Nebuliser

[0001] The present invention relates to a nebulizer according to the preamble of claim 1.

[0002] The starting point for the present invention is the nebulizer sold under the name "Respimat" in the form of an inhaler, as shown in its basic design in WO 91/14468 A1 and in the specific embodiment in WO 97/12687 A1 (Figures 6a, 6b ), and in Figs. 1 and 2 in the accompanying drawings. The nebulizer has as a fluid container to be sprayed, a slide-in rigid container having an inner bag containing the fluid and a pressure generator with a drive spring for supplying and spraying the fluid.

[0003] To complement the disclosure of the present application, reference is made to the full disclosure of WO 91/14468 A1 and WO 97/12687 A1. In general, this disclosure preferably relates to a nebulizer with a spring pressure of 5 to 200 MPa, preferably 10 to 100 MPa per fluid, with a volume of fluid delivered during one stroke of 10 to 50 ml, preferably 10 to 20 ml, most preferably about 15 ml . The fluid is transformed into aerosol droplets that have an aerodynamic diameter of up to 20 mm, preferably from 3 to 10 mm. In addition, the disclosure contained herein preferably relates to a cylindrical nebulizer of about 9 cm to about 15 cm, and about 2 cm to about 5 cm wide and with a spray angle of 20 ° to 160 °, preferably 80 ° to 100 °. These values ​​also apply to the nebulizer as disclosed in the present invention as particularly preferred values.

[0004] Before use, the nebulizer is opened for the first time, it is opened by unscrewing the bottom of the housing and the sealed container is placed in the nebulizer. The container is opened by a delivery tube, which is inserted inside the bag when the container is placed in it. Then the lower part of the housing is pressed again.

[0005] By turning the lower part of the nebulizer housing, the drive spring can be stretched and the fluid can be sucked into the compression chamber of the pressure generator. When it is compressed, the container is moved to the bottom of the housing, in one motion in the nebulizer, and when stretched for the first time, it is pierced through its base by means of a piercing element in the bottom of the housing to allow air to flow from or into it. After manual operation of the fluid blocking element in the pressure chamber, it is pressurized by a drive spring and is supplied through the nozzle to the mouthpiece in the form of an aerosol, without the use of propellant.

[0006] Once opened, the empty nebulizer container can be replaced with a full one and the nebulizer can then be reused.

[0007] US 6 412 659 B1 discloses a container seated in an outer cap containing pumping means for discharging the contents of the container. The container is shaped as a small bottle containing a bottle neck having a spray pump disposed thereon. The container placed in the neck a tightly fitting insert that is closed in its initial state. During the first use, the pump housing part is screwed or moved forward towards the axis of the container and the bottom part of the insert is open.

[0008] US 2001/0007327 A1 relates to a dispenser for unloading or storing particulate carriers. The known dispenser comprises a sealed container, a plunger pump and a piercing element. During the first use of the dispenser, the lower part of the housing is pushed telescopically into the upper part of the housing, so that the piercing element pierces the container closure and ensures a permanent fluid connection with the container.

[0009] US 5,547,131 relates to a pen-shaped dispensing device having a liquid dispensing container and a protective cap. The device contains a drive system connected to the container. The piston inside the container is moved by the drive unit according to the dose selection. When the device is not in use, the protective cap is attached to the housing. Intermediate connecting elements are provided between the cap and the housing to hold the cap in place.

[0010] US 6,626,379 B1 discloses a dispenser containing a dry substance that is held outside the fluid container in the dispenser. The dispenser has a container for a liquid, said container being provided with a closing plug which can be pierced. During start-up, the liquid flow passes into the storage chamber and mixes with the dry medium and exits through the open outlet.

[0011] US 5,584,417 relates to a dispenser that consists of two telescopic housing parts. The lower part holds at least one container with the substance to be unloaded. Telescopic movement compresses the substance through the sliding piston and pumps the liquid through the open outlet.

[0012] US 5,503,302 discloses a dispenser for receiving, puncturing and dispensing fluid from a sealed container. The nebulizer contains a bottom case with an open area. The open area is adapted to receive and loosely hold the pierced top of an airtight container.

[0013] DE 27 54 100 A1 relates to a device for storing two products separately and dispensing them in a droplet manner.

[0014] US 3,802,604 discloses an apparatus for storing two products separately and dispensing them simultaneously. The device contains a container with a neck, a covered flange cap sealed in the neck with its collar lying on the edge of the neck. Above the attachment the trocar is placed in line with the attachment. Detachable strap detachable to hold the trocar from the attachment.

[0015] The object of the present is to provide a nebulizer that is easier to use and has greater operational reliability.

[0016] The object is achieved by a nebulizer according to claim 1. Advantageous further features are subject to the dependent claims.

[0017] The basic idea of ​​the present invention is that even in the delivered condition the nebulizer comprises a sealed container contained therein and the nebulizer is constructed such that the container is open inside the nebulizer before or during the first use of the nebulizer. This basic idea is hereinafter abbreviated as "pre-installed container". This makes operation easier because there is no need to open the nebulizer, insert the container and close the nebulizer. Furthermore, undesirable soiling or damage to the nebulizer caused by incorrect handling during insertion of the container can thus be excluded. Accordingly, there is a better safety of use because it is not possible for the container to be inserted incorrectly or otherwise incorrectly used during insertion.

[0018] Another aspect is the construction of the nebulizer such that the container is not replaceable and in particular cannot be removed. This excludes container replacement. This, in turn, leads to easier operation and thus an improvement in operational reliability. It also prevents the nebulizer from being used or reused in an undesirable or unauthorized manner.

[0019] In particular, the nebulizer cannot be opened and the bottom part of the housing cannot be removed in order to replace the empty container with a full one in an undesirable way.

[0020] The combination of the pre-installed container and the structure that makes the container non-removable causes in particular easy operation and high operational safety, since the user can only use the nebulizer as a disposable item as long as the container is not empty and unwanted or unauthorized further use from the nebulizer is prevented by the fact that the container cannot be replaced.

[0021] However, suitably easy operation and greater operational reliability for the user can also be achieved when the container is pre-installed in the pharmacy, for example, by trained personnel and possibly open at the same time, provided that the container is not - removable, in particular the nebulizer cannot be opened by the user.

[0022] Further advantages, properties, features and aspects of the present invention will become apparent from the claims and the following description of some preferred embodiments with reference to the drawings, in which:

Fig. 1 is a non-schematic cross section through a known nebulizer in an unpowered state;

Fig. 2 is a schematic cross section, rotated 90 ° compared to Fig. 1, by a known nebulizer in a tensioned state;

Fig. 3 is a schematic cross-sectional view through the proposed nebulizer according to the first embodiment, in a condition as delivered with a sealed container therein;

Fig. 4 is a schematic cross-sectional view of the nebulizer according to Fig. 3 in an active state or with an open container;

Fig. 5 is a schematic cross-sectional view through the proposed nebulizer according to the second embodiment in the delivered condition with a sealed container therein;

Fig. 6 is an enlarged detail of Fig. 5 along the dotted line;

Fig. 7 is a schematic cross-sectional view through the nebulizer of Fig. 5 in an active state or with an open container;

Fig. 8 is a schematic cross-sectional view through the proposed nebulizer according to the third embodiment in the delivered condition with a sealed container therein;

Fig. 9 is an enlarged detail of Fig. 8 on the broken line;

Fig. 10 is a schematic cross-sectional view through the nebulizer of Fig. 8 in the active or open state of the container and with the actuation element pressed into it;

Fig. 11 shows the nebulizer according to Fig. 10 without an actuator;

Fig. 12 is a schematic perspective view of a proposed nebulizer according to a fourth embodiment having an actuator similar to the third embodiment but not pressed;

Fig. 13 is a schematic cross-sectional view through the proposed nebulizer according to the fifth embodiment in the condition delivered with the sealed container therein;

Fig. 14 is a schematic cross-sectional view through the nebulizer of Fig. 13 in an active state or with an open container;

Fig. 15 is a schematic cross-sectional view through the proposed nebulizer according to the sixth embodiment in the delivered condition with a sealed container therein;

Fig. 16 is a schematic cross-sectional view through the nebulizer of Fig. 15 in an active state or with an open container;

Fig. 17 is a schematic cross-sectional view through the proposed nebulizer according to the seventh embodiment, as supplied, with a sealed container;

Fig. 18 is a schematic cross-sectional view through the nebulizer of Fig. 17 in an active state or with an open container;

Fig. 19 is a schematic cross-sectional view through the proposed nebulizer according to the eighth embodiment, in the condition supplied with the sealed container contained therein;

Fig. 20 is a schematic cross-sectional view through the nebulizer of Fig. 19 in an active but unstretched state or with an open container;

Fig. 21 is a view of the nebulizer corresponding to Fig. 20, but in a tensioned state;

Fig. 22 is a detail in Fig. 21 taken along the dotted line, enlarged;

Fig. 23 is a schematic cross-sectional view through the proposed nebulizer according to the ninth embodiment, in the condition supplied with the sealed container contained therein;

Fig. 24 is a schematic cross-section through the nebulizer of Fig. 23 in an active but unstretched state or with an open container;

Fig. 25 is a view of the nebulizer corresponding to Fig. 24, but in a tensioned state;

Fig. 26 is a detailed perspective view of the transport lock for the container in the nebulizer according to the ninth embodiment in a secured condition;

Fig. 27 is a side view, partly in section, of the transport lock of Fig. 26 in a secured state;

Fig. 28 is a view of the transport lock corresponding to Fig. 27 in an open state;

Fig. 29 is a schematic axial view of the transport lock in the open state;

Fig. 30 is a perspective view of the inner part of the nebulizer according to the ninth embodiment;

Fig. 31 is a schematic view of a portion of the nebulizer housing according to the ninth embodiment;

Fig. 32 is a side view, partly in section, of a transport lock for the nebulizer according to the tenth embodiment, in a secured state;

Fig. 33 is a view of the transport lock corresponding to Fig. 32, in the open state;

Fig. 34 is a schematic cross-sectional view through the bottom portion of the proposed nebulizer according to the eleventh embodiment in an intermediate state;

Fig. 35 is a schematic axial cross-section through the nebulizer of Fig. 34 in the overlapping area of ​​the housing parts with the inner portion in the delivered condition;

Fig. 36 is a schematic axial section through the nebulizer of Fig. 34, corresponding to Fig. 35, in an intermediate state;

Fig. 37 is a side view, partly in section, of a housing part with a container and a transport lock for the nebulizer according to Fig. 34;

Fig. 38 is a side view, partly in section, of a part of the nebulizer housing according to

Fig. 34 with the inner part partially depressed;

Fig. 39 is a side view, partly in section, of a part of the nebulizer housing according to

Fig. 34, with the inner part fully depressed;

Fig. 40 is a side view, partly in section, of a part of the nebulizer housing of Fig. 34 with the container open or punctured at the base;

Fig. 41 is a schematic cross-sectional view through the proposed nebulizer according to the twelfth embodiment, in the condition delivered with the sealed container contained therein; and

Fig. 42 is a schematic cross-sectional view through the nebulizer of Fig. 41 in the active state in a stretched or open container.

[0023] In the figures, the same reference numbers have been used for identical or similar elements, resulting in corresponding or comparable properties and benefits, even when the associated description is not repeated.

[0024] Figs. 1 and 2 show a known nebulizer 1 for spraying a fluid 2, in particular a highly effective pharmaceutical composition and the like, schematically shown in the unstressed state (Fig. 1) and in the stressed state (Fig. 2). The nebulizer 1 is designed in particular as a portable inhaler, and preferably works without a propellant.

[0025] When a fluid 2, preferably a liquid, more particularly a pharmaceutical composition, is sprayed, an aerosol is formed which can be inhaled or inhaled by the user (not shown). Typically, inhalation is performed at least once a day, more especially several times a day, preferably at set intervals depending on the patient's condition.

[0026] The known nebulizer 1 has an insertable and preferably replaceable container 3 containing fluid 2. The container thus forms a fluid reservoir 2 to be nebulized. Preferably, the container 3 contains an amount of fluid 2 or active substance that is sufficient to provide 200 dosage units, e.g., to allow 200 sprays or applications. A typical container 3 as disclosed in WO 96/06011 A1 has a volume of about 2 to 10 ml.

[0027] The container 3 is substantially cylindrical or cassette-shaped and when the nebulizer 1 is opened the container can be placed in it from below and changed as needed. It is preferably rigid and the fluid 2 in particular is kept in a foldable bag 4 in a container 3.

[0028] The nebulizer 1 also includes a pressure generator 5 for transferring and nebulizing the fluid 2, in particular for pre-setting and optionally adjusting the dosage amount. The pressure generator 5 has a handle 6 for the container 3, associated drive spring 7, only partially shown, with a locking element 8 that can be manually operated to release it, a transport tube 9 with a check valve 10, a pressure chamber 11 and a blow-off nozzle 12 in mouthpiece area 13. The container 3 is fixed in the nebulizer 1 via the handle 6 so that the transport tube 9 penetrates into the container 3. The handle 6 can be made in such a way that the container 3 can be replaced.

[0029] When the drive spring 7 is axially tensioned, the handle 6 with the container 3, and the transport tube 9 are moved downwards in the drawings and the fluid 2 is sucked from the container into the pressure chamber 11 of the pressure generator 5 through the check valve 10.

[0030] In a further relaxation after actuation of the blocking element 8, the fluid 2 in the pressure chamber 11 is compressed when the transport tube 9 with the presently closed check valve 10 is moved upwards by loosening the drive spring 7, and now acts as a press. This pressure moves the fluid 2 through the blow-off nozzle 12, after which it is atomized in the aerosol 14, as shown in Fig. 1. The particle droplet size for the Respimat device has already been discussed above.

[0031] The user (not shown) can inhale the aerosol 14, while the air supply can be sucked into the mouthpiece 13, through at least one air supply opening 15. [0032] The nebulizer 1 comprises an upper housing part 16 and an internal part 17, which can rotate relative to it (Fig. 2), having an upper part 17a and a lower part 17b (Fig. 1), while in particular the manually operated housing part 18 is detachably attached, particularly fitting onto the inner portion 17, preferably by means of a securing element 19. For insertion and / or replacement of the container 3, the housing part 18 can be detached from the nebulizer 1.

[0033] The housing portion 18 can be rotated relative to the upper housing portion 16, moving with it the portion 17b of the inner portion 17, which is lower in the drawings. As a result, the drive spring 7 is biased in the axial direction by a drive mechanism (not shown) acting on the handle 6. During tensioning, the container 3 is moved in an axial downward direction until the container 3 takes its final position, as shown in Fig. 2. In this state, the drive spring 7 is live. During the nebulization process, the container 3 moves back to its initial position through the drive spring 7. Thus, the container 3 makes a lifting motion during the tensioning and atomization process.

[0034] The housing portion 18 preferably forms a cap-like lower housing portion and is mounted on or above the lower free end portion of the container 3. As the drive spring 7 is under tension, the container 3 moves with its end part (hereinafter) to the housing part 18 or to its end face, while the spring 20 acting in the axial direction located in the housing part 18 rests on the base 21 of the container and pierces the container 3 or its primary sealing with a piercing element 22 when the container contacts it for the first time to let in air.

[0035] The nebulizer 1 comprises a control device 23 that counts the actuations of the nebulizer 1, preferably by detecting rotation of the inner part 17 relative to the upper part 16 of the housing.

[0036] The structure and operation of the twelve embodiments of the proposed nebulizer 1 will now be described in more detail, referring to Figs. 3 to 42, but highlighting only significant differences from the nebulizer 1 according to Figs. 1 and 2. Notes on

Figures 1 and 2 are therefore used respectively or in an additional range, while all desirable combinations of the features of the nebulizer 1 according to Figures 1 and 2, and the nebulizer according to the embodiments described below, or in conjunction with each other are possible.

[0037] Figs. 3 and 4 show in schematic cross-sectional views the first embodiment of the proposed nebulizer 1. Fig. 3 shows the condition delivered with the sealed container 3. Fig. 4 shows the active state, i.e. after the container 3 has been opened.

[0038] As proposed, the (still) closed container 3 is already mounted in the nebulizer 1 in the delivered condition as shown in Fig. 3. In the closed condition, in the illustrated embodiments, the outer seal 24 on the end upper part of the container 3 and the septum 25, membrane, plastic seal or the like placed inside the container 3 (only partially shown in the drawings) has not yet been opened. In addition, in the closed state, in the embodiments shown, the vent 26 in the base of the container 3, which can be opened by the piercing element 22, is sealed, i.e. not yet pierced. It should be noted that the container 3 may also have fewer and / or different opening possibilities depending on the particular construction.

[0039] In all proposed embodiments, the nebulizer 1 is constructed such that the container 3 is or can be opened inside the nebulizer 1, before or during the first use of the nebulizer 1. The container 3 has already been opened, in particular when the seal 24 and the septum 25 or the like were opened. This is also referred to hereinafter as the active state. The piercing or opening of the vent 26 can be carried out separately and especially later when the nebulizer 1 is tensioned (for the first time).

[0040] It is proposed that the opening of the container 3 is carried out in particular by means of a delivery element, in particular a transport tube 9 or the like, preferably by piercing the container 3 or introducing it into the container 3. In a relative relative movement, especially in the longitudinal direction or the lifting direction of the container 3 with respect to the transport tube 9, the transport tube 9 pierces the seal 24 and is introduced through the partition 25 into the container 3, in particular into the bag 4, the container 3 being open that is, a fluid connection is created so that the liquid 2 comes out of the container 3. The container 3 is thus, in particular open at the end end.

[0041] During normal tensioning and spraying, the container 3 is then preferably displaced together with the conveyor element or transport tube 9 by means of a handle 6, the fluid connection being produced being maintained and the container preferably therefore is always open.

[0042] Venting provided, preferably at the base, as mentioned above, by opening the vent 26 may be carried out before or during or after the above-mentioned opening of the container 3, in particular at the end end, depending on the specific embodiment or requirements.

[0043] In the first embodiment, the container 3 is factory-installed and the housing part 18 in the delivered condition has not been fully pressed in axially. Rather, the securing element 27 is mounted between the housing portion 18 and the upper housing portion 16, so that the housing portion and bottom portion 18 are pressed far enough away from the upper housing portion 16 to be able to maintain (still) a sealed container 3 axially from the transport tube 9.

[0044] In this inactive remote position, the housing part 18 is preferably secured by means of at least one locking arm 28 located in the upper housing part 16 or inner part 17, so that it cannot be lost, and in particular cannot be released. Preferably, the locking arm 28 engages with the locking projection 29 in the securing recess 30 in the housing portion 18, and thus secures the housing portions 18 to completely remove the axial blocked engagement. However, other design solutions are also possible.

In this remote inactive position, the housing part 18 is preferably secured by means of at least one locking arm 28 located in the upper housing part 16 or from the inside 17, so that it cannot be lost and in particular cannot be released . Preferably, the locking arm 28 engages with the locking projection 29 in the safety recess 30 in the housing portion 18, and thus secures the housing portion 18 against complete axial removal through the locking connection. However, other design solutions are also possible.

[0045] In particular, the housing part and bottom 18 of the nebulizer 1 cannot be detached from the nebulizer 1 after it has been (partly) pushed axially for the first time, i.e. the nebulizer 1 cannot be opened any longer, and therefore the container 3 cannot be changed, i.e. it cannot be deleted again.

[0046] In the first embodiment, the securing element 27 is at least substantially cylindrical hollow and is disposed axially between the housing portion 18 and the upper housing portion 16. To activate the nebulizer 1, i.e. press the housing portion 18 fully in the axial direction and thus open the container 3, the security element 27 must first be removed. In the first embodiment, the security element 27 is constructed in a manner such as a band or the like, made of plastics, for example, it can be manually opened, removed or damaged. The security element 27 may alternatively or simultaneously form or provide a seal source. However, other embodiments of the security element 27 are also possible, for example in the form of a security tag or the like.

[0047] Once the safety element 27 has been removed, the user (not shown) can press the housing part 18 fully in the axial direction and thereby bring the active nebulizer 1 into active state, i.e. open the container 3 by inserting the conveyor element or transport tube 9. Fig Fig. 4 shows this active state with the housing part 18 fully pushed up. In this pushed state, the housing portion 18 is preferably attached or held by a locking connection, particularly by joining the locking arm 28 or locking projection 29 into a suitable other safety recess 31 or by another mechanical safety device.

[0048] Fig. 4 shows the nebulizer 1 or container 3, in the active state, the container 3 is open and the housing part 18 has been completely pushed in the axial direction. In order to bring the handle 6 into contact with the container 3 at the front end and then be able to move the container 3 over it for tensioning and pressing strokes, it may be necessary to tension the nebulizer 1 for the first time. During this tensioning process, the handle 6 is moved along with the transport tube 9 in an axial direction to the housing part 18, thereby reducing the handle 6 to be connected to the container 3 and preferably also pressing the container 3 in relation to the piercing element 22, in the region from the base of the part casing 18, and thus for piercing or opening the vent 26. Fig. 4 shows the nebulizer 1 at rest, i.e. after the first atomization, in particular. The handle 6 is connected to the container 3 and the transport tube 9 is completely inserted into the container 3.

[0049] In the delivered condition shown in Fig. 3, i.e. with the container 3 (still) closed, the nebulizer 1 can be put away for storage. In particular, the closed seal 24 ensures that no solvent contained in the fluid 2 can leak or in any case only leak in trace amounts.

[0050] To prevent unwanted opening of the container 3, in particular seal 24 or vent 26, in the delivered condition of nebulizer 1, the nebulizer 1 has a transport lock that is not shown in the first embodiment. By means of the locking connection, the transport lock prevents the undesired axial movement of the container 3 in the nebulizer 1, for example during transport, in the event of accidental dropping of the nebulizer 1, or the like, and thus accidental release. Some of the possible ways of securing it in transport are described in more detail with respect to other embodiments.

[0051] It should be noted that the opening of the container 3 is preferably carried out solely by mechanical and / or manual actuation. However, it can additionally or alternatively be opened by other means, for example chemically, electrically, magnetically, pneumatically, hydraulically or similar means.

[0052] The proposed nebulizer 1 is active after removal of the securing element 27 and the (complete) axial push in the housing part 18 and can be used in the same way as the nebulizer 1 shown in Figures 1 and 2. As the earlier nebulizer was to be opened by removing the housing part 18, placing it in the container 3 and then closing the nebulizer1 by pushing the housing part 18, the process is now simpler to perform and more reliable in operation. In particular, it prevents the user from placing the wrong container 3 or used containers 3 in the nebulizer 1. In addition, it ensures that the separately delivered container 3 is not accidentally opened before being placed in the nebulizer 1. Furthermore, the proposed solution prevents possible soiling or damage of the nebulizer 1, e.g. a transport tube 9 or the like when the nebulizer 1 is opened and the container 3 is used in a manner wrong.

[0053] Preferably, the container 3 cannot then be removed, especially because the nebulizer 1 cannot be opened and the housing part 18 cannot be removed again, undesirably replacing the container 3 by the user, in particular unwanted periodic or subsequent opening of the nebulizer 1 by the user can be prevented.

[0054] Other embodiments will now be described in more detail with reference to Figures 5 to 35. The corresponding explanations are limited to the principal differences with respect to the first embodiment referred to above and the known nebulizer 1 according to Figures 1 and 2 . The comments and explanations given with respect to the first embodiment and the known nebulizer 1 therefore refer respectively or in a complementary manner, even if they have not been repeated, for simplicity.

[0055] Figs. 5 to 7 show a second embodiment of the proposed nebulizer 1. Fig. 5 shows the nebulizer 1 in the delivered condition, ie a container 3 inserted therein, but still sealed. Fig. 6 shows an enlarged detail of Fig. 5. Fig. 7 shows the nebulizer 1 in the active state, i.e. with the container 3 open.

[0056] In a second embodiment, the nebulizer 1, preferably the housing element 18 has a telescopic structure and can be slid together or axially shortened. In particular, the housing part 18, according to the second embodiment, consists of two axially inserted telescopic parts 32 and 33, and axially to the insertable base part 34.

[0057] Fig. 5 shows the nebulizer 1 or housing part 18 in a telescopically inactive state. In this state, the 2 telescopic parts 32, 33 and the base part 34 are preferably secured against undesirable axial insertion by means of snap joints and / or friction protection. In particular, the forces required or to be overcome for axial insertion are matched so that when axial pressure is applied to the base part 34, first the first telescopic part 32 is pushed into the housing part 18, then the second telescopic part 33 is pushed into the first telescopic part 32 and finally the base part 34 is pushed axially into the second telescopic part 33.

[0058] Fig. 7 shows axial pushing in the active state. Telescopic parts in this condition

32, 33 and the base portion 34 are preferably axially secured in their axial positions by a snap connection, friction protection and in particular, interconnection.

[0059] For example, for axially securing the telescopic parts 32 and 33 relative to the housing part 18, the respective locking protrusions 29 combine with the securing recesses 30 and 31 to obtain the desired securing in the axially elongated position on one side and in the axially retracted position On the other hand.

[0060] The enlargement of the detail of Fig. 5 shown in Fig. 6 shows the transport lock 36 to the nebulizer 1 for axial securing and securing the container 3 in the delivered condition of the nebulizer 1. In the embodiment shown, the transport lock 36 has a surrounding protective bead or at least one arm security 37. The securing bead or securing arm 37 cooperates with the radially slightly widened base of the container 21 such that the container 3 in the delivered condition is securely held in a defined axial direction on the annular arm or annular flange 38 or other contact.

[0061] In the delivered condition, the base part 34 in the illustrated embodiment is telescopically attached or in an axially extended position by at least one radial projection or surrounding bead 35, which connects radially behind complementary structures of telescopic part 33. These safety forces can only be overcome by applying sufficiently strong axial pressure, for example as a result of plastic deformation or elastic and / or radial deformation of the protrusions / beads 35. During the subsequent axial pushing of the base part 34 relative to the telescopic part 33 the piercing element 22 preferably located on the base part 34, pierces the vent hole 26 and opens it. In addition, the base portion 34 contacts the base of the container 21 and directs the container 3 axially out of the transport lock 36 and presses it against the container head on or to the handle 6 of the nebulizer 1 (from nebulizer 1 under voltage). Thus, the axial force holding transport lock 36 is a safety bead or the safety arm 37 is constructed to be sufficiently elastic or plastically deformable in a radial direction for this purpose.

[0062] After the base part 34 is completely inserted into the second telescopic part 33, the base part 34 is preferably again secured against axial displacement or outward movement by a radial connection and / or a frictional connection with the telescopic part 33.

[0063] Figs. 8 to 11 show a third embodiment of the proposed nebulizer 1.

Fig. 8 shows the nebulizer 1 as supplied with the sealed container 3. Fig. 9 shows an enlarged partial view of Fig. 8. Fig. 10 shows the nebulizer 1 in the active state, i.e. with the container open 3. Fig. 11 shows the nebulizer 1 in the active state, as in Fig. 10, but without the actuator 39.

[0064] In a second embodiment, the nebulizer 1 further includes, in the housing portion 18, an actuator 39, which is preferably in the form of a cap, cauldron or bowl. The actuator 39 is only partially embedded or pushed into the housing portion 18 in the delivered condition and holds the container 3 axially at a distance from the transport tube 9 in the nebulizer 1, as shown in Fig. 8. The housing portion 18 is suitably constructed to be open at its base.

[0065] Optionally, the guide sleeve 40 for radial guiding of the container 3 is arranged in the opening area of ​​the base in the housing part 18. The guide sleeve 40 extends axially beyond the end of the housing part 18, in particular in the delivered condition and can be pressed axially into the housing part 18 in actuation by depressing actuator 18 (completely) in the axial direction. Depending on the construction of the housing part 18, in particular depending on the degree of radial clearance of the container 3, the guide sleeve 40 may also be omitted.

[0066] The base part 34, by means of the piercing element 22, as in the second embodiment, and the insertion part 41 are preferably mounted in the actuating element 39.

[0067] The insertion part 41 is constructed in a similar manner to the second telescopic part 33 according to the second embodiment. As can be seen from the enlarged detail shown in Fig. 9, the base part 34 and the insert element 41 connect radially one after the other, as already explained in relation to the second embodiment, in the relationship between the second telescopic part 33 and the base part 34, and therefore a reference to attention is made at this point.

[0068] The insert element 41 also forms a transport lock 36, as already described in connection with the second embodiment, and therefore reference is made to the explanations given therein. [0069] In the delivered condition, the base part 34 is held axially by preferably radial connection and / or friction locking by the actuating element 39. The base part 39 in turn holds the insert element 41 in the axial direction, and this in turn axially secures the container 3 through the transport lock. 36.

[0070] To activate the actuator 39, it is fully depressed in the base portion 18 in the axial direction until the actuator 39 receives or closes the nebulizer 1 and especially the housing part 18, preferably in a cap or hat-like manner as shown in Fig. 10.

[0071] During axial pushing of the actuator 39, the container 3 is first placed on the transport tube 9, i.e. it is opened by the transport tube 9.

[0072] Further pushing of the actuating element 39 onto the housing part 18 causes the insert element 41 to engage with the housing part 18 and in particular the locking arms 28 with the locking projections 29 connecting the corresponding securing recesses 31 in the housing part 18 and thereby secure the element inserts 41 axially to housing part 18. [0073] During the last part of the axial movement, the base part 34 is finally pressed axially against the insertion part 41, as a result of which the piercing element 22 pierces or opens the vent opening 26 and the base part 34 axially releasing the container 3 from transport lock 36, and - from the nebulizer 1 or a live pressure generator 5 - presses it in the axial direction or in the handle 6 to bring it into contact with the container 3. This position is shown in Fig. 10.

[0074] In the fully depressed state, as shown in Fig. 10, the nebulizer 1 can be applied by means of an actuating member 39. In particular, the nebulizer 1 or its pressure generator 5 can be tensioned in the usual way by rotating the actuator 39 respectively .

[0075] However, the actuator 39 is not needed for (further) use of the nebulizer 1. Instead, depending on the design of the nebulizer 1, the actuator 39 may or must be removed after activation (fully retracted) and in particular must be removed axially. Preferably, the nebulizer 1 is constructed in such a way that axial detachment or removal of the actuator 39 is only possible after having been pushed fully into the housing part 18 or after the nebulizer 1 has been actuated. A suitable closing or releasing mechanism may be provided for this purpose, but not shown here.

[0076] Fig. 12 is an exploded schematic view of the fourth embodiment of the proposed nebulizer 1. In this alternative embodiment, as in the third embodiment, the actuator 39 can be used to attach the nebulizer 1 and for this purpose preferably has a spring-like clamp holding or holding clamp 42 or the like outside. The actuator 39 and hence the nebulizer 1 can, if desired, be attached to a belt, waistband, pocket and the like by means of a retaining bar and clamp 42. [0077] As in the third embodiment, the actuator 39 can be removed from the nebulizer 1, if necessary - when nebulizer 1 has been started or container 3 is open. In particular, the actuator 39 according to the third embodiment can be used if desired to secure the nebulizer 1 as desired. For optimum protection of the nebulizer 1, the actuator 39 is preferably releasably connected to the nebulizer 1 by clamping and / or snapping, and in particular the nebulizer 1 can be located in, preferably, at least substantially substantially hollow cylindrical portion of the actuator 39.

[0078] The construction and use of the actuating element 39 as a holder for the nebulizer 1 can also be designed independently of the previously inserted container 3, i.e. in general for each type of nebulizer 1. Other designs are therefore possible, in particular; for example, the actuator 39 can only be attached to the nebulizer 1.

[0079] Figs. 13 and 14 are schematic cross-sectional views showing the fifth embodiment of the proposed nebulizer 1. Fig. 13 shows the nebulizer 1 in its delivered condition (with the sealed container 3 in place). Fig. 14 shows the nebulizer 1 in the active state, i.e. with the container 3 open.

[0080] The fifth embodiment is substantially similar to the third embodiment. The nebulizer 1 can be activated by pressing on the actuator 39, which is preferably in the form of a cap, cauldron or cup. Only the fundamental differences between this and the third embodiment will be described below.

[0081] The insert element 41 is not provided with a locking arm 28, and for mounting on the housing part 18 is preferably in the shape of a hat, cauldron, bowl or cap. In the active state, the insert element 41 is located around or through the annular portion 43, which is formed in the free end region of the housing portion 18, in particular surrounds and forms a through hole for axial insertion of the container 3. In particular, the insert element 41 is connected to the housing portion 18 in the axial direction in a frictional or co-locking connection in the active state.

[0082] Preferably, the insert element 41, in the third embodiment, forms the smoothest possible outer contour in the active state and when connected to the housing part 18 in such a way as to give the nebulizer 1 a pleasant surface feel and ease of use even with the actuating element 39 being deleted. According to the third embodiment, the actuating element 39 in the fifth embodiment can in fact be completely removed or also axially detached after actuation.

[0083] In the fifth embodiment, the nebulizer 1 may include a guide sleeve 40 according to the third embodiment, for radial centering and for fixing or supporting the container 3 in the delivered condition, in particular to prevent unwanted detachment from the transport lock 36 by tilting the container 3 to the side. However, the guide sleeve 40 is not in the embodiment shown. Instead, the through hole for the container 3 is formed at the free axial end of the housing part 18 and is provided with a slight radial clearance relative to the container 3, for example in the region of the annular part 43, so that there is no need for a separate component such as a sleeve leader 40.

[0084] Another structural difference between the third embodiment and the fifth embodiment is that in the fifth embodiment, the base part 34 is axially held by the actuator 39, alternatively or additionally to radial clamping as provided, as shown in Fig. 13 . Preferably for this purpose, the actuator 39 connects axially to a preferred nip, clip or screw protrusion 44 in a corresponding recess in the base of the base part 34 so that the bottom part 34 is axially attached to the actuator 39.

[0085] In the active state, the actuator 39 may be released from the base portion 34 to allow the actuator 39 to be removed in the axial direction if necessary. Preferably, the co-blocking or frictional connection and material forces are designed in such a way that the base part 34 is held by the insert element 41 in the pressed or retracted piercing position shown in Fig. 14, even when the actuator 39 is pulled out in the axial direction. For example, when the actuation member 39 is extended in the axial direction, the projection 44 is broken and remains on or in the base portion 34.

[0086] The design of the transport lock 36 and the release of the container 3 from the transport lock 36 during actuation preferably correspond to the third embodiment. Preferably, the actuation takes place even with the nebulizer 1 or the pressure of the generator 5 under voltage, so that when the actuator 39 is fully inserted in the axial direction, the container 3 is not only open and pierced at the base by inserting the transport tube 9, but is also connected to end of the head with the handle 6. [0087] Figs. 15 and 16 are schematic cross-sections through a sixth embodiment of the proposed nebulizer 1. Fig. 15 shows nebulizer 1 in the delivered position. Fig. 16 shows the nebulizer 1 in the active position, i.e. ready for use with the container 3 open.

[0088] In the sixth embodiment, in a similar manner to that described in the third embodiment, the insert element 41 and the base part 34 are provided which can be put into operation in the corresponding axially open part of the housing 18. Unlike the third embodiment, a separate or additional actuator 39 is needed. Instead, the insert element 41 is made in the form of a sleeve and is guided and held by a hollow cylindrical portion 45 that is formed, in particular cast on housing parts 18, especially in the delivered condition and during axial insertion into nebulizer 1 or housing parts 18. In the depressed or active state, the portion of the insert 41 together with the base portion 34 terminates the hollow cylindrical portion 45, thereby forming at least a substantially smooth outer contour for the nebulizer 1.

[0089] In the sixth embodiment, the base part 34 is held by the insert element 41, preferably in a certain manner by radial coupling in an axial position in which the piercing element 22 is in the axial direction at a distance from the base seal, i.e. the vent 26 in container 3.

[0090] To activate it, pressure is applied to the base portion 34. As a result, the base portion 34 is axially inserted and pushed (further) into the portion of the insert 41, as a result of which the piercing element 22 pierces or opens the vent 26. At the same time, sooner or later, the insert element 41 with the container 3 substantially inserted therein slides into the nebulizer 1 or part of the housing 18, and as a result the transport tube 9 is axially inserted into this container 3 and the container 3 is thus open. With the nebulizer 1 or pressure generator 5 under pressure, the container 3 is finally brought into contact with the handle 6 at the front end. In the depressed active position shown in Fig. 16, the insert element 41 and the base part 34 are preferably mounted in an axially latching and / or clamping manner on the housing part 18 or the hollow cylindrical part 45.

[0091] To prevent undesired retraction of the insert element 41 during insertion, for example with a semi-inserted or fully inserted position, the nebulizer 1 according to the sixth embodiment preferably comprises a progressive, preferably saw toothed snap element 46 or the like between the housing part 18 and the insert element 41 so that the insert element 41 is introduced only axially but cannot be axially retracted in the opposite direction. In the embodiment shown, the latch member 46 is formed outwardly longitudinally over the sleeve portion of the insert members 41. Then, at least one locking arm 28 located on the nebulizer 1, in particular on the housing portion 18 in the hollow cylindrical portion 45 engages the latch member 46 Figs. 15 and 16 show two axially extending latch arms 29 that are resiliently biased in a radial direction to the insert element 41.

[0092] To form the transport lock, to prevent accidental pressing of the insert element 41 in the delivered condition of the nebulizer 1, according to the sixth embodiment of the fastening element 27 is preferably in the form or has a security label as shown in Fig. 15. For example, the security label is placed or placed radially outward between the at least one latching arm 28 and the wall of the hollow cylindrical portion 45 to lock at least one locking arm 28 or several or all of the locking arms 28 against axial jumping outward, and thereby preventing axial displacement within the insert element 41. Only after removal, especially the axial retraction of the safety tag, the locking arms or latch locking arm 28, and therefore also the latch member 46 are released and the insert element 41 can be pushed axially and the nebulizer 1 is thus activated.

[0093] Figs. 17 and 18 show schematic cross-sections through a seventh embodiment of the proposed nebulizer 1. Fig. 17 shows the nebulizer 1 in the delivered condition. Fig. 18 shows the active nebulizer 1.

[0094] The seventh embodiment is very similar to the sixth embodiment. However, in the sixth embodiment no insert element 41 is provided. Instead, in the delivered condition, the housing part 18 is pressed axially only partially on the nebulizer 1, especially in the inner part 17 and the abutment part 47 provided on it. The locking part 47 is located, for example, in the bottom part 17b of the inner part 17. The locking portion 47 is extended axially beyond the end of the inner portion 17 to allow the housing portion 18 to be held sufficiently displaced in the delivered condition so that the container 3 pre-installed in the housing portion 18 is still axially spaced from the transport tube 9. Preferably, by means of a suitable latching or the like coupling, the housing part 18 cannot be retracted in the axial direction or removed after it has been axially (partly) pressed onto the locking part 47.

[0095] The housing part 18 in the seventh embodiment has a base part 34, in a manner corresponding to or similar to the manner in which the insert element 41 holds the base part 34 in the sixth embodiment. For activation, with nebulizer 1 or pressure generator 5, preferably in a tensioned state, the base 34 is axially depressed again. As a result, the housing portion 18 is pushed (fully) onto the nebulizer 1 or the inner portion 17 in the axial direction. The container 3 is opened by axially inserting the transport tube 9. Axial pressing of the base part 34 into the housing part 18 - in particular until the base part 34 is flush with the axial end of the housing part 18 - this results in piercing the container base 3, releasing the container 3 from axial transport lock 36 at the base, which is formed by a part of the housing 18, in the seventh embodiment and axially inserting the container 3 into the handle 6.

[0096] Preferably, between the housing portion 18 and the nebulizer 1 or internal portion 17, there is a device (not shown) such as the latch member 46 in the sixth embodiment having at least one associated locking arm 28 or the like only to allow the housing parts 18 to be pushed towards the nebulizer 1, but prevent axial retraction or movement in the opposite direction. According to a sixth embodiment, the security element 27 (not shown) in the mold or containing the security label or the like can also be provided to prevent the housing parts 18 from being pressed in as delivered if the security element 27 has not been removed.

[0097] Figs. 19 to 22 are schematic cross-sections through an eighth embodiment of the proposed nebulizer 1. Fig. 19 shows the nebulizer 1 in its as-delivered condition. Fig. 20 shows the nebulizer 1 in the active state, i.e. with the container 3 already open, but with the nebulizer 1 or pressure generator 5 not yet tensioned. Fig. 21 shows the nebulizer 1 in its active and tensed state. Fig. 22 shows, in enlarged detail, the part of Fig. 21 and shows transport lock 36 in the eighth embodiment.

[0098] In the eighth embodiment, in a similar manner to the seventh embodiment, the housing portion 18 is pushed axially only partially in the delivered condition.

Unlike the seventh embodiment, the housing portion 18, in the eighth embodiment, is closed at the base, i.e. no separate basic portion 34 is provided. Instead, the piercing element 22 is on the inside of the base of the housing portion 18 and in the delivered condition the container 3 is kept in the axial position. A gap with a properly constructed transport lock 36 prevents the opening or punching of the vent 26 in the bottom.

[0099] In the example shown, the transport lock 36 is preferably held in an axially movable manner in or through a portion of the housing 18, which allows the container base 3 to be pierced upon activation.

[0100] In the embodiment shown, the transport lock 36 comprises at least one gripper arm 48, and preferably a plurality of gripper arms 48, prior to axially holding the container 3 as supplied, engaging around its preferably radially expanded base end as shown in Fig. 19 on one gripper arm 48.

[0101] As in the seventh embodiment, the eighth embodiment preferably comprises a device such as a locking element 46 having at least one associated locking arm 28, between the housing part 18 and the nebulizer 1 or the internal part 17 to allow the housing parts 18 to be pressed axially only but not an axial return. The locking element 46 is preferably formed on the inner portion of the housing 18 as shown in Figs. 19 to 21. The locking arm 28 with the locking projection 29 engages in the locking element 46. In contrast to the sixth example, a thicker locking element 46 is provided here. In addition, it is also possible to block axially the pressing movement through the locking latch arm 28 by means of the safety element 27 (not shown), in particular in the mold or containing security labels or the like.

[0102] In the eighth embodiment, activation is preferably carried out in the unsecured state of the nebulizer 1. After removing the protective label or the like, which is optionally positioned, the housing part 18 is pressed against the nebulizer 1 especially the inner part 17. At the same time the transport tube 9 is placed axially in the container 3 and the container 3 is thus opened.

[0103] In the fully inserted state, the container 3 is pressed axially further or deeper into the housing part 18 so that the piercing element 22 pierces or opens the vent 26 and the transport lock 36 is released.

[0104] The transport lock 36 is open in particular with at least one axial arm or projection 49 which is formed on the inner part 17 or preferably the locking part 47. In the embodiment shown, a plurality of axial arms 49 corresponding to the gripper arms 48 which rotate and they bias the gripper arms 48 while the housing part 18 is pushed fully and thus opens the transport lock 36 as shown in Fig. twenty and 21, especially in Fig. 22.

[0105] Opening the transport lock 36 or gripper arms 48 preferably requires force such that first of all the transport lock 36 is moved axially towards the base of the housing part 18, and as a result the base of the container 3 is open. This is achieved by suitably matched force factors between the axial attachment of the transport lock 36 in or on the housing portion 18 and the necessary opening force for rotation of the gripper arms 48. Only after reaching the axial end position of the transport lock 36, in the housing portion 18, the gripper arms 18 and thus the transport lock 36 are opened to release the container 3 in the axial direction.

[0106] During the next first tensioning, the transport tube 9 is moved further into the container 3 and the handle 6 is brought into engagement with the container 3. Fig. 21 shows this position. During the subsequent release of the nebulizer 1, the container can be moved axially from the handle 6 in a known manner in a nebulization process when the transport lock 36 remains open and releases the container 3 for axial movement.

[0107] Figs. 23 to 31 show the ninth embodiment of the proposed nebulizer 1. Fig. 23 shows the nebulizer 1 in the delivered condition. Fig. 24 shows the nebulizer 1 in an activated but not yet tensioned state. Fig. 25 shows the nebulizer 1 in active and tensioned condition. FIG. 26 is a detailed perspective view of a transport lock 36 with a securing element mounted on the container 3 such as a cartridge element 50 and a base element 51 molded or mounted on the housing portion 18. Fig. 27 shows a side view of the cartridge element 50 in a position in which it is axially lifted from the base element 51, which is shown partly in section, for clarity. Fig. 28 is a view corresponding to Fig. 27 cartridge element 50 in a lowered condition. Fig. 29 is a schematic axial view with the transport lock 36 in the open state. Fig. 30 is a perspective view of the inner portion 17 of the nebulizer 1. Fig. 31 shows a part of the housing 18 in a schematic perspective view.

[0108] The ninth embodiment is substantially similar to the eighth embodiment in structure and design. The following description will list only the most important differences. The comments on the eighth embodiment and other embodiments also, in particular, complement each other.

[0109] In a ninth embodiment, the housing portion 18 has not been fully inserted in the delivery condition. The transport lock 36 secures the container 3 to the base of the housing portion 18 in the delivered condition.

[0110] In a ninth embodiment, axial displacement is preferably transformed upon activation into a rotational motion to open the transport lock 36 or axially release the container 3. In particular, the release or release is carried out on an oblique plane. The detachment movements of the axial pusher and the release of the transport lock 36 by rotational movement allow the axial fastening of the container 3 in the mounted state to be optimal and the relatively easy opening of the transport lock 36 to release the container 3 axially. This is explained below with reference to the embodiment shown.

[0111] The cartridge element 50 is connected to rotate the container 3, particularly formed, forged or injection molded thereon, and surrounds the periphery or edge of the radially expanded base of the container 21. In the delivered condition as shown in Fig. 23, 26 and 27, the cartridge element 50 with the container 3 is axially and non-rotationally attached to the base element 51, and more precisely at an axial distance from the base element 51, so that the piercing element 22 in the basic element 51 does not open or pierces the base of the container 3.

[0112] The rigid gripper arms 48 are mounted, in particular formed on the base element 51, the arms 48 engaging over the radial projections 52 of the insert elements 50 in a particular rotational position and thereby securing the insert element 50 before moving in the axial direction with away from base element 51. Locking arms 53 on base element 51 block radial stops 54 of cartridge element 50 and thereby prevent rotation of cartridge element 50 (clockwise in the embodiment shown). Rotation in the opposite direction is blocked by a suitable construction of gripping arms 48 and / or cooperation with sliding slopes 55 on the element 50 and slopes 56 on the element 51.

[0113] The sliding slopes 55 and the ramps 56 extend circumferentially and are inclined in the circumferential direction and matched so that the cartridge element 50 in (locked) a specific rotational position is kept axially spaced or raised with the base element 51 in the delivered condition, as can be seen in particular in Fig. 27.

[0114] To activate the nebulizer 1 and open the container 3, the housing portion 18 is fully pushed in the axial direction. The inner portion 17 includes axial arms or projections 49 shown in Fig. 30, which, in the active state or when the housing part 18 is fully depressed, deflect the locking arms 53 and thereby open the transport lock 36 or at least retract or unlock it. The locking arms 53 or the sections of the locking arms 53 blocking the radial abutments 54 are deflected radially outwards and thus allow the insert element 50 to be rotated relative to the base element 51.

[0115] Figs. 24, 25, 28 and 29 show the cartridge element 51 already rotated to the right. The rotation takes place by sliding the sliding slope 55 over the ramps 56, in particular when tensioning the pressure generator 5 or pressing the container 3 by means of the handle 6. During this sliding movement, the element of the insert 50 is moved axially with respect to the element 51 and the container base 3 is pierced by piercing element 22 on base element 51. In addition, axial rotation releases the cartridge element 50 from the container 3 when the radial projections 52 are moved under the gripper arms 48 and thus axially released. The rotation of the cartridge element 50 for possible punching of the container 3 and axial release thereof is preferably from about 5 to 10 ° C.

[0116] Of course, the transport lock 36 may also have a different structure, but with a comparable function; in particular, it should allow opening or at least reversing or releasing of the transport lock 36 by rotating the insert element 50 relative to the base element 51 counterclockwise.

[0117] The principle has been described above, or the specific design of the transport lock 36 according to the ninth embodiment may also be used in other embodiments, in particular in the eighth embodiment, if desired.

[0118] The base element 51 preferably has safety arms 57 that engage in respective pouches 58 in the housing part 18 for attachment to said housing parts 18. In particular, during assembly, the base element 51 is attached to the housing part 18, preferably together with container 3 and element 50. This allows for easy installation. However, the base element 51 can be attached to the housing portion 18 in another way and / or can be formed in this way.

[0119] In the embodiment shown, the inner part 17 has several, in particular three, locking arms 28 circumferentially. The housing portion 18 shown, for example, in Fig. 31, however, preferably has only one latching member 46, on the inner side, on which, respectively, only one associated locking arm 28 engages with the locking projection 29. The function of this coupling has already been discussed with reference to the sixth and eighth embodiments, in particular, there is therefore no need to discuss it again here.

[0120] Other locking arms 28 engage in securing recesses 30 and 31 on the housing portion 18, recesses 30 correspond to the axial position in the delivered condition and recesses 31 correspond axially to the fully inserted position of the housing portion 18. In this way, particularly stable fastenings of the housing parts 18 in both positions are obtained, in order to exclude the possibility for the user to disconnect the housing parts 18 from the nebulizer 1 or for the partial removal of the housing parts 18 not to be allowed in a completely depressed position.

[0121] In a ninth embodiment, the housing portion 18 is preferably mounted in a non-rotatable manner on the nebulizer 1 or the inner portion 17, as in other embodiments.

[0122] In the ninth embodiment, activation is preferably carried out with an unstretched nebulizer 1 or pressure generator 5. Accordingly, after activation by axially inserting the housing part 18, the first tensioning is still required to bring the handle 6 into contact with the container 3 as shown in Fig. 25.

[0123] However, the nebulizer 1 or pressure generator 5 may already be tensioned as supplied. This is the case for the first, second, third, fifth, sixth and seventh embodiment.

[0124] According to a particularly preferred alternative embodiment, the cartridge element 50 and the reservoir 3 are inseparably connected to each other. Preferably, the cartridge element 50 is for coding the container 3 or the fluid 2 or the drug contained therein. Coding may vary depending on the particular active substance and / or dosage. The coding by the cartridge element 50 ensures that the container 3 with the cartridge element 50 can only be used in conjunction with a specific nebulizer 1, in particular only with a specific or matched housing part 18 or base element 51. In this way, it can be ensured that only the right container 3 or the right fluid 2 is used with the appropriate nebulizer 1. [0125] Coding is in particular an appropriate adaptation or complementary structure of the protrusions, depressions, undercuts, placement and number of arms or the like to ensure that the container 3 with a given element of the cartridge 50 can only be inserted nebulizer 1 if the coding matches, i.e. if the parts match.

[0126] With respect to the cartridge element 50, it should generally also be indicated, in connection with the ninth embodiment, which need not necessarily be a continuous circumferential structure. Instead, it can also, if desired, extend only over part of the container circumference 3, in particular along the container base 21. However, instead of the cartridge element 50, the container 3 may also be provided with, or may form, another security or similar element (not shown) which interacts in particular only mechanically with the base element 51, e.g. by means of a correspondingly corresponding container rim design in the area container base 21, and the like.

[0127] A tenth embodiment of the nebulizer 1 or transport lock 36 will now be explained in more detail with reference to Figs. 32 and 33. Fig. 32 corresponds to the view of Fig. 27. Fig. 33 corresponds to the view of Fig. 28.

[0128] The tenth embodiment differs from the ninth embodiment in principle only in the slightly simpler structure of the transport lock 36. Compared to the ninth embodiment, the gripper arms 48 are absent in the tenth embodiment. Instead, the locking arms 53 in the attached state additionally serve to fix and secure the insert element 50 in the axial direction to the base element 51 or part of the housing 18. In particular, the locking arms 53 engage the corresponding, preferably angular sections, over the insert element 50 or corresponding projections of the insert element 50, such as radial projections 52, to secure the insert element 50 from being lifted radially outward from the position shown in Fig. 32.

[0129] Fig. 33 shows the already unsecured or already open state of the transporting device 36. The locking arms 53 are pivoted, in particular rotated radially outwards, to axially release the cartridge element 50 and thus the container 3. In addition, in the position shown in Fig. 33, the cartridge element 50, together with the container 3, has already been placed on base element 51; this is done by the action of the handle 6 when tensioning the nebulizer 1 with the transport lock 36 open. The container 3 was thus pierced in the base in this condition.

[0130] Other aspects and explanations relating to the ninth embodiment are also generally applicable respectively or at least in a complementary manner also to the tenth embodiment.

[0131] Figs. 34 to 40 show the eleventh embodiment of the proposed nebulizer 1.

[0132] Fig. 34 shows the nebulizer 1 - or, more specifically, the lower part of the nebulizer 1 - in a schematic side view partially transparent in an intermediate state. The container 3 under it is not shown. The housing portion 18 is in a lower or first position in which the housing portion 18 is held axially spaced from the internal portion 17 by the upper housing portion 16 so that the container 3 in the housing portion 18 is still distant from the conveyor element or transport tube 9, that is, it has not yet been opened or punctured.

[0133] Fig. 35 is an axial cross-sectional view of the relative rotational position of the housing portion 18 with the internal portion 17 in the delivered condition. Fig. 36 shows the rotational position of the housing part 18 to the inner part 17 in the intermediate state shown in Fig. 34. Here, the housing part 18 rotates relative to the inner part 17 or to the delivered condition. FIG. 37 shows a partial cross-sectional side view of the housing portion 18 without the inner portion 17 but with the container 3 and transport lock 36 holding the container 3 in the housing portion 18. Figures 38 to 40 show side views in partial section of the housing portion 18 in different states.

[0134] The eleventh embodiment is, in principle, very similar to the seventh, eighth, ninth and / or tenth embodiment, and therefore we refer to the comments and explanations and illustrations contained therein which apply, respectively, or in addition. Only substantial differences or new aspects of the eleventh embodiment will be described in more detail below.

[0135] In the delivered condition shown in Fig. 35, it is prevented that the housing portion 18, preferably through a locking connection, is not axially (distal) pushed onto the inner portion 17 or close to the upper housing portion 16. Only after the housing portion has been rotated 18 relative to the inner portion 17 - preferably about 10 ° to 20 ° - in the intermediate position shown in Fig. 34 and 36 can (further) enter axially or activate nebulizer 1, and only then the container 3 is open and fluidly connected, as already explained in other examples.

[0136] The above-mentioned rotational movement of the housing part 18 relative to the inner portion 17 from the delivered position to the intermediate position is necessary to then allow the housing parts 18 to move axially or to activate the nebulizer 1. The axial lock of the housing part 18 in the delivered position thus provides protection against accidental starting the nebulizer 1. For example, this prevents the nebulizer 1 from being accidentally started when it is dropped.

[0137] During assembly, the housing part 18, together with the container 3 held therein by the transport lock 36, is first slid onto the inner part 17 or bottom part 17b of the inner part 17 only until the part of the housing 18 is inseparably connected, in particular locked and attached to the inner part 17. Particularly preferably in the delivered condition, the locking arms 28 with the locking projections 29 engage in the first security recesses 30 so that the housing portion 18 may no longer be separated or pulled out of the inner portion 17. In this delivered condition, the housing portion 18 is then at least initially protected by a locking connection before further axial insertion.

[0138] Locking to prevent further axial insertion in the delivered condition is preferably achieved in the illustrated embodiment by providing on the housing portion 18 at least one axial abutment 59, in particular at least two axial abutment 59 on opposite sides that abut preferably at least one radial projection 60 on the inner portion 17 in the delivered condition. The projections 59 are most clearly shown in the front view according to Fig. 36. Here, part of the housing 13 has already been turned into an intermediate position, so that the projections 60 do not overlap axially over projections 59, but engage with adjacent axial recesses 61. [0139] Rotation of the housing portion 18 relative to the internal portion 17 from the delivery position to an intermediate position is possible, among other things because the securing recesses 30 have a corresponding circumferential degree so that the locking protrusions 29 are able to slide or slide along the circumference on the the inner wall of housing portion 18, and more specifically in the intermediate position shown in Fig. 34.

[0140] The lock against further axial pushing of the housing parts 18 in the delivered condition can also be achieved using other structural elements.

[0141] When rotating the housing portion 18 from the delivery position to the intermediate position, some resistance must preferably be overcome. The swivel action can be rigid for this purpose. In the embodiment shown, the housing portion 18 moves into the delivery position and the intermediate position in a substantially snap manner (in the delivery position, the radial projections 59 engage in radial recesses 62 and in the intermediate position they are coupled to adjacent axial recesses 61 in the housing portion 18, so that some latching resistance must be overcome when moving from the delivery position to the intermediate position, while the housing part 18 and / or the inner part 17 are preferably radially elastically deformed or cause corresponding parts to flex flexibly.

[0142] Preferably, the locking device is also provided such that the housing parts 18 cannot be rotated back from the intermediate position to the delivery position. In the embodiment shown, at least one, preferably radially acting locking latch 63 is disposed on the inner portion 17, which initially engages in the delivery position in the first axially extending locking notch 64 in the housing portion 18 and in an intermediate position in the second axially extending locking notch 65. During the transition from the delivery position to the intermediate position - i.e. from the first locking cutout 64 to the second locking cutout 65 - the locking latch 63 may bend radially inwards. In the embodiment shown, two locking latches 63 are located on opposite sides together with their associated locking notches 64 and 65. Rotation back from the intermediate position to the delivery position can also be prevented by other structural elements.

[0143] In an eleventh embodiment, the activation of the nebulizer 1 requires a combination of rotational and translational motion. In particular, this combined movement results in good protection against accidental activation of the nebulizer 1.

[0144] Preferably, in the inactive state, i.e. when the housing part 18 is not fully inserted - the nebulizer is blocked to prevent tensioning of the pressure generator, i.e. in particular to prevent rotation of the inner part 17 relative to the upper part housing parts 16. This is particularly important when the nebulizer 1 is shipped delivered with the pressure generator 5 not tensioned. Accordingly, the nebulizer 1 has a barrier, such that the inner portion 17 can only be rotated relative to the upper housing portion 16 when the housing portion 18 has been fully retracted. This rotary barrier that is effective in particular in the delivered condition can also be used independently of the eleventh embodiment, in other embodiments in which the nebulizer 1 is delivered in an unstressed state.

[0145] The direction of rotation when moving the housing portion 18 from the delivery position to the intermediate position, preferably, extends in the opposite direction of rotation when the pressure generator 5 or nebulizer 1 is tensioned through the rotating housing parts 18 in the active state. However, rotation from the delivery position to the intermediate position can alternatively be made in the tensioning direction to tension the nebulizer 1 or pressure generator 5 at the same time, if desired.

[0146] In the embodiment shown, one of the radial projections 60 preferably forms a counting bearing or control device 23, in particular to the threaded spindle 66 in the device 23, shown in Fig. 34. The spindle 66 is preferably a slide (not shown) for indicating the number of doses that have already been taken or are still available. By rotating the spindle 66, the slider can be moved along the spindle 66. Preferably the window 67 (compare Figs. 35 and 36) is made in the housing portion 18 so that the axial position of the slider can be seen, even if the housing portion 18 is not otherwise transparent in the structure.

[0147] The eleventh embodiment has a transport lock 36, which differs significantly in structure from those in previous embodiments. The function of the transport lock 36, however, corresponds to the above remarks, and therefore only significant differences in the transport lock 36 will be discussed later.

[0148] Fig. 37 illustrates the preferred construction of the transport lock 36. The base member 51 is placed in the housing portion 18 and held by the safety arms 57. The transport lock 36 or base member 51 includes gripper arms 48 that fix the container 3 in the transport state shown. In particular, the gripper arms 48 engage in the radial and / or axial direction on the container 3 or pass to its base 21 in this state to protect the container 3 by friction or, more particularly, a locking connection. The gripper arms 48 are arranged on the circumference of the container 3.

[0149] The transport lock 36 also preferably has an annular securing element 68, which is provided with, in particular radially extending locking elements 69, which prevents the gripper arms 48 from bouncing radially outward in the secured state or transport state shown. In particular, fasteners 69 intended for this purpose engage in circumferential or lateral (hammer-shaped) projections 70 on the gripper arms 48 radially from the outside.

Preferably, the locking elements 69 are supported radially outwards on the inner wall of the housing part 18 (this prevents radial deformation and accordingly ensures that the gripper arms 48 are locked or locked by the locking coupling in the transport position that holds the container 3 through the locking connection, and are preferably held axially on the radial outer portion by a circumferential groove 71 and associated bead 72 on the housing portion 18, as shown in Fig. 38, or otherwise. Thus, the securing element 68 is axially secured and maintained in the transport condition. However, the security element 68 can be axially held directly or in any other way.

[0151] The locking elements 69 are connected to the securing element 68 by axial rods 73, so that they form spaces between them that are large enough for the gripper arms 48 to flex outwards when the transport lock 36 is opened and in the axial direction , in particular with the safety element 68 being pushed towards the base of the housing part 18, as will be described below.

[0152] Fig. 38 shows the housing part 18 with the inner part 17, already partially inserted so that the axial arms or projections 49 of the inner part 17 are already adjacent to the faces of the locking elements 69. Starting from this intermediate position, the container 18 is not yet fully pressed into the inner part 17 or nebulizer 1.

[0153] Fig. 39 shows the position with the housing part 18 fully inserted. The inner portion 17 has pushed the fastener 68 out of the fastening or transport position shown in Figs. 37 and 38 in the axial direction towards the bottom of the housing portion 18, so that the locking elements 69 do not secure the gripper arms 48 against axial deformation. During axial displacement, the inner portion 17 overcomes or cancels the locking connection, which is preferably provided between the housing portion 18 and the locking elements 69.

[0154] Furthermore, after reaching the position shown in Fig. 39, the inner part 17 has radially deflected gripper arms 48 by corresponding axial coupling and thereby opens the transport lock 36. In this position, the container 3 is already held in the front end by the handle 6, even if the container 6 may not yet be fully engaged in the holder 6.

[0155] During the subsequent tensioning of the nebulizer 1 or pressure generator 5 for the first time, the handle 6 is moved further axially towards the housing part 18, as a result of which the container 3 is latched at its front end to the handle 6, in the desired manner, probably already this has occurred and the container 3 is moved in its lower end axial position, so that it is open or pierced at the base by the piercing element 22, as shown in Fig. 40.

[0156] The nebulizer 1 preferably has an indicator device for indicating the active state or the open state of the transport lock 36. In the embodiment shown, this is achieved in that the housing part 18 has a lateral inspection window 74 in the base area. The peripheral, preferably differently colored part of the attachment element 68, and in particular the safety element 69, is visible through the inspection window 74 only when the transport lock 36 is open or the inner part 17 is fully engaged.

[0157] The transport lock 36 enables easy assembly, particularly easy insertion of the container 3 into the housing part 18, very secure holding of the container 3 in the transport position and easy reliable opening through the inner part 17 or the like. [0158] The transport lock 36 according to the eleventh embodiment may also be used in other embodiments.

[0159] Figs. 41 and 42 show schematic cross-sections through a twelfth embodiment of the proposed nebulizer 1. Fig. 41 shows the delivered condition. Fig. 42 shows the active state with the container 3 open.

[0160] Unlike other embodiments, in the twelfth embodiment, the nebulizer 1 is completely closed, and in particular, there is no need to press, press or otherwise mechanically (additionally) actuate the element, component or the like to activate or opening the container 3. Instead, the nebulizer 1 is activated or the container 3 is opened when the nebulizer 1 or the pressure generator 5 is tensioned for the first time.

[0161] In the twelfth embodiment, the container 3 and the transfer device for the fluid 2 in the nebulizer 1 are preferably matched so that the transport tube 9 or other transport element has not yet pierced the container 3 in the non-tensioned state of delivery of the nebulizer 1. Only during the tensioning tube 9 is introduced in the axial direction into the container 3, thereby opening the container 3 and the handle 6 is brought into engagement with the container 3. The advantage for the user is that he does not need to take any special steps to activate the device. On the contrary, the nebulizer 1 is automatically activated during normal operation, i.e. when it is tensioned for the first time. The pre-installed container 3 thus provides, in particular, simple and thus reliable operating means for the user.

[0162] Preferably, in the twelfth embodiment, as in most other embodiments, the housing portion 18 cannot be detached from the nebulizer 1. In particular, the housing portion 18 is locked in this position and is held in such a way that it is not removable. for example, in an inserted position by the locking arms 28 shown in Figs. 41 and 42.

[0163] Generally, it should be emphasized that in the proposed nebulizer 1, the container 3 can preferably be inserted, i.e. contained in the nebulizer 1. Consequently, the container 3 is preferably a separate component. However, the container 3 can theoretically be formed directly by the nebulizer 1 or parts of the nebulizer 1, or it may be otherwise embedded in the nebulizer 1.

As already mentioned, the individual features, aspects and / principles of the described embodiments can be combined with each other as desired and can be used in particular in the known nebulizer according to Figs. 1 and 2, but also in similar or other nebulizers.

[0165] In contrast to free standing equipment or the like, the proposed nebulizer 1 is preferably designed to be portable in particular a manually operated mobile device.

[0166] The proposed solution can, however, be used not only in the nebulizers 1 described in detail here, but also in other nebulizers or inhalers, for example powder nebulizers or so-called metered dose nebulizers.

[0167] Preferably, the fluid 2 is a liquid, as already mentioned, in particular an aqueous pharmaceutical preparation. However, it can also be another pharmaceutical preparation, suspension and the like.

[0168] According to an alternative example, the fluid 2 may also contain particles or a powder. In this case, instead of the blowing nozzle 12, another type of feed device may be provided, in particular a blowout opening (not shown) or feed channel (not shown) for supplying fluid or powder, or the like for mouthpiece 13. The optional air supply opening 15 then serves to supply ambient air preferably in parallel, so that it generally or allows sufficient air to flow for breathing or inhalation through the mouthpiece 13.

[0169] If desired, the fluid 2 can be sprayed with a propellant. [0170] Preferred components and / or compositions of preferred therapeutic fluid 2 are listed below. As already indicated, they may be aqueous or non-aqueous solutions, mixtures, compositions containing ethanol or solvent-free, or the like. It is particularly advantageous for fluid 2 to include: As pharmaceutically active substances, substance compositions or mixtures of substances, all inhalable compounds are used, such as, for example, inhalable macromolecules as disclosed in EP 1 003 478. Preferably, the substances , compositions of substances or mixtures of substances for the treatment of respiratory ailments and administered by inhalation are used.

[0171] Particularly preferred pharmaceutical compositions in this context are those selected from anticholinergics, betamimetics, steroids, phosphodiesterase IV inhibitors, LTD4 antagonists and EGFR kinase inhibitors, antiallergic agents, ergot alkaloid derivatives, triptans, CGRP antagonists, phosphodiesterase V inhibitors and combinations of these active ingredients, e.g. betamimetics plus anticholinergics or betamimetics plus antiallergics. In the case of combinations, it is preferred that at least one of the active ingredients contains chemically bound water. Preferably, the active substances containing the anticholinergic agent are used as one-component preparations or in the form of combined preparations.

[0172] In particular, the following are examples of active ingredients or their salts: anticholinergic agents that can be used are preferably selected from tiotropium bromide, oxytropium bromide, flutropium bromide, ipratropium bromide, glucopyrronium salt, trospium chloride, tolterodine, 2,2-diphenylpropionate, methyl bromide, tropenol methyl, 2,2-diphenylpropionate, methyl bromide Skopine methylbromide-2,2-diphenylacetate, Tropenol methylbromide 2-fluoro-2,2-diphenylacetate, 3,3 ', 4,4'-tropenol methylbromide bromide, Skopine methylbromide 3,3 ', 4,4'-tetrafluorobenzylate, Tropenol methylbromide 4,4-difluorobenzylate, Skopine methylbromide 4,4-difluorobenzylate, Tropenol 3,3'-difluorobenzylate, Tropenol methylbromide, 3,3'-difluorobenzzylate tropenol methyl bromide hydroxy-fluorene-9-carboxylate, tropenol methyl bromide 9-fluoro fluorene-9 carboxylate, skopine methyl bromide 9-hydroxy fluorene-9-carboxylate, skopine methyl bromide 9-fluoro fluorine-9-carboxylate, Tropenol methyl bromide 9-methyl fluorene-9-carboxylate, Skopine methyl bromide 9-methyl fluorene-9-carboxylate, Cyclopropyltropine methyl bromide benzylate, Cyclopropyltropine methyl bromide 2,2-diphenylpropionate, 9-Hydroxylxanthine 9-carboxylic acid methylpropyltrichloride cyclopropylotropin methyl bromide carboxylate, cyclopropylotropin methyl bromide 9-methyl xanthene-9 carboxylate, cyclopropylotropin methyl bromide 9-hydroxy-fluorene-9-carboxylate, Methyl 4,4-difluorobenzylate cyclopropyltropine methyl bromide, 9-hydroxy-xanthene 9-carboxylate, tropenol methyl bromide, 9-hydroxy-xanthene-9-carboxylate, scopine methyl bromide, 9-methyl-xanthene-9-carboxylate, tropenol methyl bromide, 9-methyl-xanthene Skopine methyl bromide carboxylate, Tropenol methyl bromide 9-ethylxanthene-9-carboxylate, Tropenol methyl bromide 9-difluoromethylidene-xanthene-9-carboxylate and Skopine methyl bromide 9-hydroxy-xanthene-9-carboxylate optionally in the form of their racemates, enantiomers or diastereomers and optionally in the form of their solvates and / or hydrates.

[0173] Betamimetics that can be used are preferably selected from albuterol, bamboouterol, bitolterol, broxaterol, carbuterol, clenbuterol, phenoterol, formoterol, hexoprenaline, ibuterol, indacaterol, isoetharin, isoprenaline, levosalbutamol, mabuterol, orrenalapel pirbuterol, procaterol, reproterol, rymiterol, ritodrine, salmeterol, salmefamol, soterenot, sulfonterol, thiaramide, terbutaline, tolubuterol, CHF-1035, HOKU-81, KUL-1248, 3- (4- {6- [2-hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) ethylamino] hexyloxy} butyl) benzol sulfonamide, 5- [2- (5,6 diethyl-indan- 2-ylamino) -1-hydroxy-ethyl] -8-hydroxy-1H-quinolin-2-one, 4-hydroxy-7- [2 - {[2 - {[3- (2-phenylethoxy) propyl] sulfonyl } ethyl] -amino} ethyl] -2- (3H) -benzothiazolone, 1 (2-fluoro-4-hydroxyphenyl) -2- [4- (1-benzimidazolyl) -2-methyl-2-butylamino] ethanol, 1- [3- (4-methoxybenzyl-amino) -4-hydroxyphenyl] -2- [4- (1-benzimidazolyl) -2-methyl-2-butylamino] ethanol, 1- [2H-5-hydroxy-3-oxo-4H- 1,4-benzoxazin-8-yl] -2- [3- (4-N, N-dimethylaminophenyl) -2-methyl-2-propylamino] ethanol, 1- [2H-5-hydroxy-3-oxo-4H-1 , 4-benzoxazin-8-yl] -2- [3- (4-methoxyphenyl) -2-methyl-2-propylamino] ethanol, 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8- yl] -2- [3- (4-n-butyloxyphenyl) -2-methyl-2propylamino] ethanol, 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- {4- [3- (4-methoxyphenyl) -1,2,4-triazol-3-yl] -2-methyl-2-butylamino} ethanol, 5-hydroxy-8- (1-hydroxy2-isopropylaminobutyl) -2H-1,4-benzoxazin-3- (4H) -one, 1- (4-amino-3- chloro-5-trifluoromethylphenyl) -2-tert-butylamino) ethanol and 1- (4-ethoxycarbonyl-amino-3-cyano-5-fluorophenyl) -2- (tert-butylamino) ethanol, optionally in the form of their racemates, enantiomers or diastereomers and optionally in the form of pharmacologically acceptable acid addition salts, their solvates and / or hydrates.

[0174] Steroids that can be used are preferably selected from prednisolone, prednisone, butxocortpropionate, RPR-106541, flunizolid, beclometasone, triamcinolone, budesonide, fluticasone, mometasone, ciclesonide, rofleponide, ST-126, dexamethasone -6a, 9a-difluoro-17a - [(2-furanylcarbonyl) oxy] -1-hydroxy-16a-methyl-332 oxo-androsta-1,4-diene-17e-carbothioate, (S) - (2-oxo-tetrahydro-furan-3S-yl) 6α, 9αdifluoro-1ie-hydroxy-16a-methyl-3-oxo-17a-propionyloxy-androsta-1,4-diene-17carbothionate and etiprednol dichloroacetate ( BNP-166), optionally in the form of their racemates, enantiomers or diastereomers, and optionally in the form of their salts and derivatives, their solvates and / or hydrates.

[0175] PDE IV inhibitors that can be used are preferably selected from enprophylline, theophylline, roflumilast, ariflo (cilomilast), CP-325366, BY343, D-4396 (Sch-351591), AWD-12281 (GW- 842470) , N- (3,5-dichloro-1-oxo-pyridin-4-yl -4-difluoromethoxy-3-cyclopropylmethoxybenzamide, NCS-613, pumafentine, (-) p - [(4aR *, 10bS *) - 9-ethoxy1, 2,3,4,4a, 10b-hexahydro-8-methoxy-2-methylbenzo [s] [1,6] naphthyridin-6-yl] -N, Ndiizopropylobenzamidu, (R) - (+) - 1- (4-bromobenzyl) -4 - [(3-cyclopentyloxy) -4-methoxyphenyl] -2-pyrrolidone, 3- (cyclopentyloxy-4-methoxyphenyl) -1- (4-N'- [N-2-Cyano-Smethyl-isothioureido] benzyl) -2-pyrrolidone, cis [4-cyano-4- (3-cyclopentyloxy-4-methoxyphenyl) cyclohexane-1-carboxylic acid], 2-carbomethoxy-4-cyano-4 - (3-cyclopropylmethoxy-4-difluoromethoxyphenyl) cyclohexan-1-one, cis [4-cyano-4- (3-cyclopropyl-methoxy-4-difluoromethoxyphenyl) cyclohexan-1-ol], (R) - (+) - [4- (3-cyclopentyloxy-4-methoxyphenyl) pyrrolidin-2-ylidene] ethyl acetate, (S) - (-) - [4- (3-cyclopentyloxy-4-methoxyphenyl) pyrrolidin-2-ylidene ] ethyl acetate, CDP840, Bay-198004, D4418, PD-168787, T-440, T-2585, arophylline, atizoram, V-11294A, Cl-1018, CDC-801, CDC-3052, D-22888, YM - 58997, Z-15370, 9-cyclopentyl-5,6-dihydro-7-ethyl-3- (2-thienyl) -9H-pyrazolo [3,4-c] -1,2,4-triazolo [4,3-a ] pyridine and 9-cyclopentyl-5,6-dihydro-7-ethyl-3- (tert-butyl) -9H-pyrazolo [3,4-c] -1,2,4-triazolo [4.3 a] pyridine, optionally in the form of their racemates, enantiomers or diastereomers, and optionally in the form of their pharmacologically acceptable acid addition salts, their solvates and / or hydrates.

[0176] LTD4 antagonists that can be used are preferably selected from montelukast, 1 - (((R) - (3- (2- (6,7-difluoro-2-quinolinyl) ethenyl) phenyl) -3- (2- (2-hydroxy-2-propyl) phenyl) thio) methylcyclopropane-acetic acid, 1 - ((((1 (R) -3 (3- (2- (2,3-dichlorothieno [3,2-b] pyridin-5 -y10) - (E) -ethyl) phenyl) -3- (2- (1-hydroxy-1-methylethyl) phenyl) propyl) thio) methyl) cyclopropane acetic acid, pranlukast, zafirlukast, acid [2 - [[2- ( 4-tert-butyl-2-thiazolyl) -5-benzofuranyl] oxymethyl] phenyl] acetic acid, MCC847 (ZD-3523), MN-001, MEN-91507 (LM-1507), VUF-5078, VUF-K-8707 and L-733321, optionally in the form of their racemates, enantiomers or their diastereomers, optionally in their pharmacological form acceptable acid addition salts and optionally in the form of their salts and derivatives, their solvates and / or hydrates.

[0177] EGFR kinase inhibitors that can be used are preferably selected from cetuximab, trastuzumab, ABXEGF, Mab ICR-62, 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4 (morpholin- 4-yl) -1-oxo-2-buten-1-yl] amino} -7-cyclopropylmethoxy-quinazoline, 4 - [(R) - (1-phenyl-ethyl) amino] -6 - {[4- (morpholin- 4-yl) -1-oxo-2-buten-1-yl] amino} -733 cyclopentyloxyquinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6 - {[4 - ((R) -6-methyl-2-oxomorpholin-4-yl) -1-oxo-2-buten-1 yl] amino} -7 - [(S) - (tetrahydrofuran-3-yl) oxy] quinazoline,

4 - [(3-chloro-4-fluoro-phenyl) amino] -6- [2- ((S) -6-methyl-2-oxo-morpholin-4-yl) -ethoxy] -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6 - ({4- [N- (2-methoxy-ethyl) -N-methyl-amino] -1-oxo-2-buten-1-yl} amino) -7-cyclopropylmethoxy-quinazoline, 4 - [(R) - (1-phenyl-ethyl) amino] -6 - ({4- [N- (tetrahydropyran-4-yl) -N-methyl-amino] -1-oxo 2-buten-1-yl} amino) -7-cyclopropylmethoxy-quinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6 - ({4- [N (2-methoxy-ethyl) -N-methyl-amino] -1-oxo-2-buten-1-yl} amino) -7-cyclopentyloxyquinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7 - [(R) - (tetrahydrofuran-2-yl) methoxy] quinazoline, 4 - [(3-ethynyl-phenyl) amino] 6,7-bis- (2-methoxy-ethoxy) quinazoline, 4 - [( R) - (1-phenyl-ethyl) amino] -6- (4-hydroxy-phenyl) 7H-pyrrolo [2,3-d] pyrimidine, 3-cyano-4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7-ethoxy- quinolines, 4 - [(R) - (1-phenylethyl) amino] -6- {[4 - ((R) -6-methyl-2-oxo-morpholin-4-yl) -1-oxo-2-butene -1-yl] amino} -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (morpholin-4-yl) -1-oxo-2-butene-1-yl ] amino} -7 - [(tetrahydrofuran-2-yl) methoxy] quinazoline, 4 - [(3-ethynylphenyl) amino] -6 - {[4- (5,5-dimethyl-2-oxo-morpholin-4 yl) -1-oxo-2-buten-1-yl] amino} quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- {2- [4- (2-oxomorpholin-4-yl) -piperidin-1-yl] ethoxy} -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (trans-4-aminocyclohexan-1-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] - 6- (trans-4-methanesulfonylaminocyclohexan-1-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6- (tetrahydropyran-3-yloxy) -7-methoxyquinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6- {1 - [(morpholin-4-yl) carbonyl] piperidin-4-yloxy} -7-methoxyquinazoline, 4 [(3-chloro -4-fluoro-phenyl) amino] -6- (piperidin-3-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- [1- (2-acetylamino -ethyl) -piperidin-4-yloxy] -7-methoxyquinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (4-tetrahydropyran-4-yloxy) -7-ethoxyquinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- {trans-4- [(morpholin-4-yl) carbonylamino] cyclohexan-1-yloxy} -7-methoxy-quinazoline, 4- [ (3-chloro-4-fluoro-phenyl) amino] -6- {1 [(piperidin-1-yl) carbonyl] -piperidin-4-yloxy} -7-methoxy-quinazoline, 4 - [(3-chloro- 4-fluoro-phenyl) amino] -6- (cis-4- {N - [(morpholin-4-yl) carbonyl] -N-methyl-amino} -cyclohexan-1-yloxy) -7-methoxy-quinazoline, 4 - [( 3-chloro-4-fluoro-phenyl) amino] -6- (trans-4etansulfonylamino-cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7- (2-methoxy-ethoxy) quinazoline, 4 - [(3-chloro-4 -fluoro-phenyl) amino] -6- [1- (2-methoxy-acetyl) -piperidin-4-yloxy] -7- (2-methoxyethoxy) -quinazoline, 4 - [(3-ethynyl-phenyl) amino] -6- (tetrahydropyran-4-yloxy] -7-methoxyquinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (cis-4- {N - [(piperidin-1-yl) carbonyl] -N-methyl-amino} -cyclohexane-1-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6- {cis-4 - [(morpholin-4-yl) carbonylamino] -cyclohexan-1-yloxy} -7-methoxy-quinazoline, 4 - [(3 -chloro-4-fluoro-phenyl) amino] -6- {1- [2- (2-oxopyrrolidin-1-yl) ethyl] piperidin-4-yloxy} -7-methoxy-quinazoline, 4 - [(3-ethynyl) phenyl) amino] -6- (1-acetyl-piperidin-4-yloxy) -7-methoxy-quinazoline, 4 - [(3-ethynyl-phenyl) amino] -6- (1-methyl-piperidin-4-yloxy) -7- methoxy-quinazoline, 4 - [(3-ethynyl-phenyl) amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (1-methyl-piperidin-4-yloxy) -7- (2-methoxy-ethoxy) -quinazoline, 4 - [(3-ethynyl-phenyl) ) amino] -6- {1 [(morpholin-4-yl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6- {1- [(N-methyl-N-2-methoxyethylamino) carbonyl] -piperidin-4-yloxy} -7-methoxy quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (1-ethyl-piperidine -4-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluorophenyl) amino] -6- [cis-4- (N-methanesulfonyl-N-methyl-amino) -cyclohexan-1-yloxy] -7-methoxy-quinazoline, 4 - [(3 -chloro-4-fluorophenyl) amino] -6- [cis-4- (N-acetyl-N-methyl-amino) -cyclohexan-1-yloxy] -7-methoxyquinazoline, 4 - [(3-chloro-4- fluoro-phenyl) amino] -6- (trans-4-methylamino-cyclohexan-1-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- [trans-4 - (Nmetanosulfonylo-N-methyl-amino) -cyclohexane-1-yloxy] -7-methoxy-quinazoline, 4 - [(3-chloro4-fluoro-phenyl) amino] -6- (trans-4-dimethylaminocyclohexan-1-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino ] -6- (trans-4- {N - [(morpholin-4-yl) carbonyl] -N-methylamino} cyclohexan-1-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4- fluoro-phenyl) amino] -6- [2- (2,2-dimethyl-6-oxo-morpholin-4-yl) -ethoxy] -7 - [(S) - (tetrahydrofuran-2-yl) methoxy] quinazoline 4 - [(3-chloro-4-fluorophenyl) amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7-methoxy-quinazoline, 4 - [(3-chloro-4-fluoro-phenyl) amino] -6- (1-cyanopiperidin-4-yloxy) -7-methoxy-quinazoline and 4 - [(3-chloro-4-fluoro-phenyl) amino] - 6- {1 - [(2-methoxyethyl) carbonyl] piperidin-4-yloxy} -7-methoxy-quinazoline, optionally in the form of racemates, enantiomers or diastereomers, optionally in the form of their pharmacologically acceptable acid addition salts, their solvates and / or hydrates.

[0178] By acid addition salts, salts with pharmacologically acceptable acids, which compounds may optionally be able to form, are considered, for example, salts selected from hydrochloride, hydrobromide, hydroiodide, persulfate, hydrogen phosphate, hydrogen methanesulfonate, hydrogen nitrate, hydrogen maleate, hydrogen acetate , hydrogen benzoate, hydrogen citrate, hydrogen fumarate, hydrogen tartrate, hydrogen oxalate, hydrogen succinate, hydrogen benzoate and hydrogen p-toluenesulfonate, preferably the hydrochloride, hydrobromide, hydrogen sulfate, hydrogen phosphate, hydrogen fumarate and hydrogen methanesulfonate. [0179] Examples of antiallergic agents are: disodium cromoglycate, nedocromil. [0180] Examples of ergot alkaloid derivatives are: dihydroergotamine, ergotamine. [0181] For inhalation, it is possible to use pharmaceutical compositions, pharmaceutical formulations and mixtures, including the above-mentioned active substances, as well as their salts, esters and combinations thereof, salts and esters.

List of reference nebulizer fluid container bag pressure generator handle drive spring locking element transport tube check valve pressure chamber blow-off nozzle mouthpiece aerosol air inlet opening upper part of the housing internal part

17a upper part of the inner part

17b lower part of the inner part casing (bottom part) securing element spring (bottom part of the casing) container base piercing element control device sealing baffle vent hole securing element securing arm locking protrusion locking recess securing recess protective recess first telescopic part second telescopic part basic part bead block transport bead / shoulder securing element actuating arm ring guiding sleeve insert rod securing rod / ring part hollow projection hollow cylindrical blocking blocking part gripping arm axial arm / protrusion insert element basic element radial shoulder blocking arm radial thrust shoulder sliding slope ramp arm protective bag axial thrust shoulder radial projection axial recess radial recess locking latch first locking notch second locking notch spindle window securing element blocking element peripheral circumferential groove circumferential bead axial rod sight glass

Boehringer Ingelheim International GmbH, Germany

Proxy:

EP 1 883 439 B1 Z-14004/16