 865 870 875 880 Lys Arg Lys Ala Phe Trp Gin Gin Leu Leu Asp Ser Lys Leu Ile Ser 885 890 895 Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 900 905 910 Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg 915 920 925 Page 3500 of 3790 Page 3501 of 3790 Gly Glu Asp 1370 1278 1121 PRT Streptococcus oralis Page 3502 of 3790 1278 Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 15 10 15 Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Ile His Ala Asn Ser 20 25 30 Arg Leu Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 35 40 45 Asn Arg Gin Ala Arg Arg Leu Asn Arg Arg Lys Lys His Arg Gly Val 50 55 60 Arg Phe Gin Asp Leu Phe Glu Asp Tyr Gly Leu Leu Thr Asp Phe Ser 65 70 75 80 Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 85 90 95 Asn Gin Gin Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 100 105 110 Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 115 120 125 Gly Ala Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 130 135 140 Leu Leu Ala Glu Gin Thr Pro Gly Gin Ile Gin Leu Glu Arg Phe Glu 145 150 155 160 Lys Tyr Gly Gin Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 165 170 175 Lys Cys Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 180 185 190 Ala Glu Lys Ile Leu Arg Lys Gin Gin Glu Phe Asn Asn Gin Ile Thr 195 200 205 Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Val Leu Ile Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Ile Asn Glu Ala Thr 485 490 495 Page 3504 of 3790 Lys Lys His Gly Ile Phe Asp Asn Ile Val Ile Glu Met Ala Arg Glu 500 505 510 Asn Asn Glu Glu Asp Ala Lys Lys Asp Tyr Ile Lys Arg Gin Lys Ala 515 520 525 Asn Gin Asp Glu Lys Asn Ala Ala Met Glu Lys Ala Ala Phe Gin Tyr 530 535 540 Asn Gly Lys Lys Glu Leu Pro Gly Asn Ile Phe Asn Gly His Lys Glu 545 550 555 560 Leu Ala Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Lys Cys Leu 565 570 575 Tyr Thr Gly Lys Thr Ile Pro Ile Ser Asp Leu Ile His Asn Gin Tyr 580 585 590 Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 595 600 605 Ser Leu Ser Asn Lys Val Leu Val His Ala Thr Ala Asn Gin Glu Lys 610 615 620 Gly Gin Arg Thr Pro Phe Gin Ala Leu Asp Ser Met Asp Asp Ala Trp 625 630 635 640 Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Asp Leu Lys Ser Leu Ser 645 650 655 Asn Lys Lys Lys Asp Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 660 665 670 Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 675 680 685 Ser Ser Arg Val Val Leu Asn Ala Leu Gin Asp Phe Tyr Lys Ser His 690 695 700 Gin Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gin Phe Thr Ser Gin 705 710 715 720 Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 725 730 735 His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg Leu 740 745 750 Page 3505 of 3790 Page 3506 of 3790 1279 1134 PRT Streptococcus oralis 1279 Met Asn Gly Leu Val Leu Gly Leu Asp Ile Gly Ile Ala Ser Val Gly 15 10 15 Val Gly Ile Leu Glu Lys Asn Ser Gly Lys Ile Val His Ala Ser Ser 20 25 30 Arg Ile Phe Pro Ala Ala Thr Ala Asp Asn Asn Val Glu Arg Arg Lys 35 40 45 Asn Arg Gin Ala Arg Arg Leu His Arg Arg Lys Lys His Arg Gly Ala 50 55 60 Arg Leu Lys Asp Leu Phe Glu Tyr Tyr Gly Leu Leu Thr Asp Phe Ser 65 70 75 80 Lys Val Ser Ile Asn Leu Asn Pro Tyr Arg Leu Arg Val Asp Gly Leu 85 90 95 Page 3507 of 3790 Asp Gin Gin Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 100 105 110 Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 115 120 125 Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 130 135 140 Leu Leu Ala Glu Gin Thr Pro Gly Gin Ile Gin Leu Glu Arg Phe Glu 145 150 155 160 Lys Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Val Glu Asn Ser Glu 165 170 175 Lys Cys Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Lys Lys Glu 180 185 190 Ala Glu Arg Ile Leu Arg Lys Gin Gin Glu Phe Asn Asn Gin Ile Thr 195 200 205 Asp Glu Phe Ile Glu Asp Tyr Leu Lys Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Phe Arg Thr Asp Gly Ala Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asn Glu Tyr Arg Ala Ser Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Lys Thr Ile 290 295 300 Ile Glu Tyr Ala Lys Ser Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 305 310 315 320 Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gin Ile Arg Gly 325 330 335 Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 565 570 575 Tyr Thr Gly Lys Ser Ile Pro Ile Ser Asp Leu Ile His Asn Gin Tyr 580 585 590 Page 3509 of 3790 Lys Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Ser Phe Asp Asp 595 600 605 Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gin Glu Lys 610 615 620 Gly Gin Arg Thr Pro Phe Gin Ala Leu Asp Ser Met Asp Asp Ala Trp 625 630 635 640 Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Glu Ser Lys Leu Leu Gly 645 650 655 Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 660 665 670 Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg Tyr 675 680 685 Ser Ser Arg Val Val Leu Asn Ala Leu Gin Asp Phe Tyr Lys Asn His 690 695 700 Asn Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gin Phe Thr Ser Gin 705 710 715 720 Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 725 730 735 His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg Leu 740 745 750 Trp Lys Lys Gin Asn Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gin Phe 755 760 765 Val Asp Ser Gin Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 770 775 780 Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 785 790 795 800 Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp 805 810 815 Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 820 825 830 Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 835 840 845 Page 3510 of 3790 Lys Ile Lys Asp Ile Tyr Ser Leu 850 855 Gly Thr Lys Thr Pro Ser Lys Thr 860 Gly Phe Tyr Lys Phe Leu Asp Leu 865 870 Tyr Asn Lys Asp Lys Ser Gin Phe 875 880 Leu Met Phe Gin Lys Asp Arg Lys 885 Thr Trp Asp Glu Val Ile Glu Lys 890 895 Ile Met Glu Gin Tyr Arg Pro Phe 900 Lys Glu Tyr Asp Lys Ala Gly Lys 905 910 Leu Val Asp Phe Asn Pro Phe Glu 915 920 Lys Tyr Arg Gin Glu Asn Gly Pro 925 Ile Arg Lys Tyr Ser Lys Lys Gly 930 935 Asn Gly Pro Glu Ile Lys Ser Leu 940 Lys Tyr Tyr Asp Ile Leu Leu Gly 945 950 Lys His Lys Asn Ile Thr Pro Glu 955 960 Gly Ser Arg Asn Thr Val Ala Leu 965 Leu Ser Leu Asn Pro Trp Arg Thr 970 975 Asp Val Tyr Tyr Asn Met Glu Thr 980 Lys Lys Tyr Glu Phe Leu Gly Leu 985 990 Lys Tyr Ala Asp Leu Pro Phe Glu 995 1000 Glu Gly Gly Ala Tyr Gly Ile Ser Page 3511 of 3790 1280 550 PRT Streptococcus oralis 1280 Page 3512 of 3790 Ala Tyr Pro Lys Leu Ala Pro Glu Leu Ile Tyr Gly His His Ala His 180 185 190 Phe Asn Arg His Glu Glu Asn Lys Ala Thr Ile Arg Lys Tyr Leu Tyr 195 200 205 Ser Asn Ile Met Arg Phe Phe Asn Asn Pro Asp Ser Lys Val Ser Lys 210 215 220 Asp Ile Trp Asp Cys Asn Arg Asp Leu Pro Ile Ile Lys Asp Ile Ile 225 230 235 240 Tyr Asn Ser Gin Val Asn Phe Val Lys Arg Thr Met Ile Lys Lys Gly 245 250 255 Ala Phe Tyr Asn Gin Asn Pro Val Gly Lys Phe Asn Lys Gin Ile Ala 260 265 270 Ala Asn Asn Arg Tyr Pro Leu Lys Thr Lys Val Ser Ser Leu Asp Thr 275 280 285 Ser Ile Tyr Gly Gly Tyr Gly Pro Met Asn Ser Ala Leu Ser Ile Ile 290 295 300 Ile Ile Ala Glu Arg Phe Asn Glu Lys Lys Cys Lys Ile Glu Thr Val 305 310 315 320 Lys Glu Phe His Asp Ile Phe Ile Ile Asp Tyr Lys Lys Phe Asn Asn 325 330 335 Asp Pro Phe Gin Phe Leu Asn Asp Thr Ser Glu Asn Gly Phe Leu Lys 340 345 350 Lys Asn Asn Ile Asn Arg Val Leu Ala Phe Tyr Arg Val Pro Lys Tyr 355 360 365 Ser Leu Met Gin Lys Ile Asp Gly Thr Arg Met Leu Phe Glu Ser Lys 370 375 380 Ser Asn Leu His Lys Ala Thr Gin Phe Lys Leu Thr Lys Thr Gin Asn 385 390 395 400 Glu Leu Phe Phe His Met Arg Arg Leu Leu Thr Lys Ser Asn Leu Met 405 410 415 Asp Leu Lys Ser Glu Ser Ala Ile Lys Glu Ser Gin Asn Phe Ile Leu 545 550 1281 1140 PRT Streptococcus parasanguinis 1281 Lys Val Ser Ile Asn Leu Asn Pro Tyr Gin Leu Arg Val Gin Gly Leu Page 3515 of 3790 Val Asp Gin Ile His Gly Tyr Arg Ile Asp Pro Asn Lys Lys Pro Glu 340 345 350 Met His Thr Phe Glu Thr Tyr Arg Lys Met Gin Ser Leu Glu Thr Ile 355 360 365 Ser Val Glu Glu Leu Pro Arg Lys Val Leu Asp Glu Leu Ala His Ile 370 375 380 Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Glu Glu Ala Ile Asn Ala 385 390 395 400 Thr Leu Lys Asp Thr Phe Ser Gin Asp Gin Val Leu Glu Leu Val Gin 405 410 415 Phe Arg Lys Asn Asn Ser Ser Leu Phe Ser Lys Gly Trp His Ser Phe 420 425 430 Ser Leu Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser 435 440 445 Glu Glu Gin Met Thr Ile Leu Thr Arg Leu Gly Lys Gin Lys Ser Lys 450 455 460 Glu Thr Ser Lys Arg Thr Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu 465 470 475 480 Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys 485 490 495 Ile Ile Asn Glu Ala Thr Lys Lys Tyr Gly Ile Phe Asp Asn Ile Val 500 505 510 Ile Glu Met Ala Arg Glu Asn Asn Glu Glu Asp Ala Lys Lys Glu Tyr 515 520 525 Ile Lys Arg Gin Lys Ala Asn Leu Asp Glu Lys Asn Ala Ala Met Glu 530 535 540 Lys Ala Ala Phe Gin Tyr Asn Gly Lys Lys Glu Leu Pro Asp Asn Val 545 550 555 560 Phe His Gly His Lys Glu Leu Ala Thr Lys Ile Arg Leu Trp His Gin 565 570 575 Gin Gly Glu Lys Cys Leu Tyr Thr Gly Lys Asn Ile Pro Ile Ser Asp 580 585 590 Page 3516 of 3790 Leu Ile Gin Asn Gin Tyr Lys Tyr Glu Ile Asp His Ile Leu Pro Leu 595 600 605 Ser Leu Ser Phe Asp Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala 610 615 620 Thr Ala Asn Gin Glu Lys Gly Gin Arg Thr Pro Phe Gin Ala Leu Asp 625 630 635 640 Ser Met Asp Asp Ala Trp Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys 645 650 655 Asp Ser Lys Leu Leu Gly Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu 660 665 670 Glu Asp Ile Ser Lys Ile Glu Val Lys Gin Lys Phe Ile Glu Arg Asn 675 680 685 Leu Val Asp Thr Arg Tyr Ser Ser Arg Val Val Leu Asn Ala Leu Gin 690 695 700 Asp Phe Tyr Lys Glu His Gin Phe Asp Thr Thr Ile Ser Val Val Arg 705 710 715 720 Gly Gin Phe Thr Ser Gin Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser 725 730 735 Arg Glu Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala Ala 740 745 750 Ser Ser Gin Leu Arg Leu Trp Lys Lys Gin Asn Asn Pro Leu Ile Ser 755 760 765 Tyr Thr Glu Gly Gin Phe Val Asp Gin Val Thr Gly Glu Ile Ile Ser 770 775 780 Leu Ser Asp Asp Glu Tyr Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp 785 790 795 800 His Phe Val Asp Thr Leu Lys Ser Lys Lys Phe Glu Asp Ser Ile Leu 805 810 815 Phe Ser Tyr Gin Val Asp Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala 820 825 830 Thr Ile Tyr Ala Thr Arg Lys Ala Lys Leu Asp Lys Glu Asn Lys Glu 835 840 845 Page 3517 of 3790 Arg Phe Glu Lys Gly Glu Glu Leu Glu Val Leu Gly Lys Val Pro 1282 1374 PRT Streptococcus pseudoporcinus 1282 Met Lys Lys Arg Tyr Ser Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 15 10 15 Ser Val Gly Trp Ala Val Ile Asn Glu Asp Tyr Lys Val Pro Ala Lys 20 25 30 Lys Met Thr Val Phe Gly Asn Thr Asp Arg Lys Thr Ile Lys Lys Asn 35 40 45 Leu Leu Gly Thr Val Leu Phe Asp Ser Gly Glu Thr Ala Gin Ala Arg 50 55 60 Arg Leu Lys Arg Thr Asn Arg Arg Arg Tyr Thr Arg Arg Arg Tyr Arg 65 70 75 80 Leu Cys Gin Leu Gin Asn Ile Phe Ala Thr Glu Met Val Lys Val Asp 85 90 95 Asp Thr Phe Phe Gin Arg Leu Ser Glu Ser Phe Phe Tyr Tyr Gin Asp 100 105 110 Lys Ala Phe Asp Lys His Pro Ile Phe Gly Asn Ser Lys Glu Glu Arg 115 120 125 Ala Tyr His Lys Thr Tyr Pro Thr Ile Tyr His Leu Arg Lys Asp Leu 130 135 140 Ala Asp Arg Asp Gin Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 145 150 155 160 Ser His Ile Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Lys Leu Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile 405 410 415 Page 3520 of 3790 His Leu Lys Glu Leu His Ala Ile Leu Arg Arg Gin Glu Lys Tyr Tyr 420 425 430 Pro Phe Leu Ala Glu Gin Lys Glu Lys Ile Glu Gin Leu Leu Cys Phe 435 440 445 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Lys Gly Gly Asn Ser Ser 450 455 460 Phe Ala Trp Leu Lys Arg Arg Ser Asp Glu Pro Ile Thr Pro Trp Asn 465 470 475 480 Phe Lys Asp Val Val Asp Glu Glu Ala Ser Ala Gin Ala Phe Ile Glu 485 490 495 Gly Met Thr Asn Tyr Asp Thr Tyr Leu Pro Glu Glu Lys Val Leu Pro 500 505 510 Lys His Ser Pro Leu Tyr Glu Met Phe Thr Val Tyr Asn Glu Leu Thr 515 520 525 Lys Val Lys Tyr Ile Ala Glu Asn Met Thr Lys Pro Leu Tyr Leu Ser 530 535 540 Ala Glu Gin Lys Glu Ala Ile Ile Asp His Leu Phe Lys Gin Thr Arg 545 550 555 560 Lys Val Thr Val Lys Asp Leu Lys Glu Lys Tyr Phe Ser Gin Ile Glu 565 570 575 Gly Leu Glu Asn Val Asp Val Thr Gly Val Glu Gly Ala Phe Asn Ala 580 585 590 Ser Leu Gly Thr Tyr Asn Asp Leu Leu Lys Ile Ile Lys Asp Lys Ala 595 600 605 Phe Leu Asp Asp Glu Ala Asn Ala Glu Ile Leu Glu Glu Ile Val Leu 610 615 620 Ile Leu Thr Leu Phe Gin Asp Glu Lys Leu Ile Glu Lys Arg Leu Ala 625 630 635 640 Lys Tyr Ala Asn Leu Phe Glu Lys Ser Val Leu Lys Lys Leu Arg Lys 645 650 655 Arg His Tyr Arg Gly Trp Gly Arg Leu Ser Arg Gin Leu Ile Asp Gly 660 665 670 Page 3521 of 3790 Met Lys Asp Lys Ala Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ala 675 680 685 Asp Asp Phe Ala Asn Arg Asn Phe Ile Gin Leu Ile Asn Asp Ser Ser 690 695 700 Leu Asp Phe Glu Lys Leu Ile Asp Asp Ala Gin Lys Lys Ala Ile Lys 705 710 715 720 Arg Glu Ser Leu Thr Glu Ala Val Ala Asn Leu Ala Gly Ser Pro Ala 725 730 735 Ile Lys Lys Gly Ile Leu Gin Ser Leu Lys Val Val Asp Glu Ile Val 740 745 750 Lys Val Met Gly His Asn Pro Asp Asn Ile Val Ile Glu Met Ser Arg 755 760 765 Glu Asn Gin Thr Thr Ala Gin Gly Leu Lys Asn Ala Arg Gin Arg Leu 770 775 780 Lys Lys Ile Lys Glu Val His Lys Lys Thr Gly Ser Arg Ile Leu Glu 785 790 795 800 Asp Asn Ser Glu Arg Ile Thr Asn Leu Thr Leu Gin Asp Asn Arg Leu 805 810 815 Tyr Leu Tyr Leu Leu Gin Asp Gly Lys Asp Met Tyr Thr Gly Gin Asp 820 825 830 Leu Asp Ile Asn Asn Leu Ser Gin Tyr Asp Ile Asp His Ile Ile Pro 835 840 845 Gin Ser Phe Ile Lys Asp Asn Ser Ile Asp Asn Leu Val Leu Thr Thr 850 855 860 Gin Lys Ala Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Ile Glu Val 865 870 875 880 Val Arg Asp Met Lys Asp Arg Val Trp Arg Arg Gin Leu Ala Asn Gly 885 890 895 Ala Ile Ser Arg Gin Lys Phe Asp His Leu Thr Lys Ala Glu Arg Gly 900 905 910 Gly Leu Ala Asp Ser Asp Lys Ala Arg Phe Leu Arg Arg Gin Leu Val 915 920 925 Page 3522 of 3790 Lys Ala Gin Lys Leu Lys Thr Val Lys Glu Ile Val Gly Ile Thr 1283 1052 PRT Streptococcus pyogenes 1370 Page 3524 of 3790 1283 Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu 15 10 15 Thr Leu Leu Lys Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys 20 25 30 Glu Ile Phe Phe Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 35 40 45 Gly Gly Ala Ser Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 50 55 60 Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu 65 70 75 80 Asp Leu Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His 85 90 95 Gin Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp 100 105 110 Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 115 120 125 Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 130 135 140 Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 145 150 155 160 Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile 165 170 175 Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 180 185 190 Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 195 200 205 Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 210 215 220 Ser Gly Glu Gin Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 225 230 235 240 Page 3525 of 3790 Arg Lys Val Thr Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile 245 250 255 Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 260 265 270 Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 275 280 285 Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 290 295 300 Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 305 310 315 320 Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys 325 330 335 Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 340 345 350 Gly Ile Arg Asp Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 355 360 365 Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp 370 375 380 Ser Leu Thr Phe Lys Glu Asp Leu Gin Lys Ala Gin Val Ser Gly Gin 385 390 395 400 Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 405 410 415 Ile Lys Lys Gly Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val 420 425 430 Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala 435 440 445 Arg Glu Asn Gin Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg 450 455 460 Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu 465 470 475 480 Lys Glu Tyr Pro Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr 485 490 495 Page 3526 of 3790 Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu 500 505 510 Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin 515 520 525 Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser 530 535 540 Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 545 550 555 560 Lys Lys Met Lys Asn Tyr Trp Lys Gin Leu Leu Asn Ala Lys Leu Ile 565 570 575 Thr Gin Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 580 585 590 Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr 595 600 605 Arg Gin Ile Thr Lys His Val Ala Gin Ile Leu Asp Ser Arg Met Asn 610 615 620 Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile 625 630 635 640 Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gin Phe 645 650 655 Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr 660 665 670 Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu 675 680 685 Glu Ser Glu Phe Val Tyr Gly Asp Tyr Lys Val Tyr Asp Ile Arg Lys 690 695 700 Met Ile Ala Lys Ser Glu Gin Glu Ile Gly Lys Ala Thr Ala Lys Tyr 705 710 715 720 Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu 725 730 735 Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu 740 745 750 Page 3527 of 3790 Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg 755 760 765 Lys Val Leu Ser Met Pro Gin Val Asn Ile Val Lys Lys Thr Glu Val 770 775 780 Gin Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser 785 790 795 800 Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly 805 810 815 Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys 820 825 830 Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Val 835 840 845 Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asp Pro Val Asp 850 855 860 Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Arg Lys Asp Leu Ile Ile 865 870 875 880 Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg 885 890 895 Met Leu Ala Ser Ala Gly Glu Leu Gin Lys Gly Asn Glu Leu Ala Leu 900 905 910 Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys 915 920 925 Leu Lys Gly Ser Pro Glu Asp Asn Glu Gin Lys Gin Leu Phe Val Glu 930 935 940 Gin His Lys His Tyr Leu Asp Glu Ile Ile Glu Gin Ile Ser Glu Phe 945 950 955 960 Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser 965 970 975 Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gin Ala Glu Asn 980 985 990 Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Page 3528 of 3790 995 1000 1005 1284 1368 PRT Streptococcus pyogenes 1284 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Page 3530 of 3790 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Page 3531 of 3790 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Ile Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 850 855 860 Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 865 870 875 880 Asn Tyr Trp Arg Gin Leu Leu Asn Ala Lys Leu Ile Thr Gin Arg Lys 885 890 895 Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 900 905 910 Lys Ala Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg Gin Ile Thr 915 920 925 Page 3532 of 3790 Ser Val Lys Glu Leu Leu Gly Leu Thr Ile Met Glu Arg Ser Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Page 3535 of 3790 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Page 3536 of 3790 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Ala Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Gly Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly His Ser Leu 705 710 715 720 His Glu Gin Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr 755 760 765 Page 3537 of 3790 Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys 1286 1368 PRT Streptococcus pyogenes 1286 Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 20 25 30 Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 50 55 60 Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 85 90 95 Page 3540 of 3790 Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 100 105 110 His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 115 120 125 His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 130 135 140 Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 165 170 175 Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gin Leu Val Gin Thr Tyr 180 185 190 Asn Gin Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 195 200 205 Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 210 215 220 Leu Ile Ala Gin Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 225 230 235 240 Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 245 250 255 Asp Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Thr Tyr Asp 260 265 270 Asp Asp Leu Asp Asn Leu Leu Ala Gin Ile Gly Asp Gin Tyr Ala Asp 275 280 285 Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 290 295 300 Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 305 310 315 320 Met Ile Lys Arg Tyr Asp Glu His His Gin Asp Leu Thr Leu Leu Lys 325 330 335 Ala Leu Val Arg Gin Gin Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 340 345 350 Page 3541 of 3790 Asp Gin Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 355 360 365 Gin Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 370 375 380 Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gly Glu Leu His Ala Ile Leu Arg Arg Gin Glu Asp Phe Tyr Pro Phe 420 425 430 Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 450 455 460 Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Gly Ala Ser Ala Gin Ser Phe Ile Glu Arg Met Thr 485 490 495 Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gin 530 535 540 Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 545 550 555 560 Val Lys Gin Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 565 570 575 Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 595 600 605 Page 3542 of 3790 Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 625 630 635 640 His Leu Phe Asp Asp Lys Val Met Lys Gin Leu Lys Arg Arg Arg Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 660 665 670 Lys Gin Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 675 680 685 Ala Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ser Leu Thr Phe 690 695 700 Lys Glu Asp Ile Gin Lys Ala Gin Val Ser Gly Gin Gly Asp Ser Leu 705 710 715 720 His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gin 755 760 765 Thr Thr Gin Lys Gly Gin Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 770 775 780 Glu Glu Gly Ile Lys Glu Leu Gly Ser Gin Ile Leu Lys Glu His Pro 785 790 795 800 Val Glu Asn Thr Gin Leu Gin Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 805 810 815 Gin Asn Gly Arg Asp Met Tyr Val Asp Gin Glu Leu Asp Ile Asn Arg 820 825 830 Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gin Ser Phe Leu Lys 835 840 845 Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 980 985 990 Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 995 1000 1005 Page 3544 of 3790 Page 3545 of 3790 Thr Lys Glu Val Leu Asp Ala 1340 1345 Thr Leu Ile His Gin Ser Ile Thr 1350 Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gin Leu Gly Gly Asp 1355 1360 1365 1287 1370 PRT Streptococcus ratti 1287 Page 3546 of 3790 Tyr Asp Val Thr Gin Glu Asp Ser His Leu Ala Asp Val Lys Ile Asn 195 200 205 Ile Ser Asp Ile Ile Thr Glu Lys Met Asn Lys Ser Arg Lys Val Glu 210 215 220 Ala Leu Leu Phe His Phe Pro Ser Gin Lys Lys Asn Ser Phe Phe Gly 225 230 235 240 Asn Leu Val Ser Leu Val Phe Gly Leu Leu Pro Asn Phe Lys Thr Asn 245 250 255 Phe Asn Leu Ala Glu Asp Ala Lys Leu Gin Leu Ser Lys Asp Ser Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Glu Tyr Thr 275 280 285 Asp Val Phe Val Ala Ala Arg Lys Leu Tyr Asp Ser Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Asn Asp Leu Ser Thr Lys Ala Ile Leu Ser Ala 305 310 315 320 Ser Met Val Arg Arg Tyr Glu Glu His Asn Lys Asp Leu Ala Lys Leu 325 330 335 Lys Ala Phe Val Lys Ala Asn Phe Thr His Asp Val Phe Lys Glu Val 340 345 350 Phe Ser Asp Ala Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Glu Gly Lys 355 360 365 Thr Ser Gin Glu Asp Phe Tyr Lys Tyr Val Lys Asn Leu Ile Gly Lys 370 375 380 Val Asp Gly Ser Ala Asp Phe Ile Glu Lys Ile Asp Arg Glu Asp Phe 385 390 395 400 Leu Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Val 405 410 415 His Leu Ala Glu Met Lys Ala Ile Leu Arg Arg Gin Gly Glu Tyr Tyr 420 425 430 Pro Phe Leu Lys Glu His Ala Glu Lys Ile Gin Gin Ile Leu Thr Phe 435 440 445 Page 3547 of 3790 Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asp Arg His Gly His Ser Asp 450 455 460 Phe Ala Trp Ala Ser Phe Asn Ser Glu Glu Lys Val Thr Pro Trp Asn 465 470 475 480 Phe Glu Glu Ile Ile Asp Lys Asn Lys Ser Ala Gin Ala Phe Ile Glu 485 490 495 Arg Met Thr Asn Gin Asp Leu Tyr Leu Pro Asn Glu Lys Val Leu Pro 500 505 510 Lys His Ser Pro Leu Tyr Glu Lys Tyr Thr Val Tyr Asn Glu Leu Thr 515 520 525 Lys Ile Lys Tyr Val Thr Glu Thr Gly Thr Ala Lys Phe Phe Asp Ala 530 535 540 Asn Leu Lys Gin Glu Ile Phe Asp Gly Leu Phe Lys Lys Glu Arg Lys 545 550 555 560 Val Thr Lys Arg Lys Leu Leu Thr Phe Leu Glu Lys Asn Phe Asp Glu 565 570 575 Phe Arg Ile Val Asp Ile Gin Gly Leu Asp Lys Glu Thr Glu Thr Phe 580 585 590 Asn Ala Ser Tyr Gly Ile Tyr Gin Asp Leu Leu Lys Ile Ile Lys Asp 595 600 605 Lys Ala Phe Met Asp Asp Ser Glu Asn Ala Asp Ile Leu Glu Asp Ile 610 615 620 Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Lys Gin Arg 625 630 635 640 Leu Ala Lys Tyr Ala Asp Leu Phe Asp Lys Lys Val Ile Asp Asn Leu 645 650 655 Ala Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Leu 660 665 670 Asn Gly Ile Arg Asp Lys Arg Ser Arg Lys Thr Ile Met Asp Tyr Leu 675 680 685 Val Asp Asp Gly Arg Ser Asn Arg Asn Leu Met Gin Leu Ile Thr Asp Page 3549 of 3790 Page 3550 of 3790 Glu Asp 1370 1288 1135 PRT Streptococcus salivarius 1288 Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 15 10 15 Page 3551 of 3790 Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 20 25 30 Arg Ile Phe Pro Ala Ala Gin Ala Glu Asn Asn Leu Glu Arg Arg Thr 35 40 45 Asn Arg Gin Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 50 55 60 Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 65 70 75 80 Lys Val Ser Ile Asn Leu Asn Pro Tyr Gin Leu Arg Val Lys Gly Leu 85 90 95 Thr Ala Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 100 105 110 Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 115 120 125 Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser Lys 130 135 140 Gin Leu Glu Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Tyr Gin 145 150 155 160 Lys Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Arg 165 170 175 Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr His Ala Glu 180 185 190 Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Pro Gin Ile Thr 195 200 205 Asp Glu Phe Ile Asn Ser Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Lys 225 230 235 240 Tyr Thr Thr Lys Lys Asp Ala Gin Gly Gin Tyr Ile Thr Leu Asn Asn 245 250 255 Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 260 265 270 Page 3552 of 3790 Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn 275 280 285 Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 290 295 300 Glu Gin Lys Tyr Gin Ile Ile Thr Tyr Val Lys Asn Glu Lys Ala Met 305 310 315 320 Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ala Cys Asp 325 330 335 Ile Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 340 345 350 Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Glu Thr Ile 355 360 365 Asp Ile Glu Gin Ile Glu Arg Glu Lys Leu Asp Lys Leu Ala Tyr Val 370 375 380 Leu Thr Leu Asn Thr Glu Arg Glu Gly Ile Gin Glu Ala Leu Asp His 385 390 395 400 Glu Phe Ala Asp Gly Thr Phe Ser Gin Glu Gin Val Asp Glu Leu Val 405 410 415 Gin Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Ser 420 425 430 Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 435 440 445 Ser Glu Glu Gin Met Thr Ile Leu Thr Arg Leu Gly Lys Gin Lys Thr 450 455 460 Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Gin Leu Thr 465 470 475 480 Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gin Ala Ile 485 490 495 Lys Ile Val Asn Ala Ala Ile Lys Lys Tyr Gly Asp Phe Asp Asn Ile 500 505 510 Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Page 3553 of 3790 515 520 525 Ile Gin Lys Ile Gin Lys Ala Asn Lys Ala Glu Lys Asp Ala Ala Met 530 535 540 Arg Lys Ala Ala Asn Gin Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 545 550 555 560 Val Phe His Gly His Lys Gin Leu Ala Thr Lys Ile Arg Leu Trp His 565 570 575 Gin Gin Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 580 585 590 Asp Leu Ile Asn Asn Pro Asn Gin Phe Glu Ile Asp His Ile Leu Pro 595 600 605 Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 610 615 620 Ala Thr Ala Asn Gin Glu Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu 625 630 635 640 Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 645 650 655 Arg Glu Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 660 665 670 Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 675 680 685 Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 690 695 700 Gin Glu His Phe Lys Ala His Lys Ile Asp Thr Lys Val Ser Val Val 705 710 715 720 Arg Gly Gin Phe Thr Ser Gin Leu Arg Arg His Trp Gly Ile Asp Lys 725 730 735 Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 740 745 750 Ala Ser Ser Gin Leu Asn Leu Trp Lys Lys Gin Lys Asn Thr Leu Val 755 760 765 Page 3554 of 3790 Gly Thr Tyr Arg Ile Ser Glu Glu Lys Tyr Asn Asp Ile Lys Lys 1010 1015 1020 Page 3555 of 3790 1130 1135 1289 1127 PRT Streptococcus salivarius 1289 Page 3556 of 3790 Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 100 105 110 Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 115 120 125 Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser Lys 130 135 140 Gin Leu Glu Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Tyr Gin 145 150 155 160 Lys Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Lys 165 170 175 Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ala Glu 180 185 190 Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Pro Gin Ile Thr 195 200 205 Asp Glu Phe Ile Asn Ser Tyr Leu Gin Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Thr Thr Lys Lys Asp Ser Glu Asp Glu Tyr Ile Thr Leu Asp Asn 245 250 255 Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 260 265 270 Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn 275 280 285 Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 290 295 300 Glu Gin Lys Asn Gin Ile Ile Thr Asn Val Lys Asn Glu Lys Ala Met 305 310 315 320 Gly Pro Ala Lys Leu Phe Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp 325 330 335 Val Ala Asp Ile Lys Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu 340 345 350 Page 3557 of 3790 Ile His Thr Phe Glu Ala Tyr Arg Lys Met Lys Thr Leu Ala Thr Ile 355 360 365 Asp Ile Glu Gin Met Glu Arg Glu Asn Leu Asp Lys Leu Ala Tyr Val 370 375 380 Leu Thr Leu Asn Thr Glu Lys Glu Gly Ile Gin Glu Ala Leu Glu His 385 390 395 400 Glu Phe Ala Asp Gly Thr Phe Ser Gin Glu Gin Ile Asp Glu Leu Val 405 410 415 Gin Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp His Ser 420 425 430 Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr 435 440 445 Ser Glu Glu Gin Met Thr Ile Leu Thr Arg Leu Gly Lys Gin Lys Thr 450 455 460 Thr Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Gin Leu Thr 465 470 475 480 Glu Glu Ile Tyr Asn Pro Val Ala Ala Lys Ser Val Arg Gin Ala Ile 485 490 495 Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 500 505 510 Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 515 520 525 Ile Gin Lys Ile Gin Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 530 535 540 Leu Lys Ala Ala Asn Gin Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 545 550 555 560 Val Phe His Gly His Lys Gin Leu Ala Thr Lys Ile Arg Leu Trp His 565 570 575 Gin Gin Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 580 585 590 Asp Leu Ile Asn Asn Ser Asn Gin Phe Glu Ile Asp His Ile Leu Pro Page 3558 of 3790 595 600 605 Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 610 615 620 Ala Thr Ala Asn Gin Glu Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu 625 630 635 640 Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 645 650 655 Arg Asp Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 660 665 670 Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 675 680 685 Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 690 695 700 Gin Glu His Phe Arg Val His Lys Thr Asp Thr Lys Val Ser Val Val 705 710 715 720 Arg Gly Gin Phe Thr Ser Gin Leu Arg Arg His Trp Gly Ile Glu Lys 725 730 735 Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 740 745 750 Ala Ser Ser Gin Leu Asn Leu Trp Lys Lys Gin Lys Asn Thr Leu Val 755 760 765 Ser Tyr Ser Glu Asp Gin Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 770 775 780 Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gin His 785 790 795 800 Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 805 810 815 Ser Tyr Gin Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 820 825 830 Ile Tyr Ala Thr Arg Gin Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 835 840 845 Page 3559 of 3790 Ile Val Ala Lys Gly Gly Gin Cys Lys Lys Gly Val Ser Lys Pro 1085 1090 1095 Page 3560 of 3790 Asn Ile Ser Ile Tyr Lys 1100 Ile 1105 Arg Thr Asp Val Leu Gly Asn Gin 1110 His Ile Ile Lys Asn Glu Gly Asp Lys Pro Lys Leu Asp Phe 1115 1120 1125 1290 1385 PRT Streptococcus salivarius Page 3561 of 3790 Asn Ala Ile Phe Glu Ser Asp Leu 195 200 Ser Leu Glu Asn Ser Lys Gin Leu 205 Glu Glu Ile Val Lys Asp Lys Ile 210 215 Ser Lys Ser Ala Lys Lys Asp Arg 220 Ile Leu Lys Leu Phe Pro Gly Glu 225 230 Lys Asn Ser Gly Ile Phe Ser Glu 235 240 Phe Leu Lys Leu Ile Val Gly Asn 245 Gin Ala Asp Phe Arg Lys Tyr Phe 250 255 Asn Leu Asp Glu Lys Thr Ser Leu 260 Gin Phe Ser Lys Glu Ser Tyr Asp 265 270 Glu Asp Leu Glu Thr Leu Leu Gly 275 280 His Ile Gly Asp Asp Tyr Ser Asp 285 Val Phe Leu Lys Ala Lys Lys Leu 290 295 Tyr Asp Ala Ile Leu Leu Ser Gly 300 Ile Leu Thr Val Thr Asp Asn Gly 305 310 Thr Glu Ala Pro Leu Ser Ser Ala 315 320 Met Ile Met Arg Tyr Lys Glu His 325 Glu Glu Asp Leu Ala Leu Leu Lys 330 335 Ala Tyr Ile Arg Asn Ile Ser Leu 340 Glu Thr Tyr Asn Glu Val Phe Lys 345 350 Asp Asn Thr Lys Asn Gly Tyr Ala 355 360 Gly Tyr Ile Asp Gly Lys Thr Ser 365 Gin Glu Asp Phe Tyr Val Tyr Leu 370 375 Lys Arg Leu Leu Ala Gly Leu Glu 380 Gly Ala Asp Tyr Phe Leu Glu Lys 385 390 Ile Asp Arg Glu Asp Phe Leu Arg 395 400 Lys Gin Arg Thr Phe Asp Asn Gly 405 Ser Ile Pro Tyr Gin Ile Tyr Leu 410 415 Gin Glu Met Arg Ala Ile Leu Asp 420 Lys Gin Ala Lys Phe Tyr Pro Phe 425 430 Leu Ala Lys Asn Lys Glu Arg Ile 435 440 Glu Lys Ile Leu Thr Phe Arg Ile 445 Page 3562 of 3790 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 450 455 460 Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 465 470 475 480 Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Asn Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Arg 515 520 525 Phe Ile Ala Glu Gly Met Arg Asp Tyr Gin Phe Leu Asp Ser Lys Gin 530 535 540 Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Gly Lys Arg Lys Val Thr 545 550 555 560 Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Asp Gly Tyr Asp Gly 565 570 575 Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ser Ser Leu Ser Thr 580 585 590 Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 595 600 605 Ser Ser Asn Glu Thr Ile Ile Glu Glu Ile Ile His Thr Leu Thr Met 610 615 620 Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ser Lys Phe Asp Asn 625 630 635 640 Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 645 650 655 Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 660 665 670 Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Val Ser 675 680 685 Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ala Leu Ser Phe Lys Page 3564 of 3790 Page 3565 of 3790 Glu Asp 1385 1291 1392 PRT Streptococcus sanguinis 1291 Page 3566 of 3790 Met Glu Asn Lys Asn Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 15 10 15 Val Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys 20 25 30 Met Lys Val Phe Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu 35 40 45 Ile Gly Ala Leu Leu Phe Asp Glu Gly Ala Thr Ala Glu Asp Arg Arg 50 55 60 Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu 65 70 75 80 Arg Tyr Leu Gin Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser 85 90 95 Ser Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Lys Asp Lys 100 105 110 Arg Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu 115 120 125 Tyr His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala 130 135 140 Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 145 150 155 160 His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 165 170 175 Ile Lys Asn Asn Asp Ile Gin Lys Ile Phe Asn Glu Phe Ile Ser Ile 180 185 190 Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gin Asn Ala Gin 195 200 205 Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 210 215 220 Arg Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Ser Leu Phe Ser 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Page 3567 of 3790 Phe Asp Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Gly Phe Thr 275 280 285 Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Glu Arg Tyr Glu Ser His Gin Lys Asp Leu Ala Ala Leu 325 330 335 Lys Gin Phe Ile Lys Asn Asn Leu Pro Lys Arg Tyr Asn Glu Val Phe 340 345 350 Ser Asp Gin Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 355 360 365 Thr Gin Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 370 375 380 Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Leu Gin Glu Met Asn Ala Ile Leu Arg Arg Gin Gly Glu His Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 450 455 460 Trp Leu Thr Arg Asn Ser Asp Gin Ala Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Glu Phe Ile Asn Lys Met 485 490 495 Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 725 730 735 Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 Page 3569 of 3790 Page 3570 of 3790 Page 3571 of 3790 1292 1377 PRT Streptococcus sanguinis 1292 Met Lys Lys Pro Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 15 10 15 Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Met 20 25 30 Lys Val Leu Gly Asn Thr Asp Lys His Phe Ile Lys Lys Asn Leu Ile 35 40 45 Gly Ala Leu Leu Phe Asp Glu Gly Thr Thr Ala Glu Asp Arg Arg Leu 50 55 60 Page 3572 of 3790 Lys Arg Thr Ser Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Leu Arg 65 70 75 80 Tyr Leu Gin Glu Ile Phe Ser Glu Glu Ile Ser Lys Leu Asp Ser Ser 85 90 95 Phe Phe His Arg Leu Asp Asp Ser Phe Leu Val Pro Glu Asp Lys Arg 100 105 110 Gly Ser Lys Tyr Pro Ile Phe Ala Thr Leu Glu Glu Glu Lys Glu Tyr 115 120 125 His Lys Lys Phe Pro Thr Ile Tyr His Leu Arg Lys His Leu Ala Asp 130 135 140 Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp Ile 165 170 175 Lys Asn Asn Asp Ile Gin Lys Ile Phe Asn Glu Phe Ile Ser Ile Tyr 180 185 190 Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gin Asn Ala Gin Val 195 200 205 Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu Arg 210 215 220 Val Leu Lys Leu Phe Ser Asp Glu Lys Ser Thr Gly Leu Phe Ser Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His Phe 245 250 255 Asp Leu Glu Glu 260 Lys Ala Pro Leu Gin Phe 265 Ser Lys Asp Thr 270 Tyr Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Gly Phe Ala Asp 275 280 285 Leu Phe 290 Leu Val Ala Lys Lys 295 Leu Tyr Asp Ala Ile Leu Leu 300 Ser Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala Ser Page 3574 of 3790 Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 565 570 575 Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ala Ser Leu Ser Thr 580 585 590 Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Glu Phe Met Asp Asn 595 600 605 Pro Lys Asn Gly Glu Ile Leu Glu Asn Ile Ile His Thr Leu Thr Ile 610 615 620 Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Gin Tyr Asp Thr 625 630 635 640 Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 645 650 655 Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 660 665 670 Gin Thr Gly Lys Thr Ile Leu Glu Tyr Leu Ile Asp Asp Gly Asp Cys 675 680 685 Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 690 695 700 Glu Ile Ile Gin Lys Ala Gin Val Val Gly Lys Thr Asp Asp Val Lys 705 710 715 720 Gin Val Val Gin Glu Ile Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 725 730 735 Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly His 740 745 750 Asn Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr Thr 755 760 765 Ala Lys Gly Lys Lys Asn Ser Gin Gin Arg Tyr Lys Arg Ile Glu Asp 770 775 780 Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 785 790 795 800 Asn Pro Thr Asp Asn Ile Gin Leu Gin Asn Asp Arg Leu Phe Leu Tyr 805 810 815 Page 3575 of 3790 Val Arg Tyr Ala Asp Gly Thr Ile Lys Lys Arg Glu Asn Ile Glu 1055 1060 1065 Page 3576 of 3790 Val Glu Leu Leu Leu Gin Gin Ala Phe Asp Gin Ala Asp Lys Asp Page 3577 of 3790 1295 1300 1305 1370 1375 1293 1370 PRT Streptococcus sanguinis 1293 His Lys Gin Phe Pro Thr Ile Tyr His Leu Arg Lys Gin Leu Ala Asp Page 3579 of 3790 Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His Leu 405 410 415 Gin Glu Met Asn Ala Ile Leu Arg Arg Gin Gly Glu His Tyr Pro Phe 420 425 430 Leu Lys Glu Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Asp Asn Arg Asp Phe Ser Trp 450 455 460 Leu Thr Arg Asn Ser Asp Glu Pro Ile Arg Pro Trp Asn Phe Glu Glu 465 470 475 480 Val Val Asp Lys Ala Arg Ser Ala Glu Asp Phe Ile His Arg Met Thr 485 490 495 Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val Lys 515 520 525 Phe Ile Ala Glu Gly Leu Arg Asp Tyr Gin Phe Leu Asp Ser Gly Gin 530 535 540 Lys Lys Gin Ile Val Asn Gin Leu Phe Lys Glu Lys Arg Lys Val Thr 545 550 555 560 Glu Lys Asp Ile Ile His Tyr Leu His Asn Val Asp Gly Tyr Asp Gly 565 570 575 Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ala Asn Leu Ser Thr 580 585 590 Tyr His Asp Leu Leu Lys Ile Thr Lys Asp Lys Glu Phe Met Asp Asp 595 600 605 Pro Lys Asn Glu Glu Ile Leu Glu Asn Ile Val His Thr Leu Thr Ile 610 615 620 Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Gin Tyr Asp Thr 625 630 635 640 Page 3580 of 3790 Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg His Tyr Thr 645 650 655 Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Lys 660 665 670 Gin Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp Asp Lys Ile 675 680 685 Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu Ser Phe Lys 690 695 700 Glu Ile Ile Gin Lys Ala Gin Val Val Gly Lys Thr Asp Asp Val Lys 705 710 715 720 Gin Val Val Gin Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly Ile 725 730 735 Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly Tyr 740 745 750 Ala Leu Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr Thr 755 760 765 Ala Arg Gly Lys Lys Asn Ser Gin Gin Arg Tyr Lys Arg Ile Glu Asp 770 775 780 Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Asn Ile Leu Lys Glu 785 790 795 800 Asn Pro Thr Asp Asn Ile Gin Leu Lys Asn Asp Arg Leu Phe Leu Tyr 805 810 815 Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Lys Pro Leu Asp Ile 820 825 830 Asn Gin Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gin Ala Phe 835 840 845 Ile Lys Asp Asp Ser Ile Asp Asn Arg Val Leu Thr Ser Ser Lys Asp 850 855 860 Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Gin Lys 865 870 875 880 Arg Lys Ala Phe Trp Gin Gin Leu Leu Asp Ser Lys Leu Ile Ser Glu 885 890 895 Page 3581 of 3790 Lys Asp Ile Leu Trp Asp Thr Thr Lys Tyr Gly Gly Phe Asp Ser Page 3584 of 3790 Ile Ser Asp Glu Ser Lys Asn Ile Ala Asp Ile Phe Lys Ser Ser Glu 210 215 220 Asn Arg Gin Glu Lys Val Lys Lys Ile Leu Pro Tyr Phe Gin Gin Glu 225 230 235 240 Leu Leu Lys Lys Asp Lys Ser Ile Phe Lys Gin Leu Leu Gin Leu Leu 245 250 255 Phe Gly Leu Lys Thr Lys Phe Lys Asp Cys Phe Glu Leu Glu Glu Glu 260 265 270 Pro Asp Leu Asn Phe Ser Lys Glu Asn Tyr Asp Glu Asn Leu Glu Asn 275 280 285 Phe Leu Gly Ser Leu Glu Glu Asp Phe Ser Asp Val Phe Ala Lys Leu 290 295 300 Lys Val Leu Arg Asp Thr Ile Leu Leu Ser Gly Met Leu Thr Tyr Thr 305 310 315 320 Gly Ala Thr His Ala Arg Phe Ser Ala Thr Met Val Glu Arg Tyr Glu 325 330 335 Glu His Arg Lys Asp Leu Gin Arg Phe Lys Phe Phe Ile Lys Gin Asn 340 345 350 Leu Ser Glu Gin Asp Tyr Leu Asp Ile Phe Gly Arg Lys Thr Gin Asn 355 360 365 Gly Phe Asp Val Asp Lys Glu Thr Lys Gly Tyr Val Gly Tyr Ile Thr 370 375 380 Asn Lys Met Val Leu Thr Asn Pro Gin Lys Gin Lys Thr Ile Gin Gin 385 390 395 400 Asn Phe Tyr Asp Tyr Ile Ser Gly Lys Ile Thr Gly Ile Glu Gly Ala 405 410 415 Glu Tyr Phe Leu Asn Lys Ile Ser Asp Gly Thr Phe Leu Arg Lys Leu 420 425 430 Arg Thr Ser Asp Asn Gly Ala Ile Pro Asn Gin Ile His Ala Tyr Glu 435 440 445 Leu Glu Lys Ile Ile Glu Arg Gin Gly Lys Asp Tyr Pro Phe Leu Leu 450 455 460 Page 3585 of 3790 Glu Asn Lys Asp Lys Leu Leu Ser Ile Leu Thr Phe Lys Ile Pro Tyr 465 470 475 480 Tyr Val Gly Pro Leu Ala Lys Gly Ser Asn Ser Arg Phe Ala Trp Ile 485 490 495 Lys Arg Ala Thr Ser Ser Asp Ile Leu Asp Asp Asn Asp Glu Asp Thr 500 505 510 Arg Asn Gly Lys Ile Arg Pro Trp Asn Tyr Gin Lys Leu Ile Asn Met 515 520 525 Asp Glu Thr Arg Asp Ala Phe Ile Thr Asn Leu Ile Gly Asn Asp Ile 530 535 540 Ile Leu Leu Asn Glu Lys Val Leu Pro Lys Arg Ser Leu Ile Tyr Glu 545 550 555 560 Glu Val Met Leu Gin Asn Glu Leu Thr Arg Val Lys Tyr Lys Asp Lys 565 570 575 Tyr Gly Lys Ala His Phe Phe Asp Ser Glu Leu Arg Gin Asn Ile Ile 580 585 590 Asn Gly Leu Phe Lys Asn Asn Ser Lys Arg Val Asn Ala Lys Ser Leu 595 600 605 Ile Lys Tyr Leu Ser Asp Asn His Lys Asp Leu Asn Ala Ile Glu Ile 610 615 620 Val Ser Gly Val Glu Lys Gly Lys Ser Phe Asn Ser Thr Leu Lys Thr 625 630 635 640 Tyr Asn Asp Leu Lys Thr Ile Phe Ser Glu Glu Leu Leu Asp Ser Glu 645 650 655 Ile Tyr Gin Lys Glu Leu Glu Glu Ile Ile Lys Val Ile Thr Val Phe 660 665 670 Asp Asp Lys Lys Ser Ile Lys Asn Tyr Leu Thr Lys Phe Phe Gly His 675 680 685 Leu Glu Ile Leu Asp Glu Glu Lys Ile Asn Gin Leu Ser Lys Leu Arg 690 695 700 Tyr Ser Gly Trp Gly Arg Tyr Ser Ala Lys Leu Leu Leu Asp Ile Arg 705 710 715 720 Page 3586 of 3790 Asp Glu Asp Thr Gly Phe Asn Leu Leu Gin Phe Leu Arg Asn Asp Glu 725 730 735 Glu Asn Arg Asn Leu Thr Lys Leu Ile Ser Asp Asn Thr Leu Ser Phe 740 745 750 Glu Pro Lys Ile Lys Asp Ile Gin Ser Lys Ser Thr Ile Glu Asp Asp 755 760 765 Ile Phe Asp Glu Ile Lys Lys Leu Ala Gly Ser Pro Ala Ile Lys Arg 770 775 780 Gly Ile Leu Asn Ser Ile Lys Ile Val Asp Glu Leu Val Gin Ile Ile 785 790 795 800 Gly Tyr Pro Pro His Asn Ile Val Ile Glu Met Ala Arg Glu Asn Met 805 810 815 Thr Thr Glu Glu Gly Gin Lys Lys Ala Lys Thr Arg Lys Thr Lys Leu 820 825 830 Glu Ser Ala Leu Lys Asn Ile Glu Asn Ser Leu Leu Glu Asn Gly Lys 835 840 845 Val Pro His Ser Asp Glu Gin Leu Gin Ser Glu Lys Leu Tyr Leu Tyr 850 855 860 Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Leu Asp Lys Thr Gly Ser 865 870 875 880 Pro Ala Pro Leu Tyr Leu Asp Gin Leu Asp Gin Tyr Glu Val Asp His 885 890 895 Ile Ile Pro Tyr Ser Phe Leu Pro Ile Asp Ser Ile Asp Asn Lys Val 900 905 910 Leu Thr His Arg Glu Asn Asn Gin Gin Lys Leu Asn Asn Ile Pro Asp 915 920 925 Lys Glu Thr Val Ala Asn Met Lys Pro Phe Trp Glu Lys Leu Tyr Asn 930 935 940 Ala Lys Leu Ile Ser Gin Thr Lys Tyr Gin Arg Leu Thr Thr Ser Glu 945 950 955 960 Arg Thr Pro Asp Gly Val Leu Thr Glu Ser Met Lys Ala Gly Phe Ile 965 975 Page 3587 of 3790 970 1295 317 PRT Page 3589 of 3790 Streptococcus sp. 1295 Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp Ser Lys Phe Asn 15 10 15 Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Lys Ala Lys Leu 20 25 30 Asp Lys Glu Lys Ser Glu Glu Thr Tyr Val Leu Gly Lys Ile Lys Asp 35 40 45 Ile Tyr Ser Gin Ala Gly Tyr Asp Ala Phe Ile Lys Ile Tyr Asn Lys 50 55 60 Asp Lys Ser Lys Phe Leu Met Tyr His Lys Asp Pro Gin Thr Phe Glu 65 70 75 80 Lys Val Ile Glu Glu Ile Leu Arg Thr Tyr Pro Ser Lys Glu Leu Asn 85 90 95 Asp Lys Asn Lys Glu Ile Pro Cys Asn Pro Phe Glu Lys Tyr Arg Gin 100 105 110 Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Ser Asn Gly Pro Glu 115 120 125 Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn His Ile Asp 130 135 140 Ile Thr Pro Glu Ser Ser Asp Asn Gin Val Val Leu Gin Ser Leu Lys 145 150 155 160 Pro Trp Arg Thr Asp Val Tyr Phe Asn His Gin Thr Lys Lys Tyr Glu 165 170 175 Leu Met Gly Leu Lys Tyr Ser Asp Leu Ser Phe Glu Lys Gly Ser Gly 180 185 190 Lys Tyr Ser Ile Ser Asn Gin Lys Tyr Asn Ser Ile Lys Arg Ile Glu 195 200 205 Gly Ile Asp Glu Gin Ser Glu Phe Lys Phe Thr Leu Tyr Lys Asn Asp 210 215 220 Leu Ile Leu Ile Lys Asp Ser Glu Asn Asn Glu Gin Lys Leu Phe Arg 225 230 235 240 Page 3590 of 3790 Page 3591 of 3790 Arg Lys His Leu Ala Asp Ala Asp Lys Asn Ser Pro Val Ala Asp Ile 145 150 155 160 Arg Glu Val Tyr Met Val Leu Ser His Ile Leu Lys Tyr Arg Gly His 165 170 175 Phe Leu Thr Leu Gly Lys Ile Asp Pro Asn Asn Ile Asn Met Gin Asn 180 185 190 Ser Trp Ile Asp Phe Ile Glu Ser Cys Gin Asp Ala Phe Asp Leu Glu 195 200 205 Ile Ser Asp Glu Ser Lys Thr Ile Ala Ala Ile Phe Lys Ser Ser Glu 210 215 220 Asn Arg Gin Glu Lys Val Lys Gin Ile Leu Ser Tyr Phe Gin Gin Glu 225 230 235 240 Leu Leu Lys Lys Asp Lys Ser Ile Phe Lys Gin Leu Leu Gin Leu Leu 245 250 255 Phe Gly Leu Lys Thr Lys Phe Lys Asp Cys Phe Glu Leu Glu Glu Glu 260 265 270 Pro Asp Leu Asn Phe Ser Lys Glu Asn Tyr Asp Glu Asn Leu Glu Asn 275 280 285 Leu Leu Gly Ala Leu Glu Glu Asp Phe Ser Asp Val Phe Ala Lys Leu 290 295 300 Lys Ile Leu Arg Asp Thr Ile Leu Leu Ser Ser Met Leu Thr Tyr Thr 305 310 315 320 Gly Ala Thr His Ala Arg Phe Ser Ala Thr Met Val Glu Arg Tyr Glu 325 330 335 Glu His Arg Lys Asp Leu Gin Arg Phe Lys Ser Phe Val Lys Gin Asn 340 345 350 Leu Ser Glu Gin Asp Tyr Leu Asp Ile Phe Gly Arg Lys Thr Pro Thr 355 360 365 Gly Phe Asp Val Asp Lys Glu Thr Lys Gly Tyr Val Gly Tyr Ile Ser 370 375 380 Asn Lys Met Val Leu Thr Asn Pro Gin Lys Gin Lys Thr Ile Gin Gin 385 390 395 400 Page 3592 of 3790 Asn Phe Tyr Asp Tyr Ile Ser Gly Lys Ile Thr Gly Ile Glu Gly Ala 405 410 415 Glu Cys Phe Leu Asn Lys Ile Ser Asp Gly Thr Phe Leu Arg Lys Leu 420 425 430 Arg Thr Thr Asp Asn Gly Ala Ile Pro Asn Gin Ile His Ala Tyr Glu 435 440 445 Leu Glu Lys Ile Ile Glu Arg Gin Gly Arg Asp Tyr Pro Phe Leu Leu 450 455 460 Glu Asn Lys Asp Lys Leu Leu Ser Ile Leu Thr Phe Lys Ile Pro Tyr 465 470 475 480 Tyr Val Gly Pro Leu Ala Lys Gly Asn Asn Ser Arg Phe Ala Trp Ile 485 490 495 Lys Arg Thr Thr Ser Gin Asp Val Leu Asp Asp Asn Asp Glu Asp Thr 500 505 510 Arg Asn Gly Lys Ile Arg Pro Trp Asn Tyr His Lys Leu Ile Asn Met 515 520 525 Asp Glu Thr Arg Asp Ala Phe Ile Ile Asn Leu Ile Gly Asn Asp Ile 530 535 540 Ile Leu Leu Asn Glu Lys Val Leu Pro Lys Arg Ser Leu Ile Tyr Glu 545 550 555 560 Glu Val Met Leu Gin Asn Glu Leu Thr Arg Val Lys Tyr Lys Asp Lys 565 570 575 Tyr Gly Lys Ile His Phe Phe Asn Ser Glu Leu Arg Gin Glu Ile Ile 580 585 590 Asn Asn Leu Phe Lys Thr Asn Ser Lys Arg Val Ser Ser Ala Met Leu 595 600 605 Leu Ser Tyr Leu Glu Asn Phe Thr Asn Leu Gin Ala Val Glu Ile Val 610 615 620 Ser Gly Ile Glu Lys Gly Lys Ser Leu Asn Ser Thr Leu Lys Thr Tyr 625 630 635 640 Asn Asp Leu Lys Thr Ile Phe Ser Glu Glu Leu Leu Asp Ser Glu Ile Thr Pro Leu Tyr Arg Asp Gin Leu Asp Gin Tyr Glu Val Asp His Ile 885 890 895 Page 3594 of 3790 Tyr Asn Gin Asn Pro Val Gly Lys Leu Asn Lys Gin Ile Ala Ala 1130 1135 1140 Page 3595 of 3790 Page 3596 of 3790 1297 1371 PRT Streptococcus sp. 1297 Page 3597 of 3790 Ile Lys Asn Asn Asp Ile Gin Lys Ile Phe Asn Glu Phe Ile Ser Ile 180 185 190 Tyr Asn Asn Thr Phe Glu Gly Asn Ser Leu Ser Gly Gin Asn Val Gin 195 200 205 Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 210 215 220 Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asp Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Arg Asp Thr Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Asp Phe Ala 275 280 285 Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asn Pro Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Glu Arg Tyr Glu Asn His Gin Lys Asp Leu Ala Ser Leu 325 330 335 Lys Gin Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Asp Glu Val Phe 340 345 350 Ser Asp Gin Ser Glu Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 355 360 365 Thr Gin Glu Thr Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 370 375 380 Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Leu Gin Glu Met Asn Ala Ile Leu Arg Arg Gin Gly Glu His Tyr Pro 645 650 655 Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Ser Asp 660 665 670 Page 3599 of 3790 Lys Gin Thr Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Glu 675 680 685 Ile Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Gly Leu Ser Phe 690 695 700 Lys Glu Ile Ile Gin Lys Ala Gin Val Val Gly Lys Thr Asn Asp Val 705 710 715 720 Lys Gin Val Val Gin Glu Leu Pro Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met Gly 740 745 750 His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr 755 760 765 Thr Ala Arg Gly Lys Lys Asn Ser Gin Gin Arg Tyr Lys Arg Ile Glu 770 775 780 Asp Ser Leu Lys Ile Leu Ala Ser Gly Leu Asn Ser Lys Ile Leu Lys 785 790 795 800 Glu His Pro Thr Asp Asn Ile Gin Leu Gin Asn Asp Arg Leu Phe Leu 805 810 815 Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 820 825 830 Ile Asn Gin Leu Ser Ser Cys Asp Ile Asp His Ile Ile Pro Gin Ala 835 840 845 Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 850 855 860 Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Asp 865 870 875 880 Lys Met Lys Val Phe Trp Gin Gin Leu Leu Asp Ser Lys Leu Ile Ser 885 890 895 Tyr Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asn 900 905 910 Glu Leu Asp Lys Val Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg 915 920 925 Page 3600 of 3790 Page 3601 of 3790 Gly Glu Asp 1370 1298 93 PRT Streptococcus sp. Page 3602 of 3790 Asn Gin Gin Leu Thr Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Ile 100 105 110 Val Lys Arg Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Glu Asp Gly 115 120 125 Page 3603 of 3790 Gly Thr Val Ser Ser Asp Tyr Gly Lys Ala Val Glu Glu Asn Arg Lys 130 135 140 Leu Leu Ala Glu Gin Thr Pro Gly Gin Ile Gin Leu Glu Arg Phe Glu 145 150 155 160 Lys Tyr Gly Gin Val Arg Gly Asp Phe Thr Val Val Glu Asn Gly Glu 165 170 175 Lys Arg Arg Leu Ile Asn Val Phe Ser Thr Ser Ala Tyr Arg Lys Glu 180 185 190 Ala Glu Arg Ile Leu Arg Lys Gin Gin Glu Phe Asn Ser Lys Ile Thr 195 200 205 Asp Glu Phe Ile Glu Asp Cys Leu Lys Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Glu Tyr Arg Ala Ser Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Lys Val Ile 290 295 300 Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 305 310 315 320 Lys Tyr Ile Ala Lys Met Ile Asp Ala Ser Val Asp Gin Ile Arg Gly 325 330 335 Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Ile His Thr Phe Glu Ala 340 345 350 Tyr Arg Lys Met Gin Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 355 360 365 Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu Page 3605 of 3790 Gly Gin Arg Thr Pro Phe Gin Ala Leu Asp Ser Met Asp Asp Ala Trp 625 630 635 640 Ser Tyr Arg Glu Phe Lys Ser Tyr Val Lys Glu Ser Lys Leu Leu Gly 645 650 655 Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys Ile 660 665 670 Glu Val Lys Gin Lys Phe Ile Glu Arg Asn Leu Ile Asp Thr Arg Tyr 675 680 685 Ser Ser Arg Val Val Leu Asn Ala Leu Gin Asp Phe Tyr Lys Ala His 690 695 700 Lys Phe Asp Thr Thr Ile Ser Val Val Arg Gly Gin Phe Thr Ser Gin 705 710 715 720 Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 725 730 735 His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg Leu 740 745 750 Trp Lys Lys Gin Asn Asn Pro Leu Ile Ala Tyr Lys Glu Gly Gin Phe 755 760 765 Val Asp Ser Glu Thr Gly Glu Ile Ile Ser Leu Ser Asp Asp Glu Tyr 770 775 780 Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 785 790 795 800 Ser Ser Lys Thr Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp 805 810 815 Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 820 825 830 Lys Ala Lys Leu Asp Lys Glu Lys Ser Glu Glu Thr Tyr Val Leu Gly 835 840 845 Lys Ile Lys Asp Ile Tyr Ser Gin Ala Gly Tyr Asp Ala Phe Ile Lys 850 855 860 Ile Tyr Asn Lys Asp Lys Ser Lys Phe Leu Met Tyr His Lys Asp Pro 865 870 875 880 Page 3606 of 3790 Gly Asp Glu Pro Lys Leu Lys Phe 1115 1120 Page 3607 of 3790 1300 1026 PRT Streptococcus sp. Page 3608 of 3790 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Phe Arg Thr Asp Gly Thr Thr Leu Asp Asn Ile Phe Gly Val Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asn Glu Tyr Arg Ala Ser Lys Ser Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Lys Val Ile 290 295 300 Val Glu Tyr Ala Lys Glu Ala Lys Thr Leu Gly Ala Ser Thr Leu Leu 305 310 315 320 Lys Tyr Ile Val Lys Met Ile Asp Ala Ser Val Asp Gin Ile Ser Gly 325 330 335 Tyr Arg Val Asp Val Asn Asn Lys Pro Glu Met His Thr Phe Glu Val 340 345 350 Tyr Arg Lys Met Gin Ser Leu Glu Thr Ile Ser Val Gly Glu Leu Ser 355 360 365 Arg Asn Val Leu Asp Glu Leu Ala His Ile Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Glu Glu Ala Ile Asn Ser Lys Leu Met Gly Val Phe 385 390 395 400 Ser Gin Asp Gin Val Leu Glu Leu Val Gin Phe Arg Lys Asn Asn Ser 405 410 415 Ser Leu Phe Ser Lys Gly Trp His Asn Phe Ser Leu Lys Leu Met Met 420 425 430 Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr Ile 435 440 445 Leu Thr Arg Leu Gly Lys Gin Lys Ser Lys Glu Thr Ser Lys Arg Thr 450 455 460 Lys Tyr Ile Asp Glu Lys Glu Leu Thr Glu Glu Ile Tyr Asn Pro Val Page 3610 of 3790 Leu Arg Arg Lys Trp Gly Leu Glu Lys Ser Arg Glu Thr Tyr His His 725 730 735 His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg Leu 740 745 750 Trp Lys Lys Gin Asn Asn Pro Leu Ile Thr Tyr Lys Glu Gly Gin Phe 755 760 765 Ile Asp Ser Gin Thr Gly Glu Ile Ile Ser Leu Thr Asp Asp Glu Tyr 770 775 780 Lys Glu Leu Val Phe Lys Ala Pro Tyr Asp His Phe Val Asp Thr Leu 785 790 795 800 His Ser Lys Thr Phe Glu Asp Gly Ile Leu Phe Ser Tyr Gin Val Asp 805 810 815 Ser Lys Tyr Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 820 825 830 Lys Ala Lys Leu Asp Lys Asp Lys Ser Glu Glu Thr Tyr Val Leu Gly 835 840 845 Lys Ile Lys Asp Ile Tyr Ser Gin Ala Gly Tyr Asp Ala Phe Ile Lys 850 855 860 Ile Tyr Asn Lys Asp Lys Arg Lys Phe Leu Met Tyr His Lys Asp Pro 865 870 875 880 Gin Thr Phe Glu Lys Val Ile Glu Glu Ile Leu Arg Thr Tyr Pro Ser 885 890 895 Lys Glu Arg Asn Asp Lys Asn Lys Glu Val Pro Cys Asn Pro Phe Glu 900 905 910 Lys Tyr Arg Gin Glu Asn Gly Pro Ile Arg Lys Tyr Ser Lys Lys Gly 915 920 925 Asn Gly Pro Glu Ile Lys Cys Leu Lys Tyr Tyr Asp Asn Lys Leu Gly 930 935 940 Asn Tyr Ile Asp Ile Ser Pro Asp Gly Ser Asp Asn Gin Val Val Leu 945 950 955 960 Gin Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn His Gin Thr 965 970 975 Page 3611 of 3790 Lys Lys Tyr Glu Leu Met Gly Leu Lys Tyr Ser Asp Leu Ser Phe Glu 980 985 990 Lys Gly Ser Gly Lys Tyr Ser Ile Ser Asn Glu Lys Tyr Asn Ser Ile 995 1000 1005 Lys Arg Ile Glu Gly Val Asn Glu Gin Ser Glu Phe Lys Phe Thr 1010 1015 1020 Leu Tyr Lys 1025 1301 1377 PRT Streptococcus sp. Page 3612 of 3790 His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ala Phe Asp 165 170 175 Ile Lys Asn Asn Asp Ile Gin Lys Ile Phe Asn Glu Phe Ile Ser Ile 180 185 190 Tyr Asp Asn Thr Phe Glu Gly Ser Ser Leu Ser Gly Gin Asn Ala Gin 195 200 205 Val Glu Thr Ile Phe Thr Asp Lys Ile Ser Lys Ser Ala Lys Arg Glu 210 215 220 Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asp Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Glu Gin Ile Gly Asp Asp Phe Ala 275 280 285 Asp Leu Phe Val Ala Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Glu Arg Tyr Glu Asn His Gin Lys Asp Leu Ala Val Leu 325 330 335 Lys Gin Phe Ile Lys Thr Asn Leu Pro Glu Lys Tyr Val Glu Val Phe 340 345 350 Ser Asp Gin Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 355 360 365 Thr Gin Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 370 375 380 Asp Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Val Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Page 3613 of 3790 Leu Gin Glu Met Asn Thr Ile Leu Arg Arg Gin Gly Glu His Tyr Pro 420 425 430 Phe Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr His Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 450 455 460 Trp Leu Thr Arg Asn Ser Asp Gin Ala Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Asp Phe Ile Asn Lys Met 485 490 495 Thr Asn Tyr Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His 500 505 510 Ser Leu Leu Tyr Glu Thr Phe Ala Val Tyr Asn Glu Leu Thr Lys Val 515 520 525 Lys Phe Ile Ala Glu Gly Met Arg Asp Tyr Gin Phe Leu Asp Ser Gly 530 535 540 Gin Lys Lys Lys Ile Ile Asn Gin Leu Phe Lys Lys Lys Arg Lys Val 545 550 555 560 Thr Glu Asp Asp Ile Ile Asp Cys Leu Gin Lys Ile Asp Asn Tyr Asp 565 570 575 Gly Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ala Ser Leu Ser 580 585 590 Thr Tyr His Asp Ile Leu Lys Ile Ile Arg Asp Lys Glu Phe Met Asp 595 600 605 Asp Pro Lys Asn Gly Asp Ile Leu Glu Asn Val Ile His Thr Leu Thr 610 615 620 Ile Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ala Gin Tyr Asn 625 630 635 640 Ser Ile Phe Asp Glu Lys Val Ile Lys Ala Leu Ser Arg Lys His Tyr 645 650 655 Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asp Gly Ile Arg Asp Page 3615 of 3790 Page 3616 of 3790 1302 1371 Page 3617 of 3790 PRT Streptococcus sp. Page 3618 of 3790 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asp Leu Glu Glu Lys Ala Ser Leu Gin Phe Ser Lys Asp Thr Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Asp Phe Ala 275 280 285 Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Thr Asp Pro Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Glu Arg Tyr Glu Asn His Gin Glu Asp Leu Ala Ala Leu 325 330 335 Lys Gin Phe Ile Lys Asn Asn Leu Pro Glu Lys Tyr Ala Glu Val Phe 340 345 350 Ser Asp Gin Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 355 360 365 Thr Gin Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 370 375 380 Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu 385 390 395 400 Arg Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gin Ile His 405 410 415 Leu Gin Glu Met Asn Ala Ile Leu Arg Arg Gin Gly Glu His Tyr Pro 420 425 430 Leu Leu Lys Glu Asn Lys Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 435 440 445 Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Arg Asp Phe Ala 450 455 460 Trp Leu Thr Arg Asn Ser Asp Gin Ala Ile Arg Pro Trp Asn Phe Glu 465 470 475 480 Glu Ile Val Asp Lys Ala Ser Ser Ala Glu Ser Phe Ile Asn Lys Met Thr Gin Val Val Arg Glu Leu Ser Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Page 3620 of 3790 Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Ile Met Gly 740 745 750 Tyr Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn Gin Thr 755 760 765 Thr Ala Lys Gly Lys Lys Asn Ser Gin Gin Arg Tyr Lys Arg Ile Glu 770 775 780 Asp Ala Leu Lys Asn Leu Ala Pro Gly Leu Asp Ser Thr Ile Ser Lys 785 790 795 800 Glu Asn Pro Thr Asp Asn Ile Gin Leu Gin Asn Asp Arg Leu Phe Leu 805 810 815 Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly Glu Ala Leu Asp 820 825 830 Ile Asn Gin Leu Ser Ser Tyr Asp Ile Asp His Ile Ile Pro Gin Ala 835 840 845 Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser Ser Lys 850 855 860 Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val Val Lys 865 870 875 880 Lys Arg Lys Ala Phe Trp Gin Gin Leu Leu Asp Ser Lys Leu Ile Ser 885 890 895 Glu Arg Lys Phe Asn Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Asp 900 905 910 Glu Arg Asp Lys Val Gly Phe Ile Lys Arg Gin Leu Val Glu Thr Arg 915 920 925 Gin Ile Thr Lys His Val Ala Arg Ile Leu Asp Ala Arg Phe Asn Thr 930 935 940 Glu Val Ser Glu Lys Asn Gin Lys Ile Arg Ser Val Lys Ile Ile Thr 945 950 955 960 Leu Lys Ser Asn Leu Val Ser Asn Phe Arg Lys Glu Phe Lys Leu Tyr 965 970 975 Lys Val Arg Glu Ile Asn Asp Tyr His His Ala His Asp Ala Tyr Leu 980 985 990 Page 3621 of 3790 Asn Ala Val Val Ala Lys Ala Ile Leu Lys Lys Tyr Pro Lys Leu Glu 995 1000 1005 Page 3622 of 3790 Gly Glu Asp 1370 1303 1139 PRT Streptococcus sp. Page 3623 of 3790 Arg Leu Asn His Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 65 70 75 80 Lys Val Ser Ile Asn Leu Asn Pro Tyr Gin Leu Arg Val Lys Gly Leu 85 90 95 Thr Ala Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 100 105 110 Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 115 120 125 Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser Lys 130 135 140 Gin Leu Glu Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Tyr Gin 145 150 155 160 Lys Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly Arg 165 170 175 Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr His Ala Glu 180 185 190 Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Pro Gin Ile Thr 195 200 205 Asp Glu Phe Ile Asn Ser Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Lys 225 230 235 240 Tyr Thr Thr Lys Lys Asp Ala Gin Gly Gin Tyr Ile Thr Leu Asn Asn 245 250 255 Ile Phe Gly Ile Leu Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Tyr 260 265 270 Arg Ala Ala Lys Ala Ser Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn 275 280 285 Asp Leu Asn Asn Leu Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu 290 295 300 Glu Gin Lys Tyr Gin Ile Ile Thr Tyr Val Lys Asn Glu Lys Ala Met Page 3625 of 3790 Val Phe His Gly His Lys Gin Leu Ala Thr Lys Ile Arg Leu Trp His 565 570 575 Gin Gin Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 580 585 590 Asp Leu Ile Asn Asn Pro Asn Gin Phe Glu Ile Asp His Ile Leu Pro 595 600 605 Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 610 615 620 Ala Thr Ala Asn Gin Glu Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu 625 630 635 640 Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 645 650 655 Arg Glu Ser Lys Ala Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 660 665 670 Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 675 680 685 Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 690 695 700 Gin Glu His Phe Arg Thr His Lys Ile Asp Thr Lys Val Ser Val Val 705 710 715 720 Arg Gly Gin Phe Thr Ser Gin Leu Arg Arg His Trp Gly Ile Glu Lys 725 730 735 Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 740 745 750 Ala Ser Ser Gin Leu Asn Leu Trp Lys Lys Gin Lys Asn Thr Leu Val 755 760 765 Ser Tyr Ser Glu Asp Gin Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 770 775 780 Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gin His 785 790 795 800 Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 805 810 815 Page 3626 of 3790 Ile Phe Arg Phe Trp Ser Arg Thr Gly Lys Asp Asn Pro Lys Ser 1055 1060 1065 Page 3627 of 3790 1304 1375 PRT Streptococcus sp. Page 3628 of 3790 Asp Ser Lys Glu Lys Thr Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 145 150 155 160 His Met Ile Lys Tyr Arg Gly His Phe Leu Tyr Glu Glu Ser Phe Asp 165 170 175 Ile Lys Asn Asn Asp Ile Gin Lys Ile Phe Ser Glu Phe Ile Ser Ile 180 185 190 Tyr Asp Asn Thr Phe Glu Gly Lys Ser Leu Ser Gly Gin Asn Ala Gin 195 200 205 Val Glu Ala Ile Phe Thr Asp Lys Ile Ser Lys Ser Thr Lys Arg Glu 210 215 220 Arg Val Leu Lys Leu Phe Pro Asp Glu Lys Ser Thr Gly Leu Phe Ser 225 230 235 240 Glu Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Lys Lys His 245 250 255 Phe Asp Leu Glu Glu Lys Ala Pro Leu Gin Phe Ser Lys Asp Thr Tyr 260 265 270 Asp Glu Asp Leu Glu Asn Leu Leu Gly Gin Ile Gly Asp Asp Phe Ala 275 280 285 Asp Leu Phe Leu Val Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser 290 295 300 Gly Ile Leu Thr Val Lys Asp Leu Ser Thr Lys Ala Pro Leu Ser Ala 305 310 315 320 Ser Met Ile Glu Arg Tyr Glu Asn His Gin Lys Asp Leu Ala Ala Leu 325 330 335 Lys Gin Phe Ile Gin Asn Asn Leu Gin Glu Lys Tyr Asp Glu Val Phe 340 345 350 Ser Asp Gin Ser Lys Asp Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr 355 360 365 Thr Gin Glu Ala Phe Tyr Lys Tyr Ile Lys Asn Leu Leu Ser Lys Phe 370 375 380 Glu Gly Ala Asp Tyr Phe Leu Asp Lys Ile Glu Arg Glu Asp Phe Leu Page 3630 of 3790 Tyr Asp Ser Leu Phe Asp Glu Lys Val Ile Lys Ala Leu Thr Arg Arg 645 650 655 His Tyr Thr Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile 660 665 670 Arg Asp Lys Lys Ser Gly Lys Thr Ile Leu Asp Tyr Leu Ile Asp Asp 675 680 685 Gly Glu Ile Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Gly Leu 690 695 700 Ser Phe Lys Glu Ile Ile Gin Lys Ala Gin Val Phe Gly Lys Thr Asn 705 710 715 720 Asp Val Lys Gin Val Val Gin Glu Leu Pro Gly Ser Pro Ala Ile Lys 725 730 735 Lys Gly Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val 740 745 750 Met Gly His Ala Pro Glu Ser Ile Val Ile Glu Met Ala Arg Glu Asn 755 760 765 Gin Thr Thr Ala Arg Gly Lys Lys Asn Ser Gin Gin Arg Tyr Lys Arg 770 775 780 Ile Glu Asp Ser Leu Lys Asn Leu Ala Ser Gly Leu Asp Ser Asn Ile 785 790 795 800 Leu Lys Glu Asn Pro Thr Asp Asn Ile Gin Leu Gin Asn Asp Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Arg Asp Met Tyr Thr Gly Lys Pro 820 825 830 Leu Glu Ile Asn Gin Leu Ser Asn Tyr Asp Ile Asp His Ile Ile Pro 835 840 845 Gin Ala Phe Ile Lys Asp Asp Ser Leu Asp Asn Arg Val Leu Thr Ser 850 855 860 Ser Lys Asp Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Leu Glu Val 865 870 875 880 Val Glu Lys Met Lys Ala Phe Trp Gin Gin Leu Leu Asp Ser Lys Leu 885 890 895 Page 3631 of 3790 Page 3632 of 3790 Leu Ser Lys Leu Gly Glu Asp Page 3633 of 3790 1370 1375 1305 206 PRT Streptococcus sp. 1306 Page 3634 of 3790 1122 PRT Streptococcus suis Tyr Tyr Val Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Page 3636 of 3790 Val Val Ala Lys Ser Ile Arg Gin Thr Ile Lys Ile Ile Asn Ala Ser 485 490 495 Ile Lys Lys Trp Asp Glu Phe Asp Gin Ile Val Ile Glu Met Pro Arg 500 505 510 Asp Arg Asn Glu Asp Glu Glu Lys Lys Arg Ile Ala Asp Gly Gin Lys 515 520 525 Ala Asn Ala Lys Glu Lys Ala Asp Ser Ile Leu Arg Ala Ala Glu Leu 530 535 540 Tyr Cys Ala Gly Lys Val Leu Pro Asp Tyr Val Tyr Asn Gly His Asn 545 550 555 560 Gin Leu Ala Thr Lys Ile Arg Leu Trp Tyr Gin Gin Gly Glu Arg Cys 565 570 575 Ile Tyr Thr Gly Gin Pro Ile Ser Ile His Asp Leu Ile His Asn Gin 580 585 590 Asn Gin Tyr Glu Ile Asp His Ile Leu Pro Leu Ser Leu Thr Phe Asp 595 600 605 Asp Ser Leu Ser Asn Lys Val Leu Val Leu Ala Thr Ala Asn Gin Glu 610 615 620 Lys Ala Gin Arg Thr Pro Tyr Asn Tyr Leu Lys Ser Ala Thr Ser Ala 625 630 635 640 Trp Ser Tyr Arg Glu Phe Lys Asp Tyr Val Thr Lys Arg Lys Gly Ile 645 650 655 Gly Lys Lys Lys Cys Glu Tyr Leu Thr Phe Glu Glu Asp Ile Asn Gly 660 665 670 Phe Glu Val Arg Ser Lys Phe Ile Gin Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Lys Val Ile Leu Asn Ala Leu Gin Asp Tyr Phe Lys Ile 690 695 700 Ser Gly Ile Gin Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg His Lys Trp Gly Ile Glu Lys Thr Arg Glu Thr Tyr His 725 730 735 Page 3637 of 3790 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Arg 740 745 750 Leu Trp Lys Lys Gin Glu Ser Pro Leu Val Val Asp Tyr Gin Glu Gly 755 760 765 Arg Gin Val Asp Leu Glu Thr Gly Glu Ile Leu Glu Leu Thr Asp Glu 770 775 780 Gin Tyr Lys Glu Leu Val Tyr Gin Pro Pro Tyr Gin Gly Phe Val Asn 785 790 795 800 Thr Ile Ser Ser Ser Ala Phe Asp Asn Glu Ile Leu Phe Ser Tyr Gin 805 810 815 Val Asp Ser Lys Val Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala 820 825 830 Thr Arg Asn Ala Gin Leu Gly Lys Asp Lys Thr Glu Gly Ile Tyr Val 835 840 845 Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gin Ala Gly Tyr Glu Ala Phe 850 855 860 Leu Lys Arg Tyr Thr Lys Asp Lys Thr Ser Phe Leu Met Tyr His Lys 865 870 875 880 Asp Leu Asp Thr Trp Glu Lys Val Ile Glu Ile Ile Leu Arg Asp Tyr 885 890 895 Arg Glu Tyr Asp Glu Lys Gly Lys Glu Ile Gly Asn Pro Phe Glu Arg 900 905 910 Tyr Arg Arg Glu Asn Gly Tyr Val Lys Lys Tyr Ser Arg Lys Gly Asn 915 920 925 Gly Thr Ala Ile Lys Ser Leu Lys Tyr Tyr Asp Asn Lys Leu Gly Asn 930 935 940 His Ile Asp Ile Thr Pro Glu Asn Ser Arg Asn Ala Val Val Leu Gin 945 950 955 960 Ser Leu Lys Pro Trp Arg Thr Asp Val Tyr Phe Asn Lys Glu Thr Gly 965 970 975 Lys Tyr Glu Phe Leu Gly Ile Lys Tyr Ser Asp Leu Ser Phe Glu Lys 980 985 990 Page 3638 of 3790 Gly Thr Gly Glu Tyr Gly Ile Ser Gin Glu Lys Tyr Asp Ser Ile Lys 995 1000 1005 1307 1381 PRT Streptococcus suis Page 3639 of 3790 Leu Tyr Leu Gin Glu Ile Phe Ala Glu Glu Ile Asn Lys Ile Asp Asp 85 90 95 Ser Phe Phe Gin Arg Leu Asp Asp Ser Phe Leu Ile Val Glu Asp Lys 100 105 110 Gin Gly Ser Lys His Pro Ile Phe Gly Thr Leu Gin Glu Glu Lys Glu 115 120 125 Tyr His Lys Gin Phe Pro Thr Ile Tyr His Leu Arg Lys Gin Leu Ala 130 135 140 Asp Ser Ser Gin Lys Ala Asp Ile Arg Leu Ile Tyr Leu Ala Leu Ala 145 150 155 160 His Ile Ile Lys Tyr Arg Gly His Phe Leu Phe Glu Gly Asp Leu Lys 165 170 175 Ser Glu Asn Lys Asp Val Gin His Leu Phe Asn Asp Phe Val Glu Met 180 185 190 Phe Asp Lys Thr Val Glu Gly Ser Tyr Leu Ser Glu Asn Leu Pro Asn 195 200 205 Val Ala Asp Val Leu Val Glu Lys Val Ser Lys Ser Arg Arg Leu Glu 210 215 220 Asn Ile Leu His Tyr Phe Pro Asn Glu Lys Lys Asn Gly Leu Phe Gly 225 230 235 240 Asn Phe Leu Ala Leu Ala Leu Gly Leu Gin Pro Asn Phe Lys Thr Asn 245 250 255 Phe Glu Leu Ala Glu Asp Ala Lys Ile Gin Phe Ser Lys Glu Thr Tyr 260 265 270 Glu Glu Asp Leu Glu Glu Leu Leu Gly Lys Ile Gly Asp Asp Tyr Ala 275 280 285 Asp Leu Phe Ile Ala Thr Lys Ser Leu Tyr Asp Gly Ile Leu Leu Ala 290 295 300 Gly Ile Leu Ser Thr Thr Asp Ser Thr Thr Lys Ala Pro Leu Ser Ser 305 310 315 320 Ser Met Val Asn Arg Tyr Glu Glu His Gin Lys Asp Leu Ala Leu Leu Page 3641 of 3790 Gly Val Glu Leu Lys Gly Leu Glu Glu Gin Phe Asn Ala Ser Leu Pro 580 585 590 Thr Tyr His Asp Leu Leu Lys Ile Leu Arg Asp Lys Ala Phe Ile Asp 595 600 605 Ala Glu Glu Asn Gin Glu Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 610 615 620 Leu Phe Glu Asp Arg Glu Met Ile Arg Lys Arg Leu Glu Lys Tyr Lys 625 630 635 640 Asp Ile Leu Thr Glu Glu Gin Arg Lys Lys Leu Glu Arg Arg His Tyr 645 650 655 Thr Gly Trp Gly Arg Leu Ser Ala Lys Leu Ile Asn Gly Ile Leu Asp 660 665 670 Lys Val Thr Arg Lys Thr Ile Leu Gly Tyr Leu Ile Asp Asp Gly Thr 675 680 685 Ser Asn Arg Asn Phe Met Gin Leu Ile Asn Asp Asp Thr Leu Ser Phe 690 695 700 Val Asp Glu Ile Arg Leu Ala Gin Gly Ser Gly Glu Ala Glu Asp Tyr 705 710 715 720 Arg Ala Glu Val Gin Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 725 730 735 Ile Leu Gin Ser Leu Lys Ile Val Asp Glu Leu Ile Glu Val Met Gly 740 745 750 Tyr Glu Pro Glu His Ile Val Val Glu Met Ala Arg Glu Asn Gin Phe 755 760 765 Thr Asn Gin Gly Arg Arg Asn Ser Gin Gin Arg Ile Asn Arg Leu Glu 770 775 780 Asn Ala Leu Lys Asp Phe Gly Ser Lys Ile Leu Glu Glu Gin Lys Pro 785 790 795 800 Tyr Gly Val Ser Lys Val Asn Asn Ile His Leu Gin Ser Asp Arg Leu 805 810 815 Phe Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Asp Glu Glu 820 825 830 Page 3642 of 3790 Glu Thr Gly Glu Ile Val Trp Asp Lys Lys Ser Asp Phe Arg Thr 1070 1075 1080 Page 3643 of 3790 Arg Lys Asp Thr Asp Asn Leu Glu Glu Leu Cys Asn Ser Phe Ile 1308 39 PRT Streptococcus thermophilus 1308 Gly Arg Cys Ile Lys Gly Leu Gly Lys Ser Asn Ile Ser Ile Tyr Lys 15 10 15 Val Arg Thr Asp Val Leu Gly Asn Gin His Ile Ile Lys Asn Glu Gly 20 25 30 Asp Lys Pro Lys Leu Asp Phe 35 1309 302 PRT Streptococcus thermophilus Page 3645 of 3790 Page 3646 of 3790 Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Val Asn Ala Ala 485 490 495 Page 3648 of 3790 Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 500 505 510 Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Lys Ile Gin Lys 515 520 525 Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gin 530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 545 550 555 560 Gin Leu Ala Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 580 585 590 Asn Gin Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu Asp Ser Met Asp Asp Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 645 650 655 Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 660 665 670 Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gin Glu His Phe Arg Ala 690 695 700 His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Asn 740 745 750 Page 3649 of 3790 Page 3650 of 3790 1311 1121 PRT Streptococcus thermophilus 1311 Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 15 10 15 Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 20 25 30 Arg Ile Phe Pro Ala Ala Gin Ala Glu Asn Asn Leu Val Arg Arg Thr 35 40 45 Asn Arg Gin Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 50 55 60 Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 65 70 75 80 Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gin Leu Arg Val Lys Gly Leu 85 90 95 Page 3651 of 3790 Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 100 105 110 Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 115 120 125 Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser Lys 130 135 140 Gin Leu Glu Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Tyr Gin 145 150 155 160 Thr Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 165 170 175 Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 180 185 190 Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Pro Gin Ile Thr 195 200 205 Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gin Lys Asn Gin Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Glu 325 330 335 Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala Page 3653 of 3790 Asn Gin Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu Asp Ser Met Asp Asp Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 645 650 655 Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 660 665 670 Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gin Glu His Phe Arg Ala 690 695 700 His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ile Gin Leu Asn 740 745 750 Leu Trp Lys Lys Gin Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gin 755 760 765 Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 770 775 780 Glu Ser Val Phe Lys Ala Pro Tyr Gin His Phe Val Asp Thr Leu Lys 785 790 795 800 Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp Ser 805 810 815 Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gin 820 825 830 Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 835 840 845 Page 3654 of 3790 Gin Cys Lys Lys Gly Leu Gly Lys Ser Asn Ile Ser Ile Tyr Lys 1085 1090 1095 Page 3655 of 3790 Val Arg Thr Asp Val Leu Gly Asn Gin His Ile Ile Lys Asn Glu Page 3656 of 3790 Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Pro Gin Ile Thr 195 200 205 Asp Glu Phe Val Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Arg Thr Asn Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gin Lys Asn Gin Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 325 330 335 Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 340 345 350 Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gin Met Asp 355 360 365 Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Gin Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 385 390 395 400 Phe Ser Gin Lys Gin Val Asp Glu Leu Val Gin Phe Arg Lys Ala Asn 405 410 415 Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 420 425 430 Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr Page 3657 of 3790 435 440 445 Ile Leu Lys Arg Leu Gly Lys Gin Lys Thr Thr Ser Ser Ser Asn Lys 450 455 460 Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Ile Arg Gin Ala Ile Lys Ile Val Asn Ala Ala 485 490 495 Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 500 505 510 Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Lys Ile Gin Lys 515 520 525 Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gin 530 535 540 Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 545 550 555 560 Gin Leu Ala Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Arg Cys 565 570 575 Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Pro 580 585 590 Asn Gin Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 595 600 605 Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gin Glu 610 615 620 Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu Asp Ser Met Asp Asp Ala 625 630 635 640 Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 645 650 655 Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 660 665 670 Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 675 680 685 Page 3658 of 3790 Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gin Glu His Phe Arg Ala 690 695 700 His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr Ser 705 710 715 720 Gin Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 725 730 735 His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu Asn 740 745 750 Leu Trp Lys Lys Gin Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gin 755 760 765 Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 770 775 780 Glu Ser Val Phe Lys Ala Pro Tyr Gin His Phe Val Asp Thr Leu Lys 785 790 795 800 Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp Ser 805 810 815 Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gin 820 825 830 Ala Lys Val Gly Lys Asp Lys Lys Asp Glu Thr Tyr Val Leu Gly Lys 835 840 845 Ile Lys Asp Ile Tyr Thr Gin Asp Gly Tyr Asp Ala Phe Met Lys Ile 850 855 860 Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gin 865 870 875 880 Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 885 890 895 Glu Met Asn Glu Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 900 905 910 Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 915 920 925 Asp Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 930 935 940 Page 3659 of 3790 1115 1120 1313 1122 PRT Streptococcus thermophilus 1313 Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 15 10 15 Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 20 25 30 Page 3660 of 3790 Arg Ile Phe Pro Ala Ala Gin Ala Glu Asn Asn Val Glu Arg Arg Thr 35 40 45 Asn Arg Gin Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Arg Val 50 55 60 Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 65 70 75 80 Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gin Leu Arg Val Arg Gly Leu 85 90 95 Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 100 105 110 Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 115 120 125 Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser Lys 130 135 140 Gin Leu Glu Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Tyr Gin 145 150 155 160 Thr Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 165 170 175 Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 180 185 190 Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Ser Gin Ile Thr 195 200 205 Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 210 215 220 Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 225 230 235 240 Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 245 250 255 Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 260 265 270 Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 275 280 285 Page 3661 of 3790 Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gin Lys Asn Gin Ile 290 295 300 Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 305 310 315 320 Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 325 330 335 Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 340 345 350 Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gin Met Asp 355 360 365 Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 370 375 380 Arg Glu Gly Ile Gin Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 385 390 395 400 Phe Ser Gin Lys Gin Val Asp Glu Leu Val Gin Phe Arg Lys Ala Ser 405 410 415 Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 420 425 430 Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gin Met Thr 435 440 445 Ile Leu Thr Arg Leu Gly Lys Gin Lys Thr Thr Ser Ser Ser Asn Lys 450 455 460 Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 465 470 475 480 Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Val Asn Ala Ala 485 490 495 Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 500 505 510 Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Lys Ile Gin Lys 515 520 525 Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gin Page 3663 of 3790 Met Lys Glu Glu Gly Val Asp Ser Asp Ser Glu Phe Lys Phe Thr 1010 1015 1020 Leu Tyr Lys Asn Asp Leu Leu Leu Val Lys Asp Thr Glu Thr Lys 1025 1030 1035 Page 3664 of 3790 1314 1388 PRT Streptococcus thermophilus 1314 Page 3665 of 3790 His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 130 135 140 Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 165 170 175 Lys Asn Asn Asp Ile Gin Lys Asn Phe Gin Asp Phe Leu Asp Thr Tyr 180 185 190 Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gin Leu 195 200 205 Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 210 215 220 Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Arg Lys Cys Phe 245 250 255 Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 260 265 270 Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 275 280 285 Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 305 310 315 320 Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 325 330 335 Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 340 345 350 Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Gin Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 370 375 380 Page 3666 of 3790 Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Leu Asp Lys Gin Ala Lys Phe Tyr Pro Phe 420 425 430 Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 450 455 460 Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 465 470 475 480 Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 515 520 525 Phe Ile Ala Glu Ser Met Arg Asp Tyr Gin Phe Leu Asp Ser Lys Gin 530 535 540 Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 545 550 555 560 Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 565 570 575 Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ser Ser Leu Ser Thr 580 585 590 Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 595 600 605 Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 610 615 620 Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ser Lys Phe Glu Asn Page 3668 of 3790 Phe Asn Ala Asn Leu Ser Ser Lys Pro Lys Pro Asn Ser Asn Glu 1115 1120 1125 Page 3669 of 3790 Page 3670 of 3790 His Gin Ser Val Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ala 1370 1375 1380 Lys Leu Gly Glu Gly 1385 1315 1388 PRT Streptococcus thermophilus 1315 Page 3671 of 3790 Asn Ala Ile Phe Glu Ser Asp Leu 195 200 Ser Leu Glu Asn Ser Lys Gin Leu 205 Glu Glu Ile Val Lys Asp Lys Ile 210 215 Ser Lys Leu Glu Lys Lys Asp Arg 220 Ile Leu Lys Leu Phe Pro Gly Glu 225 230 Lys Asn Ser Gly Ile Phe Ser Glu 235 240 Phe Leu Lys Leu Ile Val Gly Asn 245 Gin Ala Asp Phe Arg Lys Cys Phe 250 255 Asn Leu Asp Glu Lys Ala Ser Leu 260 His Phe Ser Lys Glu Ser Tyr Asp 265 270 Glu Asp Leu Glu Thr Leu Leu Gly 275 280 Tyr Ile Gly Asp Asp Tyr Ser Asp 285 Val Phe Leu Lys Ala Lys Lys Leu 290 295 Tyr Asp Ala Ile Leu Leu Ser Gly 300 Phe Leu Thr Val Thr Asp Asn Glu 305 310 Thr Glu Ala Pro Leu Ser Ser Ala 315 320 Met Ile Lys Arg Tyr Asn Glu His 325 Lys Glu Asp Leu Ala Leu Leu Lys 330 335 Glu Tyr Ile Arg Asn Ile Ser Leu 340 Lys Thr Tyr Asn Glu Val Phe Lys 345 350 Asp Asp Thr Lys Asn Gly Tyr Ala 355 360 Gly Tyr Ile Asp Gly Lys Thr Asn 365 Gin Glu Asp Phe Tyr Val Tyr Leu 370 375 Lys Asn Leu Leu Ala Glu Phe Glu 380 Gly Ala Asp Tyr Phe Leu Glu Lys 385 390 Ile Asp Arg Glu Asp Phe Leu Arg 395 400 Lys Gin Arg Thr Phe Asp Asn Gly 405 Ser Ile Pro Tyr Gin Ile His Leu 410 415 Gin Glu Met Arg Ala Ile Leu Asp 420 Lys Gin Ala Lys Phe Tyr Pro Phe 425 430 Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile Page 3672 of 3790 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 450 455 460 Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 465 470 475 480 Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 515 520 525 Phe Ile Ala Glu Ser Met Arg Asp Tyr Gin Phe Leu Asp Ser Lys Gin 530 535 540 Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 545 550 555 560 Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 565 570 575 Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ser Ser Leu Ser Thr 580 585 590 Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 595 600 605 Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 610 615 620 Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ser Lys Phe Glu Asn 625 630 635 640 Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 645 650 655 Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 660 665 670 Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 675 680 685 Page 3673 of 3790 Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ala Leu Ser Phe Lys 690 695 700 Lys Lys Ile Gin Lys Ala Gin Ile Ile Gly Asp Glu Asp Lys Gly Asn 705 710 715 720 Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 740 745 750 Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Tyr Thr Asn Gin Gly Lys Ser Asn Ser Gin Gin Arg Leu Lys Arg 770 775 780 Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 785 790 795 800 Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gin Asn Asp 805 810 815 Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly 820 825 830 Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 835 840 845 Ile Pro Gin Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 850 855 860 Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 865 870 875 880 Glu Val Val Lys Lys Arg Lys Thr Phe Trp Tyr Gin Leu Leu Lys Ser 885 890 895 Lys Leu Ile Ser Gin Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 900 905 910 Gly Gly Leu Leu Pro Glu Asp Lys Ala Gly Phe Ile Gin Arg Gin Leu 915 920 925 Val Glu Thr Arg Gin Ile Thr Lys His Val Ala Arg Leu Leu Asp Glu 930 935 940 Page 3674 of 3790 Page 3675 of 3790 1385 1316 595 PRT Streptococcus thermophilus Page 3676 of 3790 1316 Met Val Gin 1 Phe Arg Lys Ala Asn Ser Ser Ile Phe Gly Lys Gly Trp 5 10 15 His Asn Phe Ser Val Lys Leu Met Met Glu Leu Ile Pro Glu Leu Tyr 20 25 30 Glu Thr Ser 35 Glu Glu Gin Met Thr Ile Leu Lys Arg Leu Gly Lys Gin 40 45 Lys Thr Thr 50 Ser Ser Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Leu 55 60 Leu Thr Glu 65 Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gin 70 75 80 Ala Ile Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp 85 90 95 Asn Ile Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys 100 105 110 Lys Ala Ile 115 Gin Lys Ile Gin Lys Ala Asn Lys Asp Glu Lys Asp Ala 120 125 Ala Met Leu 130 Lys Ala Ala Asn Gin Tyr Asn Gly Lys Ala Glu Leu Pro 135 140 His Ser Val 145 Phe His Gly His Lys Gin Leu Ala Thr Lys Ile Arg Leu 150 155 160 Trp His Gin Gin Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser 165 170 175 Ile His Asp Leu Ile Asn Asn Pro Asn Gin Phe Glu Val Asp His Ile 180 185 190 Leu Pro Leu 195 Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu 200 205 Val Tyr Ala 210 Thr Ala Asn Gin Glu Lys Gly Gin Arg Thr Pro Tyr Gin 215 220 Ala Leu Asp 225 Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala 230 235 240 Phe Val Arg Glu Ser Lys Thr Leu Ser Asn Lys Lys Lys Glu Tyr Leu Ile Leu Glu Asn Tyr Pro Asn Lys Glu Ile Asn Glu Lys Gly Lys Glu 485 490 495 Page 3678 of 3790 Page 3679 of 3790 Asp Ser Lys Tyr Pro Ile Phe Gly Asn Leu Val Glu Glu Lys Val Tyr 115 120 125 His Asp Glu Phe Pro Thr Ile Tyr His Leu Arg Lys Tyr Leu Ala Asp 130 135 140 Ser Thr Lys Lys Ala Asp Leu Arg Leu Val Tyr Leu Ala Leu Ala His 145 150 155 160 Met Ile Lys Tyr Arg Gly His Phe Leu Ile Glu Gly Glu Phe Asn Ser 165 170 175 Lys Asn Asn Asp Ile Gin Lys Asn Phe Gin Asp Phe Leu Asp Thr Tyr 180 185 190 Asn Ala Ile Phe Glu Ser Asp Leu Ser Leu Glu Asn Ser Lys Gin Leu 195 200 205 Glu Glu Ile Val Lys Asp Lys Ile Ser Lys Leu Glu Lys Lys Asp Arg 210 215 220 Ile Leu Lys Leu Phe Pro Gly Glu Lys Asn Ser Gly Ile Phe Ser Glu 225 230 235 240 Phe Leu Lys Leu Ile Val Gly Asn Gin Ala Asp Phe Arg Lys Cys Phe 245 250 255 Asn Leu Asp Glu Lys Ala Ser Leu His Phe Ser Lys Glu Ser Tyr Asp 260 265 270 Glu Asp Leu Glu Thr Leu Leu Gly Tyr Ile Gly Asp Asp Tyr Ser Asp 275 280 285 Val Phe Leu Lys Ala Lys Lys Leu Tyr Asp Ala Ile Leu Leu Ser Gly 290 295 300 Phe Leu Thr Val Thr Asp Asn Glu Thr Glu Ala Pro Leu Ser Ser Ala 305 310 315 320 Met Ile Lys Arg Tyr Asn Glu His Lys Glu Asp Leu Ala Leu Leu Lys 325 330 335 Glu Tyr Ile Arg Asn Ile Ser Leu Lys Thr Tyr Asn Glu Val Phe Lys 340 345 350 Asp Asp Thr Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Lys Thr Asn 355 360 365 Page 3680 of 3790 Gin Glu Asp Phe Tyr Val Tyr Leu Lys Asn Leu Leu Ala Glu Phe Glu 370 375 380 Gly Ala Asp Tyr Phe Leu Glu Lys Ile Asp Arg Glu Asp Phe Leu Arg 385 390 395 400 Lys Gin Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gin Ile His Leu 405 410 415 Gin Glu Met Arg Ala Ile Leu Asp Lys Gin Ala Lys Phe Tyr Pro Phe 420 425 430 Leu Ala Lys Asn Lys Glu Arg Ile Glu Lys Ile Leu Thr Phe Arg Ile 435 440 445 Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Asp Phe Ala Trp 450 455 460 Ser Ile Arg Lys Arg Asn Glu Lys Ile Thr Pro Trp Asn Phe Glu Asp 465 470 475 480 Val Ile Asp Lys Glu Ser Ser Ala Glu Ala Phe Ile Asn Arg Met Thr 485 490 495 Ser Phe Asp Leu Tyr Leu Pro Glu Glu Lys Val Leu Pro Lys His Ser 500 505 510 Leu Leu Tyr Glu Thr Phe Asn Val Tyr Asn Glu Leu Thr Lys Val Arg 515 520 525 Phe Ile Ala Glu Ser Met Arg Asp Tyr Gin Phe Leu Asp Ser Lys Gin 530 535 540 Lys Lys Asp Ile Val Arg Leu Tyr Phe Lys Asp Lys Arg Lys Val Thr 545 550 555 560 Asp Lys Asp Ile Ile Glu Tyr Leu His Ala Ile Tyr Gly Tyr Asp Gly 565 570 575 Ile Glu Leu Lys Gly Ile Glu Lys Gin Phe Asn Ser Ser Leu Ser Thr 580 585 590 Tyr His Asp Leu Leu Asn Ile Ile Asn Asp Lys Glu Phe Leu Asp Asp 595 600 605 Ser Ser Asn Glu Ala Ile Ile Glu Glu Ile Ile His Thr Leu Thr Ile 610 615 620 Page 3681 of 3790 Phe Glu Asp Arg Glu Met Ile Lys Gin Arg Leu Ser Lys Phe Glu Asn 625 630 635 640 Ile Phe Asp Lys Ser Val Leu Lys Lys Leu Ser Arg Arg His Tyr Thr 645 650 655 Gly Trp Gly Lys Leu Ser Ala Lys Leu Ile Asn Gly Ile Arg Asp Glu 660 665 670 Lys Ser Gly Asn Thr Ile Leu Asp Tyr Leu Ile Asp Asp Gly Ile Ser 675 680 685 Asn Arg Asn Phe Met Gin Leu Ile His Asp Asp Ala Leu Ser Phe Lys 690 695 700 Lys Lys Ile Gin Lys Ala Gin Ile Ile Gly Asp Glu Asp Lys Gly Asn 705 710 715 720 Ile Lys Glu Val Val Lys Ser Leu Pro Gly Ser Pro Ala Ile Lys Lys 725 730 735 Gly Ile Leu Gin Ser Ile Lys Ile Val Asp Glu Leu Val Lys Val Met 740 745 750 Gly Gly Arg Lys Pro Glu Ser Ile Val Val Glu Met Ala Arg Glu Asn 755 760 765 Gin Tyr Thr Asn Gin Gly Lys Ser Asn Ser Gin Gin Arg Leu Lys Arg 770 775 780 Leu Glu Lys Ser Leu Lys Glu Leu Gly Ser Lys Ile Leu Lys Glu Asn 785 790 795 800 Ile Pro Ala Lys Leu Ser Lys Ile Asp Asn Asn Ala Leu Gin Asn Asp 805 810 815 Arg Leu Tyr Leu Tyr Tyr Leu Gin Asn Gly Lys Asp Met Tyr Thr Gly 820 825 830 Asp Asp Leu Asp Ile Asp Arg Leu Ser Asn Tyr Asp Ile Asp His Ile 835 840 845 Ile Pro Gin Ala Phe Leu Lys Asp Asn Ser Ile Asp Asn Lys Val Leu 850 855 860 Val Ser Ser Ala Ser Asn Arg Gly Lys Ser Asp Asp Phe Pro Ser Leu 880 865 870 Page 3682 of 3790 875 Glu Glu Gin Asn His Gly Leu Asp Arg Gly Lys Pro Lys Gly Leu 1100 1105 1110 Page 3683 of 3790 Page 3684 of 3790 Arg Asp Tyr Thr Pro Ser Ser Leu Leu Lys Asp Ala Thr Leu Ile 1355 1360 1365 His Gin Ser Val Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ala 1370 1375 1380 Lys Leu Gly Glu Gly 1385 Met Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp 20 25 30 Gly Asn Ser Ser Val Gly Asp Tyr Ala Gin Ile Val Lys Glu Asn Ser 35 40 45 Lys Gin Leu Glu Thr Lys Thr Pro Gly Gin Ile Gin Leu Glu Arg Tyr 50 55 60 Gin Lys Tyr Gly Gin Leu Arg Gly Asp Phe Thr Val Glu Glu Asp Gly 65 70 75 80 Lys Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ala 85 90 95 Glu Ala Leu Arg Ile Leu Gin Thr Gin Gin Glu Phe Asn Ser Gin Ile 100 105 110 Thr Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg 115 120 125 Lys Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly 130 135 140 Arg Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu 145 150 155 160 Ile Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala 165 170 175 Page 3685 of 3790 Ser Tyr Thr Ala Gin Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu 180 185 190 Thr Val Pro Thr Glu Thr Lys Lys Leu Ser Glu Glu Gin Lys Asn Gin 195 200 205 Ile Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu 210 215 220 Phe Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Ile Ala Asp Ile Lys 225 230 235 240 Gly Tyr Arg Ile Asp Lys Ser Asp Lys Ala Glu Ile His Thr Phe Glu 245 250 255 Ala Tyr Arg Lys Met Lys Thr Leu Glu Thr Ile Asp Ile Glu Lys Met 260 265 270 Ser Arg Glu Glu Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr 275 280 285 Glu Arg Glu Gly Ile Gin Glu Ala Leu Glu His Glu Phe Val Asp Gly 290 295 300 Asn Phe Ser Gin Glu Gin Ile Asp Glu Leu Val Gin Phe Arg Lys Ala 305 310 315 320 Asn Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu 325 330 335 Met Met Glu Leu Ile Pro Glu Leu Tyr Ala Thr Ser Glu Glu Gin Met 340 345 350 Thr Ile Leu Thr Arg Leu Gly Lys Gin Lys Thr Thr Ser Ser Ser Asn 355 360 365 Lys Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn 370 375 380 Pro Val Val Ala Lys Ser Val Arg Gin Ala Ile Lys Ile Val Asn Ala 385 390 395 400 Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala 405 410 415 Arg Ala Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gin Lys Ile Gin 420 425 430 Page 3686 of 3790 Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn 435 440 445 Gin Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His 450 455 460 Lys Gin Leu Ala Thr Lys Ile Arg Leu Trp His Gin Gin Gly Glu Arg 465 470 475 480 Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn 485 490 495 Pro Asn Gin Phe Glu Ile Asp His Ile Leu Pro Leu Ser Ile Thr Phe 500 505 510 Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gin 515 520 525 Glu Lys Gly Gin Arg Thr Pro Tyr Gin Ala Leu Asp Ser Met Asp Asp 530 535 540 Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr 545 550 555 560 Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser 565 570 575 Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr 580 585 590 Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gin Glu His Phe Arg 595 600 605 Ala His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gin Phe Thr 610 615 620 Ser Gin Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr 625 630 635 640 His His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gin Leu 645 650 655 Asn Leu Trp Lys Lys Gin Lys Asn Thr Leu Val Asn Tyr Ser Glu Asn 660 665 670 Gin Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Page 3687 of 3790 675 680 685 Lys Glu Ser Val Phe Lys Ala Pro Tyr Gin His Phe Val Asp Thr Leu 690 695 700 Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gin Val Asp 705 710 715 720 Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg 725 730 735 Lys Ala Lys Leu Asp Lys Glu Lys Lys Glu Tyr Thr Tyr Thr Leu Gly 740 745 750 Lys Ile Lys Asp Ile Tyr Ala Leu Gly Thr Lys Thr Pro Ser Lys Thr 755 760 765 Gly Phe Tyr Lys Phe Leu Asp Leu Tyr Lys Lys Asn Lys Ser Gin Phe 770 775 780 Leu Met Tyr Gin Lys Asp Arg Lys Thr Trp Asp Glu Val Ile Glu Lys 785 790 795 800 Ile Leu Glu Gin Tyr Arg Pro Phe Lys Glu Lys Asp Lys Asn Gly Lys 805 810 815 Glu Val Asp Phe Asn Pro Phe Glu Lys Tyr Arg Ile Glu Asn Gly Pro 820 825 830 Ile Arg Lys Tyr Ser Arg Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu 835 840 845 Lys Tyr Tyr Asp Asn Leu Leu Gly Arg Phe Val Asp Ile Thr Pro Ser 850 855 860 Glu Ser Lys Asn Pro Val Ala Leu Leu Ser Leu Asn Pro Trp Arg Thr 865 870 875 880 Asp Val Tyr Tyr Asn Thr Glu Thr Arg Lys Tyr Glu Phe Leu Gly Leu 885 890 895 Lys Tyr Ala Asp Leu Cys Phe Glu Lys Gly Gly Ser Tyr Gly Ile Ser 900 905 910 Lys Val Lys Tyr Asn Lys Ile Arg Glu Lys Glu Gly Ile Gly Lys Asn 915 920 925 Page 3688 of 3790 Glu Asn Leu Ser Ile Phe Lys Val Arg Thr Asp Val Leu Gly Asn 1010 1015 1020 Gin His Ile Ile Lys Asn Glu Gly Asp Lys Pro Lys Leu Asp Phe Arg Page 3689 of 3790 1320 1084 PRT Subdoligranulum sp. Page 3690 of 3790 Tyr Leu Ser Ile Leu Leu Arg Gin Arg Ser Phe Asp Glu Gly Pro Gly 225 230 235 240 Gly Asn Ser Pro Tyr Gly Gly Asn Gin Val Glu Lys Met Val Gly Arg 245 250 255 Cys Thr Phe Glu Pro Asp Glu Pro Arg Ala Ala Lys Ala Ala Tyr Ser 260 265 270 Phe Glu Tyr Phe Ser Leu Leu Gin Lys Leu Asn His Ile Arg Leu Ala 275 280 285 Glu Asn Gly Glu Thr Arg Pro Leu Thr Gin Pro Gin Arg Gin Gin Leu 290 295 300 Leu Ser Leu Ala His Lys Thr Pro Asp Ile Ser Leu Ala Arg Ile Arg 305 310 315 320 Lys Glu Leu Ala Leu Pro Glu Thr Val Gin Phe Asn Gly Val Arg Cys 325 330 335 Arg Ala Asn Glu Thr Leu Glu Glu Ser Glu Lys Lys Glu Lys Phe Ala 340 345 350 Cys Leu Pro Ala Tyr His Lys Met Arg Lys Ala Leu Asp Gly Val Val 355 360 365 Lys Gly Arg Ile Ser Ser Leu Ser Ile Ser Gin Arg Asp Ala Ala Ala 370 375 380 Thr Ala Leu Ser Leu Tyr Lys Asn Glu Asp Thr Leu Arg Ala Lys Leu 385 390 395 400 Thr Glu Ala Gly Phe Gin Ala Pro Glu Ile Asp Ala Leu Ala Gly Leu 405 410 415 Thr Gly Phe Ser Lys Phe Gly His Leu Ser Leu Lys Ala Cys Arg Lys 420 425 430 Leu Ile Pro His Leu Glu Gin Gly Leu Thr Tyr Asp Gin Ala Cys Thr 435 440 445 Ala Ala Gly Tyr Asp Phe Lys Gly His Gly Ala Gly Glu Arg Ala Phe 450 455 460 Thr Leu Pro Ala Ala Ala Pro Glu Met Glu Gin Ile Thr Ser Pro Val 465 470 475 480 Page 3691 of 3790 Val Arg Arg Ala Val Ala Gin Thr Ile Lys Val Val Asn Gly Ile Ile 485 490 495 Arg Glu Met Asp Ala Ser Pro Ala Trp Val Arg Ile Glu Leu Ala Arg 500 505 510 Glu Leu Ser Lys Thr Phe Gly Glu Arg Gin Glu Met Asp Arg Ser Met 515 520 525 Arg Glu Asn Ala Ala Gin Asn Glu Arg Leu Met Gin Glu Leu Arg Asp 530 535 540 Thr Phe His Leu Leu Ser Pro Thr Gly Gin Asp Leu Val Lys Tyr Arg 545 550 555 560 Leu Trp Lys Glu Gin Asp Gly Val Cys Ala Tyr Ser Leu Arg Arg Leu 565 570 575 Asp Val Glu Arg Leu Phe Glu Pro Gly Tyr Val Asp Val Asp His Ile 580 585 590 Val Pro Tyr Ser Leu Ser Phe Asp Asp Arg Arg Ser Asn Lys Val Leu 595 600 605 Val Leu Ser Ser Glu Asn Arg Gin Lys Gly Asn Arg Leu Pro Leu Gin 610 615 620 Tyr Leu Gin Gly Lys Arg Arg Glu Asp Phe Ile Val Trp Thr Asn Ser 625 630 635 640 Ser Val His Asp Tyr Arg Lys Arg Gin Asn Leu Leu Arg Glu Lys Leu 645 650 655 Ser Gly Asp Glu Ala Glu Gly Phe Arg Gin Arg Asn Leu Gin Asp Thr 660 665 670 Gin His Met Ala Arg Phe Leu Tyr Asn Tyr Ile Ser Asp His Leu Ala 675 680 685 Phe Ala Gin Ser Glu Ala Leu Gly Lys Lys Arg Val Phe Ala Val Ser 690 695 700 Gly Ala Val Thr Ser His Leu Arg Lys Arg Trp Gly Leu Ser Lys Val 705 710 715 720 Arg Ala Asp Gly Asp Leu His His Ala Leu Asp Ala Ala Val Val Ala 725 730 735 Page 3692 of 3790 Cys Thr Thr Asp Gly Met Ile Arg Arg Ile Ser Gly Tyr Tyr Gly His 740 745 750 Ile Glu Gly Glu Tyr Leu Gin Asp Ala Asp Gly Ala Gly Ser Gin His 755 760 765 Ala Arg Thr Lys Glu Arg Phe Pro Ala Pro Trp Pro Arg Phe Arg Asp 770 775 780 Glu Leu Ile Val Arg Leu Ser Glu Gin Pro Ala Glu Pro Leu Leu Asp 785 790 795 800 Ile Asn Pro Glu Phe Tyr Cys Glu Tyr Gly Thr Glu His Ile Arg Pro 805 810 815 Val Phe Val Ser Arg Met Pro Arg Arg Lys Val Thr Gly Pro Gly His 820 825 830 Lys Glu Thr Ile Lys Gly Ala Ala Ala Ala Asp Glu Gly Leu Leu Thr 835 840 845 Val Arg Lys Ala Leu Thr Glu Leu Lys Leu Asp Lys Asp Gly Glu Ile 850 855 860 Lys Asp Tyr Tyr Met Pro Ser Ser Asp Thr Leu Leu Tyr Glu Ala Leu 865 870 875 880 Lys Ala Gin Leu Arg Arg Phe Gly Gly Asp Gly Lys Lys Ala Phe Ala 885 890 895 Glu Pro Phe Tyr Lys Pro Lys Ala Asp Gly Thr Pro Gly Pro Leu Val 900 905 910 Arg Lys Val Lys Thr Thr Glu Lys Ala Thr Leu Thr Val Pro Val His 915 920 925 Gly Gly Ala Ala Ser Asn Asp Thr Met Val Arg Val Asp Val Phe Leu 930 935 940 Val Pro Gly Asp Gly Tyr Tyr Trp Val Pro Val Tyr Thr Ala Asp Thr 945 950 955 960 Leu Lys Pro Glu Leu Pro Asn Arg Ala Val Val Gin Gly Lys Pro Tyr 965 970 975 Ser Glu Trp Lys Glu Met Arg Glu Glu Asp Phe Ile Phe Ser Leu Tyr 980 990 Page 3693 of 3790 985 Pro Asn Asp Leu Val Tyr Val Glu His Lys Ser Gly Leu Lys Phe Thr 995 1000 1005 Arg 1321 951 PRT Sutterella parvirubra 1321 Asp Glu Glu Met Arg Arg Thr Val Glu Ala Leu Ser Ser Leu Leu Lys Page 3695 of 3790 Leu Trp Leu Ser Ala Ala Glu Leu Thr Arg Arg Tyr Gly Asp Lys Trp 355 360 365 Arg Ile Trp Ser Gin Lys Phe Glu Arg Ala Asp Arg Ala Leu Ser Thr 370 375 380 Gly Leu Asp Glu Ile Leu Leu Tyr Thr Asp Arg Arg Ser Arg Met Phe 385 390 395 400 Asn Arg Asn Gin Asp Pro Ser Val Tyr Ala Asp Ser Tyr Val Leu Gin 405 410 415 Arg Val Leu Asp Arg Ser Ser Lys Leu Asp Arg Tyr Ala Leu Arg Ala 420 425 430 Leu Ala Ala Gly Tyr Arg Thr Gin Glu Leu His Glu Pro Leu Ala Thr 435 440 445 Leu Ser Asp Thr Leu Gly Thr Gin His Val Glu Thr Phe Leu Thr Phe 450 455 460 Ala Ala Glu Tyr Tyr Glu Glu Val Ala Ala Ala Lys Asn Gly Leu Trp 465 470 475 480 Leu Asp Gly Pro Ser Arg Leu Leu Glu Arg Ala Asp Ile His Pro Pro 485 490 495 Met Lys Lys Lys Val Leu Asp Leu Leu Leu Gly Asn Ile Leu Asp Ala 500 505 510 Thr Pro Glu Ile Gly Arg Ile Leu Arg Thr Val Leu Trp Asn Arg His 515 520 525 Val His Glu Lys Ser Arg Ser Thr Pro Ala Ser Leu Cys Arg Ser Ile 530 535 540 Glu Ala Ile Arg Lys Asp Phe Gly Gly Glu Phe Arg Met Arg Tyr Asp 545 550 555 560 Ala Leu Asp Ala Lys Ile Arg Ala Ala Glu Asp Gin Lys Lys Lys Phe 565 570 575 Lys Pro Thr Asn Ala Glu Glu Lys Asp Leu Phe Lys Ala Trp Asn Ala 580 585 590 Thr Lys Thr Met His Ala Phe Leu Arg Asp Val Leu Gin Leu Thr Pro 595 600 605 Page 3696 of 3790 Lys Gin Leu Glu Arg Thr Ala Ser Pro Tyr Val Phe Ala Gin Leu His 610 615 620 Thr Leu Ile Asp Thr Glu Arg Asp Gly Phe Thr Ser Thr Ser Leu Ala 625 630 635 640 Ala His Leu Glu Asn His Trp Arg Met Arg Ala Asn Ala Ala Gly Met 645 650 655 Ala Gin Cys Ser Arg Leu Pro Ala Asp Ala Val Arg Pro Phe Asp Gly 660 665 670 Val Leu Ser Lys Ala Leu Asp Arg Gin Ala Phe Glu Ala Ala Lys Leu 675 680 685 Ala Ala Gin His Leu Met Ser Arg Lys Glu Leu Thr Asp Thr Asp Ile 690 695 700 Arg Tyr Ser Ile Ile Ile Glu Ser Asn Arg Phe Ala Phe Ser Ala Ser 705 710 715 720 Thr Ala Glu Leu Lys Lys Asn Thr Leu Ala Lys Lys Asn Ala Glu Lys 725 730 735 Gly Leu Asn Phe Glu Leu Lys Arg Trp Gin Asp Lys Asp Ser Arg Ile 740 745 750 Arg Glu Ala Ser Arg Gly Ile Cys Ala Tyr Thr Gly Ala Lys Leu Gly 755 760 765 Asp Val Val Glu Tyr Asp His Ile Ile Pro Arg Ala Phe Thr Thr Ser 770 775 780 Ala Met Gly Ser Val Phe Asn Ser Glu Ala Asn Leu Ile Cys Val Ser 785 790 795 800 Arg Pro Gly Asn Gin Thr Lys Ala Asp Lys Arg Tyr Gly Leu Asn Lys 805 810 815 Leu His Lys Thr Tyr Leu Thr Ala Val Phe Gly Thr Ala Asp Val Thr 820 825 830 Thr Ile Ala Ala Ser Ile Glu Asp Ile Val Gly Lys Leu Ala Ser Ala 835 840 845 Asn Arg Leu Arg His Phe Glu Leu Leu Asn Glu Lys Glu Gin Asp Ala 850 855 860 Page 3697 of 3790 Val Arg His Ala Leu Phe Leu Asp Asp Glu Ser Asp Ala Arg Arg Ile 865 870 875 880 Val Leu Arg Glu Leu Ala Ala Gin Asn Lys Ser Arg Val Asn Gly Thr 885 890 895 Gin Ala Trp Phe Val Arg Ala Phe Met Thr Lys Leu Leu Glu Ile Thr 900 905 910 Lys Asp Trp Arg Glu Arg Thr Gly Asn Thr Leu Asp Ile Arg Ser Trp 915 920 925 Lys Thr Asp Ala Glu Val Ala Ser Arg Leu Arg Ser Ala Leu Asn Phe 930 935 940 His Ala Glu Ile Thr Leu Thr 945 950 1322 406 PRT Sutterella parvirubra 1322 Ser Asn Leu Phe Arg Glu Glu Val Pro Tyr Gly Asp His Phe Leu Pro 15 10 15 Ile Ile Gin Met Lys Asn Arg Ile Tyr Ile Gly Tyr Gin Leu Pro Lys 20 25 30 Ala Asp Gly Thr Gly Gly Asn Ala Val Ala Val Leu Gly Lys Asp Pro 35 40 45 Leu Glu Leu Leu Glu Thr Leu Lys Pro Phe Leu Asp Arg Glu Pro Gin 50 55 60 Ala Phe Ser Asp His Pro Val Thr Tyr Lys Met Ile Asn Glu Arg Ala 65 70 75 80 Tyr Glu Leu Leu Thr Lys Cys Ala Leu Thr Pro Asp Gin Thr Thr Glu 85 90 95 Leu Glu Arg Thr Gin Ala Glu Val Leu Arg Ser Leu Asn Tyr Gin Thr 100 105 110 Ser Arg Ala Ala Val Leu Gly Arg Leu Val Asp Asp Lys Asn Lys Phe 115 120 125 Page 3698 of 3790 Val Ala Lys Asp Ala Val Trp Lys Glu Lys Asp Phe Val Ile Ser Phe 130 135 140 Lys Leu Ser Pro Lys Lys Ser Ala Phe Lys Ala Ser Gly Gin Leu Glu 145 150 155 160 Leu Pro Ala Lys Ser Asp Trp Lys Ala Leu Val Asp Ser Pro Glu Leu 165 170 175 Ala Ile Asn Trp Gly Gin Pro Ala Asp Asp Thr Phe Ser Gin Arg Ile 180 185 190 Glu Arg Lys Val Arg Met Asn Ser Ser His Leu Glu His Thr Pro Lys 195 200 205 Lys Arg Val Val Ser Leu Pro Val Val Asp Lys Pro Ser Gly Gly Phe 210 215 220 Arg Ile Arg Arg His Asn Leu Asp Gly Ser Ala Val Phe Gin Val His 225 230 235 240 Thr Val Ala Asn Asn Lys Tyr Gly Gly Phe Ser Ala Asp Ser Ala Gly 245 250 255 Lys Val Asp Trp Ser Thr Pro Val Leu Cys Gly His Leu Gin His Ala 260 265 270 Asn Leu Val Pro Leu Asp Pro Glu Thr Ala Ser Ala Glu Gin Leu Val 275 280 285 Arg Met Ser Glu Trp Arg Val Val Glu Thr Thr Ser Asp Ile Arg Leu 290 295 300 Glu Val Cys Pro Gly Thr Ser Gly Arg Arg Tyr Val Arg Val Glu Leu 305 310 315 320 Pro Phe Thr Leu Leu Gin Glu Trp Leu Thr Ala Gly Lys Val Ala Asp 325 330 335 Val Pro Val Ser Pro Leu His Leu Pro Gly Ser Ile Lys Leu Thr Asp 340 345 350 Pro Lys Thr Phe Cys Ala Glu Ala Gin Lys Thr Leu Ser Ile Phe Ala 355 360 365 Gin Pro Arg Ala Thr Ile Phe Phe Glu Gin Leu Gly Asp Arg Val Arg Leu Ala Glu Arg Leu Ser Glu Lys Asp Phe Lys Lys Tyr Leu Thr Gly 385 1324 976 PRT Tannerella sp. 1324 Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Ser Asn Ser Ile Gly Trp Page 3702 of 3790 Glu Cys Lys Leu Val Gly Leu Lys Arg Thr Val Lys Lys Glu Glu Gin 260 265 270 Arg Lys Glu Asn Tyr Cys Trp Arg Val Gin Ala Leu Thr Glu Gin Leu 275 280 285 Asp Leu Glu Lys Val Ala Val Val Leu Gin Glu Ile Asn Gly Gin Ile 290 295 300 Ser Thr Ser Ser Gly Tyr Leu Gly Ala Ile Ser Asp Arg Ser Lys Val 305 310 315 320 Leu Tyr Phe Asn Arg Gin Thr Val Gly Gin Tyr Gin Met Ala Glu Leu 325 330 335 Glu Lys Asn Pro Asn Thr Ser Leu Arg Asn Met Val Phe Tyr Arg Gin 340 345 350 Asp Tyr Leu Asp Glu Phe Asp Lys Ile Trp Glu Lys Gin Ala Glu Phe 355 360 365 His Lys Glu Leu Thr Val Glu Leu Lys Lys Glu Ile Arg Asp Ile Ile 370 375 380 Ile Phe Tyr Gin Arg Arg Leu Lys Ser Gin Lys Gly Leu Ile Gly Phe 385 390 395 400 Cys Glu Phe Glu Asn Arg Glu Ile Met Val Glu Lys Asn Gly Lys Met 405 410 415 Gin Ala Lys Val Val Gly Cys Lys Val Ile Pro Arg Ser His Pro Leu 420 425 430 Phe Gin Glu Phe Lys Ile Trp Gin Thr Leu Asn Asn Val Glu Val Phe 435 440 445 Ala Gly Glu Lys Lys Cys Lys Arg Lys Arg Thr Asp Ala Phe Pro Gly 450 455 460 Leu Phe Asp Gly Thr Glu Asp Thr Leu Met Val Glu Gly Trp Arg Tyr 465 470 475 480 Leu Tyr Gin Glu Glu Lys Glu Ile Leu Ala Lys Glu Leu Ser Val Lys 485 490 495 Lys Ser Leu Lys Lys Glu Tyr Ile Leu Lys Leu Leu Phe Asp Asn Pro 500 505 510 Page 3703 of 3790 Gin Asp Leu Asp Met Asn Phe Glu Gin Ile Glu Gly Asn Asp Thr Gly 515 520 525 Asn Val Leu Phe Ser Ala Tyr Ser Lys Met Ile Glu Lys Tyr Gly Tyr 530 535 540 Glu Pro Leu Asp Phe Gly Lys Pro Thr Asp Lys Ile Ile Glu Gin Leu 545 550 555 560 Gin Val Ile Phe Ala Asp Leu Gly Trp Asn Thr Asp Leu Leu Phe Val 565 570 575 Asp Leu Asn Lys Glu Gly Lys Asp Leu Glu Lys Gin Pro Tyr Phe Lys 580 585 590 Leu Trp His Leu Leu Tyr Ser Phe Glu Gly Asp Asn Thr Pro Thr Gly 595 600 605 Asn Gly Lys Leu Val Glu Lys Leu Met Glu Leu Cys His Val Gly Lys 610 615 620 Glu Cys Ala Leu Glu Leu Val Asn Ile Ser Phe Gin Asn Asp Tyr Gly 625 630 635 640 Ser Leu Ser Ala Lys Ala Ile Lys Lys Ile Leu Pro Tyr Leu Lys Glu 645 650 655 Gly Asn Arg Tyr Asp Val Ala Cys Gly Tyr Ala Gly Tyr Arg His Ser 660 665 670 Lys Ser Ser Leu Thr Lys Glu Glu Ile Glu Asn Lys Val Leu Lys Asp 675 680 685 Lys Leu Asp Ile Leu Pro Lys Asn Ser Leu Arg Asn Pro Val Val Glu 690 695 700 Lys Ile Leu Asn Gin Met Val Asn Val Ile Asn Ala Ile Ile Asp Thr 705 710 715 720 Tyr Gly Lys Pro Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Lys 725 730 735 Lys Ser Ala Lys Glu Arg Glu Glu Leu Thr Lys Ala Ile Ala Lys Ser 740 745 750 Thr Arg Glu His Glu Glu Ile Arg Lys Val Leu Gin Glu Glu Phe Gly 755 760 765 Page 3704 of 3790 Page 3705 of 3790 Cys Gly Trp Ala Val Leu Arg His Ala Asp Ala Ala Gly Glu Pro Gly 20 25 30 Val Ile Glu Gly Leu Gly Ser Trp Cys Phe Asp Val Pro Glu Thr Ser 35 40 45 Lys Glu Arg Ile Pro Thr Asn Gin Val Arg Arg Ser Asn Arg Leu Leu 50 55 60 Arg Arg Val Ile Arg Arg Arg Arg Asn Arg Met Ala Glu Ile Arg Arg 65 70 75 80 Leu Phe His Ala Gin Gly Leu Leu Pro Ser Ala Asp Glu Asp Ala Leu 85 90 95 Lys Arg Pro Arg Leu Asp Pro Trp Glu Leu Arg Ala Arg Gly Leu Asp 100 105 110 Gin Cys Leu Ser Ala Glu Glu Phe Ala Val Ala Leu Gly His Ile Ala 115 120 125 Arg His Arg Gly Phe Arg Ser Ser Ala Lys Arg Lys Ala Ala Asn Thr 130 135 140 Ser Gly Glu Asp Ser Lys Met Leu Ser Ala Leu Leu Val Thr Arg Glu 145 150 155 160 Arg Thr Ala Arg Tyr Arg Thr Val Gly Glu Met Phe Ala Arg Asp Pro 165 170 175 Glu Tyr Ser Ala Arg Arg Arg Asn Arg Asp Gly Ile Phe Asp Arg Thr 180 185 190 Val Ala Arg Asp Asp Leu Ile His Glu Val Gly Lys Leu Phe Glu Ala 195 200 205 Gin Arg Ala Arg Gly Ser Ala Phe Ala Ser Pro Asp Leu Glu Ala Asp 210 215 220 Phe Asn Ala Ile Ala Phe Arg Gin Ala Glu Met Gin Asp Ser Glu Arg 225 230 235 240 Leu Val Gly Asn Cys Pro Phe Glu Arg Asp Glu Lys Arg Ala Ala Arg 245 250 255 Trp Ala Pro Ser Phe Glu Arg Phe Arg Leu Leu Thr Arg Leu Ile Asn 485 490 495 Leu Pro Gly Ala Ile His Ile Glu Leu Ala Arg Glu Val Gly Asn Ser 500 505 510 Page 3707 of 3790 Ile Glu Lys Arg Arg Glu Leu Glu Ser Gin Arg Glu Thr Thr Thr Lys 515 520 525 Arg Arg Gin Thr Glu Arg Asp Glu Ile Arg Gly Leu Leu Ala Leu Glu 530 535 540 Asp Val Asp Asp Asp Thr Leu Leu Arg Tyr Arg Leu Trp Lys Glu Gin 545 550 555 560 Gly Gly Lys Cys Leu Tyr Thr Gly Lys Asp Ile His Val Arg Gin Leu 565 570 575 Ile Ala Thr Asp Asn Ser Val Gin Val Asp His Ile Leu Pro Trp Ser 580 585 590 Arg Phe Gly Asp Asp Ser Phe Asn Asn Lys Thr Leu Cys Leu Ala Ser 595 600 605 Ala Asn Gin Arg Lys Arg Gly Gin Thr Pro Trp Glu Trp Phe Ser Leu 610 615 620 Thr Gly Thr Pro Glu Ala Trp Glu Val Phe Ala Ser Arg Val Glu Thr 625 630 635 640 Ser Lys Asp Leu Arg Gly Phe Lys Lys Arg Asn Leu Leu Leu Lys Asn 645 650 655 Ala Asp Glu Val Ala Gin Arg Phe Arg Ser Arg Asn Leu Asn Asp Thr 660 665 670 Arg Tyr Ala Ala Arg Leu Leu Ala Glu Ala Ala Lys Leu Phe Tyr Pro 675 680 685 Ala Gly Asp Arg Gin Glu Lys Asp Gly Arg Arg Arg Val Leu Thr Arg 690 695 700 Pro Gly Pro Leu Thr Ala Ala Leu Arg His Ala Trp Gly Leu Glu Ser 705 710 715 720 Leu Lys Lys Ala Asp Gly Lys Arg Val Ser Asp Asp Arg His His Ala 725 730 735 Leu Asp Ala Leu Ala Val Ala Ala Ile Ser Glu Arg Glu Val Gin Arg 740 745 750 Leu Thr Arg Ser Phe Gin Glu Trp Glu Gin Gin Gly Leu Ala Arg Pro 755 760 765 Page 3708 of 3790 Page 3709 of 3790 Phe Gly Val Arg Thr Glu Val Lys Ser Glu Val Arg Thr Trp His 1025 1030 1035 Gly Glu Val Cys Thr Ser Pro Val Pro Pro Asp 1040 1045 1326 1395 PRT Treponema denticola 1326 Met Lys Lys Glu Ile Lys Asp Tyr 1 5 Phe Leu Gly Leu Asp Val Gly Thr 10 15 Gly Ser Val Gly Trp Ala Val Thr 20 Asp Thr Asp Tyr Lys Leu Leu Lys 25 30 Ala Asn Arg Lys Asp Leu Trp Gly 35 40 Met Arg Cys Phe Glu Thr Ala Glu 45 Thr Ala Glu Val Arg Arg Leu His 50 55 Arg Gly Ala Arg Arg Arg Ile Glu 60 Arg Arg Lys Lys Arg Ile Lys Leu 65 70 Leu Gin Glu Leu Phe Ser Gin Glu 75 80 Ile Ala Lys Ile Asp Glu Gly Phe 85 Phe Gin Arg Met Lys Glu Ser Pro 90 95 Phe Tyr Ala Glu Asp Lys Thr Ile 100 Leu Gin Glu Asn Ala Leu Phe Asn 105 110 Asp Lys Asp Phe Thr Asp Lys Thr 115 120 Tyr His Lys Ala Tyr Pro Thr Ile 125 Asn His Leu Ile Lys Ala Trp Ile 130 135 Glu Asn Lys Val Lys Pro Asp Pro 140 Arg Leu Leu Tyr Leu Ala Cys His 145 150 Asn Ile Ile Lys Lys Arg Gly His 155 160 Phe Leu Phe Glu Gly Asp Phe Asp 165 Ser Glu Asn Gin Phe Asp Thr Ser 170 175 Ile Gin Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 180 185 190 Page 3710 of 3790 Asp Ala Asp Ser Gin Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 195 200 205 Lys Asn Ser Glu Lys Gin Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 210 215 220 Pro Ser Asp Lys Gin Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 245 250 255 Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 260 265 270 Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 275 280 285 Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 290 295 300 Glu Gin Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 305 310 315 320 Thr Asp Leu Thr Lys Leu Lys Ala Val Ile Lys Lys His Phe Pro Asn 325 330 335 Asn Tyr Lys Lys Val Phe Gly Tyr Asn Gin Asp Asn Glu Ser Lys Asn 340 345 350 Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Asn Lys Lys Leu 355 360 365 Val Ile Asn Asn Ser Val Asn Gin Glu Asp Phe Tyr Lys Phe Leu Lys 370 375 380 Pro Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 385 390 395 400 Ala Glu Ile Glu Thr Gly Asn Phe Leu Pro Lys Gin Ile Ser Lys Ser 405 410 415 Asn Ala Glu Ile Pro Tyr Gin Leu Arg Lys Met Glu Leu Glu Lys Ile 420 425 430 Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gin Lys Asp Glu Page 3711 of 3790 435 440 445 Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 450 455 460 Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 465 470 475 480 Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 485 490 495 Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 500 505 510 Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 515 520 525 Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 530 535 540 Leu Asn Glu Ile Asn Asn Leu Gin Ile Ile Ile Asp Gly Lys Asn Ile 545 550 555 560 Cys Asp Thr Lys Leu Lys Gin Lys Ile Tyr Glu Asp Leu Phe Lys Lys 565 570 575 Tyr Lys Lys Ile Thr Gin Lys Gin Ile Ser Thr Phe Ile Lys His Glu 580 585 590 Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 595 600 605 Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 610 615 620 Gly Lys Gin Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 625 630 635 640 Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 645 650 655 Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gin 660 665 670 Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 675 680 685 Page 3712 of 3790 Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 690 695 700 Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gin Asn Asn Leu Met 705 710 715 720 Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 725 730 735 Asn Ser Gly Phe Glu Asp Ala Glu Lys Gin Phe Ser Tyr Asp Gly Leu 740 745 750 Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gin 755 760 765 Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gin Ala Pro Pro 770 775 780 Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 785 790 795 800 Arg Thr Lys Thr Arg Leu Lys Ile Leu Gin Asp Leu Tyr Ser Ser Cys 805 810 815 Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Gin Tyr Leu Ser Gly 820 825 830 Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 835 840 845 Leu Tyr Tyr Thr Gin Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 850 855 860 Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 865 870 875 880 Tyr Pro Gin Ser Lys Ile Lys Asp Asp Ser Ile Ser Asn Arg Val Leu 885 890 895 Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys Tyr Pro Leu Lys 900 905 910 Ser Glu Ile Gin Ser Lys Gin Arg Gly Phe Trp Asn Phe Leu Gin Arg 915 920 925 Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu Thr Arg Thr Thr 930 935 940 Page 3713 of 3790 Page 3714 of 3790 1327 769 PRT Treponema denticola Page 3715 of 3790 1327 Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 15 10 15 Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 20 25 30 Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 35 40 45 Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 50 55 60 Arg Arg Lys Lys Arg Ile Lys Leu Leu Gin Glu Leu Phe Ser Gin Glu 65 70 75 80 Ile Ala Lys Ile Asp Glu Gly Phe Phe Gin Arg Met Lys Glu Ser Pro 85 90 95 Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gin Glu Asn Ala Leu Phe Asn 100 105 110 Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 115 120 125 Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 130 135 140 Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 145 150 155 160 Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gin Phe Asp Thr Ser 165 170 175 Ile Gin Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 180 185 190 Asp Ala Asp Ser Gin Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 195 200 205 Lys Asn Ser Glu Lys Gin Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 210 215 220 Pro Ser Asp Lys Gin Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 485 490 495 Page 3717 of 3790 Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 500 505 510 Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 515 520 525 Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 530 535 540 Leu Asn Glu Ile Asn Asn Leu Gin Ile Ile Ile Asp Gly Lys Asn Ile 545 550 555 560 Cys Asp Thr Lys Leu Lys Gin Lys Ile Tyr Glu Asp Leu Phe Lys Lys 565 570 575 Tyr Lys Lys Ile Thr Gin Lys Gin Ile Ser Thr Phe Ile Lys His Glu 580 585 590 Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 595 600 605 Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 610 615 620 Gly Lys Gin Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 625 630 635 640 Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 645 650 655 Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gin 660 665 670 Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 675 680 685 Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 690 695 700 Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gin Asn Asn Leu Met 705 710 715 720 Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 725 730 735 Asn Ser Gly Phe Glu Asp Ala Glu Lys Gin Phe Ser Tyr Asp Gly Leu 740 745 750 Page 3718 of 3790 Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Cys Cys Gly Arg 760 765 Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 20 25 30 Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 35 40 45 Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 50 55 60 Arg Arg Lys Lys Arg Ile Lys Leu Leu Gin Glu Leu Phe Ser Gin Glu 65 70 75 80 Ile Ala Lys Ile Asp Glu Gly Phe Phe Gin Arg Met Lys Glu Ser Pro 85 90 95 Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gin Glu Asn Ala Leu Phe Asn 100 105 110 Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 115 120 125 Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 130 135 140 Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 145 150 155 160 Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gin Phe Asp Thr Ser 165 170 175 Ile Gin Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 180 185 190 Page 3719 of 3790 Asp Ala Asp Ser Gin Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 195 200 205 Lys Asn Ser Glu Lys Gin Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 210 215 220 Pro Ser Asp Lys Gin Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 245 250 255 Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 260 265 270 Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 275 280 285 Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 290 295 300 Glu Gin Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 305 310 315 320 Thr Asp Leu Thr Lys Leu Lys Ala Val Ile Lys Lys His Phe Pro Asn 325 330 335 Asn Tyr Lys Lys Val Phe Gly Tyr Asn Gin Asp Asn Glu Ser Lys Asn 340 345 350 Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Asn Lys Lys Leu 355 360 365 Val Ile Asn Asn Ser Val Asn Gin Glu Asp Phe Tyr Lys Phe Leu Lys 370 375 380 Pro Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 385 390 395 400 Ala Glu Ile Glu Thr Gly Asn Phe Leu Pro Lys Gin Ile Ser Lys Ser 405 410 415 Asn Ala Glu Ile Pro Tyr Gin Leu Arg Lys Met Glu Leu Glu Lys Ile 420 425 430 Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gin Lys Asp Glu 435 440 445 Page 3720 of 3790 Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 450 455 460 Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 465 470 475 480 Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 485 490 495 Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 500 505 510 Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 515 520 525 Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 530 535 540 Leu Asn Glu Ile Asn Asn Leu Gin Ile Ile Ile Asp Gly Lys Asn Ile 545 550 555 560 Cys Asp Thr Lys Leu Lys Gin Lys Ile Tyr Glu Asp Leu Phe Lys Lys 565 570 575 Tyr Lys Lys Ile Thr Gin Lys Gin Ile Ser Thr Phe Ile Lys His Glu 580 585 590 Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 595 600 605 Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 610 615 620 Gly Lys Gin Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 625 630 635 640 Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 645 650 655 Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gin 660 665 670 Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 675 680 685 Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu Page 3722 of 3790 Page 3723 of 3790 1329 1395 PRT Treponema denticola 1329 Page 3724 of 3790 Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 15 10 15 Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 20 25 30 Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 35 40 45 Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 50 55 60 Arg Arg Lys Lys Arg Ile Lys Leu Leu Gin Glu Leu Phe Ser Gin Glu 65 70 75 80 Ile Ala Lys Ile Asp Glu Gly Phe Phe Gin Arg Met Lys Glu Ser Pro 85 90 95 Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gin Glu Asn Thr Leu Phe Asn 100 105 110 Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 115 120 125 Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 130 135 140 Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 145 150 155 160 Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gin Phe Asp Thr Ser 165 170 175 Ile Gin Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 180 185 190 Asp Ala Asp Ser Gin Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 195 200 205 Lys Asn Ser Glu Lys Gin Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 210 215 220 Pro Ser Asp Lys Gin Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 245 250 255 Page 3725 of 3790 Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 260 265 270 Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 275 280 285 Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 290 295 300 Glu Gin Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 305 310 315 320 Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 325 330 335 Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 340 345 350 Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 355 360 365 Ile Ile Asn Asn Ser Val Asn Gin Glu Asp Phe Tyr Lys Phe Leu Lys 370 375 380 Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 385 390 395 400 Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gin Ile Ser Lys Ser 405 410 415 Asn Ala Glu Ile Pro Tyr Gin Leu Arg Lys Met Glu Leu Glu Lys Ile 420 425 430 Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gin Lys Asp Glu 435 440 445 Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 450 455 460 Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 465 470 475 480 Pro Asp Arg Cys Trp Val Ile Lys Lys Glu Lys Ser Pro Ser Gly Lys 485 490 495 Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Asp Lys Thr Ala 725 730 735 Asn Ser Gly Phe Glu Asp Ala Glu Lys Gin Phe Ser Tyr Asn Gly Leu 740 745 750 Page 3727 of 3790 Page 3728 of 3790 Page 3729 of 3790 1330 1395 PRT Treponema denticola Page 3730 of 3790 Arg Arg Lys Lys Arg Ile Lys Leu Leu Gin Glu Leu Phe Ser Gin Glu 65 70 75 80 Ile Ala Lys Ile Asp Glu Gly Phe Phe Gin Arg Met Lys Glu Ser Pro 85 90 95 Leu Tyr Ala Glu Asp Lys Thr Ile Leu Gin Glu Asn Thr Leu Phe Asn 100 105 110 Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 115 120 125 Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 130 135 140 Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 145 150 155 160 Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gin Phe Asp Thr Ser 165 170 175 Ile Gin Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Leu Asp Ile 180 185 190 Asp Ala Asp Ser Gin Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 195 200 205 Lys Asn Ser Glu Lys Gin Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 210 215 220 Pro Ser Asp Lys Gin Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 245 250 255 Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 260 265 270 Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 275 280 285 Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 290 295 300 Glu Gin Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys Page 3732 of 3790 Cys Asp Ile Lys Leu Lys Gin Lys Ile Tyr Glu Glu Leu Phe Lys Lys 565 570 575 Tyr Lys Lys Ile Thr Gin Lys Gin Ile Ser Thr Phe Ile Lys His Glu 580 585 590 Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 595 600 605 Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 610 615 620 Gly Lys Gin Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 625 630 635 640 Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 645 650 655 Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gin 660 665 670 Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 675 680 685 Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 690 695 700 Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gin Asn Asn Leu Met 705 710 715 720 Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 725 730 735 Asn Ser Gly Phe Glu Asp Ala Glu Lys Gin Phe Ser Tyr Asn Gly Leu 740 745 750 Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gin 755 760 765 Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gin Ala Pro Pro 770 775 780 Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Glu Pro Ala 785 790 795 800 Arg Thr Lys Thr Arg Leu Lys Ile Leu Gin Asp Leu Tyr Ser Ser Cys 805 810 815 Page 3733 of 3790 Val Phe Asp Tyr Asp Val Lys Arg Asn Asn Ile Thr Ala Trp Glu 1055 1060 1065 Page 3734 of 3790 Met Leu Leu Thr Lys His Lys Asp Thr Ile Tyr Lys Lys Arg Pro 1295 Page 3735 of 3790 1300 1305 Asn Ser Ala Thr Ile Asp Ile Leu Val Lys Gly Lys Glu Lys Phe 1310 1315 1320 Lys Ser Leu Ile Ile Glu Asn Gin Phe Glu Val Ile Leu Glu Ile 1325 1330 1335 Leu Lys Leu Phe Ser Ala Thr Arg Asn Val Ser Asp Leu Gin His 1340 1345 1350 Ile Gly Gly Ser Lys Asn Ala Gly Asn Ala Arg Val Gly Asn Lys 1355 1360 1365 Ile Ser Ser Leu Asp Asn Cys Ile Leu Ile Tyr Gin Ser Ile Thr 1370 1375 1380 Gly Ile Phe Glu Lys Arg Ile Asp Leu Leu Lys Ile 1385 1390 1395 Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 20 25 30 Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 35 40 45 Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 50 55 60 Arg Arg Lys Lys Arg Ile Lys Leu Leu Gin Glu Leu Phe Ser Gin Glu 65 70 75 80 Ile Ala Lys Ile Asp Glu Gly Phe Phe Gin Arg Met Lys Glu Ser Pro 85 90 95 Leu Tyr Ala Glu Asp Lys Thr Ile Leu Gin Glu Asn Thr Leu Phe Asn 100 105 110 Asp Lys Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile Page 3736 of 3790 115 120 125 Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 130 135 140 Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 145 150 155 160 Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gin Phe Asp Thr Ser 165 170 175 Ile Gin Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 180 185 190 Asp Ala Asp Ser Gin Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 195 200 205 Lys Asn Ser Glu Lys Gin Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 210 215 220 Pro Ser Asp Lys Gin Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 245 250 255 Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 260 265 270 Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 275 280 285 Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 290 295 300 Glu Gin Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 305 310 315 320 Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 325 330 335 Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 340 345 350 Asn Tyr Ser Gly Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 355 360 365 Page 3737 of 3790 Ile Ile Asn Asn Ser Val Asn Gin Glu Asp Phe Tyr Lys Phe Leu Lys 370 375 380 Thr Ile Leu Ser Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 385 390 395 400 Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gin Ile Ser Lys Ser 405 410 415 Asn Ala Glu Ile Pro Tyr Gin Leu Arg Lys Met Glu Leu Glu Lys Ile 420 425 430 Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gin Lys Asp Glu 435 440 445 Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 450 455 460 Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 465 470 475 480 Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly Lys 485 490 495 Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr Ala 500 505 510 Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Ile Gly 515 520 525 Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 530 535 540 Leu Asn Glu Ile Asn Asn Leu Gin Ile Ile Ile Asp Gly Lys Asn Ile 545 550 555 560 Cys Asp Thr Lys Leu Lys Gin Lys Ile Tyr Glu Glu Leu Phe Lys Lys 565 570 575 Tyr Lys Lys Ile Thr Gin Lys Gin Ile Ser Thr Phe Ile Lys His Glu 580 585 590 Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 595 600 605 Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 610 615 620 Page 3738 of 3790 Gly Lys Gin Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 625 630 635 640 Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 645 650 655 Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gin 660 665 670 Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 675 680 685 Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 690 695 700 Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gin Asn Asn Leu Met 705 710 715 720 Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 725 730 735 Asn Ser Gly Phe Glu Asp Val Glu Lys Gin Phe Ser Tyr Asp Gly Leu 740 745 750 Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gin 755 760 765 Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gin Ala Pro Pro 770 775 780 Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Asp Pro Val 785 790 795 800 Arg Thr Lys Thr Arg Leu Lys Ile Leu Gin Asp Leu Tyr Asn Asn Cys 805 810 815 Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Lys Asp Leu Ser Gly 820 825 830 Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser Asp Lys Leu Tyr 835 840 845 Leu Tyr Tyr Thr Gin Leu Gly Lys Cys Met Tyr Cys Gly Lys Pro Ile 850 855 860 Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp Ile Asp His Ile 865 870 875 880 Page 3739 of 3790 Lys Lys Glu Gly Pro Phe Ser Asn Ile Ser Lys Tyr Gly Gly Tyr Page 3741 of 3790 1332 357 PRT Treponema denticola 1332 Page 3742 of 3790 Ile Gin Ala Phe Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 180 185 190 Asp Ala Asp Ser Gin Lys Ile Lys Glu Ile Leu Lys Asp Ser Ser Leu 195 200 205 Lys Asn Ser Glu Lys Gin Ser Arg Leu Asn Lys Ile Leu Gly Leu Lys 210 215 220 Ser Ser Asp Lys Gin Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 245 250 255 Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 260 265 270 Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 275 280 285 Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 290 295 300 Glu Gin Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 305 310 315 320 Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Lys 325 330 335 Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Ile Thr Thr 340 345 350 Ile Thr Pro Asp Met 355 1333 1395 PRT Treponema denticola 1333 Met Lys Lys Glu Ile Lys Asp Tyr Phe Leu Gly Leu Asp Val Gly Thr 15 10 15 Gly Ser Val Gly Trp Ala Val Thr Asp Thr Asp Tyr Lys Leu Leu Lys 20 25 30 Page 3743 of 3790 Ala Asn Arg Lys Asp Leu Trp Gly Met Arg Cys Phe Glu Thr Ala Glu 35 40 45 Thr Ala Glu Val Arg Arg Leu His Arg Gly Ala Arg Arg Arg Ile Glu 50 55 60 Arg Arg Lys Lys Arg Ile Lys Leu Leu Gin Glu Leu Phe Ser Gin Glu 65 70 75 80 Ile Ala Lys Thr Asp Glu Gly Phe Phe Gin Arg Met Lys Glu Ser Pro 85 90 95 Phe Tyr Ala Glu Asp Lys Thr Ile Leu Gin Glu Asn Ala Leu Phe Asn 100 105 110 Asp Arg Asp Phe Thr Asp Lys Thr Tyr His Lys Ala Tyr Pro Thr Ile 115 120 125 Asn His Leu Ile Lys Ala Trp Ile Glu Asn Lys Val Lys Pro Asp Pro 130 135 140 Arg Leu Leu Tyr Leu Ala Cys His Asn Ile Ile Lys Lys Arg Gly His 145 150 155 160 Phe Leu Phe Glu Gly Asp Phe Asp Ser Glu Asn Gin Phe Asp Thr Ser 165 170 175 Ile Gin Ala Leu Phe Glu Tyr Leu Arg Glu Asp Met Glu Val Asp Ile 180 185 190 Asp Ala Asp Ser Gin Lys Val Lys Glu Ile Leu Lys Asp Ser Ser Leu 195 200 205 Lys Asn Ser Glu Lys Gin Ser Arg Leu Asn Lys Met Leu Gly Leu Lys 210 215 220 Pro Ser Asp Lys Gin Lys Lys Ala Ile Thr Asn Leu Ile Ser Gly Asn 225 230 235 240 Lys Ile Asn Phe Ala Asp Leu Tyr Asp Asn Pro Asp Leu Lys Asp Ala 245 250 255 Glu Lys Asn Ser Ile Ser Phe Ser Lys Asp Asp Phe Asp Ala Leu Ser 260 265 270 Asp Asp Leu Ala Ser Ile Leu Gly Asp Ser Phe Glu Leu Leu Leu Lys 275 280 285 Page 3744 of 3790 Ala Lys Ala Val Tyr Asn Cys Ser Val Leu Ser Lys Val Ile Gly Asp 290 295 300 Glu Gin Tyr Leu Ser Phe Ala Lys Val Lys Ile Tyr Glu Lys His Lys 305 310 315 320 Thr Asp Leu Thr Lys Leu Lys Asn Val Ile Lys Lys His Phe Pro Asn 325 330 335 Asp Tyr Lys Lys Val Phe Gly Tyr Asn Lys Asn Glu Lys Asn Asn Asn 340 345 350 Asn Tyr Ser Ala Tyr Val Gly Val Cys Lys Thr Lys Ser Lys Lys Leu 355 360 365 Val Ile Asn Asn Thr Val Asn Gin Glu Asp Phe Tyr Lys Phe Leu Lys 370 375 380 Pro Ile Leu Leu Ala Lys Ser Glu Ile Lys Glu Val Asn Asp Ile Leu 385 390 395 400 Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gin Ile Ser Lys Ser 405 410 415 Asn Ala Glu Ile Pro Tyr Gin Leu Arg Lys Met Glu Leu Glu Lys Ile 420 425 430 Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gin Lys Asp Glu 435 440 445 Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe Lys 450 455 460 Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser Phe 465 470 475 480 Pro Asp Arg Cys Trp Val Ile Lys Lys Glu Lys Ser Pro Ser Gly Lys 485 490 495 Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Asp Lys Thr Ala 500 505 510 Glu Ala Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val Gly 515 520 525 Glu Ser Val Leu Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Thr Val 530 535 540 Page 3745 of 3790 Leu Asn Glu Ile Asn Asn Leu Gin Ile Ile Ile Asp Gly Lys Asn Ile 545 550 555 560 Cys Asp Ile Lys Leu Lys Gin Lys Ile Tyr Glu Glu Leu Phe Lys Lys 565 570 575 Tyr Lys Lys Ile Thr Gin Lys Gin Ile Ser Thr Phe Ile Lys His Glu 580 585 590 Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp Lys 595 600 605 Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile Phe 610 615 620 Gly Lys Gin Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Glu Ile 625 630 635 640 Ile Arg Trp Ala Thr Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile Leu 645 650 655 Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu Gin 660 665 670 Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu Ser 675 680 685 Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser Glu 690 695 700 Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gin Asn Asn Leu Met 705 710 715 720 Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys Ile 725 730 735 Asn Ser Gly Phe Glu Asp Val Glu Lys Gin Phe Ser Tyr Asp Ser Leu 740 745 750 Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Met Leu Trp Gin 755 760 765 Thr Leu Lys Leu Val Lys Glu Ile Ser His Ile Thr Gin Ala Pro Pro 770 775 780 Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu Leu Asp Pro Val Phe Arg Asn Lys Phe Asp Ile Ile Lys Cys Arg Glu Ile Asn Asp Phe 995 1000 1005 His His Ala His Asp Ala Tyr Leu Asn Ile Val Val Gly Asn Val 1010 1015 1020 Tyr Asn Thr Lys Phe Thr Asn Asn Pro Trp Asn Phe Ile Lys Glu 1025 1030 1035 Page 3748 of 3790 1334 631 PRT Treponema denticola 1334 Page 3749 of 3790 Gly Lys Pro Ile Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp 100 105 110 Ile Asp His Ile Tyr Pro Gin Ser Lys Ile Lys Asp Asp Ser Ile Ser 115 120 125 Asn Arg Val Leu Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys 130 135 140 Tyr Pro Leu Arg Ser Glu Ile Gin Ser Lys Gin Arg Gly Phe Trp Asn 145 150 155 160 Phe Leu Gin Arg Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu 165 170 175 Thr Arg Thr Thr Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala 180 185 190 Arg Gin Leu Val Glu Thr Arg Gin Ala Thr Lys Val Ala Ala Lys Val 195 200 205 Leu Glu Lys Met Phe Pro Glu Thr Lys Ile Val Tyr Ser Lys Ala Glu 210 215 220 Thr Val Ser Met Phe Arg Asn Lys Phe Asp Ile Val Lys Cys Arg Glu 225 230 235 240 Ile Asn Asp Phe His His Ala His Asp Ala Tyr Leu Asn Ile Val Val 245 250 255 Gly Asn Ile Tyr Asn Thr Lys Phe Thr Asn Asn Pro Trp Asn Phe Ile 260 265 270 Lys Glu Lys Arg Asp Asn Pro Lys Ile Ala Asp Thr Tyr Asn Tyr Tyr 275 280 285 Lys Val Phe Asp Tyr Asp Val Lys Arg Asn Asn Ile Thr Ala Trp Glu 290 295 300 Lys Gly Lys Thr Ile Ile Thr Val Lys Asp Met Leu Lys Arg Asn Thr 305 310 315 320 Pro Ile Tyr Thr Arg Gin Ala Ala Cys Lys Lys Gly Gly Leu Phe Asp 325 330 335 Gin Thr Ile Met Lys Lys Gly Leu Gly Gin His Pro Leu Lys Lys Glu 340 345 350 Page 3750 of 3790 Gly Pro Phe Ser Asn Ile Ser Lys Tyr Gly Gly Tyr Asn Lys Val Ser 355 360 365 Ala Ala Tyr Tyr Thr Leu Ile Glu Tyr Glu Glu Lys Glu Asn Lys Ile 370 375 380 Arg Ser Leu Glu Thr Ile Pro Leu Tyr Leu Val Lys Asp Ile Gin Lys 385 390 395 400 Ser Gin Glu Lys Leu Lys Ser Tyr Leu Thr Asp Leu Leu Gly Lys Lys 405 410 415 Glu Ile Lys Ile Leu Val Pro Lys Ile Lys Ile Asn Ser Leu Leu Lys 420 425 430 Ile Asn Gly Phe Pro Cys His Ile Thr Gly Lys Thr Asn Asp Ser Phe 435 440 445 Leu Leu Arg Pro Ala Val Gin Phe Cys Cys Ser Asn Asp Glu Val Leu 450 455 460 Tyr Phe Lys Lys Ile Ile Arg Phe Asn Glu Ile Arg Ser Gin Arg Glu 465 470 475 480 Lys Met Gly Lys Thr Ile Ser Pro Tyr Glu Asp Leu Ser Phe Arg Ser 485 490 495 Tyr Ile Lys Glu Asn Leu Cys Lys Lys Thr Lys Asn Asp Glu Ile Gly 500 505 510 Glu Lys Glu Phe Tyr Asp Leu Leu Gin Lys Lys Asn Leu Glu Ile Tyr 515 520 525 Asp Met Leu Leu Thr Lys His Lys Asp Thr Ile Tyr Asn Lys Arg Pro 530 535 540 Asn Ser Thr Thr Leu Gly Met Leu Thr Lys Gly Arg Tyr Glu Phe Ile 545 550 555 560 Asn Leu Lys Pro Lys Asp Gin Ile Ile Val Met Leu Glu Ile Leu Lys 565 570 575 Leu Phe Cys Thr Thr Arg Glu Ala Ile Asp Leu Gly Leu Ile Lys Gly 580 585 590 Lys Pro Ala Ala Gly Val Ala Thr Leu Gly Lys Lys Ile Ser Asn Leu Page 3751 of 3790 595 600 605 Asp Asn Cys Ile Leu Ile Tyr Gin Ser Ile Thr Gly Ile Phe Glu Lys 610 615 620 Arg Ile Asp Leu Leu Lys Val Gin Ala Pro Pro Lys Lys Ile Phe Ile Glu Met Ala Lys Gly Ala Glu 20 25 30 Leu Glu Pro Ala Arg Thr Lys Thr Arg Leu Lys Ile Leu Gin Asp Leu 35 40 45 Tyr Ser Ser Cys Lys Asn Asp Ala Asp Ala Phe Ser Ser Glu Ile Gin 50 55 60 Tyr Leu Ser Gly Lys Ile Glu Asn Glu Asp Asn Leu Arg Leu Arg Ser 65 70 75 80 Asp Lys Leu Tyr Leu Tyr Tyr Thr Gin Leu Gly Lys Cys Met Tyr Cys 85 90 95 Gly Lys Pro Ile Glu Ile Gly His Val Phe Asp Thr Ser Asn Tyr Asp 100 105 110 Ile Asp His Ile Tyr Pro Gin Ser Lys Ile Lys Asp Asp Ser Ile Ser 115 120 125 Asn Arg Val Leu Val Cys Ser Ser Cys Asn Lys Asn Lys Glu Asp Lys 130 135 140 Tyr Pro Leu Lys Ser Glu Ile Gin Ser Lys Gin Arg Gly Phe Trp Asn 145 150 155 160 Phe Leu Gin Arg Asn Asn Phe Ile Ser Leu Glu Lys Leu Asn Arg Leu 165 170 175 Thr Arg Thr Thr Pro Ile Ser Asp Asp Glu Thr Ala Lys Phe Ile Ala 405 410 415 Glu Ile Lys Ile Leu Val Pro Lys Ile Lys Ile Asn Ser Leu Leu Lys 420 425 430 Page 3753 of 3790 Ile Asn Gly Phe Pro Cys His Ile Thr Gly Lys Thr Gly Asp Ser Phe 435 440 445 Val Leu Arg Pro Ala Val Gin Phe Cys Cys Ser Asn Asp Glu Val Leu 450 455 460 Tyr Phe Lys Lys Ile Ile Arg Phe Asn Glu Ile Arg Ser Gin Arg Glu 465 470 475 480 Lys Met Gly Lys Thr Ile Ser Pro Tyr Glu Asp Leu Ser Phe Arg Ser 485 490 495 Tyr Ile Lys Glu Asn Leu Cys Lys Lys Thr Lys Ala Asp Glu Ile Gly 500 505 510 Glu Lys Glu Phe Tyr Asp Leu Leu Gin Lys Lys Asn Leu Glu Ile Tyr 515 520 525 Asp Met Leu Leu Thr Lys His Lys Asp Thr Ile Tyr Asn Lys Arg Pro 530 535 540 Asn Ser Thr Thr Leu Gly Met Leu Thr Lys Gly Arg Tyr Glu Phe Ile 545 550 555 560 Asn Leu Lys Pro Lys Asp Gin Ile Ile Val Met Leu Glu Ile Leu Lys 565 570 575 Leu Phe Cys Thr Thr Arg Glu Ala Ile Asp Leu Gly Leu Ile Lys Gly 580 585 590 Lys Pro Ala Ala Gly Val Ala Thr Leu Gly Lys Lys Ile Ser Asn Leu 595 600 605 Asp Asn Cys Ile Leu Ile Tyr Gin Ser Ile Thr Gly Ile Phe Glu Lys 610 615 620 Arg Ile Asp Leu Leu Lys Val 625 630 1336 370 PRT Treponema denticola 1336 Met Thr Glu Ile Glu Thr Gly Thr Phe Leu Pro Lys Gin Ile Ser Lys 15 10 15 Page 3754 of 3790 Ser Asn Ala Glu Ile Pro Tyr Gin Leu Arg Lys Met Glu Leu Glu Lys 20 25 30 Ile Leu Ser Asn Ala Glu Lys His Phe Ser Phe Leu Lys Gin Lys Asp 35 40 45 Glu Lys Gly Leu Ser His Ser Glu Lys Ile Ile Met Leu Leu Thr Phe 50 55 60 Lys Ile Pro Tyr Tyr Ile Gly Pro Ile Asn Asp Asn His Lys Lys Ser 65 70 75 80 Phe Pro Asp Arg Cys Trp Val Val Lys Lys Glu Lys Ser Pro Ser Gly 85 90 95 Lys Thr Thr Pro Trp Asn Phe Phe Asp His Ile Asp Lys Glu Lys Thr 100 105 110 Ala Glu Glu Phe Ile Thr Ser Arg Thr Asn Phe Cys Thr Tyr Leu Val 115 120 125 Gly Glu Ser Val Leu Pro Lys Ser Ser Leu Leu Tyr Ser Glu Tyr Thr 130 135 140 Val Leu Asn Glu Ile Asn Asn Leu Gin Ile Ile Ile Asp Gly Lys Asn 145 150 155 160 Ile Cys Asp Ile Lys Leu Lys Gin Lys Ile Tyr Glu Glu Leu Phe Lys 165 170 175 Lys Tyr Lys Lys Ile Thr Gin Lys Gin Ile Ser Thr Phe Ile Lys His 180 185 190 Glu Gly Ile Cys Asn Lys Thr Asp Glu Val Ile Ile Leu Gly Ile Asp 195 200 205 Lys Glu Cys Thr Ser Ser Leu Lys Ser Tyr Ile Glu Leu Lys Asn Ile 210 215 220 Phe Gly Lys Gin Val Asp Glu Ile Ser Thr Lys Asn Met Leu Glu Asp 225 230 235 240 Ile Ile Arg Trp Ala Ala Ile Tyr Asp Glu Gly Glu Gly Lys Thr Ile 245 250 255 Leu Lys Thr Lys Ile Lys Ala Glu Tyr Gly Lys Tyr Cys Ser Asp Glu 260 265 270 Page 3755 of 3790 Gin Ile Lys Lys Ile Leu Asn Leu Lys Phe Ser Gly Trp Gly Arg Leu 275 280 285 Ser Arg Lys Phe Leu Glu Thr Val Thr Ser Glu Met Pro Gly Phe Ser 290 295 300 Glu Pro Val Asn Ile Ile Thr Ala Met Arg Glu Thr Gin Asn Asn Leu 305 310 315 320 Met Glu Leu Leu Ser Ser Glu Phe Lys Phe Thr Glu Asn Ile Lys Lys 325 330 335 Ile Asn Ser Gly Phe Glu Asp Val Glu Lys Gin Phe Ser Tyr Asp Gly 340 345 350 Leu Val Lys Pro Leu Phe Leu Ser Pro Ser Val Lys Lys Cys Cys Gly 355 360 365 Arg Leu 370 Ala Ser Ile Lys Ala Leu Tyr Glu Asn Cys Lys Gin Asp Leu Ala Asp 20 25 30 Tyr Asp Ala Val Leu Glu Gin Phe Lys Ser Glu Glu Pro Leu Arg Leu 35 40 45 Arg Ser Asp Lys Leu Tyr Leu Tyr Tyr Thr Gin Leu Gly Arg Cys Met 50 55 60 Tyr Thr Gly Arg Val Ile Asp Ile Asp Arg Leu Met Ser Asp Asn Ser 65 70 75 80 Ala Tyr Asp Ile Asp His Ile Tyr Pro Arg Ser Lys Ile Lys Asp Asp 85 90 95 Ser Leu Thr Asn Arg Val Leu Val Val Lys Asp Ala Asn Gin Asp Lys 100 105 110 Page 3756 of 3790 Arg Asp Glu Pro Leu Ser Pro Gin Ile Gin Asp Lys Gin Lys Gly Phe 115 120 125 Trp Asp Phe Leu Lys His Asn Asn Phe Ile Ser Ile Glu Lys Tyr Glu 130 135 140 Arg Leu Thr Tyr Arg Gly Tyr Phe Thr Glu Glu Met Leu Ser Gly Phe 145 150 155 160 Ile Ala Arg Gin Leu Val Glu Thr Arg Gin Gly Thr Lys Thr Ala Gly 165 170 175 Gin Ile Leu Glu Gin Leu Tyr Pro Asp Ser Thr Val Val Tyr Cys Lys 180 185 190 Ala Ala Asn Thr Ser Glu Phe Arg Gin Lys Phe Asn Leu Ile Lys Cys 195 200 205 Arg Glu Ile Asn Asp Leu His His Ala His Asp Ala Tyr Leu Asn Ile 210 215 220 Ala Val Gly Asn Val Tyr Tyr Thr Lys Phe Thr Ser Asn Pro Arg Asn 225 230 235 240 Phe Met Lys Leu Lys Glu Pro Tyr Asn Leu Arg Glu Leu Phe Asp Arg 245 250 255 Asp Val Glu Arg Asn Asn Thr Ile Ala Trp Val Lys Asn Lys Thr Ile 260 265 270 Thr Thr Ile Lys Asp Met Leu Lys Arg Asn Thr Pro Leu Tyr Thr Arg 275 280 285 Tyr Ala Tyr Cys Lys Thr Gly Gly Phe Phe Asp Gin Asn Ile Met Lys 290 295 300 Lys Gly Lys Gly Gin Phe Pro Leu Lys Glu Asn Ser Pro Leu Ser Asp 305 310 315 320 Ile Ser Lys Tyr Gly Gly Tyr Asn Lys Val Ser Gly Ala Tyr Phe Ile 325 330 335 Leu Val Gin Lys Lys Glu Lys Asp Ala Val Val Arg Ile Leu Glu Thr 340 345 350 Val Pro Leu Tyr Leu Leu Asn Lys Pro Gly Lys Glu Ser Glu Asn Val 355 360 365 Page 3757 of 3790 Page 3758 of 3790 1338 Met Ile Met Lys Leu Glu Lys Trp Arg Leu Gly Leu Asp Leu Gly Thr 15 10 15 Asn Ser Ile Gly Trp Ser Val Phe Ser Leu Asp Lys Asp Asn Ser Val 20 25 30 Gin Asp Leu Ile Asp Met Gly Val Arg Ile Phe Ser Asp Gly Arg Asp 35 40 45 Pro Lys Thr Lys Glu Pro Leu Ala Val Ala Arg Arg Thr Ala Arg Ser 50 55 60 Gin Arg Lys Leu Ile Tyr Arg Arg Lys Leu Arg Arg Lys Gin Val Phe 65 70 75 80 Lys Phe Leu Gin Glu Gin Gly Leu Phe Pro Lys Thr Lys Glu Glu Cys 85 90 95 Met Thr Leu Lys Ser Leu Asn Pro Tyr Glu Leu Arg Ile Lys Ala Leu 100 105 110 Asp Glu Lys Leu Glu Pro Tyr Glu Leu Gly Arg Ala Leu Phe Asn Leu 115 120 125 Ala Val Arg Arg Gly Phe Lys Ser Asn Arg Lys Asp Gly Ser Arg Glu 130 135 140 Glu Val Ser Glu Lys Lys Ser Pro Asp Glu Ile Lys Thr Gin Ala Asp 145 150 155 160 Met Gin Thr His Leu Glu Lys Ala Ile Lys Glu Asn Gly Cys Arg Thr 165 170 175 Ile Thr Glu Phe Leu Tyr Lys Asn Gin Gly Glu Asn Gly Gly Ile Arg 180 185 190 Phe Ala Pro Gly Arg Met Thr Tyr Tyr Pro Thr Arg Lys Met Tyr Glu 195 200 205 Glu Glu Phe Asn Leu Ile Arg Ser Lys Gin Glu Lys Tyr Tyr Pro Gin 210 215 220 Val Asp Trp Asp Asp Ile Tyr Lys Ala Ile Phe Tyr Gin Arg Pro Leu 225 230 235 240 Lys Pro Gin Gin Arg Gly Tyr Cys Ile Tyr Glu Asn Asp Lys Glu Arg Page 3760 of 3790 Leu Ile Lys Glu Tyr Gly Lys Pro Ser Gin Ile Ala Ile Glu Leu Ser 500 505 510 Arg Asp Leu Lys Asn Asn Val Glu Lys Lys Ala Glu Ile Ala Arg Lys 515 520 525 Gin Asn Gin Arg Ala Lys Glu Asn Ile Ala Ile Asn Asp Thr Ile Ser 530 535 540 Ala Leu Tyr His Thr Ala Phe Pro Gly Lys Ser Phe Tyr Pro Asn Arg 545 550 555 560 Asn Asp Arg Met Lys Tyr Arg Leu Trp Ser Glu Leu Gly Leu Gly Asn 565 570 575 Lys Cys Ile Tyr Cys Gly Lys Gly Ile Ser Gly Ala Glu Leu Phe Thr 580 585 590 Lys Glu Ile Glu Ile Glu His Ile Leu Pro Phe Ser Arg Thr Leu Leu 595 600 605 Asp Ala Glu Ser Asn Leu Thr Val Ala His Ser Ser Cys Asn Ala Phe 610 615 620 Lys Ala Glu Arg Ser Pro Phe Glu Ala Phe Gly Thr Asn Pro Ser Gly 625 630 635 640 Tyr Ser Trp Gin Glu Ile Ile Gin Arg Ala Asn Gin Leu Lys Asn Thr 645 650 655 Ser Lys Lys Asn Lys Phe Ser Pro Asn Ala Met Asp Ser Phe Glu Lys 660 665 670 Asp Ser Ser Phe Ile Ala Arg Gin Leu Ser Asp Asn Gin Tyr Ile Ala 675 680 685 Lys Ala Ala Leu Arg Tyr Leu Lys Cys Leu Val Glu Asn Pro Ser Asp 690 695 700 Val Trp Thr Thr Asn Gly Ser Met Thr Lys Leu Leu Arg Asp Lys Trp 705 710 715 720 Glu Met Asp Ser Ile Leu Cys Arg Lys Phe Thr Glu Lys Glu Val Ala 725 730 735 Leu Leu Gly Leu Lys Pro Glu Gin Ile Gly Asn Tyr Lys Lys Asn Arg 740 745 750 Page 3761 of 3790 Page 3762 of 3790 1339 281 PRT Treponema vincentii 1339 Page 3763 of 3790 Page 3764 of 3790 Arg Asp Lys Ile Leu Leu Glu Thr Asn Asp Lys Pro Ser Gly Ser Thr 100 105 110 Asp Lys Lys Thr Asp Pro Tyr Ser Leu Arg Ala Arg Ala Leu Glu Glu 115 120 125 Lys Leu Pro Leu Ala Tyr Val Ala Arg Ala Leu Phe His Ile Gly Gin 130 135 140 Arg Arg Gly Phe Lys Ser Asn Arg Lys Ala Asp Arg Lys Ser Asn Glu 145 150 155 160 Lys Gly Lys Ile Ala Ala Gly Ile Glu Glu Leu Ser Gly Leu Met His 165 170 175 Gin Ser His Ala Pro Thr Leu Gly Ala Tyr Leu Ala Lys Arg Arg Glu 180 185 190 Glu Gly His Val Val Arg Leu Arg Ala Ser Ser Glu Ala Leu Thr Asn 195 200 205 Lys Ala Tyr Ala Phe Tyr Pro Glu Arg Ala Met Leu Glu Asp Glu Phe 210 215 220 His Lys Ile Trp Gin Ala Gin Ala Glu Tyr Tyr Pro Asp Val Leu Thr 225 230 235 240 Lys Glu Arg Glu Glu Glu Leu Phe His Val Met Phe Phe Gin Arg Pro 245 250 255 Leu Lys Glu Gin Lys Val Gly Leu Cys Thr Leu Val Glu Gly Glu Leu 260 265 270 Arg Leu Pro Lys Ser Asp Pro Leu Phe Gin Gin Phe Arg Leu Tyr Lys 275 280 285 Glu Ile Asn Glu Leu Ala Ile Ile Leu Pro Asp Leu Ser Gin Arg Lys 290 295 300 Leu Thr Met Glu Glu Arg Asp Thr Leu Ile Thr Leu Met Arg Pro Ala 305 310 315 320 Lys Thr Lys Thr Phe Ala Ala Leu Arg Lys Ala Leu Lys Ile Pro Ala 325 330 335 Gly Gly Arg Phe Asn Lys Glu Thr Glu Asn Arg Lys Gin Leu Thr Gly Page 3766 of 3790 Page 3767 of 3790 Asp Lys Lys Ser Gly Leu Phe Trp Gin Gin Lys Pro Ala Leu Ala Gly 130 135 140 Ala Asp Leu Leu Lys Met Leu Gly Thr Cys Thr Phe Glu Lys Asn Glu 145 150 155 160 Tyr Arg Ala Pro Lys Ala Ser Phe Thr Ala Glu Arg His Val Trp Leu 165 170 175 Thr Arg Leu Asn Asn Leu Arg Ile Val Thr Asp Gly Ile Thr Arg Gin 180 185 190 Leu Thr Glu Gin Glu Arg Gin Leu Val Leu Pro Leu Pro Tyr Arg Gin 195 200 205 Ala Gly Asp Leu Thr Tyr Lys Gin Leu Gly Met Ala Leu Thr Lys Ala 210 215 220 Gly Leu Leu Glu Ala Gly Cys Phe Lys Phe Ile Gly Leu Ala Tyr Pro 225 230 235 240 Thr Glu Ala Gin Lys Ala Glu Gly Lys Thr Lys Asp Pro Glu Ser Ala 245 250 255 Thr Leu Val Lys Ile Pro Ala Trp Gin Glu Leu Arg Gin Thr Leu Asn 260 265 270 Lys Ala Ser Leu Asn Asp Glu Trp Glu Lys Leu Ser Gly Asp Ala Leu 275 280 285 Cys Gly Gin Pro Glu Ile Phe Asp Lys Ile Ala Trp Ile Leu Ser Val 290 295 300 Tyr Lys Asp Asp Asp Glu Val Arg Thr Glu Leu Ala Lys Leu Val Leu 305 310 315 320 Pro Asn Pro Glu Gly Leu Thr Glu Ala Leu Leu Asn Ile Arg Phe Asp 325 330 335 Lys Phe His Ala Leu Ser Leu Lys Ala Leu Arg Ala Ile Val Pro His 340 345 350 Met Glu Lys Gly Leu Arg Tyr Asp Glu Ala Cys Val Gin Ala Gly Tyr 355 360 365 His His Ser Gin Leu His Lys Ile Gly Glu Gly Glu His Lys Tyr Leu 370 375 380 Page 3768 of 3790 Pro Pro Leu Tyr Asp Gly Arg Asp Gly Asp Gly Arg Met Ile Phe Ala 385 390 395 400 Glu Asp Ala Asp Ile Pro Arg Asn Pro Val Val Leu Arg Ser Leu Asn 405 410 415 Gin Ala Arg Lys Val Val Asn Ala Ile Ile Arg Arg Tyr Gly Ser Pro 420 425 430 Ser Ala Val His Ile Glu Met Ala Arg Asp Leu Ser Arg Pro Phe Asp 435 440 445 Glu Arg Asn Lys Ile Lys Lys Asp Gin Asp Glu Tyr Gin Ala Arg Asn 450 455 460 Gin Arg Asp Arg Glu Gin Phe Ile Glu Leu Phe Gly His Pro Pro Lys 465 470 475 480 Gly Leu Glu Phe Glu Lys Trp Arg Leu Tyr Arg Glu Gin Asn Gly Gin 485 490 495 Cys Ala Tyr Ser Gin Lys Pro Leu Ala Ser Ser Gly Asp Val Ala Glu 500 505 510 Ile Phe Leu Asp Gly Ser Thr Glu Ile Asp His Ala Leu Pro Tyr Ser 515 520 525 Arg Ser Phe Asp Asp Ser Lys Asn Asn Lys Val Leu Val Leu Thr Arg 530 535 540 Glu Asn Arg Asp Lys Gly Asn Arg Thr Pro Tyr Glu Tyr Leu Gly Gly 545 550 555 560 Ala Glu Asn Ser Glu Arg Trp Gin Arg Phe Phe Ser Phe Val Glu Ser 565 570 575 Asn Lys Ala Tyr Arg Leu Ala Lys Arg Thr Arg Leu Leu Arg Lys Asp 580 585 590 Phe Gly Ala Lys Glu Ser Glu Glu Phe Arg Glu Arg Asn Leu Asn Asp 595 600 605 Thr Arg Tyr Val Cys Arg Phe Phe Lys Asn Tyr Val Glu Gin His Leu 610 615 620 Lys Leu Ala Glu Gly Ser Glu Ala Lys Arg Cys Val Val Val Ser Gly 625 630 635 640 Page 3769 of 3790 Gin Leu Thr Asn Phe Leu Arg Thr Arg Trp Gly Leu Leu Lys Ile Arg 645 650 655 Ser Asp Ser Asp Arg His His Ala Leu Asp Ala Ala Val Val Ala Ala 660 665 670 Cys Ser His Ser Met Val Gin Arg Leu Ser Asn Tyr Ser Arg Thr Arg 675 680 685 Glu Leu Glu Gin Val Arg Asp Gly Phe Val Asn Ile Glu Thr Gly Glu 690 695 700 Ile Val Asn Pro Ala Met His Gin Gin Leu Arg Glu His Phe Pro Asp 705 710 715 720 Pro Trp Pro Tyr Phe Arg His Glu Leu Glu Ala Arg Leu Lys Ile Asp 725 730 735 Ser Pro Ala Leu Leu Arg Glu Glu Met Ala Arg Leu Ser Ser Tyr Thr 740 745 750 Glu Glu Glu Leu Ala Ala Leu Lys Pro Leu Phe Val Ser Arg Ala Pro 755 760 765 Gin Arg Arg Asn Gly Gly Ala Ala His Lys Asp Thr Ile Tyr Gly Gin 770 775 780 Pro Glu Lys Leu Lys Lys Asn Gly Ser Val Ser Gin Lys Val Ala Leu 785 790 795 800 Ala Ser Leu Ala Leu Lys Asp Ile Asp Leu Leu Ala Asp Pro His Arg 805 810 815 Asn Ala Lys Leu Tyr Gly Ala Ile Arg Glu Arg Leu Glu Ala His Gly 820 825 830 Gly Lys Gly Asp Lys Ala Phe Pro Ala Thr Asn Pro Leu Arg Lys Pro 835 840 845 Asp Lys Glu Gly Asn Pro Thr Gly Pro Ile Val Arg Thr Val Thr Lys 850 855 860 Val Ile Asp Lys Leu Ser Gly Ile Pro Val Arg Gly Gly Ile Ala Lys 865 870 875 880 Asn Asp Thr Met Leu Arg Val Asp Val Phe Thr Lys Ala Gly Arg Phe 885 895 Page 3770 of 3790 890 Pro Pro Glu Lys Arg Arg Gly Leu Ala 1010 1015 1342 600 PRT uncultured bacterium] 1342 Glu Gly Leu Asp Ile Asp Arg Val Leu Asn Asp Ala Asn Tyr Ala Gin Gin Ala Leu Arg Glu Asp Leu Gin Arg Leu Gly Thr Tyr Ser Glu Gin 325 330 335 Page 3772 of 3790 Asp Leu Leu Gly Val Arg Thr Leu Phe Val Ser Arg Ala Pro Gin Arg 340 345 350 Arg Asn Asp Gly Ala Val His Lys Glu Thr Ile Tyr Ala Gin Pro Glu 355 360 365 Ala Leu Arg Lys Gin Gly Gly Val Val Gin Lys Val Pro Leu Thr Ser 370 375 380 Leu Ser Leu Lys Asp Leu Asp Asn Leu Ala Asp Pro His Arg Asn Ala 385 390 395 400 Lys Leu Tyr Thr Ala Leu Arg Ala Arg Leu Glu Ala His Gly Gly Lys 405 410 415 Ala Asp Lys Ala Phe Gly Pro Asp Gin Pro Phe Tyr Lys Pro Asp Lys 420 425 430 Asn Gly Asn Pro Thr Gly Pro Ile Val Arg Thr Ile Lys Leu Val Ile 435 440 445 Asp Lys Leu Ser Gly Ile Pro Ile Arg Gly Gly Val Ala Lys Asn Asp 450 455 460 Thr Met Leu Arg Val Asp Val Phe Thr Lys Ala Gly Lys Phe His Leu 465 470 475 480 Val Pro Val Tyr Val His His Arg Val Thr Gly Leu Pro Asp Arg Ala 485 490 495 Ile Val Ala Phe Lys Asp Glu Val Glu Trp Thr Gin Val Asp Asp Ser 500 505 510 Phe Lys Phe Leu Phe Ser Ile His Pro Asn Asp Leu Ile Arg Ile Gly 515 520 525 Leu Lys Ala Lys Glu Pro Met Ile Gly Tyr Phe Ala Ser Cys His Arg 530 535 540 Gly Thr Gly Ala Phe Asn Val Trp Ser His Asp Arg Asn Thr Ser Val 545 550 555 560 Gly Lys Ser Gly Ser Val Glu Gly Ile Gly Ile Lys Thr Ala Leu Ser 565 570 575 Leu Glu Lys Leu Asn Ile Asp Val Leu Gly Asn Val Tyr Pro Ala Arg 580 585 590 Page 3773 of 3790 Pro Glu Gin Arg His Gly Leu Ala 595 600 1343 1011 PRT uncultured delta 1343 Page 3774 of 3790 Met Ala Arg Lys Leu Val Phe Glu Glu Ala Leu Gin Ile Leu Ala Phe 210 215 220 Gin Arg Lys Gin Gly His Glu Leu Ser Lys Asp Phe Glu Lys Thr Tyr 225 230 235 240 Leu Asp Val Leu Met Gly Gin Arg Ser Gly Arg Ser Pro Lys Leu Gly 245 250 255 Asn Cys Ser Leu Ile Pro Ser Glu Leu Arg Ala Pro Ser Ser Ala Pro 260 265 270 Ser Thr Glu Trp Phe Lys Phe Leu Gin Asn Leu Gly Asn Leu Gin Ile 275 280 285 Ser Asn Ala Tyr Arg Glu Glu Trp Ser Ile Asp Ala Pro Arg Arg Ala 290 295 300 Gin Ile Ile Asp Ala Cys Ser Gin Arg Ser Thr Ser Ser Tyr Trp Gin 305 310 315 320 Ile Arg Arg Asp Phe Gin Ile Pro Asp Glu Tyr Arg Phe Asn Leu Val 325 330 335 Asn Tyr Glu Arg Arg Asp Pro Asp Val Asp Leu Gin Glu Tyr Leu Gin 340 345 350 Gin Gin Glu Arg Lys Thr Leu Ala Asn Phe Arg Asn Trp Lys Gin Leu 355 360 365 Glu Lys Ile Ile Gly Thr Gly His Pro Ile Gin Thr Leu Asp Glu Ala 370 375 380 Ala Arg Leu Ile Thr Leu Ile Lys Asp Asp Glu Lys Leu Ser Asp Gin 385 390 395 400 Leu Ala Asp Leu Leu Pro Glu Ala Ser Asp Lys Ala Ile Thr Gin Leu 405 410 415 Cys Glu Leu Asp Phe Thr Thr Ala Ala Lys Ile Ser Leu Glu Ala Met 420 425 430 Tyr Arg Ile Leu Pro His Met Asn Gin Gly Met Gly Phe Phe Asp Ala 435 440 445 Cys Gin Gin Glu Ser Leu Pro Glu Ile Gly Val Pro Pro Ala Gly Asp 450 455 460 Page 3775 of 3790 Arg Val Pro Pro Phe Asp Glu Met Tyr Asn Pro Val Val Asn Arg Val 465 470 475 480 Leu Ser Gin Ser Arg Lys Leu Ile Asn Ala Val Ile Asp Glu Tyr Gly 485 490 495 Met Pro Ala Lys Ile Arg Val Glu Leu Ala Arg Asp Leu Gly Lys Gly 500 505 510 Arg Glu Leu Arg Glu Arg Ile Lys Leu Asp Gin Leu Asp Lys Ser Lys 515 520 525 Gin Asn Asp Gin Arg Ala Glu Asp Phe Arg Ala Glu Phe Gin Gin Ala 530 535 540 Pro Arg Gly Asp Gin Ser Leu Arg Tyr Arg Leu Trp Lys Glu Gin Asn 545 550 555 560 Cys Thr Cys Pro Tyr Ser Gly Arg Met Ile Pro Val Asn Ser Val Leu 565 570 575 Ser Glu Asp Thr Gin Ile Asp His Ile Leu Pro Ile Ser Gin Ser Phe 580 585 590 Asp Asn Ser Leu Ser Asn Lys Val Leu Cys Phe Thr Glu Glu Asn Ala 595 600 605 Gin Lys Ser Asn Arg Thr Pro Phe Glu Tyr Leu Asp Ala Ala Asp Phe 610 615 620 Gin Arg Leu Glu Ala Ile Ser Gly Asn Trp Pro Glu Ala Lys Arg Asn 625 630 635 640 Lys Leu Leu His Lys Ser Phe Gly Lys Val Ala Glu Glu Trp Lys Ser 645 650 655 Arg Ala Leu Asn Asp Thr Arg Tyr Leu Thr Ser Ala Leu Ala Asp His 660 665 670 Leu Arg His His Leu Pro Asp Ser Lys Ile Gin Thr Val Asn Gly Arg 675 680 685 Ile Thr Gly Tyr Leu Arg Lys Gin Trp Gly Leu Glu Lys Asp Arg Asp 690 695 700 Lys His Thr His His Ala Val Asp Ala Ile Val Val Ala Cys Thr Thr Page 3777 of 3790 Ile Arg Gly Tyr Tyr Arg Thr Phe Asn Ile Ala Asn Gly Gin Leu Lys 965 970 975 Ile Ser Thr Tyr Leu Glu Gly Arg Gin Asp Phe Asp Phe Phe Gly Ala 980 985 990 Asn Arg Leu Ala His Phe Ala Lys Val Gin Val Asn Leu Leu Gly Lys 995 1000 1005 Val Ile Lys 1010 Pro Gin Glu Tyr Thr Leu Gly Leu Asp Leu Gly Ile Lys Ser Ile Gly 20 25 30 Trp Ala Ile Leu Ser Gly Glu Arg Ile Ala Asn Ala Gly Val Tyr Leu 35 40 45 Phe Glu Thr Ala Glu Glu Leu Asn Ser Thr Gly Asn Lys Leu Ile Ser 50 55 60 Lys Ala Ala Glu Arg Gly Arg Lys Arg Arg Ile Arg Arg Met Leu Asp 65 70 75 80 Arg Lys Ala Arg Arg Gly Arg His Ile Arg Tyr Leu Leu Glu Arg Glu 85 90 95 Gly Leu Pro Thr Asp Glu Leu Glu Glu Val Val Val His Gin Ser Asn 100 105 110 Arg Thr Leu Trp Asp Val Arg Ala Glu Ala Val Glu Arg Lys Leu Thr 115 120 125 Lys Gin Glu Leu Ala Ala Val Leu Phe His Leu Val Arg His Arg Gly 130 135 140 Tyr Phe Pro Asn Thr Lys Lys Leu Pro Pro Asp Asp Glu Ser Asp Ser 145 150 155 160 Page 3778 of 3790 Ala Asp Glu Glu Gin Gly Lys Ile Asn Arg Ala Thr Ser Arg Leu Arg 165 170 175 Glu Glu Leu Lys Ala Ser Asp Cys Lys Thr Ile Gly Gin Phe Leu Ala 180 185 190 Gin Asn Arg Asp Arg Gin Arg Asn Arg Glu Gly Asp Tyr Ser Asn Leu 195 200 205 Met Ala Arg Lys Leu Val Phe Glu Glu Ala Leu Gin Ile Leu Ala Phe 210 215 220 Gin Arg Lys Gin Gly His Glu Leu Ser Lys Asp Phe Glu Lys Thr Tyr 225 230 235 240 Leu Asp Val Leu Met Gly Gin Arg Ser Gly Arg Ser Pro Lys Leu Gly 245 250 255 Asn Cys Ser Leu Ile Pro Ser Glu Leu Arg Ala Pro Ser Ser Ala Pro 260 265 270 Ser Thr Glu Trp Phe Lys Phe Leu Gin Asn Leu Gly Asn Leu Gin Ile 275 280 285 Ser Asn Ala Tyr Arg Glu Glu Trp Ser Ile Asp Ala Pro Arg Arg Ala 290 295 300 Gin Ile Ile Asp Ala Cys Ser Gin Arg Ser Thr Ser Ser Tyr Trp Gin 305 310 315 320 Ile Arg Arg Asp Phe Gin Ile Pro Asp Glu Tyr Arg Phe Asn Leu Val 325 330 335 Asn Tyr Glu Arg Arg Asp Pro Asp Val Asp Leu Gin Glu Tyr Leu Gin 340 345 350 Gin Gin Glu Arg Lys Thr Leu Ala Asn Phe Arg Asn Trp Lys Gin Leu 355 360 365 Glu Lys Ile Ile Gly Thr Gly His Pro Ile Gin Thr Leu Asp Glu Ala 370 375 380 Ala Arg Leu Ile Thr Leu Ile Lys Asp Asp Glu Lys Leu Ser Asp Gin 385 390 395 400 Leu Ala Asp Leu Leu Pro Glu Ala Ser Asp Lys Ala Ile Thr Gin Leu 405 410 415 Page 3779 of 3790 Cys Glu Leu Asp Phe Thr Thr Ala Ala Lys Ile Ser Leu Glu Ala Met 420 425 430 Tyr Arg Ile Leu Pro His Met Asn Gin Gly Met Gly Phe Phe Asp Ala 435 440 445 Cys Gin Gin Glu Ser Leu Pro Glu Ile Gly Val Pro Pro Ala Gly Asp 450 455 460 Arg Val Pro Pro Phe Asp Glu Met Tyr Asn Pro Val Val Asn Arg Val 465 470 475 480 Leu Ser Gin Ser Arg Lys Leu Ile Asn Ala Val Ile Asp Glu Tyr Gly 485 490 495 Met Pro Ala Lys Ile Arg Val Glu Leu Ala Arg Asp Leu Gly Lys Gly 500 505 510 Arg Glu Leu Arg Glu Arg Ile Lys Leu Asp Gin Leu Asp Lys Ser Lys 515 520 525 Gin Asn Asp Gin Arg Ala Glu Asp Phe Arg Ala Glu Phe Gin Gin Ala 530 535 540 Pro Arg Gly Asp Gin Ser Leu Arg Tyr Arg Leu Trp Lys Glu Gin Asn 545 550 555 560 Cys Thr Cys Pro Tyr Ser Gly Arg Met Ile Pro Val Asn Ser Val Leu 565 570 575 Ser Glu Asp Thr Gin Ile Asp His Ile Leu Pro Ile Ser Gin Ser Phe 580 585 590 Asp Asn Ser Leu Ser Asn Lys Val Leu Cys Phe Thr Glu Glu Asn Ala 595 600 605 Gin Lys Ser Asn Arg Thr Pro Phe Glu Tyr Leu Asp Ala Ala Asp Phe 610 615 620 Gin Arg Leu Glu Ala Ile Ser Gly Asn Trp Pro Glu Ala Lys Arg Asn 625 630 635 640 Lys Leu Leu His Lys Ser Phe Gly Lys Val Ala Glu Glu Trp Lys Ser 645 650 655 Arg Ala Leu Asn Asp Thr Arg Tyr Leu Thr Ser Ala Leu Ala Asp His 660 665 670 Page 3780 of 3790 Leu Arg His His Leu Pro Asp Ser Lys Ile Gin Thr Val Asn Gly Arg 675 680 685 Ile Thr Gly Tyr Leu Arg Lys Gin Trp Gly Leu Glu Lys Asp Arg Asp 690 695 700 Lys His Thr His His Ala Val Asp Ala Ile Val Val Ala Cys Thr Thr 705 710 715 720 Pro Ala Ile Val Gin Gin Val Thr Leu Tyr His Gin Asp Ile Arg Arg 725 730 735 Tyr Lys Lys Leu Gly Glu Lys Arg Pro Thr Pro Trp Pro Glu Thr Phe 740 745 750 Arg Gin Asp Val Leu Asp Val Glu Glu Glu Ile Phe Ile Thr Arg Gin 755 760 765 Pro Lys Lys Val Ser Gly Gly Ile Gin Thr Lys Asp Thr Leu Arg Lys 770 775 780 His Arg Ser Lys Pro Asp Arg Gin Arg Val Ala Leu Thr Lys Val Lys 785 790 795 800 Leu Ala Asp Leu Glu Arg Leu Val Glu Lys Asp Ala Ser Asn Arg Asn 805 810 815 Leu Tyr Glu His Leu Lys Gin Cys Leu Glu Glu Ser Gly Asp Gin Pro 820 825 830 Thr Lys Ala Phe Lys Ala Pro Phe Tyr Met Pro Ser Gly Pro Glu Ala 835 840 845 Lys Gin Arg Pro Ile Leu Ser Lys Val Thr Leu Leu Arg Glu Lys Pro 850 855 860 Glu Pro Pro Lys Gin Leu Thr Glu Leu Ser Gly Gly Arg Arg Tyr Asp 865 870 875 880 Ser Met Ala Gin Gly Arg Leu Asp Ile Tyr Arg Tyr Lys Pro Gly Gly 885 890 895 Lys Arg Lys Asp Glu Tyr Arg Val Val Leu Gin Arg Met Ile Asp Leu 900 905 910 Met Arg Gly Glu Glu Asn Val His Val Phe Gin Lys Gly Val Pro Tyr Page 3781 of 3790 Asn Arg Leu Ala His Phe Ala Lys Val Gin Val Asn Leu Leu Gly Lys 995 1000 1005 Val Ile Lys 1010 1345 1120 PRT Veillonella sp. 1345 Thr Asp Lys Gly Thr Asn Tyr Val Lys Tyr Thr Lys Gin Gly Val Asn Page 3782 of 3790 115 120 125 Gly Asn Thr Ser Ala Thr Gin Glu Glu Phe Tyr Lys Tyr Val Arg Lys 130 135 140 Val Val Ser Val Leu Pro Glu Thr Glu His Thr Arg Arg Ile Val Gin 145 150 155 160 Lys Leu Glu Glu Gly Thr Phe Leu Pro Leu Gin Arg Ile Ser Lys Asn 165 170 175 Gly Val Val Pro Tyr Gin Leu His Lys Glu Glu Leu Val Arg Ile Leu 180 185 190 Asp Lys Ala Thr Val Asn Phe Pro Phe Leu Asn Lys Val Glu Asn Gly 195 200 205 Leu Thr Val Ala Asp Lys Ile Ile Ser Ile Leu Glu Phe Lys Ile Pro 210 215 220 Tyr Tyr Val Gly Pro Leu Asn Pro Thr His Ser Ile Glu Asn Gly Gly 225 230 235 240 Phe Ala Trp Val Val Arg Lys Glu Ala Gly Gin Val Leu Pro Trp Asn 245 250 255 Phe Glu Gin Lys Val Asp Val Gin Ala Ser Ala Val Lys Phe Ile Glu 260 265 270 Asn Leu Thr Asn Lys Cys Thr Tyr Leu Ile Asp Gin Asp Val Leu Pro 275 280 285 Lys Tyr Ser Leu Leu Tyr Ala Glu Phe Ser Leu Leu Asn Glu Leu Asn 290 295 300 Asn Ile Arg Val Asn Asp Lys Pro Leu Pro Ala Asp Val Lys Gin Ala 305 310 315 320 Phe Ile Arg Asp His Phe Ile Ser Leu Gin Asp Ser Lys Thr Ala Thr 325 330 335 Lys Lys Val Val Ala Lys Tyr Leu Val Asp Asn Asn Tyr Val Ser Gin 340 345 350 Pro Pro Ile Ile Thr Gly Met Asp Gin Gin Ile Ala Thr Lys Leu Thr 355 360 365 Page 3783 of 3790 Ser His Arg Asp Met Thr Arg Ile Leu Gly Glu His Phe Asp His Ala 370 375 380 Met Ala Glu Asp Ile Ile Arg Tyr Ile Thr Ile Phe Gly Glu Ser Lys 385 390 395 400 Asp Met Leu Arg Gin Val Leu Lys Asn Tyr Tyr Gly Asp Arg Leu Thr 405 410 415 Thr Glu Gin Ile Lys Lys Leu Gly Lys Leu Thr Tyr Thr Gly Trp Gly 420 425 430 Arg Leu Ser Lys Lys Phe Leu Ser Asp Ile Trp Gly Met Lys Lys Asn 435 440 445 Asp Asp Asp Ala Glu Ala Gly Thr Ile Ile Glu His Met Arg Glu Gly 450 455 460 Gin Glu Asn Leu Met Gin Leu Leu Ser Ser Ser Tyr Ser Phe Ile Asp 465 470 475 480 Val Val Gin Glu Tyr Val Thr Asn Val Leu Gly Glu Lys Glu Lys Thr 485 490 495 Ala Phe Glu Met Leu Glu Asp Leu Ser Leu Ser Pro Met Val Lys Arg 500 505 510 Ser Val Trp Gin Thr Leu Arg Ile Leu Asp Glu Ile Val Ser Ile Arg 515 520 525 Lys Glu Leu Pro Lys Lys Ile Phe Val Glu Val Ala Arg Thr Asn Lys 530 535 540 Ala Asp Lys Lys Arg Thr Gin Ser Arg Lys Ala Leu Leu Glu Glu Leu 545 550 555 560 Tyr Lys Gin Ile Lys Asp Glu Asp Val His Val Leu Gin Gin Glu Leu 565 570 575 Glu Ser Lys Glu Asp Ser Ala Leu Asn Ser Lys Lys Leu Tyr Leu Tyr 580 585 590 Phe Thr Gin Met Gly Arg Cys Met Tyr Ser Gly Arg Arg Ile Asp Ile 595 600 605 His Glu Leu Phe Thr Asp Lys Tyr Asp Ile Asp His Ile Tyr Pro Arg 610 615 620 Page 3784 of 3790 Ser Leu Thr Lys Asp Asp Ser Trp His Asn Ile Val Leu Val Glu Lys 625 630 635 640 Gin Leu Asn Ala Glu Lys Thr Asp Arg Phe Pro Ile Leu Ser Ala Ile 645 650 655 Gin Ser Lys Gin Lys Gly Phe Trp Lys Leu Leu Trp Asp Arg Gly Phe 660 665 670 Ile Ser Glu Lys Lys Tyr Asp Arg Leu Val Arg Thr Thr Asp Leu Thr 675 680 685 Asp Glu Glu Leu Asn Gin Phe Ile Asn Arg Gin Met Val Ser Thr Asn 690 695 700 Gin Ser Val Lys Ala Val Thr Thr Leu Leu His Gin Leu Tyr Pro Glu 705 710 715 720 Thr Glu Val Val Phe Ser Lys Ala Glu Asn Val Ser Asp Phe Arg His 725 730 735 Asp Tyr Asp Phe Val Lys Val Arg Ser Ile Asn His His His His Ala 740 745 750 Lys Asp Ala Tyr Leu Asn Ile Val Val Gly Asn Val Tyr His Glu Lys 755 760 765 Phe Thr Lys Asn Phe Leu Ser Phe Ala Lys Gin Lys Gly Thr Arg Arg 770 775 780 Thr Tyr Asn Leu Thr Lys Ile Phe Glu Tyr Glu Ile Lys Leu Thr Glu 785 790 795 800 Glu Ser Lys Lys Val Ile Trp Asp Pro Asn Ile His Met Asp Ile Val 805 810 815 Lys Lys Met Met Lys Ser Asn Asp Val Arg Val Thr Gin Arg Ala Val 820 825 830 Pro Gin Lys Gly Gly Leu Ser Asp Glu Thr Ile Tyr Lys Lys Gly Ile 835 840 845 Ala Lys Arg Gly Val Tyr Leu Pro Leu Lys Ser Ser Asp Glu Arg Val 850 855 860 Arg Asp Val Glu Lys Tyr Gly Gly Arg Thr Ser Ile Thr Ile Ser Glu 865 870 875 880 Page 3785 of 3790 Glu Gin Glu Ile Lys Ile Lys Page 3786 of 3790 1115 1120 1346 983 PRT Verminephrobacter aporrectodeae 1346 Met Arg Arg Arg Arg Asp Arg Leu 1 5 Leu Lys Arg Lys Ala Arg Met His 10 15 Asp Gin Leu Met Arg His Gly Phe 20 Phe Pro Ala Asp Ala Ala Gly Arg 25 30 Lys Val Leu Glu Arg Leu Asn Pro 35 40 Tyr Gin Leu Arg Ala Lys Gly Leu 45 His Gin Ala Leu Thr Pro Gly Glu 50 55 Phe Ala Arg Ala Leu Phe His Ile 60 Asn Gin Arg Arg Gly Phe Gin Ser 65 70 Asn Arg Lys Thr Asp Arg Lys Asp 75 80 Asn Glu Ser Gly Ala Leu Lys Gin 85 Ala Ile Ser Glu Leu Arg Ala Gin 90 95 Ile His Asp Ser Gly Cys Ala Thr 100 Val Gly Glu Trp Phe Trp Lys Glu 105 110 Arg Met Gin Gin Lys Pro Glu Gly 115 120 Val His Arg Gin Gly Val Arg Ala 125 Arg Tyr Arg Glu Thr Pro Tyr Thr 130 135 Thr Asp Glu Gly Arg Gin Arg Ile 140 Asp Lys Arg Tyr Asp Leu Tyr Val 145 150 Asp Arg Ala Met Ile Glu Gin Glu 155 160 Phe Asp Ala Leu Trp Ala Val Gin 165 Ala Ala Leu Gin Pro Gly Leu Phe 170 175 Thr Asp Ala Ala Cys Lys Glu Leu 180 Arg Tyr Thr Leu Leu Phe Gin Arg 185 190 Lys Leu Arg Pro Val Lys Pro Gly 195 200 Arg Cys Thr Leu Leu Pro Glu Glu 205 Glu Arg Ala Pro Leu Ala Leu Pro Ser Thr Gin Arg Phe Arg Ile Leu Page 3788 of 3790 Gly Leu Asn Gin Val Arg Thr Val Val Asn Ala Leu Ile Arg Arg Tyr 465 470 475 480 Gly Arg Pro Ser Glu Val Val Val Glu Leu Ala Arg Asp Leu Lys Gin 485 490 495 Ser Arg Glu Gin Gin Gin Glu Thr Gin Arg Lys Gin Ala Glu Asn Gin 500 505 510 Arg Arg Asn Thr Arg Ile Arg Glu Arg Ile Ala Glu Thr Leu Gly Ile 515 520 525 Ser Pro Glu Arg Val Arg Ser Ser Asp Ile Gin Lys Trp Ile Leu Trp 530 535 540 Glu Glu Leu Ser Phe Asp Val Val Asp Arg Arg Cys Pro Tyr Ser Gly 545 550 555 560 Glu Gin Ile Ser Thr Thr Met Leu Leu Ser Pro Lys Val Glu Ile Glu 565 570 575 His Ile Leu Pro Phe Ser Gin Thr Leu Asp Asp Ser Leu Asn Asn Arg 580 585 590 Thr Val Ala Leu Arg Glu Ala Asn Arg Ile Lys Arg Asn Arg Thr Pro 595 600 605 Trp Asp Ala Arg Ala Asp Phe Glu Ala Arg Gly Trp Ser Tyr Glu Gly 610 615 620 Ile Leu His Arg Ala Glu Arg Met Pro Leu Arg Lys Arg Tyr Arg Phe 625 630 635 640 Ala Pro Asp Gly Tyr Gin Arg Trp Leu Gly Glu Asp Lys Asp Phe Leu 645 650 655 Ala Arg Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg Val Ala Ala Asn 660 665 670 Tyr Leu Arg Leu Val Cys Pro Lys Pro Gin Gly Val Arg Val Ile Pro 675 680 685 Gly Arg Met Thr Ala Met Leu Arg Ala Lys Phe Gly Leu Asn Asp Val 690 695 700 Leu Gly Leu Asp Gly Glu Lys Asn Arg Asn Asp His Arg His His Ala 705 710 715 720 Page 3789 of 3790 Val Asp Ala Cys Val Ile Gly Val Thr Asp Gin Gly Leu Met Gin Arg 725 730 735 Phe Ala Arg Ala Ser Ala Gin Ala Arg Glu Asp Gly Leu Thr Arg Leu 740 745 750 Val Gin Asp Met Pro Leu Pro Trp Pro Ser Tyr Arg Asp His Val Glu 755 760 765 Arg Ala Val Arg His Ile Trp Val Ser His Lys Pro Asp His Gly Phe 770 775 780 Glu Gly Ala Met Met Glu Glu Thr Ala Tyr Gly Ile Arg Lys Asp Gly 785 790 795 800 Ser Ile Lys Pro Arg Arg Lys Ala Asp Gly Ser Ala Gly Arg Glu Val 805 810 815 Val Asn Leu Ile Arg Ile Thr Glu Ser Arg Gin Pro Val Arg His Gly 820 825 830 Val Asp Ser Gin Gly Gin Pro Leu Pro Tyr Lys Gly Tyr Val Gly Gly 835 840 845 Ser Asn Tyr Cys Ile Glu Ile Thr Ala Asn Asp Gin Gly Lys Trp Glu 850 855 860 Gly Ala Val Ile Ser Thr Phe Glu Ala Tyr Arg Ile Val Arg Ala Ser 865 870 875 880 Gly Trp Gly Arg Leu Arg His Cys Ser His Gly Gin Asn Gly Arg Pro 885 890 895 Leu Met Met Arg Leu Met Ile Gly Asp Ala Val Arg Leu Ala Leu Asp 900 905 910 Gly Ser Glu Lys Thr Met Arg Val Val Lys Ile Ser Ala Asn Gly Gin 915 920 925 Val Phe Leu Val Ala Pro Asn Glu Ala Asn Val Asp Ala Arg Asn Arg 930 935 940 Asp Lys Ala Asp Pro Phe Ala Tyr Val Ser Lys Lys Ala Gly Ser Phe 945 950 955 960 Gin Ser Ala Lys Ala Arg Gin Val Ser Ile Ser Pro Ile Gly Glu Leu 965 970 975 Page 3790 of 3790 Arg Asp Pro Gly Phe Lys Gly 980