Retinol containing water-in-oil type emulsion, method of obtaining same,its application and package therefor
18 claims: 2 independent, 16 dependent
- 1Zastrzeżenia patentowe 1. Emulsja typu woda w oleju zawieraj ąca retinol, fazę tłuszczową, fazę wodną i środek do emulgowania fazy wodnej w fazie tłuszczowej, do zastosowania zwłaszcza w kosmetyce lub dermatologii, znamienna tym, że zawiera retinol w ilości 0,001% do 10% całkowitego ciężaru emulsji, fazę tłuszczową, zawierającą od 0,5% do 10% wag. emulgatora stanowiącą od 10% do 50% całkowitego ciężaru emulsji i obejmującą co najmniej jeden organiczny rozpuszczalnik retinolu, w ilości od 0,01 do 30%całkowitego ciężaru emulsji, i który jest ciekły w temperaturze pokojowej oraz wybranyjest z grupy obejmującej alifatyczne alkohole tłuszczowe o 16-20 atomach węgla, o łańcuchu rozgałęzionym, diestry kwasów dikarboksylowych o 6-14 atomach węgla z alkoholem izopropylowym oraz triglicerydy kwasów tłuszczowych o 6-18 atomach węgla i ich mieszaniny, oraz fazę wodną stanowiącą od 50% do 90% całkowitego ciężaru emulsji, przy czym pH fazy wodnej znajduje się w zakresie zasadowym.
- 2Emulsja według zastrz. 1, znamienna tym, że jest wolna od jakiegokolwiek odczynnika chelatującego jony metali.
- 3Emulsja według zastrz. 1, znamienna tym, że zawiera fazę tłuszczową stanowiącą od 20% do 35% całkowitego ciężaru emulsji.
- 4Emulsja według zastrz. 1, znamienna tym, że zawiera fazę wodną stanowiącą od 65 do 80% całkowitego ciężaru emulsji.
- 5Emulsja według zastrz. 1, znamienna tym, że zawiera retinol w ilości wynoszącej od 0,01% do 1% całkowitego ciężaru emulsji.
- 6Emulsja według zastrz. 1, znamienna tym, że zawiera rozpuszczalnik organiczny, który stanowi od 0,1% do 10% całkowitego ciężaru emulsji.
- 7Emulsja według zastrz. 1, znamienna tym, że jako retinol zawiera all-trans-Retinol.
- 8Emulsja według zastrz. 1, znamienna tym, że jako środek emulgujący zawiera środek emulgujący zawierający krzem.
- 9Emulsja według zastrz. 1 albo 8, znamienna tym, że obejmuje środek emulgujący zawierający krzem, w ilości wynoszącej od 1% do 6% całkowitego ciężaru emulsji.
- 10Emulsja według zastrz. 1, znamienna tym, że zawiera środek emulgujący wybrany z grupy obejmującej kopoliole typu polioksyetylenowanego i/lub polioksypropylenowanego C 10 . 22 - a lkilodimetikonu, i ich mieszaniny.
- 11Emulsja według zastrz. 1, znamienna tym, że zawiera fazę tłuszczowązawierającądodatkowy olej obojętny w stosunku do retinolu.
- 12Emulsja według zastrz. 1, znamienna tym, że zawiera dodatkowy olej wybrany z grupy obejmującej oleje mineralne i oleje zawierające krzem.
- 13Emulsja według zastrz. 1, znamienna tym, że zawiera olej wybrany z grupy obejmującej izoheksadekan, izoparafinę, petrolatum, parafinę, dimetikony, dimetikonole, cyklometikony i alkilodimetikony.
- 14Emulsja według zastrz. 1, znamienna tym, że pH fazy wodnej mieści się w zakresie od 8,5 do 9,5.
- 15Emulsja według zastrz. 1, znamienna tym, że obejmuje fazę wodną zawierającą zasadę wybraną z grupy obejmującej trietanoloaminę, aminometylopropanol, aminometylopropanodiol, tris(aminometylopropanotriol), wodorotlenek sodowy, argininę i lizynę.
- 16Emulsja według zastrz. 1, znamienna tym, że zawiera co najmniej jeden dodatek wybrany z grupy obejmującej poliole, glikole, sole stabilizujące, żel bentonitowy, ciężkie lub polietylenowane woski oraz petrolatum. 177 705
- 17Emulsja według zastrz. 1, znamienna tym, że zawiera co najmniej jedną sól stabilizującą w ilości wynoszącej od 0,3% do 2% całkowitego ciężaru emulsji.
- 18Opakowanie dla produktu obejmującego emulsję typu woda w oleju zawierającą retinol, w postaci pojemnika z zespołem dozującym pracującym bez pobierania powietrza, znamienne tym, że zespół dozujący (8) składa się z kołpaka (10) wypukłego w kierunku na zewnątrz i wyposażonego w co najmniej jedną szczelinę (12), znajdującą się na wierzchołku kołpaka (10) przy czym kształtowane termicznie ściany (4) pojemnika (3) są wykonane z materiału nieprzepuszczalnego dla gazów i dla promieniowania UV, a na powierzchni tych ścian (4) znajduje się materiał niemetaliczny, zaś wewnątrz pojemnika (3) znajduje się kieszonka (20) z zespołem wychwytującym tlen, posiadająca ścianki (22) w postaci membrany wykonanej z matriału przepuszczalnego dla gazów, ale nieprzepuszczalnego dla cieczy, osłaniające zamknięty wewnątrz absorber tlenu (24).
Independent claims18
132 paragraphs, as filed
The present invention relates to a water-in-oil emulsion containing retinol and its packaging.
More specifically, the invention relates to water-in-oil emulsions containing stabilized retinol, wherein such emulsions are specifically intended for use in cosmetics and / or dermatology. The invention relates to packaging perfectly suited for these emulsions.
Retinol is known for its beneficial effects on the skin, in particular for topical use.
Retinol has been used for a long time to treat acne. However, retinol has been shown to be remarkably active in repairing damage caused by either aging or excessive exposure to solar radiation.
Therefore, given the effect of retinol on cell differentiation, one can imagine its use, among other things, to effectively combat the appearance of wrinkles and fine bands, and to combat dryness, roughness and / or inflexibility of the skin. Its activity in terms of tissue regeneration makes it a very important compound when it comes to participating in the scarring process. Repeated application of cosmetic compositions containing retinol allows, among others, to remove wrinkles, give the skin smoothness and repair small cracks in the epidermis.
Because of these beneficial effects, a search for such a method of formulating retinol into cosmetically acceptable compositions has been ongoing for a very long time, which would ensure that a formulation that is stable for at least a few months at room temperature is obtained.
Retinol-containing emulsions that can be used in cosmetics are described in detail in US-A-4826828 and in International Patent Application WO-A-93/00085.
US-A-4,826,828 relates to water-in-oil emulsions containing retinol, a volatile silicon compound and a retinol solvent and a volatile silicon compound. Ethanol is the preferred solvent in this case. However, it has now been shown that retinol degrades in the presence of ethanol. In order to form an emulsion, US-A-4,826,828 indicates the preparation of a solution containing retinol, which should be mixed during use (to avoid any decomposition) into a water-in-oil emulsion. In addition, the use of an antioxidant and a metal chelating agent in the aqueous phase was indicated, which is to play a key role.
The stability of this type of composition does not exceed one month, as indicated by the owner of US-A-4,826,828 regarding the packaging of his Bioadvance and Bioadvance 2000 products described in this patent. Thus, the stability of retinol in compositions of this type is not sufficient in terms of their long-term duration
177 705 use, which implies the need to quickly re-purchase a new portion of the preparation and makes its use very expensive.
International patent application WO-A-93/00085 proposes a method of stabilizing retinol in pharmaceutical compositions, consisting in incorporating a stabilizing complex comprising a combination of an antioxidant and a metal ion chelating reagent. However, although the stability of retinol in such compositions appears to be enhanced (after storage for 3 months at 40 ° C, the composition still has 60% retinol present), the fact is that the relative stability of retinol is only due to the presence in the composition of a significant amount of fixative antioxidants and chelating agents.
A lot of research has been carried out to minimize or even completely eliminate such stabilizing agents from cosmetic compositions containing retinol, but at the same time maintaining its stability in the composition at an acceptable level from the viewpoint of the effects of the composition and in connection with the prolonged period of its use.
It has now been found, surprisingly and unexpectedly, that it is possible to formulate a water-in-oil emulsion containing retinol, showing good stability over time, intended for topical use, the formulation being based on the appropriate selection of various components of the emulsion to give it particular properties physicochemical.
The subject of the invention is therefore a water-in-oil emulsion containing retinol, a fat phase and an aqueous phase for use especially in cosmetics or dermatology, characterized in that it contains retinol in an amount of 0.001% to 10% of the total weight of the emulsion, fat phase containing from 0, 5% to 10% by weight emulsifier from 10<sup>0</sup>% to 50% of the total weight of the emulsion and comprising at least one organic retinol solvent in an amount of from 0.01% to 30% of the total weight of the emulsion, which is liquid at room temperature and selected from the group consisting of 16-20 carbon aliphatic fatty alcohols , branched chain, dicarboxylic acid diesters with 6-14 carbon atoms with isopropyl alcohol and triglycerides of fatty acids with 6-18 carbon atoms and mixtures thereof, and an aqueous phase constituting from 50% to 90% of the total weight of the emulsion, wherein the pH of the aqueous phase is in the basic range.
Studies carried out on the emulsion according to the invention have shown that retinol stability is clearly improved compared to the prior art formulations.
The emulsion according to the invention has the advantage of being able to keep the active retinol content at 82% after 2 months of storage at 45 ° C.
The emulsion according to the invention is well suited for use in cosmetics and / or dermatology.
The relative proportions of the individual components of the emulsions according to the invention are chosen in such a way that they correspond to the proportions usually used in cosmetics or dermatology preparations, depending on the particular applications envisaged.
In addition, in a preferred embodiment of the invention, the emulsion according to the invention does not contain any metal ion chelating reagent and, optionally, an antioxidant.
In particular, it is preferred that the fat phase of the emulsion according to the invention can constitute from 20% to 35% of the total weight of the emulsion.
In addition, it is preferred that the aqueous phase of the emulsions of this invention be from 65% to 80% of the total weight of the emulsion.
Retinol is generally present in the emulsion of the invention in an amount preferably in the range of 0.01% to 1% of the total weight of the emulsion.
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As retinol used in the emulsion of the present invention, retinol of any conformation can be used, especially retinol in all-trans form, such as is sold by Fuka under the name "all-trans-Retinol". The distinguishing feature of all-transRetinoluje is that its retinoid activity and painlessness surpasses other retinoids.
The organic retinol solvent may preferably comprise from 0.1% to 10% of the total weight of the emulsion.
As the organic solvent, maintaining fluidity at room temperature (e.g. 20 ° C), used in the process of the invention, the above-mentioned organic solvents capable of dissolving retinol, while maintaining good retinol stability, are used.
Fatty alcohol straight or branched chain solvents that can be alkoxylated destroy the stability of the inventive emulsion.
Of the aliphatic fatty alcohols with 16-20 carbon atoms that can be used in the process of the invention, mention may be made of 2-hexyl-decanol, such as is sold by Condea under the name "Isofol 16", and octyldodecanol, such as is sold by Henkel under the name "Eutanol G" and with isostearyl alcohol such as is sold by Sherex under the name "Adol 66".
Among the dicarboxylic acid diesters with 6-14 carbon atoms with isopropyl alcohol which they can use in the process of the invention, mention may be made of diisopropyl adipate, such as is sold by the company ISP under the name "Ceraphyl 230".
Of the triglycerides of fatty acids with 6-18 carbon atoms that can be used in the process of the invention, preferably mixed decane / octanoic acid triglycerides such as triglycerides sold by the company Huels France under the name "Miglyol 812" are preferably used.
In a particular embodiment of the invention, it is possible to use a mixture of two or more such retinol solvents.
Other typical ingredients of cosmetic, pharmaceutical or veterinary compositions can be incorporated into the emulsions of the invention. The nature of these ingredients and their quantitative content in the emulsion should be consistent with the level of stability sought for the retinol contained in the emulsions of the invention.
The fat phase of the emulsions of this invention may contain an emulsifying agent having the ability to form water-in-oil emulsions and withstand conditions existing in the alkaline pH range. In particular, such an emulsifier is a silicon containing emulsifier, and it is preferably used in an amount of 1% to 6% of the total weight of the emulsion. Among the emulsifying agents that can be included in the fat phase, polyoxyethylene C type copolyols can be mentioned.<sub>10</sub>.<sub>2</sub>2-alkyl dimethicone, such as a cetyl dimethicone copolyol or an "Abil EM-90" emulsifier from Goldschmidt, or a polyoxyethylene and polyoxypropylene lauryl dimethicone type copolyol, for example an emulsifier called "Q2-5200" from Dow Corning, or a mixture of both .
You can also use polyoxyethylene dimethicone copolyols in the form of an emulsifier called "SP 1228" from General Electric, as well as an emulsifier called "Q2-3225 C" from Dow Corning.
The fat phase may also contain an additional oil, other than an emulsifying agent, inert to retinol, preferably selected from mineral oils or silicon containing oils.
Among the mineral oils that can be used in the process of the invention, mention may be made of, among others, isohexadecane, paraffin, isoparaffin and petrolatum.
Among the silicon-containing oils that can be used in the process of the invention, mention may be made, inter alia, of dimethicones, dimethiconols, cyclomethicones such as cyclopentadimethylsiloxane (or cyclomethicone D5) or cyclohexadimethylsiloxane (or cyclone6)
177 705 tikon D6) or alkyl dimethicone, as well as a mixture of some of these compounds, such as the product called "gum Q2-1401" from Dow Corning.
The aqueous phase of the emulsions of this invention is alkaline, above pH 8, preferably in the range of pH 8.5 to pH 9.5. The desired pH value of the aqueous phase is obtained by adding any base in accordance with the requirements regarding retinol stability in the emulsion according to the invention. It is introduced in an amount that is adequate to obtain the desired pH in the aqueous phase. In practice, the base is used in an amount ranging from 0.05% to 0.5% of the total weight of the emulsion.
Examples of bases used in the process of the invention include triethanolamine, aminomethylpropanol, aminomethylpropanediol, tris (aminomethylpropanetriol), sodium hydroxide, arginine and lysine.
The emulsion according to the invention may additionally contain hydrophilic or lipophilic additives, usually used in the preparation of cosmetic or dermatological compositions.
Among the hydrophilic additives used in the preparation of the emulsions of the invention, mention may be made of moisturizing agents such as polyols, including glycerin, and glycols.
Among the lipophilic additives, mention may be made of gelling agents such as bentonite gel, for example, such as those sold under the name "Simagel Si 345" by Biophil, as well as polyethylene waxes, such as those sold by Allied Chemical. a product called "Polyethylene Wax AC 617".
The emulsion according to the invention preferably contains stabilizing salts in an amount of, for example, from 0.3% to 2% of the total weight of the emulsion, namely salts such as sodium chloride (NaCl) and potassium chloride (KCl).
The emulsion according to the invention is used for the treatment of the skin, in particular for the treatment of acne, as well as for the treatment of damage caused by aging and / or the action of solar radiation.
The invention also includes packaging suitable for the emulsion described above. The packaging for a product containing a water-in-oil emulsion containing retinol, in the form of a container with a dispensing assembly operating without air intake, is characterized in that the dispensing assembly consists of a convex cap convex towards the outside and equipped with at least one slot at the top of the cap , the thermoformed container walls are made of gas and UV radiation impervious material, and on the surface of these walls there is a non-metallic material, and inside the container there is a pocket with an oxygen capture unit, having walls made of a membrane permeable to gases and impermeable to liquids, enclosing the oxygen absorber enclosed inside.
The product contained in the packaging comes into contact with the surroundings only when applied to the skin.
The dispensing assembly may consist of a valve or pump operating without air intake and may be an assembly as described in patent application FR-A-2666308 or patent application FR-A-2658739.
According to one particular variant of the method of carrying out the invention, the oxygen scavenging assembly is separated from the contained product by a membrane permeable to gases and impermeable to liquids, especially for those liquids which are included in the emulsion according to the invention.
As the gas-permeable membrane, for example, a membrane such as that described in patent application FR-A-2671055 made of polyethylene, polypropylene, a mixture of polyethylene and terphthalate or a mixture of thin layers of polyolefins and / or polyesters can be used. These membranes have a permeability of 150 cm<sup>3</sup>/ m<sup>2</sup>/ 24 hours to 400 cm<sup>3</sup>/ m<sup>2 </sup>/24 hours. There are no trade names for such membranes.
As an oxygen scavenging assembly, any agent capable of absorbing oxygen without its subsequent release may be used. And so, for example, one may mention here
177 705 devices that are sold by ATCA under the names "Oxygen Absorber LH50" or "Oxygen Absorber LH100, LH500" and others.
The oxygen scavenging assembly contained in the package and insulated by the membrane can be an integral part of the package walls, or it can be separated and immersed in the composition.
Generally, the method of making the emulsion of the invention consists of several steps. First, in the first stage, the fat phase (A) and the aqueous phase (B), which form an emulsion, are produced independently of each other. Then, the aqueous phase (B) is introduced into the fat phase (A), this being done under moderate mixing, in a Moritz mixer, at room temperature, under the conditions normally used to prepare any water-in-oil emulsion. The mixture thus formed is an emulsified medium into which retinol is then introduced.
All components of the emulsion according to the invention are degassed under a nitrogen tent at room temperature in a room lit by a sodium lamp to remove any traces of oxygen and replace it with nitrogen. Such degassing lasts at least two hours. Once all traces of oxygen have been removed (which can be checked using an oximeter), retinol and its solvent are weighed and mixed together using a magnetic stirrer until the retinol is completely dissolved. As a result, phase (C) is formed. This phase (C) is then incorporated into the emulsion with paddle mixing to ensure good homogeneity. After homogenization is complete, the emulsion thus obtained is introduced, still under an inert nitrogen atmosphere and under sodium lamp illumination, into the packaging as described above.
The composition of the various emulsions of the invention is illustrated by the following examples, which are not intended to limit the scope of the invention in any way.
Example I. A cream for use around the eyes.
<td>AND</td><td>Abil EM-90 (cetyl dimethicone copolyol) Cyclomethicone D5 (volatile silicone oil) Simagel Si 345 (Hectorite) Miglyol 812 (capric / caprylic acid triglycerides) Gum Q2 1401 (dimethiconal and volatile silicone oil)</td><td> 2% 7% 5% 7,5% 4%</td>
<td>B.</td><td>Glycerine</td><td> 5%</td>
<td></td><td>triethanolamine</td><td> 0,2%</td>
<td></td><td>Deionized water</td><td> 61,3%</td>
<td>C.</td><td>Isofol 16 (hexyl-2 decanol)</td><td> 7,5%</td>
<td></td><td>Retino</td><td> 0,5%</td>
This cream, applied around the eyes two to five times a week, exerts a smoothing effect against fine lines and so-called "crow's feet" around the eyes.
Example II Anti wrinkle cream
<td>AND.</td><td>Abil EM-90 Cyclomethicone D5 Simagel Si 345 Miglyol 812 Gum Q2 1401</td><td> 3% 7% 5% 11,5% 3%</td>
<td>B.</td><td>Glycerine</td><td> 5%</td>
<td></td><td>triethanolamine</td><td> 0,2%</td>
<td></td><td>NaCl</td><td> 0,7%</td>
<td></td><td>Deionized water qs</td><td> 100%</td>
<td>B.</td><td>Isofol 16</td><td> 3%</td>
<td></td><td>retinol</td><td> 0,18%</td>
<td colspan="3">This very mild and nourishing cream is perfect for everyday application</td>
face in the evening for a long-lasting effect in the form of smoothing out wrinkles.
177 705
Example III. Anti-aging lotion.
A. Abil EM-90 1%
Isolan Gi 34 (polyglyceryl-4 isostearate) 5%
Paraffin oil 133%
Cyclomethicone D5 10%
Gum Q2-1401 4%
B. Glycerin 5%
0.2% triethanolamine
NaCl 0.6%
Deionized water qs 100%
C. Diisopropyl adipate 1%
Retinol 0.012%
This gentle body lotion is perfect for body care directed against the effects of aging, but it should be used daily on the whole body. After using it, the skin becomes soft and smooth.
Example IV A care product for lip repair
<td>AND.</td><td>Abil EM-90</td><td> 3%</td>
<td></td><td>Simagel Si 345</td><td> 5%</td>
<td></td><td>Cyclomethicone D5</td><td> 7%</td>
<td></td><td>Gum Q2-1401</td><td> 3%</td>
<td>B.</td><td>AMP (aminomethylpropanol)</td><td> 0,12%</td>
<td></td><td>NaCl</td><td> 0,7%</td>
<td></td><td>Glycerine</td><td> 5 %</td>
<td></td><td>Deionized water qs</td><td> 100%</td>
<td>C.</td><td>Miglyol 812</td><td> 11%</td>
<td></td><td>retinol</td><td> 0,9%</td>
This concentrated cream, very easy to apply when applied, is a nourishing and repairing care product for damaged and wrinkled lips.
Stability test. A stability test was carried out by comparing the emulsions of the invention (Example 1) with various formulations derived from the formulation given in Example 1 (A, B, C, D, E and F).
Composition A. The fat phase of Example 1, to which the following additives were added:
α-tocopherol 0.1% α-tocopherol acetate 1% ascorbyl palmitate 0.2% and the aqueous phase according to example 1, to which:
Desquest 2046 * 0.2% and in which the deionized water pH has been adjusted to an appropriate value. Composition B. Fat phase according to example I, to which was added: ascorbyl palmitate 3- (3,5-di-tert-butyl-4-hydroxy) - 0.2% benzylidene camphor derivative and the aqueous phase as in composition A 0.5% composition C. The fat phase according to example 1 and the aqueous phase according to example 1 but free of triethanolamine.
Composition D. The fat phase of the composition according to example 1 and the aqueous phase according to example 1, and phase C containing retinol dissolved in 0.8 g Polysorbate 20 and 6.9 g cyclohexadimethylsiloxane.
Composition E. The fat phase of Example 1, to which was added:
Pure ethoxyquin (Reluquin from Raschig) and the aqueous phase according to example I. 0.5%
Composition F. A composition according to Example 1 into which the oxygen absorber, isolated into the emulsion, was introduced after its production.
177 705
The stability test performed with these compositions included measuring the percentage of degradation after storage for either one month or two months, or at 4 ° C, or at room temperature or at 45 ° C. The results obtained are shown in the Table below.
Table
<td rowspan="3">Composition</td><td colspan="3">1 month</td><td colspan="3">2 months</td>
<td colspan="6">Temperature</td>
<td>4 ° C</td><td>Room</td><td>45 ° C</td><td>4 ° C</td><td>Room</td><td>45 ° C</td>
<td>Example 1</td><td> 0</td><td> 0</td><td> 19</td><td> 6</td><td> 10</td><td> 33</td>
<td>AND</td><td> 2</td><td> 5</td><td> 25</td><td> 4</td><td> 12</td><td> 35</td>
<td>B</td><td> 0</td><td> 1</td><td> 27</td><td> 2</td><td> 18</td><td> 37</td>
<td>C</td><td> 0</td><td> 8</td><td> 44</td><td> 4</td><td> 34</td><td> 72</td>
<td>D</td><td> 0</td><td> 1</td><td> 40</td><td> 0</td><td> 14</td><td> 68</td>
<td>E</td><td> 0</td><td> 0</td><td> 9</td><td> 0</td><td> 0</td><td> 27</td>
<td>F</td><td> 0</td><td> 1</td><td> 4</td><td> 1</td><td> 16</td><td> 18</td>
The results of this test show that the emulsion according to the invention (example I, F) shows retinol stability comparable to, or even better than, that exhibited by compositions containing one or more antioxidants (A, B) described in the prior art, whereas emulsions made either with retinol dissolved in a solvent other than those selected for use in the process of the invention (D), or with retinol in the presence of an aqueous phase at the wrong pH (C), are less stable. The results in the above table also show that it is possible to stabilize retinol in emulsions not containing antioxidants, and at the same time they show that to increase stability it is advantageous to choose the specific antioxidant in the form of Raluquin (E) introduced into the emulsion according to the invention.
An exemplary package, in accordance with the emulsion of the invention, is described with reference to the attached figure.
The packaging (2) consists of a container (3), the walls (4) of which are made of gas-impermeable material, e.g. thermoformed plastic, or any other suitable material, except that the internal surfaces of said walls contact with emulsion (6) these are non-metallic surfaces and that the material is impervious to visible-ultraviolet radiation.
The container (3) is closed from above by a dispensing assembly working without air intake (8), such as, for example, the dispensing assembly described in patent application FR-A-2666308, consisting of a convex cap outwards (10) and equipped at least one slot (12) located on the top of the hood.
The walls (14,16) of the slit (12) may come together to tightly close the container when at rest. The whole assembly (8) is covered with a hermetic lid (18) ensuring double protection of the emulsion according to the invention, contained in the packaging, against the influence of the external environment.
The oxygen absorber (24) is housed in a pocket (20), independent of the packaging, whose walls (22) are formed of a membrane permeable to gases and impermeable to liquids, such as, for example, the membrane described in patent application FR-A-2671055 . The oxygen absorber (24) enclosed in such a shell is an oxygen scavenging assembly immersed in the emulsion according to the invention which is contained in the said package.
The membrane surrounding the oxygen scavenging assembly can be made of any material that is able to pass oxygen while remaining impermeable 10
177 705 liquid, in particular for the emulsion forming liquids of the present invention. For example, it is made of such a material as polyethylene, polypropylene and poly (terephthalate) polyethylene.
In the resting state, the walls (14, 16) of the hubcap (10) closely adhere to each other, so that the gap (12) is tightly closed. By exerting pressure on the packaging (2), pressure is transferred to the emulsion contained in the packaging, which will cause the walls to propagate (14, 16), thereby allowing the emulsion to escape from the packaging. When the pressure stops, the walls (14, 16) return to their resting position and the gap (12) is tightly closed.
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Priority claims4
| Document | Office | Kind | Date |
|---|---|---|---|
| 9315862 | France | A | |
| 9315862 | France | A | |
| 9315862 | – | – | – |
| FR19930015862 | – | – | – |
Members23
| Document | Office | Kind | |
|---|---|---|---|
| CA2138112A1 | Canada | A1 | |
| FR2714595A1 | France | A1 | |
| PL306580A1 | Poland | A1 | |
| EP0666076A2 | European Patent Office (EPO) | A2 | |
| BR9405480A | Brazil | A | |
| JPH08986A | Japan | A | |
| FR2714595B1 | France | B1 | |
| HUT73060A | Hungary | A | |
| RU94045128A | Russian Federation | A | |
| EP0666076A3 | European Patent Office (EPO) | A3 | |
| US5656672A | United States of America | A | |
| JP2716387B2 | Japan | B2 | |
| US5800596A | United States of America | A | |
| EP0666076B1 | European Patent Office (EPO) | B1 | |
| AT174789T | Austria | T | |
| ATE174789T1 | Austria | T1 | |
| HU215490B | Hungary | B | |
| DE69415491D1 | Germany | D1 | |
| DE69415491T2 | Germany | T2 | |
| ES2128528T3 | Spain | T3 | |
| RU2130302C1 | Russian Federation | C1 | |
| EP0953338A1 | European Patent Office (EPO) | A1 | |
| PL177705B1This record | Poland | B1 |
Numbers
- Publication, DOCDB
- 177705
- Publication, EPODOC
- PL177705B
- Application
- 94306580
- Application, DOCDB
- 30658094
- Application, EPODOC
- PL19940306580
Titles2
- English
- RETINOL CONTAINING WATER-IN-OIL TYPE EMULSION, METHOD OF OBTAINING SAME,ITS APPLICATION AND PACKAGE THEREFOR
- Polish
- Emulsja typu woda w oleju zawierająca retinol i jej opakowanie
Classification
- CPC, 10
- A61K8/671
- A61Q19/00
- A61K8/064
- A61K2800/522
- A61K2800/87
- A61Q19/001
- A61Q19/08
- A61P17/00
- A61P17/16
- A61P43/00
- IPC, 25
- A45D40 00
- A45D34 04
- A61K8 00
- A61K8 06
- A61K8 31
- A61K8 34
- A61K8 41
- A61K8 44
- A61K8 67
- A61K8 89
- A61K8 891
- A61K8 92
- A61K8 97
- A61K9 06
- A61K9 107
- A61K31 047
- A61K31 07
- A61K31 203
- A61P17 00
- A61P17 16
- A61P43 00
- A61Q17 00
- A61Q19 00
- A61Q19 08
- B01J13 00
